Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 31982881

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31982881 CAP-GLY domain containing linker protein family,
member 4 [Homo sapiens]
         (705 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31982881 CAP-GLY domain containing linker protein family, mem...  1412   0.0  
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap...   496   e-140
gi|38044112 restin isoform b [Homo sapiens]                           173   6e-43
gi|4506751 restin isoform a [Homo sapiens]                            173   6e-43
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ...   149   1e-35
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2...   149   1e-35
gi|171184451 centrosome-associated protein 350 [Homo sapiens]          94   4e-19
gi|46852172 kinesin family member 13B [Homo sapiens]                   85   2e-16
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        83   8e-16
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       78   3e-14
gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]           77   7e-14
gi|53832024 nuclear factor of kappa light polypeptide gene enhan...    51   4e-06
gi|13899229 nuclear factor of kappa light polypeptide gene enhan...    51   4e-06
gi|118442828 beta-tubulin cofactor E [Homo sapiens]                    50   9e-06
gi|4507375 beta-tubulin cofactor E [Homo sapiens]                      50   9e-06
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    48   4e-05
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  47   5e-05
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...    46   1e-04
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...    46   1e-04
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...    45   2e-04
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    44   4e-04
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        44   4e-04
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         44   4e-04
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         44   4e-04
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    44   4e-04
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso...    44   5e-04
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso...    44   5e-04
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         44   7e-04
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         44   7e-04
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    43   9e-04

>gi|31982881 CAP-GLY domain containing linker protein family, member
           4 [Homo sapiens]
          Length = 705

 Score = 1412 bits (3656), Expect = 0.0
 Identities = 705/705 (100%), Positives = 705/705 (100%)

Query: 1   MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDCEFSFFDPNDASCQEIL 60
           MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDCEFSFFDPNDASCQEIL
Sbjct: 1   MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDCEFSFFDPNDASCQEIL 60

Query: 61  FDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAH 120
           FDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAH
Sbjct: 61  FDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAH 120

Query: 121 GIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDA 180
           GIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDA
Sbjct: 121 GIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDA 180

Query: 181 TCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADA 240
           TCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADA
Sbjct: 181 TCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADA 240

Query: 241 AATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLR 300
           AATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLR
Sbjct: 241 AATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLR 300

Query: 301 FCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNIT 360
           FCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNIT
Sbjct: 301 FCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNIT 360

Query: 361 HTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420
           HTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA
Sbjct: 361 HTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420

Query: 421 LLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSR 480
           LLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSR
Sbjct: 421 LLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSR 480

Query: 481 CEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSP 540
           CEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSP
Sbjct: 481 CEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSP 540

Query: 541 RYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKS 600
           RYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKS
Sbjct: 541 RYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKS 600

Query: 601 KAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRS 660
           KAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRS
Sbjct: 601 KAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRS 660

Query: 661 AKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC 705
           AKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC
Sbjct: 661 AKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC 705


>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
           sapiens]
          Length = 547

 Score =  496 bits (1277), Expect = e-140
 Identities = 242/394 (61%), Positives = 302/394 (76%), Gaps = 8/394 (2%)

Query: 30  PVIFSISAAPMPSDCEFSFFDPNDASCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIG 89
           PV+   + AP+P D  F+FFDPND +CQEILFDP+T++ ELFAI+RQWVPQVQ  ID+IG
Sbjct: 41  PVVHPSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIG 100

Query: 90  NEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWT 149
           NEIL+RGC+VNDRDGLTDMTLLHY CK+GAHG+GD   AV+ + QL+ LGAD++LRSRWT
Sbjct: 101 NEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT 160

Query: 150 NMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209
           NMNALHYAAYFDVP+L+RV+LK ++P+ V++TCSDFN G+ALHIAA +LC GA KCLLE 
Sbjct: 161 NMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEH 220

Query: 210 GANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNY 269
           GANPA RN KGQ+PA+VVPDP+DM L+ A+AA  AKE++ +L +AVPLSC + K  LPNY
Sbjct: 221 GANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNY 280

Query: 270 DHVTGKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVG 329
           D+V G  ML++LGL+LGDRV++ GQK GTLRFCGTTEFASGQW G+ELDEPEGKN+GSVG
Sbjct: 281 DNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVG 340

Query: 330 KVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTG 389
            V+YF C PK G+FA +SKISKA      +   PS+  + P  R+ ++D + VT K    
Sbjct: 341 GVRYFICPPKQGLFASVSKISKA------VDAPPSSVTSTP--RTPRMDFSRVTGKGRRE 392

Query: 390 LMTSKKDSASESTLSLPPGEELKTVTEKDVALLG 423
               KK  +S S  SL   +  K      V + G
Sbjct: 393 HKGKKKTPSSPSLGSLQQRDGAKAEVGDQVLVAG 426



 Score =  159 bits (402), Expect = 8e-39
 Identities = 84/208 (40%), Positives = 120/208 (57%), Gaps = 21/208 (10%)

Query: 485 LRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGI 544
           LRLG+RVL+ GQ+ GT+RF GTT FA G W G+EL++P GKNDGSVGGV+YF C P+ G+
Sbjct: 294 LRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGL 353

Query: 545 FAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAAL 604
           FA  S++ +  D+  +                  S ++T  + + + +R     + +   
Sbjct: 354 FASVSKISKAVDAPPS------------------SVTSTPRTPRMDFSRVTGKGRREHKG 395

Query: 605 RRSWSSTPTAGGIE--GSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAK 662
           ++   S+P+ G ++     K   G QVL+ +  + G VR+ G TDFA G W G+EL    
Sbjct: 396 KKKTPSSPSLGSLQQRDGAKAEVGDQVLV-AGQKQGIVRFYGKTDFAPGYWYGIELDQPT 454

Query: 663 GKNDGSVGDKRYFTCKPNHGVLVRPSRV 690
           GK+DGSV   RYFTC P HGV    SR+
Sbjct: 455 GKHDGSVFGVRYFTCPPRHGVFAPASRI 482



 Score =  121 bits (303), Expect = 3e-27
 Identities = 68/176 (38%), Positives = 100/176 (56%), Gaps = 15/176 (8%)

Query: 424 SVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSRCEG 483
           SV+S   T  ++  +   K +      KKT S SPSL S                 R   
Sbjct: 370 SVTSTPRTPRMDFSRVTGKGRREHKGKKKTPS-SPSLGSL--------------QQRDGA 414

Query: 484 ELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYG 543
           +  +G++VLV GQ+ G +RF+G T+FAPGYWYGIEL++P GK+DGSV GV+YF+C PR+G
Sbjct: 415 KAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHG 474

Query: 544 IFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSK 599
           +FAP SR+QR+  S D+  +    K+ H     +   + T+  + K+I   N+ S+
Sbjct: 475 VFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISR 530



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 50/122 (40%), Positives = 77/122 (63%), Gaps = 10/122 (8%)

Query: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343
           ++GD+V++AGQK G +RF G T+FA G W GIELD+P GK++GSV  V+YF C P++G+F
Sbjct: 417 EVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVF 476

Query: 344 APLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNT-GLMTSKKDSASEST 402
           AP S+I +  G         ST +    + ++K+    +T    T   + + KD ASE++
Sbjct: 477 APASRIQRIGG---------STDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENS 527

Query: 403 LS 404
           +S
Sbjct: 528 IS 529



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 33/69 (47%), Positives = 45/69 (65%), Gaps = 1/69 (1%)

Query: 623 LHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHG 682
           L  G +VLL    + GT+R+ G T+FASG W+G+EL   +GKNDGSVG  RYF C P  G
Sbjct: 294 LRLGDRVLL-DGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQG 352

Query: 683 VLVRPSRVT 691
           +    S+++
Sbjct: 353 LFASVSKIS 361


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  173 bits (438), Expect = 6e-43
 Identities = 117/337 (34%), Positives = 174/337 (51%), Gaps = 63/337 (18%)

Query: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343
           ++G+RV + G K G ++F G T+FA GQWAGI LDEP GKN+GSV  V+YF+C P  GIF
Sbjct: 59  RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118

Query: 344 APLSKISK---AKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
              SK+++   A+     +  TP+++A  PL  S                 T+   S+S 
Sbjct: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTS-----------------TASMVSSSP 161

Query: 401 STLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSL 460
           ST S  P +  +   ++                       P     IS+  KT S+S  +
Sbjct: 162 STPSNIPQKPSQPAAKE-----------------------PSATPPISNLTKTASES--I 196

Query: 461 SSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELE 520
           S+ + AG         +  + E EL++G+RVLV G + G +RF G T+FA G W G+EL+
Sbjct: 197 SNLSEAG---------SIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELD 247

Query: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
           +P GKNDG+V G +YF C P+YG+FAP  +V ++     T ++  +N         RR  
Sbjct: 248 EPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN-------AVRRVM 300

Query: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGI 617
           +TTSAS ++  +  +  S S  A   S SS P+  G+
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVA--SSVSSRPSRTGL 335



 Score =  143 bits (360), Expect = 6e-34
 Identities = 88/241 (36%), Positives = 122/241 (50%), Gaps = 17/241 (7%)

Query: 470 SSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGS 529
           SS  S+        + R+GERV V G + G I+F G T FAPG W GI L++P GKNDGS
Sbjct: 43  SSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS 102

Query: 530 VGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASS-- 587
           V GV+YF C P  GIF  PS++ R   + D  + + +   + +      S ++  +SS  
Sbjct: 103 VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPS 162

Query: 588 -------------QKEINRRNAFSKSKAALRRSWSSTPTAGGI-EGSVKLHEGSQVLLTS 633
                         KE +     S        S S+   AG I +G  +L  G +VL+  
Sbjct: 163 TPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLV-G 221

Query: 634 SNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYR 693
             + G VR++G TDFA G W G+EL    GKNDG+V   RYF C+P +G+     +VT  
Sbjct: 222 GTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI 281

Query: 694 G 694
           G
Sbjct: 282 G 282



 Score =  101 bits (252), Expect = 2e-21
 Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 7/169 (4%)

Query: 254 AVPLSCNISKAMLPNYDHVT--GKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQ 311
           A P   N++K    +  +++  G        LK+GDRV++ G K G +RF G T+FA G+
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 312 WAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPL 371
           W G+ELDEP GKN+G+V   +YF+C PKYG+FAP+ K++K          T   KA    
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI-----GFPSTTPAKAKANA 295

Query: 372 IRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420
           +R      +    +  +    S   S + S  S P    L T T    A
Sbjct: 296 VRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  173 bits (438), Expect = 6e-43
 Identities = 117/337 (34%), Positives = 174/337 (51%), Gaps = 63/337 (18%)

Query: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343
           ++G+RV + G K G ++F G T+FA GQWAGI LDEP GKN+GSV  V+YF+C P  GIF
Sbjct: 59  RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118

Query: 344 APLSKISK---AKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
              SK+++   A+     +  TP+++A  PL  S                 T+   S+S 
Sbjct: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTS-----------------TASMVSSSP 161

Query: 401 STLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSL 460
           ST S  P +  +   ++                       P     IS+  KT S+S  +
Sbjct: 162 STPSNIPQKPSQPAAKE-----------------------PSATPPISNLTKTASES--I 196

Query: 461 SSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELE 520
           S+ + AG         +  + E EL++G+RVLV G + G +RF G T+FA G W G+EL+
Sbjct: 197 SNLSEAG---------SIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELD 247

Query: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
           +P GKNDG+V G +YF C P+YG+FAP  +V ++     T ++  +N         RR  
Sbjct: 248 EPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN-------AVRRVM 300

Query: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGI 617
           +TTSAS ++  +  +  S S  A   S SS P+  G+
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVA--SSVSSRPSRTGL 335



 Score =  143 bits (360), Expect = 6e-34
 Identities = 88/241 (36%), Positives = 122/241 (50%), Gaps = 17/241 (7%)

Query: 470 SSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGS 529
           SS  S+        + R+GERV V G + G I+F G T FAPG W GI L++P GKNDGS
Sbjct: 43  SSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS 102

Query: 530 VGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASS-- 587
           V GV+YF C P  GIF  PS++ R   + D  + + +   + +      S ++  +SS  
Sbjct: 103 VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPS 162

Query: 588 -------------QKEINRRNAFSKSKAALRRSWSSTPTAGGI-EGSVKLHEGSQVLLTS 633
                         KE +     S        S S+   AG I +G  +L  G +VL+  
Sbjct: 163 TPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLV-G 221

Query: 634 SNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYR 693
             + G VR++G TDFA G W G+EL    GKNDG+V   RYF C+P +G+     +VT  
Sbjct: 222 GTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI 281

Query: 694 G 694
           G
Sbjct: 282 G 282



 Score =  101 bits (252), Expect = 2e-21
 Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 7/169 (4%)

Query: 254 AVPLSCNISKAMLPNYDHVT--GKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQ 311
           A P   N++K    +  +++  G        LK+GDRV++ G K G +RF G T+FA G+
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 312 WAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPL 371
           W G+ELDEP GKN+G+V   +YF+C PKYG+FAP+ K++K          T   KA    
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI-----GFPSTTPAKAKANA 295

Query: 372 IRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420
           +R      +    +  +    S   S + S  S P    L T T    A
Sbjct: 296 VRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344


>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
           [Homo sapiens]
          Length = 1046

 Score =  149 bits (375), Expect = 1e-35
 Identities = 105/344 (30%), Positives = 163/344 (47%), Gaps = 68/344 (19%)

Query: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344
           +G+RV + G K G +++ G T+FA GQWAG+ LD+P GKN+G+VG V+YF+C    GIF 
Sbjct: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140

Query: 345 PLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLS 404
             SK+          T  P+ + +                    G      +S +   LS
Sbjct: 141 RPSKL----------TRQPTAEGS--------------------GSDAHSVESLTAQNLS 170

Query: 405 LPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRA 464
           L  G     +T + +                     P +++ ++S+ KT ++S       
Sbjct: 171 LHSGTATPPLTSRVI---------------------PLRESVLNSSVKTGNES------- 202

Query: 465 SAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHG 524
                S+ + + +  R E +LRLG+RVLV G + G +R+ G T+FA G W G+EL++P G
Sbjct: 203 ----GSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLG 258

Query: 525 KNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPG---FRRSFS 581
           KNDG+V G +YF C P++G+FAP  +V R+     + S   + K      G      S S
Sbjct: 259 KNDGAVAGTRYFQCPPKFGLFAPIHKVIRI--GFPSTSPAKAKKTKRMAMGVSALTHSPS 316

Query: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHE 625
           ++S SS   +        S++ L    SS   A  I G+  L E
Sbjct: 317 SSSISSVSSVASSVGGRPSRSGLLTETSSR-YARKISGTTALQE 359



 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/283 (33%), Positives = 134/283 (47%), Gaps = 18/283 (6%)

Query: 406 PPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRAS 465
           PPG   K  +       GS SS ++ ++     S   KQ++  S+    + +P      +
Sbjct: 9   PPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKA 68

Query: 466 AGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK 525
           A +              G+  +GERV V G + G +++ G T FAPG W G+ L+ P GK
Sbjct: 69  AEVGDDFL---------GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGK 119

Query: 526 NDGSVGGVQYFSCSPRYGIFAPPSRVQRVT----DSLDTLSEISSNKQNHSYPGFRRSFS 581
           NDG+VGGV+YF C    GIF  PS++ R         D  S  S   QN S        +
Sbjct: 120 NDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLS---LHSGTA 176

Query: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIE-GSVKLHEGSQVLLTSSNEMGTV 640
           T   +S+    R +  + S      S S+   +G ++ G   L  G +VL+    + G V
Sbjct: 177 TPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLV-GGTKTGVV 235

Query: 641 RYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGV 683
           RYVG TDFA G W G+EL    GKNDG+V   RYF C P  G+
Sbjct: 236 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 44/101 (43%), Positives = 66/101 (65%), Gaps = 16/101 (15%)

Query: 283 LKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGI 342
           L+LGDRV++ G K G +R+ G T+FA G+W G+ELDEP GKN+G+V   +YF+C PK+G+
Sbjct: 219 LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278

Query: 343 FAPLSKI--------SKAKGRRKN--------ITHTPSTKA 367
           FAP+ K+        S AK ++          +TH+PS+ +
Sbjct: 279 FAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSS 319



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 27/54 (50%), Positives = 34/54 (62%)

Query: 638 GTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVT 691
           G V+Y+G T FA G W G+ L    GKNDG+VG  RYF C    G+  RPS++T
Sbjct: 93  GVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLT 146


>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
           [Homo sapiens]
          Length = 1011

 Score =  149 bits (375), Expect = 1e-35
 Identities = 105/344 (30%), Positives = 163/344 (47%), Gaps = 68/344 (19%)

Query: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344
           +G+RV + G K G +++ G T+FA GQWAG+ LD+P GKN+G+VG V+YF+C    GIF 
Sbjct: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140

Query: 345 PLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLS 404
             SK+          T  P+ + +                    G      +S +   LS
Sbjct: 141 RPSKL----------TRQPTAEGS--------------------GSDAHSVESLTAQNLS 170

Query: 405 LPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRA 464
           L  G     +T + +                     P +++ ++S+ KT ++S       
Sbjct: 171 LHSGTATPPLTSRVI---------------------PLRESVLNSSVKTGNES------- 202

Query: 465 SAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHG 524
                S+ + + +  R E +LRLG+RVLV G + G +R+ G T+FA G W G+EL++P G
Sbjct: 203 ----GSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLG 258

Query: 525 KNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPG---FRRSFS 581
           KNDG+V G +YF C P++G+FAP  +V R+     + S   + K      G      S S
Sbjct: 259 KNDGAVAGTRYFQCPPKFGLFAPIHKVIRI--GFPSTSPAKAKKTKRMAMGVSALTHSPS 316

Query: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHE 625
           ++S SS   +        S++ L    SS   A  I G+  L E
Sbjct: 317 SSSISSVSSVASSVGGRPSRSGLLTETSSR-YARKISGTTALQE 359



 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/283 (33%), Positives = 134/283 (47%), Gaps = 18/283 (6%)

Query: 406 PPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRAS 465
           PPG   K  +       GS SS ++ ++     S   KQ++  S+    + +P      +
Sbjct: 9   PPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKA 68

Query: 466 AGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK 525
           A +              G+  +GERV V G + G +++ G T FAPG W G+ L+ P GK
Sbjct: 69  AEVGDDFL---------GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGK 119

Query: 526 NDGSVGGVQYFSCSPRYGIFAPPSRVQRVT----DSLDTLSEISSNKQNHSYPGFRRSFS 581
           NDG+VGGV+YF C    GIF  PS++ R         D  S  S   QN S        +
Sbjct: 120 NDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLS---LHSGTA 176

Query: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIE-GSVKLHEGSQVLLTSSNEMGTV 640
           T   +S+    R +  + S      S S+   +G ++ G   L  G +VL+    + G V
Sbjct: 177 TPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLV-GGTKTGVV 235

Query: 641 RYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGV 683
           RYVG TDFA G W G+EL    GKNDG+V   RYF C P  G+
Sbjct: 236 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 44/101 (43%), Positives = 66/101 (65%), Gaps = 16/101 (15%)

Query: 283 LKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGI 342
           L+LGDRV++ G K G +R+ G T+FA G+W G+ELDEP GKN+G+V   +YF+C PK+G+
Sbjct: 219 LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278

Query: 343 FAPLSKI--------SKAKGRRKN--------ITHTPSTKA 367
           FAP+ K+        S AK ++          +TH+PS+ +
Sbjct: 279 FAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSS 319



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 27/54 (50%), Positives = 34/54 (62%)

Query: 638 GTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVT 691
           G V+Y+G T FA G W G+ L    GKNDG+VG  RYF C    G+  RPS++T
Sbjct: 93  GVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLT 146


>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
          Length = 3117

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 60/229 (26%), Positives = 113/229 (49%), Gaps = 26/229 (11%)

Query: 397  SASESTLSLPPGEEL-KTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMS 455
            S++    S    EE+ + ++EK +++  +V S          +    K+ +   +++ ++
Sbjct: 2421 SSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVT 2480

Query: 456  KSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWY 515
            +SPSL+S            TA+      +  +G+RVL+   + G +RF G T+FA G+W 
Sbjct: 2481 ESPSLAS----------VPTADELF---DFHIGDRVLIGNVQPGILRFKGETSFAKGFWA 2527

Query: 516  GIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHS--- 572
            G+EL+KP G N+G+  G+ YF C  ++GIFAPP ++  + ++ D   +I+ ++  +S   
Sbjct: 2528 GVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDER 2587

Query: 573  YPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSV 621
            Y  + +  + T     +E +    F +          S P+   IE SV
Sbjct: 2588 YQCYNQEQNDTEGPKDREKDVSEYFYE---------KSLPSVNDIEASV 2627



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 38/66 (57%), Positives = 47/66 (71%)

Query: 285  LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344
            +GDRV+I   + G LRF G T FA G WAG+ELD+PEG NNG+   + YF+C  K+GIFA
Sbjct: 2499 IGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFA 2558

Query: 345  PLSKIS 350
            P  KIS
Sbjct: 2559 PPQKIS 2564



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 4/98 (4%)

Query: 607  SWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKND 666
            S +S PTA  +      H G +VL+  + + G +R+ G T FA G W G+EL   +G N+
Sbjct: 2484 SLASVPTADEL---FDFHIGDRVLI-GNVQPGILRFKGETSFAKGFWAGVELDKPEGNNN 2539

Query: 667  GSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDEN 704
            G+     YF CK  HG+   P ++++   N    VD N
Sbjct: 2540 GTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDIN 2577


>gi|46852172 kinesin family member 13B [Homo sapiens]
          Length = 1826

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 54/150 (36%), Positives = 76/150 (50%), Gaps = 10/150 (6%)

Query: 466  AGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK 525
            AG  + A+ +         LR GE V V   + G +R+ G  +F  G W G+EL+ P GK
Sbjct: 1682 AGGQALASDSEEADEVPEWLREGEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSGK 1741

Query: 526  NDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSA 585
            NDGS+GG QYF C+P YG+   PSRV+R T  +       S       P  RRS +T S 
Sbjct: 1742 NDGSIGGKQYFRCNPGYGLLVRPSRVRRATGPV----RRRSTGLRLGAPEARRS-ATLSG 1796

Query: 586  SSQKEINRRNAFSKSKAA-----LRRSWSS 610
            S+    +   A +K+  +      R+SW+S
Sbjct: 1797 SATNLASLTAALAKADRSHKNPENRKSWAS 1826



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 38/68 (55%), Positives = 48/68 (70%), Gaps = 1/68 (1%)

Query: 623  LHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHG 682
            L EG  V +  +++ G VRYVGP DF  G W+G+EL    GKNDGS+G K+YF C P +G
Sbjct: 1701 LREGEFVTV-GAHKTGVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYG 1759

Query: 683  VLVRPSRV 690
            +LVRPSRV
Sbjct: 1760 LLVRPSRV 1767



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 31/72 (43%), Positives = 45/72 (62%)

Query: 283  LKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGI 342
            L+ G+ V +   K G +R+ G  +F  G W G+ELD P GKN+GS+G  QYF+C P YG+
Sbjct: 1701 LREGEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGL 1760

Query: 343  FAPLSKISKAKG 354
                S++ +A G
Sbjct: 1761 LVRPSRVRRATG 1772


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 51/160 (31%), Positives = 80/160 (50%), Gaps = 7/160 (4%)

Query: 462 SRASAGLNSSATSTANNSRCEGELRLGERVLVVGQ-RLGTIRFFGTTNFAPGYWYGIELE 520
           SR  +G   SA ++A        LR+G RV V+G+   GT+ + G T FA G W G+ L+
Sbjct: 10  SRTPSGSRMSAEASAR------PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILD 63

Query: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
           +  GKNDG+V G +YF+C   +GIF   S++Q   D  DT S  + +           + 
Sbjct: 64  EAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTD 123

Query: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGS 620
           +T   S  + +  + A +  K   RR   + P + G+ G+
Sbjct: 124 TTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGA 163



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/89 (42%), Positives = 52/89 (58%), Gaps = 3/89 (3%)

Query: 605 RRSWSSTPTAGGIEGSVK---LHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSA 661
           R  +S TP+   +        L  GS+V +      GTV YVG T FA+G W+G+ L  A
Sbjct: 6   RHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEA 65

Query: 662 KGKNDGSVGDKRYFTCKPNHGVLVRPSRV 690
           KGKNDG+V  ++YFTC   HG+ VR S++
Sbjct: 66  KGKNDGTVQGRKYFTCDEGHGIFVRQSQI 94



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 52/162 (32%), Positives = 80/162 (49%), Gaps = 5/162 (3%)

Query: 283 LKLGDRVVIAGQ-KVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYG 341
           L++G RV + G+   GT+ + G T FA+G+W G+ LDE +GKN+G+V   +YF C   +G
Sbjct: 27  LRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHG 86

Query: 342 IFAPLSKISKAK-GRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
           IF   S+I   + G       TP + A+  +++ +  D    TSK+  GL   K  +A +
Sbjct: 87  IFVRQSQIQVFEDGADTTSPETPDSSAS-KVLKREGTDTTAKTSKLR-GLKPKKAPTARK 144

Query: 401 STLSLP-PGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYP 441
           +T   P P     T      + LG   S S+        S P
Sbjct: 145 TTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTP 186


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 52/160 (32%), Positives = 81/160 (50%), Gaps = 9/160 (5%)

Query: 462 SRASAGLNSSATSTANNSRCEGELRLGERVLVVGQ-RLGTIRFFGTTNFAPGYWYGIELE 520
           SR  +G   SA ++A        LR+G RV V+G+   GT+ + G T FA G W G+ L+
Sbjct: 10  SRTPSGSRMSAEASAR------PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILD 63

Query: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
           +  GKNDG+V G +YF+C   +GIF   S++Q   D  DT S       + +    +R  
Sbjct: 64  EAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTS--PETPDSSASKVLKREG 121

Query: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGS 620
           + T+A + K   R  +   + A+     S + +AG +  S
Sbjct: 122 TDTTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSS 161



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/89 (42%), Positives = 52/89 (58%), Gaps = 3/89 (3%)

Query: 605 RRSWSSTPTAGGIEGSVK---LHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSA 661
           R  +S TP+   +        L  GS+V +      GTV YVG T FA+G W+G+ L  A
Sbjct: 6   RHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEA 65

Query: 662 KGKNDGSVGDKRYFTCKPNHGVLVRPSRV 690
           KGKNDG+V  ++YFTC   HG+ VR S++
Sbjct: 66  KGKNDGTVQGRKYFTCDEGHGIFVRQSQI 94



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 42/121 (34%), Positives = 67/121 (55%), Gaps = 3/121 (2%)

Query: 283 LKLGDRVVIAGQ-KVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYG 341
           L++G RV + G+   GT+ + G T FA+G+W G+ LDE +GKN+G+V   +YF C   +G
Sbjct: 27  LRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHG 86

Query: 342 IFAPLSKISKAK-GRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
           IF   S+I   + G       TP + A+  +++ +  D    TSK+ T   ++    AS 
Sbjct: 87  IFVRQSQIQVFEDGADTTSPETPDSSAS-KVLKREGTDTTAKTSKLPTRPASTGVAGASS 145

Query: 401 S 401
           S
Sbjct: 146 S 146


>gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]
          Length = 244

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 10/116 (8%)

Query: 438 QSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQ- 496
           +S+ K+      N++  ++  + +++  A   + A+S    SRCE        V   GQ 
Sbjct: 122 RSFLKRSKLGRYNEEERAQQEAEAAQRLAEEKAQASSIPVGSRCE--------VRAAGQS 173

Query: 497 -RLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRV 551
            R GT+ + G T+F PGYW G+  ++P GKNDGSV G +YF C  +YG F  P+ V
Sbjct: 174 PRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAVV 229



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 30/58 (51%), Positives = 36/58 (62%)

Query: 634 SNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVT 691
           S   GTV YVG TDF  G W+G+      GKNDGSV  KRYF C+  +G  V+P+ VT
Sbjct: 173 SPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAVVT 230



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 31/71 (43%), Positives = 42/71 (59%), Gaps = 2/71 (2%)

Query: 275 KAMLTSLGLKLGDRVVIAGQ--KVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQ 332
           KA  +S+ +     V  AGQ  + GT+ + G T+F  G W G+  DEP GKN+GSV   +
Sbjct: 153 KAQASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKR 212

Query: 333 YFKCAPKYGIF 343
           YF+C  KYG F
Sbjct: 213 YFECQAKYGAF 223


>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform b [Homo sapiens]
          Length = 618

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 5/99 (5%)

Query: 135 LIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIA 194
           LI +GA +  + R +   ALH AA     ELIR+ L+             +N  TALH+A
Sbjct: 498 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSF-VNAKAYNGNTALHVA 556

Query: 195 A---YNLCA-GAVKCLLEQGANPAFRNDKGQIPADVVPD 229
           A   Y L    AV+ L+ +GA+P+ RN + + P  +VPD
Sbjct: 557 ASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 595


>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform a [Homo sapiens]
          Length = 718

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 5/99 (5%)

Query: 135 LIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIA 194
           LI +GA +  + R +   ALH AA     ELIR+ L+             +N  TALH+A
Sbjct: 598 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSF-VNAKAYNGNTALHVA 656

Query: 195 A---YNLCA-GAVKCLLEQGANPAFRNDKGQIPADVVPD 229
           A   Y L    AV+ L+ +GA+P+ RN + + P  +VPD
Sbjct: 657 ASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695


>gi|118442828 beta-tubulin cofactor E [Homo sapiens]
          Length = 527

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 31/77 (40%), Positives = 40/77 (51%), Gaps = 3/77 (3%)

Query: 487 LGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKP-HGKNDGSVGGVQYFSC-SPRYGI 544
           +G RV V G+   T+RF G      G W G+E + P  GK+DGS  G  YF C  P  G 
Sbjct: 10  IGRRVEVNGEH-ATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 545 FAPPSRVQRVTDSLDTL 561
           F  P++V   TD L  +
Sbjct: 69  FIRPNKVNFGTDFLTAI 85



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 3/68 (4%)

Query: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPE-GKNNGSVGKVQYFKCA-PKYGI 342
           +G RV + G+   T+RF G     +G W G+E D PE GK++GS     YFKC  P  G 
Sbjct: 10  IGRRVEVNGEHA-TVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 343 FAPLSKIS 350
           F   +K++
Sbjct: 69  FIRPNKVN 76



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 2/61 (3%)

Query: 634 SNEMGTVRYVGPTDFASGIWLGLEL-RSAKGKNDGSVGDKRYFTCK-PNHGVLVRPSRVT 691
           + E  TVR+ G     +G WLG+E     +GK+DGS     YF C+ P  G  +RP++V 
Sbjct: 17  NGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNKVN 76

Query: 692 Y 692
           +
Sbjct: 77  F 77


>gi|4507375 beta-tubulin cofactor E [Homo sapiens]
          Length = 527

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 31/77 (40%), Positives = 40/77 (51%), Gaps = 3/77 (3%)

Query: 487 LGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKP-HGKNDGSVGGVQYFSC-SPRYGI 544
           +G RV V G+   T+RF G      G W G+E + P  GK+DGS  G  YF C  P  G 
Sbjct: 10  IGRRVEVNGEH-ATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 545 FAPPSRVQRVTDSLDTL 561
           F  P++V   TD L  +
Sbjct: 69  FIRPNKVNFGTDFLTAI 85



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 3/68 (4%)

Query: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPE-GKNNGSVGKVQYFKCA-PKYGI 342
           +G RV + G+   T+RF G     +G W G+E D PE GK++GS     YFKC  P  G 
Sbjct: 10  IGRRVEVNGEHA-TVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 343 FAPLSKIS 350
           F   +K++
Sbjct: 69  FIRPNKVN 76



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 2/61 (3%)

Query: 634 SNEMGTVRYVGPTDFASGIWLGLEL-RSAKGKNDGSVGDKRYFTCK-PNHGVLVRPSRVT 691
           + E  TVR+ G     +G WLG+E     +GK+DGS     YF C+ P  G  +RP++V 
Sbjct: 17  NGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNKVN 76

Query: 692 Y 692
           +
Sbjct: 77  F 77


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 43/171 (25%), Positives = 79/171 (46%), Gaps = 17/171 (9%)

Query: 55  SCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIGNEIL--KRGCNVNDRDGLTDMTLLH 112
           S  E+L + K  V+  F  +++ +  +  N   +   +L  K+G N N +D ++  T LH
Sbjct: 45  SVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQD-ISGCTPLH 103

Query: 113 YTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKT 172
              ++G           K  ++L++  AD+++ +    + A+H+ A     EL+  +++ 
Sbjct: 104 LAARNGQK---------KCMSKLLEYSADVNICNN-EGLTAIHWLAVNGRTELLHDLVQH 153

Query: 173 SKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIP 223
               DV+         TALH+A  N     V+CLL+ GA+    N  G  P
Sbjct: 154 VSDVDVEDAMGQ----TALHVACQNGHKTTVQCLLDSGADINRPNVSGATP 200


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 61/235 (25%), Positives = 92/235 (39%), Gaps = 43/235 (18%)

Query: 101 DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYF 160
           D  G T + L    C+ G  G+  +  +      L++     +     T+   LH AA  
Sbjct: 145 DNSGKTPLDL---ACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTS--PLHLAAKN 199

Query: 161 DVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKG 220
              ++IR++L+     D++        GTALH AA       V+ LL+ G N   RN   
Sbjct: 200 GHIDIIRLLLQAGI--DINRQTKS---GTALHEAALCGKTEVVRLLLDSGINAHVRNTYS 254

Query: 221 QIPADVVPDPVDMPLEMADAAATAKEIKQMLLDA-VPLSCNISKAMLPNYDHVTGKAMLT 279
           Q   D+V             +  ++EIKQ+L +A   L    +K    NYD       LT
Sbjct: 255 QTALDIV--------HQFTTSQASREIKQLLREASAALQVRATKDYCNNYD-------LT 299

Query: 280 SLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYF 334
           SL +K GD + +  Q               G+W G   D   G +     +V YF
Sbjct: 300 SLNVKAGDIITVLEQ------------HPDGRWKGCIHDNRTGND-----RVGYF 337



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 30/133 (22%), Positives = 57/133 (42%), Gaps = 17/133 (12%)

Query: 94  KRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNA 153
           K   N  D DG +    LH+   +G           +  + L++  A + ++     M  
Sbjct: 39  KINVNFQDPDGFS---ALHHAALNGN---------TELISLLLEAQAAVDIKDN-KGMRP 85

Query: 154 LHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANP 213
           LHYAA+    E ++++LK     ++ +          LH+AA +      + LL+  +NP
Sbjct: 86  LHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHI----PLHLAAQHGHYDVSEMLLQHQSNP 141

Query: 214 AFRNDKGQIPADV 226
              ++ G+ P D+
Sbjct: 142 CMVDNSGKTPLDL 154


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
           isoform b [Homo sapiens]
          Length = 1176

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 30/105 (28%), Positives = 49/105 (46%), Gaps = 5/105 (4%)

Query: 129 VKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFG 188
           ++    L+  GAD++L     N+  LH+A++     +  V+L        D    +++  
Sbjct: 764 IEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLLNAR----CDLHAVNYHGD 818

Query: 189 TALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDM 233
           T LHIAA       V   L +GANP  RN +G    D+ P+  D+
Sbjct: 819 TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
           isoform a [Homo sapiens]
          Length = 1210

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 30/105 (28%), Positives = 49/105 (46%), Gaps = 5/105 (4%)

Query: 129 VKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFG 188
           ++    L+  GAD++L     N+  LH+A++     +  V+L        D    +++  
Sbjct: 798 IEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLLNAR----CDLHAVNYHGD 852

Query: 189 TALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDM 233
           T LHIAA       V   L +GANP  RN +G    D+ P+  D+
Sbjct: 853 TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897


>gi|140161500 ankyrin repeat and sterile alpha motif domain
           containing 1 [Homo sapiens]
          Length = 1134

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 49/171 (28%), Positives = 71/171 (41%), Gaps = 26/171 (15%)

Query: 95  RGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNAL 154
           RG NVN  D  T  T LH+   +G   + +V       T + D                L
Sbjct: 69  RGPNVNCVDS-TGYTPLHHAALNGHKDVVEVLLRNDALTNVADS----------KGCYPL 117

Query: 155 HYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPA 214
           H AA+    +++R+++    P        + +  TALH AA       VK LLE+  +P 
Sbjct: 118 HLAAWKGDAQIVRLLIHQG-PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT 176

Query: 215 FRNDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVP--LSCNISK 263
            RN+K + P D+             A     E+ +MLL+A P  LSCN  K
Sbjct: 177 MRNNKFETPLDLA------------ALYGRLEVVKMLLNAHPNLLSCNTKK 215


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 17/129 (13%)

Query: 98  NVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYA 157
           NV+DR G    T LH+   SG HG        +    L+  GA+I+   +  +  A+H+A
Sbjct: 134 NVSDRAG---RTALHHAAFSG-HG--------EMVKLLLSRGANINAFDK-KDRRAIHWA 180

Query: 158 AYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRN 217
           AY    E++++++        + TC D    T LH AA +     VK LL+ G +    N
Sbjct: 181 AYMGHIEVVKLLVSHG----AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236

Query: 218 DKGQIPADV 226
             G  P  V
Sbjct: 237 AYGNTPLHV 245



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 39/138 (28%), Positives = 60/138 (43%), Gaps = 14/138 (10%)

Query: 86  DIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLR 145
           D++ NE++  G  VN ++     T LH+   S  HG   +E        L+  GAD++++
Sbjct: 252 DVVVNELIDCGAIVNQKNE-KGFTPLHFAAAS-THGALCLEL-------LVGNGADVNMK 302

Query: 146 SRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKC 205
           S+      LH  A        + I+++    D    C D N  T LHIAA       +  
Sbjct: 303 SK-DGKTPLHMTALHGRFSRSQTIIQSGAVID----CEDKNGNTPLHIAARYGHELLINT 357

Query: 206 LLEQGANPAFRNDKGQIP 223
           L+  GA+ A R   G  P
Sbjct: 358 LITSGADTAKRGIHGMFP 375



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 15/132 (11%)

Query: 92  ILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNM 151
           +L RG N+N  D   D   +H+    G          ++    L+  GA+++ + +  + 
Sbjct: 159 LLSRGANINAFDK-KDRRAIHWAAYMGH---------IEVVKLLVSHGAEVTCKDK-KSY 207

Query: 152 NALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGA 211
             LH AA   +  +++ +L       VD    +    T LH+A YN     V  L++ GA
Sbjct: 208 TPLHAAASSGMISVVKYLLDLG----VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263

Query: 212 NPAFRNDKGQIP 223
               +N+KG  P
Sbjct: 264 IVNQKNEKGFTP 275



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 39/140 (27%), Positives = 59/140 (42%), Gaps = 20/140 (14%)

Query: 96  GCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALH 155
           G +VND D     T LHY   S   G        K    L+   A+  +R +    NA+H
Sbjct: 461 GASVNDLDE-RGCTPLHYAATSDTDG--------KCLEYLLRNDANPGIRDK-QGYNAVH 510

Query: 156 YAAYFDVPELIRVILKTSKPKDV-------DATCSDFNFGTA--LHIAAYNLCAGAVKCL 206
           Y+A +    L   ++ +  P DV       D      N  T   LH+AAY+    A++ L
Sbjct: 511 YSAAYG-HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVL 569

Query: 207 LEQGANPAFRNDKGQIPADV 226
           ++   +   RN  G+ P D+
Sbjct: 570 VQSLLDLDVRNSSGRTPLDL 589



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 28/72 (38%), Positives = 37/72 (51%), Gaps = 10/72 (13%)

Query: 135 LIDLGADISLR-SRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHI 193
           LI  GA ++ + S+W  +  LH A      E ++V+LK S     D    D N+ T LHI
Sbjct: 60  LILSGARVNAKDSKW--LTPLHRAVASCSEEAVQVLLKHS----ADVNARDKNWQTPLHI 113

Query: 194 AAYNLCAGAVKC 205
           AA N    AVKC
Sbjct: 114 AAAN---KAVKC 122



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 11/118 (9%)

Query: 92  ILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNM 151
           +L +G NV+ +D     T LH    +G     D          L+  GA   LR      
Sbjct: 672 LLNKGANVDAKDKW-GRTALHRGAVTGHEECVDA---------LLQHGAKCLLRDS-RGR 720

Query: 152 NALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209
             +H +A      ++  +L+++   D +   +D +  TALH A YN     V+ LLEQ
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/137 (30%), Positives = 67/137 (48%), Gaps = 19/137 (13%)

Query: 92  ILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWT 149
           +L RG  ++   RDGLT    LH   +SG   + ++         L++ GA +  R++  
Sbjct: 264 LLDRGGQIDAKTRDGLTP---LHCAARSGHDQVVEL---------LLERGAPLLARTK-N 310

Query: 150 NMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209
            ++ LH AA  D  E ++ +L+   P D D T    ++ TALH+AA+       K LL++
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVD-DVT---LDYLTALHVAAHCGHYRVTKLLLDK 366

Query: 210 GANPAFRNDKGQIPADV 226
            ANP  R   G  P  +
Sbjct: 367 RANPNARALNGFTPLHI 383



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 19/138 (13%)

Query: 91  EILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRW 148
           E LK G ++N  +++GL     LH   K G  G+           +L+  G+ +   ++ 
Sbjct: 28  EYLKGGIDINTCNQNGLN---ALHLAAKEGHVGL---------VQELLGRGSSVDSATKK 75

Query: 149 TNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLE 208
            N  ALH A+     E+++V++K    +  +      N  T L++AA       VK LLE
Sbjct: 76  GN-TALHIASLAGQAEVVKVLVK----EGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 209 QGANPAFRNDKGQIPADV 226
            GAN +   + G  P  V
Sbjct: 131 NGANQSTATEDGFTPLAV 148



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 15/135 (11%)

Query: 92  ILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNM 151
           +L +  N N R  L   T LH  CK         +  +K    L+  GA I   +  + +
Sbjct: 363 LLDKRANPNAR-ALNGFTPLHIACK---------KNRIKVMELLVKYGASIQAITE-SGL 411

Query: 152 NALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGA 211
             +H AA+     ++ ++L+     DV    ++    TALH+AA       V+CLL  GA
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDV----TNIRGETALHMAARAGQVEVVRCLLRNGA 467

Query: 212 NPAFRNDKGQIPADV 226
               R  + Q P  +
Sbjct: 468 LVDARAREEQTPLHI 482



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 14/118 (11%)

Query: 109 TLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRV 168
           T LH   ++G          V+    L+  GA +  R+R      LH A+     E++++
Sbjct: 445 TALHMAARAGQ---------VEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQL 494

Query: 169 ILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           +L+     D   T    N  T LHI+A          LLE GA  +    KG  P  V
Sbjct: 495 LLQHMAHPDAATT----NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 126 ETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDF 185
           E  V  A+ L++ GA  SL ++      LH AA +   ++ +++L+     D     +  
Sbjct: 519 EGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD----SAGK 573

Query: 186 NFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           N  T LH+AA+         LLE+GA+P      G  P  +
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 614


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/137 (30%), Positives = 67/137 (48%), Gaps = 19/137 (13%)

Query: 92  ILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWT 149
           +L RG  ++   RDGLT    LH   +SG   + ++         L++ GA +  R++  
Sbjct: 285 LLDRGGQIDAKTRDGLTP---LHCAARSGHDQVVEL---------LLERGAPLLARTK-N 331

Query: 150 NMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209
            ++ LH AA  D  E ++ +L+   P D D T    ++ TALH+AA+       K LL++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVD-DVT---LDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 210 GANPAFRNDKGQIPADV 226
            ANP  R   G  P  +
Sbjct: 388 RANPNARALNGFTPLHI 404



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 19/138 (13%)

Query: 91  EILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRW 148
           E LK G ++N  +++GL     LH   K G  G+           +L+  G+ +   ++ 
Sbjct: 49  EYLKGGIDINTCNQNGLN---ALHLAAKEGHVGL---------VQELLGRGSSVDSATKK 96

Query: 149 TNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLE 208
            N  ALH A+     E+++V++K    +  +      N  T L++AA       VK LLE
Sbjct: 97  GN-TALHIASLAGQAEVVKVLVK----EGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 209 QGANPAFRNDKGQIPADV 226
            GAN +   + G  P  V
Sbjct: 152 NGANQSTATEDGFTPLAV 169



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 15/135 (11%)

Query: 92  ILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNM 151
           +L +  N N R  L   T LH  CK         +  +K    L+  GA I   +  + +
Sbjct: 384 LLDKRANPNAR-ALNGFTPLHIACK---------KNRIKVMELLVKYGASIQAITE-SGL 432

Query: 152 NALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGA 211
             +H AA+     ++ ++L+     DV    ++    TALH+AA       V+CLL  GA
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDV----TNIRGETALHMAARAGQVEVVRCLLRNGA 488

Query: 212 NPAFRNDKGQIPADV 226
               R  + Q P  +
Sbjct: 489 LVDARAREEQTPLHI 503



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 14/118 (11%)

Query: 109 TLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRV 168
           T LH   ++G          V+    L+  GA +  R+R      LH A+     E++++
Sbjct: 466 TALHMAARAGQ---------VEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQL 515

Query: 169 ILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           +L+     D   T    N  T LHI+A          LLE GA  +    KG  P  V
Sbjct: 516 LLQHMAHPDAATT----NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 126 ETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDF 185
           E  V  A+ L++ GA  SL ++      LH AA +   ++ +++L+     D     +  
Sbjct: 540 EGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD----SAGK 594

Query: 186 NFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           N  T LH+AA+         LLE+GA+P      G  P  +
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/137 (30%), Positives = 67/137 (48%), Gaps = 19/137 (13%)

Query: 92  ILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWT 149
           +L RG  ++   RDGLT    LH   +SG   + ++         L++ GA +  R++  
Sbjct: 285 LLDRGGQIDAKTRDGLTP---LHCAARSGHDQVVEL---------LLERGAPLLARTK-N 331

Query: 150 NMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209
            ++ LH AA  D  E ++ +L+   P D D T    ++ TALH+AA+       K LL++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVD-DVT---LDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 210 GANPAFRNDKGQIPADV 226
            ANP  R   G  P  +
Sbjct: 388 RANPNARALNGFTPLHI 404



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 19/138 (13%)

Query: 91  EILKRGCNVN--DRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRW 148
           E LK G ++N  +++GL     LH   K G  G+           +L+  G+ +   ++ 
Sbjct: 49  EYLKGGIDINTCNQNGLN---ALHLAAKEGHVGL---------VQELLGRGSSVDSATKK 96

Query: 149 TNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLE 208
            N  ALH A+     E+++V++K    +  +      N  T L++AA       VK LLE
Sbjct: 97  GN-TALHIASLAGQAEVVKVLVK----EGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 209 QGANPAFRNDKGQIPADV 226
            GAN +   + G  P  V
Sbjct: 152 NGANQSTATEDGFTPLAV 169



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 15/135 (11%)

Query: 92  ILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNM 151
           +L +  N N R  L   T LH  CK         +  +K    L+  GA I   +  + +
Sbjct: 384 LLDKRANPNAR-ALNGFTPLHIACK---------KNRIKVMELLVKYGASIQAITE-SGL 432

Query: 152 NALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGA 211
             +H AA+     ++ ++L+     DV    ++    TALH+AA       V+CLL  GA
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDV----TNIRGETALHMAARAGQVEVVRCLLRNGA 488

Query: 212 NPAFRNDKGQIPADV 226
               R  + Q P  +
Sbjct: 489 LVDARAREEQTPLHI 503



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 14/118 (11%)

Query: 109 TLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRV 168
           T LH   ++G          V+    L+  GA +  R+R      LH A+     E++++
Sbjct: 466 TALHMAARAGQ---------VEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQL 515

Query: 169 ILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           +L+     D   T    N  T LHI+A          LLE GA  +    KG  P  V
Sbjct: 516 LLQHMAHPDAATT----NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 126 ETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDF 185
           E  V  A+ L++ GA  SL ++      LH AA +   ++ +++L+     D     +  
Sbjct: 540 EGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD----SAGK 594

Query: 186 NFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADV 226
           N  T LH+AA+         LLE+GA+P      G  P  +
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 9/115 (7%)

Query: 134 QLIDLGADISLR--SRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTAL 191
           +LI  GAD++++  + WT ++      Y+DV + +         K +D         T L
Sbjct: 186 ELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDD-------TPL 238

Query: 192 HIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKE 246
           H AA N     VK LL  G NP   N KG+ P  V   P  + L +     T+ E
Sbjct: 239 HDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSE 293


>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
           isoform 2 [Homo sapiens]
          Length = 318

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 39/133 (29%), Positives = 64/133 (48%), Gaps = 11/133 (8%)

Query: 91  EILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTN 150
           ++L++G + N RD     TLLH++   G       E  V+     ++ GAD +++     
Sbjct: 32  KMLEQGYSPNGRDA-NGWTLLHFSAARGK------ERCVRV---FLEHGADPTVKDLIGG 81

Query: 151 MNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQG 210
             ALHYAA      + R++L++    D+    S+  + T LH+AA+      V+ LLE  
Sbjct: 82  FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGW-TPLHVAAHYGRDSFVRLLLEFK 140

Query: 211 ANPAFRNDKGQIP 223
           A     +DKG  P
Sbjct: 141 AEVDPLSDKGTTP 153


>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
           isoform 1 [Homo sapiens]
          Length = 274

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 39/133 (29%), Positives = 64/133 (48%), Gaps = 11/133 (8%)

Query: 91  EILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTN 150
           ++L++G + N RD     TLLH++   G       E  V+     ++ GAD +++     
Sbjct: 32  KMLEQGYSPNGRDA-NGWTLLHFSAARGK------ERCVRV---FLEHGADPTVKDLIGG 81

Query: 151 MNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQG 210
             ALHYAA      + R++L++    D+    S+  + T LH+AA+      V+ LLE  
Sbjct: 82  FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGW-TPLHVAAHYGRDSFVRLLLEFK 140

Query: 211 ANPAFRNDKGQIP 223
           A     +DKG  P
Sbjct: 141 AEVDPLSDKGTTP 153


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 24/132 (18%)

Query: 129 VKFATQLIDLGADISLR--SRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFN 186
           VK   +LI LGA+++++  + WT ++      Y+DV +++            D      +
Sbjct: 175 VKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA-------GADVNTQGLD 227

Query: 187 FGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKE 246
             T LH +A +     VK LL  G NP   N  G+ P DV               A  +E
Sbjct: 228 DDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDV---------------AETEE 272

Query: 247 IKQMLLDAVPLS 258
           ++ +L   VPLS
Sbjct: 273 LELLLKREVPLS 284


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 24/132 (18%)

Query: 129 VKFATQLIDLGADISLR--SRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFN 186
           VK   +LI LGA+++++  + WT ++      Y+DV +++            D      +
Sbjct: 198 VKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA-------GADVNTQGLD 250

Query: 187 FGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKE 246
             T LH +A +     VK LL  G NP   N  G+ P DV               A  +E
Sbjct: 251 DDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDV---------------AETEE 295

Query: 247 IKQMLLDAVPLS 258
           ++ +L   VPLS
Sbjct: 296 LELLLKREVPLS 307


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 30/160 (18%)

Query: 98  NVNDRDGL-TDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHY 156
           N+N RD    + T LH      A G  ++E A      L++ GAD++ + +   +  LH 
Sbjct: 827 NINCRDTQGRNSTPLHL-----AAGYNNLEVA----EYLLEHGADVNAQDKG-GLIPLHN 876

Query: 157 AAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFR 216
           AA +   ++  +++K +    V+AT  D    T LH AA          LL  GA+P  +
Sbjct: 877 AASYGHVDIAALLIKYNTC--VNAT--DKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932

Query: 217 NDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVP 256
           N +GQ P D+               ATA +I+ +L+DA+P
Sbjct: 933 NQEGQTPLDL---------------ATADDIRALLIDAMP 957



 Score = 37.4 bits (85), Expect = 0.048
 Identities = 52/209 (24%), Positives = 85/209 (40%), Gaps = 24/209 (11%)

Query: 63  PKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGL-TDMTLLHYTCKSGAHG 121
           P T V  +   LR+ + +  +N D+   + L    NVN +D      + LH+    G   
Sbjct: 172 PGTGVPAVSGALRELL-EACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKD 230

Query: 122 IGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDAT 181
           + +          L+ +GA++  R     +  LH A  F   E++ ++L     +  D  
Sbjct: 231 VVE---------HLLQMGANVHARDDG-GLIPLHNACSFGHAEVVSLLLC----QGADPN 276

Query: 182 CSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPL------ 235
             D    T LH AA          LL+ GA+P  RN  G+   D+        L      
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336

Query: 236 -EMADAAATAKEIKQM-LLDAVPLSCNIS 262
            E+ +AA +  E K M LL  + ++C+ S
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHAS 365



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 52/179 (29%), Positives = 76/179 (42%), Gaps = 37/179 (20%)

Query: 91  EILKRGC---NVNDRD-GLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRS 146
           E +K+ C   NVN RD      T LH+   +G + +  VE        L+  GAD+  + 
Sbjct: 664 ETVKQLCSSQNVNCRDLEGRHSTPLHFA--AGYNRVSVVE-------YLLHHGADVHAKD 714

Query: 147 RWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAA----YNLCAGA 202
           +   +  LH A  +   E+  ++++     +V    +D    T LH AA    Y +C   
Sbjct: 715 KG-GLVPLHNACSYGHYEVAELLVRHGASVNV----ADLWKFTPLHEAAAKGKYEIC--- 766

Query: 203 VKCLLEQGANPAFRNDKGQIPADVVP--DPVDMPLEMADAAATAKEIKQMLLDAVPLSC 259
            K LL+ GA+P  +N  G  P D+V   D     L   DAA         LLDA    C
Sbjct: 767 -KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAA---------LLDAAKKGC 815



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 35/147 (23%), Positives = 57/147 (38%), Gaps = 11/147 (7%)

Query: 90  NEILKRGCNVNDRDGLTDMTLLHYTC------KSGAHGIGDVETAVKFATQLIDLGADIS 143
           +E+L+   + N+   +  +T L+  C      KS    +      V+    L+  GAD+ 
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396

Query: 144 LRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAV 203
            + +   +  LH A  +   E+  ++LK            D    T LH AA        
Sbjct: 397 AKDKG-GLVPLHNACSYGHYEVTELLLKHG----ACVNAMDLWQFTPLHEAASKNRVEVC 451

Query: 204 KCLLEQGANPAFRNDKGQIPADVVPDP 230
             LL  GA+P   N  G+   D+ P P
Sbjct: 452 SLLLSHGADPTLVNCHGKSAVDMAPTP 478


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,297,682
Number of Sequences: 37866
Number of extensions: 1148425
Number of successful extensions: 4293
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 3831
Number of HSP's gapped (non-prelim): 536
length of query: 705
length of database: 18,247,518
effective HSP length: 109
effective length of query: 596
effective length of database: 14,120,124
effective search space: 8415593904
effective search space used: 8415593904
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press