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Search of human proteins with 32996731
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32996731 Ras association (RalGDS/AF-6) domain family 5
isoform A [Homo sapiens]
(418 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isofor... 850 0.0
gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isofor... 679 0.0
gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isofor... 448 e-126
gi|20149588 Ras association domain family 1 isoform A [Homo sapi... 275 7e-74
gi|25777684 Ras association domain family 1 isoform D [Homo sapi... 269 4e-72
gi|25777682 Ras association domain family 1 isoform C [Homo sapi... 225 7e-59
gi|25777680 Ras association domain family 1 isoform B [Homo sapi... 211 1e-54
gi|30039698 Ras association (RalGDS/AF-6) domain family member 3... 181 8e-46
gi|25777677 Ras association domain family 2 [Homo sapiens] 73 4e-13
gi|7661964 Ras association domain family 2 [Homo sapiens] 73 4e-13
gi|23510360 Ras association domain family 4 [Homo sapiens] 61 2e-09
gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isofor... 56 5e-08
gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isofor... 56 5e-08
gi|239754138 PREDICTED: hypothetical protein [Homo sapiens] 46 7e-05
gi|239742631 PREDICTED: hypothetical protein XP_002342600 [Homo ... 46 7e-05
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 45 9e-05
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 45 9e-05
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 45 9e-05
gi|239754674 PREDICTED: hypothetical protein [Homo sapiens] 45 2e-04
gi|33286436 gametogenetin [Homo sapiens] 44 4e-04
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 43 6e-04
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 43 6e-04
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 42 8e-04
gi|133908623 protein kinase C, iota [Homo sapiens] 42 8e-04
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 42 8e-04
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 42 8e-04
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 42 8e-04
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 42 8e-04
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 42 0.001
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 42 0.001
>gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isoform A
[Homo sapiens]
Length = 418
Score = 850 bits (2196), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 1 MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR 60
MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR
Sbjct: 1 MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR 60
Query: 61 SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG 120
SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG
Sbjct: 61 SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG 120
Query: 121 EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR 180
EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR
Sbjct: 121 EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR 180
Query: 181 PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI 240
PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI
Sbjct: 181 PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI 240
Query: 241 KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE 300
KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE
Sbjct: 241 KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE 300
Query: 301 VIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLK 360
VIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLK
Sbjct: 301 VIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLK 360
Query: 361 ENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG 418
ENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
Sbjct: 361 ENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG 418
>gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isoform B
[Homo sapiens]
Length = 336
Score = 679 bits (1751), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR 60
MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR
Sbjct: 1 MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR 60
Query: 61 SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG 120
SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG
Sbjct: 61 SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG 120
Query: 121 EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR 180
EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR
Sbjct: 121 EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR 180
Query: 181 PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI 240
PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI
Sbjct: 181 PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI 240
Query: 241 KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE 300
KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE
Sbjct: 241 KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE 300
Query: 301 VIQGLLKKFMVVDNPQKFALFKRIHKDGQV 330
VIQGLLKKFMVVDNPQKFALFKRIHKDGQV
Sbjct: 301 VIQGLLKKFMVVDNPQKFALFKRIHKDGQV 330
>gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isoform C
[Homo sapiens]
Length = 265
Score = 448 bits (1153), Expect = e-126
Identities = 226/227 (99%), Positives = 227/227 (100%)
Query: 192 SQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVT 251
S+NVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVT
Sbjct: 39 SKNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVT 98
Query: 252 VPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMV 311
VPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMV
Sbjct: 99 VPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMV 158
Query: 312 VDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDA 371
VDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDA
Sbjct: 159 VDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDA 218
Query: 372 FSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG 418
FSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
Sbjct: 219 FSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG 265
>gi|20149588 Ras association domain family 1 isoform A [Homo
sapiens]
Length = 340
Score = 275 bits (702), Expect = 7e-74
Identities = 147/297 (49%), Positives = 195/297 (65%), Gaps = 17/297 (5%)
Query: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQ 173
G GH F P GP WCDLCG V+R+ L+C +CKFTCH CR+L+ LDC
Sbjct: 49 GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGP 104
Query: 174 EGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSED 233
L + T NV +PVE + EI+QKI YN + + L M L++D
Sbjct: 105 RDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKD 157
Query: 234 GTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHIS 293
G+YTGFIKV LKL RPV+VP+ +P S+ DA + + +RTSFYLP DA+K LH+
Sbjct: 158 GSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVL 217
Query: 294 STTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTE 353
S T EVI+ LL+KF+VVD+P+KFALF+R + GQV +KL ++PL LRLLAGP +
Sbjct: 218 SRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDK 277
Query: 354 VLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 410
LSFVLKEN++GEV WDAFS+PEL NFL IL++EE++ ++Q+ +KY RQK++EAL
Sbjct: 278 ALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEAL 334
>gi|25777684 Ras association domain family 1 isoform D [Homo
sapiens]
Length = 344
Score = 269 bits (687), Expect = 4e-72
Identities = 147/301 (48%), Positives = 195/301 (64%), Gaps = 21/301 (6%)
Query: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCT----NCKFTCHPECRSLIQLD 169
G GH F P GP WCDLCG V+R+ L+C +CKFTCH CR+L+ LD
Sbjct: 49 GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLD 104
Query: 170 CSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMK 229
C L + T NV +PVE + EI+QKI YN + + L M
Sbjct: 105 CCGPRDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMS 157
Query: 230 LSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQ 289
L++DG+YTGFIKV LKL RPV+VP+ +P S+ DA + + +RTSFYLP DA+K
Sbjct: 158 LNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKH 217
Query: 290 LHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAG 349
LH+ S T EVI+ LL+KF+VVD+P+KFALF+R + GQV +KL ++PL LRLLAG
Sbjct: 218 LHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAG 277
Query: 350 PDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEA 409
P + LSFVLKEN++GEV WDAFS+PEL NFL IL++EE++ ++Q+ +KY RQK++EA
Sbjct: 278 PSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEA 337
Query: 410 L 410
L
Sbjct: 338 L 338
>gi|25777682 Ras association domain family 1 isoform C [Homo
sapiens]
Length = 270
Score = 225 bits (573), Expect = 7e-59
Identities = 114/214 (53%), Positives = 155/214 (72%)
Query: 197 KPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGI 256
+PVE + EI+QKI YN + + L M L++DG+YTGFIKV LKL RPV+VP+
Sbjct: 51 EPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSK 110
Query: 257 RPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQ 316
+P S+ DA + + +RTSFYLP DA+K LH+ S T EVI+ LL+KF+VVD+P+
Sbjct: 111 KPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPR 170
Query: 317 KFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPE 376
KFALF+R + GQV +KL ++PL LRLLAGP + LSFVLKEN++GEV WDAFS+PE
Sbjct: 171 KFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPE 230
Query: 377 LQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 410
L NFL IL++EE++ ++Q+ +KY RQK++EAL
Sbjct: 231 LHNFLRILQREEEEHLRQILQKYSYCRQKIQEAL 264
>gi|25777680 Ras association domain family 1 isoform B [Homo
sapiens]
Length = 189
Score = 211 bits (536), Expect = 1e-54
Identities = 103/183 (56%), Positives = 139/183 (75%)
Query: 228 MKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAI 287
M L++DG+YTGFIKV LKL RPV+VP+ +P S+ DA + + +RTSFYLP DA+
Sbjct: 1 MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV 60
Query: 288 KQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLL 347
K LH+ S T EVI+ LL+KF+VVD+P+KFALF+R + GQV +KL ++PL LRLL
Sbjct: 61 KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL 120
Query: 348 AGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLE 407
AGP + LSFVLKEN++GEV WDAFS+PEL NFL IL++EE++ ++Q+ +KY RQK++
Sbjct: 121 AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ 180
Query: 408 EAL 410
EAL
Sbjct: 181 EAL 183
>gi|30039698 Ras association (RalGDS/AF-6) domain family member 3
[Homo sapiens]
Length = 238
Score = 181 bits (460), Expect = 8e-46
Identities = 102/213 (47%), Positives = 144/213 (67%), Gaps = 22/213 (10%)
Query: 200 EETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQ 259
+ET + +EIK+K+ YN + L M L+ +G YTGFIKV ++L +P PQ
Sbjct: 43 KETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKP--------PQ 94
Query: 260 SIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFA 319
+ ++ K L+ +++ + LHISST TV EVI+ LLKKF+V ++P KFA
Sbjct: 95 TSPNSGK---LSPSSN---------GCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFA 142
Query: 320 LFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQN 379
L+KR H++ QV KLS + PLYLRL+AGP T+ LSFVL+E+E G EW+AFS+PELQN
Sbjct: 143 LYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIG--EWEAFSLPELQN 200
Query: 380 FLTILEKEEQDKIQQVQKKYDKFRQKLEEALRE 412
FL IL+KEE +++Q ++++Y +RQKLEEALRE
Sbjct: 201 FLRILDKEEDEQLQNLKRRYTAYRQKLEEALRE 233
>gi|25777677 Ras association domain family 2 [Homo sapiens]
Length = 326
Score = 73.2 bits (178), Expect = 4e-13
Identities = 44/148 (29%), Positives = 85/148 (57%), Gaps = 10/148 (6%)
Query: 277 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKL 335
+TS + P ++ + I+ST T +V++ LL KF + ++ ++FAL+ +H G+ QKL
Sbjct: 179 KTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGEK--QKL 235
Query: 336 SIADRPLYLRLLAGPDTEVLS-FVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQ 389
D PL R+L GP ++ F++++++ EV +D F +P L++F+ L++EE
Sbjct: 236 KATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEED 295
Query: 390 DKIQQVQKKYDKFRQKLEEALRESQGKP 417
+++++ +KY R + + L E P
Sbjct: 296 REVKKLMRKYTVLRLMIRQRLEEIAETP 323
>gi|7661964 Ras association domain family 2 [Homo sapiens]
Length = 326
Score = 73.2 bits (178), Expect = 4e-13
Identities = 44/148 (29%), Positives = 85/148 (57%), Gaps = 10/148 (6%)
Query: 277 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKL 335
+TS + P ++ + I+ST T +V++ LL KF + ++ ++FAL+ +H G+ QKL
Sbjct: 179 KTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGEK--QKL 235
Query: 336 SIADRPLYLRLLAGPDTEVLS-FVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQ 389
D PL R+L GP ++ F++++++ EV +D F +P L++F+ L++EE
Sbjct: 236 KATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEED 295
Query: 390 DKIQQVQKKYDKFRQKLEEALRESQGKP 417
+++++ +KY R + + L E P
Sbjct: 296 REVKKLMRKYTVLRLMIRQRLEEIAETP 323
>gi|23510360 Ras association domain family 4 [Homo sapiens]
Length = 321
Score = 60.8 bits (146), Expect = 2e-09
Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 14/143 (9%)
Query: 277 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKL 335
+TS + P ++ + ++ST T +V+ LL KF V D P +FAL+ +H+ G+ KL
Sbjct: 177 KTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALY-IVHESGE--RTKL 233
Query: 336 SIADRPLYLRLLAGPDTEVLSFVLKENETG------EVEWDAFSIPELQNFLTILEKEEQ 389
+ PL R+L GP ++ L E + G ++ F +P L +F+ L++EE+
Sbjct: 234 KDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEE 293
Query: 390 DKIQQVQKKYDKFR----QKLEE 408
+I ++ K+ R Q+LE+
Sbjct: 294 REIIKLTMKFQALRLTMLQRLEQ 316
>gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isoform b
[Homo sapiens]
Length = 369
Score = 56.2 bits (134), Expect = 5e-08
Identities = 39/130 (30%), Positives = 67/130 (51%), Gaps = 9/130 (6%)
Query: 278 TSFYLP-LDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLS 336
TS ++P ++ ++ ++S EVI+ LL+KF + ++PQ FAL Q ++L
Sbjct: 222 TSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ---RRLK 278
Query: 337 IADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQDK 391
D PL RLL GP + L + + E+ D F L++ L L +EE+ +
Sbjct: 279 KTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKRE 338
Query: 392 IQQVQKKYDK 401
IQ++ K++K
Sbjct: 339 IQRIVTKFNK 348
>gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isoform a
[Homo sapiens]
Length = 337
Score = 56.2 bits (134), Expect = 5e-08
Identities = 39/130 (30%), Positives = 67/130 (51%), Gaps = 9/130 (6%)
Query: 278 TSFYLP-LDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLS 336
TS ++P ++ ++ ++S EVI+ LL+KF + ++PQ FAL Q ++L
Sbjct: 190 TSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ---RRLK 246
Query: 337 IADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQDK 391
D PL RLL GP + L + + E+ D F L++ L L +EE+ +
Sbjct: 247 KTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKRE 306
Query: 392 IQQVQKKYDK 401
IQ++ K++K
Sbjct: 307 IQRIVTKFNK 316
>gi|239754138 PREDICTED: hypothetical protein [Homo sapiens]
Length = 274
Score = 45.8 bits (107), Expect = 7e-05
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 15 LLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRS-ARRAARGNLEPP 73
L L +PPR +L G PPPPP ++ + A ++ P R S +R ++RG +
Sbjct: 55 LKLPADPPR---ALPGSPEPPPPPPPAAPHVLGARVAAGPTHRLSASHSRVSSRGPVGTK 111
Query: 74 PRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPG 132
P+ RP + R G + R P +PR R R+I Q P P R L PG
Sbjct: 112 PK--RPGQGRRAGARMR-SAAPASPRARAARAISNQSSPPPPPPSRARSRSL-RLSAPG 166
>gi|239742631 PREDICTED: hypothetical protein XP_002342600 [Homo
sapiens]
Length = 274
Score = 45.8 bits (107), Expect = 7e-05
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 15 LLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRS-ARRAARGNLEPP 73
L L +PPR +L G PPPPP ++ + A ++ P R S +R ++RG +
Sbjct: 55 LKLPADPPR---ALPGSPEPPPPPPPAAPHVLGARVAAGPTHRLSASHSRVSSRGPVGTK 111
Query: 74 PRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPG 132
P+ RP + R G + R P +PR R R+I Q P P R L PG
Sbjct: 112 PK--RPGQGRRAGARMR-SAAPASPRARAARAISNQSSPPPPPPSRARSRSL-RLSAPG 166
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 45.4 bits (106), Expect = 9e-05
Identities = 48/142 (33%), Positives = 73/142 (51%), Gaps = 26/142 (18%)
Query: 286 AIKQLHISSTTTVSEVIQGLLKKF---MVVDNPQKFALFKRIHKDGQVLFQKLSIADRPL 342
A K + +SST T +VI+ L +KF M + + K++L++ +H G+ ++L I ++PL
Sbjct: 56 ATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYE-VHVSGE---RRLDIDEKPL 111
Query: 343 YLRLLAGPDTEVLSFVLKENETGEVEWDAFSI-PE-------LQNFLTILEKEEQDKIQQ 394
++L D FVLK NE + A S PE +QNF L K+E
Sbjct: 112 VVQLNWNKDDREGRFVLK-NENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKE------ 164
Query: 395 VQKKYDKFRQKLEEALRESQGK 416
KK K R+K EALR++ K
Sbjct: 165 --KKEKKKREK--EALRQASDK 182
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 45.4 bits (106), Expect = 9e-05
Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 25/142 (17%)
Query: 286 AIKQLHISSTTTVSEVIQGLLKKF---MVVDNPQKFALFKRIHKDGQVLFQKLSIADRPL 342
A K + +SST T +VI+ L +KF M + + K++L++ +H G+ ++L I ++PL
Sbjct: 56 ATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYE-VHVSGE---RRLDIDEKPL 111
Query: 343 YLRLLAGPDTEVLSFVLK-ENETGEVEWDAFSIPE-------LQNFLTILEKEEQDKIQQ 394
++L D FVLK EN+ + + PE +QNF L K+E
Sbjct: 112 VVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKE------ 165
Query: 395 VQKKYDKFRQKLEEALRESQGK 416
KK K R+K EALR++ K
Sbjct: 166 --KKEKKKREK--EALRQASDK 183
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 45.4 bits (106), Expect = 9e-05
Identities = 48/142 (33%), Positives = 73/142 (51%), Gaps = 26/142 (18%)
Query: 286 AIKQLHISSTTTVSEVIQGLLKKF---MVVDNPQKFALFKRIHKDGQVLFQKLSIADRPL 342
A K + +SST T +VI+ L +KF M + + K++L++ +H G+ ++L I ++PL
Sbjct: 56 ATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYE-VHVSGE---RRLDIDEKPL 111
Query: 343 YLRLLAGPDTEVLSFVLKENETGEVEWDAFSI-PE-------LQNFLTILEKEEQDKIQQ 394
++L D FVLK NE + A S PE +QNF L K+E
Sbjct: 112 VVQLNWNKDDREGRFVLK-NENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKE------ 164
Query: 395 VQKKYDKFRQKLEEALRESQGK 416
KK K R+K EALR++ K
Sbjct: 165 --KKEKKKREK--EALRQASDK 182
>gi|239754674 PREDICTED: hypothetical protein [Homo sapiens]
Length = 480
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/118 (36%), Positives = 49/118 (41%), Gaps = 6/118 (5%)
Query: 7 AIGQRPYPLLLD--PEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARR 64
AI QRP P+ L P PPR S G PP + + P P TAP AR R R
Sbjct: 168 AIFQRP-PVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQPGPTAPPARV-REPGR 225
Query: 65 AARGNLEP--PPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG 120
A + EP RA+RP PG R R A RP E+ PR P G
Sbjct: 226 AEGASREPRLRSRAARPPPAPGPGALSRASRSRAAGRPGPGFHGGEKAAAPRAPGGGG 283
>gi|33286436 gametogenetin [Homo sapiens]
Length = 652
Score = 43.5 bits (101), Expect = 4e-04
Identities = 36/115 (31%), Positives = 44/115 (38%), Gaps = 9/115 (7%)
Query: 21 PPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPA 80
P R +LSGP PPPP P + +APG R A A + P P P
Sbjct: 376 PRRRAAALSGPWGSPPPP--------PEQIHSAPGPRRPAPALLAPPTFIFPAPTNGEPM 427
Query: 81 RPLRPGLQQRLRRRPGAPRPR-DVRSIFEQPQDPRVPAERGEGHCFAELVLPGGP 134
RP PGLQ+ P P P ++ P P G GH + L P
Sbjct: 428 RPGPPGLQELPPLPPPTPPPTLQPPALQPTPLPVAPPLTPGLGHKESALAPTAAP 482
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 42.7 bits (99), Expect = 6e-04
Identities = 38/112 (33%), Positives = 48/112 (42%), Gaps = 17/112 (15%)
Query: 17 LDPEPPRYLQSLSGPEL--PPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNL---E 71
L P+ P L L P+L PPPPP P APG +A AA +
Sbjct: 32 LSPQQPPLLLPLLQPQLLQPPPPPP-------PLLFLAAPGTAAAAAAAAAASSSCFSPG 84
Query: 72 PPPRASRPAR-PLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEG 122
PP R AR R G +Q+ RR P A + + R +F PQ P + G G
Sbjct: 85 PPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQ----PQQDGGG 132
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 42.7 bits (99), Expect = 6e-04
Identities = 38/112 (33%), Positives = 48/112 (42%), Gaps = 17/112 (15%)
Query: 17 LDPEPPRYLQSLSGPEL--PPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNL---E 71
L P+ P L L P+L PPPPP P APG +A AA +
Sbjct: 32 LSPQQPPLLLPLLQPQLLQPPPPPP-------PLLFLAAPGTAAAAAAAAAASSSCFSPG 84
Query: 72 PPPRASRPAR-PLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEG 122
PP R AR R G +Q+ RR P A + + R +F PQ P + G G
Sbjct: 85 PPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQ----PQQDGGG 132
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 42.4 bits (98), Expect = 8e-04
Identities = 24/80 (30%), Positives = 32/80 (40%), Gaps = 4/80 (5%)
Query: 94 RPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREV---LRQALR 150
+PG P P + +SI+ + R GH F +C C + RQ R
Sbjct: 102 QPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRF-NRRAYCGQCSERIWGLARQGYR 160
Query: 151 CTNCKFTCHPECRSLIQLDC 170
C NCK H C L+ L C
Sbjct: 161 CINCKLLVHKRCHGLVPLTC 180
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 42.4 bits (98), Expect = 8e-04
Identities = 40/167 (23%), Positives = 72/167 (43%), Gaps = 19/167 (11%)
Query: 94 RPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVL---RQALR 150
RPG P P + +SI+ + GH F C +C + RQ +
Sbjct: 112 RPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRF-NRRAHCAICTDRIWGLGRQGYK 170
Query: 151 CTNCKFTCHPECRSLIQLDCSQQEGLSRD--RPSPESTLTVTFSQNVCKPVEETQRPPTL 208
C NCK H +C L+ ++C + L ++ P +S++ +Q V P + +L
Sbjct: 171 CINCKLLVHKKCHKLVTIECG-RHSLPQEPVMPMDQSSMHSDHAQTVI-PYNPSSH-ESL 227
Query: 209 QEIKQKIDSYNTRE----KNCLG------MKLSEDGTYTGFIKVHLK 245
++ ++ ++ NTRE + LG +++ G+Y + V LK
Sbjct: 228 DQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLK 274
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 42.4 bits (98), Expect = 8e-04
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 134 PGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPEST 186
P C C + + RQ L+C +CKF CH C + + DC + ++ D P E+T
Sbjct: 118 PTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAT 173
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 42.4 bits (98), Expect = 8e-04
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 134 PGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPEST 186
P C C + + RQ L+C +CKF CH C + + DC + ++ D P E+T
Sbjct: 275 PTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAT 330
Score = 34.3 bits (77), Expect = 0.22
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 5/79 (6%)
Query: 134 PGWCDLCGREV---LRQALRCTNCKFTCHPECRSLIQLDCS--QQEGLSRDRPSPESTLT 188
P +CD CG + +RQ L+C C H C I +CS ++ LS + ++
Sbjct: 149 PAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVR 208
Query: 189 VTFSQNVCKPVEETQRPPT 207
+ S+++ EE R T
Sbjct: 209 LGTSESLPCTAEELSRSTT 227
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 42.4 bits (98), Expect = 8e-04
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 134 PGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPEST 186
P C C + + RQ L+C +CKF CH C + + DC + ++ D P E+T
Sbjct: 275 PTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAT 330
Score = 34.3 bits (77), Expect = 0.22
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 5/79 (6%)
Query: 134 PGWCDLCGREV---LRQALRCTNCKFTCHPECRSLIQLDCS--QQEGLSRDRPSPESTLT 188
P +CD CG + +RQ L+C C H C I +CS ++ LS + ++
Sbjct: 149 PAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVR 208
Query: 189 VTFSQNVCKPVEETQRPPT 207
+ S+++ EE R T
Sbjct: 209 LGTSESLPCTAEELSRSTT 227
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 42.4 bits (98), Expect = 8e-04
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 134 PGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPEST 186
P C C + + RQ L+C +CKF CH C + + DC + ++ D P E+T
Sbjct: 275 PTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAT 330
Score = 34.3 bits (77), Expect = 0.22
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 5/79 (6%)
Query: 134 PGWCDLCGREV---LRQALRCTNCKFTCHPECRSLIQLDCS--QQEGLSRDRPSPESTLT 188
P +CD CG + +RQ L+C C H C I +CS ++ LS + ++
Sbjct: 149 PAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVR 208
Query: 189 VTFSQNVCKPVEETQRPPT 207
+ S+++ EE R T
Sbjct: 209 LGTSESLPCTAEELSRSTT 227
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 42.0 bits (97), Expect = 0.001
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 123 HCFAELVLPGGPGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRD 179
H F E+ P +CD C V +Q RC C CH CR ++++C ++ G D
Sbjct: 541 HTFHEVTFRK-PTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGD 599
Query: 180 RPSPESTLTVT 190
P + + T
Sbjct: 600 AGPPGAPVPST 610
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 42.0 bits (97), Expect = 0.001
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 123 HCFAELVLPGGPGWCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRD 179
H F E+ P +CD C V +Q RC C CH CR ++++C ++ G D
Sbjct: 444 HTFHEVTFRK-PTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGD 502
Query: 180 RPSPESTLTVT 190
P + + T
Sbjct: 503 AGPPGAPVPST 513
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,233,535
Number of Sequences: 37866
Number of extensions: 1234441
Number of successful extensions: 10143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 150
Number of HSP's successfully gapped in prelim test: 670
Number of HSP's that attempted gapping in prelim test: 8176
Number of HSP's gapped (non-prelim): 2235
length of query: 418
length of database: 18,247,518
effective HSP length: 105
effective length of query: 313
effective length of database: 14,271,588
effective search space: 4467007044
effective search space used: 4467007044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.