BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo sapiens] (788 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ... 1520 0.0 gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ... 1456 0.0 gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo ... 610 e-174 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 94 4e-19 gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 94 6e-19 gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 94 6e-19 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 92 2e-18 gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 75 2e-13 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 74 7e-13 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 73 9e-13 gi|153945728 microtubule-associated protein 1B [Homo sapiens] 72 2e-12 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 72 3e-12 gi|16262452 cingulin [Homo sapiens] 70 6e-12 gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 68 3e-11 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 8e-11 gi|104526627 triadin [Homo sapiens] 67 8e-11 gi|24415404 MDN1, midasin homolog [Homo sapiens] 66 1e-10 gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 65 2e-10 gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 65 2e-10 gi|210032580 SET domain containing 1B [Homo sapiens] 65 3e-10 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 64 4e-10 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 64 7e-10 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 64 7e-10 gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 64 7e-10 gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 64 7e-10 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 63 9e-10 gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 62 2e-09 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 2e-09 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 2e-09 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 2e-09 >gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo sapiens] Length = 788 Score = 1520 bits (3935), Expect = 0.0 Identities = 788/788 (100%), Positives = 788/788 (100%) Query: 1 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP Sbjct: 1 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60 Query: 61 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG Sbjct: 61 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120 Query: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK Sbjct: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180 Query: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE Sbjct: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240 Query: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL Sbjct: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300 Query: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG Sbjct: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360 Query: 361 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP 420 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP Sbjct: 361 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP 420 Query: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS 480 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS Sbjct: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS 480 Query: 481 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 540 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY Sbjct: 481 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 540 Query: 541 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY 600 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY Sbjct: 541 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY 600 Query: 601 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 660 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ Sbjct: 601 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 660 Query: 661 RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR 720 RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR Sbjct: 661 RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR 720 Query: 721 KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG 780 KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG Sbjct: 721 KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG 780 Query: 781 ATVESTAC 788 ATVESTAC Sbjct: 781 ATVESTAC 788 >gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo sapiens] Length = 790 Score = 1456 bits (3770), Expect = 0.0 Identities = 752/757 (99%), Positives = 755/757 (99%) Query: 32 DKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 91 +++ LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY Sbjct: 34 NRIIHLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 93 Query: 92 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 151 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM Sbjct: 94 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 153 Query: 152 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 211 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE Sbjct: 154 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 213 Query: 212 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 271 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE Sbjct: 214 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 273 Query: 272 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 331 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE Sbjct: 274 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333 Query: 332 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 391 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP Sbjct: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393 Query: 392 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 451 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS Sbjct: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453 Query: 452 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 511 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE Sbjct: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513 Query: 512 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 571 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL Sbjct: 514 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 573 Query: 572 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 631 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS Sbjct: 574 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 633 Query: 632 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 691 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV Sbjct: 634 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 693 Query: 692 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 751 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS Sbjct: 694 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 753 Query: 752 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC Sbjct: 754 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 790 >gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo sapiens] Length = 449 Score = 610 bits (1574), Expect = e-174 Identities = 341/468 (72%), Positives = 366/468 (78%), Gaps = 23/468 (4%) Query: 322 ENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVN 381 E+ A AV +LV + E+ P +T A + +++ SE + G L Sbjct: 4 ESTATAAVAAELVSAD--KIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHL------- 54 Query: 382 GPSVVGD-QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVD 440 V+GD + L K G E A + +L+ E+ G+ ++ Sbjct: 55 ---VMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALE 111 Query: 441 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500 + + ED+ + N+ +ETEGSEEDDKENDKTEEMPNDSVLE Sbjct: 112 GVHVEEEEGEKTEDESLVENNDNI----------DETEGSEEDDKENDKTEEMPNDSVLE 161 Query: 501 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 560 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ Sbjct: 162 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221 Query: 561 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 620 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV Sbjct: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281 Query: 621 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 680 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS Sbjct: 282 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 341 Query: 681 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 740 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE Sbjct: 342 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 401 Query: 741 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC Sbjct: 402 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 449 Score = 280 bits (717), Expect = 3e-75 Identities = 208/493 (42%), Positives = 273/493 (55%), Gaps = 49/493 (9%) Query: 1 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP Sbjct: 1 MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60 Query: 61 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG Sbjct: 61 AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120 Query: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180 EKTEDESLVENNDNIDE E ++ D E E+KSL + E ++ + E+ Sbjct: 121 EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL-- 178 Query: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240 + +D++K + QE ++EA+ AA EV S + E V E Sbjct: 179 -AWDMLDLAKIIFKRQE------------TKEAQLYAAQAHLKLGEV-SVESENYVQAVE 224 Query: 241 EEKSVSGTDVQE-ECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAES 299 E +S Q E ++ E ++ ++ + ++ V K +E Sbjct: 225 EFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQ---YDEAVAQFSKSIEVIENRMAV 281 Query: 300 LDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEA 359 L+ VK + G +K + E + E++ ++ ++ S V A +A+ VE+ Sbjct: 282 LNEQVKEAE-GSSAEYKKEIEELKELLPEIREKI--EDAKESQRSGNVAELALKATLVES 338 Query: 360 GSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLV 419 S PG G + S++ + P + +S +T+ + VR K Sbjct: 339 -STSGFTPG---------GGGSSVSMIASRKPTDGASSSNCVTD------ISHLVRKKRK 382 Query: 420 PSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEG 479 P +E S + +A + +V G+ + P + NE ++ EE+ + E+ Sbjct: 383 PEEE----SPRKDDAKKAKQEPEVNGGSGDAVP------SGNEVSENMEEEAENQAESRA 432 Query: 480 SEEDDKENDKTEE 492 + E E T E Sbjct: 433 AVEGTVEAGATVE 445 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 94.4 bits (233), Expect = 4e-19 Identities = 104/404 (25%), Positives = 168/404 (41%), Gaps = 34/404 (8%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175 E+EE +K + E E E+ ++ R Q + GE+E + E++ + E +KE + Sbjct: 698 EKEEWKKRDGE---EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754 Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGA-APEGPNEAEVTSGKPEQ 234 + E+G E+++ + EE + K + +E KG +G E E T G+ E+ Sbjct: 755 GK-EEGEGEEVEGEREKEEGERKKE------ERAGKEEKGEEEGDQGEGEEEETEGRGEE 807 Query: 235 EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 294 + EE V G +V+E E+ +E++GE EE+ E++G E Sbjct: 808 K----EEGGEVEGGEVEEGKGEREEEEEEGE------------GEEEEGEGEEEEGEGEE 851 Query: 295 VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 354 E E G +E EE E E G+ E+ E E E E Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911 Query: 355 SAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKV 414 E G E+ G+E ++ G G+ E + E E +G G EE Sbjct: 912 GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG- 970 Query: 415 RAKLVPSQEETKLSVEESEAAGDGVDTK-VAQGATEKSPEDKVQIAANEETQEREEQMKE 473 EE + EE E G+G + + +G E E++ + EE + E E Sbjct: 971 ----EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026 Query: 474 GEETEGSEEDDKENDKTEEMPNDSV-LENKSLQENEEEEIGNLE 516 GEE EG E+++ ++ EE + EN+ +E EEEE G + Sbjct: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070 Score = 88.2 bits (217), Expect = 3e-17 Identities = 113/442 (25%), Positives = 174/442 (39%), Gaps = 54/442 (12%) Query: 116 EEEEGEKTEDESLVENNDNIDEEA-REELREQVYDAMGEKEEAKKTEDKSLAKPETDKE- 173 E+ +G E++ + N +N+ R+E E + D + +K E + + KS+ + E E Sbjct: 594 EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEG 653 Query: 174 ----------------QDSEMEKG----GREDMDISKSAE--------------EPQEKV 199 QD E EKG GR +M+ E E QE+ Sbjct: 654 RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713 Query: 200 DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGG 259 + E ++E + G E E + E+E + E ++ G +V+ E ++ G Sbjct: 714 EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773 Query: 260 QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVV 319 + K+ E EEK +E ++ E +G E E E + V+ G E EE Sbjct: 774 ERKK-EERAGKEEKGEEEGDQGEGEEEETEGRGEEKE-EGGEVEGGEVEEGKGEREE--- 828 Query: 320 TSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE-VSEKPGQEAPVLPKDG 378 E E G+ E+ G+ EE E E E E G E E+ G+E ++ Sbjct: 829 --EEEEGEGEEEEGEGE-----EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881 Query: 379 AVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDG 438 G + E + E +G G EE+ K EE + EE E G+G Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941 Query: 439 VD----TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494 D + +G E E+ E E EE EGEE EG E ++E + EE Sbjct: 942 EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGE 1000 Query: 495 NDSVLENKSLQENEEEEIGNLE 516 + E + E EEEE G +E Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVE 1022 Score = 82.0 bits (201), Expect = 2e-15 Identities = 106/376 (28%), Positives = 153/376 (40%), Gaps = 53/376 (14%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEE--AREELREQVYDAMGEKEEAKKTEDKSLAKP 168 EG EE EGE+ E E E + EE +EE E+ D GE EE ++TE + K Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD-QGEGEE-EETEGRGEEKE 809 Query: 169 ETDKEQDSEME--KGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG---GAAPEGPN 223 E + + E+E KG RE+ + EE + + + E E KG G EG Sbjct: 810 EGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE 869 Query: 224 EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 283 E E G+ E+E + E E+ G +EE +G +E +GE EE+ E E+ Sbjct: 870 EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG----EEEEGEGKGEEEG 925 Query: 284 VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL---VGQEVPP 340 E +G E E E D G E EE E E G+ E+ G+E Sbjct: 926 EEGEGEGEEEEGEGEGEDGE------GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979 Query: 341 AEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIER 400 E E E E E G E E G+E +G G E + +E Sbjct: 980 EGEEEEGEGEGEEEEGEEEGEEEGE--GEE------EGEGEGEE--------EEEGEVEG 1023 Query: 401 LTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAA 460 E ++G G E +EE + EE E G+G + + E++ + Sbjct: 1024 EVEGEEGEGEGE---------EEEGEEEGEEREKEGEGEENR------RNREEEEEEEGK 1068 Query: 461 NEETQEREEQMKEGEE 476 +ET E E + ++GEE Sbjct: 1069 YQETGEEENERQDGEE 1084 Score = 80.5 bits (197), Expect = 6e-15 Identities = 106/450 (23%), Positives = 177/450 (39%), Gaps = 65/450 (14%) Query: 120 GEKTEDESLVENNDNIDEEAREELRE------QVYDAMGEKEEAKKTE---DKSLAKPET 170 GE T+D +L EN+D+ + E E++E V + + A E D+ + PE Sbjct: 530 GELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPE- 588 Query: 171 DKEQDSEMEKGGREDMDISKSAEE------PQEKVDLTLDWLTETSEEAKG--------- 215 +KE + + G E+ ++ + E +EK ++ D LT+ +E ++G Sbjct: 589 EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAE 648 Query: 216 --------GAAPEGPNEAE-------------------VTSGKPEQEVPDAEEEKSVSGT 248 G EG + AE G+ E+E+ + EE K G Sbjct: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708 Query: 249 DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVD 308 + +++ RE+G Q+++ + + E+ EE+ E++ E + E V+ Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE--- 765 Query: 309 VGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPG 368 G E EE E AGK + G + EE E E E G EV E G Sbjct: 766 -GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824 Query: 369 QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS 428 E ++G G++ E + E +G G EE + EE + Sbjct: 825 -EREEEEEEGEGEEEEGEGEEEEGEGE------EEEGEGKGEEEGEEGEGEEEGEEGEGE 877 Query: 429 VEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQM--KEGEETEGSEEDDKE 486 EE E G+G + +G E+ + + E +E E +EGEE EG E+++ Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937 Query: 487 NDKTEEMPNDSVLENKSLQENEEEEIGNLE 516 + E+ + E + EEE G E Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967 Score = 65.5 bits (158), Expect = 2e-10 Identities = 74/269 (27%), Positives = 108/269 (40%), Gaps = 34/269 (12%) Query: 107 GNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA 166 G +EG VEE +GE+ E+E E + +EE GE+EE + E++ Sbjct: 811 GGEVEGGEVEEGKGEREEEE---EEGEGEEEEGE-----------GEEEEGEGEEEEGEG 856 Query: 167 KPETDKEQDSEMEKG------GREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPE 220 K E + E+ E+G G E+ + EE + + + E E +G E Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE-------EEEGEGEGEEEGE 909 Query: 221 GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEE 280 G E E GK E+E + E E + + E E G+E++GE EE E EE Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969 Query: 281 QPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP 340 E +G E E E + + G +E E + E G+ E+ EV Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE------EEGEGEGEEEEEGEVEG 1023 Query: 341 AEESPEVTTEAAEASAVEAGSEVSEKPGQ 369 E E E E E G E EK G+ Sbjct: 1024 EVEGEEGEGEGEEEEGEEEGEE-REKEGE 1051 Score = 63.2 bits (152), Expect = 9e-10 Identities = 86/338 (25%), Positives = 141/338 (41%), Gaps = 39/338 (11%) Query: 92 GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEE------AREELRE 145 G+ E +E G + EEEEGE E+E E + EE EE E Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864 Query: 146 QVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMDISKSAEEPQEKVDLT 202 + GE+ E + E++ + E + E + E E+G G E+ + EE + K + Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE-- 922 Query: 203 LDWLTETSEEAKG-GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKG--- 258 E EE +G G EG E E G+ E+E + E E+ + +EE +G Sbjct: 923 -----EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977 Query: 259 ---GQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPE 315 G+E++GE EE+ +E EE+ E +G E E ++ V+ + G+ E Sbjct: 978 EGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE 1036 Query: 316 EKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375 E+ E G+ ++ G+E E E E E G E +E+ Q+ Sbjct: 1037 EE----GEEEGEEREKEGEGEENRRNREE----EEEEEGKYQETGEEENER--QDGEEYK 1086 Query: 376 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413 K + G G + ++ +T T+ G+G E++ Sbjct: 1087 KVSKIKGSVKYGKHKTYQKKS----VTNTQ-GNGKEQR 1119 Score = 30.8 bits (68), Expect = 5.1 Identities = 25/96 (26%), Positives = 37/96 (38%), Gaps = 5/96 (5%) Query: 684 PGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEE----ESPRKDDAKKAKQEP 739 PG G ++ K DG + H + ++ EE E ++ + ++E Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748 Query: 740 EVNGGSGDAVPSGNEVSENME-EEAENQAESRAAVE 774 E G G G EV E EE E + E RA E Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784 >gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo sapiens] Length = 916 Score = 93.6 bits (231), Expect = 6e-19 Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%) Query: 100 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 154 ++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+ Sbjct: 447 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 505 Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214 AKK+ K+ A PE +E+ + E+ G+E+ + E E AK Sbjct: 506 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 544 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 271 A EG +E E +S K E E + E E G + + + EK +EK EV E Sbjct: 545 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 603 Query: 272 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 322 EKP++ P +E++G + VE + P K PV+ G P K E Sbjct: 604 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 663 Query: 323 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 377 + K+ +E+ VP P EE+ E EV E P +E ++ Sbjct: 664 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 723 Query: 378 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 436 + P ++P++ + E +T TK LE++ + + P Q+E E+ +A G Sbjct: 724 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 779 Query: 437 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 496 +G + K K IA N E + +EE +E +E +GS ++++ T + Sbjct: 780 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 837 Query: 497 SVLENKSLQENEEEEI 512 E K ++EE+ + Sbjct: 838 PADEKKGGDKSEEKVV 853 Score = 69.7 bits (169), Expect = 1e-11 Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%) Query: 97 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156 E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE Sbjct: 505 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 557 Query: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 215 + + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK Sbjct: 558 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616 Query: 216 ------------------------------------------------GAAP--EGPNEA 225 G +P + P E Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676 Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285 + S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++ Sbjct: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 732 Query: 286 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 345 +AES PV +E +VVT ++ K LE+ +E P ++ Sbjct: 733 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 772 Query: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 405 E E + E GS+ K ++ +D AVNG +E + +E+ T+ K Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 819 Query: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 464 GSG EE+ LS + + GD + KV T EK + A T Sbjct: 820 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 874 Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500 + K E E EE K E++ + ++++ Sbjct: 875 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 910 Score = 53.9 bits (128), Expect = 6e-07 Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%) Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 424 P + + P V + ++ + E + ETK + S +EE + A V +EE Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 487 Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 484 K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D Sbjct: 488 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 540 Query: 485 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 542 + ++D+ EE S E S +E E+E G E A+ + E KE Sbjct: 541 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 584 Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 602 E VE ++ A +E E+ +A + + G + S +E Sbjct: 585 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637 Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 662 V E + + + E +G S K +EE K P + +E+AK Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 696 Query: 663 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 722 G + + V+ + + +K + V ++ + K K Sbjct: 697 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 755 Query: 723 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 782 E K++ K +QE E G+ G E ++ A+ + AV G VE Sbjct: 756 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 811 Query: 783 VE 784 VE Sbjct: 812 VE 813 Score = 39.7 bits (91), Expect = 0.011 Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%) Query: 365 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 424 +KP EAP L + + E E LT + + K K ++E Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496 Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 472 + EE E A K ++ +K + EE +E +E K Sbjct: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556 Query: 473 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 520 EGE+ EG E + E ++ E E K ++E EE EL D Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 604 Score = 32.7 bits (73), Expect = 1.3 Identities = 78/437 (17%), Positives = 162/437 (37%), Gaps = 59/437 (13%) Query: 388 DQTPIEPQTSIERLTETK-----DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK 442 DQ E + ++E + K D LEE + +EE +L +++EAA + Sbjct: 151 DQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLR-DDTEAAIRALRKD 209 Query: 443 VAQGATEKSPEDKVQIAANEE-----TQEREEQMKEGEETEGSEEDDKENDKTEEMPNDS 497 + + + K DK + +E + EE + + S + D + + + Sbjct: 210 IEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTA 269 Query: 498 VLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA------QLYAAQAHLKLGEV 551 + E +S E+ ++ + W AK+ ++ KEA ++ + L+ + Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSI 329 Query: 552 SVES--------ENYVQAVEE--------FQSCLNLQEQYLEAHDRLLAETHYQLGLAYG 595 +ES E + +EE +Q + E L +A + Sbjct: 330 ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLN 389 Query: 596 YNSQYDEAVAQFSKSIEVIENRMAV-----------------LNEQVKEAEGSSAEYKKE 638 D +A + K +E E R + ++ ++++ + + + K + Sbjct: 390 VKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQ 449 Query: 639 IEELKELLPEIREKIEDAKESQRSGNVA---ELALKATLVESSTSGFTPGGGGSSVSMIA 695 + ++E++ E K+ED K A ELA+ + + + +A Sbjct: 450 HKFVEEIIEET--KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA 507 Query: 696 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755 ++K A++ ++ +K + E + +++ + AK + GGS S E Sbjct: 508 AKKSPVKATAP----EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563 Query: 756 SENMEEEAENQAESRAA 772 E E E E +AE A Sbjct: 564 GEQEEGETEAEAEGEEA 580 >gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo sapiens] Length = 540 Score = 93.6 bits (231), Expect = 6e-19 Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%) Query: 100 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 154 ++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+ Sbjct: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 129 Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214 AKK+ K+ A PE +E+ + E+ G+E+ + E E AK Sbjct: 130 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 168 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 271 A EG +E E +S K E E + E E G + + + EK +EK EV E Sbjct: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 227 Query: 272 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 322 EKP++ P +E++G + VE + P K PV+ G P K E Sbjct: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287 Query: 323 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 377 + K+ +E+ VP P EE+ E EV E P +E ++ Sbjct: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347 Query: 378 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 436 + P ++P++ + E +T TK LE++ + + P Q+E E+ +A G Sbjct: 348 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 403 Query: 437 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 496 +G + K K IA N E + +EE +E +E +GS ++++ T + Sbjct: 404 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 461 Query: 497 SVLENKSLQENEEEEI 512 E K ++EE+ + Sbjct: 462 PADEKKGGDKSEEKVV 477 Score = 69.7 bits (169), Expect = 1e-11 Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%) Query: 97 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156 E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE Sbjct: 129 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 181 Query: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 215 + + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK Sbjct: 182 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240 Query: 216 ------------------------------------------------GAAP--EGPNEA 225 G +P + P E Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300 Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285 + S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++ Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 356 Query: 286 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 345 +AES PV +E +VVT ++ K LE+ +E P ++ Sbjct: 357 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 396 Query: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 405 E E + E GS+ K ++ +D AVNG +E + +E+ T+ K Sbjct: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 443 Query: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 464 GSG EE+ LS + + GD + KV T EK + A T Sbjct: 444 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498 Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500 + K E E EE K E++ + ++++ Sbjct: 499 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534 Score = 53.9 bits (128), Expect = 6e-07 Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%) Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 424 P + + P V + ++ + E + ETK + S +EE + A V +EE Sbjct: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111 Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 484 K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D Sbjct: 112 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 164 Query: 485 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 542 + ++D+ EE S E S +E E+E G E A+ + E KE Sbjct: 165 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 208 Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 602 E VE ++ A +E E+ +A + + G + S +E Sbjct: 209 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261 Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 662 V E + + + E +G S K +EE K P + +E+AK Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 320 Query: 663 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 722 G + + V+ + + +K + V ++ + K K Sbjct: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 379 Query: 723 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 782 E K++ K +QE E G+ G E ++ A+ + AV G VE Sbjct: 380 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435 Query: 783 VE 784 VE Sbjct: 436 VE 437 Score = 39.7 bits (91), Expect = 0.011 Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%) Query: 365 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 424 +KP EAP L + + E E LT + + K K ++E Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120 Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 472 + EE E A K ++ +K + EE +E +E K Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180 Query: 473 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 520 EGE+ EG E + E ++ E E K ++E EE EL D Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 228 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 92.0 bits (227), Expect = 2e-18 Identities = 109/437 (24%), Positives = 179/437 (40%), Gaps = 57/437 (13%) Query: 111 EGVHVEEEEGE--KTEDESLVENNDNIDEEAREELR---------EQVYDAMGEKEEAKK 159 EGV E EG+ + E E+ E+ D EA E + E ++ E E A+ Sbjct: 1849 EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEA 1908 Query: 160 TEDKSLAKPETDK------EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213 E + A+PET+ E + E E G E + ++A+E + + + + S+EA Sbjct: 1909 PEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE--SQEA 1966 Query: 214 KGGAAPEGPN----EAEVTSGKPEQEV-PDAEEEKSVSGTDVQEECREKGGQEKQGEVIV 268 + A PE + E EV + + E E P++E+ ++ +E E+ E G Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG---- 2022 Query: 269 SIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKA 328 +E +PK EE V E Q T + + ES + E E +V +E EA Sbjct: 2023 -VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081 Query: 329 V----LEQLVGQEVPPAE--ESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNG 382 ++ G+ P +E E+PE EA +A +EA P E P+ + Sbjct: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA-------PETEGEAQPESEGIEA 2134 Query: 383 PSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS-VEESEAAGD---- 437 P G+ P +E + E + A+ + + +L VE EA G+ Sbjct: 2135 PEAEGEAQP--ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192 Query: 438 --GVDTKVAQGATEKSPE-DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494 G++ A+G E PE + V+ EE + E + E E EG + + E + E Sbjct: 2193 SEGIEAPEAEG--EAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250 Query: 495 NDSVLENKSLQENEEEE 511 + SL + + EE Sbjct: 2251 GSPQV---SLGDGQSEE 2264 Score = 81.6 bits (200), Expect = 3e-15 Identities = 164/797 (20%), Positives = 287/797 (36%), Gaps = 98/797 (12%) Query: 21 IEDVPAPSTS--------ADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL 72 +ED PA ST+ A+ E ++ +K + MG + + + Sbjct: 1633 LEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQI 1692 Query: 73 LGKKYGE-TANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVEN 131 L +K GE T E E + R G G G+ +G ++ E Sbjct: 1693 LQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGL----SQGPGVDEGEDGEG 1748 Query: 132 NDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET-DKEQDSE-MEKGGREDMDIS 189 + ++ + +L E DAM ++ E K ++ A E + EQ+ E + + G S Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808 Query: 190 KSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249 + Q + D S+ A+G APE EA+ S E P+AE + + + Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES--EGVEAPEAEGDAQEAEGE 1866 Query: 250 VQEECREKGGQEKQGEVIVSIE--EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPV 307 Q E + E +GE E E P+ E QP E +G + P + V Sbjct: 1867 AQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQP----ESEGAEAPEAEKEAQPETESV 1922 Query: 308 DV----GGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAE--ESPEVTTEAA-EASAVEAG 360 + G DEPE + +E + + ++ GQ P +E ES E EA E+ VEA Sbjct: 1923 EALETEGEDEPESE--GAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980 Query: 361 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTS-------------------IERL 401 E E P+ V P G+ E + +E Sbjct: 1981 EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040 Query: 402 TETKDGSGLEEKVRAKLVPSQEETK-----LSVEESEAAGDGVDTKVAQGATEKSPEDKV 456 T+ +G E + ++EE + + E EA + D + E PE + Sbjct: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100 Query: 457 QIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516 A E + ++ + E ETEG + + E + E ++ E++ ++ + E G + Sbjct: 2101 VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAE--GEAQ 2158 Query: 517 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL 576 + ++ + +E + +L +A GE ESE ++A E Sbjct: 2159 PESEGIEAQ----EAEEEAQPELEGVEAPEAEGEAQPESEG-IEAPE------------- 2200 Query: 577 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYK 636 AE Q L + +E + +E E E E+EG + K Sbjct: 2201 -------AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE----GEAQPESEGETQGEK 2249 Query: 637 KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIAS 696 K ++ + D + + S + + + S G TP S + +S Sbjct: 2250 KGSPQV---------SLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSS 2300 Query: 697 RKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDA--KKAKQEPEVNGGSGDAVPSGNE 754 + + + ++ H++ R P+ +S A K + PE + + P G+ Sbjct: 2301 SRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSR 2360 Query: 755 VSENMEEEAENQAESRA 771 E E + E +A Sbjct: 2361 TPEQGASEGYDLQEDQA 2377 Score = 42.7 bits (99), Expect = 0.001 Identities = 56/259 (21%), Positives = 109/259 (42%), Gaps = 39/259 (15%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 176 E+E E+ +E +N +++ A ++E+V + EE K+ + + E + +++ Sbjct: 1273 EDEAERDSEEQRASSN--LEQLAENTVQEEV-----QLEETKEGTEGEGLQEEAVQLEET 1325 Query: 177 EMEKGGRED---MDISKSAE-EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232 + E+G +E+ ++ +K E E Q++ + L+ + ET E G EG EV G Sbjct: 1326 KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE---GLQEEGVQLEEVKEG-- 1380 Query: 233 EQEVPDAEEEKSVSGTDVQEECREKGGQEK---QGEVIVSIEEKPKEVSEEQPVVTLEKQ 289 E + G ++E +E+G E+ G+ + + S+E V E+ Sbjct: 1381 --------PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEA 1432 Query: 290 GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 349 G A + +P G E + + +E + E+ G ++ P E P T Sbjct: 1433 GRA--------SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484 Query: 350 ----EAAEASAVEAGSEVS 364 E +A + +E S Sbjct: 1485 MMGQEHTQAQPTQGAAERS 1503 Score = 42.4 bits (98), Expect = 0.002 Identities = 45/198 (22%), Positives = 79/198 (39%), Gaps = 22/198 (11%) Query: 97 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156 E ++E G EG+ E + E+T+ E ++ EE +E E + + EE Sbjct: 1299 EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEE 1358 Query: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGG 216 ++T + L + E+ E +GG + ++ EE L E +G Sbjct: 1359 IEETGGEGLQEEGVQLEEVKEGPEGGLQ----GEALEE----------GLKEEGLPEEGS 1404 Query: 217 AAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKE 276 + +EA GK QE +EE++ + E C +G +E E P Sbjct: 1405 VHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP--------TEPPSH 1456 Query: 277 VSEEQPVVTLEKQGTAVE 294 +SE P + + G+ +E Sbjct: 1457 LSETDPSASERQSGSQLE 1474 Score = 40.4 bits (93), Expect = 0.006 Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 14/124 (11%) Query: 399 ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV--------DTKVAQGATEK 450 ER +E + S E++ V QEE +L + G+G+ +TK +G E+ Sbjct: 1277 ERDSEEQRASSNLEQLAENTV--QEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEE 1334 Query: 451 SPE-DKVQIAANEETQEREEQMKEGEET--EGSEEDDKENDKTEEMPNDSVLENKSLQEN 507 + ++ + E QE E Q++E EET EG +E+ + ++ +E P + L+ ++L+E Sbjct: 1335 GVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP-EGGLQGEALEEG 1393 Query: 508 EEEE 511 +EE Sbjct: 1394 LKEE 1397 >gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] Length = 793 Score = 75.5 bits (184), Expect = 2e-13 Identities = 124/567 (21%), Positives = 229/567 (40%), Gaps = 54/567 (9%) Query: 115 VEEEEGEKTEDESLVENNDN---IDEEAREELREQ--VYDAMGEKEEAKKT-EDKSLAKP 168 V +EE + T + VE +D ++ AR E R Q + +A+ ++E T D SL+ P Sbjct: 74 VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP 133 Query: 169 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 228 + D+ E + + +E QE+ ++ TET VT Sbjct: 134 SRRMQNDT----AENETTEKEEKSESRQERYEIEE---TET-----------------VT 169 Query: 229 SGKPEQEVPDAEEEKSVSGT-DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287 + + DAEE K + +EE + K G + +V V +EEK E EE V++L+ Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229 Query: 288 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEV 347 + E + + ++ E E+ EA +A LE + + AE+ ++ Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKKI 288 Query: 348 TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG 407 E A A E + E+ +EA + + Q E + +R E + Sbjct: 289 ADERARIEAEEKAA-AQERERREAEERERMREEEKRAAEERQRIKEEE---KRAAEERQR 344 Query: 408 SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQER 467 EEK A +E ++ EE AA + + + K E K E+ Sbjct: 345 IKEEEKRAA-----EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399 Query: 468 EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 527 +E +GE+ E E N+K + + L+ L++ EE+ ++ + L K Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQ---EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456 Query: 528 IFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETH 587 FK++E K+ ++ K E E ++++ + F + +++ + T Sbjct: 457 TFKKEEIKDEKIK------KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 510 Query: 588 YQLGLAYGYNSQYDEAVAQFS--KSIEVIENRMAVL-NEQVKEAEGSSAEYKKEIEELKE 644 + G +++ E Q K +E + R +E+ ++ + E E+EELK+ Sbjct: 511 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 570 Query: 645 LLPEIREKIEDAKESQRSGNVAELALK 671 E R K+ + +E +R A+ L+ Sbjct: 571 KREE-RRKVLEEEEQRRKQEEADRKLR 596 Score = 56.6 bits (135), Expect = 9e-08 Identities = 94/428 (21%), Positives = 173/428 (40%), Gaps = 77/428 (17%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELR-EQVYDAMGEKEEAKKTEDKSL--------- 165 +EEE E+ DE + +++ ++EE +E E+ E+E K +DK + Sbjct: 240 QEEEREQGSDE--ISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297 Query: 166 ----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG 221 A E ++ + E E+ E+ ++ + +E+ + EE K A Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357 Query: 222 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEK---------QGEVIVS--- 269 + E E++ AEEE+ V+E+ R K +EK +GE + Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAK---VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414 Query: 270 ---IEEKPKEVSEEQPVVTL---EKQGTAVEVEAESLD---PTVKPVDVGGD------EP 314 + EK + + Q V E++GT V+ + E L PT K ++ + EP Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474 Query: 315 EEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVL 374 +E+V K+ +++ G ++ +T + ++ +PG A V Sbjct: 475 KEEV--------KSFMDRKKGFTEVKSQNGEFMTHK------LKHTENTFSRPGGRASVD 520 Query: 375 PKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEA 434 K+ A P V E +E L + + EE KL Q+E L +EE + Sbjct: 521 TKE-AEGAPQV-------EAGKRLEELRRRRGETESEE--FEKLKQKQQEAALELEELKK 570 Query: 435 AGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494 + + E+ + + Q A+ + +E EE+ + EE E + E K ++MP Sbjct: 571 -----KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE--KRQKMP 623 Query: 495 NDSVLENK 502 D + ++K Sbjct: 624 EDGLSDDK 631 Score = 49.3 bits (116), Expect = 1e-05 Identities = 70/309 (22%), Positives = 126/309 (40%), Gaps = 45/309 (14%) Query: 386 VGDQTPIEPQTSIE------RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV 439 V DQ + Q S+ T T+ E +L +E + ++E+ Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121 Query: 440 DTKVAQGATEKSPEDKVQIAANEETQEREEQMK------EGEETEGSEEDDKENDKTEEM 493 D + + A ET E+EE+ + E EETE + ++ND + Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181 Query: 494 PNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSV 553 N E+K +E EEE+ + + ++ + ++T E+Q LK G++S Sbjct: 182 ENKK--EDKEKEEEEEEKPKRGSIGENQVE----VMVEEKTTESQEETVVMSLKNGQISS 235 Query: 554 E----SENYVQAVEEFQSCLNLQEQYLEAHD----RLLAETHYQLGLAYGYNSQYDEAVA 605 E E Q +E ++E+ E + RL AE ++ ++ D+ +A Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI------KAEQDKKIA 289 Query: 606 QFSKSIEV--------IENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED-- 655 IE E R A E+++E E +AE ++ I+E ++ E R++I++ Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349 Query: 656 ---AKESQR 661 A+E QR Sbjct: 350 KRAAEERQR 358 Score = 45.1 bits (105), Expect = 3e-04 Identities = 68/320 (21%), Positives = 124/320 (38%), Gaps = 32/320 (10%) Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDL 524 Q+REE E E DD E + E + E + Q+ EEE +G + D Sbjct: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE-RLRQKQEEESLG------QVTDQ 65 Query: 525 AKIIFKRQ-ETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLL 583 ++ + +EA+ ++ + + E + E Q L + + D + Sbjct: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 125 Query: 584 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK-EIEEL 642 + L Q D A + ++ E E+R +++E E + Y+K + + Sbjct: 126 TDASLSLP---SRRMQNDTAENETTEKEEKSESRQE--RYEIEETETVTKSYQKNDWRDA 180 Query: 643 KELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS-SVSMIASRKPTD 701 +E E +EK E+ +E + G++ E ++ + E +T S I+S +P Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240 Query: 702 GASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEE 761 +ISH K EEE + +A++A+ E E E E Sbjct: 241 EEEREQGSDEISH----HEKMEEEDKERAEAERARLEAE-------------ERERIKAE 283 Query: 762 EAENQAESRAAVEGTVEAGA 781 + + A+ RA +E +A A Sbjct: 284 QDKKIADERARIEAEEKAAA 303 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 73.6 bits (179), Expect = 7e-13 Identities = 102/427 (23%), Positives = 169/427 (39%), Gaps = 49/427 (11%) Query: 111 EGVHVEE--EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168 E V VEE EE + TE+ + E + +EE +EE GE+EEA+ E+++ + P Sbjct: 453 ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE-------EGGEEEEAEGGEEETKSPP 505 Query: 169 -ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEA-- 225 E + E + +E+ A+ P++ EEAK A + P +A Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEK-------------EEAKSPAEVKSPEKAKS 552 Query: 226 ---EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP 282 E PE + P+ EE KS + E+ + +E + EK K +E+ Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612 Query: 283 VVTLEKQGTAVE-----VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQE 337 E + E E +S + P P EK + E E K+ + Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP-EKAKSPEKEEAKS--PEKAKSP 669 Query: 338 VPPAEESPEVTTEAAEASA---VEAGSEVSE--KPGQEAPVLPKDGA-----VNGPSVVG 387 V +SPE +A A +A S V E K ++A K+ A P Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729 Query: 388 DQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGA 447 +TP + ++ ++ ++ + + EK + V S E + EE+ + D K Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV 789 Query: 448 TE--KSPED-KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 504 E KSPE K + + + E+E KE ++ EE+ + K +E P + E Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA 849 Query: 505 QENEEEE 511 EE+ Sbjct: 850 TPKTEEK 856 Score = 69.7 bits (169), Expect = 1e-11 Identities = 135/659 (20%), Positives = 237/659 (35%), Gaps = 116/659 (17%) Query: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180 EK+E E+++ + + EE+ E+ E++EAK+ E K ++E E E Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEE------EEKEAKEEEGK-------EEEGGEEEEA 494 Query: 181 GGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVP 237 G E+ S AEE P+++ + EEAK A + P + E K EV Sbjct: 495 EGGEEETKSPPAEEAASPEKEAK------SPVKEEAKSPAEAKSPEKEEA---KSPAEVK 545 Query: 238 DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 297 E+ KS + + + K ++++ + P EV + + K+ EA Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAK-------SPAEVKSPEKAKSPAKEEAKSPAEA 598 Query: 298 ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 357 +S + PV P E + EA EV E++ T E A++ Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA-------EVKSPEKAKSPTKEEAKSPEK 651 Query: 358 EAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAK 417 E E E P P E ++ + + K+ + EK ++ Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711 Query: 418 L---VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474 + S E+ K V+E + + V + A KSPE A + E + + Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA--KSPEK----AKSPEKAKTLDVKSPE 765 Query: 475 EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 534 +T EE DK E V E E + E L D K I K++E Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKE-----EVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820 Query: 535 KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAY 594 K V+ E Q V+ + +E+ A + + Sbjct: 821 KSP---------------VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK-------- 857 Query: 595 GYNSQYDEAVAQFSKSIEVIENRMAVLN---EQVKEAEGSSAEYKKEIEELKELLPEIRE 651 +S+ +EA + + +V E + + E EA+ AE KK++ ++ P E Sbjct: 858 --DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915 Query: 652 KIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTD 711 EDAK ++ + +A ++P D + Sbjct: 916 VKEDAKPKEK------------------------------TEVAKKEPDDAKAKE----P 941 Query: 712 ISHLVRKKRKPEEESPRKDDAKKAKQEPEVNG-GSGDAVPSGNEVSENMEEEAENQAES 769 +K+ PE++ +++ AKK +++P+ D E S+ E+AE + + Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000 Score = 67.4 bits (163), Expect = 5e-11 Identities = 94/415 (22%), Positives = 172/415 (41%), Gaps = 33/415 (7%) Query: 119 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM 178 E E+ + + V++ + A+EE + EKEEAK + + PE K E Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE--VKSPEKAKSPAKEE 591 Query: 179 EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS---GKPEQE 235 K E K+ +E+ + + EEAK A + P +A+ + K ++ Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651 Query: 236 VPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE---EQPVVTLEKQGTA 292 E+E++ S + + + ++ + V E K E ++ ++ + EK + Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711 Query: 293 VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 352 V+ EA+S + PV PE+ + EA + + +SPE T A Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771 Query: 353 EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE-----PQTSIERLTETKDG 407 E EA S + P E P V P ++P++ P+ I + E K Sbjct: 772 E----EARSPADKFP--EKAKSPVKEEVKSPEKA--KSPLKEDAKAPEKEIPKKEEVK-- 821 Query: 408 SGLEEKVRAKLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQIAANEE 463 S ++E+ + + V +E K + EE A + D+K + +++P+ KV+ E+ Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE----EK 877 Query: 464 TQEREEQMKEGE-ETEGSEEDDKENDKTEEMPNDSVLENK-SLQENEEEEIGNLE 516 + E+ KE + E + E +DK+ T E + +E K + E+ E+ E Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932 Score = 62.4 bits (150), Expect = 2e-09 Identities = 92/409 (22%), Positives = 159/409 (38%), Gaps = 46/409 (11%) Query: 122 KTEDESLVENNDNIDEEAR--------EELREQVYDAMGEKEEAKKTEDKSLAKPETDKE 173 K E +S E + EEA+ E+ + + E+AK E + PE K Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668 Query: 174 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG-KP 232 K + K+ + EK + ++ E+AK E + + S K Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728 Query: 233 EQEVPDAEE----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288 E + P+ + E++ S + + K K E +E+ + +++ P EK Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP----EK 784 Query: 289 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP---PAEESP 345 + V+ E +S + P+ PE+++ E E V E+ QEV P +++ Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEKPQEVKVKEPPKKAE 843 Query: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLP----KDGAVNGPSVVGDQTPIE-------- 393 E A + + S+ E P +EAP K+ AV P + E Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903 Query: 394 --PQTSIERLTETKDGSGLEEKVR-AKLVPSQEETK---LSVEESEAAGDGVDTKVAQGA 447 P+ E K+ + +EK AK P + K E+ EAA + DTK + Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA- 962 Query: 448 TEKSPEDKVQIAA----NEETQEREEQMKEGEETEGSEEDDKENDKTEE 492 K PE+K + A +++T +E + E+ E S D+++ K E Sbjct: 963 --KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009 Score = 44.7 bits (104), Expect = 3e-04 Identities = 54/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE--DKSLAKPETDKE 173 EE + E+E E + EE + EK+++KK E K KP+ +++ Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877 Query: 174 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 233 ++ +EK ++ K E ++KV T + E K A P+ + EV +P+ Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVP-TPEKEAPAKVEVKEDAKPK--EKTEVAKKEPD 934 Query: 234 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK-EVSEEQPVVTLEKQGTA 292 DA+ ++ + +E EK ++ + E EEKPK E ++ TL K+ + Sbjct: 935 ----DAKAKEPSKPAEKKEAAPEK--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK 988 Query: 293 VEVE-AESLDPTVKPVDVGGDEPEEKVVTSENEAGK 327 + E AE T D +P EK + GK Sbjct: 989 PKAEKAEKSSST----DQKDSKPPEKATEDKAAKGK 1020 Score = 39.3 bits (90), Expect = 0.014 Identities = 94/427 (22%), Positives = 158/427 (37%), Gaps = 94/427 (22%) Query: 403 ETKDG------SGLEEKVRAKLVPSQEETKLSVEE---------SEAAGDGVDTKVAQGA 447 ET+D S L E +RA+L ++ L EE SEAA V+T + A Sbjct: 258 ETRDALKCDVTSALRE-IRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAK--VNTDAMRSA 314 Query: 448 TEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPN-----DSVLENK 502 E+ E + Q+ A E + K+ E + SE +D+ D+ L N Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374 Query: 503 ----SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE-------- 550 + Q E +++ N+++A D+ A K E +E ++ L E Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAA--YRKLLEGEECRIGFGPIPFSLPEGLPKIPSV 432 Query: 551 ---VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQF 607 + V+SE ++ VE+ + + E+ E +Q E V + Sbjct: 433 STHIKVKSEEKIKVVEKSEKETVIVEEQTE-------------------ETQVTEEVTE- 472 Query: 608 SKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAE 667 E E+ KE EG E + EE + P E KE+ Sbjct: 473 -------EEEKEAKEEEGKEEEGGEEEEAEGGEE-ETKSPPAEEAASPEKEA-------- 516 Query: 668 LALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESP 727 K+ + E + S S ++ P + S + K PE +SP Sbjct: 517 ---KSPVKEEAKSP----AEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPPEAKSP 567 Query: 728 RKDDAK---------KAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 778 K++AK KAK + S S + ++EEA++ AE+++ V+ + Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627 Query: 779 AGATVES 785 + A V+S Sbjct: 628 SPAEVKS 634 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 73.2 bits (178), Expect = 9e-13 Identities = 99/419 (23%), Positives = 180/419 (42%), Gaps = 50/419 (11%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 176 +++ +K + +E+ N D++A +++ +KE +K D+ AK KE++ Sbjct: 200 QKKNQKNKPGPNIESG-NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE- 257 Query: 177 EMEKGGREDMDISKSA---EEPQEKVDLTLDW--LTETSEEAKGGAAPEGPNEAEVTSGK 231 E+E G ++ +S EE K +T+D + + E+A+ A E NE + K Sbjct: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK-K 316 Query: 232 PEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291 +++ +EEK + K QE ++ EE+ ++ EE+ + ++ Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK---EEEERQKREEEERIKRLEELE 373 Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ--LVGQEVPPAEESPEVTT 349 A E E L+ E E+ E E + + ++ L+ + A E T Sbjct: 374 AKRKEEERLE----------QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423 Query: 350 EAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG 409 + +A VE S+ S LPK + + I Q + ++E+ + Sbjct: 424 KLLQAQGVEVPSKDS---------LPKKRPIYEDK---KRKKIPQQLESKEVSESMELCA 471 Query: 410 LEEKVRAKLVPSQEETKLSVE-----ESEAAG-DGVDTKVAQGATEKSPEDKVQIAANEE 463 E V + VP +EET VE ++E AG D + + TEK +KV I E Sbjct: 472 AVE-VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN 530 Query: 464 TQEREEQMKEGEETEGSEEDDK--------ENDKTEEMPNDSVLENKSLQENEEEEIGN 514 +E EE+ +E EE E SEE+++ E D+ +E +D K+L + +E+ + Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS 589 Score = 53.1 bits (126), Expect = 1e-06 Identities = 60/261 (22%), Positives = 115/261 (44%), Gaps = 33/261 (12%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175 EEEE +K E+E ++ + ++ + +EE R + EK E KK + +KE+ Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLE-----QEKRERKK---------QKEKERK 398 Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG---PNEAEVTSGKP 232 ++K G+ ++KS E + + + TL L +A+G P P + + K Sbjct: 399 ERLKKEGKL---LTKSQREARARAEATLKLL-----QAQGVEVPSKDSLPKKRPIYEDKK 450 Query: 233 EQEVPDAEEEKSVSGT---DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 289 +++P E K VS + E E+G EK+ E +E + +E +E+ + E Sbjct: 451 RKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE-ETPPPVEPEEEEDTEDAGLDDWE-- 507 Query: 290 GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 349 A + E E ++ ++V + EE+ E E + E+ + E E Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567 Query: 350 EAAEASAVEAGSEVSEKPGQE 370 + ++ ++G + +KP +E Sbjct: 568 KVSDEK--DSGKTLDKKPSKE 586 Score = 51.2 bits (121), Expect = 4e-06 Identities = 118/572 (20%), Positives = 224/572 (39%), Gaps = 56/572 (9%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE---TDK 172 ++ +G+K +++ + D +++ +EL E +A G K + + K E T K Sbjct: 38 QKSKGKKKKEK---KKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSK 94 Query: 173 EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNE-AEVTSGK 231 ++ + +KG ++ D +EE ++K + E G + N+ + GK Sbjct: 95 DKKKKGQKGKKQSFD-DNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGK 153 Query: 232 PEQEVP--DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 289 ++ D EE + ++E R E E ++ + + ++ K Sbjct: 154 AQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK-----NKP 208 Query: 290 GTAVEVEAESLDPTVKPVDVGGDEPEEKV-VTSENEAGKAVLEQLVGQEVPPAEESPEVT 348 G +E E D + K V + E+K + + KA L +L +E E+ Sbjct: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL--------KEKEELE 260 Query: 349 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD-- 406 T + S + E+ ++ V G + S +TP + E + KD Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPA-SEEKAETPTAAEDDNEGDKKKKDKK 319 Query: 407 --GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET 464 EEK + K + T +++E+ A K + ++ E++++ E Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALA-----KLKEEEERQKREEEERIKRLEELEA 374 Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL------- 517 + +EE+ E E+ E ++ KE ++ E + + L KS +E L+L Sbjct: 375 KRKEEERLEQEKRERKKQ--KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432 Query: 518 --AWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQY 575 + D L + I++ ++ K+ L+ EVS ES AVE + + +E+ Sbjct: 433 VPSKDSLPKKRPIYEDKKRKK-----IPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486 Query: 576 LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKS---IEVIENRMAVLNEQVKEAEGSS 632 + E GL DE + + IEV EN E+ +E E Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546 Query: 633 AEYKKEIEELKELL--PEIREKIEDAKESQRS 662 +E ++E E E E EK+ D K+S ++ Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578 Score = 48.5 bits (114), Expect = 2e-05 Identities = 118/616 (19%), Positives = 240/616 (38%), Gaps = 86/616 (13%) Query: 190 KSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249 K+ E K D+ LD L E A GAA E + K E++ D +E+ + + Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGA--GAAKEQEPQKSKGKKKKEKKKQDFDEDDILK--E 61 Query: 250 VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDP------- 302 ++E E G + E + KP E +EE+ + +K+ + + +S D Sbjct: 62 LEELSLEAQGIKADRETVAV---KPTENNEEE-FTSKDKKKKGQKGKKQSFDDNDSEELE 117 Query: 303 --------TVKP---VDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351 T KP + G D+ ++ + GKA Q ++ +EE + + + Sbjct: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA---QKSNKKWDGSEEDEDNSKKI 174 Query: 352 AEASAV----EAGSEVSE----KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTE 403 E S + E+G E E + GQ+ K G P++ + I+ + + Sbjct: 175 KERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG----PNIESGNEDDDASFKIKTVAQ 230 Query: 404 TKDGSGLEEKVRAKLVPSQEETKL-SVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANE 462 K E+K R + +E+ KL ++E E ++ G ++S + + Q E Sbjct: 231 KK----AEKKERERKKRDEEKAKLRKLKEKE--------ELETGKKDQSKQKESQRKFEE 278 Query: 463 ETQEREEQMKEG--------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 514 ET + + + G ET + EDD E DK ++ + K +E +E+E Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKK----KKKGEKEEKEKEKKK 334 Query: 515 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHLK-LGEVSVESENYVQAVEEFQSCLNLQE 573 + + + + K +E +E Q + +K L E+ + + + +E + +E Sbjct: 335 GPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE 394 Query: 574 ----QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAE 629 + L+ +LL ++ + + +A S + + + + ++ ++ Sbjct: 395 KERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKI 454 Query: 630 GSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS 689 E KE+ E EL + + E + + VE T G Sbjct: 455 PQQLE-SKEVSESMELCAAVEVMEQGVPEKEET---------PPPVEPEEEEDTEDAGLD 504 Query: 690 SVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAV 749 +AS + T+ + ++ ++ + EEE +++++ ++E + GS Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGS---- 560 Query: 750 PSGNEVSENMEEEAEN 765 G+E E + +E ++ Sbjct: 561 -EGDEEDEKVSDEKDS 575 Score = 42.0 bits (97), Expect = 0.002 Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 1/82 (1%) Query: 113 VHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDK 172 VH+E +E + E+E E ++ + E EE + + G++E+ K +++K K DK Sbjct: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK-TLDK 581 Query: 173 EQDSEMEKGGREDMDISKSAEE 194 + EM D D ++ EE Sbjct: 582 KPSKEMSSDSEYDSDDDRTKEE 603 Score = 40.0 bits (92), Expect = 0.008 Identities = 73/397 (18%), Positives = 157/397 (39%), Gaps = 16/397 (4%) Query: 272 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG-KAVL 330 +K K SE+ ++ A E+E +P G + +EK +E L Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62 Query: 331 EQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQT 390 E+L + + V + E + E S+ +K GQ+ D N + D+ Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDD--NDSEELEDKD 120 Query: 391 PIEPQTSIERLT------ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVA 444 +T+ ++ + D + L +K + K S ++ S EE E + + Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGS-EEDEDNSKKIKERSR 179 Query: 445 QGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 504 ++ +S ++ + + + Q++ ++ K G E EDD + K + + + + Sbjct: 180 INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE 239 Query: 505 QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 564 ++ +EE L + +L + + KE+Q + +K +V+V++ + A EE Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVK-SKVTVDT-GVIPASEE 297 Query: 565 FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ 624 E E D+ + + G + ++ +++ ++ +A L E+ Sbjct: 298 KAETPTAAEDDNEG-DKKKKDKKKKKG--EKEEKEKEKKKGPSKATVKAMQEALAKLKEE 354 Query: 625 VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 661 + + E K +EEL+ E E++E K ++ Sbjct: 355 EERQKREEEERIKRLEELEAKRKE-EERLEQEKRERK 390 Score = 36.2 bits (82), Expect = 0.12 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 6/95 (6%) Query: 101 MENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELR------EQVYDAMGEK 154 ME GV VE EE E TED L + +E E++ E + E+ Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535 Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDIS 189 EE ++ E+ ++ E ++E +SE +G ED +S Sbjct: 536 EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570 Score = 36.2 bits (82), Expect = 0.12 Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 2/82 (2%) Query: 117 EEEGEKTEDESL-VENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175 +EE EK E + +E +N +EE EE E+ D E+EE ++ E + E D++ Sbjct: 512 DEETEKVEGNKVHIEVKENPEEEEEEE-EEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570 Query: 176 SEMEKGGREDMDISKSAEEPQE 197 E + G D SK E Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSE 592 >gi|153945728 microtubule-associated protein 1B [Homo sapiens] Length = 2468 Score = 72.4 bits (176), Expect = 2e-12 Identities = 94/417 (22%), Positives = 175/417 (41%), Gaps = 53/417 (12%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSL----- 165 E V V++++ KTE + V + +E ++ +V + + K ++K++ Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643 Query: 166 AKPETDKEQDSEMEK--GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN 223 KPE KE+ + +K +ED K E+P+++ E +E K E Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKE---------EVKKEVKKEIKKEEKK 694 Query: 224 EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 283 E P++EV K V +EE +E +EK+ + I++ PK+ + Sbjct: 695 E-------PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK--KEIKKLPKDAKKSSTP 745 Query: 284 VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEE----KVVTSENEAGKAVLEQLVGQEVP 339 ++ K+ A++ + + +VK V +P+E KV+ E +A +AV + Sbjct: 746 LSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATT 805 Query: 340 PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI- 398 A + A +EA + P L KD V I+PQ + Sbjct: 806 AAVMAAAGIAAIGPAKELEAERSLMSSPED----LTKDFEELKAEEVDVTKDIKPQLELI 861 Query: 399 ---ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK 455 E+L ET E V A ++ Q+E +++ +E+ +G+ T +G E++PE+ Sbjct: 862 EDEEKLKET-------EPVEAYVI--QKEREVTKGPAESPDEGITTTEGEGECEQTPEEL 912 Query: 456 VQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 + E Q ++ K +E G EE + D E+ + E + +E+ EE + Sbjct: 913 EPV----EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE---EAEEPEEDGEEHV 962 Score = 67.0 bits (162), Expect = 6e-11 Identities = 90/407 (22%), Positives = 175/407 (42%), Gaps = 43/407 (10%) Query: 117 EEEGEKTEDESLVENNDNID-EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175 ++E K ED++ ++ + EE ++E+++++ K+E KK K + K KE Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI------KKEEKKEPKKEVKKETPPKEVK 710 Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP--EGPNEAEVTSGKPE 233 E++K E ++ K +EP++++ + ++AK + P E A + P+ Sbjct: 711 KEVKK--EEKKEVKKEEKEPKKEIK-------KLPKDAKKSSTPLSEAKKPAALKPKVPK 761 Query: 234 QEVPDAEEEKSVSGTDVQEECREK--GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291 +E ++ ++ SV+ +E+ + K + K E + + + + G Sbjct: 762 KE--ESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819 Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351 A E+EAE P D+ D E K E + K + QL E +E TE Sbjct: 820 AKELEAER-SLMSSPEDLTKDFEELKA--EEVDVTKDIKPQLELIE----DEEKLKETEP 872 Query: 352 AEASAVEAGSEVSEKPGQ--EAPVLPKDGAVNGPSVVGDQTPIEPQ--TSIERLTETKDG 407 EA ++ EV++ P + + + +G + P+E Q IE+ + +G Sbjct: 873 VEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFED--EG 930 Query: 408 SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---EDKVQIAANEET 464 +G EE E K EE+E + + V A++ SP E+ + A+ Sbjct: 931 AGFEESSET----GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986 Query: 465 QEREEQMKEGEETEGSEEDDK-ENDKTEEMPNDSVLENKSLQENEEE 510 +E+ E + G++ + D+ E + E+ ++ E+K+ EEE Sbjct: 987 REKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033 Score = 54.3 bits (129), Expect = 4e-07 Identities = 102/424 (24%), Positives = 172/424 (40%), Gaps = 59/424 (13%) Query: 142 ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR-EDMDISKSAEEPQEKVD 200 +L+++ K AK KS+ K KE+ E+ K E +S E+ K D Sbjct: 534 KLKQRADSRESLKPAAKPLPSKSVRKES--KEETPEVTKVNHVEKPPKVESKEKVMVKKD 591 Query: 201 LTLDWLTETSEEAKGGAAPEGPN--EAEVTSGKPEQEVPDAEEEKSVS-----GTDVQEE 253 + T+ S K + E P+ +AEV + P A +EK+V + ++E Sbjct: 592 KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKE 651 Query: 254 CREKGGQE---KQGEVIVSIEEKPK--EVSEE-----------QPVVTLEKQGTAVEVEA 297 +EK +E K+ + + EEKPK EV +E +P ++K+ EV+ Sbjct: 652 EKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKK 711 Query: 298 ESLDPTVKPVDVGGDEPEEKVVTSENEAGK-------AVLEQLVGQEVPPAEESPEVTTE 350 E K V EP++++ +A K A + +VP EES + + Sbjct: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV 771 Query: 351 AAEASAVEAGSEVSEKPGQEAPVLPK---DGAVN-------GPSVVGDQTPIEPQTSIER 400 AA + +V +K G+ A + GA G + +G +E + S+ Sbjct: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831 Query: 401 LTE--TKDGSGLEE---------KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 449 E TKD L+ K + +L+ +E+ K E EA + +V +G E Sbjct: 832 SPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLK-ETEPVEAYVIQKEREVTKGPAE 890 Query: 450 KSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK---TEEMPNDSVLENKSLQE 506 SP++ + E E+ + E E +G ++ +K D+ EE E K+ E Sbjct: 891 -SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949 Query: 507 NEEE 510 EE Sbjct: 950 EAEE 953 Score = 44.3 bits (103), Expect = 4e-04 Identities = 98/430 (22%), Positives = 160/430 (37%), Gaps = 85/430 (19%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170 EG+ E EGE E E + ++++ +++ E+ D EE+ +T D K ET Sbjct: 894 EGITTTEGEGEC---EQTPEELEPVEKQGVDDI-EKFEDEGAGFEESSETGDYE-EKAET 948 Query: 171 DKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLD-WLTETSEEAKGG--AAPEGPNE 224 E+ E E+ G E + +S S P +E D ++ E E G A E +E Sbjct: 949 --EEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDE 1006 Query: 225 AEVTSGKPEQEVPDAEEEKSVSGTDVQE-----------------ECREKGGQEKQ-GEV 266 A + G+ EQ +A+EE +E + E GG E+Q G + Sbjct: 1007 A-IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFL 1065 Query: 267 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326 ++ + +P ++ + E+E+ T + D+PEE TS G Sbjct: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEA---TASDEENREDQPEEFTATS----G 1118 Query: 327 KAVLEQLVGQEVPPAEE--------SPEVTTEAAEASAVE-------AGSEVSEKPGQEA 371 + E P +E S E E E+ + E S S++ + A Sbjct: 1119 YTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178 Query: 372 PVLPKDG--------AVNGPSVVGDQTPIEPQTSIER------------LTETKDGSGLE 411 V P +G A +G + I P +S+E +E K + L+ Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238 Query: 412 ----------EKVRAKLVPSQEETKLSVEESEAAGD-GVDTKVAQGATEKSPEDKVQIAA 460 EKV PS + S E G+ V+ + + S E +V + Sbjct: 1239 IKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVS 1298 Query: 461 NEETQEREEQ 470 E TQE E+ Sbjct: 1299 PEVTQEVVEE 1308 Score = 41.6 bits (96), Expect = 0.003 Identities = 35/110 (31%), Positives = 52/110 (47%), Gaps = 9/110 (8%) Query: 411 EEKVRAKL-VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREE 469 +EKV K P + ETK SV E E + V EK D AA E+T ++E Sbjct: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642 Query: 470 QMKEGEETEGSEEDDKE----NDKT----EEMPNDSVLENKSLQENEEEE 511 ++K ++ E E+ KE DKT EE P ++ + +E ++EE Sbjct: 643 KVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEE 692 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 71.6 bits (174), Expect = 3e-12 Identities = 121/557 (21%), Positives = 225/557 (40%), Gaps = 49/557 (8%) Query: 118 EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETD-KEQDS 176 +E E E E + + E LREQ M E+EE ++K L + E + +EQ+ Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMWRQEKRLREQEKELREQEK 335 Query: 177 EMEKGGREDMDISKSAEEPQEKVDLTLDWLTE---TSEEAKGGAAPEGPNEAEVTSGKPE 233 E+ RE ++ + E+ QE+ + W E +E K E E E + E Sbjct: 336 EL----REQKELREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389 Query: 234 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293 Q++ D EE + E REK + ++ E + EK +E + Q Sbjct: 390 QKMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKMREEKKMQ------------ 433 Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353 E E ++ D K + EK + E E + E++ QE E+ + + Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493 Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEE 412 E E + QE + ++ + + Q + E++ E +D EE Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE--KKMWRQEKMREQEDQMWEQEE 551 Query: 413 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 472 K+R QE+ EE K Q +K+ + + ++ E +ERE++M+ Sbjct: 552 KMR-----DQEQKMWDQEERM-------EKKTQEQEKKTWDQEEKMREEERMREREKKMR 599 Query: 473 EGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFK 530 E EE E E+ ++ +K +E + + +QE EE+ E W+ + +++ Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ---EEKMWE 656 Query: 531 RQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQL 590 +Q E Q H K+ E E + E+ + QEQ + D+ + Sbjct: 657 QQRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715 Query: 591 GLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIR 650 + +E + + + ++ E +M E++ E E E ++++ E ++ LPE + Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE-QQRLPEQK 774 Query: 651 EKIEDAKESQRSGNVAE 667 EK+ + ++ Q + E Sbjct: 775 EKLWEHEKMQEQEKIWE 791 Score = 46.2 bits (108), Expect = 1e-04 Identities = 79/408 (19%), Positives = 168/408 (41%), Gaps = 73/408 (17%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELRE--QVYDAMGEKEEAKKTEDKSLAKPETDKE 173 E+EE + +++ + + + ++++ +E+ ++ + M E+E ++ E K + E +E Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607 Query: 174 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 233 Q+ +M++ + + + E +EK+ +E K E E E + + Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQ---------EQEEKMWEQEEKMWEQEEKMWE-Q 657 Query: 234 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293 Q +P+ ++EK +QE+ + + +EK E +EK ++ ++EQ T +++ Sbjct: 658 QRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWE-----QEKMEKKTQEQEKKTWDQEKMR- 710 Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353 E ES+ EK + E E + E++ QE E+ E+ + Sbjct: 711 --EEESM------------REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE-- 754 Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413 E E EK ++ +RL E K+ EK Sbjct: 755 ----EKMWEQEEKMWEQ----------------------------QRLPEQKEKLWEHEK 782 Query: 414 VRAKLVPSQEETKLSVEESEAAGD-----GVDTKVAQGATEKSPEDKVQIAANEETQERE 468 ++ + ++E K+ +E + G G + K+ +G EK + ++ EE + Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM-RGQEEKMWGQEEKMWGQEEKMWGQ 841 Query: 469 EQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516 E+ G+E + E+ + +K E + + ++E EE+ G E Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889 Score = 42.7 bits (99), Expect = 0.001 Identities = 80/366 (21%), Positives = 140/366 (38%), Gaps = 64/366 (17%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170 E + E E + E+E ++ + +E E+++EQ ++E+ ++ E+K + E Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646 Query: 171 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 230 EQ+ +M + R E +EK+ W E +E + Sbjct: 647 MWEQEEKMWEQQR--------LPEQKEKL-----WEHEKMQEQE---------------K 678 Query: 231 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQG 290 EQE E+EK T QE+ ++ QEK E S+ E+ K++ EE+ + + +Q Sbjct: 679 MQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREE-ESMREREKKMREEEEM--MREQE 733 Query: 291 TAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE 350 ++ + E + E EE++ E + + + Q +P E E E Sbjct: 734 EKMQEQEEKM-----------QEQEEEMWEQEEKMWEQEEKMWEQQRLP---EQKEKLWE 779 Query: 351 AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 410 + E E EK + + G + + Q R E K G Sbjct: 780 HEKMQEQEKIWEQEEKMRDQE-----------EKMRGQEEKMRGQEEKMRGQEEKMW-GQ 827 Query: 411 EEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQ 470 EEK+ QEE EE + + QG EK E + ++ EE +E+ Sbjct: 828 EEKMW-----GQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882 Query: 471 MKEGEE 476 G+E Sbjct: 883 KMRGQE 888 Score = 42.4 bits (98), Expect = 0.002 Identities = 66/312 (21%), Positives = 129/312 (41%), Gaps = 52/312 (16%) Query: 398 IERLTETKDGSGLE--------EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 449 IE LT+ +D LE E+++ K QE KL + ESE + ++ K + E Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQE--KLPLAESEKSEIQLNVKELKRKLE 256 Query: 450 KSPEDKVQIAAN---EETQEREEQMKEGE------------------ETEGS--EEDDK- 485 ++ Q+ N EE +EE+++E E E EG E+++K Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316 Query: 486 --------ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA 537 E +K + E K L+E EE+ E W+ + + ++ +E Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376 Query: 538 QLYAAQAHLKLGEVSVESE-----NYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ--- 589 +L+ + ++ E + + + + E + + QE+ E +++ E Q Sbjct: 377 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE 436 Query: 590 -LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPE 648 Q +E + + K + E M E++++ E + E ++E E ++ LPE Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE-QEEKEWQQQRLPE 495 Query: 649 IREKIEDAKESQ 660 +EK+ + ++ Q Sbjct: 496 QKEKLWEQEKMQ 507 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 70.5 bits (171), Expect = 6e-12 Identities = 142/656 (21%), Positives = 269/656 (41%), Gaps = 99/656 (15%) Query: 73 LGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTE--DESLVE 130 L ++ ET+ E G + K+ +L + +L +E +EEE GEK E L + Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616 Query: 131 NNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMD 187 + + + E+ ++ + + +EE K+ + + ++ + +D E+EK R + D Sbjct: 617 ARASAGDTRQVEVLKK--ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEAD 674 Query: 188 ISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSG 247 + EE ++ TL L + EEA ++A++ + E E + ++ Sbjct: 675 RGRELEEQNLQLQKTLQQLRQDCEEA---------SKAKMVA---EAEATVLGQRRAAVE 722 Query: 248 TDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPV 307 T ++E E ++ I+ +E++ KE L G AVE L ++ + Sbjct: 723 TTLRETQEENDEFRRR---ILGLEQQLKETR------GLVDGGEAVEAR---LRDKLQRL 770 Query: 308 DVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE----- 362 + + EE + S+ E G + A+ + E E A+ G E Sbjct: 771 EAEKQQLEEALNASQEEEG----------SLAAAKRALEARLEEAQRGLARLGQEQQTLN 820 Query: 363 -VSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTETKDGS---------GLE 411 E+ G++ VL + A + + D+T +E++ E + + Sbjct: 821 RALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYK 880 Query: 412 EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET----QER 467 EK R ++ +Q + K E+E G+ Q ++ + A +T +E Sbjct: 881 EKARREVADAQRQAKDWASEAEKTSGGLSR--LQDEIQRLRQALQASQAERDTARLDKEL 938 Query: 468 EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENK--SLQENEEEEIGNLELAWDMLDLA 525 Q +G E E + ++D+ ++ LE K L+ +EE +EL D ++ Sbjct: 939 LAQRLQGLEQEAENKKRSQDDRARQLKG---LEEKVSRLETELDEEKNTVELLTDRVNRG 995 Query: 526 KIIFKRQETKEAQLYAAQAHLKLGEVSVESEN-----YVQAVEEFQ----SCLNLQEQYL 576 + + T+ Q +A+ L+ ++S+E +N + + E FQ S L+ Q Sbjct: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ 1055 Query: 577 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIE-----------VIENRMAVLNEQV 625 +RL AE + L N + + V + S IE + R+ L QV Sbjct: 1056 LLQERLQAEEREKTVL-QSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114 Query: 626 KEAE-------GSSAEYKKEIEELKELLPEIREKIED-AKESQR--SGNVAELALK 671 EAE G + ++E+EE E+ +++ +I+ K+S R S + AE ALK Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALK 1170 Score = 34.3 bits (77), Expect = 0.46 Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 17/302 (5%) Query: 383 PSVVGDQTPIEPQTSIERLTET-----KDGSGLEE-----KVRAKLVPSQEETKLSVEES 432 P ++ DQ P S++ + T ++GS E KV L Q +S + Sbjct: 296 PDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355 Query: 433 EA-AGDGVDTKVAQGATEKSPEDKVQIAANEETQER-EEQMKEGEETEGSEEDDKENDKT 490 +A AG G T+ + K E+ + E +Q E Q++E E ++ E K Sbjct: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415 Query: 491 EEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 550 E ++ L+N ++ E++ + L +++L + Q + A+ + L+ E Sbjct: 416 EAQQSNKELQNMKRLLDQGEDLRH-GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474 Query: 551 VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGY-NSQYDEAVAQFSK 609 + E Q VEE L L+E+ L A L E + QY Q + Sbjct: 475 LLEEVLEGKQRVEEQ---LRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531 Query: 610 SIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELA 669 S++ AVL + ++ ++E+EE E + + KE R+ L Sbjct: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591 Query: 670 LK 671 L+ Sbjct: 592 LR 593 >gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4 [Homo sapiens] Length = 2073 Score = 68.2 bits (165), Expect = 3e-11 Identities = 106/493 (21%), Positives = 197/493 (39%), Gaps = 66/493 (13%) Query: 116 EEEEGEKT---EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK----- 167 EEEEG+ ++ NN N D +E + + + K+ K + L+K Sbjct: 1204 EEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNK 1263 Query: 168 -------------PETDKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLDWLTETSE 211 PET E D ++ +++ K++ P +E+V T + L E Sbjct: 1264 ERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEE 1323 Query: 212 EAKGGA-APEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSI 270 + AP PN + KPE ++ EEE+ + +EE E+G +E+ G + Sbjct: 1324 NRREETCAPVSPNTSP--GEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKD 1381 Query: 271 EEKPKEVSEEQPVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEKVVTSE--- 322 + K +E+P ++ EK+ +A E E E +P+ DE + + ++E Sbjct: 1382 PDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEK 1441 Query: 323 ----NEAGKAVLEQ---LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375 E+ K VLE + V P +PEV + SE E G + +P Sbjct: 1442 EELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAG-DPEAVP 1500 Query: 376 KDGAVNGPSVVGDQTPIEPQTSIERL-TETKDGSGLEEKVRAKLVPS-QEETKLSVEESE 433 + P G+Q + Q + + + TE K+G+ ++ ++ V + Q T+ S E+ + Sbjct: 1501 ESDEEPPP---GEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDD 1557 Query: 434 AAGDGVDTKVAQGATEK--SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTE 491 D +T+ A + + + QIA T + +Q ++ ++ Sbjct: 1558 TFQDCAETQEACRSLQNYTRADQSPQIAT---TLDDCQQSDHSSPVSSVHSHPGQSVRSV 1614 Query: 492 EMPNDSVLENKSLQENEEE------EIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAH 545 P+ LEN Q + ++ + N+E + M+D+ + + +Q Sbjct: 1615 NSPSVPALENSYAQISPDQSAISVPSLQNMETS-PMMDVPSV------SDHSQQVVDSGF 1667 Query: 546 LKLGEVSVESENY 558 LG + +ENY Sbjct: 1668 SDLGSIESTTENY 1680 Score = 55.5 bits (132), Expect = 2e-07 Identities = 104/488 (21%), Positives = 192/488 (39%), Gaps = 88/488 (18%) Query: 157 AKKTEDKSLAKPETDK--EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214 A +E++ A+ E ++ EQ S EK +E + ++ + KV +L Sbjct: 995 AAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPV 1054 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274 G E E++ E+E + E+E+ + +EE E+ +E++ E +I+ P Sbjct: 1055 TG---ERGQLLELSKESSEEE-EEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110 Query: 275 KEVSEEQ--------PVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEK---- 317 +++ Q P V +K+G V E++ T + ++ D +E+ Sbjct: 1111 PRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMP 1170 Query: 318 ------VVTSENEAGKAVLEQLV----GQEVPPAEE-----------SPEVTTEAAEASA 356 + E + K VL + G++ EE P ++S Sbjct: 1171 QLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSN 1230 Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPS----------------VVGDQTPIEP--QTSI 398 ++ GS+ + +P + V PK G G S +TP+EP Q ++ Sbjct: 1231 LKEGSKDNPEPLKCKQVWPK-GTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTV 1289 Query: 399 ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQI 458 E ET +G +R + + L +E + + + PED + I Sbjct: 1290 EEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDL-I 1348 Query: 459 AANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 518 EE +E EE+ +E EE EG EE+ N E+ P + QE EE EI Sbjct: 1349 KPEEEEEEEEEEEEEEEEEEGEEEEGGGN--VEKDP-----DGAKSQEKEEPEIST---- 1397 Query: 519 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAV---------EEFQSCL 569 + D A++ +E +E + +H + + E ++++++ E F+ L Sbjct: 1398 -EKEDSARLDDHEEEEEEDE---EPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVL 1453 Query: 570 NLQEQYLE 577 QE +L+ Sbjct: 1454 ENQETFLD 1461 Score = 54.3 bits (129), Expect = 4e-07 Identities = 98/428 (22%), Positives = 171/428 (39%), Gaps = 74/428 (17%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET----D 171 EEEE E+ E+E E + DEE EE E+ E+EE ++ L KP++ Sbjct: 1070 EEEEEEEDEEEEEEEEEEEEDEEEEEEEEEE------EEEENIQSSPPRLTKPQSVAIKR 1123 Query: 172 KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGK 231 K +K GR+ I+ S +T + ++ET+E NE S + Sbjct: 1124 KRPFVLKKKRGRKRRRINSS---------VTTETISETTEVL---------NEPFDNSDE 1165 Query: 232 PEQEVPDAEEEKSVSGTDVQEECRE----KGGQEKQGEVIVSIEEKPKE---VSEEQPVV 284 E+ +P E + +V+E+ R+ K Q + G+ + EE+ K+ P Sbjct: 1166 -ERPMPQLEPTCEI---EVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCR 1221 Query: 285 TLEKQGTAVEVEAESLDPTVKPVDVGGDEPE-EKVVTSENEAGKAVLEQLVGQEVPPAEE 343 ++ E +P +P+ P+ K S+ K E+ G ++ Sbjct: 1222 NNMNDDSSNLKEGSKDNP--EPLKCKQVWPKGTKRGLSKWRQNK---ERKTGFKL-NLYT 1275 Query: 344 SPEVTTEAAEASAVEAGSEVSEKPGQEAPV-LPKDGAVNGPSVVGDQTPIEPQTSIERLT 402 PE E E VE E SE +P+ + ++ G +++ + +T Sbjct: 1276 PPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSP 1335 Query: 403 ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---------- 452 T G E+ + + P +EE + EE E + + + G EK P Sbjct: 1336 NTSPGEKPEDDL---IKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEE 1392 Query: 453 -------EDKVQIAANEETQEREEQMKEGEETEGSEEDDKEND----KTEEMPNDSVLEN 501 ED ++ +EE +E +E+ E+ + +EDD + + EE+P +S Sbjct: 1393 PEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESF--- 1449 Query: 502 KSLQENEE 509 K + EN+E Sbjct: 1450 KEVLENQE 1457 Score = 33.1 bits (74), Expect = 1.0 Identities = 15/60 (25%), Positives = 31/60 (51%) Query: 715 LVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774 L++ + + EEE +++ ++ + E E GG+ + P G + E E E + E A ++ Sbjct: 1347 LIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLD 1406 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 66.6 bits (161), Expect = 8e-11 Identities = 116/561 (20%), Positives = 233/561 (41%), Gaps = 69/561 (12%) Query: 142 ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS----------EMEKGGREDMDISKS 191 ++ Q + M ++EE K +K LA E ++ ++++ + + ++ Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898 Query: 192 AEEPQEKVDLTLDWLTETSE--EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249 AEE + ++ L E EA+ E + K +Q + + EE+ + Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ-----LE 953 Query: 250 VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 309 +E R+K EK V+ E K K++ EEQ + LE Q + E + L+ + Sbjct: 954 EEESARQKLQLEK-----VTTEAKLKKLEEEQ--IILEDQNCKLAKEKKLLEDRIAEFTT 1006 Query: 310 GGDEPEEKV-----VTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVS 364 E EEK + +++EA LE+ + +E +E E T E + + +++ Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL-EKTRRKLEGDSTDLSDQIA 1065 Query: 365 EKPGQEAPV----LPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG-SGLEEKV---RA 416 E Q A + K+ + ++ + +++++ E + S L+E + RA Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125 Query: 417 KLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQI---AANEETQEREE 469 ++++ + EE EA D +D+ AQ E +V I EE + E Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185 Query: 470 QMKEGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 527 Q++E + ++ EE ++ ++T+ + ++ + K ENE E+ N E+ + Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELAN-EVKVLLQGKGDS 1243 Query: 528 IFKRQETKEAQLYAAQAHLKLGE------------VSVESENYVQAVEEFQSCLNLQEQY 575 KR++ EAQL Q GE + VE +N + + S + + Sbjct: 1244 EHKRKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302 Query: 576 LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEY 635 A + L +T L + + S ++ +E+ EQ++E E + Sbjct: 1303 FSALESQLQDTQELL-------QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355 Query: 636 KKEIEELKELLPEIREKIEDA 656 +K+I L + ++++K+ED+ Sbjct: 1356 EKQIATLHAQVADMKKKMEDS 1376 Score = 60.1 bits (144), Expect = 8e-09 Identities = 124/620 (20%), Positives = 241/620 (38%), Gaps = 128/620 (20%) Query: 137 EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQ 196 E+ + REQ + E+EEAK +K +A T Q ++M+K + + ++AEE + Sbjct: 1335 EDEKNSFREQ----LEEEEEAKHNLEKQIA---TLHAQVADMKKKMEDSVGCLETAEEVK 1387 Query: 197 EKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDA----------------- 239 K+ L+ L++ EE ++ E T + +QE+ D Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAY-----DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442 Query: 240 --------EEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291 EEK++S +E R + ++ +S+ +E E++ LE+ Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK--AELERLNK 1500 Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351 E E L + DVG E E K LEQ V +E+ E E +A Sbjct: 1501 QFRTEMEDLMSSKD--DVGKS-------VHELEKSKRALEQQV-EEMKTQLEELEDELQA 1550 Query: 352 AEASAVEAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 410 E + + + Q E + +D +Q+ + + + ++ E + Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDLQGRD----------EQSEEKKKQLVRQVREMEAELED 1600 Query: 411 EEKVRAKLVPSQEETKLSVEESEAAGDGVDT----------------KVAQGATEKSPED 454 E K R+ V ++++ ++ +++ EA D + K + + Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660 Query: 455 KVQIAANEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----V 498 + +I A + E++ + E E + EE + ++ +E+ N S Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720 Query: 499 LENK--------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 550 LE K L+E EEE GN EL D L A + + T L ++H + Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT---DLNLERSHAQ--- 1774 Query: 551 VSVESENYVQAVEEFQSCLNLQEQYLE------------AHDRLLAETHYQLGLAYGYNS 598 ++EN Q +E L ++ Q +E A + +A+ QL N Sbjct: 1775 ---KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD-----NE 1826 Query: 599 QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 658 + A K + E ++ + QV + ++ +YK + ++ L +++ ++E+A+E Sbjct: 1827 TKERQAA--CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884 Query: 659 SQRSGNVAELALKATLVESS 678 + N + L+ L +++ Sbjct: 1885 EAQRANASRRKLQRELEDAT 1904 Score = 40.4 bits (93), Expect = 0.006 Identities = 57/283 (20%), Positives = 112/283 (39%), Gaps = 28/283 (9%) Query: 519 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQS-----CLNLQE 573 W + K + + +E + + +K+ E + +EN + +E QS L LQE Sbjct: 828 WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887 Query: 574 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633 Q L+A L AE + +E +E E R L + K+ + + Sbjct: 888 Q-LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946 Query: 634 EYKKEIEE---------LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP 684 E ++++EE L+++ E + K + ++ +LA + L+E + FT Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006 Query: 685 GGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGG 744 + K + +TD+ +R++ K +E +K +++ E Sbjct: 1007 NLTEEEEKSKSLAKLKN--KHEAMITDLEERLRREEKQRQE------LEKTRRKLE---- 1054 Query: 745 SGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTA 787 GD+ ++++E + AE + + E A A VE A Sbjct: 1055 -GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 66.6 bits (161), Expect = 8e-11 Identities = 87/387 (22%), Positives = 166/387 (42%), Gaps = 34/387 (8%) Query: 114 HVEEEEG-----EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168 H E+E+G EK + E + + I+++ + E + + K A+K+E+K+ K Sbjct: 164 HKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKT-AEKSEEKT--KK 220 Query: 169 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN---EA 225 E + ++++ + ++ K+ +P+EK D +++ ++ + + Sbjct: 221 EVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHG 280 Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285 ++ G+ P E++ T EK G++K+ E V+ E K KE ++ + Sbjct: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE---KEDIKK 337 Query: 286 LEKQGTAVEVE-------AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEV 338 ++ TA++VE +E+ TVK + +EK S+ A +EQ G++ Sbjct: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ 397 Query: 339 PPAEESPEVTTEAAEASAVEAGSEV---SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 395 E+ E + +V + +V +E+ +E + AV G +E + Sbjct: 398 EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE 457 Query: 396 TSIERLTET----KDGS---GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK--VAQG 446 E+ +T KD G EEKV A L + ETK E+ AG V K QG Sbjct: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD-EKMSKAGKEVKPKPPQLQG 516 Query: 447 ATEKSPEDKVQIAANEETQEREEQMKE 473 E+ PE +++ A E+ + K+ Sbjct: 517 KKEEKPEPQIKKEAKPAISEKVQIHKQ 543 Score = 45.8 bits (107), Expect = 2e-04 Identities = 61/272 (22%), Positives = 118/272 (43%), Gaps = 34/272 (12%) Query: 122 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE------TDKEQD 175 K ++ + ++ ++ + + +V G+K+E K+ + P+ +DK+ Sbjct: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423 Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 235 ++ E+ E +S P +K + T + + + K G + E GK E++ Sbjct: 424 AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK-EEK 482 Query: 236 VPDAEEEKSVSGTDVQEECREKGGQE---KQGEVIVSIEEKPK-EVSEEQPVVTLEKQGT 291 VP + +EK ++E K G+E K ++ EEKP+ ++ +E EK Sbjct: 483 VPASLKEKEPE--TKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK--- 537 Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKV------VTSENEAGKAVLEQLVGQEVPP----- 340 V++ + + K V G +PEEKV VT E A ++ +E P Sbjct: 538 -VQIHKQDIVKPEKTVSHG--KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKT 594 Query: 341 --AEESPEVTTEAAEASAVEAGSEVSEKPGQE 370 + +P+ T+E E+ + +E+SEK +E Sbjct: 595 DKPKPTPKGTSEVTESG--KKKTEISEKESKE 624 Score = 37.7 bits (86), Expect = 0.042 Identities = 73/363 (20%), Positives = 136/363 (37%), Gaps = 39/363 (10%) Query: 431 ESEAAGDGVDTKVAQGATEKSPEDKVQIAANE-ETQEREEQMKEGEETEGSEEDDKENDK 489 E E DG D +G ++ P K +I ++ E QE+ E+ + + T +E KE + Sbjct: 117 EDEEDDDG-DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175 Query: 490 TEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA------Q 543 +E P + +++ E+ E L AK K +E + ++ Q Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKK---AKTAEKSEEKTKKEVKGGKQEKVKQ 232 Query: 544 AHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLE-AHDRLLAETHYQLGLAYGYNSQYDE 602 K+ EV + ++ ++ ++ EQ + A R + + L G + Sbjct: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292 Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI-EELKELLPEIREKIEDAKESQR 661 + S R + ++E EG + +K++ E K+ +EK + K+S++ Sbjct: 293 PLPTEQAS------RPTPASPALEEKEGEKKKAEKKVTSETKK-----KEKEDIKKKSEK 341 Query: 662 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721 E A+ E + T G + A++K S +K + Sbjct: 342 -----ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK--------TKKPAE 388 Query: 722 PEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAE--NQAESRAAVEGTVEA 779 E+ +K + K+ EP + +VPS +V E E + AV G E Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448 Query: 780 GAT 782 T Sbjct: 449 KTT 451 >gi|24415404 MDN1, midasin homolog [Homo sapiens] Length = 5596 Score = 66.2 bits (160), Expect = 1e-10 Identities = 119/602 (19%), Positives = 230/602 (38%), Gaps = 109/602 (18%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175 +EEE E+ ED E +DEE E + + G + K +DK +++++ Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKK------EEKEE 4836 Query: 176 SEMEKGGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232 +E + GG+ + I++ +E + +VD P N+ +V P Sbjct: 4837 AEADDGGQGEDKINEQIDERDYDENEVD------------------PYHGNQEKV----P 4874 Query: 233 EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 292 E E D ++ ++ D + + +E + E + I+EKP+E E E++G Sbjct: 4875 EPEALDLPDDLNLDSED-KNGGEDTDNEEGEEENPLEIKEKPEEAGHE-----AEERGET 4928 Query: 293 VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 352 + ES P EPEE + G+ ++ + A + PE +E Sbjct: 4929 ETDQNESQSP---------QEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQ 4979 Query: 353 EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEE 412 + S E E E+ G+ NGP+ G Q P E + + TE + LE Sbjct: 4980 QQSVEEKDKEADEEGGE-----------NGPADQGFQ-PQEEEEREDSDTEEQVPEALER 5027 Query: 413 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQ-----GATEKSPEDK------VQIAAN 461 K A + E + + E AG + + + GA + + + Q+A+ Sbjct: 5028 KEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQ 5087 Query: 462 EETQEREEQMKE-----GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516 + T++ + K E + +++ + + + DS E Q+ + + Sbjct: 5088 KHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQV----- 5142 Query: 517 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCL---NLQE 573 + D + I + + +AQ Y + K + S + Q EE + L QE Sbjct: 5143 ---EDADAFEHIKQGSDAYDAQTYDVAS--KEQQQSAKDSGKDQEEEEIEDTLMDTEEQE 5197 Query: 574 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633 ++ A L + G +DE + ++++ E++ ++ KE E Sbjct: 5198 EFKAADVEQLKPEEIKSGTTAPLG--FDEMEVEI-QTVKTEEDQDPRTDKAHKETENEKP 5254 Query: 634 EYKKE------------------IEELKELLPEIREKIEDAKESQRSGNVAELALKATLV 675 E +E ++++ EL E+ ++E + + SGN E + A + Sbjct: 5255 ERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQLE-MWQPRESGNPEEEKVAAEMW 5313 Query: 676 ES 677 +S Sbjct: 5314 QS 5315 Score = 60.5 bits (145), Expect = 6e-09 Identities = 84/387 (21%), Positives = 156/387 (40%), Gaps = 55/387 (14%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNID--EEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168 E + + ++ +ED++ E+ DN + EE E++E+ +A E EE +TE Sbjct: 4877 EALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETD----- 4931 Query: 169 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 228 + + + E E+G ED E +E++D T + + G A + P E Sbjct: 4932 QNESQSPQEPEEGPSED-----DKAEGEEEMD--------TGADDQDGDAAQHPEE---H 4975 Query: 229 SGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288 S + +Q V + ++E G + G QG EE+ +EEQ LE+ Sbjct: 4976 SEEQQQSVEEKDKEADEEGGE--------NGPADQGFQPQEEEEREDSDTEEQVPEALER 5027 Query: 289 Q--GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 346 + + + E++ T + +++ G PE++ E+ +G A Q G ES Sbjct: 5028 KEHASCGQTGVENMQNT-QAMELAGAAPEKEQGKEEHGSGAADANQAEG------HESNF 5080 Query: 347 VTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD 406 + A++ + KPGQ + +GD + + T D Sbjct: 5081 IAQLASQKHTRKNTQSFKRKPGQ----------ADNERSMGDH-----NERVHKRLRTVD 5125 Query: 407 GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQE 466 E+ A+ +Q E + E + D D + A+++ + ++E +E Sbjct: 5126 TDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEE 5185 Query: 467 REEQMKEGEETEGSEEDDKENDKTEEM 493 E+ + + EE E + D E K EE+ Sbjct: 5186 IEDTLMDTEEQEEFKAADVEQLKPEEI 5212 Score = 34.3 bits (77), Expect = 0.46 Identities = 75/386 (19%), Positives = 145/386 (37%), Gaps = 52/386 (13%) Query: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ 465 +G G+ E K V Q + VE++ G D + ++ ED A E ++ Sbjct: 4676 EGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDN----AIEMSE 4731 Query: 466 EREEQMKEGEETEGSEEDDKE--------------NDKTEEMPNDSVLENKSLQENEEEE 511 + + +M +GE E E+D+K N + + ++ + + +E+EEEE Sbjct: 4732 DFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEE 4791 Query: 512 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 571 E +D ++++L A +L G + + + E+ ++ + Sbjct: 4792 DNKTEETGPGMD----------EEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADD 4841 Query: 572 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 631 Q + + + E Y Y+ ++ +++++ ++ LN ++ G Sbjct: 4842 GGQGEDKINEQIDERDYDENEVDPYHGNQEKVPE--PEALDLPDD----LNLDSEDKNGG 4895 Query: 632 SAEYKKEIEELKELLPEIREKIEDA-KESQRSGNVAELALKATLVESSTSGFTPGGGGSS 690 +E EE L EI+EK E+A E++ G T S S P G S Sbjct: 4896 EDTDNEEGEEENPL--EIKEKPEEAGHEAEERGET------ETDQNESQSPQEPEEGPSE 4947 Query: 691 VSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDA--KKAKQEPEVNGGSGDA 748 + D + H PEE S + + +K K+ E G +G A Sbjct: 4948 DDKAEGEEEMDTGADDQDGDAAQH-------PEEHSEEQQQSVEEKDKEADEEGGENGPA 5000 Query: 749 VPSGNEVSENMEEEAENQAESRAAVE 774 E E+++ + + A+E Sbjct: 5001 DQGFQPQEEEEREDSDTEEQVPEALE 5026 >gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] Length = 2454 Score = 65.1 bits (157), Expect = 2e-10 Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%) Query: 154 KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213 KE+ + DK L + E +E+ + K +++ S+ + +E + TS + Sbjct: 1080 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1138 Query: 214 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 273 K E + TS K +Q + S S +D++++ + G+ S E+K Sbjct: 1139 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1187 Query: 274 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 333 K V+E +V G E+L +V PV V D+ + EN K +L + Sbjct: 1188 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1241 Query: 334 VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 393 + + E+ + + E G + E PG E + + S + Sbjct: 1242 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1299 Query: 394 PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 447 + +LT + SG E+K + K V + K+S E+SE + GV +V++ Sbjct: 1300 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1359 Query: 448 TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503 E+ P K ++ N+ + +++++ + + E S ++K N + EE + E + Sbjct: 1360 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419 Query: 504 LQENEEEE 511 +E EEE+ Sbjct: 1420 EEEEEEED 1427 Score = 42.4 bits (98), Expect = 0.002 Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%) Query: 145 EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 204 ++V D + + E +D+S E DK+Q + + ++ D K + +++ + + D Sbjct: 917 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 976 Query: 205 WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 248 + E + P+G + + T G K + E+ D E+ + G Sbjct: 977 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1036 Query: 249 DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304 D E+ + K G ++K+ +++ K ++ S ++ + E S D + Sbjct: 1037 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1091 Query: 305 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 363 K +++ E + ++S+ + E G AEES E + + S+ + V Sbjct: 1092 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1143 Query: 364 SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 420 EK K + S + Q SI +GS E+K++ LV Sbjct: 1144 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1197 Query: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 473 S EA V V + PE+++ +I AN + E+ + Sbjct: 1198 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1255 Query: 474 GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 532 E EG + K+N EE P D +N+ E++ + + + + L K+ Sbjct: 1256 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1312 Query: 533 ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 589 E+ E + + H ++ V SE+ + +FQ + E+ E+ D T Sbjct: 1313 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1366 Query: 590 LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 645 + +K E+ EN+ + + ++K E SS+E K EE +E Sbjct: 1367 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1410 Query: 646 LPEIREKIEDAKESQRSGN 664 E E+ E+ +E + N Sbjct: 1411 KEEEEEEEEEEEEEEEDEN 1429 Score = 38.9 bits (89), Expect = 0.019 Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%) Query: 175 DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232 D + K +D +P+ ++ + L+ + + G++ + P E + +GK Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268 Query: 233 EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288 +E P EE K S S +D +E + + + + + E + +P E Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1328 Query: 289 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348 +G + V+SE+ E V +EV +E+ Sbjct: 1329 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365 Query: 349 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 408 T +A+ + +E ++ + + ++ + +E K S Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1404 Query: 409 GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 463 EE+ + +EE + EE E D D + G K +DK++ Sbjct: 1405 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1458 Query: 464 TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 510 +E EE+ K E E E +E + E+ P + K + + +EE Sbjct: 1459 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1506 Score = 34.3 bits (77), Expect = 0.46 Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%) Query: 108 NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 167 N+ E +EEE E+ E+E E ++N D ++ + R+++ + K++ +TE ++ K Sbjct: 1403 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1460 Query: 168 PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214 E + +++ +E E+ + ++ + + K +T + + EE K Sbjct: 1461 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1508 Score = 31.6 bits (70), Expect = 3.0 Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%) Query: 153 EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 206 +K ++ K+ S K +T E DSE+EK E +SK +A ++++ T D+ Sbjct: 755 KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 811 Query: 207 TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 266 +E + +K G +G + + + +E ++ S + G +K + Sbjct: 812 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 863 Query: 267 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326 + + PK+ ++K + E SL+ V+ V E +EK + + Sbjct: 864 MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 916 Query: 327 KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 379 K V + L + ++ ++S E + + + S + G+E +KP + K + + Sbjct: 917 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 974 Query: 380 VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 437 +G + ++ I P+ + T DG +K+R K ++E E+S GD Sbjct: 975 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1034 Query: 438 GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 493 D+ K GA + +K + ++ + + + + S ++D N + + Sbjct: 1035 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1091 Query: 494 PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 542 + E ++L + +EI + + D + ++ K+++ KE + + Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1151 Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 598 + K + + S + ++ Q+ + + EQ ++ + L+ +H + G Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1208 Query: 599 QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 637 DEA+ SKS+ V ENR+A +L E++K + +GSS E KK Sbjct: 1209 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1263 Query: 638 EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 686 + E P E + ++ D++ES++ L V SG T Sbjct: 1264 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1323 Query: 687 GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 739 V RK + S + + +E+ PR AKKA+ E Sbjct: 1324 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1383 Query: 740 -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774 +V S S +E E +EE E + E E Sbjct: 1384 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425 Score = 31.6 bits (70), Expect = 3.0 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Query: 122 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 180 K +++S EN N +EE E+ E+ + E+EE + +D KS K + + +K Sbjct: 1391 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450 Query: 181 GGREDMDISKSAEEPQEKV 199 E + K EE ++++ Sbjct: 1451 LRTETQNALKEEEERRKRI 1469 >gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] Length = 2492 Score = 65.1 bits (157), Expect = 2e-10 Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%) Query: 154 KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213 KE+ + DK L + E +E+ + K +++ S+ + +E + TS + Sbjct: 1118 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1176 Query: 214 KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 273 K E + TS K +Q + S S +D++++ + G+ S E+K Sbjct: 1177 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1225 Query: 274 PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 333 K V+E +V G E+L +V PV V D+ + EN K +L + Sbjct: 1226 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1279 Query: 334 VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 393 + + E+ + + E G + E PG E + + S + Sbjct: 1280 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1337 Query: 394 PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 447 + +LT + SG E+K + K V + K+S E+SE + GV +V++ Sbjct: 1338 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1397 Query: 448 TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503 E+ P K ++ N+ + +++++ + + E S ++K N + EE + E + Sbjct: 1398 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457 Query: 504 LQENEEEE 511 +E EEE+ Sbjct: 1458 EEEEEEED 1465 Score = 42.4 bits (98), Expect = 0.002 Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%) Query: 145 EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 204 ++V D + + E +D+S E DK+Q + + ++ D K + +++ + + D Sbjct: 955 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 1014 Query: 205 WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 248 + E + P+G + + T G K + E+ D E+ + G Sbjct: 1015 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1074 Query: 249 DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304 D E+ + K G ++K+ +++ K ++ S ++ + E S D + Sbjct: 1075 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1129 Query: 305 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 363 K +++ E + ++S+ + E G AEES E + + S+ + V Sbjct: 1130 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1181 Query: 364 SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 420 EK K + S + Q SI +GS E+K++ LV Sbjct: 1182 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1235 Query: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 473 S EA V V + PE+++ +I AN + E+ + Sbjct: 1236 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1293 Query: 474 GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 532 E EG + K+N EE P D +N+ E++ + + + + L K+ Sbjct: 1294 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1350 Query: 533 ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 589 E+ E + + H ++ V SE+ + +FQ + E+ E+ D T Sbjct: 1351 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1404 Query: 590 LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 645 + +K E+ EN+ + + ++K E SS+E K EE +E Sbjct: 1405 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1448 Query: 646 LPEIREKIEDAKESQRSGN 664 E E+ E+ +E + N Sbjct: 1449 KEEEEEEEEEEEEEEEDEN 1467 Score = 38.9 bits (89), Expect = 0.019 Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%) Query: 175 DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232 D + K +D +P+ ++ + L+ + + G++ + P E + +GK Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1306 Query: 233 EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288 +E P EE K S S +D +E + + + + + E + +P E Sbjct: 1307 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1366 Query: 289 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348 +G + V+SE+ E V +EV +E+ Sbjct: 1367 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403 Query: 349 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 408 T +A+ + +E ++ + + ++ + +E K S Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1442 Query: 409 GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 463 EE+ + +EE + EE E D D + G K +DK++ Sbjct: 1443 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1496 Query: 464 TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 510 +E EE+ K E E E +E + E+ P + K + + +EE Sbjct: 1497 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1544 Score = 34.3 bits (77), Expect = 0.46 Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%) Query: 108 NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 167 N+ E +EEE E+ E+E E ++N D ++ + R+++ + K++ +TE ++ K Sbjct: 1441 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1498 Query: 168 PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214 E + +++ +E E+ + ++ + + K +T + + EE K Sbjct: 1499 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1546 Score = 31.6 bits (70), Expect = 3.0 Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%) Query: 153 EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 206 +K ++ K+ S K +T E DSE+EK E +SK +A ++++ T D+ Sbjct: 793 KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 849 Query: 207 TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 266 +E + +K G +G + + + +E ++ S + G +K + Sbjct: 850 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 901 Query: 267 IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326 + + PK+ ++K + E SL+ V+ V E +EK + + Sbjct: 902 MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 954 Query: 327 KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 379 K V + L + ++ ++S E + + + S + G+E +KP + K + + Sbjct: 955 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 1012 Query: 380 VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 437 +G + ++ I P+ + T DG +K+R K ++E E+S GD Sbjct: 1013 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1072 Query: 438 GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 493 D+ K GA + +K + ++ + + + + S ++D N + + Sbjct: 1073 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1129 Query: 494 PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 542 + E ++L + +EI + + D + ++ K+++ KE + + Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1189 Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 598 + K + + S + ++ Q+ + + EQ ++ + L+ +H + G Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1246 Query: 599 QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 637 DEA+ SKS+ V ENR+A +L E++K + +GSS E KK Sbjct: 1247 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1301 Query: 638 EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 686 + E P E + ++ D++ES++ L V SG T Sbjct: 1302 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1361 Query: 687 GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 739 V RK + S + + +E+ PR AKKA+ E Sbjct: 1362 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1421 Query: 740 -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774 +V S S +E E +EE E + E E Sbjct: 1422 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463 Score = 31.6 bits (70), Expect = 3.0 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Query: 122 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 180 K +++S EN N +EE E+ E+ + E+EE + +D KS K + + +K Sbjct: 1429 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488 Query: 181 GGREDMDISKSAEEPQEKV 199 E + K EE ++++ Sbjct: 1489 LRTETQNALKEEEERRKRI 1507 >gi|210032580 SET domain containing 1B [Homo sapiens] Length = 1923 Score = 64.7 bits (156), Expect = 3e-10 Identities = 68/296 (22%), Positives = 116/296 (39%), Gaps = 10/296 (3%) Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---KPETDK 172 E + + D+ + + ++DEE E RE+ D E K + K + +P Sbjct: 968 EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL 1027 Query: 173 EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232 E DS E+ +E + + + E +E+ + + + +++ E +E S Sbjct: 1028 ELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEAS 1087 Query: 233 EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 292 E++ D++EE++VS + E + E S E P +E+ VV E++ Sbjct: 1088 EKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEE 1147 Query: 293 VEVE--AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG--QEVPPAEESPEVT 348 E E AE + P D D E + +E+ V E EE P + Sbjct: 1148 EEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSML 1207 Query: 349 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTE 403 E VE ++ E P E P L ++GA + P + P S ER E Sbjct: 1208 DEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPE 1261 Score = 54.3 bits (129), Expect = 4e-07 Identities = 79/294 (26%), Positives = 120/294 (40%), Gaps = 42/294 (14%) Query: 120 GEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD---- 175 GE+ E ESL E ++ +EE EE E E+EE +D S + E++ + + Sbjct: 1033 GEEDEKESLSEEQESTEEE--EEAEE-------EEEEEDDDDDDSDDRDESENDDEDTAL 1083 Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 235 SE + D D ++ K + T +S E+ + E +E+ +S + E+E Sbjct: 1084 SEASEKDEGDSDEEETVSIVTSKAEAT------SSSESSESSEFESSSESSPSSSEDEEE 1137 Query: 236 VPDAEEEKSVSGTD-VQEECREKGGQ---EKQGEVIVSIEEKPKEVS---EEQPVVTLEK 288 V EEE+ + V EE G E+ GE P S EE+ V +E Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEE--VDIET 1195 Query: 289 QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348 + A E LD P+ VG +EP + E E G + ++ PPA+E E Sbjct: 1196 EAVAPEERPSMLDE--PPLPVGVEEPADSREPPE-EPGLSQEGAMLLSPEPPAKE-VEAR 1251 Query: 349 TEAAEASAVEAGSEVSEKPGQEAPV-----LPKDGAVNGPSVVGDQTPIEPQTS 397 + A E EV +P P+ LP PS P EP+T+ Sbjct: 1252 PPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPS-----PPPEPETT 1300 Score = 53.5 bits (127), Expect = 7e-07 Identities = 75/333 (22%), Positives = 121/333 (36%), Gaps = 45/333 (13%) Query: 102 ENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE 161 E L E EEE E+ E+E +++ + +E+ + + EK+E E Sbjct: 1037 EKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDE 1096 Query: 162 DKSL----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEE--AKG 215 ++++ +K E +S + S S+ E +E+V + E EE A+ Sbjct: 1097 EETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEE 1156 Query: 216 GAAPEGP-------NEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR------------- 255 A GP EA + G P + EEE + V E R Sbjct: 1157 SMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGV 1216 Query: 256 ----------EKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVK 305 E+ G ++G +++S E KEV P+ +EVE E P + Sbjct: 1217 EEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPE--PPMML 1274 Query: 306 PVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP---AEESPEVTTEAAEASAVEAGSE 362 P+ + P + + + VPP AE+ P T + A +E Sbjct: 1275 PLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTE 1334 Query: 363 -VSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEP 394 V PG E P+ G +G S+ Q P P Sbjct: 1335 TVPATPGGEPPL---SGGSSGLSLSSPQVPGSP 1364 Score = 50.1 bits (118), Expect = 8e-06 Identities = 47/202 (23%), Positives = 93/202 (46%), Gaps = 25/202 (12%) Query: 387 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQG 446 GDQ + P TS++ E + E+ R +T + + + G GV + A+ Sbjct: 976 GDQKRLRPSTSVDEEDEESE----RERDR-----DMADTPCELAKRDPKGVGVRRRPARP 1026 Query: 447 ATEKS---PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503 S ++K ++ +E+ E EE+ +E EE E ++DD ++D +E ND E+ + Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEE--DDDDDDSDDRDESENDD--EDTA 1082 Query: 504 LQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVE 563 L E E++ G+ D + I+ T +A+ ++ + E SE+ + E Sbjct: 1083 LSEASEKDEGDS----DEEETVSIV-----TSKAEATSSSESSESSEFESSSESSPSSSE 1133 Query: 564 EFQSCLNLQEQYLEAHDRLLAE 585 + + + +E+ E + ++AE Sbjct: 1134 DEEEVVAREEEEEEEEEEMVAE 1155 Score = 45.1 bits (105), Expect = 3e-04 Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 54/263 (20%) Query: 259 GQEKQGEVIVSIEEKPKEVSEEQ-------PVVTLEKQGTAVEVEAESLDPTVKPVDVGG 311 G +K+ S++E+ +E E+ P ++ V V P +D GG Sbjct: 976 GDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL--ELDSGG 1033 Query: 312 DEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEA 371 +E E++ ++ E E+ TE E EA E E+ + Sbjct: 1034 EEDEKESLSEEQES-----------------------TEEEE----EAEEEEEEEDDDDD 1066 Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE 431 +D + N + T++ +E +G EE+ +V S+ E S E Sbjct: 1067 DSDDRDESEND----------DEDTALSEASEKDEGDSDEEET-VSIVTSKAEATSSSES 1115 Query: 432 SEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE---TEGSEEDDKEND 488 SE++ + + + ++ S ED+ ++ A EE +E EE+ EE + G E+ +++ + Sbjct: 1116 SESS----EFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGE 1171 Query: 489 KTEEMPNDSVLENKSLQENEEEE 511 + P +++ ++E + E Sbjct: 1172 EAALAPGAPAVDSLGMEEEVDIE 1194 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 64.3 bits (155), Expect = 4e-10 Identities = 112/543 (20%), Positives = 225/543 (41%), Gaps = 76/543 (13%) Query: 135 IDEEAREELREQVYD-AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAE 193 ++ + EELR++ M E K+ +D K + D++ + E+ G D+S Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG----DLSFKLR 328 Query: 194 EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEE 253 E + D L E +EE ++ T E++ A+ EK +S ++ Sbjct: 329 EFASHLQQLQDALNELTEE-----------HSKATQEWLEKQ---AQLEKELSAALQDKK 374 Query: 254 CREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDE 313 C E+ + QG+ + +EE ++ + P E G +++E +L + + Sbjct: 375 CLEEKNEILQGK-LSQLEEHLSQLQDNPPQEKGEVLGDVLQLE--TLKQEAATLAANNTQ 431 Query: 314 PEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA-SAVEAGSEVSEKPGQEAP 372 + +V E E G+ + L+ + EE ++++ + S++ S+ E+ Q + Sbjct: 432 LQARVEMLETERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ 490 Query: 373 VLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES 432 S+ + T + +I++ + ++ +GL+++ + K Q + ++++ Sbjct: 491 AHGARLTAQVASLTSELTTLN--ATIQQ--QDQELAGLKQQAKEK----QAQLAQTLQQQ 542 Query: 433 EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKE-GEETEGSEEDDKENDKTE 491 E A G+ +V Q + +++E+Q+KE E+ E + +D + T Sbjct: 543 EQASQGLRHQVEQ--------------LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588 Query: 492 EMPNDSVLEN-----KSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHL 546 ++ L K L+ E+E+ LE+ L +A + AQ QA Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-----EARDSAQTSVTQAQR 643 Query: 547 KLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQ 606 + E+S + VEE Q+C+ Q +AE QL + + E VAQ Sbjct: 644 EKAELS-------RKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQ 695 Query: 607 FSKSIEVIENRMAVLNEQVKEAEGSSAEYKKE----IEE----LKELLPEIREKIEDAKE 658 + ++ ++ L E +K +GS E K+ +EE + EL E R +E K Sbjct: 696 ---EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752 Query: 659 SQR 661 ++ Sbjct: 753 ERK 755 Score = 60.1 bits (144), Expect = 8e-09 Identities = 126/636 (19%), Positives = 243/636 (38%), Gaps = 109/636 (17%) Query: 113 VHVEEEEGEKTEDESLVENNDNIDEEAR-------------EELREQVYDAMGEKEEA-- 157 + + E+ + TE E + + D + E+ + EE + + DA+ E++ Sbjct: 678 LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737 Query: 158 -KKTEDKSLAKPETDKEQDSEMEKGGREDMD--ISKSAEEPQEKVDLTLDWLTET----- 209 K E +SL + + ++ E E+ GR+ ++ + + E Q + ++ L E Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797 Query: 210 ------------------------SEEAKGGAA-PEGPNEAEVTSGKPEQEVPDAEEEKS 244 EEA+ GA E + K QE+ +A+E+ Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-- 855 Query: 245 VSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304 V+G + E + Q + E+ ++ ++V E++ V +K + E + T Sbjct: 856 VAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLSTLQEKMAATS 913 Query: 305 KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE------AAEASAVE 358 K V E +V E + +LV + + PE E + +A++ Sbjct: 914 KEV-----ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968 Query: 359 AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS----GLEEKV 414 A +E+ G E L A+ + + + + RLT+ + + LE+ Sbjct: 969 AMEREAEQMGNELERLR--AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026 Query: 415 RAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK----------VQIAANEET 464 RA+L + + ++ E + +A TEK +D+ QI EE Sbjct: 1027 RAEL---EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083 Query: 465 QEREEQMKEG------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 518 ++ +Q+KE E GS + +TE P LE + ++ E+ + Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE--PTGPKLEALRAEVSKLEQ--QCQKQ 1139 Query: 519 WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEA 578 + D + + + A+ +A L + + E Q + QS L ++ L A Sbjct: 1140 QEQADSLERSLEAERASRAERDSA-----LETLQGQLEEKAQELGHSQSALASAQRELAA 1194 Query: 579 -----HDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633 D AE ++ +A G + + + I +E +++LN QV E EG S Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGR-----QEAERKNSLISSLEEEVSILNRQVLEKEGESK 1249 Query: 634 EYKKEIEELKELLPEIREKIE--DAKESQRSGNVAE 667 E K+ + E ++ E++ A+ + S AE Sbjct: 1250 ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285 Score = 37.7 bits (86), Expect = 0.042 Identities = 119/692 (17%), Positives = 264/692 (38%), Gaps = 92/692 (13%) Query: 115 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET-DKE 173 VE+ + E ++ E R++ +Q+ A E+E + + D +L + E +KE Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612 Query: 174 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSG 230 + +++E ++ +++ + Q V E S EE + + E + Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672 Query: 231 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI---VSIEEKPKEVSEEQPVVTLE 287 E E+ E++ T+ + +EK ++Q + + + + + E + + LE Sbjct: 673 VAELELQLRSEQQ--KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730 Query: 288 KQGTAV-EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 346 +Q + E++AE+ + E+ E AG+ LE + Q + E Sbjct: 731 EQQRCISELKAETR-------SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783 Query: 347 V-TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI--ERLTE 403 V E AEA A + +E E L K+ A Q ++ E+L Sbjct: 784 VLRRELAEAMAAQHTAE------SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837 Query: 404 TKDGSGLEEKVRAKL---------VPSQEETKLSVEESEAAGDGVD-TKVAQGATEKSPE 453 K+ EK R +L + S E ++S +++E A + + Q EK E Sbjct: 838 LKEEC---EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK--E 892 Query: 454 DKVQIAANEETQEREEQMKEGEET---------EGSEEDDKENDKTEEMPNDSVLENKSL 504 + Q A++ + +E+ +E G +++ + +E + + L Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952 Query: 505 QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 564 +E + + + + A + E + Q+ L+ + + + + ++ Sbjct: 953 EEQQGRQFCSTQAA----------LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002 Query: 565 FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV---L 621 + L ++ A L E + L + +E +F+ E + + + Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062 Query: 622 NEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSG 681 ++++ + G A KE+EEL++ + +++E++ ++ SG+ A+ Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ-------------- 1108 Query: 682 FTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEV 741 S A R G ++S L ++ +K +E++ + + +A++ Sbjct: 1109 ----------SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158 Query: 742 NGGSGDAVPSGNEVSENMEEEAENQAESRAAV 773 S G +EE+A+ S++A+ Sbjct: 1159 ERDSALETLQG-----QLEEKAQELGHSQSAL 1185 Score = 37.0 bits (84), Expect = 0.071 Identities = 104/531 (19%), Positives = 203/531 (38%), Gaps = 87/531 (16%) Query: 1 MAMESTATAAVAAELVSADKI-EDVPAPSTSADK-----------------VESLDVDSE 42 + +E T+T A+ +EL+ A + + + A +A+K E L E Sbjct: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405 Query: 43 AKKLLGLGQK----HLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLEL 98 +L+ L QK + A ++ E S+L K +G A E + L E Sbjct: 1406 LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE--------NRGLGER 1457 Query: 99 ARMENGVLGNALEGV---HVEEEEGEKTEDESLVENNDNIDEEAREELRE-QVYDAMGEK 154 A + L L+ +V+E + + E+ + + EA+ RE +V A E Sbjct: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE---VQREAQSTARELEVMTAKYEG 1514 Query: 155 EEAKKTEDKSLAKPETDK-------------EQDSEMEKGGREDMDISKSAEEPQEKVDL 201 + K E++ + E K EQ ++E+ ++ D ++++ Q+K+ Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574 Query: 202 TLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD--------VQEE 253 E+ +EA+ A +A+++ + E + EK+ + D +QE+ Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634 Query: 254 CREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAE--SLDPTVKPV---- 307 R +K+ + + + E+ ++ + T E + T + A+ SL+ V Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694 Query: 308 -DVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEK 366 D+G + + S K L+ + EE ++ + G+ V + Sbjct: 1695 RDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGE 1754 Query: 367 P----GQEAPVLPKDGAVNG----PSVVGDQTPIEPQTSIERLTETKDGSGLE----EKV 414 P Q P PK ++ P Q P+E +S++ L + SG + + Sbjct: 1755 PASPISQRLP--PKVESLESLYFTPIPARSQAPLE--SSLDSLGDVFLDSGRKTRSARRR 1810 Query: 415 RAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ 465 +++ KL VEE ++A +T +P + + A TQ Sbjct: 1811 TTQIINITMTKKLDVEEPDSANSSF------YSTRSAPASQASLRATSSTQ 1855 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 63.5 bits (153), Expect = 7e-10 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166 EEE E +E+ S E ++ + E++ AK T K Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326 Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217 KPE D E SE E+ +K+ + + K E + GA Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386 Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272 AP GP A+ +GK E++ + EE S S + + + G + +E Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445 Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332 P++ + P K G P V VG E + + + E+++ + L Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392 + +V P +SP+V + PG+ P PS + Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543 Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452 + ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+ Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593 Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 VQ+ A E+ + E +E ++ SEE + P + + K+ + Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572 AK+ R T +A A A G + + E+ S + Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627 E E LA T Q + G Q A S+ V+ + QVK Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756 Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687 + +E +E + +E + K++Q N A A +A + + S PG Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812 Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747 ++ + R P+ + + L R A +A+ PE + GS Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870 Query: 748 AVPSGNEVSENMEEEAENQAE 768 +E + EEEAE A+ Sbjct: 871 -----SEEESDSEEEAETLAQ 886 Score = 60.5 bits (145), Expect = 6e-09 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%) Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185 R EL +Y + G A++ +++S LA+P T +Q SE+ + + + Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66 Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245 D + A++ + ++ +E EEA+ A P A S ++P + +EK+ Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126 Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290 + T+ + G+ + ++ + P++ +E TL E++G Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326 +A + ++ S D P+VKP V + P K + + G Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246 Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371 V Q+ G +PPA EE E + E +E+ S V+A ++ + A Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305 Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429 P G P+ G + QT + E + S E S+EET ++ Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359 Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489 +++A+G A ++SP A +T + + G+ E S+ +E+D Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419 Query: 490 TEEMPNDSVLENKSLQ 505 EE P + K+ Q Sbjct: 420 EEEAPAQAKPSGKAPQ 435 Score = 51.6 bits (122), Expect = 3e-06 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%) Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219 T + K E D E SE E D ++ + QEK + TS AKG Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591 Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279 GP +V + KP + ++ EE + E+ + + + KP + Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638 Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339 Q +K T + V PV VG P K T+ + AG + + G Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688 Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390 PAE+S +E AV G S G + PV G P + G Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748 Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450 P Q E+ +++ + A P+Q K SV++++A + + Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806 Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510 S KV AA + Q ++K + + +V Q EE Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866 Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547 + G+ E D + A+ + + + K Q+ AA A K Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904 Score = 48.5 bits (114), Expect = 2e-05 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%) Query: 12 AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70 AA ++ D + S S+++ E + ++ +A L ++ D+P+++ +E A Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125 Query: 71 SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130 +K G+T N GK++ L G+ + Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164 Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184 N + E EE + A + + +ED S + ETD E ++ + Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224 Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241 +S + E P K + + + + KGGA P + KPE+E +EE Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278 Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296 E++ +GT Q + EK Q + + P + + P + Q A + E Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336 Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356 +S + + D + P K + +GK VG PA+ESP A Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390 Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416 PG+ P + K A G Q+ E S E SG +VRA Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476 P++E + +GA P AA Q++ G++ Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471 Query: 477 TEGSEEDDKENDKTEE 492 E S +E+D E Sbjct: 472 EEDSRSSSEESDSDRE 487 Score = 34.3 bits (77), Expect = 0.46 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%) Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425 K ++A + K V+ P + + E + E T + V +PS + Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123 Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466 K E +A G VA + KSP + +AN ET+E Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183 Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521 + + G+ SE+ +D+T E P+ + K+ + +E Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242 Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581 K+ + K L A+ K E S SE ++ EE + Q ++A ++ Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296 Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641 +L + A G + + + E + + S++ ++E Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355 Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698 K LL AK S ++ V A A ES G P G G +V+ + K Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405 Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748 + + SS+ +D + KP ++P+ K+ +K A P G + Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465 Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773 V G E S + EE+++ E+ AA+ Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492 Score = 32.0 bits (71), Expect = 2.3 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%) Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683 QVK A+ K+ EE E E E E+A RS A + S+ + T Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310 Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721 PG G G+ S + KP + + SS+ + S L++ K Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370 Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770 P +ESPRK A P G +G AV E S++ EE++++ E+ Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424 Query: 771 AAVEGTVEA 779 A + + +A Sbjct: 425 AQAKPSGKA 433 Score = 32.0 bits (71), Expect = 2.3 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%) Query: 152 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207 GE EA +KT S K + DK EK G+ + + +EP+E++ Sbjct: 1333 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1385 Query: 208 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267 KG EG +++ S K +++ +++K +++ + K K E Sbjct: 1386 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1435 Query: 268 VSIEEKPKEVSEEQPV 283 ++K K+ + EQ V Sbjct: 1436 SQKKKKKKKKTAEQTV 1451 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 63.5 bits (153), Expect = 7e-10 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166 EEE E +E+ S E ++ + E++ AK T K Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326 Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217 KPE D E SE E+ +K+ + + K E + GA Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386 Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272 AP GP A+ +GK E++ + EE S S + + + G + +E Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445 Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332 P++ + P K G P V VG E + + + E+++ + L Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392 + +V P +SP+V + PG+ P PS + Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543 Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452 + ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+ Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593 Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 VQ+ A E+ + E +E ++ SEE + P + + K+ + Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572 AK+ R T +A A A G + + E+ S + Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627 E E LA T Q + G Q A S+ V+ + QVK Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756 Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687 + +E +E + +E + K++Q N A A +A + + S PG Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812 Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747 ++ + R P+ + + L R A +A+ PE + GS Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870 Query: 748 AVPSGNEVSENMEEEAENQAE 768 +E + EEEAE A+ Sbjct: 871 -----SEEESDSEEEAETLAQ 886 Score = 60.5 bits (145), Expect = 6e-09 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%) Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185 R EL +Y + G A++ +++S LA+P T +Q SE+ + + + Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66 Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245 D + A++ + ++ +E EEA+ A P A S ++P + +EK+ Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126 Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290 + T+ + G+ + ++ + P++ +E TL E++G Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326 +A + ++ S D P+VKP V + P K + + G Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246 Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371 V Q+ G +PPA EE E + E +E+ S V+A ++ + A Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305 Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429 P G P+ G + QT + E + S E S+EET ++ Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359 Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489 +++A+G A ++SP A +T + + G+ E S+ +E+D Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419 Query: 490 TEEMPNDSVLENKSLQ 505 EE P + K+ Q Sbjct: 420 EEEAPAQAKPSGKAPQ 435 Score = 51.6 bits (122), Expect = 3e-06 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%) Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219 T + K E D E SE E D ++ + QEK + TS AKG Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591 Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279 GP +V + KP + ++ EE + E+ + + + KP + Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638 Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339 Q +K T + V PV VG P K T+ + AG + + G Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688 Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390 PAE+S +E AV G S G + PV G P + G Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748 Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450 P Q E+ +++ + A P+Q K SV++++A + + Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806 Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510 S KV AA + Q ++K + + +V Q EE Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866 Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547 + G+ E D + A+ + + + K Q+ AA A K Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904 Score = 48.5 bits (114), Expect = 2e-05 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%) Query: 12 AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70 AA ++ D + S S+++ E + ++ +A L ++ D+P+++ +E A Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125 Query: 71 SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130 +K G+T N GK++ L G+ + Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164 Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184 N + E EE + A + + +ED S + ETD E ++ + Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224 Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241 +S + E P K + + + + KGGA P + KPE+E +EE Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278 Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296 E++ +GT Q + EK Q + + P + + P + Q A + E Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336 Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356 +S + + D + P K + +GK VG PA+ESP A Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390 Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416 PG+ P + K A G Q+ E S E SG +VRA Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476 P++E + +GA P AA Q++ G++ Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471 Query: 477 TEGSEEDDKENDKTEE 492 E S +E+D E Sbjct: 472 EEDSRSSSEESDSDRE 487 Score = 34.3 bits (77), Expect = 0.46 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%) Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425 K ++A + K V+ P + + E + E T + V +PS + Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123 Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466 K E +A G VA + KSP + +AN ET+E Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183 Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521 + + G+ SE+ +D+T E P+ + K+ + +E Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242 Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581 K+ + K L A+ K E S SE ++ EE + Q ++A ++ Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296 Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641 +L + A G + + + E + + S++ ++E Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355 Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698 K LL AK S ++ V A A ES G P G G +V+ + K Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405 Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748 + + SS+ +D + KP ++P+ K+ +K A P G + Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465 Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773 V G E S + EE+++ E+ AA+ Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492 Score = 32.0 bits (71), Expect = 2.3 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%) Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683 QVK A+ K+ EE E E E E+A RS A + S+ + T Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310 Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721 PG G G+ S + KP + + SS+ + S L++ K Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370 Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770 P +ESPRK A P G +G AV E S++ EE++++ E+ Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424 Query: 771 AAVEGTVEA 779 A + + +A Sbjct: 425 AQAKPSGKA 433 Score = 32.0 bits (71), Expect = 2.3 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%) Query: 152 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207 GE EA +KT S K + DK EK G+ + + +EP+E++ Sbjct: 1370 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1422 Query: 208 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267 KG EG +++ S K +++ +++K +++ + K K E Sbjct: 1423 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1472 Query: 268 VSIEEKPKEVSEEQPV 283 ++K K+ + EQ V Sbjct: 1473 SQKKKKKKKKTAEQTV 1488 Score = 30.4 bits (67), Expect = 6.7 Identities = 73/334 (21%), Positives = 122/334 (36%), Gaps = 47/334 (14%) Query: 156 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG 215 +A T K+ A T + SE E ED+ + P + ++ T A Sbjct: 979 QAASTPRKARASESTARSSSSESED---EDVIPATQCLTPGIRTNVV------TMPTAHP 1029 Query: 216 GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK 275 AP+ + A +S K + D ++++ G Q + + + +K Sbjct: 1030 RIAPKA-SMAGASSSKESSRISDGKKQE---GPATQVSKKNPASLPLTQAALKVLAQK-- 1083 Query: 276 EVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG 335 SE QP V + + V+ +L T P+ TS G L + Sbjct: 1084 -ASEAQPPVARTQPSSGVDSAVGTLPAT---------SPQS---TSVQAKGTNKLRKPKL 1130 Query: 336 QEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 395 EV A ++PE + ++ ++S +GSE E P K GP+ +T +E Sbjct: 1131 PEVQQATKAPESSDDSEDSSDSSSGSE----EDGEGPQGAKSAHTLGPTPSRTETLVEET 1186 Query: 396 T--SIERLTETKDGSGLEEKVRAKLVPSQE---------ETKLSVEESEAAGDGVD---- 440 S E S L + L P+ ++ SV + AA D D Sbjct: 1187 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1246 Query: 441 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474 K Q A SP+ + AA+ T ++ + K+G Sbjct: 1247 AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280 >gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo sapiens] Length = 1450 Score = 63.5 bits (153), Expect = 7e-10 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166 EEE E +E+ S E ++ + E++ AK T K Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326 Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217 KPE D E SE E+ +K+ + + K E + GA Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386 Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272 AP GP A+ +GK E++ + EE S S + + + G + +E Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445 Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332 P++ + P K G P V VG E + + + E+++ + L Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392 + +V P +SP+V + PG+ P PS + Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543 Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452 + ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+ Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593 Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 VQ+ A E+ + E +E ++ SEE + P + + K+ + Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572 AK+ R T +A A A G + + E+ S + Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627 E E LA T Q + G Q A S+ V+ + QVK Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756 Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687 + +E +E + +E + K++Q N A A +A + + S PG Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812 Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747 ++ + R P+ + + L R A +A+ PE + GS Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870 Query: 748 AVPSGNEVSENMEEEAENQAE 768 +E + EEEAE A+ Sbjct: 871 -----SEEESDSEEEAETLAQ 886 Score = 60.5 bits (145), Expect = 6e-09 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%) Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185 R EL +Y + G A++ +++S LA+P T +Q SE+ + + + Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66 Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245 D + A++ + ++ +E EEA+ A P A S ++P + +EK+ Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126 Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290 + T+ + G+ + ++ + P++ +E TL E++G Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326 +A + ++ S D P+VKP V + P K + + G Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246 Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371 V Q+ G +PPA EE E + E +E+ S V+A ++ + A Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305 Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429 P G P+ G + QT + E + S E S+EET ++ Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359 Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489 +++A+G A ++SP A +T + + G+ E S+ +E+D Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419 Query: 490 TEEMPNDSVLENKSLQ 505 EE P + K+ Q Sbjct: 420 EEEAPAQAKPSGKAPQ 435 Score = 51.6 bits (122), Expect = 3e-06 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%) Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219 T + K E D E SE E D ++ + QEK + TS AKG Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591 Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279 GP +V + KP + ++ EE + E+ + + + KP + Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638 Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339 Q +K T + V PV VG P K T+ + AG + + G Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688 Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390 PAE+S +E AV G S G + PV G P + G Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748 Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450 P Q E+ +++ + A P+Q K SV++++A + + Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806 Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510 S KV AA + Q ++K + + +V Q EE Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866 Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547 + G+ E D + A+ + + + K Q+ AA A K Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904 Score = 48.5 bits (114), Expect = 2e-05 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%) Query: 12 AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70 AA ++ D + S S+++ E + ++ +A L ++ D+P+++ +E A Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125 Query: 71 SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130 +K G+T N GK++ L G+ + Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164 Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184 N + E EE + A + + +ED S + ETD E ++ + Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224 Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241 +S + E P K + + + + KGGA P + KPE+E +EE Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278 Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296 E++ +GT Q + EK Q + + P + + P + Q A + E Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336 Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356 +S + + D + P K + +GK VG PA+ESP A Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390 Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416 PG+ P + K A G Q+ E S E SG +VRA Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476 P++E + +GA P AA Q++ G++ Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471 Query: 477 TEGSEEDDKENDKTEE 492 E S +E+D E Sbjct: 472 EEDSRSSSEESDSDRE 487 Score = 34.3 bits (77), Expect = 0.46 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%) Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425 K ++A + K V+ P + + E + E T + V +PS + Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123 Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466 K E +A G VA + KSP + +AN ET+E Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183 Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521 + + G+ SE+ +D+T E P+ + K+ + +E Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242 Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581 K+ + K L A+ K E S SE ++ EE + Q ++A ++ Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296 Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641 +L + A G + + + E + + S++ ++E Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355 Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698 K LL AK S ++ V A A ES G P G G +V+ + K Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405 Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748 + + SS+ +D + KP ++P+ K+ +K A P G + Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465 Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773 V G E S + EE+++ E+ AA+ Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492 Score = 32.0 bits (71), Expect = 2.3 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%) Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683 QVK A+ K+ EE E E E E+A RS A + S+ + T Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310 Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721 PG G G+ S + KP + + SS+ + S L++ K Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370 Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770 P +ESPRK A P G +G AV E S++ EE++++ E+ Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424 Query: 771 AAVEGTVEA 779 A + + +A Sbjct: 425 AQAKPSGKA 433 Score = 32.0 bits (71), Expect = 2.3 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%) Query: 152 GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207 GE EA +KT S K + DK EK G+ + + +EP+E++ Sbjct: 1332 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1384 Query: 208 ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267 KG EG +++ S K +++ +++K +++ + K K E Sbjct: 1385 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1434 Query: 268 VSIEEKPKEVSEEQPV 283 ++K K+ + EQ V Sbjct: 1435 SQKKKKKKKKTAEQTV 1450 >gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo sapiens] Length = 958 Score = 63.5 bits (153), Expect = 7e-10 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%) Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166 EEE E +E+ S E ++ + E++ AK T K Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326 Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217 KPE D E SE E+ +K+ + + K E + GA Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386 Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272 AP GP A+ +GK E++ + EE S S + + + G + +E Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445 Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332 P++ + P K G P V VG E + + + E+++ + L Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491 Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392 + +V P +SP+V + PG+ P PS + Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543 Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452 + ++S E +++ DG +V + P+QE++ ++ +++ + A+G +K+ Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593 Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 VQ+ A E+ + E +E ++ SEE + P + + K+ + Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572 AK+ R T +A A A G + + E+ S + Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627 E E LA T Q + G Q A S+ V+ + QVK Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756 Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687 + +E +E + +E + K++Q N A A +A + + S PG Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812 Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747 ++ + R P+ + + L R A +A+ PE + GS Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870 Query: 748 AVPSGNEVSENMEEEAENQAE 768 +E + EEEAE A+ Sbjct: 871 -----SEEESDSEEEAETLAQ 886 Score = 60.5 bits (145), Expect = 6e-09 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%) Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185 R EL +Y + G A++ +++S LA+P T +Q SE+ + + + Sbjct: 7 RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66 Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245 D + A++ + ++ +E EEA+ A P A S ++P + +EK+ Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126 Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290 + T+ + G+ + ++ + P++ +E TL E++G Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186 Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326 +A + ++ S D P+VKP V + P K + + G Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246 Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371 V Q+ G +PPA EE E + E +E+ S V+A ++ + A Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305 Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429 P G P+ G + QT + E + S E S+EET ++ Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359 Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489 +++A+G A ++SP A +T + + G+ E S+ +E+D Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419 Query: 490 TEEMPNDSVLENKSLQ 505 EE P + K+ Q Sbjct: 420 EEEAPAQAKPSGKAPQ 435 Score = 51.6 bits (122), Expect = 3e-06 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%) Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219 T + K E D E SE E D ++ + QEK + TS AKG Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591 Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279 GP +V + KP + ++ EE + E+ + + + KP + Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638 Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339 Q +K T + V PV VG P K T+ + AG + + G Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688 Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390 PAE+S +E AV G S G + PV G P + G Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748 Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450 P Q E+ +++ + A P+Q K SV++++A + + Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806 Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510 S KV AA + Q ++K + + +V Q EE Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866 Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547 + G+ E D + A+ + + + K Q+ AA A K Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904 Score = 48.5 bits (114), Expect = 2e-05 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%) Query: 12 AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70 AA ++ D + S S+++ E + ++ +A L ++ D+P+++ +E A Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125 Query: 71 SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130 +K G+T N GK++ L G+ + Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164 Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184 N + E EE + A + + +ED S + ETD E ++ + Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224 Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241 +S + E P K + + + + KGGA P + KPE+E +EE Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278 Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296 E++ +GT Q + EK Q + + P + + P + Q A + E Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336 Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356 +S + + D + P K + +GK VG PA+ESP A Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390 Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416 PG+ P + K A G Q+ E S E SG +VRA Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476 P++E + +GA P AA Q++ G++ Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471 Query: 477 TEGSEEDDKENDKTEE 492 E S +E+D E Sbjct: 472 EEDSRSSSEESDSDRE 487 Score = 34.3 bits (77), Expect = 0.46 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%) Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425 K ++A + K V+ P + + E + E T + V +PS + Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123 Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466 K E +A G VA + KSP + +AN ET+E Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183 Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521 + + G+ SE+ +D+T E P+ + K+ + +E Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242 Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581 K+ + K L A+ K E S SE ++ EE + Q ++A ++ Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296 Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641 +L + A G + + + E + + S++ ++E Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355 Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698 K LL AK S ++ V A A ES G P G G +V+ + K Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405 Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748 + + SS+ +D + KP ++P+ K+ +K A P G + Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465 Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773 V G E S + EE+++ E+ AA+ Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492 Score = 32.0 bits (71), Expect = 2.3 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%) Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683 QVK A+ K+ EE E E E E+A RS A + S+ + T Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310 Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721 PG G G+ S + KP + + SS+ + S L++ K Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370 Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770 P +ESPRK A P G +G AV E S++ EE++++ E+ Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424 Query: 771 AAVEGTVEA 779 A + + +A Sbjct: 425 AQAKPSGKA 433 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 63.2 bits (152), Expect = 9e-10 Identities = 121/607 (19%), Positives = 249/607 (41%), Gaps = 90/607 (14%) Query: 124 EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR 183 E+++ ++ +EEAR+ L +QV + + KK D L E+ +E ++ K Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK--- 1399 Query: 184 EDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240 D ++ +EK L D L +T ++ + ++ +V S +++ + Sbjct: 1400 ---DAEALSQRLEEKA-LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455 Query: 241 ---EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 297 EEKS+S +E R + ++ +S+ +E E + E+Q + + Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE--EFERQNKQLRADM 1513 Query: 298 ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 357 E L + DVG + E E K LEQ V +E+ E E +A E + + Sbjct: 1514 EDLMSSKD--DVGKN-------VHELEKSKRALEQQV-EEMRTQLEELEDELQATEDAKL 1563 Query: 358 EAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416 + Q E + +D +Q + + I+++ E + E K RA Sbjct: 1564 RLEVNMQAMKAQFERDLQTRD----------EQNEEKKRLLIKQVRELEAELEDERKQRA 1613 Query: 417 KLVPSQEETKLSVEESEA-------AGDGV---------DTKVAQGATEKSPEDKVQIAA 460 V S+++ ++ +++ EA A D V K Q E++ + +I A Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673 Query: 461 NEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----VLENK-- 502 + E++ + E E + EE + + ++ +E+ N + +L+ K Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733 Query: 503 ------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESE 556 L+E EEE N+EL D + + +T A+L A ++ + +S+ Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTL---QVDTLNAELAAERS------AAQKSD 1784 Query: 557 NYVQAVEEFQSCLNLQEQYLEAHDR-----LLAETHYQLGLAYGYNSQYDEAVAQFSKSI 611 N Q +E L + Q LE + ++ ++G Q + A +K + Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844 Query: 612 EVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALK 671 E ++ + QV++ + +YK+++E+ + +++ ++E+A+E N + L+ Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904 Query: 672 ATLVESS 678 L +++ Sbjct: 1905 RELDDAT 1911 Score = 57.8 bits (138), Expect = 4e-08 Identities = 144/741 (19%), Positives = 291/741 (39%), Gaps = 95/741 (12%) Query: 93 KSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREE---LREQVYD 149 K LL++ R E + E + V+E++ T+ E +E + ++ EE L EQ+ Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQ---TKVEGELEEMERKHQQLLEEKNILAEQLQA 898 Query: 150 AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTET 209 EA++ + AK + +E ++E E+ + ++ + ++K+ + L E Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958 Query: 210 SEEAKGGAAPEGPNE--AEVTSGKPEQEVPDAEEEKS--VSGTDVQE----ECREKGGQE 261 +E +G + AE K E+E+ E++ S + + E EC + +E Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018 Query: 262 ------------KQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 309 KQ +I +EE+ K+ EE+ LEK ++ E L + + Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076 Query: 310 GGDEPEEKVVTSENEAGKA----------------VLEQLVGQ--EVPPAEESPEVTTEA 351 DE + ++ E E A V+ +L Q E+ ES + + Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136 Query: 352 AEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLE 411 AE + E+ + L A +Q E + ++E ETK+ Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE--ETKNHEAQI 1194 Query: 412 EKVRAKLVPSQEETKLSVEES-------EAAGDGVDTKVAQGATEKSPEDKVQIAANEET 464 + +R + + EE +E++ E G++T + A E +V+ + + Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254 Query: 465 QEREEQMKE--GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDML 522 ++ + Q++E + +EG + +K ++ N+ L+N S E E+ G ++ A D Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE--LDNVSTLLEEAEKKG-IKFAKDAA 1311 Query: 523 DLAKIIFKRQET-KEAQLYAAQAHLKLGEVSVESENYV-QAVEEFQSCLNLQEQYLEAHD 580 L + QE +E ++ ++ E + Q EE ++ NL++Q L Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371 Query: 581 RLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIE 640 +L A+T ++ G +EA + K E + R+ + E + ++E++ Sbjct: 1372 QL-ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430 Query: 641 ELKELLPEIREKIEDAKESQRSGN---VAELALKATLVESSTSGFTPGGGGSSVSMIASR 697 +L L R+ + ++ Q+ + E ++ A E R Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE-----------------RDR 1473 Query: 698 KPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSE 757 + ++ + + + +EE R++ +A E D + S ++V + Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME--------DLMSSKDDVGK 1525 Query: 758 NMEEEAENQAESRAAVEGTVE 778 N+ E +S+ A+E VE Sbjct: 1526 NVHE----LEKSKRALEQQVE 1542 >gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens] Length = 436 Score = 62.4 bits (150), Expect = 2e-09 Identities = 86/441 (19%), Positives = 177/441 (40%), Gaps = 42/441 (9%) Query: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300 EE ++QEE + + ++ E+ + I+E +++ ++ + L ++G E E + Sbjct: 7 EELKEKNAELQEELQLV--ETEKSEIQLHIKELKRKLETDK--IPLPQEGQVREQEGQVR 62 Query: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360 + + + G E++ E E Q+ QE E+ +V + E E Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQ--EGQVREQE 114 Query: 361 SEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQT-SIERLTETKDGSGLEEKVR 415 +V E+ GQ E V ++G V G E Q E ++G E++ + Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVREQEGQVREQEGQ 172 Query: 416 AKLVPSQ-EETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474 + Q E + V E E + ++ + + +++ E+ E+EEQM++ Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232 Query: 475 EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 534 EE G +E+ + + + + + + Q E+EE M + + + K++E Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE--------QMREQEEQMLKQKEQ 284 Query: 535 KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLG--- 591 E + + ++ E + + + E + + QE+ + + + E Q+ Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344 Query: 592 -LAYGYNSQYDEAVAQFSKSIEVI----------ENRMAVLNEQVKEAEGSSAEYKKEIE 640 + Q E Q K E + E +M EQ+++ E E K+++ Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404 Query: 641 ELKELLPEIREKIEDAKESQR 661 E KE + E E++ + KE R Sbjct: 405 EQKEQMREQEEQMGEQKEQMR 425 Score = 58.2 bits (139), Expect = 3e-08 Identities = 80/421 (19%), Positives = 175/421 (41%), Gaps = 38/421 (9%) Query: 222 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQ 281 P E +V EQE E+E V + Q +E +E++G+V E+ +V E++ Sbjct: 49 PQEGQVR----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQE 100 Query: 282 PVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPA 341 V E++G E E + + + + G E++ E E Q+ QE Sbjct: 101 GQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVR 153 Query: 342 EESPEVTTEAAEASAVEAGSEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQTS 397 E+ +V + E E +V E+ GQ E V ++G + + + Sbjct: 154 EQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211 Query: 398 IERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQ 457 E++ + ++ G +E+ K E + V++ E + ++ + + +++ Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271 Query: 458 IAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNL-E 516 E+ +++EQ ++ E+T EE +E ++ + + E + +EE++G E Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331 Query: 517 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL 576 W+ + + E KE Q++ + ++GE + + + V + + + QE+ + Sbjct: 332 QMWEQKE------QMWEQKE-QMWKQEE--QMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382 Query: 577 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYK 636 + + + Q+G + E + + + + E +M EQ+++ E E K Sbjct: 383 RKQEEQMRKQEEQMG-------EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435 Query: 637 K 637 + Sbjct: 436 E 436 Score = 56.2 bits (134), Expect = 1e-07 Identities = 81/403 (20%), Positives = 168/403 (41%), Gaps = 28/403 (6%) Query: 115 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 174 V E+EG+ E E V + E ++REQ ++ + ++ E + + +EQ Sbjct: 54 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 113 Query: 175 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 234 + ++ + + + E + +V E +G + E EQ Sbjct: 114 EGQVREQEGQVREQEGQVREQEGQV-----------REQEGQVREQEGQVREQEGQVREQ 162 Query: 235 EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 294 E E+E V + + + RE+ GQ ++ E + +E EEQ E+ E Sbjct: 163 EGQVREQEGQV--REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220 Query: 295 VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 354 E + K + G E EE+V E + K EQ+ QE E+ ++ + + Sbjct: 221 QMGEQEEQMRKQEEQMG-EQEEQVQKQEEQVQKQE-EQMRKQEEQMREQEEQMREQEEQM 278 Query: 355 SAVEAGSEVSEKPG-QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-LEE 412 + +E E+ G QE + ++ + + + + E++ E ++ G EE Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMR-------EQEEQMREQEEQMREQEEQMGKQEE 331 Query: 413 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 472 ++ + E+ + ++ E G+ + Q + E++++ E+ +++EEQM+ Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR-KQEEQMRKQEEQMR 390 Query: 473 EGEETEGSEEDDKENDKTEEM--PNDSVLENKSLQENEEEEIG 513 + EE G E+ ++ ++ E+M + + E K +EE +G Sbjct: 391 KQEEQMG-EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432 Score = 50.1 bits (118), Expect = 8e-06 Identities = 67/371 (18%), Positives = 154/371 (41%), Gaps = 25/371 (6%) Query: 115 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 174 V E+EG+ E E V + E ++REQ ++ + ++ E + + +EQ Sbjct: 89 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 148 Query: 175 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 234 + ++ + + + E + +V + E + + G E ++ G+ E+ Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQM--GEQEE 206 Query: 235 EVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293 ++ + EE+ + E+ + QE+Q GE ++++ ++V +++ + KQ + Sbjct: 207 QMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE--QMRKQEEQM 264 Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353 + E + + + ++ E++ T E E E+ + ++ E E E E Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEE 324 Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413 + +K E K+ +G+Q + Q E++ + EE+ Sbjct: 325 QMGKQEEQMWEQK---EQMWEQKEQMWKQEEQMGEQEE-QMQKQEEQVRKQ------EEQ 374 Query: 414 VRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ-EREEQMK 472 +R + +++ + ++ E G+ E+ E K Q+ EE E++EQM+ Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGE---------QKEQMGEQKEQMREQEEQMGEQKEQMR 425 Query: 473 EGEETEGSEED 483 + EE G +++ Sbjct: 426 KQEEHMGEQKE 436 Score = 42.7 bits (99), Expect = 0.001 Identities = 35/172 (20%), Positives = 82/172 (47%), Gaps = 13/172 (7%) Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170 E + +EE+ + E++ L + EE E EQ+ + ++E+ ++ E++ + E Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE---QEEQMREQEEQMREQEEQ 318 Query: 171 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 230 +EQ+ +M K + + + E +E++ W +E + G E + E Sbjct: 319 MREQEEQMGKQEEQMWEQKEQMWEQKEQM-----W----KQEEQMGEQEEQMQKQEEQVR 369 Query: 231 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQ 281 K E+++ EE+ ++++ + G Q++Q GE + E+ +++ E++ Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 62.4 bits (150), Expect = 2e-09 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%) Query: 96 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155 LE + G L+ + EE E + ++ +E E LR QV D K Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511 Query: 156 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214 +A+ E S K E + ++ + E++ + ++ AE + ++ + + E Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274 +A + + ++ + +E+ V+ ++EE + Q+ + E + EE Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628 Query: 275 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331 +E+ Q + + ++AE + ++ +E+ GKA + Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685 Query: 332 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386 +L QE+ + E T + AAE + +E + Q + + + + Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745 Query: 387 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432 Q E + + ++ + L K RA +EE++ + E+S Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799 Query: 433 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483 EAA + A+ + + ED + A E E+ GE T +E Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859 Query: 484 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531 + EN++ + D + + L+E EE + L A D L + ++ Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919 Query: 532 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577 + E ++ A A+ L+LG + +E+ +++ E E ++ Q E Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979 Query: 578 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637 R AE Q LA +EA Q ++E +E L +V+EA ++ Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030 Query: 638 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695 E +L E +K A+E + V E L+ TL + + G A Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085 Query: 696 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755 +R+ + A + V+ +R+ + + ++A++ KQ E A Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134 Query: 756 SENMEEEAENQAESRAAVE 774 +E + +EAE +A RA E Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153 Score = 57.0 bits (136), Expect = 7e-08 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%) Query: 119 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171 + E + LVE+ + EE+ A EK A K E +S A+ Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960 Query: 172 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229 ++ +E+E + + + + E +E+V +L E + + K E E Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015 Query: 230 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287 K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+ Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070 Query: 288 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346 ++ + ++ L + +E EE V +E EA ++ + + + AEE + Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126 Query: 347 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399 +A AE EA E + + E L + D + +QT + + Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186 Query: 400 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459 LT + LEE K + +E +L E +EAA + + E+ ++ Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244 Query: 460 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515 A E + R +++ + T+ EE +K EE SV E L++ EE++ Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304 Query: 516 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572 LA ML K Q +EA A+A L + E++ E +Q +E Q L Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632 E+ L AE QL + S E ++ R+A ++ AE + Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403 Query: 633 AEYKKEIEELKELL 646 ++K+ EE+ E L Sbjct: 2404 QRFRKQAEEIGEKL 2417 Score = 35.0 bits (79), Expect = 0.27 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%) Query: 138 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197 +A EL +Q + E+ + + + +A+ ++ Q + + SAE E Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383 Query: 198 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257 ++ L + ++ A+ A E+ E+ E+ V ++Q + + Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443 Query: 258 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317 E+ E I +E + +++ +E ++ L+ + V+ E L + + ++ Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501 Query: 318 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375 ++ E E KA LEQL EV A++ E + E V+ Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561 Query: 376 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430 + V Q + + E L E LEE+ RA L S+E T V Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621 Query: 431 ESEAAGDGVDTKVAQGATEKSPE 453 ++ +G D + A E PE Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643 Score = 32.7 bits (73), Expect = 1.3 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%) Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 ++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + + Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568 T +AQL + K +V SE+ YV + Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326 Query: 569 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626 L QY++ L + LA ++ E +A+ ++E + ++A + Q K Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385 Query: 627 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661 EA + + K+ I EEL++L EI+ K A+ ++R Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445 Query: 662 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721 S E ++ ++ + GG + + +R A + L +R+ Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502 Query: 722 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768 ++ES RK A+ + K E E A+ + E+ EE E E + Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562 Query: 769 SRAAVEGTVEAGATVE 784 + A+E T + A E Sbjct: 1563 VQVALE-TAQRSAEAE 1577 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 62.4 bits (150), Expect = 2e-09 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%) Query: 96 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155 LE + G L+ + EE E + ++ +E E LR QV D K Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1515 Query: 156 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214 +A+ E S K E + ++ + E++ + ++ AE + ++ + + E Sbjct: 1516 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274 +A + + ++ + +E+ V+ ++EE + Q+ + E + EE Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1632 Query: 275 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331 +E+ Q + + ++AE + ++ +E+ GKA + Sbjct: 1633 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689 Query: 332 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386 +L QE+ + E T + AAE + +E + Q + + + + Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749 Query: 387 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432 Q E + + ++ + L K RA +EE++ + E+S Sbjct: 1750 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1803 Query: 433 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483 EAA + A+ + + ED + A E E+ GE T +E Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863 Query: 484 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531 + EN++ + D + + L+E EE + L A D L + ++ Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923 Query: 532 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577 + E ++ A A+ L+LG + +E+ +++ E E ++ Q E Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983 Query: 578 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637 R AE Q LA +EA Q ++E +E L +V+EA ++ Sbjct: 1984 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2034 Query: 638 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695 E +L E +K A+E + V E L+ TL + + G A Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2089 Query: 696 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755 +R+ + A + V+ +R+ + + ++A++ KQ E A Sbjct: 2090 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2138 Query: 756 SENMEEEAENQAESRAAVE 774 +E + +EAE +A RA E Sbjct: 2139 AEKLRKEAEQEAARRAQAE 2157 Score = 57.0 bits (136), Expect = 7e-08 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%) Query: 119 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171 + E + LVE+ + EE+ A EK A K E +S A+ Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964 Query: 172 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229 ++ +E+E + + + + E +E+V +L E + + K E E Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2019 Query: 230 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287 K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+ Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2074 Query: 288 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346 ++ + ++ L + +E EE V +E EA ++ + + + AEE + Sbjct: 2075 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130 Query: 347 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399 +A AE EA E + + E L + D + +QT + + Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190 Query: 400 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459 LT + LEE K + +E +L E +EAA + + E+ ++ Sbjct: 2191 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248 Query: 460 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515 A E + R +++ + T+ EE +K EE SV E L++ EE++ Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308 Query: 516 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572 LA ML K Q +EA A+A L + E++ E +Q +E Q L Sbjct: 2309 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2362 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632 E+ L AE QL + S E ++ R+A ++ AE + Sbjct: 2363 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2407 Query: 633 AEYKKEIEELKELL 646 ++K+ EE+ E L Sbjct: 2408 QRFRKQAEEIGEKL 2421 Score = 35.0 bits (79), Expect = 0.27 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%) Query: 138 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197 +A EL +Q + E+ + + + +A+ ++ Q + + SAE E Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2387 Query: 198 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257 ++ L + ++ A+ A E+ E+ E+ V ++Q + + Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447 Query: 258 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317 E+ E I +E + +++ +E ++ L+ + V+ E L + + ++ Sbjct: 2448 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2505 Query: 318 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375 ++ E E KA LEQL EV A++ E + E V+ Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565 Query: 376 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430 + V Q + + E L E LEE+ RA L S+E T V Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625 Query: 431 ESEAAGDGVDTKVAQGATEKSPE 453 ++ +G D + A E PE Sbjct: 2626 ATKTLPNGRDA-LDGPAAEAEPE 2647 Score = 32.7 bits (73), Expect = 1.3 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%) Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 ++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + + Sbjct: 1234 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1291 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568 T +AQL + K +V SE+ YV + Sbjct: 1292 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330 Query: 569 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626 L QY++ L + LA ++ E +A+ ++E + ++A + Q K Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1389 Query: 627 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661 EA + + K+ I EEL++L EI+ K A+ ++R Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449 Query: 662 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721 S E ++ ++ + GG + + +R A + L +R+ Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1506 Query: 722 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768 ++ES RK A+ + K E E A+ + E+ EE E E + Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566 Query: 769 SRAAVEGTVEAGATVE 784 + A+E T + A E Sbjct: 1567 VQVALE-TAQRSAEAE 1581 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 62.4 bits (150), Expect = 2e-09 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%) Query: 96 LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155 LE + G L+ + EE E + ++ +E E LR QV D K Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511 Query: 156 EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214 +A+ E S K E + ++ + E++ + ++ AE + ++ + + E Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570 Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274 +A + + ++ + +E+ V+ ++EE + Q+ + E + EE Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628 Query: 275 KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331 +E+ Q + + ++AE + ++ +E+ GKA + Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685 Query: 332 --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386 +L QE+ + E T + AAE + +E + Q + + + + Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745 Query: 387 GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432 Q E + + ++ + L K RA +EE++ + E+S Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799 Query: 433 --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483 EAA + A+ + + ED + A E E+ GE T +E Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859 Query: 484 DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531 + EN++ + D + + L+E EE + L A D L + ++ Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919 Query: 532 QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577 + E ++ A A+ L+LG + +E+ +++ E E ++ Q E Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979 Query: 578 AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637 R AE Q LA +EA Q ++E +E L +V+EA ++ Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030 Query: 638 EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695 E +L E +K A+E + V E L+ TL + + G A Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085 Query: 696 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755 +R+ + A + V+ +R+ + + ++A++ KQ E A Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134 Query: 756 SENMEEEAENQAESRAAVE 774 +E + +EAE +A RA E Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153 Score = 57.0 bits (136), Expect = 7e-08 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%) Query: 119 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171 + E + LVE+ + EE+ A EK A K E +S A+ Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960 Query: 172 KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229 ++ +E+E + + + + E +E+V +L E + + K E E Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015 Query: 230 GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287 K E+ + + E++S + +E +K Q ++ ++++K +E+ + TL+ Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070 Query: 288 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346 ++ + ++ L + +E EE V +E EA ++ + + + AEE + Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126 Query: 347 VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399 +A AE EA E + + E L + D + +QT + + Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186 Query: 400 RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459 LT + LEE K + +E +L E +EAA + + E+ ++ Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244 Query: 460 ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515 A E + R +++ + T+ EE +K EE SV E L++ EE++ Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304 Query: 516 E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572 LA ML K Q +EA A+A L + E++ E +Q +E Q L Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358 Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632 E+ L AE QL + S E ++ R+A ++ AE + Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403 Query: 633 AEYKKEIEELKELL 646 ++K+ EE+ E L Sbjct: 2404 QRFRKQAEEIGEKL 2417 Score = 35.0 bits (79), Expect = 0.27 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%) Query: 138 EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197 +A EL +Q + E+ + + + +A+ ++ Q + + SAE E Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383 Query: 198 KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257 ++ L + ++ A+ A E+ E+ E+ V ++Q + + Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443 Query: 258 GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317 E+ E I +E + +++ +E ++ L+ + V+ E L + + ++ Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501 Query: 318 VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375 ++ E E KA LEQL EV A++ E + E V+ Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561 Query: 376 KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430 + V Q + + E L E LEE+ RA L S+E T V Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621 Query: 431 ESEAAGDGVDTKVAQGATEKSPE 453 ++ +G D + A E PE Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643 Score = 32.7 bits (73), Expect = 1.3 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%) Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512 ++++Q ++Q EQ+++ E EE ++ +K EE + ++++ E + + Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287 Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568 T +AQL + K +V SE+ YV + Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326 Query: 569 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626 L QY++ L + LA ++ E +A+ ++E + ++A + Q K Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385 Query: 627 --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661 EA + + K+ I EEL++L EI+ K A+ ++R Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445 Query: 662 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721 S E ++ ++ + GG + + +R A + L +R+ Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502 Query: 722 PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768 ++ES RK A+ + K E E A+ + E+ EE E E + Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562 Query: 769 SRAAVEGTVEAGATVE 784 + A+E T + A E Sbjct: 1563 VQVALE-TAQRSAEAE 1577 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.299 0.121 0.312 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,198,424 Number of Sequences: 37866 Number of extensions: 1585538 Number of successful extensions: 23899 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 414 Number of HSP's successfully gapped in prelim test: 1388 Number of HSP's that attempted gapping in prelim test: 9241 Number of HSP's gapped (non-prelim): 9254 length of query: 788 length of database: 18,247,518 effective HSP length: 110 effective length of query: 678 effective length of database: 14,082,258 effective search space: 9547770924 effective search space used: 9547770924 T: 11 A: 40 X1: 17 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 43 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.