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Search of human proteins with 122891872
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122891872 microcephalin [Homo sapiens]
(835 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122891872 microcephalin [Homo sapiens] 1694 0.0
gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi... 60 1e-08
gi|237681119 breast cancer 1, early onset isoform 2 [Homo sapiens] 47 6e-05
gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens] 47 6e-05
gi|237681121 breast cancer 1, early onset isoform 3 [Homo sapiens] 47 6e-05
gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens] 47 6e-05
gi|188219549 ankyrin repeat domain 32 [Homo sapiens] 45 4e-04
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 43 0.001
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 42 0.002
gi|7662074 zinc finger and BTB domain containing 5 [Homo sapiens] 42 0.003
gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens] 41 0.004
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 41 0.005
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 41 0.005
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 41 0.005
gi|50083281 KIAA1853 protein [Homo sapiens] 39 0.026
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 38 0.034
gi|117676384 splicing factor, arginine/serine-rich 2, interactin... 37 0.058
gi|5031877 lamin B1 [Homo sapiens] 36 0.13
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 36 0.13
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens] 35 0.22
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 35 0.29
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 34 0.49
gi|125656165 THO complex 2 [Homo sapiens] 34 0.64
gi|59891448 rapamycin-insensitive companion of mTOR [Homo sapiens] 33 0.84
gi|54124343 hypothetical protein LOC387680 [Homo sapiens] 33 0.84
gi|154090959 hypothetical protein LOC55747 [Homo sapiens] 33 0.84
gi|21735569 claspin [Homo sapiens] 33 1.1
gi|221139764 PHD and ring finger domains 1 [Homo sapiens] 33 1.1
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 33 1.1
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 33 1.1
>gi|122891872 microcephalin [Homo sapiens]
Length = 835
Score = 1694 bits (4386), Expect = 0.0
Identities = 835/835 (100%), Positives = 835/835 (100%)
Query: 1 MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTW 60
MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTW
Sbjct: 1 MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTW 60
Query: 61 DKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKT 120
DKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKT
Sbjct: 61 DKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKT 120
Query: 121 PENDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRL 180
PENDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRL
Sbjct: 121 PENDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRL 180
Query: 181 QEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCG 240
QEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCG
Sbjct: 181 QEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCG 240
Query: 241 NSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI 300
NSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI
Sbjct: 241 NSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI 300
Query: 301 NLQRNIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVS 360
NLQRNIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVS
Sbjct: 301 NLQRNIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVS 360
Query: 361 HGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDN 420
HGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDN
Sbjct: 361 HGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDN 420
Query: 421 LKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKT 480
LKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKT
Sbjct: 421 LKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKT 480
Query: 481 ISSPRKTGNGEGRATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDD 540
ISSPRKTGNGEGRATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDD
Sbjct: 481 ISSPRKTGNGEGRATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDD 540
Query: 541 DLTPLEGSLEEMKEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIVDCNMETSTEEKE 600
DLTPLEGSLEEMKEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIVDCNMETSTEEKE
Sbjct: 541 DLTPLEGSLEEMKEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIVDCNMETSTEEKE 600
Query: 601 NLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQ 660
NLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQ
Sbjct: 601 NLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQ 660
Query: 661 NVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELG 720
NVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELG
Sbjct: 661 NVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELG 720
Query: 721 HWISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPAMFVSPASSPPVAKLCELVH 780
HWISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPAMFVSPASSPPVAKLCELVH
Sbjct: 721 HWISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPAMFVSPASSPPVAKLCELVH 780
Query: 781 LCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
LCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ
Sbjct: 781 LCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
>gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapiens]
Length = 1522
Score = 59.7 bits (143), Expect = 1e-08
Identities = 156/763 (20%), Positives = 289/763 (37%), Gaps = 123/763 (16%)
Query: 20 GTENYSKTFTTQLVDMGAKVSKTFNKQV---------THVIFKDGYQSTWDKAQKRGVKL 70
G E S TF L +GA V + F ++ TH+I K+ S ++ A+K +
Sbjct: 658 GAEKESLTFLANL--LGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPA 715
Query: 71 VSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKK 130
V++ W+ + G DES F N + SL + + + N T E+
Sbjct: 716 VTIAWLLETARTGKRADESHFLIENSTKEERSL---ETEITNGINLNSDTAEH------- 765
Query: 131 FEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRLQEMKEKRENL 190
P +++ + TP +++N A + + ++
Sbjct: 766 -------------------PGTRLQTHRKTVVTP-LDMNRFQSKAF-RAVVSQHARQVAA 804
Query: 191 SPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCGNSGCGNQERK 250
SP Q +Q+ PS L +S+D L + ++ + S Q+RK
Sbjct: 805 SPAVGQPLQKE---PSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPS---QQKRK 858
Query: 251 LEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEINLQRN----I 306
+ S+V + +L L N SS + L +SPQ + KEE +
Sbjct: 859 PSTPL----SEVIVKNLQLALAN--SSRNAVALS-ASPQLKEAQSEKEEAPKPLHKVVVC 911
Query: 307 AGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSH-GSHS 365
K ++ Q + G++ + YR S T H + RP ++ + K V G H
Sbjct: 912 VSKKLSKKQSELNGIAASLGAD-YRWS--FDETVTHFIYQGRPNDTNREYKSVKERGVHI 968
Query: 366 PPK-------EKCKRKRSTR--RSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYF 416
+ ++CK + + P++ L S + + L LS S+ DD
Sbjct: 969 VSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRL--LSAVSSTKDDEP 1026
Query: 417 SPDNLKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNF 476
P L+E +N+ ++ S+P+ S ++ SK T EM + K+ + +
Sbjct: 1027 DPLILEENDVDNMATNNK-ESAPSNGSGKNDSKGVLTQTLEMREN--FQKQLQEI----M 1079
Query: 477 TAKTISSPRKTGNGEGRATSSCVTSAPE-------------EALRCCRQAGKE------- 516
+A +I P+ R+ + +S P+ EALR RQ +
Sbjct: 1080 SATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQ 1139
Query: 517 ---------DACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMKEAVGLKSTQNKGTT 567
A E + ++ P+ P + + L+ ++ ++++ K +
Sbjct: 1140 NEQIIWDDPTAREERARLASNLQWPSCPTQYSE----LQVDIQNLEDSPFQKPLHDS-EI 1194
Query: 568 SKISNSSEGEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDSCDGF 627
+K + G + P + +ET ++ +P + S+ V +
Sbjct: 1195 AKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKI 1254
Query: 628 KDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETT-THV 686
+ + HEELKK ++S+ +++ +++KL G I + T TH+
Sbjct: 1255 ITIEETHEELKKQ-------YIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHI 1307
Query: 687 LSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFE 729
+ G PLR L +A G WVL ++ GH++ EE +E
Sbjct: 1308 VVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYE 1350
Score = 39.3 bits (90), Expect = 0.015
Identities = 39/160 (24%), Positives = 68/160 (42%), Gaps = 30/160 (18%)
Query: 31 QLVDMGAKVS-KTFNKQVTHVI---FKDGYQSTWDKAQKRGVKLVSVLWVEKCRTAGAHI 86
+L++ G V N+ VTHVI + D + W+K+ R +V W+ +C + G +
Sbjct: 379 RLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRP-HVVGAKWLLECFSKGYML 437
Query: 87 DESLF----------PAANMNEHLSSLIKKKRKCMQPKDF--NFKTPENDKRFQKKFEKM 134
E + P ++ E ++L+KKK KDF + K + D+ ++E
Sbjct: 438 SEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENG 497
Query: 135 AKELQRQKTN-------------LDDDVPILLFESNGSLI 161
+ + KT+ L+D I L E N S +
Sbjct: 498 SSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV 537
>gi|237681119 breast cancer 1, early onset isoform 2 [Homo sapiens]
Length = 1884
Score = 47.4 bits (111), Expect = 6e-05
Identities = 54/230 (23%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 1659 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 1717
Query: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGP 750
RTL LGIA G WV+SY WV S++ ++E FE+ + H GP
Sbjct: 1718 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV-----RGDVVNGRNH--QGP 1770
Query: 751 YRG------TLFADQPAMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGP----- 799
R +F P ++ P +L +V LCG V V +S +G
Sbjct: 1771 KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASV--VKELSSFTLGTGVHPI 1828
Query: 800 --------------YSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
++ + ++ +WVLDS+ ++ + YL+ Q
Sbjct: 1829 VVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ 1878
Score = 32.3 bits (72), Expect = 1.9
Identities = 76/332 (22%), Positives = 129/332 (38%), Gaps = 55/332 (16%)
Query: 264 ISSLVLKANNIHSS--PSFTHLDKSSPQKFLSNLSKEEINLQRNIAGKVVTPDQKQAAGM 321
IS++ L+ N IH+S P L + S + + L E+ + RN++ T Q +
Sbjct: 591 ISNMELELN-IHNSKAPKKNRLRRKSSTRHIHAL---ELVVSRNLSPPNCTELQIDSCSS 646
Query: 322 SQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSTRRSI 381
S+E ++KY P S L+ P + + K S+ P ++ KR S
Sbjct: 647 SEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKK-------SNKPNEQTSKRHDS---DT 696
Query: 382 MPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDNLKERYSENLPPESQLPSSPAQ 441
P L+L + P S ++ +P +E E L E+ S+ A+
Sbjct: 697 FPELKLTNA---------PGSFTKCSNTSELKEFVNPSLPREEKEEKL--ETVKVSNNAE 745
Query: 442 ------LSCRSLSKKERTSIFEMSDFSCV-GKKTRTVDITNFTAKTISSPRKTGNGEGRA 494
LS + + ER+ E S S V G T + + + +S+ K +
Sbjct: 746 DPKDLMLSGERVLQTERS--VESSSISLVPGTDYGTQE--SISLLEVSTLGKAKTEPNKC 801
Query: 495 TSSCVT-SAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMK 553
S C P+ + C + + D GF Y P GH+ + + E S+E +
Sbjct: 802 VSQCAAFENPKGLIHGCSKDNRNDT----EGFKY-------PLGHEVNHS-RETSIEMEE 849
Query: 554 EAVGLKSTQNKGTTSKISN----SSEGEAQSE 581
+ + QN SK + S+ G A+ E
Sbjct: 850 SELDAQYLQNTFKVSKRQSFAPFSNPGNAEEE 881
>gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens]
Length = 759
Score = 47.4 bits (111), Expect = 6e-05
Identities = 54/230 (23%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 534 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 592
Query: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGP 750
RTL LGIA G WV+SY WV S++ ++E FE+ + H GP
Sbjct: 593 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV-----RGDVVNGRNH--QGP 645
Query: 751 YRG------TLFADQPAMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGP----- 799
R +F P ++ P +L +V LCG V V +S +G
Sbjct: 646 KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASV--VKELSSFTLGTGVHPI 703
Query: 800 --------------YSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
++ + ++ +WVLDS+ ++ + YL+ Q
Sbjct: 704 VVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ 753
>gi|237681121 breast cancer 1, early onset isoform 3 [Homo sapiens]
Length = 1816
Score = 47.4 bits (111), Expect = 6e-05
Identities = 54/230 (23%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 1591 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 1649
Query: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGP 750
RTL LGIA G WV+SY WV S++ ++E FE+ + H GP
Sbjct: 1650 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV-----RGDVVNGRNH--QGP 1702
Query: 751 YRG------TLFADQPAMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGP----- 799
R +F P ++ P +L +V LCG V V +S +G
Sbjct: 1703 KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASV--VKELSSFTLGTGVHPI 1760
Query: 800 --------------YSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
++ + ++ +WVLDS+ ++ + YL+ Q
Sbjct: 1761 VVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ 1810
Score = 32.3 bits (72), Expect = 1.9
Identities = 76/332 (22%), Positives = 129/332 (38%), Gaps = 55/332 (16%)
Query: 264 ISSLVLKANNIHSS--PSFTHLDKSSPQKFLSNLSKEEINLQRNIAGKVVTPDQKQAAGM 321
IS++ L+ N IH+S P L + S + + L E+ + RN++ T Q +
Sbjct: 544 ISNMELELN-IHNSKAPKKNRLRRKSSTRHIHAL---ELVVSRNLSPPNCTELQIDSCSS 599
Query: 322 SQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSTRRSI 381
S+E ++KY P S L+ P + + K S+ P ++ KR S
Sbjct: 600 SEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKK-------SNKPNEQTSKRHDS---DT 649
Query: 382 MPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDNLKERYSENLPPESQLPSSPAQ 441
P L+L + P S ++ +P +E E L E+ S+ A+
Sbjct: 650 FPELKLTNA---------PGSFTKCSNTSELKEFVNPSLPREEKEEKL--ETVKVSNNAE 698
Query: 442 ------LSCRSLSKKERTSIFEMSDFSCV-GKKTRTVDITNFTAKTISSPRKTGNGEGRA 494
LS + + ER+ E S S V G T + + + +S+ K +
Sbjct: 699 DPKDLMLSGERVLQTERS--VESSSISLVPGTDYGTQE--SISLLEVSTLGKAKTEPNKC 754
Query: 495 TSSCVT-SAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMK 553
S C P+ + C + + D GF Y P GH+ + + E S+E +
Sbjct: 755 VSQCAAFENPKGLIHGCSKDNRNDT----EGFKY-------PLGHEVNHS-RETSIEMEE 802
Query: 554 EAVGLKSTQNKGTTSKISN----SSEGEAQSE 581
+ + QN SK + S+ G A+ E
Sbjct: 803 SELDAQYLQNTFKVSKRQSFAPFSNPGNAEEE 834
>gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens]
Length = 1863
Score = 47.4 bits (111), Expect = 6e-05
Identities = 54/230 (23%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 1638 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 1696
Query: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGP 750
RTL LGIA G WV+SY WV S++ ++E FE+ + H GP
Sbjct: 1697 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV-----RGDVVNGRNH--QGP 1749
Query: 751 YRG------TLFADQPAMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGP----- 799
R +F P ++ P +L +V LCG V V +S +G
Sbjct: 1750 KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASV--VKELSSFTLGTGVHPI 1807
Query: 800 --------------YSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
++ + ++ +WVLDS+ ++ + YL+ Q
Sbjct: 1808 VVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ 1857
Score = 32.3 bits (72), Expect = 1.9
Identities = 76/332 (22%), Positives = 129/332 (38%), Gaps = 55/332 (16%)
Query: 264 ISSLVLKANNIHSS--PSFTHLDKSSPQKFLSNLSKEEINLQRNIAGKVVTPDQKQAAGM 321
IS++ L+ N IH+S P L + S + + L E+ + RN++ T Q +
Sbjct: 591 ISNMELELN-IHNSKAPKKNRLRRKSSTRHIHAL---ELVVSRNLSPPNCTELQIDSCSS 646
Query: 322 SQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSTRRSI 381
S+E ++KY P S L+ P + + K S+ P ++ KR S
Sbjct: 647 SEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKK-------SNKPNEQTSKRHDS---DT 696
Query: 382 MPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDNLKERYSENLPPESQLPSSPAQ 441
P L+L + P S ++ +P +E E L E+ S+ A+
Sbjct: 697 FPELKLTNA---------PGSFTKCSNTSELKEFVNPSLPREEKEEKL--ETVKVSNNAE 745
Query: 442 ------LSCRSLSKKERTSIFEMSDFSCV-GKKTRTVDITNFTAKTISSPRKTGNGEGRA 494
LS + + ER+ E S S V G T + + + +S+ K +
Sbjct: 746 DPKDLMLSGERVLQTERS--VESSSISLVPGTDYGTQE--SISLLEVSTLGKAKTEPNKC 801
Query: 495 TSSCVT-SAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMK 553
S C P+ + C + + D GF Y P GH+ + + E S+E +
Sbjct: 802 VSQCAAFENPKGLIHGCSKDNRNDT----EGFKY-------PLGHEVNHS-RETSIEMEE 849
Query: 554 EAVGLKSTQNKGTTSKISN----SSEGEAQSE 581
+ + QN SK + S+ G A+ E
Sbjct: 850 SELDAQYLQNTFKVSKRQSFAPFSNPGNAEEE 881
>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
Length = 1058
Score = 44.7 bits (104), Expect = 4e-04
Identities = 20/84 (23%), Positives = 44/84 (52%)
Query: 646 PTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGC 705
P + MT E++ +++++ KL I + + TH+++ + ++ L A G
Sbjct: 6 PKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGK 65
Query: 706 WVLSYDWVLWSLELGHWISEEPFE 729
W+L+ D+++ S + G W+ E +E
Sbjct: 66 WILTKDYIIHSAKSGRWLDETTYE 89
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 3/99 (3%)
Query: 634 HEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVL-SGKPL 692
H + +G+ + L+ + + SE+Q ++ ++ LK + T THV+ G +
Sbjct: 556 HCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYT-EFDSTVTHVVVPGDAV 614
Query: 693 R-TLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFEL 730
+ TL +LGI GCW+L ++WV L EE +E+
Sbjct: 615 QSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEI 653
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 42.4 bits (98), Expect = 0.002
Identities = 56/234 (23%), Positives = 98/234 (41%), Gaps = 23/234 (9%)
Query: 241 NSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI 300
N+ C +R+ GS + + + + + + SS +SPQ+ + E
Sbjct: 1506 NNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQE------RSES 1559
Query: 301 NLQRNIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVS 360
+ + K TP ++++ S + K RLSP S + + +PR++ R
Sbjct: 1560 DSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAA----PRAQ 1615
Query: 361 HGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDN 420
GS S P+ K R+ +PR S + + GP+ E S ESS ++
Sbjct: 1616 SGSDSSPEPKAPAPRA-----LPRRSRSGSSSKGR---GPSPEGSSSTESS-PEHPPKSR 1666
Query: 421 LKERYSENLP-PESQLPSSPAQLSCRS---LSKKERTSIFEMSDFSCVGKKTRT 470
R S + P P+++ + P + S RS L++K R S S S ++RT
Sbjct: 1667 TARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRT 1720
>gi|7662074 zinc finger and BTB domain containing 5 [Homo sapiens]
Length = 677
Score = 41.6 bits (96), Expect = 0.003
Identities = 76/362 (20%), Positives = 133/362 (36%), Gaps = 49/362 (13%)
Query: 315 QKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRS-SSVKRKRVSHGSHSPPKEKCKR 373
Q+Q+A M + ++ LS S+ +P SS R + + P + KR
Sbjct: 134 QEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKR 193
Query: 374 KRSTRRSIMPRLQLCRSEDRLQHVA---GPALEALSCGESSYDDYFSPDNLK-------E 423
K+S RL+ E + V GP+ G S +++FSPD+LK +
Sbjct: 194 KQSAEERARQRLRPSIDESAISDVTPENGPS------GVHSREEFFSPDSLKIVDNPKAD 247
Query: 424 RYSEN-------------LPPESQLPS-------SPAQLSCRSLSKKERTSIF-----EM 458
++N ++Q+PS + AQLS S + + TS E
Sbjct: 248 GMTDNQEDSAIMFDQSFGTQEDAQVPSQSDNSAGNMAQLSMASRATQVETSFDQEAAPEK 307
Query: 459 SDFSCVGKKTRTVDITNFTAKTISSPRKTGNGEGR---ATSSCVTSAPEEALRCCRQAGK 515
S F C + + + S P + + TS S E A K
Sbjct: 308 SSFQCENPEVGLGEKEHMRVVVKSEPLSSPEPQDEVSDVTSQAEGSESVEVEGVVVSAEK 367
Query: 516 EDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMKEAVGLKSTQNKGTTSKISNSSE 575
D PE + S++ + + D + + +LE K + + NK S+ +N +
Sbjct: 368 IDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEH-KSTFSISNFLNK---SRGNNFTA 423
Query: 576 GEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHE 635
+ ++ P DC +E+ + G +G + P H S ++P +
Sbjct: 424 NQNNDDNIPNTTSDCRLESEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPADSHFVRPMQ 483
Query: 636 EL 637
E+
Sbjct: 484 EV 485
>gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens]
Length = 699
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/100 (30%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 534 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 592
Query: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFEL 730
RTL LGIA G WV+SY WV S++ ++E FE+
Sbjct: 593 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV 632
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/176 (26%), Positives = 72/176 (40%), Gaps = 16/176 (9%)
Query: 494 ATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLT-PLEGSLEEM 552
+TSSC S PE + C CPE + F EDP L DDL+ P + +
Sbjct: 461 STSSCEISLPENSNSC---RSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSD 517
Query: 553 KEAVGLKSTQNKGTTSKISNSSE--GEAQSEHEPCF-IVDCNMETSTEEKENLPGGYSGS 609
+VG +S++ TS NS G + S H +V + T++K Y
Sbjct: 518 HRSVGGRSSR---ATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIE----YESR 570
Query: 610 VKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQ 665
+K+ R+ L+ D + +E KK + R +EK+N ++Q
Sbjct: 571 IKSLEQRNLTLETEMMSLHDEL--DQERKKFTMIEIKMRNAERAKEDAEKRNDMLQ 624
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/176 (26%), Positives = 72/176 (40%), Gaps = 16/176 (9%)
Query: 494 ATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLT-PLEGSLEEM 552
+TSSC S PE + C CPE + F EDP L DDL+ P + +
Sbjct: 463 STSSCEISLPENSNSC---RSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSD 519
Query: 553 KEAVGLKSTQNKGTTSKISNSSE--GEAQSEHEPCF-IVDCNMETSTEEKENLPGGYSGS 609
+VG +S++ TS NS G + S H +V + T++K Y
Sbjct: 520 HRSVGGRSSR---ATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIE----YESR 572
Query: 610 VKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQ 665
+K+ R+ L+ D + +E KK + R +EK+N ++Q
Sbjct: 573 IKSLEQRNLTLETEMMSLHDEL--DQERKKFTMIEIKMRNAERAKEDAEKRNDMLQ 626
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/176 (26%), Positives = 72/176 (40%), Gaps = 16/176 (9%)
Query: 494 ATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLT-PLEGSLEEM 552
+TSSC S PE + C CPE + F EDP L DDL+ P + +
Sbjct: 556 STSSCEISLPENSNSC---RSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSD 612
Query: 553 KEAVGLKSTQNKGTTSKISNSSE--GEAQSEHEPCF-IVDCNMETSTEEKENLPGGYSGS 609
+VG +S++ TS NS G + S H +V + T++K Y
Sbjct: 613 HRSVGGRSSR---ATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIE----YESR 665
Query: 610 VKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQ 665
+K+ R+ L+ D + +E KK + R +EK+N ++Q
Sbjct: 666 IKSLEQRNLTLETEMMSLHDEL--DQERKKFTMIEIKMRNAERAKEDAEKRNDMLQ 719
>gi|50083281 KIAA1853 protein [Homo sapiens]
Length = 611
Score = 38.5 bits (88), Expect = 0.026
Identities = 64/285 (22%), Positives = 101/285 (35%), Gaps = 44/285 (15%)
Query: 315 QKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRK 374
+K+ + + Y SP K H R RS S KR+ S S +++ + K
Sbjct: 111 KKKKSTRKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHK 170
Query: 375 RST----RRSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDNLKERYSENL- 429
+ + R+S R C S + + E+ G S + S R S+ L
Sbjct: 171 KQSRSRPRKSHRHRHHRCPSRSQSSESRPSSCESRHRGRSPEEGQKSRRRHSRRCSKTLC 230
Query: 430 --PPESQL---PSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKTISSP 484
PE+Q PS P Q+ + S G T + + KT +SP
Sbjct: 231 KDSPEAQSSRPPSQPLQM---------------LGYLSARGVITGSGSAADLFTKT-ASP 274
Query: 485 RKTGNGEGRA--TSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDL 542
T G + + + +S P R G+E P G L K + +
Sbjct: 275 LTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPSG----------GLSKSRELN- 323
Query: 543 TPLEGSLEEMKEAVGLKSTQNKGT-TSKISNSSEG-EAQSEHEPC 585
G+ + + S QNKG +S +S G E++ PC
Sbjct: 324 ---SGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPC 365
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 38.1 bits (87), Expect = 0.034
Identities = 41/174 (23%), Positives = 81/174 (46%), Gaps = 15/174 (8%)
Query: 672 GFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELS 731
G S+A E + H+++ + RT+ L + RG +LS DW+ S + G ++ + + ++
Sbjct: 1913 GGSLAGSAAEAS-HLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVT 1971
Query: 732 HHFPAAPLCRS-ECHLSAGPYRGTLFADQPAMFVSPASSPPVAKLCELVHLCGGR-VSQV 789
S + LS R L + ++V+P PP ++ E++ CGG + +
Sbjct: 1972 DPEQEKNFGFSLQDALSRARERRLL--EGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSM 2029
Query: 790 PR----QASIVIGPY-----SGKKKATVKYLSEKWVLDSITQHKVCAPENYLLS 834
PR Q ++ P S + + LS +++L + + + PE ++LS
Sbjct: 2030 PRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQE-AKPEAFVLS 2082
>gi|117676384 splicing factor, arginine/serine-rich 2, interacting
protein [Homo sapiens]
Length = 1463
Score = 37.4 bits (85), Expect = 0.058
Identities = 69/353 (19%), Positives = 138/353 (39%), Gaps = 45/353 (12%)
Query: 92 PAANMNEHLSSLIKKKR-------KCMQPKDFNFKTPE--NDKRFQKKFEKMAKELQRQK 142
P ++++E++ S++ +++ + + KDF KT E + + ++ + + RQ
Sbjct: 567 PLSDLSENVESVVNEEKITESSLVEITEHKDFTLKTEELIESPKLESSEGEIIQTVDRQS 626
Query: 143 TNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRLQEMKEKRENLSPTS--SQMIQQ 200
+V +L + T +EI ++ + + +++ NL + + +++
Sbjct: 627 VK-SPEVQLL------GHVETEDVEIIATCDTFGNEDFNNIQDSENNLLKNNLLNTKLEK 679
Query: 201 SHDNPSNSLCEAPLNISRDTLCSDE---YFAGGLHSSFDDLCGNSGCGNQERKLEGSIN- 256
S + + SL E P + ++ +F+ + C + E ++E S+N
Sbjct: 680 SLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMECDSFCSDQNESEVEPSVNA 739
Query: 257 DIKSDVCISSLVLKANNIHSSP------SFTHLDKSSPQKFLSNLSKEEINLQRNIAGKV 310
D+K S NN+ SS SP+ + K R +
Sbjct: 740 DLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPST 799
Query: 311 V------TPDQK---QAAGMSQETFEEKYRL---SPTLSSTKGHLLIHSRPRSSSVKRKR 358
TP +K Q+ +ET +E + SP S +G S+ + R+R
Sbjct: 800 TWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARER 859
Query: 359 VSHGSHSPPKEKCKRKRSTRRSIMPRLQLCRSEDRLQHVAGPALEALSCGESS 411
S SP ++ + R + S+ PR + R R Q P ++ S GE S
Sbjct: 860 RQSQSRSPKRDTTRESRRS-ESLSPRRETSRENKRSQ----PRVKDSSPGEKS 907
>gi|5031877 lamin B1 [Homo sapiens]
Length = 586
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/163 (21%), Positives = 71/163 (43%), Gaps = 16/163 (9%)
Query: 51 IFKDGYQSTWDKAQKRGVKLVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKC 110
++K+ + T+ A+ +L S + +A + ES +++ LS+L K+ R C
Sbjct: 259 LYKEELEQTYH-AKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRAC 317
Query: 111 MQP----KDFNFKTPENDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTI 166
++ +D K +N +R E+ E++ Q +D LL +
Sbjct: 318 LERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLL-----------DV 366
Query: 167 EINSSHHSAMEKRLQEMKEKRENLSPTSSQMIQQSHDNPSNSL 209
++ + ++L E +E+R LSP+ S + S + S S+
Sbjct: 367 KLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSV 409
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo
sapiens]
Length = 1692
Score = 36.2 bits (82), Expect = 0.13
Identities = 36/136 (26%), Positives = 53/136 (38%), Gaps = 12/136 (8%)
Query: 313 PDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCK 372
P+QKQA+ S+ + + +P LS G + S +RKRV S P + +
Sbjct: 254 PEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKS-------ERKRVPKTSAQPVEGAVE 306
Query: 373 RKRSTRRSIMPRLQLCRSED-----RLQHVAGPALEALSCGESSYDDYFSPDNLKERYSE 427
+ R RL+ RS+D + A E E Y + D RY
Sbjct: 307 ERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPV 366
Query: 428 NLPPESQLPSSPAQLS 443
PPE Q A++S
Sbjct: 367 KPPPEEQQMRMHARVS 382
>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
Length = 1198
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 19/100 (19%)
Query: 139 QRQKTNLDDDVPILLFESNGSLIYTPTIE-----INSSHHSAME---KRLQEMKEKRENL 190
Q +++LDDD G +YT TI+ I S H +E K++QE+K + E+
Sbjct: 1009 QPSRSHLDDD---------GMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQ 1059
Query: 191 SPTSSQMIQQSHDNPSNSLCEAPLNISRDTL--CSDEYFA 228
TSS + S+ ++ N+ ++ L CS E F+
Sbjct: 1060 YLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFS 1099
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 35.0 bits (79), Expect = 0.29
Identities = 25/102 (24%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Query: 123 NDKRFQKKFEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRLQE 182
N + +QK + +EL + K ++V L+ + IE ++ H A +L E
Sbjct: 226 NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQ----------IEASAKEHEAEINKLNE 275
Query: 183 MKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISRDT-LCS 223
+KE S + IQ+ ++ +L +A N ++D +CS
Sbjct: 276 LKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICS 317
Score = 31.2 bits (69), Expect = 4.2
Identities = 32/166 (19%), Positives = 65/166 (39%), Gaps = 8/166 (4%)
Query: 94 ANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMAKELQRQKTNLDDDVPILL 153
AN+ + L + + + + F + +N K+ Q++ EK+ + Q L +
Sbjct: 150 ANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATT 209
Query: 154 FESNGSLIYTPT-IEINSSHH-----SAMEKRLQEMKEKRENLSPTSSQM--IQQSHDNP 205
E ++ IE NS H+ S E+ LQ +E + Q+ + H+
Sbjct: 210 DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAE 269
Query: 206 SNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCGNSGCGNQERKL 251
N L E N+ + S++ ++L + NQ+ ++
Sbjct: 270 INKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 34.3 bits (77), Expect = 0.49
Identities = 32/139 (23%), Positives = 57/139 (41%), Gaps = 10/139 (7%)
Query: 81 TAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMAKELQR 140
T + E L A + L +I++K +Q KD + E K K +K+ +
Sbjct: 45 TTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ--EERKAADNKIKKLKLHAKA 102
Query: 141 QKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSA--------MEKRLQEMKEKRENLSP 192
+ T+L+ + + + L P E S H +EK +++EK E +S
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIST 162
Query: 193 TSSQMIQQSHDNPSNSLCE 211
+Q+ Q + P+ S E
Sbjct: 163 LQAQLTQAQAEQPAQSSTE 181
Score = 30.0 bits (66), Expect = 9.3
Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 86 IDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDK--RFQKKFEKMAKELQRQKT 143
+++ L N+ L++ I+ + M N + N++ ++K++ KEL + K
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQ-NSRDHANEELDELKRKYDASLKELAQLKE 2773
Query: 144 N--LDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRLQEMKEKRENLSPTSSQMIQQS 201
L+ + LL E+ S+ T E NS H +EK Q++ K E L SSQ+
Sbjct: 2774 QGLLNRERDALLSETAFSMNST---EENSLSH--LEKLNQQLLSKDEQLLHLSSQLEDSY 2828
Query: 202 HDNPSNSLCEAPLNISRDTLCSD 224
+ S S A L RD L ++
Sbjct: 2829 NQVQSFSKAMASLQNERDHLWNE 2851
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 33.9 bits (76), Expect = 0.64
Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 10/98 (10%)
Query: 103 LIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMAKELQRQKTNLDDDVPILLF----ESNG 158
L K K + M KD + K+ E + +KK EK KE +R +N D +VP L E NG
Sbjct: 1447 LSKSKEREMDKKDLD-KSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENG 1505
Query: 159 SLIYTPTIEINSSHHSAMEKRLQEMKEKRENLSPTSSQ 196
++ + S E K+K +N S +S +
Sbjct: 1506 TMGVS-----KHKSESPCESPYPNEKDKEKNKSKSSGK 1538
>gi|59891448 rapamycin-insensitive companion of mTOR [Homo sapiens]
Length = 1708
Score = 33.5 bits (75), Expect = 0.84
Identities = 49/217 (22%), Positives = 88/217 (40%), Gaps = 26/217 (11%)
Query: 418 PDNLKERYSE--NLPPESQLPSSPAQLSCRSLSKKERTSIFEMSD--FSCVGKKTRTVDI 473
PD++++ +E ++P L S S S+ +S+F + D F T +DI
Sbjct: 1005 PDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDI 1064
Query: 474 TNFTAKTI---SSPRKTGNG-EGRATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSY-- 527
T T S P K N A+S V + +L + + + P+G S
Sbjct: 1065 NEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSES 1124
Query: 528 --------TIEDPALPKGHDDDLTPL---EGSLEEMKEAVGLKSTQNKGTTSKISNSSEG 576
T+ +P++ H DD TP+ + +L+ +G K ++ G+T I G
Sbjct: 1125 KTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSI-----G 1179
Query: 577 EAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNR 613
E + F + + E ++ E+ + S +K R
Sbjct: 1180 ENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIR 1216
>gi|54124343 hypothetical protein LOC387680 [Homo sapiens]
Length = 1341
Score = 33.5 bits (75), Expect = 0.84
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 17/130 (13%)
Query: 572 NSSEGEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRH----DVLDDSCDGF 627
+S EG S+ IVD E EE + +S + +NR T + DD CD F
Sbjct: 205 SSEEGSVGSDRGS--IVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLF 262
Query: 628 KDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVL 687
D K E+++ +P R S + ++ ++KG ++ V E T +
Sbjct: 263 ADSEKEEEDIEDIEENTRPKR--------SRPTSFADELAARIKGDAVG-RVDEEPTTLP 313
Query: 688 SG--KPLRTL 695
SG KP +TL
Sbjct: 314 SGEAKPRKTL 323
>gi|154090959 hypothetical protein LOC55747 [Homo sapiens]
Length = 1253
Score = 33.5 bits (75), Expect = 0.84
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 17/130 (13%)
Query: 572 NSSEGEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRH----DVLDDSCDGF 627
+S EG S+ IVD E EE + +S + +NR T + DD CD F
Sbjct: 117 SSEEGSVGSDRGS--IVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLF 174
Query: 628 KDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVL 687
D K E+++ +P R S + ++ ++KG ++ V E T +
Sbjct: 175 ADSEKEEEDIEDIEENTRPKR--------SRPTSFADELAARIKGDAVG-RVDEEPTTLP 225
Query: 688 SG--KPLRTL 695
SG KP +TL
Sbjct: 226 SGEAKPRKTL 235
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 33.1 bits (74), Expect = 1.1
Identities = 43/171 (25%), Positives = 66/171 (38%), Gaps = 13/171 (7%)
Query: 237 DLCGNSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLS 296
D +SG G+ E S D ++ +S + + S S T +SP+K + S
Sbjct: 25 DSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYD-S 83
Query: 297 KEEINLQRNIAGK----------VVTPDQK-QAAGMSQETFEEKYRLSPTLSSTKGHLLI 345
EE N + AGK V D+ + QE E + + LS G+
Sbjct: 84 AEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTD 143
Query: 346 HSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSTRRSIMPRL-QLCRSEDRLQ 395
+ R SS K G+ K K KR+ M ++ QL + E + Q
Sbjct: 144 FTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQ 194
>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
Length = 1648
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/137 (25%), Positives = 56/137 (40%), Gaps = 11/137 (8%)
Query: 328 EKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRST--RRSIMPRL 385
++ R+S T+ SR RSS V + K K +RS+ R S R
Sbjct: 1005 KRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERA 1064
Query: 386 QLCRSEDRL-QHVAGP--------ALEALSCGESSYDDYFSPDNLKERYSENLPPESQLP 436
+ +++D+ +H GP + S G SSY+ Y S K R + P
Sbjct: 1065 KRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSSSYEHYESRKKKKRRSASRPRGRECSP 1124
Query: 437 SSPAQLSCRSLSKKERT 453
+S + CR ++ER+
Sbjct: 1125 TSSLERLCRHKHQRERS 1141
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 3/73 (4%)
Query: 407 CGESSYDDYFSPDNLKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGK 466
C E + D+F D ER+S+ L + Q + LS +S ++K+ E D +
Sbjct: 278 CAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEK---EKDDSLVEER 334
Query: 467 KTRTVDITNFTAK 479
KT V TN K
Sbjct: 335 KTLVVQDTNADPK 347
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/119 (20%), Positives = 55/119 (46%), Gaps = 9/119 (7%)
Query: 100 LSSLIKKKRKCMQPKDFNFKTPE------NDKRFQK---KFEKMAKELQRQKTNLDDDVP 150
++ L KKK +C Q D +T + N+++ ++ ++E+ K+L ++ ++D
Sbjct: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
Query: 151 ILLFESNGSLIYTPTIEINSSHHSAMEKRLQEMKEKRENLSPTSSQMIQQSHDNPSNSL 209
L + + +E + L++ KEK +L ++Q + H+N ++ L
Sbjct: 1340 TLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVL 1398
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,198,684
Number of Sequences: 37866
Number of extensions: 1717834
Number of successful extensions: 4678
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 4604
Number of HSP's gapped (non-prelim): 167
length of query: 835
length of database: 18,247,518
effective HSP length: 111
effective length of query: 724
effective length of database: 14,044,392
effective search space: 10168139808
effective search space used: 10168139808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.