Search of human proteins with 30089948

Search of human proteins with 30089948

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30089948 protein phosphatase 1E [Homo sapiens]
         (755 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30089948 protein phosphatase 1E [Homo sapiens]                    1553   0.0  
gi|7661862 protein phosphatase 1F [Homo sapiens]                      368   e-101
gi|13540531 integrin-linked kinase-associated protein phosphatas...   122   2e-27
gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]   115   1e-25
gi|167466276 protein phosphatase 1K (PP2C domain containing) [Ho...   110   4e-24
gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]           104   3e-22
gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]           104   3e-22
gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]            104   3e-22
gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]           103   5e-22
gi|122937199 protein phosphatase 1B-like [Homo sapiens]               102   1e-21
gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]            94   5e-19
gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]            94   6e-19
gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]           94   6e-19
gi|4505999 protein phosphatase 1G [Homo sapiens]                       91   5e-18
gi|29826282 protein phosphatase 1G [Homo sapiens]                      91   5e-18
gi|4505997 protein phosphatase 1D [Homo sapiens]                       81   4e-15
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 58   3e-08
gi|37221175 PH domain and leucine rich repeat protein phosphatas...    56   1e-07
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    55   2e-07
gi|158420731 chromodomain helicase DNA binding protein 3 isoform...    54   4e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              54   5e-07
gi|156523246 proline-rich transmembrane protein 2 [Homo sapiens]       54   5e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    52   2e-06
gi|222144283 hypothetical protein LOC65998 [Homo sapiens]              52   2e-06
gi|110349786 Alstrom syndrome 1 [Homo sapiens]                         52   2e-06
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              52   2e-06
gi|55741677 SET domain containing 1A [Homo sapiens]                    52   3e-06
gi|45935385 SAM and SH3 domain containing 1 [Homo sapiens]             51   3e-06
gi|215820635 protein phosphatase 1, regulatory subunit 13 like [...    51   5e-06
gi|63003907 protein phosphatase 1, regulatory subunit 13 like [H...    51   5e-06

>gi|30089948 protein phosphatase 1E [Homo sapiens]
          Length = 755

 Score = 1553 bits (4021), Expect = 0.0
 Identities = 755/755 (100%), Positives = 755/755 (100%)

Query: 1   MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAE 60
           MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAE
Sbjct: 1   MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAE 60

Query: 61  ASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQ 120
           ASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQ
Sbjct: 61  ASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQ 120

Query: 121 LPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSA 180
           LPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSA
Sbjct: 121 LPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSA 180

Query: 181 HYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNM 240
           HYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNM
Sbjct: 181 HYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNM 240

Query: 241 RRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPH 300
           RRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPH
Sbjct: 241 RRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPH 300

Query: 301 DPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQA 360
           DPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQA
Sbjct: 301 DPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQA 360

Query: 361 VELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSAS 420
           VELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSAS
Sbjct: 361 VELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSAS 420

Query: 421 TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDN 480
           TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDN
Sbjct: 421 TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDN 480

Query: 481 ITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADL 540
           ITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADL
Sbjct: 481 ITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADL 540

Query: 541 GYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKA 600
           GYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKA
Sbjct: 541 GYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKA 600

Query: 601 NLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSP 660
           NLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSP
Sbjct: 601 NLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSP 660

Query: 661 GNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTGSGKRNRIRSSL 720
           GNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTGSGKRNRIRSSL
Sbjct: 661 GNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTGSGKRNRIRSSL 720

Query: 721 PWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE 755
           PWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE
Sbjct: 721 PWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE 755


>gi|7661862 protein phosphatase 1F [Homo sapiens]
          Length = 454

 Score =  368 bits (945), Expect = e-101
 Identities = 200/385 (51%), Positives = 253/385 (65%), Gaps = 12/385 (3%)

Query: 118 PPQLPPLPPLP-RPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQS 176
           P  L P  PLP +     +++EEVEGE  +L +  L     P  LAAALA     ++LQ+
Sbjct: 31  PALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQT 90

Query: 177 DLSA-HYIPKETDGTEGTVE---------IETVKLARSVFSKLHEICCSWVKDFPLRRRP 226
           DLS    +P+E +  E   +         ++   LA+S F++L E+   W K  PL  R 
Sbjct: 91  DLSEFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARA 150

Query: 227 -QLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYAS 285
            Q  +  SIHAI+N RRKMED+HV +P FN LF L D   +AYFAVFDGHGGVDAA YA+
Sbjct: 151 SQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAA 210

Query: 286 IHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVA 345
           +H+H N  RQ   P DP  AL  AFR TD+ F++KA RE L+ GTTGV   I G  LHVA
Sbjct: 211 VHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVA 270

Query: 346 WVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGD 405
           W+GDSQV+LV++GQ V+LM+PH+P+R+DEK RIEALGG V     WRVNG+L+VSRAIGD
Sbjct: 271 WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGD 330

Query: 406 AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVA 465
              KPY+ G+AD+AS  L G+EDYL+LACDGF+D V   E V +V  HL    G    VA
Sbjct: 331 VFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVA 390

Query: 466 HKLVASARDAGSSDNITVIVVFLRD 490
            +LVA+AR+ GS DNITV+VVFLRD
Sbjct: 391 EELVAAARERGSHDNITVMVVFLRD 415


>gi|13540531 integrin-linked kinase-associated protein phosphatase
           2C [Homo sapiens]
          Length = 392

 Score =  122 bits (305), Expect = 2e-27
 Identities = 92/281 (32%), Positives = 142/281 (50%), Gaps = 39/281 (13%)

Query: 238 KNMRRKMEDKHVCIPDFNMLFNLEDQ--EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ 295
           K  R +M+D HV + D               +YFAVFDGHGG+ A+ +A+ +LH NL+R+
Sbjct: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK 174

Query: 296 EMFPHDPA--------EALCRAFRVTDERFVQKAA--RESLRCGTTGVVTFIRGNMLHVA 345
             FP              L   F+ TDE F+++A+  + + + G+T        N+L++A
Sbjct: 175 --FPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIA 232

Query: 346 WVGDSQVMLVR------KGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSV 399
            +GDS+ +L R      K  A+ L K H P + +E+ RI+  GG V      RV G L V
Sbjct: 233 NLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNV---RDGRVLGVLEV 289

Query: 400 SRAIGDAEHKPYICGDA---DSASTVLDGTEDYLILACDGFYDTVNPDEAVKVV-----S 451
           SR+IGD ++K   CG     D     L   + +++LACDG +    P+EAV  +      
Sbjct: 290 SRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347

Query: 452 DHLKENNGDSSMVA------HKLVASARDAGSSDNITVIVV 486
           + ++   G S+  A      ++L   A   GS+DN+TV+VV
Sbjct: 348 EKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388


>gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]
          Length = 360

 Score =  115 bits (289), Expect = 1e-25
 Identities = 85/276 (30%), Positives = 141/276 (51%), Gaps = 22/276 (7%)

Query: 230 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 289
           +  ++++I+  R  MED+      F +L +L ++   + F +FDGHGG  AA Y    L 
Sbjct: 91  HNVAVYSIQGRRDHMEDR------FEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLP 144

Query: 290 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLR--------CGTTGVVTFIRGNM 341
             L +         E    +++   E+ +    RE L          GTT ++  +    
Sbjct: 145 EALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKD 204

Query: 342 LHVAWVGDSQVMLVRK-GQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVS 400
           L VA VGDS+ +L  K G A+ L   HKP +  E++RI+  GG + + G+WRV G L++S
Sbjct: 205 LTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMS 264

Query: 401 RAIGD--AEHKPYICGDADSASTVLDGTE-DYLILACDGFYDTVNPDEAVKVVSDHLKEN 457
           R++GD   ++   +  D D  +  LD  + +++ILA DG +D  + +EAV+ + + L E 
Sbjct: 265 RSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEP 324

Query: 458 NGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNK 493
           +      A  +V  +   G  DNITV+VV  R+ +K
Sbjct: 325 H----FGAKSIVLQSFYRGCPDNITVMVVKFRNSSK 356


>gi|167466276 protein phosphatase 1K (PP2C domain containing) [Homo
           sapiens]
          Length = 372

 Score =  110 bits (276), Expect = 4e-24
 Identities = 82/234 (35%), Positives = 121/234 (51%), Gaps = 18/234 (7%)

Query: 264 EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDP--AEALCRAFRVTDERFVQKA 321
           +E  YFAV+DGHGG  AA +   H H+     ++ P +      L  AF   D+ F   A
Sbjct: 118 DEVLYFAVYDGHGGPAAADFC--HTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHA 175

Query: 322 ARES----LRCGTTGVVTFIR-GNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQ 376
              +    L  GTT  V  +R G  L VA VGDS+ +L RKG+ ++L   H P+R+DEK+
Sbjct: 176 RLSADATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKE 235

Query: 377 RIEALGGCVVW--FGAWRVNGSLSVSRAIGDAEHKPY-ICGDADSASTVLDGTED-YLIL 432
           RI+  GG V W   G   VNG L+++R+IGD + K   +  + ++    L   +D +L+L
Sbjct: 236 RIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVL 295

Query: 433 ACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVV 486
             DG    VN  E    + D + + + D +  AH +   A   G+ DN T +VV
Sbjct: 296 TTDGINFMVNSQE----ICDFVNQCH-DPNEAAHAVTEQAIQYGTEDNSTAVVV 344


>gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]
          Length = 380

 Score =  104 bits (259), Expect = 3e-22
 Identities = 103/364 (28%), Positives = 161/364 (44%), Gaps = 57/364 (15%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +    +   LED    ++FAV+DGH G   A Y S HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAV--VGIPHGLEDW---SFFAVYDGHAGSRVANYCSTHLLEHIT 80

Query: 294 RQEMFP-------------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIR 338
             E F               +    +   F   DE  R          R G+T V   I 
Sbjct: 81  TNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMIS 140

Query: 339 GNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLS 398
              ++    GDS+ +L R GQ     + HKP    EK+RI+  GG V+     RVNGSL+
Sbjct: 141 PKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM---IQRVNGSLA 197

Query: 399 VSRAIGDAEHKPYICGDADSASTVLDGTE------------DYLILACDGFYDTVNPDEA 446
           VSRA+GD ++K   C D    +  L   E            +++ILACDG +D ++ +E 
Sbjct: 198 VSRALGDYDYK---CVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEEL 254

Query: 447 VKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTEN 506
            + V   L E + D   V + +V +    GS DN+++++V     + A  VS+E+   ++
Sbjct: 255 CEYVKSRL-EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVC---FSNAPKVSDEAVKKDS 310

Query: 507 SFQGGQEDGGDD-KENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQI---- 561
                 E   ++  E  GE   P          DL +  R+ S  +  +L PG  +    
Sbjct: 311 ELDKHLESRVEEIMEKSGEEGMP----------DLAHVMRILSAENIPNLPPGGGLAGKR 360

Query: 562 NVLE 565
           NV+E
Sbjct: 361 NVIE 364


>gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]
          Length = 387

 Score =  104 bits (259), Expect = 3e-22
 Identities = 103/364 (28%), Positives = 161/364 (44%), Gaps = 57/364 (15%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +    +   LED    ++FAV+DGH G   A Y S HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAV--VGIPHGLEDW---SFFAVYDGHAGSRVANYCSTHLLEHIT 80

Query: 294 RQEMFP-------------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIR 338
             E F               +    +   F   DE  R          R G+T V   I 
Sbjct: 81  TNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMIS 140

Query: 339 GNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLS 398
              ++    GDS+ +L R GQ     + HKP    EK+RI+  GG V+     RVNGSL+
Sbjct: 141 PKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM---IQRVNGSLA 197

Query: 399 VSRAIGDAEHKPYICGDADSASTVLDGTE------------DYLILACDGFYDTVNPDEA 446
           VSRA+GD ++K   C D    +  L   E            +++ILACDG +D ++ +E 
Sbjct: 198 VSRALGDYDYK---CVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEEL 254

Query: 447 VKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTEN 506
            + V   L E + D   V + +V +    GS DN+++++V     + A  VS+E+   ++
Sbjct: 255 CEYVKSRL-EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVC---FSNAPKVSDEAVKKDS 310

Query: 507 SFQGGQEDGGDD-KENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQI---- 561
                 E   ++  E  GE   P          DL +  R+ S  +  +L PG  +    
Sbjct: 311 ELDKHLESRVEEIMEKSGEEGMP----------DLAHVMRILSAENIPNLPPGGGLAGKR 360

Query: 562 NVLE 565
           NV+E
Sbjct: 361 NVIE 364


>gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]
          Length = 479

 Score =  104 bits (259), Expect = 3e-22
 Identities = 103/364 (28%), Positives = 161/364 (44%), Gaps = 57/364 (15%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +    +   LED    ++FAV+DGH G   A Y S HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAV--VGIPHGLEDW---SFFAVYDGHAGSRVANYCSTHLLEHIT 80

Query: 294 RQEMFP-------------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIR 338
             E F               +    +   F   DE  R          R G+T V   I 
Sbjct: 81  TNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMIS 140

Query: 339 GNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLS 398
              ++    GDS+ +L R GQ     + HKP    EK+RI+  GG V+     RVNGSL+
Sbjct: 141 PKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM---IQRVNGSLA 197

Query: 399 VSRAIGDAEHKPYICGDADSASTVLDGTE------------DYLILACDGFYDTVNPDEA 446
           VSRA+GD ++K   C D    +  L   E            +++ILACDG +D ++ +E 
Sbjct: 198 VSRALGDYDYK---CVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEEL 254

Query: 447 VKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTEN 506
            + V   L E + D   V + +V +    GS DN+++++V     + A  VS+E+   ++
Sbjct: 255 CEYVKSRL-EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVC---FSNAPKVSDEAVKKDS 310

Query: 507 SFQGGQEDGGDD-KENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQI---- 561
                 E   ++  E  GE   P          DL +  R+ S  +  +L PG  +    
Sbjct: 311 ELDKHLESRVEEIMEKSGEEGMP----------DLAHVMRILSAENIPNLPPGGGLAGKR 360

Query: 562 NVLE 565
           NV+E
Sbjct: 361 NVIE 364


>gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]
          Length = 327

 Score =  103 bits (258), Expect = 5e-22
 Identities = 91/315 (28%), Positives = 142/315 (45%), Gaps = 42/315 (13%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +    +   LED    ++FAV+DGH G   A Y S HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAV--VGIPHGLEDW---SFFAVYDGHAGSRVANYCSTHLLEHIT 80

Query: 294 RQEMFP-------------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIR 338
             E F               +    +   F   DE  R          R G+T V   I 
Sbjct: 81  TNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMIS 140

Query: 339 GNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLS 398
              ++    GDS+ +L R GQ     + HKP    EK+RI+  GG V+     RVNGSL+
Sbjct: 141 PKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVM---IQRVNGSLA 197

Query: 399 VSRAIGDAEHKPYICGDADSASTVLDGTE------------DYLILACDGFYDTVNPDEA 446
           VSRA+GD ++K   C D    +  L   E            +++ILACDG +D ++ +E 
Sbjct: 198 VSRALGDYDYK---CVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEEL 254

Query: 447 VKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTEN 506
            + V   L E + D   V + +V +    GS DN+++++V     + A  VS+E+   ++
Sbjct: 255 CEYVKSRL-EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVC---FSNAPKVSDEAVKKDS 310

Query: 507 SFQGGQEDGGDDKEN 521
                 E   + K N
Sbjct: 311 ELDKHLESRVEGKTN 325


>gi|122937199 protein phosphatase 1B-like [Homo sapiens]
          Length = 430

 Score =  102 bits (254), Expect = 1e-21
 Identities = 86/264 (32%), Positives = 124/264 (46%), Gaps = 23/264 (8%)

Query: 236 AIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHL--HV--N 291
           A +  R +MED H        L         A FAV DGHGG  AA + + HL  HV   
Sbjct: 71  AAQGWRARMEDAHCTWLSLPGL-----PPGWALFAVLDGHGGARAARFGARHLPGHVLQE 125

Query: 292 LVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQ 351
           L  +   P    EAL RAF   DER      R     G T VV  +    L++A  GDS+
Sbjct: 126 LGPEPSEPEGVREALRRAFLSADERLRSLWPRVETG-GCTAVVLLVSPRFLYLAHCGDSR 184

Query: 352 VMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK-- 409
            +L R G      + H+P R  E++RI A GG +      RV GSL+VSRA+GD  +K  
Sbjct: 185 AVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTI---RRRRVEGSLAVSRALGDFTYKEA 241

Query: 410 -------PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSS 462
                    +  + + A+      +++++LA DG +DTV+      +V+  L+       
Sbjct: 242 PGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPEL 301

Query: 463 MVAHKLVASARDAGSSDNITVIVV 486
           + A +L+ +    GS DN+T I+V
Sbjct: 302 LCA-QLLDTCLCKGSLDNMTCILV 324


>gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]
          Length = 324

 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 85/304 (27%), Positives = 135/304 (44%), Gaps = 36/304 (11%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +            E  ++FAV+DGH G   A Y   HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAVIGLP-----SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHIT 80

Query: 294 RQEMFP--------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIRGNMLH 343
             + F          +    +   F   DE  R + +    + R G+T V   I     +
Sbjct: 81  NNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTY 140

Query: 344 VAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAI 403
               GDS+ +L R  +     + HKP    EK+RI+  GG V+     RVNGSL+VSRA+
Sbjct: 141 FINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAVSRAL 197

Query: 404 GDAEHKPYICGDADSASTV-----------LDGTEDYLILACDGFYDTVNPDEAVKVVSD 452
           GD ++K  + G   +   V            +  + ++ILACDG +D +  +E    V  
Sbjct: 198 GDFDYK-CVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRS 256

Query: 453 HLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNK----AVNVSEESD-WTENS 507
            L E   D   V +++V +    GS DN++VI++   +  K    AV    E D + E  
Sbjct: 257 RL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECR 315

Query: 508 FQGG 511
            +GG
Sbjct: 316 VEGG 319


>gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]
          Length = 382

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 77/274 (28%), Positives = 124/274 (45%), Gaps = 31/274 (11%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +            E  ++FAV+DGH G   A Y   HL  ++ 
Sbjct: 26  LSSMQGWRVEMEDAHTAVIGLP-----SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHIT 80

Query: 294 RQEMFP--------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIRGNMLH 343
             + F          +    +   F   DE  R + +    + R G+T V   I     +
Sbjct: 81  NNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTY 140

Query: 344 VAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAI 403
               GDS+ +L R  +     + HKP    EK+RI+  GG V+     RVNGSL+VSRA+
Sbjct: 141 FINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAVSRAL 197

Query: 404 GDAEHKPYICGDADSASTV-----------LDGTEDYLILACDGFYDTVNPDEAVKVVSD 452
           GD ++K  + G   +   V            +  + ++ILACDG +D +  +E    V  
Sbjct: 198 GDFDYK-CVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRS 256

Query: 453 HLKENNGDSSMVAHKLVASARDAGSSDNITVIVV 486
            L E   D   V +++V +    GS DN++VI++
Sbjct: 257 RL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILI 289


>gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
          Length = 455

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 77/274 (28%), Positives = 124/274 (45%), Gaps = 31/274 (11%)

Query: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
           + +++  R +MED H  +            E  ++FAV+DGH G   A Y   HL  ++ 
Sbjct: 99  LSSMQGWRVEMEDAHTAVIGLP-----SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHIT 153

Query: 294 RQEMFP--------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIRGNMLH 343
             + F          +    +   F   DE  R + +    + R G+T V   I     +
Sbjct: 154 NNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTY 213

Query: 344 VAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAI 403
               GDS+ +L R  +     + HKP    EK+RI+  GG V+     RVNGSL+VSRA+
Sbjct: 214 FINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAVSRAL 270

Query: 404 GDAEHKPYICGDADSASTV-----------LDGTEDYLILACDGFYDTVNPDEAVKVVSD 452
           GD ++K  + G   +   V            +  + ++ILACDG +D +  +E    V  
Sbjct: 271 GDFDYK-CVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRS 329

Query: 453 HLKENNGDSSMVAHKLVASARDAGSSDNITVIVV 486
            L E   D   V +++V +    GS DN++VI++
Sbjct: 330 RL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILI 362


>gi|4505999 protein phosphatase 1G [Homo sapiens]
          Length = 546

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 27/216 (12%)

Query: 329 GTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWF 388
           GTT VV  IRG  L VA  GDS+ ++   G+A+++   HKP+ E E  RI+  GG V   
Sbjct: 328 GTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD 387

Query: 389 GAWRVNGSLSVSRAIGDAEHK---------PYICGDADSASTVLDGTEDYLILACDGFYD 439
           G  RVNG L++SRAIGD  +K           I    D     L    +++++ACDG ++
Sbjct: 388 G--RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWN 445

Query: 440 TVNPDEAVKVVSDHL--KENNGD----SSMVAHKL-----VASARDAGSSDNITVIVVFL 488
            ++  E V  +   +  ++ NG+    SS+V   L       ++ D    DN+T I++  
Sbjct: 446 VMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF 505

Query: 489 RDMNKAVNVSEESDWTE----NSFQGGQEDGGDDKE 520
           +  N A  +  ES   +     S +G +E+G  DK+
Sbjct: 506 KPRNTA-ELQPESGKRKLEEVLSTEGAEENGNSDKK 540



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 9/102 (8%)

Query: 226 PQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYAS 285
           P+L       A++  R  MED H CIP+ +         E A F+V+DGHGG + A+Y +
Sbjct: 21  PRLPLPYGFSAMQGWRVSMEDAHNCIPELD--------SETAMFSVYDGHGGEEVALYCA 72

Query: 286 IHLHVNLVRQEMFPHDPAE-ALCRAFRVTDERFVQKAARESL 326
            +L   +  Q+ +     + AL  AF   D +   +   + L
Sbjct: 73  KYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKEL 114



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 33/108 (30%), Positives = 43/108 (39%), Gaps = 16/108 (14%)

Query: 6   PEEKTYRRFLELFLGEFRGPCGGGEPEPE-PEPEPEPEPESEPEPEPELV--------EA 56
           P  K Y  F        RG   G   EP  P  E  P   S  +  P +         E 
Sbjct: 206 PTAKAYTGFSS---NSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSED 262

Query: 57  EAAEASVEEPGEEAATVA----ATEEGDQEQDPEPEEEAAVEGEEEEE 100
           E+ EA  EE   E  +      ++EE + E+D +  EEA  + EEEEE
Sbjct: 263 ESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEE 310



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 28/77 (36%), Positives = 33/77 (42%), Gaps = 5/77 (6%)

Query: 34  EPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAV 93
           E   +   E E E E   E  E E   +S E   EE      TEE  +E D E EEE  V
Sbjct: 258 EDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDED--DTEEA-EEDDEEEEEEMMV 314

Query: 94  EGEE--EEEGAATAAAA 108
            G E  EE G+ +   A
Sbjct: 315 PGMEGKEEPGSDSGTTA 331


>gi|29826282 protein phosphatase 1G [Homo sapiens]
          Length = 546

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 27/216 (12%)

Query: 329 GTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWF 388
           GTT VV  IRG  L VA  GDS+ ++   G+A+++   HKP+ E E  RI+  GG V   
Sbjct: 328 GTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD 387

Query: 389 GAWRVNGSLSVSRAIGDAEHK---------PYICGDADSASTVLDGTEDYLILACDGFYD 439
           G  RVNG L++SRAIGD  +K           I    D     L    +++++ACDG ++
Sbjct: 388 G--RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWN 445

Query: 440 TVNPDEAVKVVSDHL--KENNGD----SSMVAHKL-----VASARDAGSSDNITVIVVFL 488
            ++  E V  +   +  ++ NG+    SS+V   L       ++ D    DN+T I++  
Sbjct: 446 VMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF 505

Query: 489 RDMNKAVNVSEESDWTE----NSFQGGQEDGGDDKE 520
           +  N A  +  ES   +     S +G +E+G  DK+
Sbjct: 506 KPRNTA-ELQPESGKRKLEEVLSTEGAEENGNSDKK 540



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 9/102 (8%)

Query: 226 PQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYAS 285
           P+L       A++  R  MED H CIP+ +         E A F+V+DGHGG + A+Y +
Sbjct: 21  PRLPLPYGFSAMQGWRVSMEDAHNCIPELD--------SETAMFSVYDGHGGEEVALYCA 72

Query: 286 IHLHVNLVRQEMFPHDPAE-ALCRAFRVTDERFVQKAARESL 326
            +L   +  Q+ +     + AL  AF   D +   +   + L
Sbjct: 73  KYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKEL 114



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 33/108 (30%), Positives = 43/108 (39%), Gaps = 16/108 (14%)

Query: 6   PEEKTYRRFLELFLGEFRGPCGGGEPEPE-PEPEPEPEPESEPEPEPELV--------EA 56
           P  K Y  F        RG   G   EP  P  E  P   S  +  P +         E 
Sbjct: 206 PTAKAYTGFSS---NSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSED 262

Query: 57  EAAEASVEEPGEEAATVA----ATEEGDQEQDPEPEEEAAVEGEEEEE 100
           E+ EA  EE   E  +      ++EE + E+D +  EEA  + EEEEE
Sbjct: 263 ESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEE 310



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 28/77 (36%), Positives = 33/77 (42%), Gaps = 5/77 (6%)

Query: 34  EPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAV 93
           E   +   E E E E   E  E E   +S E   EE      TEE  +E D E EEE  V
Sbjct: 258 EDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDED--DTEEA-EEDDEEEEEEMMV 314

Query: 94  EGEE--EEEGAATAAAA 108
            G E  EE G+ +   A
Sbjct: 315 PGMEGKEEPGSDSGTTA 331


>gi|4505997 protein phosphatase 1D [Homo sapiens]
          Length = 605

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 82/275 (29%), Positives = 126/275 (45%), Gaps = 55/275 (20%)

Query: 267 AYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFR---VTDERFVQKAAR 323
           A+FAV DGHGG +AA +A  HL   + +Q+ F       +C A R   +     + K   
Sbjct: 99  AFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLA 158

Query: 324 E--------SLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKG-------QAVELMKPHK 368
           E            GTT  V  IRG  ++VA VGDS V+L  +        +AVE+ + HK
Sbjct: 159 EWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHK 218

Query: 369 PDREDEKQRIEALGGCVV-WFGAWRV---------NGS------------LSVSRAIGDA 406
           P+   E++RIE LGG V+   G  RV         NG             L+V+RA+GD 
Sbjct: 219 PELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDL 278

Query: 407 EHKPYICG------DADSASTVLDGTE-DYLILACDGFYDTVNPDEAVKVVSD-----HL 454
               +  G      + D++   LD  +  Y+IL  DG ++ + P +A+ +  D     +L
Sbjct: 279 WSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYL 338

Query: 455 KENNGDS--SMVAHKLVASARDAG-SSDNITVIVV 486
              +G S   M+ ++ +   R     +DN + IV+
Sbjct: 339 MGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVI 373


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 46/113 (40%), Positives = 52/113 (46%), Gaps = 9/113 (7%)

Query: 32  EPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATE---EGDQEQDPEPE 88
           E  PEP PEP PE  P P PE   +E+A     EP  E AT  A+E   E   E  PEP 
Sbjct: 48  EASPEPIPEPCPELAPGPCPE-ATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPA 106

Query: 89  EEAAVE--GEEEEEGAATAAAAPGHSAVPPPPPQLPP--LPPL-PRPLSERIT 136
            E A E   E   E A      P   +VP P P+L P   P L P P  E +T
Sbjct: 107 TEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVT 159



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 42/112 (37%), Positives = 48/112 (42%), Gaps = 11/112 (9%)

Query: 31  PEPEPEPEPE----PEPESEPEPEPELVEAEAAEASVE---EPGEEAATVAATEEGDQEQ 83
           PEP PEP PE    P PE+  E   EL      E + E   EP  E AT  A E    E 
Sbjct: 51  PEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPA-TEP 109

Query: 84  DPEPEEEAAVEG--EEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSE 133
            PEP  E A E   E   E A  +   P     P   P+L P  P P P++E
Sbjct: 110 APEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAP-EPTPEPVTE 160



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 39/109 (35%), Positives = 41/109 (37%), Gaps = 22/109 (20%)

Query: 25  PCGGGEPEP--------------EPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEA 70
           PC    P P              EP PEP  EP SEP PEP     E A     EP  E 
Sbjct: 57  PCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEP---ATEPAPEPATEPAPEP 113

Query: 71  ATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPP 119
           A   ATE       PEP  E A+E   E     T   AP  +  P P P
Sbjct: 114 APEPATESA-----PEPTPEPALESVPEPAPELTPEVAPELAPEPTPEP 157



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 43/130 (33%), Positives = 49/130 (37%), Gaps = 22/130 (16%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPELVEA---------EAAEASVEEPGEEAATVAATEEGD 80
           EP PEP  EP PEP +EP PEP    A         E A  SV EP  E     A E   
Sbjct: 92  EPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELA- 150

Query: 81  QEQDPEPEEEAAVEGEEEEEGAATAAAAP------------GHSAVPPPPPQLPPLPPLP 128
            E  PEP  E A E   E       + AP            G    P P P   P  P+ 
Sbjct: 151 PEPTPEPVTELAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTPMS 210

Query: 129 RPLSERITRE 138
               ++I +E
Sbjct: 211 WSRIKKILKE 220



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 40/116 (34%), Positives = 47/116 (40%), Gaps = 16/116 (13%)

Query: 25  PCGGGEPEPEPEPEPE---PEPESEPEPEPELVEAEAAEASVEEPGEEAA---TVAATEE 78
           P  G +P   PEP P    P P   P P P L+ +EA+   + EP  E A      AT E
Sbjct: 14  PQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLL-SEASPEPIPEPCPELAPGPCPEATSE 72

Query: 79  GDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLP-PLPRPLSE 133
              E   EP  E A E   E         AP  +  P P P   P P P P P +E
Sbjct: 73  SATELYTEPTPEPATEPASE--------PAPEPATEPAPEPATEPAPEPAPEPATE 120



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 8/51 (15%)

Query: 91  AAVEGE---EEEEGAATAAAAPGHSAVPPPPPQLPPLPPL-----PRPLSE 133
           AA +G    ++ E  A +   P     PPPPP  PP PPL     P P+ E
Sbjct: 6   AAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPE 56


>gi|37221175 PH domain and leucine rich repeat protein phosphatase
           [Homo sapiens]
          Length = 1205

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/231 (24%), Positives = 96/231 (41%), Gaps = 19/231 (8%)

Query: 266 QAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARES 325
           +A + VFDG   V+        +   L  +     +  E +   F V      +K     
Sbjct: 691 EALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQ----RKLGTAG 746

Query: 326 LRCGTTGVVTFIRGN--------MLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQR 377
            + G   V+  I+ +         L  A VG  Q +L R G+ + L + +    E+E +R
Sbjct: 747 QKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKR 806

Query: 378 IEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGF 437
           I+     +   G  +VNG    +R +G     P +       S +L   +++ IL   G 
Sbjct: 807 IKQHKAIITEDG--KVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGL 864

Query: 438 YDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFL 488
           +D+++ +EAV+ V      N  D+   A KL   A+  G  D+I+ +VV L
Sbjct: 865 WDSLSVEEAVEAV-----RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQL 910



 Score = 30.0 bits (66), Expect = 8.3
 Identities = 25/81 (30%), Positives = 32/81 (39%), Gaps = 9/81 (11%)

Query: 47   PEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQ-DPEPEEEAAVEGEEEEEGAATA 105
            P+     V   A +A + +PG   A  A  +  DQ    PE EEE     +  +E     
Sbjct: 1117 PQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQ--- 1173

Query: 106  AAAPGHSAVPPPPPQLPPLPP 126
                     PPPPPQL P  P
Sbjct: 1174 -----QQQQPPPPPQLQPQLP 1189


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 39/102 (38%), Positives = 45/102 (44%), Gaps = 1/102 (0%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEE 89
           E E E E E E E E E + E E  + E      EE  EE       EEG+ E++ E E+
Sbjct: 891 EEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEED 950

Query: 90  EAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPP-LPPLPRP 130
           E   E  EE E      A        PPPP LPP LPP   P
Sbjct: 951 EEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESP 992



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 52/180 (28%), Positives = 67/180 (37%), Gaps = 26/180 (14%)

Query: 7    EEKTYRRFLELFLGEFRGPCGGGEPEPE------PEPEPEPEPESEPEPEPELVEAEAAE 60
            EE+      +L  G   G    G P P       P PE  P+ + EPEPEP L+      
Sbjct: 953  EEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLL------ 1006

Query: 61   ASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQ 120
              VEEPG E       E G         E    +GE E EG + AA  P    V   P  
Sbjct: 1007 LEVEEPGTE------EERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSA 1060

Query: 121  LPPL--------PPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDE 172
             P L            +P  E    EE+E E+    LQ+  + +  + LA  +     DE
Sbjct: 1061 PPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDE 1120



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/165 (26%), Positives = 53/165 (32%), Gaps = 58/165 (35%)

Query: 24   GPCGGGEPEPEPEPEP------------------------------------EPEPESEP 47
            GP     P P P P P                                    E E E E 
Sbjct: 837  GPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEE 896

Query: 48   EPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEE------- 100
            E E E  E E  +   EE  EE       EE ++ ++   EEE  +E EEEEE       
Sbjct: 897  EEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEE 956

Query: 101  ------------GAATAAAAPGHSAVPP--PPPQLPP-LPPLPRP 130
                        G      AP    +PP  PPP+ PP + P P P
Sbjct: 957  LEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEP 1001



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 39/129 (30%), Positives = 46/129 (35%), Gaps = 35/129 (27%)

Query: 30   EPEPEPEP-------EPEPEPESEPEPEPELV-EAEAAEASVEEPGEEAAT--------- 72
            +PEPEPEP       EP  E E   +  P L  EA  ++  VE  GE  A          
Sbjct: 996  QPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVE 1055

Query: 73   ----------VAATEEGDQEQDPEPEEEAAVEGEEEEEGAA--------TAAAAPGHSAV 114
                         TE+G  +  P PE  A  E E E E  A        TAA        
Sbjct: 1056 EEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDC 1115

Query: 115  PPPPPQLPP 123
            PP   + PP
Sbjct: 1116 PPDDEKPPP 1124



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 38/135 (28%), Positives = 50/135 (37%), Gaps = 45/135 (33%)

Query: 31   PEPEPEPEPEP-------EPESEPE-------------------------------PEPE 52
            P+ +PEPEPEP       EP +E E                               P  E
Sbjct: 993  PKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQE 1052

Query: 53   LVEAE--AAEASVEEPGEEAA-TVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAA-- 107
            LVE E  A    +EE  E+ +  V    E   E++ E E EA    E+E++  A   A  
Sbjct: 1053 LVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADF 1112

Query: 108  --APGHSAVPPPPPQ 120
               P     PPPP +
Sbjct: 1113 IDCPPDDEKPPPPTE 1127



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 38/130 (29%), Positives = 48/130 (36%), Gaps = 33/130 (25%)

Query: 28  GGEPEPEPEPEPEPEPESEPE-------PEPELVEAEAAEASVEEPGEEAAT---VAATE 77
           G   +P   P   P P   P+       P P  V  +  EAS  E   E+ +   V    
Sbjct: 733 GSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVP 792

Query: 78  EGDQEQDPEPEEEAA---------------VEGEEEEEGAATAAAAPGHSAVPPPPPQLP 122
           EG     P P   A                V  +EE E      AAPG   +PPPPP   
Sbjct: 793 EGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPE---ELPAAPG--PLPPPPP--- 844

Query: 123 PLPPLPRPLS 132
           P PP+P P++
Sbjct: 845 PPPPVPGPVT 854


>gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3
           [Homo sapiens]
          Length = 2059

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 32/82 (39%), Positives = 39/82 (47%), Gaps = 15/82 (18%)

Query: 64  EEPGEEAATVAATEEGDQEQDPEPEEE---AAVEGEEEEEGAATAAAAPGHSA------- 113
           EE  EE   V+  EE ++E+  E EEE   AA E +EE++        PGH         
Sbjct: 8   EEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSP 67

Query: 114 -----VPPPPPQLPPLPPLPRP 130
                 PPPPP  PPLPP P P
Sbjct: 68  PGCHLFPPPPPPPPPLPPPPPP 89



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 4/106 (3%)

Query: 31   PEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEE 90
            P+P  + +      S  +  P   EA A  +       + AT A +E+G+  + P  +EE
Sbjct: 1578 PDPSADSKRSSRASSPTKTSPTTPEASATNSPCTS---KPATPAPSEKGEGIRTPLEKEE 1634

Query: 91   AAVEGEEEEEGAATAAAAPGHSAVPPPPPQL-PPLPPLPRPLSERI 135
            A  + E+ E+ +         +  P P P L   L P   PL + +
Sbjct: 1635 AENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDEV 1680



 Score = 30.0 bits (66), Expect = 8.3
 Identities = 22/76 (28%), Positives = 31/76 (40%), Gaps = 4/76 (5%)

Query: 29   GEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASV--EEPGEEAATVAATEE--GDQEQD 84
            GE EPEP    + E  +      E  E +  +     E P  E   +   E+  GD+E  
Sbjct: 1685 GEMEPEPGYRGDREKSATESTPGERGEEKPLDGQEHRERPEGETGDLGKREDVKGDRELR 1744

Query: 85   PEPEEEAAVEGEEEEE 100
            P P +E    G  EE+
Sbjct: 1745 PGPRDEPRSNGRREEK 1760


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 42/123 (34%), Positives = 52/123 (42%), Gaps = 7/123 (5%)

Query: 29   GEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQE----QD 84
            GE +PE E    PE E E +PE E VEA+ AE   +   E      A EE   E    + 
Sbjct: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182

Query: 85   PEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPP---LPRPLSERITREEVE 141
            PE E EA  E E  E   A   A P    V  P  +    P    +  P +E   + E E
Sbjct: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESE 2242

Query: 142  GES 144
            GE+
Sbjct: 2243 GET 2245



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 39/122 (31%), Positives = 51/122 (41%), Gaps = 6/122 (4%)

Query: 29   GEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQ----- 83
            GE +PE E    PE E E +PE E VE   AE  V+   E A    A +E   E      
Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924

Query: 84   -DPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEG 142
             + E E+E   EG E +E    A  A G +       +        +P SE +   EVE 
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984

Query: 143  ES 144
            E+
Sbjct: 1985 ET 1986



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 12/101 (11%)

Query: 31   PEPEPEPEPEPE----PESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPE 86
            PE E E +PE E    PE+E E +PEL   EA EA  E   E         EG+ + + E
Sbjct: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESE 2242

Query: 87   PEEEAAVEGE--------EEEEGAATAAAAPGHSAVPPPPP 119
             E +   +G         + EE + +++  P     PPP P
Sbjct: 2243 GETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP 2283



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 23/139 (16%)

Query: 27   GGGEPEPEPEPEPEPEP----ESEPEPEPELVEAEAAEASVEEPGEEA-------ATVAA 75
            G   PE E E +PE E     E+E E EPE   AEA EA  EE  +EA       + V  
Sbjct: 1905 GAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEA--EEAAQEAEGQTQPESEVIE 1962

Query: 76   TEEGDQEQDPEPEEEAAVEGE---EEEEGAA-------TAAAAPGHSAVPPPPPQLPPLP 125
            ++E ++E  PE E+  A+E E   +E EG A        A  A G         Q     
Sbjct: 1963 SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG 2022

Query: 126  PLPRPLSERITREEVEGES 144
               +P SE    +EVEGE+
Sbjct: 2023 VEAQPKSEGEEAQEVEGET 2041



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 35/120 (29%), Positives = 50/120 (41%), Gaps = 2/120 (1%)

Query: 27   GGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATV-AATEEGDQEQDP 85
            G  +PE E    PE E E +   E    E++  EA  +  GEEA  V   T++ + +  P
Sbjct: 1991 GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQP 2050

Query: 86   EPEEEAAVEGEEE-EEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGES 144
            E +   A E EEE +E       A G +                +P SE +   E EGE+
Sbjct: 2051 ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEA 2110



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 37/120 (30%), Positives = 48/120 (40%), Gaps = 14/120 (11%)

Query: 28   GGEPEPEPEPEPE----PEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQ 83
            GG+ +P      E    PE E E +PE E VEA  AE   +E   E     A  E +  +
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGE-----AQPESEDVE 1875

Query: 84   DPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGE 143
             PE E EA  E E+ E   A     P       P  +        +P +E +   E EGE
Sbjct: 1876 APEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKE-----AQPETESVEALETEGE 1930



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 48/180 (26%), Positives = 67/180 (37%), Gaps = 10/180 (5%)

Query: 20   GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
            G+  G  G   PE E E +PE E    PE E +  EAE  EA  E    EA       E 
Sbjct: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE-GEAQPESEDVEA------PEA 1879

Query: 80   DQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREE 139
            + E  PE E+    E E E +  +  A AP   A     P+   +  L     +    E 
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAP--EAEKEAQPETESVEALETEGEDEPESEG 1937

Query: 140  VEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQS-DLSAHYIPKETDGTEGTVEIET 198
             E +  +   Q+      P         A  +   +S D+ A  +  ET   EG  + E+
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 42/131 (32%), Positives = 51/131 (38%), Gaps = 32/131 (24%)

Query: 29   GEPEPEPE----PEPE-----------PEPESEPEPEPELVEAEAAEASVEEPGEEAATV 73
            GE +PE E    PE E           PE E E +PE E +EA  AE   +   E     
Sbjct: 2092 GEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE----- 2146

Query: 74   AATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSE 133
               E  D E + +PE E     E EEE      A P    V     + P      +P SE
Sbjct: 2147 -GVEAQDAEGEAQPESEGIEAQEAEEE------AQPELEGV-----EAPEAEGEAQPESE 2194

Query: 134  RITREEVEGES 144
             I   E EGE+
Sbjct: 2195 GIEAPEAEGEA 2205



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/127 (27%), Positives = 52/127 (40%), Gaps = 2/127 (1%)

Query: 20   GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVE-EPGEEAATVAATE- 77
            GE      G   + E + +PE +    PE E E  EAE      E E   E+  V A E 
Sbjct: 2031 GEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEA 2090

Query: 78   EGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITR 137
            EG+ + + E  E    EGE ++     A    G +       + P      +P SE +  
Sbjct: 2091 EGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEA 2150

Query: 138  EEVEGES 144
            ++ EGE+
Sbjct: 2151 QDAEGEA 2157



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/132 (28%), Positives = 53/132 (40%), Gaps = 19/132 (14%)

Query: 30   EPEPEPEPEPEP-----------EPESEPEPEPELVEAEAAEASVEEPGEEA------AT 72
            E E E +PE E            E E E +PE E VEA  AE  ++E  EEA        
Sbjct: 1965 EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE 2024

Query: 73   VAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLS 132
                 EG++ Q+ E E +   EG+ + E     A      A      ++        P S
Sbjct: 2025 AQPKSEGEEAQEVEGETQ-KTEGDAQPESDGVEAPEAEEEA-QEAEGEVQEAEGEAHPES 2082

Query: 133  ERITREEVEGES 144
            E +  +E EGE+
Sbjct: 2083 EDVDAQEAEGEA 2094



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 37/114 (32%), Positives = 46/114 (40%), Gaps = 25/114 (21%)

Query: 5    IPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVE 64
            IPEE     + EL   E  G  GGG   PE +P  +   E   EP      A+A + S+E
Sbjct: 964  IPEEPILMTY-EL-ADETTGAAGGGLRGPEVDPGDDHSLEGLGEP------AQAGQQSLE 1015

Query: 65   EPGEEAATVAATEEGDQEQDPEPEEE---AAVEGEEEEEGAATAAAAPGHSAVP 115
                          GD  QDPEPE     ++  G +  EG    AA  G S  P
Sbjct: 1016 --------------GDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAP 1055



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 24/88 (27%), Positives = 33/88 (37%), Gaps = 13/88 (14%)

Query: 30   EPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATV--AATEEGDQEQDPEP 87
            +PEPE    PE E E++PE E         E   E+ G    ++    +EE  +   P P
Sbjct: 2222 QPEPEGVETPEAEGEAQPESE--------GETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273

Query: 88   EEEAAVEGEEEEEGAATAAAAPGHSAVP 115
            E+           G  T    PG    P
Sbjct: 2274 EDRPT---PPPSPGGDTPHQRPGSQTGP 2298


>gi|156523246 proline-rich transmembrane protein 2 [Homo sapiens]
          Length = 340

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 31/99 (31%), Positives = 41/99 (41%), Gaps = 22/99 (22%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEE 89
           EP PEP P+P+P P+S+P P+P L                        E   ++DP PE 
Sbjct: 133 EPAPEPAPQPDPRPDSQPTPKPAL----------------------QPELPTQEDPTPEI 170

Query: 90  EAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLP 128
            +   GE++E GA     A      P P P  PP    P
Sbjct: 171 LSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSP 209



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 30/118 (25%), Positives = 48/118 (40%), Gaps = 7/118 (5%)

Query: 33  PEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATE-----EGDQEQDPEP 87
           P+    P+P P +   P     +A  A  + E P   + T  AT+      G+ + +  P
Sbjct: 42  PDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSP 101

Query: 88  EE--EAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGE 143
           E+  +  V   E  + A     +   SA PP P   P   P PRP S+   +  ++ E
Sbjct: 102 EDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPE 159



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 32/118 (27%), Positives = 44/118 (37%), Gaps = 19/118 (16%)

Query: 29  GEPEPEPEPEPEPEPESEPEPE-------PELVEAEAAEASVEE-------PGEEAATVA 74
           G P+    P+P P   + P          PE  E  A  +   +       PG E+    
Sbjct: 40  GVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANC 99

Query: 75  ATEEGDQE--QDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRP 130
           + E+  QE    PE  +EA  +     E AA    AP     P P P+ P   P P+P
Sbjct: 100 SPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAP--EPAPQPDPR-PDSQPTPKP 154


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 39/88 (44%), Positives = 43/88 (48%), Gaps = 7/88 (7%)

Query: 20   GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
            GE+ G    GE E E E E E E E E E E E  E E  E   EE GEE        EG
Sbjct: 953  GEWEGEEEEGEGEGEEEGEGEGE-EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG 1011

Query: 80   DQEQDPEPEEEAAVEGE------EEEEG 101
            + E++ E E E  VEGE      EEEEG
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEG 1039



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 40/90 (44%), Positives = 44/90 (48%), Gaps = 15/90 (16%)

Query: 20   GEFRGPCGGGEPEPEP------EPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATV 73
            GE  G  G GE E E       E E E E E E E E E  E E  E   E  GEE    
Sbjct: 937  GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE---- 992

Query: 74   AATEEGDQE--QDPEPEEEAAVEGEEEEEG 101
               EEG++E  ++ E EEE   EGEEEEEG
Sbjct: 993  ---EEGEEEGEEEGEGEEEGEGEGEEEEEG 1019



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 33/76 (43%), Positives = 37/76 (48%), Gaps = 2/76 (2%)

Query: 27   GGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPE 86
            G GE E E E E E E E E E E E  E E  E   EE GEE       EE  + ++ E
Sbjct: 1003 GEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEE 1062

Query: 87   PEEEAAVE--GEEEEE 100
             EEE   +  GEEE E
Sbjct: 1063 EEEEGKYQETGEEENE 1078



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 37/88 (42%), Positives = 40/88 (45%), Gaps = 7/88 (7%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
           GE  G  G GE E E E E E E E E E E E  E E  E    E  EE       EEG
Sbjct: 867 GEEEGEEGEGEGEEE-EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925

Query: 80  DQEQDPEPEEEAAVEGE------EEEEG 101
           ++ +    EEE   EGE      EEEEG
Sbjct: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEEG 953



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 33/78 (42%), Positives = 36/78 (46%), Gaps = 5/78 (6%)

Query: 27  GGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGD-----Q 81
           G GE E E E     E E E E E    E E  E   EE GEE       EEG+     +
Sbjct: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881

Query: 82  EQDPEPEEEAAVEGEEEE 99
           E + E EEE   EGEEEE
Sbjct: 882 EGEGEGEEEGEGEGEEEE 899



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 37/98 (37%), Positives = 40/98 (40%), Gaps = 10/98 (10%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEP-------EPEPELVEAEAAEASVEEPGEEAAT 72
           GE  G   G E E E E E E E E E        E E E  E E  E   E  GE+   
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946

Query: 73  VAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPG 110
               EEG+ E +   EEE   EGEEE EG        G
Sbjct: 947 EGEEEEGEWEGE---EEEGEGEGEEEGEGEGEEGEGEG 981



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 29/74 (39%), Positives = 35/74 (47%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           G E E + E E E E E + E E E VE E  +   E   EE A      E + +Q    
Sbjct: 738 GEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGE 797

Query: 88  EEEAAVEGEEEEEG 101
           EEE    GEE+EEG
Sbjct: 798 EEETEGRGEEKEEG 811



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 32/78 (41%), Positives = 34/78 (43%), Gaps = 5/78 (6%)

Query: 29  GEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPE-- 86
           GE E E     E E E E E      E E  E   EE GEE       EEG+ E + E  
Sbjct: 833 GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGE 892

Query: 87  ---PEEEAAVEGEEEEEG 101
               EEE   EGEEE EG
Sbjct: 893 GEGEEEEGEGEGEEEGEG 910



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 35/83 (42%), Positives = 38/83 (45%), Gaps = 2/83 (2%)

Query: 20   GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
            GE  G    GE E E       E E E E E E  E E  E   E  GEE       EEG
Sbjct: 928  GEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG-EGEGEEGEGEGEEEEG 986

Query: 80   DQE-QDPEPEEEAAVEGEEEEEG 101
            + E ++ E EEE   EGE EEEG
Sbjct: 987  EGEGEEEEGEEEGEEEGEGEEEG 1009



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 33/81 (40%), Positives = 37/81 (45%), Gaps = 7/81 (8%)

Query: 27   GGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPE 86
            G GE E E E E E E E E E E E  E E  E   E  GEE       EEG++E +  
Sbjct: 988  GEGEEE-EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER 1046

Query: 87   PEEEAAVEG------EEEEEG 101
             +E    E       EEEEEG
Sbjct: 1047 EKEGEGEENRRNREEEEEEEG 1067



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/80 (33%), Positives = 37/80 (46%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
           GE   P  G +   E E   + + E + + E E    +     +EE GEE       EEG
Sbjct: 684 GEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG 743

Query: 80  DQEQDPEPEEEAAVEGEEEE 99
           D+E++ E E E   EGE EE
Sbjct: 744 DREEEEEKEGEGKEEGEGEE 763



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 39/89 (43%), Positives = 41/89 (46%), Gaps = 10/89 (11%)

Query: 20  GEFRGPCGGGEPEPEPE-----PEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVA 74
           GE  G    GE E E E      E E E E E E E E  E E  E   EE GEE     
Sbjct: 874 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE-GEEEEGEGKGEEEGEEGEGEG 932

Query: 75  ATEEGDQE-QDPE---PEEEAAVEGEEEE 99
             EEG+ E +D E    EEE   EGEEEE
Sbjct: 933 EEEEGEGEGEDGEGEGEEEEGEWEGEEEE 961



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/96 (40%), Positives = 41/96 (42%), Gaps = 13/96 (13%)

Query: 27  GGGEPEPEPEPEPEP-EPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQE-QD 84
           G GE E E E E E  E E E E E E  E E  E   EE GEE       EEG+ E +D
Sbjct: 885 GEGEEEGEGEGEEEEGEGEGEEEGEGE-GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGED 943

Query: 85  PEPE----------EEAAVEGEEEEEGAATAAAAPG 110
            E E          EE   EGE EEEG        G
Sbjct: 944 GEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 33/81 (40%), Positives = 35/81 (43%), Gaps = 4/81 (4%)

Query: 24  GPCGGGEPEPEPEPEPEPEPESEPEPEP---ELVEAEAAEASVEEPGEEAATVAATEEGD 80
           G   GGE E       E E E E E E    E  E E  E   E  GEE       EE  
Sbjct: 812 GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG 871

Query: 81  QEQDPEPEEEAAVEGEEEEEG 101
           +E + E EEE   EGE EEEG
Sbjct: 872 EEGEGEGEEEEG-EGEGEEEG 891



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 36/84 (42%), Positives = 39/84 (46%), Gaps = 3/84 (3%)

Query: 20   GEFRGPCGGGEPEPEP-EPEPEPEP-ESEPEPEPELVEAEAAEASVEEPGEEAATVAATE 77
            GE  G  G GE E E  E E E E  E E E E E  E    E   EE GE    V   E
Sbjct: 970  GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG-E 1028

Query: 78   EGDQEQDPEPEEEAAVEGEEEEEG 101
            EG+ E + E  EE   E E+E EG
Sbjct: 1029 EGEGEGEEEEGEEEGEEREKEGEG 1052



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/79 (41%), Positives = 38/79 (48%), Gaps = 7/79 (8%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEE-----GDQE 82
           G E E E + E E E E E E E E  E E  E   E  GEE       EE     G++E
Sbjct: 849 GEEEEGEGKGEEEGE-EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907

Query: 83  QDPEPEEEAAVEGEEEEEG 101
            + E EEE   EG+ EEEG
Sbjct: 908 GEGEGEEEEG-EGKGEEEG 925



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 34/80 (42%), Positives = 38/80 (47%), Gaps = 6/80 (7%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
           GE  G  G GE E E E E E E + E E E E  E E  E   E  GEE        EG
Sbjct: 921 GEEEGEEGEGEGEEE-EGEGEGE-DGEGEGEEEEGEWEGEEEEGEGEGEEEGE----GEG 974

Query: 80  DQEQDPEPEEEAAVEGEEEE 99
           ++ +    EEE   EGEEEE
Sbjct: 975 EEGEGEGEEEEGEGEGEEEE 994



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 34/83 (40%), Positives = 39/83 (46%), Gaps = 4/83 (4%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
           GE  G   G E E E + E E E E E E E E  E E  +   E   EE       EEG
Sbjct: 904 GEEEGEGEGEEEEGEGKGEEEGE-EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962

Query: 80  DQE--QDPEPE-EEAAVEGEEEE 99
           + E  ++ E E EE   EGEEEE
Sbjct: 963 EGEGEEEGEGEGEEGEGEGEEEE 985



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 33/83 (39%), Positives = 38/83 (45%), Gaps = 5/83 (6%)

Query: 20  GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG 79
           GE  G  G GE E   E E   E E E   E E  E E  +   EE  EE        EG
Sbjct: 787 GEEEGDQGEGEEE---ETEGRGE-EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842

Query: 80  DQEQDPEPEEEAAVEGEEE-EEG 101
           ++E+    EEE   +GEEE EEG
Sbjct: 843 EEEEGEGEEEEGEGKGEEEGEEG 865



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 1/75 (1%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           G   + E E + E     E + E E  + E  E   E  GEE       E G+ E+    
Sbjct: 766 GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE 825

Query: 88  EEEAAVEGE-EEEEG 101
            EE   EGE EEEEG
Sbjct: 826 REEEEEEGEGEEEEG 840



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 26/74 (35%), Positives = 32/74 (43%), Gaps = 12/74 (16%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           GGE E     E E + E E E E         E   E  GEE       EEG++++    
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKE--------GEGKEEGEGEEVEGEREKEEGERKK---- 777

Query: 88  EEEAAVEGEEEEEG 101
           EE A  E + EEEG
Sbjct: 778 EERAGKEEKGEEEG 791



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 2/75 (2%)

Query: 29  GEPEPEPEPEPEPEPESEPEP-EPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           GE + E     E + E E +  E E  E E      EE GE         +G++E++ E 
Sbjct: 773 GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE 832

Query: 88  EEEAAVEGE-EEEEG 101
            E    EGE EEEEG
Sbjct: 833 GEGEEEEGEGEEEEG 847



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 27/74 (36%), Positives = 31/74 (41%), Gaps = 2/74 (2%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           G E E   E E     E + E E E  E E  E   E  GEE       EEG+ + + E 
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE--GEEEEGEGEEEEGEGKGEEEG 862

Query: 88  EEEAAVEGEEEEEG 101
           EE    E  EE EG
Sbjct: 863 EEGEGEEEGEEGEG 876



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 22/67 (32%), Positives = 29/67 (43%)

Query: 34  EPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAV 93
           E E   E E E   + E +  + E  E    E G +       EEG +E+  E EEE   
Sbjct: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 744

Query: 94  EGEEEEE 100
             EEEE+
Sbjct: 745 REEEEEK 751


>gi|222144283 hypothetical protein LOC65998 [Homo sapiens]
          Length = 678

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 40/106 (37%), Positives = 48/106 (45%), Gaps = 32/106 (30%)

Query: 41  PEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG--DQEQDPEPEEE-------- 90
           P PES   P P              PG    T AA++EG  D+E++PE EEE        
Sbjct: 493 PRPESPQGPIP--------------PG----TAAASDEGGGDEEEEPEEEEEEWGDVPLS 534

Query: 91  --AAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSER 134
             A +E   EEE        PG  A+PPPPP  PP PP PR   +R
Sbjct: 535 PGAPLERPAEEEEDEEDGQEPGGLALPPPPP--PPPPPPPRSREQR 578


>gi|110349786 Alstrom syndrome 1 [Homo sapiens]
          Length = 4169

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 50/176 (28%), Positives = 73/176 (41%), Gaps = 24/176 (13%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPE--- 86
           EPE  P P    E E E E E E  E EAA A+     +        EE  +E D +   
Sbjct: 2   EPEDLPWPGELEEEEEEEEEEEEEEEEEAAAAAAANVDDVVVVEEVEEEAGRELDSDSHY 61

Query: 87  -PEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLS--ERITREEVEGE 143
            P+   +++ EE+EE  A   A PG          LPPL P     S  ER + E++   
Sbjct: 62  GPQHLESIDDEEDEEAKAWLQAHPGRI--------LPPLSPPQHRYSEGERTSLEKIVPL 113

Query: 144 SLDLCLQQLYKYNCPS--------FLAAALARATSDEVLQSDLSAHYIPKETDGTE 191
           +  +  Q +Y+ N  +         L     R + D+  Q   S H +P+E D ++
Sbjct: 114 TCHVWQQIVYQGNSRTQISDTNVVCLETTAQRGSGDD--QKTESWHCLPQEMDSSQ 167


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 37/121 (30%), Positives = 49/121 (40%), Gaps = 18/121 (14%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPE-LVEAEAAEASVEEPGEEAATVAATEEGDQEQD---- 84
           +  P P P P   P   P  +PE +VEA +A  + EEP ++           +EQD    
Sbjct: 726 DQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMA 785

Query: 85  --PEPEEEAAVEGEEEEEG-----------AATAAAAPGHSAVPPPPPQLPPLPPLPRPL 131
             P PEE        E  G           AA++++A      PP  P  PP PP P P 
Sbjct: 786 DFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPA 845

Query: 132 S 132
           S
Sbjct: 846 S 846



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%)

Query: 33  PEPE-PEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDP-EPEEE 90
           P P+ P P   P S+P        A AA A V  PG  + T A+ +     Q    P +E
Sbjct: 662 PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVV--PGPVSTTDASPQSPPTPQTTLTPLQE 719

Query: 91  AAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVE 141
           + V  +++     +   +P  S  PPPPP   P   +  P +     E ++
Sbjct: 720 SPVISKDQ-----SPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQ 765



 Score = 30.0 bits (66), Expect = 8.3
 Identities = 31/118 (26%), Positives = 42/118 (35%), Gaps = 7/118 (5%)

Query: 35  PEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVE 94
           P+PE + +P+  P P P    +E A A+   P    + V     G   + P   E     
Sbjct: 523 PKPERKQQPQL-PRP-PTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580

Query: 95  GEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGESLDLCLQQL 152
                  + T    P   A PP  P     PP P    ER+T     G S+   L  L
Sbjct: 581 SSGYSSQSGTPTLPPKGLAGPPASPG-KAQPPKP----ERVTSLRSPGASVSSSLTSL 633


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 10/110 (9%)

Query: 35   PEPEPEP-----EPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEE 89
            PEP P P      P  E    PE+V AEA E   ++  ++       EEG++E + E EE
Sbjct: 1318 PEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREE--GEEEGEEEGEEEEEE 1375

Query: 90   EAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPL---PRPLSERIT 136
             +      + EGA    +   H+    PPP  PP PP    PR   E++T
Sbjct: 1376 SSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMT 1425



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 4/80 (5%)

Query: 47  PEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAA 106
           P P P   E  A   S    GE  AT  + +   Q Q         +E  +++ G +   
Sbjct: 541 PPPAPANFEDVAPTGS----GEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPP 596

Query: 107 AAPGHSAVPPPPPQLPPLPP 126
           A       PPPPP  PP PP
Sbjct: 597 APTPPQQPPPPPPPPPPPPP 616



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 32/123 (26%), Positives = 38/123 (30%), Gaps = 18/123 (14%)

Query: 33   PEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQE---QDPEPE- 88
            P P   P P P     P PE V         E+    A     TEE       + PEP  
Sbjct: 1079 PPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPA 1138

Query: 89   -EEAAVEGEEEEEGAATAAAAP--------GHSAV-----PPPPPQLPPLPPLPRPLSER 134
               A     +E   +      P          SA+     P PPP  PP    P P S +
Sbjct: 1139 GPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198

Query: 135  ITR 137
              R
Sbjct: 1199 APR 1201



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 32/146 (21%), Positives = 54/146 (36%), Gaps = 30/146 (20%)

Query: 20   GEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEA-ATVAATEE 78
            GE        E + E + E E + + E   +    E E ++   EE    +  ++ A  +
Sbjct: 965  GEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSD 1024

Query: 79   GDQEQDPEPE------------------------EEAAVEGEEEEEGAATAAAAPGHSAV 114
            G+ +   + E                        E ++ + EEEE  AA  +A+P    V
Sbjct: 1025 GENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREV 1084

Query: 115  PPPPPQLPPLPPLPRPLSERITREEV 140
            P P P      P+  P+ ER+    V
Sbjct: 1085 PVPTP-----APVEVPVPERVAGSPV 1105



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 3/73 (4%)

Query: 31  PEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGD---QEQDPEP 87
           P  E E +PE E E+     P     +  E   +  G+   + A   EG+   QE   E 
Sbjct: 917 PAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEK 976

Query: 88  EEEAAVEGEEEEE 100
           +EE   E EE+E+
Sbjct: 977 DEEDDEEDEEDED 989



 Score = 33.1 bits (74), Expect = 0.98
 Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 14/83 (16%)

Query: 30  EPEPEPEPEPEPEPESEPEPEPELVEAEAAEA--------SVEEPGEEAATVAATEEGDQ 81
           E E +PE E E      P  +P   + E  +         +++  GEEA+  +++E+ D+
Sbjct: 920 EDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEK-DE 978

Query: 82  EQDPEPEEEAAVEGEEEEEGAAT 104
           E D E EE+     E+ EE   T
Sbjct: 979 EDDEEDEED-----EDREEAVDT 996



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 30/114 (26%), Positives = 39/114 (34%), Gaps = 9/114 (7%)

Query: 30   EPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEE 89
            E  P   P   P P   P P P  VE    E     P     T    +E    +   P E
Sbjct: 1068 EERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSP----VTPLPEQEASPARPAGPTE 1123

Query: 90   EAAVEG--EEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVE 141
            E+         E  A   A AP     P  P  +P LPP P+   + ++   +E
Sbjct: 1124 ESPPSAPLRPPEPPAGPPAPAPRPDERPSSP--IPLLPP-PKKRRKTVSFSAIE 1174



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 25/101 (24%), Positives = 31/101 (30%), Gaps = 38/101 (37%)

Query: 28  GGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEP 87
           GG P P P P  +P P   P P P       A   +  P  + A +           P P
Sbjct: 591 GGSPPPAPTPPQQPPPPPPPPPPP---PPYLASLPLGYPPHQPAYLL---------PPRP 638

Query: 88  EEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLP 128
           +                           PPPP+ PP PP P
Sbjct: 639 D--------------------------GPPPPEYPPPPPPP 653


>gi|45935385 SAM and SH3 domain containing 1 [Homo sapiens]
          Length = 1247

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 22/31 (70%), Positives = 24/31 (77%)

Query: 28 GGEPEPEPEPEPEPEPESEPEPEPELVEAEA 58
          G EPEPEPEPEPEP PE EPEP+P    +EA
Sbjct: 10 GPEPEPEPEPEPEPAPEPEPEPKPGAGTSEA 40



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 23/32 (71%), Positives = 24/32 (75%), Gaps = 1/32 (3%)

Query: 21 EFRGPCGGGEPEPEPEPEPEPEPESEPEPEPE 52
          E  G  G G PEPEPEPEPEPEP  EPEPEP+
Sbjct: 2  EDAGAAGPG-PEPEPEPEPEPEPAPEPEPEPK 32



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/33 (63%), Positives = 22/33 (66%)

Query: 24 GPCGGGEPEPEPEPEPEPEPESEPEPEPELVEA 56
          GP    EPEPEPEPEP PEPE EP+P     EA
Sbjct: 8  GPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEA 40


>gi|215820635 protein phosphatase 1, regulatory subunit 13 like
           [Homo sapiens]
          Length = 828

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 17/132 (12%)

Query: 31  PEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG----DQEQDPE 86
           P+ +P+P+P+P+P+S+P+P+         +     P     T     EG      E +PE
Sbjct: 404 PKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPE 463

Query: 87  PEEEA----AVEGEEEEEGAATAAAAPG--HSAVPPPPPQLPP-------LPPLPRPLSE 133
           PE E      +E  + +EG      +P     A+PP    +P        L  +PRPL  
Sbjct: 464 PEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKR 523

Query: 134 RITREEVEGESL 145
           R + E+    +L
Sbjct: 524 RGSMEQAPAVAL 535



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 43/165 (26%), Positives = 52/165 (31%), Gaps = 59/165 (35%)

Query: 25  PCGGGEPEPEPEPEPEPEPES-------------------------------EPEPEPEL 53
           P   G P+P  E EPEPE E                                E +  PEL
Sbjct: 448 PVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPEL 507

Query: 54  VEAEAAEASVEEP------GEEAATVAA--TEEGDQEQ---------------DPEPEEE 90
            E     A +  P       E+A  VA   T +   +Q                PEPE  
Sbjct: 508 EEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELS 567

Query: 91  AAVEGEEEEEGA-ATAAAAPGHSAVPPPPPQLPPLPPLPRPLSER 134
              EG E   G  A A  AP    +PPP P     P  P+ +  R
Sbjct: 568 PITEGSEARAGPPAPAPPAP----IPPPAPSQSSPPEQPQSMEMR 608


>gi|63003907 protein phosphatase 1, regulatory subunit 13 like [Homo
           sapiens]
          Length = 828

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 17/132 (12%)

Query: 31  PEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEG----DQEQDPE 86
           P+ +P+P+P+P+P+S+P+P+         +     P     T     EG      E +PE
Sbjct: 404 PKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPE 463

Query: 87  PEEEA----AVEGEEEEEGAATAAAAPG--HSAVPPPPPQLPP-------LPPLPRPLSE 133
           PE E      +E  + +EG      +P     A+PP    +P        L  +PRPL  
Sbjct: 464 PEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKR 523

Query: 134 RITREEVEGESL 145
           R + E+    +L
Sbjct: 524 RGSMEQAPAVAL 535



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 43/165 (26%), Positives = 52/165 (31%), Gaps = 59/165 (35%)

Query: 25  PCGGGEPEPEPEPEPEPEPES-------------------------------EPEPEPEL 53
           P   G P+P  E EPEPE E                                E +  PEL
Sbjct: 448 PVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPEL 507

Query: 54  VEAEAAEASVEEP------GEEAATVAA--TEEGDQEQ---------------DPEPEEE 90
            E     A +  P       E+A  VA   T +   +Q                PEPE  
Sbjct: 508 EEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELS 567

Query: 91  AAVEGEEEEEGA-ATAAAAPGHSAVPPPPPQLPPLPPLPRPLSER 134
              EG E   G  A A  AP    +PPP P     P  P+ +  R
Sbjct: 568 PITEGSEARAGPPAPAPPAP----IPPPAPSQSSPPEQPQSMEMR 608


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,641,406
Number of Sequences: 37866
Number of extensions: 1956836
Number of successful extensions: 33886
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 630
Number of HSP's successfully gapped in prelim test: 1035
Number of HSP's that attempted gapping in prelim test: 15941
Number of HSP's gapped (non-prelim): 11740
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.