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Search of human proteins with 28559069
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28559069 DNA cytosine methyltransferase 3 alpha isoform a
[Homo sapiens]
(912 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12751473 DNA cytosine methyltransferase 3 alpha isoform a [Ho... 1905 0.0
gi|28559069 DNA cytosine methyltransferase 3 alpha isoform a [Ho... 1905 0.0
gi|77176455 DNA cytosine methyltransferase 3 alpha isoform b [Ho... 1471 0.0
gi|28559065 DNA cytosine-5 methyltransferase 3 beta isoform 6 [H... 830 0.0
gi|28559061 DNA cytosine-5 methyltransferase 3 beta isoform 2 [H... 830 0.0
gi|5901940 DNA cytosine-5 methyltransferase 3 beta isoform 1 [Ho... 825 0.0
gi|28559063 DNA cytosine-5 methyltransferase 3 beta isoform 3 [H... 650 0.0
gi|28559071 DNA cytosine methyltransferase 3 alpha isoform c [Ho... 308 2e-83
gi|28872780 cytosine-5-methyltransferase 3-like protein isoform ... 253 6e-67
gi|28872778 cytosine-5-methyltransferase 3-like protein isoform ... 253 7e-67
gi|148839376 PWWP domain containing 2 isoform 1 [Homo sapiens] 66 2e-10
gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens] 60 1e-08
gi|51873049 hypothetical protein LOC8603 [Homo sapiens] 56 1e-07
gi|38176300 nestin [Homo sapiens] 54 7e-07
gi|157738619 smoothelin-like 1 [Homo sapiens] 51 4e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 49 2e-05
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 48 4e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 48 5e-05
gi|33286446 opioid growth factor receptor [Homo sapiens] 46 1e-04
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 46 2e-04
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 45 2e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 45 3e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 45 3e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 45 3e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 45 3e-04
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 45 3e-04
gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [H... 44 5e-04
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 44 7e-04
gi|239756562 PREDICTED: hypothetical protein [Homo sapiens] 44 7e-04
gi|11560152 zinc finger protein 335 [Homo sapiens] 44 7e-04
>gi|12751473 DNA cytosine methyltransferase 3 alpha isoform a [Homo
sapiens]
Length = 912
Score = 1905 bits (4935), Expect = 0.0
Identities = 912/912 (100%), Positives = 912/912 (100%)
Query: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
Sbjct: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
Query: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
Sbjct: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
Query: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL 180
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
Sbjct: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL 180
Query: 181 RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE 240
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
Sbjct: 181 RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE 240
Query: 241 EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL 300
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
Sbjct: 241 EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL 300
Query: 301 RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN 360
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
Sbjct: 301 RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN 360
Query: 361 KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK 420
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
Sbjct: 361 KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK 420
Query: 421 GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV 480
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
Sbjct: 421 GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV 480
Query: 481 YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC 540
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
Sbjct: 481 YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC 540
Query: 541 CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED 600
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
Sbjct: 541 CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED 600
Query: 601 WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY 660
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
Sbjct: 601 WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY 660
Query: 661 IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR 720
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
Sbjct: 661 IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR 720
Query: 721 KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI 780
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
Sbjct: 721 KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI 780
Query: 781 DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI 840
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
Sbjct: 781 DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI 840
Query: 841 KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH 900
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
Sbjct: 841 KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH 900
Query: 901 LFAPLKEYFACV 912
LFAPLKEYFACV
Sbjct: 901 LFAPLKEYFACV 912
>gi|28559069 DNA cytosine methyltransferase 3 alpha isoform a [Homo
sapiens]
Length = 912
Score = 1905 bits (4935), Expect = 0.0
Identities = 912/912 (100%), Positives = 912/912 (100%)
Query: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
Sbjct: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
Query: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
Sbjct: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
Query: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL 180
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
Sbjct: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL 180
Query: 181 RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE 240
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
Sbjct: 181 RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE 240
Query: 241 EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL 300
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
Sbjct: 241 EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL 300
Query: 301 RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN 360
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
Sbjct: 301 RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN 360
Query: 361 KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK 420
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
Sbjct: 361 KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK 420
Query: 421 GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV 480
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
Sbjct: 421 GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV 480
Query: 481 YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC 540
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
Sbjct: 481 YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC 540
Query: 541 CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED 600
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
Sbjct: 541 CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED 600
Query: 601 WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY 660
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
Sbjct: 601 WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY 660
Query: 661 IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR 720
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
Sbjct: 661 IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR 720
Query: 721 KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI 780
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
Sbjct: 721 KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI 780
Query: 781 DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI 840
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
Sbjct: 781 DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI 840
Query: 841 KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH 900
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
Sbjct: 841 KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH 900
Query: 901 LFAPLKEYFACV 912
LFAPLKEYFACV
Sbjct: 901 LFAPLKEYFACV 912
>gi|77176455 DNA cytosine methyltransferase 3 alpha isoform b [Homo
sapiens]
Length = 723
Score = 1471 bits (3809), Expect = 0.0
Identities = 699/699 (100%), Positives = 699/699 (100%)
Query: 214 AEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKN 273
AEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKN
Sbjct: 25 AEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKN 84
Query: 274 ATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGD 333
ATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGD
Sbjct: 85 ATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGD 144
Query: 334 GKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDES 393
GKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDES
Sbjct: 145 GKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDES 204
Query: 394 DTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPP 453
DTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPP
Sbjct: 205 DTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPP 264
Query: 454 AKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGM 513
AKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGM
Sbjct: 265 AKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGM 324
Query: 514 CQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ 573
CQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ
Sbjct: 325 CQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ 384
Query: 574 AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKP 633
AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKP
Sbjct: 385 AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKP 444
Query: 634 IRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQK 693
IRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQK
Sbjct: 445 IRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQK 504
Query: 694 HIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFW 753
HIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFW
Sbjct: 505 HIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFW 564
Query: 754 LFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKL 813
LFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKL
Sbjct: 565 LFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKL 624
Query: 814 ELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVH 873
ELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVH
Sbjct: 625 ELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVH 684
Query: 874 YTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV 912
YTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Sbjct: 685 YTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV 723
>gi|28559065 DNA cytosine-5 methyltransferase 3 beta isoform 6 [Homo
sapiens]
Length = 845
Score = 830 bits (2145), Expect = 0.0
Identities = 395/646 (61%), Positives = 486/646 (75%), Gaps = 12/646 (1%)
Query: 266 GSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT 325
G ++ A D EY+DG+ FGIG+LVWGK++GFSWWP +VSW T + +A G
Sbjct: 211 GMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGM 270
Query: 326 RWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFP 385
RWV WFGDGKFS V +KL+ L F F+ AT+NK YRKA+Y L+ A RAGK FP
Sbjct: 271 RWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP 330
Query: 386 VCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEA 445
S ++E Q KPM+EWA GGF+P+G +GL+P + P + +
Sbjct: 331 -------SSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQ--PENKTRRRTADDSAT 381
Query: 446 AAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLE 505
+ Y P P K K + E +++RE++ +V ++ED C+SCG N
Sbjct: 382 SDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGRKNPVSF 438
Query: 506 HPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDL 565
HPLF GG+CQ C++ FLE Y YDDDGYQSYCT+CC GRE+L+C N +CCRCFCVEC+++
Sbjct: 439 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV 498
Query: 566 LVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPP 625
LVG G A A ++PW+CYMC + +G+LRRR+DW RLQ FF ++ E++ PK+YP
Sbjct: 499 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPA 558
Query: 626 VPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVG 685
+PA +R+PIRVLSLFDGIATG LVLK+LGI+V +Y+ASEVCE+SI VG V+H+G I YV
Sbjct: 559 IPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVN 618
Query: 686 DVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKE 745
DVR++T+K+I+EWGPFDLVIGGSPCNDLS VNPARKGLYEGTGRLFFEFY LL+ +RPKE
Sbjct: 619 DVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKE 678
Query: 746 GDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPL 805
GDDRPFFW+FENVVAM V DKRDISRFLE NPVMIDA +VSAAHRARYFWGNLPGMNRP+
Sbjct: 679 GDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPV 738
Query: 806 ASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEME 865
++ NDKLELQ+CLE+ RIAK KV+TITT+SNSIKQGK+Q FPV MN KED+LWCTE+E
Sbjct: 739 IASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELE 798
Query: 866 RVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFAC 911
R+FGFPVHYTDVSNM R ARQ+LLGRSWSVPVIRHLFAPLK+YFAC
Sbjct: 799 RIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFAC 844
>gi|28559061 DNA cytosine-5 methyltransferase 3 beta isoform 2 [Homo
sapiens]
Length = 833
Score = 830 bits (2145), Expect = 0.0
Identities = 395/646 (61%), Positives = 486/646 (75%), Gaps = 12/646 (1%)
Query: 266 GSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT 325
G ++ A D EY+DG+ FGIG+LVWGK++GFSWWP +VSW T + +A G
Sbjct: 199 GMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGM 258
Query: 326 RWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFP 385
RWV WFGDGKFS V +KL+ L F F+ AT+NK YRKA+Y L+ A RAGK FP
Sbjct: 259 RWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP 318
Query: 386 VCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEA 445
S ++E Q KPM+EWA GGF+P+G +GL+P + P + +
Sbjct: 319 -------SSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQ--PENKTRRRTADDSAT 369
Query: 446 AAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLE 505
+ Y P P K K + E +++RE++ +V ++ED C+SCG N
Sbjct: 370 SDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGRKNPVSF 426
Query: 506 HPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDL 565
HPLF GG+CQ C++ FLE Y YDDDGYQSYCT+CC GRE+L+C N +CCRCFCVEC+++
Sbjct: 427 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV 486
Query: 566 LVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPP 625
LVG G A A ++PW+CYMC + +G+LRRR+DW RLQ FF ++ E++ PK+YP
Sbjct: 487 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPA 546
Query: 626 VPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVG 685
+PA +R+PIRVLSLFDGIATG LVLK+LGI+V +Y+ASEVCE+SI VG V+H+G I YV
Sbjct: 547 IPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVN 606
Query: 686 DVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKE 745
DVR++T+K+I+EWGPFDLVIGGSPCNDLS VNPARKGLYEGTGRLFFEFY LL+ +RPKE
Sbjct: 607 DVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKE 666
Query: 746 GDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPL 805
GDDRPFFW+FENVVAM V DKRDISRFLE NPVMIDA +VSAAHRARYFWGNLPGMNRP+
Sbjct: 667 GDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPV 726
Query: 806 ASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEME 865
++ NDKLELQ+CLE+ RIAK KV+TITT+SNSIKQGK+Q FPV MN KED+LWCTE+E
Sbjct: 727 IASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELE 786
Query: 866 RVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFAC 911
R+FGFPVHYTDVSNM R ARQ+LLGRSWSVPVIRHLFAPLK+YFAC
Sbjct: 787 RIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFAC 832
>gi|5901940 DNA cytosine-5 methyltransferase 3 beta isoform 1 [Homo
sapiens]
Length = 853
Score = 825 bits (2131), Expect = 0.0
Identities = 397/664 (59%), Positives = 487/664 (73%), Gaps = 28/664 (4%)
Query: 266 GSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT 325
G ++ A D EY+DG+ FGIG+LVWGK++GFSWWP +VSW T + +A G
Sbjct: 199 GMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGM 258
Query: 326 RWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFP 385
RWV WFGDGKFS V +KL+ L F F+ AT+NK YRKA+Y L+ A RAGK FP
Sbjct: 259 RWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP 318
Query: 386 VCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEE-----------------E 428
S ++E Q KPM+EWA GGF+P+G +GL+P E
Sbjct: 319 -------SSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLE 371
Query: 429 KNPYKEVYTDMWVEPEAAA-YAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKC 487
Y+ + A + Y P P K K + E +++RE++ +V
Sbjct: 372 SRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNK 428
Query: 488 RNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL 547
++ED C+SCG N HPLF GG+CQ C++ FLE Y YDDDGYQSYCT+CC GRE+L
Sbjct: 429 SSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELL 488
Query: 548 MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQM 607
+C N +CCRCFCVEC+++LVG G A A ++PW+CYMC + +G+LRRR+DW RLQ
Sbjct: 489 LCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQA 548
Query: 608 FFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCE 667
FF ++ E++ PK+YP +PA +R+PIRVLSLFDGIATG LVLK+LGI+V +Y+ASEVCE
Sbjct: 549 FFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCE 608
Query: 668 DSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT 727
+SI VG V+H+G I YV DVR++T+K+I+EWGPFDLVIGGSPCNDLS VNPARKGLYEGT
Sbjct: 609 ESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGT 668
Query: 728 GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSA 787
GRLFFEFY LL+ +RPKEGDDRPFFW+FENVVAM V DKRDISRFLE NPVMIDA +VSA
Sbjct: 669 GRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSA 728
Query: 788 AHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQH 847
AHRARYFWGNLPGMNRP+ ++ NDKLELQ+CLE+ RIAK KV+TITT+SNSIKQGK+Q
Sbjct: 729 AHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQL 788
Query: 848 FPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE 907
FPV MN KED+LWCTE+ER+FGFPVHYTDVSNM R ARQ+LLGRSWSVPVIRHLFAPLK+
Sbjct: 789 FPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKD 848
Query: 908 YFAC 911
YFAC
Sbjct: 849 YFAC 852
>gi|28559063 DNA cytosine-5 methyltransferase 3 beta isoform 3 [Homo
sapiens]
Length = 770
Score = 650 bits (1678), Expect = 0.0
Identities = 310/538 (57%), Positives = 388/538 (72%), Gaps = 12/538 (2%)
Query: 266 GSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT 325
G ++ A D EY+DG+ FGIG+LVWGK++GFSWWP +VSW T + +A G
Sbjct: 199 GMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGM 258
Query: 326 RWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFP 385
RWV WFGDGKFS V +KL+ L F F+ AT+NK YRKA+Y L+ A RAGK FP
Sbjct: 259 RWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP 318
Query: 386 VCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEA 445
S ++E Q KPM+EWA GGF+P+G +GL+P + P + +
Sbjct: 319 -------SSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQ--PENKTRRRTADDSAT 369
Query: 446 AAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLE 505
+ Y P P K K + E +++RE++ +V ++ED C+SCG N
Sbjct: 370 SDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGRKNPVSF 426
Query: 506 HPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDL 565
HPLF GG+CQ C++ FLE Y YDDDGYQSYCT+CC GRE+L+C N +CCRCFCVEC+++
Sbjct: 427 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV 486
Query: 566 LVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPP 625
LVG G A A ++PW+CYMC + +G+LRRR+DW RLQ FF ++ E++ PK+YP
Sbjct: 487 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPA 546
Query: 626 VPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVG 685
+PA +R+PIRVLSLFDGIATG LVLK+LGI+V +Y+ASEVCE+SI VG V+H+G I YV
Sbjct: 547 IPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVN 606
Query: 686 DVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKE 745
DVR++T+K+I+EWGPFDLVIGGSPCNDLS VNPARKGLYEGTGRLFFEFY LL+ +RPKE
Sbjct: 607 DVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKE 666
Query: 746 GDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNR 803
GDDRPFFW+FENVVAM V DKRDISRFLE NPVMIDA +VSAAHRARYFWGNLPGMNR
Sbjct: 667 GDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNR 724
>gi|28559071 DNA cytosine methyltransferase 3 alpha isoform c [Homo
sapiens]
Length = 166
Score = 308 bits (788), Expect = 2e-83
Identities = 150/151 (99%), Positives = 151/151 (100%)
Query: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
Sbjct: 1 MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
Query: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
Sbjct: 61 ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG 120
Query: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGK 151
AAETLPEASRAVENGCCTPKEGRGAPAEAG+
Sbjct: 121 AAETLPEASRAVENGCCTPKEGRGAPAEAGE 151
>gi|28872780 cytosine-5-methyltransferase 3-like protein isoform 2
[Homo sapiens]
Length = 386
Score = 253 bits (646), Expect = 6e-67
Identities = 137/341 (40%), Positives = 184/341 (53%), Gaps = 31/341 (9%)
Query: 476 RERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQS 535
R+ + YEV+ RNIEDICI CGSL V +HPLF GG+C CK+ FL+ + YDDDGYQS
Sbjct: 35 RDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQS 94
Query: 536 YCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLL 595
YC+ICC G +L+CGN +C RC+C ECVD LVGPG + W CY+C GLL
Sbjct: 95 YCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLL 154
Query: 596 RRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGI 655
+RR W S+L+ F+ + +P +++ VP +R+P+RVLSLF+ I L L L
Sbjct: 155 QRRRKWRSQLKAFYDRESE---NPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLES 211
Query: 656 QVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSI 715
D G++ +V DV +K ++EWGPFDLV G +P
Sbjct: 212 GSD-------------------PGQLKHVVDVTDTVRKDVEEWGPFDLVYGATP------ 246
Query: 716 VNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES 775
P F+F+RLL ARPK G RPFFW+F + + + D SRFLE
Sbjct: 247 --PLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEM 304
Query: 776 NPVMIDAKEVSAAHRARYFWGNLPGM-NRPLASTVNDKLEL 815
PV I + A W N+P + +R A ++L L
Sbjct: 305 EPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSL 345
>gi|28872778 cytosine-5-methyltransferase 3-like protein isoform 1
[Homo sapiens]
Length = 387
Score = 253 bits (645), Expect = 7e-67
Identities = 133/326 (40%), Positives = 177/326 (54%), Gaps = 30/326 (9%)
Query: 476 RERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQS 535
R+ + YEV+ RNIEDICI CGSL V +HPLF GG+C CK+ FL+ + YDDDGYQS
Sbjct: 35 RDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQS 94
Query: 536 YCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLL 595
YC+ICC G +L+CGN +C RC+C ECVD LVGPG + W CY+C GLL
Sbjct: 95 YCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLL 154
Query: 596 RRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGI 655
+RR W S+L+ F+ + +P +++ VP +R+P+RVLSLF+ I L L L
Sbjct: 155 QRRRKWRSQLKAFYDRESE---NPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLES 211
Query: 656 QVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSI 715
D G++ +V DV +K ++EWGPFDLV G +P
Sbjct: 212 GSD-------------------PGQLKHVVDVTDTVRKDVEEWGPFDLVYGATP------ 246
Query: 716 VNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES 775
P F+F+RLL ARPK G RPFFW+F + + + D SRFLE
Sbjct: 247 --PLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEM 304
Query: 776 NPVMIDAKEVSAAHRARYFWGNLPGM 801
PV I + A W N+P +
Sbjct: 305 EPVTIPDVHGGSLQNAVRVWSNIPAI 330
>gi|148839376 PWWP domain containing 2 isoform 1 [Homo sapiens]
Length = 590
Score = 65.9 bits (159), Expect = 2e-10
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 285 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTR--WVMWFGDGKFSVVCVE 342
EDGR +G++VWGK+ GF WWP R++ + + R V WFG S + +
Sbjct: 483 EDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQKEDGEPSWREAKVSWFGSPTTSFLSIS 542
Query: 343 KLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVA 376
KL P S F + K+ MYRKAI E A
Sbjct: 543 KLSPFSEFFKL--RFNRKKKGMYRKAITEAANAA 574
>gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]
Length = 755
Score = 59.7 bits (143), Expect = 1e-08
Identities = 70/353 (19%), Positives = 136/353 (38%), Gaps = 60/353 (16%)
Query: 33 RGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGD 92
+ ++++ E ST+ + R++ SG P P V K + S L
Sbjct: 438 KAQKKQNETSTSKNAHSKVHFTRRYQNPSSGSLP--PRVRLKPQRYRNEENDSSLKTG-- 493
Query: 93 LEK----RSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAE 148
LEK + P+P+ + G AP+E + +P +G P E
Sbjct: 494 LEKMRSGKMAPKPQSRCTSTRSAGEAPSENQ------------------SPSKG---PEE 532
Query: 149 AGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLA 208
A E ++TN + + + G G SK ++
Sbjct: 533 ASSEVQDTNEVHVPGDQDEPQTLGKKG-----------------------SKNNISVYMT 569
Query: 209 RWKREAEKKAKVIAGMNAVEENQGPGESQKVEEAS--PPAVQQPTDPASPTVATTPEPVG 266
+++++ + + +++ ++ + E+ PP +S + ++ E
Sbjct: 570 LNQKKSDSSSASVCSIDSTDDLKSSNSECSSSESFDFPPGSMHAPSTSSTSSSSKEEKKL 629
Query: 267 SDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRA--AEG 324
S++ + DGR +G++VW K+ GF WWP RI++ ++ +
Sbjct: 630 SNSLKMKVFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLVRQ 689
Query: 325 TRWVMWFGDGKFSVVCVEKLMP-LSSFCSAFHQATYNKQPMYRKAIYEVLQVA 376
+ WFG S + + +L P L +F S F++ ++ +YRKAI E + A
Sbjct: 690 EARISWFGSPTTSFLALSQLSPFLENFQSRFNK---KRKGLYRKAITEAAKAA 739
>gi|51873049 hypothetical protein LOC8603 [Homo sapiens]
Length = 1224
Score = 56.2 bits (134), Expect = 1e-07
Identities = 68/282 (24%), Positives = 108/282 (38%), Gaps = 42/282 (14%)
Query: 18 EREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPS 77
+R + ++ EE+EE R KEE Q +K+ +K+K P S D PK + +
Sbjct: 901 QRRREEEEDEEEEEDRFKEEFQRLQEL-QKLRAVKKKKKERP--SKDCPKLDMLTRNFQA 957
Query: 78 MAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCC 137
+ S + NG LE+ EP+ SP+ P G GA + ++
Sbjct: 958 ATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFL 1017
Query: 138 TPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYY 197
PKE G + + + + G + L S P R T
Sbjct: 1018 LPKEVNGK-----QHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPT-------- 1064
Query: 198 ISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKV--------------EEAS 243
K E ++ + + E KAKV+ M+ E+ + E +KV +E S
Sbjct: 1065 -EPPKATEGQSKPRAQTESKAKVVDLMSITEQKR---EERKVNSNNNNKKQLNHIKDEKS 1120
Query: 244 PPAVQQPTDP------ASPTVATTPEPVGSDAGDKNATKAGD 279
P +PT P + +A +P+P G + KN K GD
Sbjct: 1121 NPTPMEPTSPGEHQQNSKLVLAESPQPKGKN--KKNKKKKGD 1160
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 53.9 bits (128), Expect = 7e-07
Identities = 72/299 (24%), Positives = 111/299 (37%), Gaps = 47/299 (15%)
Query: 7 SGPGDTSSSAAEREEDRKDGEEQEEPRGKEE--RQEPSTTARKVGRPGRKRKHPP----- 59
S PG + +E + EQ+ GKEE Q +V PG P
Sbjct: 965 SPPG--MAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQ 1022
Query: 60 ---VESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQK----- 111
VE + +Q GA L L + EP E+ GG +
Sbjct: 1023 RGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEV 1082
Query: 112 --GGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQ------KETNIESMKM 163
G PA GE AA P + V G G P +E+ +E ++E+ ++
Sbjct: 1083 MLGSEPAMGESAAGAEPGPGQGVG--------GLGDPGHLTREEVMEPPLEEESLEAKRV 1134
Query: 164 EGSRGRLR-----GGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKK- 217
+G G + GGLG E S L ++ DP+ + R+E A R AE+
Sbjct: 1135 QGLEGPRKDLEEAGGLGTEFS-------ELPGKSRDPWEPPREGREESEAEAPRGAEEAF 1187
Query: 218 -AKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNAT 275
A+ + + + P S++ EE PP + P+ +P + P P G + A+
Sbjct: 1188 PAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEAS 1246
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/289 (25%), Positives = 106/289 (36%), Gaps = 37/289 (12%)
Query: 7 SGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTP 66
S G T S AA+ E G EE +G TA K G PP ESG
Sbjct: 27 SEDGTTVSPAADNPEMSGGGAPAEETKG---------TAGKAINEG-----PPTESGKQE 72
Query: 67 KDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLP 126
K PA +D ++EL G+ E + E AGG K A AE +
Sbjct: 73 KAPA---------EDGMSAEL--QGEANGLDEVKVESQREAGG-KEDAEAELKKEDGEKE 120
Query: 127 EASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMP 186
E + + +E + P EA +++ E K E + G +++ R +P P
Sbjct: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
Query: 187 RLTFQAGDPYYISKR---KRDEWLARWKREAEKKAKVIAGMNAVEENQG---PGESQKVE 240
+ T + D S+ +R E K +A + AV E++ P E E
Sbjct: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE 240
Query: 241 EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRG 289
EA A ++ A EP G + + D E E E G G
Sbjct: 241 EAKHGAKEEADAKEEAEDAEEAEP-----GSPSEEQEQDVEKEPEGGAG 284
Score = 31.6 bits (70), Expect = 3.5
Identities = 29/114 (25%), Positives = 42/114 (36%), Gaps = 7/114 (6%)
Query: 16 AAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDT-PKDPAVISK 74
A EED K ++E + KE EP A +K + PK+P
Sbjct: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEP----D 237
Query: 75 SPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEA 128
A+ E + E E +P GSP+ Q+ E EG A +P +
Sbjct: 238 GKEEAKHGAKEEADAKEEAEDAEEAEP--GSPSEEQEQDVEKEPEGGAGVIPSS 289
Score = 30.8 bits (68), Expect = 6.0
Identities = 34/131 (25%), Positives = 48/131 (36%), Gaps = 4/131 (3%)
Query: 17 AEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSP 76
A+ +E+ +D EE E P E QE G G P E ++P +
Sbjct: 250 ADAKEEAEDAEEAE-PGSPSEEQEQDVEKEPEGGAGVIPSSPE-EWPESPTGEGHNLSTD 307
Query: 77 SMAQDSGAS-ELLPNGDLEKRSE-PQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVEN 134
+ D AS + P+ S+ PQ SP+ G+K E +A P RA
Sbjct: 308 GLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNR 367
Query: 135 GCCTPKEGRGA 145
K G A
Sbjct: 368 KAIVDKFGGAA 378
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 49.3 bits (116), Expect = 2e-05
Identities = 68/294 (23%), Positives = 113/294 (38%), Gaps = 36/294 (12%)
Query: 12 TSSSAAEREEDRKDGEEQEEPRGKEERQE------PSTTARKVGRPGRKRKHPPVESGDT 65
T E E++ K+ E +EE G+EE E S A + P ++ K P E +
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526
Query: 66 P-----------KDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPA---GGQK 111
P K PA + KSP A+ E E +S + E SPA +K
Sbjct: 527 PAEAKSPEKEEAKSPAEV-KSPEKAKSPAKEE--AKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 112 GGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKE-----TNIESMKMEGS 166
+PA+ E + P +++ E KE +PAEA KE ++S + S
Sbjct: 584 AKSPAKEEAKS---PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640
Query: 167 RGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNA 226
+ ++ ++ + +A P + ++ A+ +AE K+ A
Sbjct: 641 PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK--AKSPVKAEAKSPEKAKSPV 698
Query: 227 VEENQGPGESQ---KVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA 277
EE + P +++ K E SP + P + T PV +A K+
Sbjct: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752
Score = 41.6 bits (96), Expect = 0.003
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 15 SAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISK 74
S + EE ++ + +E P+ EE + P+T + + +K + P E+ PK K
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA---PKPKVEEKK 878
Query: 75 SPSMAQDSGASELLPNGDLE-KRSEPQPEEGSPAGGQ--KGGAPAEGEGAAETLPEASRA 131
P++ + + + E K+ P PE+ +PA + + P E A+ P+ ++A
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 132 VENGCCTPKEGRGAPAEAGKEQKETNIESMK 162
E K+ EA E+K+T E K
Sbjct: 939 KEPSKPAEKK------EAAPEKKDTKEEKAK 963
Score = 40.4 bits (93), Expect = 0.008
Identities = 37/169 (21%), Positives = 74/169 (43%), Gaps = 19/169 (11%)
Query: 5 PSSGPGDTSSSAAEREEDRKDGEEQEEPRGK------EERQEPSTTARKVGRPGRKRKHP 58
P + + A + E++KD +++E P+ + EE++EP+ K + K++
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE-- 895
Query: 59 PVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEG 118
E+ D K P ++P+ E+ + ++++E +E A ++ PAE
Sbjct: 896 --EAEDKKKVPTPEKEAPAKV------EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947
Query: 119 EGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSR 167
+ AA PE E P+E A+A ++ K + E K + +
Sbjct: 948 KEAA---PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
Score = 38.5 bits (88), Expect = 0.029
Identities = 58/277 (20%), Positives = 109/277 (39%), Gaps = 22/277 (7%)
Query: 20 EEDRKDGEEQEEPRGKEERQEPST--TARKVGRPGRKRKHPPVESGDTPKDPAVI---SK 74
+E+ K E + P KEE + P+ + K P ++ P E+ K + + +K
Sbjct: 555 KEEAKSPPEAKSPE-KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 75 SPSMAQDSGASELLPNGDL---EKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRA 131
SP+ A+ E ++ EK P EE +K +P + E + PE +++
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP--EKAKSPEKEEAKS---PEKAKS 668
Query: 132 VENGCCTPKEGRGAPAEAGKEQKETNIESMKMEG-SRGRLRGGLGWESSLRQRPMPRLTF 190
E +P +A + E +K E S + + + E+ ++ +
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 191 QAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQP 250
+A P ++E + K ++ +KAK + + ++ EEA PA + P
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL------DVKSPEAKTPAKEEARSPADKFP 782
Query: 251 TDPASPTVATTPEPVGSDAGDKNATKAGDDE-PEYED 286
SP P + + K KA + E P+ E+
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819
Score = 30.8 bits (68), Expect = 6.0
Identities = 55/286 (19%), Positives = 103/286 (36%), Gaps = 55/286 (19%)
Query: 16 AAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKS 75
A + ++ +EE + E+ + P ++ + K K P E TP+ +KS
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSP---VKEEAKSPEKAKSPVKEEAKTPEK----AKS 738
Query: 76 PSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEG--EGAAETLPEASRAVE 133
P + +++ + E + + K + + E ++ +PA+ E A + E ++ E
Sbjct: 739 P-VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Query: 134 NGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAG 193
KE AP + +++E +S +++ P+
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEV--------------------KSPVKEEEKPQEVKVKE 837
Query: 194 DPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTD- 252
P K + ++ A K E +K +K E + KVEE PAV++P +
Sbjct: 838 PP---KKAEEEKAPATPKTEEKKDSK------KEEAPKKEAPKPKVEEKKEPAVEKPKES 888
Query: 253 ---------------PASPTVATTPEPVGSDAGDKNATKAGDDEPE 283
P A V DA K T+ EP+
Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 48.1 bits (113), Expect = 4e-05
Identities = 69/276 (25%), Positives = 109/276 (39%), Gaps = 34/276 (12%)
Query: 9 PGDTSSSAAEREEDRKDGE-EQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPK 67
P A E EE+ ++ E E +E G+ + A++ P E + P+
Sbjct: 2050 PESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEA----EGEAQPESEGVEAPE 2105
Query: 68 DPAVISKSPSMAQDSGASELLPNGD----LEKRSEPQPE-EGSPAGGQKGGAPAEGEGAA 122
K+ + E P + E E QPE EG A +G A E EG
Sbjct: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGI- 2164
Query: 123 ETLPEASRAVENGCCTPK-EGRGAPAEAGKEQKETN-IESMKMEG-SRGRLRGGLGWESS 179
EA A E P+ EG AP G+ Q E+ IE+ + EG ++ L G E+
Sbjct: 2165 ----EAQEAEEEA--QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE 2218
Query: 180 LRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKV 239
+P P + E A+ + E E + + + + + G G+S++
Sbjct: 2219 EEAQPEPEGV----------ETPEAEGEAQPESEGETQGEK---KGSPQVSLGDGQSEEA 2265
Query: 240 EEASPPAVQ-QPTDPASPTVATTPEPVGSDAGDKNA 274
E+S P + +PT P SP T + GS G ++
Sbjct: 2266 SESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSS 2301
Score = 38.1 bits (87), Expect = 0.038
Identities = 71/310 (22%), Positives = 116/310 (37%), Gaps = 30/310 (9%)
Query: 5 PSSGPGDTSSSAAEREEDRKDGEEQE-EPRGKEERQEPSTTARKVGRPGRKRKHPPVESG 63
P S ++ + E + + +D E E E +E E + V P + + E
Sbjct: 1956 PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE 2015
Query: 64 DTPKDPAVISKSPSM---AQDSGASELLPNGDLEKRSE--PQPEEGSPAGGQKGGAP-AE 117
P+ V ++ S AQ+ GD + S+ PE A +G AE
Sbjct: 2016 AQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075
Query: 118 GEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWE 177
GE E+ ++ E EG AP G+ QK IE+ + EG G+
Sbjct: 2076 GEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135
Query: 178 SSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAK-VIAGMNAVE-ENQGPGE 235
+ + +A D ++ + + A +EAE++A+ + G+ A E E + E
Sbjct: 2136 EAEGEAQPESEGVEAQDAEGEAQPESEGIEA---QEAEEEAQPELEGVEAPEAEGEAQPE 2192
Query: 236 SQKVE------EASP-------PAVQQPTDPASPTVATTPEPVG----SDAGDKNATKAG 278
S+ +E EA P P ++ P P TPE G G+ K G
Sbjct: 2193 SEGIEAPEAEGEAQPELEGVEAPEAEEEAQP-EPEGVETPEAEGEAQPESEGETQGEKKG 2251
Query: 279 DDEPEYEDGR 288
+ DG+
Sbjct: 2252 SPQVSLGDGQ 2261
Score = 35.8 bits (81), Expect = 0.19
Identities = 33/135 (24%), Positives = 50/135 (37%), Gaps = 11/135 (8%)
Query: 10 GDTSSSAAEREEDRKDGEEQEEPRG---KEERQEPSTTARKVGRPGRKRKHPPVESGDTP 66
G+ + E +GE Q E G E +E V P + + P G+T
Sbjct: 2187 GEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
Query: 67 KDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLP 126
+ SP ++ G SE + + S P PE+ GG ++T P
Sbjct: 2247 GEK---KGSPQVSLGDGQSE-----EASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGP 2298
Query: 127 EASRAVENGCCTPKE 141
+SRA G C K+
Sbjct: 2299 SSSRASSWGNCWQKD 2313
Score = 33.5 bits (75), Expect = 0.93
Identities = 68/304 (22%), Positives = 109/304 (35%), Gaps = 35/304 (11%)
Query: 5 PSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGD 64
P G + + A ERE + E E QE + + G+ H G+
Sbjct: 1758 PKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGE 1817
Query: 65 TP----KDPAVISKSPSMAQDSGASELLPNGD----LEKRSEPQPEEGSPAGGQKGGAPA 116
+DP + + E P + E + Q EG +
Sbjct: 1818 AAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAP 1877
Query: 117 EGEGAAETLPEASRAVENGCCTPKEGRGAPA-EAGKE-QKET-NIESMKMEG-SRGRLRG 172
E EG A+ E E E GA A EA KE Q ET ++E+++ EG G
Sbjct: 1878 EAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEG 1937
Query: 173 GLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNA-VEENQ 231
E+ + T + I ++ +E EA+ +++ + + VE +
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESE--VIESQEAEE-------EAQPESEDVEALEVEVETQE 1988
Query: 232 GPGESQKVEE--ASPPA------VQQPTDPASPTVATTPEPVGSDA----GDKNATKAGD 279
GE+Q E +P A ++ P S V P+ G +A G+ T+ GD
Sbjct: 1989 AEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE-GD 2047
Query: 280 DEPE 283
+PE
Sbjct: 2048 AQPE 2051
Score = 32.7 bits (73), Expect = 1.6
Identities = 30/107 (28%), Positives = 41/107 (38%), Gaps = 9/107 (8%)
Query: 20 EEDRKDGEEQEE---PRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSP 76
EE G+E E P GK +++ + GR + P E + P +P S
Sbjct: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEP----PSH 1456
Query: 77 SMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAE 123
D ASE LE E P G+ GQ+ +GAAE
Sbjct: 1457 LSETDPSASERQSGSQLEPGLEKPP--GATMMGQEHTQAQPTQGAAE 1501
Score = 31.2 bits (69), Expect = 4.6
Identities = 62/246 (25%), Positives = 80/246 (32%), Gaps = 39/246 (15%)
Query: 61 ESGDTPKDPAVISKSPS-MAQDSGASELLPNGDLEKRSEPQPEE------GSPAGG---- 109
++G PA I S SGA+ L G+ E R PQP G P G
Sbjct: 765 DAGSRTCSPAPIPPHTSDSCSKSGAASL---GE-EARDTPQPSSPLVLQVGRPEQGAVGP 820
Query: 110 -------QKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMK 162
Q G PA+ E PEAS C TP GR P T
Sbjct: 821 HRSHCCSQPGTQPAQ-EAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTG----S 875
Query: 163 MEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIA 222
S R GG E + + P P G S+R A + +E+K
Sbjct: 876 SHQSTARGPGGSPQEGTRQPGPTP----SPGPNSGASRRSSASQGAGSRGLSEEKTLRSG 931
Query: 223 GMNAVEENQGPGESQKVEEASPPAVQQ------PTDPASPTVATTPEPVGSDAGDKNATK 276
G +E + +SP AV + P +P T E G+ G +
Sbjct: 932 GGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPE 991
Query: 277 A--GDD 280
GDD
Sbjct: 992 VDPGDD 997
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 47.8 bits (112), Expect = 5e-05
Identities = 62/284 (21%), Positives = 98/284 (34%), Gaps = 50/284 (17%)
Query: 10 GDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDP 69
G+ E EE ++ EE++E GKEE + + G ++K + ++
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790
Query: 70 AVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEAS 129
D G E E+ +E + EE G +GG EG+G E E
Sbjct: 791 G----------DQGEGE-------EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG 833
Query: 130 RA-VENGCCTPKEGRGAPAEA-GKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR 187
E G +EG G E GK ++E + EG G G
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG--------------- 878
Query: 188 LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAV 247
+ +E + E E + + G EE +G GE ++ EE
Sbjct: 879 --------------EEEEGEGEGEEEGEGEGEEEEGEGEGEE-EGEGEGEE-EEGEGKGE 922
Query: 248 QQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFG 291
++ + E G D + + G+ E E E+G G G
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966
Score = 39.3 bits (90), Expect = 0.017
Identities = 40/174 (22%), Positives = 61/174 (35%), Gaps = 15/174 (8%)
Query: 8 GPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKH---PPVESGD 64
G + E EE+ +GE +EE G+ E +E + G + + E G+
Sbjct: 867 GEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 65 TPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAG------GQKGGAPAEG 118
+ + +D G+ E E EG G G+ G EG
Sbjct: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
Query: 119 EGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRG 172
EG E E G EG G+E++E +E ++EG G G
Sbjct: 987 EGEGEEEEGEEEGEEEG-----EGEEEGEGEGEEEEEGEVEG-EVEGEEGEGEG 1034
Score = 38.9 bits (89), Expect = 0.022
Identities = 53/244 (21%), Positives = 88/244 (36%), Gaps = 20/244 (8%)
Query: 18 EREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGR-----KRKHPPVESGDTPKDPAVI 72
E EE+ +GE +EE G+ E +E + G G + E G+ +
Sbjct: 894 EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEG 953
Query: 73 SKSPSMAQDSGASELLPNGDLEK----------RSEPQPEEGSPAGGQKGGAPAEGEGAA 122
+ G E G+ E+ E + EEG G ++G EGEG
Sbjct: 954 EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG 1013
Query: 123 ETLPEASRAVENGCCTPKEGRG-APAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLR 181
E E G +EG G E G+E+ E + + E +R E +
Sbjct: 1014 E---EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070
Query: 182 QRPMPRLTFQAGDPY-YISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE 240
+ Q G+ Y +SK K + K +K G + ++ P +S+++
Sbjct: 1071 ETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLL 1130
Query: 241 EASP 244
+ P
Sbjct: 1131 KNGP 1134
Score = 37.7 bits (86), Expect = 0.049
Identities = 42/173 (24%), Positives = 58/173 (33%), Gaps = 8/173 (4%)
Query: 8 GPGDTSSSAAEREEDRKDGEEQ-EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTP 66
G G+ E EE GEE+ EE G+EE +E + G + E +
Sbjct: 840 GEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEE 899
Query: 67 KDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAG--GQKGGAPAEGEGAAET 124
+ + ++ E E + EEG G G+ G EGE E
Sbjct: 900 GEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEE 959
Query: 125 LPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWE 177
E G EG G E E++E E + EG G G E
Sbjct: 960 EEGEGEGEEEG-----EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEE 1007
Score = 37.4 bits (85), Expect = 0.064
Identities = 67/315 (21%), Positives = 107/315 (33%), Gaps = 40/315 (12%)
Query: 9 PGDTSSSAAERE---EDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDT 65
P T + ++ E + K+G E + G EE++ + GRK K + T
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 66 PKDPAVISKSPSMAQDSGASELLPNGDLEKRSEP----QPEEGSPAGGQKGGAPAE--GE 119
K K+ S+ + E +G E+ S Q EE KG E GE
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE 691
Query: 120 GAAETL-----------------------PEASRAVENGCCTPKEGRGAPAEAGKEQKET 156
G E E ++ +E G + G G E +E++E
Sbjct: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG-GEEEHGEGEEEEGDREEEEE 750
Query: 157 NIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEK 216
K EG + G E R++ + G+ +E E E+
Sbjct: 751 KEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEE 810
Query: 217 KAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATK 276
+V G VEE +G E ++ E + + E G + G++
Sbjct: 811 GGEVEGG--EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE---- 864
Query: 277 AGDDEPEYEDGRGFG 291
G+ E E E+G G G
Sbjct: 865 -GEGEEEGEEGEGEG 878
Score = 32.3 bits (72), Expect = 2.1
Identities = 15/49 (30%), Positives = 24/49 (48%)
Query: 8 GPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRK 56
G G+ E EE K+GE +E R +EE +E ++ G +R+
Sbjct: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 46.2 bits (108), Expect = 1e-04
Identities = 45/153 (29%), Positives = 60/153 (39%), Gaps = 13/153 (8%)
Query: 26 GEEQEEPRGKEERQEPSTTA--RKVGRPGRKRKHPPVES-GDTPKDPAVISKSPSMAQDS 82
G P G E + PS T R G G + P E+ G P PA + S ++
Sbjct: 523 GPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETP 582
Query: 83 GASELLPNGD--LEKRSE-PQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTP 139
G S P D E SE P P PAG + +P+E G P E+ TP
Sbjct: 583 GPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETP 642
Query: 140 KEG-----RGAPAEAGK--EQKETNIESMKMEG 165
R PA+AG+ E ++ +ES G
Sbjct: 643 GPSPAGPTRDEPAKAGEAAELQDAEVESSAKSG 675
Score = 40.8 bits (94), Expect = 0.006
Identities = 40/130 (30%), Positives = 52/130 (40%), Gaps = 10/130 (7%)
Query: 34 GKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGD- 92
G EE E T K G PG + P G +P PA + S ++ G P GD
Sbjct: 499 GVEEDTE-GRTGPKEGTPGSPSETP----GPSPAGPAGDEPAESPSETPGPRPAGPAGDE 553
Query: 93 -LEKRSE-PQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAG 150
E SE P P PAG + +P+E G + P E+ TP P AG
Sbjct: 554 PAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPAGP--AG 611
Query: 151 KEQKETNIES 160
E E+ E+
Sbjct: 612 DEPAESPSET 621
Score = 36.2 bits (82), Expect = 0.14
Identities = 70/298 (23%), Positives = 100/298 (33%), Gaps = 36/298 (12%)
Query: 6 SSGPGDTSSSAAEREEDRKDGEEQEEPRGKE------ERQEPSTTARKVGRPGR--KRKH 57
S G G R + +D E +G E +R EP + R +R+
Sbjct: 335 SKGGGRVDEGPQPRSVEPQDAGPLERSQGDEAGGHGEDRPEPLSPKESKKRKLELSRREQ 394
Query: 58 PPVESGDTPKDPAVISKSPSMAQDSGASE-LLPNGDLEKRSEPQPEEGSPAGGQKGGAPA 116
PP E G P+ + + K + S+ L G E + E P G A
Sbjct: 395 PPTEPG--PQSASEVEKIALNLEGCALSQGSLRTGTQEVGGQDPGEAVQPCRQPLGARVA 452
Query: 117 EGEGAAETLPEA---SRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGG 173
+ + E S AV +G G+PA +G K + E+ E + GR
Sbjct: 453 DKVRKRRKVDEGAGDSAAVASGGAQTLALAGSPAPSG-HPKAGHSENGVEEDTEGRTGPK 511
Query: 174 LGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGP 233
G S + P P AGD S +E AG E + P
Sbjct: 512 EGTPGSPSETPGPSPAGPAGDEPAESP-------------SETPGPRPAGPAGDEPAESP 558
Query: 234 GESQKVEEASPPAVQQPTDPA-----SPTVATTPEPVGSDA---GDKNATKAGDDEPE 283
E+ A P + P+ SP T EP S + G + A AGD+ E
Sbjct: 559 SETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAE 616
Score = 34.7 bits (78), Expect = 0.42
Identities = 35/121 (28%), Positives = 45/121 (37%), Gaps = 8/121 (6%)
Query: 77 SMAQDSGASELLPNGD--LEKRSE-PQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVE 133
S ++ G S P GD E SE P P PAG + +P+E G P E
Sbjct: 517 SPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAE 576
Query: 134 NGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAG 193
+ TP P+ AG + E + G R G S + P PR AG
Sbjct: 577 SPSETP-----GPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAG 631
Query: 194 D 194
D
Sbjct: 632 D 632
Score = 34.7 bits (78), Expect = 0.42
Identities = 36/140 (25%), Positives = 47/140 (33%), Gaps = 11/140 (7%)
Query: 5 PSSGPGDTSSSAAEREE----DRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV 60
PS PG + A E G P G E + PS T P + P
Sbjct: 538 PSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGP--SPAGPTRDEPA 595
Query: 61 ES-----GDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAP 115
ES G P PA + S ++ G P GD S + SPAG +
Sbjct: 596 ESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPA 655
Query: 116 AEGEGAAETLPEASRAVENG 135
GE A E + ++G
Sbjct: 656 KAGEAAELQDAEVESSAKSG 675
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/168 (22%), Positives = 59/168 (35%), Gaps = 11/168 (6%)
Query: 426 EEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQ 485
E+ N E M P+ P P K + P+ + +T E L
Sbjct: 105 EDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKT-ENLKKRGED 163
Query: 486 KCRNIEDICISCGSL------NVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTI 539
I C +CG + HP +C+NC ++ D DG C
Sbjct: 164 GLHGIVS-CTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRW 222
Query: 540 CCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKE-DPWNCYMC 586
C G ++ C + C FC +C+ +G + E + W CY+C
Sbjct: 223 CAEGGNLICC--DFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYIC 268
Score = 34.7 bits (78), Expect = 0.42
Identities = 47/220 (21%), Positives = 85/220 (38%), Gaps = 16/220 (7%)
Query: 9 PGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKD 68
PGD + E D EE ++PR + T G G ++K P E K+
Sbjct: 1311 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSD-GESGEEKKTKPKEH----KE 1365
Query: 69 PAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEA 128
++ ++DS S+ +G E+ SE + E+ K E + + + +
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1425
Query: 129 SR-------AVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLR 181
R + EN + +E E +E++E E + + S+ +G L+
Sbjct: 1426 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILK 1485
Query: 182 QRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVI 221
+ T A + +R + +A +RE EK +VI
Sbjct: 1486 DDKLRTETQNA----LKEEEERRKRIAEREREREKLREVI 1521
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/150 (24%), Positives = 58/150 (38%), Gaps = 16/150 (10%)
Query: 451 PPPAKKPRKSTAEKPKVKEIIDE-RTRERLVYEVRQKCRNIED------ICISCGSL--- 500
P K +S EKP E ++E + E ++ + ED C +CG
Sbjct: 83 PSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKEDGLHGIVSCTACGQQVNH 142
Query: 501 ---NVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRC 557
+ HP +C+NC ++ D DG C C G ++ C + C
Sbjct: 143 FQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICC--DFCHNA 200
Query: 558 FCVECVDLLVGPGAAQAAIKE-DPWNCYMC 586
FC +C+ +G + E + W CY+C
Sbjct: 201 FCKKCILRNLGRKELSTIMDENNQWYCYIC 230
Score = 34.7 bits (78), Expect = 0.42
Identities = 47/220 (21%), Positives = 85/220 (38%), Gaps = 16/220 (7%)
Query: 9 PGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKD 68
PGD + E D EE ++PR + T G G ++K P E K+
Sbjct: 1273 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSD-GESGEEKKTKPKEH----KE 1327
Query: 69 PAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEA 128
++ ++DS S+ +G E+ SE + E+ K E + + + +
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1387
Query: 129 SR-------AVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLR 181
R + EN + +E E +E++E E + + S+ +G L+
Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILK 1447
Query: 182 QRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVI 221
+ T A + +R + +A +RE EK +VI
Sbjct: 1448 DDKLRTETQNA----LKEEEERRKRIAEREREREKLREVI 1483
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 45.1 bits (105), Expect = 3e-04
Identities = 71/309 (22%), Positives = 116/309 (37%), Gaps = 52/309 (16%)
Query: 2 PAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVE 61
P M S+G D+SS D D E +P K + + S+ + K P RK P +
Sbjct: 188 PGMVSAGQADSSSEDTSSSSDETDVE--GKPSVKPAQVKASSVSTKES-PARKAAPAPGK 244
Query: 62 SGD-TPK------DPAVISKSP-----SMAQDSGASELLPNGD----------LEKRSEP 99
GD TP+ PA +K P S + S + E P G L+ R+
Sbjct: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 100 QPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIE 159
P +G+P G P + GA + +A + E + + E+ ++ET
Sbjct: 305 APAKGTPGKGATPAPPGKA-GAVASQTKAGKPEE-------DSESSSEESSDSEEETPAA 356
Query: 160 SMKMEGSRGRLRGGLGWESS-LRQRPM-------PRLTFQAGDPYYISKRKRDEWLARWK 211
++ +G S+ ++ P P T A KR+ D + +
Sbjct: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
Query: 212 REAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGD 271
++E++A A + G++ +V AS PA + P A+P P G A
Sbjct: 417 SDSEEEAPAQA--------KPSGKAPQVRAASAPAKESPRKGAAP---APPRKTGPAAAQ 465
Query: 272 KNATKAGDD 280
K +D
Sbjct: 466 VQVGKQEED 474
Score = 33.5 bits (75), Expect = 0.93
Identities = 43/174 (24%), Positives = 66/174 (37%), Gaps = 15/174 (8%)
Query: 2 PAMPS-SGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQ-EPSTTARKVGRPGRKRKHPP 59
PA P +GP + A +REED + E+ + + Q +PS A +V K P
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 60 VESGDTPKDPAVISKSPSMAQ------DSGASELLPNGDLEKRSEPQPEEGSPAGGQKGG 113
G P P + + Q DS +S + D E + + P G
Sbjct: 448 -RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 114 APAEGEGAAETLPEASRAVENGCCTPKEGRGAP-AEAGKEQKETNIESMKMEGS 166
PA G L + + V G K G P A+ GK ++++ S + S
Sbjct: 507 KPASTMGMG-PLGKGAGPVPPG----KVGPATPSAQVGKWEEDSESSSEESSDS 555
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 45.1 bits (105), Expect = 3e-04
Identities = 71/309 (22%), Positives = 116/309 (37%), Gaps = 52/309 (16%)
Query: 2 PAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVE 61
P M S+G D+SS D D E +P K + + S+ + K P RK P +
Sbjct: 188 PGMVSAGQADSSSEDTSSSSDETDVE--GKPSVKPAQVKASSVSTKES-PARKAAPAPGK 244
Query: 62 SGD-TPK------DPAVISKSP-----SMAQDSGASELLPNGD----------LEKRSEP 99
GD TP+ PA +K P S + S + E P G L+ R+
Sbjct: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 100 QPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIE 159
P +G+P G P + GA + +A + E + + E+ ++ET
Sbjct: 305 APAKGTPGKGATPAPPGKA-GAVASQTKAGKPEE-------DSESSSEESSDSEEETPAA 356
Query: 160 SMKMEGSRGRLRGGLGWESS-LRQRPM-------PRLTFQAGDPYYISKRKRDEWLARWK 211
++ +G S+ ++ P P T A KR+ D + +
Sbjct: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
Query: 212 REAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGD 271
++E++A A + G++ +V AS PA + P A+P P G A
Sbjct: 417 SDSEEEAPAQA--------KPSGKAPQVRAASAPAKESPRKGAAP---APPRKTGPAAAQ 465
Query: 272 KNATKAGDD 280
K +D
Sbjct: 466 VQVGKQEED 474
Score = 33.5 bits (75), Expect = 0.93
Identities = 43/174 (24%), Positives = 66/174 (37%), Gaps = 15/174 (8%)
Query: 2 PAMPS-SGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQ-EPSTTARKVGRPGRKRKHPP 59
PA P +GP + A +REED + E+ + + Q +PS A +V K P
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 60 VESGDTPKDPAVISKSPSMAQ------DSGASELLPNGDLEKRSEPQPEEGSPAGGQKGG 113
G P P + + Q DS +S + D E + + P G
Sbjct: 448 -RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 114 APAEGEGAAETLPEASRAVENGCCTPKEGRGAP-AEAGKEQKETNIESMKMEGS 166
PA G L + + V G K G P A+ GK ++++ S + S
Sbjct: 507 KPASTMGMG-PLGKGAGPVPPG----KVGPATPSAQVGKWEEDSESSSEESSDS 555
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 45.1 bits (105), Expect = 3e-04
Identities = 71/309 (22%), Positives = 116/309 (37%), Gaps = 52/309 (16%)
Query: 2 PAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVE 61
P M S+G D+SS D D E +P K + + S+ + K P RK P +
Sbjct: 188 PGMVSAGQADSSSEDTSSSSDETDVE--GKPSVKPAQVKASSVSTKES-PARKAAPAPGK 244
Query: 62 SGD-TPK------DPAVISKSP-----SMAQDSGASELLPNGD----------LEKRSEP 99
GD TP+ PA +K P S + S + E P G L+ R+
Sbjct: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 100 QPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIE 159
P +G+P G P + GA + +A + E + + E+ ++ET
Sbjct: 305 APAKGTPGKGATPAPPGKA-GAVASQTKAGKPEE-------DSESSSEESSDSEEETPAA 356
Query: 160 SMKMEGSRGRLRGGLGWESS-LRQRPM-------PRLTFQAGDPYYISKRKRDEWLARWK 211
++ +G S+ ++ P P T A KR+ D + +
Sbjct: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
Query: 212 REAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGD 271
++E++A A + G++ +V AS PA + P A+P P G A
Sbjct: 417 SDSEEEAPAQA--------KPSGKAPQVRAASAPAKESPRKGAAP---APPRKTGPAAAQ 465
Query: 272 KNATKAGDD 280
K +D
Sbjct: 466 VQVGKQEED 474
Score = 33.5 bits (75), Expect = 0.93
Identities = 43/174 (24%), Positives = 66/174 (37%), Gaps = 15/174 (8%)
Query: 2 PAMPS-SGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQ-EPSTTARKVGRPGRKRKHPP 59
PA P +GP + A +REED + E+ + + Q +PS A +V K P
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 60 VESGDTPKDPAVISKSPSMAQ------DSGASELLPNGDLEKRSEPQPEEGSPAGGQKGG 113
G P P + + Q DS +S + D E + + P G
Sbjct: 448 -RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 114 APAEGEGAAETLPEASRAVENGCCTPKEGRGAP-AEAGKEQKETNIESMKMEGS 166
PA G L + + V G K G P A+ GK ++++ S + S
Sbjct: 507 KPASTMGMG-PLGKGAGPVPPG----KVGPATPSAQVGKWEEDSESSSEESSDS 555
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 45.1 bits (105), Expect = 3e-04
Identities = 71/309 (22%), Positives = 116/309 (37%), Gaps = 52/309 (16%)
Query: 2 PAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVE 61
P M S+G D+SS D D E +P K + + S+ + K P RK P +
Sbjct: 188 PGMVSAGQADSSSEDTSSSSDETDVE--GKPSVKPAQVKASSVSTKES-PARKAAPAPGK 244
Query: 62 SGD-TPK------DPAVISKSP-----SMAQDSGASELLPNGD----------LEKRSEP 99
GD TP+ PA +K P S + S + E P G L+ R+
Sbjct: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 100 QPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIE 159
P +G+P G P + GA + +A + E + + E+ ++ET
Sbjct: 305 APAKGTPGKGATPAPPGKA-GAVASQTKAGKPEE-------DSESSSEESSDSEEETPAA 356
Query: 160 SMKMEGSRGRLRGGLGWESS-LRQRPM-------PRLTFQAGDPYYISKRKRDEWLARWK 211
++ +G S+ ++ P P T A KR+ D + +
Sbjct: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
Query: 212 REAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGD 271
++E++A A + G++ +V AS PA + P A+P P G A
Sbjct: 417 SDSEEEAPAQA--------KPSGKAPQVRAASAPAKESPRKGAAP---APPRKTGPAAAQ 465
Query: 272 KNATKAGDD 280
K +D
Sbjct: 466 VQVGKQEED 474
Score = 33.5 bits (75), Expect = 0.93
Identities = 43/174 (24%), Positives = 66/174 (37%), Gaps = 15/174 (8%)
Query: 2 PAMPS-SGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQ-EPSTTARKVGRPGRKRKHPP 59
PA P +GP + A +REED + E+ + + Q +PS A +V K P
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 60 VESGDTPKDPAVISKSPSMAQ------DSGASELLPNGDLEKRSEPQPEEGSPAGGQKGG 113
G P P + + Q DS +S + D E + + P G
Sbjct: 448 -RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 114 APAEGEGAAETLPEASRAVENGCCTPKEGRGAP-AEAGKEQKETNIESMKMEGS 166
PA G L + + V G K G P A+ GK ++++ S + S
Sbjct: 507 KPASTMGMG-PLGKGAGPVPPG----KVGPATPSAQVGKWEEDSESSSEESSDS 555
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/136 (29%), Positives = 60/136 (44%), Gaps = 11/136 (8%)
Query: 11 DTSSSAAEREEDRKDGEEQEE-PRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTP--- 66
D SSS+ E E + +QEE P+G +E+ + S + + P ++ + TP
Sbjct: 276 DGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEK 335
Query: 67 ---KDPAVISKSPSMAQ-DSGASELL--PNGDLEKRSEPQPEEGSPAGGQKGGAP-AEGE 119
KD + S S + DS AS L + E +P GS G + G P AEG
Sbjct: 336 KRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGG 395
Query: 120 GAAETLPEASRAVENG 135
+ TL A+ +E G
Sbjct: 396 STSSTLRAAASKLEQG 411
Score = 30.8 bits (68), Expect = 6.0
Identities = 31/154 (20%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 19 REEDRKDGEEQEEPRGKEERQE----------------PSTTARKVGRPGRKRKHPPVES 62
+++D+ + EE++E RG+ + E + + GR + +K P+
Sbjct: 183 KDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAK 242
Query: 63 GDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAA 122
G K D A E +GD E + +GS + ++ E + A
Sbjct: 243 GGR-------KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEE----PESKAKA 291
Query: 123 ETLPEASRAVENGCCTPKEG-RGAPAEAGKEQKE 155
E + V+ + +E P E KE++E
Sbjct: 292 PQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEE 325
>gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [Homo
sapiens]
Length = 747
Score = 44.3 bits (103), Expect = 5e-04
Identities = 36/122 (29%), Positives = 53/122 (43%), Gaps = 10/122 (8%)
Query: 3 AMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVES 62
A GPG + EED ++ EE EE ++E +EP A+ +G+ + PP +
Sbjct: 65 AASGGGPG------GDEEEDEEEEEEDEEALLEDEDEEP-PPAQALGQAAQPPPEPPEAA 117
Query: 63 G-DTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGA 121
+ +P K SG L KR E +PEE S G + G+ G+ A
Sbjct: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS--GDETPGSEVPGDKA 175
Query: 122 AE 123
AE
Sbjct: 176 AE 177
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 43.9 bits (102), Expect = 7e-04
Identities = 34/130 (26%), Positives = 49/130 (37%), Gaps = 2/130 (1%)
Query: 25 DGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGA 84
D EE E G RQ+PS + ++ RP P +G T + + + S GA
Sbjct: 27 DEEEDAEEEGAGGRQDPSRRSIRL-RP-LPSPSPSAAAGGTESRSSALGAADSEGPARGA 84
Query: 85 SELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRG 144
+ NGD + GS GG G G E R + G +P E R
Sbjct: 85 GKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRT 144
Query: 145 APAEAGKEQK 154
P A + ++
Sbjct: 145 PPGLAAEPER 154
>gi|239756562 PREDICTED: hypothetical protein [Homo sapiens]
Length = 235
Score = 43.9 bits (102), Expect = 7e-04
Identities = 49/158 (31%), Positives = 62/158 (39%), Gaps = 19/158 (12%)
Query: 33 RGKEERQEPSTTARKVGRPGRKR--KHPPVESGDTPKDPAVISKSPSMAQDSGASELLPN 90
RG+ ER+ A K G PGR+R K PP T P + PS QD+G +
Sbjct: 77 RGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAP---QRCPS--QDAGRA----- 126
Query: 91 GDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAE---TLPEASRAVENGCCTPKE--GRGA 145
G RS PQ G A GA G G E P A+ A G + K+ RG
Sbjct: 127 GSRVCRSRPQSRGGQKAAA--SGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKPRRRGQ 184
Query: 146 PAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQR 183
A K + K + + RGG G + R R
Sbjct: 185 KAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKKPRRGR 222
>gi|11560152 zinc finger protein 335 [Homo sapiens]
Length = 1342
Score = 43.9 bits (102), Expect = 7e-04
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 17/151 (11%)
Query: 20 EEDRKDGEEQEEPRGKEER-QEPS-TTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPS 77
EED ++EPRG++ R Q P+ +T R RPGR RK P +E D P + P
Sbjct: 318 EEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDG---VEGEPL 374
Query: 78 MAQDSGASELLPNGDLEKRSEPQPEEGSPAGG------QKGGAPAEGEGAAETLPEASRA 131
++ SG S P D E S P G + G + ++ E AA + P+
Sbjct: 375 VSSQSGQSPPEPQ-DPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPD---- 429
Query: 132 VENGCCTPKEGRGAPAEAGKEQKETNIESMK 162
E+ + GR + GK+ ++ +S K
Sbjct: 430 -EHDTLPRRRGRPSRRFLGKKYRKYYYKSPK 459
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,322,687
Number of Sequences: 37866
Number of extensions: 2334795
Number of successful extensions: 17425
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 558
Number of HSP's that attempted gapping in prelim test: 14849
Number of HSP's gapped (non-prelim): 2723
length of query: 912
length of database: 18,247,518
effective HSP length: 111
effective length of query: 801
effective length of database: 14,044,392
effective search space: 11249557992
effective search space used: 11249557992
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.