Guide to the Human Genome
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Search of human proteins with 31742516

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31742516 frataxin isoform 2 preproprotein [Homo sapiens]
         (196 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31742516 frataxin isoform 2 preproprotein [Homo sapiens]           402   e-113
gi|239787198 frataxin isoform 3 preproprotein [Homo sapiens]          327   3e-90
gi|31077081 frataxin isoform 1 preproprotein [Homo sapiens]           325   1e-89
gi|124001558 ubiquitin specific peptidase 54 [Homo sapiens]            32   0.35 
gi|169164783 PREDICTED: hypothetical protein [Homo sapiens]            31   0.77 
gi|169163482 PREDICTED: hypothetical protein [Homo sapiens]            31   0.77 
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]             30   1.0  
gi|9506363 SAM and SH3 domain containing 3 [Homo sapiens]              30   1.3  
gi|47458820 signal transducer and activator of transcription 3 i...    30   1.3  
gi|21618338 signal transducer and activator of transcription 3 i...    30   1.3  
gi|21618340 signal transducer and activator of transcription 3 i...    30   1.3  
gi|239751624 PREDICTED: hypothetical protein XP_002347938 [Homo ...    29   2.2  
gi|239746135 PREDICTED: hypothetical protein XP_002344205 [Homo ...    29   2.2  
gi|89941479 hypothetical protein LOC148137 [Homo sapiens]              29   2.2  
gi|34486092 adenylate cyclase 5 [Homo sapiens]                         29   2.9  
gi|222446609 rai-like protein [Homo sapiens]                           28   3.8  
gi|239757070 PREDICTED: hypothetical protein [Homo sapiens]            28   3.8  
gi|239751580 PREDICTED: hypothetical protein [Homo sapiens]            28   3.8  
gi|239746092 PREDICTED: hypothetical protein XP_002343656 [Homo ...    28   3.8  
gi|169168202 PREDICTED: hypothetical protein [Homo sapiens]            28   5.0  
gi|169167967 PREDICTED: hypothetical protein [Homo sapiens]            28   5.0  
gi|169167681 PREDICTED: hypothetical protein [Homo sapiens]            28   5.0  
gi|4557485 ceruloplasmin precursor [Homo sapiens]                      28   6.5  
gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens]      27   8.5  

>gi|31742516 frataxin isoform 2 preproprotein [Homo sapiens]
          Length = 196

 Score =  402 bits (1034), Expect = e-113
 Identities = 196/196 (100%), Positives = 196/196 (100%)

Query: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60
           MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR
Sbjct: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60

Query: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120
           GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF
Sbjct: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120

Query: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRYVVDLSVMTGLGKTGCTPT 180
           EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRYVVDLSVMTGLGKTGCTPT
Sbjct: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRYVVDLSVMTGLGKTGCTPT 180

Query: 181 TACPSMSCWPQSSLKP 196
           TACPSMSCWPQSSLKP
Sbjct: 181 TACPSMSCWPQSSLKP 196


>gi|239787198 frataxin isoform 3 preproprotein [Homo sapiens]
          Length = 171

 Score =  327 bits (839), Expect = 3e-90
 Identities = 161/161 (100%), Positives = 161/161 (100%)

Query: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60
           MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR
Sbjct: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60

Query: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120
           GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF
Sbjct: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120

Query: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSR 161
           EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSR
Sbjct: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSR 161


>gi|31077081 frataxin isoform 1 preproprotein [Homo sapiens]
          Length = 210

 Score =  325 bits (834), Expect = 1e-89
 Identities = 160/160 (100%), Positives = 160/160 (100%)

Query: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60
           MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR
Sbjct: 1   MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR 60

Query: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120
           GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF
Sbjct: 61  GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF 120

Query: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPS 160
           EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPS
Sbjct: 121 EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPS 160


>gi|124001558 ubiquitin specific peptidase 54 [Homo sapiens]
          Length = 1684

 Score = 32.0 bits (71), Expect = 0.35
 Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 13/100 (13%)

Query: 29  RPAELAPLCGRRGLRTDIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLGHPG 88
           +P    PL  R     +I++T +  ++SS+ +     W  K++S+ + ++       H G
Sbjct: 543 KPPRTLPLHSRDW---EIESTSSESKSSSSSK-YRPTWRPKRESLNIDSIFSKDKRKHCG 598

Query: 89  SLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFG 128
                 Y +L+  + DS  EF  D   KP     YD+ FG
Sbjct: 599 ------YTQLSPFSEDSAKEFIPDEPSKP---PSYDIKFG 629


>gi|169164783 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 396

 Score = 30.8 bits (68), Expect = 0.77
 Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 12/88 (13%)

Query: 5   GRRAVAGLLASPSPAQAQTLTRVPRPAELAPL--CGRRGLRTDIDATCTPRRASSNQRGL 62
           G+R   GL  S  PA A++  R PRP  L P    G   LR       T R  SS+  G+
Sbjct: 19  GQRRAPGLPRSSGPAWAESRARPPRPRGLEPRHPPGSPALRP------TDRTCSSSSAGV 72

Query: 63  -NQIWNVKKQSVYL---MNLRKSGTLGH 86
              +   +  SV L   + L +  TLGH
Sbjct: 73  GGGVGGAQPGSVPLGQHLALERGRTLGH 100


>gi|169163482 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 396

 Score = 30.8 bits (68), Expect = 0.77
 Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 12/88 (13%)

Query: 5   GRRAVAGLLASPSPAQAQTLTRVPRPAELAPL--CGRRGLRTDIDATCTPRRASSNQRGL 62
           G+R   GL  S  PA A++  R PRP  L P    G   LR       T R  SS+  G+
Sbjct: 19  GQRRAPGLPRSSGPAWAESRARPPRPRGLEPRHPPGSPALRP------TDRTCSSSSAGV 72

Query: 63  -NQIWNVKKQSVYL---MNLRKSGTLGH 86
              +   +  SV L   + L +  TLGH
Sbjct: 73  GGGVGGAQPGSVPLGQHLALERGRTLGH 100


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score = 30.4 bits (67), Expect = 1.0
 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 8/89 (8%)

Query: 17   SPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRR-----ASSNQRGLNQIWNVKKQ 71
            +P++    +R+P P EL P       R+ +D+   PR      AS +   L   W++ + 
Sbjct: 1066 TPSRHSPASRIP-PPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSES 1124

Query: 72   SVYLMNLRKSG--TLGHPGSLDETTYERL 98
            S+  ++LR+S       PGS    + E L
Sbjct: 1125 SLSNLSLRRSSERLSDTPGSFQSPSLEIL 1153


>gi|9506363 SAM and SH3 domain containing 3 [Homo sapiens]
          Length = 380

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 17/43 (39%), Positives = 19/43 (44%), Gaps = 1/43 (2%)

Query: 4   LGRRAVAGL-LASPSPAQAQTLTRVPRPAELAPLCGRRGLRTD 45
           L R+A  G  L SPSP         P P    P CGR  + TD
Sbjct: 141 LSRQASTGSELCSPSPGSGSFGEEPPAPQYTGPFCGRARVHTD 183


>gi|47458820 signal transducer and activator of transcription 3
           isoform 3 [Homo sapiens]
          Length = 722

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 18/75 (24%), Positives = 33/75 (44%)

Query: 79  RKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGG 138
           ++ G   HP +   T  +++ E+ L  + +  +DL  K    E+    F     T+K  G
Sbjct: 124 QQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQG 183

Query: 139 DLGTYVINKQTPNKQ 153
           D+     N Q+  +Q
Sbjct: 184 DMQDLNGNNQSVTRQ 198


>gi|21618338 signal transducer and activator of transcription 3
           isoform 2 [Homo sapiens]
          Length = 769

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 18/75 (24%), Positives = 33/75 (44%)

Query: 79  RKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGG 138
           ++ G   HP +   T  +++ E+ L  + +  +DL  K    E+    F     T+K  G
Sbjct: 124 QQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQG 183

Query: 139 DLGTYVINKQTPNKQ 153
           D+     N Q+  +Q
Sbjct: 184 DMQDLNGNNQSVTRQ 198


>gi|21618340 signal transducer and activator of transcription 3
           isoform 1 [Homo sapiens]
          Length = 770

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 18/75 (24%), Positives = 33/75 (44%)

Query: 79  RKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGG 138
           ++ G   HP +   T  +++ E+ L  + +  +DL  K    E+    F     T+K  G
Sbjct: 124 QQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQG 183

Query: 139 DLGTYVINKQTPNKQ 153
           D+     N Q+  +Q
Sbjct: 184 DMQDLNGNNQSVTRQ 198


>gi|239751624 PREDICTED: hypothetical protein XP_002347938 [Homo
           sapiens]
          Length = 244

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 14/27 (51%), Positives = 17/27 (62%)

Query: 4   LGRRAVAGLLASPSPAQAQTLTRVPRP 30
           +GRRA AGL A P P QA  L +  +P
Sbjct: 85  VGRRAAAGLRAHPLPPQAPPLAQSSQP 111


>gi|239746135 PREDICTED: hypothetical protein XP_002344205 [Homo
           sapiens]
          Length = 244

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 14/27 (51%), Positives = 17/27 (62%)

Query: 4   LGRRAVAGLLASPSPAQAQTLTRVPRP 30
           +GRRA AGL A P P QA  L +  +P
Sbjct: 85  VGRRAAAGLRAHPLPPQAPPLAQSSQP 111


>gi|89941479 hypothetical protein LOC148137 [Homo sapiens]
          Length = 425

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 16/24 (66%), Positives = 17/24 (70%), Gaps = 1/24 (4%)

Query: 14  ASPSPAQAQTLTRVPRPA-ELAPL 36
           ASP+PAQAQT T  P PA   APL
Sbjct: 257 ASPAPAQAQTPTPAPAPASSQAPL 280


>gi|34486092 adenylate cyclase 5 [Homo sapiens]
          Length = 1261

 Score = 28.9 bits (63), Expect = 2.9
 Identities = 21/87 (24%), Positives = 40/87 (45%), Gaps = 15/87 (17%)

Query: 78   LRKSGTLGHP----GSLDETTYERLAEETLDSLAEFFEDLADK-----PYTFEDYDVSFG 128
            L K  T+G        L+++TY+++ +  + +LA+F   L D+      ++F ++ +  G
Sbjct: 1119 LEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG 1178

Query: 129  SGVLTVKLGGDLGTYVINKQTPNKQIW 155
              +  V  G      VI  + P   IW
Sbjct: 1179 LNIGPVVAG------VIGARKPQYDIW 1199


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score = 28.5 bits (62), Expect = 3.8
 Identities = 12/27 (44%), Positives = 14/27 (51%)

Query: 82  GTLGHPGSLDETTYERLAEETLDSLAE 108
           G  GHPG L    Y R   E++ SL E
Sbjct: 17  GLFGHPGMLHRAKYSRFRNESITSLDE 43


>gi|239757070 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 195

 Score = 28.5 bits (62), Expect = 3.8
 Identities = 21/57 (36%), Positives = 24/57 (42%), Gaps = 7/57 (12%)

Query: 9   VAGLLASPSPAQAQTLTRVPRPAELAP----LCGRRGLRTDIDATCTPRRASSNQRG 61
           VAG L  P P       R P+P    P    LC   GLRT  DA+   R A +   G
Sbjct: 137 VAGCLPLPRPRDG---ARSPQPLPWKPGLPSLCVASGLRTAPDASAPGRAAKTRSSG 190


>gi|239751580 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 195

 Score = 28.5 bits (62), Expect = 3.8
 Identities = 21/57 (36%), Positives = 24/57 (42%), Gaps = 7/57 (12%)

Query: 9   VAGLLASPSPAQAQTLTRVPRPAELAP----LCGRRGLRTDIDATCTPRRASSNQRG 61
           VAG L  P P       R P+P    P    LC   GLRT  DA+   R A +   G
Sbjct: 137 VAGCLPLPRPRDG---ARSPQPLPWKPGLPSLCVASGLRTAPDASAPGRAAKTRSSG 190


>gi|239746092 PREDICTED: hypothetical protein XP_002343656 [Homo
           sapiens]
          Length = 195

 Score = 28.5 bits (62), Expect = 3.8
 Identities = 21/57 (36%), Positives = 24/57 (42%), Gaps = 7/57 (12%)

Query: 9   VAGLLASPSPAQAQTLTRVPRPAELAP----LCGRRGLRTDIDATCTPRRASSNQRG 61
           VAG L  P P       R P+P    P    LC   GLRT  DA+   R A +   G
Sbjct: 137 VAGCLPLPRPRDG---ARSPQPLPWKPGLPSLCVASGLRTAPDASAPGRAAKTRSSG 190


>gi|169168202 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 460

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 11/67 (16%)

Query: 3   TLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGL 62
           TL  R+   LL SP P       R P P          GLR D D    P R   +QR +
Sbjct: 340 TLAFRSRLPLLRSPGPEGTSDAARAPAP----------GLR-DRDLRAAPPRPRPSQRPV 388

Query: 63  NQIWNVK 69
           + ++ VK
Sbjct: 389 SGLFKVK 395


>gi|169167967 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 460

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 11/67 (16%)

Query: 3   TLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGL 62
           TL  R+   LL SP P       R P P          GLR D D    P R   +QR +
Sbjct: 340 TLAFRSRLPLLRSPGPEGTSDAARAPAP----------GLR-DRDLRAAPPRPRPSQRPV 388

Query: 63  NQIWNVK 69
           + ++ VK
Sbjct: 389 SGLFKVK 395


>gi|169167681 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 460

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 11/67 (16%)

Query: 3   TLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGL 62
           TL  R+   LL SP P       R P P          GLR D D    P R   +QR +
Sbjct: 340 TLAFRSRLPLLRSPGPEGTSDAARAPAP----------GLR-DRDLRAAPPRPRPSQRPV 388

Query: 63  NQIWNVK 69
           + ++ VK
Sbjct: 389 SGLFKVK 395


>gi|4557485 ceruloplasmin precursor [Homo sapiens]
          Length = 1065

 Score = 27.7 bits (60), Expect = 6.5
 Identities = 19/77 (24%), Positives = 36/77 (46%), Gaps = 15/77 (19%)

Query: 59  QRGLNQIWNVKKQSVYLM--------NLRKSGTLGHPGSLDETTYERLAEETLDSLAEFF 110
           Q G ++I  + K+++YL          + K   LG  G +       +  ET D +    
Sbjct: 57  QNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPI-------IKAETGDKVYVHL 109

Query: 111 EDLADKPYTFEDYDVSF 127
           ++LA +PYTF  + +++
Sbjct: 110 KNLASRPYTFHSHGITY 126



 Score = 27.7 bits (60), Expect = 6.5
 Identities = 13/41 (31%), Positives = 22/41 (53%)

Query: 104 DSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYV 144
           D +   F+++A +PY+   + V   S  +T  L G+  TYV
Sbjct: 818 DKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYV 858


>gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens]
          Length = 1544

 Score = 27.3 bits (59), Expect = 8.5
 Identities = 32/113 (28%), Positives = 47/113 (41%), Gaps = 6/113 (5%)

Query: 12   LLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGL-NQIW-NVK 69
            LLA PSPAQ    +   RP+     C  RG R  I++     +    + GL ++ W  VK
Sbjct: 1370 LLAKPSPAQQTDRSSPVRPSSEKNDC-CRGKRDGINSLERKLKRRLEREGLSSERWERVK 1428

Query: 70   KQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFED 122
            K        +K   L HP  ++    ER     L   AE     +D  Y+ ++
Sbjct: 1429 KMRT---PKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQE 1478


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,846,195
Number of Sequences: 37866
Number of extensions: 346484
Number of successful extensions: 982
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 964
Number of HSP's gapped (non-prelim): 28
length of query: 196
length of database: 18,247,518
effective HSP length: 97
effective length of query: 99
effective length of database: 14,574,516
effective search space: 1442877084
effective search space used: 1442877084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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