Guide to the Human Genome
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Search of human proteins with 29788987

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
         (558 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa...  1132   0.0  
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso...  1132   0.0  
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso...  1079   0.0  
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e...   704   0.0  
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex...   395   e-110
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...   215   7e-56
gi|45504369 solute carrier family 24, member 5 [Homo sapiens]         203   4e-52
gi|39995086 solute carrier family 24 member 6 [Homo sapiens]           77   5e-14
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ...    65   1e-10
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),...    65   1e-10
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),...    65   1e-10
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),...    65   1e-10
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ...    63   8e-10
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ...    63   8e-10
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ...    63   8e-10
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ...    63   8e-10
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ...    60   4e-09
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),...    60   4e-09
gi|57163987 solute carrier family 8 member 2 [Homo sapiens]            60   7e-09
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 42   0.001
gi|8923842 forkhead box J2 [Homo sapiens]                              40   0.006
gi|5730045 solute carrier family 16, member 2 [Homo sapiens]           39   0.010
gi|32307177 forkhead box G1 [Homo sapiens]                             39   0.010
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...    39   0.016
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...    39   0.016
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...    39   0.016
gi|169636435 caudal type homeobox 2 [Homo sapiens]                     38   0.021
gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens]       38   0.028
gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens]       38   0.028
gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens]       38   0.028

>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
           sapiens]
          Length = 558

 Score = 1132 bits (2927), Expect = 0.0
 Identities = 558/558 (100%), Positives = 558/558 (100%)

Query: 1   MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60
           MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP
Sbjct: 1   MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60

Query: 61  SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120
           SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI
Sbjct: 61  SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120

Query: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180
           IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI
Sbjct: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180

Query: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240
           MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP
Sbjct: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240

Query: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300
           VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK
Sbjct: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300

Query: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
           PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK
Sbjct: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360

Query: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420
           VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI
Sbjct: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420

Query: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480
           PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV
Sbjct: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480

Query: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540
           VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM
Sbjct: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540

Query: 541 IEFNVFTFVNLPMCREDD 558
           IEFNVFTFVNLPMCREDD
Sbjct: 541 IEFNVFTFVNLPMCREDD 558


>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
           [Homo sapiens]
          Length = 605

 Score = 1132 bits (2927), Expect = 0.0
 Identities = 558/558 (100%), Positives = 558/558 (100%)

Query: 1   MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60
           MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP
Sbjct: 48  MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 107

Query: 61  SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120
           SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI
Sbjct: 108 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 167

Query: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180
           IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI
Sbjct: 168 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 227

Query: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240
           MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP
Sbjct: 228 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 287

Query: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300
           VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK
Sbjct: 288 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 347

Query: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
           PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK
Sbjct: 348 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 407

Query: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420
           VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI
Sbjct: 408 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 467

Query: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480
           PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV
Sbjct: 468 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 527

Query: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540
           VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM
Sbjct: 528 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 587

Query: 541 IEFNVFTFVNLPMCREDD 558
           IEFNVFTFVNLPMCREDD
Sbjct: 588 IEFNVFTFVNLPMCREDD 605


>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
           [Homo sapiens]
          Length = 586

 Score = 1079 bits (2790), Expect = 0.0
 Identities = 539/558 (96%), Positives = 539/558 (96%), Gaps = 19/558 (3%)

Query: 1   MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60
           MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP
Sbjct: 48  MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 107

Query: 61  SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120
           SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI
Sbjct: 108 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 167

Query: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180
           IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI
Sbjct: 168 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 227

Query: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240
           MKYNVKMQAFFTVKQKSIANGNPVNSELEA                   VKEKPQYGKNP
Sbjct: 228 MKYNVKMQAFFTVKQKSIANGNPVNSELEA-------------------VKEKPQYGKNP 268

Query: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300
           VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK
Sbjct: 269 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 328

Query: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
           PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK
Sbjct: 329 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 388

Query: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420
           VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI
Sbjct: 389 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 448

Query: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480
           PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV
Sbjct: 449 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 508

Query: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540
           VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM
Sbjct: 509 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 568

Query: 541 IEFNVFTFVNLPMCREDD 558
           IEFNVFTFVNLPMCREDD
Sbjct: 569 IEFNVFTFVNLPMCREDD 586


>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 3 [Homo sapiens]
          Length = 644

 Score =  704 bits (1817), Expect = 0.0
 Identities = 357/568 (62%), Positives = 432/568 (76%), Gaps = 25/568 (4%)

Query: 6   GTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKI 65
           G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDDFFVPSLEKI
Sbjct: 80  GLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKI 139

Query: 66  CERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCG 125
           CERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFNILCIIGVCG
Sbjct: 140 CERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCG 199

Query: 126 LFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNV 185
           LFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+ YI+IMKYN 
Sbjct: 200 LFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNA 259

Query: 186 KMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVD 245
            +   F  + K    GN VN  L    +  D S  D +V LL   K+   + K  V+MVD
Sbjct: 260 CIHQCFERRTKGA--GNMVNG-LANNAEIDDSSNCDATVVLL---KKANFHRKASVIMVD 313

Query: 246 EIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS---ANGVSSKPL 302
           E++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS    NG S   +
Sbjct: 314 ELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAI 373

Query: 303 QNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPPPEPEPVEAD 346
           +      +ENG  P   P+                +  +N+ +         E E  +  
Sbjct: 374 KIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEG 433

Query: 347 FLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYI 406
             +PF  P  + + VKW FTWPL F+L  T+PNC+KPRWEK+FMVTF ++TLWIA FSY+
Sbjct: 434 PYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYM 493

Query: 407 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDI 466
           MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN+IGSNVFDI
Sbjct: 494 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDI 553

Query: 467 LVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVY 526
           L+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW+LD+KLG  
Sbjct: 554 LIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 613

Query: 527 VLVLYAIFLCFSIMIEFNVFTFVNLPMC 554
            L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 614 CLLLYGVFLCFSIMTEFNVFTFVNLPMC 641


>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 2 [Homo sapiens]
          Length = 661

 Score =  395 bits (1016), Expect = e-110
 Identities = 223/571 (39%), Positives = 338/571 (59%), Gaps = 42/571 (7%)

Query: 3   PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 62
           P++    ++N TD A  ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161

Query: 63  EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 122
             I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221

Query: 123 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 182
           +C LF+ +++ LTWW + RD  +Y + +I+LI+F  D  I+WWE L+L+  Y  Y++ MK
Sbjct: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281

Query: 183 YNVKMQAFFTVKQKSIANGNPV--------NSELEAGNDFYDGSYDDPSVPLLGQVKEKP 234
           +NV+++ +     K + N N V         ++  A  D      D+P++P     K + 
Sbjct: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARD-----KDEPTLP----AKPRL 328

Query: 235 QYGKNPVVMVDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII-- 283
           Q G +   + + +M +S  +           E G   ++   +      R R  + I+  
Sbjct: 329 QRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHK 388

Query: 284 -------INERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 336
                  ++E +R   +AN V    L N    ++E    P  +  +P QN       +  
Sbjct: 389 IAKKKCHVDENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGA 446

Query: 337 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 396
             +    E D     + P     +V ++  +P++F L +T+P+  KP   KFF +TF  +
Sbjct: 447 EAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGS 506

Query: 397 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 456
             WIAVFSY+MVW    +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS
Sbjct: 507 ITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 566

Query: 457 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 516
           +++GSN+FDI VGL +PW L T++  +   V ++S GL  ++VLL   +   +L I L K
Sbjct: 567 SSVGSNIFDITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCK 625

Query: 517 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFT 547
           WR+++ LG  +  LY +FL  S+++E  + T
Sbjct: 626 WRMNKILGFIMFGLYFVFLVVSVLLEDRILT 656


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score =  215 bits (548), Expect = 7e-56
 Identities = 131/348 (37%), Positives = 191/348 (54%), Gaps = 45/348 (12%)

Query: 16  PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLS 72
           P +H   E+P DLFS +ER+ G V+LH+ G +Y+F ALAIVCD++FVP+L  I ++L +S
Sbjct: 432 PDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQIS 491

Query: 73  EDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVV 132
           EDVAGATFMAAG S PELF S+IGVFI+H +VG+GTIVGSAVFNIL +IG C LF+ +++
Sbjct: 492 EDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREIL 551

Query: 133 RLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFT 192
            LTWW + RD  +Y + +I+LI+F  D  I WWE L+L++ Y FY+  MK+N  ++ +  
Sbjct: 552 NLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWV- 610

Query: 193 VKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSP 252
              K   +  PV   +         + +D S P  G             + VDE+  +  
Sbjct: 611 ---KEQLSRRPVAKVM---------ALEDLSKPGDG------------AIAVDELQDNK- 645

Query: 253 PKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIEN 312
            K   P    R       G  +     S I     Q +++S + +    L   + E   N
Sbjct: 646 -KLKLPSLLTR-------GSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLN 697

Query: 313 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
                +    PQ   E +P  +    EP  + A  ++P  VP+ +GD+
Sbjct: 698 QGARAQ----PQAKAESKPEEE----EPAKLPAVTVTPAPVPDIKGDQ 737



 Score =  184 bits (466), Expect = 2e-46
 Identities = 95/244 (38%), Positives = 149/244 (61%), Gaps = 7/244 (2%)

Query: 304  NGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKW 363
            +   E  E      E  E+ Q+ +E++   +      EP+  D+      PE R  +  +
Sbjct: 858  DSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDW------PETRQKQAIY 911

Query: 364  VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDV 423
            +F  P++F L +T+P+  +    KFF+ TF+ + +WIA+FSY+MVW    +G T+GI + 
Sbjct: 912  LFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEE 971

Query: 424  IMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNY 483
            IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS+++GSN+FDI VGL VPW L   ++N 
Sbjct: 972  IMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPW-LLFSLING 1030

Query: 484  GSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEF 543
               V ++S GL  ++VLL   +   +  I   KWR+++ LG  + +LY +FL  S+M+E 
Sbjct: 1031 LQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLED 1090

Query: 544  NVFT 547
             + +
Sbjct: 1091 RIIS 1094



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 34/124 (27%), Positives = 61/124 (49%), Gaps = 7/124 (5%)

Query: 64   KICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGV 123
            ++ E + +SE++ G T +AAG+S P+L  SVI      GD+ V + VGS +F+I   + V
Sbjct: 961  QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1020

Query: 124  CGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIV--WWE-----GLVLIILYVF 176
              L    +  L    V  + ++  I ++ L++      I    W      G  + +LY  
Sbjct: 1021 PWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV 1080

Query: 177  YILI 180
            +++I
Sbjct: 1081 FLII 1084



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 389 FMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 448
           F + ++   L I    Y +  L  +I   L I + + G TF+AAG S P+   SLI    
Sbjct: 460 FGMMYVFVALAIVCDEYFVPAL-GVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFI 518

Query: 449 GLGDMAVSNTIGSNVFDILVGLG 471
              ++ +   +GS VF+IL  +G
Sbjct: 519 SHSNVGIGTIVGSAVFNILFVIG 541


>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
          Length = 500

 Score =  203 bits (516), Expect = 4e-52
 Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)

Query: 343 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 402
           V  D  S F++PEA   ++ WV + P+I LL +T P+C K  W+ +F++TF  + +WI+ 
Sbjct: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347

Query: 403 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 462
           F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407

Query: 463 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 522
           VFD+L  LG+PW ++T  +N  +  ++NSRGL Y  + L  S+    L +H N W+LDRK
Sbjct: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466

Query: 523 LGVYVLVLYAIFLCFSIMIEFNV 545
           LG+  L+ Y      S++ E  +
Sbjct: 467 LGIVCLLSYLGLATLSVLYELGI 489



 Score =  185 bits (470), Expect = 8e-47
 Identities = 103/282 (36%), Positives = 150/282 (53%), Gaps = 42/282 (14%)

Query: 7   TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 66
           T  +  C      EFP   F+ +ER+ G ++++ L  +YMF A++IVCD++F+PSLE I 
Sbjct: 40  TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99

Query: 67  ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 126
           E L LS+DVAG TFMAAGSS PEL  + +GVFIT GD+G+ TI+GSA++N+L I   CGL
Sbjct: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159

Query: 127 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 186
            +  V  L+ W + RD   YTIS   ++  IYD Q+ W+EG +L+++Y  Y+L++ +++K
Sbjct: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219

Query: 187 MQAFFTVKQKSIA--------------------NGNPV---NSELEAGNDFYDGSYDDPS 223
           +  +   K                          G P     S  ++G  + D  Y   S
Sbjct: 220 INQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLS 279

Query: 224 VPL--LGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLR 263
           + L  L QV E P                 P  F  PEA L+
Sbjct: 280 ISLHGLSQVSEDP-----------------PSVFNMPEADLK 304



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)

Query: 388 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 447
           F ++ ++   + I    Y +  L  II  +LG+   + G TF+AAG+S P+ + + +   
Sbjct: 73  FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131

Query: 448 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 507
              GD+ +S  +GS ++++L G+    GL +  V+  S   +      Y++       A 
Sbjct: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184

Query: 508 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 541
            VLGI  +   +  +  L + +  LY + LCF I I
Sbjct: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 67  ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 126
           E L + + V G T +AAG+S P+  ASV+      GD+ +  IVGS VF++LC +G+   
Sbjct: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419

Query: 127 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 158
                +  +  A    R   Y TIS+ + I+F++
Sbjct: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453


>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
          Length = 584

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 49/160 (30%), Positives = 86/160 (53%), Gaps = 4/160 (2%)

Query: 388 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 447
           F  + F+T+ LWI   +  +V ++  +G    + + ++G+T LA G S+ D  +   +AR
Sbjct: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480

Query: 448 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SV 505
           QG   MA S   G  +F+ILVG+G+  G    +    + VK+   G LV+ +   LG S+
Sbjct: 481 QGYPRMAFSACFGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL 538

Query: 506 ALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNV 545
             +++ + L  ++L R  G  +L+ Y  FL  +++ EF V
Sbjct: 539 VFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 3/146 (2%)

Query: 35  AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 94
           AV L++   LY+F  L +    FF P+L  I   L LS +VAG TF+A G+  P++F+++
Sbjct: 99  AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158

Query: 95  IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 153
           +     H   + +G + G+ V     + G  G+              RD V+Y ++V + 
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216

Query: 154 IVFIYDEQIVWWEGLVLIILYVFYIL 179
            + ++  ++     L  + LYVFY++
Sbjct: 217 FLMLFRGRVTLAWALGYLGLYVFYVV 242



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)

Query: 394 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 442
           +  TL+++   Y+ + L           ++ I  TL +   + G+TFLA G   PD  ++
Sbjct: 98  LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157

Query: 443 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 498
           L+         +  +T G      L G GV   L T VV  G T+       SR     +
Sbjct: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206

Query: 499 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 536
           V  + +V LT L +   +    W L   LG+YV  +  + LC
Sbjct: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247


>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform A [Homo sapiens]
          Length = 973

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 804 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 863

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 864 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 913



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 38  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 79
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138

Query: 80  FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 134
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198

Query: 135 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 174
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 831 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 890

Query: 130 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 157
                    + V   ++ +++++  +  FI
Sbjct: 891 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 920


>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform D [Homo sapiens]
          Length = 937

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 38  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 79
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138

Query: 80  FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 134
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198

Query: 135 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 174
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854

Query: 130 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 157
                    + V   ++ +++++  +  FI
Sbjct: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884


>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform C [Homo sapiens]
          Length = 960

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 791 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 850

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 851 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 900



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 38  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 79
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138

Query: 80  FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 134
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198

Query: 135 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 174
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 818 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 877

Query: 130 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 157
                    + V   ++ +++++  +  FI
Sbjct: 878 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 907


>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform B [Homo sapiens]
          Length = 968

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
           FI + L I + +  +  L +  G T+G+ D +  + F+A GTSVPD  AS + A Q    
Sbjct: 799 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 858

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
           D ++ N  GSN  ++ +G+GV W +  +     G   K++   L +SV L
Sbjct: 859 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 908



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)

Query: 38  LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 79
           ++ +  +YMF  ++I+ D F + S+E I  +                     +E V+  T
Sbjct: 80  VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138

Query: 80  FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 134
            MA GSS PE+  SVI V     T GD+G  TIVGSA FN+  II +C      G+  ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198

Query: 135 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 174
                ++     S++    + +++  I    +  WEGL+    +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS V      + D  +G + GS   N+   IGV    A 
Sbjct: 826 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 885

Query: 130 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 157
                    + V   ++ +++++  +  FI
Sbjct: 886 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 915


>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform B precursor [Homo sapiens]
          Length = 924

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)

Query: 36  VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 77
           V+++ +  +YMF  ++I+ D F   S+E I  +                     +E V+ 
Sbjct: 77  VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135

Query: 78  ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 131
            T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+ 
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194

Query: 132 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 179
            ++     ++     S++  I + +++       +  WEGL+ +  +   +L        
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254

Query: 180 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 232
           ++ Y    + + T K + I       +P   E++     + F DG+     VPL G  KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308

Query: 233 KPQYGKNPVVMVDEIMSSSPPK 254
             +  +  + ++ ++    P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 755 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 814

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 815 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 874

Query: 509 VL 510
           VL
Sbjct: 875 VL 876



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 782 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 837

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 838 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 871



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184


>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform D precursor [Homo sapiens]
          Length = 921

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)

Query: 36  VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 77
           V+++ +  +YMF  ++I+ D F   S+E I  +                     +E V+ 
Sbjct: 77  VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135

Query: 78  ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 131
            T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+ 
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194

Query: 132 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 179
            ++     ++     S++  I + +++       +  WEGL+ +  +   +L        
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254

Query: 180 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 232
           ++ Y    + + T K + I       +P   E++     + F DG+     VPL G  KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308

Query: 233 KPQYGKNPVVMVDEIMSSSPPK 254
             +  +  + ++ ++    P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871

Query: 509 VL 510
           VL
Sbjct: 872 VL 873



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184


>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform A precursor [Homo sapiens]
          Length = 925

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)

Query: 36  VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 77
           V+++ +  +YMF  ++I+ D F   S+E I  +                     +E V+ 
Sbjct: 77  VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135

Query: 78  ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 131
            T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+ 
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194

Query: 132 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 179
            ++     ++     S++  I + +++       +  WEGL+ +  +   +L        
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254

Query: 180 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 232
           ++ Y    + + T K + I       +P   E++     + F DG+     VPL G  KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308

Query: 233 KPQYGKNPVVMVDEIMSSSPPK 254
             +  +  + ++ ++    P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875

Query: 509 VL 510
           VL
Sbjct: 876 VL 877



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184


>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform C precursor [Homo sapiens]
          Length = 927

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)

Query: 36  VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 77
           V+++ +  +YMF  ++I+ D F   S+E I  +                     +E V+ 
Sbjct: 77  VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135

Query: 78  ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 131
            T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+ 
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194

Query: 132 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 179
            ++     ++     S++  I + +++       +  WEGL+ +  +   +L        
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254

Query: 180 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 232
           ++ Y    + + T K + I       +P   E++     + F DG+     VPL G  KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308

Query: 233 KPQYGKNPVVMVDEIMSSSPPK 254
             +  +  + ++ ++    P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877

Query: 509 VL 510
           VL
Sbjct: 878 VL 879



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184


>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform F [Homo sapiens]
          Length = 284

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 115 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 174

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 175 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 234

Query: 509 VL 510
           VL
Sbjct: 235 VL 236



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 142 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 197

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 198 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 231


>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform G [Homo sapiens]
          Length = 298

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 129 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 188

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 189 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 248

Query: 509 VL 510
           VL
Sbjct: 249 VL 250



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 156 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 211

Query: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
            V  + W      + V   ++ +++++  +  F+
Sbjct: 212 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 245


>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
          Length = 921

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)

Query: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
           F  + L I + + ++  L +  G T+G+ D +  + F+A GTS+PD  AS + A Q    
Sbjct: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811

Query: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
           D ++ N  GSN  ++ +GLGV W +  +     G   ++ +  L +SV L
Sbjct: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)

Query: 37  LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 78
           +++ +  +YMF  ++I+ D F   ++E I  +                     +E V+  
Sbjct: 73  VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131

Query: 79  TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 133
           T MA GSS PE+  SVI V       G++G GTIVGSA FN+  +I VC   + AG+  +
Sbjct: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191

Query: 134 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 174
           +    V   +  ++I   V   LI+ ++   +V  WE L+ ++ +
Sbjct: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)

Query: 71  LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 129
           L + V    F+A G+S P+ FAS +        D  +G + GS   N+   +GV    A 
Sbjct: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838

Query: 130 QVVRLTWWAV 139
                 +WAV
Sbjct: 839 -----VYWAV 843


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/67 (34%), Positives = 30/67 (44%), Gaps = 9/67 (13%)

Query: 311 ENGNVPVENPEDPQQNQEQQPPPQPPP---------PEPEPVEADFLSPFSVPEARGDKV 361
           ++G  P E+PE P       PPP PPP         PEP P     L+P   PEA  +  
Sbjct: 15  QDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESA 74

Query: 362 KWVFTWP 368
             ++T P
Sbjct: 75  TELYTEP 81



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 4/47 (8%)

Query: 313 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFL----SPFSVPE 355
           G  P ++ E P ++ E  PP  PPPP P P  A  L    SP  +PE
Sbjct: 10  GTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPE 56



 Score = 29.3 bits (64), Expect = 10.0
 Identities = 10/33 (30%), Positives = 16/33 (48%)

Query: 310 IENGNVPVENPEDPQQNQEQQPPPQPPPPEPEP 342
           ++ G    +    PQ  ++    P+PPPP P P
Sbjct: 1   MDRGAAAAQGTAPPQDGEQPAESPEPPPPWPPP 33


>gi|8923842 forkhead box J2 [Homo sapiens]
          Length = 574

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 2/41 (4%)

Query: 318 ENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARG 358
           + P  PQQ Q+QQ PPQPPP + +P +    +P   P A G
Sbjct: 293 QQPPPPQQQQQQQQPPQPPPQQSQPQQQQ--APAQGPSAVG 331


>gi|5730045 solute carrier family 16, member 2 [Homo sapiens]
          Length = 613

 Score = 39.3 bits (90), Expect = 0.010
 Identities = 33/110 (30%), Positives = 47/110 (42%), Gaps = 14/110 (12%)

Query: 249 SSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHE 308
           SSSPP  +   +       NK+ P++     S         L + A+  +  P Q    E
Sbjct: 42  SSSPPSSSSCSS------RNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQE 95

Query: 309 NIENGNVPVENPEDPQQNQEQQPPPQP---PPPEPEPVEADFLSPFSVPE 355
             E    PV +PE P+   E +P P+P   PPPEP+P       P  +PE
Sbjct: 96  QQE----PVGSPE-PESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPE 140


>gi|32307177 forkhead box G1 [Homo sapiens]
          Length = 489

 Score = 39.3 bits (90), Expect = 0.010
 Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)

Query: 303 QNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEP 342
           Q+  H +  + + P   P+ P   Q+QQPPP PPPP P+P
Sbjct: 46  QHHHHHHHHHHHPPPPAPQPPPPPQQQQPPP-PPPPAPQP 84


>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 316  PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 353
            P   P  PQQ  +QQP PQP  PPP P P +   LS  S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)

Query: 321  EDPQQNQEQQPPPQPP----PPEPEPVEA 345
            E P  NQ+QQPPP PP    PP P+P  A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)

Query: 276  LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 334
            L  +S ++  +   + +S + +    +Q   + +I++  +  VE P   QQ Q   PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657

Query: 335  P---PPPEPEP 342
                PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)

Query: 320  PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 354
            P  PQQ Q    + QP PQPPPP+ +P +     P   P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)

Query: 318  ENPEDPQQNQEQQPPPQP-PPPEPEP 342
            + P  P   Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 316  PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 353
            P   P  PQQ  +QQP PQP  PPP P P +   LS  S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)

Query: 321  EDPQQNQEQQPPPQPP----PPEPEPVEA 345
            E P  NQ+QQPPP PP    PP P+P  A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)

Query: 276  LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 334
            L  +S ++  +   + +S + +    +Q   + +I++  +  VE P   QQ Q   PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657

Query: 335  P---PPPEPEP 342
                PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)

Query: 320  PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 354
            P  PQQ Q    + QP PQPPPP+ +P +     P   P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)

Query: 318  ENPEDPQQNQEQQPPPQP-PPPEPEP 342
            + P  P   Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 316  PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 353
            P   P  PQQ  +QQP PQP  PPP P P +   LS  S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)

Query: 321  EDPQQNQEQQPPPQPP----PPEPEPVEA 345
            E P  NQ+QQPPP PP    PP P+P  A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)

Query: 276  LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 334
            L  +S ++  +   + +S + +    +Q   + +I++  +  VE P   QQ Q   PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657

Query: 335  P---PPPEPEP 342
                PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)

Query: 320  PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 354
            P  PQQ Q    + QP PQPPPP+ +P +     P   P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)

Query: 318  ENPEDPQQNQEQQPPPQP-PPPEPEP 342
            + P  P   Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674


>gi|169636435 caudal type homeobox 2 [Homo sapiens]
          Length = 313

 Score = 38.1 bits (87), Expect = 0.021
 Identities = 17/31 (54%), Positives = 20/31 (64%)

Query: 325 QNQEQQPPPQPPPPEPEPVEADFLSPFSVPE 355
           Q Q+QQ PPQPPPP P+P +       SVPE
Sbjct: 250 QQQQQQQPPQPPPPPPQPPQPQPGPLRSVPE 280



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 280 SRIIINERQRLINSANGVSSKPL----QNGRHENIENGNVPVENPEDPQQNQEQQPPPQP 335
           SR I   R+  + +  G+S + +    QN R +  +     ++  +  Q  Q   PPPQP
Sbjct: 208 SRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQP 267

Query: 336 PPPEPEPVEA--DFLSPFSVPEA 356
           P P+P P+ +  + LSP S  +A
Sbjct: 268 PQPQPGPLRSVPEPLSPVSSLQA 290


>gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens]
          Length = 429

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)

Query: 275 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 334
           +L   S + IN  Q +      + S+P+   R     +G       +  QQ Q+QQ PP 
Sbjct: 307 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 355

Query: 335 PPPPEPEP 342
           PP P+P+P
Sbjct: 356 PPQPQPQP 363


>gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens]
          Length = 437

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)

Query: 275 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 334
           +L   S + IN  Q +      + S+P+   R     +G       +  QQ Q+QQ PP 
Sbjct: 315 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 363

Query: 335 PPPPEPEP 342
           PP P+P+P
Sbjct: 364 PPQPQPQP 371


>gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens]
          Length = 497

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)

Query: 275 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 334
           +L   S + IN  Q +      + S+P+   R     +G       +  QQ Q+QQ PP 
Sbjct: 375 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 423

Query: 335 PPPPEPEP 342
           PP P+P+P
Sbjct: 424 PPQPQPQP 431


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,299,116
Number of Sequences: 37866
Number of extensions: 1131182
Number of successful extensions: 17758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 13163
Number of HSP's gapped (non-prelim): 3111
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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