Search of human proteins with 27262641

Search of human proteins with 27262641

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
         (458 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]       886   0.0  
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]        848   0.0  
gi|39812229 karyopherin alpha 5 [Homo sapiens]                         83   6e-16
gi|224589129 karyopherin 7 [Homo sapiens]                              79   9e-15
gi|222144293 karyopherin alpha 1 [Homo sapiens]                        78   1e-14
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          77   2e-14
gi|6912478 karyopherin alpha 6 [Homo sapiens]                          76   7e-14
gi|34485722 karyopherin alpha 3 [Homo sapiens]                         72   1e-12
gi|4504897 karyopherin alpha 2 [Homo sapiens]                          69   7e-12
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     65   1e-10
gi|31657114 armadillo repeat containing 4 [Homo sapiens]               49   7e-06
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              42   0.001
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...    40   0.003
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...    40   0.003
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...    40   0.003
gi|11968009 SIL1 protein precursor [Homo sapiens]                      40   0.004
gi|83641896 SIL1 protein precursor [Homo sapiens]                      40   0.004
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                 40   0.006
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]     39   0.010
gi|4826730 FK506 binding protein 12-rapamycin associated protein...    38   0.017
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [...    38   0.022
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [...    38   0.022
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [...    38   0.022
gi|25092658 hypothetical protein LOC221927 [Homo sapiens]              38   0.022
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [...    37   0.037
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [...    37   0.037
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]     37   0.037
gi|154090976 sterile alpha and TIR motif containing 1 [Homo sapi...    37   0.049
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is...    36   0.083
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso...    36   0.083

>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
          Length = 458

 Score =  886 bits (2290), Expect = 0.0
 Identities = 458/458 (100%), Positives = 458/458 (100%)

Query: 1   MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
           MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT
Sbjct: 1   MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60

Query: 61  AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
           AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA
Sbjct: 61  AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120

Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
           IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180

Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
           IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240

Query: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
           VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID
Sbjct: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300

Query: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
           CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL
Sbjct: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360

Query: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
           GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF
Sbjct: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420

Query: 421 LYDAPPNILKHVVGQFSKVLFPWIFRYTSAEGGQLSTT 458
           LYDAPPNILKHVVGQFSKVLFPWIFRYTSAEGGQLSTT
Sbjct: 421 LYDAPPNILKHVVGQFSKVLFPWIFRYTSAEGGQLSTT 458


>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
          Length = 509

 Score =  848 bits (2191), Expect = 0.0
 Identities = 440/440 (100%), Positives = 440/440 (100%)

Query: 1   MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
           MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT
Sbjct: 1   MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60

Query: 61  AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
           AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA
Sbjct: 61  AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120

Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
           IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180

Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
           IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240

Query: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
           VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID
Sbjct: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300

Query: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
           CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL
Sbjct: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360

Query: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
           GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF
Sbjct: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420

Query: 421 LYDAPPNILKHVVGQFSKVL 440
           LYDAPPNILKHVVGQFSKVL
Sbjct: 421 LYDAPPNILKHVVGQFSKVL 440


>gi|39812229 karyopherin alpha 5 [Homo sapiens]
          Length = 539

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 66/266 (24%), Positives = 120/266 (45%), Gaps = 6/266 (2%)

Query: 41  GVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYK 100
           G + +   LL      +Q+ A  ALG +A  N +  + V+ C+ILP L+  L   NR   
Sbjct: 170 GAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTT 229

Query: 101 -KAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNA 157
            + A + L  +  GK+ P     +  C  L+ L   L   DP V     WAL Y++    
Sbjct: 230 TRNAVWALSNLCRGKNPPPNFSKVSPC--LNVLSRLLFSSDPDVLADVCWALSYLSDGPN 287

Query: 158 ELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQM 217
           +  QAV+D+G    LV  +   +  +   A  A+ +I        Q +++  A+  L  +
Sbjct: 288 DKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHL 347

Query: 218 ILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIRE 277
           + +P   ++ +    +S ++  +    + V++A IFPV++  L+  +   +K A+  I  
Sbjct: 348 LSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407

Query: 278 IAK-HTPELSQLVVNAGGVAAVIDCI 302
                TPE  + +V  G +  + D +
Sbjct: 408 ATSGGTPEQIRYLVALGCIKPLCDLL 433



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 74/341 (21%), Positives = 144/341 (42%), Gaps = 6/341 (1%)

Query: 72  NDDLAEAVVKCDILPQLVYSLAE-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
           N  + + + K  ++ + V  L   +N   +  AA+ L  +   +    + +++ GA+   
Sbjct: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175

Query: 131 VICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVLCIQEPEIALKRIAAS 189
           +  L      V+E A WAL  IA  NAE    V++   +P LL L      +   R A  
Sbjct: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235

Query: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
           ALS++ +           +  +  L++++ + D  +   +  ALS +S    D  + V++
Sbjct: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVID 295

Query: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
           + +   ++  L   D  V   A   +  I       +Q+++N   +  ++  + S K + 
Sbjct: 296 SGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESI 355

Query: 310 RLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL-GQIGRHTP 368
           R      +  + A +     AVI +   P L   L ++ E   +  AAWA+       TP
Sbjct: 356 RKEACWTVSNITAGNRAQIQAVIDANIFPVLIEIL-QKAEFRTRKEAAWAITNATSGGTP 414

Query: 369 EHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQ 409
           E  R +     +  L  L ++   S+ +QV +   ++NIL+
Sbjct: 415 EQIRYLVALGCIKPLCDL-LTVMDSKIVQV-ALNGLENILR 453



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 26/116 (22%), Positives = 54/116 (46%)

Query: 34  IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
           I+ + ++GV   L  LL+     +   A  A+G +   +D   + ++ C  LP L++ L+
Sbjct: 290 IQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLS 349

Query: 94  EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL 149
                 +K A + +  +   +    QA++D      L+  L+  +   ++ AAWA+
Sbjct: 350 SPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAI 405


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 65/274 (23%), Positives = 124/274 (45%), Gaps = 5/274 (1%)

Query: 121 IVDCGALDTLVICLED-FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           +++ G +  +V  L+    P ++  AAWAL  IA   +E ++AVV+ GA+  L+  +   
Sbjct: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
            +A+   A  AL +IA   PE    V+ + A+ HL  +I +P   +     I   LS + 
Sbjct: 169 NVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLC 227

Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
           ++           +I P +L  L+ +D  V  +A   +  +   + +    VVN G +  
Sbjct: 228 RNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287

Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
           ++  + S + N   P +  +G +   ++     + I  G+  +   L +  +  I+  AA
Sbjct: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQ-MAIDAGMLNVLPQLLQHNKPSIQKEAA 346

Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTE 391
           WAL  +      H + +   + LP L++L  + E
Sbjct: 347 WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGE 380



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 4/253 (1%)

Query: 29  TRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQL 88
           T  Q    ++   +  L+  L    V   +Q A  ALG +A    +  + V+  + +P L
Sbjct: 145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ-AVWALGNIAGDGPEFRDNVITSNAIPHL 203

Query: 89  VYSLAEQN--RFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
           +  ++      F +     +       +P      V    L  L+  L+  D  V   A 
Sbjct: 204 LALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK-QILPALLHLLQHQDSEVLSDAC 262

Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
           WAL Y+   + +    VV+ G +P LV+ +   E+ +   +   + +I   + E  Q  +
Sbjct: 263 WALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAI 322

Query: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
           DAG +  L Q++ +    ++ +   ALS V+       + ++  ++ P ++  LK+ +  
Sbjct: 323 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFK 382

Query: 267 VKKNASTLIREIA 279
           V+K A  ++   A
Sbjct: 383 VQKEAVWMVANFA 395



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 13/307 (4%)

Query: 59  QTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFY---KKAAAFVLRAVGKHSP 115
           Q    A   L+   +   + V++  ++P++V  L  ++  Y   +  AA+ L  +   + 
Sbjct: 89  QATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFL--KSSLYPCLQFEAAWALTNIASGTS 146

Query: 116 QLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVL 174
           +  +A+V+ GA+  L+  L   +  V E A WAL  IA    E    V+ + A+P LL L
Sbjct: 147 EQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLAL 206

Query: 175 CIQEPEIALKRIAASALSDIAKH-SPELAQTVVD--AGAVAHLAQMILNPDAKLKHQILS 231
                 I   R     LS++ ++ +P    T V     A+ HL Q   + D+++      
Sbjct: 207 ISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ---HQDSEVLSDACW 263

Query: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
           ALS ++  S      VV   + P ++  +   +  V   +   +  I   T E +Q+ ++
Sbjct: 264 ALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAID 323

Query: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
           AG +  +   +   K + +      L  VAA   +    ++    +P L V L +  E  
Sbjct: 324 AGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL-VALLKNGEFK 382

Query: 352 IKAAAAW 358
           ++  A W
Sbjct: 383 VQKEAVW 389



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 1/163 (0%)

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLV 289
           +A   +S+      ++V+EA + P ++  LK      ++  A+  +  IA  T E ++ V
Sbjct: 93  TARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAV 152

Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
           V  G +  +I+ + S         +  LG +A         VI S  +P L   +S    
Sbjct: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP 212

Query: 350 DHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTES 392
                   W L  + R+   +    AV   LP LL L    +S
Sbjct: 213 ITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 255


>gi|222144293 karyopherin alpha 1 [Homo sapiens]
          Length = 538

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 61/239 (25%), Positives = 110/239 (46%), Gaps = 5/239 (2%)

Query: 40  AGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF- 98
           AG + +   LL      +Q+ A  ALG +A  +    + V+ C+ILP L+   ++QNR  
Sbjct: 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLT 227

Query: 99  YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
             + A + L  +  GK  P     +  C  L+ L   L   D  V   A WAL Y++   
Sbjct: 228 MTRNAVWALSNLCRGKSPPPEFAKVSPC--LNVLSWLLFVSDTDVLADACWALSYLSDGP 285

Query: 157 AELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQ 216
            +  QAV+DAG    LV  +   +  +   A  A+ +I        Q +++  A+  L  
Sbjct: 286 NDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLH 345

Query: 217 MILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLI 275
           ++ +P   +K +    +S ++  +    + V++A IFP +++ L+  +   +K A+  I
Sbjct: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 404



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 7/198 (3%)

Query: 43  MSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKA 102
           +++L  LL      +   A  AL  L++  +D  +AV+   +  +LV  L   +    K 
Sbjct: 256 LNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDY---KV 312

Query: 103 AAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAEL 159
            +  LRAVG          Q I++C AL +L+  L      +K+ A W +  I   N   
Sbjct: 313 VSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQ 372

Query: 160 SQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQMI 218
            Q V+DA   P L+  +Q  E   ++ AA A+++     S E  + +V+ G +  L  ++
Sbjct: 373 IQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLL 432

Query: 219 LNPDAKLKHQILSALSQV 236
              D+K+    L+ L  +
Sbjct: 433 TVMDSKIVQVALNGLENI 450



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 53/248 (21%), Positives = 101/248 (40%), Gaps = 2/248 (0%)

Query: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
           +AW L  IA  N+  ++ V+ AGAVP+ +  +      ++  A  AL +IA  S      
Sbjct: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206

Query: 205 VVDAGAVAHLAQMILNPDA-KLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK 263
           V+D   +  L Q+    +   +    + ALS + +      E    +    V+   L   
Sbjct: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266

Query: 264 DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAH 323
           D  V  +A   +  ++    +  Q V++AG    +++ +         P +  +G +   
Sbjct: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT- 325

Query: 324 SENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVL 383
            +++   VI++    Q  + L   P++ IK  A W +  I        + V   N  P L
Sbjct: 326 GDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPAL 385

Query: 384 LSLYMSTE 391
           +S+  + E
Sbjct: 386 ISILQTAE 393



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 59/301 (19%), Positives = 119/301 (39%), Gaps = 2/301 (0%)

Query: 12  QYQKARTQFVQMVAELATRPQNIETLQNAGVMS-LLRTLLLDVVPTIQQTAALALGRLAN 70
           + Q + TQ  + +      P   E +   GV++  +  L      T+Q  +A  L  +A+
Sbjct: 97  EQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIAS 156

Query: 71  YNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
            N      V++   +P  +  L+ +    ++ A + L  +   S      ++DC  L  L
Sbjct: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216

Query: 131 VICLEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAAS 189
           +      +   +   A WAL  + R  +   +    +  + +L   +   +  +   A  
Sbjct: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW 276

Query: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
           ALS ++    +  Q V+DAG    L +++++ D K+    L A+  +        ++++ 
Sbjct: 277 ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN 336

Query: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
                 +L  L    E +KK A   I  I        Q V++A    A+I  + + +  T
Sbjct: 337 CSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRT 396

Query: 310 R 310
           R
Sbjct: 397 R 397



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 34/164 (20%), Positives = 74/164 (45%), Gaps = 1/164 (0%)

Query: 34  IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
           I+ + +AGV   L  LL+     +   A  A+G +   +D   + ++ C  L  L++ L+
Sbjct: 289 IQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLS 348

Query: 94  EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-RYI 152
                 KK A + +  +   +    Q ++D      L+  L+  +   ++ AAWA+    
Sbjct: 349 SPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNAT 408

Query: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
           +  +AE  + +V+ G +  L   +   +  + ++A + L +I +
Sbjct: 409 SGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 452


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 5/269 (1%)

Query: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           ++  G L  LV CLE D +P ++  AAWAL  IA   +E +QAVV + AVPL +  +  P
Sbjct: 110 LIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSP 169

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
              +   A  AL +I    P+    V+  G V  L   I +P   +     +   +  + 
Sbjct: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLC 228

Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
           +H      M    EI P +   +   D  +  +    +  +     E  Q+V+++G V  
Sbjct: 229 RHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPH 288

Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
           ++  +   +   +   +  +G +   ++     V+    +      L+  P++ I   A 
Sbjct: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT-HPKEKINKEAV 347

Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSL 386
           W L  I     +  +AV   N +P+++ L
Sbjct: 348 WFLSNITAGNQQQVQAVIDANLVPMIIHL 376



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 46/304 (15%)

Query: 21  VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77
           VQ   +L +  +N  I+ L  +G++ +L   L  D  P++Q  AA AL  +A+   +  +
Sbjct: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151

Query: 78  AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126
           AVV+ + +P  +  L   ++   + A + L  +    PQ    ++  G            
Sbjct: 152 AVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211

Query: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154
                                           L  L + +   D  +     WAL Y+  
Sbjct: 212 IPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD 271

Query: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214
              E  Q V+D+G VP LV  +   E+ ++  A  A+ +I   + E  Q V++  A++H 
Sbjct: 272 AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHF 331

Query: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274
             ++ +P  K+  + +  LS ++  +    + V++A + P+++  L   D   +K A+  
Sbjct: 332 PALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWA 391

Query: 275 IREI 278
           I  +
Sbjct: 392 ISNL 395



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 2/137 (1%)

Query: 255 VVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPG 313
           VV+   K+K DE++ K  +    +I + +       V    + A++    S     +L  
Sbjct: 32  VVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSA 91

Query: 314 IMMLGYVAAHSENLAMAVIISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHAR 372
           +     + +   N  +  +I  G+ P L  CL  +    ++  AAWAL  I   T E  +
Sbjct: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151

Query: 373 AVAVTNTLPVLLSLYMS 389
           AV  +N +P+ L L  S
Sbjct: 152 AVVQSNAVPLFLRLLHS 168


>gi|6912478 karyopherin alpha 6 [Homo sapiens]
          Length = 536

 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 6/275 (2%)

Query: 32  QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
           Q  + +  AG + +   LL      +Q+ A  ALG +A  +    + V+ C IL  L+  
Sbjct: 158 QQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTL 217

Query: 92  LAEQNRF-YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWA 148
           L +  R    + A + L  +  GK+ P     +  C  L  L   L   D  +   A WA
Sbjct: 218 LTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPC--LPVLSRLLFSSDSDLLADACWA 275

Query: 149 LRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDA 208
           L Y++    E  QAV+D+G    LV  +   +  +   A  A+ +I        Q +++ 
Sbjct: 276 LSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNC 335

Query: 209 GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
            A+  L  ++ +P   ++ +    +S ++  +    + V++A IFPV++  L+  +   +
Sbjct: 336 SALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTR 395

Query: 269 KNASTLIREIAK-HTPELSQLVVNAGGVAAVIDCI 302
           K A+  I       TPE  + +V+ G +  + D +
Sbjct: 396 KEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 69/312 (22%), Positives = 138/312 (44%), Gaps = 11/312 (3%)

Query: 103 AAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQA 162
           AA+ L  +   + Q  + +++ GA+   +  L      V+E A WAL  IA  ++     
Sbjct: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204

Query: 163 VVDAGAV-PLLVLCIQEPEIALKRIAASALSDIAKHS---PELAQTVVDAGAVAHLAQMI 218
           V++   + PLL L  +   + + R A  ALS++ +     PE A+    +  +  L++++
Sbjct: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV---SPCLPVLSRLL 261

Query: 219 LNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREI 278
            + D+ L      ALS +S    +  + V+++ +   ++  L   D  V   A   +  I
Sbjct: 262 FSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNI 321

Query: 279 AKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVP 338
                  +Q+++N   +  ++  + S K + R      +  + A +     AVI +   P
Sbjct: 322 VTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFP 381

Query: 339 QLSVCLSEEPEDHIKAAAAWAL-GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQ 397
            L + + ++ E   +  AAWA+       TPE  R +     +  L  L ++   S+ +Q
Sbjct: 382 VL-IEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL-LTVMDSKIVQ 439

Query: 398 VKSKKAIKNILQ 409
           V +   ++NIL+
Sbjct: 440 V-ALNGLENILR 450



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 53/256 (20%), Positives = 104/256 (40%), Gaps = 1/256 (0%)

Query: 56  TIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSP 115
           T+Q  AA AL  +A+      + V++   +P  +  L       ++ A + L  +   S 
Sbjct: 140 TLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSS 199

Query: 116 QLAQAIVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL 174
                +++C  L+ L+  L +     +   A WAL  + R      +    +  +P+L  
Sbjct: 200 VCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSR 259

Query: 175 CIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALS 234
            +   +  L   A  ALS ++    E  Q V+D+G    L +++++ D K+    L A+ 
Sbjct: 260 LLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVG 319

Query: 235 QVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
            +        ++++     P +L  L    E ++K A   I  I        Q V++A  
Sbjct: 320 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANI 379

Query: 295 VAAVIDCIGSCKGNTR 310
              +I+ +   +  TR
Sbjct: 380 FPVLIEILQKAEFRTR 395


>gi|34485722 karyopherin alpha 3 [Homo sapiens]
          Length = 521

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 63/304 (20%), Positives = 124/304 (40%), Gaps = 46/304 (15%)

Query: 21  VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77
           VQ   +L +  +N  I+ L  +G++ +L + L  D  P++Q  AA AL  +A+      +
Sbjct: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQ 151

Query: 78  AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126
           AVV+ + +P  +  L   ++   + A + L  +    PQ    ++  G            
Sbjct: 152 AVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211

Query: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154
                                           L  L + +   D  +     WAL Y+  
Sbjct: 212 IPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTD 271

Query: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214
              E  Q V+D+G VP LV  +   E+ ++  A  A+ +I   + E  Q V++   ++H 
Sbjct: 272 GGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHF 331

Query: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274
             ++ +P  K+  + +  LS ++  +    + V++A + P+++  L   D   +K A+  
Sbjct: 332 PNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWA 391

Query: 275 IREI 278
           I  +
Sbjct: 392 ISNL 395



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 59/267 (22%), Positives = 111/267 (41%), Gaps = 5/267 (1%)

Query: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           ++  G L  LV CLE D +P ++  AAWAL  IA   +  +QAVV + AVPL +  ++ P
Sbjct: 110 LIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSP 169

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
              +   A  AL +I    P+    V+  G V  L   I +P   +     +   +  + 
Sbjct: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLC 228

Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
           ++      M    EI P +   +   D  +  +    +  +     E  Q+V+++G V  
Sbjct: 229 RNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPF 288

Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
           ++  +   +   +   +  +G +   ++     V+    +      LS  P++ I   A 
Sbjct: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLS-HPKEKINKEAV 347

Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLL 384
           W L  I     +  +AV     +P+++
Sbjct: 348 WFLSNITAGNQQQVQAVIDAGLIPMII 374



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 1/59 (1%)

Query: 332 IISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMS 389
           +I  G+ P L  CL  +    ++  AAWAL  I   T    +AV  +N +P+ L L  S
Sbjct: 110 LIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRS 168


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 56/247 (22%), Positives = 100/247 (40%), Gaps = 6/247 (2%)

Query: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
           +AWAL  IA   +E ++AVVD GA+P  +  +  P   +   A  AL +IA         
Sbjct: 140 SAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 199

Query: 205 VVDAGAVAHLAQMILNPDAK-----LKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTC 259
           V+  GAV  L  ++  PD           +   LS + ++      +    +I P ++  
Sbjct: 200 VIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRL 259

Query: 260 LKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
           L   D  V  +    I  +     E   +VV  G V  ++  +G+ +     P +  +G 
Sbjct: 260 LHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN 319

Query: 320 VAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNT 379
           +   ++     V+I  G   +   L   P+ +I+  A W +  I     +  + V     
Sbjct: 320 IVTGTDEQTQ-VVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 378

Query: 380 LPVLLSL 386
           +P L+S+
Sbjct: 379 VPFLVSV 385



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 5/245 (2%)

Query: 32  QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
           +  + + + G +    +LL      I + A  ALG +A       + V+K   +  L+  
Sbjct: 153 EQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL 212

Query: 92  LAEQNRF-----YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
           LA  +       Y +   + L  + ++             L TLV  L   DP V     
Sbjct: 213 LAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTC 272

Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
           WA+ Y+     E    VV  G VP LV  +   E+ +   A  A+ +I   + E  Q V+
Sbjct: 273 WAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVI 332

Query: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
           DAGA+A    ++ NP   ++ +    +S ++    D  + VV   + P +++ L   D  
Sbjct: 333 DAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFK 392

Query: 267 VKKNA 271
            +K A
Sbjct: 393 TQKEA 397



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 58/288 (20%), Positives = 121/288 (42%), Gaps = 7/288 (2%)

Query: 79  VVKCDILPQLVYSLAEQNRF-YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDF 137
           +++  ++P+ V  L   +    +  +A+ L  +   + +  +A+VD GA+   +  L   
Sbjct: 115 IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174

Query: 138 DPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIA-----LKRIAASALS 192
              + E A WAL  IA   +     V+  GAV  L+  +  P+++       R     LS
Sbjct: 175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234

Query: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
           ++ ++             +  L +++ + D ++      A+S ++    +   MVV+  +
Sbjct: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294

Query: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
            P ++  L   +  +   A   I  I   T E +Q+V++AG +A     + + K N +  
Sbjct: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354

Query: 313 GIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
               +  + A  ++    V+    VP L   LS + +   +  A WA+
Sbjct: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLS-KADFKTQKEAVWAV 401



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 61/259 (23%), Positives = 107/259 (41%), Gaps = 13/259 (5%)

Query: 42  VMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKK 101
           ++  L  LL    P +      A+  L +  ++    VVK  ++PQLV  L         
Sbjct: 252 ILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVT 311

Query: 102 AAAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAE 158
            A   LRA+G     + +  Q ++D GAL      L +    +++ A W +  I     +
Sbjct: 312 PA---LRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQD 368

Query: 159 LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQM 217
             Q VV+ G VP LV  + + +   ++ A  A+++     + E    +V  G +  L  +
Sbjct: 369 QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNL 428

Query: 218 ILNPDAKLKHQILSALSQVSKHSVDLAE------MVVEAEIFPVVLTCLKDKDEYVKKNA 271
           +   D K+   IL A+S + + +  L E      M+ E      +      ++E V K +
Sbjct: 429 LTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKAS 488

Query: 272 STLIREIAKHTPELSQLVV 290
            +LI +      E  Q VV
Sbjct: 489 LSLIEKYFSVEEEEDQNVV 507



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 44/182 (24%), Positives = 80/182 (43%), Gaps = 7/182 (3%)

Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
           +V  G +  LV  L   +  +   A  A+  I     E +Q V+DAGA+ +    +  P+
Sbjct: 289 VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPK 348

Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKL-KHQILSALSQVSKH 239
             +++ A   +S+I     +  Q VV+ G V  L  ++   D K  K  + +  +  S  
Sbjct: 349 TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGG 408

Query: 240 SVDLAEMVVEAEIFPVVLTCLKDKDE---YVKKNASTLIREIAK---HTPELSQLVVNAG 293
           +V+    +V   I   ++  L  KD     V  +A + I + A+    T +LS ++   G
Sbjct: 409 TVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECG 468

Query: 294 GV 295
           G+
Sbjct: 469 GL 470



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 36/174 (20%), Positives = 68/174 (39%), Gaps = 1/174 (0%)

Query: 32  QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
           + I  +   GV+  L  LL      I   A  A+G +    D+  + V+    L      
Sbjct: 284 ERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSL 343

Query: 92  LAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-R 150
           L       +K A + +  +        Q +V+ G +  LV  L   D   ++ A WA+  
Sbjct: 344 LTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTN 403

Query: 151 YIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
           Y +    E    +V  G +  L+  +   +  +  +   A+S+I + + +L +T
Sbjct: 404 YTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGET 457


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 54/236 (22%), Positives = 113/236 (47%), Gaps = 6/236 (2%)

Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILS 231
           LV  +Q      + +A  +L  I   + +  + ++DAG +  L  ++ +   KL+ + + 
Sbjct: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693

Query: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
            LS +S H       +VEA   P ++  L   +  V    + ++ +IA+   E   ++  
Sbjct: 694 LLSNISTHK-SAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC--ENKDVIAK 750

Query: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
             G+ ++I+ +     N  +  +  +  +   +EN   AV   KG+P L   LS +  D 
Sbjct: 751 YNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD-SDV 809

Query: 352 IKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNI 407
           +KA ++ A+ ++GR   E   A+A+   +P L++L+   + S  +Q+K   A++++
Sbjct: 810 LKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS--VQMKGAMAVESL 863



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 68/358 (18%), Positives = 148/358 (41%), Gaps = 13/358 (3%)

Query: 15   KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDD 74
            K + + V +++ ++T    +  L  AG +  L  LL+   P +    A+ L  +A   + 
Sbjct: 686  KLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENK 745

Query: 75   LAEAVVKCDILPQLV--YSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVI 132
              + + K + +P L+   +L  +N          +  +G  + Q  +A+ +   L  L+ 
Sbjct: 746  --DVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQ--RAVREHKGLPYLIR 801

Query: 133  CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
             L      +K  ++ A+  + R N E+  A+   GA+P LV   +  +I+++   A A+ 
Sbjct: 802  FLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVE 861

Query: 193  DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
             +A H+  + +  ++     +L +++      +K Q   AL  ++  ++   + + E   
Sbjct: 862  SLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIG 921

Query: 253  FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDC--IGSCKGNTR 310
            +  ++  L      ++      +  ++K +      +    G+A ++    I +    T 
Sbjct: 922  YSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIAEGTL 981

Query: 311  LPGIMMLGYV---AAHSEN--LAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQI 363
            L  I  +G +    AH+ N      V+     P L   L   P  +IK   A++L  I
Sbjct: 982  LSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACI 1039


>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
          Length = 1044

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 53/329 (16%)

Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           AI D G L+ L+  LE  +   K  +   L+ I+ HN ++ Q +VD G +P++V  +  P
Sbjct: 489 AIRDVGGLEVLINLLETDEVKCKIGSLKILKEIS-HNPQIRQNIVDLGGLPIMVNILDSP 547

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKH 239
             +LK +AA  ++++AK      + V   G +  L  ++                     
Sbjct: 548 HKSLKCLAAETIANVAKFK-RARRVVRQHGGITKLVALL--------------------- 585

Query: 240 SVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAK-HTPELSQLVVNAGGVAAV 298
             D A    +    P   +  + +D  V +  +  +   +K HT +  + +  AGG+  +
Sbjct: 586 --DCAHDSTK----PAQSSLYEARDVEVARCGALALWSCSKSHTNK--EAIRKAGGIPLL 637

Query: 299 IDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAW 358
              + +   N  +P +  L    A  EN   A+   + +  L   L+ E E  ++   A 
Sbjct: 638 ARLLKTSHENMLIPVVGTL-QECASEENYRAAIKAERIIENLVKNLNSENE-QLQEHCAM 695

Query: 359 ALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTY----- 413
           A+ Q      E    V +   L  L SL  +T++ E L      A+   + KC+      
Sbjct: 696 AIYQCA-EDKETRDLVRLHGGLKPLASLLNNTDNKERL-----AAVTGAIWKCSISKENV 749

Query: 414 --------LPALEPFLYDAPPNILKHVVG 434
                   +  L   L D P  +L +VVG
Sbjct: 750 TKFREYKAIETLVGLLTDQPEEVLVNVVG 778



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 56/291 (19%), Positives = 117/291 (40%), Gaps = 20/291 (6%)

Query: 87  QLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
           +++ +L E +    K  +  +     H+PQ+ Q IVD G L  +V  L+     +K  AA
Sbjct: 497 EVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAA 556

Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCI---------------QEPEIALKRIAASAL 191
             +  +A+      + V   G +  LV  +               +  ++ + R  A AL
Sbjct: 557 ETIANVAKFK-RARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALAL 615

Query: 192 SDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAE 251
              +K S    + +  AG +  LA+++      +   ++  L + +      A +  E  
Sbjct: 616 WSCSK-SHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAE-R 673

Query: 252 IFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRL 311
           I   ++  L  ++E ++++ +  I + A+   E   LV   GG+  +   + +     RL
Sbjct: 674 IIENLVKNLNSENEQLQEHCAMAIYQCAE-DKETRDLVRLHGGLKPLASLLNNTDNKERL 732

Query: 312 PGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQ 362
             +    +  + S+         K +  L   L+++PE+ +      ALG+
Sbjct: 733 AAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEE-VLVNVVGALGE 782



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 47/216 (21%), Positives = 84/216 (38%), Gaps = 4/216 (1%)

Query: 24   VAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVK-C 82
            V   A  P+++  +     + LL +LL +  P ++ +AA AL        D  E V    
Sbjct: 821  VGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFV 880

Query: 83   DILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVK 142
              L  +V  L   N+    +    +  + K    LA  I D G +  L       +  ++
Sbjct: 881  GGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLA-VITDHGVVPLLSKLANTNNNKLR 939

Query: 143  EAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELA 202
               A A+            A  +  AV  LV  ++  +  + R  A AL  +++ +    
Sbjct: 940  HHLAEAISRCCMWGRN-RVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCI 998

Query: 203  QTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSK 238
             T+ + GAV  L  M+ +PD  L+      +S + +
Sbjct: 999  -TMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRR 1033


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 60/270 (22%), Positives = 115/270 (42%), Gaps = 37/270 (13%)

Query: 21  VQMVAELATRPQNIETL----QNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLA 76
           ++ +A +A   ++++T+    Q  G+  LL       +P IQ+ AA A+ + A Y+ +  
Sbjct: 251 IEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAA-YDPENR 309

Query: 77  EAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLED 136
           +   + ++   LV  L  +N   K AA+  + A+ ++S   ++   +   +  L+  L+ 
Sbjct: 310 KLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSG--SKDFFNNQGIPQLIQLLKS 367

Query: 137 FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
            +  V+EAAA AL  +   N   + A  +A  +  L+  +          AA+ L+++A 
Sbjct: 368 DNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAM 427

Query: 197 HSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPV- 255
             P              L   I N D  + H I+S L   +      A + V A    V 
Sbjct: 428 QEP--------------LRLNIQNHD--IMHAIISPLRSANTVVQSKAALAVTATACDVE 471

Query: 256 -------------VLTCLKDKDEYVKKNAS 272
                        ++  L+ K++ V+K+AS
Sbjct: 472 ARTELRNSGGLEPLVELLRSKNDEVRKHAS 501



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 69/328 (21%), Positives = 135/328 (41%), Gaps = 14/328 (4%)

Query: 37  LQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDI-LPQLVYSLA-- 93
           LQ    +  +  LL    P IQ  A   LG +AN  D  +  +++ +  L  L+  L   
Sbjct: 187 LQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN--DKESRTMLRDNQGLDHLIKILETK 244

Query: 94  EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFD-PGVKEAAAWALRYI 152
           E N  + +A A +   +      +   I   G L  L+   E+   P +++ AA A+   
Sbjct: 245 ELNDLHIEALAVIANCLEDMDTMVQ--IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKA 302

Query: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVA 212
           A ++ E  +   +      LV  +       K  A+ A+S + ++S   ++   +   + 
Sbjct: 303 A-YDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSG--SKDFFNNQGIP 359

Query: 213 HLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNAS 272
            L Q++ + + +++     AL+ ++  +   A    EA+    ++  L  K +    NA+
Sbjct: 360 QLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAA 419

Query: 273 TLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVI 332
           T++  +A   P L   + N   + A+I  + S   NT +     L   A   +  A   +
Sbjct: 420 TVLTNMAMQEP-LRLNIQNHDIMHAIISPLRS--ANTVVQSKAALAVTATACDVEARTEL 476

Query: 333 ISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
            + G  +  V L     D ++  A+WA+
Sbjct: 477 RNSGGLEPLVELLRSKNDEVRKHASWAV 504



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 48/249 (19%), Positives = 107/249 (42%), Gaps = 9/249 (3%)

Query: 163 VVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPD 222
           ++++     +VL +  PE  +   A  A+   A    E   T+++ GAV  L +++ + D
Sbjct: 21  MIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHED 80

Query: 223 AKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNAST--LIREIAK 280
            K+  +  + +  +   + D+ +++ E ++   V+  L  ++E V    ++  L    A+
Sbjct: 81  -KIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139

Query: 281 HTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQL 340
           +T ++   +   GG+  +I  + S   + +   +  +  +    +  A    ++   P L
Sbjct: 140 YTSKVQ--IFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPIL 197

Query: 341 SVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKS 400
            +  SE P   I+  A   LG I     + +R +   N     L   + T+   DL +++
Sbjct: 198 DLLKSEYPV--IQLLALKTLGVIA--NDKESRTMLRDNQGLDHLIKILETKELNDLHIEA 253

Query: 401 KKAIKNILQ 409
              I N L+
Sbjct: 254 LAVIANCLE 262


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)

Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
           A P  V  + EP   LK    + ++     ++A  + PEL + + D        Q+++N 
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170

Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
            A + HQ+  +  + S+H++  +  +V A    +V T     D    +  +  +  ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224

Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
              L   +  +GG+ A++  +GS   +     I  L  +  H E   MAV ++ G+ ++ 
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283

Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
             L++     +  A      QI  +  + ++ + + +  P  L   M T + E L   + 
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341

Query: 402 KAIKNILQKCT 412
           + +K +L  C+
Sbjct: 342 RVLK-VLSVCS 351



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)

Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
           + E    AL  +AR  HN  + + +     +PL V  +  P   ++R+AA  L ++A+  
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624

Query: 199 PELAQTVVDAGAVAHLAQMI 218
            E A+ +   GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)

Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           AIV+ G +  L + L D    + +   W LR ++  +A   Q  ++ G +  LV  +   
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
           +I +   AA  LS++  ++ +    V   G +  L + +L    +  +    + AL  + 
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472

Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
           S+H   ++A+  V      PVV+  L     +    A+  LIR +    A H        
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532

Query: 283 -PELSQLVVNA 292
            P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)

Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
           A P  V  + EP   LK    + ++     ++A  + PEL + + D        Q+++N 
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170

Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
            A + HQ+  +  + S+H++  +  +V A    +V T     D    +  +  +  ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224

Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
              L   +  +GG+ A++  +GS   +     I  L  +  H E   MAV ++ G+ ++ 
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283

Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
             L++     +  A      QI  +  + ++ + + +  P  L   M T + E L   + 
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341

Query: 402 KAIKNILQKCT 412
           + +K +L  C+
Sbjct: 342 RVLK-VLSVCS 351



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)

Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
           + E    AL  +AR  HN  + + +     +PL V  +  P   ++R+AA  L ++A+  
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624

Query: 199 PELAQTVVDAGAVAHLAQMI 218
            E A+ +   GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)

Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           AIV+ G +  L + L D    + +   W LR ++  +A   Q  ++ G +  LV  +   
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
           +I +   AA  LS++  ++ +    V   G +  L + +L    +  +    + AL  + 
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472

Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
           S+H   ++A+  V      PVV+  L     +    A+  LIR +    A H        
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532

Query: 283 -PELSQLVVNA 292
            P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)

Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
           A P  V  + EP   LK    + ++     ++A  + PEL + + D        Q+++N 
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170

Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
            A + HQ+  +  + S+H++  +  +V A    +V T     D    +  +  +  ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224

Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
              L   +  +GG+ A++  +GS   +     I  L  +  H E   MAV ++ G+ ++ 
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283

Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
             L++     +  A      QI  +  + ++ + + +  P  L   M T + E L   + 
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341

Query: 402 KAIKNILQKCT 412
           + +K +L  C+
Sbjct: 342 RVLK-VLSVCS 351



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)

Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
           + E    AL  +AR  HN  + + +     +PL V  +  P   ++R+AA  L ++A+  
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624

Query: 199 PELAQTVVDAGAVAHLAQMI 218
            E A+ +   GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)

Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
           AIV+ G +  L + L D    + +   W LR ++  +A   Q  ++ G +  LV  +   
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412

Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
           +I +   AA  LS++  ++ +    V   G +  L + +L    +  +    + AL  + 
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472

Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
           S+H   ++A+  V      PVV+  L     +    A+  LIR +    A H        
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532

Query: 283 -PELSQLVVNA 292
            P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543


>gi|11968009 SIL1 protein precursor [Homo sapiens]
          Length = 461

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 1/107 (0%)

Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAV-PL 171
           H    AQ ++  G L  ++  L   +P VKE AA+ L      N ++    ++ GA+  L
Sbjct: 214 HQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKL 273

Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMI 218
           LV+   E  +  K+    AL  + +H P   +  +  G +  L  ++
Sbjct: 274 LVILATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLV 320



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 1/106 (0%)

Query: 74  DLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVIC 133
           D A+ ++    L  ++  L       K+ AAFVL A    +P++    ++ GAL  L++ 
Sbjct: 217 DNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVI 276

Query: 134 LEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQE 178
           L    P   K+   +AL  + RH     +  +  G + +L   +QE
Sbjct: 277 LATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLVQE 322



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 37/165 (22%), Positives = 69/165 (41%), Gaps = 4/165 (2%)

Query: 238 KHSVDLAEMVVEAEIFPVVLTCLK---DKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
           K   D   +V+E ++  +V    K         +K A+    E   H  + +Q +++ GG
Sbjct: 168 KKDFDELNVVIETDMQIMVRLINKFNSSSSSLEEKIAALFDLEYYVHQMDNAQDLLSFGG 227

Query: 295 VAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKA 354
           +  VI+ + S +   +     +LG   + +  + +  I    + +L V L+ E     K 
Sbjct: 228 LQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLTAKK 287

Query: 355 AAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVK 399
              +AL  + RH P   R       L VL +L +  + +E L V+
Sbjct: 288 KVLFALCSLLRHFPYAQRQFLKLGGLQVLRTL-VQEKGTEVLAVR 331


>gi|83641896 SIL1 protein precursor [Homo sapiens]
          Length = 461

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 1/107 (0%)

Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAV-PL 171
           H    AQ ++  G L  ++  L   +P VKE AA+ L      N ++    ++ GA+  L
Sbjct: 214 HQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKL 273

Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMI 218
           LV+   E  +  K+    AL  + +H P   +  +  G +  L  ++
Sbjct: 274 LVILATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLV 320



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 1/106 (0%)

Query: 74  DLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVIC 133
           D A+ ++    L  ++  L       K+ AAFVL A    +P++    ++ GAL  L++ 
Sbjct: 217 DNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVI 276

Query: 134 LEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQE 178
           L    P   K+   +AL  + RH     +  +  G + +L   +QE
Sbjct: 277 LATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLVQE 322



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 37/165 (22%), Positives = 69/165 (41%), Gaps = 4/165 (2%)

Query: 238 KHSVDLAEMVVEAEIFPVVLTCLK---DKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
           K   D   +V+E ++  +V    K         +K A+    E   H  + +Q +++ GG
Sbjct: 168 KKDFDELNVVIETDMQIMVRLINKFNSSSSSLEEKIAALFDLEYYVHQMDNAQDLLSFGG 227

Query: 295 VAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKA 354
           +  VI+ + S +   +     +LG   + +  + +  I    + +L V L+ E     K 
Sbjct: 228 LQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLTAKK 287

Query: 355 AAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVK 399
              +AL  + RH P   R       L VL +L +  + +E L V+
Sbjct: 288 KVLFALCSLLRHFPYAQRQFLKLGGLQVLRTL-VQEKGTEVLAVR 331


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 53/224 (23%), Positives = 96/224 (42%), Gaps = 10/224 (4%)

Query: 18   TQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTA-ALALGRLANYNDDLA 76
            T   Q V  ++  P+ I +  +  ++S    L  D++  +  TA  L+   L+   + LA
Sbjct: 1046 TSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLA 1105

Query: 77   EAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVD-CGALDTLVICLE 135
             +      L  L   L       +     +L  + +HS  L  A+    G L  L++ L 
Sbjct: 1106 GSDESYRPLRSL---LGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLG 1162

Query: 136  DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
            D DP V+ +A++A+   A     L  A+  A AVP +   + +P+  ++R  ASAL ++ 
Sbjct: 1163 DKDPVVRCSASFAVGNAAYQAGPLGPAL--AAAVPSMTQLLGDPQAGIRRNVASALGNLG 1220

Query: 196  KHSPELAQTVVDAGAVAHLAQMIL-NPDAKLKHQILSALSQVSK 238
                 L + ++       L +M   +P   +K   L AL  + +
Sbjct: 1221 PEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQ 1262


>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
          Length = 348

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 60/266 (22%), Positives = 101/266 (37%), Gaps = 62/266 (23%)

Query: 15  KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLD--------VVPTIQQTAALALG 66
           + R + +  + +L   P+ I    N G M  L+ LL D            +  TA+ ++G
Sbjct: 41  QTRQKALMALCDLMHDPECIYKAMNIGCMENLKALLKDSNSMVRIKTTEVLHITASHSVG 100

Query: 67  RLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA 126
           R A    D+  A+      P  V     +   YK     V        P+ AQ I+  G 
Sbjct: 101 RYAFLEHDIVLALSFLLNDPSPVC----RGNLYKAYMQLV------QVPRGAQEIISKGL 150

Query: 127 LDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRI 186
           + +LV               W L+ +     E  + ++D      LVLC+QE        
Sbjct: 151 ISSLV---------------WKLQ-VEVEEEEFQEFILDT-----LVLCLQED------- 182

Query: 187 AASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEM 246
                          A   + +  V  L Q +L+ +  ++ +   AL  VS  S +  + 
Sbjct: 183 ---------------ATEALGSNVVLVLKQKLLSANQNIRSKAARALLNVSI-SREGKKQ 226

Query: 247 VVEAEIFPVVLTCLKDKDEYVKKNAS 272
           V   ++ P+++  LKD  E+VK NA+
Sbjct: 227 VCHFDVIPILVHLLKDPVEHVKSNAA 252


>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
           [Homo sapiens]
          Length = 2549

 Score = 38.1 bits (87), Expect = 0.017
 Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 1/105 (0%)

Query: 46  LRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAF 105
           LR LL    P + + A+ A+GRLA   D      V+ ++   L +  A++N   + AA  
Sbjct: 111 LRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVL 170

Query: 106 VLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALR 150
           VLR +    P      V     D + + + D    ++E A  ALR
Sbjct: 171 VLRELAISVPTFFFQQVQ-PFFDNIFVAVWDPKQAIREGAVAALR 214


>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
           [Homo sapiens]
          Length = 607

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 11  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 70  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 128

Query: 291 NAGGVAAVIDCIGS 304
            AGG   VID + S
Sbjct: 129 QAGGAQIVIDHLRS 142



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529

Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
           E A++  ++   L D+     +K N+  LI
Sbjct: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559


>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
           [Homo sapiens]
          Length = 607

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 71  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129

Query: 291 NAGGVAAVIDCIGS 304
            AGG   VID + S
Sbjct: 130 QAGGAQIVIDHLRS 143



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529

Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
           E A++  ++   L D+     +K N+  LI
Sbjct: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559


>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
           [Homo sapiens]
          Length = 608

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 71  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129

Query: 291 NAGGVAAVIDCIGS 304
            AGG   VID + S
Sbjct: 130 QAGGAQIVIDHLRS 143



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 471 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 530

Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
           E A++  ++   L D+     +K N+  LI
Sbjct: 531 ESAKLVQILHRLLADERSAPEIKYNSMVLI 560


>gi|25092658 hypothetical protein LOC221927 [Homo sapiens]
          Length = 821

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 19/48 (39%), Positives = 33/48 (68%), Gaps = 6/48 (12%)

Query: 332 IISKGVPQLSVCLSEEPEDHIKAAAAWALGQI---GRH---TPEHARA 373
           +++  VPQL++ L ++PE +++A+A  A+GQ+   G H   +PEHA A
Sbjct: 541 LLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEA 588



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 6/76 (7%)

Query: 214 LAQMILNPDAKLKHQILSALSQVSKH---SVDLAEMVVEAEIFPVVLTCLKDKDEYVKKN 270
           L + + +P  +++   L  L+Q+S+H     D    ++ +E+  + L  L+D + YV+ +
Sbjct: 505 LQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRAS 564

Query: 271 ASTLIREIAK---HTP 283
           A T + +++    H P
Sbjct: 565 AVTAMGQLSSQGLHAP 580


>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
           [Homo sapiens]
          Length = 558

 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/149 (17%), Positives = 67/149 (44%), Gaps = 2/149 (1%)

Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 11  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   +  L   ++
Sbjct: 70  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLI 128

Query: 291 NAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
           N G +  ++  +G    N  L  + ++ +
Sbjct: 129 NMGVIPTLVKLLGIHCQNAALTEMCLVAF 157



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 421 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 480

Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
           E A++  ++   L D+     +K N+  LI
Sbjct: 481 ESAKLVQILHRLLADERSAPEIKYNSMVLI 510


>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
           [Homo sapiens]
          Length = 559

 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/149 (17%), Positives = 67/149 (44%), Gaps = 2/149 (1%)

Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70

Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   +  L   ++
Sbjct: 71  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLI 129

Query: 291 NAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
           N G +  ++  +G    N  L  + ++ +
Sbjct: 130 NMGVIPTLVKLLGIHCQNAALTEMCLVAF 158



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 422 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 481

Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
           E A++  ++   L D+     +K N+  LI
Sbjct: 482 ESAKLVQILHRLLADERSAPEIKYNSMVLI 511


>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
          Length = 493

 Score = 37.0 bits (84), Expect = 0.037
 Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 4/116 (3%)

Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
           HS Q   A     A   L+  L        E   + L  +   +  + + ++  G VP L
Sbjct: 137 HSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPAL 196

Query: 173 VLCIQEPEIALKRIAASALSDI--AKHSPE-LAQTVVDAGAVAHLAQMILNPDAKL 225
             CIQ P +A+      ALS +  A+ +PE +  +++ +    H+ QM L P  KL
Sbjct: 197 AACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM-LQPGPKL 251


>gi|154090976 sterile alpha and TIR motif containing 1 [Homo
           sapiens]
          Length = 724

 Score = 36.6 bits (83), Expect = 0.049
 Identities = 45/187 (24%), Positives = 78/187 (41%), Gaps = 8/187 (4%)

Query: 39  NAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF 98
           + G+  LLR L    + T  Q A L    L   N D    +    IL     +LA++   
Sbjct: 123 DGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVIL-----NLAKEREP 177

Query: 99  YK--KAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
            +  ++ A +L  + KHS +  Q +V  G LD ++      DP +    A AL   A H 
Sbjct: 178 VELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHG 237

Query: 157 AE-LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLA 215
            + + + +V+  A   L       E  L R+ A     +   + E+ + V  +G +A + 
Sbjct: 238 GQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVE 297

Query: 216 QMILNPD 222
            ++ + D
Sbjct: 298 PLVASLD 304



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 8/197 (4%)

Query: 200 ELAQTVVDA----GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPV 255
           E+AQ + DA    G +  L +++  P+ + + Q    L Q+     +  + V    +  V
Sbjct: 111 EVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILV--AENRDRVARIGL-GV 167

Query: 256 VLTCLKDKDEY-VKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGI 314
           +L   K+++   + ++ + ++  + KH+ E  Q +V AGG+ AV+               
Sbjct: 168 ILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCA 227

Query: 315 MMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAV 374
           + LG  A H        ++ K   +    L+   ED +    A     +     E  R V
Sbjct: 228 LALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREV 287

Query: 375 AVTNTLPVLLSLYMSTE 391
             + TL ++  L  S +
Sbjct: 288 ERSGTLALVEPLVASLD 304


>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
           isoform a [Homo sapiens]
          Length = 951

 Score = 35.8 bits (81), Expect = 0.083
 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%)

Query: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
           P +V C+Q   + LK++    L + AK  P++A   V++             D +  + +
Sbjct: 52  PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101

Query: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
           + AL+  +   + + + + E    P+   CLKD+D YV+K A+     +AK     +Q+V
Sbjct: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156

Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346
            + G + ++ D I           +  L  ++    N  +  +  + + +L   L+E
Sbjct: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 61/310 (19%), Positives = 117/310 (37%), Gaps = 71/310 (22%)

Query: 46  LRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAF 105
           LR  L D  P +++TAA+ + +L + N  + E     D L  L+   A+ N      A  
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLI---ADSNPMVVANAVA 182

Query: 106 VLRAVGKHSP-------------QLAQAIVDCGALDTLVI--CLEDFDP-GVKEAAAWAL 149
            L  + +  P             +L  A+ +C     + I  CL +++P   +EA +   
Sbjct: 183 ALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICE 242

Query: 150 RYIARHNAELSQAVVDAGAV------------------------PLLVLCIQEPEIALKR 185
           R   R +   S  V+ A  V                        PL+ L   EPE+  + 
Sbjct: 243 RVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEV--QY 300

Query: 186 IAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI-LSALSQVSKHSVDLA 244
           +A   ++ I +  PE+ +  +    V +   + +  + KL   I L++ + +++   +L 
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLE-KLDIMIRLASQANIAQVLAELK 359

Query: 245 EMVVEAEI------------------------FPVVLTCLKDKDEYVKKNASTLIREIAK 280
           E   E ++                           +L  ++ K  YV + A  +IR+I +
Sbjct: 360 EYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFR 419

Query: 281 HTPELSQLVV 290
             P   + ++
Sbjct: 420 KYPNKYESII 429


>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
           isoform b [Homo sapiens]
          Length = 937

 Score = 35.8 bits (81), Expect = 0.083
 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%)

Query: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
           P +V C+Q   + LK++    L + AK  P++A   V++             D +  + +
Sbjct: 52  PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101

Query: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
           + AL+  +   + + + + E    P+   CLKD+D YV+K A+     +AK     +Q+V
Sbjct: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156

Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346
            + G + ++ D I           +  L  ++    N  +  +  + + +L   L+E
Sbjct: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 61/310 (19%), Positives = 117/310 (37%), Gaps = 71/310 (22%)

Query: 46  LRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAF 105
           LR  L D  P +++TAA+ + +L + N  + E     D L  L+   A+ N      A  
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLI---ADSNPMVVANAVA 182

Query: 106 VLRAVGKHSP-------------QLAQAIVDCGALDTLVI--CLEDFDP-GVKEAAAWAL 149
            L  + +  P             +L  A+ +C     + I  CL +++P   +EA +   
Sbjct: 183 ALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICE 242

Query: 150 RYIARHNAELSQAVVDAGAV------------------------PLLVLCIQEPEIALKR 185
           R   R +   S  V+ A  V                        PL+ L   EPE+  + 
Sbjct: 243 RVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEV--QY 300

Query: 186 IAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI-LSALSQVSKHSVDLA 244
           +A   ++ I +  PE+ +  +    V +   + +  + KL   I L++ + +++   +L 
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLE-KLDIMIRLASQANIAQVLAELK 359

Query: 245 EMVVEAEI------------------------FPVVLTCLKDKDEYVKKNASTLIREIAK 280
           E   E ++                           +L  ++ K  YV + A  +IR+I +
Sbjct: 360 EYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFR 419

Query: 281 HTPELSQLVV 290
             P   + ++
Sbjct: 420 KYPNKYESII 429


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.132    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,082,157
Number of Sequences: 37866
Number of extensions: 579984
Number of successful extensions: 1717
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 1484
Number of HSP's gapped (non-prelim): 151
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.