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Search of human proteins with 122937271
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937271 WAS protein homolog associated with actin, golgi
membranes and microtubules [Homo sapiens]
(809 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937271 WAS protein homolog associated with actin, golgi me... 1635 0.0
gi|195947369 junction-mediating and regulatory protein [Homo sap... 456 e-128
gi|239745123 PREDICTED: hypothetical protein XP_002343373 [Homo ... 302 9e-82
gi|239745158 PREDICTED: hypothetical protein XP_002343376 [Homo ... 251 1e-66
gi|169208040 PREDICTED: similar to WAS protein homolog associate... 239 1e-62
gi|169208753 PREDICTED: similar to WHDC1-like protein 1 [Homo sa... 205 1e-52
gi|239745156 PREDICTED: similar to WAS protein homolog associate... 205 1e-52
gi|239745125 PREDICTED: similar to WAS protein homolog associate... 204 2e-52
gi|239752626 PREDICTED: hypothetical protein XP_002347872 [Homo ... 79 2e-14
gi|46852390 coiled-coil domain containing 6 [Homo sapiens] 73 1e-12
gi|47132519 Ras association and pleckstrin homology domains 1 is... 70 8e-12
gi|150170670 piccolo isoform 2 [Homo sapiens] 70 1e-11
gi|150378539 piccolo isoform 1 [Homo sapiens] 70 1e-11
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 68 4e-11
gi|13699803 WAS protein family, member 3 [Homo sapiens] 66 1e-10
gi|56549694 enabled homolog isoform a [Homo sapiens] 65 2e-10
gi|39930375 enabled homolog isoform b [Homo sapiens] 65 2e-10
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 64 6e-10
gi|149944526 additional sex combs like 3 [Homo sapiens] 63 1e-09
gi|52485606 formin-like 2 [Homo sapiens] 60 8e-09
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 60 8e-09
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 59 1e-08
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 57 5e-08
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 57 5e-08
gi|187761324 shootin1 isoform a [Homo sapiens] 57 5e-08
gi|55741677 SET domain containing 1A [Homo sapiens] 57 7e-08
gi|158534059 formin binding protein 4 [Homo sapiens] 57 9e-08
gi|33356148 formin-like 1 [Homo sapiens] 56 1e-07
gi|194294554 SET binding protein 1 isoform a [Homo sapiens] 56 2e-07
gi|158420731 chromodomain helicase DNA binding protein 3 isoform... 55 2e-07
>gi|122937271 WAS protein homolog associated with actin, golgi
membranes and microtubules [Homo sapiens]
Length = 809
Score = 1635 bits (4234), Expect = 0.0
Identities = 809/809 (100%), Positives = 809/809 (100%)
Query: 1 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR 60
MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
Sbjct: 1 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR 60
Query: 61 LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW 120
LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
Sbjct: 61 LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW 120
Query: 121 GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE 180
GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
Sbjct: 121 GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE 180
Query: 181 SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ 240
SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
Sbjct: 181 SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ 240
Query: 241 YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV 300
YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
Sbjct: 241 YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV 300
Query: 301 NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH 360
NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
Sbjct: 301 NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH 360
Query: 361 KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR 420
KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
Sbjct: 361 KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR 420
Query: 421 LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA 480
LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
Sbjct: 421 LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA 480
Query: 481 SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ 540
SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ
Sbjct: 481 SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ 540
Query: 541 RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE 600
RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE
Sbjct: 541 RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE 600
Query: 601 AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR 660
AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR
Sbjct: 601 AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR 660
Query: 661 ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG 720
ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG
Sbjct: 661 ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG 720
Query: 721 RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS 780
RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS
Sbjct: 721 RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS 780
Query: 781 IKAALQRIKRVSADSEEDSDEQDPGQWDG 809
IKAALQRIKRVSADSEEDSDEQDPGQWDG
Sbjct: 781 IKAALQRIKRVSADSEEDSDEQDPGQWDG 809
>gi|195947369 junction-mediating and regulatory protein [Homo
sapiens]
Length = 988
Score = 456 bits (1173), Expect = e-128
Identities = 287/788 (36%), Positives = 420/788 (53%), Gaps = 56/788 (7%)
Query: 63 PEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAWGL 122
P P + E+ SWAGL S LR H+QL ++ LE C P P E
Sbjct: 214 PPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPS--------- 264
Query: 123 GLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADC-ES 181
G+W +L+ E + LC QL+ YLG D CG + LF + ES
Sbjct: 265 --GMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYES 322
Query: 182 PREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQY 241
E R++ A R+++++ H +MV L+++YQ EDEAY L T +QY
Sbjct: 323 LSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQY 382
Query: 242 LLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVN 301
LLQPFR MRE+A L + I S++ D LGPRR+ +L+KE +W R+A AV+SIQD+TV
Sbjct: 383 LLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVK 442
Query: 302 YFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHK 361
YF+ T KA + M D K+FG+A+WA A R+EKLQ +++ETLQ+MRAKE+CL +
Sbjct: 443 YFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQR 502
Query: 362 RAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRL 421
+ ++ +M+ L + +D+LE +Y++QL+LYEV+FEILK EE+LLT QL+S+KRL
Sbjct: 503 KHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRL 562
Query: 422 IKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRAS 481
I EK+DEVVYYD E+ E + + + + E+++L+++ +QLE++RGR+ AK++
Sbjct: 563 ISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSY 622
Query: 482 LRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQR 541
LR++K+ C H ++QQ R HH++Q+KR+K+ +EE++K W++QERQ+TL R
Sbjct: 623 LRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDR 682
Query: 542 LRSFKDK------------RLAQSVRNTSGS----EPVAPNLPSDLSQQMCLPASHAVSV 585
LR+FK + RLA + R + S E +LPS L + V
Sbjct: 683 LRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRV 742
Query: 586 IHPSSRKTRGVPLSEAGNVK-------SPKCQNCHGNIPVQVFVPVGD---QTHSKSSEE 635
S+ T L + + S +P + +P+ + + S +
Sbjct: 743 KRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINP 802
Query: 636 LSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNL------GFRAPVKDDQPRPLV 689
L P PP PPPPPPPPPPPPPPPL S ++L R P P +
Sbjct: 803 LPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHL 862
Query: 690 CES--------PAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRP-PHASIN 740
+S + + L+ MDEVLASL+ G L+KVE + P P +
Sbjct: 863 FDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDS 922
Query: 741 EHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSD 800
+ILA IR+GVKLKKV D+ T T L RSI AL+RIK S +SE++ +
Sbjct: 923 NNILAQIRKGVKLKKVQKDV---LRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEE 979
Query: 801 EQDPGQWD 808
W+
Sbjct: 980 ALPCTDWE 987
Score = 63.9 bits (154), Expect = 6e-10
Identities = 31/57 (54%), Positives = 40/57 (70%), Gaps = 4/57 (7%)
Query: 12 WVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRL----REGARLGPE 64
WV VR +F E E+H+ F+VAWN EGKFA+TCH+RTAQ++R + GAR G E
Sbjct: 13 WVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGARGGAE 69
>gi|239745123 PREDICTED: hypothetical protein XP_002343373 [Homo
sapiens]
Length = 205
Score = 302 bits (773), Expect = 9e-82
Identities = 154/209 (73%), Positives = 162/209 (77%), Gaps = 21/209 (10%)
Query: 1 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR 60
MEDEQ DSLEGW PVR+GLFA+ ERHRLRFLVAWNGAEGK AVTCHD TAQQ + REGAR
Sbjct: 1 MEDEQLDSLEGWAPVRQGLFADAERHRLRFLVAWNGAEGKLAVTCHDLTAQQPQRREGAR 60
Query: 61 LGPEPEPKPE-----------------AAVSPSSWAGLLSAAGLRGAHRQLAALWPPLER 103
LG EP+PK AAV P +WAG SAAG RGA QLAALWPPLER
Sbjct: 61 LGLEPKPKAAVSPPSCRVPAQLPCPRPAAVFPPNWAGRFSAAGFRGARWQLAALWPPLER 120
Query: 104 CFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGA 163
C P+LDVGGGGAW LGLGLWALLW RAGPGE ALQELCGQLERYLGAAA GCGGA
Sbjct: 121 C----SPQLDVGGGGAWSLGLGLWALLWQARAGPGEVALQELCGQLERYLGAAAHGCGGA 176
Query: 164 TVRDALFPAEGGAADCESPREFRERALRA 192
TVR A+F A+G AADCESPREFRERALRA
Sbjct: 177 TVRHAVFAAKGRAADCESPREFRERALRA 205
>gi|239745158 PREDICTED: hypothetical protein XP_002343376 [Homo
sapiens]
Length = 156
Score = 251 bits (642), Expect = 1e-66
Identities = 131/192 (68%), Positives = 137/192 (71%), Gaps = 36/192 (18%)
Query: 1 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR 60
MEDEQ DSLEGW PVR+GLFA+ ERHRLRFLVAWNGAE
Sbjct: 1 MEDEQLDSLEGWAPVRQGLFADAERHRLRFLVAWNGAE---------------------- 38
Query: 61 LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW 120
AAV P +WAG SAAG RGA QLAALWPPLERC P+LDVGGGGAW
Sbjct: 39 ----------AAVFPPNWAGRFSAAGFRGARWQLAALWPPLERC----SPQLDVGGGGAW 84
Query: 121 GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE 180
LGLGLWALLW RAGPGE ALQELCGQLERYLGAAA GCGGATVR A+F A+G AADCE
Sbjct: 85 SLGLGLWALLWQARAGPGEVALQELCGQLERYLGAAAHGCGGATVRHAVFAAKGRAADCE 144
Query: 181 SPREFRERALRA 192
SPREFRERALRA
Sbjct: 145 SPREFRERALRA 156
>gi|169208040 PREDICTED: similar to WAS protein homolog associated
with actin, golgi membranes and microtubules isoform 1
[Homo sapiens]
Length = 131
Score = 239 bits (609), Expect = 1e-62
Identities = 121/129 (93%), Positives = 125/129 (96%)
Query: 313 MQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDL 372
MQKEMEQD KRFGQAAWATAIPRLEKL+LMLA+ETLQLMRAKEL LN KRAEIQGKMEDL
Sbjct: 1 MQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELYLNRKRAEIQGKMEDL 60
Query: 373 PEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYY 432
PEQEKN NVVDELE+QFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYY
Sbjct: 61 PEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYY 120
Query: 433 DPCENPEEL 441
DPCE+PEEL
Sbjct: 121 DPCESPEEL 129
>gi|169208753 PREDICTED: similar to WHDC1-like protein 1 [Homo
sapiens]
Length = 130
Score = 205 bits (522), Expect = 1e-52
Identities = 108/129 (83%), Positives = 118/129 (91%), Gaps = 1/129 (0%)
Query: 297 DITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKEL 356
+ +V +K+ + L GMQKEMEQD KRFGQAAWATAIPRLEKL+LMLA+ETLQLMRAKEL
Sbjct: 2 EASVPKYKKQLPQL-GMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKEL 60
Query: 357 CLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLD 416
LN KRAEIQGKMEDLPEQEKN NVVDELE+QFYEIQLELYEVKFEILKNEEILLTTQLD
Sbjct: 61 YLNRKRAEIQGKMEDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLD 120
Query: 417 SLKRLIKEK 425
SLKRLIK++
Sbjct: 121 SLKRLIKDE 129
>gi|239745156 PREDICTED: similar to WAS protein homolog associated
with actin, golgi membranes and microtubules isoform 2
[Homo sapiens]
Length = 130
Score = 205 bits (522), Expect = 1e-52
Identities = 108/129 (83%), Positives = 118/129 (91%), Gaps = 1/129 (0%)
Query: 297 DITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKEL 356
+ +V +K+ + L GMQKEMEQD KRFGQAAWATAIPRLEKL+LMLA+ETLQLMRAKEL
Sbjct: 2 EASVPKYKKQLPQL-GMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKEL 60
Query: 357 CLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLD 416
LN KRAEIQGKMEDLPEQEKN NVVDELE+QFYEIQLELYEVKFEILKNEEILLTTQLD
Sbjct: 61 YLNRKRAEIQGKMEDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLD 120
Query: 417 SLKRLIKEK 425
SLKRLIK++
Sbjct: 121 SLKRLIKDE 129
>gi|239745125 PREDICTED: similar to WAS protein homolog associated
with actin, golgi membranes and microtubules [Homo
sapiens]
Length = 130
Score = 204 bits (520), Expect = 2e-52
Identities = 108/129 (83%), Positives = 117/129 (90%), Gaps = 1/129 (0%)
Query: 297 DITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKEL 356
+ +V +K+ + L GMQKEMEQD KRFGQAAWATAIPRLEKL+LMLA+ETLQLMRAKEL
Sbjct: 2 EASVPKYKKQLPQL-GMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKEL 60
Query: 357 CLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLD 416
LN KRAEIQGKMEDLPEQEKN NVVDELE+QFYEIQLELYEVKFEILKNEEILLTTQLD
Sbjct: 61 YLNRKRAEIQGKMEDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLD 120
Query: 417 SLKRLIKEK 425
SLKRLIK +
Sbjct: 121 SLKRLIKNE 129
>gi|239752626 PREDICTED: hypothetical protein XP_002347872 [Homo
sapiens]
Length = 43
Score = 78.6 bits (192), Expect = 2e-14
Identities = 39/42 (92%), Positives = 40/42 (95%)
Query: 214 MVALMNVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATL 255
MVALM VYQEEDEAYQELVTVAT FFQYLL+PFRAMREVATL
Sbjct: 1 MVALMKVYQEEDEAYQELVTVATTFFQYLLRPFRAMREVATL 42
>gi|46852390 coiled-coil domain containing 6 [Homo sapiens]
Length = 474
Score = 72.8 bits (177), Expect = 1e-12
Identities = 94/424 (22%), Positives = 167/424 (39%), Gaps = 71/424 (16%)
Query: 279 KEAEEWTRRAEEAVVSIQ---DITVNYFKETV-KALAGMQKEMEQDAKRFGQAAWATAIP 334
K +E R +A V+IQ + + T+ K + +QKE E A +
Sbjct: 85 KALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNY---------- 134
Query: 335 RLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNV--VDELEIQFYEI 392
EK + L E + K + L H++AE++ +E E + N + + +LE
Sbjct: 135 --EKEEEFLTNE----LSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISK 188
Query: 393 QLELYEVKFEILKNEEILLTTQ-------------LDSLKRLIKEKQDEVVYYDPCENPE 439
QL L +++ E + E L Q L++ KR+++EK D+ V P
Sbjct: 189 QLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDI 248
Query: 440 ELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQ 499
+++ D ++ +R ++E + ++ A + + Q E R
Sbjct: 249 SMEI--------DSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEER---HM 297
Query: 500 AEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSG 559
EE++R R+ +R+ + + + + + + ++ + AQ +R +
Sbjct: 298 REENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMS-------AQGLRPRTV 350
Query: 560 SEPVAPNLPSDLSQQMCLP----ASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGN 615
S P+ P PS S + P ASH V P+S G+ + + HG
Sbjct: 351 SSPI-PYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHG- 408
Query: 616 IPVQVFVPVGDQTHSKSSEELSLPPPPPPP------PPPPPPPPPPPPPLRALSSSSQAA 669
+ S S ++ P PPP P PPPPPPPPP P +++SQ
Sbjct: 409 ------ITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPT 462
Query: 670 THQN 673
Q+
Sbjct: 463 PSQH 466
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 70.1 bits (170), Expect = 8e-12
Identities = 65/231 (28%), Positives = 93/231 (40%), Gaps = 42/231 (18%)
Query: 509 QHHSIQMKRDKIK----EEEQKKKEWINQER------------QKTLQRLRSFKD-KRLA 551
+H IQ K IK ++ + +W+N R Q+ L+R S D L+
Sbjct: 471 KHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLS 530
Query: 552 QSVRNTSGSEPVAPNLPSDLSQQM------CLPASHA-----VSVIHPSSRKTRGVPLSE 600
S + S P S+ S Q PA H VS + + K RG L E
Sbjct: 531 SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWK-RGTQLEE 589
Query: 601 AGNVKSPKCQNCHGN-IPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPL 659
+ + + + +P P ++ S LPPPPPPPPPPPPPPPPPPPPL
Sbjct: 590 SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL 649
Query: 660 RALSSSSQAATH------------QNLGFRAPVKDDQPRPLVCESPAERPR 698
+ S+ S + QN + P P V +S + +P+
Sbjct: 650 PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQ 700
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/123 (28%), Positives = 47/123 (38%), Gaps = 7/123 (5%)
Query: 617 PVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPP---PPPLRALSSSSQAATHQN 673
P + VP D L PPPPP P P PPPPPPP P P ++ S + + +
Sbjct: 906 PSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSS 965
Query: 674 LGFRAPVKDDQPRPLV-CESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAV 732
G + P Q + S AE P S S+ +P ++ P
Sbjct: 966 PGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVD---SLVSKFTPPAESGSPSKETLPPPA 1022
Query: 733 RPP 735
PP
Sbjct: 1023 APP 1025
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/256 (24%), Positives = 88/256 (34%), Gaps = 42/256 (16%)
Query: 562 PVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVF 621
P P +P+ L Q P V++ P+S KT +++A P
Sbjct: 764 PPPPPIPAPLPPQA--PPKPLVTIPAPTSTKTVAPVVTQAA--------------PPTPT 807
Query: 622 VPVGDQTHSKSSEELSLPPPPPPPPPPPPPP----------PPPPPPLRALSS-SSQAAT 670
PV + +PP PP PP P PPP PPP PL + S Q A+
Sbjct: 808 PPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIAS 867
Query: 671 HQNLGFRAPVKDDQP-RPLVC-----ESPAERPRDSLESFSCPGSMDEV-----LASLRH 719
P + QP +P+ PA + + + S P + +SL
Sbjct: 868 QFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVF 927
Query: 720 GRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLER 779
P V P PP + + G KK P P + +R S ++
Sbjct: 928 PPPPPSPVPAPPPPPPPTASP----TPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS 983
Query: 780 SIKAALQRIKRVSADS 795
S A KR S DS
Sbjct: 984 SSGAEHPEPKRPSVDS 999
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/141 (26%), Positives = 47/141 (33%), Gaps = 34/141 (24%)
Query: 627 QTHSKSSEELSLPPPPPP------------PP----PPPPPPPPPPPPLRALSSSSQAAT 670
Q S+ S L PP PP PP PPPPPPPPPP P A++ A
Sbjct: 674 QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPC 733
Query: 671 H------------------QNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDE 712
Q++ AP P P+ P + P L + P S
Sbjct: 734 APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKT 793
Query: 713 VLASLRHGRAPLRKVEVPAVR 733
V + P VP +
Sbjct: 794 VAPVVTQAAPPTPTPPVPPAK 814
Score = 38.5 bits (88), Expect = 0.025
Identities = 20/56 (35%), Positives = 25/56 (44%)
Query: 639 PPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPA 694
PPPPPP P P PP PP P + + +S + AP P P + PA
Sbjct: 763 PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPA 818
Score = 33.5 bits (75), Expect = 0.81
Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 11/113 (9%)
Query: 553 SVRNTSGSEPVAPNLPS--DLSQQMCLPA---SHAVSVIHPSSRKTRGVPLSEAG-NVKS 606
S++++SG+E P PS L + PA S + + P + + L+ +G N+
Sbjct: 980 SIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPG 1039
Query: 607 PKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPL 659
Q C V PV S E PP PPPPP P PP+
Sbjct: 1040 VLQQGC-----VSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPI 1087
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 69.7 bits (169), Expect = 1e-11
Identities = 47/140 (33%), Positives = 67/140 (47%), Gaps = 12/140 (8%)
Query: 520 IKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSG-SEPVAPNLPSDLSQQMCLP 578
I E++ KK L+ L +++DK+ ++ R S SE V + PS + + LP
Sbjct: 2295 ISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSV---IALP 2351
Query: 579 ASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSL 638
+S + +S +T G + P Q G+ V SS ++S
Sbjct: 2352 MKEQLSTTYFTSGETFGQ--------EKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISA 2403
Query: 639 PPPPPPPPPPPPPPPPPPPP 658
PPPPPPPPPPPPPPPPPPP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPP 2423
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 4/115 (3%)
Query: 597 PLSEAGNVKSPKCQNCHGNIPVQVFVP---VGDQTH-SKSSEELSLPPPPPPPPPPPPPP 652
P G K+P Q G IP Q P QT +K +L P PPP P P P
Sbjct: 430 PAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKP 489
Query: 653 PPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCP 707
PP P S +T P K +P + P+++P + S P
Sbjct: 490 PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544
Score = 31.6 bits (70), Expect = 3.1
Identities = 42/177 (23%), Positives = 55/177 (31%), Gaps = 28/177 (15%)
Query: 539 LQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPL 598
LQR S + A VR E V P+LPS + P P K++ P
Sbjct: 274 LQRDASRPQTKQADIVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 329
Query: 599 S--------------EAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPP 644
+ G VK P P Q P SE+ S P P
Sbjct: 330 KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPK 389
Query: 645 PPPPPP--------PPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESP 693
PP P P PP + + + A Q G ++P K P + P
Sbjct: 390 ALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA--QQPGLQSPAKAPGPTKTPVQQP 444
Score = 31.2 bits (69), Expect = 4.0
Identities = 18/69 (26%), Positives = 34/69 (49%), Gaps = 11/69 (15%)
Query: 750 GVKLKKVHPDLGPNPSSKPTSNRRTSD----------LERSIKAALQRIKRVSADSEEDS 799
G K++ + D+G N + P S ++ D +RS + +R K+ S D+ +
Sbjct: 3416 GAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKK-SVDTSVQT 3474
Query: 800 DEQDPGQWD 808
D++D +WD
Sbjct: 3475 DDEDQDEWD 3483
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 69.7 bits (169), Expect = 1e-11
Identities = 47/140 (33%), Positives = 67/140 (47%), Gaps = 12/140 (8%)
Query: 520 IKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSG-SEPVAPNLPSDLSQQMCLP 578
I E++ KK L+ L +++DK+ ++ R S SE V + PS + + LP
Sbjct: 2295 ISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSV---IALP 2351
Query: 579 ASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSL 638
+S + +S +T G + P Q G+ V SS ++S
Sbjct: 2352 MKEQLSTTYFTSGETFGQ--------EKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISA 2403
Query: 639 PPPPPPPPPPPPPPPPPPPP 658
PPPPPPPPPPPPPPPPPPP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPP 2423
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 4/115 (3%)
Query: 597 PLSEAGNVKSPKCQNCHGNIPVQVFVP---VGDQTH-SKSSEELSLPPPPPPPPPPPPPP 652
P G K+P Q G IP Q P QT +K +L P PPP P P P
Sbjct: 430 PAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKP 489
Query: 653 PPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCP 707
PP P S +T P K +P + P+++P + S P
Sbjct: 490 PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544
Score = 31.6 bits (70), Expect = 3.1
Identities = 42/177 (23%), Positives = 55/177 (31%), Gaps = 28/177 (15%)
Query: 539 LQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPL 598
LQR S + A VR E V P+LPS + P P K++ P
Sbjct: 274 LQRDASRPQTKQADIVRG----ESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 329
Query: 599 S--------------EAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPP 644
+ G VK P P Q P SE+ S P P
Sbjct: 330 KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPK 389
Query: 645 PPPPPP--------PPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESP 693
PP P P PP + + + A Q G ++P K P + P
Sbjct: 390 ALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA--QQPGLQSPAKAPGPTKTPVQQP 444
Score = 31.2 bits (69), Expect = 4.0
Identities = 18/69 (26%), Positives = 34/69 (49%), Gaps = 11/69 (15%)
Query: 750 GVKLKKVHPDLGPNPSSKPTSNRRTSD----------LERSIKAALQRIKRVSADSEEDS 799
G K++ + D+G N + P S ++ D +RS + +R K+ S D+ +
Sbjct: 3416 GAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKK-SVDTSVQT 3474
Query: 800 DEQDPGQWD 808
D++D +WD
Sbjct: 3475 DDEDQDEWD 3483
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 67.8 bits (164), Expect = 4e-11
Identities = 63/194 (32%), Positives = 85/194 (43%), Gaps = 39/194 (20%)
Query: 639 PPPPP-------PPPPPPP------PPPPP----PPPLRALSSSSQAA------THQNLG 675
PPPPP PPPPPP PPPPP PPP AL SS+ + + +G
Sbjct: 310 PPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVG 369
Query: 676 FRAPVKDDQPRPLVCESPAERPRDSLESF------SCPGSMDEVLASLRHGRAPLRKVEV 729
AP P P P P L S + G+ +L +R G A L+KVE
Sbjct: 370 PVAPPPPPPPPP----PPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREG-AQLKKVEQ 424
Query: 730 PAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIK 789
+ RP S + +L IRQG++LK V S P + TS + ++ +Q+
Sbjct: 425 NS-RPVSCSGRDALLDQIRQGIQLKSV----ADGQESTPPTPAPTSGIVGALMEVMQKRS 479
Query: 790 RVSADSEEDSDEQD 803
+ S+ED DE D
Sbjct: 480 KAIHSSDEDEDEDD 493
>gi|13699803 WAS protein family, member 3 [Homo sapiens]
Length = 502
Score = 65.9 bits (159), Expect = 1e-10
Identities = 94/381 (24%), Positives = 138/381 (36%), Gaps = 93/381 (24%)
Query: 478 KRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQK 537
K L+ +D+ KE R + Q+ + + K+++ +++EW K
Sbjct: 162 KEKMLQDTEDKRKEKRRQKEQKRIDGTTREVK---------KVRKARNRRQEWNMMAYDK 212
Query: 538 TLQRLRSFKDKRLAQSVRNTSGSE-PVAPNLPSDLSQ--QMCLPASHAVSVIHPSSRKTR 594
L+ D RL+QSV + + SE ++P+ S S PA+ S +HP
Sbjct: 213 ELR-----PDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHS-LHPQPV--- 263
Query: 595 GVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPP---- 650
P AG+V HG P + S S+ ++L P PPPPPPP
Sbjct: 264 -TPSYAAGDVPP------HG--PASQAAEHEYRPPSASARHMALNRPQQPPPPPPPQAPE 314
Query: 651 -----------------------------PPPPPPP---------------PLRALSSSS 666
PPPPPPP P++ +S
Sbjct: 315 GSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPPFPAS 374
Query: 667 QAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRK 726
++TH AP LV P P PGS + +S HG
Sbjct: 375 ASSTHA-----APPHPPSTGLLVTAPPPPGPPPPPPGPPGPGS--SLSSSPMHGPPVAEA 427
Query: 727 VEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQ 786
+PP + +LAAIR G++LKKV +P N + L R
Sbjct: 428 KRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR------- 480
Query: 787 RIKRVSADSEEDSDEQDPGQW 807
RI +DS++DS E D W
Sbjct: 481 RIAVEYSDSDDDS-EFDENDW 500
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/295 (24%), Positives = 125/295 (42%), Gaps = 72/295 (24%)
Query: 372 LPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVY 431
LP Q +N +ELEIQ ++Q + + + E + E + + +RL +E+ +
Sbjct: 127 LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER--- 183
Query: 432 YDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKE 491
+ LE ++L R+ Q+ E R R+++ +
Sbjct: 184 ----------------------ERLEQEQLERERQERE---------RQERLERQERLER 212
Query: 492 NHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQR--LRSFKDKR 549
R Q+ + R RQ +R++++ E++++E +ERQ+ L+R L +++R
Sbjct: 213 QERLERQERLDRERQERQ------ERERLERLERERQE---RERQEQLEREQLEWERERR 263
Query: 550 LAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKC 609
++ + S P+ L + + L A+ P+ S+ G V P
Sbjct: 264 ISSAAAPASVETPLNSVLGDSSASEPGLQAAS-----QPAETP------SQQGIVLGPLA 312
Query: 610 QNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPP-----PPPPPPPPPL 659
P +P G + ++LPPPP PPPPPP PPPPPPPPPL
Sbjct: 313 P------PPPPPLPPG-----PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPL 356
Score = 45.1 bits (105), Expect = 3e-04
Identities = 86/394 (21%), Positives = 144/394 (36%), Gaps = 93/394 (23%)
Query: 451 QDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRF---RLQQAE-ESIRY 506
Q++ ++ ++L+ Q +Q E +R R+ +R + + E R RL+Q + E R
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 507 SRQHHSIQMKRDKIKEEEQ-KKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAP 565
R+ ++++++ +E+ +++E +++ERQ+ +R R +RL + + E +
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERL---ERLERERQERERQEQLER 253
Query: 566 NLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVG 625
++ A+ SV P + SE G + + P Q + +G
Sbjct: 254 EQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQ----PAETPSQQGIVLG 309
Query: 626 DQTHSKSSEELSLPPPPPPPPPPPP------------PPPPPPPPLRALSSSSQAATHQN 673
P PPPPPP PPPP PPP L S+
Sbjct: 310 ----------------PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPST-------- 345
Query: 674 LGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVR 733
P P PL + P P G LAS+ PL
Sbjct: 346 ----GPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFF---LASMSEDNRPLTG------- 391
Query: 734 PPHASINEHILAAIRQGVKLKKVH-----------PDLGPNPSSKPTSNRR--------T 774
LAA G KL+KV +G N +S T R
Sbjct: 392 ----------LAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGG 441
Query: 775 SDLERSIKAALQRIKRVS--ADSEEDSDEQDPGQ 806
S L + A L R +R++ + E ++D G+
Sbjct: 442 SGLMEEMSALLARRRRIAEKGSTIETEQKEDKGE 475
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/295 (24%), Positives = 125/295 (42%), Gaps = 72/295 (24%)
Query: 372 LPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVY 431
LP Q +N +ELEIQ ++Q + + + E + E + + +RL +E+ +
Sbjct: 127 LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER--- 183
Query: 432 YDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKE 491
+ LE ++L R+ Q+ E R R+++ +
Sbjct: 184 ----------------------ERLEQEQLERERQERE---------RQERLERQERLER 212
Query: 492 NHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQR--LRSFKDKR 549
R Q+ + R RQ +R++++ E++++E +ERQ+ L+R L +++R
Sbjct: 213 QERLERQERLDRERQERQ------ERERLERLERERQE---RERQEQLEREQLEWERERR 263
Query: 550 LAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKC 609
++ + S P+ L + + L A+ P+ S+ G V P
Sbjct: 264 ISSAAAPASVETPLNSVLGDSSASEPGLQAAS-----QPAETP------SQQGIVLGPLA 312
Query: 610 QNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPP-----PPPPPPPPPL 659
P +P G + ++LPPPP PPPPPP PPPPPPPPPL
Sbjct: 313 P------PPPPPLPPG-----PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPL 356
Score = 45.1 bits (105), Expect = 3e-04
Identities = 86/394 (21%), Positives = 144/394 (36%), Gaps = 93/394 (23%)
Query: 451 QDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRF---RLQQAE-ESIRY 506
Q++ ++ ++L+ Q +Q E +R R+ +R + + E R RL+Q + E R
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 507 SRQHHSIQMKRDKIKEEEQ-KKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAP 565
R+ ++++++ +E+ +++E +++ERQ+ +R R +RL + + E +
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERL---ERLERERQERERQEQLER 253
Query: 566 NLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVG 625
++ A+ SV P + SE G + + P Q + +G
Sbjct: 254 EQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQ----PAETPSQQGIVLG 309
Query: 626 DQTHSKSSEELSLPPPPPPPPPPPP------------PPPPPPPPLRALSSSSQAATHQN 673
P PPPPPP PPPP PPP L S+
Sbjct: 310 ----------------PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPST-------- 345
Query: 674 LGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVR 733
P P PL + P P G LAS+ PL
Sbjct: 346 ----GPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFF---LASMSEDNRPLTG------- 391
Query: 734 PPHASINEHILAAIRQGVKLKKVH-----------PDLGPNPSSKPTSNRR--------T 774
LAA G KL+KV +G N +S T R
Sbjct: 392 ----------LAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGG 441
Query: 775 SDLERSIKAALQRIKRVS--ADSEEDSDEQDPGQ 806
S L + A L R +R++ + E ++D G+
Sbjct: 442 SGLMEEMSALLARRRRIAEKGSTIETEQKEDKGE 475
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 63.9 bits (154), Expect = 6e-10
Identities = 47/145 (32%), Positives = 61/145 (42%), Gaps = 33/145 (22%)
Query: 623 PVGDQTHSKSSEELSLPP----PPPPPPPPPPPPPPPPPPLRALSSS------------- 665
P G + +SE+ LPP PPPP PPPPPPPPPPPPPL L++S
Sbjct: 225 PGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWST 284
Query: 666 --SQAATHQNLGFRAPVKDDQ----PRPLVCESP---AERPRDSLESFSCPGSMDEVLAS 716
A + G P + +Q P P +P A P L + PG +
Sbjct: 285 LHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGA 344
Query: 717 LRHGRAPLRKVEVPAVRPPHASINE 741
HG +PA RPP + + E
Sbjct: 345 ESHGC-------LPATRPPGSDLRE 362
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/74 (40%), Positives = 38/74 (51%), Gaps = 14/74 (18%)
Query: 628 THSKSSEELSLPPPPPPPPPP----PPP----PPPPPPP-----LRALSSSSQAATHQNL 674
T + + EE PPP PPPPP PPP PPPPPPP L++L+S + +
Sbjct: 760 TTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYR 819
Query: 675 GFRAPVKDDQPRPL 688
G A V +P PL
Sbjct: 820 GTGAAV-STRPGPL 832
Score = 43.5 bits (101), Expect = 8e-04
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 11/71 (15%)
Query: 628 THSKSSEELSLPPPPPPPPPPP-----------PPPPPPPPPLRALSSSSQAATHQNLGF 676
T + +++E PPP PPPPP PPPPPPP P L S + Q +
Sbjct: 759 TTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCY 818
Query: 677 RAPVKDDQPRP 687
R RP
Sbjct: 819 RGTGAAVSTRP 829
Score = 40.4 bits (93), Expect = 0.007
Identities = 23/63 (36%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 632 SSEELSLPPPPPPPPPPPPP----PPPPP-----PPLRALSSSSQAATHQNLGFRAPVKD 682
++ LSLPP P PPPPP P PPPPP P RA + G P +
Sbjct: 455 ATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRP 514
Query: 683 DQP 685
P
Sbjct: 515 APP 517
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/76 (35%), Positives = 34/76 (44%), Gaps = 17/76 (22%)
Query: 628 THSKS-SEELSLPPPP-----------PPPPPPPPPPPPPPPPLRALSSSSQAATHQNL- 674
+HS S + +S PPPP PP P P PP P AL + ++ HQN
Sbjct: 560 SHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTS 619
Query: 675 -GFRAPVKDDQPRPLV 689
FR P + PRP V
Sbjct: 620 GSFRRP---ESPRPRV 632
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/98 (29%), Positives = 36/98 (36%), Gaps = 35/98 (35%)
Query: 634 EELSLPPPPPPPPPPPPPP----------------------PPPPPPLRALSSSSQAATH 671
EEL PP P PPP P PP PP SS+S + +H
Sbjct: 502 EELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSH 561
Query: 672 QN-----LGFRAPVK-----DDQPRPLVCESPAERPRD 699
+ + F P D PRP SPA+ P+D
Sbjct: 562 SSSPAGPVSFPPPPYLARSIDPLPRP---PSPAQNPQD 596
Score = 31.6 bits (70), Expect = 3.1
Identities = 14/35 (40%), Positives = 15/35 (42%)
Query: 624 VGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPP 658
+G HS L P P PP P PPPPP
Sbjct: 438 LGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPP 472
>gi|149944526 additional sex combs like 3 [Homo sapiens]
Length = 2248
Score = 62.8 bits (151), Expect = 1e-09
Identities = 27/49 (55%), Positives = 33/49 (67%), Gaps = 4/49 (8%)
Query: 615 NIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPP----PPPPPPPPPL 659
N+P++ VG H+ ++ L PPPPPPPPPPP PPPPPPPPPL
Sbjct: 1993 NMPMKEGDEVGGTAHTMPNKALVHPPPPPPPPPPPPLALPPPPPPPPPL 2041
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 60.1 bits (144), Expect = 8e-09
Identities = 21/21 (100%), Positives = 21/21 (100%)
Query: 639 PPPPPPPPPPPPPPPPPPPPL 659
PPPPPPPPPPPPPPPPPPPPL
Sbjct: 554 PPPPPPPPPPPPPPPPPPPPL 574
Score = 59.3 bits (142), Expect = 1e-08
Identities = 20/21 (95%), Positives = 21/21 (100%)
Query: 638 LPPPPPPPPPPPPPPPPPPPP 658
+PPPPPPPPPPPPPPPPPPPP
Sbjct: 552 MPPPPPPPPPPPPPPPPPPPP 572
Score = 57.0 bits (136), Expect = 7e-08
Identities = 21/36 (58%), Positives = 25/36 (69%)
Query: 623 PVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPP 658
P D + + ++ P PPPPPPPPPPPPPPPPPP
Sbjct: 535 PSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPP 570
Score = 54.7 bits (130), Expect = 3e-07
Identities = 19/20 (95%), Positives = 19/20 (95%)
Query: 639 PPPPPPPPPPPPPPPPPPPP 658
PPPPPPPPPPPPPPPPPP P
Sbjct: 556 PPPPPPPPPPPPPPPPPPLP 575
Score = 51.2 bits (121), Expect = 4e-06
Identities = 18/20 (90%), Positives = 18/20 (90%)
Query: 639 PPPPPPPPPPPPPPPPPPPP 658
PPPPPPPPPPPPPPPP P P
Sbjct: 558 PPPPPPPPPPPPPPPPLPGP 577
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/62 (41%), Positives = 28/62 (45%), Gaps = 16/62 (25%)
Query: 639 PPPPPPPPPPPPPPP---------------PPPPPLRALSSSSQAATHQNLGFRAPVKDD 683
PPPPPPPPPPPPPPP PP P L +S N G A VK
Sbjct: 559 PPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGL-AAVKIK 617
Query: 684 QP 685
+P
Sbjct: 618 KP 619
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/65 (35%), Positives = 26/65 (40%), Gaps = 20/65 (30%)
Query: 614 GNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPP--------------------PPPPPPP 653
G + + V G+ S P PPPPPP PPPPPPP
Sbjct: 500 GTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP 559
Query: 654 PPPPP 658
PPPPP
Sbjct: 560 PPPPP 564
>gi|21071077 dishevelled-associated activator of morphogenesis 1
[Homo sapiens]
Length = 1078
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/169 (29%), Positives = 74/169 (43%), Gaps = 33/169 (19%)
Query: 498 QQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNT 557
Q E++ + ++H+ +Q K +K KE E K QE+++ +Q L K+K ++ +
Sbjct: 447 QWKEQAEKMRKEHNELQQKLEK-KERECDAK---TQEKEEMMQTLNKMKEKLEKETTEHK 502
Query: 558 SGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRG----VPLSEAGNVKSPKCQNCH 613
+ VA DL+ Q+ + AV P P S G++ P
Sbjct: 503 QVKQQVA-----DLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPP------ 551
Query: 614 GNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRAL 662
P +P G LPPPPPP PP PPPPP PPPL A+
Sbjct: 552 ---PPPPPLPGG-----------MLPPPPPPLPPGGPPPPPGPPPLGAI 586
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 59.3 bits (142), Expect = 1e-08
Identities = 30/66 (45%), Positives = 34/66 (51%), Gaps = 9/66 (13%)
Query: 633 SEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPR-PLVCE 691
S L PPP PPPPPPPPPPPPPPPP S+ Q + PV D P P +
Sbjct: 1987 STPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQV--------QLPVSLDLPLFPSIMM 2038
Query: 692 SPAERP 697
P + P
Sbjct: 2039 QPVQHP 2044
Score = 47.0 bits (110), Expect = 7e-05
Identities = 26/53 (49%), Positives = 29/53 (54%), Gaps = 5/53 (9%)
Query: 624 VGDQTHSKSSEELSLPPPPPPP---PPPPPPPPPPPPPLRALSSSSQAATHQN 673
+G T + SS LSL P P PPPPPPPPPPPP +L S Q QN
Sbjct: 3091 LGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSL--SGQQTEQQN 3141
Score = 44.3 bits (103), Expect = 5e-04
Identities = 23/72 (31%), Positives = 29/72 (40%)
Query: 640 PPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRD 699
PPPPPPPPP PP PP P + + + +T P P P P P
Sbjct: 1958 PPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPS 2017
Query: 700 SLESFSCPGSMD 711
+ P S+D
Sbjct: 2018 APPQVQLPVSLD 2029
Score = 43.1 bits (100), Expect = 0.001
Identities = 16/22 (72%), Positives = 16/22 (72%)
Query: 637 SLPPPPPPPPPPPPPPPPPPPP 658
S P PPPPPPPPP PP PP P
Sbjct: 1953 SSPETPPPPPPPPPLPPAPPQP 1974
Score = 37.7 bits (86), Expect = 0.043
Identities = 49/231 (21%), Positives = 89/231 (38%), Gaps = 30/231 (12%)
Query: 464 QCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSI-----QMKRD 518
Q Q L+ + + A + L+ +K Q + + QQ + S ++ +I Q+ +D
Sbjct: 1747 QLQILQQQAQQYQATQPQLQPQKQQQQPPPPQQQQQQQASKLLKQEQSNIVSADCQIMKD 1806
Query: 519 ----KIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQ 574
K E+ +K E QE + L+ KD + +S+ + +A + ++
Sbjct: 1807 VPSYKEAEDISEKPEKPKQEFISEGEGLKEGKDTKKQKSLEPSIPPPRIASGARGNAAKA 1866
Query: 575 MCLPASHAVSVIHPSSRKT--RGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTH--- 629
+ + + + +R+ + E N +C C G + V + Q H
Sbjct: 1867 LLENFGFELVIQYNENRQKVQKKGKSGEGENTDKLECGTC-GKLFSNVLILKSHQEHVHG 1925
Query: 630 ---------------SKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALSSS 665
++ ++L P P PPPPPPPPP PP SS
Sbjct: 1926 QFFPYAALEKFARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSS 1976
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/130 (33%), Positives = 55/130 (42%), Gaps = 15/130 (11%)
Query: 631 KSSEELSLPPPPPPPPP--------PPPPPPPPPPP---LRALSSSSQAATHQNLGFRAP 679
++ E+ + PPPPPPPP PPPPPPPPP P +AL ++ LG AP
Sbjct: 412 RALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAP 471
Query: 680 VKDDQPRPL--VCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAV-RPPH 736
P PL CE P L CP +L + G P +P PP
Sbjct: 472 PAPPLPPPLPGSCEF-LPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPV 530
Query: 737 ASINEHILAA 746
A E ++ A
Sbjct: 531 AGGMEEVIVA 540
Score = 37.4 bits (85), Expect = 0.056
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 38/236 (16%)
Query: 341 LMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNV-VDELEIQFYEIQLELYEV 399
L L R+ Q +A + L R+E ++ L E E+ + V E++ Q+ E
Sbjct: 816 LQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTE-------- 867
Query: 400 KFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVK 459
I LD L I++KQ E+ Y CE+ ++L + D ++ ++L ++
Sbjct: 868 ----RLQASISAFRALDELFEAIEQKQRELADY-LCEDAQQLSLEDTFSTMKAFRDLFLR 922
Query: 460 ELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDK 519
L+ + RK+Q + R + Q AEE R R +++
Sbjct: 923 ALKEN------------------KDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGP 964
Query: 520 IKEEEQKKKEWINQERQKTLQRLRSFKDK------RLAQSVRNTSGSEPVAPNLPS 569
K+EE + + + +K Q ++ + + A S+ +EPVA + P+
Sbjct: 965 GKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/130 (33%), Positives = 55/130 (42%), Gaps = 15/130 (11%)
Query: 631 KSSEELSLPPPPPPPPP--------PPPPPPPPPPP---LRALSSSSQAATHQNLGFRAP 679
++ E+ + PPPPPPPP PPPPPPPPP P +AL ++ LG AP
Sbjct: 412 RALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAP 471
Query: 680 VKDDQPRPL--VCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAV-RPPH 736
P PL CE P L CP +L + G P +P PP
Sbjct: 472 PAPPLPPPLPGSCEF-LPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPV 530
Query: 737 ASINEHILAA 746
A E ++ A
Sbjct: 531 AGGMEEVIVA 540
Score = 37.4 bits (85), Expect = 0.056
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 38/236 (16%)
Query: 341 LMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNV-VDELEIQFYEIQLELYEV 399
L L R+ Q +A + L R+E ++ L E E+ + V E++ Q+ E
Sbjct: 816 LQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTE-------- 867
Query: 400 KFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVK 459
I LD L I++KQ E+ Y CE+ ++L + D ++ ++L ++
Sbjct: 868 ----RLQASISAFRALDELFEAIEQKQRELADY-LCEDAQQLSLEDTFSTMKAFRDLFLR 922
Query: 460 ELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDK 519
L+ + RK+Q + R + Q AEE R R +++
Sbjct: 923 ALKEN------------------KDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGP 964
Query: 520 IKEEEQKKKEWINQERQKTLQRLRSFKDK------RLAQSVRNTSGSEPVAPNLPS 569
K+EE + + + +K Q ++ + + A S+ +EPVA + P+
Sbjct: 965 GKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 57.4 bits (137), Expect = 5e-08
Identities = 45/158 (28%), Positives = 77/158 (48%), Gaps = 16/158 (10%)
Query: 642 PPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSL 701
PPPPPPPPP PPPPP P+R+L S + +H + G A K+ +P E + R ++
Sbjct: 353 PPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPS-GSGAK-KEKATQPETTEEVTDLKRQAV 410
Query: 702 ESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLG 761
E MD + + H R P+ + P +P + E + +LK + L
Sbjct: 411 EEM-----MDRIKKGV-HLR-PVNQTARPKTKPESSKGCESAVD------ELKGILGTLN 457
Query: 762 PNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDS 799
+ SS+ + + E ++ L+R ++V+A+++ S
Sbjct: 458 KSTSSRSLKSLDPENSETELERILRR-RKVTAEADSSS 494
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/205 (25%), Positives = 79/205 (38%), Gaps = 29/205 (14%)
Query: 498 QQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWI---NQERQKTLQRLRSFKDKRLAQSV 554
+ ES+ ++ QH S+ + + + +E++ K ++ +E ++ + +D V
Sbjct: 474 ETTNESVPFA-QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDT--GSEV 530
Query: 555 RNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHG 614
+ SG P P P+ + + P P + TR P + N SP C +
Sbjct: 531 PSGSGHGPCTPP-PAPANFEDVAPTGSG----EPGA--TRESPKANGQNQASP-CSS--- 579
Query: 615 NIPVQVFVPVGDQTHSKSSEELSLPPPPPPPP--PPPPPPPPPPPPLRALSSSSQAATHQ 672
GD + PPP P PP PPPPPPPPPPPP S HQ
Sbjct: 580 ----------GDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQ 629
Query: 673 NLGFRAPVKDDQPRPLVCESPAERP 697
P D P P P P
Sbjct: 630 PAYLLPPRPDGPPPPEYPPPPPPPP 654
Score = 33.1 bits (74), Expect = 1.1
Identities = 46/222 (20%), Positives = 86/222 (38%), Gaps = 21/222 (9%)
Query: 451 QDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQH 510
+D++ + + R+ L+S+ G ++ +S S KD+ + + EE++ +++
Sbjct: 944 RDEERGKTQGKHRKSFALDSE-GEEASQESS--SEKDEEDDEEDEEDEDREEAVDTTKKE 1000
Query: 511 HSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSD 570
+ D+ + K + + + + S D + S ++S S + + S
Sbjct: 1001 TEVSDGEDEESDSSSKCSLYADSDGEND-----STSDSESSSSSSSSSSSSSSSSSSSSS 1055
Query: 571 LSQQMCLP---ASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGN----IPVQVFVP 623
S + + + +S R VP+ V+ P + G+ +P Q P
Sbjct: 1056 SSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
Query: 624 V---GDQTHSKSSEELSLPPPPPPPPPPPPPP---PPPPPPL 659
G S S L P PP PP P P P P P PL
Sbjct: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL 1157
Score = 32.3 bits (72), Expect = 1.8
Identities = 12/18 (66%), Positives = 13/18 (72%)
Query: 650 PPPPPPPPPLRALSSSSQ 667
PPPPPPPPP RA S+
Sbjct: 1403 PPPPPPPPPPRAYEPRSE 1420
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 639 PPPPPPPPPP 648
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 640 PPPPPPPPPP 649
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 641 PPPPPPPPPP 650
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 642 PPPPPPPPPP 651
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 643 PPPPPPPPPP 652
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 644 PPPPPPPPPP 653
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 645 PPPPPPPPPP 654
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 646 PPPPPPPPPP 655
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 647 PPPPPPPPPP 656
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 648 PPPPPPPPPP 657
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
Score = 31.6 bits (70), Expect = 3.1
Identities = 10/10 (100%), Positives = 10/10 (100%)
Query: 649 PPPPPPPPPP 658
PPPPPPPPPP
Sbjct: 1403 PPPPPPPPPP 1412
>gi|158534059 formin binding protein 4 [Homo sapiens]
Length = 1017
Score = 56.6 bits (135), Expect = 9e-08
Identities = 32/91 (35%), Positives = 41/91 (45%), Gaps = 7/91 (7%)
Query: 636 LSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAE 695
L +PPPPPPPP PPPPPPPPPP A Q ++ G P P P E
Sbjct: 709 LEMPPPPPPPPESPPPPPPPPPP--AEDGEIQEVEMEDEGSEEP-----PAPGTEEDTPL 761
Query: 696 RPRDSLESFSCPGSMDEVLASLRHGRAPLRK 726
+P + S+D ++S + RK
Sbjct: 762 KPSAQTTVVTSQSSVDSTISSSSSTKGIKRK 792
Score = 48.9 bits (115), Expect = 2e-05
Identities = 21/48 (43%), Positives = 29/48 (60%), Gaps = 4/48 (8%)
Query: 615 NIPVQVFVPVGDQTHSKSSEELS--LPPPPPPPPPPPPPPPPP--PPP 658
++P+ V P ++ + + + PPPPPPPPPPPPPP P PPP
Sbjct: 878 SVPIGVTAPSLQPVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPPP 925
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 56.2 bits (134), Expect = 1e-07
Identities = 73/300 (24%), Positives = 117/300 (39%), Gaps = 45/300 (15%)
Query: 377 KNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQ--LDSLKRLIKEKQDEVVYYDP 434
+N N L+ +F + L+LY + + +++++ + Q LD++ + +D
Sbjct: 338 ENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAV 397
Query: 435 CENPEELK--VIDCVVGLQDDKN---LEVKELRRQCQQ----LESKRGRICAKRASLRSR 485
E+ EEL+ V L+D +N ++ EL +Q Q LE+ R R A SR
Sbjct: 398 LEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASR 457
Query: 486 KDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSF 545
+ E ++ ++K EE ++K I R +
Sbjct: 458 RPPEPEKAPPAAPTRPSAL--------------ELKVEELEEKGLIRILRGPG----DAV 499
Query: 546 KDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASH-AVSVIHPSSRKTRGVPLSEAGNV 604
+ L +V SG + P +P+ PA+ A P G+P +
Sbjct: 500 SIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPP 559
Query: 605 KSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPP------PPPPPPPPP 658
+P P +P + LPPPPPPPPPPP PPPPPPPPP
Sbjct: 560 SAP---------PQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPP 610
Score = 40.0 bits (92), Expect = 0.009
Identities = 14/17 (82%), Positives = 14/17 (82%)
Query: 639 PPPPPPPPPPPPPPPPP 655
P PPPPPPPPPPP PP
Sbjct: 600 PVPPPPPPPPPPPGGPP 616
Score = 33.9 bits (76), Expect = 0.62
Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 9/76 (11%)
Query: 616 IPVQVFVPVGDQTHSKS----SEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATH 671
+PV V P G + S L P P P PPPPPP P L + + +A
Sbjct: 504 LPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPP 563
Query: 672 QNLGFRAPVKDDQPRP 687
Q AP P P
Sbjct: 564 Q-----APPLPGSPEP 574
>gi|194294554 SET binding protein 1 isoform a [Homo sapiens]
Length = 1596
Score = 55.8 bits (133), Expect = 2e-07
Identities = 31/77 (40%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 638 LPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERP 697
LPPPPPPP PPPPPPP PPPP + H+ +AP + Q P P E
Sbjct: 1522 LPPPPPPPLPPPPPPPLPPPPPLPKTPRGGKRKHKP---QAPAQPPQQSPPQQPLPQEEE 1578
Query: 698 RDSLESFSCPGSMDEVL 714
+ GS EVL
Sbjct: 1579 VKAKRQRKSRGSESEVL 1595
>gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3
[Homo sapiens]
Length = 2059
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/83 (42%), Positives = 41/83 (49%), Gaps = 10/83 (12%)
Query: 625 GDQTHSKSSEELSLPPPPPPPPPPPPPPPPPP--PPLRALSSSSQAATHQNLGFRAPVKD 682
G HS L PPPPPPPP PPPPPPPPP +R L S+ + R P K
Sbjct: 61 GRDRHSPPGCHLFPPPPPPPPPLPPPPPPPPPDKDDIRLLPSALGVKKRK----RGPKKQ 116
Query: 683 DQPRPLVCESPAER-PRDSLESF 704
+ +P P +R RDS E F
Sbjct: 117 KENKP---GKPRKRKKRDSEEEF 136
Score = 33.5 bits (75), Expect = 0.81
Identities = 20/83 (24%), Positives = 32/83 (38%), Gaps = 12/83 (14%)
Query: 590 SRKTRGVPLSEAGNVKSPKCQNCHGNIPVQ------------VFVPVGDQTHSKSSEELS 637
++K +P+S+ + K + N P + V +Q + S
Sbjct: 233 AKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATP 292
Query: 638 LPPPPPPPPPPPPPPPPPPPPLR 660
+ P PP PPPP PPP+R
Sbjct: 293 IAPSGPPALPPPPAADIQPPPIR 315
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,529,290
Number of Sequences: 37866
Number of extensions: 2378667
Number of successful extensions: 88479
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1070
Number of HSP's successfully gapped in prelim test: 925
Number of HSP's that attempted gapping in prelim test: 37099
Number of HSP's gapped (non-prelim): 21041
length of query: 809
length of database: 18,247,518
effective HSP length: 110
effective length of query: 699
effective length of database: 14,082,258
effective search space: 9843498342
effective search space used: 9843498342
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.