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Search of human proteins with 29294617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 992 0.0
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 855 0.0
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 345 7e-95
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 345 7e-95
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 258 8e-69
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 232 6e-61
gi|37577159 calcium-sensing receptor [Homo sapiens] 219 4e-57
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 180 3e-45
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 132 5e-31
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 128 1e-29
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 128 1e-29
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 122 7e-28
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 121 1e-27
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 119 5e-27
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 117 2e-26
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 117 2e-26
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 112 1e-24
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 112 1e-24
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 105 7e-23
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 105 7e-23
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 55 1e-07
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 1e-07
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 1e-07
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 53 5e-07
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 45 1e-04
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 45 1e-04
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 45 1e-04
gi|134152694 guanylate cyclase 2F [Homo sapiens] 40 0.004
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 38 0.023
gi|169204182 PREDICTED: hypothetical protein [Homo sapiens] 36 0.088
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 992 bits (2565), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
Query: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA
Sbjct: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
Query: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS
Sbjct: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
Query: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS
Sbjct: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
Query: 421 TSTDASLVGKKSGHLREARPASRALWCFWLCVSTPLGCCWQLTRCCCCCCLGLLACLPGT 480
TSTDASLVGKKSGHLREARPASRALWCFWLCVSTPLGCCWQLTRCCCCCCLGLLACLPGT
Sbjct: 421 TSTDASLVGKKSGHLREARPASRALWCFWLCVSTPLGCCWQLTRCCCCCCLGLLACLPGT 480
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 855 bits (2209), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
Query: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA
Sbjct: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
Query: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS
Sbjct: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
Query: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS
Sbjct: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
Length = 324
Score = 345 bits (884), Expect = 7e-95
Identities = 166/167 (99%), Positives = 167/167 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMI 167
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPM+
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 345 bits (884), Expect = 7e-95
Identities = 166/167 (99%), Positives = 167/167 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMI 167
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPM+
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 258 bits (659), Expect = 8e-69
Identities = 155/399 (38%), Positives = 216/399 (54%), Gaps = 14/399 (3%)
Query: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
Query: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHE-DNLLPIQEDYSNYISRVVAVIGPDN 143
Query: 149 TNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGW 208
+ T A LS FL+P I+Y+A S+ L K ++P+ LRT P+ + +E MV L+ F W
Sbjct: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
Query: 209 TWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPF------SAQVGDERMQCLMRH 262
WI ++ SSD YG+ Q L + + ICIAF++ +P +R+ ++
Sbjct: 204 NWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDK 263
Query: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVL 322
L Q+ A VVVVFS FF V+ N TG VW+ASE+WA+ + + ++ +G L
Sbjct: 264 LQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFL 323
Query: 323 GVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWC-SSNQLCRECQAFMAHTMPKLKAF 381
G+ IQ +PG F E +A P P + S + NQ C C L+
Sbjct: 324 GITIQSVPIPGFSEFREWGPQA---GPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLS 380
Query: 382 SMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
Y+ Y AVYAVAH LH LLGC C++ VYPWQ
Sbjct: 381 GERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQ 419
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 232 bits (591), Expect = 6e-61
Identities = 149/414 (35%), Positives = 217/414 (52%), Gaps = 36/414 (8%)
Query: 29 SPDFTLPGDYLLAGLFPL---HSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEE 85
S + GDY+L GLFPL L+ R RP +C R F+ +G AM++ VEE
Sbjct: 26 SQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTR---FSSNGLLWALAMKMAVEE 82
Query: 86 INNSTALLPNITLGYQLYDVCSDSA-NVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVI 144
INN + LLP + LGY L+D CS+ + +L L+ G I + Y P VLAVI
Sbjct: 83 INNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVI 142
Query: 145 GPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQ 204
GP S+ A T S FL+P +SY AS E LS + +PSF RT+P+D+ Q+ LLQ
Sbjct: 143 GPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQ 202
Query: 205 KFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM---QCLMR 261
+FGW W++ +GS D+YG+ G+ A +GICIA + ++P + D R+ Q ++
Sbjct: 203 EFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPL-PRADDSRLGKVQDVLH 261
Query: 262 HLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMV 321
+ Q+ VV++F+S A F + + L+ KVWVASEAW S + G+PG+ ++G V
Sbjct: 262 QVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTV 321
Query: 322 LGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS-------------NQLCRECQ 368
LG +Q+ A L F + A P ++CS+ Q C +C
Sbjct: 322 LGF-LQRGA--QLHEFPQYVKTHLALATDP----AFCSALGEREQGLEEDVVGQRCPQCD 374
Query: 369 AFMAHTMPKLKA-FSMSSAYNAYRAVYAVAHGLHQLLGC-ASGACSRGRVYPWQ 420
T+ + A + ++ Y AVY+VA LH L C ASG ++ V PWQ
Sbjct: 375 CI---TLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQ 425
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 219 bits (558), Expect = 4e-57
Identities = 140/443 (31%), Positives = 214/443 (48%), Gaps = 56/443 (12%)
Query: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
Query: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
Query: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQ 181
I+ + + P+ +AV+G + + A LL F +P +SYA+SS LS K Q
Sbjct: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179
Query: 182 YPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAF 241
+ SFLRTIPND++Q M +++ F W W+ + + DDYG+ G++ +A + ICI F
Sbjct: 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF 239
Query: 242 KDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASE 301
+++ S +E +Q ++ + + A V+VVFSS + +V N+TGK+W+ASE
Sbjct: 240 SELI--SQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
Query: 302 AWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAF-------------------EEAY- 341
AWA S I +G +G A++ +PG + F EE +
Sbjct: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
Query: 342 --ARADKKAPRPC-------------HKGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSA 386
+ K P P S + LC + + P + + +
Sbjct: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
Query: 387 YNAYRAVYAVAHGLHQLLGCASG 409
YN Y AVY++AH L + C G
Sbjct: 418 YNVYLAVYSIAHALQDIYTCLPG 440
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 180 bits (456), Expect = 3e-45
Identities = 105/323 (32%), Positives = 172/323 (53%), Gaps = 12/323 (3%)
Query: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
C + + T PG ++ GLF +H L P F + AM
Sbjct: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
Query: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
Query: 140 VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
V AVIG + + +L+ L+P + Y +++E LS K ++PSFLRT+P+D +Q++ M
Sbjct: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199
Query: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ-- 257
L+QK GW WI ++ + DDYG+L + QA +CIAFK+++P A + D ++
Sbjct: 200 AHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP--AFLSDNTIEVR 257
Query: 258 ---CLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPG 314
L + + +A V+VVF + F + N+ K+W+AS+ W+ + IT +P
Sbjct: 258 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASDNWSTATKITTIPN 316
Query: 315 IQRIGMVLGVAIQKRAVPGLKAF 337
+++IG V+G A ++ + +F
Sbjct: 317 VKKIGKVVGFAFRRGNISSFHSF 339
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 132 bits (333), Expect = 5e-31
Identities = 118/393 (30%), Positives = 175/393 (44%), Gaps = 46/393 (11%)
Query: 33 TLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCS-FNEH-GYHLFQAMRLGVEEINNST 90
TL GD +L GLFP+H + P C NEH G +AM ++ IN
Sbjct: 27 TLEGDLVLGGLFPVHQ-----KGGPA-----EDCGPVNEHRGIQRLEAMLFALDRINRDP 76
Query: 91 ALLPNITLGYQLYDVCSDSAN--------VYATLRVLSLPGQHHIELQGDLLHY--SPTV 140
LLP + LG + D CS + V A+L G HI G + +PT
Sbjct: 77 HLLPGVRLGAHILDSCSKDTHALEQALDFVRASLS-RGADGSRHICPDGSYATHGDAPTA 135
Query: 141 LA-VIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
+ VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D +Q + M
Sbjct: 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM 195
Query: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCL 259
+L+ F WT++S V S DYG+ G++A E +A + IC+A + + + +
Sbjct: 196 AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSE--KVGRAMSRAAFEGV 253
Query: 260 MRHLAQ-AGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAW-ALSRHITGVPGIQR 317
+R L Q A V V+F+ + AR + N WVAS+ W AL + G G
Sbjct: 254 VRALLQKPSARVAVLFTRSEDARELLAASQRLN-ASFTWVASDGWGALESVVAGSEGAAE 312
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARAD--KKAPRPCHKGSW-----CSSNQLCRECQAF 370
+ + +A + F + D + P + W CS Q R+C A
Sbjct: 313 GAITIELASYP-----ISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--RDCAAH 365
Query: 371 MAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403
+P + + N AVYA+AH LH +
Sbjct: 366 SLRAVPFEQESKIMFVVN---AVYAMAHALHNM 395
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 128 bits (321), Expect = 1e-29
Identities = 110/406 (27%), Positives = 184/406 (45%), Gaps = 58/406 (14%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+PGD ++ LF +H H+P V + +R C ++G +AM +E IN+
Sbjct: 31 MPGDIIIGALFSVH-------HQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDP 83
Query: 91 ALLPNITLGYQLYDVCSDSANVYAT----LRVLSLPGQHH------IELQGDLLHYSPTV 140
LLPNITLG ++ D C SA +R + + ++ +
Sbjct: 84 TLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPI 143
Query: 141 LAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMV 200
+ VIGP S++ A LL F +P I+Y+A+S LS K + F+R +P+D Q MV
Sbjct: 144 VGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMV 203
Query: 201 LLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA--FKDIMPFSAQVGDERMQC 258
+++++ WT++S V + +YG+ G++A ++ + +GICIA +K Q D+ ++
Sbjct: 204 DIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKK 263
Query: 259 LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITGVPGIQR 317
L HL + A VV F R ++ L G+ + + S+ WA +T G QR
Sbjct: 264 LTSHLPK--ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVT--DGYQR 319
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS----------------- 360
V G+ I+ ++ P +K F++ Y K P H+ W
Sbjct: 320 -EAVGGITIKLQS-PDVKWFDDYYL---KLRPETNHRNPWFQEFWQHRFQCRLEGFPQEN 374
Query: 361 ---NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403
N+ C H + K M N A+Y++A+GLH +
Sbjct: 375 SKYNKTCNSSLTLKTHHVQDSK---MGFVIN---AIYSMAYGLHNM 414
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 128 bits (321), Expect = 1e-29
Identities = 110/406 (27%), Positives = 184/406 (45%), Gaps = 58/406 (14%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+PGD ++ LF +H H+P V + +R C ++G +AM +E IN+
Sbjct: 31 MPGDIIIGALFSVH-------HQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDP 83
Query: 91 ALLPNITLGYQLYDVCSDSANVYAT----LRVLSLPGQHH------IELQGDLLHYSPTV 140
LLPNITLG ++ D C SA +R + + ++ +
Sbjct: 84 TLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPI 143
Query: 141 LAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMV 200
+ VIGP S++ A LL F +P I+Y+A+S LS K + F+R +P+D Q MV
Sbjct: 144 VGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMV 203
Query: 201 LLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA--FKDIMPFSAQVGDERMQC 258
+++++ WT++S V + +YG+ G++A ++ + +GICIA +K Q D+ ++
Sbjct: 204 DIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKK 263
Query: 259 LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITGVPGIQR 317
L HL + A VV F R ++ L G+ + + S+ WA +T G QR
Sbjct: 264 LTSHLPK--ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVT--DGYQR 319
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS----------------- 360
V G+ I+ ++ P +K F++ Y K P H+ W
Sbjct: 320 -EAVGGITIKLQS-PDVKWFDDYYL---KLRPETNHRNPWFQEFWQHRFQCRLEGFPQEN 374
Query: 361 ---NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403
N+ C H + K M N A+Y++A+GLH +
Sbjct: 375 SKYNKTCNSSLTLKTHHVQDSK---MGFVIN---AIYSMAYGLHNM 414
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 122 bits (306), Expect = 7e-28
Identities = 86/282 (30%), Positives = 138/282 (48%), Gaps = 24/282 (8%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93
+ GD L GLFP+H + + E+ E G H +AM ++ INN LL
Sbjct: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96
Query: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGD----------LLHYSPTVLAV 143
PNITLG ++ D CS + +A + L+ Q IE G ++ V+ V
Sbjct: 97 PNITLGARILDTCS--RDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153
Query: 144 IGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLL 203
IG ++ + A +L F +P ISYA+++ LS +Y F R +P+D YQ + MV ++
Sbjct: 154 IGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIV 213
Query: 204 QKFGWTWISLVGSSDDYGQLGVQA-LENQATGQGICIAFKDIMPFSAQVGDERMQCLMRH 262
+ W ++S V S YG+ GV+A ++ G+CIA +P + G E + + R
Sbjct: 214 RALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAG-EFDKIIRRL 272
Query: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAW 303
L + A V++F++ R E+ N TG W+ S++W
Sbjct: 273 LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSW 314
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 121 bits (304), Expect = 1e-27
Identities = 110/403 (27%), Positives = 169/403 (41%), Gaps = 57/403 (14%)
Query: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNE-HGYHLFQAMRLGVEEINNS 89
+ + GD +L GLFP++ + T + NE G +AM ++EIN
Sbjct: 32 EIKIEGDLVLGGLFPINE---------KGTGTEECGRINEDRGIQRLEAMLFAIDEINKD 82
Query: 90 TALLPNITLGYQLYDVCSDSANVYATLRVLSL----------------PGQHHIELQGDL 133
LLP + LG + D CS + YA + L G + I+ L
Sbjct: 83 DYLLPGVKLGVHILDTCS--RDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPL 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
L + VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D
Sbjct: 141 L-----IAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF 195
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGD 253
YQ + M +L+ F WT++S V S DYG+ G++A E +A + ICIA + + S +
Sbjct: 196 YQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRS-NIRK 254
Query: 254 ERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVP 313
+ L + A VVV+F +R + N WVAS+ W I +
Sbjct: 255 SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESI--IK 311
Query: 314 GIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSW----------CS---S 360
G + + G + A ++ F+ + + P H+ W CS
Sbjct: 312 GSEHV--AYGAITLELASQPVRQFDRYFQSLN---PYNNHRNPWFRDFWEQKFQCSLQNK 366
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403
R C +A + S AVYA+AH LH++
Sbjct: 367 RNHRRVCDKHLAIDSSNYE--QESKIMFVVNAVYAMAHALHKM 407
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 119 bits (299), Expect = 5e-27
Identities = 90/312 (28%), Positives = 146/312 (46%), Gaps = 33/312 (10%)
Query: 11 LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68
L L+ W ++ L G L GLFP+H+ R+C
Sbjct: 12 LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
Query: 69 NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128
E G H +AM ++ +N LLP + LG +L D CS + YA + LS Q I
Sbjct: 62 KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS--RDTYALEQALSFV-QALIR 118
Query: 129 LQGD-------------LLHYSPT--VLAVIGPDSTNRAATTAALLSPFLVPMISYAASS 173
+GD L +P V+AV+G +++ + A +L F +P ISYA+++
Sbjct: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTA 178
Query: 174 ETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQA-LENQA 232
LS +Y F R +P D YQ + MV +++ GW ++S + S +YG+ GV+A ++
Sbjct: 179 PELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISR 238
Query: 233 TGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNL 292
G+CIA +P + G E + + R + A +++F++ R E+ NL
Sbjct: 239 EAGGVCIAQSIKIPREPKPG-EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANL 297
Query: 293 TGK-VWVASEAW 303
TG +WV S++W
Sbjct: 298 TGHFLWVGSDSW 309
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 117 bits (293), Expect = 2e-26
Identities = 87/292 (29%), Positives = 141/292 (48%), Gaps = 24/292 (8%)
Query: 24 HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83
HS E + + GD +L GLFP+H+ + E+ E G H +AM +
Sbjct: 32 HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
Query: 84 EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133
++IN LL NITLG ++ D CS + YA + L+ Q IE GD +
Sbjct: 84 DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
+ VIG +++ + A +L F +P ISYA+++ LS +Y F R +P D
Sbjct: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252
YQ + MV ++ GW ++S + S +YG+ GV+A + G+CIA +P + G
Sbjct: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
Query: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAW 303
E + + R L A V++F++ R E+ N +G +W+ S++W
Sbjct: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 117 bits (293), Expect = 2e-26
Identities = 87/292 (29%), Positives = 141/292 (48%), Gaps = 24/292 (8%)
Query: 24 HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83
HS E + + GD +L GLFP+H+ + E+ E G H +AM +
Sbjct: 32 HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
Query: 84 EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133
++IN LL NITLG ++ D CS + YA + L+ Q IE GD +
Sbjct: 84 DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
+ VIG +++ + A +L F +P ISYA+++ LS +Y F R +P D
Sbjct: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252
YQ + MV ++ GW ++S + S +YG+ GV+A + G+CIA +P + G
Sbjct: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
Query: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAW 303
E + + R L A V++F++ R E+ N +G +W+ S++W
Sbjct: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 112 bits (279), Expect = 1e-24
Identities = 105/401 (26%), Positives = 179/401 (44%), Gaps = 45/401 (11%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
Query: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
Query: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
Query: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
Query: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGLHQL 403
+ K S Y A+YA+AHGL +
Sbjct: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNM 427
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 112 bits (279), Expect = 1e-24
Identities = 105/401 (26%), Positives = 179/401 (44%), Gaps = 45/401 (11%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
Query: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
Query: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
Query: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
Query: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGLHQL 403
+ K S Y A+YA+AHGL +
Sbjct: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNM 427
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 105 bits (263), Expect = 7e-23
Identities = 82/307 (26%), Positives = 141/307 (45%), Gaps = 30/307 (9%)
Query: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71
++ C A A E + + GD L GLFP+H+ P C E+
Sbjct: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129
Query: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179
D T V+ VIG ++ + A +L F +P ISYA+++ LS
Sbjct: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189
Query: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQAL-ENQATGQGIC 238
R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ + G+C
Sbjct: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249
Query: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296
IA +P + +++ L + VV+F++ + + + + G +
Sbjct: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309
Query: 297 WVASEAW 303
WV S++W
Sbjct: 310 WVGSDSW 316
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 105 bits (263), Expect = 7e-23
Identities = 82/307 (26%), Positives = 141/307 (45%), Gaps = 30/307 (9%)
Query: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71
++ C A A E + + GD L GLFP+H+ P C E+
Sbjct: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129
Query: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179
D T V+ VIG ++ + A +L F +P ISYA+++ LS
Sbjct: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189
Query: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQAL-ENQATGQGIC 238
R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ + G+C
Sbjct: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249
Query: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296
IA +P + +++ L + VV+F++ + + + + G +
Sbjct: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309
Query: 297 WVASEAW 303
WV S++W
Sbjct: 310 WVGSDSW 316
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 129 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 174
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 175 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 232
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 233 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 288
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 289 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 327
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 74 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 119
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 120 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 177
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 178 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 233
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 234 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 272
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 191 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 236
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 237 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 294
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 295 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 350
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 351 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 389
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 53.1 bits (126), Expect = 5e-07
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 15/137 (10%)
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G + A+ L +E+I N + L P L +LYD D+A ++
Sbjct: 74 GRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAK--------------GLKAFY 118
Query: 132 DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPN 191
D + Y P L V G + + A L + + +S+AA++ L+ K++YP F RT+P+
Sbjct: 119 DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 178
Query: 192 DKYQVETMVLLLQKFGW 208
D ++ LL+ + W
Sbjct: 179 DNAVNPAILKLLKHYQW 195
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 45.1 bits (105), Expect = 1e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 45.1 bits (105), Expect = 1e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 45.1 bits (105), Expect = 1e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/143 (25%), Positives = 59/143 (41%), Gaps = 22/143 (15%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQL-YDVCSDSANVYATLRVLSLPGQHHIELQGDLLHY 136
A RL +E IN P+ L Y Y + ++ T R LS HH G
Sbjct: 75 AARLAIERINRD----PSFDLSYSFEYVILNEDCQ---TSRALSSFISHHQMASG----- 122
Query: 137 SPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
IGP + + L + + + S+A + L K YP+F RT+P+ +
Sbjct: 123 ------FIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPS---PI 173
Query: 197 ETMVLLLQKFGWTWISLVGSSDD 219
+V +++ F W ++ S +D
Sbjct: 174 RVLVTVMKYFQWAHAGVISSDED 196
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 37.7 bits (86), Expect = 0.023
Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 4/138 (2%)
Query: 164 VPMISYAASSET-LSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQ 222
VP++S + S L+ K +FL+ + + Q++ + +L+++ W+ +++ S
Sbjct: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHA 176
Query: 223 LGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARV 282
L ++ + A + D++ G R + R L Q A V V + SR+ A V
Sbjct: 177 LFLEGVRAVADASHVSWRLLDVVTLELGPGGPRAR-TQRLLRQLDAPVFVAYCSREEAEV 235
Query: 283 FFESVVLTNLT--GKVWV 298
F L G VW+
Sbjct: 236 LFAEAAQAGLVGPGHVWL 253
>gi|169204182 PREDICTED: hypothetical protein [Homo sapiens]
Length = 220
Score = 35.8 bits (81), Expect = 0.088
Identities = 12/23 (52%), Positives = 13/23 (56%)
Query: 457 GCCWQLTRCCCCCCLGLLACLPG 479
GCC CCCCCC +CL G
Sbjct: 154 GCCCCCCCCCCCCCCWCCSCLGG 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.135 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,154,779
Number of Sequences: 37866
Number of extensions: 768510
Number of successful extensions: 2563
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2419
Number of HSP's gapped (non-prelim): 80
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.