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Search of human proteins with 31377782
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31377782 protein kinase C, delta [Homo sapiens]
(676 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47157325 protein kinase C, delta [Homo sapiens] 1397 0.0
gi|31377782 protein kinase C, delta [Homo sapiens] 1397 0.0
gi|5453976 protein kinase C, theta [Homo sapiens] 907 0.0
gi|4885563 protein kinase C, epsilon [Homo sapiens] 569 e-162
gi|28557781 protein kinase C, eta [Homo sapiens] 556 e-158
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 392 e-109
gi|4506067 protein kinase C, alpha [Homo sapiens] 375 e-104
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 375 e-104
gi|13384594 protein kinase C, gamma [Homo sapiens] 362 e-100
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 343 3e-94
gi|133908623 protein kinase C, iota [Homo sapiens] 341 1e-93
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 318 1e-86
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 318 1e-86
gi|5453974 protein kinase N2 [Homo sapiens] 311 2e-84
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 310 4e-84
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 310 4e-84
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 293 3e-79
gi|40254851 protein kinase PKNbeta [Homo sapiens] 291 1e-78
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 290 2e-78
gi|4502023 AKT2 kinase [Homo sapiens] 287 2e-77
gi|62241015 AKT1 kinase [Homo sapiens] 284 2e-76
gi|62241013 AKT1 kinase [Homo sapiens] 284 2e-76
gi|62241011 AKT1 kinase [Homo sapiens] 284 2e-76
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 271 1e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 271 1e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 271 1e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 271 1e-72
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 269 7e-72
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 269 7e-72
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 266 5e-71
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 1397 bits (3615), Expect = 0.0
Identities = 676/676 (100%), Positives = 676/676 (100%)
Query: 1 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
Sbjct: 1 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
Query: 61 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
Sbjct: 61 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
Query: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
Sbjct: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
Query: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
Sbjct: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
Query: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
Sbjct: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
Query: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
Sbjct: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
Query: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
Sbjct: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
Query: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
Query: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
Sbjct: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
Query: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
Sbjct: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
Query: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
Sbjct: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
Query: 661 AGFSFVNPKFEHLLED 676
AGFSFVNPKFEHLLED
Sbjct: 661 AGFSFVNPKFEHLLED 676
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 1397 bits (3615), Expect = 0.0
Identities = 676/676 (100%), Positives = 676/676 (100%)
Query: 1 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
Sbjct: 1 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
Query: 61 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
Sbjct: 61 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
Query: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
Sbjct: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
Query: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
Sbjct: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
Query: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
Sbjct: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
Query: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
Sbjct: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
Query: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
Sbjct: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
Query: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
Query: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
Sbjct: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
Query: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
Sbjct: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
Query: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
Sbjct: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
Query: 661 AGFSFVNPKFEHLLED 676
AGFSFVNPKFEHLLED
Sbjct: 661 AGFSFVNPKFEHLLED 676
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 907 bits (2344), Expect = 0.0
Identities = 443/705 (62%), Positives = 537/705 (76%), Gaps = 31/705 (4%)
Query: 1 MAPFLRIAFNSYELGSLQA-EDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTF 59
M+PFLRI ++++ GS Q+ + EA P+CAV +KE + +E G+ +QKKPTMYP W STF
Sbjct: 1 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60
Query: 60 DAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQ 119
DAHI +GRV+QI++ + +SE TV + LAERC+KNNGK E WL+L+PQ ++LM+ +
Sbjct: 61 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120
Query: 120 YFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFV 179
YFLE D K E E F RRGAIKQAK+H++K HEF ATFF QPTFCSVC +FV
Sbjct: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180
Query: 180 WGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYM 239
WGLNKQGY+CRQCNAAIHKKCIDK+I +CTG+A NSR+T+F KERF IDMPHRFKV+NY
Sbjct: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240
Query: 240 SPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV--TQR 297
SPTFC+HCG+LLWGL +QGLKC+ CGMNVHH+C+ KVANLCGINQKL+AEAL + TQ+
Sbjct: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300
Query: 298 ASRRSDSAS---SEPVGI----------------YQGFEKKTGVAGEDMQDNSGTYGKIW 338
A D+ PV I G + G++ E D +
Sbjct: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360
Query: 339 EGSS---------KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDD 389
E K I +FI HK+LGKGSFGKV L E K ++FAIKALKKDVVL+DD
Sbjct: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
Query: 390 DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYR 449
DVECTMVEKRVL+LA E+PFLTH+ CTFQTK++LFFVME+LNGGDLMYHIQ +F+L R
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
Query: 450 ATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFC 509
ATFYAAEI+ GLQFLHSKGI+YRDLKLDN+LLD+DGHIKIADFGMCKEN+ G+++ +TFC
Sbjct: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
Query: 510 GTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPR 569
GTPDYIAPEIL G KY SVDWWSFGVLLYEMLIGQSPFHG DE+ELF SIR+D P YPR
Sbjct: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
Query: 570 WITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD 629
W+ KE+KD+L KLF REP KRLGV G+I+ HP F+ INW LE++ ++PPFRPKVKSP D
Sbjct: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660
Query: 630 YSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLL 674
SNFD+EFLNEK RLS++D+ LI+SMDQ+ F FSF+NP E L+
Sbjct: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLI 705
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 569 bits (1467), Expect = e-162
Identities = 287/681 (42%), Positives = 413/681 (60%), Gaps = 58/681 (8%)
Query: 41 GKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNG 100
G+T ++K T P W F + GR I++ + A + ++ E +N
Sbjct: 52 GQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGS 110
Query: 101 KA-EFWLDLQPQAKVLMSVQYFLEDVDC-KQSMRSEDEAKFPTMNRRGAIKQAKIHYIKN 158
+ E W+DL+P+ +V + + + K + + R+GA+++ ++H +
Sbjct: 111 RHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRR-RVHQVNG 169
Query: 159 HEFIATFFGQPTFCSVCKDFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRD 217
H+F+AT+ QPT+CS C+DF+WG + KQGY+C+ C +HK+C + II +C G
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
Query: 218 TIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277
+RF+++MPH+F +HNY PTFCDHCGSLLWGL++QGL+C+ C MNVH +C VA
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVA 289
Query: 278 NLCGINQKLLAEAL-------NQVTQRASRRS--------------------DSASSEPV 310
CG++ + +A+ L +++T RR D + S P
Sbjct: 290 PNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPT 349
Query: 311 GIY-------------------QGFEKKTGVAGEDMQDNSGTYGKIWEGSSK-CNINNFI 350
+G E + + + + G G++ +G +K ++ F
Sbjct: 350 SPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFN 409
Query: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
F KVLGKGSFGKV+L ELKG+ E +A+K LKKDV+L DDDV+CTM EKR+L LA ++P+L
Sbjct: 410 FIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYL 469
Query: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
T L C FQTKD LFFVME++NGGDLM+ IQ +F+ R+ FYAAE+ L FLH G+I
Sbjct: 470 TQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529
Query: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
YRDLKLDN+LLD +GH K+ADFGMCKE I +TFCGTPDYIAPEILQ L+Y SVD
Sbjct: 530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVD 589
Query: 531 WWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKR 590
WW+ GVL+YEM+ GQ PF D+ED+LFESI D YP W++KE+ IL+ + P KR
Sbjct: 590 WWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR 649
Query: 591 LGVTGN------IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
LG + IK HPFFK I+W LLE+++++PPF+P++K+ RD +NFDQ+F E+ L
Sbjct: 650 LGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVL 709
Query: 645 SYSDKNLIDSMDQSAFAGFSF 665
+ D+ ++ ++Q F GFS+
Sbjct: 710 TLVDEAIVKQINQEEFKGFSY 730
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 556 bits (1434), Expect = e-158
Identities = 282/635 (44%), Positives = 400/635 (62%), Gaps = 22/635 (3%)
Query: 47 KKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA---E 103
K+ T P + F A++ +G +++ + ++ + + G + E
Sbjct: 60 KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFE 119
Query: 104 FWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIA 163
W+DL+P+ KV + + L + +++ + K T R+ A+++ ++H I H+F+A
Sbjct: 120 GWVDLEPEGKVFVVIT--LTGSFTEATLQRDRIFKHFTRKRQRAMRR-RVHQINGHKFMA 176
Query: 164 TFFGQPTFCSVCKDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCT-GTAANSRDTIFQ 221
T+ QPT+CS C++F+WG+ KQGY+C+ C +HK+C I+ CT N D+
Sbjct: 177 TYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIA 236
Query: 222 KERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCG 281
++RF I++PH+F +HNY PTFCDHCGSLLWG+++QGL+C+ C MNVH +C+ VA CG
Sbjct: 237 EQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCG 296
Query: 282 INQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGS 341
+N LA+ L + + S ++ + K++ G + NS S
Sbjct: 297 VNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNS---------S 347
Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
++ I+NF F +VLGKGSFGKV+L +K G+ +A+K LKKDV+L DDDVECTM EKR+L
Sbjct: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
Query: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
+LA +PFLT L C FQT D LFFVMEF+NGGDLM+HIQ RF+ RA FYAAEI+ L
Sbjct: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
Query: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
FLH KGIIYRDLKLDNVLLD +GH K+ADFGMCKE I +TFCGTPDYIAPEILQ
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527
Query: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
+ Y +VDWW+ GVLLYEML G +PF ++ED+LFE+I D YP W+ +++ IL+
Sbjct: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587
Query: 582 LFEREPTKRLGVTGN-----IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
+ PT RLG I HPFFK I+W L R++EPPFRP++KS D SNFD +
Sbjct: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647
Query: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFE 671
F+ E+ L+ D+ + ++Q F FS+V+P+ +
Sbjct: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 392 bits (1008), Expect = e-109
Identities = 196/332 (59%), Positives = 241/332 (72%), Gaps = 4/332 (1%)
Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
+ + +F F VLGKGSFGKV+L E KG E +A+K LKKDVV+ DDDVECTMVEKRVL
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
L + PFLT L FQT D L+FVME++NGGDLMYHIQ GRF+ A FYAAEI GL
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+ TFCGTPDYIAPEI+
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
Y SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI YP+ ++KE+ I + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
+ P KRLG +IK H FF+ I+W LE++ ++PP++PK + RD SNFD+EF
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635
Query: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670
+ L+ +DK I ++DQ+ FAGFS+ NP+F
Sbjct: 636 RQPVELTPTDKLFIMNLDQNEFAGFSYTNPEF 667
Score = 158 bits (400), Expect = 1e-38
Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)
Query: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192
SE E R+GA++Q +H +KNH+F A FF QPTFCS C DF+WG KQG++C+ C
Sbjct: 11 SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70
Query: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252
+HK+C + + C G + + H+FK+H Y SPTFCDHCGSLL+
Sbjct: 71 CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123
Query: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281
GL+ QG+KC+ C MNVH +C V +LCG
Sbjct: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152
Score = 48.1 bits (113), Expect = 3e-05
Identities = 21/71 (29%), Positives = 33/71 (46%)
Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
H+F + PTFC C ++GL QG KC C +HK+C+ + C R
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161
Query: 219 IFQKERFNIDM 229
I+ + + D+
Sbjct: 162 IYIQAHIDRDV 172
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 375 bits (964), Expect = e-104
Identities = 198/364 (54%), Positives = 248/364 (68%), Gaps = 6/364 (1%)
Query: 314 QGFEK-KTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRG 372
Q FEK K G AG + S + + + +F F VLGKGSFGKV+L + KG
Sbjct: 303 QKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362
Query: 373 EYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432
E +AIK LKKDVV+ DDDVECTMVEKRVL L + PFLT L FQT D L+FVME++NG
Sbjct: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNG 422
Query: 433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADF 492
GDLMYHIQ G+F+ +A FYAAEI GL FLH +GIIYRDLKLDNV+LD +GHIKIADF
Sbjct: 423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADF 482
Query: 493 GMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDD 552
GMCKE++ TFCGTPDYIAPEI+ Y SVDWW++GVLLYEML GQ PF G+D
Sbjct: 483 GMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 542
Query: 553 EDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV----TGNIKIHPFFKTINW 608
EDELF+SI YP+ ++KE+ I + L + P KRLG +++ H FF+ I+W
Sbjct: 543 EDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDW 602
Query: 609 TLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
LE R ++PPF+PKV + NFD+ F + L+ D+ +I ++DQS F GFS+VNP
Sbjct: 603 EKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
Query: 669 KFEH 672
+F H
Sbjct: 662 QFVH 665
Score = 159 bits (403), Expect = 6e-39
Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 7/140 (5%)
Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
R+GA++Q +H +K+H+FIA FF QPTFCS C DF+WG KQG++C+ C +HK+C +
Sbjct: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
Query: 204 IIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCED 263
+ C G A DT + + H+FK+H Y SPTFCDHCGSLL+GL+ QG+KC+
Sbjct: 82 VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134
Query: 264 CGMNVHHKCREKVANLCGIN 283
C MNVH +C V +LCG++
Sbjct: 135 CDMNVHKQCVINVPSLCGMD 154
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/64 (34%), Positives = 32/64 (50%)
Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
H+F +G PTFC C ++GL QG KC C+ +HK+C+ + C R
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGR 161
Query: 219 IFQK 222
I+ K
Sbjct: 162 IYLK 165
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 375 bits (964), Expect = e-104
Identities = 193/332 (58%), Positives = 236/332 (71%), Gaps = 5/332 (1%)
Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
+ + +F F VLGKGSFGKV+L E KG E +A+K LKKDVV+ DDDVECTMVEKRVL
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
L + PFLT L FQT D L+FVME++NGGDLMYHIQ GRF+ A FYAAEI GL
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+ TFCGTPDYIAPEI+
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
Y SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI YP+ ++KE+ I + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
+ P KRLG +IK H FF+ I+W LE++ ++PP++PK R+ NFD+ F
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFT 634
Query: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670
L+ D+ +I ++DQS F GFSFVN +F
Sbjct: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEF 666
Score = 158 bits (400), Expect = 1e-38
Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)
Query: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192
SE E R+GA++Q +H +KNH+F A FF QPTFCS C DF+WG KQG++C+ C
Sbjct: 11 SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70
Query: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252
+HK+C + + C G + + H+FK+H Y SPTFCDHCGSLL+
Sbjct: 71 CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123
Query: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281
GL+ QG+KC+ C MNVH +C V +LCG
Sbjct: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152
Score = 48.1 bits (113), Expect = 3e-05
Identities = 21/71 (29%), Positives = 33/71 (46%)
Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
H+F + PTFC C ++GL QG KC C +HK+C+ + C R
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161
Query: 219 IFQKERFNIDM 229
I+ + + D+
Sbjct: 162 IYIQAHIDRDV 172
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 362 bits (928), Expect = e-100
Identities = 185/339 (54%), Positives = 234/339 (69%), Gaps = 10/339 (2%)
Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
+ +I++F F VLGKGSFGKV+L E +G E +AIK LKKDV++ DDDV+CT+VEKRVL
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
Query: 403 LAAENP-----FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEI 457
L P FLT L TFQT D L+FVME++ GGDLMYHIQ G+F+ A FYAAEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
Query: 458 MCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAP 517
GL FLH++GIIYRDLKLDNV+LD +GHIKI DFGMCKEN+F + TFCGTPDYIAP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
Query: 518 EILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKD 577
EI+ Y SVDWWSFGVLLYEML GQ PF G+DE+ELF++I T YP+ +++E+
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
Query: 578 ILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNF 633
I + + P KRLG I+ H FF+ I+W LE+ + PPFRP+ R NF
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643
Query: 634 DQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEH 672
D+ F L+ D+ ++ S+DQ+ F GF++VNP F H
Sbjct: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH 682
Score = 157 bits (396), Expect = 4e-38
Identities = 67/144 (46%), Positives = 96/144 (66%), Gaps = 7/144 (4%)
Query: 140 PTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKK 199
P R+GA++Q +H +K+H+F A FF QPTFCS C DF+WG+ KQG +C+ C+ +H++
Sbjct: 17 PLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRR 76
Query: 200 CIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGL 259
C + + C G A T + + H+F++H+Y SPTFCDHCGSLL+GLV QG+
Sbjct: 77 CHEFVTFECPG-AGKGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGM 129
Query: 260 KCEDCGMNVHHKCREKVANLCGIN 283
KC C MNVH +C V +LCG++
Sbjct: 130 KCSCCEMNVHRRCVRSVPSLCGVD 153
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 343 bits (880), Expect = 3e-94
Identities = 185/456 (40%), Positives = 268/456 (58%), Gaps = 21/456 (4%)
Query: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
H F+ + +C C +WGL +QG +C +C + VH +C V C + + +
Sbjct: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190
Query: 291 LNQVTQRASRRSDSASSEPVGI-YQGFEKKTGVAGEDMQDNS----GTYG-KIWEGSSKC 344
+ +D S E GI Y +K +D +D G G KI +G
Sbjct: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQG---L 247
Query: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA 404
+ +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V A
Sbjct: 248 GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
Query: 405 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL 464
+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI L FL
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
Query: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
H +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL+G +
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
Query: 525 YTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITKESKD 577
Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++ ++
Sbjct: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
Query: 578 ILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSN 632
+L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++ N
Sbjct: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
Query: 633 FDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
FD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
Score = 57.4 bits (137), Expect = 4e-08
Identities = 22/57 (38%), Positives = 33/57 (57%)
Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKC 200
RRGA + K++ H F A F + +C C + +WGL +QGY+C C +HK+C
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRC 172
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 341 bits (874), Expect = 1e-93
Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)
Query: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
H F+ + C C +WGL +QG KC +C + VH KC + V CG L E
Sbjct: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199
Query: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350
+ + Q +S SD A + E V E N+ GK SS + +F
Sbjct: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255
Query: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
+V+G+GS+ KVLL LK +A+K +KK++V D+D++ EK V A+ +PFL
Sbjct: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315
Query: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
L FQT+ LFFV+E++NGGDLM+H+Q + + A FY+AEI L +LH +GII
Sbjct: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375
Query: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
YRDLKLDNVLLD +GHIK+ D+GMCKE + STFCGTP+YIAPEIL+G Y FSVD
Sbjct: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435
Query: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
WW+ GVL++EM+ G+SPF + ED LF+ I PR ++ ++ +L+
Sbjct: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495
Query: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
++P +RLG TG +I+ HPFF+ ++W ++E++++ PPF+P + NFD +
Sbjct: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555
Query: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
F NE +L+ D +++ +DQS F GF ++NP
Sbjct: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
Score = 63.5 bits (153), Expect = 6e-10
Identities = 26/65 (40%), Positives = 36/65 (55%)
Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
RRGA + K++ H F A F + C++C D +WGL +QGYKC C +HKKC
Sbjct: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
Query: 204 IIGRC 208
+ C
Sbjct: 186 VTIEC 190
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 318 bits (815), Expect = 1e-86
Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)
Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
S + +F F VLG+G FGKVLL E + GE FAIKALKK ++ D+VE M EKR+L
Sbjct: 614 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673
Query: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
+A +PFL +L FQT +H+ FVME+ GGDLM HI F RA FY+A ++
Sbjct: 674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 732
Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
GLQFLH I+YRDLKLDN+LLD +G++KIADFG+CKE + R STFCGTP+++APE+
Sbjct: 733 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 792
Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
L YT +VDWW GVLLYEML+G+SPF GDDE+E+F+SI D YPR+++ E+ I+
Sbjct: 793 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 852
Query: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
+L R P +RLG + ++K PFF+T+ W L RRL PPF P + D SNFD+
Sbjct: 853 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912
Query: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
EF E LS D + + +Q+AF F FV
Sbjct: 913 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 318 bits (815), Expect = 1e-86
Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)
Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
S + +F F VLG+G FGKVLL E + GE FAIKALKK ++ D+VE M EKR+L
Sbjct: 608 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 667
Query: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
+A +PFL +L FQT +H+ FVME+ GGDLM HI F RA FY+A ++
Sbjct: 668 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 726
Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
GLQFLH I+YRDLKLDN+LLD +G++KIADFG+CKE + R STFCGTP+++APE+
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
L YT +VDWW GVLLYEML+G+SPF GDDE+E+F+SI D YPR+++ E+ I+
Sbjct: 787 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 846
Query: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
+L R P +RLG + ++K PFF+T+ W L RRL PPF P + D SNFD+
Sbjct: 847 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 906
Query: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
EF E LS D + + +Q+AF F FV
Sbjct: 907 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 311 bits (796), Expect = 2e-84
Identities = 156/329 (47%), Positives = 217/329 (65%), Gaps = 8/329 (2%)
Query: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTL- 403
N+ +F VLG+G FGKVLL E K E FAIKALKK ++ D+V+ M EKR+
Sbjct: 653 NLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 712
Query: 404 -AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
+ +PFL +L FQTK+H+ FVME+ GGDLM HI F RA FYAA ++ GLQ
Sbjct: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQ 771
Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
+LH I+YRDLKLDN+LLD +G +KIADFG+CKE + R STFCGTP+++APE+L
Sbjct: 772 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 831
Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
YT +VDWW GVL+YEML+G+SPF GDDE+E+F+SI D YPR+++ E+ I+ +L
Sbjct: 832 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 891
Query: 583 FEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
R P +RLG + ++K HPFF+ I+W+ L ++++PPF P ++ D SNFD EF
Sbjct: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951
Query: 639 NEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
+E L+ + ++ +Q F F ++
Sbjct: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 310 bits (793), Expect = 4e-84
Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)
Query: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
S + +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
A+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
+G +Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
++ +L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
NFD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 310 bits (793), Expect = 4e-84
Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)
Query: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
S + +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
A+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
+G +Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
++ +L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
NFD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 293 bits (751), Expect = 3e-79
Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 11/337 (3%)
Query: 324 GEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKD 383
GE+ D S T+ K + +N+F + K+LGKG+FGKV+L K G+Y+A+K LKK+
Sbjct: 129 GEEEMDASTTHHK------RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKE 182
Query: 384 VVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKG 443
V++ D+V T+ E RVL +PFLT L +FQTKD L FVME++NGG+L +H+ +
Sbjct: 183 VIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241
Query: 444 RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGES 503
F R FY AEI+ L +LHS I+YRDLKL+N++LD+DGHIKI DFG+CKE I +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301
Query: 504 RASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD 563
TFCGTP+Y+APE+L+ Y +VDWW GV++YEM+ G+ PF+ D ++LFE I ++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 361
Query: 564 TPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPP 619
+PR ++ ++K +L L ++P KRLG I H FF +NW + ++L PP
Sbjct: 362 DIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
Query: 620 FRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMD 656
F+P+V S D FD+EF + ++ +K D MD
Sbjct: 422 FKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMD 458
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 291 bits (745), Expect = 1e-78
Identities = 157/325 (48%), Positives = 208/325 (64%), Gaps = 10/325 (3%)
Query: 354 VLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA--ENPFLT 411
VLG+G FGKVLL + KG G+Y+AIKALKK VL D++E EKR+L +PFL
Sbjct: 564 VLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLL 623
Query: 412 HLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIY 471
L+ FQT H FV EF+ GGDLM I + F +A FY A ++ GLQFLH K IIY
Sbjct: 624 SLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FPEPQARFYVACVVLGLQFLHEKKIIY 682
Query: 472 RDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDW 531
RDLKLDN+LLD G +KIADFG+CKE I R STFCGTP+++APE+L YT +VDW
Sbjct: 683 RDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDW 742
Query: 532 WSFGVLLYEMLIGQSPFHGDDEDELFESI-RVDTPHYPRWITKESKDILEKLFEREPTKR 590
W GVLLYEML+G+ PF GD E+E+F+ I +D P YP +++ + + ++KL ++ P KR
Sbjct: 743 WGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQKLLQKCPEKR 801
Query: 591 LGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLS- 645
LG IK+ PFF+T NW L R ++PPF P + P D F+ EF L+
Sbjct: 802 LGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTP 861
Query: 646 YSDKNLIDSMDQSAFAGFSFVNPKF 670
+ +L+ + Q+AF F FV+ +F
Sbjct: 862 PAPHSLLTARQQAAFRDFDFVSERF 886
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 290 bits (743), Expect = 2e-78
Identities = 146/330 (44%), Positives = 213/330 (64%), Gaps = 11/330 (3%)
Query: 324 GEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKD 383
GE+ D S T+ K + +N+F + K+LGKG+FGKV+L K G+Y+A+K LKK+
Sbjct: 129 GEEEMDASTTHHK------RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKE 182
Query: 384 VVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKG 443
V++ D+V T+ E RVL +PFLT L +FQTKD L FVME++NGG+L +H+ +
Sbjct: 183 VIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241
Query: 444 RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGES 503
F R FY AEI+ L +LHS I+YRDLKL+N++LD+DGHIKI DFG+CKE I +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301
Query: 504 RASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD 563
TFCGTP+Y+APE+L+ Y +VDWW GV++YEM+ G+ PF+ D ++LFE I ++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 361
Query: 564 TPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPP 619
+PR ++ ++K +L L ++P KRLG I H FF +NW + ++L PP
Sbjct: 362 DIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
Query: 620 FRPKVKSPRDYSNFDQEFLNEKARLSYSDK 649
F+P+V S D FD+EF + ++ +K
Sbjct: 422 FKPQVTSETDTRYFDEEFTAQTITITPPEK 451
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 287 bits (735), Expect = 2e-77
Identities = 142/332 (42%), Positives = 214/332 (64%), Gaps = 9/332 (2%)
Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
+K +N+F + K+LGKG+FGKV+L K G Y+A+K L+K+V++ D+V T+ E RVL
Sbjct: 145 AKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL 204
Query: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
+PFLT L FQT D L FVME+ NGG+L +H+ + F RA FY AEI+ L
Sbjct: 205 Q-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
Query: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
++LHS+ ++YRD+KL+N++LD+DGHIKI DFG+CKE I + TFCGTP+Y+APE+L+
Sbjct: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323
Query: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
Y +VDWW GV++YEM+ G+ PF+ D + LFE I ++ +PR ++ E+K +L
Sbjct: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 383
Query: 582 LFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEF 637
L +++P +RLG + H FF +INW + +++L PPF+P+V S D FD EF
Sbjct: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443
Query: 638 LNEKARLS----YSDKNLIDSMDQSAFAGFSF 665
+ ++ Y L++ ++ F FS+
Sbjct: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (727), Expect = 2e-76
Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)
Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
G+ + E++ DNSG + + + +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
K G Y+A+K LKK+V++ D+V T+ E RVL + +PFLT L +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227
Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
E+ NGG+L +H+ + F RA FY AEI+ L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
IKI DFG+CKE I + TFCGTP+Y+APE+L+ Y +VDWW GV++YEM+ G+
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
PF+ D ++LFE I ++ +PR + E+K +L L +++P +RLG I H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
F I W + +++L PPF+P+V S D FD+EF + ++ D++ +DS +
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467
Query: 659 AFAGFSF 665
F FS+
Sbjct: 468 HFPQFSY 474
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (727), Expect = 2e-76
Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)
Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
G+ + E++ DNSG + + + +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
K G Y+A+K LKK+V++ D+V T+ E RVL + +PFLT L +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227
Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
E+ NGG+L +H+ + F RA FY AEI+ L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
IKI DFG+CKE I + TFCGTP+Y+APE+L+ Y +VDWW GV++YEM+ G+
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
PF+ D ++LFE I ++ +PR + E+K +L L +++P +RLG I H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
F I W + +++L PPF+P+V S D FD+EF + ++ D++ +DS +
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467
Query: 659 AFAGFSF 665
F FS+
Sbjct: 468 HFPQFSY 474
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (727), Expect = 2e-76
Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)
Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
G+ + E++ DNSG + + + +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
K G Y+A+K LKK+V++ D+V T+ E RVL + +PFLT L +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227
Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
E+ NGG+L +H+ + F RA FY AEI+ L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
IKI DFG+CKE I + TFCGTP+Y+APE+L+ Y +VDWW GV++YEM+ G+
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
PF+ D ++LFE I ++ +PR + E+K +L L +++P +RLG I H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
F I W + +++L PPF+P+V S D FD+EF + ++ D++ +DS +
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467
Query: 659 AFAGFSF 665
F FS+
Sbjct: 468 HFPQFSY 474
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 271 bits (693), Expect = 1e-72
Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)
Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
++F F KV+GKGSFGKVLL K ++A+K L+K +L + + M E+ VL +
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155
Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
+PFL L +FQT D L+FV++++NGG+L YH+Q + F RA FYAAEI L +LHS
Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215
Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
I+YRDLK +N+LLD GHI + DFG+CKENI S STFCGTP+Y+APE+L Y
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 275
Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
+VDWW G +LYEML G PF+ + E++++I IT ++ +LE L +++
Sbjct: 276 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 335
Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
TKRLG + IK H FF INW L +++ PPF P V P D +FD EF E
Sbjct: 336 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 395
Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
S D L+ + + AF GFS+ P
Sbjct: 396 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 271 bits (693), Expect = 1e-72
Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)
Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
++F F KV+GKGSFGKVLL K ++A+K L+K +L + + M E+ VL +
Sbjct: 110 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 169
Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
+PFL L +FQT D L+FV++++NGG+L YH+Q + F RA FYAAEI L +LHS
Sbjct: 170 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 229
Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
I+YRDLK +N+LLD GHI + DFG+CKENI S STFCGTP+Y+APE+L Y
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 289
Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
+VDWW G +LYEML G PF+ + E++++I IT ++ +LE L +++
Sbjct: 290 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 349
Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
TKRLG + IK H FF INW L +++ PPF P V P D +FD EF E
Sbjct: 350 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 409
Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
S D L+ + + AF GFS+ P
Sbjct: 410 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 271 bits (693), Expect = 1e-72
Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)
Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
++F F KV+GKGSFGKVLL K ++A+K L+K +L + + M E+ VL +
Sbjct: 124 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 183
Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
+PFL L +FQT D L+FV++++NGG+L YH+Q + F RA FYAAEI L +LHS
Sbjct: 184 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 243
Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
I+YRDLK +N+LLD GHI + DFG+CKENI S STFCGTP+Y+APE+L Y
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 303
Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
+VDWW G +LYEML G PF+ + E++++I IT ++ +LE L +++
Sbjct: 304 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 363
Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
TKRLG + IK H FF INW L +++ PPF P V P D +FD EF E
Sbjct: 364 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 423
Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
S D L+ + + AF GFS+ P
Sbjct: 424 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 271 bits (693), Expect = 1e-72
Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)
Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
++F F KV+GKGSFGKVLL K ++A+K L+K +L + + M E+ VL +
Sbjct: 191 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 250
Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
+PFL L +FQT D L+FV++++NGG+L YH+Q + F RA FYAAEI L +LHS
Sbjct: 251 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 310
Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
I+YRDLK +N+LLD GHI + DFG+CKENI S STFCGTP+Y+APE+L Y
Sbjct: 311 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 370
Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
+VDWW G +LYEML G PF+ + E++++I IT ++ +LE L +++
Sbjct: 371 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 430
Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
TKRLG + IK H FF INW L +++ PPF P V P D +FD EF E
Sbjct: 431 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 490
Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
S D L+ + + AF GFS+ P
Sbjct: 491 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 269 bits (687), Expect = 7e-72
Identities = 142/334 (42%), Positives = 200/334 (59%), Gaps = 7/334 (2%)
Query: 348 NFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAEN 407
+F F KV+GKG++GKVLL + K G ++A+K L+K +L + M E+ VL +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 408 PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSK 467
PFL L +FQT + L+FV++++NGG+L +H+Q + RF RA FYAAE+ + +LHS
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 468 GIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF 527
IIYRDLK +N+LLD GH+ + DFG+CKE + E STFCGTP+Y+APE+L+ Y
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREP 587
+VDWW G +LYEML G PF+ D +++E+I P T + D+L+ L ++
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273
Query: 588 TKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
+RLG + IK H FF INW L +RL PPF P V P D +FD EF E
Sbjct: 274 RQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSK 333
Query: 645 SYS---DKNLIDSMDQSAFAGFSFVNPKFEHLLE 675
S D S SAF GFS+ P+ + +L+
Sbjct: 334 SIGCTPDTVASSSGASSAFLGFSYA-PEDDDILD 366
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 269 bits (687), Expect = 7e-72
Identities = 142/334 (42%), Positives = 200/334 (59%), Gaps = 7/334 (2%)
Query: 348 NFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAEN 407
+F F KV+GKG++GKVLL + K G ++A+K L+K +L + M E+ VL +
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 408 PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSK 467
PFL L +FQT + L+FV++++NGG+L +H+Q + RF RA FYAAE+ + +LHS
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
Query: 468 GIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF 527
IIYRDLK +N+LLD GH+ + DFG+CKE + E STFCGTP+Y+APE+L+ Y
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
Query: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREP 587
+VDWW G +LYEML G PF+ D +++E+I P T + D+L+ L ++
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 333
Query: 588 TKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
+RLG + IK H FF INW L +RL PPF P V P D +FD EF E
Sbjct: 334 RQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSK 393
Query: 645 SYS---DKNLIDSMDQSAFAGFSFVNPKFEHLLE 675
S D S SAF GFS+ P+ + +L+
Sbjct: 394 SIGCTPDTVASSSGASSAFLGFSYA-PEDDDILD 426
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 266 bits (680), Expect = 5e-71
Identities = 139/338 (41%), Positives = 207/338 (61%), Gaps = 9/338 (2%)
Query: 340 GSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKR 399
G+ +F F KV+GKGSFGKVLL + K G+++A+K L+K +VL + + M E+
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERN 212
Query: 400 VLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
VL ++PFL L +FQT + L+FV++F+NGG+L +H+Q + F +RA FYAAEI
Sbjct: 213 VLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIAS 272
Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
L +LHS I+YRDLK +N+LLD GH+ + DFG+CKE I +TFCGTP+Y+APE+
Sbjct: 273 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEV 332
Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
++ Y +VDWW G +LYEML G PF+ D E++++I ++ + IL
Sbjct: 333 IRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 392
Query: 580 EKLFEREPTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
E+L E++ RLG + I+ HPFF++++W L ++++ PPF P V P D NFD
Sbjct: 393 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 452
Query: 637 FLNEKARLSY---SDKNLIDSM---DQSAFAGFSFVNP 668
F E S SD +++++ AF GFS+ P
Sbjct: 453 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,539,848
Number of Sequences: 37866
Number of extensions: 1153712
Number of successful extensions: 5561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 768
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3006
Number of HSP's gapped (non-prelim): 1223
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.