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Search of human proteins with 30425400
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30425400 G protein-coupled receptor 119 [Homo sapiens]
(335 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30425400 G protein-coupled receptor 119 [Homo sapiens] 663 0.0
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 101 1e-21
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 101 1e-21
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 101 1e-21
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 101 1e-21
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 101 1e-21
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 101 1e-21
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 101 1e-21
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 100 3e-21
gi|4503383 dopamine receptor D1 [Homo sapiens] 98 9e-21
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 96 3e-20
gi|115305569 adenosine A1 receptor [Homo sapiens] 95 8e-20
gi|4501947 adenosine A1 receptor [Homo sapiens] 95 8e-20
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 91 1e-18
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 91 2e-18
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 91 2e-18
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 87 2e-17
gi|5921992 adenosine A2a receptor [Homo sapiens] 87 3e-17
gi|4503391 dopamine receptor D5 [Homo sapiens] 86 5e-17
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 82 5e-16
gi|110618256 trace amine associated receptor 9 [Homo sapiens] 82 9e-16
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 81 1e-15
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 80 3e-15
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 79 7e-15
gi|5174535 melanocortin 5 receptor [Homo sapiens] 77 2e-14
gi|119508433 melanocortin 4 receptor [Homo sapiens] 77 3e-14
gi|4501951 adenosine A2b receptor [Homo sapiens] 76 5e-14
gi|4557865 somatostatin receptor 5 [Homo sapiens] 75 1e-13
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 75 1e-13
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 75 1e-13
>gi|30425400 G protein-coupled receptor 119 [Homo sapiens]
Length = 335
Score = 663 bits (1711), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 1 MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG 60
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
Sbjct: 1 MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG 60
Query: 61 LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF 120
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
Sbjct: 61 LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF 120
Query: 121 VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL 180
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
Sbjct: 121 VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL 180
Query: 181 FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP 240
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
Sbjct: 181 FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP 240
Query: 241 FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV 300
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
Sbjct: 241 FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV 300
Query: 301 LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG 335
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
Sbjct: 301 LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG 335
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 101 bits (251), Expect = 1e-21
Identities = 80/297 (26%), Positives = 134/297 (45%), Gaps = 32/297 (10%)
Query: 8 GVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLS 67
G++++++ I+ N LV A+ + V+ F +LA AD ++G+A+ +
Sbjct: 37 GIVMSLIVLAIVFGNVLVITAIAKF-ERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 95
Query: 68 SPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIA 127
C + AS+ T+ +I DRY AI PF+Y +++ A I
Sbjct: 96 MKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 155
Query: 128 GLWLVSYLIGFLPLGIPMFQQT--------AYKGQCSFFAVFHPHFVLTLSCVGFFPAML 179
+W+VS L FLP+ + ++ T A + C FF + + + S V F+ ++
Sbjct: 156 MVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFT--NQAYAIASSIVSFYVPLV 213
Query: 180 LFVFFYCDMLKIAS------------MHSQQIRKMEHAGAMAGGYR--SPRTPSDFKALR 225
+ VF Y + + A H Q + ++E G G R S + KAL+
Sbjct: 214 IMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALK 273
Query: 226 TVSVLIGSFALSWTPFLITGIVQVACQEC---HLYLVLERYLWLLGVGNSLLNPLIY 279
T+ +++G+F L W PF I IV V +Y++L W +G NS NPLIY
Sbjct: 274 TLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLN---W-IGYVNSGFNPLIY 326
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 101 bits (251), Expect = 1e-21
Identities = 99/354 (27%), Positives = 147/354 (41%), Gaps = 51/354 (14%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GI------PMFQQTAYKGQCSFFAVFHPHFVLTLSC 171
+ G W++ I FLP+ GI F Q + C F + + +T S
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMV--NKPYAITCSV 198
Query: 172 VGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGYRSPRTPSDFKAL 224
V F+ LL V Y + A H+ QI+ ++ AGA A + + R ++ KA
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAA 258
Query: 225 RTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQK 284
+T+ +++G F L W PF +T IV V +LW LG NS LNP +YA+ K
Sbjct: 259 KTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINSGLNPFLYAFLNK 317
Query: 285 EVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHIVTISSS 331
R +FL+ L C ER R S C TI+ S
Sbjct: 318 SFR--------------RAFLIILC---CDDERYRRPSILGQTVPCSTTTINGS 354
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 99.8 bits (247), Expect = 3e-21
Identities = 85/304 (27%), Positives = 133/304 (43%), Gaps = 29/304 (9%)
Query: 11 LAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPS 70
L V+ +L A N+L+ +A++ S F ++L +D ++G+ +
Sbjct: 33 LCVVIALTAAANSLL-IALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR 91
Query: 71 RPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLW 130
+ LC L AF +AS+L + LI+ DRYL I P RY M+ A A + G W
Sbjct: 92 WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Query: 131 LVSYLIGFLPLGIPMFQ----QTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYC 186
++ L FLPL + + + GQC A FVL S + FF F YC
Sbjct: 152 SLAALASFLPLLLGWHELGHARPPVPGQCRLLASL--PFVLVASGLTFFLPSGAICFTYC 209
Query: 187 DMLKIASMHSQQIRKME--HAGAMAGGYRSPRTP------------------SDFKALRT 226
+L A + Q+ + A + + PRTP KA T
Sbjct: 210 RILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLT 269
Query: 227 VSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEV 286
+ +L+G F ++W PF + IVQ C +C + + W LG NS +NP+IY + ++
Sbjct: 270 LGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTW-LGYCNSTMNPIIYPLFMRDF 327
Query: 287 RLQL 290
+ L
Sbjct: 328 KRAL 331
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 98.2 bits (243), Expect = 9e-21
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 41/320 (12%)
Query: 1 MESSFSFGVILAVLASLIIAT----NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGV 56
+E FS ++ A SL+I + NTLV AV+ H V+ F ++LAV+D L+ V
Sbjct: 16 VERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAV 75
Query: 57 AISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKI 116
+ + P + C++ +AF + AS+L + +I+ DRY AI PFRY +
Sbjct: 76 LVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERK 134
Query: 117 MSGFVAGACIAGLWLVSYLIGFLPLGIPMFQ---QTAYKGQCSFFA--------VFHPHF 165
M+ A I+ W +S LI F+P+ + + + G + A +
Sbjct: 135 MTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTY 194
Query: 166 VLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRS----------P 215
++ S + F+ + + + Y + +IA ++I +E A A ++
Sbjct: 195 AISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECS 254
Query: 216 RTPSDF--------KALRTVSVLIGSFALSWTPFLITGIVQVACQE------CHLYLVLE 261
+ S F K L+T+SV++G F W PF I + C C +
Sbjct: 255 QPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFD 314
Query: 262 RYLWLLGVGNSLLNPLIYAY 281
++W G NS LNP+IYA+
Sbjct: 315 VFVW-FGWANSSLNPIIYAF 333
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 96.3 bits (238), Expect = 3e-20
Identities = 99/366 (27%), Positives = 151/366 (41%), Gaps = 61/366 (16%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V+L L+++I+ N LV VAV + F ++LA AD L+ V + +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIK-QPFRYLKIMSGFVAGA 124
L + C +R + AS+ + I+ DRY AI QP Y M+
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 125 CIAGLWLVSYLIGFLPL-------GIPMFQQTAYKG----------------QCSFFAVF 161
+ G W++ I FLP+ GI +++ +G S + VF
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVF 200
Query: 162 --HPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAM-------AGGY 212
+ + +T S V F+ LL V Y + A H+ QI+ ++ AGA A +
Sbjct: 201 MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQH 260
Query: 213 RSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNS 272
+ R ++ KA +T+ +++G F L W PF +T IV V +LW LG NS
Sbjct: 261 STHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLW-LGYINS 319
Query: 273 LLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESS-------CHI 325
LNP +YA+ K R +FL+ L C ER R S C
Sbjct: 320 GLNPFLYAFLNKSFR--------------RAFLIILC---CDDERYRRPSILGQTVPCST 362
Query: 326 VTISSS 331
TI+ S
Sbjct: 363 TTINGS 368
>gi|115305569 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 95.1 bits (235), Expect = 8e-20
Identities = 77/292 (26%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 10 ILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSP 69
I ++A + + N LV AV + D + CF ++LAVAD +G + L L +
Sbjct: 15 IEVLIALVSVPGNVLVIWAVKVNQALRDA-TFCFIVSLAVADVAVGALVIPLAI--LINI 71
Query: 70 SRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGL 129
T C + V +S+L ++ I DRYL +K P RY +++ A IAG
Sbjct: 72 GPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGC 131
Query: 130 WLVSYLIGFLPL----GIPMFQQT-AYKG-------QCSFFAVFHPHFVLTLS-CVGFFP 176
W++S+++G P+ + ++ A G +C F V +++ + V P
Sbjct: 132 WILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLP 191
Query: 177 AMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFAL 236
+LL V Y L++ + +Q+ K A + G + K +++++++ FAL
Sbjct: 192 PLLLMVLIY---LEVFYLIRKQLNKKVSA---SSGDPQKYYGKELKIAKSLALILFLFAL 245
Query: 237 SWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRL 288
SW P I + + C CH +L L GNS +NP++YA+ ++ R+
Sbjct: 246 SWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRV 297
>gi|4501947 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 95.1 bits (235), Expect = 8e-20
Identities = 77/292 (26%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 10 ILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSP 69
I ++A + + N LV AV + D + CF ++LAVAD +G + L L +
Sbjct: 15 IEVLIALVSVPGNVLVIWAVKVNQALRDA-TFCFIVSLAVADVAVGALVIPLAI--LINI 71
Query: 70 SRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGL 129
T C + V +S+L ++ I DRYL +K P RY +++ A IAG
Sbjct: 72 GPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGC 131
Query: 130 WLVSYLIGFLPL----GIPMFQQT-AYKG-------QCSFFAVFHPHFVLTLS-CVGFFP 176
W++S+++G P+ + ++ A G +C F V +++ + V P
Sbjct: 132 WILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLP 191
Query: 177 AMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFAL 236
+LL V Y L++ + +Q+ K A + G + K +++++++ FAL
Sbjct: 192 PLLLMVLIY---LEVFYLIRKQLNKKVSA---SSGDPQKYYGKELKIAKSLALILFLFAL 245
Query: 237 SWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRL 288
SW P I + + C CH +L L GNS +NP++YA+ ++ R+
Sbjct: 246 SWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRV 297
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 91.3 bits (225), Expect = 1e-18
Identities = 77/320 (24%), Positives = 134/320 (41%), Gaps = 52/320 (16%)
Query: 8 GVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLS 67
G+++A++ LI+A N LV VA+ +L F ++LA AD ++G+ + +
Sbjct: 62 GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNL-FIMSLASADLVMGLLVVPFGATIVV 120
Query: 68 SPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIA 127
C L + AS+ T+ +I DRYLAI PFRY +++ A +
Sbjct: 121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC 180
Query: 128 GLWLVSYLIGFLPLGIPMFQQTAYKGQ--------CSFFAVFHPHFVLTLSCVGFFPAML 179
+W +S L+ FLP+ + ++ + + + C F V + + + S V F+ +
Sbjct: 181 TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDF--VTNRAYAIASSVVSFYVPLC 238
Query: 180 LFVFFYCDMLKIASMHSQQIRKMEH----------------------------------A 205
+ F Y + + A ++I E
Sbjct: 239 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT 298
Query: 206 GAMAGGYRSPRTPS------DFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLV 259
+A G R PS + KAL+T+ +++G F L W PF + +V+ +E +
Sbjct: 299 APLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRL 358
Query: 260 LERYLWLLGVGNSLLNPLIY 279
+ W LG NS NP+IY
Sbjct: 359 FVFFNW-LGYANSAFNPIIY 377
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 90.5 bits (223), Expect = 2e-18
Identities = 70/283 (24%), Positives = 130/283 (45%), Gaps = 13/283 (4%)
Query: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSS 68
V+LAVL + +A N +V +AV L + ++ CF ++LA+ D L+G+ + S
Sbjct: 23 VVLAVLILITVAGNVVVCLAVGLN-RRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLS 81
Query: 69 PSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAG 128
K C++ + AS+L + +I+ DRY A+ P RY +++ +
Sbjct: 82 CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVL 141
Query: 129 LWLVSYLIGFLP--LGIPMFQQTAYKGQCSFFAVFHPHFVLTL--SCVGFFPAMLLFVFF 184
+W++S + FL LG +T+ + + V L V F+ +L+
Sbjct: 142 IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCIT 201
Query: 185 YCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLIT 244
Y + K+A Q +++ H + T + KA T++ ++G+F + W P+
Sbjct: 202 YYRIFKVA---RDQAKRINHISSWKAA-----TIREHKATVTLAAVMGAFIICWFPYFTA 253
Query: 245 GIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVR 287
+ + + + VLE + LG NS LNP++YA ++ R
Sbjct: 254 FVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFR 296
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 90.5 bits (223), Expect = 2e-18
Identities = 70/283 (24%), Positives = 130/283 (45%), Gaps = 13/283 (4%)
Query: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSS 68
V+LAVL + +A N +V +AV L + ++ CF ++LA+ D L+G+ + S
Sbjct: 23 VVLAVLILITVAGNVVVCLAVGLN-RRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLS 81
Query: 69 PSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAG 128
K C++ + AS+L + +I+ DRY A+ P RY +++ +
Sbjct: 82 CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVL 141
Query: 129 LWLVSYLIGFLP--LGIPMFQQTAYKGQCSFFAVFHPHFVLTL--SCVGFFPAMLLFVFF 184
+W++S + FL LG +T+ + + V L V F+ +L+
Sbjct: 142 IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCIT 201
Query: 185 YCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLIT 244
Y + K+A Q +++ H + T + KA T++ ++G+F + W P+
Sbjct: 202 YYRIFKVA---RDQAKRINHISSWKAA-----TIREHKATVTLAAVMGAFIICWFPYFTA 253
Query: 245 GIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVR 287
+ + + + VLE + LG NS LNP++YA ++ R
Sbjct: 254 FVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFR 296
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 87.0 bits (214), Expect = 2e-17
Identities = 80/289 (27%), Positives = 128/289 (44%), Gaps = 20/289 (6%)
Query: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSS 68
V+L V ++I N LV VA++ +LA AD L G + Q
Sbjct: 77 VLLCVSGTVIAGENALV-VALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLV 135
Query: 69 PSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAG 128
PS +T+ L + F+ +S AASV +++ IT DRYL++ Y + +A
Sbjct: 136 PS----ETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA 191
Query: 129 LWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDM 188
W VS +G LP + + A + CS V LS FF + + Y +
Sbjct: 192 TWTVSLGLGLLP--VLGWNCLAERAACSVVRPLARSHVALLS-AAFFMVFGIMLHLYVRI 248
Query: 189 LKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQ 248
++ H+ QI +H A P + K + T++V++G+F SW PF I +V
Sbjct: 249 CQVVWRHAHQIALQQHCLA------PPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVV- 301
Query: 249 VACQECHLYLVLERYLWLL-GVGNSLLNPLIYAYWQKEVRLQLYHMALG 296
H + Y LL NS++NP+IYA+ +E++ L+ + G
Sbjct: 302 ----GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCG 346
>gi|5921992 adenosine A2a receptor [Homo sapiens]
Length = 412
Score = 86.7 bits (213), Expect = 3e-17
Identities = 90/308 (29%), Positives = 142/308 (46%), Gaps = 36/308 (11%)
Query: 1 MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG 60
M SS V LA+ A L I N LV AV L + + V+ F ++LA AD +GV
Sbjct: 4 MGSSVYITVELAI-AVLAILGNVLVCWAVWLNSNLQN-VTNYFVVSLAAADIAVGV---- 57
Query: 61 LLTDQLSSPSRPTQKTL-------CSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRY 113
L+ P T T C FV +S+ +++ I DRY+AI+ P RY
Sbjct: 58 -----LAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRY 112
Query: 114 LKIMSGFVAGACIAGLWLVSYLIGFLPL------GIPM----FQQTAYKGQ--CSFFAVF 161
+++G A IA W++S+ IG P+ G P Q +GQ C F V
Sbjct: 113 NGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV 172
Query: 162 HPHFVLTLSCVGFFPAMLLFVFFYCDM-LKIASMHSQQIRKMEHAGAMAGGYRSPRTPSD 220
++++ + FF +L+ + + L+I +Q+++ME + + G +
Sbjct: 173 PMNYMVYFN---FFACVLVPLLLMLGVYLRIFLAARRQLKQME-SQPLPGERARSTLQKE 228
Query: 221 FKALRTVSVLIGSFALSWTPFLITGIVQVACQEC-HLYLVLERYLWLLGVGNSLLNPLIY 279
A +++++++G FAL W P I C +C H L L +L NS++NP IY
Sbjct: 229 VHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIY 288
Query: 280 AYWQKEVR 287
AY +E R
Sbjct: 289 AYRIREFR 296
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 85.9 bits (211), Expect = 5e-17
Identities = 82/322 (25%), Positives = 137/322 (42%), Gaps = 51/322 (15%)
Query: 9 VILAVLASLIIAT---NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQ 65
V +L LII T N LV A++ H ++ F ++LAV+D + + +
Sbjct: 42 VTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVA 101
Query: 66 LSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGAC 125
+ P C + +AF + AS+L + +I+ DRY AI +PFRY + M+ +A
Sbjct: 102 EVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVM 160
Query: 126 IAGLWLVSYLIGFLPLGIPMFQ-QTAYKGQCSF---FAVFHPH----------------- 164
+ W +S LI F+P+ + + Q A G A + P
Sbjct: 161 VGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSS 220
Query: 165 ----FVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRS-----P 215
+ ++ S + F+ + + + Y + +IA + ++I +E A A RS P
Sbjct: 221 LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAP 280
Query: 216 RTP------SDFKALRTVSVLIGSFALSWTPFLITGIVQVACQ----------ECHLYLV 259
T + K L+T+SV++G F W PF I + C C
Sbjct: 281 DTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETT 340
Query: 260 LERYLWLLGVGNSLLNPLIYAY 281
+ ++W G NS LNP+IYA+
Sbjct: 341 FDVFVW-FGWANSSLNPVIYAF 361
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 82.4 bits (202), Expect = 5e-16
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 51/320 (15%)
Query: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGL-LTDQLS 67
++ AV+ L IA N LV +AV L K + F ++LA+AD L+G + + + L
Sbjct: 79 LLTAVVIILTIAGNILVIMAVSLE-KKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 137
Query: 68 SPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIA 127
P LC++ + + AS++ + I+ DRY+AI+ P + + S A I
Sbjct: 138 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 197
Query: 128 GLWLVSYLIGFLPLGIPMF-----QQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFV 182
+W +S +G + + IP+F + +G C + +FVL S V FF + + V
Sbjct: 198 AVWTIS--VG-ISMPIPVFGLQDDSKVFKEGSC---LLADDNFVLIGSFVSFFIPLTIMV 251
Query: 183 FFYCDMLKIASMHSQQIRKMEHAGAMA---------------------------GGYRSP 215
Y L I S+ + + G A G Y
Sbjct: 252 ITY--FLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGR 309
Query: 216 RT----PSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQE-CH---LYLVLERYLWLL 267
RT ++ KA + + ++ F + W PF IT I+ V C+E C+ + +L ++W +
Sbjct: 310 RTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVW-I 368
Query: 268 GVGNSLLNPLIYAYWQKEVR 287
G +S +NPL+Y + K R
Sbjct: 369 GYLSSAVNPLVYTLFNKTYR 388
>gi|110618256 trace amine associated receptor 9 [Homo sapiens]
Length = 348
Score = 81.6 bits (200), Expect = 9e-16
Identities = 72/294 (24%), Positives = 124/294 (42%), Gaps = 38/294 (12%)
Query: 7 FGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQL 66
FG +LA +L++ ++A+ +H + +LA AD L+GV + T +
Sbjct: 41 FGAVLAAFGNLLV----MIAILHFKQLHTPTNFLIA---SLACADFLVGVTVMPFSTVRS 93
Query: 67 SSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACI 126
+ C F TS AS+ + I+ DRY+A+ P Y + V+G CI
Sbjct: 94 VESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICI 153
Query: 127 AGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPA-------ML 179
W S F +F A + V+ L+CVG A +L
Sbjct: 154 VLSWFFSVTYSF-----SIFYTGANEEGIE-------ELVVALTCVGGCQAPLNQNWVLL 201
Query: 180 LFVFFYCDMLKIASMHSQ-------QIRKMEHAGAMA----GGYRSPRTPSDFKALRTVS 228
F+ F+ + + ++S+ Q RK+E + A Y+ + KA +T+
Sbjct: 202 CFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQSSSESYKERVAKRERKAAKTLG 261
Query: 229 VLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYW 282
+ + +F +SW P+L+ ++ V E +W + NS +NPLIYA++
Sbjct: 262 IAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV-YYNSAMNPLIYAFF 314
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 81.3 bits (199), Expect = 1e-15
Identities = 72/307 (23%), Positives = 122/307 (39%), Gaps = 31/307 (10%)
Query: 7 FGVILAVLASLIIATN---TLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGL-L 62
FGV++ L ++A L+ +A +L + V ++AV+D L+ + L L
Sbjct: 39 FGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSL 98
Query: 63 TDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVA 122
+LS + LC L +A AS+ V I DRY +I + Y V+
Sbjct: 99 VHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVS 158
Query: 123 GACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFV 182
IA W +S +I PL + + +T +G P + + + F+ + + +
Sbjct: 159 NVMIALTWALSAVISLAPL-LFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVL 217
Query: 183 FFYCDMLK-----IASMHSQQIRKMEHAGAMAGGYRSP--------------------RT 217
F Y + K + S + + + A + + P R
Sbjct: 218 FVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWRE 277
Query: 218 PSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPL 277
+ +A V +LIG F L W PF +T ++ C C + + + LG NS NPL
Sbjct: 278 QKEQRAALMVGILIGVFVLCWIPFFLTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPL 336
Query: 278 IYAYWQK 284
IY + K
Sbjct: 337 IYTAFNK 343
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 79.7 bits (195), Expect = 3e-15
Identities = 75/291 (25%), Positives = 134/291 (46%), Gaps = 24/291 (8%)
Query: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTL--NLAVADTLIGVAISGLLTDQL 66
++L +LI N A+ VL++ H + F L +LA+AD L G+ GL+T+ +
Sbjct: 49 IVLCTSGTLISCEN---AIVVLIIFHNPSLRAPMFLLIGSLALADLLAGI---GLITNFV 102
Query: 67 SSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACI 126
+ ++ T + + + +S +ASV +++ IT DRYL++ Y + +
Sbjct: 103 FAYLLQSEATKL-VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVML 161
Query: 127 AGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYC 186
LW S +G LP + + + CS + LS V F L + Y
Sbjct: 162 VMLWGTSICLGLLP--VMGWNCLRDESTCSVVRPLTKNNAAILS-VSFLFMFALMLQLYI 218
Query: 187 DMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGI 246
+ KI H+ QI ++H Y + R K + T+++++G+FA W PF + +
Sbjct: 219 QICKIVMRHAHQIA-LQHHFLATSHYVTTR-----KGVSTLAIILGTFAACWMPFTLYSL 272
Query: 247 VQVACQECHLYLVLERYLWLL-GVGNSLLNPLIYAYWQKEVRLQLYHMALG 296
+ + Y + Y LL NS++NP+IYA+ +E++ L + G
Sbjct: 273 I-----ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCG 318
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 78.6 bits (192), Expect = 7e-15
Identities = 77/315 (24%), Positives = 128/315 (40%), Gaps = 52/315 (16%)
Query: 8 GVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLS 67
G +LA+ + N LV VA+ ++ F +LA AD ++G+ +
Sbjct: 41 GALLALAVLATVGGNLLVIVAIAWTPRLQTMTNV-FVTSLAAADLVMGLLVVPPAATLAL 99
Query: 68 SPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIA 127
+ P T C L + AS+ T+ + DRYLA+ P RY +++ A +
Sbjct: 100 TGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVV 159
Query: 128 GLWLVSYLIGFLPL-------GIPMFQQTAYKG-QCSFFAVFHPHFVLTLSCVGFFPAML 179
+W+VS + F P+ G Q + +C FA P +VL S V F+ +L
Sbjct: 160 LVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMP-YVLLSSSVSFYLPLL 218
Query: 180 LFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPS-------------------- 219
+ +F Y + +A ++Q+R + SP PS
Sbjct: 219 VMLFVYARVFVVA---TRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
Query: 220 -----------DFKALRTVSVLIGSFALSWTPFLITGIVQV----ACQECHLYLVLERYL 264
+ +AL T+ +++G+F L W PF + +++ + +L L
Sbjct: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALN--- 332
Query: 265 WLLGVGNSLLNPLIY 279
W LG NS NPLIY
Sbjct: 333 W-LGYANSAFNPLIY 346
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 77.0 bits (188), Expect = 2e-14
Identities = 63/256 (24%), Positives = 115/256 (44%), Gaps = 37/256 (14%)
Query: 43 FTLNLAVADTLIGVAISG------LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTV 96
F +LAVAD L+ ++ + LL ++ + + + ++ + + S AS+ ++
Sbjct: 74 FVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSL 133
Query: 97 MLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCS 156
+ I DRY+ I RY IM+ +GA IAG+W A+ C
Sbjct: 134 LAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIW-------------------AFCTGCG 174
Query: 157 FFAVFHPHFVLTLSCV--GFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRS 214
+ + + C+ FF + L V Y M +A H ++I A G S
Sbjct: 175 IVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRI-------AALPGASS 227
Query: 215 PRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQE---CHLYLVLERYLWLLGVGN 271
R + + TV++L+G F + W PF + + ++C + C ++ +L + N
Sbjct: 228 ARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCN 287
Query: 272 SLLNPLIYAYWQKEVR 287
S+++PLIYA+ +E+R
Sbjct: 288 SVMDPLIYAFRSQEMR 303
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 76.6 bits (187), Expect = 3e-14
Identities = 73/295 (24%), Positives = 125/295 (42%), Gaps = 35/295 (11%)
Query: 2 ESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTL-NLAVADTLIGVAISG 60
E F + L + + N LV VA+ +KN + F + +LAVAD L+ V+
Sbjct: 42 EQLFVSPEVFVTLGVISLLENILVIVAIAK--NKNLHSPMYFFICSLAVADMLVSVSNGS 99
Query: 61 --LLTDQLSSPSRPTQKTLCSLRMAF---VTSSAAASVLTVMLITFDRYLAIKQPFRYLK 115
++ L+S Q ++ + SS AS+ +++ I DRY I +Y
Sbjct: 100 ETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHN 159
Query: 116 IMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFF 175
IM+ G I+ +W + G L F V+ FF
Sbjct: 160 IMTVKRVGIIISCIWAACTVSGIL-----------------FIIYSDSSAVIICLITMFF 202
Query: 176 PAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFA 235
+ L Y M +A +H ++I + GA+ G ++ K T+++LIG F
Sbjct: 203 TMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQG-------ANMKGAITLTILIGVFV 255
Query: 236 LSWTPFLITGIVQVACQE---CHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVR 287
+ W PF + I ++C + C ++ +L + NS+++PLIYA +E+R
Sbjct: 256 VCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELR 310
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 75.9 bits (185), Expect = 5e-14
Identities = 79/316 (25%), Positives = 137/316 (43%), Gaps = 43/316 (13%)
Query: 13 VLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGV-AISGLLTDQLSSPSR 71
V+A+L +A N LV AV + F ++LA AD +G+ AI +T L
Sbjct: 16 VIAALSVAGNVLVCAAVGTANTLQTPTNY-FLVSLAAADVAVGLFAIPFAITISLGFC-- 72
Query: 72 PTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWL 131
T C FV +S+ +++ + DRYLAI P RY +++G A IA LW+
Sbjct: 73 -TDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWV 131
Query: 132 VSYLIGFLP-LG-----------IPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFF---- 175
+++ IG P LG + T + C +F V+ +S + +F
Sbjct: 132 LAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFEN--VVPMSYMVYFNFFG 189
Query: 176 ---PAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIG 232
P +L+ + Y + +A Q+ M+H+ + A +++++++G
Sbjct: 190 CVLPPLLIMLVIYIKIFLVACRQLQRTELMDHS--------RTTLQREIHAAKSLAMIVG 241
Query: 233 SFALSWTPFLITGIVQV--ACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQL 290
FAL W P V + Q + LL NS++NP++YAY ++ R
Sbjct: 242 IFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTF 301
Query: 291 YHMALGVKKVLTSFLL 306
+ K+++ +LL
Sbjct: 302 H-------KIISRYLL 310
>gi|4557865 somatostatin receptor 5 [Homo sapiens]
Length = 364
Score = 74.7 bits (182), Expect = 1e-13
Identities = 86/302 (28%), Positives = 131/302 (43%), Gaps = 30/302 (9%)
Query: 9 VILAVLASLIIAT----NTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTD 64
V++ VL L+ A NTLV + V+L K V+ + LNLAVAD L + + L T
Sbjct: 41 VLVPVLYLLVCAAGLGGNTLV-IYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQ 99
Query: 65 QLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGA 124
+S P LC L M + SV + +++ DRYLA+ P + VA
Sbjct: 100 NAAS-FWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKL 158
Query: 125 CIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSF-----FAVFHPHFVLTLSCVGFFPAML 179
A W++S + LPL + F G C+ ++ F++ + +GFF +L
Sbjct: 159 ASAAAWVLSLCMS-LPLLV--FADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLL 215
Query: 180 LFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWT 239
V C +L + K+ AG G R S+ K R V V++ FA W
Sbjct: 216 --VICLCYLLIVV--------KVRAAGVRVG---CVRRRSERKVTRMVLVVVLVFAGCWL 262
Query: 240 PFLITGIVQ--VACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGV 297
PF IV VA + L ++ +L NS NP++Y + R Q + L +
Sbjct: 263 PFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFR-QSFQKVLCL 321
Query: 298 KK 299
+K
Sbjct: 322 RK 323
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 18 IIATNTLVAVAVLLLIHKNDGVSLCFTL-NLAVADTLIGVAISGLLTDQLSSPSRPTQKT 76
I+ N LV VA+ +++ + + + NLA AD G+A L+ + + R T T
Sbjct: 63 IMLANLLVMVAIY--VNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST 120
Query: 77 LCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLI 136
LR + +S ASV ++ I +R++ + + + ++ + V I +W ++ ++
Sbjct: 121 WL-LRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVV-VVIVVIWTMAIVM 178
Query: 137 GFLP-LGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMH 195
G +P +G CS A + L + ++ V Y + +
Sbjct: 179 GAIPSVGWNCICDIE---NCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIF--GYVR 233
Query: 196 SQQIRKMEHAGAMAGGYRSPRTPSD--FKALRTVSVLIGSFALSWTPFLITGIVQVACQE 253
+ +R H+ PR D L+TV +++G+F + WTP L+ ++ V C +
Sbjct: 234 QRTMRMSRHSSG-------PRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Query: 254 CHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEV 286
C + L E++ LL NS +NP+IY+Y KE+
Sbjct: 287 CDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 18 IIATNTLVAVAVLLLIHKNDGVSLCFTL-NLAVADTLIGVAISGLLTDQLSSPSRPTQKT 76
I+ N LV VA+ +++ + + + NLA AD G+A L+ + + R T T
Sbjct: 63 IMLANLLVMVAIY--VNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST 120
Query: 77 LCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLI 136
LR + +S ASV ++ I +R++ + + + ++ + V I +W ++ ++
Sbjct: 121 WL-LRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVV-VVIVVIWTMAIVM 178
Query: 137 GFLP-LGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMH 195
G +P +G CS A + L + ++ V Y + +
Sbjct: 179 GAIPSVGWNCICDIE---NCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIF--GYVR 233
Query: 196 SQQIRKMEHAGAMAGGYRSPRTPSD--FKALRTVSVLIGSFALSWTPFLITGIVQVACQE 253
+ +R H+ PR D L+TV +++G+F + WTP L+ ++ V C +
Sbjct: 234 QRTMRMSRHSSG-------PRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Query: 254 CHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEV 286
C + L E++ LL NS +NP+IY+Y KE+
Sbjct: 287 CDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEM 318
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.329 0.140 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,256,234
Number of Sequences: 37866
Number of extensions: 443222
Number of successful extensions: 2521
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 447
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 1409
Number of HSP's gapped (non-prelim): 941
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.