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Search of human proteins with 27437011
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 1018 0.0
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 1018 0.0
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha... 953 0.0
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 595 e-170
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 595 e-170
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 588 e-168
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 588 e-168
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 508 e-144
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 501 e-142
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 501 e-142
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 145 1e-34
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 144 1e-34
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 144 2e-34
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 142 5e-34
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 142 5e-34
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 142 5e-34
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 142 5e-34
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 142 5e-34
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 142 5e-34
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 142 5e-34
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 142 7e-34
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 142 7e-34
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 142 7e-34
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 141 2e-33
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 141 2e-33
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 141 2e-33
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 141 2e-33
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 141 2e-33
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 141 2e-33
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 139 5e-33
>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 1018 bits (2633), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
Query: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
Sbjct: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Query: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
Sbjct: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
Query: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
Sbjct: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
Query: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
LVKEGFGEGGKSPELPGVQEDEAAS
Sbjct: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 1018 bits (2633), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
Query: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
Sbjct: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Query: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
Sbjct: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
Query: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
Sbjct: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
Query: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
LVKEGFGEGGKSPELPGVQEDEAAS
Sbjct: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
isoform b [Homo sapiens]
Length = 520
Score = 953 bits (2464), Expect = 0.0
Identities = 482/520 (92%), Positives = 482/520 (92%), Gaps = 38/520 (7%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL------------ 228
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240
Query: 229 --------------------------VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 262
VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG
Sbjct: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300
Query: 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI
Sbjct: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360
Query: 323 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 382
SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL
Sbjct: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420
Query: 383 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 442
KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP
Sbjct: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480
Query: 443 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 482
SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV
Sbjct: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520
>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 595 bits (1534), Expect = e-170
Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
S+SAPGNLL K+G + + + P V E+E
Sbjct: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538
>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 595 bits (1534), Expect = e-170
Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
S+SAPGNLL K+G + + + P V E+E
Sbjct: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538
>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 1 [Homo sapiens]
Length = 588
Score = 588 bits (1515), Expect = e-168
Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
Query: 473 SMSAPGNLLVKE 484
S+SAPGNLL K+
Sbjct: 509 SLSAPGNLLTKK 520
>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 5 [Homo sapiens]
Length = 533
Score = 588 bits (1515), Expect = e-168
Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
Query: 473 SMSAPGNLLVKE 484
S+SAPGNLL K+
Sbjct: 509 SLSAPGNLLTKK 520
>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 4 [Homo sapiens]
Length = 498
Score = 508 bits (1309), Expect = e-144
Identities = 263/450 (58%), Positives = 332/450 (73%), Gaps = 55/450 (12%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
ILVK+M+RKRSFGNPFE +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
S+SAPGNLL K+G + + + P V E+E
Sbjct: 466 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 495
>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 3 [Homo sapiens]
Length = 545
Score = 501 bits (1290), Expect = e-142
Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
ILVK+M+RKRSFGNPFE +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
Query: 473 SMSAPGNLLVKE 484
S+SAPGNLL K+
Sbjct: 466 SLSAPGNLLTKK 477
>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 6 [Homo sapiens]
Length = 490
Score = 501 bits (1290), Expect = e-142
Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
ILVK+M+RKRSFGNPFE +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
Query: 473 SMSAPGNLLVKE 484
S+SAPGNLL K+
Sbjct: 466 SLSAPGNLLTKK 477
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 145 bits (365), Expect = 1e-34
Identities = 89/295 (30%), Positives = 156/295 (52%), Gaps = 32/295 (10%)
Query: 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPA 187
Y+L+ +GKG G+V+L + + A+K+++++KL +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV------------------- 74
Query: 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKP- 246
L +V +EIAILK ++H +V+KL +V ++ + LYLV + + G + + K
Sbjct: 75 -----LMKVEREIAILKLIEHPHVLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGR 127
Query: 247 FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ 306
+ ++AR + R ++ L++ H I HRD+KP NLLL + +++IADFG+++ + D+
Sbjct: 128 LTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS-LQVGDSL 186
Query: 307 LSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIK 366
L ++ G+P + PE I G+ + G+ D+W+ GV L+ + G PF DD + L K+K
Sbjct: 187 LETSCGSPHYACPEVI--KGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVK 244
Query: 367 NEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEE 421
VF I + + L+ M++ PE R+ + I+ HPW EP P E
Sbjct: 245 RG--VFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLE 297
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 144 bits (364), Expect = 1e-34
Identities = 87/288 (30%), Positives = 150/288 (52%), Gaps = 32/288 (11%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y ++ +GKG + VV+L + A+K++ K +L
Sbjct: 15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
+ LE++Y+E+ I+K LDH +++KL +V++ + LYLV + + G + +
Sbjct: 57 ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108
Query: 243 CDKP-FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
+ +E +AR ++ ++Y H +KIVHRD+K NLLL ++ ++KIADFG N F+
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
+ L++ G+P + APE GQ + G LD+W+ GV LY V G PF + L
Sbjct: 169 SGEL-LATWCGSPPYAAPEVF--EGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225
Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++ P +SE+ + LI +ML +P R+ + IK H W+
Sbjct: 226 RQRVLEGRFRIPY--FMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM 271
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 144 bits (362), Expect = 2e-34
Identities = 111/356 (31%), Positives = 170/356 (47%), Gaps = 49/356 (13%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
+ +SE A + ++ + ++H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPL-- 417
+++IK F PE ++ E K+LI +ML NP RI HPWV +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMM 282
Query: 418 -PSEEEHCSVVEVTEEEVKNSVRLIPSWTTVIL------VKSMLRKRSFGNPFEPQ 466
E C ++K ++ TT+++ KS+L K+S G EPQ
Sbjct: 283 HRQETVECLRKFNARRKLKGAI-----LTTMLVSRNFSAAKSLLNKKSDGGVKEPQ 333
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 142 bits (359), Expect = 5e-34
Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
+ +SE A ++ ++ + + H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK FP E ++ E KDLI KML NP RI + HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 142 bits (359), Expect = 5e-34
Identities = 103/322 (31%), Positives = 160/322 (49%), Gaps = 36/322 (11%)
Query: 98 HISP-RAWRRPTIESHHVAISDAED-CVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYA 155
HI P ++ R I +I+ A D + Y+LQ IGKG + V+LA + R A
Sbjct: 28 HIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVA 87
Query: 156 MKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLI 215
+K++ K +L P L+++++E+ I+K L+H N+VKL
Sbjct: 88 VKIIDKTQL--------------------NPTS----LQKLFREVRIMKILNHPNIVKLF 123
Query: 216 EVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHR 274
EV++ E LYLV + G V + + E++AR R ++ ++Y H + IVHR
Sbjct: 124 EVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181
Query: 275 DIKPSNLLLGDDGHVKIADFGVSNQFE-GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKA 333
D+K NLLL D ++KIADFG SN+F GN +L + G+P + APE G+ + G
Sbjct: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGN--KLDTFCGSPPYAAPELF--QGKKYDGPE 237
Query: 334 LDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKN 393
+DVW+ GV LY V G PF + L ++ P +S + ++L+ K+L N
Sbjct: 238 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF--YMSTDCENLLKKLLVLN 295
Query: 394 PETRIGVPDIKLHPWVTKNGEE 415
P R + I W+ EE
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEE 317
>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
Length = 433
Score = 142 bits (358), Expect = 7e-34
Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%)
Query: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184
+ +Y + +G+G+YG V+ + A+K+L KKKL R P G
Sbjct: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93
Query: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242
V +EI +L++L H NV++L++VL + + +Y+V + G +++
Sbjct: 94 ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
Query: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301
+K F QA Y +I GLEYLH Q IVH+DIKP NLLL G +KI+D GV+
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
Query: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
D ++ G+PAF PE I++ +FSG +D+W+ GVTLY G PF D I
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417
L I P + L DL+ ML+ P R + I+ H W K E P+
Sbjct: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320
Query: 418 P 418
P
Sbjct: 321 P 321
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 142 bits (358), Expect = 7e-34
Identities = 97/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
+Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50
Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDK 245
A+ LER E I + L H N+V+L + + + E + YL+FDL+ G + E + +
Sbjct: 51 ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 246 PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEG 302
+SE A ++ ++ + + H +VHRD+KP NLLL VK+ADFG++ + EG
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 303 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 362
AGTP +++PE + GK +D+WA GV LY + G PF D+ L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 363 RKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 410
++IK FP E ++ E KDLI KML NP RI + HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 142 bits (358), Expect = 7e-34
Identities = 97/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
+Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50
Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDK 245
A+ LER E I + L H N+V+L + + + E + YL+FDL+ G + E + +
Sbjct: 51 ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 246 PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEG 302
+SE A ++ ++ + + H +VHRD+KP NLLL VK+ADFG++ + EG
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 303 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 362
AGTP +++PE + GK +D+WA GV LY + G PF D+ L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 363 RKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 410
++IK FP E ++ E KDLI KML NP RI + HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 141 bits (355), Expect = 2e-33
Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
+ +SE A + ++ + ++H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK F PE ++ E K+LI +ML NP RI HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 141 bits (355), Expect = 2e-33
Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
+ +SE A + ++ + ++H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK F PE ++ E K+LI +ML NP RI HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 141 bits (355), Expect = 2e-33
Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
+ +SE A + ++ + ++H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK F PE ++ E K+LI +ML NP RI HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 141 bits (355), Expect = 2e-33
Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
+ +SE A + ++ + ++H IVHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
+++IK F PE ++ E K+LI +ML NP RI HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 141 bits (355), Expect = 2e-33
Identities = 92/331 (27%), Positives = 164/331 (49%), Gaps = 45/331 (13%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y L +G G +G V++ ++ A+K+L+++K+
Sbjct: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI------------------ 52
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
+ L + ++ +EI LK H +++KL +V+ P + ++V + + G + +
Sbjct: 53 -----RSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYI 105
Query: 243 CDKPFSEE-QARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
C EE +AR + ++ ++Y H +VHRD+KP N+LL + KIADFG+SN
Sbjct: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
+ L ++ G+P + APE I SG+ ++G +D+W+ GV LY + G PF D+ + L
Sbjct: 166 DGEF-LRTSCGSPNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222
Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN------GEE 415
+KI+ PE ++ + L++ ML +P R + DI+ H W ++ E+
Sbjct: 223 FKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280
Query: 416 PL--------PSEEEHCSVVEVTEEEVKNSV 438
P + +E C E TE EV NS+
Sbjct: 281 PSYDANVIDDEAVKEVCEKFECTESEVMNSL 311
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 141 bits (355), Expect = 2e-33
Identities = 109/360 (30%), Positives = 170/360 (47%), Gaps = 40/360 (11%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L +IGKGA+ VVR YA K+++ KKL
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
A+ LER E I + L H N+V+L + + + E YLVFDL+ G + E +
Sbjct: 51 SARDHQKLER---EARICRLLKHSNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFE 301
+ +SE A ++ ++ + + H +VHRD+KP NLLL VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
G+ AGTP +++PE + GK +D+WA GV LY + G PF D+ L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKEAY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPL-- 417
+++IK F PE ++ E K+LI +ML NP RI + HPWV +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMM 282
Query: 418 -PSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSA 476
E C ++K ++ T KS+L K++ G +PQ + S +A
Sbjct: 283 HRQETVECLKKFNARRKLKGAILTTMLATRNFSAKSLLNKKADG--VKPQTNSTKNSAAA 340
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 139 bits (351), Expect = 5e-33
Identities = 86/314 (27%), Positives = 162/314 (51%), Gaps = 31/314 (9%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y L +G G +G V++ +E A+K+L+++K+
Sbjct: 22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKI------------------ 63
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
+ L + ++ +EI LK H +++KL +V+ P++ +++V + + G + +
Sbjct: 64 -----RSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD--IFMVMEYVSGGELFDYI 116
Query: 243 CDKP-FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
C E+++R + ++ G++Y H +VHRD+KP N+LL + KIADFG+SN
Sbjct: 117 CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 176
Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
+ L ++ G+P + APE I SG+ ++G +D+W++GV LY + G PF DD + L
Sbjct: 177 DGEF-LRTSCGSPNYAAPEVI--SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTL 233
Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEE 421
+KI + +F ++ + L+ ML +P R + DI+ H W ++ + L E+
Sbjct: 234 FKKICDG--IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPED 291
Query: 422 EHCSVVEVTEEEVK 435
S + +E +K
Sbjct: 292 PSYSSTMIDDEALK 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,018,681
Number of Sequences: 37866
Number of extensions: 1182294
Number of successful extensions: 5376
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 731
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3167
Number of HSP's gapped (non-prelim): 1153
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.