Guide to the Human Genome
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Search of human proteins with 31377782

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31377782 protein kinase C, delta [Homo sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47157325 protein kinase C, delta [Homo sapiens]                   1397   0.0  
gi|31377782 protein kinase C, delta [Homo sapiens]                   1397   0.0  
gi|5453976 protein kinase C, theta [Homo sapiens]                     907   0.0  
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   569   e-162
gi|28557781 protein kinase C, eta [Homo sapiens]                      556   e-158
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           392   e-109
gi|4506067 protein kinase C, alpha [Homo sapiens]                     375   e-104
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           375   e-104
gi|13384594 protein kinase C, gamma [Homo sapiens]                    362   e-100
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           343   3e-94
gi|133908623 protein kinase C, iota [Homo sapiens]                    341   1e-93
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                318   1e-86
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                318   1e-86
gi|5453974 protein kinase N2 [Homo sapiens]                           311   2e-84
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           310   4e-84
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           310   4e-84
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       293   3e-79
gi|40254851 protein kinase PKNbeta [Homo sapiens]                     291   1e-78
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      290   2e-78
gi|4502023 AKT2 kinase [Homo sapiens]                                 287   2e-77
gi|62241015 AKT1 kinase [Homo sapiens]                                284   2e-76
gi|62241013 AKT1 kinase [Homo sapiens]                                284   2e-76
gi|62241011 AKT1 kinase [Homo sapiens]                                284   2e-76
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   271   1e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   271   1e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   271   1e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   271   1e-72
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   269   7e-72
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   269   7e-72
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   266   5e-71

>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 1397 bits (3615), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
           MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
Sbjct: 1   MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60

Query: 61  AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
           AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
Sbjct: 61  AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120

Query: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
           FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
Sbjct: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180

Query: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
           GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
Sbjct: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240

Query: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
           PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
Sbjct: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300

Query: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
           RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
Sbjct: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360

Query: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
           GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
Sbjct: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420

Query: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
           DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480

Query: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
           LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
Sbjct: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540

Query: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
           MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
Sbjct: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600

Query: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
           PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
Sbjct: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660

Query: 661 AGFSFVNPKFEHLLED 676
           AGFSFVNPKFEHLLED
Sbjct: 661 AGFSFVNPKFEHLLED 676


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 1397 bits (3615), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60
           MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
Sbjct: 1   MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 60

Query: 61  AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120
           AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
Sbjct: 61  AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 120

Query: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180
           FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
Sbjct: 121 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 180

Query: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240
           GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
Sbjct: 181 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 240

Query: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300
           PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
Sbjct: 241 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 300

Query: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360
           RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
Sbjct: 301 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 360

Query: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420
           GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
Sbjct: 361 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420

Query: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480
           DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480

Query: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540
           LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
Sbjct: 481 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 540

Query: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600
           MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
Sbjct: 541 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 600

Query: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660
           PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
Sbjct: 601 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 660

Query: 661 AGFSFVNPKFEHLLED 676
           AGFSFVNPKFEHLLED
Sbjct: 661 AGFSFVNPKFEHLLED 676


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  907 bits (2344), Expect = 0.0
 Identities = 443/705 (62%), Positives = 537/705 (76%), Gaps = 31/705 (4%)

Query: 1   MAPFLRIAFNSYELGSLQA-EDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTF 59
           M+PFLRI  ++++ GS Q+ + EA  P+CAV +KE + +E G+  +QKKPTMYP W STF
Sbjct: 1   MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60

Query: 60  DAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQ 119
           DAHI +GRV+QI++     + +SE TV +  LAERC+KNNGK E WL+L+PQ ++LM+ +
Sbjct: 61  DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120

Query: 120 YFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFV 179
           YFLE  D K     E E  F    RRGAIKQAK+H++K HEF ATFF QPTFCSVC +FV
Sbjct: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180

Query: 180 WGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYM 239
           WGLNKQGY+CRQCNAAIHKKCIDK+I +CTG+A NSR+T+F KERF IDMPHRFKV+NY 
Sbjct: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240

Query: 240 SPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV--TQR 297
           SPTFC+HCG+LLWGL +QGLKC+ CGMNVHH+C+ KVANLCGINQKL+AEAL  +  TQ+
Sbjct: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300

Query: 298 ASRRSDSAS---SEPVGI----------------YQGFEKKTGVAGEDMQDNSGTYGKIW 338
           A    D+       PV I                  G  +  G++ E   D       + 
Sbjct: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360

Query: 339 EGSS---------KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDD 389
           E            K  I +FI HK+LGKGSFGKV L E K   ++FAIKALKKDVVL+DD
Sbjct: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420

Query: 390 DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYR 449
           DVECTMVEKRVL+LA E+PFLTH+ CTFQTK++LFFVME+LNGGDLMYHIQ   +F+L R
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480

Query: 450 ATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFC 509
           ATFYAAEI+ GLQFLHSKGI+YRDLKLDN+LLD+DGHIKIADFGMCKEN+ G+++ +TFC
Sbjct: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540

Query: 510 GTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPR 569
           GTPDYIAPEIL G KY  SVDWWSFGVLLYEMLIGQSPFHG DE+ELF SIR+D P YPR
Sbjct: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600

Query: 570 WITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD 629
           W+ KE+KD+L KLF REP KRLGV G+I+ HP F+ INW  LE++ ++PPFRPKVKSP D
Sbjct: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660

Query: 630 YSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLL 674
            SNFD+EFLNEK RLS++D+ LI+SMDQ+ F  FSF+NP  E L+
Sbjct: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLI 705


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  569 bits (1467), Expect = e-162
 Identities = 287/681 (42%), Positives = 413/681 (60%), Gaps = 58/681 (8%)

Query: 41  GKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNG 100
           G+T  ++K T  P W   F   +  GR I++ +   A     +     ++  E   +N  
Sbjct: 52  GQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGS 110

Query: 101 KA-EFWLDLQPQAKVLMSVQYFLEDVDC-KQSMRSEDEAKFPTMNRRGAIKQAKIHYIKN 158
           +  E W+DL+P+ +V + +       +  K +       +     R+GA+++ ++H +  
Sbjct: 111 RHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRR-RVHQVNG 169

Query: 159 HEFIATFFGQPTFCSVCKDFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRD 217
           H+F+AT+  QPT+CS C+DF+WG + KQGY+C+ C   +HK+C + II +C G       
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229

Query: 218 TIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277
                +RF+++MPH+F +HNY  PTFCDHCGSLLWGL++QGL+C+ C MNVH +C   VA
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVA 289

Query: 278 NLCGINQKLLAEAL-------NQVTQRASRRS--------------------DSASSEPV 310
             CG++ + +A+ L       +++T    RR                     D + S P 
Sbjct: 290 PNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPT 349

Query: 311 GIY-------------------QGFEKKTGVAGEDMQDNSGTYGKIWEGSSK-CNINNFI 350
                                 +G E +   + +    + G  G++ +G +K   ++ F 
Sbjct: 350 SPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFN 409

Query: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
           F KVLGKGSFGKV+L ELKG+ E +A+K LKKDV+L DDDV+CTM EKR+L LA ++P+L
Sbjct: 410 FIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYL 469

Query: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
           T L C FQTKD LFFVME++NGGDLM+ IQ   +F+  R+ FYAAE+   L FLH  G+I
Sbjct: 470 TQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529

Query: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
           YRDLKLDN+LLD +GH K+ADFGMCKE I      +TFCGTPDYIAPEILQ L+Y  SVD
Sbjct: 530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVD 589

Query: 531 WWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKR 590
           WW+ GVL+YEM+ GQ PF  D+ED+LFESI  D   YP W++KE+  IL+    + P KR
Sbjct: 590 WWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR 649

Query: 591 LGVTGN------IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
           LG   +      IK HPFFK I+W LLE+++++PPF+P++K+ RD +NFDQ+F  E+  L
Sbjct: 650 LGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVL 709

Query: 645 SYSDKNLIDSMDQSAFAGFSF 665
           +  D+ ++  ++Q  F GFS+
Sbjct: 710 TLVDEAIVKQINQEEFKGFSY 730


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  556 bits (1434), Expect = e-158
 Identities = 282/635 (44%), Positives = 400/635 (62%), Gaps = 22/635 (3%)

Query: 47  KKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA---E 103
           K+ T  P +   F A++ +G  +++ +               ++  +   +  G +   E
Sbjct: 60  KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFE 119

Query: 104 FWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIA 163
            W+DL+P+ KV + +   L     + +++ +   K  T  R+ A+++ ++H I  H+F+A
Sbjct: 120 GWVDLEPEGKVFVVIT--LTGSFTEATLQRDRIFKHFTRKRQRAMRR-RVHQINGHKFMA 176

Query: 164 TFFGQPTFCSVCKDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCT-GTAANSRDTIFQ 221
           T+  QPT+CS C++F+WG+  KQGY+C+ C   +HK+C   I+  CT     N  D+   
Sbjct: 177 TYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIA 236

Query: 222 KERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCG 281
           ++RF I++PH+F +HNY  PTFCDHCGSLLWG+++QGL+C+ C MNVH +C+  VA  CG
Sbjct: 237 EQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCG 296

Query: 282 INQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGS 341
           +N   LA+ L  +  +    S ++        +   K++   G  +  NS         S
Sbjct: 297 VNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNS---------S 347

Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
           ++  I+NF F +VLGKGSFGKV+L  +K  G+ +A+K LKKDV+L DDDVECTM EKR+L
Sbjct: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407

Query: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
           +LA  +PFLT L C FQT D LFFVMEF+NGGDLM+HIQ   RF+  RA FYAAEI+  L
Sbjct: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467

Query: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
            FLH KGIIYRDLKLDNVLLD +GH K+ADFGMCKE I      +TFCGTPDYIAPEILQ
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527

Query: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
            + Y  +VDWW+ GVLLYEML G +PF  ++ED+LFE+I  D   YP W+ +++  IL+ 
Sbjct: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587

Query: 582 LFEREPTKRLGVTGN-----IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
              + PT RLG         I  HPFFK I+W  L  R++EPPFRP++KS  D SNFD +
Sbjct: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647

Query: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFE 671
           F+ E+  L+  D+  +  ++Q  F  FS+V+P+ +
Sbjct: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  392 bits (1008), Expect = e-109
 Identities = 196/332 (59%), Positives = 241/332 (72%), Gaps = 4/332 (1%)

Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
           +  + +F F  VLGKGSFGKV+L E KG  E +A+K LKKDVV+ DDDVECTMVEKRVL 
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395

Query: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
           L  + PFLT L   FQT D L+FVME++NGGDLMYHIQ  GRF+   A FYAAEI  GL 
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455

Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
           FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+      TFCGTPDYIAPEI+  
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515

Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
             Y  SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI      YP+ ++KE+  I + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
             + P KRLG       +IK H FF+ I+W  LE++ ++PP++PK +  RD SNFD+EF 
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635

Query: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670
            +   L+ +DK  I ++DQ+ FAGFS+ NP+F
Sbjct: 636 RQPVELTPTDKLFIMNLDQNEFAGFSYTNPEF 667



 Score =  158 bits (400), Expect = 1e-38
 Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)

Query: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192
           SE E       R+GA++Q  +H +KNH+F A FF QPTFCS C DF+WG  KQG++C+ C
Sbjct: 11  SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70

Query: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252
              +HK+C + +   C G          + +       H+FK+H Y SPTFCDHCGSLL+
Sbjct: 71  CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123

Query: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281
           GL+ QG+KC+ C MNVH +C   V +LCG
Sbjct: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 21/71 (29%), Positives = 33/71 (46%)

Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
           H+F    +  PTFC  C   ++GL  QG KC  C   +HK+C+  +   C       R  
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161

Query: 219 IFQKERFNIDM 229
           I+ +   + D+
Sbjct: 162 IYIQAHIDRDV 172


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  375 bits (964), Expect = e-104
 Identities = 198/364 (54%), Positives = 248/364 (68%), Gaps = 6/364 (1%)

Query: 314 QGFEK-KTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRG 372
           Q FEK K G AG  +   S    +      +  + +F F  VLGKGSFGKV+L + KG  
Sbjct: 303 QKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362

Query: 373 EYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432
           E +AIK LKKDVV+ DDDVECTMVEKRVL L  + PFLT L   FQT D L+FVME++NG
Sbjct: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNG 422

Query: 433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADF 492
           GDLMYHIQ  G+F+  +A FYAAEI  GL FLH +GIIYRDLKLDNV+LD +GHIKIADF
Sbjct: 423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADF 482

Query: 493 GMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDD 552
           GMCKE++       TFCGTPDYIAPEI+    Y  SVDWW++GVLLYEML GQ PF G+D
Sbjct: 483 GMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 542

Query: 553 EDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV----TGNIKIHPFFKTINW 608
           EDELF+SI      YP+ ++KE+  I + L  + P KRLG       +++ H FF+ I+W
Sbjct: 543 EDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDW 602

Query: 609 TLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
             LE R ++PPF+PKV   +   NFD+ F   +  L+  D+ +I ++DQS F GFS+VNP
Sbjct: 603 EKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661

Query: 669 KFEH 672
           +F H
Sbjct: 662 QFVH 665



 Score =  159 bits (403), Expect = 6e-39
 Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 7/140 (5%)

Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
           R+GA++Q  +H +K+H+FIA FF QPTFCS C DF+WG  KQG++C+ C   +HK+C + 
Sbjct: 22  RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81

Query: 204 IIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCED 263
           +   C G A    DT   + +      H+FK+H Y SPTFCDHCGSLL+GL+ QG+KC+ 
Sbjct: 82  VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134

Query: 264 CGMNVHHKCREKVANLCGIN 283
           C MNVH +C   V +LCG++
Sbjct: 135 CDMNVHKQCVINVPSLCGMD 154



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 22/64 (34%), Positives = 32/64 (50%)

Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
           H+F    +G PTFC  C   ++GL  QG KC  C+  +HK+C+  +   C       R  
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGR 161

Query: 219 IFQK 222
           I+ K
Sbjct: 162 IYLK 165


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  375 bits (964), Expect = e-104
 Identities = 193/332 (58%), Positives = 236/332 (71%), Gaps = 5/332 (1%)

Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
           +  + +F F  VLGKGSFGKV+L E KG  E +A+K LKKDVV+ DDDVECTMVEKRVL 
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395

Query: 403 LAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
           L  + PFLT L   FQT D L+FVME++NGGDLMYHIQ  GRF+   A FYAAEI  GL 
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455

Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
           FL SKGIIYRDLKLDNV+LD +GHIKIADFGMCKENI+      TFCGTPDYIAPEI+  
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515

Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
             Y  SVDWW+FGVLLYEML GQ+PF G+DEDELF+SI      YP+ ++KE+  I + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 583 FEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
             + P KRLG       +IK H FF+ I+W  LE++ ++PP++PK    R+  NFD+ F 
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFT 634

Query: 639 NEKARLSYSDKNLIDSMDQSAFAGFSFVNPKF 670
                L+  D+ +I ++DQS F GFSFVN +F
Sbjct: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEF 666



 Score =  158 bits (400), Expect = 1e-38
 Identities = 69/149 (46%), Positives = 93/149 (62%), Gaps = 7/149 (4%)

Query: 133 SEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQC 192
           SE E       R+GA++Q  +H +KNH+F A FF QPTFCS C DF+WG  KQG++C+ C
Sbjct: 11  SEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVC 70

Query: 193 NAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLW 252
              +HK+C + +   C G          + +       H+FK+H Y SPTFCDHCGSLL+
Sbjct: 71  CFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSSPTFCDHCGSLLY 123

Query: 253 GLVKQGLKCEDCGMNVHHKCREKVANLCG 281
           GL+ QG+KC+ C MNVH +C   V +LCG
Sbjct: 124 GLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 21/71 (29%), Positives = 33/71 (46%)

Query: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
           H+F    +  PTFC  C   ++GL  QG KC  C   +HK+C+  +   C       R  
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161

Query: 219 IFQKERFNIDM 229
           I+ +   + D+
Sbjct: 162 IYIQAHIDRDV 172


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  362 bits (928), Expect = e-100
 Identities = 185/339 (54%), Positives = 234/339 (69%), Gaps = 10/339 (2%)

Query: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
           + +I++F F  VLGKGSFGKV+L E +G  E +AIK LKKDV++ DDDV+CT+VEKRVL 
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 403 LAAENP-----FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEI 457
           L    P     FLT L  TFQT D L+FVME++ GGDLMYHIQ  G+F+   A FYAAEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 458 MCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAP 517
             GL FLH++GIIYRDLKLDNV+LD +GHIKI DFGMCKEN+F  +   TFCGTPDYIAP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524

Query: 518 EILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKD 577
           EI+    Y  SVDWWSFGVLLYEML GQ PF G+DE+ELF++I   T  YP+ +++E+  
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584

Query: 578 ILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNF 633
           I +    + P KRLG        I+ H FF+ I+W  LE+  + PPFRP+    R   NF
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643

Query: 634 DQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEH 672
           D+ F      L+  D+ ++ S+DQ+ F GF++VNP F H
Sbjct: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH 682



 Score =  157 bits (396), Expect = 4e-38
 Identities = 67/144 (46%), Positives = 96/144 (66%), Gaps = 7/144 (4%)

Query: 140 PTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKK 199
           P   R+GA++Q  +H +K+H+F A FF QPTFCS C DF+WG+ KQG +C+ C+  +H++
Sbjct: 17  PLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRR 76

Query: 200 CIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGL 259
           C + +   C G A     T   + +      H+F++H+Y SPTFCDHCGSLL+GLV QG+
Sbjct: 77  CHEFVTFECPG-AGKGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGM 129

Query: 260 KCEDCGMNVHHKCREKVANLCGIN 283
           KC  C MNVH +C   V +LCG++
Sbjct: 130 KCSCCEMNVHRRCVRSVPSLCGVD 153


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  343 bits (880), Expect = 3e-94
 Identities = 185/456 (40%), Positives = 268/456 (58%), Gaps = 21/456 (4%)

Query: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
           H F+   +    +C  C   +WGL +QG +C +C + VH +C   V   C  +   +  +
Sbjct: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190

Query: 291 LNQVTQRASRRSDSASSEPVGI-YQGFEKKTGVAGEDMQDNS----GTYG-KIWEGSSKC 344
                   +  +D  S E  GI Y    +K     +D +D      G  G KI +G    
Sbjct: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQG---L 247

Query: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA 404
            + +F   +V+G+GS+ KVLL  LK   + +A+K +KK++V  D+D++    EK V   A
Sbjct: 248 GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA 307

Query: 405 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL 464
           + NPFL  L   FQT   LF V+E++NGGDLM+H+Q + +     A FYAAEI   L FL
Sbjct: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367

Query: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
           H +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE +      STFCGTP+YIAPEIL+G +
Sbjct: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427

Query: 525 YTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITKESKD 577
           Y FSVDWW+ GVL++EM+ G+SPF         + ED LF+ I       PR+++ ++  
Sbjct: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487

Query: 578 ILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSN 632
           +L+    ++P +RLG    TG  +IK H FF++I+W LLEK++  PPF+P++       N
Sbjct: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547

Query: 633 FDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
           FD +F +E  +L+  D++ I  +DQS F GF ++NP
Sbjct: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 22/57 (38%), Positives = 33/57 (57%)

Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKC 200
           RRGA +  K++    H F A  F +  +C  C + +WGL +QGY+C  C   +HK+C
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRC 172


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  341 bits (874), Expect = 1e-93
 Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)

Query: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
           H F+   +     C  C   +WGL +QG KC +C + VH KC + V   CG    L  E 
Sbjct: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199

Query: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350
           +  + Q +S  SD A +         E    V  E    N+   GK    SS   + +F 
Sbjct: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255

Query: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410
             +V+G+GS+ KVLL  LK     +A+K +KK++V  D+D++    EK V   A+ +PFL
Sbjct: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315

Query: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470
             L   FQT+  LFFV+E++NGGDLM+H+Q + +     A FY+AEI   L +LH +GII
Sbjct: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375

Query: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530
           YRDLKLDNVLLD +GHIK+ D+GMCKE +      STFCGTP+YIAPEIL+G  Y FSVD
Sbjct: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435

Query: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
           WW+ GVL++EM+ G+SPF           + ED LF+ I       PR ++ ++  +L+ 
Sbjct: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495

Query: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
              ++P +RLG    TG  +I+ HPFF+ ++W ++E++++ PPF+P +       NFD +
Sbjct: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555

Query: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
           F NE  +L+  D +++  +DQS F GF ++NP
Sbjct: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 26/65 (40%), Positives = 36/65 (55%)

Query: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
           RRGA +  K++    H F A  F +   C++C D +WGL +QGYKC  C   +HKKC   
Sbjct: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185

Query: 204 IIGRC 208
           +   C
Sbjct: 186 VTIEC 190


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  318 bits (815), Expect = 1e-86
 Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)

Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
           S   + +F F  VLG+G FGKVLL E +  GE FAIKALKK  ++  D+VE  M EKR+L
Sbjct: 614 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673

Query: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
               +A +PFL +L   FQT +H+ FVME+  GGDLM HI     F   RA FY+A ++ 
Sbjct: 674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 732

Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
           GLQFLH   I+YRDLKLDN+LLD +G++KIADFG+CKE +    R STFCGTP+++APE+
Sbjct: 733 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 792

Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
           L    YT +VDWW  GVLLYEML+G+SPF GDDE+E+F+SI  D   YPR+++ E+  I+
Sbjct: 793 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 852

Query: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
            +L  R P +RLG +     ++K  PFF+T+ W  L  RRL PPF P +    D SNFD+
Sbjct: 853 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912

Query: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
           EF  E   LS   D   + + +Q+AF  F FV
Sbjct: 913 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  318 bits (815), Expect = 1e-86
 Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)

Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
           S   + +F F  VLG+G FGKVLL E +  GE FAIKALKK  ++  D+VE  M EKR+L
Sbjct: 608 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 667

Query: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
               +A +PFL +L   FQT +H+ FVME+  GGDLM HI     F   RA FY+A ++ 
Sbjct: 668 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 726

Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
           GLQFLH   I+YRDLKLDN+LLD +G++KIADFG+CKE +    R STFCGTP+++APE+
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786

Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
           L    YT +VDWW  GVLLYEML+G+SPF GDDE+E+F+SI  D   YPR+++ E+  I+
Sbjct: 787 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 846

Query: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
            +L  R P +RLG +     ++K  PFF+T+ W  L  RRL PPF P +    D SNFD+
Sbjct: 847 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 906

Query: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
           EF  E   LS   D   + + +Q+AF  F FV
Sbjct: 907 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  311 bits (796), Expect = 2e-84
 Identities = 156/329 (47%), Positives = 217/329 (65%), Gaps = 8/329 (2%)

Query: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTL- 403
           N+ +F    VLG+G FGKVLL E K   E FAIKALKK  ++  D+V+  M EKR+    
Sbjct: 653 NLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 712

Query: 404 -AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
            +  +PFL +L   FQTK+H+ FVME+  GGDLM HI     F   RA FYAA ++ GLQ
Sbjct: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQ 771

Query: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522
           +LH   I+YRDLKLDN+LLD +G +KIADFG+CKE +    R STFCGTP+++APE+L  
Sbjct: 772 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 831

Query: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582
             YT +VDWW  GVL+YEML+G+SPF GDDE+E+F+SI  D   YPR+++ E+  I+ +L
Sbjct: 832 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 891

Query: 583 FEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638
             R P +RLG +     ++K HPFF+ I+W+ L  ++++PPF P ++   D SNFD EF 
Sbjct: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951

Query: 639 NEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
           +E   L+   +  ++   +Q  F  F ++
Sbjct: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  310 bits (793), Expect = 4e-84
 Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)

Query: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
           S    + +F   +V+G+GS+ KVLL  LK   + +A+K +KK++V  D+D++    EK V
Sbjct: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120

Query: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
              A+ NPFL  L   FQT   LF V+E++NGGDLM+H+Q + +     A FYAAEI   
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180

Query: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
           L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE +      STFCGTP+YIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240

Query: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
           +G +Y FSVDWW+ GVL++EM+ G+SPF         + ED LF+ I       PR+++ 
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300

Query: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
           ++  +L+    ++P +RLG    TG  +IK H FF++I+W LLEK++  PPF+P++    
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360

Query: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
              NFD +F +E  +L+  D++ I  +DQS F GF ++NP
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  310 bits (793), Expect = 4e-84
 Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)

Query: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
           S    + +F   +V+G+GS+ KVLL  LK   + +A+K +KK++V  D+D++    EK V
Sbjct: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120

Query: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
              A+ NPFL  L   FQT   LF V+E++NGGDLM+H+Q + +     A FYAAEI   
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180

Query: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
           L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE +      STFCGTP+YIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240

Query: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
           +G +Y FSVDWW+ GVL++EM+ G+SPF         + ED LF+ I       PR+++ 
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300

Query: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
           ++  +L+    ++P +RLG    TG  +IK H FF++I+W LLEK++  PPF+P++    
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360

Query: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
              NFD +F +E  +L+  D++ I  +DQS F GF ++NP
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  293 bits (751), Expect = 3e-79
 Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 11/337 (3%)

Query: 324 GEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKD 383
           GE+  D S T+ K      +  +N+F + K+LGKG+FGKV+L   K  G+Y+A+K LKK+
Sbjct: 129 GEEEMDASTTHHK------RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKE 182

Query: 384 VVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKG 443
           V++  D+V  T+ E RVL     +PFLT L  +FQTKD L FVME++NGG+L +H+  + 
Sbjct: 183 VIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241

Query: 444 RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGES 503
            F   R  FY AEI+  L +LHS  I+YRDLKL+N++LD+DGHIKI DFG+CKE I   +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301

Query: 504 RASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD 563
              TFCGTP+Y+APE+L+   Y  +VDWW  GV++YEM+ G+ PF+  D ++LFE I ++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 361

Query: 564 TPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPP 619
              +PR ++ ++K +L  L  ++P KRLG        I  H FF  +NW  +  ++L PP
Sbjct: 362 DIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421

Query: 620 FRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMD 656
           F+P+V S  D   FD+EF  +   ++  +K   D MD
Sbjct: 422 FKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMD 458


>gi|40254851 protein kinase PKNbeta [Homo sapiens]
          Length = 889

 Score =  291 bits (745), Expect = 1e-78
 Identities = 157/325 (48%), Positives = 208/325 (64%), Gaps = 10/325 (3%)

Query: 354 VLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA--ENPFLT 411
           VLG+G FGKVLL + KG G+Y+AIKALKK  VL  D++E    EKR+L       +PFL 
Sbjct: 564 VLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLL 623

Query: 412 HLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIY 471
            L+  FQT  H  FV EF+ GGDLM  I +   F   +A FY A ++ GLQFLH K IIY
Sbjct: 624 SLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FPEPQARFYVACVVLGLQFLHEKKIIY 682

Query: 472 RDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDW 531
           RDLKLDN+LLD  G +KIADFG+CKE I    R STFCGTP+++APE+L    YT +VDW
Sbjct: 683 RDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDW 742

Query: 532 WSFGVLLYEMLIGQSPFHGDDEDELFESI-RVDTPHYPRWITKESKDILEKLFEREPTKR 590
           W  GVLLYEML+G+ PF GD E+E+F+ I  +D P YP +++ +  + ++KL ++ P KR
Sbjct: 743 WGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQKLLQKCPEKR 801

Query: 591 LGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLS- 645
           LG        IK+ PFF+T NW  L  R ++PPF P +  P D   F+ EF      L+ 
Sbjct: 802 LGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTP 861

Query: 646 YSDKNLIDSMDQSAFAGFSFVNPKF 670
            +  +L+ +  Q+AF  F FV+ +F
Sbjct: 862 PAPHSLLTARQQAAFRDFDFVSERF 886


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  290 bits (743), Expect = 2e-78
 Identities = 146/330 (44%), Positives = 213/330 (64%), Gaps = 11/330 (3%)

Query: 324 GEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKD 383
           GE+  D S T+ K      +  +N+F + K+LGKG+FGKV+L   K  G+Y+A+K LKK+
Sbjct: 129 GEEEMDASTTHHK------RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKE 182

Query: 384 VVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKG 443
           V++  D+V  T+ E RVL     +PFLT L  +FQTKD L FVME++NGG+L +H+  + 
Sbjct: 183 VIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241

Query: 444 RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGES 503
            F   R  FY AEI+  L +LHS  I+YRDLKL+N++LD+DGHIKI DFG+CKE I   +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301

Query: 504 RASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD 563
              TFCGTP+Y+APE+L+   Y  +VDWW  GV++YEM+ G+ PF+  D ++LFE I ++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 361

Query: 564 TPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPP 619
              +PR ++ ++K +L  L  ++P KRLG        I  H FF  +NW  +  ++L PP
Sbjct: 362 DIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421

Query: 620 FRPKVKSPRDYSNFDQEFLNEKARLSYSDK 649
           F+P+V S  D   FD+EF  +   ++  +K
Sbjct: 422 FKPQVTSETDTRYFDEEFTAQTITITPPEK 451


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  287 bits (735), Expect = 2e-77
 Identities = 142/332 (42%), Positives = 214/332 (64%), Gaps = 9/332 (2%)

Query: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
           +K  +N+F + K+LGKG+FGKV+L   K  G Y+A+K L+K+V++  D+V  T+ E RVL
Sbjct: 145 AKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL 204

Query: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
                +PFLT L   FQT D L FVME+ NGG+L +H+  +  F   RA FY AEI+  L
Sbjct: 205 Q-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263

Query: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
           ++LHS+ ++YRD+KL+N++LD+DGHIKI DFG+CKE I   +   TFCGTP+Y+APE+L+
Sbjct: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323

Query: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
              Y  +VDWW  GV++YEM+ G+ PF+  D + LFE I ++   +PR ++ E+K +L  
Sbjct: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 383

Query: 582 LFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEF 637
           L +++P +RLG        +  H FF +INW  + +++L PPF+P+V S  D   FD EF
Sbjct: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443

Query: 638 LNEKARLS----YSDKNLIDSMDQSAFAGFSF 665
             +   ++    Y    L++   ++ F  FS+
Sbjct: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  284 bits (727), Expect = 2e-76
 Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)

Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
           G+ +  E++         DNSG       + +   +  +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168

Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
            K  G Y+A+K LKK+V++  D+V  T+ E RVL   + +PFLT L  +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227

Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
           E+ NGG+L +H+  +  F   RA FY AEI+  L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287

Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
           IKI DFG+CKE I   +   TFCGTP+Y+APE+L+   Y  +VDWW  GV++YEM+ G+ 
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347

Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
           PF+  D ++LFE I ++   +PR +  E+K +L  L +++P +RLG        I  H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407

Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
           F  I W  + +++L PPF+P+V S  D   FD+EF  +   ++  D++     +DS  + 
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467

Query: 659 AFAGFSF 665
            F  FS+
Sbjct: 468 HFPQFSY 474


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  284 bits (727), Expect = 2e-76
 Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)

Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
           G+ +  E++         DNSG       + +   +  +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168

Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
            K  G Y+A+K LKK+V++  D+V  T+ E RVL   + +PFLT L  +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227

Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
           E+ NGG+L +H+  +  F   RA FY AEI+  L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287

Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
           IKI DFG+CKE I   +   TFCGTP+Y+APE+L+   Y  +VDWW  GV++YEM+ G+ 
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347

Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
           PF+  D ++LFE I ++   +PR +  E+K +L  L +++P +RLG        I  H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407

Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
           F  I W  + +++L PPF+P+V S  D   FD+EF  +   ++  D++     +DS  + 
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467

Query: 659 AFAGFSF 665
            F  FS+
Sbjct: 468 HFPQFSY 474


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  284 bits (727), Expect = 2e-76
 Identities = 151/367 (41%), Positives = 226/367 (61%), Gaps = 13/367 (3%)

Query: 311 GIYQGFEKKTGVAGEDMQDNSGTYG---KIWEGSSKCNINNFIFHKVLGKGSFGKVLLGE 367
           G+ +  E++         DNSG       + +   +  +N F + K+LGKG+FGKV+L +
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168

Query: 368 LKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVM 427
            K  G Y+A+K LKK+V++  D+V  T+ E RVL   + +PFLT L  +FQT D L FVM
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVM 227

Query: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGH 486
           E+ NGG+L +H+  +  F   RA FY AEI+  L +LHS K ++YRDLKL+N++LD+DGH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287

Query: 487 IKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQS 546
           IKI DFG+CKE I   +   TFCGTP+Y+APE+L+   Y  +VDWW  GV++YEM+ G+ 
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347

Query: 547 PFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHPF 602
           PF+  D ++LFE I ++   +PR +  E+K +L  L +++P +RLG        I  H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407

Query: 603 FKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKN----LIDSMDQS 658
           F  I W  + +++L PPF+P+V S  D   FD+EF  +   ++  D++     +DS  + 
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467

Query: 659 AFAGFSF 665
            F  FS+
Sbjct: 468 HFPQFSY 474


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  271 bits (693), Expect = 1e-72
 Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)

Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
           ++F F KV+GKGSFGKVLL   K    ++A+K L+K  +L   + +  M E+ VL    +
Sbjct: 96  SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155

Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
           +PFL  L  +FQT D L+FV++++NGG+L YH+Q +  F   RA FYAAEI   L +LHS
Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215

Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
             I+YRDLK +N+LLD  GHI + DFG+CKENI   S  STFCGTP+Y+APE+L    Y 
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 275

Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
            +VDWW  G +LYEML G  PF+  +  E++++I          IT  ++ +LE L +++
Sbjct: 276 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 335

Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
            TKRLG   +   IK H FF  INW  L  +++ PPF P V  P D  +FD EF  E   
Sbjct: 336 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 395

Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
            S     D  L+ +  +    AF GFS+  P
Sbjct: 396 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  271 bits (693), Expect = 1e-72
 Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)

Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
           ++F F KV+GKGSFGKVLL   K    ++A+K L+K  +L   + +  M E+ VL    +
Sbjct: 110 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 169

Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
           +PFL  L  +FQT D L+FV++++NGG+L YH+Q +  F   RA FYAAEI   L +LHS
Sbjct: 170 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 229

Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
             I+YRDLK +N+LLD  GHI + DFG+CKENI   S  STFCGTP+Y+APE+L    Y 
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 289

Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
            +VDWW  G +LYEML G  PF+  +  E++++I          IT  ++ +LE L +++
Sbjct: 290 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 349

Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
            TKRLG   +   IK H FF  INW  L  +++ PPF P V  P D  +FD EF  E   
Sbjct: 350 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 409

Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
            S     D  L+ +  +    AF GFS+  P
Sbjct: 410 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  271 bits (693), Expect = 1e-72
 Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)

Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
           ++F F KV+GKGSFGKVLL   K    ++A+K L+K  +L   + +  M E+ VL    +
Sbjct: 124 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 183

Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
           +PFL  L  +FQT D L+FV++++NGG+L YH+Q +  F   RA FYAAEI   L +LHS
Sbjct: 184 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 243

Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
             I+YRDLK +N+LLD  GHI + DFG+CKENI   S  STFCGTP+Y+APE+L    Y 
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 303

Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
            +VDWW  G +LYEML G  PF+  +  E++++I          IT  ++ +LE L +++
Sbjct: 304 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 363

Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
            TKRLG   +   IK H FF  INW  L  +++ PPF P V  P D  +FD EF  E   
Sbjct: 364 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 423

Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
            S     D  L+ +  +    AF GFS+  P
Sbjct: 424 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  271 bits (693), Expect = 1e-72
 Identities = 145/331 (43%), Positives = 199/331 (60%), Gaps = 9/331 (2%)

Query: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
           ++F F KV+GKGSFGKVLL   K    ++A+K L+K  +L   + +  M E+ VL    +
Sbjct: 191 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 250

Query: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS 466
           +PFL  L  +FQT D L+FV++++NGG+L YH+Q +  F   RA FYAAEI   L +LHS
Sbjct: 251 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 310

Query: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYT 526
             I+YRDLK +N+LLD  GHI + DFG+CKENI   S  STFCGTP+Y+APE+L    Y 
Sbjct: 311 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 370

Query: 527 FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERE 586
            +VDWW  G +LYEML G  PF+  +  E++++I          IT  ++ +LE L +++
Sbjct: 371 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 430

Query: 587 PTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKAR 643
            TKRLG   +   IK H FF  INW  L  +++ PPF P V  P D  +FD EF  E   
Sbjct: 431 RTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVP 490

Query: 644 LSYS---DKNLIDSMDQ---SAFAGFSFVNP 668
            S     D  L+ +  +    AF GFS+  P
Sbjct: 491 NSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  269 bits (687), Expect = 7e-72
 Identities = 142/334 (42%), Positives = 200/334 (59%), Gaps = 7/334 (2%)

Query: 348 NFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAEN 407
           +F F KV+GKG++GKVLL + K  G ++A+K L+K  +L   +    M E+ VL     +
Sbjct: 34  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93

Query: 408 PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSK 467
           PFL  L  +FQT + L+FV++++NGG+L +H+Q + RF   RA FYAAE+   + +LHS 
Sbjct: 94  PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153

Query: 468 GIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF 527
            IIYRDLK +N+LLD  GH+ + DFG+CKE +  E   STFCGTP+Y+APE+L+   Y  
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213

Query: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREP 587
           +VDWW  G +LYEML G  PF+  D  +++E+I       P   T  + D+L+ L  ++ 
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273

Query: 588 TKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
            +RLG   +   IK H FF  INW  L  +RL PPF P V  P D  +FD EF  E    
Sbjct: 274 RQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSK 333

Query: 645 SYS---DKNLIDSMDQSAFAGFSFVNPKFEHLLE 675
           S     D     S   SAF GFS+  P+ + +L+
Sbjct: 334 SIGCTPDTVASSSGASSAFLGFSYA-PEDDDILD 366


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  269 bits (687), Expect = 7e-72
 Identities = 142/334 (42%), Positives = 200/334 (59%), Gaps = 7/334 (2%)

Query: 348 NFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAEN 407
           +F F KV+GKG++GKVLL + K  G ++A+K L+K  +L   +    M E+ VL     +
Sbjct: 94  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153

Query: 408 PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSK 467
           PFL  L  +FQT + L+FV++++NGG+L +H+Q + RF   RA FYAAE+   + +LHS 
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213

Query: 468 GIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF 527
            IIYRDLK +N+LLD  GH+ + DFG+CKE +  E   STFCGTP+Y+APE+L+   Y  
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273

Query: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREP 587
           +VDWW  G +LYEML G  PF+  D  +++E+I       P   T  + D+L+ L  ++ 
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 333

Query: 588 TKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644
            +RLG   +   IK H FF  INW  L  +RL PPF P V  P D  +FD EF  E    
Sbjct: 334 RQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSK 393

Query: 645 SYS---DKNLIDSMDQSAFAGFSFVNPKFEHLLE 675
           S     D     S   SAF GFS+  P+ + +L+
Sbjct: 394 SIGCTPDTVASSSGASSAFLGFSYA-PEDDDILD 426


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  266 bits (680), Expect = 5e-71
 Identities = 139/338 (41%), Positives = 207/338 (61%), Gaps = 9/338 (2%)

Query: 340 GSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKR 399
           G+      +F F KV+GKGSFGKVLL + K  G+++A+K L+K +VL   + +  M E+ 
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERN 212

Query: 400 VLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
           VL    ++PFL  L  +FQT + L+FV++F+NGG+L +H+Q +  F  +RA FYAAEI  
Sbjct: 213 VLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIAS 272

Query: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
            L +LHS  I+YRDLK +N+LLD  GH+ + DFG+CKE I      +TFCGTP+Y+APE+
Sbjct: 273 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEV 332

Query: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
           ++   Y  +VDWW  G +LYEML G  PF+  D  E++++I          ++  +  IL
Sbjct: 333 IRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL 392

Query: 580 EKLFEREPTKRLGVTGN---IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
           E+L E++   RLG   +   I+ HPFF++++W  L ++++ PPF P V  P D  NFD  
Sbjct: 393 EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTA 452

Query: 637 FLNEKARLSY---SDKNLIDSM---DQSAFAGFSFVNP 668
           F  E    S    SD +++++       AF GFS+  P
Sbjct: 453 FTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,539,848
Number of Sequences: 37866
Number of extensions: 1153712
Number of successful extensions: 5561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 768
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3006
Number of HSP's gapped (non-prelim): 1223
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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