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Search of human proteins with 30387611
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo
sapiens]
(502 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens] 1035 0.0
gi|4502745 cyclin-dependent kinase 8 [Homo sapiens] 781 0.0
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 206 5e-53
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 203 3e-52
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 201 1e-51
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 201 1e-51
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 201 1e-51
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 200 2e-51
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 198 8e-51
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 197 2e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 192 5e-49
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 186 6e-47
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 186 6e-47
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 186 6e-47
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 181 1e-45
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 179 4e-45
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 179 4e-45
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 179 4e-45
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 176 4e-44
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 174 2e-43
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 172 5e-43
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens] 169 5e-42
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 169 5e-42
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 169 5e-42
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 168 9e-42
>gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens]
Length = 502
Score = 1035 bits (2676), Expect = 0.0
Identities = 502/502 (100%), Positives = 502/502 (100%)
Query: 1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS 60
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
Sbjct: 1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS 60
Query: 61 MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
Sbjct: 61 MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
Query: 121 MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
Sbjct: 121 MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
Query: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
Sbjct: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300
Query: 301 KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN 360
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
Sbjct: 301 KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN 360
Query: 361 EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG 420
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
Sbjct: 361 EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG 420
Query: 421 AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST 480
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
Sbjct: 421 AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST 480
Query: 481 LGYSSSSQQSSQYHPSHQAHRY 502
LGYSSSSQQSSQYHPSHQAHRY
Sbjct: 481 LGYSSSSQQSSQYHPSHQAHRY 502
>gi|4502745 cyclin-dependent kinase 8 [Homo sapiens]
Length = 464
Score = 781 bits (2018), Expect = 0.0
Identities = 389/502 (77%), Positives = 417/502 (83%), Gaps = 38/502 (7%)
Query: 1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS 60
MDYDFK KL++ERERVEDLFEYEGCKVGRGTYGHVYKA+RKDGKD+K+YALKQIEGTGIS
Sbjct: 1 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 60
Query: 61 MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
MSACREIALLRELKHPNVI+LQKVFLSH+DRKVWLLFDYAEHDLWHIIKFHRASKANKKP
Sbjct: 61 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
Query: 121 MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
+QLPR MVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
Sbjct: 121 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
Query: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300
IKTSNP+HHDQLDRIF+VMGFPADKDWEDI+KMPE+ TL KDFRR TY N SLIKYMEKH
Sbjct: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300
Query: 301 KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN 360
KVKPDSK F LLQKLLTMDP KRITSEQA+QDPYF EDPLPT DVFAGCQIPYPKREFL
Sbjct: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 360
Query: 361 EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG 420
E++P++KGDK QQQ QQ + TNGT
Sbjct: 361 EEEPDDKGDKKNQQQ-----------------------QQGNNHTNGT------------ 385
Query: 421 AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST 480
G +QDSS Q PP KK R+ P SGG +M SDYQ S+ Y + +SQ QS+
Sbjct: 386 -GHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSS 444
Query: 481 LGYSSSSQQSSQYHPSHQAHRY 502
+GYS++SQQ QY SHQ HRY
Sbjct: 445 MGYSATSQQPPQY--SHQTHRY 464
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 206 bits (523), Expect = 5e-53
Identities = 126/321 (39%), Positives = 190/321 (59%), Gaps = 41/321 (12%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
K+G GTYG VYKA+ ++ + ALK+I E G+ +A REI+LL+ELKHPN++ L
Sbjct: 9 KIGEGTYGVVYKAKNRE--TGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRL 66
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
V H++RK++L+F++ DL + S +LP ++KS L+Q+L G+ +
Sbjct: 67 LDVV--HNERKLYLVFEFLSQDLKKYMDSTPGS-------ELPLHLIKSYLFQLLQGVSF 117
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H++ V+HRDLKP N+L+ E G +K+AD G AR F PL+ VVT WYRA
Sbjct: 118 CHSHRVIHRDLKPQNLLIN----ELGAIKLADFGLARAFGVPLRTYTH---EVVTLWYRA 170
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PE+LLG++ YT A+DIW+IGCIFAE++T + +F E DQL RIF ++G
Sbjct: 171 PEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSE---------IDQLFRIFRMLGT 221
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++ W + ++P+Y + F + T I ++P+ + LL +LL DP+
Sbjct: 222 PSEDTWPGVTQLPDY---KGSFPKWTRKGLEEI----VPNLEPEGRD--LLMQLLQYDPS 272
Query: 322 KRITSEQALQDPYFQE-DPLP 341
+RIT++ AL PYF +P P
Sbjct: 273 QRITAKTALAHPYFSSPEPSP 293
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 419 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 476
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 477 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 528
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 529 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 581
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 582 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 632
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 633 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 685
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 686 RRISAEDGLKHEYFRETPLP 705
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 428 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 537
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 538 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 590
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 591 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 641
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 642 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 694
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 695 RRISAEDGLKHEYFRETPLP 714
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 396 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 453
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 454 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 505
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 506 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 558
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 559 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 609
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 610 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 662
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 663 RRISAEDGLKHEYFRETPLP 682
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 385 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 442
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 443 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 494
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 495 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 547
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 548 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 598
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 599 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 651
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 652 RRISAEDGLKHEYFRETPLP 671
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 174 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 231
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 232 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 283
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 284 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 336
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 337 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 387
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 388 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 440
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 441 RRISAEDGLKHEYFRETPLP 460
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 203 bits (517), Expect = 3e-52
Identities = 115/320 (35%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 430 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 487
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 488 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 539
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 540 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 592
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 593 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 643
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 644 PSEKIWPGYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 696
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 697 RRISAEDGLKHEYFRETPLP 716
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 201 bits (512), Expect = 1e-51
Identities = 115/320 (35%), Positives = 187/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 418 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 475
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 476 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 527
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 528 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTQWYRA 580
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F E DQ++++F +G
Sbjct: 581 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSE---------IDQINKVFKELGT 631
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 632 PSEKIWPGYSELPV-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 684
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 685 RRISAEDGLKHEYFRETPLP 704
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 201 bits (512), Expect = 1e-51
Identities = 115/320 (35%), Positives = 187/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++ GTYG VY+A KD K ++ ALK++ E G +++ REI + + +HPN++ +
Sbjct: 428 RIEEGTYGVVYRA--KDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
+++ + + K++++ +Y EHDL +++ K+P LP VK+L+ Q+L G+ +
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LPGE-VKTLMIQLLRGVKH 537
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 538 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTQWYRA 590
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F E DQ++++F +G
Sbjct: 591 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSE---------IDQINKVFKELGT 641
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 321
P++K W ++P ++ T++ ++ + F L+ K LT P
Sbjct: 642 PSEKIWPGYSELPV-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 694
Query: 322 KRITSEQALQDPYFQEDPLP 341
+RI++E L+ YF+E PLP
Sbjct: 695 RRISAEDGLKHEYFRETPLP 714
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 201 bits (512), Expect = 1e-51
Identities = 129/326 (39%), Positives = 184/326 (56%), Gaps = 46/326 (14%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
K+G GTYG VYKAR K + ALK+I E G+ +A REI+LL+EL HPN++ L
Sbjct: 9 KIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
V H++ K++L+F++ DL KF AS P+ L +KS L+Q+L G+ +
Sbjct: 67 LDVI--HTENKLYLVFEFLHQDLK---KFMDASALTGIPLPL----IKSYLFQLLQGLAF 117
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H++ VLHRDLKP N+L+ EG +K+AD G AR F P++ VVT WYRA
Sbjct: 118 CHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRA 170
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PE+LLG ++Y+ A+DIW++GCIFAE++T +F E DQL RIF +G
Sbjct: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE---------IDQLFRIFRTLGT 221
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKP--DSKVFLLLQKLLTMD 319
P + W + MP+Y + R ++ KV P D LL ++L D
Sbjct: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFS-----------KVVPPLDEDGRSLLSQMLHYD 270
Query: 320 PTKRITSEQALQDPYFQE--DPLPTL 343
P KRI+++ AL P+FQ+ P+P L
Sbjct: 271 PNKRISAKAALAHPFFQDVTKPVPHL 296
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 200 bits (509), Expect = 2e-51
Identities = 125/327 (38%), Positives = 183/327 (55%), Gaps = 43/327 (13%)
Query: 16 VEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLR 71
+ED + E K+G GTYG VYK R K + A+K+I E G+ +A REI+LL+
Sbjct: 1 MEDYTKIE--KIGEGTYGVVYKGRHKT--TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56
Query: 72 ELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQ-LPRSMVKS 130
EL+HPN+++LQ V + D +++L+F++ DL + + P Q + S+VKS
Sbjct: 57 ELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLD-------SIPPGQYMDSSLVKS 107
Query: 131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 190
LYQIL GI + H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++
Sbjct: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH- 162
Query: 191 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHD 250
VVT WYR+PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E D
Sbjct: 163 --EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------ID 211
Query: 251 QLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFL 310
QL RIF +G P ++ W ++ + +Y ++ + A+ H D
Sbjct: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS---------HVKNLDENGLD 262
Query: 311 LLQKLLTMDPTKRITSEQALQDPYFQE 337
LL K+L DP KRI+ + AL PYF +
Sbjct: 263 LLSKMLIYDPAKRISGKMALNHPYFND 289
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 198 bits (504), Expect = 8e-51
Identities = 123/327 (37%), Positives = 182/327 (55%), Gaps = 43/327 (13%)
Query: 16 VEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLR 71
+ED + E K+G GTYG VYK R K + A+K+I E G+ +A REI+LL+
Sbjct: 1 MEDYTKIE--KIGEGTYGVVYKGRHKT--TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56
Query: 72 ELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQ-LPRSMVKS 130
EL+HPN+++LQ V + D +++L+F++ DL + + P Q + S+VKS
Sbjct: 57 ELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLD-------SIPPGQYMDSSLVKS 107
Query: 131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 190
LYQIL GI + H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++
Sbjct: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH- 162
Query: 191 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHD 250
+T WYR+PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E D
Sbjct: 163 --EAITLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------ID 211
Query: 251 QLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFL 310
QL RIF +G P ++ W ++ + +Y ++ + A+ H D
Sbjct: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS---------HVKNLDENGLD 262
Query: 311 LLQKLLTMDPTKRITSEQALQDPYFQE 337
LL K+L DP KRI+ + AL PYF +
Sbjct: 263 LLSKMLIYDPAKRISGKMALNHPYFND 289
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 197 bits (501), Expect = 2e-50
Identities = 123/321 (38%), Positives = 177/321 (55%), Gaps = 40/321 (12%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
++G GTYG VY+AR D + ++ ALK++ E GI +S+ REI LL L+HPN++ L
Sbjct: 44 RIGEGTYGIVYRAR--DTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 101
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
++V + + ++L+ Y E DL AS P + VK ++ Q+L G+ Y
Sbjct: 102 KEVVVGNHLESIFLVMGYCEQDL--------ASLLENMPTPFSEAQVKCIVLQVLRGLQY 153
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH N+++HRDLK +N+L+ ++G VK AD G AR + P+KP+ P VVT WYRA
Sbjct: 154 LHRNFIIHRDLKVSNLLMT----DKGCVKTADFGLARAYGVPVKPMT---PKVVTLWYRA 206
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 261
PELLLG T +ID+WA+GCI AELL P+ + ++ H Q+D I ++G
Sbjct: 207 PELLLGTTTQTTSIDMWAVGCILAELLAHRPL-------LPGTSEIH--QIDLIVQLLGT 257
Query: 262 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDP 320
P++ W K+P Q R+ Y N KHK S+ L LL L DP
Sbjct: 258 PSENIWPGFSKLPLVG--QYSLRKQPYNNL-------KHKFPWLSEAGLRLLHFLFMYDP 308
Query: 321 TKRITSEQALQDPYFQEDPLP 341
KR T+ L+ YF+E PLP
Sbjct: 309 KKRATAGDCLESSYFKEKPLP 329
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 192 bits (489), Expect = 5e-49
Identities = 119/317 (37%), Positives = 179/317 (56%), Gaps = 42/317 (13%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL 81
K+G GTYG V+KA+ ++ + ALK++ + G+ SA REI LL+ELKH N++ L
Sbjct: 9 KIGEGTYGTVFKAKNRE--THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66
Query: 82 QKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHY 141
V HSD+K+ L+F++ + DL K+ + + P +VKS L+Q+L G+ +
Sbjct: 67 HDVL--HSDKKLTLVFEFCDQDLK---KYFDSCNGDLDP-----EIVKSFLFQLLKGLGF 116
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H+ VLHRDLKP N+L+ G +K+AD G AR F P++ + VVT WYR
Sbjct: 117 CHSRNVLHRDLKPQNLLIN----RNGELKLADFGLARAFGIPVRCYS---AEVVTLWYRP 169
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPFHHDQLDRIFSVMG 260
P++L GA+ Y+ +ID+W+ GCIFAEL + P+F D DQL RIF ++G
Sbjct: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKRIFRLLG 220
Query: 261 FPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDP 320
P ++ W + K+P+Y A +SL+ + K LLQ LL +P
Sbjct: 221 TPTEEQWPSMTKLPDYKPYP-----MYPATTSLVNVVPKLNATGRD----LLQNLLKCNP 271
Query: 321 TKRITSEQALQDPYFQE 337
+RI++E+ALQ PYF +
Sbjct: 272 VQRISAEEALQHPYFSD 288
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 186 bits (471), Expect = 6e-47
Identities = 154/503 (30%), Positives = 233/503 (46%), Gaps = 76/503 (15%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKA+ KD + ALK++ E G ++A REI +
Sbjct: 721 KRCVDKFDIIGI-IGEGTYGQVYKAKDKDTGEL--VALKKVRLDNEKEGFPITAIREIKI 777
Query: 70 LRELKHPNVIALQKVFLSHSDR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPM 121
LR+L H +V+ ++++ D +L+F+Y +HDL +++ +
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 829
Query: 122 QLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ G ++K+AD G ARL+N
Sbjct: 830 HFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG----QIKLADFGLARLYN 885
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF E
Sbjct: 886 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE- 941
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTL--QKDFRRTTYANSSLIKYME 298
QL+ I + G P W D+ K+P + T+ +K +RR S I
Sbjct: 942 --------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFI---- 989
Query: 299 KHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPL-----PTLDVFAGCQIPY 353
S LL +LT+DP+KR T+EQ LQ + ++ L P L + C +
Sbjct: 990 ------PSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELW 1043
Query: 354 PKREFLNEDD---PEEKGDKNQQQQQNQHQQPTAPPQQAA-APPQAPPPQQNSTQTNGTA 409
K+ EE +++ T P + ++ APPQ P + S
Sbjct: 1044 SKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVES------- 1096
Query: 410 GGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQS 469
GAG +G Q LNQ L S + P M + + S Q
Sbjct: 1097 -GAGDAIGLADITQQ------LNQSELAVLLNLLQSQTDLSIPQM-AQLLNIHSNPEMQQ 1148
Query: 470 SVQGSSQSQSTLGYSSSSQQSSQ 492
++ +QS S L ++S QQ S+
Sbjct: 1149 QLEALNQSISALTEATSQQQDSE 1171
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 186 bits (471), Expect = 6e-47
Identities = 154/503 (30%), Positives = 233/503 (46%), Gaps = 76/503 (15%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKA+ KD + ALK++ E G ++A REI +
Sbjct: 721 KRCVDKFDIIGI-IGEGTYGQVYKAKDKDTGEL--VALKKVRLDNEKEGFPITAIREIKI 777
Query: 70 LRELKHPNVIALQKVFLSHSDR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPM 121
LR+L H +V+ ++++ D +L+F+Y +HDL +++ +
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 829
Query: 122 QLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ G ++K+AD G ARL+N
Sbjct: 830 HFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG----QIKLADFGLARLYN 885
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF E
Sbjct: 886 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE- 941
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTL--QKDFRRTTYANSSLIKYME 298
QL+ I + G P W D+ K+P + T+ +K +RR S I
Sbjct: 942 --------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFI---- 989
Query: 299 KHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPL-----PTLDVFAGCQIPY 353
S LL +LT+DP+KR T+EQ LQ + ++ L P L + C +
Sbjct: 990 ------PSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELW 1043
Query: 354 PKREFLNEDD---PEEKGDKNQQQQQNQHQQPTAPPQQAA-APPQAPPPQQNSTQTNGTA 409
K+ EE +++ T P + ++ APPQ P + S
Sbjct: 1044 SKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVES------- 1096
Query: 410 GGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQS 469
GAG +G Q LNQ L S + P M + + S Q
Sbjct: 1097 -GAGDAIGLADITQQ------LNQSELAVLLNLLQSQTDLSIPQM-AQLLNIHSNPEMQQ 1148
Query: 470 SVQGSSQSQSTLGYSSSSQQSSQ 492
++ +QS S L ++S QQ S+
Sbjct: 1149 QLEALNQSISALTEATSQQQDSE 1171
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 186 bits (471), Expect = 6e-47
Identities = 127/337 (37%), Positives = 174/337 (51%), Gaps = 53/337 (15%)
Query: 27 VGRGTYGHVYKARRKDGKDEKEYALKQIE-------GTGISMSACREIALLRELKHPNVI 79
+G G + VYKAR K+ + A+K+I+ GI+ +A REI LL+EL HPN+I
Sbjct: 18 LGEGQFATVYKARDKN--TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75
Query: 80 ALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGI 139
L F S+ + L+FD+ E DL IIK + L S +K+ + L G+
Sbjct: 76 GLLDAFGHKSN--ISLVFDFMETDLEVIIK--------DNSLVLTPSHIKAYMLMTLQGL 125
Query: 140 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWY 199
YLH +W+LHRDLKP N+L+ E G +K+AD G A+ F SP + VVT WY
Sbjct: 126 EYLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRWY 178
Query: 200 RAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVM 259
RAPELL GAR Y +D+WA+GCI AELL P F D+ DQL RIF +
Sbjct: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVP-FLPGDSDL--------DQLTRIFETL 229
Query: 260 GFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKV--KPDSKVFLLLQKLLT 317
G P ++ W D+ +P+Y T + + H + + L+Q L
Sbjct: 230 GTPTEEQWPDMCSLPDYVTFKS------------FPGIPLHHIFSAAGDDLLDLIQGLFL 277
Query: 318 MDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYP 354
+P RIT+ QAL+ YF P PT GCQ+P P
Sbjct: 278 FNPCARITATQALKMKYFSNRPGPT----PGCQLPRP 310
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 181 bits (459), Expect = 1e-45
Identities = 114/301 (37%), Positives = 161/301 (53%), Gaps = 36/301 (11%)
Query: 55 EGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P + VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLI 294
+ ++ H Q+D I ++G P++ W K+P Q R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLPLVG--QYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKVFL-LLQKLLTMDPTKRITSEQALQDPYFQEDP--LPTLDVFAGCQI 351
KHK S+ L LL L DP KR T+ L+ YF+E P LP V GC+
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLRLPISGVCEGCRE 270
Query: 352 P 352
P
Sbjct: 271 P 271
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 179 bits (455), Expect = 4e-45
Identities = 110/288 (38%), Positives = 156/288 (54%), Gaps = 34/288 (11%)
Query: 55 EGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P + VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLI 294
+ ++ H Q+D I ++G P++ W K+P Q R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLPLVG--QYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKVFL-LLQKLLTMDPTKRITSEQALQDPYFQEDPLP 341
KHK S+ L LL L DP KR T+ L+ YF+E PLP
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLP 258
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 179 bits (455), Expect = 4e-45
Identities = 123/363 (33%), Positives = 189/363 (52%), Gaps = 57/363 (15%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKAR KD + ALK++ E G ++A REI +
Sbjct: 699 KRCVDKFDIIGI-IGEGTYGQVYKARDKDTGEM--VALKKVRLDNEKEGFPITAIREIKI 755
Query: 70 LRELKHPNVIALQKVFLSHSDR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPM 121
LR+L H ++I ++++ D +L+F+Y +HDL +++ +
Sbjct: 756 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 807
Query: 122 QLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+ +KS + Q+++G+ Y H LHRD+K +NIL+ RG++K+AD G ARL++
Sbjct: 808 HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN----RGQIKLADFGLARLYS 863
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF QE
Sbjct: 864 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE- 919
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTL--QKDFRRTTYANSSLIKYME 298
QL+ I + G P W D+ K+P + T+ +K +RR K E
Sbjct: 920 --------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------KLRE 962
Query: 299 KHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQE-----DPLPTLDVFAGCQIPY 353
+ P + L +L +DP+KR T+EQALQ + ++ P P L ++ C +
Sbjct: 963 EFVFIP-AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELW 1021
Query: 354 PKR 356
K+
Sbjct: 1022 SKK 1024
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 179 bits (455), Expect = 4e-45
Identities = 123/363 (33%), Positives = 189/363 (52%), Gaps = 57/363 (15%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKAR KD + ALK++ E G ++A REI +
Sbjct: 699 KRCVDKFDIIGI-IGEGTYGQVYKARDKDTGEM--VALKKVRLDNEKEGFPITAIREIKI 755
Query: 70 LRELKHPNVIALQKVFLSHSDR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPM 121
LR+L H ++I ++++ D +L+F+Y +HDL +++ +
Sbjct: 756 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 807
Query: 122 QLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+ +KS + Q+++G+ Y H LHRD+K +NIL+ RG++K+AD G ARL++
Sbjct: 808 HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN----RGQIKLADFGLARLYS 863
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF QE
Sbjct: 864 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE- 919
Query: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTL--QKDFRRTTYANSSLIKYME 298
QL+ I + G P W D+ K+P + T+ +K +RR K E
Sbjct: 920 --------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------KLRE 962
Query: 299 KHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQE-----DPLPTLDVFAGCQIPY 353
+ P + L +L +DP+KR T+EQALQ + ++ P P L ++ C +
Sbjct: 963 EFVFIP-AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELW 1021
Query: 354 PKR 356
K+
Sbjct: 1022 SKK 1024
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 176 bits (446), Expect = 4e-44
Identities = 124/359 (34%), Positives = 185/359 (51%), Gaps = 46/359 (12%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQIE---GTGISMSACREIALLRELKHPNVIALQ 82
K+G GTY VYK R K E ALK+I G +A RE++LL++LKH N++ L
Sbjct: 197 KLGEGTYATVYKGRSK--LTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 254
Query: 83 KVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYL 142
+ H+D+ + L+F+Y + DL K + N M VK LYQIL G+ Y
Sbjct: 255 DIV--HTDKSLTLVFEYLDKDL----KQYMDDCGNIMSMH----NVKLFLYQILRGLAYC 304
Query: 143 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 202
H VLHRDLKP N+L+ E+G +K+AD G AR + P K ++ VVT WYR P
Sbjct: 305 HRRKVLHRDLKPQNLLIN----EKGELKLADFGLARAKSVPTKTYSN---EVVTLWYRPP 357
Query: 203 ELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFP 262
++LLG+ Y+ ID+W +GCIF E+ + P+F D+L IF ++G P
Sbjct: 358 DVLLGSSEYSTQIDMWGVGCIFFEMASGRPLF---------PGSTVEDELHLIFRLLGTP 408
Query: 263 ADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTK 322
+ + W I E+ K++ Y LI H + DS+ L+ K L + K
Sbjct: 409 SQETWPGISSNEEF----KNYNFPKYKPQPLI----NHAPRLDSEGIELITKFLQYESKK 460
Query: 323 RITSEQALQDPYFQE-----DPLP-TLDVFAGCQIPYPKRE-FLNEDDPEEKGDKNQQQ 374
R+++E+A++ YF+ LP ++ +F+ +I K F N PE KN++Q
Sbjct: 461 RVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQ 519
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 174 bits (440), Expect = 2e-43
Identities = 123/328 (37%), Positives = 173/328 (52%), Gaps = 55/328 (16%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQIE-------GTGISMSACREIALLRELK---H 75
++G G YG VYKAR D ALK + G G+ +S RE+ALLR L+ H
Sbjct: 11 EIGVGAYGTVYKAR--DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68
Query: 76 PNVIALQKVFL-SHSDR--KVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLL 132
PNV+ L V S +DR KV L+F++ + DL R P LP +K L+
Sbjct: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDL-------RTYLDKAPPPGLPAETIKDLM 121
Query: 133 YQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP 192
Q L G+ +LHAN ++HRDLKP NILV G VK+AD G AR+++ + L P
Sbjct: 122 RQFLRGLDFLHANCIVHRDLKPENILV----TSGGTVKLADFGLARIYSYQMA----LTP 173
Query: 193 VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQL 252
VVVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F E DQL
Sbjct: 174 VVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE---------ADQL 223
Query: 253 DRIFSVMGFPADKDWEDIRKMPE--YPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFL 310
+IF ++G P + DW +P +P R S++ ME+ +
Sbjct: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPP------RGPRPVQSVVPEMEESGAQ------- 270
Query: 311 LLQKLLTMDPTKRITSEQALQDPYFQED 338
LL ++LT +P KRI++ +ALQ Y +D
Sbjct: 271 LLLEMLTFNPHKRISAFRALQHSYLHKD 298
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 172 bits (437), Expect = 5e-43
Identities = 125/390 (32%), Positives = 192/390 (49%), Gaps = 57/390 (14%)
Query: 17 EDLFEYEG-CKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLR 71
+++ +YE K+G+GT+G V+KAR + K ++ ALK++ E G ++A REI +L+
Sbjct: 14 DEVSKYEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGFPITALREIKILQ 71
Query: 72 ELKHPNVIALQKVFLSHSDR------KVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPR 125
LKH NV+ L ++ + + ++L+FD+ EHDL A + ++
Sbjct: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL--------AGLLSNVLVKFTL 123
Query: 126 SMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLK 185
S +K ++ +L+G++Y+H N +LHRD+K AN+L+ +G +K+AD G AR F+
Sbjct: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKN 179
Query: 186 PLAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTS 244
+ VVT WYR PELLLG R Y ID+W GCI AE+ T PI E
Sbjct: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE----- 234
Query: 245 NPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKP 304
QL I + G + W ++ Y L+ L+K +K KVK
Sbjct: 235 ----QHQLALISQLCGSITPEVWPNVDNYELYEKLE------------LVK-GQKRKVKD 277
Query: 305 DSKVFL-------LLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKRE 357
K ++ L+ KLL +DP +RI S+ AL +F DP+P+ G +
Sbjct: 278 RLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPS--DLKGMLSTHLTSM 335
Query: 358 FLNEDDPEEKGDKNQQQQQNQHQQPTAPPQ 387
F P KG + QQ NQ + P Q
Sbjct: 336 FEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365
>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
Length = 283
Score = 169 bits (428), Expect = 5e-42
Identities = 106/287 (36%), Positives = 152/287 (52%), Gaps = 38/287 (13%)
Query: 55 EGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P + VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLI 294
+ ++ H Q+D I ++G P++ W K+P Q R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLPLVG--QYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLP 341
KHK S+ L L L M T+ L+ YF+E PLP
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFM-----ATAGDCLESSYFKEKPLP 252
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 169 bits (428), Expect = 5e-42
Identities = 119/359 (33%), Positives = 177/359 (49%), Gaps = 59/359 (16%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQIE---GTGISMSACREIALLRELKHPNVIALQ 82
K+G GTY VYK + K + ALK+I G +A RE++LL++LKH N++ L
Sbjct: 176 KLGEGTYATVYKGKSK--LTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 233
Query: 83 KVFLSHSDRKVWLLFDYAEHDL-------WHIIKFHRASKANKKPMQLPRSMVKSLLYQI 135
+ H+++ + L+F+Y + DL +II H VK L+Q+
Sbjct: 234 DII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHN---------------VKLFLFQL 276
Query: 136 LDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195
L G+ Y H VLHRDLKP N+L+ ERG +K+AD G AR + P K ++ VV
Sbjct: 277 LRGLAYCHRQKVLHRDLKPQNLLIN----ERGELKLADFGLARAKSIPTKTYSN---EVV 329
Query: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRI 255
T WYR P++LLG+ Y+ ID+W +GCIF E+ T P+F +QL I
Sbjct: 330 TLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF---------PGSTVEEQLHFI 380
Query: 256 FSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKL 315
F ++G P ++ W I E+ K + Y +L+ H + DS LL KL
Sbjct: 381 FRILGTPTEETWPGILSNEEF----KTYNYPKYRAEALL----SHAPRLDSDGADLLTKL 432
Query: 316 LTMDPTKRITSEQALQDPYF-----QEDPLP-TLDVFAGCQIPYPKREFLNEDDPEEKG 368
L + RI++E A++ P+F + LP T +FA +I K L + G
Sbjct: 433 LQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 491
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 169 bits (428), Expect = 5e-42
Identities = 119/359 (33%), Positives = 177/359 (49%), Gaps = 59/359 (16%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEYALKQIE---GTGISMSACREIALLRELKHPNVIALQ 82
K+G GTY VYK + K + ALK+I G +A RE++LL++LKH N++ L
Sbjct: 170 KLGEGTYATVYKGKSK--LTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 227
Query: 83 KVFLSHSDRKVWLLFDYAEHDL-------WHIIKFHRASKANKKPMQLPRSMVKSLLYQI 135
+ H+++ + L+F+Y + DL +II H VK L+Q+
Sbjct: 228 DII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHN---------------VKLFLFQL 270
Query: 136 LDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195
L G+ Y H VLHRDLKP N+L+ ERG +K+AD G AR + P K ++ VV
Sbjct: 271 LRGLAYCHRQKVLHRDLKPQNLLIN----ERGELKLADFGLARAKSIPTKTYSN---EVV 323
Query: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRI 255
T WYR P++LLG+ Y+ ID+W +GCIF E+ T P+F +QL I
Sbjct: 324 TLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF---------PGSTVEEQLHFI 374
Query: 256 FSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKL 315
F ++G P ++ W I E+ K + Y +L+ H + DS LL KL
Sbjct: 375 FRILGTPTEETWPGILSNEEF----KTYNYPKYRAEALL----SHAPRLDSDGADLLTKL 426
Query: 316 LTMDPTKRITSEQALQDPYF-----QEDPLP-TLDVFAGCQIPYPKREFLNEDDPEEKG 368
L + RI++E A++ P+F + LP T +FA +I K L + G
Sbjct: 427 LQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 485
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 168 bits (426), Expect = 9e-42
Identities = 117/324 (36%), Positives = 182/324 (56%), Gaps = 51/324 (15%)
Query: 26 KVGRGTYGHVYKARRKDGKDEKEY-ALKQIE----GTGISMSACREIALLRELK---HPN 77
++G G YG V+KAR D K+ + ALK++ G+ +S RE+A+LR L+ HPN
Sbjct: 18 EIGEGAYGKVFKAR--DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75
Query: 78 VIALQKVF-LSHSDR--KVWLLFDYAEHDLWHIIKFHRASKANKKPMQ-LPRSMVKSLLY 133
V+ L V +S +DR K+ L+F++ + DL + +K P +P +K +++
Sbjct: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDL--------TTYLDKVPEPGVPTETIKDMMF 127
Query: 134 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 193
Q+L G+ +LH++ V+HRDLKP NILV G++K+AD G AR+++ + L V
Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSS----GQIKLADFGLARIYSFQMA----LTSV 179
Query: 194 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLD 253
VVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F D+ DQL
Sbjct: 180 VVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFR-GSSDV--------DQLG 229
Query: 254 RIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQ 313
+I V+G P ++DW +P R+ ++ S+ + +EK D LL
Sbjct: 230 KILDVIGLPGEEDWPRDVALP---------RQAFHSKSA--QPIEKFVTDIDELGKDLLL 278
Query: 314 KLLTMDPTKRITSEQALQDPYFQE 337
K LT +P KRI++ AL PYFQ+
Sbjct: 279 KCLTFNPAKRISAYSALSHPYFQD 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,911,231
Number of Sequences: 37866
Number of extensions: 1155433
Number of successful extensions: 16042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 761
Number of HSP's successfully gapped in prelim test: 616
Number of HSP's that attempted gapping in prelim test: 9718
Number of HSP's gapped (non-prelim): 4389
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.