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Search of human proteins with 29788985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29788985 solute carrier family 24 member 4 isoform 2
precursor [Homo sapiens]
(586 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 1186 0.0
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 1174 0.0
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 1079 0.0
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 700 0.0
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 390 e-108
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 222 6e-58
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 203 4e-52
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 119 6e-27
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 65 1e-10
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 62 1e-09
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 62 1e-09
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 62 1e-09
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 62 1e-09
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 60 4e-09
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 60 4e-09
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 60 7e-09
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 42 0.001
gi|8923842 forkhead box J2 [Homo sapiens] 40 0.006
gi|5730045 solute carrier family 16, member 2 [Homo sapiens] 39 0.010
gi|32307177 forkhead box G1 [Homo sapiens] 39 0.010
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 39 0.017
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 39 0.017
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 39 0.017
gi|169636435 caudal type homeobox 2 [Homo sapiens] 38 0.023
gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens] 38 0.030
gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens] 38 0.030
gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens] 38 0.030
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 1186 bits (3067), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC
Sbjct: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
Query: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE
Sbjct: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
Query: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR
Sbjct: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
Query: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV
Sbjct: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
Query: 241 KQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGP 300
KQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGP
Sbjct: 241 KQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGP 300
Query: 301 RTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPP 360
RTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPP
Sbjct: 301 RTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPP 360
Query: 361 PQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVT 420
PQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVT
Sbjct: 361 PQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVT 420
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGD 480
FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGD
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGD 480
Query: 481 MAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGI 540
MAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGI
Sbjct: 481 MAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGI 540
Query: 541 HLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 586
HLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
Sbjct: 541 HLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 586
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 1174 bits (3037), Expect = 0.0
Identities = 586/605 (96%), Positives = 586/605 (96%), Gaps = 19/605 (3%)
Query: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC
Sbjct: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
Query: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE
Sbjct: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
Query: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR
Sbjct: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
Query: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV
Sbjct: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
Query: 241 KQKSIANGNPVNSELEA-------------------VKEKPQYGKNPVVMVDEIMSSSPP 281
KQKSIANGNPVNSELEA VKEKPQYGKNPVVMVDEIMSSSPP
Sbjct: 241 KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP 300
Query: 282 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 341
KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG
Sbjct: 301 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 360
Query: 342 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 401
NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL
Sbjct: 361 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 420
Query: 402 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 461
CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG
Sbjct: 421 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 480
Query: 462 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 521
TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG
Sbjct: 481 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 540
Query: 522 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 581
LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM
Sbjct: 541 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 600
Query: 582 CREDD 586
CREDD
Sbjct: 601 CREDD 605
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 1079 bits (2790), Expect = 0.0
Identities = 539/558 (96%), Positives = 539/558 (96%), Gaps = 19/558 (3%)
Query: 48 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 107
MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP
Sbjct: 1 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60
Query: 108 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 167
SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI
Sbjct: 61 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120
Query: 168 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 227
IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI
Sbjct: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180
Query: 228 MKYNVKMQAFFTVKQKSIANGNPVNSELEA-------------------VKEKPQYGKNP 268
MKYNVKMQAFFTVKQKSIANGNPVNSELEA VKEKPQYGKNP
Sbjct: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240
Query: 269 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 328
VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK
Sbjct: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300
Query: 329 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 388
PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK
Sbjct: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
Query: 389 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 448
VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI
Sbjct: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420
Query: 449 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 508
PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV
Sbjct: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480
Query: 509 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 568
VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM
Sbjct: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540
Query: 569 IEFNVFTFVNLPMCREDD 586
IEFNVFTFVNLPMCREDD
Sbjct: 541 IEFNVFTFVNLPMCREDD 558
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 700 bits (1807), Expect = 0.0
Identities = 352/571 (61%), Positives = 432/571 (75%), Gaps = 32/571 (5%)
Query: 44 NRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDD 103
N L + G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDD
Sbjct: 71 NDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDD 130
Query: 104 FFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 163
FFVPSLEKICERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFN
Sbjct: 131 FFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 190
Query: 164 ILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVF 223
ILCIIGVCGLFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+
Sbjct: 191 ILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLI 250
Query: 224 YILIMKYNVKMQAFFTVKQK---SIANGNPVNSELE----------AVKEKPQYGKNPVV 270
YI+IMKYN + F + K ++ NG N+E++ +K+ + K V+
Sbjct: 251 YIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVI 310
Query: 271 MVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS---ANGVSS 327
MVDE++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS NG S
Sbjct: 311 MVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESE 370
Query: 328 KPLQNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPPPEPEPV 371
++ +ENG P P+ + +N+ + E E
Sbjct: 371 VAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDD 430
Query: 372 EADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVF 431
+ +PF P + + VKW FTWPL F+L T+PNC+KPRWEK+FMVTF ++TLWIA F
Sbjct: 431 DEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAF 490
Query: 432 SYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNV 491
SY+MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN+IGSNV
Sbjct: 491 SYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNV 550
Query: 492 FDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKL 551
FDIL+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW+LD+KL
Sbjct: 551 FDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKL 610
Query: 552 GVYVLVLYAIFLCFSIMIEFNVFTFVNLPMC 582
G L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 611 GCGCLLLYGVFLCFSIMTEFNVFTFVNLPMC 641
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 390 bits (1003), Expect = e-108
Identities = 219/562 (38%), Positives = 332/562 (59%), Gaps = 43/562 (7%)
Query: 50 PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 109
P++ ++N TD A ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161
Query: 110 EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 169
I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221
Query: 170 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 229
+C LF+ +++ LTWW + RD +Y + +I+LI+F D I+WWE L+L+ Y Y++ MK
Sbjct: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281
Query: 230 YNVKMQAFFTVKQKSIANGNPV--------NSELEAVKEKP----------QYGKNPVVM 271
+NV+++ + K + N N V ++ A ++K Q G + +
Sbjct: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASL 337
Query: 272 VDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII---------IN 313
+ +M +S + E G ++ + R R + I+ ++
Sbjct: 338 HNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVD 397
Query: 314 ERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEA 373
E +R +AN V L N ++E P + +P QN + + E
Sbjct: 398 ENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGAEAQTADEEE 455
Query: 374 DFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSY 433
D + P +V ++ +P++F L +T+P+ KP KFF +TF + WIAVFSY
Sbjct: 456 DQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSY 515
Query: 434 IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFD 493
+MVW +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS+++GSN+FD
Sbjct: 516 LMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFD 575
Query: 494 ILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGV 553
I VGL +PW L T++ + V ++S GL ++VLL + +L I L KWR+++ LG
Sbjct: 576 ITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGF 634
Query: 554 YVLVLYAIFLCFSIMIEFNVFT 575
+ LY +FL S+++E + T
Sbjct: 635 IMFGLYFVFLVVSVLLEDRILT 656
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 222 bits (566), Expect = 6e-58
Identities = 129/329 (39%), Positives = 194/329 (58%), Gaps = 26/329 (7%)
Query: 63 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLS 119
P +H E+P DLFS +ER+ G V+LH+ G +Y+F ALAIVCD++FVP+L I ++L +S
Sbjct: 432 PDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQIS 491
Query: 120 EDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVV 179
EDVAGATFMAAG S PELF S+IGVFI+H +VG+GTIVGSAVFNIL +IG C LF+ +++
Sbjct: 492 EDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREIL 551
Query: 180 RLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFT 239
LTWW + RD +Y + +I+LI+F D I WWE L+L++ Y FY+ MK+N ++ +
Sbjct: 552 NLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWV- 610
Query: 240 VKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFG 299
K + PV +++ A+++ + G + + VDE+ + K P R G
Sbjct: 611 ---KEQLSRRPV-AKVMALEDLSKPG-DGAIAVDELQDNK--KLKLPSLLTR-------G 656
Query: 300 PRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQP 359
+ S I Q +++S + + L + E N + PQ E +P
Sbjct: 657 SSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQ----PQAKAESKP 712
Query: 360 PPQPPPPEPEPVEADFLSPFSVPEARGDK 388
+ EP + A ++P VP+ +GD+
Sbjct: 713 EEE----EPAKLPAVTVTPAPVPDIKGDQ 737
Score = 184 bits (466), Expect = 3e-46
Identities = 95/244 (38%), Positives = 149/244 (61%), Gaps = 7/244 (2%)
Query: 332 NGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKW 391
+ E E E E+ Q+ +E++ + EP+ D+ PE R + +
Sbjct: 858 DSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDW------PETRQKQAIY 911
Query: 392 VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDV 451
+F P++F L +T+P+ + KFF+ TF+ + +WIA+FSY+MVW +G T+GI +
Sbjct: 912 LFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEE 971
Query: 452 IMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNY 511
IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS+++GSN+FDI VGL VPW L ++N
Sbjct: 972 IMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPW-LLFSLING 1030
Query: 512 GSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEF 571
V ++S GL ++VLL + + I KWR+++ LG + +LY +FL S+M+E
Sbjct: 1031 LQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLED 1090
Query: 572 NVFT 575
+ +
Sbjct: 1091 RIIS 1094
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/124 (27%), Positives = 61/124 (49%), Gaps = 7/124 (5%)
Query: 111 KICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGV 170
++ E + +SE++ G T +AAG+S P+L SVI GD+ V + VGS +F+I + V
Sbjct: 961 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1020
Query: 171 CGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIV--WWE-----GLVLIILYVF 223
L + L V + ++ I ++ L++ I W G + +LY
Sbjct: 1021 PWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV 1080
Query: 224 YILI 227
+++I
Sbjct: 1081 FLII 1084
Score = 38.5 bits (88), Expect = 0.017
Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 417 FMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 476
F + ++ L I Y + L +I L I + + G TF+AAG S P+ SLI
Sbjct: 460 FGMMYVFVALAIVCDEYFVPAL-GVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFI 518
Query: 477 GLGDMAVSNTIGSNVFDILVGLG 499
++ + +GS VF+IL +G
Sbjct: 519 SHSNVGIGTIVGSAVFNILFVIG 541
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 203 bits (516), Expect = 4e-52
Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Query: 371 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 430
V D S F++PEA ++ WV + P+I LL +T P+C K W+ +F++TF + +WI+
Sbjct: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347
Query: 431 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 490
F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407
Query: 491 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 550
VFD+L LG+PW ++T +N + ++NSRGL Y + L S+ L +H N W+LDRK
Sbjct: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466
Query: 551 LGVYVLVLYAIFLCFSIMIEFNV 573
LG+ L+ Y S++ E +
Sbjct: 467 LGIVCLLSYLGLATLSVLYELGI 489
Score = 184 bits (467), Expect = 2e-46
Identities = 84/188 (44%), Positives = 126/188 (67%)
Query: 54 TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 113
T + C EFP F+ +ER+ G ++++ L +YMF A++IVCD++F+PSLE I
Sbjct: 40 TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99
Query: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
E L LS+DVAG TFMAAGSS PEL + +GVFIT GD+G+ TI+GSA++N+L I CGL
Sbjct: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159
Query: 174 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 233
+ V L+ W + RD YTIS ++ IYD Q+ W+EG +L+++Y Y+L++ +++K
Sbjct: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219
Query: 234 MQAFFTVK 241
+ + K
Sbjct: 220 INQYIIKK 227
Score = 50.1 bits (118), Expect = 6e-06
Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 416 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 475
F ++ ++ + I Y + L II +LG+ + G TF+AAG+S P+ + + +
Sbjct: 73 FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131
Query: 476 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 535
GD+ +S +GS ++++L G+ GL + V+ S + Y++ A
Sbjct: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184
Query: 536 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 569
VLGI + + + L + + LY + LCF I I
Sbjct: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220
Score = 49.3 bits (116), Expect = 1e-05
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
E L + + V G T +AAG+S P+ ASV+ GD+ + IVGS VF++LC +G+
Sbjct: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
Query: 174 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 205
+ + A R Y TIS+ + I+F++
Sbjct: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 119 bits (299), Expect = 6e-27
Identities = 125/503 (24%), Positives = 220/503 (43%), Gaps = 34/503 (6%)
Query: 82 AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 141
AV L++ LY+F L + FF P+L I L LS +VAG TF+A G+ P++F+++
Sbjct: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
Query: 142 IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 200
+ H + +G + G+ V + G G+ RD V+Y ++V +
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
Query: 201 IVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQK--SIANGNPVNSELEAV 258
+ ++ ++ L + LYVFY++ V + + +Q+ S+ PV E+ +
Sbjct: 217 FLMLFRGRVTLAWALGYLGLYVFYVV----TVILCTWIYQRQRRGSLFCPMPVTPEILSD 272
Query: 259 KEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRL 318
E+ + N + P F + E +I++ P ++ R+
Sbjct: 273 SEEDRVSSNTNSY--DYGDEYRPLFFYQETTAQILV-RALNPLDYMKW-------RRKSA 322
Query: 319 INSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLS- 377
A V P+ E + VPV +P+ QN ++ P V S
Sbjct: 323 YWKALKVFKLPV-----EFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSG 377
Query: 378 PFSVPEARGDKVKWVFT----WPLIFLLCVTIPNCSKPRWEKFF-MVTFITATLWIAVFS 432
+ V E G WV L + + PR F + F+T+ LWI +
Sbjct: 378 TYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAA 437
Query: 433 YIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVF 492
+V ++ +G + + ++G+T LA G S+ D + +ARQG MA S G +F
Sbjct: 438 TEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIF 497
Query: 493 DILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SVALTVLGIHLNKWRLDRK 550
+ILVG+G+ G + + VK+ G LV+ + LG S+ +++ + L ++L R
Sbjct: 498 NILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRV 555
Query: 551 LGVYVLVLYAIFLCFSIMIEFNV 573
G +L+ Y FL +++ EF V
Sbjct: 556 YGFCLLLFYLNFLVVALLTEFGV 578
Score = 37.7 bits (86), Expect = 0.030
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)
Query: 422 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 470
+ TL+++ Y+ + L ++ I TL + + G+TFLA G PD ++
Sbjct: 98 LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157
Query: 471 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 526
L+ + +T G L G GV L T VV G T+ SR +
Sbjct: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206
Query: 527 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 564
V + +V LT L + + W L LG+YV + + LC
Sbjct: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 804 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 863
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 864 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 913
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 29/226 (12%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAF 237
++ S++ + +++ I + WEGL+ + ++ + F
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLF 258
Query: 238 FTVKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKF 283
+ K G +E ++P K + M ++++S F
Sbjct: 259 YKYVYKRYRAGKQRGMIIEHEGDRPS-SKTEIEMDGKVVNSHVENF 303
Score = 36.6 bits (83), Expect = 0.066
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 831 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 890
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 891 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 920
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 29/226 (12%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAF 237
++ S++ + +++ I + WEGL+ + ++ + F
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLF 258
Query: 238 FTVKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKF 283
+ K G +E ++P K + M ++++S F
Sbjct: 259 YKYVYKRYRAGKQRGMIIEHEGDRPS-SKTEIEMDGKVVNSHVENF 303
Score = 36.6 bits (83), Expect = 0.066
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 791 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 850
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 851 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 900
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 29/226 (12%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAF 237
++ S++ + +++ I + WEGL+ + ++ + F
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLF 258
Query: 238 FTVKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKF 283
+ K G +E ++P K + M ++++S F
Sbjct: 259 YKYVYKRYRAGKQRGMIIEHEGDRPS-SKTEIEMDGKVVNSHVENF 303
Score = 36.6 bits (83), Expect = 0.066
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 818 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 877
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 878 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 907
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 799 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 858
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 859 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 908
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 29/226 (12%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAF 237
++ S++ + +++ I + WEGL+ + ++ + F
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLF 258
Query: 238 FTVKQKSIANGNPVNSELEAVKEKPQYGKNPVVMVDEIMSSSPPKF 283
+ K G +E ++P K + M ++++S F
Sbjct: 259 YKYVYKRYRAGKQRGMIIEHEGDRPS-SKTEIEMDGKVVNSHVENF 303
Score = 36.6 bits (83), Expect = 0.066
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 826 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 885
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 886 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 915
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 30/189 (15%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKM 234
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 235 QAFFTVKQK 243
F+ K
Sbjct: 255 LLFYKYMHK 263
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 755 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 814
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 815 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 874
Query: 537 VL 538
VL
Sbjct: 875 VL 876
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 782 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 837
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 838 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 871
Score = 33.5 bits (75), Expect = 0.56
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 30/189 (15%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKM 234
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 235 QAFFTVKQK 243
F+ K
Sbjct: 255 LLFYKYMHK 263
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871
Query: 537 VL 538
VL
Sbjct: 872 VL 873
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868
Score = 33.5 bits (75), Expect = 0.56
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 30/189 (15%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKM 234
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 235 QAFFTVKQK 243
F+ K
Sbjct: 255 LLFYKYMHK 263
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875
Query: 537 VL 538
VL
Sbjct: 876 VL 877
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872
Score = 33.5 bits (75), Expect = 0.56
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 30/189 (15%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKM 234
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 235 QAFFTVKQK 243
F+ K
Sbjct: 255 LLFYKYMHK 263
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877
Query: 537 VL 538
VL
Sbjct: 878 VL 879
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874
Score = 33.5 bits (75), Expect = 0.56
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 115 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 174
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 175 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 234
Query: 537 VL 538
VL
Sbjct: 235 VL 236
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 142 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 197
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 198 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 231
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 129 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 188
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 189 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 248
Query: 537 VL 538
VL
Sbjct: 249 VL 250
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 156 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 211
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 212 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 245
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 59.7 bits (143), Expect = 7e-09
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
F + L I + + ++ L + G T+G+ D + + F+A GTS+PD AS + A Q
Sbjct: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
Query: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
D ++ N GSN ++ +GLGV W + + G ++ + L +SV L
Sbjct: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)
Query: 84 LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 125
+++ + +YMF ++I+ D F ++E I + +E V+
Sbjct: 73 VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
Query: 126 TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 180
T MA GSS PE+ SVI V G++G GTIVGSA FN+ +I VC + AG+ +
Sbjct: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191
Query: 181 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 221
+ V + ++I V LI+ ++ +V WE L+ ++ +
Sbjct: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236
Score = 35.4 bits (80), Expect = 0.15
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 118 LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + D +G + GS N+ +GV A
Sbjct: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838
Query: 177 QVVRLTWWAV 186
+WAV
Sbjct: 839 -----VYWAV 843
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/67 (34%), Positives = 30/67 (44%), Gaps = 9/67 (13%)
Query: 339 ENGNVPVENPEDPQQNQEQQPPPQPPP---------PEPEPVEADFLSPFSVPEARGDKV 389
++G P E+PE P PPP PPP PEP P L+P PEA +
Sbjct: 15 QDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESA 74
Query: 390 KWVFTWP 396
++T P
Sbjct: 75 TELYTEP 81
Score = 37.0 bits (84), Expect = 0.050
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 341 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFL----SPFSVPE 383
G P ++ E P ++ E PP PPPP P P A L SP +PE
Sbjct: 10 GTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPE 56
>gi|8923842 forkhead box J2 [Homo sapiens]
Length = 574
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 346 ENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARG 386
+ P PQQ Q+QQ PPQPPP + +P + +P P A G
Sbjct: 293 QQPPPPQQQQQQQQPPQPPPQQSQPQQQQ--APAQGPSAVG 331
>gi|5730045 solute carrier family 16, member 2 [Homo sapiens]
Length = 613
Score = 39.3 bits (90), Expect = 0.010
Identities = 33/110 (30%), Positives = 47/110 (42%), Gaps = 14/110 (12%)
Query: 277 SSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHE 336
SSSPP + + NK+ P++ S L + A+ + P Q E
Sbjct: 42 SSSPPSSSSCSS------RNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQE 95
Query: 337 NIENGNVPVENPEDPQQNQEQQPPPQP---PPPEPEPVEADFLSPFSVPE 383
E PV +PE P+ E +P P+P PPPEP+P P +PE
Sbjct: 96 QQE----PVGSPE-PESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPE 140
>gi|32307177 forkhead box G1 [Homo sapiens]
Length = 489
Score = 39.3 bits (90), Expect = 0.010
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 331 QNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEP 370
Q+ H + + + P P+ P Q+QQPPP PPPP P+P
Sbjct: 46 QHHHHHHHHHHHPPPPAPQPPPPPQQQQPPP-PPPPAPQP 84
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.017
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 344 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 381
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.11
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 349 EDPQQNQEQQPPPQPP----PPEPEPVEA 373
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.43
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 304 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 362
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 363 P---PPPEPEP 370
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.95
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 348 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 382
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.8
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 346 ENPEDPQQNQEQQPPPQP-PPPEPEP 370
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.017
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 344 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 381
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.11
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 349 EDPQQNQEQQPPPQPP----PPEPEPVEA 373
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.43
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 304 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 362
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 363 P---PPPEPEP 370
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.95
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 348 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 382
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.8
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 346 ENPEDPQQNQEQQPPPQP-PPPEPEP 370
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.017
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 344 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 381
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.11
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 349 EDPQQNQEQQPPPQPP----PPEPEPVEA 373
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.43
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 304 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 362
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 363 P---PPPEPEP 370
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.95
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 348 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 382
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.8
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 346 ENPEDPQQNQEQQPPPQP-PPPEPEP 370
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|169636435 caudal type homeobox 2 [Homo sapiens]
Length = 313
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/31 (54%), Positives = 20/31 (64%)
Query: 353 QNQEQQPPPQPPPPEPEPVEADFLSPFSVPE 383
Q Q+QQ PPQPPPP P+P + SVPE
Sbjct: 250 QQQQQQQPPQPPPPPPQPPQPQPGPLRSVPE 280
Score = 37.0 bits (84), Expect = 0.050
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 6/83 (7%)
Query: 308 SRIIINERQRLINSANGVSSKPL----QNGRHENIENGNVPVENPEDPQQNQEQQPPPQP 363
SR I R+ + + G+S + + QN R + + ++ + Q Q PPPQP
Sbjct: 208 SRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQP 267
Query: 364 PPPEPEPVEA--DFLSPFSVPEA 384
P P+P P+ + + LSP S +A
Sbjct: 268 PQPQPGPLRSVPEPLSPVSSLQA 290
>gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens]
Length = 429
Score = 37.7 bits (86), Expect = 0.030
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 303 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 362
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 307 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 355
Query: 363 PPPPEPEP 370
PP P+P+P
Sbjct: 356 PPQPQPQP 363
>gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens]
Length = 437
Score = 37.7 bits (86), Expect = 0.030
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 303 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 362
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 315 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 363
Query: 363 PPPPEPEP 370
PP P+P+P
Sbjct: 364 PPQPQPQP 371
>gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens]
Length = 497
Score = 37.7 bits (86), Expect = 0.030
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 303 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 362
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 375 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 423
Query: 363 PPPPEPEP 370
PP P+P+P
Sbjct: 424 PPQPQPQP 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,005,266
Number of Sequences: 37866
Number of extensions: 1146098
Number of successful extensions: 17881
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 13814
Number of HSP's gapped (non-prelim): 2720
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.