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Search of human proteins with 31657140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
(1297 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 2680 0.0
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 1439 0.0
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 1357 0.0
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 1354 0.0
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 268 3e-71
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 268 3e-71
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 263 8e-70
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 258 3e-68
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 244 4e-64
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 241 3e-63
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 238 3e-62
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 238 3e-62
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 237 5e-62
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 237 5e-62
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 237 5e-62
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 234 3e-61
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 233 9e-61
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 223 7e-58
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 222 2e-57
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 222 2e-57
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 222 2e-57
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 221 4e-57
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 221 4e-57
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 216 9e-56
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 216 9e-56
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 216 9e-56
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 216 9e-56
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 216 1e-55
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 216 1e-55
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 216 1e-55
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 2680 bits (6946), Expect = 0.0
Identities = 1297/1297 (100%), Positives = 1297/1297 (100%)
Query: 1 MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLM 60
MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLM
Sbjct: 1 MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLM 60
Query: 61 FTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEM 120
FTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEM
Sbjct: 61 FTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEM 120
Query: 121 PHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVC 180
PHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVC
Sbjct: 121 PHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVC 180
Query: 181 PGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQP 240
PGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQP
Sbjct: 181 PGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQP 240
Query: 241 EDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSC 300
EDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSC
Sbjct: 241 EDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSC 300
Query: 301 LAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQ 360
LAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQ
Sbjct: 301 LAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQ 360
Query: 361 GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ 420
GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ
Sbjct: 361 GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ 420
Query: 421 NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA 480
NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA
Sbjct: 421 NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA 480
Query: 481 ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT 540
ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT
Sbjct: 481 ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT 540
Query: 541 QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT 600
QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT
Sbjct: 541 QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT 600
Query: 601 LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG 660
LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG
Sbjct: 601 LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG 660
Query: 661 LRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNA 720
LRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNA
Sbjct: 661 LRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNA 720
Query: 721 ITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF 780
ITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF
Sbjct: 721 ITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF 780
Query: 781 TEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPP 840
TEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPP
Sbjct: 781 TEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPP 840
Query: 841 DPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGS 900
DPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGS
Sbjct: 841 DPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGS 900
Query: 901 WTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEY 960
WTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEY
Sbjct: 901 WTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEY 960
Query: 961 FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELAS 1020
FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELAS
Sbjct: 961 FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELAS 1020
Query: 1021 PRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN 1080
PRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN
Sbjct: 1021 PRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN 1080
Query: 1081 NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140
NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV
Sbjct: 1081 NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140
Query: 1141 YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ 1200
YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ
Sbjct: 1141 YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ 1200
Query: 1201 VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY 1260
VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY
Sbjct: 1201 VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY 1260
Query: 1261 YSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH 1297
YSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH
Sbjct: 1261 YSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH 1297
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 1439 bits (3726), Expect = 0.0
Identities = 729/1288 (56%), Positives = 927/1288 (71%), Gaps = 49/1288 (3%)
Query: 9 WGACLPVIFLSLGFGL--DTVEVC-PSLDIRSEVAELRQLENCSVVEGHLQILLMFTATG 65
WG ++FLS L + E+C P +DIR++ +L++LENC+V+EG+L ILL+ A
Sbjct: 14 WG----LLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKA-- 67
Query: 66 EDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRD 125
ED+R FP+LT +T+YLLLFRV GLESL DLFPNL VIRG +LF YALVIFEM +L+D
Sbjct: 68 EDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKD 127
Query: 126 VALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLG 185
+ L L + RGA+R+EKN +LC+LST+DW L+ A N+IVGNK +EC D+CPG +
Sbjct: 128 IGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTME 187
Query: 186 AAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGM-ACTARGECCHTECLGGCSQPEDPR 244
C KTT + +YRCWT++ CQ++CP G ACT ECCH ECLG CS P++
Sbjct: 188 EK-PMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDT 246
Query: 245 ACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRAST-FGIHQGSCLAQ 303
ACVACRH Y+ G C+ ACPP TY++E WRCV + CA++ S S F IH G C+ +
Sbjct: 247 ACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQE 306
Query: 304 CPSGFTRNSS-SIFCHKCEGLCPKECKVG--TKTIDSIQAAQDLVGCTHVEGSLILNLRQ 360
CPSGF RN S S++C CEG CPK C+ TKTIDS+ +AQ L GCT +G+L++N+R+
Sbjct: 307 CPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRR 366
Query: 361 GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ 420
G N+ +L++ +GL+E +TG++KI+HS ALVSL F KNL+LI G+ ++GNY+ YVLDNQ
Sbjct: 367 GNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQ 426
Query: 421 NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA 480
NLQQL W LTI GK+YFAFNP+LC+ IYR+EEVTGT+GRQ+K +IN R NG+RA
Sbjct: 427 NLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERA 486
Query: 481 ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT 540
+C++ L F S T +RI++ W RY P + RDL+SF VYYKE+PF+N TE+ G DACG+
Sbjct: 487 SCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGS 546
Query: 541 QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT 600
SWN++DV+LP ++ EPG+ L LKPWTQYAV+V+A+TLT E+ +GA+S I+Y+RT
Sbjct: 547 NSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRT 606
Query: 601 LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG 660
+ P++P DV+S SNSSS L+V+W PP+ NGNL+YY+V WQR +DG LY ++YC +
Sbjct: 607 NASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD 666
Query: 661 LRLPTSNNDPRFDGED--GDPEAEM----ESDCCPCQHPPPGQVLPPLEAQEASFQKKFE 714
D D E+ +P+ E+ + CC C P + E +EA ++K FE
Sbjct: 667 KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAEYRKVFE 723
Query: 715 NFLHNAITIPISPWK---VTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVP--- 768
NFLHN+I +P K V + + R+ AA N +D E E + P
Sbjct: 724 NFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTY----NITDPEELETEYPFFE 779
Query: 769 -----RERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVA 823
+ER V+S LR FT YRIDIH+CNH A +GCSA+ FVFARTMP AD IPG V
Sbjct: 780 SRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVT 839
Query: 824 WEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPP 883
WE +NS+ L+W EP +PNGLIL YEIKY E+ CVSR Y K+GG L L P
Sbjct: 840 WEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRE-CVSRQEYRKYGGAKLNRLNP 898
Query: 884 GNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIV-LAALGF 942
GNY+AR++ATSL+GNGSWTD V FY+ + +H+++ A PV + L++ L + +
Sbjct: 899 GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYE-NFIHLII-ALPVAVLLIVGGLVIMLY 956
Query: 943 FYGKKRNRT------LYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEG 996
+ +KRN + LYASVNPEYFSA+D+YVPDEWEV RE+I++ RELGQGSFGMVYEG
Sbjct: 957 VFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEG 1016
Query: 997 LARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTL 1056
+A+G+ E T VA+KTVNE AS RE IEFL EASVMK F CHHVVRLLGVVSQGQPTL
Sbjct: 1017 VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL 1076
Query: 1057 VIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDL 1116
VIMELMTRGDLKS+LRSLRPE ENNP L P+L +MIQMAGEIADGMAYL ANKFVHRDL
Sbjct: 1077 VIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDL 1136
Query: 1117 AARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVW 1176
AARNCMV++DFTVKIGDFGMTRD+YETDYYRKGGKGLLPVRWM+PESLKDG+FTT+SDVW
Sbjct: 1137 AARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVW 1196
Query: 1177 SFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLR 1236
SFGVVLWEI TLAEQPYQGLSNEQVL+FVM+GG+L++ + CP L ELM CWQ NP++R
Sbjct: 1197 SFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256
Query: 1237 PSFTHILDSIQEELRPSFRLLSFYYSPE 1264
PSF I+ SI+EE+ P FR +SFYYS E
Sbjct: 1257 PSFLEIISSIKEEMEPGFREVSFYYSEE 1284
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 1357 bits (3511), Expect = 0.0
Identities = 694/1277 (54%), Positives = 876/1277 (68%), Gaps = 53/1277 (4%)
Query: 28 EVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFR 87
EVCP +DIR+ + L +LENCSV+EGHLQILLMF EDFR LSFP+L +TDYLLLFR
Sbjct: 33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFR 92
Query: 88 VYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQEL 147
VYGLESL+DLFPNL VIRG+RLF YALVIFEM HL+++ L L + RG+VR+EKN EL
Sbjct: 93 VYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNEL 152
Query: 148 CHLSTIDWGLLQPAPGANHIVGNKL-GEECADVCPGVLGAAGEP-CAKTTFSGHTDYRCW 205
C+L+TIDW + + N+IV NK EEC D+CPG A G+ C T +G RCW
Sbjct: 153 CYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGT--AKGKTNCPATVINGQFVERCW 210
Query: 206 TSSHCQRVCPC---PHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWAC 262
T SHCQ+VCP HG CTA G CCH+ECLG CSQP+DP CVACR+ Y G C+ C
Sbjct: 211 THSHCQKVCPTICKSHG--CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETC 268
Query: 263 PPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQ-----GSCLAQCPSGFTRNSSSIFC 317
PP Y ++ WRCV C LH + G HQ C+ +CPSG+T NSS++ C
Sbjct: 269 PPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLC 328
Query: 318 HKCEGLCPKECKV--GTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLV 375
C G CPK C + G KTIDS+ +AQ+L GCT + GSLI+N+R G NL +L+ +LGL+
Sbjct: 329 TPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLI 388
Query: 376 ETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTI 435
E I+G+LKI+ S+ALVSL FF+ L+LIRG+ + GNY+ Y LDNQNL+QL W LTI
Sbjct: 389 EEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTI 448
Query: 436 PVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTE 495
GK++F +NP+LCL I+++EEV+GT+GRQ + +I +TNGD+A+C+ L+F T
Sbjct: 449 TQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTS 508
Query: 496 ADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRT 555
D+ILLRWE Y P + RDLL F+++YKE+P+QN TE G DACG+ SW ++D++ PL
Sbjct: 509 FDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSN 568
Query: 556 Q-----EPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQD 610
PG + LKPWTQYA+FV+ + ++E + GA+S I+Y++T P+VP D
Sbjct: 569 DPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTY-GAKSDIIYVQTDATNPSVPLD 627
Query: 611 VISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDP 670
IS SNSSS ++++WKPP+ NGN+T+YLV W+R AED +L+ DYC +GL+LP+ P
Sbjct: 628 PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSP 687
Query: 671 RFDGEDGDPEAEME-----SDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPI 725
F+ ED + E +CC C Q+L LE E+SF+K FE++LHN + +P
Sbjct: 688 PFESEDSQKHNQSEYEDSAGECCSCPKTD-SQILKELE--ESSFRKTFEDYLHNVVFVPR 744
Query: 726 SPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQ---------EDKVPRERAVLSG 776
K S+ D G A + N+S + E V +E V+SG
Sbjct: 745 PSRKRRSLG-----DVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISG 799
Query: 777 LRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRW 836
LRHFT YRI++ ACN CS A +V ARTMP +AD I G V E N V L W
Sbjct: 800 LRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW 859
Query: 837 LEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLA 896
EP +PNGLI+ YE+ YRR G+E LCVSR +A G L L PGNYS R+RATSLA
Sbjct: 860 QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLA 919
Query: 897 GNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNR----TL 952
GNGSWT+ FY+ + + +++ +V+ ++ F K++ L
Sbjct: 920 GNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPL 979
Query: 953 YASVNPEYFSASDM-----YVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEES 1007
YAS NPEY SASD+ YVPDEWEV RE+I+++RELGQGSFGMVYEG AR + GE
Sbjct: 980 YASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 1039
Query: 1008 TPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDL 1067
T VA+KTVNE AS RE IEFL EASVMK F CHHVVRLLGVVS+GQPTLV+MELM GDL
Sbjct: 1040 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDL 1099
Query: 1068 KSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDF 1127
KS+LRSLRPEAENNPG P P L EMIQMA EIADGMAYL A KFVHRDLAARNCMV+ DF
Sbjct: 1100 KSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF 1159
Query: 1128 TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVT 1187
TVKIGDFGMTRD+YETDYYRKGGKGLLPVRWMAPESLKDG+FTT SD+WSFGVVLWEI +
Sbjct: 1160 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITS 1219
Query: 1188 LAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
LAEQPYQGLSNEQVLKFVMDGG L++ + CP ++ +LM CWQ NP++RP+F I++ ++
Sbjct: 1220 LAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
Query: 1248 EELRPSFRLLSFYYSPE 1264
++L PSF +SF++S E
Sbjct: 1280 DDLHPSFPEVSFFHSEE 1296
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 1354 bits (3504), Expect = 0.0
Identities = 695/1284 (54%), Positives = 877/1284 (68%), Gaps = 55/1284 (4%)
Query: 28 EVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFR 87
EVCP +DIR+ + L +LENCSV+EGHLQILLMF EDFR LSFP+L +TDYLLLFR
Sbjct: 33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFR 92
Query: 88 VYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQEL 147
VYGLESL+DLFPNL VIRG+RLF YALVIFEM HL+++ L L + RG+VR+EKN EL
Sbjct: 93 VYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNEL 152
Query: 148 CHLSTIDWGLLQPAPGANHIVGNKL-GEECADVCPGVLGAAGEP-CAKTTFSGHTDYRCW 205
C+L+TIDW + + N+IV NK EEC D+CPG A G+ C T +G RCW
Sbjct: 153 CYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGT--AKGKTNCPATVINGQFVERCW 210
Query: 206 TSSHCQRVCPC---PHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWAC 262
T SHCQ+VCP HG CTA G CCH+ECLG CSQP+DP CVACR+ Y G C+ C
Sbjct: 211 THSHCQKVCPTICKSHG--CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETC 268
Query: 263 PPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQ-----GSCLAQCPSGFTRNSSSIFC 317
PP Y ++ WRCV C LH + G HQ C+ +CPSG+T NSS++ C
Sbjct: 269 PPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLC 328
Query: 318 HKCEGLCPKECKV--GTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLV 375
C G CPK C + G KTIDS+ +AQ+L GCT + GSLI+N+R G NL +L+ +LGL+
Sbjct: 329 TPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLI 388
Query: 376 ETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTI 435
E I+G+LKI+ S+ALVSL FF+ L+LIRG+ + GNY+ Y LDNQNL+QL W LTI
Sbjct: 389 EEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTI 448
Query: 436 PVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTE 495
GK++F +NP+LCL I+++EEV+GT+GRQ + +I +TNGD+A+C+ L+F T
Sbjct: 449 TQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTS 508
Query: 496 ADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRT 555
D+ILLRWE Y P + RDLL F+++YKE+P+QN TE G DACG+ SW ++D++ PL
Sbjct: 509 FDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSN 568
Query: 556 Q-----EPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQD 610
PG + LKPWTQYA+FV+ + ++E + GA+S I+Y++T P+VP D
Sbjct: 569 DPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTY-GAKSDIIYVQTDATNPSVPLD 627
Query: 611 VISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDP 670
IS SNSSS ++++WKPP+ NGN+T+YLV W+R AED +L+ DYC +GL+LP+ P
Sbjct: 628 PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSP 687
Query: 671 RFDGEDGDPEAEME-----SDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPI 725
F+ ED + E +CC C Q+L LE E+SF+K FE++LHN + +P
Sbjct: 688 PFESEDSQKHNQSEYEDSAGECCSCPKTD-SQILKELE--ESSFRKTFEDYLHNVVFVPR 744
Query: 726 SPWKVTSI-NKSPQR------DSGRHRRAAGPLRLGGNSSDFEIQ---------EDKVPR 769
T + P R D G A + N+S + E V +
Sbjct: 745 KTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNK 804
Query: 770 ERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSK 829
E V+SGLRHFT YRI++ ACN CS A +V ARTMP +AD I G V E
Sbjct: 805 ESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN 864
Query: 830 NSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSAR 889
N V L W EP +PNGLI+ YE+ YRR G+E LCVSR +A G L L PGNYS R
Sbjct: 865 NVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR 924
Query: 890 VRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRN 949
+RATSLAGNGSWT+ FY+ + + +++ +V+ ++ F K++
Sbjct: 925 IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQP 984
Query: 950 R----TLYASVNPEYFSASDM-----YVPDEWEVPREQISIIRELGQGSFGMVYEGLARG 1000
LYAS NPEY SASD+ YVPDEWEV RE+I+++RELGQGSFGMVYEG AR
Sbjct: 985 DGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARD 1044
Query: 1001 LEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIME 1060
+ GE T VA+KTVNE AS RE IEFL EASVMK F CHHVVRLLGVVS+GQPTLV+ME
Sbjct: 1045 IIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 1104
Query: 1061 LMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARN 1120
LM GDLKS+LRSLRPEAENNPG P P L EMIQMA EIADGMAYL A KFVHRDLAARN
Sbjct: 1105 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARN 1164
Query: 1121 CMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGV 1180
CMV+ DFTVKIGDFGMTRD+YETDYYRKGGKGLLPVRWMAPESLKDG+FTT SD+WSFGV
Sbjct: 1165 CMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV 1224
Query: 1181 VLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240
VLWEI +LAEQPYQGLSNEQVLKFVMDGG L++ + CP ++ +LM CWQ NP++RP+F
Sbjct: 1225 VLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1284
Query: 1241 HILDSIQEELRPSFRLLSFYYSPE 1264
I++ ++++L PSF +SF++S E
Sbjct: 1285 EIVNLLKDDLHPSFPEVSFFHSEE 1308
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 268 bits (685), Expect = 3e-71
Identities = 140/332 (42%), Positives = 203/332 (61%), Gaps = 14/332 (4%)
Query: 969 PDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFL 1028
P EV ++++R LG G+FG VYEGL GL VA+KT+ EL SP++ ++FL
Sbjct: 500 PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 559
Query: 1029 KEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP- 1087
EA ++ F+ ++VR +G+ + P L+++ELM+ GD+KS LR RP G P P
Sbjct: 560 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 615
Query: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS---QDFTVKIGDFGMTRDVYETD 1144
+ +++Q+A +IA G YL N F+HRD+AARNC++S KIGDFGM RD+Y
Sbjct: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
Query: 1145 YYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF 1204
YYR+G + LLPV+WM PE+ +GIFT+ +D WSFGV+LWEI +L PY G +N++VL F
Sbjct: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
Query: 1205 VMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ-----EELRPSFRLLSF 1259
V+ GG ++ GCP + +M++CWQ P LRPSF IL+ +Q ++ S +
Sbjct: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMEL 795
Query: 1260 YYSPECRGARGSLPTTDAEPDSSPTPRDCSPQ 1291
+PE G G L E P P++ SP+
Sbjct: 796 GPTPEEEGTSG-LGNRSLECLRPPQPQELSPE 826
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 268 bits (685), Expect = 3e-71
Identities = 140/332 (42%), Positives = 203/332 (61%), Gaps = 14/332 (4%)
Query: 969 PDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFL 1028
P EV ++++R LG G+FG VYEGL GL VA+KT+ EL SP++ ++FL
Sbjct: 439 PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 498
Query: 1029 KEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP- 1087
EA ++ F+ ++VR +G+ + P L+++ELM+ GD+KS LR RP G P P
Sbjct: 499 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 554
Query: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS---QDFTVKIGDFGMTRDVYETD 1144
+ +++Q+A +IA G YL N F+HRD+AARNC++S KIGDFGM RD+Y
Sbjct: 555 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 614
Query: 1145 YYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF 1204
YYR+G + LLPV+WM PE+ +GIFT+ +D WSFGV+LWEI +L PY G +N++VL F
Sbjct: 615 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 674
Query: 1205 VMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ-----EELRPSFRLLSF 1259
V+ GG ++ GCP + +M++CWQ P LRPSF IL+ +Q ++ S +
Sbjct: 675 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMEL 734
Query: 1260 YYSPECRGARGSLPTTDAEPDSSPTPRDCSPQ 1291
+PE G G L E P P++ SP+
Sbjct: 735 GPTPEEEGTSG-LGNRSLECLRPPQPQELSPE 765
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 263 bits (672), Expect = 8e-70
Identities = 133/306 (43%), Positives = 189/306 (61%), Gaps = 7/306 (2%)
Query: 946 KKRNRTLYASVNPEY-FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG 1004
K R T+ NP Y F+ + D EVPR+ I++IR LG G+FG VYEG G+
Sbjct: 1082 KLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPND 1141
Query: 1005 EESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTR 1064
VA+KT+ E+ S ++ ++FL EA ++ F ++VR +GV Q P +++ELM
Sbjct: 1142 PSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG 1201
Query: 1065 GDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS 1124
GDLKS LR RP L A+ +++ +A +IA G YL N F+HRD+AARNC+++
Sbjct: 1202 GDLKSFLRETRPRPSQPSSL---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT 1258
Query: 1125 ---QDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVV 1181
KIGDFGM RD+Y YYRKGG +LPV+WM PE+ +GIFT+ +D WSFGV+
Sbjct: 1259 CPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVL 1318
Query: 1182 LWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTH 1241
LWEI +L PY SN++VL+FV GG ++ + CP + +M++CWQ P RP+F
Sbjct: 1319 LWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI 1378
Query: 1242 ILDSIQ 1247
IL+ I+
Sbjct: 1379 ILERIE 1384
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 258 bits (658), Expect = 3e-68
Identities = 143/294 (48%), Positives = 188/294 (63%), Gaps = 11/294 (3%)
Query: 975 PREQISIIRELGQGSFGMVYEGLARG-LEAGEESTPVALKTVNELASPRECIEFLKEASV 1033
PRE++++ LG G+FG VYEG A L G VA+KT+ + ++ +E IEFLKEA +
Sbjct: 1941 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 2000
Query: 1034 MKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMI 1093
M F ++++ LGV +P +I+ELM GDL ++LR R P L L +++
Sbjct: 2001 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLV 2057
Query: 1094 QMAGEIADGMAYLAANKFVHRDLAARNCMVS-QDFT----VKIGDFGMTRDVYETDYYRK 1148
+ +I+ G YL F+HRDLAARNC+VS +D+T VKIGDFG+ RD+Y+ DYYRK
Sbjct: 2058 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 2117
Query: 1149 GGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDG 1208
G+GLLPVRWMAPESL DGIFTT SDVWSFG+++WEI+TL QPY SN VL +V G
Sbjct: 2118 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 2177
Query: 1209 GVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYS 1262
G LE CP L LM++CW P RP+F I D +Q L +F L S Y S
Sbjct: 2178 GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ--LFRNFFLNSIYKS 2229
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 244 bits (623), Expect = 4e-64
Identities = 158/457 (34%), Positives = 241/457 (52%), Gaps = 43/457 (9%)
Query: 819 PGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHL 878
P KV E S S+ + W PP + KYE+ YR+ G+ + +R + V L
Sbjct: 439 PPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSY----NVRRTEGFSVTL 494
Query: 879 A-LLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVL 937
L P Y +V+A + G G+ + F L PE G ++ VG+ LL+VL
Sbjct: 495 DDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPE---GSGNLAVIGGVAVGVVLLLVL 551
Query: 938 AALGFFYGKKR-NRTLYASVNPEYFSASDM------YV-PDEWEVPREQI---------- 979
A +GFF ++R N+ S YFS S+ YV P +E P + +
Sbjct: 552 AGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPS 611
Query: 980 SIIRE--LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAF 1037
+ R+ +G G FG VY+G+ + +G++ PVA+KT+ + ++ ++FL EA +M F
Sbjct: 612 CVTRQKVIGAGEFGEVYKGMLK-TSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQF 670
Query: 1038 KCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAG 1097
H+++RL GV+S+ +P ++I E M G L LR E ++ +++ M
Sbjct: 671 SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEF---------SVLQLVGMLR 721
Query: 1098 EIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTR---DVYETDYYRKGGKGLL 1154
IA GM YLA +VHRDLAARN +V+ + K+ DFG++R D E Y GGK +
Sbjct: 722 GIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK--I 779
Query: 1155 PVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEEL 1214
P+RW APE++ FT+ SDVWSFG+V+WE++T E+PY LSN +V+K + DG L
Sbjct: 780 PIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTP 839
Query: 1215 EGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELR 1251
CP + +LM +CWQ RP F I+ + + +R
Sbjct: 840 MDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR 876
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 241 bits (616), Expect = 3e-63
Identities = 121/284 (42%), Positives = 174/284 (61%), Gaps = 14/284 (4%)
Query: 973 EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032
E PR I +R++G+G+FG V++ A GL E T VA+K + E AS +F +EA+
Sbjct: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
Query: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE------------- 1079
+M F ++V+LLGV + G+P ++ E M GDL LRS+ P
Sbjct: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
Query: 1080 -NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTR 1138
++PG P + E + +A ++A GMAYL+ KFVHRDLA RNC+V ++ VKI DFG++R
Sbjct: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
Query: 1139 DVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSN 1198
++Y DYY+ +P+RWM PES+ +TT SDVW++GVVLWEI + QPY G+++
Sbjct: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
Query: 1199 EQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI 1242
E+V+ +V DG +L E CP++L LM CW P RPSFT I
Sbjct: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 238 bits (607), Expect = 3e-62
Identities = 129/304 (42%), Positives = 183/304 (60%), Gaps = 9/304 (2%)
Query: 957 NPEYFSASDMYV-PDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
NP+YF ++ + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 513 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 572
Query: 1014 TVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRS 1073
T+ + AS +F +EA ++ + H+V+ GV +G P +++ E M GDL LR+
Sbjct: 573 TLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 631
Query: 1074 LRPEA----ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV 1129
P+A E NP + +M+ +A +IA GM YLA+ FVHRDLA RNC+V ++ V
Sbjct: 632 HGPDAVLMAEGNPPT-ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 690
Query: 1130 KIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLA 1189
KIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 691 KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG 750
Query: 1190 EQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEE 1249
+QP+ LSN +V++ + G VL+ CP ++ ELM CWQ P +R + I +Q
Sbjct: 751 KQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 810
Query: 1250 LRPS 1253
+ S
Sbjct: 811 AKAS 814
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 238 bits (607), Expect = 3e-62
Identities = 129/304 (42%), Positives = 183/304 (60%), Gaps = 9/304 (2%)
Query: 957 NPEYFSASDMYV-PDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
NP+YF ++ + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 529 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 588
Query: 1014 TVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRS 1073
T+ + AS +F +EA ++ + H+V+ GV +G P +++ E M GDL LR+
Sbjct: 589 TLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 647
Query: 1074 LRPEA----ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV 1129
P+A E NP + +M+ +A +IA GM YLA+ FVHRDLA RNC+V ++ V
Sbjct: 648 HGPDAVLMAEGNPPT-ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 706
Query: 1130 KIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLA 1189
KIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 707 KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG 766
Query: 1190 EQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEE 1249
+QP+ LSN +V++ + G VL+ CP ++ ELM CWQ P +R + I +Q
Sbjct: 767 KQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 826
Query: 1250 LRPS 1253
+ S
Sbjct: 827 AKAS 830
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 237 bits (605), Expect = 5e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 487 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
Query: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 542 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
Query: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
Query: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
Query: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 776
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 237 bits (605), Expect = 5e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 493 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
Query: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 548 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
Query: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
Query: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 726
Query: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 727 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 782
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 237 bits (605), Expect = 5e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 457 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
Query: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 512 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
Query: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
Query: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
Query: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 691 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 746
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 234 bits (598), Expect = 3e-61
Identities = 123/297 (41%), Positives = 182/297 (61%), Gaps = 14/297 (4%)
Query: 1004 GEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMT 1063
G S + +T+ EL SP++ ++FL EA ++ F+ ++VR +G+ + P L+++ELM+
Sbjct: 405 GFPSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMS 464
Query: 1064 RGDLKSHLRSLRPEAENNPGLPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCM 1122
GD+KS LR RP G P P + +++Q+A +IA G YL N F+HRD+AARNC+
Sbjct: 465 GGDMKSFLRHSRPHL----GQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCL 520
Query: 1123 VS---QDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFG 1179
+S KIGDFGM RD+Y YYR+G + LLPV+WM PE+ +GIFT+ +D WSFG
Sbjct: 521 LSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFG 580
Query: 1180 VVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSF 1239
V+LWEI +L PY G +N++VL FV+ GG ++ GCP + +M++CWQ P LRPSF
Sbjct: 581 VLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSF 640
Query: 1240 THILDSIQ-----EELRPSFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQ 1291
IL+ +Q ++ S + +PE G G L E P P++ SP+
Sbjct: 641 ASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG-LGNRSLECLRPPQPQELSPE 696
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 233 bits (594), Expect = 9e-61
Identities = 127/297 (42%), Positives = 179/297 (60%), Gaps = 14/297 (4%)
Query: 957 NPEYF-SASDMYVPDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
NP+YF + + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
Query: 1014 TVNE--LASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHL 1071
+ + LA+ ++ F +EA ++ + H+V+ GV G P +++ E M GDL L
Sbjct: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
Query: 1072 RSLRPEAENN-PGLPQPALGE-----MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ 1125
R+ P+A G P+ A GE M+ +A +IA GM YLA+ FVHRDLA RNC+V
Sbjct: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689
Query: 1126 DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEI 1185
+ VKIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT SDVWSFGV+LWEI
Sbjct: 690 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 749
Query: 1186 VTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI 1242
T +QP+ LSN +V++ + G VLE CP ++ ++M CWQ P+ R + I
Sbjct: 750 FTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
precursor [Homo sapiens]
Length = 839
Score = 223 bits (569), Expect = 7e-58
Identities = 127/311 (40%), Positives = 179/311 (57%), Gaps = 28/311 (9%)
Query: 957 NPEYF-SASDMYVPDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
NP+YF + + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
Query: 1014 TVNE--LASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHL 1071
+ + LA+ ++ F +EA ++ + H+V+ GV G P +++ E M GDL L
Sbjct: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
Query: 1072 RSLRPEAENN-PGLPQPALGE-----MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ 1125
R+ P+A G P+ A GE M+ +A +IA GM YLA+ FVHRDLA RNC+V
Sbjct: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689
Query: 1126 DFTVKIGDFGMTRDVYETDYYRK--------------GGKGLLPVRWMAPESLKDGIFTT 1171
+ VKIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT
Sbjct: 690 NLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTT 749
Query: 1172 HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQP 1231
SDVWSFGV+LWEI T +QP+ LSN +V++ + G VLE CP ++ ++M CWQ
Sbjct: 750 ESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQR 809
Query: 1232 NPRLRPSFTHI 1242
P+ R + I
Sbjct: 810 EPQQRLNIKEI 820
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 222 bits (565), Expect = 2e-57
Identities = 123/347 (35%), Positives = 195/347 (56%), Gaps = 15/347 (4%)
Query: 965 DMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG--EESTPVALKTVNELASPR 1022
D+ + WE PR+++ + + LG+G FG V A G++ ++++ VA+K + + AS +
Sbjct: 413 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK 472
Query: 1023 ECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN- 1080
+ + + E VMK H +++ LLGV +Q P VI+E +G+L+ LR+ RP +
Sbjct: 473 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 532
Query: 1081 NPGLPQPALGEM-----IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFG 1135
+P P+ + G + + A ++A GM YL + K +HRDLAARN +V++D +KI DFG
Sbjct: 533 SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 592
Query: 1136 MTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG 1195
+ R V+ DYY+K G LPV+WMAPE+L D ++T SDVWSFG++LWEI TL PY G
Sbjct: 593 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 652
Query: 1196 LSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRP--- 1252
+ E++ + +G ++ CP +L LM CW P RP+F +++++ + L
Sbjct: 653 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 712
Query: 1253 ---SFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPG 1296
RL YSP A + ++D+ P P S G G
Sbjct: 713 EYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSG 759
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 222 bits (565), Expect = 2e-57
Identities = 123/347 (35%), Positives = 195/347 (56%), Gaps = 15/347 (4%)
Query: 965 DMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG--EESTPVALKTVNELASPR 1022
D+ + WE PR+++ + + LG+G FG V A G++ ++++ VA+K + + AS +
Sbjct: 453 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK 512
Query: 1023 ECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN- 1080
+ + + E VMK H +++ LLGV +Q P VI+E +G+L+ LR+ RP +
Sbjct: 513 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 572
Query: 1081 NPGLPQPALGEM-----IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFG 1135
+P P+ + G + + A ++A GM YL + K +HRDLAARN +V++D +KI DFG
Sbjct: 573 SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 632
Query: 1136 MTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG 1195
+ R V+ DYY+K G LPV+WMAPE+L D ++T SDVWSFG++LWEI TL PY G
Sbjct: 633 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 692
Query: 1196 LSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRP--- 1252
+ E++ + +G ++ CP +L LM CW P RP+F +++++ + L
Sbjct: 693 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 752
Query: 1253 ---SFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPG 1296
RL YSP A + ++D+ P P S G G
Sbjct: 753 EYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSG 799
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 222 bits (565), Expect = 2e-57
Identities = 123/347 (35%), Positives = 195/347 (56%), Gaps = 15/347 (4%)
Query: 965 DMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG--EESTPVALKTVNELASPR 1022
D+ + WE PR+++ + + LG+G FG V A G++ ++++ VA+K + + AS +
Sbjct: 453 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK 512
Query: 1023 ECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN- 1080
+ + + E VMK H +++ LLGV +Q P VI+E +G+L+ LR+ RP +
Sbjct: 513 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 572
Query: 1081 NPGLPQPALGEM-----IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFG 1135
+P P+ + G + + A ++A GM YL + K +HRDLAARN +V++D +KI DFG
Sbjct: 573 SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 632
Query: 1136 MTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG 1195
+ R V+ DYY+K G LPV+WMAPE+L D ++T SDVWSFG++LWEI TL PY G
Sbjct: 633 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 692
Query: 1196 LSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRP--- 1252
+ E++ + +G ++ CP +L LM CW P RP+F +++++ + L
Sbjct: 693 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 752
Query: 1253 ---SFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPG 1296
RL YSP A + ++D+ P P S G G
Sbjct: 753 EYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSG 799
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 221 bits (563), Expect = 4e-57
Identities = 120/292 (41%), Positives = 169/292 (57%), Gaps = 14/292 (4%)
Query: 971 EWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKE 1030
+WE PR+ + + + LG+G FG V + A L+ T VA+K + E ASP E + L E
Sbjct: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
Query: 1031 ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE---------AENN 1081
+V+K HV++L G SQ P L+I+E G L+ LR R + N+
Sbjct: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
Query: 1082 PGLPQP-----ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGM 1136
L P +G++I A +I+ GM YLA K VHRDLAARN +V++ +KI DFG+
Sbjct: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
Query: 1137 TRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL 1196
+RDVYE D Y K +G +PV+WMA ESL D I+TT SDVWSFGV+LWEIVTL PY G+
Sbjct: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
Query: 1197 SNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE 1248
E++ + G +E + C ++ LM +CW+ P RP F I +++
Sbjct: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 221 bits (563), Expect = 4e-57
Identities = 120/292 (41%), Positives = 169/292 (57%), Gaps = 14/292 (4%)
Query: 971 EWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKE 1030
+WE PR+ + + + LG+G FG V + A L+ T VA+K + E ASP E + L E
Sbjct: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
Query: 1031 ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE---------AENN 1081
+V+K HV++L G SQ P L+I+E G L+ LR R + N+
Sbjct: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
Query: 1082 PGLPQP-----ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGM 1136
L P +G++I A +I+ GM YLA K VHRDLAARN +V++ +KI DFG+
Sbjct: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
Query: 1137 TRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL 1196
+RDVYE D Y K +G +PV+WMA ESL D I+TT SDVWSFGV+LWEIVTL PY G+
Sbjct: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
Query: 1197 SNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE 1248
E++ + G +E + C ++ LM +CW+ P RP F I +++
Sbjct: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 216 bits (551), Expect = 9e-56
Identities = 130/369 (35%), Positives = 207/369 (56%), Gaps = 27/369 (7%)
Query: 948 RNRTLYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGE 1005
R L +S P S+ +P++ WE+PR+++ + + LG+G FG V A GL+ +
Sbjct: 354 RPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK 413
Query: 1006 ES--TPVALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELM 1062
+ T VA+K + A+ ++ + + E +MK H +++ LLG +Q P VI+E
Sbjct: 414 PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 473
Query: 1063 TRGDLKSHLRSLRPEA-------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRD 1115
++G+L+ +L++ RP +NP Q + +++ A ++A GM YLA+ K +HRD
Sbjct: 474 SKGNLREYLQARRPPGLEYCYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASKKCIHRD 532
Query: 1116 LAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDV 1175
LAARN +V++D +KI DFG+ RD++ DYY+K G LPV+WMAPE+L D I+T SDV
Sbjct: 533 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 592
Query: 1176 WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRL 1235
WSFGV+LWEI TL PY G+ E++ K + +G +++ C +L +M CW P
Sbjct: 593 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 652
Query: 1236 RPSFTHILDSI---------QEELRPSFRLLSFYYSPECRGARGSLPTT--DAEPDSSPT 1284
RP+F +++ + QE L S L YSP R S ++ D+ P
Sbjct: 653 RPTFKQLVEDLDRIVALTSNQEYLDLSMPL--DQYSPSFPDTRSSTCSSGEDSVFSHEPL 710
Query: 1285 PRD-CSPQN 1292
P + C P++
Sbjct: 711 PEEPCLPRH 719
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 216 bits (551), Expect = 9e-56
Identities = 130/369 (35%), Positives = 207/369 (56%), Gaps = 27/369 (7%)
Query: 948 RNRTLYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGE 1005
R L +S P S+ +P++ WE+PR+++ + + LG+G FG V A GL+ +
Sbjct: 356 RPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK 415
Query: 1006 ES--TPVALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELM 1062
+ T VA+K + A+ ++ + + E +MK H +++ LLG +Q P VI+E
Sbjct: 416 PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 475
Query: 1063 TRGDLKSHLRSLRPEA-------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRD 1115
++G+L+ +L++ RP +NP Q + +++ A ++A GM YLA+ K +HRD
Sbjct: 476 SKGNLREYLQARRPPGLEYCYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASKKCIHRD 534
Query: 1116 LAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDV 1175
LAARN +V++D +KI DFG+ RD++ DYY+K G LPV+WMAPE+L D I+T SDV
Sbjct: 535 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 594
Query: 1176 WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRL 1235
WSFGV+LWEI TL PY G+ E++ K + +G +++ C +L +M CW P
Sbjct: 595 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 654
Query: 1236 RPSFTHILDSI---------QEELRPSFRLLSFYYSPECRGARGSLPTT--DAEPDSSPT 1284
RP+F +++ + QE L S L YSP R S ++ D+ P
Sbjct: 655 RPTFKQLVEDLDRIVALTSNQEYLDLSMPL--DQYSPSFPDTRSSTCSSGEDSVFSHEPL 712
Query: 1285 PRD-CSPQN 1292
P + C P++
Sbjct: 713 PEEPCLPRH 721
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 216 bits (551), Expect = 9e-56
Identities = 130/369 (35%), Positives = 207/369 (56%), Gaps = 27/369 (7%)
Query: 948 RNRTLYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGE 1005
R L +S P S+ +P++ WE+PR+++ + + LG+G FG V A GL+ +
Sbjct: 443 RPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK 502
Query: 1006 ES--TPVALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELM 1062
+ T VA+K + A+ ++ + + E +MK H +++ LLG +Q P VI+E
Sbjct: 503 PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 562
Query: 1063 TRGDLKSHLRSLRPEA-------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRD 1115
++G+L+ +L++ RP +NP Q + +++ A ++A GM YLA+ K +HRD
Sbjct: 563 SKGNLREYLQARRPPGLEYCYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASKKCIHRD 621
Query: 1116 LAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDV 1175
LAARN +V++D +KI DFG+ RD++ DYY+K G LPV+WMAPE+L D I+T SDV
Sbjct: 622 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 681
Query: 1176 WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRL 1235
WSFGV+LWEI TL PY G+ E++ K + +G +++ C +L +M CW P
Sbjct: 682 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 741
Query: 1236 RPSFTHILDSI---------QEELRPSFRLLSFYYSPECRGARGSLPTT--DAEPDSSPT 1284
RP+F +++ + QE L S L YSP R S ++ D+ P
Sbjct: 742 RPTFKQLVEDLDRIVALTSNQEYLDLSMPL--DQYSPSFPDTRSSTCSSGEDSVFSHEPL 799
Query: 1285 PRD-CSPQN 1292
P + C P++
Sbjct: 800 PEEPCLPRH 808
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 216 bits (551), Expect = 9e-56
Identities = 130/369 (35%), Positives = 207/369 (56%), Gaps = 27/369 (7%)
Query: 948 RNRTLYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGE 1005
R L +S P S+ +P++ WE+PR+++ + + LG+G FG V A GL+ +
Sbjct: 445 RPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK 504
Query: 1006 ES--TPVALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELM 1062
+ T VA+K + A+ ++ + + E +MK H +++ LLG +Q P VI+E
Sbjct: 505 PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 564
Query: 1063 TRGDLKSHLRSLRPEA-------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRD 1115
++G+L+ +L++ RP +NP Q + +++ A ++A GM YLA+ K +HRD
Sbjct: 565 SKGNLREYLQARRPPGLEYCYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASKKCIHRD 623
Query: 1116 LAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDV 1175
LAARN +V++D +KI DFG+ RD++ DYY+K G LPV+WMAPE+L D I+T SDV
Sbjct: 624 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 683
Query: 1176 WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRL 1235
WSFGV+LWEI TL PY G+ E++ K + +G +++ C +L +M CW P
Sbjct: 684 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 743
Query: 1236 RPSFTHILDSI---------QEELRPSFRLLSFYYSPECRGARGSLPTT--DAEPDSSPT 1284
RP+F +++ + QE L S L YSP R S ++ D+ P
Sbjct: 744 RPTFKQLVEDLDRIVALTSNQEYLDLSMPL--DQYSPSFPDTRSSTCSSGEDSVFSHEPL 801
Query: 1285 PRD-CSPQN 1292
P + C P++
Sbjct: 802 PEEPCLPRH 810
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 216 bits (549), Expect = 1e-55
Identities = 112/310 (36%), Positives = 181/310 (58%), Gaps = 11/310 (3%)
Query: 952 LYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTP 1009
L + P + S++ +P + WE+ R ++++ + LG+G FG V A G++ + P
Sbjct: 445 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 504
Query: 1010 V--ALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1066
V A+K + + A+ ++ + + E +MK H +++ LLG +QG P V++E +G+
Sbjct: 505 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 564
Query: 1067 LKSHLRSLRPEAEN------NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARN 1120
L+ LR+ RP + P Q +++ A ++A GM YLA+ K +HRDLAARN
Sbjct: 565 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 624
Query: 1121 CMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGV 1180
+V++D +KI DFG+ RDV+ DYY+K G LPV+WMAPE+L D ++T SDVWSFGV
Sbjct: 625 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 684
Query: 1181 VLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240
+LWEI TL PY G+ E++ K + +G +++ C L +M CW P RP+F
Sbjct: 685 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 744
Query: 1241 HILDSIQEEL 1250
+++ + L
Sbjct: 745 QLVEDLDRVL 754
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 216 bits (549), Expect = 1e-55
Identities = 112/310 (36%), Positives = 181/310 (58%), Gaps = 11/310 (3%)
Query: 952 LYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTP 1009
L + P + S++ +P + WE+ R ++++ + LG+G FG V A G++ + P
Sbjct: 331 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 390
Query: 1010 V--ALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1066
V A+K + + A+ ++ + + E +MK H +++ LLG +QG P V++E +G+
Sbjct: 391 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 450
Query: 1067 LKSHLRSLRPEAEN------NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARN 1120
L+ LR+ RP + P Q +++ A ++A GM YLA+ K +HRDLAARN
Sbjct: 451 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 510
Query: 1121 CMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGV 1180
+V++D +KI DFG+ RDV+ DYY+K G LPV+WMAPE+L D ++T SDVWSFGV
Sbjct: 511 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 570
Query: 1181 VLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240
+LWEI TL PY G+ E++ K + +G +++ C L +M CW P RP+F
Sbjct: 571 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 630
Query: 1241 HILDSIQEEL 1250
+++ + L
Sbjct: 631 QLVEDLDRVL 640
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 216 bits (549), Expect = 1e-55
Identities = 112/310 (36%), Positives = 181/310 (58%), Gaps = 11/310 (3%)
Query: 952 LYASVNPEYFSASDMYVPDE--WEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTP 1009
L + P + S++ +P + WE+ R ++++ + LG+G FG V A G++ + P
Sbjct: 443 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 502
Query: 1010 V--ALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1066
V A+K + + A+ ++ + + E +MK H +++ LLG +QG P V++E +G+
Sbjct: 503 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 562
Query: 1067 LKSHLRSLRPEAEN------NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARN 1120
L+ LR+ RP + P Q +++ A ++A GM YLA+ K +HRDLAARN
Sbjct: 563 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 622
Query: 1121 CMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGV 1180
+V++D +KI DFG+ RDV+ DYY+K G LPV+WMAPE+L D ++T SDVWSFGV
Sbjct: 623 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 682
Query: 1181 VLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240
+LWEI TL PY G+ E++ K + +G +++ C L +M CW P RP+F
Sbjct: 683 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 742
Query: 1241 HILDSIQEEL 1250
+++ + L
Sbjct: 743 QLVEDLDRVL 752
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,853,606
Number of Sequences: 37866
Number of extensions: 2776422
Number of successful extensions: 9959
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 491
Number of HSP's successfully gapped in prelim test: 423
Number of HSP's that attempted gapping in prelim test: 6942
Number of HSP's gapped (non-prelim): 2105
length of query: 1297
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1183
effective length of database: 13,930,794
effective search space: 16480129302
effective search space used: 16480129302
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.