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Search of human proteins with 31742505
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
(1114 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 2229 0.0
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 826 0.0
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 826 0.0
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 631 e-180
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 562 e-160
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 181 3e-45
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 170 8e-42
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 170 8e-42
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 156 9e-38
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 156 9e-38
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 145 2e-34
gi|193211598 pleckstrin homology domain containing, family G (wi... 128 3e-29
gi|193211596 pleckstrin homology domain containing, family G (wi... 128 3e-29
gi|193211594 pleckstrin homology domain containing, family G (wi... 128 3e-29
gi|55742734 pleckstrin homology domain containing, family G (wit... 128 3e-29
gi|193211603 pleckstrin homology domain containing, family G (wi... 127 4e-29
gi|148529025 pleckstrin homology domain containing, family G (wi... 119 2e-26
gi|71274148 pleckstrin homology domain containing, family G (wit... 109 2e-23
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 93 1e-18
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 93 1e-18
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 91 5e-18
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 86 1e-16
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 80 1e-14
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 76 2e-13
gi|55749621 pleckstrin homology domain containing, family G, mem... 70 1e-11
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 67 1e-10
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 62 2e-09
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 62 2e-09
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 60 9e-09
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 60 9e-09
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 2229 bits (5775), Expect = 0.0
Identities = 1114/1114 (100%), Positives = 1114/1114 (100%)
Query: 1 MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG 60
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
Sbjct: 1 MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG 60
Query: 61 APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR 120
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR
Sbjct: 61 APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR 120
Query: 121 IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ 180
IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ
Sbjct: 121 IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ 180
Query: 181 LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL 240
LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
Sbjct: 181 LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL 240
Query: 241 MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE 300
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE
Sbjct: 241 MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE 300
Query: 301 TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL 360
TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL
Sbjct: 301 TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL 360
Query: 361 KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW 420
KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
Sbjct: 361 KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW 420
Query: 421 DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL 480
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL
Sbjct: 421 DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL 480
Query: 481 LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH 540
LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH
Sbjct: 481 LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH 540
Query: 541 PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH 600
PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH
Sbjct: 541 PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH 600
Query: 601 HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD
Sbjct: 601 HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Query: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP
Sbjct: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
Query: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI
Sbjct: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
Query: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK
Sbjct: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK
Sbjct: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
Query: 901 KTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI 960
KTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI
Sbjct: 901 KTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI 960
Query: 961 KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED 1020
KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED
Sbjct: 961 KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED 1020
Query: 1021 CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE 1080
CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE
Sbjct: 1021 CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE 1080
Query: 1081 EERAGASTGRLAPAGATAGFQARALRPRTSAQES 1114
EERAGASTGRLAPAGATAGFQARALRPRTSAQES
Sbjct: 1081 EERAGASTGRLAPAGATAGFQARALRPRTSAQES 1114
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 826 bits (2133), Expect = 0.0
Identities = 447/988 (45%), Positives = 629/988 (63%), Gaps = 56/988 (5%)
Query: 26 DEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMT 85
DEIM Q++ PL A +I +QL ++FA LSGGRG+DG+P+ITFP++ F IPD++F NVMT
Sbjct: 84 DEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMT 143
Query: 86 YLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTF 145
YLTSIPS++ A IGFI+VIDRRRDKW+SVKAS+ RIA +FP NLQL+ +LRP+ F QRT
Sbjct: 144 YLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTL 203
Query: 146 TDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIEN 205
+DI K+ R++FK KVP+IM++SV DLHGYIDKSQLT +LGGTL+Y H +W+ RTAIE+
Sbjct: 204 SDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIES 263
Query: 206 FALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLL 265
FAL +K TAQMLQ+FG+ LA ELP + ST +L +HT ++DK +++L+L K+G ++L
Sbjct: 264 FALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVL 323
Query: 266 SCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHF 325
++E + +N +QL+N T++RLL QL+ETE AF FW++H KL QCLQL+HF
Sbjct: 324 ESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHF 383
Query: 326 EHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGD 385
E F + K LD ++ A FT IG+S+ HVE +L++ EEKS +E+A+ L+L G+
Sbjct: 384 EQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGE 443
Query: 386 QLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIY 445
QLI + HYA D+IRP+C ELRHLCD F ++ +L KSLE HR+L+ +WC+ GIY
Sbjct: 444 QLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIY 503
Query: 446 LLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKV 505
LLASQ VDKCQS++G + AL +I FL T E + Y E+E +L D +KV
Sbjct: 504 LLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKV 563
Query: 506 LQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPL 565
Q+ ++E+FH+RQ SL KLAA+QTRPVQPVAP PE+ +K+ PS +
Sbjct: 564 FQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEA-----LAKSPCPSPGI-----R 613
Query: 566 RTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIR 625
R SE +E RG + E+ ES RG+ E++ L L RR ++
Sbjct: 614 RGSENSSSEGGALRRG------PYRRAKSEMSESRQGRGSAG-EEEESLAIL--RRHVMS 664
Query: 626 DLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFL 685
+LL+TE Y++E+ +++GY MD + HL+ L N KD LFGN+ E+Y FHNR FL
Sbjct: 665 ELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFL 724
Query: 686 KELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHN 745
+ELE + PEL+ CFL+R ED QIY KY +N PR+ ++W++C DC +F CQR+LDH
Sbjct: 725 RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHK 784
Query: 746 LPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTEL 805
L L YL P QR+ KYQ+LLK +L K +++ + +L
Sbjct: 785 LSLDSYLLKPVQRITKYQLLLKEML-----------------------KYSRNCEGAEDL 821
Query: 806 QQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRY-KMKDLIR 864
Q+AL+ I ++K+ ++ L A+T ++G LGKLL+ G FSVWT HK + K+K+L R
Sbjct: 822 QEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELAR 881
Query: 865 FKPSQRQIYLFERGIVFCKIRMEPGD-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI 923
FKP QR ++L E+ ++FCK R E G+ +P YS+K+++ + + I + +G +KFEI
Sbjct: 882 FKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEI 941
Query: 924 ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQ-FEMS--------TSK 974
E YI+QA + EI+ W +EI K+L Q ++ + E S TS
Sbjct: 942 WYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTST 1001
Query: 975 GSGAGSGPWIKNMERATTSKEDPASSTG 1002
G+ IK +E K DP S G
Sbjct: 1002 SPSRGNSRNIKKLEE---RKTDPLSLEG 1026
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 826 bits (2133), Expect = 0.0
Identities = 447/988 (45%), Positives = 629/988 (63%), Gaps = 56/988 (5%)
Query: 26 DEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMT 85
DEIM Q++ PL A +I +QL ++FA LSGGRG+DG+P+ITFP++ F IPD++F NVMT
Sbjct: 31 DEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMT 90
Query: 86 YLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTF 145
YLTSIPS++ A IGFI+VIDRRRDKW+SVKAS+ RIA +FP NLQL+ +LRP+ F QRT
Sbjct: 91 YLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTL 150
Query: 146 TDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIEN 205
+DI K+ R++FK KVP+IM++SV DLHGYIDKSQLT +LGGTL+Y H +W+ RTAIE+
Sbjct: 151 SDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIES 210
Query: 206 FALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLL 265
FAL +K TAQMLQ+FG+ LA ELP + ST +L +HT ++DK +++L+L K+G ++L
Sbjct: 211 FALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVL 270
Query: 266 SCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHF 325
++E + +N +QL+N T++RLL QL+ETE AF FW++H KL QCLQL+HF
Sbjct: 271 ESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHF 330
Query: 326 EHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGD 385
E F + K LD ++ A FT IG+S+ HVE +L++ EEKS +E+A+ L+L G+
Sbjct: 331 EQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGE 390
Query: 386 QLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIY 445
QLI + HYA D+IRP+C ELRHLCD F ++ +L KSLE HR+L+ +WC+ GIY
Sbjct: 391 QLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIY 450
Query: 446 LLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKV 505
LLASQ VDKCQS++G + AL +I FL T E + Y E+E +L D +KV
Sbjct: 451 LLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKV 510
Query: 506 LQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPL 565
Q+ ++E+FH+RQ SL KLAA+QTRPVQPVAP PE+ +K+ PS +
Sbjct: 511 FQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEA-----LAKSPCPSPGI-----R 560
Query: 566 RTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIR 625
R SE +E RG + E+ ES RG+ E++ L L RR ++
Sbjct: 561 RGSENSSSEGGALRRG------PYRRAKSEMSESRQGRGSAG-EEEESLAIL--RRHVMS 611
Query: 626 DLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFL 685
+LL+TE Y++E+ +++GY MD + HL+ L N KD LFGN+ E+Y FHNR FL
Sbjct: 612 ELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFL 671
Query: 686 KELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHN 745
+ELE + PEL+ CFL+R ED QIY KY +N PR+ ++W++C DC +F CQR+LDH
Sbjct: 672 RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHK 731
Query: 746 LPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTEL 805
L L YL P QR+ KYQ+LLK +L K +++ + +L
Sbjct: 732 LSLDSYLLKPVQRITKYQLLLKEML-----------------------KYSRNCEGAEDL 768
Query: 806 QQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRY-KMKDLIR 864
Q+AL+ I ++K+ ++ L A+T ++G LGKLL+ G FSVWT HK + K+K+L R
Sbjct: 769 QEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELAR 828
Query: 865 FKPSQRQIYLFERGIVFCKIRMEPGD-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI 923
FKP QR ++L E+ ++FCK R E G+ +P YS+K+++ + + I + +G +KFEI
Sbjct: 829 FKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEI 888
Query: 924 ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQ-FEMS--------TSK 974
E YI+QA + EI+ W +EI K+L Q ++ + E S TS
Sbjct: 889 WYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTST 948
Query: 975 GSGAGSGPWIKNMERATTSKEDPASSTG 1002
G+ IK +E K DP S G
Sbjct: 949 SPSRGNSRNIKKLEE---RKTDPLSLEG 973
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 631 bits (1627), Expect = e-180
Identities = 358/934 (38%), Positives = 541/934 (57%), Gaps = 52/934 (5%)
Query: 47 RQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDR 106
+ A LSGGRG+D A IITFPE F+ IP+E V+TYLTSI + F +++DR
Sbjct: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
Query: 107 RRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMV 166
R D WSS+K SL +I+ +FPGNL L+ +LRP+ F+QRTFTDIG + + +F K+P++M+
Sbjct: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
Query: 167 NSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLAT 226
+SVSDL YID QLT ELGGTL+Y H +W+ R AIENFALT+K AQMLQ+FG+ LA
Sbjct: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
Query: 227 AELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATK-CPNSKLNLNQ- 284
ELP + S E++L + L++++ + K+G LL+ ++ P T+ +S+L ++
Sbjct: 182 TELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQ 241
Query: 285 -LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQ 343
+ T+ +LL Q+ + E AF FW +H LK+ Q LQL FE DF + ++ LL +Q
Sbjct: 242 ISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQ 301
Query: 344 AEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCV 403
AE + ++ V+Q +K+ + L+E SQE L KAQ + L G +L +HHYA D I RC
Sbjct: 302 AELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCN 361
Query: 404 ELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDI 463
ELR+L D +N K K L ++ + H+ L + Q C+ G LLA+Q +DK QS+E
Sbjct: 362 ELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQK 421
Query: 464 ALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSL 523
AL DI FL + P+ EF+++L+ + K + + + +L++++ IF +Q
Sbjct: 422 ALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGF 481
Query: 524 MKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKE 583
LA K RP+Q V P PE+ L TS P+ ++ +
Sbjct: 482 RNLADKHVRPIQFVVPTPEN---------------------LVTSGTPFFSSKQGKKTWR 520
Query: 584 DDETKFEVKSEEIFESHHERG-NPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSII 642
+++ +++ + G + L+ L L + ++ +L++TE +Y++E+ +++
Sbjct: 521 QNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVL--KNHVLNELIQTERVYVRELYTVL 578
Query: 643 DGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCF 702
GY MD + L+P +L+N KD LFGN+ E+YEFHN FL LE CA PE + CF
Sbjct: 579 LGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCF 638
Query: 703 LKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKY 762
L+RK+D Q+Y KY +N PR+ IW++ +CA+F CQR+L H L L YL P QR+ KY
Sbjct: 639 LERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKY 698
Query: 763 QMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELA 822
Q+LLK LL K +KD S L++AL + DL+KS +
Sbjct: 699 QLLLKELL-----------------------KYSKDCEGSALLKKALDAMLDLLKSVNDS 735
Query: 823 VDLAAVTECPDDIGKLGKLLLHGPFSVWTIH-KDRYKMKDLIRFKPSQRQIYLFERGIVF 881
+ A+ ++ +LGK+++ G FSVW H K KMKDL RFKP QR ++L+E+ IVF
Sbjct: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
Query: 882 CKIRMEPGD-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKE 940
CK R+E G+ P YSFK K+ + I + +G +RKFEI E YI+QA++ +
Sbjct: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVD 855
Query: 941 IRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSK 974
++ W EI +L++QQ + + Q + T +
Sbjct: 856 VKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 889
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 562 bits (1448), Expect = e-160
Identities = 323/866 (37%), Positives = 494/866 (57%), Gaps = 52/866 (6%)
Query: 115 KASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHG 174
K R A +FPGNL L+ +LRP+ F+QRTFTDIG + + +F K+P++M++SVSDL
Sbjct: 10 KMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLT 69
Query: 175 YIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSML 234
YID QLT ELGGTL+Y H +W+ R AIENFALT+K AQMLQ+FG+ LA ELP +
Sbjct: 70 YIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIP 129
Query: 235 STEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATK-CPNSKLNLNQL--ENVTTM 291
S E++L + L++++ + K+G LL+ ++ P T+ +S+L ++ + T+
Sbjct: 130 SIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTI 189
Query: 292 ERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGD 351
+LL Q+ + E AF FW +H LK+ Q LQL FE DF + ++ LL +QAE +
Sbjct: 190 NKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG 249
Query: 352 SVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDD 411
++ V+Q +K+ + L+E SQE L KAQ + L G +L +HHYA D I RC ELR+L D
Sbjct: 250 TIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDI 309
Query: 412 FINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATF 471
+N K K L ++ + H+ L + Q C+ G LLA+Q +DK QS+E AL DI F
Sbjct: 310 LVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENF 369
Query: 472 LGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQT 531
L + P+ EF+++L+ + K + + + +L++++ IF +Q LA K
Sbjct: 370 LEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHV 429
Query: 532 RPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEV 591
RP+Q V P PE+ L TS P+ ++ + +++ ++
Sbjct: 430 RPIQFVVPTPEN---------------------LVTSGTPFFSSKQGKKTWRQNQSNLKI 468
Query: 592 KSEEIFESHHERG-NPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMD 650
+ + G + L+ L L + ++ +L++TE +Y++E+ +++ GY MD
Sbjct: 469 EVVPDCQEKRSSGPSSSLDNGNSLDVL--KNHVLNELIQTERVYVRELYTVLLGYRAEMD 526
Query: 651 FIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQ 710
+ L+P +L+N KD LFGN+ E+YEFHN FL LE CA PE + CFL+RK+D Q
Sbjct: 527 NPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQ 586
Query: 711 IYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLL 770
+Y KY +N PR+ IW++ +CA+F CQR+L H L L YL P QR+ KYQ+LLK LL
Sbjct: 587 MYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELL 646
Query: 771 DFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTE 830
K +KD S L++AL + DL+KS ++ A+
Sbjct: 647 -----------------------KYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAING 683
Query: 831 CPDDIGKLGKLLLHGPFSVWTIH-KDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPG 889
++ +LGK+++ G FSVW H K KMKDL RFKP QR ++L+E+ IVFCK R+E G
Sbjct: 684 YIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESG 743
Query: 890 D-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSE 948
+ P YSFK K+ + I + +G +RKFEI E YI+QA++ +++ W E
Sbjct: 744 EGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKE 803
Query: 949 ISKLLMEQQNNIKDQGNPQFEMSTSK 974
I +L++QQ + + Q + T +
Sbjct: 804 IRNILLKQQELLTVKKRKQQDQLTER 829
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 181 bits (460), Expect = 3e-45
Identities = 179/682 (26%), Positives = 292/682 (42%), Gaps = 97/682 (14%)
Query: 36 LMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEA 95
+ A++++ L + A LSGGR + G PI+TFP S I ED +++YL IPS E
Sbjct: 60 MKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEV 119
Query: 96 ASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRN 155
GF V++D R KW S+K L + +FP + + I++P F Q+ T+ G +
Sbjct: 120 CKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKF-- 177
Query: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215
EF+T + S+ L +D SQLT E G LEY H +W+ R A E++
Sbjct: 178 EFETNMV-----SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLS 232
Query: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK-LQDELKLLGKQGTTLLSCIQE---- 270
L+ LA ELP+ + +++ H++ + K ++ ++ L +G LL IQ
Sbjct: 233 RLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESF 292
Query: 271 PATKCPNSKLNL-NQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDF 329
P + +L N L V+TM L +L T + W LKL+QC QL+ FE D
Sbjct: 293 PKKNSGSGNADLQNLLPKVSTM---LDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQD- 348
Query: 330 CKAKLALDNLLEEQA----EFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGD 385
A+ D + + +T IG S H ++ +H + V +
Sbjct: 349 --AEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVAN 406
Query: 386 QLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDK----VSQWCE 441
+L++S HYA+ IR +L F ++ +L S FH++ +K V WC+
Sbjct: 407 RLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCK 466
Query: 442 A-GIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLL------ 494
A G L S+ D L D + E+ L+ E + + LL
Sbjct: 467 ACGEVDLPSELQD-----------LEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRP 515
Query: 495 -------TLDAKAKAQKVLQR-LDDVQEIFH----------KRQVSL---MKLAAKQTRP 533
+L A A K + LD + E+ H R+V L ++L Q +
Sbjct: 516 LTPGSSDSLTASANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQ-QD 574
Query: 534 VQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKF---- 589
VQ V E+ + SK + S+ AR L+ E + E N+ D +
Sbjct: 575 VQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQL 634
Query: 590 ----EVKSEEIFESHHERGNPELEQQARLGDLSPR---RRIIRDLLETEEIYIKEIKSII 642
E EEI+++ H + + R+ D R R+I+ D+ + ++KE+
Sbjct: 635 AQTGECDPEEIYQAAH-------QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKEL---- 683
Query: 643 DGYITPMDFIWLKHLIPDVLQN 664
+ WL+ L ++L +
Sbjct: 684 --------WTWLEELQKELLDD 697
Score = 151 bits (381), Expect = 4e-36
Identities = 108/377 (28%), Positives = 188/377 (49%), Gaps = 43/377 (11%)
Query: 610 QQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFL 669
++ + L R ++++L+ETE Y++++ +++GY+ M + +PD ++ +
Sbjct: 1960 EERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMK----EDGVPDDMKGKDKIV 2015
Query: 670 FGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQEC 729
FGNI ++Y++H FL ELEKC E+PE L F+K + L +Y Y +N P++ I E
Sbjct: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
Query: 730 QDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSA 789
D +F +++L H L L L P QR++KYQ+LLK L +
Sbjct: 2076 ID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSK--------------- 2119
Query: 790 KDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSV 849
K S ++EL++A+ V+ + + C +++ + I GKLLL F V
Sbjct: 2120 -------KASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV 2172
Query: 850 WTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGD--QGLS-PHYSFKKTMKLM 906
+D + + +R+I+LFE+ ++F EP D +G S P + FK ++K+
Sbjct: 2173 --TDQDAGLLP-----RCRERRIFLFEQIVIF----SEPLDKKKGFSMPGFLFKNSIKVS 2221
Query: 907 TLSIRQLGRGSHRKFEIASRNG--LEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQG 964
L + + KF + SR G +E +IL ++S +R W EI+++L Q+N +
Sbjct: 2222 CLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNALT 2281
Query: 965 NPQFEMSTSKGSGAGSG 981
+P G G G G
Sbjct: 2282 SPIEYQRNHSGGGGGGG 2298
Score = 127 bits (319), Expect = 6e-29
Identities = 117/419 (27%), Positives = 189/419 (45%), Gaps = 64/419 (15%)
Query: 607 ELEQQARLGDLSPRRR--IIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQN 664
EL ++ R S RR+ I+ +L++TE+ Y+++++ +D Y+ M + IP + N
Sbjct: 1281 ELNEEKRK---SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE--IPPGIVN 1335
Query: 665 NKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARA 724
+ +FGN++E+YEFHN FLKELEK + PE + HCF+ + Q+Y Y KN P +
Sbjct: 1336 KELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQ 1395
Query: 725 IWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGE 784
+ E +YF Q++ + YL P QR+ KYQ+LLK LL + G+
Sbjct: 1396 LILE-HAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC-------CEEGK 1447
Query: 785 LGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLH 844
G KDG L V+ + K A+ L+ + ++I G+L+L
Sbjct: 1448 --GEIKDG----------------LEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQ 1489
Query: 845 GPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMK 904
F VW K LIR K +R ++LFE +VF K E D Y +K +
Sbjct: 1490 ESFQVW-------DPKTLIR-KGRERHLFLFEMSLVFSK---EVKDSSGRSKYLYKSKLF 1538
Query: 905 LMTLSIRQLGRGSHRKFEI---ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
L + + G KF + + K +L+A+S E + W I +++ E+ ++K
Sbjct: 1539 TSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLK 1598
Query: 962 -----------------DQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGG 1003
+G E S+G G+ I R + + D +GG
Sbjct: 1599 GALKEPIHIPKTAPATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGG 1657
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/170 (23%), Positives = 77/170 (45%), Gaps = 12/170 (7%)
Query: 239 LLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQL 298
++ H Q++ L + L + + P ++ E ++ +L +L
Sbjct: 1059 MISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQ--QVKNILNEL 1116
Query: 299 DETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF-----TGIGDSV 353
+ E H+W+ +L+QC Q FE AK AL+ + + EF T G S+
Sbjct: 1117 FQRENRVLHYWTMRKRRLDQCQQYVVFERS---AKQALE-WIHDNGEFYLSTHTSTGSSI 1172
Query: 354 MHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCV 403
H +++LKEH++ + +++ E+ +LL + D + H A I+ +CV
Sbjct: 1173 QHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIK-KCV 1221
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/226 (19%), Positives = 93/226 (41%), Gaps = 15/226 (6%)
Query: 228 ELPRSM--LSTEDLLMSHTRQRDKLQDELKLLG------KQGTTLLSCIQEPATKCPNSK 279
EL + M TEDL ++ R + L + QG LL + E
Sbjct: 808 ELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELL 867
Query: 280 LNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNL 339
+ ++ T ++ LL L E ++ +H L QC+QL+H + + K L +
Sbjct: 868 CD-RDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQ---AEVKQVLGWI 923
Query: 340 LEEQAEFTG---IGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAAD 396
++ S+ EQ+ +EH++ + ++ + A + + ++Q++HY D
Sbjct: 924 RNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMD 983
Query: 397 AIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEA 442
IR ++ + + + ++ S+ F++ ++V E+
Sbjct: 984 MIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLES 1029
Score = 37.7 bits (86), Expect = 0.061
Identities = 46/210 (21%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 232 SMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTM 291
S+ + +DL+ +Q+ + K+G L+ +++ A + N ++ +
Sbjct: 702 SVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHN----SSINHI 757
Query: 292 ERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGD 351
E +L QLDE + + E +KL LQL+ FE D L++ +E ++ D
Sbjct: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
Query: 352 SVMHVEQILKEHKKLEEKSQEPLEKAQLLALV---GDQLIQSHHYAADAIRPRCVELRHL 408
+ E + ++L+ + + L L V G L+Q + ++ VEL L
Sbjct: 818 T----EDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQ----YVNEVQASGVEL--L 867
Query: 409 CDDFINGNKKKWDILGKSLEFHRQLDKVSQ 438
CD ++ + D+L E ++LD ++
Sbjct: 868 CDRDVDMATRVQDLLEFLHEKQQELDLAAE 897
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 170 bits (430), Expect = 8e-42
Identities = 120/419 (28%), Positives = 191/419 (45%), Gaps = 25/419 (5%)
Query: 36 LMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEA 95
L A +++ L + A +SGGR + G PI+TFP S I ED ++TYL S+PS +
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 96 ASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRN 155
GF V+ID R KW +K L + AFP + + I++P F Q+ T+ G +
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFG----SS 145
Query: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215
+F + ++ V ++ L +D SQLT E G+L+Y H +W+ R ++E F +
Sbjct: 146 KFIFETSMVSVEGLTKL---VDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK-LQDELKLLGKQGTTLLSCIQ----E 270
L+ LA E P + + L+ HT+ + K L+ ++ L ++G LL CI+
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
Query: 271 PATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFC 330
C + L V + LL +L T + W LKL+QC QL+ FE D
Sbjct: 263 SGRNCIPGSADFQSL--VPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQD-- 318
Query: 331 KAKLALDNLLEEQAEF----TGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQ 386
A+ D + + F T IG S + + +H S + V +
Sbjct: 319 -AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASR 377
Query: 387 LIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQ----LDKVSQWCE 441
L ++ HYA+ I+ +L F ++ IL S FH++ L V WC+
Sbjct: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCK 436
Score = 145 bits (366), Expect = 2e-34
Identities = 105/415 (25%), Positives = 205/415 (49%), Gaps = 42/415 (10%)
Query: 554 QPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKS--EEIFESHHERGNPELEQQ 611
Q ST VP A L + E + +L+ G + + E NPE EQ+
Sbjct: 1864 QASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQK 1923
Query: 612 ARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFG 671
A+ L R ++ +L++TE+ Y+K++ +++G++ ++ + +P+ ++ +FG
Sbjct: 1924 AKA--LRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIE----EKGVPEDMRGKDKIVFG 1977
Query: 672 NIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQD 731
NI ++Y++H FL ELEKC + + LA F+K + L IY Y +N PR+ I E
Sbjct: 1978 NIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD- 2036
Query: 732 CAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKD 791
AYF +++++ L L +L P QR+ KYQ+LLK L + +E
Sbjct: 2037 -AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLE------------ 2083
Query: 792 GPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWT 851
+++++A+ ++ + K C ++L + + GKLL F V
Sbjct: 2084 ----------CSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYV-- 2131
Query: 852 IHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIR 911
++ ++ + +R+++LFE+ ++F ++ + L+P Y FK+++K+ L +
Sbjct: 2132 -----IELDAGMQSRTKERRVFLFEQIVIFSELLRK---GSLTPGYMFKRSIKMNYLVLE 2183
Query: 912 QLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNP 966
+ KF + +R E+ +LQAA+ +I+ W +I+++L Q++ + +P
Sbjct: 2184 ENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSP 2238
Score = 127 bits (318), Expect = 8e-29
Identities = 127/472 (26%), Positives = 203/472 (43%), Gaps = 83/472 (17%)
Query: 558 SVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDL 617
S+ A + T + E ++ D E K + E+ N E + AR +
Sbjct: 1233 SLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEV--------NEEKRKSARKKEF 1284
Query: 618 SPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELY 677
I+ +LL+TE+ Y++++ ++ Y+ M ++ + P +L N + +FGNI+E+Y
Sbjct: 1285 -----IMAELLQTEKAYVRDLHECLETYLWEMTS-GVEEIPPGIL-NKEHIIFGNIQEIY 1337
Query: 678 EFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGV 737
+FHN FLKELEK + PE + HCF+ + Q+Y Y KN P + + E + +
Sbjct: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
Query: 738 CQRQLDHNL--PLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKR 795
QR H L + YL P QR+ KYQ+LLK LL E GEL KDG
Sbjct: 1398 QQR---HGLANSISSYLIKPVQRITKYQLLLKELLTC-----CEEGKGEL----KDG--- 1442
Query: 796 TKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKD 855
L V+ + K A+ ++ + +++ G+L+L F VW
Sbjct: 1443 -------------LEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVW----- 1484
Query: 856 RYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGR 915
K LIR K +R ++LFE +VF K E D Y +K + L + +
Sbjct: 1485 --DPKSLIR-KGRERHLFLFEISLVFSK---EIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 916 GSHRKFEIAS---RNGLEKYILQAASKEIRDCWFSEISKLLME----------------- 955
G KF + S + K +L+A++ E + W I +++ E
Sbjct: 1539 GDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK 1598
Query: 956 ----QQNNIKDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGG 1003
Q+NN K G E S+G G+ I R + + D +GG
Sbjct: 1599 TPAKQRNNSKRDG---VEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGG 1647
Score = 58.9 bits (141), Expect = 3e-08
Identities = 95/441 (21%), Positives = 170/441 (38%), Gaps = 70/441 (15%)
Query: 143 RTFTDIGIKY-YRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRH-------- 193
++ T+IG+ Y Y + +T+ +NS ++ Y++ +++ E H
Sbjct: 335 QSHTEIGVSYQYALDLQTQHNHFAMNS---MNAYVNINRIMSVASRLSEAGHYASQQIKQ 391
Query: 194 ------GQWVNHRTAIENFALTLKTTA---QMLQTFGS-----CLATAE--LPRSMLSTE 237
+W + A++ + L +A Q + F S C +E LP M E
Sbjct: 392 ISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLE 451
Query: 238 DLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVT-TMERLLV 296
+ H +++ + + G LL +Q P + P + +L N + + ++L
Sbjct: 452 LAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLS--PGNSESLTATANYSKAVHQVLD 509
Query: 297 QLDET---EKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEE-QAEFTGIGDS 352
+ E ++ W ++L+Q LQL F+ D + ++N E ++ TG+G S
Sbjct: 510 VVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKS 569
Query: 353 VMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDF 412
+ + K H EE +Q A L +QL Q+ + I L DF
Sbjct: 570 LHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDF 629
Query: 413 INGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATF- 471
+ +++ +L S+ FH ++ W E L D C + VD I F
Sbjct: 630 VRRVEQRKLLLDMSVSFHTHTKELWTWMED---LQKEMLEDVC--ADSVDAVQELIKQFQ 684
Query: 472 ----------LGTVKEYPLL------SPKEFYNEFELLLTLDAKAKA---------QKVL 506
L +KE L +P E + + K + VL
Sbjct: 685 QQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVL 744
Query: 507 QRLDDVQ----EIFHKRQVSL 523
Q+LDD Q E+FH+R++ L
Sbjct: 745 QQLDDAQVQMEELFHERKIKL 765
Score = 56.2 bits (134), Expect = 2e-07
Identities = 49/205 (23%), Positives = 89/205 (43%), Gaps = 15/205 (7%)
Query: 239 LLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQL 298
L+ H Q++ L + L I P+ + E ++ +L +L
Sbjct: 1051 LISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQ--QVKAILSEL 1108
Query: 299 DETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF-----TGIGDSV 353
+ E HFW+ +L+QC Q FE AK ALD ++E EF T G++
Sbjct: 1109 LQRENRVLHFWTLKKRRLDQCQQYVVFER---SAKQALD-WIQETGEFYLSTHTSTGETT 1164
Query: 354 MHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVEL-RHLCDDF 412
+++LKE+ + +++ EK +LL + D ++ H A IR + +H D
Sbjct: 1165 EETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFS 1224
Query: 413 INGNKKKWDI---LGKSLEFHRQLD 434
+ K ++ + LG + E ++ L+
Sbjct: 1225 LRMGKYRYSLEKALGVNTEDNKDLE 1249
Score = 38.9 bits (89), Expect = 0.027
Identities = 49/191 (25%), Positives = 81/191 (42%), Gaps = 29/191 (15%)
Query: 235 STEDL------LMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNL---NQL 285
+TEDL L HT ++ + + + +QG L I T+ S + L +
Sbjct: 800 NTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYI----TEVQASGIELICEKDI 855
Query: 286 ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAE 345
+ ++ LL L E + + H +L QCLQL+H + + K L + ++
Sbjct: 856 DLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQ---AEVKQVLGWIRNGESM 912
Query: 346 FTGI---GDSVMHVEQILKEHKKLEEKSQE-----PLEKAQLLALVGDQ----LIQSHHY 393
S+ EQ+ +EH++ + + L+K AL Q L+Q+ HY
Sbjct: 913 LNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY 972
Query: 394 AADAIRPRCVE 404
ADAIR C E
Sbjct: 973 DADAIR-ECAE 982
Score = 31.2 bits (69), Expect = 5.7
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 17/146 (11%)
Query: 232 SMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQ-------EPATKCPNSKLNLNQ 284
S+ + ++L+ +Q+ D + K+G L+ ++ EP+ + +S ++ N+
Sbjct: 672 SVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPS-EARDSAVSNNK 730
Query: 285 L---ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALD---- 337
+++ +E +L QLD+ + + E +KL+ LQL+ FE + LD
Sbjct: 731 TPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNE 790
Query: 338 NLLEEQAEFTGIGDSVMHVEQILKEH 363
+LL + +F + + EQ L+ H
Sbjct: 791 DLLRQMNDFN--TEDLTLAEQRLQRH 814
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 170 bits (430), Expect = 8e-42
Identities = 120/419 (28%), Positives = 191/419 (45%), Gaps = 25/419 (5%)
Query: 36 LMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEA 95
L A +++ L + A +SGGR + G PI+TFP S I ED ++TYL S+PS +
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 96 ASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRN 155
GF V+ID R KW +K L + AFP + + I++P F Q+ T+ G +
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFG----SS 145
Query: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215
+F + ++ V ++ L +D SQLT E G+L+Y H +W+ R ++E F +
Sbjct: 146 KFIFETSMVSVEGLTKL---VDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK-LQDELKLLGKQGTTLLSCIQ----E 270
L+ LA E P + + L+ HT+ + K L+ ++ L ++G LL CI+
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
Query: 271 PATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFC 330
C + L V + LL +L T + W LKL+QC QL+ FE D
Sbjct: 263 SGRNCIPGSADFQSL--VPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQD-- 318
Query: 331 KAKLALDNLLEEQAEF----TGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQ 386
A+ D + + F T IG S + + +H S + V +
Sbjct: 319 -AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASR 377
Query: 387 LIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQ----LDKVSQWCE 441
L ++ HYA+ I+ +L F ++ IL S FH++ L V WC+
Sbjct: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCK 436
Score = 125 bits (314), Expect = 2e-28
Identities = 114/409 (27%), Positives = 187/409 (45%), Gaps = 59/409 (14%)
Query: 558 SVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDL 617
S+ A + T + E ++ D E K + E+ N E + AR +
Sbjct: 1233 SLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEV--------NEEKRKSARKKEF 1284
Query: 618 SPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELY 677
I+ +LL+TE+ Y++++ ++ Y+ M ++ + P +L N + +FGNI+E+Y
Sbjct: 1285 -----IMAELLQTEKAYVRDLHECLETYLWEMTS-GVEEIPPGIL-NKEHIIFGNIQEIY 1337
Query: 678 EFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGV 737
+FHN FLKELEK + PE + HCF+ + Q+Y Y KN P + + E + +
Sbjct: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
Query: 738 CQRQLDHNL--PLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKR 795
QR H L + YL P QR+ KYQ+LLK LL E GEL KDG
Sbjct: 1398 QQR---HGLANSISSYLIKPVQRITKYQLLLKELLTC-----CEEGKGEL----KDG--- 1442
Query: 796 TKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKD 855
L V+ + K A+ ++ + +++ G+L+L F VW
Sbjct: 1443 -------------LEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVW----- 1484
Query: 856 RYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGR 915
K LIR K +R ++LFE +VF K E D Y +K + L + +
Sbjct: 1485 --DPKSLIR-KGRERHLFLFEISLVFSK---EIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 916 GSHRKFEIAS---RNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
G KF + S + K +L+A++ E + W I +++ E+ ++K
Sbjct: 1539 GDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLK 1587
Score = 58.9 bits (141), Expect = 3e-08
Identities = 95/441 (21%), Positives = 170/441 (38%), Gaps = 70/441 (15%)
Query: 143 RTFTDIGIKY-YRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRH-------- 193
++ T+IG+ Y Y + +T+ +NS ++ Y++ +++ E H
Sbjct: 335 QSHTEIGVSYQYALDLQTQHNHFAMNS---MNAYVNINRIMSVASRLSEAGHYASQQIKQ 391
Query: 194 ------GQWVNHRTAIENFALTLKTTA---QMLQTFGS-----CLATAE--LPRSMLSTE 237
+W + A++ + L +A Q + F S C +E LP M E
Sbjct: 392 ISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLE 451
Query: 238 DLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVT-TMERLLV 296
+ H +++ + + G LL +Q P + P + +L N + + ++L
Sbjct: 452 LAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLS--PGNSESLTATANYSKAVHQVLD 509
Query: 297 QLDET---EKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEE-QAEFTGIGDS 352
+ E ++ W ++L+Q LQL F+ D + ++N E ++ TG+G S
Sbjct: 510 VVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKS 569
Query: 353 VMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDF 412
+ + K H EE +Q A L +QL Q+ + I L DF
Sbjct: 570 LHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDF 629
Query: 413 INGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATF- 471
+ +++ +L S+ FH ++ W E L D C + VD I F
Sbjct: 630 VRRVEQRKLLLDMSVSFHTHTKELWTWMED---LQKEMLEDVC--ADSVDAVQELIKQFQ 684
Query: 472 ----------LGTVKEYPLL------SPKEFYNEFELLLTLDAKAKA---------QKVL 506
L +KE L +P E + + K + VL
Sbjct: 685 QQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVL 744
Query: 507 QRLDDVQ----EIFHKRQVSL 523
Q+LDD Q E+FH+R++ L
Sbjct: 745 QQLDDAQVQMEELFHERKIKL 765
Score = 56.2 bits (134), Expect = 2e-07
Identities = 49/205 (23%), Positives = 89/205 (43%), Gaps = 15/205 (7%)
Query: 239 LLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQL 298
L+ H Q++ L + L I P+ + E ++ +L +L
Sbjct: 1051 LISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQ--QVKAILSEL 1108
Query: 299 DETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF-----TGIGDSV 353
+ E HFW+ +L+QC Q FE AK ALD ++E EF T G++
Sbjct: 1109 LQRENRVLHFWTLKKRRLDQCQQYVVFER---SAKQALD-WIQETGEFYLSTHTSTGETT 1164
Query: 354 MHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVEL-RHLCDDF 412
+++LKE+ + +++ EK +LL + D ++ H A IR + +H D
Sbjct: 1165 EETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFS 1224
Query: 413 INGNKKKWDI---LGKSLEFHRQLD 434
+ K ++ + LG + E ++ L+
Sbjct: 1225 LRMGKYRYSLEKALGVNTEDNKDLE 1249
Score = 38.9 bits (89), Expect = 0.027
Identities = 49/191 (25%), Positives = 81/191 (42%), Gaps = 29/191 (15%)
Query: 235 STEDL------LMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNL---NQL 285
+TEDL L HT ++ + + + +QG L I T+ S + L +
Sbjct: 800 NTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYI----TEVQASGIELICEKDI 855
Query: 286 ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAE 345
+ ++ LL L E + + H +L QCLQL+H + + K L + ++
Sbjct: 856 DLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQ---AEVKQVLGWIRNGESM 912
Query: 346 FTGI---GDSVMHVEQILKEHKKLEEKSQE-----PLEKAQLLALVGDQ----LIQSHHY 393
S+ EQ+ +EH++ + + L+K AL Q L+Q+ HY
Sbjct: 913 LNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHY 972
Query: 394 AADAIRPRCVE 404
ADAIR C E
Sbjct: 973 DADAIR-ECAE 982
Score = 31.2 bits (69), Expect = 5.7
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 17/146 (11%)
Query: 232 SMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQ-------EPATKCPNSKLNLNQ 284
S+ + ++L+ +Q+ D + K+G L+ ++ EP+ + +S ++ N+
Sbjct: 672 SVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPS-EARDSAVSNNK 730
Query: 285 L---ENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALD---- 337
+++ +E +L QLD+ + + E +KL+ LQL+ FE + LD
Sbjct: 731 TPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNE 790
Query: 338 NLLEEQAEFTGIGDSVMHVEQILKEH 363
+LL + +F + + EQ L+ H
Sbjct: 791 DLLRQMNDFN--TEDLTLAEQRLQRH 814
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 156 bits (395), Expect = 9e-38
Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%)
Query: 606 PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665
PE E++ + L ++ +L+ETE++Y+ ++ I++GY+ M +P+ L+
Sbjct: 147 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 202
Query: 666 KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725
+FGNI+++YE+H FL+EL++C ++P+ LA F+K + L +Y Y +N P++ +
Sbjct: 203 DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 262
Query: 726 WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785
E D +YF ++QL H L L L P QR++KYQ+LLK L + + M+
Sbjct: 263 VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 315
Query: 786 GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845
+ +L+QA+ V+ + K C + L + + GKLL G
Sbjct: 316 ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 357
Query: 846 PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905
+ W + L+ + +R+++LFE+ I+F + G P Y +K ++K+
Sbjct: 358 QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 414
Query: 906 MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962
L + +G +F + SR G+++Y+LQAA I W ++++L Q++ +
Sbjct: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474
Query: 963 QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006
+P Q S + G GP + + R + S+ I G
Sbjct: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 521
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 156 bits (395), Expect = 9e-38
Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%)
Query: 606 PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665
PE E++ + L ++ +L+ETE++Y+ ++ I++GY+ M +P+ L+
Sbjct: 186 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 241
Query: 666 KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725
+FGNI+++YE+H FL+EL++C ++P+ LA F+K + L +Y Y +N P++ +
Sbjct: 242 DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 301
Query: 726 WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785
E D +YF ++QL H L L L P QR++KYQ+LLK L + + M+
Sbjct: 302 VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 354
Query: 786 GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845
+ +L+QA+ V+ + K C + L + + GKLL G
Sbjct: 355 ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 396
Query: 846 PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905
+ W + L+ + +R+++LFE+ I+F + G P Y +K ++K+
Sbjct: 397 QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 453
Query: 906 MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962
L + +G +F + SR G+++Y+LQAA I W ++++L Q++ +
Sbjct: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
Query: 963 QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006
+P Q S + G GP + + R + S+ I G
Sbjct: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 560
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 145 bits (366), Expect = 2e-34
Identities = 105/415 (25%), Positives = 205/415 (49%), Gaps = 42/415 (10%)
Query: 554 QPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKS--EEIFESHHERGNPELEQQ 611
Q ST VP A L + E + +L+ G + + E NPE EQ+
Sbjct: 167 QASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQK 226
Query: 612 ARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFG 671
A+ L R ++ +L++TE+ Y+K++ +++G++ ++ + +P+ ++ +FG
Sbjct: 227 AKA--LRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIE----EKGVPEDMRGKDKIVFG 280
Query: 672 NIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQD 731
NI ++Y++H FL ELEKC + + LA F+K + L IY Y +N PR+ I E
Sbjct: 281 NIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD- 339
Query: 732 CAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKD 791
AYF +++++ L L +L P QR+ KYQ+LLK L + +E
Sbjct: 340 -AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLE------------ 386
Query: 792 GPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWT 851
+++++A+ ++ + K C ++L + + GKLL F V
Sbjct: 387 ----------CSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYV-- 434
Query: 852 IHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIR 911
++ ++ + +R+++LFE+ ++F ++ + L+P Y FK+++K+ L +
Sbjct: 435 -----IELDAGMQSRTKERRVFLFEQIVIFSELLRK---GSLTPGYMFKRSIKMNYLVLE 486
Query: 912 QLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNP 966
+ KF + +R E+ +LQAA+ +I+ W +I+++L Q++ + +P
Sbjct: 487 ENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSP 541
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 128 bits (321), Expect = 3e-29
Identities = 212/964 (21%), Positives = 372/964 (38%), Gaps = 160/964 (16%)
Query: 43 EQLHRQFAILSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSIPSVEAASIG 99
E L A L G R G ++ S ++ + ++ YL SIP E ++G
Sbjct: 188 ELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALG 247
Query: 100 FIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFK 158
V++D R SS+ + L+++ A PG + + ++ + E
Sbjct: 248 LTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLL--------------KEVP 293
Query: 159 TKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ 218
+ + + + S S L +I + L LGG L Y H W++ R +E + +LQ
Sbjct: 294 SGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
Query: 219 TFGSCLATAELPRSM--------LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE 270
G+ + +P+ M L ++LM L L+ G + T L
Sbjct: 353 --GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLA-WLQCQGGRELTWLKQEVP 409
Query: 271 PATKCPNSKLNLNQ-----------LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQC 319
T P+ + +++ L +T +Q E + S H ++
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLH-QIEVW 468
Query: 320 LQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQL 379
LQ + + +LD LL+ Q F + Q+ +E + EK +PL +
Sbjct: 469 LQQVGWPALEEAGEPSLDMLLQAQGSF-------QELYQVAQEQVRQGEKFLQPLTGWEA 521
Query: 380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQW 439
L D R + LR +F ++ L + + + W
Sbjct: 522 AEL-------------DPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTW 568
Query: 440 CEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAK 499
E G +LA Q R GV + + +P L P F + L L ++
Sbjct: 569 AEEGQRVLAELE----QERPGVVLQQLQLHW-----TRHPDLPPAHFRKMWALATGLGSE 619
Query: 500 AKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSV 559
A Q+ Q+ + LA Q P S+ S+ +
Sbjct: 620 AIRQECRWAWARCQDTW---------LALDQKLEASLKLPPVGSTASLCVSQVP----AA 666
Query: 560 PLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHH----------ERGNPELE 609
P PLR + D + SE HH E G L
Sbjct: 667 PAHPPLR-------------KAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALP 713
Query: 610 QQARL----GDLSPR-----RRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Q + G PR + ++ +++ TE Y++ ++ ++ Y +D + +P
Sbjct: 714 QASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD----RPDVPQ 769
Query: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
L+ + LFGN+ +L +FH FL+ELE C +P +A+ FL+ + +Y Y KN P
Sbjct: 770 GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKP 829
Query: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
R+ A+ +F Q+ L +L L YL P QR+ KY +LL+ L
Sbjct: 830 RSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQEL----------- 877
Query: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
A GP + + L++A +++ ++ + + A+ C ++ + G+
Sbjct: 878 ------ARACGGPTQELSA-----LREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQ 926
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
L+ F V T R+K S R+I+LFE ++F K R G G+ +++K
Sbjct: 927 LVRQDEFVVRT---GRHK---------SVRRIFLFEELLLFSKPR--HGPTGVDT-FAYK 971
Query: 901 KTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN 958
++ K+ L + + S+ +FEI R + ++LQA+S I+ W ++IS LL Q
Sbjct: 972 RSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
Query: 959 NIKD 962
+ K+
Sbjct: 1032 HNKE 1035
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 128 bits (321), Expect = 3e-29
Identities = 212/964 (21%), Positives = 372/964 (38%), Gaps = 160/964 (16%)
Query: 43 EQLHRQFAILSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSIPSVEAASIG 99
E L A L G R G ++ S ++ + ++ YL SIP E ++G
Sbjct: 188 ELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALG 247
Query: 100 FIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFK 158
V++D R SS+ + L+++ A PG + + ++ + E
Sbjct: 248 LTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLL--------------KEVP 293
Query: 159 TKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ 218
+ + + + S S L +I + L LGG L Y H W++ R +E + +LQ
Sbjct: 294 SGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
Query: 219 TFGSCLATAELPRSM--------LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE 270
G+ + +P+ M L ++LM L L+ G + T L
Sbjct: 353 --GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLA-WLQCQGGRELTWLKQEVP 409
Query: 271 PATKCPNSKLNLNQ-----------LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQC 319
T P+ + +++ L +T +Q E + S H ++
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLH-QIEVW 468
Query: 320 LQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQL 379
LQ + + +LD LL+ Q F + Q+ +E + EK +PL +
Sbjct: 469 LQQVGWPALEEAGEPSLDMLLQAQGSF-------QELYQVAQEQVRQGEKFLQPLTGWEA 521
Query: 380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQW 439
L D R + LR +F ++ L + + + W
Sbjct: 522 AEL-------------DPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTW 568
Query: 440 CEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAK 499
E G +LA Q R GV + + +P L P F + L L ++
Sbjct: 569 AEEGQRVLAELE----QERPGVVLQQLQLHW-----TRHPDLPPAHFRKMWALATGLGSE 619
Query: 500 AKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSV 559
A Q+ Q+ + LA Q P S+ S+ +
Sbjct: 620 AIRQECRWAWARCQDTW---------LALDQKLEASLKLPPVGSTASLCVSQVP----AA 666
Query: 560 PLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHH----------ERGNPELE 609
P PLR + D + SE HH E G L
Sbjct: 667 PAHPPLR-------------KAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALP 713
Query: 610 QQARL----GDLSPR-----RRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Q + G PR + ++ +++ TE Y++ ++ ++ Y +D + +P
Sbjct: 714 QASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD----RPDVPQ 769
Query: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
L+ + LFGN+ +L +FH FL+ELE C +P +A+ FL+ + +Y Y KN P
Sbjct: 770 GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKP 829
Query: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
R+ A+ +F Q+ L +L L YL P QR+ KY +LL+ L
Sbjct: 830 RSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQEL----------- 877
Query: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
A GP + + L++A +++ ++ + + A+ C ++ + G+
Sbjct: 878 ------ARACGGPTQELSA-----LREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQ 926
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
L+ F V T R+K S R+I+LFE ++F K R G G+ +++K
Sbjct: 927 LVRQDEFVVRT---GRHK---------SVRRIFLFEELLLFSKPR--HGPTGVDT-FAYK 971
Query: 901 KTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN 958
++ K+ L + + S+ +FEI R + ++LQA+S I+ W ++IS LL Q
Sbjct: 972 RSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
Query: 959 NIKD 962
+ K+
Sbjct: 1032 HNKE 1035
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 128 bits (321), Expect = 3e-29
Identities = 212/964 (21%), Positives = 372/964 (38%), Gaps = 160/964 (16%)
Query: 43 EQLHRQFAILSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSIPSVEAASIG 99
E L A L G R G ++ S ++ + ++ YL SIP E ++G
Sbjct: 188 ELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALG 247
Query: 100 FIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFK 158
V++D R SS+ + L+++ A PG + + ++ + E
Sbjct: 248 LTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLL--------------KEVP 293
Query: 159 TKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ 218
+ + + + S S L +I + L LGG L Y H W++ R +E + +LQ
Sbjct: 294 SGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
Query: 219 TFGSCLATAELPRSM--------LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE 270
G+ + +P+ M L ++LM L L+ G + T L
Sbjct: 353 --GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLA-WLQCQGGRELTWLKQEVP 409
Query: 271 PATKCPNSKLNLNQ-----------LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQC 319
T P+ + +++ L +T +Q E + S H ++
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLH-QIEVW 468
Query: 320 LQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQL 379
LQ + + +LD LL+ Q F + Q+ +E + EK +PL +
Sbjct: 469 LQQVGWPALEEAGEPSLDMLLQAQGSF-------QELYQVAQEQVRQGEKFLQPLTGWEA 521
Query: 380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQW 439
L D R + LR +F ++ L + + + W
Sbjct: 522 AEL-------------DPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTW 568
Query: 440 CEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAK 499
E G +LA Q R GV + + +P L P F + L L ++
Sbjct: 569 AEEGQRVLAELE----QERPGVVLQQLQLHW-----TRHPDLPPAHFRKMWALATGLGSE 619
Query: 500 AKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSV 559
A Q+ Q+ + LA Q P S+ S+ +
Sbjct: 620 AIRQECRWAWARCQDTW---------LALDQKLEASLKLPPVGSTASLCVSQVP----AA 666
Query: 560 PLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHH----------ERGNPELE 609
P PLR + D + SE HH E G L
Sbjct: 667 PAHPPLR-------------KAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALP 713
Query: 610 QQARL----GDLSPR-----RRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Q + G PR + ++ +++ TE Y++ ++ ++ Y +D + +P
Sbjct: 714 QASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD----RPDVPQ 769
Query: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
L+ + LFGN+ +L +FH FL+ELE C +P +A+ FL+ + +Y Y KN P
Sbjct: 770 GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKP 829
Query: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
R+ A+ +F Q+ L +L L YL P QR+ KY +LL+ L
Sbjct: 830 RSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQEL----------- 877
Query: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
A GP + + L++A +++ ++ + + A+ C ++ + G+
Sbjct: 878 ------ARACGGPTQELSA-----LREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQ 926
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
L+ F V T R+K S R+I+LFE ++F K R G G+ +++K
Sbjct: 927 LVRQDEFVVRT---GRHK---------SVRRIFLFEELLLFSKPR--HGPTGVDT-FAYK 971
Query: 901 KTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN 958
++ K+ L + + S+ +FEI R + ++LQA+S I+ W ++IS LL Q
Sbjct: 972 RSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
Query: 959 NIKD 962
+ K+
Sbjct: 1032 HNKE 1035
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 128 bits (321), Expect = 3e-29
Identities = 212/964 (21%), Positives = 372/964 (38%), Gaps = 160/964 (16%)
Query: 43 EQLHRQFAILSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSIPSVEAASIG 99
E L A L G R G ++ S ++ + ++ YL SIP E ++G
Sbjct: 188 ELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALG 247
Query: 100 FIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFK 158
V++D R SS+ + L+++ A PG + + ++ + E
Sbjct: 248 LTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLL--------------KEVP 293
Query: 159 TKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ 218
+ + + + S S L +I + L LGG L Y H W++ R +E + +LQ
Sbjct: 294 SGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
Query: 219 TFGSCLATAELPRSM--------LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE 270
G+ + +P+ M L ++LM L L+ G + T L
Sbjct: 353 --GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLA-WLQCQGGRELTWLKQEVP 409
Query: 271 PATKCPNSKLNLNQ-----------LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQC 319
T P+ + +++ L +T +Q E + S H ++
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLH-QIEVW 468
Query: 320 LQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQL 379
LQ + + +LD LL+ Q F + Q+ +E + EK +PL +
Sbjct: 469 LQQVGWPALEEAGEPSLDMLLQAQGSF-------QELYQVAQEQVRQGEKFLQPLTGWEA 521
Query: 380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQW 439
L D R + LR +F ++ L + + + W
Sbjct: 522 AEL-------------DPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTW 568
Query: 440 CEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAK 499
E G +LA Q R GV + + +P L P F + L L ++
Sbjct: 569 AEEGQRVLAELE----QERPGVVLQQLQLHW-----TRHPDLPPAHFRKMWALATGLGSE 619
Query: 500 AKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSV 559
A Q+ Q+ + LA Q P S+ S+ +
Sbjct: 620 AIRQECRWAWARCQDTW---------LALDQKLEASLKLPPVGSTASLCVSQVP----AA 666
Query: 560 PLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHH----------ERGNPELE 609
P PLR + D + SE HH E G L
Sbjct: 667 PAHPPLR-------------KAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALP 713
Query: 610 QQARL----GDLSPR-----RRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Q + G PR + ++ +++ TE Y++ ++ ++ Y +D + +P
Sbjct: 714 QASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD----RPDVPQ 769
Query: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
L+ + LFGN+ +L +FH FL+ELE C +P +A+ FL+ + +Y Y KN P
Sbjct: 770 GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKP 829
Query: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
R+ A+ +F Q+ L +L L YL P QR+ KY +LL+ L
Sbjct: 830 RSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQEL----------- 877
Query: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
A GP + + L++A +++ ++ + + A+ C ++ + G+
Sbjct: 878 ------ARACGGPTQELSA-----LREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQ 926
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
L+ F V T R+K S R+I+LFE ++F K R G G+ +++K
Sbjct: 927 LVRQDEFVVRT---GRHK---------SVRRIFLFEELLLFSKPR--HGPTGVDT-FAYK 971
Query: 901 KTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN 958
++ K+ L + + S+ +FEI R + ++LQA+S I+ W ++IS LL Q
Sbjct: 972 RSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
Query: 959 NIKD 962
+ K+
Sbjct: 1032 HNKE 1035
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 127 bits (320), Expect = 4e-29
Identities = 204/926 (22%), Positives = 362/926 (39%), Gaps = 157/926 (16%)
Query: 78 EDFLNVMTYLTSIPSVEAASIGFIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILR 136
++ + ++ YL SIP E ++G V++D R SS+ + L+++ A PG + + ++
Sbjct: 145 QELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG 204
Query: 137 PSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQW 196
+ E + + + + S S L +I + L LGG L Y H W
Sbjct: 205 STLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAW 249
Query: 197 VNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSM--------LSTEDLLMSHTRQRD 248
++ R +E + +LQ G+ + +P+ M L ++LM
Sbjct: 250 LDFRRRLEALLQNCQAACALLQ--GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSP 307
Query: 249 KLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQ-----------LENVTTMERLLVQ 297
L L+ G + T L T P+ + +++ L +T +Q
Sbjct: 308 WLA-WLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQ 366
Query: 298 LDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVE 357
E + S H ++ LQ + + +LD LL+ Q F +
Sbjct: 367 ALELVQTLEARESGLH-QIEVWLQQVGWPALEEAGEPSLDMLLQAQGSF-------QELY 418
Query: 358 QILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNK 417
Q+ +E + EK +PL + L D R + LR +F
Sbjct: 419 QVAQEQVRQGEKFLQPLTGWEAAEL-------------DPPGARFLALRAQLTEFSRALA 465
Query: 418 KKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKE 477
++ L + + + W E G +LA Q R GV + +
Sbjct: 466 QRCQRLADAERLFQLFREALTWAEEGQRVLAELE----QERPGVVLQQLQLHW-----TR 516
Query: 478 YPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPV 537
+P L P F + L L ++A Q+ Q+ + LA Q
Sbjct: 517 HPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTW---------LALDQKLEASLK 567
Query: 538 APHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIF 597
P S+ S+ + P PLR + D + SE
Sbjct: 568 LPPVGSTASLCVSQVP----AAPAHPPLR-------------KAYSFDRNLGQSLSEPAC 610
Query: 598 ESHH----------ERGNPELEQQARL----GDLSPR-----RRIIRDLLETEEIYIKEI 638
HH E G L Q + G PR + ++ +++ TE Y++ +
Sbjct: 611 HCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRAL 670
Query: 639 KSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELL 698
+ ++ Y +D + +P L+ + LFGN+ +L +FH FL+ELE C +P +
Sbjct: 671 EYTMENYFPELD----RPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRV 726
Query: 699 AHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQR 758
A+ FL+ + +Y Y KN PR+ A+ +F Q+ L +L L YL P QR
Sbjct: 727 AYAFLRHRVQFGMYALYSKNKPRSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQR 785
Query: 759 LIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKS 818
+ KY +LL+ L A GP + + L++A +++ ++
Sbjct: 786 MGKYALLLQEL-----------------ARACGGPTQELSA-----LREAQSLVHFQLRH 823
Query: 819 CELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERG 878
+ + A+ C ++ + G+L+ F V T R+K S R+I+LFE
Sbjct: 824 GNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRT---GRHK---------SVRRIFLFEEL 871
Query: 879 IVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQA 936
++F K R G G+ +++K++ K+ L + + S+ +FEI R + ++LQA
Sbjct: 872 LLFSKPR--HGPTGVDT-FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQA 928
Query: 937 ASKEIRDCWFSEISKLLMEQQNNIKD 962
+S I+ W ++IS LL Q + K+
Sbjct: 929 SSLAIKQAWTADISHLLWRQAVHNKE 954
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 119 bits (297), Expect = 2e-26
Identities = 124/450 (27%), Positives = 199/450 (44%), Gaps = 64/450 (14%)
Query: 527 AAKQTRPVQPVAPHPESSP-KWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDD 585
+A + P Q +A P P K + KT P + P R S +P T + S+G E
Sbjct: 701 SACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGP-RDSCQP-DHTSVFSKGLEVT 758
Query: 586 ETKFEVKSEEIFESHHERGNP----------------ELEQQARLGDLSPRRRIIRDLLE 629
T K +++ H R P E + + ++G S R I+ +++
Sbjct: 759 STVATEKKLPLWQ--HARSPPVTQSRSLSSPSGLHPAEEDGRQQVGS-SRLRHIMAEMIA 815
Query: 630 TEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELE 689
TE YI+ + +ID Y M+ + L P L+ +FGN+ +L++FH + FL+ELE
Sbjct: 816 TEREYIRCLGYVIDNYFPEMERMDL----PQGLRGKHHVIFGNLEKLHDFHQQHFLRELE 871
Query: 690 KCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLF 749
+C P + FL+ +E +Y Y KN P++ A+ A+F QR+L + L
Sbjct: 872 RCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSS-HGNAFFKDKQRELGDKMDLA 930
Query: 750 KYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQAL 809
YL P QR+ KY +LL+ LL E G L + G R + +L+
Sbjct: 931 SYLLRPVQRVAKYALLLQDLL-------KEASCG-LAQGQELGELRAAEVVVCFQLRHG- 981
Query: 810 AVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQ 869
DL LA+D A+ C ++ + G+L F V K +Y
Sbjct: 982 ---NDL-----LAMD--AIRGCDVNLKEQGQLRCRDEFIVCCGRK-KY-----------L 1019
Query: 870 RQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI---ASR 926
R ++LFE I+F K + G + Y +K++ K + + + S +FEI R
Sbjct: 1020 RHVFLFEDLILFSKTQKVEGSHDV---YLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRR 1076
Query: 927 NGLEKYILQAASKEIRDCWFSEISKLLMEQ 956
+ YILQA+S E++ W I ++L Q
Sbjct: 1077 KSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
Score = 66.6 bits (161), Expect = 1e-10
Identities = 70/300 (23%), Positives = 127/300 (42%), Gaps = 33/300 (11%)
Query: 35 PLMAVEIIEQLHRQFAI-LSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSI 90
P +++ ++L + + L G R G ++ S +H + ++ Y SI
Sbjct: 187 PKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSI 246
Query: 91 PSVEAASIGFIVVIDRRRDKWS-SVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIG 149
P E +G +V++D RR + +V +L+ + + I +L
Sbjct: 247 PRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKE---------- 296
Query: 150 IKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALT 209
+R + + +V+S+ +H ++D QLT +L G+ Y HG W+ R +E+FA
Sbjct: 297 -SAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAAN 355
Query: 210 LKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSH-TRQRDKLQDELKL-LGKQGTTLLSC 267
+ LQ L T PR+ +L+ H T + L+D L + L +G T+L+
Sbjct: 356 CEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLAR 415
Query: 268 IQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEH 327
++ +S+ + LE T+ L ++DE H L L +LQ EH
Sbjct: 416 LRREELGTEDSR---DTLEAATS---LYDRVDE---------EVHRLVLTSNNRLQQLEH 460
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 109 bits (272), Expect = 2e-23
Identities = 88/344 (25%), Positives = 165/344 (47%), Gaps = 52/344 (15%)
Query: 622 RIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHN 681
R+++++LETE Y++++KSI++ Y+ D I + +P + + LFGNI+++Y F N
Sbjct: 116 RVVQEILETERTYVQDLKSIVEDYL---DCIRDQTKLP-LGTEERSALFGNIQDIYHF-N 170
Query: 682 RTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQD----CAYFGV 737
L++LE C +P +A CF+ + E+ IY +Y N PR+ A+ EC +F
Sbjct: 171 SELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRE 230
Query: 738 CQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTK 797
Q L H+LPL YL P QR++KY +LL + E+ D + + ++ A D
Sbjct: 231 RQETLKHSLPLGSYLLKPVQRILKYHLLLH---EIENHLDKDTEGYDVVLDAID------ 281
Query: 798 DSAFSTELQQALAVIEDLIKSCELAVDLAAVTEC-----PDDIGKLGKLLLHGPFSVWTI 852
+Q+ I D+ + E AV L + D+ G+L+L G F
Sbjct: 282 ------TMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFR---- 331
Query: 853 HKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQ 912
I+ ++R ++LF++ ++ K R + +++K + L + +
Sbjct: 332 ----------IQRAKNERTLFLFDKLLLITKKRDDT--------FTYKAHILCGNLMLVE 373
Query: 913 LGRGSHRKFEIAS-RNGLEKYILQAASKEIRDCWFSEISKLLME 955
+ F + +N ++ +QA S++ + W + +L++E
Sbjct: 374 VIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILE 417
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 93.2 bits (230), Expect = 1e-18
Identities = 86/361 (23%), Positives = 164/361 (45%), Gaps = 66/361 (18%)
Query: 607 ELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHL-----IPDV 661
E E +ARL +I++LL +E+ +++E++ + + L+HL +P
Sbjct: 5687 EDEYKARLSS------VIQELLSSEQAFVEELQFLQSHH--------LQHLERCPHVPIA 5732
Query: 662 LQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPR 721
+ K +F N+R++ FH+ +FL+EL++C + + +A CF+K + + Y ++ +
Sbjct: 5733 VAGQKAVIFRNVRDIGRFHS-SFLQELQQC-DTDDDVAMCFIKNQAAFEQYLEFLVGRVQ 5790
Query: 722 ARAIWQECQDCAYFGVCQRQLDHNL-----------PLFKYLKGPSQRLIKYQMLLKGLL 770
A ++ ++ ++ + L PL YL+ P +R+ +YQ LLK L+
Sbjct: 5791 AESVVVSTAIQEFY---KKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 771 DFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTE 830
++ + ++ A L+QA AV+ L + E + ++ +
Sbjct: 5848 -------------------RNKARNRQNCAL---LEQAYAVVSALPQRAENKLHVSLMEN 5885
Query: 831 CPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGD 890
P + LG+ + G F VW + +K R ++LF +V CK R +
Sbjct: 5886 YPGTLQALGEPIRQGHFIVW-----EGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRT 5940
Query: 891 QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSE 948
+S Y F+ MKL ++ + G R FE+ + + KY+LQA + I+ W E
Sbjct: 5941 DTVS--YVFRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKE 5998
Query: 949 I 949
I
Sbjct: 5999 I 5999
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 93.2 bits (230), Expect = 1e-18
Identities = 86/361 (23%), Positives = 164/361 (45%), Gaps = 66/361 (18%)
Query: 607 ELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHL-----IPDV 661
E E +ARL +I++LL +E+ +++E++ + + L+HL +P
Sbjct: 5687 EDEYKARLSS------VIQELLSSEQAFVEELQFLQSHH--------LQHLERCPHVPIA 5732
Query: 662 LQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPR 721
+ K +F N+R++ FH+ +FL+EL++C + + +A CF+K + + Y ++ +
Sbjct: 5733 VAGQKAVIFRNVRDIGRFHS-SFLQELQQC-DTDDDVAMCFIKNQAAFEQYLEFLVGRVQ 5790
Query: 722 ARAIWQECQDCAYFGVCQRQLDHNL-----------PLFKYLKGPSQRLIKYQMLLKGLL 770
A ++ ++ ++ + L PL YL+ P +R+ +YQ LLK L+
Sbjct: 5791 AESVVVSTAIQEFY---KKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 771 DFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTE 830
++ + ++ A L+QA AV+ L + E + ++ +
Sbjct: 5848 -------------------RNKARNRQNCAL---LEQAYAVVSALPQRAENKLHVSLMEN 5885
Query: 831 CPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGD 890
P + LG+ + G F VW + +K R ++LF +V CK R +
Sbjct: 5886 YPGTLQALGEPIRQGHFIVW-----EGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRT 5940
Query: 891 QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSE 948
+S Y F+ MKL ++ + G R FE+ + + KY+LQA + I+ W E
Sbjct: 5941 DTVS--YVFRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKE 5998
Query: 949 I 949
I
Sbjct: 5999 I 5999
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 91.3 bits (225), Expect = 5e-18
Identities = 93/356 (26%), Positives = 158/356 (44%), Gaps = 54/356 (15%)
Query: 615 GDLSPRR--RIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGN 672
G P R R+ R+++ETE Y+++++SI++ Y+ P+ L + + LF N
Sbjct: 96 GSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPL----LDGGVLGLSVEQVGTLFAN 151
Query: 673 IRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQ-- 730
I ++YEF + L++LE + + +A CF++R ED IY Y N P + A+ +E
Sbjct: 152 IEDIYEFSSE-LLEDLEN-SSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS 209
Query: 731 --DCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGS 788
+ Q QL H+LPL +L P QR++KY +LL+ ELG
Sbjct: 210 PPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQ----------------ELGKH 253
Query: 789 AKDGPKRTKDSAFSTELQQALAV---IEDLIKSCELAVDLAAVTE-----CPDDIGKLGK 840
+GP + AV I D+ + E A L V ++ G+
Sbjct: 254 WAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGE 313
Query: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
L+L G F R R + +R ++LF R ++ K R GL Y++K
Sbjct: 314 LVLEGAF--------RGGGGGGPRLRGGERLLFLFSRMLLVAKRR------GL--EYTYK 357
Query: 901 KTMKLMTLSIRQLGRGSHRKFEIASRN-GLEKYILQAASKEIRDCWFSEISKLLME 955
+ LS+ + R F+++ +++LQA ++E + W + +L E
Sbjct: 358 GHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFE 412
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 86.3 bits (212), Expect = 1e-16
Identities = 96/447 (21%), Positives = 190/447 (42%), Gaps = 45/447 (10%)
Query: 41 IIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGF 100
I+ L ++ A LSGG+ I+T P + ++ + YL SIPS + + GF
Sbjct: 6 ILPILKKKLAFLSGGKDRRSGLILTIPLC--LEQTNMDELSVTLDYLLSIPSEKCKARGF 63
Query: 101 IVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTK 160
V++D R+ +W+ VK + + P + L+ +++P F + T +++ + +
Sbjct: 64 TVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTH--FCFWKEKDRLG 121
Query: 161 VPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTF 220
+I+V S + L YI+ QLT + GG+L Y H W+N R E F + L
Sbjct: 122 FEVILV-SANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALI 180
Query: 221 GSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKL 280
+ S + + LQ G LLS +Q+ + +
Sbjct: 181 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQ--------TGHELLSELQQRRFNGSDGGV 232
Query: 281 NLNQLEN-VTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNL 339
+ + +++ + +++ LD + ++ + E + ++ QL+ + + L+
Sbjct: 233 SWSPMDDELLAQPQVMKLLDSLREQYTRY-QEVCRQRSKRTQLEEIQQKVMQVVNWLEGP 291
Query: 340 LEEQAEFT-GIGDSVMHVEQILKEHKKLEEKSQEPLE-----KAQLLALV--GDQLIQSH 391
EQ GIGDS+ + + ++H+++E + E Q+ AL+ GD+
Sbjct: 292 GSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDE----- 346
Query: 392 HYAADAIRPRCV--ELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLAS 449
D + + + +L +C + + + ++L +LEFH +SQ + + +L
Sbjct: 347 ---EDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLC- 402
Query: 450 QAVDKCQSREGVDIALNDIATFLGTVK 476
VD+A D A+ T+K
Sbjct: 403 -----------VDVAPADGASIQQTLK 418
Score = 43.9 bits (102), Expect = 9e-04
Identities = 54/278 (19%), Positives = 103/278 (37%), Gaps = 6/278 (2%)
Query: 168 SVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ----MLQTFGSC 223
+ D ++ L ++L YR + R + AL AQ L
Sbjct: 342 NAGDEEDLVELKSLQQQLSDVC-YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
Query: 224 LATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLN 283
L P S + L + + L+ L ++G LL I A+ + +
Sbjct: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIE 460
Query: 284 QLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQ 343
ENV ++ ++ + ++ LK+ Q +QL E D +A L LL+
Sbjct: 461 NKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDAL 520
Query: 344 AE-FTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRC 402
+ +GD + +L++H+K + +Q + + L L QS + +
Sbjct: 521 LKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTL 580
Query: 403 VELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWC 440
L + F ++++ L ++ FH +K+ Q C
Sbjct: 581 PRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDC 618
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 79.7 bits (195), Expect = 1e-14
Identities = 95/383 (24%), Positives = 166/383 (43%), Gaps = 60/383 (15%)
Query: 604 GNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQ 663
G P +E++ +S ++R++ +L+ E+ Y+ + + P L P++
Sbjct: 1073 GTPRMERKR---SISAQQRLVSELIACEQDYVATLSEPVP----PPG----PELTPELRG 1121
Query: 664 NNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRAR 723
L R L FH FL+EL+ CA +P + CFL+ + +Y +Y K+ +
Sbjct: 1122 TWAAALSARER-LRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKL- 1179
Query: 724 AIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPG 783
E A + + ++ L + L+ P ++L +Y LL+ LL PE + +
Sbjct: 1180 ----ENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPE-LSSECR 1234
Query: 784 ELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLL 843
LG + + L++ A DL LAV+ AV C D+ + G+LL
Sbjct: 1235 ALGAAVQ-------------LLREQEARGRDL-----LAVE--AVRGCEIDLKEQGQLLH 1274
Query: 844 HGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTM 903
PF+V + K R ++LFE ++F K++ G +G S + +K+
Sbjct: 1275 RDPFTV------------ICGRKKCLRHVFLFEHLLLFSKLK---GPEGGSEMFVYKQAF 1319
Query: 904 KLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
K + + + S FE+ R E Y LQA S EI+ W S I++LL Q +
Sbjct: 1320 KTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAH-- 1377
Query: 962 DQGNPQFEMSTSKGSGAGSGPWI 984
N + + G G+ P++
Sbjct: 1378 ---NKELRVQQMVSMGIGNKPFL 1397
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 75.9 bits (185), Expect = 2e-13
Identities = 98/400 (24%), Positives = 171/400 (42%), Gaps = 69/400 (17%)
Query: 565 LRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRII 624
LR ++E +E ++ +E DE E +S H + E +QQ R +I
Sbjct: 203 LRVNQEELSENSSSTPSEEQDE--------EASQSRHR--HCENKQQMRTN-------VI 245
Query: 625 RDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTF 684
R++++TE +YIK ++ I +GYI KH + +FGNI ++Y+F R F
Sbjct: 246 REIMDTERVYIKHLRDICEGYIRQC----RKHTGMFTVAQLAT-IFGNIEDIYKF-QRKF 299
Query: 685 LKELEK--CAENPEL--LAHCFLKRKEDLQIYFKYHKNLPRA----RAIWQECQDCAYFG 736
LK+LEK E P L + CFL+ +E IY +Y N P A + ++ + +F
Sbjct: 300 LKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFE 359
Query: 737 VC---QRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGP 793
C Q+ +D + + +L P Q++ KY + L LL + + E + + K
Sbjct: 360 ACRLLQQMID--IAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDY------SNIKAAY 411
Query: 794 KRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIH 853
+ K+ A + + +E + K V + E D + + +L+ G +
Sbjct: 412 EAMKNVA--CLINERKRKLESIDKIARWQVSIVG-WEGLDILDRSSELIHSGELT----- 463
Query: 854 KDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQL 913
K + K QR +LF+ +V CK + D +K + + + + L
Sbjct: 464 ------KITKQGKSQQRTFFLFDHQLVSCKKDLLRRDM-----LYYKGRLDMDEMELVDL 512
Query: 914 GRGSHR--------KFEIASRNGLEKYILQAASKEIRDCW 945
G G + F++ SR E Y+ A +E + W
Sbjct: 513 GDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARW 552
>gi|55749621 pleckstrin homology domain containing, family G, member 3
[Homo sapiens]
Length = 1163
Score = 69.7 bits (169), Expect = 1e-11
Identities = 106/470 (22%), Positives = 177/470 (37%), Gaps = 98/470 (20%)
Query: 673 IRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQEC--- 729
+RE+ E R ++++L E+ E IY +Y N P + A EC
Sbjct: 98 VREIVETE-RMYVQDLRSIVESQEF------------DIYTQYCNNYPNSVAALTECMRD 144
Query: 730 -QDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGS 788
Q +F Q L H+LPL YL P QR++KY +LL+ + E+
Sbjct: 145 KQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEE----------- 193
Query: 789 AKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTEC-----PDDIGKLGKLLL 843
DG + +D+ + I D+ + E AV L + D+ G+L+L
Sbjct: 194 --DGFEVVEDAI--DTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVL 249
Query: 844 HGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTM 903
G F V H+ R ++R +LF++ ++ K R GD H+ +K +
Sbjct: 250 EGTFRV---HRVR-----------NERTFFLFDKTLLITKKR---GD-----HFVYKGNI 287
Query: 904 KLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN----- 958
+L + + R S ++ ++Y +QA + E + W I +L++E +
Sbjct: 288 PCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQ 347
Query: 959 ----------------------NIKDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKED 996
+K + Q E+ST+ G K++ R K
Sbjct: 348 KAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEK-- 405
Query: 997 PASSTGGIKGCSSREFSSMDTFEDCEGAE--DMEKESSALSLAGLFQSDDSHETCSSKSA 1054
+ G+KG RE S + G EK S S++ L + + E S +
Sbjct: 406 --ARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEV 463
Query: 1055 FLERGESSQGEKEERDEEETATRSTEEERAGASTGRLA--PAGATAGFQA 1102
F + +G E +T + E + A G L P G F A
Sbjct: 464 F----SAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVA 509
Score = 30.8 bits (68), Expect = 7.5
Identities = 10/27 (37%), Positives = 23/27 (85%)
Query: 617 LSPRRRIIRDLLETEEIYIKEIKSIID 643
LS R++R+++ETE +Y+++++SI++
Sbjct: 91 LSYLGRVVREIVETERMYVQDLRSIVE 117
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 66.6 bits (161), Expect = 1e-10
Identities = 69/267 (25%), Positives = 115/267 (43%), Gaps = 37/267 (13%)
Query: 540 HPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFES 599
H S + S++T+ T P L +S+E ++ + + E+ + S
Sbjct: 964 HSLCSEQGSSAETAPEETEGP---DLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS 1020
Query: 600 HHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIP 659
+ P+L +L D R++I +LLETE Y+K++ +++ Y+ P+ K
Sbjct: 1021 PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQ----KETF- 1075
Query: 660 DVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAE-NPEL---------------LAHCFL 703
+ Q+ D LFGN+ E+ EF FLK LE P+L L FL
Sbjct: 1076 -LTQDELDVLFGNLTEMVEFQVE-FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFL 1133
Query: 704 KRKEDLQIYFKY---HKNLPRARAIWQECQDCAYFGVCQRQ---LDHNLPLFKYLKGPSQ 757
+ ++Y + H +P + + + D A+ Q H+ L YL P Q
Sbjct: 1134 YYADRFKLYSAFCASHTKVP--KVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQ 1191
Query: 758 RLIKYQMLLK---GLLDFESPEDMEID 781
R++KY +LL+ L D ES E +D
Sbjct: 1192 RILKYPLLLRELFALTDAESEEHYHLD 1218
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/168 (29%), Positives = 80/168 (47%), Gaps = 19/168 (11%)
Query: 620 RRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEF 679
R +I ++L TE YIK ++ I +GY+ + + +FGNI ++Y
Sbjct: 285 RTNVINEILSTERDYIKHLRDICEGYVRQ-----CRKRADMFSEEQLRTIFGNIEDIYRC 339
Query: 680 HNRTFLKELEK--CAENPEL--LAHCFLKRKEDLQIYFKYHKNLPRA----RAIWQECQD 731
+ F+K LE+ E P L L CFL+ + D QIY +Y N P A + + +
Sbjct: 340 -QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398
Query: 732 CAYFGVC---QRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPE 776
+F C Q+ +D + L +L P Q++ KY + L LL + P+
Sbjct: 399 VYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQ 444
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/168 (29%), Positives = 80/168 (47%), Gaps = 19/168 (11%)
Query: 620 RRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEF 679
R +I ++L TE YIK ++ I +GY+ + + +FGNI ++Y
Sbjct: 285 RTNVINEILSTERDYIKHLRDICEGYVRQ-----CRKRADMFSEEQLRTIFGNIEDIYRC 339
Query: 680 HNRTFLKELEK--CAENPEL--LAHCFLKRKEDLQIYFKYHKNLPRA----RAIWQECQD 731
+ F+K LE+ E P L L CFL+ + D QIY +Y N P A + + +
Sbjct: 340 -QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398
Query: 732 CAYFGVC---QRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPE 776
+F C Q+ +D + L +L P Q++ KY + L LL + P+
Sbjct: 399 VYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQ 444
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 60.5 bits (145), Expect = 9e-09
Identities = 50/179 (27%), Positives = 87/179 (48%), Gaps = 25/179 (13%)
Query: 607 ELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNK 666
+LE+Q RL R ++ +L +TE Y+ ++ ++ ++ M+ + +V +
Sbjct: 16 DLEKQLRL-----RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETV 70
Query: 667 DFLFGNIRELYEFHNRTFLKELEKCAENPELLAH-----CFLKRKEDLQIYFKYHKNLPR 721
LF NI ++ H + FLK +E+C +PE A CFL K+ +IY +Y N +
Sbjct: 71 KMLFSNIEDILAVH-KEFLKVVEECL-HPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEK 128
Query: 722 ARAIWQECQ----------DCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLL 770
A+ + E +C G + + ++PL YL P QR+ KY ++LK LL
Sbjct: 129 AQKLLLELNKIRTIRTFLLNCMLLG---GRKNTDVPLEGYLVTPIQRICKYPLILKELL 184
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 60.5 bits (145), Expect = 9e-09
Identities = 50/179 (27%), Positives = 87/179 (48%), Gaps = 25/179 (13%)
Query: 607 ELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNK 666
+LE+Q RL R ++ +L +TE Y+ ++ ++ ++ M+ + +V +
Sbjct: 16 DLEKQLRL-----RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETV 70
Query: 667 DFLFGNIRELYEFHNRTFLKELEKCAENPELLAH-----CFLKRKEDLQIYFKYHKNLPR 721
LF NI ++ H + FLK +E+C +PE A CFL K+ +IY +Y N +
Sbjct: 71 KMLFSNIEDILAVH-KEFLKVVEECL-HPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEK 128
Query: 722 ARAIWQECQ----------DCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLL 770
A+ + E +C G + + ++PL YL P QR+ KY ++LK LL
Sbjct: 129 AQKLLLELNKIRTIRTFLLNCMLLG---GRKNTDVPLEGYLVTPIQRICKYPLILKELL 184
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,937,482
Number of Sequences: 37866
Number of extensions: 1918565
Number of successful extensions: 10492
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 189
Number of HSP's that attempted gapping in prelim test: 9387
Number of HSP's gapped (non-prelim): 963
length of query: 1114
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1001
effective length of database: 13,968,660
effective search space: 13982628660
effective search space used: 13982628660
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.