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Search of human proteins with 27894376
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27894376 cell adhesion molecule with homology to L1CAM
precursor [Homo sapiens]
(1224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 2510 0.0
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 879 0.0
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 875 0.0
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 838 0.0
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 833 0.0
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 829 0.0
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 827 0.0
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 827 0.0
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 819 0.0
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 709 0.0
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 412 e-114
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 406 e-113
gi|4827022 contactin 2 precursor [Homo sapiens] 395 e-109
gi|75709184 contactin 3 [Homo sapiens] 375 e-103
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 356 9e-98
gi|7657361 contactin 6 [Homo sapiens] 355 1e-97
gi|7657359 contactin 5 isoform long [Homo sapiens] 348 2e-95
gi|28373129 contactin 5 isoform short [Homo sapiens] 347 4e-95
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 344 3e-94
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 344 3e-94
gi|119220552 sidekick 1 [Homo sapiens] 284 4e-76
gi|222352127 sidekick 2 [Homo sapiens] 270 6e-72
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 268 3e-71
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 225 2e-58
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 214 4e-55
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 211 4e-54
gi|157311649 neogenin homolog 1 [Homo sapiens] 197 4e-50
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 196 1e-49
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 195 2e-49
gi|19743806 roundabout 1 isoform b [Homo sapiens] 184 6e-46
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 2510 bits (6506), Expect = 0.0
Identities = 1224/1224 (100%), Positives = 1224/1224 (100%)
Query: 1 MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAK 60
MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAK
Sbjct: 1 MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAK 60
Query: 61 GNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMS 120
GNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMS
Sbjct: 61 GNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMS 120
Query: 121 EEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERV 180
EEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERV
Sbjct: 121 EEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERV 180
Query: 181 YMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIG 240
YMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIG
Sbjct: 181 YMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIG 240
Query: 241 SKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKG 300
SKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKG
Sbjct: 241 SKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKG 300
Query: 301 RETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYST 360
RETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYST
Sbjct: 301 RETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYST 360
Query: 361 GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEAS 420
GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEAS
Sbjct: 361 GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEAS 420
Query: 421 NVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVK 480
NVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVK
Sbjct: 421 NVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVK 480
Query: 481 PLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNP 540
PLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNP
Sbjct: 481 PLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNP 540
Query: 541 RIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLE 600
RIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLE
Sbjct: 541 RIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLE 600
Query: 601 DQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISE 660
DQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISE
Sbjct: 601 DQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISE 660
Query: 661 YIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH 720
YIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH
Sbjct: 661 YIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH 720
Query: 721 ETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEET 780
ETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEET
Sbjct: 721 ETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEET 780
Query: 781 VTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINST 840
VTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINST
Sbjct: 781 VTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINST 840
Query: 841 LVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDA 900
LVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDA
Sbjct: 841 LVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDA 900
Query: 901 FSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNG 960
FSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNG
Sbjct: 901 FSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNG 960
Query: 961 NLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP 1020
NLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP
Sbjct: 961 NLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP 1020
Query: 1021 ITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIE 1080
ITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIE
Sbjct: 1021 ITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIE 1080
Query: 1081 TRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPE 1140
TRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPE
Sbjct: 1081 TRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPE 1140
Query: 1141 IQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGA 1200
IQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGA
Sbjct: 1141 IQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGA 1200
Query: 1201 YAGSKEKGSVESNGSSTATFPLRA 1224
YAGSKEKGSVESNGSSTATFPLRA
Sbjct: 1201 YAGSKEKGSVESNGSSTATFPLRA 1224
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 879 bits (2271), Expect = 0.0
Identities = 514/1305 (39%), Positives = 716/1305 (54%), Gaps = 103/1305 (7%)
Query: 6 LGRGLIVYLMFLLLKFSKAIEIP------SSVQQVPTIIKQSKVQVAFPFDEYFQIECEA 59
L G + ++FL S A+E+P + Q PTI +QS E I+CEA
Sbjct: 12 LSAGRVPLILFLCQMIS-ALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEA 70
Query: 60 KGNPEPTFSWTKDGNPFYFTDHRII---PSNNSGTFRIPNEGHISHFQGKYRCFASNKLG 116
KG P P+FSWT++G F ++ P + I +EG ++G Y+C A N+ G
Sbjct: 71 KGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERG 130
Query: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQ 176
A+S I P + KEK++P+ ++ G +VLPC PP GLPP I+WM+ + + Q
Sbjct: 131 AAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQ 190
Query: 177 DERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSS 236
ERV GDLYF+NV +D+R DY C+A F +TI QK P+ + V S+ ND+ ++
Sbjct: 191 SERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAA 250
Query: 237 TEIGSK---ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKI 293
++ A S ++R P L P G+ S+ L+G +L LEC AEGLPTP + W K
Sbjct: 251 NLSDTEFYGAKSSRERPPTFLTP---EGNASNKEELRGNVLSLECIAEGLPTPIIYWAKE 307
Query: 294 GGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKP 353
G LPK R +N+ KTL+I +VS D GNY+C A N LG H V V+ P W P
Sbjct: 308 DGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAP 367
Query: 354 QSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNL 407
Q+ V S G +G L+C A G P+P I W NG P++ P GD + F+N+
Sbjct: 368 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII-----FSNV 422
Query: 408 QPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASP 467
Q +AVYQC ASN +G +LANA ++V+ P I T Y + A L C FF SP
Sbjct: 423 QERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSP 482
Query: 468 EAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI 527
+ W K + L Y ++ENGTL+I ++ G+Y+C N +G +L+I
Sbjct: 483 LPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEI 542
Query: 528 RNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIII 587
++ T + P+ + + M+ C+ K D L SL + W KD D R +
Sbjct: 543 KDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTL--SLTVLWLKDNRELP----SDERFTV 596
Query: 588 DGANLTISNVTLEDQGIYCCSAHTALDS----------AADITQVTVLDVPDPPENLHLS 637
D +L +++V+ +D G Y C A+T LDS A T V DVP+PP +L L+
Sbjct: 597 DKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELT 656
Query: 638 ERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVR 697
++ ++SV+L+W G D+NS I+++I+E+E +PG W T V G +TT L L+P+V
Sbjct: 657 DQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVN 716
Query: 698 YQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQN 757
Y FRV+AVN +G+S PS+ S+ + T + PD+NP + S+P ++I W+PL E N
Sbjct: 717 YSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESN 776
Query: 758 GPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPA-VYAPYDVKVQAINQLGSGPDPQSV 816
GPGL+Y+V+W+ + EW V N + +++ + PY +KVQA+N +G P+P V
Sbjct: 777 GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVV 836
Query: 817 TLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRT 876
+SGED P AP V+V+NSTL +V W VP + G L+GY+I +WKT+S
Sbjct: 837 MGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNR 896
Query: 877 HPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPT 936
E IL F G + GM+P L+ FS + L V N KG GP S +F TPEGVP P+
Sbjct: 897 RHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPS 956
Query: 937 FLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHL 996
LK++ D+ TL W P NG LT Y L+YQ IN T+E+G L D+ I +K W L
Sbjct: 957 SLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPA-NKTRWTL 1015
Query: 997 SNLNATTKYKFYLRACTSQGCGKPITEES-STLGEG-----SKGIGKISGVN-------- 1042
NLN +T+YKFY A TS G G ITEE+ +T+ E G GK+ VN
Sbjct: 1016 KNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTA 1075
Query: 1043 LTQKTHPIEVFE-PGAEHI-------VRLMTKNW-------------------------- 1068
+T+ +E G EH+ V + W
Sbjct: 1076 AAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVR 1135
Query: 1069 ----GDNDSI-FQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNR 1123
GD+ + +DV ET G A DI+TQGWFIGLMCA+ALL L+LL VCF++RN+
Sbjct: 1136 VGAVGDSGFVSSEDVFET-GPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNK 1194
Query: 1124 GGKYSVKEKEDLHPDPEIQSVK--DETFGEYSDS-DEKPL-KGSLRSLNRDMQPTESADS 1179
GGKY VKEKED H DPEIQ +K D TFGEYSD+ D KPL KGS +R ++ +S DS
Sbjct: 1195 GGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDS 1254
Query: 1180 LVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPLRA 1224
LV+YGEG +G F+EDGSFIG Y+G KEK E N SS A P+ A
Sbjct: 1255 LVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNA 1299
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 875 bits (2261), Expect = 0.0
Identities = 492/1236 (39%), Positives = 688/1236 (55%), Gaps = 86/1236 (6%)
Query: 6 LGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEP 65
L G + ++FL S A+E+P + Q PTI +QS E I+CEAKG P P
Sbjct: 12 LSAGRVPLILFLCQMIS-ALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPP 70
Query: 66 TFSWTKDGNPFYFTDHRII---PSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEE 122
+FSWT++G F ++ P + I +EG ++G Y+C A N+ G A+S
Sbjct: 71 SFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNN 130
Query: 123 IEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYM 182
I P + KEK++P+ ++ G +VLPC PP GLPP I+WM+ + + Q ERV
Sbjct: 131 IVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQ 190
Query: 183 SQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSK 242
GDLYF+NV +D+R DY C+A F +TI QK P+ + V S+ ND+ ++ ++
Sbjct: 191 GLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTE 250
Query: 243 ---ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK 299
A S ++R P L P G+ S+ L+G +L LEC AEGLPTP + W K G LPK
Sbjct: 251 FYGAKSSRERPPTFLTP---EGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPK 307
Query: 300 GRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYS 359
R +N+ KTL+I +VS D GNY+C A N LG H V V+ P W PQ+ V S
Sbjct: 308 NRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLS 367
Query: 360 TGSNGILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTA 413
G +G L+C A G P+P I W NG P++ P GD + F+N+Q +A
Sbjct: 368 PGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII-----FSNVQERSSA 422
Query: 414 VYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSW 473
VYQC ASN +G +LANA ++V+ P I T Y + A L C FF SP + W
Sbjct: 423 VYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 482
Query: 474 QKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKL 533
K + L Y ++ENGTL+I ++ G+Y+C N +G +L+I++ T +
Sbjct: 483 FKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWI 542
Query: 534 RVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLT 593
P+ + + M+ C+ K D L SL + W KD D R +D +L
Sbjct: 543 VKQPEYAVVQRGSMVSFECKVKHDHTL--SLTVLWLKDNRELP----SDERFTVDKDHLV 596
Query: 594 ISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGAD 653
+++V+ +D G Y C A+T LDS + ++V+DVP+PP +L L+++ ++SV+L+W G D
Sbjct: 597 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDD 656
Query: 654 HNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQP 713
+NS I+++I+E+E +PG W T V G +TT L L+P+V Y FRV+AVN +G+S P
Sbjct: 657 NNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLP 716
Query: 714 SQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAP 773
S+ S+ + T + PD+NP + S+P ++I W+PL E NGPGL+Y+V+W+ +
Sbjct: 717 SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGD 776
Query: 774 VEWEEETVTNHTLRVMT-PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIH 832
EW V N + +++ + PY +KVQA+N +G P+P V +SGED P AP
Sbjct: 777 DEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNV 836
Query: 833 GVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNS 892
V+V+NSTL +V W VP + G L+GY+I +WKT+S E IL F G +
Sbjct: 837 RVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTH 896
Query: 893 GMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSW 952
GM+P L+ FS + L V N KG GP S +F TPEGVP P+ LK++ D+ TL W
Sbjct: 897 GMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEW 956
Query: 953 GLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRAC 1012
P NG LT Y L+YQ IN T+E+G L D+ I +K W L NLN +T+YKFY A
Sbjct: 957 DPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPA-NKTRWTLKNLNFSTRYKFYFYAQ 1015
Query: 1013 TSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDND 1072
TS G G ITEE+ T V E A V + T+
Sbjct: 1016 TSAGSGSQITEEAVT-----------------------TVDEAMASRQVDIATQ------ 1046
Query: 1073 SIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEK 1132
GWFIGLMCA+ALL L+LL VCF++RN+GGKY VKEK
Sbjct: 1047 ------------------------GWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEK 1082
Query: 1133 EDLHPDPEIQSVK--DETFGEYSDS-DEKPL-KGSLRSLNRDMQPTESADSLVEYGEGDH 1188
ED H DPEIQ +K D TFGEYSD+ D KPL KGS +R ++ +S DSLV+YGEG +
Sbjct: 1083 EDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVN 1142
Query: 1189 GLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPLRA 1224
G F+EDGSFIG Y+G KEK E N SS A P+ A
Sbjct: 1143 GQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNA 1178
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 838 bits (2165), Expect = 0.0
Identities = 478/1254 (38%), Positives = 680/1254 (54%), Gaps = 88/1254 (7%)
Query: 25 IEIPSSVQQVPTIIKQSKVQ-VAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDH-- 81
I+IP + + P I +QS + V FP D+ ++CEA G PE F WT+DG F +
Sbjct: 20 IQIPEELMEPPVITEQSPRRLVVFPTDD-ISLKCEASGKPEVQFRWTRDGVHFKPKEELG 78
Query: 82 -RIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKI 138
+ S +SG+F I N FQG YRCFASNKLG AMS EI + PK+PKE +
Sbjct: 79 VTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETV 138
Query: 139 DPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDS 198
P+EVEEG+ +VLPCNPP PL IYWMN ++ HI+QDERV M Q G+LYFANV D+
Sbjct: 139 KPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDN 198
Query: 199 RNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPT 258
+DY C A FP RTI+QK P+ L V + NS+ RKP+LL P
Sbjct: 199 HSDYICHAHFPGTRTIIQKEPIDLRVKA----------------TNSMIDRKPRLLFP-- 240
Query: 259 ESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSY 318
+ S S + L+G+ L+LEC AEG PTP + W + G +P R T +N+ KTL++ V
Sbjct: 241 -TNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 299
Query: 319 QDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTI 378
+D G YRC A N LG+A H ++V VE P W KPQS +Y G L C+ +G PQP +
Sbjct: 300 EDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV 359
Query: 379 KWRVNGSPVDNHPFAGDVVFPRE---ISFTNLQPNHTAVYQCEASNVHGTILANANIDVV 435
WR+NG PV+ A D + + + +N+QP+ T V QCEA N HG +LANA I VV
Sbjct: 360 TWRINGIPVEE--LAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 417
Query: 436 DVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTL 495
+ I T D + Y V G +A+L C+ F +P V W + L+ R+ Y NGTL
Sbjct: 418 QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTL 477
Query: 496 QINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESK 555
I D G Y C N + ANL +++AT++ P++ K + C++
Sbjct: 478 GIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQAS 537
Query: 556 CDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDS 615
D L+ S+ +W DG + G D I DG L I ++ DQG Y C A T LD
Sbjct: 538 FDPSLQPSI--TWRGDGRDLQELGDSDKYFIEDG-RLVIHSLDYSDQGNYSCVASTELDV 594
Query: 616 AADITQVTVLDVPDPPENLHLSERQ---NRSVRLTWEAGADHNSNISEYIVEFEGNKEEP 672
Q+ V+ P P L LS+ VR++W DHN+ I +Y +EFE + P
Sbjct: 595 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 654
Query: 673 GRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQ 732
+W L +V G +T+ L L+P+V Y FRV A+N+ G +PS S+ TP AAP++NP
Sbjct: 655 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 714
Query: 733 NIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPA 792
+++ + ++ M+I W+PL+ M+ N P ++YRV W+PQG W+E+ V++ L V +
Sbjct: 715 DVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTS 774
Query: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
+ PY++KVQA+N G GP+PQ YSGEDYP P + G++++NS+ V V W V
Sbjct: 775 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 834
Query: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYN 912
+V G L+GY + +W+ S + + S ++ L +S +HL V A+N
Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 894
Query: 913 SKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQII 972
+G+GP SE + F TPEGVP P L + + L W P NG LTGY+L Y +
Sbjct: 895 GRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 953
Query: 973 NDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLG-EG 1031
++ + G+L+ N+ P + +L++L+ +Y+F L+A T +G G+ I E T+ G
Sbjct: 954 DEGGK-GQLS-FNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSG 1011
Query: 1032 SKGIGKISG------------------------------------------VNLTQKTHP 1049
G IS V+ Q ++
Sbjct: 1012 ISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYT 1071
Query: 1050 IEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAGLYD-DISTQGWFIGLMCAIAL 1108
+P ++ + L + + Q ++T G L +T+GWFIG + AI L
Sbjct: 1072 QWDLQPDTDYEIHLFKERMFRH----QMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIIL 1127
Query: 1109 LTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEYSDSDEKPLKGSLRSLN 1168
L L+LL +CF+KR++GGKYSVK+KED D E + +KDETFGEYSD++EK S SLN
Sbjct: 1128 LLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSSQPSLN 1187
Query: 1169 RDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPL 1222
D++P S DSL +YG F+EDGSFIG Y+G KEK + N SS AT P+
Sbjct: 1188 GDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPI 1241
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 833 bits (2152), Expect = 0.0
Identities = 479/1259 (38%), Positives = 680/1259 (54%), Gaps = 93/1259 (7%)
Query: 25 IEIPSS-----VQQVPTIIKQSKVQ-VAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYF 78
I+IP V + P I +QS + V FP D+ ++CEA G PE F WT+DG F
Sbjct: 20 IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD-ISLKCEASGKPEVQFRWTRDGVHFKP 78
Query: 79 TDH---RIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKF 133
+ + S +SG+F I N FQG YRCFASNKLG AMS EI + PK+
Sbjct: 79 KEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW 138
Query: 134 PKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANV 193
PKE + P+EVEEG+ +VLPCNPP PL IYWMN ++ HI+QDERV M Q G+LYFANV
Sbjct: 139 PKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANV 198
Query: 194 EEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKL 253
D+ +DY C A FP RTI+QK P+ L V + NS+ RKP+L
Sbjct: 199 LTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKA----------------TNSMIDRKPRL 242
Query: 254 LLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKI 313
L P + S S + L+G+ L+LEC AEG PTP + W + G +P R T +N+ KTL++
Sbjct: 243 LFP---TNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQL 299
Query: 314 ENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGE 373
V +D G YRC A N LG+A H ++V VE P W KPQS +Y G L C+ +G
Sbjct: 300 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGR 359
Query: 374 PQPTIKWRVNGSPVDNHPFAGDVVFPRE---ISFTNLQPNHTAVYQCEASNVHGTILANA 430
PQP + WR+NG PV+ A D + + + +N+QP+ T V QCEA N HG +LANA
Sbjct: 360 PQPEVTWRINGIPVEE--LAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 431 NIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIY 490
I VV + I T D + Y V G +A+L C+ F +P V W + L+ R+ Y
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPY 477
Query: 491 ENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLEL 550
NGTL I D G Y C N + ANL +++AT++ P++ K +
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTF 537
Query: 551 HCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAH 610
C++ D L+ S+ +W DG + G D I DG L I ++ DQG Y C A
Sbjct: 538 TCQASFDPSLQPSI--TWRGDGRDLQELGDSDKYFIEDG-RLVIHSLDYSDQGNYSCVAS 594
Query: 611 TALDSAADITQVTVLDVPDPPENLHLSERQ---NRSVRLTWEAGADHNSNISEYIVEFEG 667
T LD Q+ V+ P P L LS+ VR++W DHN+ I +Y +EFE
Sbjct: 595 TELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFED 654
Query: 668 NKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
+ P +W L +V G +T+ L L+P+V Y FRV A+N+ G +PS S+ TP AAP
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAP 714
Query: 728 DRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLR 787
++NP +++ + ++ M+I W+PL+ M+ N P ++YRV W+PQG W+E+ V++ L
Sbjct: 715 EKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV 774
Query: 788 VMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWS 847
V + + PY++KVQA+N G GP+PQ YSGEDYP P + G++++NS+ V V W
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834
Query: 848 TVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLT 907
V +V G L+GY + +W+ S + + S ++ L +S +HL
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLE 894
Query: 908 VLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLL 967
V A+N +G+GP SE + F TPEGVP P L + + L W P NG LTGY+L
Sbjct: 895 VQAFNGRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVL 953
Query: 968 QYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESST 1027
Y +++ + G+L+ N+ P + +L++L+ +Y+F L+A T +G G+ I E T
Sbjct: 954 SYHPLDEGGK-GQLS-FNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGT 1011
Query: 1028 LG-EGSKGIGKISG------------------------------------------VNLT 1044
+ G G IS V+
Sbjct: 1012 MALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYN 1071
Query: 1045 QKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAGLYD-DISTQGWFIGLM 1103
Q ++ +P ++ + L + + Q ++T G L +T+GWFIG +
Sbjct: 1072 QSSYTQWDLQPDTDYEIHLFKERMFRH----QMAVKTNGTGRVRLPPAGFATEGWFIGFV 1127
Query: 1104 CAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEYSDSDEKPLKGS 1163
AI LL L+LL +CF+KR++GGKYSVK+KED D E + +KDETFGEYSD++EK S
Sbjct: 1128 SAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSS 1187
Query: 1164 LRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPL 1222
SLN D++P S DSL +YG F+EDGSFIG Y+G KEK + N SS AT P+
Sbjct: 1188 QPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPI 1246
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 829 bits (2141), Expect = 0.0
Identities = 478/1221 (39%), Positives = 661/1221 (54%), Gaps = 77/1221 (6%)
Query: 15 MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73
+ LL AIEIP + Q PTI KQS K + P D IECEAKGNP P+F WT++
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
Query: 74 NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
F D R+ SGT I + G ++G+Y+CFA NK G A+S I V
Sbjct: 74 RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
Query: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190
P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV GDLYF
Sbjct: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
Query: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGS-KANSIKQR 249
+NV +D + DY C A F TI QK P L V + NDSS A + +R
Sbjct: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAER 253
Query: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309
P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + EN+ K
Sbjct: 254 TPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK 310
Query: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369
L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G L+C
Sbjct: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCR 370
Query: 370 AEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC SN H
Sbjct: 371 ANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEH 425
Query: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
G +LANA + V+DV P + + + ++ L C FF SP + W K + L+
Sbjct: 426 GYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIP 543
G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P++
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 544 KLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQG 603
+ ++L C K D LK L +SW KD E I R+ + +LTI V DQG
Sbjct: 546 RGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQG 599
Query: 604 IYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIV 663
Y C A T LD +TVL PD P +L L++ RSVRLTW G +NS I++Y+V
Sbjct: 600 SYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVV 659
Query: 664 EFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETP 723
+FE ++ +PG W + ++ G + +L L+P+V YQFRVIA+NEVG S PS PS+ + T
Sbjct: 660 QFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS 719
Query: 724 PAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN 783
A P+ NP +++ + ++ M I W P+ + GP L Y V W+ + W TV
Sbjct: 720 GAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWG 779
Query: 784 HTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVK 843
V VY PY+++VQA N G GP+P+SV YSGEDYP AP V V+NST +
Sbjct: 780 SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAIS 839
Query: 844 VTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSE 903
+ W+ V D V G+L+ Y+ +W+ SLL ++ F G R G+V L +S
Sbjct: 840 LQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSN 899
Query: 904 FHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLT 963
+ L ++ N +G GP SE F TPEGVP P +V + + +T L W P+ NG +
Sbjct: 900 YKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMI 959
Query: 964 GYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITE 1023
GY L+Y N T ++G+ + +P++ + + + ++Y+F L A T G G+ +TE
Sbjct: 960 GYTLKYVAFNGT-KVGK-QIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTE 1017
Query: 1024 ESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRG 1083
ES P P A
Sbjct: 1018 ESPA---------------------PPNEATPTA-------------------------- 1030
Query: 1084 REYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQS 1143
Y DI+TQGWFIGLMCAIALL L+LL VCF+KR+RGGKY V+EK+D+ PE
Sbjct: 1031 -AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPK 1089
Query: 1144 VKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAG 1203
+D +F +YSD D KPL+GS SL+ ++ ES DSLV+YGEG G F+EDGSFIG Y
Sbjct: 1090 EEDGSF-DYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTV 1148
Query: 1204 SKEKGSVESNGSSTATFPLRA 1224
K+K E N SS AT P+ A
Sbjct: 1149 KKDKEETEGNESSEATSPVNA 1169
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 827 bits (2137), Expect = 0.0
Identities = 479/1263 (37%), Positives = 680/1263 (53%), Gaps = 97/1263 (7%)
Query: 25 IEIPSS-----VQQVPTIIKQSKVQ-VAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYF 78
I+IP V + P I +QS + V FP D+ ++CEA G PE F WT+DG F
Sbjct: 20 IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD-ISLKCEASGKPEVQFRWTRDGVHFKP 78
Query: 79 TDH---RIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKF 133
+ + S +SG+F I N FQG YRCFASNKLG AMS EI + PK+
Sbjct: 79 KEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW 138
Query: 134 PKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANV 193
PKE + P+EVEEG+ +VLPCNPP PL IYWMN ++ HI+QDERV M Q G+LYFANV
Sbjct: 139 PKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANV 198
Query: 194 EEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKL 253
D+ +DY C A FP RTI+QK P+ L V + NS+ RKP+L
Sbjct: 199 LTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKA----------------TNSMIDRKPRL 242
Query: 254 LLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKI 313
L P + S S + L+G+ L+LEC AEG PTP + W + G +P R T +N+ KTL++
Sbjct: 243 LFP---TNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQL 299
Query: 314 ENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGE 373
V +D G YRC A N LG+A H ++V VE P W KPQS +Y G L C+ +G
Sbjct: 300 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGR 359
Query: 374 PQPTIKWRVNGSPVDNHPFAGDVVFPRE---ISFTNLQPNHTAVYQCEASNVHGTILANA 430
PQP + WR+NG PV+ A D + + + +N+QP+ T V QCEA N HG +LANA
Sbjct: 360 PQPEVTWRINGIPVEE--LAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 431 NIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIY 490
I VV + I T D + Y V G +A+L C+ F +P V W + L+ R+ Y
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPY 477
Query: 491 ENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLEL 550
NGTL I D G Y C N + ANL +++AT++ P++ K +
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTF 537
Query: 551 HCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAH 610
C++ D L+ S+ +W DG + G D I DG L I ++ DQG Y C A
Sbjct: 538 TCQASFDPSLQPSI--TWRGDGRDLQELGDSDKYFIEDG-RLVIHSLDYSDQGNYSCVAS 594
Query: 611 TALDSAADITQVTVLDVPDPPENLHLSERQ---NRSVRLTWEAGADHNSNISEYIVEFEG 667
T LD Q+ V+ P P L LS+ VR++W DHN+ I +Y +EFE
Sbjct: 595 TELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFED 654
Query: 668 NKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
+ P +W L +V G +T+ L L+P+V Y FRV A+N+ G +PS S+ TP AAP
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAP 714
Query: 728 DRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLR 787
++NP +++ + ++ M+I W+PL+ M+ N P ++YRV W+PQG W+E+ V++ L
Sbjct: 715 EKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV 774
Query: 788 VMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWS 847
V + + PY++KVQA+N G GP+PQ YSGEDYP P + G++++NS+ V V W
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834
Query: 848 TVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLT 907
V +V G L+GY + +W+ S + + S ++ L +S +HL
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLE 894
Query: 908 VLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLL 967
V A+N +G+GP SE + F TPEGVP P L + + L W P NG LTGY+L
Sbjct: 895 VQAFNGRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVL 953
Query: 968 QYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESST 1027
Y +++ + G+L+ N+ P + +L++L+ +Y+F L+A T +G G+ I E T
Sbjct: 954 SYHPLDEGGK-GQLS-FNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGT 1011
Query: 1028 LG-EGSKGIGKISG------------------------------------------VNLT 1044
+ G G IS V+
Sbjct: 1012 MALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYN 1071
Query: 1045 QKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAGLYD-DISTQGWFIGLM 1103
Q ++ +P ++ + L + + Q ++T G L +T+GWFIG +
Sbjct: 1072 QSSYTQWDLQPDTDYEIHLFKERMFRH----QMAVKTNGTGRVRLPPAGFATEGWFIGFV 1127
Query: 1104 CAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEY----SDSDEKP 1159
AI LL L+LL +CF+KR++GGKYSVK+KED D E + +KDETFGEY SD++EK
Sbjct: 1128 SAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKA 1187
Query: 1160 LKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTAT 1219
S SLN D++P S DSL +YG F+EDGSFIG Y+G KEK + N SS AT
Sbjct: 1188 FGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGAT 1247
Query: 1220 FPL 1222
P+
Sbjct: 1248 SPI 1250
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 827 bits (2136), Expect = 0.0
Identities = 478/1221 (39%), Positives = 662/1221 (54%), Gaps = 82/1221 (6%)
Query: 15 MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73
+ LL AIEIP + Q PTI KQS K + P D IECEAKGNP P+F WT++
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
Query: 74 NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
F D R+ SGT I + G ++G+Y+CFA NK G A+S I V
Sbjct: 74 RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
Query: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190
P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV GDLYF
Sbjct: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
Query: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGS-KANSIKQR 249
+NV +D + DY C A F TI QK P L V + NDSS A + +R
Sbjct: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAER 253
Query: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309
P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + EN+ K
Sbjct: 254 TPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK 310
Query: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369
L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G L+C
Sbjct: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCR 370
Query: 370 AEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC SN H
Sbjct: 371 ANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEH 425
Query: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
G +LANA + V+DV P + + + ++ L C FF SP + W K + L+
Sbjct: 426 GYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIP 543
G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P++
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 544 KLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQG 603
+ ++L C K D LK L +SW KD E I R+ + +LTI V DQG
Sbjct: 546 RGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQG 599
Query: 604 IYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIV 663
Y C A T LD +TVL PD P +L L++ RSVRLTW G +NS I++Y+V
Sbjct: 600 SYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVV 659
Query: 664 EFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETP 723
+FE ++ +PG W + ++ G + +L L+P+V YQFRVIA+NEVG S PS PS+ + T
Sbjct: 660 QFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS 719
Query: 724 PAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN 783
A P+ NP +++ + ++ M I W P+ + GP L Y V W+ + W TV
Sbjct: 720 GAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWG 779
Query: 784 HTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVK 843
V VY PY+++VQA N G GP+P+SV YSGEDYP AP V V+NST +
Sbjct: 780 SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAIS 839
Query: 844 VTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSE 903
+ W+ V D V G+L+ Y+ +W+ SLL ++ F G R G+V L +S
Sbjct: 840 LQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSN 899
Query: 904 FHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLT 963
+ L ++ N +G GP SE F TPEGVP P +V + + +T L W P+ NG +
Sbjct: 900 YKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMI 959
Query: 964 GYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITE 1023
GY L+Y N T ++G+ + +P++ + + + ++Y+F L A T G G+ +TE
Sbjct: 960 GYTLKYVAFNGT-KVGK-QIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTE 1017
Query: 1024 ESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRG 1083
ES P E + T N D
Sbjct: 1018 ES--------------------PAPPNEAY-----------TNNQAD------------- 1033
Query: 1084 REYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQS 1143
I+TQGWFIGLMCAIALL L+LL VCF+KR+RGGKY V+EK+D+ PE
Sbjct: 1034 ---------IATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPK 1084
Query: 1144 VKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAG 1203
+D +F +YSD D KPL+GS SL+ ++ ES DSLV+YGEG G F+EDGSFIG Y
Sbjct: 1085 EEDGSF-DYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTV 1143
Query: 1204 SKEKGSVESNGSSTATFPLRA 1224
K+K E N SS AT P+ A
Sbjct: 1144 KKDKEETEGNESSEATSPVNA 1164
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 819 bits (2115), Expect = 0.0
Identities = 478/1236 (38%), Positives = 661/1236 (53%), Gaps = 92/1236 (7%)
Query: 15 MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73
+ LL AIEIP + Q PTI KQS K + P D IECEAKGNP P+F WT++
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
Query: 74 NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
F D R+ SGT I + G ++G+Y+CFA NK G A+S I V
Sbjct: 74 RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
Query: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190
P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV GDLYF
Sbjct: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
Query: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGS-KANSIKQR 249
+NV +D + DY C A F TI QK P L V + NDSS A + +R
Sbjct: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAER 253
Query: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309
P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + EN+ K
Sbjct: 254 TPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK 310
Query: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369
L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G L+C
Sbjct: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCR 370
Query: 370 AEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC SN H
Sbjct: 371 ANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEH 425
Query: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
G +LANA + V+DV P + + + ++ L C FF SP + W K + L+
Sbjct: 426 GYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIP 543
G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P++
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 544 KLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQG 603
+ ++L C K D LK L +SW KD E I R+ + +LTI V DQG
Sbjct: 546 RGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQG 599
Query: 604 IYCCSAHTALDSAADITQVTVL---------------DVPDPPENLHLSERQNRSVRLTW 648
Y C A T LD +TVL PD P +L L++ RSVRLTW
Sbjct: 600 SYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTW 659
Query: 649 EAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEV 708
G +NS I++Y+V+FE ++ +PG W + ++ G + +L L+P+V YQFRVIA+NEV
Sbjct: 660 IPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEV 719
Query: 709 GRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWK 768
G S PS PS+ + T A P+ NP +++ + ++ M I W P+ + GP L Y V W+
Sbjct: 720 GSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR 779
Query: 769 PQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTA 828
+ W TV V VY PY+++VQA N G GP+P+SV YSGEDYP A
Sbjct: 780 RRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAA 839
Query: 829 PVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSG 888
P V V+NST + + W+ V D V G+L+ Y+ +W+ SLL ++ F G
Sbjct: 840 PTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPG 899
Query: 889 QRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTA 948
R G+V L +S + L ++ N +G GP SE F TPEGVP P +V + + +T
Sbjct: 900 DRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETI 959
Query: 949 TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY 1008
L W P+ NG + GY L+Y N T ++G+ + +P++ + + + ++Y+F
Sbjct: 960 NLEWDHPEHPNGIMIGYTLKYVAFNGT-KVGK-QIVENFSPNQTKFTVQRTDPVSRYRFT 1017
Query: 1009 LRACTSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNW 1068
L A T G G+ +TEES P P A
Sbjct: 1018 LSARTQVGSGEAVTEESPA---------------------PPNEATPTA----------- 1045
Query: 1069 GDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYS 1128
Y DI+TQGWFIGLMCAIALL L+LL VCF+KR+RGGKY
Sbjct: 1046 ----------------AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYP 1089
Query: 1129 VKEKEDLHPDPEIQSVKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDH 1188
V+EK+D+ PE +D +F +YSD D KPL+GS SL+ ++ ES DSLV+YGEG
Sbjct: 1090 VREKKDVPLGPEDPKEEDGSF-DYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGE 1148
Query: 1189 GLFSEDGSFIGAYAGSKEKGSVESNGSSTATFPLRA 1224
G F+EDGSFIG Y K+K E N SS AT P+ A
Sbjct: 1149 GQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNA 1184
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 709 bits (1831), Expect = 0.0
Identities = 456/1270 (35%), Positives = 642/1270 (50%), Gaps = 109/1270 (8%)
Query: 15 MFLLLKFSKAIEIP------SSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTF 67
+ LL AIEIP + + Q PTI KQS K + P D IECEAKGNP P+F
Sbjct: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSF 73
Query: 68 SWTKDGNPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIE 124
WT++ F D R+ SGT I + G ++G+Y+CFA NK G A+S I
Sbjct: 74 HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIR 133
Query: 125 FIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQ 184
V P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV
Sbjct: 134 LQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH 193
Query: 185 KGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKAN 244
GDLYF+NV +D + DY C A F TI QK P L V + +
Sbjct: 194 NGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR---------------- 237
Query: 245 SIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETK 304
+ +R P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP +
Sbjct: 238 GVAERTPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKF 294
Query: 305 ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNG 364
EN+ K L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G
Sbjct: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354
Query: 365 ILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCE 418
L+C A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC
Sbjct: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCN 409
Query: 419 ASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEE 478
SN HG +LANA + V+DV P + + + ++ L C FF SP + W K +
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 469
Query: 479 VKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPK 538
L+G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P+
Sbjct: 470 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529
Query: 539 NPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVT 598
+ + ++L C K D LK L +SW KD E I R+ + +LTI V
Sbjct: 530 DQVARRGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVA 583
Query: 599 LEDQGIYCCSAHTALDSAADITQVTVL---------------DVPDPPENLHLSERQNRS 643
DQG Y C A T LD +TVL PD P +L L++ RS
Sbjct: 584 ERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERS 643
Query: 644 VRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVI 703
VRLTW G +NS I++Y+V+FE ++ +PG W + ++ G + +L L+P+V YQFRVI
Sbjct: 644 VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI 703
Query: 704 AVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEY 763
A+NEVG S PS PS+ + T A P+ NP +++ + ++ M I W P+ + GP L Y
Sbjct: 704 AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY 763
Query: 764 RVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGED 823
V W+ + W TV V VY PY+++VQA N G GP+P+SV YSGED
Sbjct: 764 IVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGED 823
Query: 824 YPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNI 883
P +AP V N + + W + +G + GY + + +G K++ +
Sbjct: 824 LP-SAPRRFRVRQPNLETINLEWD--HPEHPNGIMIGYTLKY----VAFNGTKVGKQI-V 875
Query: 884 LRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAG---------PESEPYIFQTPEGVPEQ 934
FS + V D S + T+ A G+G P +E P +P
Sbjct: 876 ENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLP-- 933
Query: 935 PTFLKVI-KVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPS 993
PT + V AT + + + I T + TT + +
Sbjct: 934 PTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIATTT----TVATTTTTTAAATT 989
Query: 994 WHLSNLNATTKYKFYLRACTSQGCGKPITEESS---------TLGEGSKGIGKISGVNLT 1044
S T+ K + A Q +S G G+ + + N T
Sbjct: 990 TTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHT 1049
Query: 1045 QKTHPIEV---------FEPGAEHIVRLMTKNWGDNDSIFQDVIE-TRGREYAGLYDDIS 1094
+KT P++ PG + +R+ ++ DN+ I VI Y DI+
Sbjct: 1050 KKTVPVKAQAQPIQLTDLYPGMTYTLRVYSR---DNEGISSTVITFMTSTAYTNNQADIA 1106
Query: 1095 TQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDETFGEYSD 1154
TQGWFIGLMCAIALL L+LL VCF+KR+RGGKY V+EK+D+ PE +D +F +YSD
Sbjct: 1107 TQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSF-DYSD 1165
Query: 1155 SDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNG 1214
D KPL+GS SL+ ++ ES DSLV+YGEG G F+EDGSFIG Y K+K E N
Sbjct: 1166 EDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNE 1225
Query: 1215 SSTATFPLRA 1224
SS AT P+ A
Sbjct: 1226 SSEATSPVNA 1235
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 412 bits (1059), Expect = e-114
Identities = 240/621 (38%), Positives = 330/621 (53%), Gaps = 41/621 (6%)
Query: 15 MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73
+ LL AIEIP + Q PTI KQS K + P D IECEAKGNP P+F WT++
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
Query: 74 NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
F D R+ SGT I + G ++G+Y+CFA NK G A+S I V
Sbjct: 74 RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
Query: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190
P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV GDLYF
Sbjct: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
Query: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRK 250
+NV +D + DY C A F TI QK P L V + + + +R
Sbjct: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR----------------GVAERT 237
Query: 251 PKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKT 310
P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + EN+ K
Sbjct: 238 PSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
Query: 311 LKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA 370
L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G L+C A
Sbjct: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354
Query: 371 EGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVHG 424
G P+PT++W VNG P+ + P AGD + F + Q + AVYQC SN HG
Sbjct: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEHG 409
Query: 425 TILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEG 484
+LANA + V+DV P + + + ++ L C FF SP + W K + L+G
Sbjct: 410 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 469
Query: 485 RRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPK 544
YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P++ +
Sbjct: 470 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 529
Query: 545 LHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGI 604
++L C K D LK L +SW KD E I R+ + +LTI V DQG
Sbjct: 530 GTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIG----NRMKKEDDSLTIFGVAERDQGS 583
Query: 605 YCCSAHTALDSAADITQVTVL 625
Y C A T LD +TVL
Sbjct: 584 YTCVASTELDQDLAKAYLTVL 604
Score = 82.0 bits (201), Expect = 3e-15
Identities = 128/582 (21%), Positives = 209/582 (35%), Gaps = 93/582 (15%)
Query: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM-NIELEH 173
L + + EI + P K+ V+ D I++ C KG P +W N +
Sbjct: 19 LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEA-KGNPAPSFHWTRNSRFFN 77
Query: 174 IEQDERVYMSQKGDLYFANVEE----KDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKH 229
I +D RV M ++ + ++ +Y CFA
Sbjct: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR---------------------- 115
Query: 230 ANDSSSSTEIGSK-ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAE-GLPTPQ 287
+ G+ +N I+ + K L P E+ + + +G L L+C GLP+P
Sbjct: 116 -------NKFGTALSNRIRLQVSKSPLWPKEN--LDPVVVQEGAPLTLQCNPPPGLPSPV 166
Query: 288 VDWNKIGGD-LPKGRETKENYGKTLKIENVSYQD-KGNYRCTASNFLGTATHDFHVIVEE 345
+ W + + + + + + L NV QD + +Y C A H H I ++
Sbjct: 167 IFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR------FHFTHTIQQK 220
Query: 346 PPRWTKK---------------PQSAVYST----GSNGILLCEAEGEPQPTIKWRVNGS- 385
P K PQ S G + +L C A G P P I W G
Sbjct: 221 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGD 280
Query: 386 -PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTK 444
P D F F + + TN+ + Y C ASN G+I ++ V +
Sbjct: 281 LPSDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD-- 335
Query: 445 DGENYATVVGYSAFLHCEFFASPEAVVSW----QKVEEVKPLEGRRYHIYENGTLQINRT 500
+ +N G L C +P+ V W + ++ P R T+ T
Sbjct: 336 EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDT 392
Query: 501 TEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHL 560
Y C N G A + + + +SP+N I + L+ ++ D
Sbjct: 393 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI----LYNRTRLDCPF 448
Query: 561 KHSL--KLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAAD 618
S L W K+G+ ++G + + +L I + EDQGIY C A L A +
Sbjct: 449 FGSPIPTLRWFKNGQGSNLDG--GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
Query: 619 ITQVTVLDVPDPPENLHLSERQ--NRSVRLTWEAGADHNSNI 658
+ L+V DP + E Q R + E H+ ++
Sbjct: 507 QVR---LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSL 545
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 406 bits (1044), Expect = e-113
Identities = 240/627 (38%), Positives = 331/627 (52%), Gaps = 47/627 (7%)
Query: 15 MFLLLKFSKAIEIP------SSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTF 67
+ LL AIEIP + + Q PTI KQS K + P D IECEAKGNP P+F
Sbjct: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSF 73
Query: 68 SWTKDGNPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIE 124
WT++ F D R+ SGT I + G ++G+Y+CFA NK G A+S I
Sbjct: 74 HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIR 133
Query: 125 FIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQ 184
V P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV
Sbjct: 134 LQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH 193
Query: 185 KGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKAN 244
GDLYF+NV +D + DY C A F TI QK P L V + +
Sbjct: 194 NGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR---------------- 237
Query: 245 SIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETK 304
+ +R P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP +
Sbjct: 238 GVAERTPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKF 294
Query: 305 ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNG 364
EN+ K L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G
Sbjct: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354
Query: 365 ILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCE 418
L+C A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC
Sbjct: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCN 409
Query: 419 ASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEE 478
SN HG +LANA + V+DV P + + + ++ L C FF SP + W K +
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 469
Query: 479 VKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPK 538
L+G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P+
Sbjct: 470 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529
Query: 539 NPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVT 598
+ + ++L C K D LK L +SW KD E I R+ + +LTI V
Sbjct: 530 DQVARRGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIG----NRMKKEDDSLTIFGVA 583
Query: 599 LEDQGIYCCSAHTALDSAADITQVTVL 625
DQG Y C A T LD +TVL
Sbjct: 584 ERDQGSYTCVASTELDQDLAKAYLTVL 610
Score = 82.4 bits (202), Expect = 2e-15
Identities = 128/580 (22%), Positives = 208/580 (35%), Gaps = 93/580 (16%)
Query: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM-NIELEHIE 175
I M I+ + P K+ V+ D I++ C KG P +W N +I
Sbjct: 27 IPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEA-KGNPAPSFHWTRNSRFFNIA 85
Query: 176 QDERVYMSQKGDLYFANVEE----KDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHAN 231
+D RV M ++ + ++ +Y CFA
Sbjct: 86 KDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR------------------------ 121
Query: 232 DSSSSTEIGSK-ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAE-GLPTPQVD 289
+ G+ +N I+ + K L P E+ + + +G L L+C GLP+P +
Sbjct: 122 -----NKFGTALSNRIRLQVSKSPLWPKEN--LDPVVVQEGAPLTLQCNPPPGLPSPVIF 174
Query: 290 WNKIGGD-LPKGRETKENYGKTLKIENVSYQD-KGNYRCTASNFLGTATHDFHVIVEEPP 347
W + + + + + + L NV QD + +Y C A H H I ++ P
Sbjct: 175 WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR------FHFTHTIQQKNP 228
Query: 348 RWTKK---------------PQSAVYST----GSNGILLCEAEGEPQPTIKWRVNGS--P 386
K PQ S G + +L C A G P P I W G P
Sbjct: 229 FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 288
Query: 387 VDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDG 446
D F F + + TN+ + Y C ASN G+I ++ V + +
Sbjct: 289 SDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD--EP 343
Query: 447 ENYATVVGYSAFLHCEFFASPEAVVSW----QKVEEVKPLEGRRYHIYENGTLQINRTTE 502
+N G L C +P+ V W + ++ P R T+ T
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQI 400
Query: 503 EDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKH 562
Y C N G A + + + +SP+N I + L+ ++ D
Sbjct: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI----LYNRTRLDCPFFG 456
Query: 563 SL--KLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADIT 620
S L W K+G+ ++G + + +L I + EDQGIY C A L A +
Sbjct: 457 SPIPTLRWFKNGQGSNLDG--GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
Query: 621 QVTVLDVPDPPENLHLSERQ--NRSVRLTWEAGADHNSNI 658
+ L+V DP + E Q R + E H+ ++
Sbjct: 515 R---LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSL 551
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 395 bits (1014), Expect = e-109
Identities = 291/992 (29%), Positives = 458/992 (46%), Gaps = 90/992 (9%)
Query: 37 IIKQSKVQVAFP---FDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNN----S 89
+ + + V FP +E + C A+ +P T+ W +G T+ ++ P +
Sbjct: 38 VFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNG-----TEMKLEPGSRHQLVG 92
Query: 90 GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPI 149
G I N G Y+C ASN +G +S E + +F KE+ DP++ EG +
Sbjct: 93 GNLVIMNPTKAQD-AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGV 151
Query: 150 VLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQK-GDLYFANVEEKDSRNDYCCFAA 207
+LPCNPP P L W+ E + I D R ++SQ G+LY A D N Y C A
Sbjct: 152 MLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGN-YSCLA- 209
Query: 208 FPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSIT 267
T K + N ++ T + A SIK R P +
Sbjct: 210 -----TSHMDFSTKSVFSKFAQLNLAAEDTRLF--APSIKARFP------------AETY 250
Query: 268 ILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCT 327
L G+ + LECFA G P P++ W K+ G L T E TL+I +VS++D+G Y C
Sbjct: 251 ALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE---PTLQIPSVSFEDEGTYECE 307
Query: 328 ASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPV 387
A N G T +IV+ P W K GSN C A G+P+PT++W NG P+
Sbjct: 308 AENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL 367
Query: 388 DNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGE 447
+ V ++ F+ L + +YQC A N HGTI A+A + V + P +
Sbjct: 368 ASQNRVE--VLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVR 425
Query: 448 NYATVV-GYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAG 506
G + C+ A+P+AVV W K E+ + R + +GTL I + D G
Sbjct: 426 RLIPAARGGEILIPCQPRAAPKAVVLWSKGTEIL-VNSSRVTVTPDGTLIIRNISRSDEG 484
Query: 507 SYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKL 566
Y+C+ EN +GK T L +R+ATK+ ++P + I L L C + D + L
Sbjct: 485 KYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTM--DLTF 542
Query: 567 SWSKDGEAFEINGTEDG------RIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADIT 620
+W+ D F I+ + G + +LTI N L G Y C A T +DSA+
Sbjct: 543 TWTLDD--FPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEA 600
Query: 621 QVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEEL-- 678
V V P PP + + + + +++L+W G D++S I++Y ++ G+W+++
Sbjct: 601 TVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQ--ARTPPAGKWKQVRT 658
Query: 679 --TRVQGK-KTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIR 735
++G +T +L L P++ Y+FRVIA N +G +PS PS T AAP P +
Sbjct: 659 NPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLS 718
Query: 736 VQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVM-----T 790
P E+I+ W P+ QNG G Y ++++ QG+ W+ V + +
Sbjct: 719 GGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGS-THWQTARVPGADAQYFVYSNES 777
Query: 791 PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVP 850
Y P++VK+++ N+ G GP+ + +YS E+ P AP ++S+ + VTW V
Sbjct: 778 VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ 837
Query: 851 KDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910
+D ++G L GY+I +WK + +R +G S V L +++H+TV A
Sbjct: 838 QD-MNGILLGYEIRYWKAGD------KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRA 890
Query: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWG--LPKKLNGNLTGYLLQ 968
YN G GP S T + P +P + ++ W +P + +TGY +
Sbjct: 891 YNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKML 950
Query: 969 YQIINDTYEIGELNDINITTPSKPSWHLSNLN 1000
YQ ND+++T P+ HL+ N
Sbjct: 951 YQ-----------NDLHLT----PTLHLTGKN 967
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 375 bits (962), Expect = e-103
Identities = 279/1015 (27%), Positives = 458/1015 (45%), Gaps = 84/1015 (8%)
Query: 33 QVPTIIKQSKVQVAFPF---DEYFQIECEAKGNPEPTFSWTKDGNPFYFT-DHRIIPSNN 88
Q P IK+ + FP D+ + CEA+GNP P + W +G+ + +HR N
Sbjct: 24 QGPVFIKEPSNSI-FPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRY--KLN 80
Query: 89 SGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDP 148
G + N + G Y+CFA+N LG +S E + + F + + V EG
Sbjct: 81 GGNLVVINPNR-NWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQG 139
Query: 149 IVLPCNPPKGLPPLHIYWMNIEL-EHIEQDERVYMSQK-GDLYFANVEEKDSRNDYCCFA 206
+VL C PP L W+ E +E+D R ++SQ+ G LY + VE D N C
Sbjct: 140 VVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTC--- 196
Query: 207 AFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIK-QRKPKLLLPPTESGSESS 265
+ + + +A S T + +++ + + +PK+ E +
Sbjct: 197 ---------------VVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKI-----EVQFPET 236
Query: 266 ITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETK-ENYGKTLKIENVSYQDKGNY 324
+ KG + LECFA G P PQ++W + G LP + K + L+I N +D G+Y
Sbjct: 237 LPAAKGSTVKLECFALGNPIPQINWRRSDG-LPFSSKIKLRKFSGVLEIPNFQQEDAGSY 295
Query: 325 RCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNG 384
C A N G + P W + + + + C A G+P+P+ +W NG
Sbjct: 296 ECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNG 355
Query: 385 SPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTK 444
+ + + ++ +NL + ++QC A N HG + ++A + VV P
Sbjct: 356 AALVLEERTQ--IENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKN 413
Query: 445 DGENYATV-VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEE 503
+ V VG L C+ ASP A+ SW+K +V E R + +G L+I T+
Sbjct: 414 PMKKLVQVQVGSLVSLDCKPRASPRALSSWKK-GDVSVQEHERISLLNDGGLKIANVTKA 472
Query: 504 DAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLK-- 561
DAG+Y+C EN GK T +L + T++ ++P N + + L C+ + D L
Sbjct: 473 DAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDII 532
Query: 562 -----HSLKLSWSKDGEAFE-INGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDS 615
+ + KDG FE + G+ G +L I N+ L+ G Y C T +DS
Sbjct: 533 FTWYFNGALADFKKDGSHFEKVGGSSSG-------DLMIRNIQLKHSGKYVCMVQTGVDS 585
Query: 616 AADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRW 675
+ + V P PPEN+ + E + + +L+W+ G D++S + Y ++ W
Sbjct: 586 VSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQ--ARTPFSVGW 643
Query: 676 EELTRV----QGKK-TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRN 730
+ +T V GK T ++ L P+V Y+FRV+A N++G +PS PS+ T A P+
Sbjct: 644 QTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVP 703
Query: 731 PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN-----HT 785
P + E++I W+P+ QNG G Y V ++P G W + VT+ +
Sbjct: 704 PSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGV-TTWIQTVVTSPDTPRYV 762
Query: 786 LRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVT 845
R + Y+PY+VKV N G GP T++S E+ P AP + ++S+ ++V+
Sbjct: 763 FRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVS 822
Query: 846 WSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFH 905
W+T+P +G L GY++ +W +G + + ++ +G S + L + ++
Sbjct: 823 WNTIPWKLSNGHLLGYEVRYW------NGGGKEESSSKMKVAGNETSARLRGLKSNLAYY 876
Query: 906 LTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKL--NGNLT 963
V AYNS GAGP S T + P QP V L+W K + +T
Sbjct: 877 TAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVT 936
Query: 964 GYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCG 1018
GY + Y+ + N++ + +K S L L Y ++A T G G
Sbjct: 937 GYKVFYRTSSQ-------NNVQVLNTNKTSAELV-LPIKEDYIIEVKATTDGGDG 983
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 356 bits (913), Expect = 9e-98
Identities = 267/962 (27%), Positives = 414/962 (43%), Gaps = 75/962 (7%)
Query: 37 IIKQSKVQVAFPFD---EYFQIECEAKGNPEPTFSWTKDGNPFYF-TDHRIIPSNNSGTF 92
I Q V FP D + ++ CE KGNP+P W +G D R S
Sbjct: 27 IFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLI 86
Query: 93 RIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLP 152
PN+ + G Y+C A+N G +S E + + F + V G +VL
Sbjct: 87 NNPNK---TQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLL 143
Query: 153 CNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLR 212
C PP L W+ E + + R + G+LY A VE+ D N Y C
Sbjct: 144 CGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGN-YTCVVTNTVTN 202
Query: 213 TIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGE 272
V P L + ND + + +PK+ E ++ KG
Sbjct: 203 HKVLGPPTPLILR-----ND-----------GVMGEYEPKI-----EVQFPETVPTAKGA 241
Query: 273 ILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFL 332
+ LECFA G P P + W + G + + L+I N +D G Y C A N
Sbjct: 242 TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSR 301
Query: 333 GTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPF 392
G + P W +K + N C+A G P+PT KW NG P+
Sbjct: 302 GKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDR 361
Query: 393 AGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATV 452
I+ NL + +YQC A N HG I +NA + V+ V P + V
Sbjct: 362 IQIEQGTLNITIVNL--SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLV 419
Query: 453 -VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCW 511
VG + C+ ASP+ V +W+K ++ E R I E+G L+I T+ DAGSY+C
Sbjct: 420 KVGGEVVIECKPKASPKPVYTWKKGRDILK-ENERITISEDGNLRIINVTKSDAGSYTCI 478
Query: 512 VENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWS-- 569
N G + T NL +++ T++ V P + + + L C+ D L + +WS
Sbjct: 479 ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL--DIVFTWSFN 536
Query: 570 -------KDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQV 622
+DG+ FE G +D +L I N+ L+ G Y C T++D + +
Sbjct: 537 GHLIDFDRDGDHFERVGGQD-----SAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADL 591
Query: 623 TVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVE----FEGNKEEPGRWEEL 678
V P PPE + + E + + +L+W G D++S I+ Y+++ F + EL
Sbjct: 592 IVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPEL 651
Query: 679 TRVQGKK-TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQ 737
+ GK T ++ L P+V Y+FR +A N +G +PS+PS+ T A P+ P N+
Sbjct: 652 --IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGG 709
Query: 738 ASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEW-----EEETVTNHTLRVMTPA 792
E++I WE + QNG G Y V ++P G + W + + R +
Sbjct: 710 GGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMI-WMLTVLASADASRYVFRNESVH 768
Query: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
++P++VKV N G GP + +YS E+ P P +++T ++V W++ P +
Sbjct: 769 PFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLE 827
Query: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKEVNI--LRFSGQRNSGMVPSLDAFSEFHLTVLA 910
+ GR++GY++ +W R KE N +R G + S + +L +HL V A
Sbjct: 828 KNRGRIQGYEVKYW--------RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKA 879
Query: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLN--GNLTGYLLQ 968
YNS G GP S T + P QP + L+W K L+ + GY +
Sbjct: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVL 939
Query: 969 YQ 970
Y+
Sbjct: 940 YR 941
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 355 bits (911), Expect = 1e-97
Identities = 264/957 (27%), Positives = 425/957 (44%), Gaps = 63/957 (6%)
Query: 37 IIKQSKVQVAFPFD---EYFQIECEAKGNPEPTFSWTKDGNPFYFT---DHRIIPSNNSG 90
I Q V FP D + C A G P P + W ++G FT +R+ + G
Sbjct: 27 IFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRL----DGG 82
Query: 91 TFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIV 150
+ I N H G Y+C A+N LG +S + + + F + + V EG +V
Sbjct: 83 SLAI-NSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVV 141
Query: 151 LPCNPPKGLPPLHIYW-MNIELEHIEQDERVYMSQK-GDLYFANVEEKDSRNDYCCFAAF 208
L C PP L W N ++++D R ++SQ+ G+LY A VE D N Y CF
Sbjct: 142 LLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGN-YTCFITN 200
Query: 209 PRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITI 268
+ VQ P L + +G I+ R P+ + ++ +SS+
Sbjct: 201 KEAQRSVQGPPTPLV---------QRTDGVMGEYEPKIEVRFPETI----QAAKDSSVK- 246
Query: 269 LKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTA 328
LECFA G P P + W ++ G G+ L+I N +D+G Y C A
Sbjct: 247 -------LECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIA 299
Query: 329 SNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVD 388
SN G +I PP W +K Q+ S N + C+A G+P P W NG +
Sbjct: 300 SNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERL- 358
Query: 389 NHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGEN 448
+P + + T L + + VYQC A N + I ANA + V+ P +
Sbjct: 359 -NPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKK 417
Query: 449 YATV-VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGS 507
+ V VG + C+ A P A +SW++ E + +R + E+G+L+I T DAGS
Sbjct: 418 KSFVQVGGDIVIGCKPNAFPRAAISWKRGTETL-RQSKRIFLLEDGSLKIYNITRSDAGS 476
Query: 508 YSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLS 567
Y+C N G T +L ++ T + V P + + L C+ D ++ +
Sbjct: 477 YTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIE--VVFV 534
Query: 568 WSKDGEAFEINGTEDGRIIIDG---ANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 624
W +G+ ++ I G +L I N+ L G Y C+ T L+S + + + V
Sbjct: 535 WFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIV 594
Query: 625 LDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVE----FEGNKEEPGRWEELTR 680
P PPE++ + + + + +L+W AG D+NS I + ++ F + E+
Sbjct: 595 RGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILN 654
Query: 681 VQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ 740
+ TV+ L+P+V Y+FRV+A N +G +PS+PS+ T + P P NI
Sbjct: 655 GKTYNATVV-GLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGS 713
Query: 741 PKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN-----HTLRVMTPAVYA 795
E++I WE + QNG G Y + ++P G+ W +E V++ R + +
Sbjct: 714 RSELVITWESIPEELQNGEGFGYIIMFRPVGS-TTWSKEKVSSVESSRFVYRNESIIPLS 772
Query: 796 PYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVH 855
P++VKV N G G +YSGED P AP + +++ ++V+W+ + +R
Sbjct: 773 PFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNT 832
Query: 856 GRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKG 915
GR+ GY++ +W S + +R SG + + L A + + +V AYN+ G
Sbjct: 833 GRVLGYEVLYWTDDS------KESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAG 886
Query: 916 AGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKL--NGNLTGYLLQYQ 970
GP S P T + P QP K+ L+W K + + GY + Y+
Sbjct: 887 TGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYR 943
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 348 bits (893), Expect = 2e-95
Identities = 268/1001 (26%), Positives = 436/1001 (43%), Gaps = 86/1001 (8%)
Query: 3 PLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFD---EYFQIECEA 59
P LG Y L S A + SV P +++ + FP D + + CE
Sbjct: 67 PSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPD-DIIFPTDSDEKKVALNCEV 125
Query: 60 KGNPEPTFSWTKDGNPFYF-TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIA 118
+GNP P++ W ++G +D+R S GTF I N G Y+C A+N +G
Sbjct: 126 RGNPVPSYRWLRNGTEIDLESDYRY--SLIDGTFIISNPSEAKD-SGHYQCLATNTVGSI 182
Query: 119 MSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIEL-EHIEQD 177
+S E + F + V EG +VL C+PP P + W+ E + +D
Sbjct: 183 LSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAED 242
Query: 178 ERVYMSQK-GDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSS 236
R ++SQ+ G+LY + V+ D + C L N++ +A S
Sbjct: 243 SRRFISQETGNLYISKVQTSDVGSYIC------------------LVKNTVTNARVLSPP 284
Query: 237 TEIGSKANSIK-QRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGG 295
T + + + + + +PK+ E ++T KG + +ECFA G P P + W K+ G
Sbjct: 285 TPLTLRNDGVMGEYEPKI-----EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNG 339
Query: 296 DLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQS 355
+P +++ L+I NV D G Y C A N G + + V P W +K
Sbjct: 340 YIPSKARLRKSQA-VLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLND 398
Query: 356 AVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVY 415
+GS C+A G+P+PT +W NG P+ P + + + N+ + +Y
Sbjct: 399 TQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS--PQSRVEMVNGVLMIHNVNQSDAGMY 456
Query: 416 QCEASNVHGTILANANIDVVDVRP----------LIQTKDGENYATVVGYSAFLHCEFFA 465
QC A N +G I A+A + ++ P +I TKD E + C+
Sbjct: 457 QCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE---------VVIECKPQG 507
Query: 466 SPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525
SP+ +SW+K + E +R I +G+L+I ++ D G Y C EN G + A+L
Sbjct: 508 SPKPTISWKKGDRAVR-ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASL 566
Query: 526 DIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA--FEINGT--E 581
++ T++ ++PK + + L+C++ D+ L + W+ G+ FE G E
Sbjct: 567 SVKEPTRIELTPKRTELTVGESIVLNCKAIHDASL--DVTFYWTLKGQPIDFEEEGGHFE 624
Query: 582 DGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQN 641
R A+L I N+ L G Y C T DS +D ++ V P PP + + E
Sbjct: 625 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITE 684
Query: 642 RSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQ-----GKKTTVILPLAPFV 696
+ L+W AD++S IS Y + W+ + V ++ + + L P+V
Sbjct: 685 STATLSWSPAADNHSPISSY--NLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWV 742
Query: 697 RYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQ 756
Y+FRV+A N +G PS PS T A P P N+ ++ + E++I WEP+ Q
Sbjct: 743 EYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQ 802
Query: 757 NGPGLEYRVTWKPQGAPVEWEEETVTN-----HTLRVMTPAVYAPYDVKVQAINQLGSGP 811
NG G Y V ++P G W+E+ VT+ R + P++VKV N G GP
Sbjct: 803 NGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGP 861
Query: 812 DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSL 871
Q V + S E P AP ++ + + V W + + GR +G+++ +WK
Sbjct: 862 FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQ 919
Query: 872 LDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGV 931
D ++ G + ++ L+ + +H TV AYN G GP S T +
Sbjct: 920 ED------TAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSP 973
Query: 932 PEQPTFLKVIKVDKDTATLSWG--LPKKLNGNLTGYLLQYQ 970
P Q + +L W +P + GY + Y+
Sbjct: 974 PSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYR 1014
Score = 120 bits (302), Expect = 6e-27
Identities = 186/810 (22%), Positives = 309/810 (38%), Gaps = 86/810 (10%)
Query: 262 SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK-----GRETKENYGKTLKIENV 316
+ S++++ +G+ ++L C + +P++ ++ + + P R L I V
Sbjct: 201 TRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 259
Query: 317 SYQDKGNYRCTASNFLGTAT-----------HDFHVIVEEPPRWTKKPQSAVYSTGSNGI 365
D G+Y C N + A +D + EP P + + G+
Sbjct: 260 QTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVK 319
Query: 366 LLCEAEGEPQPTIKW-RVNGS-PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
+ C A G P PTI W +VNG P V + N+Q + +Y+C A N
Sbjct: 320 MECFALGNPVPTITWMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAENSR 375
Query: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
G + V ++ + + G C+ P W K PL
Sbjct: 376 GKNSFRGQLQVYTYPHWVEKLNDTQLDS--GSPLRWECKATGKPRPTYRWLK--NGVPLS 431
Query: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI-RNATKLRVSPKNPRI 542
+ NG L I+ + DAG Y C EN G +A L I +A ++ I
Sbjct: 432 PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI 491
Query: 543 PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLED 601
E+ E K K ++ SW K A E+ RI I+ +L I N + D
Sbjct: 492 IVTKDQEVVIECKPQGSPKPTI--SWKKGDRAVR----ENKRIAILPDGSLRILNASKSD 545
Query: 602 QGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNR-----SVRLTWEAGADHNS 656
+G Y C SA I ++V + P + L+ ++ S+ L +A D +
Sbjct: 546 EGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKAIHDASL 601
Query: 657 NISEYI------VEFEGNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNE 707
+++ Y ++FE EE G +E + R Q +++ L RY RV
Sbjct: 602 DVTFYWTLKGQPIDFE---EEGGHFESI-RAQASSADLMIRNILLMHAGRYGCRV----- 652
Query: 708 VGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP----GLEY 763
++ SD E P P + V+ + W P + + + P L+
Sbjct: 653 --QTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSP--AADNHSPISSYNLQA 708
Query: 764 RVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSG-PDPQSVTLYS 820
R + V+ E +T M + + Y+ +V A N +G+G P S + +
Sbjct: 709 RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 768
Query: 821 GEDYPDTAPV-IHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPK 879
E P TAP + G LV + W V ++ +G GY + + +G K
Sbjct: 769 NEAVPKTAPTNVSGRSGRRHELV-IAWEPVSEEFQNGEGFGYIVAFRP-----NGTRGWK 822
Query: 880 EVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFL 938
E + + S+ + F + V YN+KG GP S+ + + EG P PT +
Sbjct: 823 EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDV 882
Query: 939 KVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LS 997
K V ++W K+ G G+ + Y + + E + T S+ L+
Sbjct: 883 KATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAE----TVKTRGNESFVILT 938
Query: 998 NLNATTKYKFYLRACTSQGCGKPITEESST 1027
L T Y F +RA G G P +E S+T
Sbjct: 939 GLEGNTLYHFTVRAYNGAGYGPPSSEVSAT 968
Score = 99.4 bits (246), Expect = 2e-20
Identities = 180/868 (20%), Positives = 317/868 (36%), Gaps = 127/868 (14%)
Query: 40 QSKVQVAFPFD------EYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93
+ K++V FPF ++EC A GNP PT +W K N + + R+ S
Sbjct: 299 EPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV-NGYIPSKARLRKSQ--AVLE 355
Query: 94 IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153
IPN G Y C A N G S + V + P + EK++ +++ G P+ C
Sbjct: 356 IPNVQLDD--AGIYECRAENSRG-KNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWEC 411
Query: 154 NPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRT 213
G P W+ + + RV M G L NV + D+ Y C A +
Sbjct: 412 KAT-GKPRPTYRWLKNGVP-LSPQSRVEMVN-GVLMIHNVNQSDA-GMYQCLAE-NKYGA 466
Query: 214 IVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEI 273
I +K+ ++ A N +K+ +I + K +
Sbjct: 467 IYASAELKILASAPTFA------------LNQLKK----------------TIIVTKDQE 498
Query: 274 LLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLG 333
+++EC +G P P + W K + + + +L+I N S D+G Y C N G
Sbjct: 499 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG 558
Query: 334 TATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA--EGEPQPTIKWRVNGSPVDNHP 391
+A + V+EP R P+ + G + +L C+A + T W + G P+D
Sbjct: 559 SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 618
Query: 392 FAGDVVFPR------EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD 445
G R ++ N+ H Y C ++ A + L++
Sbjct: 619 EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAEL-------LVRGPP 671
Query: 446 GENYATVVGYSAFLHCEFFASPEAVVSWQKV-EEVKPLEGRRYHIYENGTLQINRTTEED 504
G +V E A +SW + P+ Y++ + T +
Sbjct: 672 GPPGIVIV--------EEITESTATLSWSPAADNHSPISS--YNLQARSPFSLGWQTVKT 721
Query: 505 -------------AGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELH 551
A + WVE A +T R+ N +PK +
Sbjct: 722 VPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVS 781
Query: 552 CESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHT 611
S +H L ++W E F+ NG G I+ N T +++ + A
Sbjct: 782 GRSG----RRHELVIAWEPVSEEFQ-NGEGFGYIVAFRPNGTRG---WKEKMVTSSEASK 833
Query: 612 ALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNS---------NISEYI 662
+ + +T +V N ++ V + G + ++SE +
Sbjct: 834 FIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEIL 893
Query: 663 VEFEGNKEEPGR--------WEEL--------TRVQGKKTTVILP-LAPFVRYQFRVIAV 705
V ++ KE GR W+++ + +G ++ VIL L Y F V A
Sbjct: 894 VAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 953
Query: 706 NEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
N G PS T + P + P N+R + Q ++ + WEP+ + + Y+V
Sbjct: 954 NGAGYGPPSSEVSA-TTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKV 1011
Query: 766 TWKPQGAPVEWEEETVTNHTLRVMTPAVYA-PYDVKVQAINQLGSGPDPQSVTL--YSGE 822
++ +G + + L+ + P A Y ++V+A ++ G G + + YSG
Sbjct: 1012 FYRQEG---HSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGG 1068
Query: 823 DYPDTAPVIHGVDVINSTLVKVTWSTVP 850
+H + +S++ + +P
Sbjct: 1069 KITSAQSTLHSLSTSSSSVTLLLALMIP 1096
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 347 bits (890), Expect = 4e-95
Identities = 264/987 (26%), Positives = 434/987 (43%), Gaps = 86/987 (8%)
Query: 17 LLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFD---EYFQIECEAKGNPEPTFSWTKDG 73
L+L S + + SV P +++ + FP D + + CE +GNP P++ W ++G
Sbjct: 7 LMLFLSVTMCLSESVDYGPVFVQEPD-DIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
Query: 74 NPFYF-TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPK 132
+D+R S GTF I N G Y+C A+N +G +S E +
Sbjct: 66 TEIDLESDYRY--SLIDGTFIISNPSEAKD-SGHYQCLATNTVGSILSREATLQFAYLGN 122
Query: 133 FPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIEL-EHIEQDERVYMSQK-GDLYF 190
F + V EG +VL C+PP P + W+ E + +D R ++SQ+ G+LY
Sbjct: 123 FSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI 182
Query: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIK-QR 249
+ V+ D + C L N++ +A S T + + + + +
Sbjct: 183 SKVQTSDVGSYIC------------------LVKNTVTNARVLSPPTPLTLRNDGVMGEY 224
Query: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309
+PK+ E ++T KG + +ECFA G P P + W K+ G +P +++
Sbjct: 225 EPKI-----EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQA- 278
Query: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369
L+I NV D G Y C A N G + + V P W +K +GS C+
Sbjct: 279 VLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECK 338
Query: 370 AEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILAN 429
A G+P+PT +W NG P+ P + + + N+ + +YQC A N +G I A+
Sbjct: 339 ATGKPRPTYRWLKNGVPLS--PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS 396
Query: 430 ANIDVVDVRP----------LIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEV 479
A + ++ P +I TKD E + C+ SP+ +SW+K +
Sbjct: 397 AELKILASAPTFALNQLKKTIIVTKDQE---------VVIECKPQGSPKPTISWKKGDRA 447
Query: 480 KPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKN 539
E +R I +G+L+I ++ D G Y C EN G + A+L ++ T++ ++PK
Sbjct: 448 VR-ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR 506
Query: 540 PRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA--FEINGT--EDGRIIIDGANLTIS 595
+ + L+C++ D+ L + W+ G+ FE G E R A+L I
Sbjct: 507 TELTVGESIVLNCKAIHDASL--DVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIR 564
Query: 596 NVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHN 655
N+ L G Y C T DS +D ++ V P PP + + E + L+W AD++
Sbjct: 565 NILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNH 624
Query: 656 SNISEYIVEFEGNKEEPGRWEELTRVQ-----GKKTTVILPLAPFVRYQFRVIAVNEVGR 710
S IS Y + W+ + V ++ + + L P+V Y+FRV+A N +G
Sbjct: 625 SPISSY--NLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT 682
Query: 711 SQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQ 770
PS PS T A P P N+ ++ + E++I WEP+ QNG G Y V ++P
Sbjct: 683 GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPN 742
Query: 771 GAPVEWEEETVTN-----HTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYP 825
G W+E+ VT+ R + P++VKV N G GP Q V + S E P
Sbjct: 743 GTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEP 801
Query: 826 DTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILR 885
AP ++ + + V W + + GR +G+++ +WK D ++
Sbjct: 802 SAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQED------TAETVK 853
Query: 886 FSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDK 945
G + ++ L+ + +H TV AYN G GP S T + P Q +
Sbjct: 854 TRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG 913
Query: 946 DTATLSWG--LPKKLNGNLTGYLLQYQ 970
+L W +P + GY + Y+
Sbjct: 914 SQVSLGWEPVIPLANESEVVGYKVFYR 940
Score = 120 bits (302), Expect = 6e-27
Identities = 186/810 (22%), Positives = 309/810 (38%), Gaps = 86/810 (10%)
Query: 262 SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK-----GRETKENYGKTLKIENV 316
+ S++++ +G+ ++L C + +P++ ++ + + P R L I V
Sbjct: 127 TRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 185
Query: 317 SYQDKGNYRCTASNFLGTAT-----------HDFHVIVEEPPRWTKKPQSAVYSTGSNGI 365
D G+Y C N + A +D + EP P + + G+
Sbjct: 186 QTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVK 245
Query: 366 LLCEAEGEPQPTIKW-RVNGS-PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
+ C A G P PTI W +VNG P V + N+Q + +Y+C A N
Sbjct: 246 MECFALGNPVPTITWMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAENSR 301
Query: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
G + V ++ + + G C+ P W K PL
Sbjct: 302 GKNSFRGQLQVYTYPHWVEKLNDTQLDS--GSPLRWECKATGKPRPTYRWLK--NGVPLS 357
Query: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI-RNATKLRVSPKNPRI 542
+ NG L I+ + DAG Y C EN G +A L I +A ++ I
Sbjct: 358 PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI 417
Query: 543 PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLED 601
E+ E K K ++ SW K A E+ RI I+ +L I N + D
Sbjct: 418 IVTKDQEVVIECKPQGSPKPTI--SWKKGDRAVR----ENKRIAILPDGSLRILNASKSD 471
Query: 602 QGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNR-----SVRLTWEAGADHNS 656
+G Y C SA I ++V + P + L+ ++ S+ L +A D +
Sbjct: 472 EGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKAIHDASL 527
Query: 657 NISEYI------VEFEGNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNE 707
+++ Y ++FE EE G +E + R Q +++ L RY RV
Sbjct: 528 DVTFYWTLKGQPIDFE---EEGGHFESI-RAQASSADLMIRNILLMHAGRYGCRV----- 578
Query: 708 VGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP----GLEY 763
++ SD E P P + V+ + W P + + + P L+
Sbjct: 579 --QTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSP--AADNHSPISSYNLQA 634
Query: 764 RVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSG-PDPQSVTLYS 820
R + V+ E +T M + + Y+ +V A N +G+G P S + +
Sbjct: 635 RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 694
Query: 821 GEDYPDTAPV-IHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPK 879
E P TAP + G LV + W V ++ +G GY + + +G K
Sbjct: 695 NEAVPKTAPTNVSGRSGRRHELV-IAWEPVSEEFQNGEGFGYIVAFRP-----NGTRGWK 748
Query: 880 EVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFL 938
E + + S+ + F + V YN+KG GP S+ + + EG P PT +
Sbjct: 749 EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDV 808
Query: 939 KVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LS 997
K V ++W K+ G G+ + Y + + E + T S+ L+
Sbjct: 809 KATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAE----TVKTRGNESFVILT 864
Query: 998 NLNATTKYKFYLRACTSQGCGKPITEESST 1027
L T Y F +RA G G P +E S+T
Sbjct: 865 GLEGNTLYHFTVRAYNGAGYGPPSSEVSAT 894
Score = 99.4 bits (246), Expect = 2e-20
Identities = 180/868 (20%), Positives = 317/868 (36%), Gaps = 127/868 (14%)
Query: 40 QSKVQVAFPFD------EYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93
+ K++V FPF ++EC A GNP PT +W K N + + R+ S
Sbjct: 225 EPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV-NGYIPSKARLRKSQ--AVLE 281
Query: 94 IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153
IPN G Y C A N G S + V + P + EK++ +++ G P+ C
Sbjct: 282 IPNVQLDD--AGIYECRAENSRG-KNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWEC 337
Query: 154 NPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRT 213
G P W+ + + RV M G L NV + D+ Y C A +
Sbjct: 338 KAT-GKPRPTYRWLKNGVP-LSPQSRVEMVN-GVLMIHNVNQSDA-GMYQCLAE-NKYGA 392
Query: 214 IVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEI 273
I +K+ ++ A N +K+ +I + K +
Sbjct: 393 IYASAELKILASAPTFA------------LNQLKK----------------TIIVTKDQE 424
Query: 274 LLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLG 333
+++EC +G P P + W K + + + +L+I N S D+G Y C N G
Sbjct: 425 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG 484
Query: 334 TATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA--EGEPQPTIKWRVNGSPVDNHP 391
+A + V+EP R P+ + G + +L C+A + T W + G P+D
Sbjct: 485 SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 544
Query: 392 FAGDVVFPR------EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD 445
G R ++ N+ H Y C ++ A + L++
Sbjct: 545 EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAEL-------LVRGPP 597
Query: 446 GENYATVVGYSAFLHCEFFASPEAVVSWQKV-EEVKPLEGRRYHIYENGTLQINRTTEED 504
G +V E A +SW + P+ Y++ + T +
Sbjct: 598 GPPGIVIV--------EEITESTATLSWSPAADNHSPISS--YNLQARSPFSLGWQTVKT 647
Query: 505 -------------AGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELH 551
A + WVE A +T R+ N +PK +
Sbjct: 648 VPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVS 707
Query: 552 CESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHT 611
S +H L ++W E F+ NG G I+ N T +++ + A
Sbjct: 708 GRSG----RRHELVIAWEPVSEEFQ-NGEGFGYIVAFRPNGTRG---WKEKMVTSSEASK 759
Query: 612 ALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNS---------NISEYI 662
+ + +T +V N ++ V + G + ++SE +
Sbjct: 760 FIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEIL 819
Query: 663 VEFEGNKEEPGR--------WEEL--------TRVQGKKTTVILP-LAPFVRYQFRVIAV 705
V ++ KE GR W+++ + +G ++ VIL L Y F V A
Sbjct: 820 VAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 879
Query: 706 NEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
N G PS T + P + P N+R + Q ++ + WEP+ + + Y+V
Sbjct: 880 NGAGYGPPSSEVSA-TTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKV 937
Query: 766 TWKPQGAPVEWEEETVTNHTLRVMTPAVYA-PYDVKVQAINQLGSGPDPQSVTL--YSGE 822
++ +G + + L+ + P A Y ++V+A ++ G G + + YSG
Sbjct: 938 FYRQEG---HSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGG 994
Query: 823 DYPDTAPVIHGVDVINSTLVKVTWSTVP 850
+H + +S++ + +P
Sbjct: 995 KITSAQSTLHSLSTSSSSVTLLLALMIP 1022
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 344 bits (882), Expect = 3e-94
Identities = 267/962 (27%), Positives = 426/962 (44%), Gaps = 86/962 (8%)
Query: 37 IIKQSKVQVAFPFDEY---FQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93
I ++ + +P + + C A+ +P P + W + T R +
Sbjct: 42 IFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVIN 101
Query: 94 IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153
P++ + G Y C ASN G+ S E + FP E+ + V+EG +VL C
Sbjct: 102 NPDKQKDA---GIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 158
Query: 154 NPPKGLPP-LHIYWMNIELE-HIEQDERVYMSQ-KGDLYFANVEEKDSRNDYCCFAAFPR 210
+PP P L W+ E I D+R ++SQ G+LY ANVE D N Y CF + P
Sbjct: 159 DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGN-YSCFVSSPS 217
Query: 211 L-RTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITIL 269
+ +++ K + + T A+ + Q K + L
Sbjct: 218 ITKSVFSKFIPLIPI---------PERTTKPYPADIVVQFK--------------DVYAL 254
Query: 270 KGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTAS 329
G+ + LECFA G P P + W K+ +P E + G LKI N+ +D+G Y C A
Sbjct: 255 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTS-GAVLKIFNIQLEDEGIYECEAE 313
Query: 330 NFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDN 389
N G H + V+ P W + GS+ C A G+P PTI+W NG
Sbjct: 314 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG----- 368
Query: 390 HPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD-GEN 448
+ + + +++F N +YQC A N +G I ANA + ++ + P + +
Sbjct: 369 YAYHKGELRLYDVTFEN-----AGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKK 423
Query: 449 YATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSY 508
G + C+ A+P+ SW K E + R I+E+G+L+IN T D G Y
Sbjct: 424 ILAAKGGRVIIECKPKAAPKPKFSWSKGTEWL-VNSSRILIWEDGSLEINNITRNDGGIY 482
Query: 509 SCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSW 568
+C+ EN GK T L I + T++ ++P N I + C + D L L W
Sbjct: 483 TCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL--DLTFVW 540
Query: 569 SKDGEAFEINGT----EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 624
S +G + N + ++ L I N L+ G Y C+A T +D+++ + V
Sbjct: 541 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 600
Query: 625 LDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTR---- 680
P PP L + + + SV LTW G+D++S IS+Y ++ + + W++
Sbjct: 601 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDD--WKDAKTDPPI 658
Query: 681 VQGKKTTV-ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQAS 739
++G + L P++ Y+FRV+A N +GR +PS PS+ +T AAP+ P ++
Sbjct: 659 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 718
Query: 740 QPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN-------HTLRVMTPA 792
+ +E+ I W PL G Y V +KP EW++ TVTN H M+P+
Sbjct: 719 RNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKVTVTNPDTGRYVHKDETMSPS 777
Query: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
+ VKV+A N G GP + S +D P AP GV V++S+ + V W V +
Sbjct: 778 --TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK 835
Query: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKE--VNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910
V + YQI +W H KE N ++ + Q S + +L +++ + V A
Sbjct: 836 IV----ESYQIRYW--------AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGA 883
Query: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLN--GNLTGYLLQ 968
NS G GP S+ T + P QP + ++W L+ +TGY +
Sbjct: 884 CNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVL 943
Query: 969 YQ 970
Y+
Sbjct: 944 YR 945
Score = 126 bits (317), Expect = 1e-28
Identities = 211/948 (22%), Positives = 361/948 (38%), Gaps = 123/948 (12%)
Query: 114 KLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEH 173
+ G +SEE + P + P I P E EG + L C P++ + MN
Sbjct: 27 RYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGK-VSLNCRARASPFPVYKWRMNNGDVD 85
Query: 174 IEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDS 233
+ D Y G+L N +++ Y C A+ N+ +
Sbjct: 86 LTSDR--YSMVGGNLVINNPDKQKDAGIYYCLAS-----------------NNYGMVRST 126
Query: 234 SSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKI 293
++ G L P + + +G+ ++L C + + +
Sbjct: 127 EATLSFG-------------YLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWL 173
Query: 294 GGDLP------KGRETKENYGKTLKIENVSYQDKGNYRCTASN--FLGTATHDFHVIVEE 345
+ P K R + G L I NV DKGNY C S+ + F ++
Sbjct: 174 LNEFPVFITMDKRRFVSQTNGN-LYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPI 232
Query: 346 PPRWTKKPQSA--------VYST-GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDV 396
P R T KP A VY+ G N L C A G P P I+WR P+ P ++
Sbjct: 233 PER-TTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPM---PSTAEI 288
Query: 397 VFPREI-SFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQ-TKDGENYATVVG 454
+ N+Q +Y+CEA N+ G A I V ++ D E +G
Sbjct: 289 STSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE---VDIG 345
Query: 455 YSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVEN 514
+ C P + W K G YH G L++ T E+AG Y C EN
Sbjct: 346 SDLYWPCVATGKPIPTIRWLK-------NGYAYH---KGELRLYDVTFENAGMYQCIAEN 395
Query: 515 AIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLE-----LHCESKCDSHLKHSLKLSWS 569
G A+ AN +++ NP K+ + + C+ K K SWS
Sbjct: 396 TYG--AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP----KPKFSWS 449
Query: 570 KDGEAFEINGTEDGRIII-DGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLD-- 626
K G + +N + RI+I + +L I+N+T D GIY C A A + + D
Sbjct: 450 K-GTEWLVNSS---RILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPT 505
Query: 627 -VPDPPENLHLSERQNRSVRL--TWEAGADHNS--NISEYIVEFEGNKEEPGRWEELTRV 681
+ P N ++ +N +++ +++ D + + Y+++F NKE ++ +
Sbjct: 506 RIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF--NKENI-HYQRNFML 562
Query: 682 QGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQP 741
+I +++ R + S +D P P P +R++ +
Sbjct: 563 DSNGELLIRNAQ--LKHAGRYTCTAQTIVDNSSASADLVVRGPPGP---PGGLRIEDIRA 617
Query: 742 KEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETV-------TNHTLRVMTPAVY 794
+ + W + + + P +Y + K + +W++ R + +
Sbjct: 618 TSVALTWS--RGSDNHSPISKYTIQTKTILSD-DWKDAKTDPPIIEGNMEAARAVDLIPW 674
Query: 795 APYDVKVQAINQLGSG-PDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDR 853
Y+ +V A N LG G P S + + P+ AP G + + +TW+ + ++
Sbjct: 675 MEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREY 734
Query: 854 VHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNS 913
+G GY + + DG K+V + R ++ + F + V A+N+
Sbjct: 735 HYGNNFGYIVAF----KPFDGEEW-KKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNN 789
Query: 914 KGAGPESEPYIFQTPEGVP-EQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQII 972
KG GP S + + + P E PT + V + ++ W L + Y ++Y
Sbjct: 790 KGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEKIVESYQIRYWAA 847
Query: 973 NDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP 1020
+D E N + +T+ + S L NL T+Y + AC S GCG P
Sbjct: 848 HDKEEAA--NRVQVTS-QEYSARLENLLPDTQYFIEVGACNSAGCGPP 892
Score = 74.3 bits (181), Expect = 7e-13
Identities = 182/847 (21%), Positives = 288/847 (34%), Gaps = 142/847 (16%)
Query: 20 KFSKAIEIPS-SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYF 78
KF I IP + + P I V + +EC A GNP P W K P
Sbjct: 225 KFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 284
Query: 79 TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKI 138
T F I E +G Y C A N G + V + P++ E I
Sbjct: 285 TAEISTSGAVLKIFNIQLED-----EGIYECEAENIRG-KDKHQARIYVQAFPEWV-EHI 337
Query: 139 DPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDS 198
+ EV+ G + PC G P I W+ + + + R+Y D+ F N
Sbjct: 338 NDTEVDIGSDLYWPC-VATGKPIPTIRWLKNGYAYHKGELRLY-----DVTFENA----- 386
Query: 199 RNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPT 258
Y C A +T AN+ + K L P
Sbjct: 387 -GMYQCIA----------------------------ENTYGAIYANA--ELKILALAPTF 415
Query: 259 ESGS-ESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVS 317
E + I KG +++EC + P P+ W+K L +L+I N++
Sbjct: 416 EMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNIT 475
Query: 318 YQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEP--Q 375
D G Y C A N G A +++ +P R P +A + G N + C A +P
Sbjct: 476 RNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALD 535
Query: 376 PTIKWRVNGSPVD----NHPFAGDVVFPR--EISFTNLQPNHTAVYQCEASNVHGTILAN 429
T W NG +D N + + + E+ N Q H Y C A + ++
Sbjct: 536 LTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDN--SS 593
Query: 430 ANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI 489
A+ D+V P G L E + ++W + + +
Sbjct: 594 ASADLVVRGP-------------PGPPGGLRIEDIRATSVALTWSRGSD-------NHSP 633
Query: 490 YENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKL--------RVSPKN-- 539
T+Q +D W + + N++ A L RV N
Sbjct: 634 ISKYTIQTKTILSDD------WKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTL 687
Query: 540 ----PRIPKLHM-LELHCESKCDSHL------KHSLKLSWSKDGEAFEINGTEDGRII-- 586
P IP + + + S + L ++W+ + G G I+
Sbjct: 688 GRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHY-GNNFGYIVAF 746
Query: 587 --IDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP-DPPENLH--LSERQN 641
DG VT D G Y T S A +V + D P +L ++ Q+
Sbjct: 747 KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQD 806
Query: 642 RSVRLTWEAGAD---------HNSNISEYIVEF-------EGNKEEPGRWEELTRVQGKK 685
E G H ++ E IVE +KEE ++T +
Sbjct: 807 APSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQE--Y 864
Query: 686 TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH--ETPPAAPDRNPQNIRVQASQPKE 743
+ + L P +Y V A N G PS + + PP+ P R ++R
Sbjct: 865 SARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVR----SGSR 920
Query: 744 MIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQA 803
II W+ + ++ Y+V ++P G + + + H++ V P Y V+V+A
Sbjct: 921 YIITWDHVVALSNESTVTGYKVLYRPDGQH-DGKLYSTHKHSIEVPIPR-DGEYVVEVRA 978
Query: 804 INQLGSG 810
+ G G
Sbjct: 979 HSDGGDG 985
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 344 bits (882), Expect = 3e-94
Identities = 267/962 (27%), Positives = 426/962 (44%), Gaps = 86/962 (8%)
Query: 37 IIKQSKVQVAFPFDEY---FQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93
I ++ + +P + + C A+ +P P + W + T R +
Sbjct: 31 IFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVIN 90
Query: 94 IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153
P++ + G Y C ASN G+ S E + FP E+ + V+EG +VL C
Sbjct: 91 NPDKQKDA---GIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 147
Query: 154 NPPKGLPP-LHIYWMNIELE-HIEQDERVYMSQ-KGDLYFANVEEKDSRNDYCCFAAFPR 210
+PP P L W+ E I D+R ++SQ G+LY ANVE D N Y CF + P
Sbjct: 148 DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGN-YSCFVSSPS 206
Query: 211 L-RTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITIL 269
+ +++ K + + T A+ + Q K + L
Sbjct: 207 ITKSVFSKFIPLIPI---------PERTTKPYPADIVVQFK--------------DVYAL 243
Query: 270 KGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTAS 329
G+ + LECFA G P P + W K+ +P E + G LKI N+ +D+G Y C A
Sbjct: 244 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTS-GAVLKIFNIQLEDEGIYECEAE 302
Query: 330 NFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDN 389
N G H + V+ P W + GS+ C A G+P PTI+W NG
Sbjct: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG----- 357
Query: 390 HPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD-GEN 448
+ + + +++F N +YQC A N +G I ANA + ++ + P + +
Sbjct: 358 YAYHKGELRLYDVTFEN-----AGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKK 412
Query: 449 YATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSY 508
G + C+ A+P+ SW K E + R I+E+G+L+IN T D G Y
Sbjct: 413 ILAAKGGRVIIECKPKAAPKPKFSWSKGTEWL-VNSSRILIWEDGSLEINNITRNDGGIY 471
Query: 509 SCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSW 568
+C+ EN GK T L I + T++ ++P N I + C + D L L W
Sbjct: 472 TCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL--DLTFVW 529
Query: 569 SKDGEAFEINGT----EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 624
S +G + N + ++ L I N L+ G Y C+A T +D+++ + V
Sbjct: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 589
Query: 625 LDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTR---- 680
P PP L + + + SV LTW G+D++S IS+Y ++ + + W++
Sbjct: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDD--WKDAKTDPPI 647
Query: 681 VQGKKTTV-ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQAS 739
++G + L P++ Y+FRV+A N +GR +PS PS+ +T AAP+ P ++
Sbjct: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 707
Query: 740 QPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN-------HTLRVMTPA 792
+ +E+ I W PL G Y V +KP EW++ TVTN H M+P+
Sbjct: 708 RNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKVTVTNPDTGRYVHKDETMSPS 766
Query: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
+ VKV+A N G GP + S +D P AP GV V++S+ + V W V +
Sbjct: 767 --TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK 824
Query: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKE--VNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910
V + YQI +W H KE N ++ + Q S + +L +++ + V A
Sbjct: 825 IV----ESYQIRYW--------AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGA 872
Query: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLN--GNLTGYLLQ 968
NS G GP S+ T + P QP + ++W L+ +TGY +
Sbjct: 873 CNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVL 932
Query: 969 YQ 970
Y+
Sbjct: 933 YR 934
Score = 127 bits (319), Expect = 6e-29
Identities = 211/945 (22%), Positives = 361/945 (38%), Gaps = 123/945 (13%)
Query: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQ 176
+A+SEE + P + P I P E EG + L C P++ + MN +
Sbjct: 19 LAVSEEDKGFGPIFEEQPINTIYPEESLEGK-VSLNCRARASPFPVYKWRMNNGDVDLTS 77
Query: 177 DERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSS 236
D Y G+L N +++ Y C A+ N+ + ++
Sbjct: 78 DR--YSMVGGNLVINNPDKQKDAGIYYCLAS-----------------NNYGMVRSTEAT 118
Query: 237 TEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGD 296
G L P + + +G+ ++L C + + + +
Sbjct: 119 LSFG-------------YLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNE 165
Query: 297 LP------KGRETKENYGKTLKIENVSYQDKGNYRCTASN--FLGTATHDFHVIVEEPPR 348
P K R + G L I NV DKGNY C S+ + F ++ P R
Sbjct: 166 FPVFITMDKRRFVSQTNGN-LYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
Query: 349 WTKKPQSA--------VYST-GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFP 399
T KP A VY+ G N L C A G P P I+WR P+ P ++
Sbjct: 225 -TTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPM---PSTAEISTS 280
Query: 400 REI-SFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQ-TKDGENYATVVGYSA 457
+ N+Q +Y+CEA N+ G A I V ++ D E +G
Sbjct: 281 GAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE---VDIGSDL 337
Query: 458 FLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIG 517
+ C P + W K G YH G L++ T E+AG Y C EN G
Sbjct: 338 YWPCVATGKPIPTIRWLK-------NGYAYH---KGELRLYDVTFENAGMYQCIAENTYG 387
Query: 518 KTAVTANLDIRNATKLRVSPKNPRIPKLHMLE-----LHCESKCDSHLKHSLKLSWSKDG 572
A+ AN +++ NP K+ + + C+ K K SWSK G
Sbjct: 388 --AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP----KPKFSWSK-G 440
Query: 573 EAFEINGTEDGRIII-DGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLD---VP 628
+ +N + RI+I + +L I+N+T D GIY C A A + + D +
Sbjct: 441 TEWLVNSS---RILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII 497
Query: 629 DPPENLHLSERQNRSVRL--TWEAGADHNS--NISEYIVEFEGNKEEPGRWEELTRVQGK 684
P N ++ +N +++ +++ D + + Y+++F NKE ++ +
Sbjct: 498 LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF--NKENI-HYQRNFMLDSN 554
Query: 685 KTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEM 744
+I +++ R + S +D P P P +R++ + +
Sbjct: 555 GELLIRNAQ--LKHAGRYTCTAQTIVDNSSASADLVVRGPPGP---PGGLRIEDIRATSV 609
Query: 745 IIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETV-------TNHTLRVMTPAVYAPY 797
+ W + + + P +Y + K + +W++ R + + Y
Sbjct: 610 ALTWS--RGSDNHSPISKYTIQTKTILSD-DWKDAKTDPPIIEGNMEAARAVDLIPWMEY 666
Query: 798 DVKVQAINQLGSG-PDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHG 856
+ +V A N LG G P S + + P+ AP G + + +TW+ + ++ +G
Sbjct: 667 EFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYG 726
Query: 857 RLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGA 916
GY + + DG K+V + R ++ + F + V A+N+KG
Sbjct: 727 NNFGYIVAF----KPFDGEEW-KKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGD 781
Query: 917 GPESEPYIFQTPEGVP-EQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDT 975
GP S + + + P E PT + V + ++ W L + Y ++Y +D
Sbjct: 782 GPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEKIVESYQIRYWAAHDK 839
Query: 976 YEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP 1020
E N + +T+ + S L NL T+Y + AC S GCG P
Sbjct: 840 EEAA--NRVQVTS-QEYSARLENLLPDTQYFIEVGACNSAGCGPP 881
Score = 74.3 bits (181), Expect = 7e-13
Identities = 182/847 (21%), Positives = 288/847 (34%), Gaps = 142/847 (16%)
Query: 20 KFSKAIEIPS-SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYF 78
KF I IP + + P I V + +EC A GNP P W K P
Sbjct: 214 KFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
Query: 79 TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKI 138
T F I E +G Y C A N G + V + P++ E I
Sbjct: 274 TAEISTSGAVLKIFNIQLED-----EGIYECEAENIRG-KDKHQARIYVQAFPEWV-EHI 326
Query: 139 DPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDS 198
+ EV+ G + PC G P I W+ + + + R+Y D+ F N
Sbjct: 327 NDTEVDIGSDLYWPC-VATGKPIPTIRWLKNGYAYHKGELRLY-----DVTFENA----- 375
Query: 199 RNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPT 258
Y C A +T AN+ + K L P
Sbjct: 376 -GMYQCIA----------------------------ENTYGAIYANA--ELKILALAPTF 404
Query: 259 ESGS-ESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVS 317
E + I KG +++EC + P P+ W+K L +L+I N++
Sbjct: 405 EMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNIT 464
Query: 318 YQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEP--Q 375
D G Y C A N G A +++ +P R P +A + G N + C A +P
Sbjct: 465 RNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALD 524
Query: 376 PTIKWRVNGSPVD----NHPFAGDVVFPR--EISFTNLQPNHTAVYQCEASNVHGTILAN 429
T W NG +D N + + + E+ N Q H Y C A + ++
Sbjct: 525 LTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDN--SS 582
Query: 430 ANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI 489
A+ D+V P G L E + ++W + + +
Sbjct: 583 ASADLVVRGP-------------PGPPGGLRIEDIRATSVALTWSRGSD-------NHSP 622
Query: 490 YENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKL--------RVSPKN-- 539
T+Q +D W + + N++ A L RV N
Sbjct: 623 ISKYTIQTKTILSDD------WKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTL 676
Query: 540 ----PRIPKLHM-LELHCESKCDSHL------KHSLKLSWSKDGEAFEINGTEDGRII-- 586
P IP + + + S + L ++W+ + G G I+
Sbjct: 677 GRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHY-GNNFGYIVAF 735
Query: 587 --IDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP-DPPENLH--LSERQN 641
DG VT D G Y T S A +V + D P +L ++ Q+
Sbjct: 736 KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQD 795
Query: 642 RSVRLTWEAGAD---------HNSNISEYIVEF-------EGNKEEPGRWEELTRVQGKK 685
E G H ++ E IVE +KEE ++T +
Sbjct: 796 APSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQE--Y 853
Query: 686 TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH--ETPPAAPDRNPQNIRVQASQPKE 743
+ + L P +Y V A N G PS + + PP+ P R ++R
Sbjct: 854 SARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVR----SGSR 909
Query: 744 MIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQA 803
II W+ + ++ Y+V ++P G + + + H++ V P Y V+V+A
Sbjct: 910 YIITWDHVVALSNESTVTGYKVLYRPDGQH-DGKLYSTHKHSIEVPIPR-DGEYVVEVRA 967
Query: 804 INQLGSG 810
+ G G
Sbjct: 968 HSDGGDG 974
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 284 bits (726), Expect = 4e-76
Identities = 253/1004 (25%), Positives = 440/1004 (43%), Gaps = 90/1004 (8%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
+ C A+G+ F W +D D + ++ + IP+ + G YRC N+
Sbjct: 124 LTCLAEGSWPLEFKWMRD-------DSELTTYSSEYKYIIPSLQKLD--AGFYRCVVRNR 174
Query: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHI 174
+G + + E V + F + V +G +L P P + W E I
Sbjct: 175 MGALLQRKSEVQVAYMGSF-MDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFR-EGHKI 232
Query: 175 EQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSS 234
R+ ++ + L D+ Y VQ + K N S
Sbjct: 233 IPSNRIAITLENQLVILATTTSDAGAYY------------VQAVNEKNGENKTSPFIHLS 280
Query: 235 SSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQ--VDWNK 292
+ ++G+ + P +++PP G+ S + LEC A P V W +
Sbjct: 281 IARDVGTP----ETMAPTIVVPP---GNRS--VVAGSSETTLECIASARPVEDLSVTWKR 331
Query: 293 IGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTAS---NFLGTATHDFHVIVEEPPRW 349
G + G + +G+ L I N + D G Y C A+ + A + + EPP +
Sbjct: 332 NGVRITSGLHS---FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYF 388
Query: 350 TKKPQSAVYSTGSNGILL-CEAEGEPQPTIKW---RVNGSPVDNHPFAGDVVFPREISFT 405
T +P+S + + + + C+A G P PT++W ++ S + N + V+ +
Sbjct: 389 TAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYK--VLASGGLRIQ 446
Query: 406 NLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFA 465
L+P + ++QC ASN G I + +DV ++ P+ + + T G +A L CE
Sbjct: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD-GMTAILRCEVSG 505
Query: 466 SPEAVVSWQKVEEVKP---LEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVT 522
+P+ ++W++ + + R+ + E+G LQI +DAG+Y+C+ N G +
Sbjct: 506 APKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNAS 565
Query: 523 ANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTED 582
A L + N T + P++ + K LHC + D + SL+ W KD A + T
Sbjct: 566 ATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRV--SLRYVWKKDNVALTPSSTS- 622
Query: 583 GRIIID-GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQN 641
RI+++ +L IS D G Y C + + + + ++ V+++P P+NL +S +
Sbjct: 623 -RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSS 681
Query: 642 RS--VRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE-ELTRVQGKKTTVILP-LAPFVR 697
S V L+W D NS I YIVE N W+ L+ V + T V + L P
Sbjct: 682 HSHAVVLSWVRPFDGNSPILYYIVELSENNSP---WKVHLSNVGPEMTGVTVSGLTPART 738
Query: 698 YQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQN 757
YQFRV AVNEVGR Q S + P P P+NI + ++++W+P E N
Sbjct: 739 YQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHN 798
Query: 758 GPGLEYRVTWKPQGAPVEWEEETVTNHTLR---VMTPAVYAPYDVKVQAINQLGSGPDPQ 814
G Y + ++ G P E+++ +T+ + V ++ Y+++V A N G G +
Sbjct: 799 GVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSR 858
Query: 815 SVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDG 874
+VT Y+ + P P + +NST ++ W+ P+ ++G +GY++ W +
Sbjct: 859 AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADA---- 914
Query: 875 RTHPKEVNILR----FSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEG 930
P+ V ++ F G + G + +L F+ + +VL + + G GP S P + T E
Sbjct: 915 ---PEAVTVVTIAPDFHGVHH-GHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQED 970
Query: 931 VPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPS 990
P L ++ + +SW P + NG +TGY + ++E+ ND +T
Sbjct: 971 KPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQI-------SWEVYGRNDSRLTHTL 1023
Query: 991 KPSWH---LSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEG 1031
+ H + L++ T Y + A T+ G G SST+ G
Sbjct: 1024 NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSG 1064
Score = 142 bits (358), Expect = 2e-33
Identities = 136/540 (25%), Positives = 236/540 (43%), Gaps = 55/540 (10%)
Query: 560 LKHSLKLSWSKDGE----------AFEINGTEDGRIIIDGANLT-------ISNVTLEDQ 602
L SLK+SW + E ++E+ G D R+ + T +S++T
Sbjct: 984 LDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTI 1043
Query: 603 GIYCCSA-HTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEY 661
+ +A T L +++ I+ D+P P NL +S RS L + G D ++IS +
Sbjct: 1044 DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRW 1103
Query: 662 IVEFE----GNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNEVGRSQPS 714
IVE + G++EE W L + + +L L P+ Y+FR+ VN VG S S
Sbjct: 1104 IVEGQVGAIGDEEE---WVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS 1160
Query: 715 QPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--PGLEYRVTWKPQGA 772
S +T A PD P ++ V+ + + ++W PL + NG + YR+ +
Sbjct: 1161 PSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL 1220
Query: 773 PVEWEEETVTNHTLRVMTPAV---YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829
+ V++ R T + Y++++QA N +G+GP + V + E P AP
Sbjct: 1221 QSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAP 1280
Query: 830 VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889
+ ++ST + +TW++VP+ +G + GY+I ++ K L P+ + +
Sbjct: 1281 ENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKI-LFRAKDL-----DPEPRSHIVRGNH 1334
Query: 890 RNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQ-TPEGVPEQPTFLKVIKVDKDTA 948
S ++ L F + L VLA+ G G S P I + T + P P L +V +
Sbjct: 1335 TQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSV 1394
Query: 949 TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY 1008
+ W P++ NG + GY + Y++ + + ++ T + ++L + Y F
Sbjct: 1395 RIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATV---RQFTATDLAPESAYIFR 1451
Query: 1009 LRACTSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNW 1068
L A T QG G+P+ T + + P E+ P AE R + W
Sbjct: 1452 LSAKTRQGWGEPLEATVITTEKRER------------PAPPRELLVPQAEVTARSLRLQW 1499
Score = 126 bits (316), Expect = 1e-28
Identities = 99/416 (23%), Positives = 182/416 (43%), Gaps = 39/416 (9%)
Query: 628 PDPPENLHLSERQ--NRSVRLTWEAGADHNSNISEYIVEFEGNKEEP-GRWEELTRVQGK 684
P PP L + + + RS+RL W G+D S I + ++ +E P G W+ +
Sbjct: 1477 PAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV---RELPRGEWQTYSSSISH 1533
Query: 685 KTT--VILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPK 742
+ T V+ L PF Y+ R+ A N++G S S ++ T P P ++
Sbjct: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
Query: 743 EMIIKWEPLKSMEQNGPGLEYRVTW-------------KPQGAPVEWEEETVTNHTLRVM 789
++I+W+P + NG YR+ + K P+ E + + +
Sbjct: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
Query: 790 TPAV------------YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVI 837
+ Y Y+V + A N +G P V ++ GE P AP V +
Sbjct: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
Query: 838 NSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPS 897
++ ++VTW P + +G ++GY+I +W+ S T +V L R + +
Sbjct: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVR----LKN 1767
Query: 898 LDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKK 957
L + +++ +++ A+N+ G GP+S+P +T + P P+FL ++ T +SWG P
Sbjct: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
Query: 958 LNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACT 1013
NG L GY + Y+ + + ++ + + + + +L Y F ++A T
Sbjct: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART 1883
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/183 (25%), Positives = 75/183 (40%), Gaps = 22/183 (12%)
Query: 35 PTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG-------NPFYFTDHRIIPSN 87
P + + +++ +E I C+A G P PT W KD NP Y +++ S
Sbjct: 386 PYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY----KVLASG 441
Query: 88 NSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGD 147
++ E G ++CFASN+ G + + P F + +D V +G
Sbjct: 442 GLRIQKLRPED-----SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
Query: 148 PIVLPCNPPKGLPPLHIYWM---NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCC 204
+L C G P I W +I + R + + G L A V +D+ N Y C
Sbjct: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGN-YTC 553
Query: 205 FAA 207
+AA
Sbjct: 554 YAA 556
Score = 43.9 bits (102), Expect = 0.001
Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 7/115 (6%)
Query: 617 ADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE 676
A+IT P P ++ L + + L W G ++ + Y++E + E G W+
Sbjct: 1892 ANITAGPAEGSPGSPRDV-LVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDE--GLWD 1948
Query: 677 ----ELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
++ R T + L V Y+FRV+AVNE G +PS PS AP
Sbjct: 1949 MFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
Score = 38.1 bits (87), Expect = 0.052
Identities = 87/381 (22%), Positives = 132/381 (34%), Gaps = 44/381 (11%)
Query: 269 LKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLK--IENVSYQDKGNYRC 326
L+G L+L C AEG + W + +L Y K I ++ D G YRC
Sbjct: 117 LEGNRLVLTCLAEGSWPLEFKWMRDDSEL-------TTYSSEYKYIIPSLQKLDAGFYRC 169
Query: 327 TASNFLGT-ATHDFHVIVEEPPRWTKKPQSAVYSTGSNGIL-LCEAEGEPQPTIKW-RVN 383
N +G V V + Q S G IL L P+P + W R
Sbjct: 170 VVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREG 229
Query: 384 GSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASN-----------VHGTILANANI 432
+ ++ A + ++ + Y +A N +H +I +
Sbjct: 230 HKIIPSNRIA--ITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGT 287
Query: 433 DVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASP--EAVVSWQKVEEVKPLEGRRYHIY 490
+ P I G L C A P + V+W++ V+ G H +
Sbjct: 288 PET-MAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR-NGVRITSG--LHSF 343
Query: 491 ENGTLQINRTTEEDAGSYSCWVE---NAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHM 547
L I+ T D G Y C +A TA L I P++ RI
Sbjct: 344 -GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPES-RISA--E 399
Query: 548 LELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLEDQGIYC 606
+E + C + L W KD A I+ ++ R ++ L I + ED GI+
Sbjct: 400 VEETVDIGCQAMGVPLPTLQWYKD--AISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQ 457
Query: 607 CSAHTALDSAADITQVTVLDV 627
C A + +I T LDV
Sbjct: 458 CFAS---NEGGEIQTHTYLDV 475
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 270 bits (690), Expect = 6e-72
Identities = 244/953 (25%), Positives = 418/953 (43%), Gaps = 78/953 (8%)
Query: 105 GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHI 164
G YRC N++G + + E V + F +E V G+ V+ P +
Sbjct: 87 GFYRCIVRNRMGALLQRQTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145
Query: 165 YWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTV 224
W + I R+ ++ + L + D+ Y A + P+ LTV
Sbjct: 146 TWFR-DGRKIPPSSRIAITLENTLVILSTVAPDAGR-YYVQAVNDKNGDNKTSQPITLTV 203
Query: 225 NSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLP 284
+ +G A+ I P +++PP +S+ E+ L EC A P
Sbjct: 204 EN------------VGGPADPIA---PTIIIPP----KNTSVVAGTSEVTL-ECVANARP 243
Query: 285 TPQVD--WNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTA---SNFLGTATHDF 339
++ W K G L G ++ + L I N + D G Y C A S+ + +
Sbjct: 244 LIKLHIIWKKDGVLLSGGIS---DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA 300
Query: 340 HVIVEEPPRWTKKPQSAVYSTGSNGI-LLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVF 398
++ V EPP++ K+P+ + + + + C+A+G P P+I W + + V+ F
Sbjct: 301 YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR---F 357
Query: 399 PRE----ISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVG 454
+ + + L P+ T ++QC A N G + + + V + P I T+ + + G
Sbjct: 358 RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDG 416
Query: 455 YSAFLHCEFFASPEAVVSWQKVEEVKP---LEGRRYHIYENGTLQINRTTEEDAGSYSCW 511
S L CE +P ++WQK E + ++ R+ E+G+L I+ T DAG+Y+C
Sbjct: 417 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
Query: 512 VENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD 571
N+ G +A+L + T++ P++ + K + C D + +++ W KD
Sbjct: 477 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV--TIRYIWEKD 534
Query: 572 GEAFEINGTEDG-RIIID-GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPD 629
G GTE RI +D +L IS D G Y C +A + + + V +P
Sbjct: 535 GATL---GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPH 591
Query: 630 PPEN--LHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEEL-TRVQGKKT 686
PE+ LS + R++ LTW D NS + YI+E N W L V K T
Sbjct: 592 APEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP---WTVLLASVDPKAT 648
Query: 687 TVILP-LAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMI 745
+V + L P YQFR+ AVN+VG+ Q S+ ++ P P PQN+ + ++
Sbjct: 649 SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
Query: 746 IKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN---HTLRVMTPAVYAPYDVKVQ 802
I+W+P QNG Y + + G PV ++ + +T+ + L + ++ Y+++V
Sbjct: 709 IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
Query: 803 AINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQ 862
A N G G VT ++ + P P + NST ++ TW+ ++G +GY+
Sbjct: 769 AYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828
Query: 863 INWWKTKSLLDGRTHPKEVNIL----RFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGP 918
+ W+ + +EV ++ F + G V L F+E+ +VL + + G GP
Sbjct: 829 LIAWEPE-------QEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGP 881
Query: 919 ESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEI 978
S P + +T E VP L ++ + +SW P + NG LTGY + ++ N T
Sbjct: 882 RSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTR 941
Query: 979 GELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEG 1031
N+T + ++ L A T Y + A TS+G G+ +ST+ G
Sbjct: 942 VTHYLPNVTL----EYRVTGLTALTTYTIEVAAMTSKGQGQ---VSASTISSG 987
Score = 156 bits (395), Expect = 1e-37
Identities = 164/702 (23%), Positives = 285/702 (40%), Gaps = 133/702 (18%)
Query: 626 DVPDPPENLHLSER--QNRSVRLTWEAGADHNSNISEYIVEFEGNKEEP-GRW--EELTR 680
D P PP + + + RSV L+WE G+D S + Y ++ +E P GRW +
Sbjct: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQ---TRELPSGRWALHSASV 1454
Query: 681 VQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ 740
+ ++ L PF Y+FRV A N++G S+ S+ S+ T AAPD P + V
Sbjct: 1455 SHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT 1514
Query: 741 PKEMIIKWEPLKSMEQNGPGLEYRVTWKP--------------QGAPVEWEEETVTNHTL 786
++I+W+P + NG L +R+ ++ W E T
Sbjct: 1515 TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMR 1574
Query: 787 RVMTPAV----------YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP---VIHG 833
+ P++ + Y++++ N +G GP ++ GE P AP V+HG
Sbjct: 1575 NLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHG 1634
Query: 834 VDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSG 893
+T + VTW P D +G ++GY+I +W+ + + V L + NS
Sbjct: 1635 A---TATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR----GNLTERVKTLFLA--ENSV 1685
Query: 894 MVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWG 953
+ +L ++ + ++V A+N+ G GP S P QT + P P+ +K ++ + +SW
Sbjct: 1686 KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
Query: 954 LPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSW-HLSNLNATTKYKFYLRA- 1011
P+ NG L GY L Y+ + + ++ +++ S P W + +L Y+F +RA
Sbjct: 1746 APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNS-PLWLKVKDLAEGVTYRFRIRAK 1804
Query: 1012 ------------CTSQGCGKP-------ITEESSTL----GEGSKGIGKISGV------- 1041
T G G P I SS + G G G I+
Sbjct: 1805 TFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPS 1864
Query: 1042 --------------NLTQKTHPIEVFEPGAEHIVRLMTKN---WGDNDSIFQDVIETRGR 1084
++ T +++ +PG + R++ N +G S Q V +
Sbjct: 1865 DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKAN 1924
Query: 1085 EYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVK------EKEDLHPD 1138
+ Y+ + WF+ ++ + L+ +LLL + R + KY+ K K
Sbjct: 1925 PF---YE----EWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGH 1977
Query: 1139 PEIQSVKDETF--------------------GEYSDSDEKPLKGSLRSLNRDMQPTESAD 1178
E+ S+ + +F G Y+ S +P GSL + D+ T+ D
Sbjct: 1978 SEMMSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDV--TKYND 2035
Query: 1179 SLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATF 1220
+ + +E S I GS + V+SN +F
Sbjct: 2036 LI----PAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSF 2073
Score = 149 bits (377), Expect = 1e-35
Identities = 138/491 (28%), Positives = 215/491 (43%), Gaps = 43/491 (8%)
Query: 560 LKHSLKLSWSKDGEAFEINGTEDG-RIIIDGANLT-------ISNVTLEDQ--GIYCCSA 609
L SLK+SW + GE NG G RI + N T + NVTLE + G+ +
Sbjct: 907 LDTSLKVSWQEPGEK---NGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
Query: 610 HT-----------ALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNI 658
+T SA+ I+ ++P PP NL +S RSV L + G D ++I
Sbjct: 964 YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSI 1023
Query: 659 SEYIVEFE----GNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS 714
S ++VE + G EE +L+ ++ + L PF Y FR+ VN VG S PS
Sbjct: 1024 SRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPS 1083
Query: 715 QPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--PGLEYRVTWKPQGA 772
QPS +T A PD P N+ ++ + + ++W PL ME NG + Y++ +
Sbjct: 1084 QPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDG 1143
Query: 773 PVEWEEETVTNHTLRVMT---PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829
+ V + R T + Y V+VQA N +GSGP Q+V + E P + P
Sbjct: 1144 HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP 1203
Query: 830 VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889
S+ + V WS VP+ +G + GY++ + + S R E N R
Sbjct: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR---- 1259
Query: 890 RNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQ-TPEGVPEQPTFLKVIKVDKDTA 948
S + L + + + VLA+ G G S P I + T + VP P + +V +
Sbjct: 1260 --SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSV 1317
Query: 949 TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY 1008
L W P NG + Y + +++ T + + PS + + L + Y F
Sbjct: 1318 RLIWQPPAAPNGIILAYQITHRLNTTT---ANTATVEVLAPSARQYTATGLKPESVYLFR 1374
Query: 1009 LRACTSQGCGK 1019
+ A T +G G+
Sbjct: 1375 ITAQTRKGWGE 1385
Score = 65.9 bits (159), Expect = 2e-10
Identities = 81/306 (26%), Positives = 117/306 (38%), Gaps = 35/306 (11%)
Query: 350 TKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISF--TNL 407
T+ ++ V+ G+ +L C AEG KW N + F E + T+L
Sbjct: 30 TEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTK--------FSLEYRYMITSL 81
Query: 408 QPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVV-GYSAFLHCEFFAS 466
H Y+C N G +L V V + ++GE + +V G +A + AS
Sbjct: 82 DRTHAGFYRCIVRNRMGALLQRQT--EVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIAS 139
Query: 467 -PEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWV---ENAIGKTAVT 522
P+ V+W + P R EN TL I T DAG Y +N KT+
Sbjct: 140 FPQPQVTWFRDGRKIPPSSRIAITLEN-TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQP 198
Query: 523 ANLDIRN--------ATKLRVSPKNPR-IPKLHMLELHCESKCDSHLKHSLKLSWSKDGE 573
L + N A + + PKN + + L C + +K L + W KDG
Sbjct: 199 ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIK--LHIIWKKDGV 256
Query: 574 AFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPEN 633
G I LTI N T D G Y C A S + + L V +PP+
Sbjct: 257 LL------SGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQF 310
Query: 634 LHLSER 639
+ ER
Sbjct: 311 VKEPER 316
Score = 52.0 bits (123), Expect = 3e-06
Identities = 74/347 (21%), Positives = 121/347 (34%), Gaps = 48/347 (13%)
Query: 30 SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNS 89
SV + P +K+ + + ++ I C+AKG P P+ +W KD N
Sbjct: 303 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 362
Query: 90 GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPI 149
G +I G + G ++CFA N G + + P + +D V +G +
Sbjct: 363 GGLQI--SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-TVIDGMSV 419
Query: 150 VLPCNPPKGLPPLHIYWM---NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFA 206
VL C G P I W I Q R + G L + D+ Y C A
Sbjct: 420 VLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA-GTYTCLA 477
Query: 207 AFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSI 266
R D +S A+ + + ++ PP +
Sbjct: 478 TNSR-------------------GVDEAS-------ADLVVWARTRITKPPQDQ------ 505
Query: 267 TILKGEILLLECFAEGLP--TPQVDWNKIGGDLPKGRET----KENYGKTLKIENVSYQD 320
+++KG + C P T + W K G L G E+ + + +L I D
Sbjct: 506 SVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL--GTESHPRIRLDRNGSLHISQTWSGD 563
Query: 321 KGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILL 367
G Y C + G + H+ V + P + P + + + I L
Sbjct: 564 IGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINL 610
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 7/115 (6%)
Query: 617 ADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE 676
A++T P PP + + R + ++ + W +G I+ Y++E + E G W+
Sbjct: 1814 ANVTTGPGEGAPGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDE--GLWD 1870
Query: 677 ELTRVQGKK----TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
L + K+ T + L P V Y FRVIAVN+ G PS PS A P
Sbjct: 1871 ILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 268 bits (684), Expect = 3e-71
Identities = 182/627 (29%), Positives = 293/627 (46%), Gaps = 46/627 (7%)
Query: 368 CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTIL 427
C+A G P+PT KW NG P+ I+ NL + +YQC A N HG I
Sbjct: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNL--SDAGMYQCLAENKHGVIF 66
Query: 428 ANANIDVVDVRPLIQTKDGENYATV-VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRR 486
+NA + V+ V P + V VG + C+ ASP+ V +W+K ++ E R
Sbjct: 67 SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK-ENER 125
Query: 487 YHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLH 546
I E+G L+I T+ DAGSY+C N G + T NL +++ T++ V P + +
Sbjct: 126 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGE 185
Query: 547 MLELHCESKCDSHLKHSLKLSWS---------KDGEAFEINGTEDGRIIIDGANLTISNV 597
+ L C+ D L + +WS +DG+ FE G +D +L I N+
Sbjct: 186 SIVLPCQVTHDHSL--DIVFTWSFNGHLIDFDRDGDHFERVGGQDS-----AGDLMIRNI 238
Query: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSN 657
L+ G Y C T++D + + V P PPE + + E + + +L+W G D++S
Sbjct: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSP 298
Query: 658 ISEYIVEFEGNKEEPGRWEELTRV----QGKK-TTVILPLAPFVRYQFRVIAVNEVGRSQ 712
I+ Y+++ W+ ++ V GK T ++ L P+V Y+FR +A N +G +
Sbjct: 299 ITMYVIQ--ARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 356
Query: 713 PSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGA 772
PS+PS+ T A P+ P N+ E++I WE + QNG G Y V ++P G
Sbjct: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 416
Query: 773 PVEW-----EEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDT 827
+ W + + R + ++P++VKV N G GP + +YS E+ P
Sbjct: 417 MI-WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
Query: 828 APVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNI--LR 885
P +++T ++V W++ P ++ GR++GY++ +W R KE N +R
Sbjct: 476 PPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYW--------RHEDKEENARKIR 526
Query: 886 FSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDK 945
G + S + +L +HL V AYNS G GP S T + P QP +
Sbjct: 527 TVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD 586
Query: 946 DTATLSWGLPKKLN--GNLTGYLLQYQ 970
L+W K L+ + GY + Y+
Sbjct: 587 SKIILNWDQVKALDNESEVKGYKVLYR 613
Score = 73.9 bits (180), Expect = 9e-13
Identities = 69/304 (22%), Positives = 122/304 (40%), Gaps = 54/304 (17%)
Query: 56 ECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKL 115
EC+A G P+PT+ W K+G P T RI + I N G Y+C A NK
Sbjct: 8 ECKANGRPKPTYKWLKNGEPL-LTRDRIQIEQGTLNITIVNLSD----AGMYQCLAENKH 62
Query: 116 GIAMSEEIEFIVPSVPKFPKEKIDPLE-VEEGDPIVLPCNPPKGLPPLHIYWMNIELEHI 174
G+ S ++ P F + + + V+ G +V+ C P P++ + ++ +
Sbjct: 63 GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI--L 120
Query: 175 EQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSS 234
+++ER+ +S+ G+L NV + D+ Y C A H +S
Sbjct: 121 KENERITISEDGNLRIINVTKSDA-GSYTCIAT--------------------NHFGTAS 159
Query: 235 SSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLEC-----------FAEGL 283
S+ N + + ++++PP SS+ + GE ++L C F
Sbjct: 160 ST------GNLVVKDPTRVMVPP------SSMDVTVGESIVLPCQVTHDHSLDIVFTWSF 207
Query: 284 PTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIV 343
+D+++ G R ++ L I N+ + G Y C + + +IV
Sbjct: 208 NGHLIDFDRDGDHFE--RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV 265
Query: 344 EEPP 347
PP
Sbjct: 266 RGPP 269
Score = 68.9 bits (167), Expect = 3e-11
Identities = 136/638 (21%), Positives = 230/638 (36%), Gaps = 61/638 (9%)
Query: 272 EILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNF 331
E + EC A G P P W K G L + G TL I V+ D G Y+C A N
Sbjct: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAENK 61
Query: 332 LGT--ATHDFHVIVEEPP-RWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVD 388
G + + VI P T + + G ++ C+ + P+P W+ G +
Sbjct: 62 HGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDIL 120
Query: 389 NHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGEN 448
+ + N+ + Y C A+N GT + N+ V D P +
Sbjct: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD--PTRVMVPPSS 178
Query: 449 YATVVGYSAFLHCEFF--ASPEAVVSWQKVEEVKPLEGRRYHIY------ENGTLQINRT 500
VG S L C+ S + V +W + + H G L I
Sbjct: 179 MDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI 238
Query: 501 TEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKL--HMLELHCESKCDS 558
+ AG Y C V+ ++ + + A+L +R P+ I ++ +L D+
Sbjct: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEITDTTAQLSWRPGPDN 295
Query: 559 HLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAAD 618
H ++ + ++ + +IDG T + V L Y +
Sbjct: 296 HSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEY--------EFRTV 347
Query: 619 ITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEE--PGR-- 674
V + P P +E V +G + SE ++ +E EE GR
Sbjct: 348 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGG--GGSKSELVITWETVPEELQNGRGF 405
Query: 675 -WEELTRVQGKKTTVILPLA---------------PFVRYQFRVIAVNEVGRSQPSQPSD 718
+ R GK ++ LA PF ++ +V N G P P+
Sbjct: 406 GYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTT 464
Query: 719 HHETPPAAPDRNPQNIRVQASQPKEMIIKW-EPLKSMEQNGPGLEYRVTWKPQGAPVEWE 777
+ P + P +I ++ ++ + W PL+ G E + W+ +
Sbjct: 465 VVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY-WRHEDKEENAR 523
Query: 778 E-ETVTNHTLRVMTPAVYAP-YDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVD 835
+ TV N T +T + Y + V+A N G+GP +V + + + P P G
Sbjct: 524 KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPP---GNI 580
Query: 836 VINSTLVKV--TWSTVPKDRVHGRLKGYQINW-WKTKS 870
+ NS+ K+ W V +KGY++ + W +S
Sbjct: 581 IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQS 618
Score = 61.6 bits (148), Expect = 4e-09
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 9/178 (5%)
Query: 266 ITILK-GEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNY 324
+T++K G +++EC + P P W K L + + L+I NV+ D G+Y
Sbjct: 88 VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSY 147
Query: 325 RCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTI--KWRV 382
C A+N GTA+ +++V++P R P S + G + +L C+ + I W
Sbjct: 148 TCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSF 207
Query: 383 NGSPV------DNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDV 434
NG + D+ G ++ N+Q H Y C + A A++ V
Sbjct: 208 NGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV 265
Score = 45.4 bits (106), Expect = 3e-04
Identities = 48/159 (30%), Positives = 67/159 (42%), Gaps = 19/159 (11%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
IEC+ K +P+P ++W K G + RI S + G RI N G Y C A+N
Sbjct: 99 IECKPKASPKPVYTW-KKGRDILKENERITISED-GNLRIINV--TKSDAGSYTCIATNH 154
Query: 115 LGIAMSEEIEFIVPSVPKFPKEKIDP---LEVEEGDPIVLPC--NPPKGLPPLHIYWMNI 169
G A S V K P + P ++V G+ IVLPC L + + N
Sbjct: 155 FGTASSTG-----NLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 209
Query: 170 ELEHIEQD----ERV-YMSQKGDLYFANVEEKDSRNDYC 203
L ++D ERV GDL N++ K + C
Sbjct: 210 HLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 248
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 225 bits (574), Expect = 2e-58
Identities = 214/802 (26%), Positives = 336/802 (41%), Gaps = 72/802 (8%)
Query: 264 SSITILKGEILLLECFAEG-LPTPQVDWNKIGGDLPKGRETKENY--GKTLKIENVSYQ- 319
S ++G +LL+C AE P + W K G L G + ++ +L I+N+ +
Sbjct: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
Query: 320 ----DKGNYRCTASNFLGTA----THDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAE 371
D+G Y+C AS LG + + V V P R+ + +S G +L CE
Sbjct: 107 HHKPDEGLYQCEAS--LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
Query: 372 GEPQPTIKWRVNGSPVDNHPFAGD---VVFPR-EISFTNLQPNHTAVYQCEASNVHGTIL 427
GEP PTI W+ N D P GD VV P + + LQP +Y+C A N +
Sbjct: 165 GEPMPTIHWQKNQQ--DLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRT 222
Query: 428 AN-ANIDVVDV----RPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
N A + ++ R L + N + G A L C P +W + EEV L
Sbjct: 223 GNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQL 282
Query: 483 EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRI 542
++Y + L I+ T++D+G Y+C V + +A L + P N
Sbjct: 283 RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSN--- 339
Query: 543 PKLHMLE-LHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLED 601
L+ E + E +C K ++W K+G+ D I+ G+NL I V D
Sbjct: 340 --LYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI---PSDYFQIVGGSNLRILGVVKSD 394
Query: 602 QGIYCCSAHTALDSAADITQVTVLD--------VPDPPENLHLSERQNRSVRLTWEAGAD 653
+G Y C A +A Q+ V +P P ++ +R VRL+W A+
Sbjct: 395 EGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAE 454
Query: 654 HNSNISEYIVEFEGNKEEPGRWEELTRVQ-GKKTTVILPLAPFVRYQFRVIAVNEVGRSQ 712
NI + V F ++E R L Q G + L P Y FRV+A NE G +
Sbjct: 455 AKGNIQTFTVFF--SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512
Query: 713 PSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGA 772
SQP P +N++ ++ P ++I WEP NGP YR+
Sbjct: 513 SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVST 570
Query: 773 PVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIH 832
E E V + ++ + Y ++ A N+ G G +T+ + D P P
Sbjct: 571 GKEQNIE-VDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
Query: 833 GVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNS 892
++V+NS +KV+W P +G + GY+I KT G E N L +
Sbjct: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTR--RGEMETLEPNNLWY------ 681
Query: 893 GMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEG------VPEQPTFLKVIKVDKD 946
+ L+ S++ V A G GP S Y +TPE VP+QP+ L V + +
Sbjct: 682 -LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHV-RPQTN 739
Query: 947 TATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LSNLNATTKY 1005
+SW P N + GY++ Y + + E + SK ++ + L +++ Y
Sbjct: 740 CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAE-------TVRVDSKQRYYSIERLESSSHY 792
Query: 1006 KFYLRACTSQGCGKPITEESST 1027
L+A + G G P+ E ++T
Sbjct: 793 VISLKAFNNAGEGVPLYESATT 814
Score = 121 bits (304), Expect = 4e-27
Identities = 165/704 (23%), Positives = 278/704 (39%), Gaps = 68/704 (9%)
Query: 348 RWTKKPQSAVYSTGSNGILLCEAEGE-PQPTIKWRVNGSPV------DNHPFAGDVVFPR 400
R+ +P AV G N +L C AE + P IKW+ +G + + + +
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100
Query: 401 EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 460
I + +YQCEAS + + V PL E+ +G + L
Sbjct: 101 NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK 160
Query: 461 CEFFASPEAVVSWQK-VEEVKPLEG-RRYHIYENGTLQINRTTEEDAGSYSCWVEN-AIG 517
CE P + WQK +++ P+ G R + +G LQI+R D G Y C N A
Sbjct: 161 CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS 220
Query: 518 KTAVTANLDIRNATKLR------VSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD 571
+T A + I + L P N + L C C S +W +
Sbjct: 221 RTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEC---CVSGYPPP-SFTWLRG 276
Query: 572 GEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP--- 628
E ++ + ++ G+NL ISNVT +D G+Y C ++ + ++TVL P
Sbjct: 277 EEVIQLRSKKYS--LLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
Query: 629 DPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTV 688
+ P NL+ E + T N + G+ P + ++ G
Sbjct: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMK-----NGDVVIP---SDYFQIVGGSNLR 386
Query: 689 ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRN-----PQNIRVQASQPKE 743
IL + ++ +A NE G +Q S + PA P + P+++ +
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTS--AQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRF 444
Query: 744 MIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKV 801
+ + W P E G + V + +G E T +L++ + A Y +V
Sbjct: 445 VRLSWRP--PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
Query: 802 QAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINS-TLVKVTWSTVPKDRVHGRLKG 860
A N+ G G Q + + + + PV + V S T + +TW P +G ++G
Sbjct: 503 VAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWE--PPAYANGPVQG 560
Query: 861 YQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPES 920
Y++ + + G+ EV+ L + + L F+E+ L LAYN G G +
Sbjct: 561 YRLFCTEVST---GKEQNIEVDGLSYK-------LEGLKKFTEYSLRFLAYNRYGPGVST 610
Query: 921 EPYIFQTPEGVPE-QPTFLKVIKVDKDTATLSWGLPKK--LNGNLTGYLLQYQIINDTYE 977
+ T VP P + + V+ + +SW P NG +TGY ++++ E
Sbjct: 611 DDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE 670
Query: 978 IGELNDINITTPSKPSWHL-SNLNATTKYKFYLRACTSQGCGKP 1020
+ L N+ W+L + L ++Y F + A T G G P
Sbjct: 671 METLEPNNL-------WYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
Score = 109 bits (273), Expect = 1e-23
Identities = 227/1045 (21%), Positives = 402/1045 (38%), Gaps = 153/1045 (14%)
Query: 55 IECEAKGNPE-PTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHF---QGKYRCF 110
++C A+ + P W KDG ++G+ I N H H +G Y+C
Sbjct: 59 LDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCE 118
Query: 111 AS-NKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNP-PKGLPPLHIYWMN 168
AS G +S + V +F + + + GD ++L C + +P +H
Sbjct: 119 ASLGDSGSIISRTAKVAVAGPLRFLSQT-ESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQ 177
Query: 169 IELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLK 228
+L I D RV + G L + ++ D Y C A P
Sbjct: 178 QDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPA------------------ 218
Query: 229 HANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQV 288
++ + + E+ ++ R+ L P S++ ++G+ +LEC G P P
Sbjct: 219 -SSRTGNEAEVRILSDPGLHRQLYFLQRP------SNVVAIEGKDAVLECCVSGYPPPSF 271
Query: 289 DWNKIGGDLPKGRETKENY--GKTLKIENVSYQDKGNYRC--TASNFLGTATHDFHVIVE 344
W + G ++ + R K + G L I NV+ D G Y C T N +A+ + V+V
Sbjct: 272 TWLR-GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV- 329
Query: 345 EPPRWTKKPQSAVYSTGSNGILL-CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREIS 403
P W S +Y+ S I C G+P PT+ W NG V + +V +
Sbjct: 330 --PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYF-QIVGGSNLR 386
Query: 404 FTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD-----GENYATVVGYSAF 458
+ + YQC A N G +A + V +P I + + V+ S F
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVP--KPAIPSSSVLPSAPRDVVPVLVSSRF 444
Query: 459 LHCEFFASPEAVVSWQKVEEVKPLEG----RRYHIYENGTLQINRTTEEDAGSYSCWVEN 514
+ + EA + Q EG R + + G+LQ+ + Y+ V
Sbjct: 445 VRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
Query: 515 AIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA 574
++ I+ AT+ + P + L + S S+ ++W A
Sbjct: 505 YNEWGPGESSQPIKVATQPELQVPGP-VENLQAV---------STSPTSILITWEPPAYA 554
Query: 575 -----------FEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALD---SAADIT 620
E++ ++ I +DG + + + + A+ S DIT
Sbjct: 555 NGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDIT 614
Query: 621 QVTVLDVPD-PPENLHLSERQNRSVRLTW--EAGADHNSNISEYIVEFEGNKEEPGRWEE 677
VT+ DVP PP+N+ L +RS++++W N I+ Y + +++ R E
Sbjct: 615 VVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR---HRKTTRRGEM 671
Query: 678 LTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS-----QPSDHHETPPAAPDRNPQ 732
T + L +Y F+V A+ G PS + ++ PD+ P
Sbjct: 672 ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQ-PS 730
Query: 733 NIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPA 792
++ V+ Q +I+ W P + P + R G + E T+RV +
Sbjct: 731 SLHVRP-QTNCIIMSWTPPLN-----PNIVVRGYIIGYGVGSPYAE------TVRVDSKQ 778
Query: 793 VY---------APYDVKVQAINQLGSG------------PDPQSVTLYSG--EDYPDTAP 829
Y + Y + ++A N G G DP Y +D+P + P
Sbjct: 779 RYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
Query: 830 VIH-------GVDVINST--LVKVTWS--TVPKDRVHGRLKGYQINWWKTKSLLDGRTHP 878
+ GV + T V+V+W+ +VPK++ ++ Y + W +T +
Sbjct: 839 DLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRW-RTSFSASAKYKS 897
Query: 879 KEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTF 937
++ L ++ +G+ P+ + + +V+ ++ + S T E P P
Sbjct: 898 EDTTSLSYTA---TGLKPN----TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKD 950
Query: 938 LKVI-KVDKDTATL-SWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPS--KPS 993
L VI + K A + SW P + NG +T Y+L Y + + ++D + T S + +
Sbjct: 951 LTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNI----PIDDWIMETISGDRLT 1006
Query: 994 WHLSNLNATTKYKFYLRACTSQGCG 1018
+ +LN T Y F ++A S+G G
Sbjct: 1007 HQIMDLNLDTMYYFRIQARNSKGVG 1031
Score = 80.5 bits (197), Expect = 9e-15
Identities = 213/994 (21%), Positives = 350/994 (35%), Gaps = 199/994 (20%)
Query: 38 IKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNE 97
+ Q++ AF D ++CE G P PT W K+ D IP ++
Sbjct: 143 LSQTESVTAFMGDTVL-LKCEVIGEPMPTIHWQKNQQ-----DLTPIPGDSRVVVLPSGA 196
Query: 98 GHISHFQ----GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKE-----KIDPLEVEEGDP 148
IS Q G YRC A N E E + S P ++ + + EG
Sbjct: 197 LQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKD 256
Query: 149 IVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG-DLYFANVEEKDSRNDYCCFAA 207
VL C G PP W+ E E I+ + Y G +L +NV + DS Y C
Sbjct: 257 AVLECCV-SGYPPPSFTWLRGE-EVIQLRSKKYSLLGGSNLLISNVTDDDS-GMYTCVVT 313
Query: 208 FPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSIT 267
+ K+ N S+S+ + +L+PP S++
Sbjct: 314 Y-------------------KNENISASA-------------ELTVLVPPWFLNHPSNLY 341
Query: 268 ILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCT 327
+ + EC G P P V+W K G + + G L+I V D+G Y+C
Sbjct: 342 AYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401
Query: 328 ASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGIL---------------LCEAEG 372
A N G A +IV +P P S+V + ++ EA+G
Sbjct: 402 AENEAGNAQTSAQLIVPKP----AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKG 457
Query: 373 EPQP-TIKWRVNGSPVDNHPFAGDVVFPREISFT--NLQPNHTAVYQCEASNVHGTILAN 429
Q T+ + G DN A + P + T NL+P ++ A N G ++
Sbjct: 458 NIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESS 514
Query: 430 ANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAV-VSWQKVEEVK-PLEGRRY 487
I V L EN V SP ++ ++W+ P++G R
Sbjct: 515 QPIKVATQPELQVPGPVENLQAV-----------STSPTSILITWEPPAYANGPVQGYRL 563
Query: 488 HIYENGTLQINRTTEEDAGSYSC-------------WVENAIGKTAVTANLDIRNATKLR 534
E T + + E D SY N G T ++ + + +
Sbjct: 564 FCTEVSTGK-EQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP 622
Query: 535 VSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTI 594
+P P+ L ++ S+K+SW +GT++G I G +
Sbjct: 623 SAP--PQNVSLEVVN-----------SRSIKVSWLPPP-----SGTQNG--FITGYKIRH 662
Query: 595 SNV-------TLEDQGIYCCSAHTALDSAADIT-QVTVLDV--PDPPENLHLSER----- 639
TLE ++ T L+ + + QV+ + V PP N + +E
Sbjct: 663 RKTTRRGEMETLEPNNLW--YLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
Query: 640 ----------------QNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQG 683
Q + ++W + N + YI+ + + E RV
Sbjct: 721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSP----YAETVRVDS 776
Query: 684 KKTTV-ILPLAPFVRYQFRVIAVNEVGR-------------SQPSQPSDHH----ETPPA 725
K+ I L Y + A N G + P+ P D++ + P +
Sbjct: 777 KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTS 836
Query: 726 APDRN-----PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLE---YRVTWKPQ---GAPV 774
PD + P ++ A + + W S+ +N E Y V W+ A
Sbjct: 837 VPDLSTPMLPPVGVQAVALTHDAVRVSWAD-NSVPKNQKTSEVRLYTVRWRTSFSASAKY 895
Query: 775 EWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGV 834
+ E+ T ++T + P + V V + + T Y E P +AP V
Sbjct: 896 KSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY--EAAPTSAPKDLTV 953
Query: 835 DVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILR-FSGQRNSG 893
V S P +G++ Y + + K++ P + I+ SG R +
Sbjct: 954 ITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNI------PIDDWIMETISGDRLTH 1007
Query: 894 MVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQT 927
+ L+ + ++ + A NSKG GP S+P +F+T
Sbjct: 1008 QIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 214 bits (545), Expect = 4e-55
Identities = 230/1016 (22%), Positives = 407/1016 (40%), Gaps = 130/1016 (12%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQ-----GKYRC 109
+ C G + SW ++G + P N I +E I G Y+C
Sbjct: 333 LSCSVTGTEDQELSWYRNGEI-------LNPGKNVRITGINHENLIMDHMVKSDGGAYQC 385
Query: 110 FASNKLGIAMSEEIEFIV----PSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIY 165
F K ++ + ++ ++ P + EK+ V +P+ L CN KG P I
Sbjct: 386 FV-RKDKLSAQDYVQVVLEDGTPKIISAFSEKV----VSPAEPVSLMCNV-KGTPLPTIT 439
Query: 166 WMNIELEHI-----EQDERVYMSQKGDLYFANVEEKDSRND--YCCFAAFPRLRTIVQKM 218
W ++ + I + ++ S+ + + N+ R+ Y C A
Sbjct: 440 W-TLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTA------------ 486
Query: 219 PMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLEC 278
N+S+ ++ N R P + P +IT + G + C
Sbjct: 487 ------------NNSAGVVLYQARINV---RGPASIRPM------KNITAIAGRDTYIHC 525
Query: 279 FAEGLPTPQVDWNKIGGDLP-KGRETKENYGKTLKIENVSYQ-DKGNYRCTASNFLGTAT 336
G P + W K LP R+ TLK+ +V + D+G Y C +T
Sbjct: 526 RVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLST 585
Query: 337 -HDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA-EGEPQPTIKWRVNGSPVDNH--PF 392
HV V+ PP + + + +S G + C G+ TI W+ +G P+
Sbjct: 586 SQSVHVTVKVPP-FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVT 644
Query: 393 AGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRP--LIQTKDGENYA 450
++ F + +NL H Y C A N + + + +V V P ++Q +D +
Sbjct: 645 IDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDG-- 701
Query: 451 TVVGYSAFLHCEFFASPEAVVSWQ-----KVEEVKPLE-GRRYHIYENGTLQINRTTEED 504
+ G + L+C P + W+ V + +P+ R + NG+L I EED
Sbjct: 702 -IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
Query: 505 AGSYSCWVENAIGK-TAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHS 563
+G Y C V N +G + + L ++ + P + E+ C +H +
Sbjct: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEM----SCTAHGEKP 816
Query: 564 LKLSWSKDGEAFE-------INGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSA 616
+ + W K+ ++ E G +I + L I ED G + C A +
Sbjct: 817 IIVRWEKEDRIINPEMARYLVSTKEVGEEVI--STLQILPTVREDSGFFSCHAINSYGED 874
Query: 617 ADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE 676
I Q+TV + PDPPE + + + + R++ L W G D NS I+ Y +E + + W+
Sbjct: 875 RGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDS---WD 930
Query: 677 ELTRVQGKK----TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQ 732
R + + I+ + P Y R+ A N +G+S+PS AAPD PQ
Sbjct: 931 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTI-TADEAAPDGPPQ 989
Query: 733 NIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHT------L 786
+ ++ + + + W+ K QNG Y++ ++ ++ ++ T
Sbjct: 990 EVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVY 1049
Query: 787 RVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTW 846
+ + Y + VQA N+ G+GP Q + + ED P P + + ++W
Sbjct: 1050 TLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISW 1109
Query: 847 STVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHL 906
ST+ K+ ++G L+G+++ +W +L+DG I + + S + L+ ++ + +
Sbjct: 1110 STLSKEALNGILQGFRVIYWA--NLMDGELG----EIKNITTTQPSLELDGLEKYTNYSI 1163
Query: 907 TVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYL 966
VLA+ G G SE +T E VP P +K +SW P KLNG + Y
Sbjct: 1164 QVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYT 1223
Query: 967 L----QYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCG 1018
+ Y + +E +P S+ + NL+ +Y ++ A TS G G
Sbjct: 1224 VFCSHPYPTVISEFE---------ASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
Score = 150 bits (378), Expect = 9e-36
Identities = 206/933 (22%), Positives = 347/933 (37%), Gaps = 111/933 (11%)
Query: 35 PTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRI 94
P II +V P E + C KG P PT +WT D +P I + +
Sbjct: 407 PKIISAFSEKVVSPA-EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNV 465
Query: 95 PNEGHISHFQ----GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIV 150
+ +IS Q G YRC A+N G+ + + + P + I + G
Sbjct: 466 VSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA---GRDTY 522
Query: 151 LPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAF-P 209
+ C G P I W +V G L ++V+++ +Y C P
Sbjct: 523 IHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQP 581
Query: 210 RLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITIL 269
+L T S S + K Q P E S
Sbjct: 582 QLST--------------------SQSVHVTVKVPPFIQ--------PFEFPRFSI---- 609
Query: 270 KGEILLLECFAEGLPTP-QVDWNKIGGDLPKGRE-TKEN--YGKTLKIENVSYQDKGNYR 325
G+ + + C P + W K G +P T +N + +L+I N+S GNY
Sbjct: 610 -GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYT 668
Query: 326 CTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVN-G 384
C A N H +IV PP++ +P+ G IL C AEG P PTI W+ + G
Sbjct: 669 CIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKG 728
Query: 385 SPVDN-HPFAGD----VVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRP 439
+ V P A + V+ + ++ + Y C+ SN G ++ + V +
Sbjct: 729 AGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788
Query: 440 LIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYEN------- 492
+I + AT G + C +V W+K + + E RY +
Sbjct: 789 MITSYPNTTLAT-QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVI 847
Query: 493 GTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR---NATKLRVSPKNPRIPKLHM-- 547
TLQI T ED+G +SC N+ G+ L ++ + ++ + R L
Sbjct: 848 STLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTM 907
Query: 548 ----------LELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNV 597
++ C++K D SW +++ + IID I
Sbjct: 908 GFDGNSPITGYDIECKNKSD---------SWDSAQRTKDVSPQLNSATIID-----IHPS 953
Query: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDVPD-PPENLHLSERQNRSVRLTWEAGADH-- 654
+ +Y + + + ++T PD PP+ +HL ++S+R+TW+A H
Sbjct: 954 STYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQ 1013
Query: 655 NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNEVGRS 711
N I Y + + + V + + L F +Y V A N G +
Sbjct: 1014 NGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAG-T 1072
Query: 712 QPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTW---K 768
PS T P P+N++ A+ P+ + I W L NG +RV +
Sbjct: 1073 GPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANL 1132
Query: 769 PQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTA 828
G E + T T +L + Y Y ++V A + G G + + + ED P
Sbjct: 1133 MDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPP 1192
Query: 829 PVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSG 888
+ ++++V V+W +P +++G ++ Y ++ +P ++ S
Sbjct: 1193 AGVKAA-AASASMVFVSW--LPPLKLNGIIRKY--------TVFCSHPYPTVISEFEASP 1241
Query: 889 QRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESE 921
S +P+L ++ + V+A S G G SE
Sbjct: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE 1274
Score = 115 bits (289), Expect = 2e-25
Identities = 187/856 (21%), Positives = 328/856 (38%), Gaps = 90/856 (10%)
Query: 216 QKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESG-SESSITILKGEIL 274
QK L + +++ ++ S E+ ++ + K + P ++ S + G +
Sbjct: 272 QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQV 331
Query: 275 LLECFAEGLPTPQVDWNKIGGDLPKGRETKEN--YGKTLKIENVSYQDKGNYRCTASNFL 332
L C G ++ W + G L G+ + + L ++++ D G Y+C
Sbjct: 332 SLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDK 391
Query: 333 GTATHDFHVIVEE-PPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPV---D 388
+A V++E+ P+ V S L+C +G P PTI W ++ P+
Sbjct: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGG 451
Query: 389 NHPFA------GDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDV---VDVRP 439
+H + G+VV IS + ++ VY+C A+N G +L A I+V +RP
Sbjct: 452 SHRISQMITSEGNVVSYLNISSSQVRDG--GVYRCTANNSAGVVLYQARINVRGPASIRP 509
Query: 440 LIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINR 499
+ +N + G ++HC P + W K + P R+ NGTL+++
Sbjct: 510 M------KNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSD 563
Query: 500 TTEE-DAGSYSCWVENAIGKTAVTANLDIRNATKLR--VSP-KNPRIPKLHMLELHCESK 555
+E D G Y+C N + + ++ + + K+ + P + PR + + C
Sbjct: 564 VQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVV 620
Query: 556 CDSHLKHSLKLSWSKDGEAF--EINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTAL 613
+ ++W KDG + T D I ++L ISN++L G Y C A
Sbjct: 621 SGDL---PITITWQKDGRPIPGSLGVTIDN--IDFTSSLRISNLSLMHNGNYTCIAR--- 672
Query: 614 DSAADITQVTVLDVPDPPENLHLSERQN----RSVRLTWEAGADHNSNISEYIVEFEGNK 669
+ AA + + L V PP+ + Q+ ++V L A I + G
Sbjct: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732
Query: 670 E-EPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPD 728
+ +P +V + +I + + N+VG + S+ PA
Sbjct: 733 QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMIT 791
Query: 729 RNPQNIRVQASQPKEM----------IIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEE 778
P Q KEM I++WE + N Y V+ K G E
Sbjct: 792 SYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK-EDRIINPEMARYLVSTKEVG------E 844
Query: 779 ETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVIN 838
E ++ TL+++ AIN G +T+ D P+ + +
Sbjct: 845 EVIS--TLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE-----IKDVK 897
Query: 839 STLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSL 898
+ + + W T+ D + + GY I D K+V S Q NS + +
Sbjct: 898 ARTITLRW-TMGFDG-NSPITGYDIECKNKSDSWDSAQRTKDV-----SPQLNSATIIDI 950
Query: 899 DAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPE-QPTFLKVIKVDKDTATLSWGLPKK 957
S + + + A N G S E P+ P + + + + ++W PKK
Sbjct: 951 HPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKK 1010
Query: 958 --LNGNLTGYLLQYQIINDTYEIGELNDINI----TTPSKPSWHLSNLNATTKYKFYLRA 1011
NG + GY + Y+ Y G NI T+ + L NLN T+Y ++A
Sbjct: 1011 HLQNGIIRGYQIGYR----EYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
Query: 1012 CTSQGCGKPITEESST 1027
C G G P ++E T
Sbjct: 1067 CNRAGTG-PSSQEIIT 1081
Score = 112 bits (281), Expect = 2e-24
Identities = 233/1057 (22%), Positives = 403/1057 (38%), Gaps = 187/1057 (17%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
I C G P + W K+ N F +HR + N+GT ++ ++ +G+Y C +
Sbjct: 523 IHCRVIGYPYYSIKWYKNSNLLPF-NHRQVAFENNGTLKL-SDVQKEVDEGEYTCNVLVQ 580
Query: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEE---GDPIVLPCNPPKGLPPLHIYWMNIEL 171
++ S+ + V VP F I P E G + +PC G P+ I W
Sbjct: 581 PQLSTSQSVHVTV-KVPPF----IQPFEFPRFSIGQRVFIPCVVVSGDLPITITW----- 630
Query: 172 EHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHAN 231
++D R G + N++ S + + + N A
Sbjct: 631 ---QKDGRPIPGSLG-VTIDNIDFTSSLR--------------ISNLSLMHNGNYTCIAR 672
Query: 232 DSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWN 291
+ +++ E S+ I + PK ++ P + + G+ ++L C AEG P P + W
Sbjct: 673 NEAAAVEHQSQL--IVRVPPKFVVQPRDQDG------IYGKAVILNCSAEGYPVPTIVWK 724
Query: 292 -KIGGDLPKGRETKEN------YGKTLKIENVSYQDKGNYRCTASNFLGT-ATHDFHVIV 343
G +P+ + N +L I++V +D G Y C SN +G + ++ V
Sbjct: 725 FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
Query: 344 EEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPRE-- 401
+ P T P + + + G + C A GE ++W + N A +V +E
Sbjct: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRII-NPEMARYLVSTKEVG 843
Query: 402 ---ISFTNLQPN---HTAVYQCEASNVHG--------TILANAN---IDVVDVRP----L 440
IS + P + + C A N +G T+ + I++ DV+ L
Sbjct: 844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITL 903
Query: 441 IQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRT 500
T + + + GY + C+ ++ S Q+ ++V P Q+N
Sbjct: 904 RWTMGFDGNSPITGYD--IECK--NKSDSWDSAQRTKDVSP--------------QLNSA 945
Query: 501 TEED---AGSYSC--WVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESK 555
T D + +YS + +N IGK+ + L I T +P P P+ E+H E
Sbjct: 946 TIIDIHPSSTYSIRMYAKNRIGKSEPSNELTI---TADEAAPDGP--PQ----EVHLEPI 996
Query: 556 CDSHLKHSLKLSWSKDGEAFE---INGTEDG-RIIIDGANLTISNVTLEDQG-------- 603
S++++W + + I G + G R G N + ++++ G
Sbjct: 997 SSQ----SIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLD 1052
Query: 604 -----------IYCCSAHTALDSAADITQVTVLDVPD-PPENLHLSERQNRSVRLTWEAG 651
+ C+ S+ +I T+ DVP PPEN+ S+ ++W
Sbjct: 1053 NLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112
Query: 652 ADH--NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILP-LAPFVRYQFRVIAVNEV 708
+ N + + V + N + G E+ + + ++ L L + Y +V+A
Sbjct: 1113 SKEALNGILQGFRVIYWANLMD-GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRA 1171
Query: 709 G---RSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
G RS+ + P P ++ A+ + + W P ++ NG +Y V
Sbjct: 1172 GDGVRSEQIFTRTKEDVPGP-----PAGVKAAAASASMVFVSWLP--PLKLNGIIRKYTV 1224
Query: 766 TWK-PQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDY 824
P + E + + + R+ + Y V V A+ G G + +T+
Sbjct: 1225 FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKA 1284
Query: 825 PDTAPVIHGVDVINSTLVKVTWS---TVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEV 881
P G V W +P V + W K D P V
Sbjct: 1285 PARILTFSGT-------VTTPWMKDIVLPCKAVGDPSPA--VKWMK-----DSNGTPSLV 1330
Query: 882 NILRFSGQRN-----SGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPT 936
I G+R+ S ++ ++ A + + +A N+ G S+ I VP
Sbjct: 1331 TI---DGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILNLQVQVPPDQP 1383
Query: 937 FLKVIKVDKDTATLSWGLPKKLNGN-LTGYLLQYQIINDTYEIGELNDINITTPSKPSWH 995
L V K + TLSW LP G+ + GY+LQY N + I+ PS+ S+
Sbjct: 1384 RLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSE----QWGSFPIS-PSERSYR 1437
Query: 996 LSNLNATTKYKFYLRACTSQGCGKPITE--ESSTLGE 1030
L NL T YKF L A G G+ I+E E+ TLG+
Sbjct: 1438 LENLKCGTWYKFTLTAQNGVGPGR-ISEIIEAKTLGK 1473
Score = 83.2 bits (204), Expect = 1e-15
Identities = 134/597 (22%), Positives = 215/597 (36%), Gaps = 73/597 (12%)
Query: 38 IKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRI--- 94
+ S +V F + C A G P T W + I + +GT +I
Sbjct: 27 VNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPF 86
Query: 95 -PNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKE-KIDPLEVEEGDPIVLP 152
P+ Y C A N G S+++ + +V + P +++ + G+ V
Sbjct: 87 PPSSFSTLIHDNTYYCTAENPSGKIRSQDVH--IKAVLREPYTVRVEDQKTMRGNVAVFK 144
Query: 153 CNPPKGLPPLHIYWMNIELEHIE--QDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPR 210
C P + +I ++ E + + R ++ G LY +V+ +D +Y C
Sbjct: 145 CIIPSSVEA-YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRY 203
Query: 211 LRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILK 270
Q +L V S + S + RK +
Sbjct: 204 TGETRQSNSARLFV--------SDPANSAPSILDGFDHRKA-----------------MA 238
Query: 271 GEILLLECFAEGLPTPQVDWNKIGGDLP-KGRETKENYGKTLKIENVSYQDKGNYRCTAS 329
G+ + L C A G P P W K L GR K G L IEN+ D G+Y C S
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIENIRPSDSGSYVCEVS 296
Query: 330 NFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDN 389
N GTA + V++P + T P+ S GS L C G + W NG ++
Sbjct: 297 NRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN- 355
Query: 390 HPFAGDVVFPREISFTNLQPNHT-----AVYQCEASNVHGTILANANIDVVDVRPLIQTK 444
G V I+ NL +H YQC + + + D P I +
Sbjct: 356 ---PGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA 412
Query: 445 DGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGT--------LQ 496
E + L C +P ++W +++ L+G + I + T L
Sbjct: 413 FSEKVVS-PAEPVSLMCNVKGTPLPTITW-TLDDDPILKGGSHRISQMITSEGNVVSYLN 470
Query: 497 INRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLR----VSPKNPRIPKLHMLELHC 552
I+ + D G Y C N+ G A +++R +R ++ R +H +
Sbjct: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGY 530
Query: 553 ESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLE-DQGIYCCS 608
K+S L ++ AFE NGT L +S+V E D+G Y C+
Sbjct: 531 PYYSIKWYKNSNLLPFNHRQVAFENNGT-----------LKLSDVQKEVDEGEYTCN 576
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/292 (25%), Positives = 111/292 (38%), Gaps = 34/292 (11%)
Query: 354 QSAVYSTGSNGILLCEAEGEPQPTIKWRV-NGSPVDN-------HPFAGDVVFP-REISF 404
Q V+++ + ++ C A G P T++W + G + + HP +FP SF
Sbjct: 32 QEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSF 91
Query: 405 TNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFF 464
+ L H Y C A N G I + ++ + V T E+ T+ G A C
Sbjct: 92 STL--IHDNTYYCTAENPSGKI-RSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIP 148
Query: 465 ASPEA---VVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDA-GSYSCWVENAIGKTA 520
+S EA VVSW+K + V + G R+ I G L I ED +Y C I +
Sbjct: 149 SSVEAYITVVSWEK-DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRC-----ITRHR 202
Query: 521 VTANLDIRNATKLRVSPKNPRIPKL--------HMLELHCESKCDSHLKHSLKLSWSKDG 572
T N+ +L VS P + M E C + W KD
Sbjct: 203 YTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDN 262
Query: 573 EAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 624
E++G + L I N+ D G Y C +A I ++ V
Sbjct: 263 MPLELSGRFQKTV----TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
Score = 53.1 bits (126), Expect = 2e-06
Identities = 204/1021 (19%), Positives = 356/1021 (34%), Gaps = 156/1021 (15%)
Query: 66 TFSWTKDGNPFYFTDHRIIPSNN-SGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIE 124
T +W KDG P + I + + + + RI N + + G Y C A N+ A+ + +
Sbjct: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHN--GNYTCIARNEAA-AVEHQSQ 683
Query: 125 FIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNI------ELEHIEQDE 178
IV PKF + D + G ++L C+ +G P I W + + I +
Sbjct: 684 LIVRVPPKFVVQPRDQDGIY-GKAVILNCSA-EGYPVPTIVWKFSKGAGVPQFQPIALNG 741
Query: 179 RVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTE 238
R+ + G L +V E+DS C K +ND +
Sbjct: 742 RIQVLSNGSLLIKHVVEEDSGYYLC------------------------KVSNDVGADV- 776
Query: 239 IGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNK------ 292
SK+ + + P ++ + ++ +G+ + C A G V W K
Sbjct: 777 --SKSMYLTVKIPAMI-----TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIIN 829
Query: 293 --IGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWT 350
+ L +E E TL+I +D G + C A N G + V+EPP
Sbjct: 830 PEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP--- 886
Query: 351 KKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFT----- 405
P+ + + I T++W + N P G + + S +
Sbjct: 887 DPPEIEIKDVKARTI-----------TLRWTMGFD--GNSPITGYDIECKNKSDSWDSAQ 933
Query: 406 -----NLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 460
+ Q N + S+ + +I A + P + + A G +H
Sbjct: 934 RTKDVSPQLNSATIIDIHPSSTY-SIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVH 992
Query: 461 CEFFASPEAVVSWQKVEEVKPLEG---RRYHI-----YENGTLQINRTTEEDAGSYSCWV 512
E +S V+W+ + K L+ R Y I G Q N + + +G +
Sbjct: 993 LEPISSQSIRVTWKAPK--KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYT 1050
Query: 513 ENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHC----ESKCDSHLKHSLKLSW 568
+ + K L ++ + P + I + ++ + + S+ +SW
Sbjct: 1051 LDNLNKFT-QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISW 1109
Query: 569 SKDGEAFEINGTEDGRIIIDGANLT------ISNVT-----LEDQGIYCCSAHT----AL 613
S + +NG G +I ANL I N+T LE G+ + ++ A
Sbjct: 1110 STLSKE-ALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
Query: 614 DSAAD------ITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEG 667
A D I T DVP PP + + V ++W N I +Y V
Sbjct: 1169 TRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFC-- 1226
Query: 668 NKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
+ P E + I L+ +Y V+AV GR S+ A
Sbjct: 1227 SHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPA 1286
Query: 728 DRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV--TWKPQGAPVEWEEETVTNHT 785
+ V K++++ P K++ P +++ P ++ +N +
Sbjct: 1287 RILTFSGTVTTPWMKDIVL---PCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
Query: 786 LRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVT 845
+ T A N GS ++ + D P + V +T +T
Sbjct: 1344 FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-------LTVSKTTSSSIT 1396
Query: 846 WSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFH 905
S +P D ++GY + + + S ++ S S + +L + +
Sbjct: 1397 LSWLPGDNGGSSIRGYILQYSEDNS--------EQWGSFPISPSERSYRLENLKCGTWYK 1448
Query: 906 LTVLAYNSKGAGPESEPYIFQT----PEGVPEQPTFLKVIKVDKDTATLSW---GLPKKL 958
T+ A N G G SE +T P+ EQ F + + W G P
Sbjct: 1449 FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCP--- 1505
Query: 959 NGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCG 1018
+T + L+Y+ T T+ SK S+ L +L T Y+ +R C S GC
Sbjct: 1506 ---ITSFTLEYRPFGTTV----WTTAQRTSLSK-SYILYDLQEATWYELQMRVCNSAGCA 1557
Query: 1019 K 1019
+
Sbjct: 1558 E 1558
Score = 34.3 bits (77), Expect = 0.75
Identities = 28/83 (33%), Positives = 36/83 (43%), Gaps = 11/83 (13%)
Query: 45 VAFPFDEYFQIECEAKGNPEPTFSWTKD--GNPFYFT--DHRIIPSNNSGTFRIPNEGHI 100
V P+ + + C+A G+P P W KD G P T R I SN S R
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVK---- 1350
Query: 101 SHFQGKYRCFASNKLGIAMSEEI 123
+ G Y C A+N G S+EI
Sbjct: 1351 AEDSGYYSCIANNNWG---SDEI 1370
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 211 bits (536), Expect = 4e-54
Identities = 244/1034 (23%), Positives = 396/1034 (38%), Gaps = 125/1034 (12%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
+ C G+PE T W ++ D I S + SH G Y+CFA+ K
Sbjct: 394 LSCALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSH-SGAYQCFATRK 451
Query: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHI 174
A I + P+ + + V G+ L C KG PP + W ++ E I
Sbjct: 452 AQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMC-AAKGAPPPTVTWA-LDDEPI 508
Query: 175 EQD-----ERVYMSQKGDLYFANVEEKDSRND--YCCFAAFPRLRTIVQKMPMKLTVNSL 227
+D + MS + NV R+ Y C A R +V + +N
Sbjct: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTA-----RNLVGSAEYQARIN-- 561
Query: 228 KHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQ 287
+ P + +IT + G L+ C G P
Sbjct: 562 --------------------------VRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYS 595
Query: 288 VDWNKIGGDLPKGRETKENYGKTLKIENVSY-QDKGNYRCTAS-NFLGTATHDFHVIVEE 345
+ W K LP TLK+ +V D+G Y C+ + + HV V+
Sbjct: 596 IKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKV 655
Query: 346 PPRWTKKPQSAVYSTGSNGILL----CEAEGEPQPTIKWRVNGSPVDNHPFAGDVV---- 397
PP Q + S G LL + G+ I WR +G + +G V
Sbjct: 656 PPLI----QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI----ISGSGVTIES 707
Query: 398 --FPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGY 455
F + +++ H Y C ASN T+ + +V V P + N + G
Sbjct: 708 KEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL-IVRVPPRFVVQPN-NQDGIYGK 765
Query: 456 SAFLHCEFFASPEAVVSWQKVE--------EVKPLEGRRYHIYENGTLQINRTTEEDAGS 507
+ L+C P V W+ + PL GR I N +L I EED G
Sbjct: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR-IQILPNSSLLIRHVLEEDIGY 824
Query: 508 YSCWVENAIGKT-AVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKL 566
Y C N +G + + L ++ + P K H EL+C ++ + + +
Sbjct: 825 YLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGE----RPIII 880
Query: 567 SWSKDGEAFEINGTEDGRIII-DGANLTISNVTLE-----DQGIYCCSAHTALDSAADIT 620
W K + + I D + +S + L+ D + C A + +
Sbjct: 881 RWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLI 940
Query: 621 QVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTR 680
Q+TV + PDPPE L + E + RS+ L W D NS I+ + +E++ + W+
Sbjct: 941 QLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDS---WDFKQS 996
Query: 681 VQGKKTTV----ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRV 736
+ T+ I+ L P Y R+ + N++GRS+PS+ T AAPD P ++ +
Sbjct: 997 TRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTI-STEEAAPDGPPMDVTL 1055
Query: 737 QASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWE------EETVTNHTLRVMT 790
Q + + + W+ K QNG Y++ ++ + + T + +
Sbjct: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
Query: 791 PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVP 850
+A Y V VQA N+ G+GP + + ED P P I S + ++WS P
Sbjct: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPP 1175
Query: 851 KDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910
+ ++G LKGY++ +W +DG + + R + ++ F+ + + VLA
Sbjct: 1176 RSTLNGVLKGYRVIFWSL--YVDGEWGEMQ----NITTTRERVELRGMEKFTNYSVQVLA 1229
Query: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLL--- 967
Y G G S QT E VP P +K + + +SW P K NG + Y +
Sbjct: 1230 YTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCS 1289
Query: 968 ---QYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEE 1024
Q YE T+P + + +++LN +Y ++ A TS G G + E
Sbjct: 1290 SPGSGQPAPSEYE---------TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN--SSE 1338
Query: 1025 SSTLGEGSKGIGKI 1038
T+ K KI
Sbjct: 1339 KVTIEPAGKAPAKI 1352
Score = 155 bits (392), Expect = 2e-37
Identities = 228/993 (22%), Positives = 375/993 (37%), Gaps = 148/993 (14%)
Query: 35 PTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRI 94
P I+ +V P E F + C AKG P PT +W D P S+ + + +
Sbjct: 468 PRIVSSFSEKVVNP-GEQFSLMCAAKGAPPPTVTWALDDEPIVRDG-----SHRTNQYTM 521
Query: 95 PNEGHISHFQ---------GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEE 145
+ ISH G YRC A N +G A + V P + +
Sbjct: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA-EYQARINVRGPPSI--RAMRNITAVA 578
Query: 146 GDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCF 205
G ++ C G P I W L + + R + + G L +V++ +Y C
Sbjct: 579 GRDTLINCRVI-GYPYYSIKWYKDALL-LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCS 636
Query: 206 AAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESS 265
+I Q + + + V L + PP G
Sbjct: 637 VLIQPQLSISQSVHVAVKVPPLIQPFE----------------------FPPASIG---- 670
Query: 266 ITILKGEILLLECFAEGLPTP-QVDWNKIGGDLPKGR----ETKENYGKTLKIENVSYQD 320
++L + C P ++ W K G + G E+KE + +L+I +VS +
Sbjct: 671 ------QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKE-FMSSLQISSVSLKH 723
Query: 321 KGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKW 380
GNY C ASN T + + +IV PPR+ +P + G G+L C +G P P + W
Sbjct: 724 NGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW 783
Query: 381 ---RVNGSPVDNH--PFAGDV-VFPR-EISFTNLQPNHTAVYQCEASNVHGTILANANID 433
+ +G+P H P G + + P + ++ Y C+ASN GT ++ +
Sbjct: 784 KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFL 843
Query: 434 VVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEV-KPLEGRRYHI--Y 490
V + P + T + G++ L+C ++ W+K + V P RY I
Sbjct: 844 TVKI-PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATK 902
Query: 491 ENG-----TLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKL 545
+NG TL++ D+ +SC N+ G+ L ++ P +P P+L
Sbjct: 903 DNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQ-------EPPDP--PEL 953
Query: 546 HMLELHCESKCDSHLKHSLKLSWSK--DGEA----FEI------------NGTEDGRIII 587
+ E+ S+ L W++ DG + F+I T + I
Sbjct: 954 EIREVKA---------RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI 1004
Query: 588 DGANLTISNVTLEDQGIYCCSAHT-----ALDSAADITQVTVLDVPD-PPENLHLSERQN 641
+ AN+ V L +Y ++ + + ++T T PD PP ++ L +
Sbjct: 1005 NQANI----VDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTS 1060
Query: 642 RSVRLTWEAGAD--HNSNISEYIVEFEGNKEEPGRWEELTRVQGKKT-----TVILPLAP 694
+S+++TW+A N I Y + + N PG + + V+ K T + L
Sbjct: 1061 QSIQVTWKAPKKELQNGVIRGYQIGYREN--SPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
Query: 695 FVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSM 754
F +Y V A N G + PS + T P + P+N+R + +I W
Sbjct: 1119 FAQYGVVVQAFNRAG-TGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRS 1177
Query: 755 EQNGPGLEYRVTWKPQGAPVEWEEE---TVTNHTLRVMTPAVYAPYDVKVQAINQLGSGP 811
NG YRV + EW E T T + + + Y V+V A Q G G
Sbjct: 1178 TLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGV 1237
Query: 812 DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSL 871
+ + + ED P G+ + S+ V S +P + +G ++ Y I S
Sbjct: 1238 RSSVLYIQTKEDVPGPPA---GIKAVPSSASSVVVSWLPPTKPNGVIRKYTI---FCSSP 1291
Query: 872 LDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGV 931
G+ P E S ++ + L+ ++ L V A S G G SE +
Sbjct: 1292 GSGQPAPSEYET---SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
Query: 932 PEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTG 964
P K+I T T W +L N G
Sbjct: 1349 P-----AKIISFG-GTVTTPWMKDVRLPCNSVG 1375
Score = 114 bits (286), Expect = 4e-25
Identities = 150/637 (23%), Positives = 240/637 (37%), Gaps = 66/637 (10%)
Query: 16 FLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSW-TKDGN 74
FLLL S P V + S QV F + C A G+P W G+
Sbjct: 66 FLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGD 125
Query: 75 PFYFTDHRIIPSNNSGTFRI----PNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
Y H I + +GT ++ P+ + Y C A N G S I V +V
Sbjct: 126 DIYDVPH-IRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIR--VKAV 182
Query: 131 PKFPKE-KIDPLEVEEGDPIVLPCNPPKGLPP-LHIYWMNIELEHIEQDERVYMSQKGDL 188
+ P +++ G+ V C P + + + + I + R +++ G L
Sbjct: 183 FREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGL 242
Query: 189 YFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQ 248
Y ++V+++D+ + Y C KH + G++ +
Sbjct: 243 YISDVQKEDALSTYRCIT---------------------KHKYSGETRQSNGAR---LSV 278
Query: 249 RKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK-GRETKENY 307
P +P G S + G + L C A G P P + W K G LP R TK
Sbjct: 279 TDPAESIPTILDGFHSQ-EVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
Query: 308 GKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILL 367
G T I ++ +D G Y C +N G+A ++V +P T P+ GS IL
Sbjct: 338 GLT--ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
Query: 368 CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREIS-----FTNLQPNHTAVYQCEASNV 422
C G P+ TI+W N V + + R +S T+ Q +H+ YQC A+
Sbjct: 396 CALTGSPEFTIRWYRNTELV----LPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
Query: 423 HGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
T A I + D P I + E G L C +P V+W +E
Sbjct: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVN-PGEQFSLMCAAKGAPPPTVTWALDDEPIVR 510
Query: 483 EG----RRYHIYENGTLQINRTTE---EDAGSYSCWVENAIGKTAVTANLDIRNATKLRV 535
+G +Y + + T+ T D G Y C N +G A +++R +R
Sbjct: 511 DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRA 570
Query: 536 SPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTIS 595
+ L ++C + + +S+K W KD N + ++ + L ++
Sbjct: 571 MRNITAVAGRDTL-INC--RVIGYPYYSIK--WYKDALLLPDNHRQ---VVFENGTLKLT 622
Query: 596 NVTL-EDQGIYCCSAHTALDSAADITQVTVLDVPDPP 631
+V D+G Y CS + I+Q + V PP
Sbjct: 623 DVQKGMDEGEYLCS--VLIQPQLSISQSVHVAVKVPP 657
Score = 58.5 bits (140), Expect = 4e-08
Identities = 69/282 (24%), Positives = 120/282 (42%), Gaps = 27/282 (9%)
Query: 556 CDSHLKHSLKLSWSKDGEAFEINGTEDG-RIIIDGANLTISNVTLEDQGIYCCSAHTALD 614
C+S + + W+KD E I + DG R+I L + V ED G Y C+A
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 615 SAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGR 674
I + V PD P L +S+ S+ LTW G + S+I +++++ + E
Sbjct: 1431 FDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSE--E 1487
Query: 675 WEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS---QPSDHHETPPAAPDRNP 731
W+++ +++ + L Y+ ++ A N VG + S + H P + D++
Sbjct: 1488 WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQH- 1546
Query: 732 QNIRVQASQPKEMIIKWE----PLKSMEQNGPGLEYRV--TWKPQGAPVEWEEETVTNHT 785
+ ++ + + W P+ ++ LEYR TW QG E
Sbjct: 1547 LFTHINSTHARLNLQGWNNGGCPITAIV-----LEYRPKGTWAWQGLRANSSGEVF---- 1597
Query: 786 LRVMTPAVYAPYDVKVQAINQLGSGPD-PQSVTL-YSGEDYP 825
L + A + Y+++++A N G G + Q TL Y G P
Sbjct: 1598 LTELREATW--YELRMRACNSAGCGNETAQFATLDYDGSTIP 1637
Score = 57.0 bits (136), Expect = 1e-07
Identities = 95/412 (23%), Positives = 160/412 (38%), Gaps = 30/412 (7%)
Query: 615 SAADITQVTVLDVPD-PPENLHLSERQNRSVRLTWEAGADHNSN--ISEYIVEFEGNKEE 671
S+++I T+ DVP PPEN+ + ++W N + Y V F +
Sbjct: 1137 SSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVD 1196
Query: 672 PGRWEELTRVQGKKTTVILP-LAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRN 730
G W E+ + + V L + F Y +V+A + G S + +T P
Sbjct: 1197 -GEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVL-YIQTKEDVPGP- 1253
Query: 731 PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGA--PVEWEEETVTNHTL-R 787
P I+ S +++ W P + NG +Y + G+ P E ET R
Sbjct: 1254 PAGIKAVPSSASSVVVSWLP--PTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1311
Query: 788 VMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWS 847
+ Y + V A+ G G + VT+ P A +I + + +K
Sbjct: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAP--AKIISFGGTVTTPWMKDV-- 1367
Query: 848 TVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLT 907
+P + V + W K + P ++ R + ++ ++ A + T
Sbjct: 1368 RLPCNSVGDPAPA--VKWTKDS---EDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
Query: 908 VLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLL 967
A N+ G + Q P P+QP L V K + TL+W ++ G++L
Sbjct: 1423 CTATNTGGFDTIIVNLLVQVP---PDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVL 1478
Query: 968 QYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGK 1019
QY + N E D+ I++ S+ S+ L +L T YK L A S G G+
Sbjct: 1479 QYSVDNSE----EWKDVFISS-SERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 7/102 (6%)
Query: 276 LECFAEGLPTPQVDWNKIGGD--LPKGRETKE--NYGKTLKIENVSYQDKGNYRCTASNF 331
L C + G P P V W K D +P + + TL + V +D G Y CTA+N
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 332 LGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGE 373
G T +++V+ PP +P+ V T ++ I L G+
Sbjct: 1429 GGFDTIIVNLLVQVPP---DQPRLTVSKTSASSITLTWIPGD 1467
Score = 40.0 bits (92), Expect = 0.014
Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 11/88 (12%)
Query: 459 LHCEFFASPEAVVSWQKVEEVKPL----EGRRYHIYENGTLQINRTTEEDAGSYSCWVEN 514
L C P V W K E + +G R I+ NGTL + ED+G Y+C N
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL-IHTNGTLLLRAVKAEDSGYYTCTATN 1427
Query: 515 AIGKTAVTANLDIRNATKLRVSPKNPRI 542
G + NL ++V P PR+
Sbjct: 1428 TGGFDTIIVNL------LVQVPPDQPRL 1449
Score = 38.5 bits (88), Expect = 0.040
Identities = 219/1083 (20%), Positives = 362/1083 (33%), Gaps = 185/1083 (17%)
Query: 33 QVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPT-FSWTKDGNPFYFTDHRIIPSNNSGT 91
+VP +I+ + A + I C P +W KDG I S +
Sbjct: 654 KVPPLIQPFEFPPA-SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS 712
Query: 92 FRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVL 151
+ + H G Y C ASN +S E + IV P+F + + + G VL
Sbjct: 713 SLQISSVSLKH-NGNYTCIASNAAA-TVSRERQLIVRVPPRFVVQPNNQDGIY-GKAGVL 769
Query: 152 PCNPPKGLPPLHIYWMNI-------ELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCC 204
C+ G PP + W + + + R+ + L +V E+D Y C
Sbjct: 770 NCSVD-GYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDI-GYYLC 827
Query: 205 FAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSES 264
A+ + T+I SK+ + + P ++ S
Sbjct: 828 QAS-------------------------NGVGTDI-SKSMFLTVKIPAMIT------SHP 855
Query: 265 SITI-LKGEILLLECFAEGLPTPQVDWNKIGGDLPKGR------ETKENYGK---TLKIE 314
+ TI +KG L C A G + W K + R TK+N + TLK++
Sbjct: 856 NTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLK 915
Query: 315 NVSYQDKGNYRCTASNFLGTATHDFHVIVEEPP-----------------RWTKKPQSAV 357
D + C A N G + V+EPP RWT++
Sbjct: 916 PADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNS 975
Query: 358 YSTG--------SNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNL-- 407
TG S+ ++ PTI + VD HP V R SF +
Sbjct: 976 IITGFDIEYKNKSDSWDFKQSTRNISPTIN---QANIVDLHP--ASVYSIRMYSFNKIGR 1030
Query: 408 -QPNHTAVYQCEASNVHGTIL-------ANANIDVVDVRPLIQTKDGENYATVVGYSAFL 459
+P+ E + G + + +I V P + ++G +GY
Sbjct: 1031 SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGY---- 1086
Query: 460 HCEFFASPEAVVSWQKVEEVKPLEGRRYHIYE-NGTLQINRTTEEDAGSYSCW--VENAI 516
E P +Y I E T T ++ ++ + V A
Sbjct: 1087 -----------------RENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAF 1129
Query: 517 GKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFE 576
+ + NAT L P P + L + + +SWS+ +
Sbjct: 1130 NRAGTGPSSSEINATTLEDVPSQPP-ENVRALSITSDVAV---------ISWSEPPRS-T 1178
Query: 577 INGTEDG-RII-----IDGA-----NLTISNVTLEDQGIYCCSAHT----ALDSAADITQ 621
+NG G R+I +DG N+T + +E +G+ + ++ A A D +
Sbjct: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238
Query: 622 VTVL------DVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRW 675
+VL DVP PP + SV ++W N I +Y +
Sbjct: 1239 SSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP 1298
Query: 676 EELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIR 735
E + I L +Y V AV GR S+ A
Sbjct: 1299 SEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGT 1358
Query: 736 VQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYA 795
V K++ + P S+ P +++ + PV + + + ++ AV A
Sbjct: 1359 VTTPWMKDVRL---PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKA 1415
Query: 796 PYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVH 855
G D V L P P + V +++ + +TW +P D
Sbjct: 1416 EDSGYYTCTATNTGGFDTIIVNLLV--QVPPDQPRLT-VSKTSASSITLTW--IPGDNGG 1470
Query: 856 GRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKG 915
++G+ + + +D K+V I S S + SL + + + + A NS G
Sbjct: 1471 SSIRGFVLQY-----SVDNSEEWKDVFI---SSSERSFKLDSLKCGTWYKVKLAAKNSVG 1522
Query: 916 AGPESEPYIFQT----PEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGN--LTGYLLQY 969
+G SE +T P +Q F + W NG +T +L+Y
Sbjct: 1523 SGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWN-----NGGCPITAIVLEY 1577
Query: 970 QIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLG 1029
+ G + S L+ L T Y+ +RAC S GCG + ++
Sbjct: 1578 R------PKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDY 1631
Query: 1030 EGS 1032
+GS
Sbjct: 1632 DGS 1634
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 197 bits (502), Expect = 4e-50
Identities = 197/799 (24%), Positives = 329/799 (41%), Gaps = 76/799 (9%)
Query: 269 LKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENY--GKTLKIENVSYQ-----DK 321
++G ++L C A P+P+++W K G L + + +L I NV + D+
Sbjct: 65 VRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDE 124
Query: 322 GNYRCTAS-NFLGTA-THDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIK 379
G Y+C A+ LGT + +IV PR+T +P+ + G+N IL CE + P ++
Sbjct: 125 GYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVR 184
Query: 380 WRVNGSPVDNHPFAGDVVFPRE---ISFTNLQPNHTAVYQCEASN---------VHGTIL 427
W N P+ D V + +N +Y+C + V +L
Sbjct: 185 WEQNRQPL----LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 240
Query: 428 ANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEG-RR 486
+ + + L+ K V+G L C P + W K EE E R
Sbjct: 241 PDPEV----ISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSER 296
Query: 487 YHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLH 546
+ G+L+I+ TE+DAG+Y C +N A L ++ + P N +
Sbjct: 297 LVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESM 356
Query: 547 MLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYC 606
+ CE K + + W K+G+ D I+ NL + + D+G Y
Sbjct: 357 DIVFECEVTG----KPTPTVKWVKNGDMVI---PSDYFKIVKEHNLQVLGLVKSDEGFYQ 409
Query: 607 CSAHTALDSAADITQVTVLD--------VPDPPENLHLSERQNRSVRLTWEAGAD--HNS 656
C A + +A Q+ +L+ +P P ++ S R ++LTW A H
Sbjct: 410 CIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGD 469
Query: 657 NISEYIVEFEGNKEEPGRWE-ELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQ 715
N++ Y V + KE R E T G+ I L P Y FRV+A N+ G + S
Sbjct: 470 NLT-YSVFY--TKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526
Query: 716 PSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVE 775
P P N+R A+ P + + WE + NG Y++ + +G E
Sbjct: 527 PLRVETQPEVQLPGPAPNLRAYAASPTSITVTWET--PVSGNGEIQNYKLYYMEKGTDKE 584
Query: 776 WEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVD 835
++ V++H+ + Y Y +V A N+ G G V + + D P AP ++
Sbjct: 585 -QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLE 643
Query: 836 VINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMV 895
V NS + + W +G++ GY+I + K + +V SG + S ++
Sbjct: 644 VRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA-------SRKSDVTETLVSGTQLSQLI 696
Query: 896 PSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEG------VPEQPTFLKVIKVDKDTAT 949
LD +E++ V A G GP ++ +T E VPE P+ L V + +
Sbjct: 697 EGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIV 755
Query: 950 LSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LSNLNATTKYKFY 1008
+SW P+ N + GY + Y IG + I K ++ + NL+ ++ Y
Sbjct: 756 VSWTPPENQNIVVRGYAI-------GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVIT 808
Query: 1009 LRACTSQGCGKPITEESST 1027
L+A + G G P+ E + T
Sbjct: 809 LKAFNNVGEGIPLYESAVT 827
Score = 135 bits (340), Expect = 2e-31
Identities = 222/1040 (21%), Positives = 397/1040 (38%), Gaps = 137/1040 (13%)
Query: 55 IECEAKGNPEPTFSWTKDG---NPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFA 111
+ C A P P W KDG N +++P + + + H +G Y+C A
Sbjct: 72 LNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVA 131
Query: 112 S-NKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIE 170
+ LG +S + IV +P+F + +P V G+ +L C L P + W
Sbjct: 132 TVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGNNAILNCEVNADLVPF-VRWEQ-N 188
Query: 171 LEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHA 230
+ + D+RV G L +N E D Y C ++ +K+
Sbjct: 189 RQPLLLDDRVIKLPSGMLVISNATEGDG-GLYRCVVESGGPPKYSDEVELKVL------- 240
Query: 231 NDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDW 290
E+ S +KQ P + + G+ ++L C A GLPTP + W
Sbjct: 241 ----PDPEVISDLVFLKQPSP--------------LVRVIGQDVVLPCVASGLPTPTIKW 282
Query: 291 --NKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPR 348
N+ D G +L+I +V+ D G Y C A N T + V+ P
Sbjct: 283 MKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPE 342
Query: 349 WTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQ 408
+ K+P + + + CE G+P PT+KW NG V + +V + L
Sbjct: 343 FLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYF-KIVKEHNLQVLGLV 401
Query: 409 PNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 468
+ YQC A N G A A + +++ P VV ++ + F
Sbjct: 402 KSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVV--ASLVSTRFIK--- 456
Query: 469 AVVSWQKVEEVKPLEGRRYHIY--ENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLD 526
++W+ + Y ++ + G + G ++N + T +
Sbjct: 457 --LTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVM 514
Query: 527 IRN-------ATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSW----SKDGEA- 574
+N + LRV + P++ + + + S+ ++W S +GE
Sbjct: 515 AQNKHGSGESSAPLRVETQ----PEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQ 570
Query: 575 ------FEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP 628
E ++ + + + TI+ + + + A+ V V +
Sbjct: 571 NYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 630
Query: 629 DPP----ENLHLSERQNRSVRLTWE--AGADHNSNISEYIVEFEGNKEEPGRWEELTRVQ 682
D P +NL L R ++S+ + W+ A A N I+ Y + + + E T V
Sbjct: 631 DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE--TLVS 688
Query: 683 GKKTTVILP-LAPFVRYQFRVIA--VNEVG-----RSQPSQPSDHHETPPAAPDRNPQNI 734
G + + ++ L Y FRV A +N G S + SD ET P+ P ++
Sbjct: 689 GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDET--RVPE-VPSSL 745
Query: 735 RVQASQPKEMIIKWEPLKSME--QNGPGLEYRV-TWKPQGAPVEWEEETVTNHTLRVMTP 791
V+ +++ W P ++ G + Y + + Q V++++ +T+ + P
Sbjct: 746 HVR-PLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQR---YYTIENLDP 801
Query: 792 AVYAPYDVKVQAINQLGSG------------PDPQSVTLY----SGEDYPDTAPVIHGVD 835
+ + Y + ++A N +G G D V L+ PD P++ V
Sbjct: 802 SSH--YVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVG 859
Query: 836 VINSTL----VKVTW--STVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889
V S L +++TW +++PK + + Y + W K+ + T K N
Sbjct: 860 VQASILSHDTIRITWADNSLPKHQKITDSRYYTVRW---KTNIPANTKYKNANATTL--- 913
Query: 890 RNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKD--- 946
S +V L + + +V+ + + S T E VP P V V K+
Sbjct: 914 --SYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPP-KDVTVVSKEGKP 970
Query: 947 -TATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELND--INITTPSKPSWHLSNLNATT 1003
T ++W P + NG +TGY++ Y T E++D I ++ + + L T
Sbjct: 971 KTIIVNWQPPSEANGKITGYIIYY----STDVNAEIHDWVIEPVVGNRLTHQIQELTLDT 1026
Query: 1004 KYKFYLRACTSQGCGKPITE 1023
Y F ++A S+G G P++E
Sbjct: 1027 PYYFKIQARNSKGMG-PMSE 1045
Score = 120 bits (301), Expect = 8e-27
Identities = 167/699 (23%), Positives = 287/699 (41%), Gaps = 61/699 (8%)
Query: 352 KPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPV-----DNHPFAGD-VVFPREISFT 405
+P + GS+ IL C A EP P I+W+ +G+ + D D +F + +
Sbjct: 58 EPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHS 117
Query: 406 NLQPNHTAVYQCEAS-NVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFF 464
YQC A+ GTI++ +V P T E + G +A L+CE
Sbjct: 118 KHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRF-TSQPEPSSVYAGNNAILNCEVN 176
Query: 465 ASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTAN 524
A V W++ + L+ R + +G L I+ TE D G Y C VE+ G +
Sbjct: 177 ADLVPFVRWEQNRQPLLLDDRVIKL-PSGMLVISNATEGDGGLYRCVVESG-GPPKYSDE 234
Query: 525 LDIR-----NATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEING 579
++++ V K P P + ++ C + + + W K+ EA +
Sbjct: 235 VELKVLPDPEVISDLVFLKQPS-PLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
Query: 580 TEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPD---PPENLHL 636
+E +++ G +L IS+VT +D G Y C A ++ ++TV P+ P N++
Sbjct: 294 SE-RLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYA 352
Query: 637 SERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFV 696
E S+ + +E + V+ G+ P + ++ + + +L L
Sbjct: 353 HE----SMDIVFECEVTGKPTPTVKWVK-NGDMVIPSDYFKIVK---EHNLQVLGLVKSD 404
Query: 697 RYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIR-VQASQPKEMIIK--WEPLKS 753
++ IA N+VG +Q E PA P R V AS IK W S
Sbjct: 405 EGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPAS 464
Query: 754 MEQNGPGLEYRVTWKPQGAPVEWEEET----VTNHTLRVMTPAVYAPYDVKVQAINQLGS 809
+ +G L Y V + +G E E T T++ + PA Y +V A N+ GS
Sbjct: 465 -DPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATV--YIFRVMAQNKHGS 521
Query: 810 GPD--PQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWK 867
G P V P AP + + T + VTW T +G ++ Y++ + +
Sbjct: 522 GESSAPLRVETQPEVQLPGPAPNLRAY-AASPTSITVTWETPVSG--NGEIQNYKLYYME 578
Query: 868 TKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQT 927
G ++V++ +S + L ++E+ V+AYN G G + +T
Sbjct: 579 -----KGTDKEQDVDV-----SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT 628
Query: 928 PEGVPE-QPTFLKVIKVDKDTATLSW--GLPKKLNGNLTGYLLQYQIINDTYEIGELNDI 984
VP P L + + + + W P NG +TGY ++Y+ + ++ E
Sbjct: 629 LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE---- 684
Query: 985 NITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITE 1023
+ + ++ S + L+ T+Y F + A T G G P T+
Sbjct: 685 TLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTG-PATD 722
Score = 90.5 bits (223), Expect = 9e-18
Identities = 212/980 (21%), Positives = 349/980 (35%), Gaps = 202/980 (20%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRI-IPSNNSGTFRIPN--EGHISHFQGKYRCFA 111
+ CE + P W ++ P D I +PS G I N EG G YRC
Sbjct: 171 LNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPS---GMLVISNATEGD----GGLYRCVV 223
Query: 112 SNKLGIAMSEEIEFIVPSVPKFPKEKI-----DPLEVEEGDPIVLPCNPPKGLPPLHIYW 166
+ S+E+E V P+ + + PL G +VLPC GLP I W
Sbjct: 224 ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKW 282
Query: 167 M-NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVN 225
M N E E ER+ + G L ++V E D+ Y C A
Sbjct: 283 MKNEEALDTESSERLVLLAGGSLEISDVTEDDA-GTYFCIA------------------- 322
Query: 226 SLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPT 285
D+ + T I ++A Q +P+ L PT + S+ I + EC G PT
Sbjct: 323 ------DNGNET-IEAQAELTVQAQPEFLKQPTNIYAHESMDI------VFECEVTGKPT 369
Query: 286 PQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFH-VIVE 344
P V W K G + K L++ + D+G Y+C A N +G A +I+E
Sbjct: 370 PTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILE 429
Query: 345 EPPRWT----KKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPR 400
P T P+ V S S + + WR S V + +
Sbjct: 430 HAPATTGPLPSAPRDVVASLVSTRFI----------KLTWRTPASDPHGDNLTYSVFYTK 479
Query: 401 E-----------------ISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQT 443
E ++ NL P +++ A N HG+ ++A + V+ +P +Q
Sbjct: 480 EGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLR-VETQPEVQ- 537
Query: 444 KDGENYATVVGYSAFLHCEFFASPEAV-VSWQ-KVEEVKPLEGRRYHIYENGTLQINRTT 501
+ G + L + ASP ++ V+W+ V ++ + + E GT ++
Sbjct: 538 --------LPGPAPNLRA-YAASPTSITVTWETPVSGNGEIQNYKLYYMEKGT---DKEQ 585
Query: 502 EEDAGSYSCWVE---------------NAIGKTAVTANLDIRNATKL-RVSPKN--PRIP 543
+ D S+S + N G T ++ +R + + +P+N +
Sbjct: 586 DVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVR 645
Query: 544 KLHMLELHCESKCDSHLKHSL--------KLSWSKDGEAFEINGTEDGRII--IDGA--- 590
+ +H + + + K S D ++GT+ ++I +D
Sbjct: 646 NSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEY 705
Query: 591 NLTISNVTLEDQG--IYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTW 648
N ++ +T+ G SA T +S D T+ VP+ P +LH+ S+ ++W
Sbjct: 706 NFRVAALTINGTGPATDWLSAET-FESDLDETR-----VPEVPSSLHVRPLVT-SIVVSW 758
Query: 649 EAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGK-KTTVILPLAPFVRYQFRVIAVNE 707
+ N + Y + + + +V K + I L P Y + A N
Sbjct: 759 TPPENQNIVVRGYAIGYGIGSPH----AQTIKVDYKQRYYTIENLDPSSHYVITLKAFNN 814
Query: 708 VGRSQPSQPS----DHHET---------------PPAAPDRNPQNIRVQASQPKEMIIKW 748
VG P S H +T P P P ++ + I W
Sbjct: 815 VGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITW 874
Query: 749 --EPLKSMEQNGPGLEYRVTWK---PQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQ- 802
L ++ Y V WK P + T ++ + + P + V V
Sbjct: 875 ADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTK 934
Query: 803 -------------AINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTV 849
+L P+ VT+ S E P T + V W
Sbjct: 935 GRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKT--------------IIVNWQ-- 978
Query: 850 PKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVL 909
P +G++ GY I ++ T D + I G R + + L + ++ +
Sbjct: 979 PPSEANGKITGY-IIYYST----DVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQ 1033
Query: 910 AYNSKGAGPESEPYIFQTPE 929
A NSKG GP SE F+TP+
Sbjct: 1034 ARNSKGMGPMSEAVQFRTPK 1053
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/104 (28%), Positives = 47/104 (45%), Gaps = 9/104 (8%)
Query: 30 SVQQVPTIIKQ-SKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDH-RIIPSN 87
+VQ P +KQ + + D F ECE G P PT W K+G+ +D+ +I+ +
Sbjct: 336 TVQAQPEFLKQPTNIYAHESMDIVF--ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH 393
Query: 88 NSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVP 131
N G + +G Y+C A N +G A + I+ P
Sbjct: 394 NLQVL-----GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 196 bits (497), Expect = 1e-49
Identities = 204/826 (24%), Positives = 327/826 (39%), Gaps = 121/826 (14%)
Query: 10 LIVYLMFLLLKFSKAIEIPSSVQQ--VPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTF 67
L+++ LL F S ++Q P I + V E + C+A+G P PT
Sbjct: 3 LLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTI 62
Query: 68 SWTKDGNPFYFTD------HR-IIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMS 120
W KDG TD HR ++PS + RI + +G Y C A N LG A+S
Sbjct: 63 EWYKDGERVE-TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVS 121
Query: 121 EEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERV 180
V + ++ + V G+P +L C PP+G P IYW ++ +++ER+
Sbjct: 122 RNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERI 181
Query: 181 YMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIG 240
+ + G L +N + D+ C R P +LTV
Sbjct: 182 SI-RGGKLMISNTRKSDAGMYTCVGTNMVGER---DSDPAELTV---------------- 221
Query: 241 SKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKG 300
+P L P +L+ E + C +G P P V W K DLP+G
Sbjct: 222 -------FERPTFLRRPINQ------VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG 268
Query: 301 R-ETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYS 359
R + K++Y TL+I+ D+G Y C A N +G + V PP++ +P+ + +
Sbjct: 269 RYDIKDDY--TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
Query: 360 TGSNGILLCEAEGEPQPTIKWRVNGSP------VDNHPFAGDVVFPR-EISFTNLQPNHT 412
G CE +G PQP + W+ GS P + V P +++ TN+Q +
Sbjct: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 386
Query: 413 AVYQCEASNVHGTILANANIDVVDV----RPLIQTKDGENYATVVGYSAFLHCEFFASPE 468
Y C+A V G+ILA A ++V DV P I + N V +A L C+ P
Sbjct: 387 GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 446
Query: 469 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR 528
V+SW K P R I E GTLQI D G+Y+C ++ G+T+ +A LD+
Sbjct: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
Query: 529 NA----------TKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDG------ 572
+ + L P P++ + K+S+ LSW
Sbjct: 507 ESGATISKNYDLSDLPGPPSKPQVTDV--------------TKNSVTLSWQPGTPGTLPA 552
Query: 573 -----EAFEINGTEDGRIIIDGANLTISNVT-LEDQGIY-----CCSAHTALDSAADITQ 621
EAF + + + + + T+ V L IY + D +
Sbjct: 553 SAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 612
Query: 622 VTVLDVPDPPENLHLSERQNR-----------------SVRLTWEAGADHNSNISEYIVE 664
V D+ P + + + Q +V++TW I Y V
Sbjct: 613 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQF-IQGYRVM 671
Query: 665 FE--GNKEEPGRWEEL-TRVQGKKTTVILPLAPFVRYQFRVIA-VNEV-GRSQPSQPSDH 719
+ + W+ L +V +++ V++ L V Y+ +V NE G S+
Sbjct: 672 YRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRT 731
Query: 720 HETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
E P+AP ++ + V + + + W+P QNG EY++
Sbjct: 732 TEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 777
Score = 167 bits (422), Expect = 7e-41
Identities = 195/856 (22%), Positives = 317/856 (37%), Gaps = 119/856 (13%)
Query: 128 PSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQK-- 185
P + + P + I V +G+P L C +G P I W + E +E D+ S +
Sbjct: 31 PRIVEHPSDVI----VSKGEPTTLNCKA-EGRPTPTIEWYK-DGERVETDKDDPRSHRML 84
Query: 186 ---GDLYFANV----EEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTE 238
G L+F + K Y C A N L A ++S E
Sbjct: 85 LPSGSLFFLRIVHGRRSKPDEGSYVCVAR-----------------NYLGEAVSRNASLE 127
Query: 239 IGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFA-EGLPTPQVDWNKIGGDL 297
+ + +Q PT+ + + GE +LEC G P P + W K +
Sbjct: 128 VALLRDDFRQN-------PTD------VVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI 174
Query: 298 PKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHD-FHVIVEEPPRWTKKPQSA 356
E G L I N D G Y C +N +G D + V E P + ++P +
Sbjct: 175 DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQ 234
Query: 357 VYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQ 416
V C+ +G+PQPT++W+ + + + + D+ + Y
Sbjct: 235 VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRY--DIKDDYTLRIKKTMSTDEGTYM 292
Query: 417 CEASNVHGTILANANIDV-VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQK 475
C A N G + A+A + V + +++ +D G + CE +P+ V WQK
Sbjct: 293 CIAENRVGKMEASATLTVRAPPQFVVRPRD---QIVAQGRTVTFPCETKGNPQPAVFWQK 349
Query: 476 VEEVKPL-------EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR 528
L R + G L I DAG Y C G A L++
Sbjct: 350 EGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT 409
Query: 529 NATKLRVSPKNPRIPKLHMLELHCES--KCDSHLKHSLKLSWSKDGEAFEINGTEDGRII 586
+ R P + P L + + KC + +SW K+G F G + I
Sbjct: 410 DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG--FTFPGRDPRATI 467
Query: 587 IDGANLTISNVTLEDQGIYCC-----SAHTALDSAADITQ--------VTVLDVPDPPEN 633
+ L I N+ + D G Y C S T+ + D+T+ + D+P PP
Sbjct: 468 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSK 527
Query: 634 LHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLA 693
+++ SV L+W+ G S YI+E ++ W+ + + L
Sbjct: 528 PQVTDVTKNSVTLSWQPGTPGTLPASAYIIE-AFSQSVSNSWQTVANHVKTTLYTVRGLR 586
Query: 694 PFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ------------- 740
P Y F V A+N G S PS SD T +P + R +
Sbjct: 587 PNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVV 646
Query: 741 --PKEMIIKW---------EPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVM 789
P + + W + + M + GL+ +W+ A V E V + + +
Sbjct: 647 LTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGV 706
Query: 790 TPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP---VIHGVDVINSTLVKVTW 846
T Y++KV+ G D +S T+ + E+ P P + V NST + V+W
Sbjct: 707 T------YEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSW 760
Query: 847 STVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHL 906
P D +G ++ Y+I W + + R H + G+ P + ++ +
Sbjct: 761 DPPPPDHQNGIIQEYKI--WCLGN--ETRFHINKTVDAAIRSVIIGGLFPGI----QYRV 812
Query: 907 TVLAYNSKGAGPESEP 922
V A S G G +SEP
Sbjct: 813 EVAASTSAGVGVKSEP 828
Score = 145 bits (365), Expect = 3e-34
Identities = 195/823 (23%), Positives = 322/823 (39%), Gaps = 89/823 (10%)
Query: 256 PPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIEN 315
PP S + + KGE L C AEG PTP ++W K G + ++ ++ L +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 316 V----------SYQDKGNYRCTASNFLGTATHDFHVIVEEPPR--WTKKPQSAVYSTGSN 363
+ S D+G+Y C A N+LG A + R + + P V + G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
Query: 364 GILLCEA-EGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNV 422
IL C+ G P+PTI W+ + +D+ + + + +N + + +Y C +N+
Sbjct: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNM 208
Query: 423 HGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
G ++ V RP + N + + C+ P+ V W+K + P
Sbjct: 209 VGERDSDPAELTVFERPTFLRRP-INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
Query: 483 EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRI 542
RY I ++ TL+I +T D G+Y C EN +GK +A L +R + V P++ +
Sbjct: 268 G--RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
Query: 543 PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGR-----IIIDGANLTISNV 597
+ + CE+K + + W K+G + + + + +LTI+N+
Sbjct: 326 AQGRTVTFPCETKGNP----QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV---PDPPENLHLSERQNRSVRLTWEAGADH 654
D G Y C A T S Q+ V DV PP L Q +V T
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Query: 655 NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS 714
+ I + PGR T +Q + T I L + +A + G + S
Sbjct: 442 TGDPLPVISWLKEGFTFPGRDPRAT-IQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
Query: 715 QPSDHHETPPAAPDRN---------PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
D E+ A +N P +V + + W+P P Y +
Sbjct: 501 AVLDVTES-GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQP--GTPGTLPASAYII 557
Query: 766 TWKPQGAPVEWEEETVTNH------TLRVMTPAVYAPYDVKVQAINQLG-SGPDPQSVTL 818
Q W +TV NH T+R + P Y V+AIN G S P P S +
Sbjct: 558 EAFSQSVSNSW--QTVANHVKTTLYTVRGLRPNTI--YLFMVRAINPQGLSDPSPMSDPV 613
Query: 819 YSGEDYP---------------DTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQI 863
+ + P D +H V+ T V+VTW+ DR ++GY++
Sbjct: 614 RTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTV---DRQPQFIQGYRV 670
Query: 864 NWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPY 923
+ +T L + N+ S ++ +L + + V Y ++ G +SE
Sbjct: 671 MYRQTSGL---QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK 727
Query: 924 IFQTPEGVPEQP----TFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQII---NDT- 975
+T E P P T L V + + ++SW P + N G + +Y+I N+T
Sbjct: 728 TVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN--GIIQEYKIWCLGNETR 785
Query: 976 YEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCG 1018
+ I + D I S + L +Y+ + A TS G G
Sbjct: 786 FHINKTVDAAIR-----SVIIGGLFPGIQYRVEVAASTSAGVG 823
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 195 bits (496), Expect = 2e-49
Identities = 194/779 (24%), Positives = 311/779 (39%), Gaps = 119/779 (15%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTD------HR-IIPSNNSGTFRIPNEGHISHFQGKY 107
+ C+A+G P PT W KDG TD HR ++PS + RI + +G Y
Sbjct: 66 LNCKAEGRPTPTIEWYKDGERVE-TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSY 124
Query: 108 RCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM 167
C A N LG A+S V + ++ + V G+P +L C PP+G P IYW
Sbjct: 125 VCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK 184
Query: 168 NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSL 227
++ +++ER+ + + G L +N + D+ C R P +LTV
Sbjct: 185 KDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTCVGTNMVGER---DSDPAELTV--- 237
Query: 228 KHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQ 287
+P L P +L+ E + C +G P P
Sbjct: 238 --------------------FERPTFLRRPINQ------VVLEEEAVEFRCQVQGDPQPT 271
Query: 288 VDWNKIGGDLPKGR-ETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEP 346
V W K DLP+GR + K++Y TL+I+ D+G Y C A N +G + V P
Sbjct: 272 VRWKKDDADLPRGRYDIKDDY--TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329
Query: 347 PRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSP------VDNHPFAGDVVFPR 400
P++ +P+ + + G CE +G PQP + W+ GS P + V P
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 401 -EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDV----RPLIQTKDGENYATVVGY 455
+++ TN+Q + Y C+A V G+ILA A ++V DV P I + N V
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 449
Query: 456 SAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENA 515
+A L C+ P V+SW K P R I E GTLQI D G+Y+C ++
Sbjct: 450 TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 509
Query: 516 IGKTAVTANLDIRNA----------TKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLK 565
G+T+ +A LD+ + + L P P++ + K+S+
Sbjct: 510 SGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV--------------TKNSVT 555
Query: 566 LSWSKDG-----------EAFEINGTEDGRIIIDGANLTISNVT-LEDQGIY-----CCS 608
LSW EAF + + + + + T+ V L IY +
Sbjct: 556 LSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAIN 615
Query: 609 AHTALDSAADITQVTVLDVPDPPENLHLSERQNR-----------------SVRLTWEAG 651
D + V D+ P + + + Q +V++TW
Sbjct: 616 PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD 675
Query: 652 ADHNSNISEYIVEFE--GNKEEPGRWEEL-TRVQGKKTTVILPLAPFVRYQFRVIA-VNE 707
I Y V + + W+ L +V +++ V++ L V Y+ +V NE
Sbjct: 676 RQPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNE 734
Query: 708 V-GRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
G S+ E P+AP ++ + V + + + W+P QNG EY++
Sbjct: 735 FQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 793
Score = 167 bits (422), Expect = 7e-41
Identities = 195/856 (22%), Positives = 317/856 (37%), Gaps = 119/856 (13%)
Query: 128 PSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQK-- 185
P + + P + I V +G+P L C +G P I W + E +E D+ S +
Sbjct: 47 PRIVEHPSDVI----VSKGEPTTLNCKA-EGRPTPTIEWYK-DGERVETDKDDPRSHRML 100
Query: 186 ---GDLYFANV----EEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTE 238
G L+F + K Y C A N L A ++S E
Sbjct: 101 LPSGSLFFLRIVHGRRSKPDEGSYVCVAR-----------------NYLGEAVSRNASLE 143
Query: 239 IGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFA-EGLPTPQVDWNKIGGDL 297
+ + +Q PT+ + + GE +LEC G P P + W K +
Sbjct: 144 VALLRDDFRQN-------PTD------VVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI 190
Query: 298 PKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHD-FHVIVEEPPRWTKKPQSA 356
E G L I N D G Y C +N +G D + V E P + ++P +
Sbjct: 191 DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQ 250
Query: 357 VYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQ 416
V C+ +G+PQPT++W+ + + + + D+ + Y
Sbjct: 251 VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRY--DIKDDYTLRIKKTMSTDEGTYM 308
Query: 417 CEASNVHGTILANANIDV-VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQK 475
C A N G + A+A + V + +++ +D G + CE +P+ V WQK
Sbjct: 309 CIAENRVGKMEASATLTVRAPPQFVVRPRD---QIVAQGRTVTFPCETKGNPQPAVFWQK 365
Query: 476 VEEVKPL-------EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR 528
L R + G L I DAG Y C G A L++
Sbjct: 366 EGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT 425
Query: 529 NATKLRVSPKNPRIPKLHMLELHCES--KCDSHLKHSLKLSWSKDGEAFEINGTEDGRII 586
+ R P + P L + + KC + +SW K+G F G + I
Sbjct: 426 DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG--FTFPGRDPRATI 483
Query: 587 IDGANLTISNVTLEDQGIYCC-----SAHTALDSAADITQ--------VTVLDVPDPPEN 633
+ L I N+ + D G Y C S T+ + D+T+ + D+P PP
Sbjct: 484 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSK 543
Query: 634 LHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLA 693
+++ SV L+W+ G S YI+E ++ W+ + + L
Sbjct: 544 PQVTDVTKNSVTLSWQPGTPGTLPASAYIIE-AFSQSVSNSWQTVANHVKTTLYTVRGLR 602
Query: 694 PFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ------------- 740
P Y F V A+N G S PS SD T +P + R +
Sbjct: 603 PNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVV 662
Query: 741 --PKEMIIKW---------EPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVM 789
P + + W + + M + GL+ +W+ A V E V + + +
Sbjct: 663 LTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGV 722
Query: 790 TPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP---VIHGVDVINSTLVKVTW 846
T Y++KV+ G D +S T+ + E+ P P + V NST + V+W
Sbjct: 723 T------YEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSW 776
Query: 847 STVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHL 906
P D +G ++ Y+I W + + R H + G+ P + ++ +
Sbjct: 777 DPPPPDHQNGIIQEYKI--WCLGN--ETRFHINKTVDAAIRSVIIGGLFPGI----QYRV 828
Query: 907 TVLAYNSKGAGPESEP 922
V A S G G +SEP
Sbjct: 829 EVAASTSAGVGVKSEP 844
Score = 145 bits (365), Expect = 3e-34
Identities = 195/823 (23%), Positives = 322/823 (39%), Gaps = 89/823 (10%)
Query: 256 PPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIEN 315
PP S + + KGE L C AEG PTP ++W K G + ++ ++ L +
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 316 V----------SYQDKGNYRCTASNFLGTATHDFHVIVEEPPR--WTKKPQSAVYSTGSN 363
+ S D+G+Y C A N+LG A + R + + P V + G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 165
Query: 364 GILLCEA-EGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNV 422
IL C+ G P+PTI W+ + +D+ + + + +N + + +Y C +N+
Sbjct: 166 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNM 224
Query: 423 HGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
G ++ V RP + N + + C+ P+ V W+K + P
Sbjct: 225 VGERDSDPAELTVFERPTFLRRP-INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 283
Query: 483 EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRI 542
RY I ++ TL+I +T D G+Y C EN +GK +A L +R + V P++ +
Sbjct: 284 G--RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 341
Query: 543 PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGR-----IIIDGANLTISNV 597
+ + CE+K + + W K+G + + + + +LTI+N+
Sbjct: 342 AQGRTVTFPCETKGNP----QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV---PDPPENLHLSERQNRSVRLTWEAGADH 654
D G Y C A T S Q+ V DV PP L Q +V T
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 457
Query: 655 NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS 714
+ I + PGR T +Q + T I L + +A + G + S
Sbjct: 458 TGDPLPVISWLKEGFTFPGRDPRAT-IQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 516
Query: 715 QPSDHHETPPAAPDRN---------PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRV 765
D E+ A +N P +V + + W+P P Y +
Sbjct: 517 AVLDVTES-GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQP--GTPGTLPASAYII 573
Query: 766 TWKPQGAPVEWEEETVTNH------TLRVMTPAVYAPYDVKVQAINQLG-SGPDPQSVTL 818
Q W +TV NH T+R + P Y V+AIN G S P P S +
Sbjct: 574 EAFSQSVSNSW--QTVANHVKTTLYTVRGLRPNTI--YLFMVRAINPQGLSDPSPMSDPV 629
Query: 819 YSGEDYP---------------DTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQI 863
+ + P D +H V+ T V+VTW+ DR ++GY++
Sbjct: 630 RTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTV---DRQPQFIQGYRV 686
Query: 864 NWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPY 923
+ +T L + N+ S ++ +L + + V Y ++ G +SE
Sbjct: 687 MYRQTSGL---QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK 743
Query: 924 IFQTPEGVPEQP----TFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQII---NDT- 975
+T E P P T L V + + ++SW P + N G + +Y+I N+T
Sbjct: 744 TVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN--GIIQEYKIWCLGNETR 801
Query: 976 YEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCG 1018
+ I + D I S + L +Y+ + A TS G G
Sbjct: 802 FHINKTVDAAIR-----SVIIGGLFPGIQYRVEVAASTSAGVG 839
Score = 80.1 bits (196), Expect = 1e-14
Identities = 78/316 (24%), Positives = 135/316 (42%), Gaps = 52/316 (16%)
Query: 30 SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNS 89
+V + PT +++ QV +E + C+ +G+P+PT W KD + I +
Sbjct: 236 TVFERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDI---KDD 291
Query: 90 GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKF---PKEKIDPLEVEEG 146
T RI +S +G Y C A N++G M V + P+F P+++I V +G
Sbjct: 292 YTLRIKKT--MSTDEGTYMCIAENRVG-KMEASATLTVRAPPQFVVRPRDQI----VAQG 344
Query: 147 DPIVLPCNPPKGLPPLHIYWMNIELEHI-------EQDERVYMSQKGDLYFANVEEKDSR 199
+ PC KG P ++W +++ + + R +S GDL N++ D+
Sbjct: 345 RTVTFPCE-TKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA- 402
Query: 200 NDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTE 259
Y A +I+ K +++T + + R P ++L
Sbjct: 403 -GYYICQALTVAGSILAKAQLEVT--------------------DVLTDRPPPIILQ--- 438
Query: 260 SGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK--TLKIENVS 317
++ T+ LL+C A G P P + W K G P GR+ + + TL+I+N+
Sbjct: 439 --GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQIKNLR 495
Query: 318 YQDKGNYRCTASNFLG 333
D G Y C A++ G
Sbjct: 496 ISDTGTYTCVATSSSG 511
Score = 73.6 bits (179), Expect = 1e-12
Identities = 92/416 (22%), Positives = 156/416 (37%), Gaps = 62/416 (14%)
Query: 39 KQSKVQVAFPFDEYFQIECEA-KGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNE 97
+Q+ V E +EC+ +G+PEPT W KD + RI S G I N
Sbjct: 152 RQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERI--SIRGGKLMISNT 209
Query: 98 GHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPK 157
G Y C +N +G S+ E V P F + I+ + +EE + + C +
Sbjct: 210 RKSD--AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE-EAVEFRCQ-VQ 265
Query: 158 GLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQK 217
G P + W ++D+ DL + KD DY
Sbjct: 266 GDPQPTVRW--------KKDD-------ADLPRGRYDIKD---DY--------------T 293
Query: 218 MPMKLTVNSLKHANDSSSSTEIG---SKANSIKQRKPKLLLPPTESGSESSITILKGEIL 274
+ +K T+++ + + +G + A + P+ ++ P + + +G +
Sbjct: 294 LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ------IVAQGRTV 347
Query: 275 LLECFAEGLPTPQVDWNKIGG------DLPKGRETKENYGKT--LKIENVSYQDKGNYRC 326
C +G P P V W K G + P+ ++ + T L I N+ D G Y C
Sbjct: 348 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYIC 407
Query: 327 TASNFLGTATHDFHVIVEE------PPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKW 380
A G+ + V + PP + P + + +L C+A G+P P I W
Sbjct: 408 QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISW 467
Query: 381 RVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVD 436
G + + NL+ + T Y C A++ G +A +DV +
Sbjct: 468 LKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 523
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 184 bits (466), Expect = 6e-46
Identities = 203/828 (24%), Positives = 321/828 (38%), Gaps = 107/828 (12%)
Query: 55 IECEAKGNPEPTFSWTKDGNPFYFTD------HR-IIPSNNSGTFRIPNEGHISHFQGKY 107
+ C+A+G P PT W K G TD HR ++PS + RI + +G Y
Sbjct: 48 LNCKAEGRPTPTIEWYKGGERVE-TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106
Query: 108 RCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM 167
C A N LG A+S V + ++ + V G+P V+ C PP+G P I W
Sbjct: 107 VCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK 166
Query: 168 NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSL 227
++DER+ + +G K Y C
Sbjct: 167 KDGSPLDDKDERITI--RGGKLMITYTRKSDAGKYVCV---------------------- 202
Query: 228 KHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQ 287
+ +G + + + + +L P+ S++ + + +C A G P P
Sbjct: 203 -------GTNMVGERESEVAEL--TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 288 VDWNKIGGDLPKGR-ETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEP 346
V W K G+LPK R E ++++ TLKI V+ D G+Y C A N +G A + V+EP
Sbjct: 254 VRWRKDDGELPKSRYEIRDDH--TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 311
Query: 347 PRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGS---------PVDNHPFAGDVV 397
P + KP+ V + G CEA G PQP I WR GS P + F+ V
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS--VS 369
Query: 398 FPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDV---RPLIQTKDGE-NYATVV 453
+++ TN+Q + Y C+ NV G+I+ A ++V DV RP + G N V
Sbjct: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
Query: 454 GYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVE 513
+ L C SP + W+K + + R ENG LQI D G Y+C
Sbjct: 430 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
Query: 514 NAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD-- 571
G+ +A ++++ + V P P P L + + + ++++ LSW +
Sbjct: 490 TPSGEATWSAYIEVQE-FGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRNTVTLSWQPNLN 547
Query: 572 ---------GEAFEINGTEDGRIIIDGANLTISNVT-LEDQGIY-----CCSAHTALDSA 616
EAF + + + S + L+ IY +A+ D +
Sbjct: 548 SGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPS 607
Query: 617 ADITQVTVLDVPDPPEN--------------LHL---SERQNRSVRLTWEAGADHNSNIS 659
V DV + LHL + + S+ + W + I
Sbjct: 608 QISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQ 666
Query: 660 EYIVEFEGNKEEPGRWEEL---TRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQP 716
Y + + + G + L R K + VI L V Y+ + + S+
Sbjct: 667 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE- 725
Query: 717 SDHHETPPAAPDRNPQNIRVQASQPK--EMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPV 774
+T AP PQ + V + +++ W+P QNG EY+V W
Sbjct: 726 IKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WCLGNETR 784
Query: 775 EWEEETVTNHTLRVMTPAVY--APYDVKVQAINQLGSG--PDPQSVTL 818
+TV T V+ P + Y V+V A GSG +PQ + L
Sbjct: 785 YHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
Score = 155 bits (393), Expect = 2e-37
Identities = 188/867 (21%), Positives = 318/867 (36%), Gaps = 113/867 (13%)
Query: 128 PSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMN----IELEHIEQDERVYMS 183
P + + P + I V +G+P L C +G P I W +E + + +
Sbjct: 29 PRIVEHPSDLI----VSKGEPATLNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 184 QKGDLYFAN-VEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSK 242
G L+F V + SR D + R N L A ++S E+
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVAR--------------NYLGEAVSHNASLEVAIL 129
Query: 243 ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFA-EGLPTPQVDWNKIGGDLPKGR 301
+ +Q + S + + GE ++EC G P P + W K G L
Sbjct: 130 RDDFRQ-------------NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD 176
Query: 302 ETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDF-HVIVEEPPRWTKKPQSAVYST 360
E G L I D G Y C +N +G + + V E P + K+P + +
Sbjct: 177 ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 361 GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEAS 420
+ CEA G+P PT++WR + + + ++ + + Y C A
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDGELPKSRY--EIRDDHTLKIRKVTAGDMGSYTCVAE 294
Query: 421 NVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVK 480
N+ G A+A + V + + + +G + CE +P+ + W++
Sbjct: 295 NMVGKAEASATLTVQEPPHFVVKP--RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 352
Query: 481 -------PLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI------ 527
P R+ + + G L I D G Y C N G A L++
Sbjct: 353 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD 412
Query: 528 RNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRII- 586
R +R P N + L C + + W KDG + T+D RI
Sbjct: 413 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSP----VPTILWRKDGV---LVSTQDSRIKQ 465
Query: 587 IDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLD---------------VPDPP 631
++ L I L D G Y C A T A + V + +P P
Sbjct: 466 LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 525
Query: 632 ENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILP 691
+++ +V L+W+ + + + YI+E + W+ + +T+ I
Sbjct: 526 SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSS-WQTVAENVKTETSAIKG 584
Query: 692 LAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP-DRNPQNIRVQASQPKEMIIKWEP 750
L P Y F V A N G S PSQ SD +T P + + +VQ ++ P
Sbjct: 585 LKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNP 644
Query: 751 LK----------SMEQNGPGLE-YRVTWKPQGA---PVEW---EEETVTNHTLRVMTPAV 793
+++Q ++ Y++ ++P GA +W E T +++ +
Sbjct: 645 TVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRK 704
Query: 794 YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVI----NSTLVKVTWSTV 849
Y++K + G D + + E+ P P GV V N T + V+W
Sbjct: 705 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPP 762
Query: 850 PKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVL 909
P+D +G ++ Y++ W + + R H + G S ++P L + + V
Sbjct: 763 PEDTQNGMVQEYKV--WCLGN--ETRYHINKT----VDGSTFSVVIPFLVPGIRYSVEVA 814
Query: 910 AYNSKGAGPESEPYIFQ-TPEGVPEQP 935
A G+G +SEP Q G P P
Sbjct: 815 ASTGAGSGVKSEPQFIQLDAHGNPVSP 841
Score = 130 bits (326), Expect = 1e-29
Identities = 176/778 (22%), Positives = 301/778 (38%), Gaps = 91/778 (11%)
Query: 256 PPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIEN 315
PP S + + KGE L C AEG PTP ++W K G + ++ ++ L +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 316 V----------SYQDKGNYRCTASNFLGTA-THDFHVIVEE-PPRWTKKPQSAVYSTGSN 363
+ S D+G Y C A N+LG A +H+ + V + + P + + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 364 GILLCEA-EGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNV 422
++ C+ G P+PTI W+ +GSP+D+ + ++ T + + Y C +N+
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 423 HGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
G + V RP K N A V SA CE P V W+K + P
Sbjct: 207 VGERESEVAELTVLERPSF-VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK 265
Query: 483 EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRI 542
RY I ++ TL+I + T D GSY+C EN +GK +A L ++ V P++ +
Sbjct: 266 S--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 323
Query: 543 PKLHMLELHCESKCDSHLKHSLKLSWSKDGE-----AFEINGTEDGRIIIDGANLTISNV 597
+ CE+ + + W ++G +++ + + +LTI+NV
Sbjct: 324 ALGRTVTFQCEATGNP----QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
Query: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV-PDPPENLHLSERQNRSV------------ 644
D G Y C S + V DV D P + N++V
Sbjct: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
Query: 645 ------RLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRY 698
+ W S I + E N R+ +L G+ T + + +
Sbjct: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT-GRYTCIASTPSGEATW 497
Query: 699 QFRVIAVNEVG-RSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQN 757
I V E G QP +P+D + P A P V + + W+P ++
Sbjct: 498 S-AYIEVQEFGVPVQPPRPTDPNLIPSA-----PSKPEVTDVSRNTVTLSWQP--NLNSG 549
Query: 758 GPGLEYRVTWKPQGAPVEWE--EETVTNHTLRVMTPAVYAPYDVKVQAINQLG-SGPDPQ 814
Y + + W+ E V T + A Y V+A N G S P
Sbjct: 550 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609
Query: 815 SVTLYSGEDYPDTAPV---------------IHGVDVINSTLVKVTWSTVPKDRVHGRLK 859
S + + + P + V +H V++S+ ++V W+ D+ ++
Sbjct: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 666
Query: 860 GYQINWWKTKSLLDGRTHPKEVNILRF---SGQRNSGMVPSLDAFSEFHLTVLAYNSKGA 916
GY+I + + G H E + L F + +NS ++P L + + + ++
Sbjct: 667 GYKILYRPS-----GANH-GESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 720
Query: 917 GPESEPYIFQTPEGVPEQPTFLKVIKVDKDTAT---LSWGLPKKLNGNLTGYLLQYQI 971
G +SE +T E P P + + T +SW P + N G + +Y++
Sbjct: 721 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN--GMVQEYKV 776
Score = 84.3 bits (207), Expect = 6e-16
Identities = 162/759 (21%), Positives = 261/759 (34%), Gaps = 116/759 (15%)
Query: 39 KQSKVQVAFPFDEYFQIECEA-KGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNE 97
+Q+ V E +EC+ +G+PEPT SW KDG+P D RI +
Sbjct: 134 RQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK 193
Query: 98 GHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPK 157
GKY C +N +G SE E V P F K + L V D C +
Sbjct: 194 SDA----GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN-LAVTVDDSAEFKCE-AR 247
Query: 158 GLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQK 217
G P + W + E R + L V D Y C A
Sbjct: 248 GDPVPTVRWRKDDGE--LPKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAE---------- 294
Query: 218 MPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLE 277
N + A S++ T Q P ++ P + + G + +
Sbjct: 295 -------NMVGKAEASATLT---------VQEPPHFVVKPRDQ------VVALGRTVTFQ 332
Query: 278 CFAEGLPTPQVDWNKIGGD------LPKGRETKENYGKT--LKIENVSYQDKGNYRCTAS 329
C A G P P + W + G P ++ + +T L I NV D G Y C
Sbjct: 333 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTL 392
Query: 330 NFLGTATHDFH-----VIVEEPPRWTKK-PQSAVYSTGSNGILLCEAEGEPQPTIKWRVN 383
N G+ + VI + PP ++ P + + +L C A G P PTI WR +
Sbjct: 393 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
Query: 384 GSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDV----VDVRP 439
G V + + + T Y C AS G +A I+V V V+P
Sbjct: 453 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 512
Query: 440 -------LIQTKDGENYATVVGYSAFL-----HCEFFASPEAVV----------SWQKVE 477
LI + + T V + + A+P + + SWQ V
Sbjct: 513 PRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVA 572
Query: 478 E--------VKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI-R 528
E +K L+ +++ ++ S ++ + + + + R
Sbjct: 573 ENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQR 632
Query: 529 NATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGE--------AFEINGT 580
+ NP + +E+H S K+ + G FE+
Sbjct: 633 ELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTP 692
Query: 581 EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPD-PPENLHLSER 639
++I V E + + DS + T+ + P PP+ + +S+
Sbjct: 693 AKNSVVIPDLR---KGVNYEIKARPFFNEFQGADSEIKFAK-TLEEAPSAPPQGVTVSKN 748
Query: 640 QNR--SVRLTWEAGADHNSN--ISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILP-LAP 694
++ ++W+ + N + EY V GN+ R+ V G +V++P L P
Sbjct: 749 DGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDGSTFSVVIPFLVP 805
Query: 695 FVRYQFRVIAVNEVGRSQPSQPS----DHHETPPAAPDR 729
+RY V A G S+P D H P + D+
Sbjct: 806 GIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQ 844
Score = 68.6 bits (166), Expect = 4e-11
Identities = 101/451 (22%), Positives = 164/451 (36%), Gaps = 66/451 (14%)
Query: 30 SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNS 89
+V + P+ +K+ +A D+ + +CEA+G+P PT W KD + + I +
Sbjct: 218 TVLERPSFVKRPS-NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI---RDD 273
Query: 90 GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPI 149
T +I + G Y C A N +G A V P F + D + V G +
Sbjct: 274 HTLKIRKV--TAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQV-VALGRTV 329
Query: 150 VLPCNPPKGLPPLHIYWMNIELEHI-------EQDERVYMSQKGDLYFANVEEKDSRNDY 202
C G P I+W +++ + R +SQ GDL NV+ D Y
Sbjct: 330 TFQCE-ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV--GY 386
Query: 203 CCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGS 262
+I+ K +++T + I R P P G
Sbjct: 387 YICQTLNVAGSIITKAYLEVT--------------------DVIADRPP----PVIRQGP 422
Query: 263 ESSITILKGEILLLECFAEGLPTPQVDWNKIGGDL-PKGRETKENYGKTLKIENVSYQDK 321
+ + G +L C A G P P + W K G + + K+ L+I D
Sbjct: 423 VNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 481
Query: 322 GNYRCTASNFLGTATHDFHVIVEE------PPRWT---------KKPQSAVYSTGSNGIL 366
G Y C AS G AT ++ V+E PPR T KP+ V N +
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE--VTDVSRNTVT 539
Query: 367 L-----CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASN 421
L + P I + + + + V + L+PN ++ A+N
Sbjct: 540 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 599
Query: 422 VHGTILANANIDVVDVRPLIQTKDGENYATV 452
+G + D V + ++ T G ++ V
Sbjct: 600 AYGISDPSQISDPVKTQDVLPTSQGVDHKQV 630
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,014,218
Number of Sequences: 37866
Number of extensions: 2620502
Number of successful extensions: 14272
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 237
Number of HSP's that attempted gapping in prelim test: 5453
Number of HSP's gapped (non-prelim): 4301
length of query: 1224
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1110
effective length of database: 13,930,794
effective search space: 15463181340
effective search space used: 15463181340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.