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Search of human proteins with 27886593
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo
sapiens]
(1074 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 2172 0.0
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 2127 0.0
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 824 0.0
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 824 0.0
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 824 0.0
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 814 0.0
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 236 9e-62
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 232 2e-60
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 226 9e-59
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 225 2e-58
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 225 2e-58
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 223 1e-57
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 223 1e-57
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 222 1e-57
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 222 1e-57
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 222 1e-57
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 222 1e-57
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 222 2e-57
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 220 5e-57
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 220 5e-57
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 220 6e-57
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 219 1e-56
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 218 2e-56
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 217 4e-56
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 217 4e-56
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 217 4e-56
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 217 4e-56
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 217 5e-56
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 216 9e-56
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 216 9e-56
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 2172 bits (5628), Expect = 0.0
Identities = 1074/1074 (100%), Positives = 1074/1074 (100%)
Query: 1 MISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLK 60
MISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLK
Sbjct: 1 MISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLK 60
Query: 61 VFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWL 120
VFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWL
Sbjct: 61 VFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWL 120
Query: 121 HVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLE 180
HVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLE
Sbjct: 121 HVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLE 180
Query: 181 IADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK 240
IADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK
Sbjct: 181 IADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK 240
Query: 241 TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEE 300
TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEE
Sbjct: 241 TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEE 300
Query: 301 GISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAE 360
GISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAE
Sbjct: 301 GISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAE 360
Query: 361 NMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYA 420
NMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYA
Sbjct: 361 NMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYA 420
Query: 421 EIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480
EIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN
Sbjct: 421 EIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480
Query: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSL 540
CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSL
Sbjct: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSL 540
Query: 541 DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYK 600
DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYK
Sbjct: 541 DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYK 600
Query: 601 ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG 660
ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG
Sbjct: 601 ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG 660
Query: 661 ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQ 720
ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQ
Sbjct: 661 ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQ 720
Query: 721 ATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAG 780
ATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAG
Sbjct: 721 ATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAG 780
Query: 781 SIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQE 840
SIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQE
Sbjct: 781 SIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQE 840
Query: 841 MEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPR 900
MEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPR
Sbjct: 841 MEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPR 900
Query: 901 PGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEM 960
PGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEM
Sbjct: 901 PGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEM 960
Query: 961 SSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELI 1020
SSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELI
Sbjct: 961 SSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELI 1020
Query: 1021 NKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH 1074
NKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
Sbjct: 1021 NKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH 1074
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 2127 bits (5511), Expect = 0.0
Identities = 1052/1052 (100%), Positives = 1052/1052 (100%)
Query: 23 MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD 82
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
Sbjct: 1 MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD 60
Query: 83 ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW 142
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
Sbjct: 61 ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW 120
Query: 143 KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY 202
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
Sbjct: 121 KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY 180
Query: 203 WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI 262
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
Sbjct: 181 WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI 240
Query: 263 LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ 322
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ
Sbjct: 241 LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ 300
Query: 323 TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII 382
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
Sbjct: 301 TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII 360
Query: 383 RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE 442
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
Sbjct: 361 RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE 420
Query: 443 RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 502
RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
Sbjct: 421 RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 480
Query: 503 PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 562
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
Sbjct: 481 PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 540
Query: 563 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 622
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
Sbjct: 541 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 600
Query: 623 SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA 682
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
Sbjct: 601 SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA 660
Query: 683 YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY 742
YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
Sbjct: 661 YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY 720
Query: 743 PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE 802
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE
Sbjct: 721 PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE 780
Query: 803 IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS 862
IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
Sbjct: 781 IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS 840
Query: 863 RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE 922
RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE
Sbjct: 841 RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE 900
Query: 923 GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA 982
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
Sbjct: 901 GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA 960
Query: 983 LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM 1042
LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM
Sbjct: 961 LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM 1020
Query: 1043 LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH 1074
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
Sbjct: 1021 LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH 1052
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 824 bits (2128), Expect = 0.0
Identities = 473/1022 (46%), Positives = 637/1022 (62%), Gaps = 74/1022 (7%)
Query: 57 RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 111
R+LKV Y SNS P +++ T++R II I+ S ++ + CYG RL H
Sbjct: 39 RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
Query: 112 LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 171
++S+E+HWLH M V V++KYE H EW+Y+L+IRYLP+ F+ ED+ TL +FYQ
Sbjct: 97 MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
Query: 172 QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 231
Q+++DYM A +V + +AL+LGCLE+RR + +M NAL+KKSN+E+LEK+VGL FFPK
Sbjct: 157 QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
Query: 232 SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 291
+ +++K K RK+IQQTF+Q+A+L EE ++KFF L+ D+E ++C L W I+
Sbjct: 217 QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
Query: 292 VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 351
V+L IGP+ GI LT + PT LA+F Q+++I+ E+ + +LQL I GAP+ L++
Sbjct: 277 VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
Query: 352 TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 409
SL AENMADLIDGYCRL S II P+K+GE+ +LP IP L ++ +
Sbjct: 334 KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
Query: 410 AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 469
+ S+ E+D YAEI DE T P Y I RE + L R +GEG FG+V++G+Y + +
Sbjct: 394 SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
Query: 470 ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 528
+ VA+KTCK +CT D+ +EKF+ EA+ M+ DHPHIVKLIG+I E P WIIMEL GE
Sbjct: 451 KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
Query: 529 LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 588
L +L+ K SL + +L+LY+ Q+ A+AYLES VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 510 LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
Query: 589 LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 648
LSRY+ED YYKAS +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL G +PF +
Sbjct: 570 LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
Query: 649 KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 706
+N DVIG +E G+RLP P CPP LY+LMT+CW YDPS RPRFTEL LS + + EK
Sbjct: 630 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
Query: 707 AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 766
A ++ER +R + + E PPKPSRP Y P + P Q +QV
Sbjct: 690 AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQV 739
Query: 767 SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVL- 825
+ T + YP + L HR ED R Q L
Sbjct: 740 PEGLCASSPTLTSPMEYPSPVNSLHTPPL--HRHNVFKRHSMREEDFIQPSSREEAQQLW 797
Query: 826 --PTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIY 883
M + L +QQ++M ED +WL +EE+ L P V ++ S P+ +
Sbjct: 798 EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE--- 844
Query: 884 QPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSN 943
+ VG + PP+KPPR GA S PTANLDR++
Sbjct: 845 KEVGYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTD 877
Query: 944 DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHR 1003
D VY NV LV+AV+E+ +++ PPE YV +VK VGL LR L+ +VD+ +P LP+S+
Sbjct: 878 DLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
Query: 1004 EIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA 1063
EIE QKLLN DL ELINKM+LAQQ +TSL +E K+QMLTA+H LAVDAKNLLD +DQA
Sbjct: 938 EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA 997
Query: 1064 RL 1065
++
Sbjct: 998 KV 999
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 824 bits (2128), Expect = 0.0
Identities = 473/1022 (46%), Positives = 637/1022 (62%), Gaps = 74/1022 (7%)
Query: 57 RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 111
R+LKV Y SNS P +++ T++R II I+ S ++ + CYG RL H
Sbjct: 39 RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
Query: 112 LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 171
++S+E+HWLH M V V++KYE H EW+Y+L+IRYLP+ F+ ED+ TL +FYQ
Sbjct: 97 MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
Query: 172 QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 231
Q+++DYM A +V + +AL+LGCLE+RR + +M NAL+KKSN+E+LEK+VGL FFPK
Sbjct: 157 QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
Query: 232 SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 291
+ +++K K RK+IQQTF+Q+A+L EE ++KFF L+ D+E ++C L W I+
Sbjct: 217 QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
Query: 292 VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 351
V+L IGP+ GI LT + PT LA+F Q+++I+ E+ + +LQL I GAP+ L++
Sbjct: 277 VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
Query: 352 TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 409
SL AENMADLIDGYCRL S II P+K+GE+ +LP IP L ++ +
Sbjct: 334 KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
Query: 410 AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 469
+ S+ E+D YAEI DE T P Y I RE + L R +GEG FG+V++G+Y + +
Sbjct: 394 SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
Query: 470 ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 528
+ VA+KTCK +CT D+ +EKF+ EA+ M+ DHPHIVKLIG+I E P WIIMEL GE
Sbjct: 451 KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
Query: 529 LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 588
L +L+ K SL + +L+LY+ Q+ A+AYLES VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 510 LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
Query: 589 LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 648
LSRY+ED YYKAS +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL G +PF +
Sbjct: 570 LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
Query: 649 KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 706
+N DVIG +E G+RLP P CPP LY+LMT+CW YDPS RPRFTEL LS + + EK
Sbjct: 630 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
Query: 707 AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 766
A ++ER +R + + E PPKPSRP Y P + P Q +QV
Sbjct: 690 AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQV 739
Query: 767 SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVL- 825
+ T + YP + L HR ED R Q L
Sbjct: 740 PEGLCASSPTLTSPMEYPSPVNSLHTPPL--HRHNVFKRHSMREEDFIQPSSREEAQQLW 797
Query: 826 --PTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIY 883
M + L +QQ++M ED +WL +EE+ L P V ++ S P+ +
Sbjct: 798 EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE--- 844
Query: 884 QPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSN 943
+ VG + PP+KPPR GA S PTANLDR++
Sbjct: 845 KEVGYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTD 877
Query: 944 DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHR 1003
D VY NV LV+AV+E+ +++ PPE YV +VK VGL LR L+ +VD+ +P LP+S+
Sbjct: 878 DLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
Query: 1004 EIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA 1063
EIE QKLLN DL ELINKM+LAQQ +TSL +E K+QMLTA+H LAVDAKNLLD +DQA
Sbjct: 938 EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA 997
Query: 1064 RL 1065
++
Sbjct: 998 KV 999
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 824 bits (2128), Expect = 0.0
Identities = 473/1022 (46%), Positives = 637/1022 (62%), Gaps = 74/1022 (7%)
Query: 57 RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 111
R+LKV Y SNS P +++ T++R II I+ S ++ + CYG RL H
Sbjct: 39 RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
Query: 112 LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 171
++S+E+HWLH M V V++KYE H EW+Y+L+IRYLP+ F+ ED+ TL +FYQ
Sbjct: 97 MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
Query: 172 QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 231
Q+++DYM A +V + +AL+LGCLE+RR + +M NAL+KKSN+E+LEK+VGL FFPK
Sbjct: 157 QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
Query: 232 SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 291
+ +++K K RK+IQQTF+Q+A+L EE ++KFF L+ D+E ++C L W I+
Sbjct: 217 QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
Query: 292 VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 351
V+L IGP+ GI LT + PT LA+F Q+++I+ E+ + +LQL I GAP+ L++
Sbjct: 277 VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
Query: 352 TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 409
SL AENMADLIDGYCRL S II P+K+GE+ +LP IP L ++ +
Sbjct: 334 KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
Query: 410 AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 469
+ S+ E+D YAEI DE T P Y I RE + L R +GEG FG+V++G+Y + +
Sbjct: 394 SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
Query: 470 ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 528
+ VA+KTCK +CT D+ +EKF+ EA+ M+ DHPHIVKLIG+I E P WIIMEL GE
Sbjct: 451 KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
Query: 529 LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 588
L +L+ K SL + +L+LY+ Q+ A+AYLES VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 510 LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
Query: 589 LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 648
LSRY+ED YYKAS +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL G +PF +
Sbjct: 570 LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
Query: 649 KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 706
+N DVIG +E G+RLP P CPP LY+LMT+CW YDPS RPRFTEL LS + + EK
Sbjct: 630 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
Query: 707 AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 766
A ++ER +R + + E PPKPSRP Y P + P Q +QV
Sbjct: 690 AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQV 739
Query: 767 SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVL- 825
+ T + YP + L HR ED R Q L
Sbjct: 740 PEGLCASSPTLTSPMEYPSPVNSLHTPPL--HRHNVFKRHSMREEDFIQPSSREEAQQLW 797
Query: 826 --PTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIY 883
M + L +QQ++M ED +WL +EE+ L P V ++ S P+ +
Sbjct: 798 EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE--- 844
Query: 884 QPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSN 943
+ VG + PP+KPPR GA S PTANLDR++
Sbjct: 845 KEVGYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTD 877
Query: 944 DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHR 1003
D VY NV LV+AV+E+ +++ PPE YV +VK VGL LR L+ +VD+ +P LP+S+
Sbjct: 878 DLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
Query: 1004 EIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA 1063
EIE QKLLN DL ELINKM+LAQQ +TSL +E K+QMLTA+H LAVDAKNLLD +DQA
Sbjct: 938 EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA 997
Query: 1064 RL 1065
++
Sbjct: 998 KV 999
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 814 bits (2102), Expect = 0.0
Identities = 465/1019 (45%), Positives = 631/1019 (61%), Gaps = 110/1019 (10%)
Query: 57 RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 111
R+LKV Y SNS P +++ T++R II I+ S ++ + CYG RL H
Sbjct: 39 RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
Query: 112 LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 171
++S+E+HWLH M V V++KYE H EW+Y+L+IRYLP+ F+ ED+ TL +FYQ
Sbjct: 97 MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
Query: 172 QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 231
Q+++DYM A +V + +AL+LGCLE+RR + +M NAL+KKSN+E+LEK+VGL FFPK
Sbjct: 157 QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
Query: 232 SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 291
+ +++K K RK+IQQTF+Q+A+L EE ++KFF L+ D+E ++C L W I+
Sbjct: 217 QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
Query: 292 VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 351
V+L IGP+ GI LT + PT LA+F Q+++I+ E+ + +LQL I GAP+ L++
Sbjct: 277 VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
Query: 352 TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 409
SL AENMADLIDGYCRL S II P+K+GE+ +LP IP L ++ +
Sbjct: 334 KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
Query: 410 AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 469
+ S+ E+D YAEI DE T P Y I RE + L R +GEG FG+V++G+Y + +
Sbjct: 394 SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
Query: 470 ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 528
+ VA+KTCK +CT D+ +EKF+ EA+ M+ DHPHIVKLIG+I E P WIIMEL GE
Sbjct: 451 KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
Query: 529 LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 588
L +L+ K SL + +L+LY+ Q+ A+AYLES VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 510 LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
Query: 589 LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 648
LSRY+ED YYKAS +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL G +PF +
Sbjct: 570 LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
Query: 649 KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 706
+N DVIG +E G+RLP P CPP LY+LMT+CW YDPS RPRFTEL LS + + EK
Sbjct: 630 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
Query: 707 AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 766
A ++ER +R + + E PPKPSRP Y P + P Q +Q
Sbjct: 690 AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQE 739
Query: 767 SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLP 826
+ I P + R + +W+
Sbjct: 740 EDF------------IQP------------SSREEAQQLWEAEKVK-------------- 761
Query: 827 THLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPV 886
M + L +QQ++M ED +WL +EE+ L P V ++ S P+ + + V
Sbjct: 762 ---MRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE---KEV 805
Query: 887 GKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKV 946
G + PP+KPPR GA S PTANLDR++D V
Sbjct: 806 GYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTDDLV 838
Query: 947 YENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIE 1006
Y NV LV+AV+E+ +++ PPE YV +VK VGL LR L+ +VD+ +P LP+S+ EIE
Sbjct: 839 YLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIE 898
Query: 1007 MAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARL 1065
QKLLN DL ELINKM+LAQQ +TSL +E K+QMLTA+H LAVDAKNLLD +DQA++
Sbjct: 899 GTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKV 957
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 236 bits (602), Expect = 9e-62
Identities = 112/272 (41%), Positives = 172/272 (63%), Gaps = 5/272 (1%)
Query: 431 MPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKF 490
+P + + + E + LG +G+G FG+V++G + VA+KTCK ++ KF
Sbjct: 550 IPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTS----VAVKTCKEDLPQELKIKF 605
Query: 491 LQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYA 549
LQEA ++Q+DHP+IVKLIGV T+ PV+IIMEL + G+ +FL+ +K L L L+ ++
Sbjct: 606 LQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFS 665
Query: 550 YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 609
+ + YLESK +HRD+AARN LV N+ +K+ DFG+SR + Y + ++PIK
Sbjct: 666 LDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIK 725
Query: 610 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 669
W APE++N+ R++S SDVW FG+ +WE GV P+ G+ N ++E G R+ P +C
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHC 785
Query: 670 PPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 701
P + +M KCW Y P RP+F+EL+ +L+ I
Sbjct: 786 PEDISKIMMKCWDYKPENRPKFSELQKELTII 817
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 232 bits (591), Expect = 2e-60
Identities = 126/307 (41%), Positives = 177/307 (57%), Gaps = 7/307 (2%)
Query: 403 KQGMRTHAVSVSETDD-----YAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGD 457
+Q R A V D Y ++ ED E+ + + IGEG+FG+
Sbjct: 578 QQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGE 637
Query: 458 VHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-P 516
V++G P VAIKT K+ + FL+EA M QF HPHI+ L GV+T+ P
Sbjct: 638 VYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKP 697
Query: 517 VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLV 576
+ II E G L +FL+ R+ L L+ +++ + YL + +VHRD+AARN+LV
Sbjct: 698 IMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILV 757
Query: 577 SSNDCVKLGDFGLSRYMED-STYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMW 635
+ N C K+ DFGL+R ++D Y+ GK+PI+W APE+I R FT+ASDVW FG+ MW
Sbjct: 758 NQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMW 817
Query: 636 EILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 695
E+L G KP+ + N +V+ IE+G RLP P +CP LY LM CWAYD +RRP F +L+
Sbjct: 818 EVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQ 877
Query: 696 AQLSTIL 702
A L +L
Sbjct: 878 AHLEQLL 884
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 226 bits (576), Expect = 9e-59
Identities = 120/329 (36%), Positives = 189/329 (57%), Gaps = 25/329 (7%)
Query: 436 DYEIQRERIELGRCIGEGQFGDVHQGIYMS--PENPALAVAIKTCKNCTSDSVREKFLQE 493
++E+ RE+I + R +G+G FG V++G+ + P VAIKT S R +FL E
Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1050
Query: 494 ALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLD---------LA 543
A M++F+ H+V+L+GV+++ P +IMEL T G+L+S+L+ + ++ L+
Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 1110
Query: 544 SLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY-KAS 602
+I A +++ +AYL + +FVHRD+AARN +V+ + VK+GDFG++R + ++ YY K
Sbjct: 1111 KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGG 1170
Query: 603 KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGER 662
KG LP++WM+PES+ FT+ SDVW FGV +WEI +P+QG+ N V+ + G
Sbjct: 1171 KGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL 1230
Query: 663 LPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTIL------------EEEKAQQE 710
L P NCP L+ LM CW Y+P RP F E+ + + + EE K +
Sbjct: 1231 LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEP 1290
Query: 711 ERMRMESRRQATVSWDSGGSDEAPPKPSR 739
E + +E +V D S + P P R
Sbjct: 1291 EELDLEPENMESVPLDPSASSSSLPLPDR 1319
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 225 bits (574), Expect = 2e-58
Identities = 114/270 (42%), Positives = 167/270 (61%), Gaps = 5/270 (1%)
Query: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 497
EI +++ IG G+FG+V +G +P VAIKT K ++ R +FL EA M
Sbjct: 609 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIM 668
Query: 498 RQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 556
QF+HP+I++L GV+T + PV I+ E G L SFL++ + L+ +++ +
Sbjct: 669 GQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 728
Query: 557 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME----DSTYYKASKGKLPIKWMA 612
YL +VHRD+AARN+LV+SN K+ DFGLSR++E D TY + GK+PI+W A
Sbjct: 729 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTA 788
Query: 613 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 672
PE+I FR+FTSASD W +G+ MWE++ G +P+ + N DVI IE RLP PP+CP +
Sbjct: 789 PEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTS 848
Query: 673 LYSLMTKCWAYDPSRRPRFTELKAQLSTIL 702
L+ LM CW D + RPRF ++ + L ++
Sbjct: 849 LHQLMLDCWQKDRNARPRFPQVVSALDKMI 878
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 225 bits (574), Expect = 2e-58
Identities = 116/270 (42%), Positives = 164/270 (60%), Gaps = 5/270 (1%)
Query: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 497
EI +++ IG G+FG+V++G P + VAIKT K S+ R FL EA M
Sbjct: 613 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672
Query: 498 RQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 556
QFDHP+I++L GV+T++ PV II E G L SFL+ + L+ ++ +
Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732
Query: 557 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST----YYKASKGKLPIKWMA 612
YL +VHRD+AARN+LV+SN K+ DFGLSRY++D T Y + GK+P++W A
Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792
Query: 613 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 672
PE+I +R+FTSASDVW +G+ MWE++ G +P+ + N DVI IE RLP P +CP
Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAA 852
Query: 673 LYSLMTKCWAYDPSRRPRFTELKAQLSTIL 702
L+ LM CW D + RPRF E+ L ++
Sbjct: 853 LHQLMLDCWQKDRNSRPRFAEIVNTLDKMI 882
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 223 bits (567), Expect = 1e-57
Identities = 126/313 (40%), Positives = 180/313 (57%), Gaps = 10/313 (3%)
Query: 399 ANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPS--TRDY--EIQRERIELGRCIGEGQ 454
A+SE H S T ID TY P+ R++ EI +++ + IG G+
Sbjct: 573 ADSEYTDKLQHYTSGHMTPGMKIYIDPF-TYEDPNEAVREFAKEIDISCVKIEQVIGAGE 631
Query: 455 FGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE 514
FG+V G P + VAIKT K+ ++ R FL EA M QFDHP+++ L GV+T+
Sbjct: 632 FGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTK 691
Query: 515 N-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARN 573
+ PV II E G L SFL+ + L+ ++ + YL +VHRD+AARN
Sbjct: 692 STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARN 751
Query: 574 VLVSSNDCVKLGDFGLSRYMEDST----YYKASKGKLPIKWMAPESINFRRFTSASDVWM 629
+LV+SN K+ DFGLSR++ED T Y A GK+PI+W APE+I +R+FTSASDVW
Sbjct: 752 ILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 811
Query: 630 FGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRP 689
+G+ MWE++ +G +P+ + N DVI IE RLP P +CP L+ LM CW D + RP
Sbjct: 812 YGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRP 871
Query: 690 RFTELKAQLSTIL 702
+F ++ L ++
Sbjct: 872 KFGQIVNTLDKMI 884
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 223 bits (567), Expect = 1e-57
Identities = 126/313 (40%), Positives = 180/313 (57%), Gaps = 10/313 (3%)
Query: 399 ANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPS--TRDY--EIQRERIELGRCIGEGQ 454
A+SE H S T ID TY P+ R++ EI +++ + IG G+
Sbjct: 574 ADSEYTDKLQHYTSGHMTPGMKIYIDPF-TYEDPNEAVREFAKEIDISCVKIEQVIGAGE 632
Query: 455 FGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE 514
FG+V G P + VAIKT K+ ++ R FL EA M QFDHP+++ L GV+T+
Sbjct: 633 FGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTK 692
Query: 515 N-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARN 573
+ PV II E G L SFL+ + L+ ++ + YL +VHRD+AARN
Sbjct: 693 STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARN 752
Query: 574 VLVSSNDCVKLGDFGLSRYMEDST----YYKASKGKLPIKWMAPESINFRRFTSASDVWM 629
+LV+SN K+ DFGLSR++ED T Y A GK+PI+W APE+I +R+FTSASDVW
Sbjct: 753 ILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 812
Query: 630 FGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRP 689
+G+ MWE++ +G +P+ + N DVI IE RLP P +CP L+ LM CW D + RP
Sbjct: 813 YGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRP 872
Query: 690 RFTELKAQLSTIL 702
+F ++ L ++
Sbjct: 873 KFGQIVNTLDKMI 885
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 222 bits (566), Expect = 1e-57
Identities = 116/268 (43%), Positives = 161/268 (60%), Gaps = 3/268 (1%)
Query: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 497
EI+ I + R IG G+FG+V G P L VAIKT K ++ R FL EA M
Sbjct: 647 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 706
Query: 498 RQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 556
QFDHP+I+ L GV+T++ PV I+ E G L +FL+ + L+ +S +
Sbjct: 707 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 766
Query: 557 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--TYYKASKGKLPIKWMAPE 614
YL +VHRD+AARN+L++SN K+ DFGLSR +ED Y GK+PI+W APE
Sbjct: 767 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 826
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
+I FR+FTSASDVW +G+ MWE++ +G +P+ + N DVI +E G RLP P +CP LY
Sbjct: 827 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 886
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTIL 702
LM CW + + RP+F E+ L ++
Sbjct: 887 QLMLDCWQKERNSRPKFDEIVNMLDKLI 914
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 222 bits (566), Expect = 1e-57
Identities = 116/268 (43%), Positives = 161/268 (60%), Gaps = 3/268 (1%)
Query: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 497
EI+ I + R IG G+FG+V G P L VAIKT K ++ R FL EA M
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 728
Query: 498 RQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 556
QFDHP+I+ L GV+T++ PV I+ E G L +FL+ + L+ +S +
Sbjct: 729 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 788
Query: 557 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--TYYKASKGKLPIKWMAPE 614
YL +VHRD+AARN+L++SN K+ DFGLSR +ED Y GK+PI+W APE
Sbjct: 789 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 848
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
+I FR+FTSASDVW +G+ MWE++ +G +P+ + N DVI +E G RLP P +CP LY
Sbjct: 849 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 908
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTIL 702
LM CW + + RP+F E+ L ++
Sbjct: 909 QLMLDCWQKERNSRPKFDEIVNMLDKLI 936
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 222 bits (566), Expect = 1e-57
Identities = 113/281 (40%), Positives = 169/281 (60%), Gaps = 7/281 (2%)
Query: 432 PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL 491
P+ +E++R I + +G GQ+G+V++G++ + +L VA+KT K T + E+FL
Sbjct: 230 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVW---KKYSLTVAVKTLKEDTMEV--EEFL 284
Query: 492 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYA 549
+EA M++ HP++V+L+GV T E P +II E T G L +L + + ++ L+ A
Sbjct: 285 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 344
Query: 550 YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 609
Q+S+A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIK
Sbjct: 345 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 404
Query: 610 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 669
W APES+ + +F+ SDVW FGV +WEI +G+ P+ G+ + V +E R+ P C
Sbjct: 405 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 464
Query: 670 PPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
P +Y LM CW ++PS RP F E+ T+ +E E
Sbjct: 465 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDE 505
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 222 bits (566), Expect = 1e-57
Identities = 113/281 (40%), Positives = 169/281 (60%), Gaps = 7/281 (2%)
Query: 432 PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL 491
P+ +E++R I + +G GQ+G+V++G++ + +L VA+KT K T + E+FL
Sbjct: 249 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVW---KKYSLTVAVKTLKEDTMEV--EEFL 303
Query: 492 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYA 549
+EA M++ HP++V+L+GV T E P +II E T G L +L + + ++ L+ A
Sbjct: 304 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 363
Query: 550 YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 609
Q+S+A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIK
Sbjct: 364 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 423
Query: 610 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 669
W APES+ + +F+ SDVW FGV +WEI +G+ P+ G+ + V +E R+ P C
Sbjct: 424 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 483
Query: 670 PPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
P +Y LM CW ++PS RP F E+ T+ +E E
Sbjct: 484 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDE 524
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 222 bits (565), Expect = 2e-57
Identities = 112/282 (39%), Positives = 170/282 (60%), Gaps = 7/282 (2%)
Query: 428 TYTMPSTRDYEIQRE----RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTS 483
TY P+ +E +E I + + +G G+FG+V G P ++VAIKT K +
Sbjct: 601 TYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT 660
Query: 484 DSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDL 542
+ R FL EA M QFDHP+I++L GV+T++ PV I+ E G L SFL+ +
Sbjct: 661 EKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTV 720
Query: 543 ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--TYYK 600
L+ +++ + YL +VHRD+AARN+L++SN K+ DFGLSR +ED Y
Sbjct: 721 IQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT 780
Query: 601 ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG 660
GK+PI+W +PE+I +R+FTSASDVW +G+ +WE++ +G +P+ + N DVI ++ G
Sbjct: 781 TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG 840
Query: 661 ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTIL 702
RLP P +CP LY LM CW D + RP+F ++ + L ++
Sbjct: 841 YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLI 882
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 220 bits (561), Expect = 5e-57
Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)
Query: 430 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 487
T P+ I +E ++ + +G G FG V++GI++ E + VAIK T
Sbjct: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
Query: 488 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 547
+F+ EAL M DHPH+V+L+GV + ++ +L G L ++ K ++ L+
Sbjct: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
Query: 548 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 606
+ Q++ + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D Y A GK+
Sbjct: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
Query: 607 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 666
PIKWMA E I++R+FT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP P
Sbjct: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
Query: 667 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 717
P C +Y +M KCW D RP+F EL A+ S + + + Q ++RM++ S
Sbjct: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 220 bits (561), Expect = 5e-57
Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)
Query: 430 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 487
T P+ I +E ++ + +G G FG V++GI++ E + VAIK T
Sbjct: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
Query: 488 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 547
+F+ EAL M DHPH+V+L+GV + ++ +L G L ++ K ++ L+
Sbjct: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
Query: 548 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 606
+ Q++ + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D Y A GK+
Sbjct: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
Query: 607 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 666
PIKWMA E I++R+FT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP P
Sbjct: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
Query: 667 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 717
P C +Y +M KCW D RP+F EL A+ S + + + Q ++RM++ S
Sbjct: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 220 bits (560), Expect = 6e-57
Identities = 133/369 (36%), Positives = 194/369 (52%), Gaps = 15/369 (4%)
Query: 371 RLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYT 430
R++ + S ++ G L I A + ++ + E D+ + TY
Sbjct: 538 RIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYV 597
Query: 431 MPST--------RDY--EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480
P T R++ EI I++ + IG G+FG+V G P + VAIKT K
Sbjct: 598 DPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKA 657
Query: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGELRSFLQVRKYS 539
+D R FL EA M QFDHP+I+ L GV+T+ PV II E G L +FL+
Sbjct: 658 GYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR 717
Query: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--T 597
+ L+ + + + YL +VHRD+AARN+LV+SN K+ DFG+SR +ED
Sbjct: 718 FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEA 777
Query: 598 YYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 657
Y GK+PI+W APE+I +R+FTSASDVW +G+ MWE++ +G +P+ + N DVI I
Sbjct: 778 AYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 837
Query: 658 ENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMES 717
E G RLP P +CP L+ LM CW + S RP+F ++ L ++ + +R ES
Sbjct: 838 EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSL--KRTGTES 895
Query: 718 RRQATVSWD 726
R T D
Sbjct: 896 SRPNTALLD 904
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 219 bits (558), Expect = 1e-56
Identities = 115/285 (40%), Positives = 170/285 (59%), Gaps = 7/285 (2%)
Query: 425 EEDTYTMPSTRDYEIQRER----IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480
+ +TY P+ ++ +E I++ R IG G+FG+V G P +AVAIKT K
Sbjct: 610 DPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV 669
Query: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYS 539
++ R FL EA M QFDHP++V L GV+T PV I++E G L +FL+
Sbjct: 670 GYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQ 729
Query: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--T 597
+ L+ ++ + YL +VHRD+AARN+LV+SN K+ DFGLSR +ED
Sbjct: 730 FTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEA 789
Query: 598 YYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 657
Y + GK+P++W APE+I +R+FTSASDVW +G+ MWE++ +G +P+ + N DVI I
Sbjct: 790 VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 849
Query: 658 ENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTIL 702
E G RLP P +CP L+ LM CW + + RP+F ++ L ++
Sbjct: 850 EEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMI 894
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 218 bits (556), Expect = 2e-56
Identities = 111/270 (41%), Positives = 165/270 (61%), Gaps = 5/270 (1%)
Query: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 497
EI +++ IG G+FG+V +G P + VAIKT K ++ R FL EA M
Sbjct: 627 EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIM 686
Query: 498 RQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 556
QFDHP+I++L GV+T++ PV I+ E L SFL++ + L+ ++ +
Sbjct: 687 GQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 746
Query: 557 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS----TYYKASKGKLPIKWMA 612
YL +VHRD+AARN+LV+SN K+ DFGLSR++ED TY + GK+PI+W A
Sbjct: 747 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 806
Query: 613 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 672
PE+I +R+FTSASDVW +G+ MWE++ +G +P+ + N DVI +E RLP P +CP
Sbjct: 807 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTA 866
Query: 673 LYSLMTKCWAYDPSRRPRFTELKAQLSTIL 702
L+ LM CW D + RP+F+++ L ++
Sbjct: 867 LHQLMLDCWVRDRNLRPKFSQIVNTLDKLI 896
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 217 bits (553), Expect = 4e-56
Identities = 112/276 (40%), Positives = 164/276 (59%), Gaps = 7/276 (2%)
Query: 437 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 496
+E++R I + +G GQ+G+V+ G++ + +L VA+KT K T + E+FL+EA
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVW---KKYSLTVAVKTLKEDTMEV--EEFLKEAAV 320
Query: 497 MRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY-AYQLST 554
M++ HP++V+L+GV T E P +I+ E G L +L+ A ++LY A Q+S+
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380
Query: 555 ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 614
A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIKW APE
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 440
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
S+ + F+ SDVW FGV +WEI +G+ P+ G+ + V +E G R+ P CPP +Y
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
LM CW + P+ RP F E T+ + +E
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEE 536
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 217 bits (553), Expect = 4e-56
Identities = 112/276 (40%), Positives = 164/276 (59%), Gaps = 7/276 (2%)
Query: 437 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 496
+E++R I + +G GQ+G+V+ G++ + +L VA+KT K T + E+FL+EA
Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVW---KKYSLTVAVKTLKEDTMEV--EEFLKEAAV 335
Query: 497 MRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY-AYQLST 554
M++ HP++V+L+GV T E P +I+ E G L +L+ A ++LY A Q+S+
Sbjct: 336 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 395
Query: 555 ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 614
A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIKW APE
Sbjct: 396 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 455
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
S+ + F+ SDVW FGV +WEI +G+ P+ G+ + V +E G R+ P CPP +Y
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
LM CW + P+ RP F E T+ + +E
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEE 551
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 217 bits (553), Expect = 4e-56
Identities = 112/276 (40%), Positives = 164/276 (59%), Gaps = 7/276 (2%)
Query: 437 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 496
+E++R I + +G GQ+G+V+ G++ + +L VA+KT K T + E+FL+EA
Sbjct: 266 WEMERTDITMKHKLGGGQYGEVYVGVW---KKYSLTVAVKTLKEDTMEV--EEFLKEAAV 320
Query: 497 MRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY-AYQLST 554
M++ HP++V+L+GV T E P +I+ E G L +L+ A ++LY A Q+S+
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380
Query: 555 ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 614
A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIKW APE
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 440
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
S+ + F+ SDVW FGV +WEI +G+ P+ G+ + V +E G R+ P CPP +Y
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
LM CW + P+ RP F E T+ + +E
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEE 536
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 217 bits (553), Expect = 4e-56
Identities = 112/276 (40%), Positives = 164/276 (59%), Gaps = 7/276 (2%)
Query: 437 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 496
+E++R I + +G GQ+G+V+ G++ + +L VA+KT K T + E+FL+EA
Sbjct: 245 WEMERTDITMKHKLGGGQYGEVYVGVW---KKYSLTVAVKTLKEDTMEV--EEFLKEAAV 299
Query: 497 MRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY-AYQLST 554
M++ HP++V+L+GV T E P +I+ E G L +L+ A ++LY A Q+S+
Sbjct: 300 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 359
Query: 555 ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 614
A+ YLE K F+HRD+AARN LV N VK+ DFGLSR M TY + K PIKW APE
Sbjct: 360 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 419
Query: 615 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 674
S+ + F+ SDVW FGV +WEI +G+ P+ G+ + V +E G R+ P CPP +Y
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479
Query: 675 SLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQE 710
LM CW + P+ RP F E T+ + +E
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEE 515
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 217 bits (552), Expect = 5e-56
Identities = 119/296 (40%), Positives = 166/296 (56%), Gaps = 3/296 (1%)
Query: 415 ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVA 474
E YAE E+ + EI+ RI + + IG G G+V G P + VA
Sbjct: 606 EPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVA 665
Query: 475 IKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPV-WIIMELCTLGELRSFL 533
IK K ++ R FL EA M QFDHP+I++L GV+T + I+ E G L +FL
Sbjct: 666 IKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFL 725
Query: 534 QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 593
+ + L+ + + YL +VHRD+AARNVLV SN K+ DFGLSR +
Sbjct: 726 RTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVL 785
Query: 594 EDS--TYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN 651
ED Y + GK+PI+W APE+I FR F+SASDVW FGV MWE+L +G +P+ + N
Sbjct: 786 EDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNR 845
Query: 652 DVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKA 707
DVI +E G RLP P CP L+ LM CW D ++RPRF+++ + L ++ ++
Sbjct: 846 DVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPES 901
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 216 bits (550), Expect = 9e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 450 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 509
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 37 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 95
Query: 510 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 569
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 96 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 155
Query: 570 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 627
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 156 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 215
Query: 628 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 687
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 216 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 275
Query: 688 RPRFTELKAQL 698
RP F ++ ++
Sbjct: 276 RPDFLTVEQRM 286
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 216 bits (550), Expect = 9e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 450 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 509
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 344 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402
Query: 510 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 569
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462
Query: 570 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 627
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522
Query: 628 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 687
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582
Query: 688 RPRFTELKAQL 698
RP F ++ ++
Sbjct: 583 RPDFLTVEQRM 593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,213,201
Number of Sequences: 37866
Number of extensions: 2240830
Number of successful extensions: 18303
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 633
Number of HSP's successfully gapped in prelim test: 414
Number of HSP's that attempted gapping in prelim test: 12794
Number of HSP's gapped (non-prelim): 4895
length of query: 1074
length of database: 18,247,518
effective HSP length: 113
effective length of query: 961
effective length of database: 13,968,660
effective search space: 13423882260
effective search space used: 13423882260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.