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Search of human proteins with 27262634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ... 1532 0.0
gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ... 1456 0.0
gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo ... 610 e-174
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 94 4e-19
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 94 6e-19
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 94 6e-19
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 93 8e-19
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 75 2e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 74 7e-13
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 73 9e-13
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 72 2e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 72 3e-12
gi|16262452 cingulin [Homo sapiens] 70 6e-12
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 68 3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 8e-11
gi|104526627 triadin [Homo sapiens] 67 8e-11
gi|24415404 MDN1, midasin homolog [Homo sapiens] 66 1e-10
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 65 2e-10
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 65 2e-10
gi|210032580 SET domain containing 1B [Homo sapiens] 65 3e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 64 4e-10
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 64 7e-10
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 64 7e-10
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 64 7e-10
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 64 7e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 63 9e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 62 2e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 2e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 2e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 2e-09
>gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
sapiens]
Length = 790
Score = 1532 bits (3966), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIHLDVDSEAKKLLGLGQKHLVMGD 60
MFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIHLDVDSEAKKLLGLGQKHLVMGD
Sbjct: 1 MFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIHLDVDSEAKKLLGLGQKHLVMGD 60
Query: 61 IPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEE 120
IPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEE
Sbjct: 61 IPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEE 120
Query: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM 180
EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM
Sbjct: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM 180
Query: 181 EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPD 240
EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPD
Sbjct: 181 EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPD 240
Query: 241 AEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAE 300
AEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAE
Sbjct: 241 AEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAE 300
Query: 301 SLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVE 360
SLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVE
Sbjct: 301 SLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVE 360
Query: 361 AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKL 420
AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKL
Sbjct: 361 AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKL 420
Query: 421 VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE 480
VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE
Sbjct: 421 VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE 480
Query: 481 GSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQ 540
GSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQ
Sbjct: 481 GSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQ 540
Query: 541 LYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNS 600
LYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNS
Sbjct: 541 LYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNS 600
Query: 601 QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 660
QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE
Sbjct: 601 QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 660
Query: 661 SQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRK 720
SQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRK
Sbjct: 661 SQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRK 720
Query: 721 KRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 780
KRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE
Sbjct: 721 KRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 780
Query: 781 AGATVESTAC 790
AGATVESTAC
Sbjct: 781 AGATVESTAC 790
>gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
sapiens]
Length = 788
Score = 1456 bits (3770), Expect = 0.0
Identities = 752/757 (99%), Positives = 755/757 (99%)
Query: 34 NRIIHLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 93
+++ LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY
Sbjct: 32 DKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 91
Query: 94 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 153
GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM
Sbjct: 92 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 151
Query: 154 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 213
GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE
Sbjct: 152 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 211
Query: 214 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 273
EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE
Sbjct: 212 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 271
Query: 274 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333
EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE
Sbjct: 272 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 331
Query: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393
QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP
Sbjct: 332 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 391
Query: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS
Sbjct: 392 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 451
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513
PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE
Sbjct: 452 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 511
Query: 514 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 573
IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL
Sbjct: 512 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 571
Query: 574 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 633
QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS
Sbjct: 572 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 631
Query: 634 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 693
SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV
Sbjct: 632 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 691
Query: 694 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 753
SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS
Sbjct: 692 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 751
Query: 754 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 790
GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 752 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788
>gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo
sapiens]
Length = 449
Score = 610 bits (1574), Expect = e-174
Identities = 341/468 (72%), Positives = 366/468 (78%), Gaps = 23/468 (4%)
Query: 324 ENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVN 383
E+ A AV +LV + E+ P +T A + +++ SE + G L
Sbjct: 4 ESTATAAVAAELVSAD--KIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHL------- 54
Query: 384 GPSVVGD-QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVD 442
V+GD + L K G E A + +L+ E+ G+ ++
Sbjct: 55 ---VMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALE 111
Query: 443 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 502
+ + ED+ + N+ +ETEGSEEDDKENDKTEEMPNDSVLE
Sbjct: 112 GVHVEEEEGEKTEDESLVENNDNI----------DETEGSEEDDKENDKTEEMPNDSVLE 161
Query: 503 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 562
NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ
Sbjct: 162 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221
Query: 563 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 622
AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV
Sbjct: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281
Query: 623 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 682
LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS
Sbjct: 282 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 341
Query: 683 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 742
GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE
Sbjct: 342 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 401
Query: 743 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 790
VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 402 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 449
Score = 217 bits (552), Expect = 4e-56
Identities = 172/462 (37%), Positives = 240/462 (51%), Gaps = 49/462 (10%)
Query: 34 NRIIHLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 93
+++ LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY
Sbjct: 32 DKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 91
Query: 94 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 153
GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDE E ++ D
Sbjct: 92 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKT 151
Query: 154 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 213
E E+KSL + E ++ + E+ + +D++K + QE ++
Sbjct: 152 EEMPNDSVLENKSLQENEEEEIGNLEL---AWDMLDLAKIIFKRQE------------TK 196
Query: 214 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQE-ECREKGGQEKQGEVIVSI 272
EA+ AA EV S + E V EE +S Q E ++ E ++ ++
Sbjct: 197 EAQLYAAQAHLKLGEV-SVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAY 255
Query: 273 EEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVL 332
+ ++ V K +E L+ VK + G +K + E +
Sbjct: 256 GYNSQ---YDEAVAQFSKSIEVIENRMAVLNEQVKEAE-GSSAEYKKEIEELKELLPEIR 311
Query: 333 EQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQT 392
E++ ++ ++ S V A +A+ VE+ S PG G + S++ +
Sbjct: 312 EKI--EDAKESQRSGNVAELALKATLVES-STSGFTPG---------GGGSSVSMIASRK 359
Query: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452
P + +S +T+ + VR K P +E S + +A + +V G+ +
Sbjct: 360 PTDGASSSNCVTD------ISHLVRKKRKPEEE----SPRKDDAKKAKQEPEVNGGSGDA 409
Query: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
P + NE ++ EE+ + E+ + E E T E
Sbjct: 410 VP------SGNEVSENMEEEAENQAESRAAVEGTVEAGATVE 445
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 94.4 bits (233), Expect = 4e-19
Identities = 104/404 (25%), Positives = 168/404 (41%), Gaps = 34/404 (8%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 177
E+EE +K + E E E+ ++ R Q + GE+E + E++ + E +KE +
Sbjct: 698 EKEEWKKRDGE---EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754
Query: 178 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGA-APEGPNEAEVTSGKPEQ 236
+ E+G E+++ + EE + K + +E KG +G E E T G+ E+
Sbjct: 755 GK-EEGEGEEVEGEREKEEGERKKE------ERAGKEEKGEEEGDQGEGEEEETEGRGEE 807
Query: 237 EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 296
+ EE V G +V+E E+ +E++GE EE+ E++G E
Sbjct: 808 K----EEGGEVEGGEVEEGKGEREEEEEEGE------------GEEEEGEGEEEEGEGEE 851
Query: 297 VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 356
E E G +E EE E E G+ E+ E E E E
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911
Query: 357 SAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKV 416
E G E+ G+E ++ G G+ E + E E +G G EE
Sbjct: 912 GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG- 970
Query: 417 RAKLVPSQEETKLSVEESEAAGDGVDTK-VAQGATEKSPEDKVQIAANEETQEREEQMKE 475
EE + EE E G+G + + +G E E++ + EE + E E
Sbjct: 971 ----EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026
Query: 476 GEETEGSEEDDKENDKTEEMPNDSV-LENKSLQENEEEEIGNLE 518
GEE EG E+++ ++ EE + EN+ +E EEEE G +
Sbjct: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070
Score = 88.2 bits (217), Expect = 3e-17
Identities = 113/442 (25%), Positives = 174/442 (39%), Gaps = 54/442 (12%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEA-REELREQVYDAMGEKEEAKKTEDKSLAKPETDKE- 175
E+ +G E++ + N +N+ R+E E + D + +K E + + KS+ + E E
Sbjct: 594 EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEG 653
Query: 176 ----------------QDSEMEKG----GREDMDISKSAE--------------EPQEKV 201
QD E EKG GR +M+ E E QE+
Sbjct: 654 RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713
Query: 202 DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGG 261
+ E ++E + G E E + E+E + E ++ G +V+ E ++ G
Sbjct: 714 EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773
Query: 262 QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVV 321
+ K+ E EEK +E ++ E +G E E E + V+ G E EE
Sbjct: 774 ERKK-EERAGKEEKGEEEGDQGEGEEEETEGRGEEKE-EGGEVEGGEVEEGKGEREE--- 828
Query: 322 TSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE-VSEKPGQEAPVLPKDG 380
E E G+ E+ G+ EE E E E E G E E+ G+E ++
Sbjct: 829 --EEEEGEGEEEEGEGE-----EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881
Query: 381 AVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDG 440
G + E + E +G G EE+ K EE + EE E G+G
Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
Query: 441 VD----TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 496
D + +G E E+ E E EE EGEE EG E ++E + EE
Sbjct: 942 EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGE 1000
Query: 497 NDSVLENKSLQENEEEEIGNLE 518
+ E + E EEEE G +E
Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVE 1022
Score = 82.0 bits (201), Expect = 2e-15
Identities = 106/376 (28%), Positives = 153/376 (40%), Gaps = 53/376 (14%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEE--AREELREQVYDAMGEKEEAKKTEDKSLAKP 170
EG EE EGE+ E E E + EE +EE E+ D GE EE ++TE + K
Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD-QGEGEE-EETEGRGEEKE 809
Query: 171 ETDKEQDSEME--KGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG---GAAPEGPN 225
E + + E+E KG RE+ + EE + + + E E KG G EG
Sbjct: 810 EGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE 869
Query: 226 EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 285
E E G+ E+E + E E+ G +EE +G +E +GE EE+ E E+
Sbjct: 870 EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG----EEEEGEGKGEEEG 925
Query: 286 VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL---VGQEVPP 342
E +G E E E D G E EE E E G+ E+ G+E
Sbjct: 926 EEGEGEGEEEEGEGEGEDGE------GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979
Query: 343 AEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIER 402
E E E E E G E E G+E +G G E + +E
Sbjct: 980 EGEEEEGEGEGEEEEGEEEGEEEGE--GEE------EGEGEGEE--------EEEGEVEG 1023
Query: 403 LTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAA 462
E ++G G E +EE + EE E G+G + + E++ +
Sbjct: 1024 EVEGEEGEGEGE---------EEEGEEEGEEREKEGEGEENR------RNREEEEEEEGK 1068
Query: 463 NEETQEREEQMKEGEE 478
+ET E E + ++GEE
Sbjct: 1069 YQETGEEENERQDGEE 1084
Score = 80.5 bits (197), Expect = 6e-15
Identities = 106/450 (23%), Positives = 177/450 (39%), Gaps = 65/450 (14%)
Query: 122 GEKTEDESLVENNDNIDEEAREELRE------QVYDAMGEKEEAKKTE---DKSLAKPET 172
GE T+D +L EN+D+ + E E++E V + + A E D+ + PE
Sbjct: 530 GELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPE- 588
Query: 173 DKEQDSEMEKGGREDMDISKSAEE------PQEKVDLTLDWLTETSEEAKG--------- 217
+KE + + G E+ ++ + E +EK ++ D LT+ +E ++G
Sbjct: 589 EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAE 648
Query: 218 --------GAAPEGPNEAE-------------------VTSGKPEQEVPDAEEEKSVSGT 250
G EG + AE G+ E+E+ + EE K G
Sbjct: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708
Query: 251 DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVD 310
+ +++ RE+G Q+++ + + E+ EE+ E++ E + E V+
Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE--- 765
Query: 311 VGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPG 370
G E EE E AGK + G + EE E E E G EV E G
Sbjct: 766 -GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824
Query: 371 QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS 430
E ++G G++ E + E +G G EE + EE +
Sbjct: 825 -EREEEEEEGEGEEEEGEGEEEEGEGE------EEEGEGKGEEEGEEGEGEEEGEEGEGE 877
Query: 431 VEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQM--KEGEETEGSEEDDKE 488
EE E G+G + +G E+ + + E +E E +EGEE EG E+++
Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937
Query: 489 NDKTEEMPNDSVLENKSLQENEEEEIGNLE 518
+ E+ + E + EEE G E
Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967
Score = 65.5 bits (158), Expect = 2e-10
Identities = 74/269 (27%), Positives = 108/269 (40%), Gaps = 34/269 (12%)
Query: 109 GNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA 168
G +EG VEE +GE+ E+E E + +EE GE+EE + E++
Sbjct: 811 GGEVEGGEVEEGKGEREEEE---EEGEGEEEEGE-----------GEEEEGEGEEEEGEG 856
Query: 169 KPETDKEQDSEMEKG------GREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPE 222
K E + E+ E+G G E+ + EE + + + E E +G E
Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE-------EEEGEGEGEEEGE 909
Query: 223 GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEE 282
G E E GK E+E + E E + + E E G+E++GE EE E EE
Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
Query: 283 QPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP 342
E +G E E E + + G +E E + E G+ E+ EV
Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE------EEGEGEGEEEEEGEVEG 1023
Query: 343 AEESPEVTTEAAEASAVEAGSEVSEKPGQ 371
E E E E E G E EK G+
Sbjct: 1024 EVEGEEGEGEGEEEEGEEEGEE-REKEGE 1051
Score = 63.2 bits (152), Expect = 9e-10
Identities = 86/338 (25%), Positives = 141/338 (41%), Gaps = 39/338 (11%)
Query: 94 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEE------AREELRE 147
G+ E +E G + EEEEGE E+E E + EE EE E
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 148 QVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMDISKSAEEPQEKVDLT 204
+ GE+ E + E++ + E + E + E E+G G E+ + EE + K +
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE-- 922
Query: 205 LDWLTETSEEAKG-GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKG--- 260
E EE +G G EG E E G+ E+E + E E+ + +EE +G
Sbjct: 923 -----EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
Query: 261 ---GQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPE 317
G+E++GE EE+ +E EE+ E +G E E ++ V+ + G+ E
Sbjct: 978 EGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE 1036
Query: 318 EKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 377
E+ E G+ ++ G+E E E E E G E +E+ Q+
Sbjct: 1037 EE----GEEEGEEREKEGEGEENRRNREE----EEEEEGKYQETGEEENER--QDGEEYK 1086
Query: 378 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 415
K + G G + ++ +T T+ G+G E++
Sbjct: 1087 KVSKIKGSVKYGKHKTYQKKS----VTNTQ-GNGKEQR 1119
Score = 30.8 bits (68), Expect = 5.1
Identities = 25/96 (26%), Positives = 37/96 (38%), Gaps = 5/96 (5%)
Query: 686 PGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEE----ESPRKDDAKKAKQEP 741
PG G ++ K DG + H + ++ EE E ++ + ++E
Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748
Query: 742 EVNGGSGDAVPSGNEVSENME-EEAENQAESRAAVE 776
E G G G EV E EE E + E RA E
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 93.6 bits (231), Expect = 6e-19
Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)
Query: 102 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 156
++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+
Sbjct: 447 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 505
Query: 157 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
AKK+ K+ A PE +E+ + E+ G+E+ + E E AK
Sbjct: 506 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 544
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 273
A EG +E E +S K E E + E E G + + + EK +EK EV E
Sbjct: 545 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 603
Query: 274 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 324
EKP++ P +E++G + VE + P K PV+ G P K E
Sbjct: 604 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 663
Query: 325 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 379
+ K+ +E+ VP P EE+ E EV E P +E ++
Sbjct: 664 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 723
Query: 380 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 438
+ P ++P++ + E +T TK LE++ + + P Q+E E+ +A G
Sbjct: 724 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 779
Query: 439 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 498
+G + K K IA N E + +EE +E +E +GS ++++ T +
Sbjct: 780 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 837
Query: 499 SVLENKSLQENEEEEI 514
E K ++EE+ +
Sbjct: 838 PADEKKGGDKSEEKVV 853
Score = 69.7 bits (169), Expect = 1e-11
Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)
Query: 99 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 158
E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE
Sbjct: 505 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 557
Query: 159 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 217
+ + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK
Sbjct: 558 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616
Query: 218 ------------------------------------------------GAAP--EGPNEA 227
G +P + P E
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676
Query: 228 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 287
+ S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++
Sbjct: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 732
Query: 288 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 347
+AES PV +E +VVT ++ K LE+ +E P ++
Sbjct: 733 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 772
Query: 348 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 407
E E + E GS+ K ++ +D AVNG +E + +E+ T+ K
Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 819
Query: 408 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 466
GSG EE+ LS + + GD + KV T EK + A T
Sbjct: 820 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 874
Query: 467 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 502
+ K E E EE K E++ + ++++
Sbjct: 875 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 910
Score = 53.9 bits (128), Expect = 6e-07
Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 426
P + + P V + ++ + E + ETK + S +EE + A V +EE
Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 487
Query: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 486
K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D
Sbjct: 488 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 540
Query: 487 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 544
+ ++D+ EE S E S +E E+E G E A+ + E KE
Sbjct: 541 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 584
Query: 545 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 604
E VE ++ A +E E+ +A + + G + S +E
Sbjct: 585 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
Query: 605 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 664
V E + + + E +G S K +EE K P + +E+AK
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 696
Query: 665 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 724
G + + V+ + + +K + V ++ + K K
Sbjct: 697 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 755
Query: 725 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 784
E K++ K +QE E G+ G E ++ A+ + AV G VE
Sbjct: 756 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 811
Query: 785 VE 786
VE
Sbjct: 812 VE 813
Score = 39.7 bits (91), Expect = 0.011
Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)
Query: 367 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 426
+KP EAP L + + E E LT + + K K ++E
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496
Query: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 474
+ EE E A K ++ +K + EE +E +E K
Sbjct: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556
Query: 475 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 522
EGE+ EG E + E ++ E E K ++E EE EL D
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 604
Score = 32.7 bits (73), Expect = 1.3
Identities = 78/437 (17%), Positives = 162/437 (37%), Gaps = 59/437 (13%)
Query: 390 DQTPIEPQTSIERLTETK-----DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK 444
DQ E + ++E + K D LEE + +EE +L +++EAA +
Sbjct: 151 DQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLR-DDTEAAIRALRKD 209
Query: 445 VAQGATEKSPEDKVQIAANEE-----TQEREEQMKEGEETEGSEEDDKENDKTEEMPNDS 499
+ + + K DK + +E + EE + + S + D + + +
Sbjct: 210 IEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTA 269
Query: 500 VLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA------QLYAAQAHLKLGEV 553
+ E +S E+ ++ + W AK+ ++ KEA ++ + L+ +
Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSI 329
Query: 554 SVES--------ENYVQAVEE--------FQSCLNLQEQYLEAHDRLLAETHYQLGLAYG 597
+ES E + +EE +Q + E L +A +
Sbjct: 330 ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLN 389
Query: 598 YNSQYDEAVAQFSKSIEVIENRMAV-----------------LNEQVKEAEGSSAEYKKE 640
D +A + K +E E R + ++ ++++ + + + K +
Sbjct: 390 VKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQ 449
Query: 641 IEELKELLPEIREKIEDAKESQRSGNVA---ELALKATLVESSTSGFTPGGGGSSVSMIA 697
+ ++E++ E K+ED K A ELA+ + + + +A
Sbjct: 450 HKFVEEIIEET--KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA 507
Query: 698 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 757
++K A++ ++ +K + E + +++ + AK + GGS S E
Sbjct: 508 AKKSPVKATAP----EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563
Query: 758 SENMEEEAENQAESRAA 774
E E E E +AE A
Sbjct: 564 GEQEEGETEAEAEGEEA 580
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 93.6 bits (231), Expect = 6e-19
Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)
Query: 102 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 156
++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+
Sbjct: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 129
Query: 157 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
AKK+ K+ A PE +E+ + E+ G+E+ + E E AK
Sbjct: 130 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 168
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 273
A EG +E E +S K E E + E E G + + + EK +EK EV E
Sbjct: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 227
Query: 274 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 324
EKP++ P +E++G + VE + P K PV+ G P K E
Sbjct: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287
Query: 325 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 379
+ K+ +E+ VP P EE+ E EV E P +E ++
Sbjct: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347
Query: 380 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 438
+ P ++P++ + E +T TK LE++ + + P Q+E E+ +A G
Sbjct: 348 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 403
Query: 439 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 498
+G + K K IA N E + +EE +E +E +GS ++++ T +
Sbjct: 404 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 461
Query: 499 SVLENKSLQENEEEEI 514
E K ++EE+ +
Sbjct: 462 PADEKKGGDKSEEKVV 477
Score = 69.7 bits (169), Expect = 1e-11
Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)
Query: 99 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 158
E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE
Sbjct: 129 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 181
Query: 159 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 217
+ + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK
Sbjct: 182 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
Query: 218 ------------------------------------------------GAAP--EGPNEA 227
G +P + P E
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
Query: 228 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 287
+ S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++
Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 356
Query: 288 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 347
+AES PV +E +VVT ++ K LE+ +E P ++
Sbjct: 357 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 396
Query: 348 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 407
E E + E GS+ K ++ +D AVNG +E + +E+ T+ K
Sbjct: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 443
Query: 408 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 466
GSG EE+ LS + + GD + KV T EK + A T
Sbjct: 444 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498
Query: 467 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 502
+ K E E EE K E++ + ++++
Sbjct: 499 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534
Score = 53.9 bits (128), Expect = 6e-07
Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 426
P + + P V + ++ + E + ETK + S +EE + A V +EE
Sbjct: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
Query: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 486
K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D
Sbjct: 112 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 164
Query: 487 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 544
+ ++D+ EE S E S +E E+E G E A+ + E KE
Sbjct: 165 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 208
Query: 545 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 604
E VE ++ A +E E+ +A + + G + S +E
Sbjct: 209 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
Query: 605 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 664
V E + + + E +G S K +EE K P + +E+AK
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 320
Query: 665 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 724
G + + V+ + + +K + V ++ + K K
Sbjct: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 379
Query: 725 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 784
E K++ K +QE E G+ G E ++ A+ + AV G VE
Sbjct: 380 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435
Query: 785 VE 786
VE
Sbjct: 436 VE 437
Score = 39.7 bits (91), Expect = 0.011
Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)
Query: 367 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 426
+KP EAP L + + E E LT + + K K ++E
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 474
+ EE E A K ++ +K + EE +E +E K
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
Query: 475 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 522
EGE+ EG E + E ++ E E K ++E EE EL D
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 228
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 93.2 bits (230), Expect = 8e-19
Identities = 111/418 (26%), Positives = 168/418 (40%), Gaps = 48/418 (11%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 172
EG+ E EGE + VE EA + +E +A E E+ + E + A+PE+
Sbjct: 1833 EGIEAPEAEGEAQPESEGVE-----APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPES 1887
Query: 173 ------DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNE 226
+ E + + E G E + K A+ E V+ L+ E E++G A E
Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE-ALETEGEDEPESEGAEAQEAEEA 1946
Query: 227 AEVTSG--KPEQEV---PDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
A+ G +PE EV +AEEE DV+ E QE +GE +P+
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA------QPESEDV 2000
Query: 282 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 341
E P E Q E + ES +P G + E + T + E G A E G E P
Sbjct: 2001 EAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE-GDAQPES-DGVEAP 2058
Query: 342 PAEESPEVTTEAAEASAVEAGSEVSEKPGQEA--PVLPKDGAVNGPSVVGDQTPIE---- 395
AEE + + + EA E + QEA P+ V P G+ E
Sbjct: 2059 EAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118
Query: 396 PQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPE 455
P+T E E++ G+E P E E++ +GV+ + A+G + E
Sbjct: 2119 PETEGEAQPESE---GIE-------APEAE------GEAQPESEGVEAQDAEGEAQPESE 2162
Query: 456 DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513
A EE Q E + E E EG + + E + E ++ E + ++ E EE
Sbjct: 2163 GIEAQEAEEEAQPELEGV-EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE 2219
Score = 92.0 bits (227), Expect = 2e-18
Identities = 109/437 (24%), Positives = 179/437 (40%), Gaps = 57/437 (13%)
Query: 113 EGVHVEEEEGE--KTEDESLVENNDNIDEEAREELR---------EQVYDAMGEKEEAKK 161
EGV E EG+ + E E+ E+ D EA E + E ++ E E A+
Sbjct: 1849 EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEA 1908
Query: 162 TEDKSLAKPETDK------EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 215
E + A+PET+ E + E E G E + ++A+E + + + + S+EA
Sbjct: 1909 PEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE--SQEA 1966
Query: 216 KGGAAPEGPN----EAEVTSGKPEQEV-PDAEEEKSVSGTDVQEECREKGGQEKQGEVIV 270
+ A PE + E EV + + E E P++E+ ++ +E E+ E G
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG---- 2022
Query: 271 SIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKA 330
+E +PK EE V E Q T + + ES + E E +V +E EA
Sbjct: 2023 -VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081
Query: 331 V----LEQLVGQEVPPAE--ESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNG 384
++ G+ P +E E+PE EA +A +EA P E P+ +
Sbjct: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA-------PETEGEAQPESEGIEA 2134
Query: 385 PSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS-VEESEAAGD---- 439
P G+ P +E + E + A+ + + +L VE EA G+
Sbjct: 2135 PEAEGEAQP--ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192
Query: 440 --GVDTKVAQGATEKSPE-DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 496
G++ A+G E PE + V+ EE + E + E E EG + + E + E
Sbjct: 2193 SEGIEAPEAEG--EAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250
Query: 497 NDSVLENKSLQENEEEE 513
+ SL + + EE
Sbjct: 2251 GSPQV---SLGDGQSEE 2264
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/278 (24%), Positives = 105/278 (37%), Gaps = 30/278 (10%)
Query: 113 EGVHVEEEEGE--KTEDESLVENNDNIDEEAREELRE---QVYDAMGEKEEAKKTEDKSL 167
EG +E EGE KTE ++ E++ EA EE +E +V +A GE + D
Sbjct: 2030 EGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQE 2089
Query: 168 AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEA 227
A+ E E + + ++ E P+ + E E++G APE EA
Sbjct: 2090 AEGEAQPESEGVEAPEAEGEAQKAEGIEAPETE--------GEAQPESEGIEAPEAEGEA 2141
Query: 228 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQ-------EKQGEVIVSIE--EKPKE 278
+ S E + + E + G + QE E + E +GE E E P+
Sbjct: 2142 QPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEA 2201
Query: 279 VSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV----GGDEPEEKVVTSENEAGKAVLEQ 334
E QP E +G E P + V+ G +PE + T + G +
Sbjct: 2202 EGEAQP----ELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSL 2257
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQE 372
GQ +E S V + G ++PG +
Sbjct: 2258 GDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
Score = 51.2 bits (121), Expect = 4e-06
Identities = 99/433 (22%), Positives = 151/433 (34%), Gaps = 72/433 (16%)
Query: 39 LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEA----------ASLLGKKYGETANEC-G 87
L+V+ E ++ G Q + P A QEA K GE A E G
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG 2039
Query: 88 EAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELRE 147
E G + E +E A E E E ++ E E+ E+ D +EA E +
Sbjct: 2040 ETQKTEGDAQPESDGVE---APEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQP 2096
Query: 148 QVYDAMGEKEEAKKTEDKSLAKPETDKEQ--------------DSEMEKGGREDMDISKS 193
+ + E + + + + PET+ E +++ E G E D
Sbjct: 2097 ESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGE 2156
Query: 194 AEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQ 253
A+ E ++ + E E +G APE EA+ S E + E + + G +
Sbjct: 2157 AQPESEGIE-AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEA- 2214
Query: 254 EECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT------------AVEVEAES 301
E E+ E +G E P+ E QP E QG E +ES
Sbjct: 2215 PEAEEEAQPEPEG------VETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASES 2268
Query: 302 LDPT-----VKPVDVGGDEPEEKVVTSENEA-------GKAVLEQLVGQEVPPAEESPEV 349
P P GGD P ++ + + G + V SP+
Sbjct: 2269 SSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDA 2328
Query: 350 T---TEAAEASAVEAGSEVSEKPGQEAPV---LPKDGAVNGPSVVGDQT--PIEPQTSIE 401
T AE A E S +EAP+ P+ GA G + DQ + P ++
Sbjct: 2329 KSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVG 2388
Query: 402 RLTETKDGSGLEE 414
R DG G ++
Sbjct: 2389 R----ADGFGQDD 2397
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/259 (21%), Positives = 109/259 (42%), Gaps = 39/259 (15%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 178
E+E E+ +E +N +++ A ++E+V + EE K+ + + E + +++
Sbjct: 1273 EDEAERDSEEQRASSN--LEQLAENTVQEEV-----QLEETKEGTEGEGLQEEAVQLEET 1325
Query: 179 EMEKGGRED---MDISKSAE-EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 234
+ E+G +E+ ++ +K E E Q++ + L+ + ET E G EG EV G
Sbjct: 1326 KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE---GLQEEGVQLEEVKEG-- 1380
Query: 235 EQEVPDAEEEKSVSGTDVQEECREKGGQEK---QGEVIVSIEEKPKEVSEEQPVVTLEKQ 291
E + G ++E +E+G E+ G+ + + S+E V E+
Sbjct: 1381 --------PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEA 1432
Query: 292 GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 351
G A + +P G E + + +E + E+ G ++ P E P T
Sbjct: 1433 GRA--------SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484
Query: 352 ----EAAEASAVEAGSEVS 366
E +A + +E S
Sbjct: 1485 MMGQEHTQAQPTQGAAERS 1503
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/198 (22%), Positives = 79/198 (39%), Gaps = 22/198 (11%)
Query: 99 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 158
E ++E G EG+ E + E+T+ E ++ EE +E E + + EE
Sbjct: 1299 EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEE 1358
Query: 159 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGG 218
++T + L + E+ E +GG + ++ EE L E +G
Sbjct: 1359 IEETGGEGLQEEGVQLEEVKEGPEGGLQ----GEALEE----------GLKEEGLPEEGS 1404
Query: 219 AAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKE 278
+ +EA GK QE +EE++ + E C +G +E E P
Sbjct: 1405 VHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP--------TEPPSH 1456
Query: 279 VSEEQPVVTLEKQGTAVE 296
+SE P + + G+ +E
Sbjct: 1457 LSETDPSASERQSGSQLE 1474
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 14/124 (11%)
Query: 401 ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV--------DTKVAQGATEK 452
ER +E + S E++ V QEE +L + G+G+ +TK +G E+
Sbjct: 1277 ERDSEEQRASSNLEQLAENTV--QEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEE 1334
Query: 453 SPE-DKVQIAANEETQEREEQMKEGEET--EGSEEDDKENDKTEEMPNDSVLENKSLQEN 509
+ ++ + E QE E Q++E EET EG +E+ + ++ +E P + L+ ++L+E
Sbjct: 1335 GVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP-EGGLQGEALEEG 1393
Query: 510 EEEE 513
+EE
Sbjct: 1394 LKEE 1397
Score = 35.0 bits (79), Expect = 0.27
Identities = 77/383 (20%), Positives = 136/383 (35%), Gaps = 77/383 (20%)
Query: 401 ERLTETKD-------GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
+RL KD G + ++ K S+ + E+E G+G+ + G
Sbjct: 1750 QRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSG 1809
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513
ED +Q GE G ++D ++D E + E ++ E+E E
Sbjct: 1810 HEDNLQ----------------GEAAAGGDQDPGQSDGAEGIEAPEA-EGEAQPESEGVE 1852
Query: 514 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 573
E + +EA+ GE ESE+ V+A E
Sbjct: 1853 APEAE---------------GDAQEAE----------GEAQPESED-VEAPEAEG----- 1881
Query: 574 QEQYLEAHDRLLAETHYQLGL-AYGYNSQYDEAVAQ-FSKSIEVIENRMAVLNEQVKEAE 631
E E+ D E +++ + G + E AQ ++S+E +E E E+E
Sbjct: 1882 -EAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETE----GEDEPESE 1936
Query: 632 GSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS 691
G+ A+ +E + E + ++ +++E++ ++A VE T G
Sbjct: 1937 GAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQ--EAEGEAQ 1994
Query: 692 SVSMIASRKPTDGASSSNCVTDISHLVRKKRKPE----EESPRKDDAKKAKQEPEVNGGS 747
S +G ++ +PE E P+ + + + E E
Sbjct: 1995 PESEDVEAPEAEGEMQE---------AEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE 2045
Query: 748 GDAVPSGNEVSENMEEEAENQAE 770
GDA P + V EE +AE
Sbjct: 2046 GDAQPESDGVEAPEAEEEAQEAE 2068
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 75.5 bits (184), Expect = 2e-13
Identities = 124/567 (21%), Positives = 229/567 (40%), Gaps = 54/567 (9%)
Query: 117 VEEEEGEKTEDESLVENNDN---IDEEAREELREQ--VYDAMGEKEEAKKT-EDKSLAKP 170
V +EE + T + VE +D ++ AR E R Q + +A+ ++E T D SL+ P
Sbjct: 74 VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP 133
Query: 171 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 230
+ D+ E + + +E QE+ ++ TET VT
Sbjct: 134 SRRMQNDT----AENETTEKEEKSESRQERYEIEE---TET-----------------VT 169
Query: 231 SGKPEQEVPDAEEEKSVSGT-DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 289
+ + DAEE K + +EE + K G + +V V +EEK E EE V++L+
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
Query: 290 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEV 349
+ E + + ++ E E+ EA +A LE + + AE+ ++
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKKI 288
Query: 350 TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG 409
E A A E + E+ +EA + + Q E + +R E +
Sbjct: 289 ADERARIEAEEKAA-AQERERREAEERERMREEEKRAAEERQRIKEEE---KRAAEERQR 344
Query: 410 SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQER 469
EEK A +E ++ EE AA + + + K E K E+
Sbjct: 345 IKEEEKRAA-----EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 470 EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 529
+E +GE+ E E N+K + + L+ L++ EE+ ++ + L K
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQ---EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456
Query: 530 IFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETH 589
FK++E K+ ++ K E E ++++ + F + +++ + T
Sbjct: 457 TFKKEEIKDEKIK------KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 510
Query: 590 YQLGLAYGYNSQYDEAVAQFS--KSIEVIENRMAVL-NEQVKEAEGSSAEYKKEIEELKE 646
+ G +++ E Q K +E + R +E+ ++ + E E+EELK+
Sbjct: 511 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 570
Query: 647 LLPEIREKIEDAKESQRSGNVAELALK 673
E R K+ + +E +R A+ L+
Sbjct: 571 KREE-RRKVLEEEEQRRKQEEADRKLR 596
Score = 56.6 bits (135), Expect = 9e-08
Identities = 94/428 (21%), Positives = 173/428 (40%), Gaps = 77/428 (17%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELR-EQVYDAMGEKEEAKKTEDKSL--------- 167
+EEE E+ DE + +++ ++EE +E E+ E+E K +DK +
Sbjct: 240 QEEEREQGSDE--ISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
Query: 168 ----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG 223
A E ++ + E E+ E+ ++ + +E+ + EE K A
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 224 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEK---------QGEVIVS--- 271
+ E E++ AEEE+ V+E+ R K +EK +GE +
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAK---VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
Query: 272 ---IEEKPKEVSEEQPVVTL---EKQGTAVEVEAESLD---PTVKPVDVGGD------EP 316
+ EK + + Q V E++GT V+ + E L PT K ++ + EP
Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Query: 317 EEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVL 376
+E+V K+ +++ G ++ +T + ++ +PG A V
Sbjct: 475 KEEV--------KSFMDRKKGFTEVKSQNGEFMTHK------LKHTENTFSRPGGRASVD 520
Query: 377 PKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEA 436
K+ A P V E +E L + + EE KL Q+E L +EE +
Sbjct: 521 TKE-AEGAPQV-------EAGKRLEELRRRRGETESEE--FEKLKQKQQEAALELEELKK 570
Query: 437 AGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 496
+ + E+ + + Q A+ + +E EE+ + EE E + E K ++MP
Sbjct: 571 -----KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE--KRQKMP 623
Query: 497 NDSVLENK 504
D + ++K
Sbjct: 624 EDGLSDDK 631
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/309 (22%), Positives = 126/309 (40%), Gaps = 45/309 (14%)
Query: 388 VGDQTPIEPQTSIE------RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV 441
V DQ + Q S+ T T+ E +L +E + ++E+
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 442 DTKVAQGATEKSPEDKVQIAANEETQEREEQMK------EGEETEGSEEDDKENDKTEEM 495
D + + A ET E+EE+ + E EETE + ++ND +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 496 PNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSV 555
N E+K +E EEE+ + + ++ + ++T E+Q LK G++S
Sbjct: 182 ENKK--EDKEKEEEEEEKPKRGSIGENQVE----VMVEEKTTESQEETVVMSLKNGQISS 235
Query: 556 E----SENYVQAVEEFQSCLNLQEQYLEAHD----RLLAETHYQLGLAYGYNSQYDEAVA 607
E E Q +E ++E+ E + RL AE ++ ++ D+ +A
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI------KAEQDKKIA 289
Query: 608 QFSKSIEV--------IENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED-- 657
IE E R A E+++E E +AE ++ I+E ++ E R++I++
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 658 ---AKESQR 663
A+E QR
Sbjct: 350 KRAAEERQR 358
Score = 45.1 bits (105), Expect = 3e-04
Identities = 68/320 (21%), Positives = 124/320 (38%), Gaps = 32/320 (10%)
Query: 467 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDL 526
Q+REE E E DD E + E + E + Q+ EEE +G + D
Sbjct: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE-RLRQKQEEESLG------QVTDQ 65
Query: 527 AKIIFKRQ-ETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLL 585
++ + +EA+ ++ + + E + E Q L + + D +
Sbjct: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 125
Query: 586 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK-EIEEL 644
+ L Q D A + ++ E E+R +++E E + Y+K + +
Sbjct: 126 TDASLSLP---SRRMQNDTAENETTEKEEKSESRQE--RYEIEETETVTKSYQKNDWRDA 180
Query: 645 KELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS-SVSMIASRKPTD 703
+E E +EK E+ +E + G++ E ++ + E +T S I+S +P
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 704 GASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEE 763
+ISH K EEE + +A++A+ E E E E
Sbjct: 241 EEEREQGSDEISH----HEKMEEEDKERAEAERARLEAE-------------ERERIKAE 283
Query: 764 EAENQAESRAAVEGTVEAGA 783
+ + A+ RA +E +A A
Sbjct: 284 QDKKIADERARIEAEEKAAA 303
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 73.6 bits (179), Expect = 7e-13
Identities = 102/427 (23%), Positives = 169/427 (39%), Gaps = 49/427 (11%)
Query: 113 EGVHVEE--EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 170
E V VEE EE + TE+ + E + +EE +EE GE+EEA+ E+++ + P
Sbjct: 453 ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE-------EGGEEEEAEGGEEETKSPP 505
Query: 171 -ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEA-- 227
E + E + +E+ A+ P++ EEAK A + P +A
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEK-------------EEAKSPAEVKSPEKAKS 552
Query: 228 ---EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP 284
E PE + P+ EE KS + E+ + +E + EK K +E+
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612
Query: 285 VVTLEKQGTAVE-----VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQE 339
E + E E +S + P P EK + E E K+ +
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP-EKAKSPEKEEAKS--PEKAKSP 669
Query: 340 VPPAEESPEVTTEAAEASA---VEAGSEVSE--KPGQEAPVLPKDGA-----VNGPSVVG 389
V +SPE +A A +A S V E K ++A K+ A P
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729
Query: 390 DQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGA 449
+TP + ++ ++ ++ + + EK + V S E + EE+ + D K
Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV 789
Query: 450 TE--KSPED-KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 506
E KSPE K + + + E+E KE ++ EE+ + K +E P + E
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA 849
Query: 507 QENEEEE 513
EE+
Sbjct: 850 TPKTEEK 856
Score = 69.7 bits (169), Expect = 1e-11
Identities = 135/659 (20%), Positives = 237/659 (35%), Gaps = 116/659 (17%)
Query: 123 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 182
EK+E E+++ + + EE+ E+ E++EAK+ E K ++E E E
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEE------EEKEAKEEEGK-------EEEGGEEEEA 494
Query: 183 GGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVP 239
G E+ S AEE P+++ + EEAK A + P + E K EV
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAK------SPVKEEAKSPAEAKSPEKEEA---KSPAEVK 545
Query: 240 DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 299
E+ KS + + + K ++++ + P EV + + K+ EA
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAK-------SPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 300 ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 359
+S + PV P E + EA EV E++ T E A++
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA-------EVKSPEKAKSPTKEEAKSPEK 651
Query: 360 EAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAK 419
E E E P P E ++ + + K+ + EK ++
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 420 L---VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 476
+ S E+ K V+E + + V + A KSPE A + E + +
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA--KSPEK----AKSPEKAKTLDVKSPE 765
Query: 477 EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 536
+T EE DK E V E E + E L D K I K++E
Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKE-----EVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 537 KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAY 596
K V+ E Q V+ + +E+ A + +
Sbjct: 821 KSP---------------VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK-------- 857
Query: 597 GYNSQYDEAVAQFSKSIEVIENRMAVLN---EQVKEAEGSSAEYKKEIEELKELLPEIRE 653
+S+ +EA + + +V E + + E EA+ AE KK++ ++ P E
Sbjct: 858 --DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915
Query: 654 KIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTD 713
EDAK ++ + +A ++P D +
Sbjct: 916 VKEDAKPKEK------------------------------TEVAKKEPDDAKAKE----P 941
Query: 714 ISHLVRKKRKPEEESPRKDDAKKAKQEPEVNG-GSGDAVPSGNEVSENMEEEAENQAES 771
+K+ PE++ +++ AKK +++P+ D E S+ E+AE + +
Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 67.4 bits (163), Expect = 5e-11
Identities = 94/415 (22%), Positives = 172/415 (41%), Gaps = 33/415 (7%)
Query: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM 180
E E+ + + V++ + A+EE + EKEEAK + + PE K E
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE--VKSPEKAKSPAKEE 591
Query: 181 EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS---GKPEQE 237
K E K+ +E+ + + EEAK A + P +A+ + K ++
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651
Query: 238 VPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE---EQPVVTLEKQGTA 294
E+E++ S + + + ++ + V E K E ++ ++ + EK +
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 295 VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 354
V+ EA+S + PV PE+ + EA + + +SPE T A
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 355 EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE-----PQTSIERLTETKDG 409
E EA S + P E P V P ++P++ P+ I + E K
Sbjct: 772 E----EARSPADKFP--EKAKSPVKEEVKSPEKA--KSPLKEDAKAPEKEIPKKEEVK-- 821
Query: 410 SGLEEKVRAKLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQIAANEE 465
S ++E+ + + V +E K + EE A + D+K + +++P+ KV+ E+
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE----EK 877
Query: 466 TQEREEQMKEGE-ETEGSEEDDKENDKTEEMPNDSVLENK-SLQENEEEEIGNLE 518
+ E+ KE + E + E +DK+ T E + +E K + E+ E+ E
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932
Score = 62.4 bits (150), Expect = 2e-09
Identities = 92/409 (22%), Positives = 159/409 (38%), Gaps = 46/409 (11%)
Query: 124 KTEDESLVENNDNIDEEAR--------EELREQVYDAMGEKEEAKKTEDKSLAKPETDKE 175
K E +S E + EEA+ E+ + + E+AK E + PE K
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668
Query: 176 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG-KP 234
K + K+ + EK + ++ E+AK E + + S K
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 235 EQEVPDAEE----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 290
E + P+ + E++ S + + K K E +E+ + +++ P EK
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP----EK 784
Query: 291 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP---PAEESP 347
+ V+ E +S + P+ PE+++ E E V E+ QEV P +++
Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEKPQEVKVKEPPKKAE 843
Query: 348 EVTTEAAEASAVEAGSEVSEKPGQEAPVLP----KDGAVNGPSVVGDQTPIE-------- 395
E A + + S+ E P +EAP K+ AV P + E
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903
Query: 396 --PQTSIERLTETKDGSGLEEKVR-AKLVPSQEETK---LSVEESEAAGDGVDTKVAQGA 449
P+ E K+ + +EK AK P + K E+ EAA + DTK +
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA- 962
Query: 450 TEKSPEDKVQIAA----NEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
K PE+K + A +++T +E + E+ E S D+++ K E
Sbjct: 963 --KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE--DKSLAKPETDKE 175
EE + E+E E + EE + EK+++KK E K KP+ +++
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Query: 176 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 235
++ +EK ++ K E ++KV T + E K A P+ + EV +P+
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVP-TPEKEAPAKVEVKEDAKPK--EKTEVAKKEPD 934
Query: 236 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK-EVSEEQPVVTLEKQGTA 294
DA+ ++ + +E EK ++ + E EEKPK E ++ TL K+ +
Sbjct: 935 ----DAKAKEPSKPAEKKEAAPEK--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK 988
Query: 295 VEVE-AESLDPTVKPVDVGGDEPEEKVVTSENEAGK 329
+ E AE T D +P EK + GK
Sbjct: 989 PKAEKAEKSSST----DQKDSKPPEKATEDKAAKGK 1020
Score = 39.3 bits (90), Expect = 0.014
Identities = 94/427 (22%), Positives = 158/427 (37%), Gaps = 94/427 (22%)
Query: 405 ETKDG------SGLEEKVRAKLVPSQEETKLSVEE---------SEAAGDGVDTKVAQGA 449
ET+D S L E +RA+L ++ L EE SEAA V+T + A
Sbjct: 258 ETRDALKCDVTSALRE-IRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAK--VNTDAMRSA 314
Query: 450 TEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPN-----DSVLENK 504
E+ E + Q+ A E + K+ E + SE +D+ D+ L N
Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374
Query: 505 ----SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE-------- 552
+ Q E +++ N+++A D+ A K E +E ++ L E
Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAA--YRKLLEGEECRIGFGPIPFSLPEGLPKIPSV 432
Query: 553 ---VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQF 609
+ V+SE ++ VE+ + + E+ E +Q E V +
Sbjct: 433 STHIKVKSEEKIKVVEKSEKETVIVEEQTE-------------------ETQVTEEVTE- 472
Query: 610 SKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAE 669
E E+ KE EG E + EE + P E KE+
Sbjct: 473 -------EEEKEAKEEEGKEEEGGEEEEAEGGEE-ETKSPPAEEAASPEKEA-------- 516
Query: 670 LALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESP 729
K+ + E + S S ++ P + S + K PE +SP
Sbjct: 517 ---KSPVKEEAKSP----AEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPPEAKSP 567
Query: 730 RKDDAK---------KAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 780
K++AK KAK + S S + ++EEA++ AE+++ V+ +
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 781 AGATVES 787
+ A V+S
Sbjct: 628 SPAEVKS 634
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 73.2 bits (178), Expect = 9e-13
Identities = 99/419 (23%), Positives = 180/419 (42%), Gaps = 50/419 (11%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 178
+++ +K + +E+ N D++A +++ +KE +K D+ AK KE++
Sbjct: 200 QKKNQKNKPGPNIESG-NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE- 257
Query: 179 EMEKGGREDMDISKSA---EEPQEKVDLTLDW--LTETSEEAKGGAAPEGPNEAEVTSGK 233
E+E G ++ +S EE K +T+D + + E+A+ A E NE + K
Sbjct: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK-K 316
Query: 234 PEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 293
+++ +EEK + K QE ++ EE+ ++ EE+ + ++
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK---EEEERQKREEEERIKRLEELE 373
Query: 294 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ--LVGQEVPPAEESPEVTT 351
A E E L+ E E+ E E + + ++ L+ + A E T
Sbjct: 374 AKRKEEERLE----------QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423
Query: 352 EAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG 411
+ +A VE S+ S LPK + + I Q + ++E+ +
Sbjct: 424 KLLQAQGVEVPSKDS---------LPKKRPIYEDK---KRKKIPQQLESKEVSESMELCA 471
Query: 412 LEEKVRAKLVPSQEETKLSVE-----ESEAAG-DGVDTKVAQGATEKSPEDKVQIAANEE 465
E V + VP +EET VE ++E AG D + + TEK +KV I E
Sbjct: 472 AVE-VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN 530
Query: 466 TQEREEQMKEGEETEGSEEDDK--------ENDKTEEMPNDSVLENKSLQENEEEEIGN 516
+E EE+ +E EE E SEE+++ E D+ +E +D K+L + +E+ +
Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS 589
Score = 53.1 bits (126), Expect = 1e-06
Identities = 60/261 (22%), Positives = 115/261 (44%), Gaps = 33/261 (12%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 177
EEEE +K E+E ++ + ++ + +EE R + EK E KK + +KE+
Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLE-----QEKRERKK---------QKEKERK 398
Query: 178 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG---PNEAEVTSGKP 234
++K G+ ++KS E + + + TL L +A+G P P + + K
Sbjct: 399 ERLKKEGKL---LTKSQREARARAEATLKLL-----QAQGVEVPSKDSLPKKRPIYEDKK 450
Query: 235 EQEVPDAEEEKSVSGT---DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 291
+++P E K VS + E E+G EK+ E +E + +E +E+ + E
Sbjct: 451 RKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE-ETPPPVEPEEEEDTEDAGLDDWE-- 507
Query: 292 GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 351
A + E E ++ ++V + EE+ E E + E+ + E E
Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
Query: 352 EAAEASAVEAGSEVSEKPGQE 372
+ ++ ++G + +KP +E
Sbjct: 568 KVSDEK--DSGKTLDKKPSKE 586
Score = 51.2 bits (121), Expect = 4e-06
Identities = 118/572 (20%), Positives = 224/572 (39%), Gaps = 56/572 (9%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE---TDK 174
++ +G+K +++ + D +++ +EL E +A G K + + K E T K
Sbjct: 38 QKSKGKKKKEK---KKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSK 94
Query: 175 EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNE-AEVTSGK 233
++ + +KG ++ D +EE ++K + E G + N+ + GK
Sbjct: 95 DKKKKGQKGKKQSFD-DNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGK 153
Query: 234 PEQEVP--DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 291
++ D EE + ++E R E E ++ + + ++ K
Sbjct: 154 AQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK-----NKP 208
Query: 292 GTAVEVEAESLDPTVKPVDVGGDEPEEKV-VTSENEAGKAVLEQLVGQEVPPAEESPEVT 350
G +E E D + K V + E+K + + KA L +L +E E+
Sbjct: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL--------KEKEELE 260
Query: 351 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD-- 408
T + S + E+ ++ V G + S +TP + E + KD
Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPA-SEEKAETPTAAEDDNEGDKKKKDKK 319
Query: 409 --GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET 466
EEK + K + T +++E+ A K + ++ E++++ E
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALA-----KLKEEEERQKREEEERIKRLEELEA 374
Query: 467 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL------- 519
+ +EE+ E E+ E ++ KE ++ E + + L KS +E L+L
Sbjct: 375 KRKEEERLEQEKRERKKQ--KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432
Query: 520 --AWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQY 577
+ D L + I++ ++ K+ L+ EVS ES AVE + + +E+
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKK-----IPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486
Query: 578 LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKS---IEVIENRMAVLNEQVKEAEGSS 634
+ E GL DE + + IEV EN E+ +E E
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546
Query: 635 AEYKKEIEELKELL--PEIREKIEDAKESQRS 664
+E ++E E E E EK+ D K+S ++
Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578
Score = 48.5 bits (114), Expect = 2e-05
Identities = 118/616 (19%), Positives = 240/616 (38%), Gaps = 86/616 (13%)
Query: 192 KSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 251
K+ E K D+ LD L E A GAA E + K E++ D +E+ + +
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGA--GAAKEQEPQKSKGKKKKEKKKQDFDEDDILK--E 61
Query: 252 VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDP------- 304
++E E G + E + KP E +EE+ + +K+ + + +S D
Sbjct: 62 LEELSLEAQGIKADRETVAV---KPTENNEEE-FTSKDKKKKGQKGKKQSFDDNDSEELE 117
Query: 305 --------TVKP---VDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 353
T KP + G D+ ++ + GKA Q ++ +EE + + +
Sbjct: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA---QKSNKKWDGSEEDEDNSKKI 174
Query: 354 AEASAV----EAGSEVSE----KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTE 405
E S + E+G E E + GQ+ K G P++ + I+ + +
Sbjct: 175 KERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG----PNIESGNEDDDASFKIKTVAQ 230
Query: 406 TKDGSGLEEKVRAKLVPSQEETKL-SVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANE 464
K E+K R + +E+ KL ++E E ++ G ++S + + Q E
Sbjct: 231 KK----AEKKERERKKRDEEKAKLRKLKEKE--------ELETGKKDQSKQKESQRKFEE 278
Query: 465 ETQEREEQMKEG--------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 516
ET + + + G ET + EDD E DK ++ + K +E +E+E
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKK----KKKGEKEEKEKEKKK 334
Query: 517 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHLK-LGEVSVESENYVQAVEEFQSCLNLQE 575
+ + + + K +E +E Q + +K L E+ + + + +E + +E
Sbjct: 335 GPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE 394
Query: 576 ----QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAE 631
+ L+ +LL ++ + + +A S + + + + ++ ++
Sbjct: 395 KERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKI 454
Query: 632 GSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS 691
E KE+ E EL + + E + + VE T G
Sbjct: 455 PQQLE-SKEVSESMELCAAVEVMEQGVPEKEET---------PPPVEPEEEEDTEDAGLD 504
Query: 692 SVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAV 751
+AS + T+ + ++ ++ + EEE +++++ ++E + GS
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGS---- 560
Query: 752 PSGNEVSENMEEEAEN 767
G+E E + +E ++
Sbjct: 561 -EGDEEDEKVSDEKDS 575
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 1/82 (1%)
Query: 115 VHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDK 174
VH+E +E + E+E E ++ + E EE + + G++E+ K +++K K DK
Sbjct: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK-TLDK 581
Query: 175 EQDSEMEKGGREDMDISKSAEE 196
+ EM D D ++ EE
Sbjct: 582 KPSKEMSSDSEYDSDDDRTKEE 603
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/397 (18%), Positives = 157/397 (39%), Gaps = 16/397 (4%)
Query: 274 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG-KAVL 332
+K K SE+ ++ A E+E +P G + +EK +E L
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 333 EQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQT 392
E+L + + V + E + E S+ +K GQ+ D N + D+
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDD--NDSEELEDKD 120
Query: 393 PIEPQTSIERLT------ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVA 446
+T+ ++ + D + L +K + K S ++ S EE E + +
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGS-EEDEDNSKKIKERSR 179
Query: 447 QGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 506
++ +S ++ + + + Q++ ++ K G E EDD + K + + + +
Sbjct: 180 INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE 239
Query: 507 QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 566
++ +EE L + +L + + KE+Q + +K +V+V++ + A EE
Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVK-SKVTVDT-GVIPASEE 297
Query: 567 FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ 626
E E D+ + + G + ++ +++ ++ +A L E+
Sbjct: 298 KAETPTAAEDDNEG-DKKKKDKKKKKG--EKEEKEKEKKKGPSKATVKAMQEALAKLKEE 354
Query: 627 VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 663
+ + E K +EEL+ E E++E K ++
Sbjct: 355 EERQKREEEERIKRLEELEAKRKE-EERLEQEKRERK 390
Score = 36.2 bits (82), Expect = 0.12
Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 103 MENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELR------EQVYDAMGEK 156
ME GV VE EE E TED L + +E E++ E + E+
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535
Query: 157 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDIS 191
EE ++ E+ ++ E ++E +SE +G ED +S
Sbjct: 536 EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570
Score = 36.2 bits (82), Expect = 0.12
Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 119 EEEGEKTEDESL-VENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 177
+EE EK E + +E +N +EE EE E+ D E+EE ++ E + E D++
Sbjct: 512 DEETEKVEGNKVHIEVKENPEEEEEEE-EEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570
Query: 178 SEMEKGGREDMDISKSAEEPQE 199
E + G D SK E
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSE 592
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 72.4 bits (176), Expect = 2e-12
Identities = 94/417 (22%), Positives = 175/417 (41%), Gaps = 53/417 (12%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSL----- 167
E V V++++ KTE + V + +E ++ +V + + K ++K++
Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643
Query: 168 AKPETDKEQDSEMEK--GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN 225
KPE KE+ + +K +ED K E+P+++ E +E K E
Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKE---------EVKKEVKKEIKKEEKK 694
Query: 226 EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 285
E P++EV K V +EE +E +EK+ + I++ PK+ +
Sbjct: 695 E-------PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK--KEIKKLPKDAKKSSTP 745
Query: 286 VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEE----KVVTSENEAGKAVLEQLVGQEVP 341
++ K+ A++ + + +VK V +P+E KV+ E +A +AV +
Sbjct: 746 LSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATT 805
Query: 342 PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI- 400
A + A +EA + P L KD V I+PQ +
Sbjct: 806 AAVMAAAGIAAIGPAKELEAERSLMSSPED----LTKDFEELKAEEVDVTKDIKPQLELI 861
Query: 401 ---ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK 457
E+L ET E V A ++ Q+E +++ +E+ +G+ T +G E++PE+
Sbjct: 862 EDEEKLKET-------EPVEAYVI--QKEREVTKGPAESPDEGITTTEGEGECEQTPEEL 912
Query: 458 VQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
+ E Q ++ K +E G EE + D E+ + E + +E+ EE +
Sbjct: 913 EPV----EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE---EAEEPEEDGEEHV 962
Score = 67.0 bits (162), Expect = 6e-11
Identities = 90/407 (22%), Positives = 175/407 (42%), Gaps = 43/407 (10%)
Query: 119 EEEGEKTEDESLVENNDNID-EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 177
++E K ED++ ++ + EE ++E+++++ K+E KK K + K KE
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI------KKEEKKEPKKEVKKETPPKEVK 710
Query: 178 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP--EGPNEAEVTSGKPE 235
E++K E ++ K +EP++++ + ++AK + P E A + P+
Sbjct: 711 KEVKK--EEKKEVKKEEKEPKKEIK-------KLPKDAKKSSTPLSEAKKPAALKPKVPK 761
Query: 236 QEVPDAEEEKSVSGTDVQEECREK--GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 293
+E ++ ++ SV+ +E+ + K + K E + + + + G
Sbjct: 762 KE--ESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819
Query: 294 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 353
A E+EAE P D+ D E K E + K + QL E +E TE
Sbjct: 820 AKELEAER-SLMSSPEDLTKDFEELKA--EEVDVTKDIKPQLELIE----DEEKLKETEP 872
Query: 354 AEASAVEAGSEVSEKPGQ--EAPVLPKDGAVNGPSVVGDQTPIEPQ--TSIERLTETKDG 409
EA ++ EV++ P + + + +G + P+E Q IE+ + +G
Sbjct: 873 VEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFED--EG 930
Query: 410 SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---EDKVQIAANEET 466
+G EE E K EE+E + + V A++ SP E+ + A+
Sbjct: 931 AGFEESSET----GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986
Query: 467 QEREEQMKEGEETEGSEEDDK-ENDKTEEMPNDSVLENKSLQENEEE 512
+E+ E + G++ + D+ E + E+ ++ E+K+ EEE
Sbjct: 987 REKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033
Score = 54.3 bits (129), Expect = 4e-07
Identities = 102/424 (24%), Positives = 172/424 (40%), Gaps = 59/424 (13%)
Query: 144 ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR-EDMDISKSAEEPQEKVD 202
+L+++ K AK KS+ K KE+ E+ K E +S E+ K D
Sbjct: 534 KLKQRADSRESLKPAAKPLPSKSVRKES--KEETPEVTKVNHVEKPPKVESKEKVMVKKD 591
Query: 203 LTLDWLTETSEEAKGGAAPEGPN--EAEVTSGKPEQEVPDAEEEKSVS-----GTDVQEE 255
+ T+ S K + E P+ +AEV + P A +EK+V + ++E
Sbjct: 592 KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKE 651
Query: 256 CREKGGQE---KQGEVIVSIEEKPK--EVSEE-----------QPVVTLEKQGTAVEVEA 299
+EK +E K+ + + EEKPK EV +E +P ++K+ EV+
Sbjct: 652 EKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKK 711
Query: 300 ESLDPTVKPVDVGGDEPEEKVVTSENEAGK-------AVLEQLVGQEVPPAEESPEVTTE 352
E K V EP++++ +A K A + +VP EES + +
Sbjct: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV 771
Query: 353 AAEASAVEAGSEVSEKPGQEAPVLPK---DGAVN-------GPSVVGDQTPIEPQTSIER 402
AA + +V +K G+ A + GA G + +G +E + S+
Sbjct: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831
Query: 403 LTE--TKDGSGLEE---------KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 451
E TKD L+ K + +L+ +E+ K E EA + +V +G E
Sbjct: 832 SPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLK-ETEPVEAYVIQKEREVTKGPAE 890
Query: 452 KSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK---TEEMPNDSVLENKSLQE 508
SP++ + E E+ + E E +G ++ +K D+ EE E K+ E
Sbjct: 891 -SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949
Query: 509 NEEE 512
EE
Sbjct: 950 EAEE 953
Score = 44.3 bits (103), Expect = 4e-04
Identities = 98/430 (22%), Positives = 160/430 (37%), Gaps = 85/430 (19%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 172
EG+ E EGE E E + ++++ +++ E+ D EE+ +T D K ET
Sbjct: 894 EGITTTEGEGEC---EQTPEELEPVEKQGVDDI-EKFEDEGAGFEESSETGDYE-EKAET 948
Query: 173 DKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLD-WLTETSEEAKGG--AAPEGPNE 226
E+ E E+ G E + +S S P +E D ++ E E G A E +E
Sbjct: 949 --EEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDE 1006
Query: 227 AEVTSGKPEQEVPDAEEEKSVSGTDVQE-----------------ECREKGGQEKQ-GEV 268
A + G+ EQ +A+EE +E + E GG E+Q G +
Sbjct: 1007 A-IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFL 1065
Query: 269 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 328
++ + +P ++ + E+E+ T + D+PEE TS G
Sbjct: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEA---TASDEENREDQPEEFTATS----G 1118
Query: 329 KAVLEQLVGQEVPPAEE--------SPEVTTEAAEASAVE-------AGSEVSEKPGQEA 373
+ E P +E S E E E+ + E S S++ + A
Sbjct: 1119 YTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178
Query: 374 PVLPKDG--------AVNGPSVVGDQTPIEPQTSIER------------LTETKDGSGLE 413
V P +G A +G + I P +S+E +E K + L+
Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238
Query: 414 ----------EKVRAKLVPSQEETKLSVEESEAAGD-GVDTKVAQGATEKSPEDKVQIAA 462
EKV PS + S E G+ V+ + + S E +V +
Sbjct: 1239 IKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVS 1298
Query: 463 NEETQEREEQ 472
E TQE E+
Sbjct: 1299 PEVTQEVVEE 1308
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/110 (31%), Positives = 52/110 (47%), Gaps = 9/110 (8%)
Query: 413 EEKVRAKL-VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREE 471
+EKV K P + ETK SV E E + V EK D AA E+T ++E
Sbjct: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642
Query: 472 QMKEGEETEGSEEDDKE----NDKT----EEMPNDSVLENKSLQENEEEE 513
++K ++ E E+ KE DKT EE P ++ + +E ++EE
Sbjct: 643 KVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEE 692
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 71.6 bits (174), Expect = 3e-12
Identities = 121/557 (21%), Positives = 225/557 (40%), Gaps = 49/557 (8%)
Query: 120 EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETD-KEQDS 178
+E E E E + + E LREQ M E+EE ++K L + E + +EQ+
Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMWRQEKRLREQEKELREQEK 335
Query: 179 EMEKGGREDMDISKSAEEPQEKVDLTLDWLTE---TSEEAKGGAAPEGPNEAEVTSGKPE 235
E+ RE ++ + E+ QE+ + W E +E K E E E + E
Sbjct: 336 EL----REQKELREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 236 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 295
Q++ D EE + E REK + ++ E + EK +E + Q
Sbjct: 390 QKMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKMREEKKMQ------------ 433
Query: 296 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 355
E E ++ D K + EK + E E + E++ QE E+ + +
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 356 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEE 414
E E + QE + ++ + + Q + E++ E +D EE
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE--KKMWRQEKMREQEDQMWEQEE 551
Query: 415 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 474
K+R QE+ EE K Q +K+ + + ++ E +ERE++M+
Sbjct: 552 KMR-----DQEQKMWDQEERM-------EKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Query: 475 EGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFK 532
E EE E E+ ++ +K +E + + +QE EE+ E W+ + +++
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ---EEKMWE 656
Query: 533 RQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQL 592
+Q E Q H K+ E E + E+ + QEQ + D+ +
Sbjct: 657 QQRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 593 GLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIR 652
+ +E + + + ++ E +M E++ E E E ++++ E ++ LPE +
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE-QQRLPEQK 774
Query: 653 EKIEDAKESQRSGNVAE 669
EK+ + ++ Q + E
Sbjct: 775 EKLWEHEKMQEQEKIWE 791
Score = 46.2 bits (108), Expect = 1e-04
Identities = 79/408 (19%), Positives = 168/408 (41%), Gaps = 73/408 (17%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELRE--QVYDAMGEKEEAKKTEDKSLAKPETDKE 175
E+EE + +++ + + + ++++ +E+ ++ + M E+E ++ E K + E +E
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607
Query: 176 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 235
Q+ +M++ + + + E +EK+ +E K E E E + +
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQ---------EQEEKMWEQEEKMWEQEEKMWE-Q 657
Query: 236 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 295
Q +P+ ++EK +QE+ + + +EK E +EK ++ ++EQ T +++
Sbjct: 658 QRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWE-----QEKMEKKTQEQEKKTWDQEKMR- 710
Query: 296 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 355
E ES+ EK + E E + E++ QE E+ E+ +
Sbjct: 711 --EEESM------------REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE-- 754
Query: 356 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 415
E E EK ++ +RL E K+ EK
Sbjct: 755 ----EKMWEQEEKMWEQ----------------------------QRLPEQKEKLWEHEK 782
Query: 416 VRAKLVPSQEETKLSVEESEAAGD-----GVDTKVAQGATEKSPEDKVQIAANEETQERE 470
++ + ++E K+ +E + G G + K+ +G EK + ++ EE +
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM-RGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 471 EQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 518
E+ G+E + E+ + +K E + + ++E EE+ G E
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 42.7 bits (99), Expect = 0.001
Identities = 80/366 (21%), Positives = 140/366 (38%), Gaps = 64/366 (17%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 172
E + E E + E+E ++ + +E E+++EQ ++E+ ++ E+K + E
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 173 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 232
EQ+ +M + R E +EK+ W E +E +
Sbjct: 647 MWEQEEKMWEQQR--------LPEQKEKL-----WEHEKMQEQE---------------K 678
Query: 233 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQG 292
EQE E+EK T QE+ ++ QEK E S+ E+ K++ EE+ + + +Q
Sbjct: 679 MQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREE-ESMREREKKMREEEEM--MREQE 733
Query: 293 TAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE 352
++ + E + E EE++ E + + + Q +P E E E
Sbjct: 734 EKMQEQEEKM-----------QEQEEEMWEQEEKMWEQEEKMWEQQRLP---EQKEKLWE 779
Query: 353 AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 412
+ E E EK + + G + + Q R E K G
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQE-----------EKMRGQEEKMRGQEEKMRGQEEKMW-GQ 827
Query: 413 EEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQ 472
EEK+ QEE EE + + QG EK E + ++ EE +E+
Sbjct: 828 EEKMW-----GQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
Query: 473 MKEGEE 478
G+E
Sbjct: 883 KMRGQE 888
Score = 42.4 bits (98), Expect = 0.002
Identities = 66/312 (21%), Positives = 129/312 (41%), Gaps = 52/312 (16%)
Query: 400 IERLTETKDGSGLE--------EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 451
IE LT+ +D LE E+++ K QE KL + ESE + ++ K + E
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQE--KLPLAESEKSEIQLNVKELKRKLE 256
Query: 452 KSPEDKVQIAAN---EETQEREEQMKEGE------------------ETEGS--EEDDK- 487
++ Q+ N EE +EE+++E E E EG E+++K
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316
Query: 488 --------ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA 539
E +K + E K L+E EE+ E W+ + + ++ +E
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376
Query: 540 QLYAAQAHLKLGEVSVESE-----NYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ--- 591
+L+ + ++ E + + + + E + + QE+ E +++ E Q
Sbjct: 377 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE 436
Query: 592 -LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPE 650
Q +E + + K + E M E++++ E + E ++E E ++ LPE
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE-QEEKEWQQQRLPE 495
Query: 651 IREKIEDAKESQ 662
+EK+ + ++ Q
Sbjct: 496 QKEKLWEQEKMQ 507
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 70.5 bits (171), Expect = 6e-12
Identities = 142/656 (21%), Positives = 269/656 (41%), Gaps = 99/656 (15%)
Query: 75 LGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTE--DESLVE 132
L ++ ET+ E G + K+ +L + +L +E +EEE GEK E L +
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616
Query: 133 NNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMD 189
+ + + E+ ++ + + +EE K+ + + ++ + +D E+EK R + D
Sbjct: 617 ARASAGDTRQVEVLKK--ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEAD 674
Query: 190 ISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSG 249
+ EE ++ TL L + EEA ++A++ + E E + ++
Sbjct: 675 RGRELEEQNLQLQKTLQQLRQDCEEA---------SKAKMVA---EAEATVLGQRRAAVE 722
Query: 250 TDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPV 309
T ++E E ++ I+ +E++ KE L G AVE L ++ +
Sbjct: 723 TTLRETQEENDEFRRR---ILGLEQQLKETR------GLVDGGEAVEAR---LRDKLQRL 770
Query: 310 DVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE----- 364
+ + EE + S+ E G + A+ + E E A+ G E
Sbjct: 771 EAEKQQLEEALNASQEEEG----------SLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Query: 365 -VSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTETKDGS---------GLE 413
E+ G++ VL + A + + D+T +E++ E + +
Sbjct: 821 RALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYK 880
Query: 414 EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET----QER 469
EK R ++ +Q + K E+E G+ Q ++ + A +T +E
Sbjct: 881 EKARREVADAQRQAKDWASEAEKTSGGLSR--LQDEIQRLRQALQASQAERDTARLDKEL 938
Query: 470 EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENK--SLQENEEEEIGNLELAWDMLDLA 527
Q +G E E + ++D+ ++ LE K L+ +EE +EL D ++
Sbjct: 939 LAQRLQGLEQEAENKKRSQDDRARQLKG---LEEKVSRLETELDEEKNTVELLTDRVNRG 995
Query: 528 KIIFKRQETKEAQLYAAQAHLKLGEVSVESEN-----YVQAVEEFQ----SCLNLQEQYL 578
+ + T+ Q +A+ L+ ++S+E +N + + E FQ S L+ Q
Sbjct: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ 1055
Query: 579 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIE-----------VIENRMAVLNEQV 627
+RL AE + L N + + V + S IE + R+ L QV
Sbjct: 1056 LLQERLQAEEREKTVL-QSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114
Query: 628 KEAE-------GSSAEYKKEIEELKELLPEIREKIED-AKESQR--SGNVAELALK 673
EAE G + ++E+EE E+ +++ +I+ K+S R S + AE ALK
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALK 1170
Score = 34.3 bits (77), Expect = 0.46
Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 17/302 (5%)
Query: 385 PSVVGDQTPIEPQTSIERLTET-----KDGSGLEE-----KVRAKLVPSQEETKLSVEES 434
P ++ DQ P S++ + T ++GS E KV L Q +S +
Sbjct: 296 PDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355
Query: 435 EA-AGDGVDTKVAQGATEKSPEDKVQIAANEETQER-EEQMKEGEETEGSEEDDKENDKT 492
+A AG G T+ + K E+ + E +Q E Q++E E ++ E K
Sbjct: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415
Query: 493 EEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 552
E ++ L+N ++ E++ + L +++L + Q + A+ + L+ E
Sbjct: 416 EAQQSNKELQNMKRLLDQGEDLRH-GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474
Query: 553 VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGY-NSQYDEAVAQFSK 611
+ E Q VEE L L+E+ L A L E + QY Q +
Sbjct: 475 LLEEVLEGKQRVEEQ---LRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531
Query: 612 SIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELA 671
S++ AVL + ++ ++E+EE E + + KE R+ L
Sbjct: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591
Query: 672 LK 673
L+
Sbjct: 592 LR 593
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 68.2 bits (165), Expect = 3e-11
Identities = 106/493 (21%), Positives = 197/493 (39%), Gaps = 66/493 (13%)
Query: 118 EEEEGEKT---EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK----- 169
EEEEG+ ++ NN N D +E + + + K+ K + L+K
Sbjct: 1204 EEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNK 1263
Query: 170 -------------PETDKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLDWLTETSE 213
PET E D ++ +++ K++ P +E+V T + L E
Sbjct: 1264 ERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEE 1323
Query: 214 EAKGGA-APEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSI 272
+ AP PN + KPE ++ EEE+ + +EE E+G +E+ G +
Sbjct: 1324 NRREETCAPVSPNTSP--GEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKD 1381
Query: 273 EEKPKEVSEEQPVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEKVVTSE--- 324
+ K +E+P ++ EK+ +A E E E +P+ DE + + ++E
Sbjct: 1382 PDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEK 1441
Query: 325 ----NEAGKAVLEQ---LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 377
E+ K VLE + V P +PEV + SE E G + +P
Sbjct: 1442 EELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAG-DPEAVP 1500
Query: 378 KDGAVNGPSVVGDQTPIEPQTSIERL-TETKDGSGLEEKVRAKLVPS-QEETKLSVEESE 435
+ P G+Q + Q + + + TE K+G+ ++ ++ V + Q T+ S E+ +
Sbjct: 1501 ESDEEPPP---GEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDD 1557
Query: 436 AAGDGVDTKVAQGATEK--SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTE 493
D +T+ A + + + QIA T + +Q ++ ++
Sbjct: 1558 TFQDCAETQEACRSLQNYTRADQSPQIAT---TLDDCQQSDHSSPVSSVHSHPGQSVRSV 1614
Query: 494 EMPNDSVLENKSLQENEEE------EIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAH 547
P+ LEN Q + ++ + N+E + M+D+ + + +Q
Sbjct: 1615 NSPSVPALENSYAQISPDQSAISVPSLQNMETS-PMMDVPSV------SDHSQQVVDSGF 1667
Query: 548 LKLGEVSVESENY 560
LG + +ENY
Sbjct: 1668 SDLGSIESTTENY 1680
Score = 55.5 bits (132), Expect = 2e-07
Identities = 104/488 (21%), Positives = 192/488 (39%), Gaps = 88/488 (18%)
Query: 159 AKKTEDKSLAKPETDK--EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
A +E++ A+ E ++ EQ S EK +E + ++ + KV +L
Sbjct: 995 AAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPV 1054
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
G E E++ E+E + E+E+ + +EE E+ +E++ E +I+ P
Sbjct: 1055 TG---ERGQLLELSKESSEEE-EEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110
Query: 277 KEVSEEQ--------PVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEK---- 319
+++ Q P V +K+G V E++ T + ++ D +E+
Sbjct: 1111 PRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMP 1170
Query: 320 ------VVTSENEAGKAVLEQLV----GQEVPPAEE-----------SPEVTTEAAEASA 358
+ E + K VL + G++ EE P ++S
Sbjct: 1171 QLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSN 1230
Query: 359 VEAGSEVSEKPGQEAPVLPKDGAVNGPS----------------VVGDQTPIEP--QTSI 400
++ GS+ + +P + V PK G G S +TP+EP Q ++
Sbjct: 1231 LKEGSKDNPEPLKCKQVWPK-GTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTV 1289
Query: 401 ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQI 460
E ET +G +R + + L +E + + + PED + I
Sbjct: 1290 EEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDL-I 1348
Query: 461 AANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 520
EE +E EE+ +E EE EG EE+ N E+ P + QE EE EI
Sbjct: 1349 KPEEEEEEEEEEEEEEEEEEGEEEEGGGN--VEKDP-----DGAKSQEKEEPEIST---- 1397
Query: 521 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAV---------EEFQSCL 571
+ D A++ +E +E + +H + + E ++++++ E F+ L
Sbjct: 1398 -EKEDSARLDDHEEEEEEDE---EPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVL 1453
Query: 572 NLQEQYLE 579
QE +L+
Sbjct: 1454 ENQETFLD 1461
Score = 54.3 bits (129), Expect = 4e-07
Identities = 98/428 (22%), Positives = 171/428 (39%), Gaps = 74/428 (17%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET----D 173
EEEE E+ E+E E + DEE EE E+ E+EE ++ L KP++
Sbjct: 1070 EEEEEEEDEEEEEEEEEEEEDEEEEEEEEEE------EEEENIQSSPPRLTKPQSVAIKR 1123
Query: 174 KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGK 233
K +K GR+ I+ S +T + ++ET+E NE S +
Sbjct: 1124 KRPFVLKKKRGRKRRRINSS---------VTTETISETTEVL---------NEPFDNSDE 1165
Query: 234 PEQEVPDAEEEKSVSGTDVQEECRE----KGGQEKQGEVIVSIEEKPKE---VSEEQPVV 286
E+ +P E + +V+E+ R+ K Q + G+ + EE+ K+ P
Sbjct: 1166 -ERPMPQLEPTCEI---EVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCR 1221
Query: 287 TLEKQGTAVEVEAESLDPTVKPVDVGGDEPE-EKVVTSENEAGKAVLEQLVGQEVPPAEE 345
++ E +P +P+ P+ K S+ K E+ G ++
Sbjct: 1222 NNMNDDSSNLKEGSKDNP--EPLKCKQVWPKGTKRGLSKWRQNK---ERKTGFKL-NLYT 1275
Query: 346 SPEVTTEAAEASAVEAGSEVSEKPGQEAPV-LPKDGAVNGPSVVGDQTPIEPQTSIERLT 404
PE E E VE E SE +P+ + ++ G +++ + +T
Sbjct: 1276 PPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSP 1335
Query: 405 ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---------- 454
T G E+ + + P +EE + EE E + + + G EK P
Sbjct: 1336 NTSPGEKPEDDL---IKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEE 1392
Query: 455 -------EDKVQIAANEETQEREEQMKEGEETEGSEEDDKEND----KTEEMPNDSVLEN 503
ED ++ +EE +E +E+ E+ + +EDD + + EE+P +S
Sbjct: 1393 PEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESF--- 1449
Query: 504 KSLQENEE 511
K + EN+E
Sbjct: 1450 KEVLENQE 1457
Score = 33.1 bits (74), Expect = 1.0
Identities = 15/60 (25%), Positives = 31/60 (51%)
Query: 717 LVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 776
L++ + + EEE +++ ++ + E E GG+ + P G + E E E + E A ++
Sbjct: 1347 LIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLD 1406
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 66.6 bits (161), Expect = 8e-11
Identities = 116/561 (20%), Positives = 233/561 (41%), Gaps = 69/561 (12%)
Query: 144 ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS----------EMEKGGREDMDISKS 193
++ Q + M ++EE K +K LA E ++ ++++ + + ++
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 194 AEEPQEKVDLTLDWLTETSE--EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 251
AEE + ++ L E EA+ E + K +Q + + EE+ +
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ-----LE 953
Query: 252 VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 311
+E R+K EK V+ E K K++ EEQ + LE Q + E + L+ +
Sbjct: 954 EEESARQKLQLEK-----VTTEAKLKKLEEEQ--IILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 312 GGDEPEEKV-----VTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVS 366
E EEK + +++EA LE+ + +E +E E T E + + +++
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL-EKTRRKLEGDSTDLSDQIA 1065
Query: 367 EKPGQEAPV----LPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG-SGLEEKV---RA 418
E Q A + K+ + ++ + +++++ E + S L+E + RA
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 419 KLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQI---AANEETQEREE 471
++++ + EE EA D +D+ AQ E +V I EE + E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 472 QMKEGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 529
Q++E + ++ EE ++ ++T+ + ++ + K ENE E+ N E+ +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELAN-EVKVLLQGKGDS 1243
Query: 530 IFKRQETKEAQLYAAQAHLKLGE------------VSVESENYVQAVEEFQSCLNLQEQY 577
KR++ EAQL Q GE + VE +N + + S + +
Sbjct: 1244 EHKRKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 578 LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEY 637
A + L +T L + + S ++ +E+ EQ++E E +
Sbjct: 1303 FSALESQLQDTQELL-------QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Query: 638 KKEIEELKELLPEIREKIEDA 658
+K+I L + ++++K+ED+
Sbjct: 1356 EKQIATLHAQVADMKKKMEDS 1376
Score = 60.1 bits (144), Expect = 8e-09
Identities = 124/620 (20%), Positives = 241/620 (38%), Gaps = 128/620 (20%)
Query: 139 EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQ 198
E+ + REQ + E+EEAK +K +A T Q ++M+K + + ++AEE +
Sbjct: 1335 EDEKNSFREQ----LEEEEEAKHNLEKQIA---TLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 199 EKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDA----------------- 241
K+ L+ L++ EE ++ E T + +QE+ D
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAY-----DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 242 --------EEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 293
EEK++S +E R + ++ +S+ +E E++ LE+
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK--AELERLNK 1500
Query: 294 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 353
E E L + DVG E E K LEQ V +E+ E E +A
Sbjct: 1501 QFRTEMEDLMSSKD--DVGKS-------VHELEKSKRALEQQV-EEMKTQLEELEDELQA 1550
Query: 354 AEASAVEAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 412
E + + + Q E + +D +Q+ + + + ++ E +
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDLQGRD----------EQSEEKKKQLVRQVREMEAELED 1600
Query: 413 EEKVRAKLVPSQEETKLSVEESEAAGDGVDT----------------KVAQGATEKSPED 456
E K R+ V ++++ ++ +++ EA D + K + +
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 457 KVQIAANEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----V 500
+ +I A + E++ + E E + EE + ++ +E+ N S
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720
Query: 501 LENK--------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 552
LE K L+E EEE GN EL D L A + + T L ++H +
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT---DLNLERSHAQ--- 1774
Query: 553 VSVESENYVQAVEEFQSCLNLQEQYLE------------AHDRLLAETHYQLGLAYGYNS 600
++EN Q +E L ++ Q +E A + +A+ QL N
Sbjct: 1775 ---KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD-----NE 1826
Query: 601 QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 660
+ A K + E ++ + QV + ++ +YK + ++ L +++ ++E+A+E
Sbjct: 1827 TKERQAA--CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Query: 661 SQRSGNVAELALKATLVESS 680
+ N + L+ L +++
Sbjct: 1885 EAQRANASRRKLQRELEDAT 1904
Score = 40.4 bits (93), Expect = 0.006
Identities = 57/283 (20%), Positives = 112/283 (39%), Gaps = 28/283 (9%)
Query: 521 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQS-----CLNLQE 575
W + K + + +E + + +K+ E + +EN + +E QS L LQE
Sbjct: 828 WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887
Query: 576 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 635
Q L+A L AE + +E +E E R L + K+ + +
Sbjct: 888 Q-LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 636 EYKKEIEE---------LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP 686
E ++++EE L+++ E + K + ++ +LA + L+E + FT
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 687 GGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGG 746
+ K + +TD+ +R++ K +E +K +++ E
Sbjct: 1007 NLTEEEEKSKSLAKLKN--KHEAMITDLEERLRREEKQRQE------LEKTRRKLE---- 1054
Query: 747 SGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTA 789
GD+ ++++E + AE + + E A A VE A
Sbjct: 1055 -GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 66.6 bits (161), Expect = 8e-11
Identities = 87/387 (22%), Positives = 166/387 (42%), Gaps = 34/387 (8%)
Query: 116 HVEEEEG-----EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 170
H E+E+G EK + E + + I+++ + E + + K A+K+E+K+ K
Sbjct: 164 HKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKT-AEKSEEKT--KK 220
Query: 171 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN---EA 227
E + ++++ + ++ K+ +P+EK D +++ ++ + +
Sbjct: 221 EVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHG 280
Query: 228 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 287
++ G+ P E++ T EK G++K+ E V+ E K KE ++ +
Sbjct: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE---KEDIKK 337
Query: 288 LEKQGTAVEVE-------AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEV 340
++ TA++VE +E+ TVK + +EK S+ A +EQ G++
Sbjct: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ 397
Query: 341 PPAEESPEVTTEAAEASAVEAGSEV---SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 397
E+ E + +V + +V +E+ +E + AV G +E +
Sbjct: 398 EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE 457
Query: 398 TSIERLTET----KDGS---GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK--VAQG 448
E+ +T KD G EEKV A L + ETK E+ AG V K QG
Sbjct: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD-EKMSKAGKEVKPKPPQLQG 516
Query: 449 ATEKSPEDKVQIAANEETQEREEQMKE 475
E+ PE +++ A E+ + K+
Sbjct: 517 KKEEKPEPQIKKEAKPAISEKVQIHKQ 543
Score = 45.8 bits (107), Expect = 2e-04
Identities = 61/272 (22%), Positives = 118/272 (43%), Gaps = 34/272 (12%)
Query: 124 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE------TDKEQD 177
K ++ + ++ ++ + + +V G+K+E K+ + P+ +DK+
Sbjct: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423
Query: 178 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 237
++ E+ E +S P +K + T + + + K G + E GK E++
Sbjct: 424 AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK-EEK 482
Query: 238 VPDAEEEKSVSGTDVQEECREKGGQE---KQGEVIVSIEEKPK-EVSEEQPVVTLEKQGT 293
VP + +EK ++E K G+E K ++ EEKP+ ++ +E EK
Sbjct: 483 VPASLKEKEPE--TKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK--- 537
Query: 294 AVEVEAESLDPTVKPVDVGGDEPEEKV------VTSENEAGKAVLEQLVGQEVPP----- 342
V++ + + K V G +PEEKV VT E A ++ +E P
Sbjct: 538 -VQIHKQDIVKPEKTVSHG--KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKT 594
Query: 343 --AEESPEVTTEAAEASAVEAGSEVSEKPGQE 372
+ +P+ T+E E+ + +E+SEK +E
Sbjct: 595 DKPKPTPKGTSEVTESG--KKKTEISEKESKE 624
Score = 37.7 bits (86), Expect = 0.042
Identities = 73/363 (20%), Positives = 136/363 (37%), Gaps = 39/363 (10%)
Query: 433 ESEAAGDGVDTKVAQGATEKSPEDKVQIAANE-ETQEREEQMKEGEETEGSEEDDKENDK 491
E E DG D +G ++ P K +I ++ E QE+ E+ + + T +E KE +
Sbjct: 117 EDEEDDDG-DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175
Query: 492 TEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA------Q 545
+E P + +++ E+ E L AK K +E + ++ Q
Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKK---AKTAEKSEEKTKKEVKGGKQEKVKQ 232
Query: 546 AHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLE-AHDRLLAETHYQLGLAYGYNSQYDE 604
K+ EV + ++ ++ ++ EQ + A R + + L G +
Sbjct: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292
Query: 605 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI-EELKELLPEIREKIEDAKESQR 663
+ S R + ++E EG + +K++ E K+ +EK + K+S++
Sbjct: 293 PLPTEQAS------RPTPASPALEEKEGEKKKAEKKVTSETKK-----KEKEDIKKKSEK 341
Query: 664 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 723
E A+ E + T G + A++K S +K +
Sbjct: 342 -----ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK--------TKKPAE 388
Query: 724 PEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAE--NQAESRAAVEGTVEA 781
E+ +K + K+ EP + +VPS +V E E + AV G E
Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448
Query: 782 GAT 784
T
Sbjct: 449 KTT 451
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 66.2 bits (160), Expect = 1e-10
Identities = 119/602 (19%), Positives = 230/602 (38%), Gaps = 109/602 (18%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 177
+EEE E+ ED E +DEE E + + G + K +DK +++++
Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKK------EEKEE 4836
Query: 178 SEMEKGGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 234
+E + GG+ + I++ +E + +VD P N+ +V P
Sbjct: 4837 AEADDGGQGEDKINEQIDERDYDENEVD------------------PYHGNQEKV----P 4874
Query: 235 EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 294
E E D ++ ++ D + + +E + E + I+EKP+E E E++G
Sbjct: 4875 EPEALDLPDDLNLDSED-KNGGEDTDNEEGEEENPLEIKEKPEEAGHE-----AEERGET 4928
Query: 295 VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 354
+ ES P EPEE + G+ ++ + A + PE +E
Sbjct: 4929 ETDQNESQSP---------QEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQ 4979
Query: 355 EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEE 414
+ S E E E+ G+ NGP+ G Q P E + + TE + LE
Sbjct: 4980 QQSVEEKDKEADEEGGE-----------NGPADQGFQ-PQEEEEREDSDTEEQVPEALER 5027
Query: 415 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQ-----GATEKSPEDK------VQIAAN 463
K A + E + + E AG + + + GA + + + Q+A+
Sbjct: 5028 KEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQ 5087
Query: 464 EETQEREEQMKE-----GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 518
+ T++ + K E + +++ + + + DS E Q+ + +
Sbjct: 5088 KHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQV----- 5142
Query: 519 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCL---NLQE 575
+ D + I + + +AQ Y + K + S + Q EE + L QE
Sbjct: 5143 ---EDADAFEHIKQGSDAYDAQTYDVAS--KEQQQSAKDSGKDQEEEEIEDTLMDTEEQE 5197
Query: 576 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 635
++ A L + G +DE + ++++ E++ ++ KE E
Sbjct: 5198 EFKAADVEQLKPEEIKSGTTAPLG--FDEMEVEI-QTVKTEEDQDPRTDKAHKETENEKP 5254
Query: 636 EYKKE------------------IEELKELLPEIREKIEDAKESQRSGNVAELALKATLV 677
E +E ++++ EL E+ ++E + + SGN E + A +
Sbjct: 5255 ERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQLE-MWQPRESGNPEEEKVAAEMW 5313
Query: 678 ES 679
+S
Sbjct: 5314 QS 5315
Score = 60.5 bits (145), Expect = 6e-09
Identities = 84/387 (21%), Positives = 156/387 (40%), Gaps = 55/387 (14%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNID--EEAREELREQVYDAMGEKEEAKKTEDKSLAKP 170
E + + ++ +ED++ E+ DN + EE E++E+ +A E EE +TE
Sbjct: 4877 EALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETD----- 4931
Query: 171 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 230
+ + + E E+G ED E +E++D T + + G A + P E
Sbjct: 4932 QNESQSPQEPEEGPSED-----DKAEGEEEMD--------TGADDQDGDAAQHPEE---H 4975
Query: 231 SGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 290
S + +Q V + ++E G + G QG EE+ +EEQ LE+
Sbjct: 4976 SEEQQQSVEEKDKEADEEGGE--------NGPADQGFQPQEEEEREDSDTEEQVPEALER 5027
Query: 291 Q--GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 348
+ + + E++ T + +++ G PE++ E+ +G A Q G ES
Sbjct: 5028 KEHASCGQTGVENMQNT-QAMELAGAAPEKEQGKEEHGSGAADANQAEG------HESNF 5080
Query: 349 VTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD 408
+ A++ + KPGQ + +GD + + T D
Sbjct: 5081 IAQLASQKHTRKNTQSFKRKPGQ----------ADNERSMGDH-----NERVHKRLRTVD 5125
Query: 409 GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQE 468
E+ A+ +Q E + E + D D + A+++ + ++E +E
Sbjct: 5126 TDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEE 5185
Query: 469 REEQMKEGEETEGSEEDDKENDKTEEM 495
E+ + + EE E + D E K EE+
Sbjct: 5186 IEDTLMDTEEQEEFKAADVEQLKPEEI 5212
Score = 34.3 bits (77), Expect = 0.46
Identities = 75/386 (19%), Positives = 145/386 (37%), Gaps = 52/386 (13%)
Query: 408 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ 467
+G G+ E K V Q + VE++ G D + ++ ED A E ++
Sbjct: 4676 EGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDN----AIEMSE 4731
Query: 468 EREEQMKEGEETEGSEEDDKE--------------NDKTEEMPNDSVLENKSLQENEEEE 513
+ + +M +GE E E+D+K N + + ++ + + +E+EEEE
Sbjct: 4732 DFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEE 4791
Query: 514 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 573
E +D ++++L A +L G + + + E+ ++ +
Sbjct: 4792 DNKTEETGPGMD----------EEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADD 4841
Query: 574 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 633
Q + + + E Y Y+ ++ +++++ ++ LN ++ G
Sbjct: 4842 GGQGEDKINEQIDERDYDENEVDPYHGNQEKVPE--PEALDLPDD----LNLDSEDKNGG 4895
Query: 634 SAEYKKEIEELKELLPEIREKIEDA-KESQRSGNVAELALKATLVESSTSGFTPGGGGSS 692
+E EE L EI+EK E+A E++ G T S S P G S
Sbjct: 4896 EDTDNEEGEEENPL--EIKEKPEEAGHEAEERGET------ETDQNESQSPQEPEEGPSE 4947
Query: 693 VSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDA--KKAKQEPEVNGGSGDA 750
+ D + H PEE S + + +K K+ E G +G A
Sbjct: 4948 DDKAEGEEEMDTGADDQDGDAAQH-------PEEHSEEQQQSVEEKDKEADEEGGENGPA 5000
Query: 751 VPSGNEVSENMEEEAENQAESRAAVE 776
E E+++ + + A+E
Sbjct: 5001 DQGFQPQEEEEREDSDTEEQVPEALE 5026
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%)
Query: 156 KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 215
KE+ + DK L + E +E+ + K +++ S+ + +E + TS +
Sbjct: 1080 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1138
Query: 216 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 275
K E + TS K +Q + S S +D++++ + G+ S E+K
Sbjct: 1139 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1187
Query: 276 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 335
K V+E +V G E+L +V PV V D+ + EN K +L +
Sbjct: 1188 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1241
Query: 336 VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 395
+ + E+ + + E G + E PG E + + S +
Sbjct: 1242 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1299
Query: 396 PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 449
+ +LT + SG E+K + K V + K+S E+SE + GV +V++
Sbjct: 1300 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1359
Query: 450 TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 505
E+ P K ++ N+ + +++++ + + E S ++K N + EE + E +
Sbjct: 1360 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419
Query: 506 LQENEEEE 513
+E EEE+
Sbjct: 1420 EEEEEEED 1427
Score = 42.4 bits (98), Expect = 0.002
Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%)
Query: 147 EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 206
++V D + + E +D+S E DK+Q + + ++ D K + +++ + + D
Sbjct: 917 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 976
Query: 207 WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 250
+ E + P+G + + T G K + E+ D E+ + G
Sbjct: 977 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1036
Query: 251 DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 306
D E+ + K G ++K+ +++ K ++ S ++ + E S D +
Sbjct: 1037 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1091
Query: 307 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 365
K +++ E + ++S+ + E G AEES E + + S+ + V
Sbjct: 1092 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1143
Query: 366 SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 422
EK K + S + Q SI +GS E+K++ LV
Sbjct: 1144 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1197
Query: 423 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 475
S EA V V + PE+++ +I AN + E+ +
Sbjct: 1198 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1255
Query: 476 GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 534
E EG + K+N EE P D +N+ E++ + + + + L K+
Sbjct: 1256 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1312
Query: 535 ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 591
E+ E + + H ++ V SE+ + +FQ + E+ E+ D T
Sbjct: 1313 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1366
Query: 592 LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 647
+ +K E+ EN+ + + ++K E SS+E K EE +E
Sbjct: 1367 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1410
Query: 648 LPEIREKIEDAKESQRSGN 666
E E+ E+ +E + N
Sbjct: 1411 KEEEEEEEEEEEEEEEDEN 1429
Score = 38.9 bits (89), Expect = 0.019
Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%)
Query: 177 DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 234
D + K +D +P+ ++ + L+ + + G++ + P E + +GK
Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268
Query: 235 EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 290
+E P EE K S S +D +E + + + + + E + +P E
Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1328
Query: 291 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 350
+G + V+SE+ E V +EV +E+
Sbjct: 1329 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365
Query: 351 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 410
T +A+ + +E ++ + + ++ + +E K S
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1404
Query: 411 GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 465
EE+ + +EE + EE E D D + G K +DK++
Sbjct: 1405 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1458
Query: 466 TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 512
+E EE+ K E E E +E + E+ P + K + + +EE
Sbjct: 1459 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1506
Score = 34.3 bits (77), Expect = 0.46
Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 110 NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 169
N+ E +EEE E+ E+E E ++N D ++ + R+++ + K++ +TE ++ K
Sbjct: 1403 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1460
Query: 170 PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
E + +++ +E E+ + ++ + + K +T + + EE K
Sbjct: 1461 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1508
Score = 31.6 bits (70), Expect = 3.0
Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%)
Query: 155 EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 208
+K ++ K+ S K +T E DSE+EK E +SK +A ++++ T D+
Sbjct: 755 KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 811
Query: 209 TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 268
+E + +K G +G + + + +E ++ S + G +K +
Sbjct: 812 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 863
Query: 269 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 328
+ + PK+ ++K + E SL+ V+ V E +EK + +
Sbjct: 864 MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 916
Query: 329 KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 381
K V + L + ++ ++S E + + + S + G+E +KP + K + +
Sbjct: 917 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 974
Query: 382 VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 439
+G + ++ I P+ + T DG +K+R K ++E E+S GD
Sbjct: 975 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1034
Query: 440 GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 495
D+ K GA + +K + ++ + + + + S ++D N + +
Sbjct: 1035 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1091
Query: 496 PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 544
+ E ++L + +EI + + D + ++ K+++ KE + +
Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1151
Query: 545 QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 600
+ K + + S + ++ Q+ + + EQ ++ + L+ +H + G
Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1208
Query: 601 QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 639
DEA+ SKS+ V ENR+A +L E++K + +GSS E KK
Sbjct: 1209 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1263
Query: 640 EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 688
+ E P E + ++ D++ES++ L V SG T
Sbjct: 1264 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1323
Query: 689 GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 741
V RK + S + + +E+ PR AKKA+ E
Sbjct: 1324 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1383
Query: 742 -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 776
+V S S +E E +EE E + E E
Sbjct: 1384 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425
Score = 31.6 bits (70), Expect = 3.0
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Query: 124 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 182
K +++S EN N +EE E+ E+ + E+EE + +D KS K + + +K
Sbjct: 1391 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450
Query: 183 GGREDMDISKSAEEPQEKV 201
E + K EE ++++
Sbjct: 1451 LRTETQNALKEEEERRKRI 1469
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%)
Query: 156 KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 215
KE+ + DK L + E +E+ + K +++ S+ + +E + TS +
Sbjct: 1118 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1176
Query: 216 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 275
K E + TS K +Q + S S +D++++ + G+ S E+K
Sbjct: 1177 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1225
Query: 276 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 335
K V+E +V G E+L +V PV V D+ + EN K +L +
Sbjct: 1226 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1279
Query: 336 VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 395
+ + E+ + + E G + E PG E + + S +
Sbjct: 1280 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1337
Query: 396 PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 449
+ +LT + SG E+K + K V + K+S E+SE + GV +V++
Sbjct: 1338 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1397
Query: 450 TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 505
E+ P K ++ N+ + +++++ + + E S ++K N + EE + E +
Sbjct: 1398 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457
Query: 506 LQENEEEE 513
+E EEE+
Sbjct: 1458 EEEEEEED 1465
Score = 42.4 bits (98), Expect = 0.002
Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%)
Query: 147 EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 206
++V D + + E +D+S E DK+Q + + ++ D K + +++ + + D
Sbjct: 955 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 1014
Query: 207 WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 250
+ E + P+G + + T G K + E+ D E+ + G
Sbjct: 1015 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1074
Query: 251 DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 306
D E+ + K G ++K+ +++ K ++ S ++ + E S D +
Sbjct: 1075 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1129
Query: 307 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 365
K +++ E + ++S+ + E G AEES E + + S+ + V
Sbjct: 1130 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1181
Query: 366 SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 422
EK K + S + Q SI +GS E+K++ LV
Sbjct: 1182 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1235
Query: 423 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 475
S EA V V + PE+++ +I AN + E+ +
Sbjct: 1236 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1293
Query: 476 GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 534
E EG + K+N EE P D +N+ E++ + + + + L K+
Sbjct: 1294 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1350
Query: 535 ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 591
E+ E + + H ++ V SE+ + +FQ + E+ E+ D T
Sbjct: 1351 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1404
Query: 592 LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 647
+ +K E+ EN+ + + ++K E SS+E K EE +E
Sbjct: 1405 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1448
Query: 648 LPEIREKIEDAKESQRSGN 666
E E+ E+ +E + N
Sbjct: 1449 KEEEEEEEEEEEEEEEDEN 1467
Score = 38.9 bits (89), Expect = 0.019
Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%)
Query: 177 DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 234
D + K +D +P+ ++ + L+ + + G++ + P E + +GK
Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1306
Query: 235 EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 290
+E P EE K S S +D +E + + + + + E + +P E
Sbjct: 1307 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1366
Query: 291 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 350
+G + V+SE+ E V +EV +E+
Sbjct: 1367 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403
Query: 351 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 410
T +A+ + +E ++ + + ++ + +E K S
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1442
Query: 411 GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 465
EE+ + +EE + EE E D D + G K +DK++
Sbjct: 1443 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1496
Query: 466 TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 512
+E EE+ K E E E +E + E+ P + K + + +EE
Sbjct: 1497 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1544
Score = 34.3 bits (77), Expect = 0.46
Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 110 NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 169
N+ E +EEE E+ E+E E ++N D ++ + R+++ + K++ +TE ++ K
Sbjct: 1441 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1498
Query: 170 PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
E + +++ +E E+ + ++ + + K +T + + EE K
Sbjct: 1499 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1546
Score = 31.6 bits (70), Expect = 3.0
Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%)
Query: 155 EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 208
+K ++ K+ S K +T E DSE+EK E +SK +A ++++ T D+
Sbjct: 793 KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 849
Query: 209 TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 268
+E + +K G +G + + + +E ++ S + G +K +
Sbjct: 850 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 901
Query: 269 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 328
+ + PK+ ++K + E SL+ V+ V E +EK + +
Sbjct: 902 MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 954
Query: 329 KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 381
K V + L + ++ ++S E + + + S + G+E +KP + K + +
Sbjct: 955 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 1012
Query: 382 VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 439
+G + ++ I P+ + T DG +K+R K ++E E+S GD
Sbjct: 1013 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1072
Query: 440 GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 495
D+ K GA + +K + ++ + + + + S ++D N + +
Sbjct: 1073 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1129
Query: 496 PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 544
+ E ++L + +EI + + D + ++ K+++ KE + +
Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1189
Query: 545 QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 600
+ K + + S + ++ Q+ + + EQ ++ + L+ +H + G
Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1246
Query: 601 QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 639
DEA+ SKS+ V ENR+A +L E++K + +GSS E KK
Sbjct: 1247 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1301
Query: 640 EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 688
+ E P E + ++ D++ES++ L V SG T
Sbjct: 1302 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1361
Query: 689 GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 741
V RK + S + + +E+ PR AKKA+ E
Sbjct: 1362 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1421
Query: 742 -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 776
+V S S +E E +EE E + E E
Sbjct: 1422 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463
Score = 31.6 bits (70), Expect = 3.0
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Query: 124 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 182
K +++S EN N +EE E+ E+ + E+EE + +D KS K + + +K
Sbjct: 1429 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488
Query: 183 GGREDMDISKSAEEPQEKV 201
E + K EE ++++
Sbjct: 1489 LRTETQNALKEEEERRKRI 1507
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/296 (22%), Positives = 116/296 (39%), Gaps = 10/296 (3%)
Query: 118 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---KPETDK 174
E + + D+ + + ++DEE E RE+ D E K + K + +P
Sbjct: 968 EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL 1027
Query: 175 EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 234
E DS E+ +E + + + E +E+ + + + +++ E +E S
Sbjct: 1028 ELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEAS 1087
Query: 235 EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 294
E++ D++EE++VS + E + E S E P +E+ VV E++
Sbjct: 1088 EKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEE 1147
Query: 295 VEVE--AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG--QEVPPAEESPEVT 350
E E AE + P D D E + +E+ V E EE P +
Sbjct: 1148 EEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSML 1207
Query: 351 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTE 405
E VE ++ E P E P L ++GA + P + P S ER E
Sbjct: 1208 DEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPE 1261
Score = 54.3 bits (129), Expect = 4e-07
Identities = 79/294 (26%), Positives = 120/294 (40%), Gaps = 42/294 (14%)
Query: 122 GEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD---- 177
GE+ E ESL E ++ +EE EE E E+EE +D S + E++ + +
Sbjct: 1033 GEEDEKESLSEEQESTEEE--EEAEE-------EEEEEDDDDDDSDDRDESENDDEDTAL 1083
Query: 178 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 237
SE + D D ++ K + T +S E+ + E +E+ +S + E+E
Sbjct: 1084 SEASEKDEGDSDEEETVSIVTSKAEAT------SSSESSESSEFESSSESSPSSSEDEEE 1137
Query: 238 VPDAEEEKSVSGTD-VQEECREKGGQ---EKQGEVIVSIEEKPKEVS---EEQPVVTLEK 290
V EEE+ + V EE G E+ GE P S EE+ V +E
Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEE--VDIET 1195
Query: 291 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 350
+ A E LD P+ VG +EP + E E G + ++ PPA+E E
Sbjct: 1196 EAVAPEERPSMLDE--PPLPVGVEEPADSREPPE-EPGLSQEGAMLLSPEPPAKE-VEAR 1251
Query: 351 TEAAEASAVEAGSEVSEKPGQEAPV-----LPKDGAVNGPSVVGDQTPIEPQTS 399
+ A E EV +P P+ LP PS P EP+T+
Sbjct: 1252 PPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPS-----PPPEPETT 1300
Score = 53.5 bits (127), Expect = 7e-07
Identities = 75/333 (22%), Positives = 121/333 (36%), Gaps = 45/333 (13%)
Query: 104 ENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE 163
E L E EEE E+ E+E +++ + +E+ + + EK+E E
Sbjct: 1037 EKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDE 1096
Query: 164 DKSL----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEE--AKG 217
++++ +K E +S + S S+ E +E+V + E EE A+
Sbjct: 1097 EETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEE 1156
Query: 218 GAAPEGP-------NEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR------------- 257
A GP EA + G P + EEE + V E R
Sbjct: 1157 SMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGV 1216
Query: 258 ----------EKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVK 307
E+ G ++G +++S E KEV P+ +EVE E P +
Sbjct: 1217 EEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPE--PPMML 1274
Query: 308 PVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP---AEESPEVTTEAAEASAVEAGSE 364
P+ + P + + + VPP AE+ P T + A +E
Sbjct: 1275 PLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTE 1334
Query: 365 -VSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEP 396
V PG E P+ G +G S+ Q P P
Sbjct: 1335 TVPATPGGEPPL---SGGSSGLSLSSPQVPGSP 1364
Score = 50.1 bits (118), Expect = 8e-06
Identities = 47/202 (23%), Positives = 93/202 (46%), Gaps = 25/202 (12%)
Query: 389 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQG 448
GDQ + P TS++ E + E+ R +T + + + G GV + A+
Sbjct: 976 GDQKRLRPSTSVDEEDEESE----RERDR-----DMADTPCELAKRDPKGVGVRRRPARP 1026
Query: 449 ATEKS---PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 505
S ++K ++ +E+ E EE+ +E EE E ++DD ++D +E ND E+ +
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEE--DDDDDDSDDRDESENDD--EDTA 1082
Query: 506 LQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVE 565
L E E++ G+ D + I+ T +A+ ++ + E SE+ + E
Sbjct: 1083 LSEASEKDEGDS----DEEETVSIV-----TSKAEATSSSESSESSEFESSSESSPSSSE 1133
Query: 566 EFQSCLNLQEQYLEAHDRLLAE 587
+ + + +E+ E + ++AE
Sbjct: 1134 DEEEVVAREEEEEEEEEEMVAE 1155
Score = 45.1 bits (105), Expect = 3e-04
Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 54/263 (20%)
Query: 261 GQEKQGEVIVSIEEKPKEVSEEQ-------PVVTLEKQGTAVEVEAESLDPTVKPVDVGG 313
G +K+ S++E+ +E E+ P ++ V V P +D GG
Sbjct: 976 GDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL--ELDSGG 1033
Query: 314 DEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEA 373
+E E++ ++ E E+ TE E EA E E+ +
Sbjct: 1034 EEDEKESLSEEQES-----------------------TEEEE----EAEEEEEEEDDDDD 1066
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE 433
+D + N + T++ +E +G EE+ +V S+ E S E
Sbjct: 1067 DSDDRDESEND----------DEDTALSEASEKDEGDSDEEET-VSIVTSKAEATSSSES 1115
Query: 434 SEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE---TEGSEEDDKEND 490
SE++ + + + ++ S ED+ ++ A EE +E EE+ EE + G E+ +++ +
Sbjct: 1116 SESS----EFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGE 1171
Query: 491 KTEEMPNDSVLENKSLQENEEEE 513
+ P +++ ++E + E
Sbjct: 1172 EAALAPGAPAVDSLGMEEEVDIE 1194
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 64.3 bits (155), Expect = 4e-10
Identities = 112/543 (20%), Positives = 225/543 (41%), Gaps = 76/543 (13%)
Query: 137 IDEEAREELREQVYD-AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAE 195
++ + EELR++ M E K+ +D K + D++ + E+ G D+S
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG----DLSFKLR 328
Query: 196 EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEE 255
E + D L E +EE ++ T E++ A+ EK +S ++
Sbjct: 329 EFASHLQQLQDALNELTEE-----------HSKATQEWLEKQ---AQLEKELSAALQDKK 374
Query: 256 CREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDE 315
C E+ + QG+ + +EE ++ + P E G +++E +L + +
Sbjct: 375 CLEEKNEILQGK-LSQLEEHLSQLQDNPPQEKGEVLGDVLQLE--TLKQEAATLAANNTQ 431
Query: 316 PEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA-SAVEAGSEVSEKPGQEAP 374
+ +V E E G+ + L+ + EE ++++ + S++ S+ E+ Q +
Sbjct: 432 LQARVEMLETERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ 490
Query: 375 VLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES 434
S+ + T + +I++ + ++ +GL+++ + K Q + ++++
Sbjct: 491 AHGARLTAQVASLTSELTTLN--ATIQQ--QDQELAGLKQQAKEK----QAQLAQTLQQQ 542
Query: 435 EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKE-GEETEGSEEDDKENDKTE 493
E A G+ +V Q + +++E+Q+KE E+ E + +D + T
Sbjct: 543 EQASQGLRHQVEQ--------------LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 494 EMPNDSVLEN-----KSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHL 548
++ L K L+ E+E+ LE+ L +A + AQ QA
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-----EARDSAQTSVTQAQR 643
Query: 549 KLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQ 608
+ E+S + VEE Q+C+ Q +AE QL + + E VAQ
Sbjct: 644 EKAELS-------RKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQ 695
Query: 609 FSKSIEVIENRMAVLNEQVKEAEGSSAEYKKE----IEE----LKELLPEIREKIEDAKE 660
+ ++ ++ L E +K +GS E K+ +EE + EL E R +E K
Sbjct: 696 ---EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752
Query: 661 SQR 663
++
Sbjct: 753 ERK 755
Score = 60.1 bits (144), Expect = 8e-09
Identities = 126/636 (19%), Positives = 243/636 (38%), Gaps = 109/636 (17%)
Query: 115 VHVEEEEGEKTEDESLVENNDNIDEEAR-------------EELREQVYDAMGEKEEA-- 159
+ + E+ + TE E + + D + E+ + EE + + DA+ E++
Sbjct: 678 LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737
Query: 160 -KKTEDKSLAKPETDKEQDSEMEKGGREDMD--ISKSAEEPQEKVDLTLDWLTET----- 211
K E +SL + + ++ E E+ GR+ ++ + + E Q + ++ L E
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 212 ------------------------SEEAKGGAA-PEGPNEAEVTSGKPEQEVPDAEEEKS 246
EEA+ GA E + K QE+ +A+E+
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-- 855
Query: 247 VSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 306
V+G + E + Q + E+ ++ ++V E++ V +K + E + T
Sbjct: 856 VAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLSTLQEKMAATS 913
Query: 307 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE------AAEASAVE 360
K V E +V E + +LV + + PE E + +A++
Sbjct: 914 KEV-----ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968
Query: 361 AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS----GLEEKV 416
A +E+ G E L A+ + + + + RLT+ + + LE+
Sbjct: 969 AMEREAEQMGNELERLR--AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026
Query: 417 RAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK----------VQIAANEET 466
RA+L + + ++ E + +A TEK +D+ QI EE
Sbjct: 1027 RAEL---EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083
Query: 467 QEREEQMKEG------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 520
++ +Q+KE E GS + +TE P LE + ++ E+ +
Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE--PTGPKLEALRAEVSKLEQ--QCQKQ 1139
Query: 521 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEA 580
+ D + + + A+ +A L + + E Q + QS L ++ L A
Sbjct: 1140 QEQADSLERSLEAERASRAERDSA-----LETLQGQLEEKAQELGHSQSALASAQRELAA 1194
Query: 581 -----HDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 635
D AE ++ +A G + + + I +E +++LN QV E EG S
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGR-----QEAERKNSLISSLEEEVSILNRQVLEKEGESK 1249
Query: 636 EYKKEIEELKELLPEIREKIE--DAKESQRSGNVAE 669
E K+ + E ++ E++ A+ + S AE
Sbjct: 1250 ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Score = 37.7 bits (86), Expect = 0.042
Identities = 119/692 (17%), Positives = 264/692 (38%), Gaps = 92/692 (13%)
Query: 117 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET-DKE 175
VE+ + E ++ E R++ +Q+ A E+E + + D +L + E +KE
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 176 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSG 232
+ +++E ++ +++ + Q V E S EE + + E +
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 233 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI---VSIEEKPKEVSEEQPVVTLE 289
E E+ E++ T+ + +EK ++Q + + + + + E + + LE
Sbjct: 673 VAELELQLRSEQQ--KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
Query: 290 KQGTAV-EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 348
+Q + E++AE+ + E+ E AG+ LE + Q + E
Sbjct: 731 EQQRCISELKAETR-------SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 349 V-TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI--ERLTE 405
V E AEA A + +E E L K+ A Q ++ E+L
Sbjct: 784 VLRRELAEAMAAQHTAE------SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837
Query: 406 TKDGSGLEEKVRAKL---------VPSQEETKLSVEESEAAGDGVD-TKVAQGATEKSPE 455
K+ EK R +L + S E ++S +++E A + + Q EK E
Sbjct: 838 LKEEC---EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK--E 892
Query: 456 DKVQIAANEETQEREEQMKEGEET---------EGSEEDDKENDKTEEMPNDSVLENKSL 506
+ Q A++ + +E+ +E G +++ + +E + + L
Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 507 QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 566
+E + + + + A + E + Q+ L+ + + + + ++
Sbjct: 953 EEQQGRQFCSTQAA----------LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002
Query: 567 FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV---L 623
+ L ++ A L E + L + +E +F+ E + + +
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062
Query: 624 NEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSG 683
++++ + G A KE+EEL++ + +++E++ ++ SG+ A+
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ-------------- 1108
Query: 684 FTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEV 743
S A R G ++S L ++ +K +E++ + + +A++
Sbjct: 1109 ----------SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158
Query: 744 NGGSGDAVPSGNEVSENMEEEAENQAESRAAV 775
S G +EE+A+ S++A+
Sbjct: 1159 ERDSALETLQG-----QLEEKAQELGHSQSAL 1185
Score = 31.2 bits (69), Expect = 3.9
Identities = 86/445 (19%), Positives = 171/445 (38%), Gaps = 65/445 (14%)
Query: 67 AFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGV---HVEEEEGE 123
++ E S+L K +G A E + L E A + L L+ +V+E
Sbjct: 1432 SYAEQLSMLKKAHGLLAEE--------NRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
Query: 124 KTEDESLVENNDNIDEEAREELRE-QVYDAMGEKEEAKKTEDKSLAKPETDK-------- 174
+ + E+ + + EA+ RE +V A E + K E++ + E K
Sbjct: 1484 RADAETRLAE---VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540
Query: 175 -----EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEV 229
EQ ++E+ ++ D ++++ Q+K+ E+ +EA+ A +A++
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 230 TSGKPEQEVPDAEEEKSVSGTD--------VQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
+ + E + EK+ + D +QE+ R +K+ + + + E+ +
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ 1660
Query: 282 EQPVVTLEKQGTAVEVEAE--SLDPTVKPV-----DVGGDEPEEKVVTSENEAGKAVLEQ 334
+ + T E + T + A+ SL+ V D+G + + S K L+
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDL 1720
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKP----GQEAPVLPKDGAVNG----PS 386
+ EE ++ + G+ V +P Q P PK ++ P
Sbjct: 1721 SIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLP--PKVESLESLYFTPI 1778
Query: 387 VVGDQTPIEPQTSIERLTETKDGSGLE----EKVRAKLVPSQEETKLSVEESEAAGDGVD 442
Q P+E +S++ L + SG + + +++ KL VEE ++A
Sbjct: 1779 PARSQAPLE--SSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSF- 1835
Query: 443 TKVAQGATEKSPEDKVQIAANEETQ 467
+T +P + + A TQ
Sbjct: 1836 -----YSTRSAPASQASLRATSSTQ 1855
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 63.5 bits (153), Expect = 7e-10
Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 168
EEE E +E+ S E ++ + E++ AK T K
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 169 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 219
KPE D E SE E+ +K+ + + K E + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 220 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 274
AP GP A+ +GK E++ + EE S S + + + G + +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 275 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 334
P++ + P K G P V VG E + + + E+++ + L
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 394
+ +V P +SP+V + PG+ P PS +
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543
Query: 395 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 454
+ ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
VQ+ A E+ + E +E ++ SEE + P + + K+ +
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 574
AK+ R T +A A A G + + E+ S +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 629
E E LA T Q + G Q A S+ V+ + QVK
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756
Query: 630 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 689
+ +E +E + +E + K++Q N A A +A + + S PG
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812
Query: 690 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 749
++ + R P+ + + L R A +A+ PE + GS
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870
Query: 750 AVPSGNEVSENMEEEAENQAE 770
+E + EEEAE A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)
Query: 142 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 187
R EL +Y + G A++ +++S LA+P T +Q SE+ + + +
Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66
Query: 188 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 247
D + A++ + ++ +E EEA+ A P A S ++P + +EK+
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126
Query: 248 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 292
+ T+ + G+ + ++ + P++ +E TL E++G
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 293 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 328
+A + ++ S D P+VKP V + P K + + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246
Query: 329 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 373
V Q+ G +PPA EE E + E +E+ S V+A ++ + A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 431
P G P+ G + QT + E + S E S+EET ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359
Query: 432 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 491
+++A+G A ++SP A +T + + G+ E S+ +E+D
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 492 TEEMPNDSVLENKSLQ 507
EE P + K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
T + K E D E SE E D ++ + QEK + TS AKG
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 222 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
GP +V + KP + ++ EE + E+ + + + KP +
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638
Query: 282 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 341
Q +K T + V PV VG P K T+ + AG + + G
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688
Query: 342 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 392
PAE+S +E AV G S G + PV G P + G
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
Query: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452
P Q E+ +++ + A P+Q K SV++++A + +
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806
Query: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 512
S KV AA + Q ++K + + +V Q EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866
Query: 513 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 549
+ G+ E D + A+ + + + K Q+ AA A K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/341 (22%), Positives = 122/341 (35%), Gaps = 61/341 (17%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
+ED S + ETD E ++ + +S + E P K + + + + KGGA P
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 222 EGPNEAEVTSGKPEQEVPDAEE-----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+ KPE+E +EE E++ +GT Q + EK Q + + P
Sbjct: 259 PAKR-----AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA--PAKGTP 311
Query: 277 KEVSEEQP---VVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333
+ + P + Q A + E +S + + D + P K + +GK
Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT--- 368
Query: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393
VG PA+ESP A PG+ P + K A G Q+
Sbjct: 369 SQVGAASAPAKESPRKGAAPAP-------------PGKTGPAVAKAQA--GKREEDSQSS 413
Query: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
E S E SG +VRA P++E + +GA
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR------------------KGAAPAP 455
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
P AA Q++ G++ E S +E+D E
Sbjct: 456 PRKTGPAAA---------QVQVGKQEEDSRSSSEESDSDRE 487
Score = 34.3 bits (77), Expect = 0.46
Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)
Query: 368 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 427
K ++A + K V+ P + + E + E T + V +PS +
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123
Query: 428 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 468
K E +A G VA + KSP + +AN ET+E
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
Query: 469 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 523
+ + G+ SE+ +D+T E P+ + K+ + +E
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242
Query: 524 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 583
K+ + K L A+ K E S SE ++ EE + Q ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296
Query: 584 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 643
+L + A G + + + E + + S++ ++E
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 644 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 700
K LL AK S ++ V A A ES G P G G +V+ + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405
Query: 701 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 750
+ + SS+ +D + KP ++P+ K+ +K A P G +
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 751 VPSG--NEVSENMEEEAENQAESRAAV 775
V G E S + EE+++ E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492
Score = 32.0 bits (71), Expect = 2.3
Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)
Query: 626 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 685
QVK A+ K+ EE E E E E+A RS A + S+ + T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 686 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 723
PG G G+ S + KP + + SS+ + S L++ K
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 724 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 772
P +ESPRK A P G +G AV E S++ EE++++ E+
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 773 AAVEGTVEA 781
A + + +A
Sbjct: 425 AQAKPSGKA 433
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)
Query: 154 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 209
GE EA +KT S K + DK EK G+ + + +EP+E++
Sbjct: 1333 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1385
Query: 210 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 269
KG EG +++ S K +++ +++K +++ + K K E
Sbjct: 1386 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1435
Query: 270 VSIEEKPKEVSEEQPV 285
++K K+ + EQ V
Sbjct: 1436 SQKKKKKKKKTAEQTV 1451
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 63.5 bits (153), Expect = 7e-10
Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 168
EEE E +E+ S E ++ + E++ AK T K
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 169 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 219
KPE D E SE E+ +K+ + + K E + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 220 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 274
AP GP A+ +GK E++ + EE S S + + + G + +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 275 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 334
P++ + P K G P V VG E + + + E+++ + L
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 394
+ +V P +SP+V + PG+ P PS +
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543
Query: 395 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 454
+ ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
VQ+ A E+ + E +E ++ SEE + P + + K+ +
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 574
AK+ R T +A A A G + + E+ S +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 629
E E LA T Q + G Q A S+ V+ + QVK
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756
Query: 630 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 689
+ +E +E + +E + K++Q N A A +A + + S PG
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812
Query: 690 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 749
++ + R P+ + + L R A +A+ PE + GS
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870
Query: 750 AVPSGNEVSENMEEEAENQAE 770
+E + EEEAE A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)
Query: 142 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 187
R EL +Y + G A++ +++S LA+P T +Q SE+ + + +
Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66
Query: 188 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 247
D + A++ + ++ +E EEA+ A P A S ++P + +EK+
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126
Query: 248 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 292
+ T+ + G+ + ++ + P++ +E TL E++G
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 293 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 328
+A + ++ S D P+VKP V + P K + + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246
Query: 329 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 373
V Q+ G +PPA EE E + E +E+ S V+A ++ + A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 431
P G P+ G + QT + E + S E S+EET ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359
Query: 432 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 491
+++A+G A ++SP A +T + + G+ E S+ +E+D
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 492 TEEMPNDSVLENKSLQ 507
EE P + K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
T + K E D E SE E D ++ + QEK + TS AKG
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 222 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
GP +V + KP + ++ EE + E+ + + + KP +
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638
Query: 282 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 341
Q +K T + V PV VG P K T+ + AG + + G
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688
Query: 342 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 392
PAE+S +E AV G S G + PV G P + G
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
Query: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452
P Q E+ +++ + A P+Q K SV++++A + +
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806
Query: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 512
S KV AA + Q ++K + + +V Q EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866
Query: 513 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 549
+ G+ E D + A+ + + + K Q+ AA A K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/341 (22%), Positives = 122/341 (35%), Gaps = 61/341 (17%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
+ED S + ETD E ++ + +S + E P K + + + + KGGA P
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 222 EGPNEAEVTSGKPEQEVPDAEE-----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+ KPE+E +EE E++ +GT Q + EK Q + + P
Sbjct: 259 PAKR-----AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA--PAKGTP 311
Query: 277 KEVSEEQP---VVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333
+ + P + Q A + E +S + + D + P K + +GK
Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT--- 368
Query: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393
VG PA+ESP A PG+ P + K A G Q+
Sbjct: 369 SQVGAASAPAKESPRKGAAPAP-------------PGKTGPAVAKAQA--GKREEDSQSS 413
Query: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
E S E SG +VRA P++E + +GA
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR------------------KGAAPAP 455
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
P AA Q++ G++ E S +E+D E
Sbjct: 456 PRKTGPAAA---------QVQVGKQEEDSRSSSEESDSDRE 487
Score = 34.3 bits (77), Expect = 0.46
Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)
Query: 368 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 427
K ++A + K V+ P + + E + E T + V +PS +
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123
Query: 428 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 468
K E +A G VA + KSP + +AN ET+E
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
Query: 469 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 523
+ + G+ SE+ +D+T E P+ + K+ + +E
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242
Query: 524 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 583
K+ + K L A+ K E S SE ++ EE + Q ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296
Query: 584 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 643
+L + A G + + + E + + S++ ++E
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 644 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 700
K LL AK S ++ V A A ES G P G G +V+ + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405
Query: 701 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 750
+ + SS+ +D + KP ++P+ K+ +K A P G +
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 751 VPSG--NEVSENMEEEAENQAESRAAV 775
V G E S + EE+++ E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492
Score = 32.0 bits (71), Expect = 2.3
Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)
Query: 626 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 685
QVK A+ K+ EE E E E E+A RS A + S+ + T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 686 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 723
PG G G+ S + KP + + SS+ + S L++ K
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 724 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 772
P +ESPRK A P G +G AV E S++ EE++++ E+
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 773 AAVEGTVEA 781
A + + +A
Sbjct: 425 AQAKPSGKA 433
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)
Query: 154 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 209
GE EA +KT S K + DK EK G+ + + +EP+E++
Sbjct: 1370 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1422
Query: 210 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 269
KG EG +++ S K +++ +++K +++ + K K E
Sbjct: 1423 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1472
Query: 270 VSIEEKPKEVSEEQPV 285
++K K+ + EQ V
Sbjct: 1473 SQKKKKKKKKTAEQTV 1488
Score = 30.4 bits (67), Expect = 6.7
Identities = 73/334 (21%), Positives = 122/334 (36%), Gaps = 47/334 (14%)
Query: 158 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG 217
+A T K+ A T + SE E ED+ + P + ++ T A
Sbjct: 979 QAASTPRKARASESTARSSSSESED---EDVIPATQCLTPGIRTNVV------TMPTAHP 1029
Query: 218 GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK 277
AP+ + A +S K + D ++++ G Q + + + +K
Sbjct: 1030 RIAPKA-SMAGASSSKESSRISDGKKQE---GPATQVSKKNPASLPLTQAALKVLAQK-- 1083
Query: 278 EVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG 337
SE QP V + + V+ +L T P+ TS G L +
Sbjct: 1084 -ASEAQPPVARTQPSSGVDSAVGTLPAT---------SPQS---TSVQAKGTNKLRKPKL 1130
Query: 338 QEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 397
EV A ++PE + ++ ++S +GSE E P K GP+ +T +E
Sbjct: 1131 PEVQQATKAPESSDDSEDSSDSSSGSE----EDGEGPQGAKSAHTLGPTPSRTETLVEET 1186
Query: 398 T--SIERLTETKDGSGLEEKVRAKLVPSQE---------ETKLSVEESEAAGDGVD---- 442
S E S L + L P+ ++ SV + AA D D
Sbjct: 1187 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1246
Query: 443 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 476
K Q A SP+ + AA+ T ++ + K+G
Sbjct: 1247 AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 63.5 bits (153), Expect = 7e-10
Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 168
EEE E +E+ S E ++ + E++ AK T K
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 169 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 219
KPE D E SE E+ +K+ + + K E + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 220 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 274
AP GP A+ +GK E++ + EE S S + + + G + +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 275 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 334
P++ + P K G P V VG E + + + E+++ + L
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 394
+ +V P +SP+V + PG+ P PS +
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543
Query: 395 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 454
+ ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
VQ+ A E+ + E +E ++ SEE + P + + K+ +
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 574
AK+ R T +A A A G + + E+ S +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 629
E E LA T Q + G Q A S+ V+ + QVK
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756
Query: 630 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 689
+ +E +E + +E + K++Q N A A +A + + S PG
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812
Query: 690 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 749
++ + R P+ + + L R A +A+ PE + GS
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870
Query: 750 AVPSGNEVSENMEEEAENQAE 770
+E + EEEAE A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)
Query: 142 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 187
R EL +Y + G A++ +++S LA+P T +Q SE+ + + +
Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66
Query: 188 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 247
D + A++ + ++ +E EEA+ A P A S ++P + +EK+
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126
Query: 248 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 292
+ T+ + G+ + ++ + P++ +E TL E++G
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 293 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 328
+A + ++ S D P+VKP V + P K + + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246
Query: 329 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 373
V Q+ G +PPA EE E + E +E+ S V+A ++ + A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 431
P G P+ G + QT + E + S E S+EET ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359
Query: 432 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 491
+++A+G A ++SP A +T + + G+ E S+ +E+D
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 492 TEEMPNDSVLENKSLQ 507
EE P + K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
T + K E D E SE E D ++ + QEK + TS AKG
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 222 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
GP +V + KP + ++ EE + E+ + + + KP +
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638
Query: 282 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 341
Q +K T + V PV VG P K T+ + AG + + G
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688
Query: 342 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 392
PAE+S +E AV G S G + PV G P + G
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
Query: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452
P Q E+ +++ + A P+Q K SV++++A + +
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806
Query: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 512
S KV AA + Q ++K + + +V Q EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866
Query: 513 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 549
+ G+ E D + A+ + + + K Q+ AA A K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/341 (22%), Positives = 122/341 (35%), Gaps = 61/341 (17%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
+ED S + ETD E ++ + +S + E P K + + + + KGGA P
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 222 EGPNEAEVTSGKPEQEVPDAEE-----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+ KPE+E +EE E++ +GT Q + EK Q + + P
Sbjct: 259 PAKR-----AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA--PAKGTP 311
Query: 277 KEVSEEQP---VVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333
+ + P + Q A + E +S + + D + P K + +GK
Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT--- 368
Query: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393
VG PA+ESP A PG+ P + K A G Q+
Sbjct: 369 SQVGAASAPAKESPRKGAAPAP-------------PGKTGPAVAKAQA--GKREEDSQSS 413
Query: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
E S E SG +VRA P++E + +GA
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR------------------KGAAPAP 455
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
P AA Q++ G++ E S +E+D E
Sbjct: 456 PRKTGPAAA---------QVQVGKQEEDSRSSSEESDSDRE 487
Score = 34.3 bits (77), Expect = 0.46
Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)
Query: 368 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 427
K ++A + K V+ P + + E + E T + V +PS +
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123
Query: 428 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 468
K E +A G VA + KSP + +AN ET+E
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
Query: 469 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 523
+ + G+ SE+ +D+T E P+ + K+ + +E
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242
Query: 524 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 583
K+ + K L A+ K E S SE ++ EE + Q ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296
Query: 584 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 643
+L + A G + + + E + + S++ ++E
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 644 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 700
K LL AK S ++ V A A ES G P G G +V+ + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405
Query: 701 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 750
+ + SS+ +D + KP ++P+ K+ +K A P G +
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 751 VPSG--NEVSENMEEEAENQAESRAAV 775
V G E S + EE+++ E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492
Score = 32.0 bits (71), Expect = 2.3
Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)
Query: 626 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 685
QVK A+ K+ EE E E E E+A RS A + S+ + T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 686 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 723
PG G G+ S + KP + + SS+ + S L++ K
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 724 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 772
P +ESPRK A P G +G AV E S++ EE++++ E+
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 773 AAVEGTVEA 781
A + + +A
Sbjct: 425 AQAKPSGKA 433
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)
Query: 154 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 209
GE EA +KT S K + DK EK G+ + + +EP+E++
Sbjct: 1332 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1384
Query: 210 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 269
KG EG +++ S K +++ +++K +++ + K K E
Sbjct: 1385 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1434
Query: 270 VSIEEKPKEVSEEQPV 285
++K K+ + EQ V
Sbjct: 1435 SQKKKKKKKKTAEQTV 1450
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 63.5 bits (153), Expect = 7e-10
Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)
Query: 119 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 168
EEE E +E+ S E ++ + E++ AK T K
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 169 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 219
KPE D E SE E+ +K+ + + K E + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 220 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 274
AP GP A+ +GK E++ + EE S S + + + G + +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 275 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 334
P++ + P K G P V VG E + + + E+++ + L
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 335 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 394
+ +V P +SP+V + PG+ P PS +
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543
Query: 395 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 454
+ ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
VQ+ A E+ + E +E ++ SEE + P + + K+ +
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 574
AK+ R T +A A A G + + E+ S +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 629
E E LA T Q + G Q A S+ V+ + QVK
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756
Query: 630 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 689
+ +E +E + +E + K++Q N A A +A + + S PG
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812
Query: 690 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 749
++ + R P+ + + L R A +A+ PE + GS
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870
Query: 750 AVPSGNEVSENMEEEAENQAE 770
+E + EEEAE A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)
Query: 142 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 187
R EL +Y + G A++ +++S LA+P T +Q SE+ + + +
Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66
Query: 188 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 247
D + A++ + ++ +E EEA+ A P A S ++P + +EK+
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126
Query: 248 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 292
+ T+ + G+ + ++ + P++ +E TL E++G
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186
Query: 293 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 328
+A + ++ S D P+VKP V + P K + + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246
Query: 329 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 373
V Q+ G +PPA EE E + E +E+ S V+A ++ + A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 431
P G P+ G + QT + E + S E S+EET ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359
Query: 432 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 491
+++A+G A ++SP A +T + + G+ E S+ +E+D
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 492 TEEMPNDSVLENKSLQ 507
EE P + K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435
Score = 51.6 bits (122), Expect = 3e-06
Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
T + K E D E SE E D ++ + QEK + TS AKG
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 222 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 281
GP +V + KP + ++ EE + E+ + + + KP +
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638
Query: 282 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 341
Q +K T + V PV VG P K T+ + AG + + G
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688
Query: 342 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 392
PAE+S +E AV G S G + PV G P + G
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
Query: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452
P Q E+ +++ + A P+Q K SV++++A + +
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806
Query: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 512
S KV AA + Q ++K + + +V Q EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866
Query: 513 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 549
+ G+ E D + A+ + + + K Q+ AA A K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/341 (22%), Positives = 122/341 (35%), Gaps = 61/341 (17%)
Query: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
+ED S + ETD E ++ + +S + E P K + + + + KGGA P
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALP 258
Query: 222 EGPNEAEVTSGKPEQEVPDAEE-----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+ KPE+E +EE E++ +GT Q + EK Q + + P
Sbjct: 259 PAKR-----AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA--PAKGTP 311
Query: 277 KEVSEEQP---VVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333
+ + P + Q A + E +S + + D + P K + +GK
Sbjct: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT--- 368
Query: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393
VG PA+ESP A PG+ P + K A G Q+
Sbjct: 369 SQVGAASAPAKESPRKGAAPAP-------------PGKTGPAVAKAQA--GKREEDSQSS 413
Query: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453
E S E SG +VRA P++E + +GA
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR------------------KGAAPAP 455
Query: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494
P AA Q++ G++ E S +E+D E
Sbjct: 456 PRKTGPAAA---------QVQVGKQEEDSRSSSEESDSDRE 487
Score = 34.3 bits (77), Expect = 0.46
Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)
Query: 368 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 427
K ++A + K V+ P + + E + E T + V +PS +
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123
Query: 428 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 468
K E +A G VA + KSP + +AN ET+E
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
Query: 469 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 523
+ + G+ SE+ +D+T E P+ + K+ + +E
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242
Query: 524 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 583
K+ + K L A+ K E S SE ++ EE + Q ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296
Query: 584 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 643
+L + A G + + + E + + S++ ++E
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 644 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 700
K LL AK S ++ V A A ES G P G G +V+ + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405
Query: 701 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 750
+ + SS+ +D + KP ++P+ K+ +K A P G +
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 751 VPSG--NEVSENMEEEAENQAESRAAV 775
V G E S + EE+++ E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492
Score = 32.0 bits (71), Expect = 2.3
Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)
Query: 626 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 685
QVK A+ K+ EE E E E E+A RS A + S+ + T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 686 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 723
PG G G+ S + KP + + SS+ + S L++ K
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 724 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 772
P +ESPRK A P G +G AV E S++ EE++++ E+
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 773 AAVEGTVEA 781
A + + +A
Sbjct: 425 AQAKPSGKA 433
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.2 bits (152), Expect = 9e-10
Identities = 121/607 (19%), Positives = 249/607 (41%), Gaps = 90/607 (14%)
Query: 126 EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR 185
E+++ ++ +EEAR+ L +QV + + KK D L E+ +E ++ K
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK--- 1399
Query: 186 EDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 242
D ++ +EK L D L +T ++ + ++ +V S +++ +
Sbjct: 1400 ---DAEALSQRLEEKA-LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 243 ---EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 299
EEKS+S +E R + ++ +S+ +E E + E+Q + +
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE--EFERQNKQLRADM 1513
Query: 300 ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 359
E L + DVG + E E K LEQ V +E+ E E +A E + +
Sbjct: 1514 EDLMSSKD--DVGKN-------VHELEKSKRALEQQV-EEMRTQLEELEDELQATEDAKL 1563
Query: 360 EAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 418
+ Q E + +D +Q + + I+++ E + E K RA
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRD----------EQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 419 KLVPSQEETKLSVEESEA-------AGDGV---------DTKVAQGATEKSPEDKVQIAA 462
V S+++ ++ +++ EA A D V K Q E++ + +I A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 463 NEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----VLENK-- 504
+ E++ + E E + EE + + ++ +E+ N + +L+ K
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 505 ------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESE 558
L+E EEE N+EL D + + +T A+L A ++ + +S+
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTL---QVDTLNAELAAERS------AAQKSD 1784
Query: 559 NYVQAVEEFQSCLNLQEQYLEAHDR-----LLAETHYQLGLAYGYNSQYDEAVAQFSKSI 613
N Q +E L + Q LE + ++ ++G Q + A +K +
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 614 EVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALK 673
E ++ + QV++ + +YK+++E+ + +++ ++E+A+E N + L+
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 674 ATLVESS 680
L +++
Sbjct: 1905 RELDDAT 1911
Score = 57.8 bits (138), Expect = 4e-08
Identities = 144/741 (19%), Positives = 291/741 (39%), Gaps = 95/741 (12%)
Query: 95 KSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREE---LREQVYD 151
K LL++ R E + E + V+E++ T+ E +E + ++ EE L EQ+
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQ---TKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 152 AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTET 211
EA++ + AK + +E ++E E+ + ++ + ++K+ + L E
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 212 SEEAKGGAAPEGPNE--AEVTSGKPEQEVPDAEEEKS--VSGTDVQE----ECREKGGQE 263
+E +G + AE K E+E+ E++ S + + E EC + +E
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 264 ------------KQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 311
KQ +I +EE+ K+ EE+ LEK ++ E L + +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 312 GGDEPEEKVVTSENEAGKA----------------VLEQLVGQ--EVPPAEESPEVTTEA 353
DE + ++ E E A V+ +L Q E+ ES + +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 354 AEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLE 413
AE + E+ + L A +Q E + ++E ETK+
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE--ETKNHEAQI 1194
Query: 414 EKVRAKLVPSQEETKLSVEES-------EAAGDGVDTKVAQGATEKSPEDKVQIAANEET 466
+ +R + + EE +E++ E G++T + A E +V+ + +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 467 QEREEQMKE--GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDML 524
++ + Q++E + +EG + +K ++ N+ L+N S E E+ G ++ A D
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE--LDNVSTLLEEAEKKG-IKFAKDAA 1311
Query: 525 DLAKIIFKRQET-KEAQLYAAQAHLKLGEVSVESENYV-QAVEEFQSCLNLQEQYLEAHD 582
L + QE +E ++ ++ E + Q EE ++ NL++Q L
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 583 RLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIE 642
+L A+T ++ G +EA + K E + R+ + E + ++E++
Sbjct: 1372 QL-ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 643 ELKELLPEIREKIEDAKESQRSGN---VAELALKATLVESSTSGFTPGGGGSSVSMIASR 699
+L L R+ + ++ Q+ + E ++ A E R
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE-----------------RDR 1473
Query: 700 KPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSE 759
+ ++ + + + +EE R++ +A E D + S ++V +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME--------DLMSSKDDVGK 1525
Query: 760 NMEEEAENQAESRAAVEGTVE 780
N+ E +S+ A+E VE
Sbjct: 1526 NVHE----LEKSKRALEQQVE 1542
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 62.4 bits (150), Expect = 2e-09
Identities = 86/441 (19%), Positives = 177/441 (40%), Gaps = 42/441 (9%)
Query: 243 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 302
EE ++QEE + + ++ E+ + I+E +++ ++ + L ++G E E +
Sbjct: 7 EELKEKNAELQEELQLV--ETEKSEIQLHIKELKRKLETDK--IPLPQEGQVREQEGQVR 62
Query: 303 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 362
+ + + G E++ E E Q+ QE E+ +V + E E
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQ--EGQVREQE 114
Query: 363 SEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQT-SIERLTETKDGSGLEEKVR 417
+V E+ GQ E V ++G V G E Q E ++G E++ +
Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVREQEGQVREQEGQ 172
Query: 418 AKLVPSQ-EETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 476
+ Q E + V E E + ++ + + +++ E+ E+EEQM++
Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232
Query: 477 EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 536
EE G +E+ + + + + + + Q E+EE M + + + K++E
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE--------QMREQEEQMLKQKEQ 284
Query: 537 KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLG--- 593
E + + ++ E + + + E + + QE+ + + + E Q+
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 594 -LAYGYNSQYDEAVAQFSKSIEVI----------ENRMAVLNEQVKEAEGSSAEYKKEIE 642
+ Q E Q K E + E +M EQ+++ E E K+++
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 643 ELKELLPEIREKIEDAKESQR 663
E KE + E E++ + KE R
Sbjct: 405 EQKEQMREQEEQMGEQKEQMR 425
Score = 58.2 bits (139), Expect = 3e-08
Identities = 80/421 (19%), Positives = 175/421 (41%), Gaps = 38/421 (9%)
Query: 224 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQ 283
P E +V EQE E+E V + Q +E +E++G+V E+ +V E++
Sbjct: 49 PQEGQVR----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQE 100
Query: 284 PVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPA 343
V E++G E E + + + + G E++ E E Q+ QE
Sbjct: 101 GQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVR 153
Query: 344 EESPEVTTEAAEASAVEAGSEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQTS 399
E+ +V + E E +V E+ GQ E V ++G + + +
Sbjct: 154 EQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211
Query: 400 IERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQ 459
E++ + ++ G +E+ K E + V++ E + ++ + + +++
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271
Query: 460 IAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNL-E 518
E+ +++EQ ++ E+T EE +E ++ + + E + +EE++G E
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331
Query: 519 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL 578
W+ + + E KE Q++ + ++GE + + + V + + + QE+ +
Sbjct: 332 QMWEQKE------QMWEQKE-QMWKQEE--QMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Query: 579 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYK 638
+ + + Q+G + E + + + + E +M EQ+++ E E K
Sbjct: 383 RKQEEQMRKQEEQMG-------EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Query: 639 K 639
+
Sbjct: 436 E 436
Score = 56.2 bits (134), Expect = 1e-07
Identities = 81/403 (20%), Positives = 168/403 (41%), Gaps = 28/403 (6%)
Query: 117 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 176
V E+EG+ E E V + E ++REQ ++ + ++ E + + +EQ
Sbjct: 54 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 113
Query: 177 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 236
+ ++ + + + E + +V E +G + E EQ
Sbjct: 114 EGQVREQEGQVREQEGQVREQEGQV-----------REQEGQVREQEGQVREQEGQVREQ 162
Query: 237 EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 296
E E+E V + + + RE+ GQ ++ E + +E EEQ E+ E
Sbjct: 163 EGQVREQEGQV--REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 297 VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 356
E + K + G E EE+V E + K EQ+ QE E+ ++ + +
Sbjct: 221 QMGEQEEQMRKQEEQMG-EQEEQVQKQEEQVQKQE-EQMRKQEEQMREQEEQMREQEEQM 278
Query: 357 SAVEAGSEVSEKPG-QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-LEE 414
+ +E E+ G QE + ++ + + + + E++ E ++ G EE
Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMR-------EQEEQMREQEEQMREQEEQMGKQEE 331
Query: 415 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 474
++ + E+ + ++ E G+ + Q + E++++ E+ +++EEQM+
Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR-KQEEQMRKQEEQMR 390
Query: 475 EGEETEGSEEDDKENDKTEEM--PNDSVLENKSLQENEEEEIG 515
+ EE G E+ ++ ++ E+M + + E K +EE +G
Sbjct: 391 KQEEQMG-EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 50.1 bits (118), Expect = 8e-06
Identities = 67/371 (18%), Positives = 154/371 (41%), Gaps = 25/371 (6%)
Query: 117 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 176
V E+EG+ E E V + E ++REQ ++ + ++ E + + +EQ
Sbjct: 89 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 148
Query: 177 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 236
+ ++ + + + E + +V + E + + G E ++ G+ E+
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQM--GEQEE 206
Query: 237 EVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 295
++ + EE+ + E+ + QE+Q GE ++++ ++V +++ + KQ +
Sbjct: 207 QMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE--QMRKQEEQM 264
Query: 296 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 355
+ E + + + ++ E++ T E E E+ + ++ E E E E
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEE 324
Query: 356 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 415
+ +K E K+ +G+Q + Q E++ + EE+
Sbjct: 325 QMGKQEEQMWEQK---EQMWEQKEQMWKQEEQMGEQEE-QMQKQEEQVRKQ------EEQ 374
Query: 416 VRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ-EREEQMK 474
+R + +++ + ++ E G+ E+ E K Q+ EE E++EQM+
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGE---------QKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 475 EGEETEGSEED 485
+ EE G +++
Sbjct: 426 KQEEHMGEQKE 436
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/172 (20%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 113 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 172
E + +EE+ + E++ L + EE E EQ+ + ++E+ ++ E++ + E
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE---QEEQMREQEEQMREQEEQ 318
Query: 173 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 232
+EQ+ +M K + + + E +E++ W +E + G E + E
Sbjct: 319 MREQEEQMGKQEEQMWEQKEQMWEQKEQM-----W----KQEEQMGEQEEQMQKQEEQVR 369
Query: 233 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQ 283
K E+++ EE+ ++++ + G Q++Q GE + E+ +++ E++
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 62.4 bits (150), Expect = 2e-09
Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)
Query: 98 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 157
LE + G L+ + EE E + ++ +E E LR QV D K
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511
Query: 158 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 216
+A+ E S K E + ++ + E++ + ++ AE + ++ + + E
Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+A + + ++ + +E+ V+ ++EE + Q+ + E + EE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628
Query: 277 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 333
+E+ Q + + ++AE + ++ +E+ GKA +
Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 334 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 388
+L QE+ + E T + AAE + +E + Q + + + +
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 389 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 434
Q E + + ++ + L K RA +EE++ + E+S
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 435 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 485
EAA + A+ + + ED + A E E+ GE T +E
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 486 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 533
+ EN++ + D + + L+E EE + L A D L + ++
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 534 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 579
+ E ++ A A+ L+LG + +E+ +++ E E ++ Q E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 580 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 639
R AE Q LA +EA Q ++E +E L +V+EA ++
Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030
Query: 640 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 697
E +L E +K A+E + V E L+ TL + + G A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085
Query: 698 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 757
+R+ + A + V+ +R+ + + ++A++ KQ E A
Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134
Query: 758 SENMEEEAENQAESRAAVE 776
+E + +EAE +A RA E
Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153
Score = 57.0 bits (136), Expect = 7e-08
Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)
Query: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 173
+ E + LVE+ + EE+ A EK A K E +S A+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 174 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 231
++ +E+E + + + + E +E+V +L E + + K E E
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015
Query: 232 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 289
K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070
Query: 290 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 348
++ + ++ L + +E EE V +E EA ++ + + + AEE +
Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 349 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 401
+A AE EA E + + E L + D + +QT + +
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 402 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 461
LT + LEE K + +E +L E +EAA + + E+ ++
Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 462 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 517
A E + R +++ + T+ EE +K EE SV E L++ EE++
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 518 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 574
LA ML K Q +EA A+A L + E++ E +Q +E Q L
Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 634
E+ L AE QL + S E ++ R+A ++ AE +
Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 635 AEYKKEIEELKELL 648
++K+ EE+ E L
Sbjct: 2404 QRFRKQAEEIGEKL 2417
Score = 35.0 bits (79), Expect = 0.27
Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)
Query: 140 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 199
+A EL +Q + E+ + + + +A+ ++ Q + + SAE E
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383
Query: 200 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 259
++ L + ++ A+ A E+ E+ E+ V ++Q + +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 260 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 319
E+ E I +E + +++ +E ++ L+ + V+ E L + + ++
Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501
Query: 320 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 377
++ E E KA LEQL EV A++ E + E V+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 378 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 432
+ V Q + + E L E LEE+ RA L S+E T V
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 433 ESEAAGDGVDTKVAQGATEKSPE 455
++ +G D + A E PE
Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643
Score = 32.7 bits (73), Expect = 1.3
Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 570
T +AQL + K +V SE+ YV +
Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 571 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 628
L QY++ L + LA ++ E +A+ ++E + ++A + Q K
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385
Query: 629 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 663
EA + + K+ I EEL++L EI+ K A+ ++R
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 664 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 723
S E ++ ++ + GG + + +R A + L +R+
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502
Query: 724 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 770
++ES RK A+ + K E E A+ + E+ EE E E +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 771 SRAAVEGTVEAGATVE 786
+ A+E T + A E
Sbjct: 1563 VQVALE-TAQRSAEAE 1577
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 62.4 bits (150), Expect = 2e-09
Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)
Query: 98 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 157
LE + G L+ + EE E + ++ +E E LR QV D K
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1515
Query: 158 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 216
+A+ E S K E + ++ + E++ + ++ AE + ++ + + E
Sbjct: 1516 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+A + + ++ + +E+ V+ ++EE + Q+ + E + EE
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1632
Query: 277 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 333
+E+ Q + + ++AE + ++ +E+ GKA +
Sbjct: 1633 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689
Query: 334 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 388
+L QE+ + E T + AAE + +E + Q + + + +
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Query: 389 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 434
Q E + + ++ + L K RA +EE++ + E+S
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 435 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 485
EAA + A+ + + ED + A E E+ GE T +E
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 486 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 533
+ EN++ + D + + L+E EE + L A D L + ++
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923
Query: 534 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 579
+ E ++ A A+ L+LG + +E+ +++ E E ++ Q E
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 580 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 639
R AE Q LA +EA Q ++E +E L +V+EA ++
Sbjct: 1984 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2034
Query: 640 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 697
E +L E +K A+E + V E L+ TL + + G A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2089
Query: 698 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 757
+R+ + A + V+ +R+ + + ++A++ KQ E A
Sbjct: 2090 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2138
Query: 758 SENMEEEAENQAESRAAVE 776
+E + +EAE +A RA E
Sbjct: 2139 AEKLRKEAEQEAARRAQAE 2157
Score = 57.0 bits (136), Expect = 7e-08
Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)
Query: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 173
+ E + LVE+ + EE+ A EK A K E +S A+
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 174 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 231
++ +E+E + + + + E +E+V +L E + + K E E
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2019
Query: 232 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 289
K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2074
Query: 290 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 348
++ + ++ L + +E EE V +E EA ++ + + + AEE +
Sbjct: 2075 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130
Query: 349 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 401
+A AE EA E + + E L + D + +QT + +
Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190
Query: 402 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 461
LT + LEE K + +E +L E +EAA + + E+ ++
Sbjct: 2191 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248
Query: 462 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 517
A E + R +++ + T+ EE +K EE SV E L++ EE++
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 518 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 574
LA ML K Q +EA A+A L + E++ E +Q +E Q L
Sbjct: 2309 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2362
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 634
E+ L AE QL + S E ++ R+A ++ AE +
Sbjct: 2363 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 635 AEYKKEIEELKELL 648
++K+ EE+ E L
Sbjct: 2408 QRFRKQAEEIGEKL 2421
Score = 35.0 bits (79), Expect = 0.27
Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)
Query: 140 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 199
+A EL +Q + E+ + + + +A+ ++ Q + + SAE E
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2387
Query: 200 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 259
++ L + ++ A+ A E+ E+ E+ V ++Q + +
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447
Query: 260 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 319
E+ E I +E + +++ +E ++ L+ + V+ E L + + ++
Sbjct: 2448 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2505
Query: 320 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 377
++ E E KA LEQL EV A++ E + E V+
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 378 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 432
+ V Q + + E L E LEE+ RA L S+E T V
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 433 ESEAAGDGVDTKVAQGATEKSPE 455
++ +G D + A E PE
Sbjct: 2626 ATKTLPNGRDA-LDGPAAEAEPE 2647
Score = 32.7 bits (73), Expect = 1.3
Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + +
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1291
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 570
T +AQL + K +V SE+ YV +
Sbjct: 1292 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330
Query: 571 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 628
L QY++ L + LA ++ E +A+ ++E + ++A + Q K
Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1389
Query: 629 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 663
EA + + K+ I EEL++L EI+ K A+ ++R
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
Query: 664 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 723
S E ++ ++ + GG + + +R A + L +R+
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1506
Query: 724 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 770
++ES RK A+ + K E E A+ + E+ EE E E +
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 771 SRAAVEGTVEAGATVE 786
+ A+E T + A E
Sbjct: 1567 VQVALE-TAQRSAEAE 1581
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 62.4 bits (150), Expect = 2e-09
Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)
Query: 98 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 157
LE + G L+ + EE E + ++ +E E LR QV D K
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511
Query: 158 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 216
+A+ E S K E + ++ + E++ + ++ AE + ++ + + E
Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 276
+A + + ++ + +E+ V+ ++EE + Q+ + E + EE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628
Query: 277 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 333
+E+ Q + + ++AE + ++ +E+ GKA +
Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 334 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 388
+L QE+ + E T + AAE + +E + Q + + + +
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 389 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 434
Q E + + ++ + L K RA +EE++ + E+S
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 435 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 485
EAA + A+ + + ED + A E E+ GE T +E
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 486 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 533
+ EN++ + D + + L+E EE + L A D L + ++
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 534 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 579
+ E ++ A A+ L+LG + +E+ +++ E E ++ Q E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 580 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 639
R AE Q LA +EA Q ++E +E L +V+EA ++
Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030
Query: 640 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 697
E +L E +K A+E + V E L+ TL + + G A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085
Query: 698 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 757
+R+ + A + V+ +R+ + + ++A++ KQ E A
Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134
Query: 758 SENMEEEAENQAESRAAVE 776
+E + +EAE +A RA E
Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153
Score = 57.0 bits (136), Expect = 7e-08
Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)
Query: 121 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 173
+ E + LVE+ + EE+ A EK A K E +S A+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 174 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 231
++ +E+E + + + + E +E+V +L E + + K E E
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015
Query: 232 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 289
K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070
Query: 290 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 348
++ + ++ L + +E EE V +E EA ++ + + + AEE +
Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 349 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 401
+A AE EA E + + E L + D + +QT + +
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 402 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 461
LT + LEE K + +E +L E +EAA + + E+ ++
Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 462 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 517
A E + R +++ + T+ EE +K EE SV E L++ EE++
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 518 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 574
LA ML K Q +EA A+A L + E++ E +Q +E Q L
Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358
Query: 575 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 634
E+ L AE QL + S E ++ R+A ++ AE +
Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 635 AEYKKEIEELKELL 648
++K+ EE+ E L
Sbjct: 2404 QRFRKQAEEIGEKL 2417
Score = 35.0 bits (79), Expect = 0.27
Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)
Query: 140 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 199
+A EL +Q + E+ + + + +A+ ++ Q + + SAE E
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383
Query: 200 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 259
++ L + ++ A+ A E+ E+ E+ V ++Q + +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 260 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 319
E+ E I +E + +++ +E ++ L+ + V+ E L + + ++
Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501
Query: 320 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 377
++ E E KA LEQL EV A++ E + E V+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 378 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 432
+ V Q + + E L E LEE+ RA L S+E T V
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 433 ESEAAGDGVDTKVAQGATEKSPE 455
++ +G D + A E PE
Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643
Score = 32.7 bits (73), Expect = 1.3
Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)
Query: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 514
++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287
Query: 515 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 570
T +AQL + K +V SE+ YV +
Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 571 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 628
L QY++ L + LA ++ E +A+ ++E + ++A + Q K
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385
Query: 629 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 663
EA + + K+ I EEL++L EI+ K A+ ++R
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 664 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 723
S E ++ ++ + GG + + +R A + L +R+
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502
Query: 724 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 770
++ES RK A+ + K E E A+ + E+ EE E E +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 771 SRAAVEGTVEAGATVE 786
+ A+E T + A E
Sbjct: 1563 VQVALE-TAQRSAEAE 1577
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.301 0.123 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,518,248
Number of Sequences: 37866
Number of extensions: 1595878
Number of successful extensions: 23818
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 1389
Number of HSP's that attempted gapping in prelim test: 9181
Number of HSP's gapped (non-prelim): 9243
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.