Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 32441283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32441283 Ral GEF with PH domain and SH3 binding motif 2
[Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 1165 0.0
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 690 0.0
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 131 1e-30
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 131 1e-30
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 131 1e-30
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 129 7e-30
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 113 6e-25
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 112 7e-25
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 111 2e-24
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 107 3e-23
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 103 4e-22
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 103 4e-22
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 102 1e-21
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 100 3e-21
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 100 3e-21
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 94 3e-19
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 91 3e-18
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 91 4e-18
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 90 5e-18
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 90 5e-18
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 89 9e-18
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 87 6e-17
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 87 6e-17
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 86 9e-17
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 84 4e-16
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 84 5e-16
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 84 5e-16
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 84 5e-16
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 80 4e-15
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 80 7e-15
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 1165 bits (3015), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MDLMNGQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLM 60
MDLMNGQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLM
Sbjct: 1 MDLMNGQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLM 60
Query: 61 DVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEV 120
DVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEV
Sbjct: 61 DVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEV 120
Query: 121 LSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKE 180
LSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKE
Sbjct: 121 LSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKE 180
Query: 181 DNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIIS 240
DNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIIS
Sbjct: 181 DNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIIS 240
Query: 241 DLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDL 300
DLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDL
Sbjct: 241 DLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDL 300
Query: 301 VGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSA 360
VGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSA
Sbjct: 301 VGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSA 360
Query: 361 TFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLY 420
TFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLY
Sbjct: 361 TFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLY 420
Query: 421 HSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVAS 480
HSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVAS
Sbjct: 421 HSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVAS 480
Query: 481 WTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTD 540
WTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTD
Sbjct: 481 WTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTD 540
Query: 541 SEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE 583
SEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE
Sbjct: 541 SEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE 583
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 690 bits (1780), Expect = 0.0
Identities = 361/587 (61%), Positives = 437/587 (74%), Gaps = 42/587 (7%)
Query: 5 NGQASSVNIAATASEKSSSSESLSDKGSEL-KKSFDAVVFDVLKVTPEEYAGQITLMDVP 63
NG +SV + + + SSSS+SL + + KS+DAVVFDVLKVTPEE+A QITLMD+P
Sbjct: 5 NGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIP 64
Query: 64 VFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSH 123
VFKAIQP+EL+SCGW+KKEK+S APN VAFTRRFN VSFWVVREIL AQTLKIRAE+LSH
Sbjct: 65 VFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSH 124
Query: 124 YIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNY 183
++K AKKL ELNNLH+LM+VVS LQSAPIFRLTKTWALL+RKDKTTFEKL+Y+MSKEDNY
Sbjct: 125 FVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNY 184
Query: 184 KRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQ 243
KR R+YI SLKM P IPYLGIYL DL YIDSAYP++GSI+ENEQRSN MNNILRII+DLQ
Sbjct: 185 KRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQ 244
Query: 244 QSCEYD-IPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDLVG 302
SC YD + LPHVQKYL SV+YIEELQKFVEDDNYKLSL+IEPG+S+PR +S+EDL G
Sbjct: 245 VSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAG 304
Query: 303 PEVGA-SPQSGRKSVAAEGAL---LPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFK 358
P G+ S + R+ + ++ LP TPP PR HRK HSLG N + +++ E K
Sbjct: 305 PSAGSGSARFSRRPTCPDTSVAGSLP-TPPVPR------HRKSHSLGNNMMCQLSVVESK 357
Query: 359 SATFPNAGPRHLLDDSVMEPHAPSRGQA--ESSTLSSGISIGSSDGSELSEETSWPAFER 416
SATFP+ RHLLDDSV+E +P RG A SS +++G+S+GSS+ SE SEE S
Sbjct: 358 SATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMS------ 411
Query: 417 NRLYHSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKP 476
+ L GP N T++G LRRKTLLKEG+KP
Sbjct: 412 SGLESPTGPCICSLGNS---------------------AAVPTMEGPLRRKTLLKEGRKP 450
Query: 477 TVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLF 536
++SWT+YW L G+ L YY AKSL+ T+RKH+KST K VS++GWMV + DDPEHPD+F
Sbjct: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
Query: 537 LLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE 583
L + +KGN YKFQ G+R +A+LW KHL AC+SN+ QVP NLM+FE
Sbjct: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 131 bits (330), Expect = 1e-30
Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A Q+TL+D VFK I +E GW K EK P + T+ FN +S + EI+
Sbjct: 1025 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1084
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ + R + ++ A L+N +A++ + S + + IFRL KTW +S++ K +
Sbjct: 1085 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1144
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
KL+ ++S E +K LR+ + + PC+PYLG+YL+DL +I+ P+ T L N +
Sbjct: 1145 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1203
Query: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290
++++I+R I QQ+ Y I V +YL ++ + E+ Y+ SL+IEP T
Sbjct: 1204 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 1257
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 131 bits (330), Expect = 1e-30
Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A Q+TL+D VFK I +E GW K EK P + T+ FN +S + EI+
Sbjct: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ + R + ++ A L+N +A++ + S + + IFRL KTW +S++ K +
Sbjct: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
KL+ ++S E +K LR+ + + PC+PYLG+YL+DL +I+ P+ T L N +
Sbjct: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
Query: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290
++++I+R I QQ+ Y I V +YL ++ + E+ Y+ SL+IEP T
Sbjct: 1220 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 1273
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 131 bits (330), Expect = 1e-30
Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A Q+TL+D VFK I +E GW K EK P + T+ FN +S + EI+
Sbjct: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ + R + ++ A L+N +A++ + S + + IFRL KTW +S++ K +
Sbjct: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
KL+ ++S E +K LR+ + + PC+PYLG+YL+DL +I+ P+ T L N +
Sbjct: 377 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 435
Query: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290
++++I+R I QQ+ Y I V +YL ++ + E+ Y+ SL+IEP T
Sbjct: 436 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 489
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 129 bits (324), Expect = 7e-30
Identities = 79/236 (33%), Positives = 129/236 (54%), Gaps = 8/236 (3%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A QITL+D +F++I +E GW K +K P + ++ FN +S V +I++
Sbjct: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ RA + ++ A L+N + ++ + S L + I+RL KTWA +S++ K +
Sbjct: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
KL+ +S E +K LR+ + + P +PYLG+YL+DL +I+ P+ T L N +
Sbjct: 1125 KLQKTVSSEGRFKNLRETLKNCN-PPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMR 1183
Query: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
++++I+R I QQ+ Y I P V +YL I + ED Y+LSLKIEP
Sbjct: 1184 MISHIIREIRQFQQT-SYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEP 1233
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 113 bits (282), Expect = 6e-25
Identities = 69/254 (27%), Positives = 130/254 (51%), Gaps = 9/254 (3%)
Query: 43 FDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSF 102
FD+L + P E A Q+TL++ +++A+QP EL W K++K ++PN + R +++
Sbjct: 774 FDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833
Query: 103 WVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALL 162
W + I+ + L+ R V+S I+ + ELNN + ++ VVS + S+P++RL T+ +
Sbjct: 834 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 893
Query: 163 SRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPST--- 219
+ K E+ + ED+YK+ + S+ PC+P+ GIYL+++ + P
Sbjct: 894 PSRQKKILEEAHEL--SEDHYKKYLAKLRSIN-PPCVPFFGIYLTNILKTEEGNPEVLKR 950
Query: 220 -GSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI-EELQKFVEDDN 277
G L N + + I I Q Y + + ++++ ++ + ++K D
Sbjct: 951 HGKELINFSKRRKVAEITGEIQQYQNQ-PYCLRVESDIKRFFENLNPMGNSMEKEFTDYL 1009
Query: 278 YKLSLKIEPGTSTP 291
+ SL+IEP P
Sbjct: 1010 FNKSLEIEPRNPKP 1023
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 112 bits (281), Expect = 7e-25
Identities = 93/321 (28%), Positives = 158/321 (49%), Gaps = 37/321 (11%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHVS 101
+L + +E A Q+TL+D+ +F ++ E W+++++ +A P A +FN V+
Sbjct: 243 LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVT 302
Query: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159
V+ +L A L RA+ L +I+ A++ EL N +L A++S LQS PI+RL ++W
Sbjct: 303 GCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSW 362
Query: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI----------------SSLKMTP---CIP 200
+SR+ +TF KL + S E+N+ R+ + SL P +P
Sbjct: 363 GAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVP 422
Query: 201 YLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCE-YDIPMLPHVQ 257
YLG +L+DL +D+A P G ++ E+R IL I LQ+ C+ Y + P +
Sbjct: 423 YLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEW-EILARIQQLQRRCQSYTLSPHPPIL 481
Query: 258 KYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRSAASREDLVGPEVGASPQSGRKSV 316
L++ + E+ +Y+LS IE P S P S R + + ++ + KS
Sbjct: 482 AALHA------QNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSS 535
Query: 317 AAEGALLPQTPPSPRNLIPHG 337
+ G+ P P SP + + G
Sbjct: 536 SPSGS--PGDPSSPTSSVSPG 554
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 111 bits (277), Expect = 2e-24
Identities = 92/314 (29%), Positives = 155/314 (49%), Gaps = 37/314 (11%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHVS 101
+L + +E A Q+TL+D+ +F ++ E W+++++ +A P A +FN V+
Sbjct: 243 LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVT 302
Query: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159
V+ +L A L RA+ L +I+ A++ EL N +L A++S LQS PI+RL ++W
Sbjct: 303 GCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSW 362
Query: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI----------------SSLKMTP---CIP 200
+SR+ +TF KL + S E+N+ R+ + SL P +P
Sbjct: 363 GAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVP 422
Query: 201 YLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCE-YDIPMLPHVQ 257
YLG +L+DL +D+A P G ++ E+R IL I LQ+ C+ Y + P +
Sbjct: 423 YLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEW-EILARIQQLQRRCQSYTLSPHPPIL 481
Query: 258 KYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRSAASREDLVGPEVGASPQSGRKSV 316
L++ + E+ +Y+LS IE P S P S R + + ++ + KS
Sbjct: 482 AALHA------QNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSS 535
Query: 317 AAEGALLPQTPPSP 330
+ G+ P P SP
Sbjct: 536 SPSGS--PGDPSSP 547
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 107 bits (267), Expect = 3e-23
Identities = 106/374 (28%), Positives = 162/374 (43%), Gaps = 84/374 (22%)
Query: 54 AGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS---APNAVAFTRRFNHVSFWVVREILH 110
A Q+T MD +FK + P C W++++K + AP A +FN ++ VV IL
Sbjct: 272 AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILG 331
Query: 111 AQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKT 168
+ LK RA+++ +I A + L N +L A+VS LQS I+RL KTWA + R
Sbjct: 332 GKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRML 391
Query: 169 TFEKLEYVMSKEDNYKRLRDYI------------SSLK------------------MTPC 198
FE+L + S +N+ R+ + SS+K M
Sbjct: 392 MFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGT 451
Query: 199 IPYLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHV 256
+PYLG +L+DLT +D+A G ++ E+R I +I L QS M P
Sbjct: 452 VPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQI--KLLQSACNSYCMTPD- 508
Query: 257 QKYLNSVQYIEELQKFVEDDNYKLSLKIE----PGTSTPRSAASR----------EDLV- 301
QK+ +Q+ + Q E+++Y LS +IE T++P+ S D++
Sbjct: 509 QKF---IQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRKSMVKRLSLLFLGSDMIT 565
Query: 302 -------GPEVGASPQSGRK-------------SVAAEGALLP-QTPPSPRNLIPHGHRK 340
P+ AS SG S A EG++ P TP P+ +
Sbjct: 566 SPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSS 625
Query: 341 CHSLGYNFIHKMNT 354
C S IH M+T
Sbjct: 626 CSS-----IHSMDT 634
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 103 bits (257), Expect = 4e-22
Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 18/249 (7%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A Q+TL+D +F I+ E+ W K++ +PN FT FN++S+WV I+
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ + R +L +IK K L +LNN ++ +A++S L SAPI RL W K T E
Sbjct: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTSE 970
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMT--PCIPYLGIYLSDLTYIDSAYPSTGSILENEQRS 229
L + D+ R Y ++L PCIPYLG+ L DLT++ P N +
Sbjct: 971 GLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKR 1030
Query: 230 NLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTS 289
NIL + QQ+ YD+ + + N E+ ++LSLKI+P
Sbjct: 1031 WQQFNILDSMRCFQQA-HYDMRRNDDIINFFNDFS-----DHLAEEALWELSLKIKPRNI 1084
Query: 290 TPRSAASRE 298
T R E
Sbjct: 1085 TRRKTDREE 1093
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 103 bits (257), Expect = 4e-22
Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 18/249 (7%)
Query: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
E A Q+TL+D +F I+ E+ W K++ +PN FT FN++S+WV I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
+ + R +L +IK K L +LNN ++ +A++S L SAPI RL W K T E
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTSE 952
Query: 172 KLEYVMSKEDNYKRLRDYISSLKMT--PCIPYLGIYLSDLTYIDSAYPSTGSILENEQRS 229
L + D+ R Y ++L PCIPYLG+ L DLT++ P N +
Sbjct: 953 GLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKR 1012
Query: 230 NLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTS 289
NIL + QQ+ YD+ + + N E+ ++LSLKI+P
Sbjct: 1013 WQQFNILDSMRCFQQA-HYDMRRNDDIINFFNDFS-----DHLAEEALWELSLKIKPRNI 1066
Query: 290 TPRSAASRE 298
T R E
Sbjct: 1067 TRRKTDREE 1075
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 102 bits (253), Expect = 1e-21
Identities = 76/296 (25%), Positives = 139/296 (46%), Gaps = 13/296 (4%)
Query: 43 FDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSF 102
FD++ + P E A Q+TL++ +++ +QP EL W K++K ++PN + R +++
Sbjct: 772 FDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 831
Query: 103 WVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW-AL 161
W + I+ A+ + R VLS I+ + +LNN + ++ +VS + S ++RL T+ AL
Sbjct: 832 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEAL 891
Query: 162 LSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSA----YP 217
RK K E +E +D++K+ + S+ PC+P+ GIYL+++ +
Sbjct: 892 QERKRKILDEAVEL---SQDHFKKYLVKLKSIN-PPCVPFFGIYLTNILKTEEGNNDFLK 947
Query: 218 STGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI-EELQKFVEDD 276
G L N + + I I Q Y + + P ++++ ++ + +K D
Sbjct: 948 KKGKDLINFSKRRKVAEITGEIQQYQNQ-PYCLRIEPDMRRFFENLNPMGSASEKEFTDY 1006
Query: 277 NYKLSLKIEP-GTSTPRSAASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPR 331
+ SL+IEP P + G P +GR + G L P R
Sbjct: 1007 LFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHG-STSGTLRGHPTPLER 1061
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 100 bits (250), Expect = 3e-21
Identities = 80/272 (29%), Positives = 129/272 (47%), Gaps = 36/272 (13%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS---APNAVAFTRRFNHVS 101
+L P+ A Q TLMD +FK + P W++++K AP A +FN V+
Sbjct: 382 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 441
Query: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159
V+ L ++ K RA V+ H+I+ A++ L N +L A++S LQS I RL KTW
Sbjct: 442 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 501
Query: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI--------SSLKMTP-------------- 197
+SR F+KL + S E+NY R+ + ++L+M P
Sbjct: 502 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 561
Query: 198 -CIPYLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLP 254
+PYLG +L+DL +D+A G ++ E+R I +I L QS + + P
Sbjct: 562 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQI--KLLQSACNNYSIAP 619
Query: 255 HVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
Q + +++ E ++Y LS ++EP
Sbjct: 620 DEQ----FGAWFRAVERLSETESYNLSCELEP 647
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 100 bits (250), Expect = 3e-21
Identities = 80/272 (29%), Positives = 129/272 (47%), Gaps = 36/272 (13%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS---APNAVAFTRRFNHVS 101
+L P+ A Q TLMD +FK + P W++++K AP A +FN V+
Sbjct: 327 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 386
Query: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159
V+ L ++ K RA V+ H+I+ A++ L N +L A++S LQS I RL KTW
Sbjct: 387 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 446
Query: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI--------SSLKMTP-------------- 197
+SR F+KL + S E+NY R+ + ++L+M P
Sbjct: 447 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 506
Query: 198 -CIPYLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLP 254
+PYLG +L+DL +D+A G ++ E+R I +I L QS + + P
Sbjct: 507 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQI--KLLQSACNNYSIAP 564
Query: 255 HVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
Q + +++ E ++Y LS ++EP
Sbjct: 565 DEQ----FGAWFRAVERLSETESYNLSCELEP 592
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 94.4 bits (233), Expect = 3e-19
Identities = 79/295 (26%), Positives = 137/295 (46%), Gaps = 34/295 (11%)
Query: 16 TASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSS 75
T E S+ ES +K + D+ P A Q+TLMD +FK + E
Sbjct: 186 TVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLG 245
Query: 76 CGWNK---KEKYSSAPNAVAFTRRFNHVSFWVVREIL--HAQTLKIRAEVLSHYIKTAKK 130
C W + K AP A FN ++ + L H+ + RA V+ H+IK A++
Sbjct: 246 CIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARE 305
Query: 131 LYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKL----------------- 173
LNN ++ +VS L S PI +L KTWA +S K ++L
Sbjct: 306 CLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGS 365
Query: 174 EYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMN 233
V ++E N +R++ + K +P+LG +L++L +DSA P + + +N +
Sbjct: 366 FKVATQERNPQRVQMRLRRQK-KGVVPFLGDFLTELQRLDSAIPD-----DLDGNTNKRS 419
Query: 234 NILRIISDLQ--QSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
+R++ ++Q Q + + P ++K+ V Y +++ + ++YKLS ++EP
Sbjct: 420 KEVRVLQEMQLLQVAAMNYRLRP-LEKF---VTYFTRMEQLSDKESYKLSCQLEP 470
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 90.9 bits (224), Expect = 3e-18
Identities = 99/411 (24%), Positives = 173/411 (42%), Gaps = 67/411 (16%)
Query: 44 DVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHV 100
DVL + A Q+TL+D +F + P + W +++ + P+ A +FN V
Sbjct: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
Query: 101 SFWVVREILHAQTL--------------KIRAEVLSHYIKTAKKLYELNNLHALMAVVSG 146
+ VV +L A + RA +L +I+ A++ L N ++ AVVS
Sbjct: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
Query: 147 LQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI---------------- 190
LQS+PI RL W +R F L + S+EDNY + R+ +
Sbjct: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
Query: 191 ---SSLKMTPCIPYLGIYLSDLTYIDSAYP---STGSILENEQRSNLMNNILRIISDLQQ 244
S + +PYLG +L DL +D+A G I +++R +L + LQ
Sbjct: 418 APRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFA--VLSELRRLQN 475
Query: 245 SCE-YDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRS--------- 293
C Y++ +Q++L ++ + E Q ++++S ++E PG+S P +
Sbjct: 476 ECRGYNLQPDHDIQRWLQGLRPLTEAQ------SHRVSCEVEPPGSSDPPAPRVLRPTLV 529
Query: 294 AASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMN 353
+ +++G +P + G P TP P R + + + ++
Sbjct: 530 ISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTP------APLLTRLAQHMKWPSVSSLD 583
Query: 354 TA-EFKSATFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGS 403
+A E + A P HL + PSRG S++ S +S G+ + S
Sbjct: 584 SALESSPSLHSPADPSHLSPPA--SSPRPSRGHRRSASCGSPLSGGAEEAS 632
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 90.5 bits (223), Expect = 4e-18
Identities = 79/344 (22%), Positives = 148/344 (43%), Gaps = 54/344 (15%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
+L+++ E A Q+++ + +F+ I+P E + + K S A N F N +FWV
Sbjct: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
Query: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSR 164
EIL R +++ H+IK A E N +++ A++SGL AP+ RL TW L
Sbjct: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
Query: 165 KDKTTFEKLEYVMSKEDNYKRLRDYISSLKM-TPCIPYLGIYLSDLTYIDSAYPSTGSIL 223
K + F+ L+ + N + R+ ++S + P IP + DLT++ S L
Sbjct: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGL 891
Query: 224 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQK------------------------- 258
N ++ ++ +R + + S D ++ +K
Sbjct: 892 VNFEKLRMIAKEIRHVGRM-ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTG 950
Query: 259 ----------YLNS-------------VQYIEELQKFVEDDNYK-LSLKIEPGTST-PRS 293
+LN+ QY+ L+ +++++ + LSL+ EP T+T P++
Sbjct: 951 GHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKN 1010
Query: 294 AASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHG 337
++ + +P++G + A+ PQ P P + I G
Sbjct: 1011 PGDKKPVKSETSPVAPRAGSQQ-KAQSLPQPQQQPPPAHKINQG 1053
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 90.1 bits (222), Expect = 5e-18
Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 1/192 (0%)
Query: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVRE 107
++ ++ A Q+T+ D +F + EL + + + N F RRFN + FWVV E
Sbjct: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
Query: 108 ILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDK 167
I L R ++L +IK A E NL++ A+V GL + + RL TW L K K
Sbjct: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
Query: 168 TTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQ 227
+ + E +M N++ R ++ L+ P IP++ + + D+T+ + L N +
Sbjct: 747 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 805
Query: 228 RSNLMNNILRII 239
+ ++ N R +
Sbjct: 806 KMRMIANTARTV 817
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 90.1 bits (222), Expect = 5e-18
Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 1/192 (0%)
Query: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVRE 107
++ ++ A Q+T+ D +F + EL + + + N F RRFN + FWVV E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 108 ILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDK 167
I L R ++L +IK A E NL++ A+V GL + + RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 168 TTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQ 227
+ + E +M N++ R ++ L+ P IP++ + + D+T+ + L N +
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 949
Query: 228 RSNLMNNILRII 239
+ ++ N R +
Sbjct: 950 KMRMIANTARTV 961
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 89.4 bits (220), Expect = 9e-18
Identities = 63/244 (25%), Positives = 116/244 (47%), Gaps = 8/244 (3%)
Query: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
+L + + A ++ D +F +I EL ++++ N +R N V WV
Sbjct: 491 ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550
Query: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSR 164
EIL L R +++ +IK A NL++ A+V GL +A + RL++TW +
Sbjct: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
Query: 165 KDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILE 224
K K F +LE + N+K RD +K P IP++ + L D+T+I + L
Sbjct: 611 KFKKLFSELESLTDPSLNHKAYRDAFKKMK-PPKIPFMPLLLKDVTFIHEGNKTFLDNLV 669
Query: 225 NEQRSNLMNNILRIISDLQQSCEYDIPMLPH--VQKYLNSVQYIEELQKFVEDDNYKLSL 282
N ++ +++ + +R + + + D+ H ++ Y+N + I+ Q ++LS
Sbjct: 670 NFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSH 724
Query: 283 KIEP 286
+IEP
Sbjct: 725 RIEP 728
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 86.7 bits (213), Expect = 6e-17
Identities = 94/338 (27%), Positives = 147/338 (43%), Gaps = 33/338 (9%)
Query: 35 KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQ-PDELSSCGWNKKEKYSSAPNAVAF 93
KK ++FD L+ P E A +T ++ F+ I D S E + ++A
Sbjct: 140 KKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIAL 197
Query: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
FN +S WV +L T + RAEV++ +I AKKL +L N + LMAVV GL + I
Sbjct: 198 ---FNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
RL +T + LS + + ++ ++S NY R + IP LG++L DL +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFK-IPILGVHLKDLIAVH 313
Query: 214 SAYPS-TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKF 272
+P T N + + ++ L + LQ + + P + + S+
Sbjct: 314 VIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----- 368
Query: 273 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA-AEGALLPQTPPSPR 331
EDD YKLSL +EP S + SP + K V E AL P P
Sbjct: 369 TEDDIYKLSLVLEPRNSKSQP-------------TSPTTPNKPVVPLEWALGVMPKPDPT 415
Query: 332 NLIPHGHRKCHSLGYNFIHK----MNTAEFKS--ATFP 363
+ H + S+ N+ H ++ +F+S A FP
Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFP 453
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 86.7 bits (213), Expect = 6e-17
Identities = 94/338 (27%), Positives = 147/338 (43%), Gaps = 33/338 (9%)
Query: 35 KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQ-PDELSSCGWNKKEKYSSAPNAVAF 93
KK ++FD L+ P E A +T ++ F+ I D S E + ++A
Sbjct: 140 KKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIAL 197
Query: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
FN +S WV +L T + RAEV++ +I AKKL +L N + LMAVV GL + I
Sbjct: 198 ---FNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
RL +T + LS + + ++ ++S NY R + IP LG++L DL +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFK-IPILGVHLKDLIAVH 313
Query: 214 SAYPS-TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKF 272
+P T N + + ++ L + LQ + + P + + S+
Sbjct: 314 VIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----- 368
Query: 273 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA-AEGALLPQTPPSPR 331
EDD YKLSL +EP S + SP + K V E AL P P
Sbjct: 369 TEDDIYKLSLVLEPRNSKSQP-------------TSPTTPNKPVVPLEWALGVMPKPDPT 415
Query: 332 NLIPHGHRKCHSLGYNFIHK----MNTAEFKS--ATFP 363
+ H + S+ N+ H ++ +F+S A FP
Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFP 453
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 85.9 bits (211), Expect = 9e-17
Identities = 94/338 (27%), Positives = 147/338 (43%), Gaps = 34/338 (10%)
Query: 35 KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQ-PDELSSCGWNKKEKYSSAPNAVAF 93
KK ++FD L+ P E A +T ++ F+ I D S E + ++A
Sbjct: 140 KKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIAL 197
Query: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
FN +S WV +L T + RAEV++ +I AKKL +L N + LMAVV GL + I
Sbjct: 198 ---FNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
RL +T + LS + + ++ ++S NY R + IP LG++L DL +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFK-IPILGVHLKDLIAVH 313
Query: 214 SAYPS-TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKF 272
+P T N + + ++ L + LQ + + P + + S+
Sbjct: 314 VIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----- 368
Query: 273 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA-AEGALLPQTPPSPR 331
EDD YKLSL +EP S + SP + K V E AL P P
Sbjct: 369 TEDDIYKLSLVLEPRNS--------------KSPTSPTTPNKPVVPLEWALGVMPKPDPT 414
Query: 332 NLIPHGHRKCHSLGYNFIHK----MNTAEFKS--ATFP 363
+ H + S+ N+ H ++ +F+S A FP
Sbjct: 415 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFP 452
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 84.0 bits (206), Expect = 4e-16
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 10/246 (4%)
Query: 44 DVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFW 103
++ +V PE+ A +T +F+ + E ++ + N +R + V+ W
Sbjct: 213 EIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHW 272
Query: 104 VVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLS 163
V E+L + RA++L +IK A + +L + AVV GL +A + RL TW L
Sbjct: 273 VATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLP 332
Query: 164 RKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSIL 223
K K F K E + N+K R+ IS +K P IP++ + L DLT++ + L
Sbjct: 333 GKFKNLFRKFENLTDPCRNHKSYREVISKMK-PPVIPFVPLILKDLTFLHEGSKTLVDGL 391
Query: 224 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDN----YK 279
N ++ + + +R I + P+ ++ N +Q +++F DN ++
Sbjct: 392 VNIEKLHSVAEKVRTIRKYRSR-----PLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFE 446
Query: 280 LSLKIE 285
LS K+E
Sbjct: 447 LSYKLE 452
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 83.6 bits (205), Expect = 5e-16
Identities = 56/193 (29%), Positives = 95/193 (49%), Gaps = 2/193 (1%)
Query: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVR 106
V+ ++ AGQ+T D +F +I EL + + + N F RRFN + +WV
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678
Query: 107 EILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKD 166
E+ RA++L +IK A L E NL++ AV+ GL ++ I RL TW L K
Sbjct: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738
Query: 167 KTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENE 226
+ + LE ++ N++ R ++ L P IP++ + L D+T+I + L N
Sbjct: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFIHEGNHTLVENLINF 797
Query: 227 QRSNLMNNILRII 239
++ +M R++
Sbjct: 798 EKMRMMARAARML 810
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 83.6 bits (205), Expect = 5e-16
Identities = 56/193 (29%), Positives = 95/193 (49%), Gaps = 2/193 (1%)
Query: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVR 106
V+ ++ AGQ+T D +F +I EL + + + N F RRFN + +WV
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678
Query: 107 EILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKD 166
E+ RA++L +IK A L E NL++ AV+ GL ++ I RL TW L K
Sbjct: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738
Query: 167 KTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENE 226
+ + LE ++ N++ R ++ L P IP++ + L D+T+I + L N
Sbjct: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFIHEGNHTLVENLINF 797
Query: 227 QRSNLMNNILRII 239
++ +M R++
Sbjct: 798 EKMRMMARAARML 810
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 83.6 bits (205), Expect = 5e-16
Identities = 56/193 (29%), Positives = 95/193 (49%), Gaps = 2/193 (1%)
Query: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVR 106
V+ ++ AGQ+T D +F +I EL + + + N F RRFN + +WV
Sbjct: 661 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 720
Query: 107 EILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKD 166
E+ RA++L +IK A L E NL++ AV+ GL ++ I RL TW L K
Sbjct: 721 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 780
Query: 167 KTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENE 226
+ + LE ++ N++ R ++ L P IP++ + L D+T+I + L N
Sbjct: 781 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFIHEGNHTLVENLINF 839
Query: 227 QRSNLMNNILRII 239
++ +M R++
Sbjct: 840 EKMRMMARAARML 852
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 80.5 bits (197), Expect = 4e-15
Identities = 91/345 (26%), Positives = 154/345 (44%), Gaps = 40/345 (11%)
Query: 30 KGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPN 89
K + KK +++FD L+ PEE + +T ++ F+ I + + N K + P
Sbjct: 188 KSNTSKKRKVSLLFDHLE--PEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKEN--PT 243
Query: 90 AVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQS 149
N +S WV +L T ++RAEV +I+ A+KL++L N + LMAV+ GL
Sbjct: 244 MERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCH 303
Query: 150 APIFRLTKTWALLSRK-DKTTFEKLEYVMSKE--DNYKRLRDYISSLKMTPCIPYLGIYL 206
+ I RL +T + + + +K E E + S DNY+R + K IP LG++L
Sbjct: 304 SSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFK----IPILGVHL 359
Query: 207 SDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI 266
DL + A P + + + + + + IS+L Q E P+ K L + +
Sbjct: 360 KDLISLYEAMPD--YLEDGKVNVHKLLALYNHISELVQLQEVAPPL--EANKDLVHLLTL 415
Query: 267 EELQKFVEDDNYKLSLKIEPGT--STPRSAASREDLVGPEVGASPQSGRKSVAAEGALLP 324
+ ED+ Y+LS EP + P + + +V G SP+
Sbjct: 416 SLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPK-------------- 461
Query: 325 QTPPSPRNLIPHGHRKCHSLGYNFIHK----MNTAEFK--SATFP 363
P P+ + H R S+ N+ H ++ EF+ +A+FP
Sbjct: 462 ---PDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFP 503
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/209 (30%), Positives = 96/209 (45%), Gaps = 12/209 (5%)
Query: 93 FTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPI 152
F FN VS WV IL T RA V++H++ A+KL +L N + LMAVV GL + I
Sbjct: 196 FISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSI 255
Query: 153 FRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCI----PYLGIYLSD 208
RL +T + +S + +E L +++ NY R ++ C+ P LG++L D
Sbjct: 256 SRLKETHSHVSPETIKLWEGLTELVTATGNYGNYR-----RRLAACVGFRFPILGVHLKD 310
Query: 209 LTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEE 268
L + A P M + I+ +L P+ L S+ +
Sbjct: 311 LVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPV--QANPDLLSLLTVSL 368
Query: 269 LQKFVEDDNYKLSLKIEP-GTSTPRSAAS 296
Q ED+ Y+LSL+ EP S+P S S
Sbjct: 369 DQYQTEDELYQLSLQREPRSKSSPTSPTS 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,354,637
Number of Sequences: 37866
Number of extensions: 929763
Number of successful extensions: 3476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3338
Number of HSP's gapped (non-prelim): 119
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.