Guide to the Human Genome
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Search of human proteins with 27262628

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
sapiens]
         (788 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ...  1520   0.0  
gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ...  1456   0.0  
gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo ...   610   e-174
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    94   4e-19
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    94   6e-19
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    94   6e-19
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              92   2e-18
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       75   2e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     74   7e-13
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    73   9e-13
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          72   2e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    72   3e-12
gi|16262452 cingulin [Homo sapiens]                                    70   6e-12
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...    68   3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     67   8e-11
gi|104526627 triadin [Homo sapiens]                                    67   8e-11
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       66   1e-10
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    65   2e-10
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    65   2e-10
gi|210032580 SET domain containing 1B [Homo sapiens]                   65   3e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         64   4e-10
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    64   7e-10
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    64   7e-10
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    64   7e-10
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    64   7e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    63   9e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    62   2e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        62   2e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        62   2e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         62   2e-09

>gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
           sapiens]
          Length = 788

 Score = 1520 bits (3935), Expect = 0.0
 Identities = 788/788 (100%), Positives = 788/788 (100%)

Query: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60
           MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP
Sbjct: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60

Query: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120
           AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG
Sbjct: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120

Query: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180
           EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK
Sbjct: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180

Query: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240
           GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE
Sbjct: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240

Query: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300
           EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL
Sbjct: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300

Query: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360
           DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG
Sbjct: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360

Query: 361 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP 420
           SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP
Sbjct: 361 SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP 420

Query: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS 480
           SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS
Sbjct: 421 SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS 480

Query: 481 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 540
           EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY
Sbjct: 481 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 540

Query: 541 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY 600
           AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY
Sbjct: 541 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY 600

Query: 601 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 660
           DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ
Sbjct: 601 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 660

Query: 661 RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR 720
           RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR
Sbjct: 661 RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR 720

Query: 721 KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG 780
           KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG
Sbjct: 721 KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG 780

Query: 781 ATVESTAC 788
           ATVESTAC
Sbjct: 781 ATVESTAC 788


>gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
           sapiens]
          Length = 790

 Score = 1456 bits (3770), Expect = 0.0
 Identities = 752/757 (99%), Positives = 755/757 (99%)

Query: 32  DKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 91
           +++  LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY
Sbjct: 34  NRIIHLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 93

Query: 92  GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 151
           GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM
Sbjct: 94  GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 153

Query: 152 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 211
           GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE
Sbjct: 154 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 213

Query: 212 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 271
           EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE
Sbjct: 214 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE 273

Query: 272 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 331
           EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE
Sbjct: 274 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE 333

Query: 332 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 391
           QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP
Sbjct: 334 QLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTP 393

Query: 392 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 451
           IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS
Sbjct: 394 IEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS 453

Query: 452 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 511
           PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE
Sbjct: 454 PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513

Query: 512 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 571
           IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL
Sbjct: 514 IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 573

Query: 572 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 631
           QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS
Sbjct: 574 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 633

Query: 632 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 691
           SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV
Sbjct: 634 SAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSV 693

Query: 692 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 751
           SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS
Sbjct: 694 SMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPS 753

Query: 752 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788
           GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 754 GNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 790


>gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo
           sapiens]
          Length = 449

 Score =  610 bits (1574), Expect = e-174
 Identities = 341/468 (72%), Positives = 366/468 (78%), Gaps = 23/468 (4%)

Query: 322 ENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVN 381
           E+ A  AV  +LV  +    E+ P  +T A +  +++  SE  +  G     L       
Sbjct: 4   ESTATAAVAAELVSAD--KIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHL------- 54

Query: 382 GPSVVGD-QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVD 440
              V+GD    +        L   K G    E   A     +   +L+  E+   G+ ++
Sbjct: 55  ---VMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALE 111

Query: 441 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500
               +    +  ED+  +  N+            +ETEGSEEDDKENDKTEEMPNDSVLE
Sbjct: 112 GVHVEEEEGEKTEDESLVENNDNI----------DETEGSEEDDKENDKTEEMPNDSVLE 161

Query: 501 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 560
           NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ
Sbjct: 162 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221

Query: 561 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 620
           AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV
Sbjct: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281

Query: 621 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 680
           LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS
Sbjct: 282 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 341

Query: 681 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 740
           GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE
Sbjct: 342 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 401

Query: 741 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788
           VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 402 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 449



 Score =  280 bits (717), Expect = 3e-75
 Identities = 208/493 (42%), Positives = 273/493 (55%), Gaps = 49/493 (9%)

Query: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60
           MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP
Sbjct: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60

Query: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120
           AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG
Sbjct: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120

Query: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180
           EKTEDESLVENNDNIDE    E  ++  D   E       E+KSL + E ++  + E+  
Sbjct: 121 EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL-- 178

Query: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240
              + +D++K   + QE            ++EA+  AA       EV S + E  V   E
Sbjct: 179 -AWDMLDLAKIIFKRQE------------TKEAQLYAAQAHLKLGEV-SVESENYVQAVE 224

Query: 241 EEKSVSGTDVQE-ECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAES 299
           E +S      Q  E  ++   E   ++ ++     +    ++ V    K    +E     
Sbjct: 225 EFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQ---YDEAVAQFSKSIEVIENRMAV 281

Query: 300 LDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEA 359
           L+  VK  + G     +K +    E    + E++  ++   ++ S  V   A +A+ VE+
Sbjct: 282 LNEQVKEAE-GSSAEYKKEIEELKELLPEIREKI--EDAKESQRSGNVAELALKATLVES 338

Query: 360 GSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLV 419
            S     PG         G  +  S++  + P +  +S   +T+      +   VR K  
Sbjct: 339 -STSGFTPG---------GGGSSVSMIASRKPTDGASSSNCVTD------ISHLVRKKRK 382

Query: 420 PSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEG 479
           P +E    S  + +A     + +V  G+ +  P      + NE ++  EE+ +   E+  
Sbjct: 383 PEEE----SPRKDDAKKAKQEPEVNGGSGDAVP------SGNEVSENMEEEAENQAESRA 432

Query: 480 SEEDDKENDKTEE 492
           + E   E   T E
Sbjct: 433 AVEGTVEAGATVE 445


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 104/404 (25%), Positives = 168/404 (41%), Gaps = 34/404 (8%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175
            E+EE +K + E   E      E+  ++ R Q  +  GE+E  +  E++   + E +KE +
Sbjct: 698  EKEEWKKRDGE---EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754

Query: 176  SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGA-APEGPNEAEVTSGKPEQ 234
             + E+G  E+++  +  EE + K +          +E KG     +G  E E T G+ E+
Sbjct: 755  GK-EEGEGEEVEGEREKEEGERKKE------ERAGKEEKGEEEGDQGEGEEEETEGRGEE 807

Query: 235  EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 294
            +    EE   V G +V+E   E+  +E++GE             EE+     E++G   E
Sbjct: 808  K----EEGGEVEGGEVEEGKGEREEEEEEGE------------GEEEEGEGEEEEGEGEE 851

Query: 295  VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 354
             E E           G +E EE     E E G+   E+    E    E   E   E    
Sbjct: 852  EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911

Query: 355  SAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKV 414
               E G    E+ G+E     ++    G    G+    E +   E   E  +G G EE  
Sbjct: 912  GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG- 970

Query: 415  RAKLVPSQEETKLSVEESEAAGDGVDTK-VAQGATEKSPEDKVQIAANEETQEREEQMKE 473
                    EE +   EE E  G+G + +   +G  E   E++ +    EE +   E   E
Sbjct: 971  ----EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026

Query: 474  GEETEGSEEDDKENDKTEEMPNDSV-LENKSLQENEEEEIGNLE 516
            GEE EG  E+++  ++ EE   +    EN+  +E EEEE G  +
Sbjct: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 113/442 (25%), Positives = 174/442 (39%), Gaps = 54/442 (12%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEA-REELREQVYDAMGEKEEAKKTEDKSLAKPETDKE- 173
            E+ +G   E++ +  N +N+     R+E  E + D + +K E  + + KS+ + E   E 
Sbjct: 594  EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEG 653

Query: 174  ----------------QDSEMEKG----GREDMDISKSAE--------------EPQEKV 199
                            QD E EKG    GR +M+     E              E QE+ 
Sbjct: 654  RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713

Query: 200  DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGG 259
            +       E ++E + G   E     E    + E+E  + E ++   G +V+ E  ++ G
Sbjct: 714  EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773

Query: 260  QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVV 319
            + K+ E     EEK +E  ++      E +G   E E E  +     V+ G  E EE   
Sbjct: 774  ERKK-EERAGKEEKGEEEGDQGEGEEEETEGRGEEKE-EGGEVEGGEVEEGKGEREE--- 828

Query: 320  TSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE-VSEKPGQEAPVLPKDG 378
              E E G+   E+  G+     EE  E   E  E    E G E   E+ G+E     ++ 
Sbjct: 829  --EEEEGEGEEEEGEGE-----EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881

Query: 379  AVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDG 438
               G      +   E +       E  +G G EE+   K     EE +   EE E  G+G
Sbjct: 882  EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941

Query: 439  VD----TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494
             D     +  +G  E   E+       E   E EE   EGEE EG  E ++E  + EE  
Sbjct: 942  EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGE 1000

Query: 495  NDSVLENKSLQENEEEEIGNLE 516
             +   E +   E EEEE G +E
Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVE 1022



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 106/376 (28%), Positives = 153/376 (40%), Gaps = 53/376 (14%)

Query: 111  EGVHVEEEEGEKTEDESLVENNDNIDEE--AREELREQVYDAMGEKEEAKKTEDKSLAKP 168
            EG   EE EGE+ E E   E  +   EE   +EE  E+  D  GE EE ++TE +   K 
Sbjct: 752  EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD-QGEGEE-EETEGRGEEKE 809

Query: 169  ETDKEQDSEME--KGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG---GAAPEGPN 223
            E  + +  E+E  KG RE+ +     EE + + +       E   E KG   G   EG  
Sbjct: 810  EGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE 869

Query: 224  EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 283
            E E   G+ E+E  + E E+   G   +EE   +G +E +GE     EE+  E   E+  
Sbjct: 870  EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG----EEEEGEGKGEEEG 925

Query: 284  VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL---VGQEVPP 340
               E +G   E E E  D        G  E EE     E E G+   E+     G+E   
Sbjct: 926  EEGEGEGEEEEGEGEGEDGE------GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979

Query: 341  AEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIER 400
              E  E   E  E    E G E  E  G+E      +G   G          E +  +E 
Sbjct: 980  EGEEEEGEGEGEEEEGEEEGEEEGE--GEE------EGEGEGEE--------EEEGEVEG 1023

Query: 401  LTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAA 460
              E ++G G  E         +EE +   EE E  G+G + +          E++ +   
Sbjct: 1024 EVEGEEGEGEGE---------EEEGEEEGEEREKEGEGEENR------RNREEEEEEEGK 1068

Query: 461  NEETQEREEQMKEGEE 476
             +ET E E + ++GEE
Sbjct: 1069 YQETGEEENERQDGEE 1084



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 106/450 (23%), Positives = 177/450 (39%), Gaps = 65/450 (14%)

Query: 120 GEKTEDESLVENNDNIDEEAREELRE------QVYDAMGEKEEAKKTE---DKSLAKPET 170
           GE T+D +L EN+D+ + E   E++E       V   +   + A   E   D+ +  PE 
Sbjct: 530 GELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPE- 588

Query: 171 DKEQDSEMEKGGREDMDISKSAEE------PQEKVDLTLDWLTETSEEAKG--------- 215
           +KE   + +  G E+ ++  + E        +EK ++  D LT+ +E ++G         
Sbjct: 589 EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAE 648

Query: 216 --------GAAPEGPNEAE-------------------VTSGKPEQEVPDAEEEKSVSGT 248
                   G   EG + AE                      G+ E+E+ + EE K   G 
Sbjct: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708

Query: 249 DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVD 308
           + +++ RE+G Q+++ + +    E+     EE+     E++    E + E     V+   
Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE--- 765

Query: 309 VGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPG 368
            G  E EE     E  AGK    +  G +    EE  E   E  E      G EV E  G
Sbjct: 766 -GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824

Query: 369 QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS 428
            E     ++G        G++   E +       E  +G G EE    +     EE +  
Sbjct: 825 -EREEEEEEGEGEEEEGEGEEEEGEGE------EEEGEGKGEEEGEEGEGEEEGEEGEGE 877

Query: 429 VEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQM--KEGEETEGSEEDDKE 486
            EE E  G+G +    +G  E+   +  +    E  +E  E    +EGEE EG  E+++ 
Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937

Query: 487 NDKTEEMPNDSVLENKSLQENEEEEIGNLE 516
             + E+   +   E    +  EEE  G  E
Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 74/269 (27%), Positives = 108/269 (40%), Gaps = 34/269 (12%)

Query: 107  GNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA 166
            G  +EG  VEE +GE+ E+E   E  +  +EE             GE+EE +  E++   
Sbjct: 811  GGEVEGGEVEEGKGEREEEE---EEGEGEEEEGE-----------GEEEEGEGEEEEGEG 856

Query: 167  KPETDKEQDSEMEKG------GREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPE 220
            K E + E+    E+G      G E+    +  EE + + +       E   E +G    E
Sbjct: 857  KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE-------EEEGEGEGEEEGE 909

Query: 221  GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEE 280
            G  E E   GK E+E  + E E      + + E  E  G+E++GE     EE   E  EE
Sbjct: 910  GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969

Query: 281  QPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP 340
                  E +G   E E E      +  + G +E E +      E G+   E+    EV  
Sbjct: 970  GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE------EEGEGEGEEEEEGEVEG 1023

Query: 341  AEESPEVTTEAAEASAVEAGSEVSEKPGQ 369
              E  E   E  E    E G E  EK G+
Sbjct: 1024 EVEGEEGEGEGEEEEGEEEGEE-REKEGE 1051



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 86/338 (25%), Positives = 141/338 (41%), Gaps = 39/338 (11%)

Query: 92   GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEE------AREELRE 145
            G+   E   +E G +         EEEEGE  E+E   E  +   EE        EE  E
Sbjct: 805  GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864

Query: 146  QVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMDISKSAEEPQEKVDLT 202
               +  GE+ E +  E++   + E + E + E E+G   G E+ +     EE + K +  
Sbjct: 865  GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE-- 922

Query: 203  LDWLTETSEEAKG-GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKG--- 258
                 E  EE +G G   EG  E E   G+ E+E  + E E+     + +EE   +G   
Sbjct: 923  -----EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977

Query: 259  ---GQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPE 315
               G+E++GE     EE+ +E  EE+     E +G   E E   ++  V+  +  G+  E
Sbjct: 978  EGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE 1036

Query: 316  EKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375
            E+      E G+   ++  G+E     E      E  E    E G E +E+  Q+     
Sbjct: 1037 EE----GEEEGEEREKEGEGEENRRNREE----EEEEEGKYQETGEEENER--QDGEEYK 1086

Query: 376  KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413
            K   + G    G     + ++    +T T+ G+G E++
Sbjct: 1087 KVSKIKGSVKYGKHKTYQKKS----VTNTQ-GNGKEQR 1119



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 25/96 (26%), Positives = 37/96 (38%), Gaps = 5/96 (5%)

Query: 684 PGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEE----ESPRKDDAKKAKQEP 739
           PG G   ++     K  DG        +  H   + ++ EE    E    ++ +  ++E 
Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748

Query: 740 EVNGGSGDAVPSGNEVSENME-EEAENQAESRAAVE 774
           E   G G     G EV    E EE E + E RA  E
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)

Query: 100 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 154
           ++++  +   +E   VE+E+ E  E      E L  +     +EA EE +E+  +A  E+
Sbjct: 447 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 505

Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
             AKK+  K+ A PE  +E+  + E+ G+E+ +                    E  E AK
Sbjct: 506 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 544

Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 271
              A EG +E E +S K E E  + E E    G + + +  EK  +EK  EV    E   
Sbjct: 545 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 603

Query: 272 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 322
               EKP++     P   +E++G +      VE +   P  K PV+  G  P  K    E
Sbjct: 604 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 663

Query: 323 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 377
              +   K+ +E+     VP  P EE+             E   EV E P +E     ++
Sbjct: 664 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 723

Query: 378 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 436
              + P     ++P++ +   E +T TK     LE++ + +  P Q+E     E+ +A G
Sbjct: 724 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 779

Query: 437 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 496
           +G   +       K    K  IA N E + +EE  +E +E +GS  ++++   T  +   
Sbjct: 780 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 837

Query: 497 SVLENKSLQENEEEEI 512
              E K   ++EE+ +
Sbjct: 838 PADEKKGGDKSEEKVV 853



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)

Query: 97  ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156
           E+A  ++ V   A E   V+EEEGEK E+E   E  +  DE A+ +   Q  +   EKE 
Sbjct: 505 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 557

Query: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 215
           + + E+    + ET+ E + E E   +E+  + + +EE   K +L  D   E  E+AK  
Sbjct: 558 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616

Query: 216 ------------------------------------------------GAAP--EGPNEA 225
                                                           G +P  + P E 
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676

Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285
           +  S  P+  V +A+ +  V   + +EE  ++  +  + E +   EEKPK+V E++    
Sbjct: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 732

Query: 286 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 345
                     +AES      PV    +E   +VVT   ++ K  LE+   +E  P ++  
Sbjct: 733 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 772

Query: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 405
           E      E  + E GS+   K  ++     +D AVNG         +E +  +E+ T+ K
Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 819

Query: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 464
            GSG EE+             LS  + +  GD  + KV    T EK   +    A    T
Sbjct: 820 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 874

Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500
           +      K  E  E  EE      K E++ + ++++
Sbjct: 875 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 910



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 424
           P +     +  P V   +  ++ +   E + ETK   + S +EE + A      V  +EE
Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 487

Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 484
            K + EE E   +  + +VA    +KSP         EE  E+EE+  EG+E E  EE+D
Sbjct: 488 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 540

Query: 485 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 542
           +  ++D+ EE    S  E  S +E  E+E G  E        A+   +  E KE      
Sbjct: 541 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 584

Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 602
                  E  VE ++   A +E        E+  +A   +      + G +    S  +E
Sbjct: 585 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637

Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 662
                     V E   + + +   E +G S   K  +EE K   P  +  +E+AK     
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 696

Query: 663 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 722
           G   +   +   V+ +               +  +K  +       V ++   + K  K 
Sbjct: 697 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 755

Query: 723 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 782
             E   K++ K  +QE E     G+    G    E  ++ A+   +   AV G VE    
Sbjct: 756 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 811

Query: 783 VE 784
           VE
Sbjct: 812 VE 813



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)

Query: 365 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 424
           +KP  EAP L          +   +   E     E LT   +   +  K   K    ++E
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496

Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 472
            +   EE E A      K      ++   +K +    EE +E +E  K            
Sbjct: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556

Query: 473 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 520
                 EGE+ EG  E + E ++ E        E K ++E  EE     EL  D
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 604



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 78/437 (17%), Positives = 162/437 (37%), Gaps = 59/437 (13%)

Query: 388 DQTPIEPQTSIERLTETK-----DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK 442
           DQ   E + ++E +   K     D   LEE +       +EE +L  +++EAA   +   
Sbjct: 151 DQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLR-DDTEAAIRALRKD 209

Query: 443 VAQGATEKSPEDKVQIAANEE-----TQEREEQMKEGEETEGSEEDDKENDKTEEMPNDS 497
           + + +  K   DK   +  +E     +   EE      + + S    +  D  +   + +
Sbjct: 210 IEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTA 269

Query: 498 VLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA------QLYAAQAHLKLGEV 551
           + E +S  E+  ++  +    W     AK+    ++ KEA      ++   +  L+   +
Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSI 329

Query: 552 SVES--------ENYVQAVEE--------FQSCLNLQEQYLEAHDRLLAETHYQLGLAYG 595
            +ES        E  +  +EE        +Q  +   E  L      +A    +      
Sbjct: 330 ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLN 389

Query: 596 YNSQYDEAVAQFSKSIEVIENRMAV-----------------LNEQVKEAEGSSAEYKKE 638
                D  +A + K +E  E R +                  ++ ++++ +  + + K +
Sbjct: 390 VKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQ 449

Query: 639 IEELKELLPEIREKIEDAKESQRSGNVA---ELALKATLVESSTSGFTPGGGGSSVSMIA 695
            + ++E++ E   K+ED K        A   ELA+     +   +        +    +A
Sbjct: 450 HKFVEEIIEET--KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA 507

Query: 696 SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755
           ++K    A++     ++     +K + E +   +++ + AK +    GGS     S  E 
Sbjct: 508 AKKSPVKATAP----EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 756 SENMEEEAENQAESRAA 772
            E  E E E +AE   A
Sbjct: 564 GEQEEGETEAEAEGEEA 580


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)

Query: 100 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 154
           ++++  +   +E   VE+E+ E  E      E L  +     +EA EE +E+  +A  E+
Sbjct: 71  KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 129

Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
             AKK+  K+ A PE  +E+  + E+ G+E+ +                    E  E AK
Sbjct: 130 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 168

Query: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 271
              A EG +E E +S K E E  + E E    G + + +  EK  +EK  EV    E   
Sbjct: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 227

Query: 272 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 322
               EKP++     P   +E++G +      VE +   P  K PV+  G  P  K    E
Sbjct: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287

Query: 323 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 377
              +   K+ +E+     VP  P EE+             E   EV E P +E     ++
Sbjct: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347

Query: 378 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 436
              + P     ++P++ +   E +T TK     LE++ + +  P Q+E     E+ +A G
Sbjct: 348 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 403

Query: 437 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 496
           +G   +       K    K  IA N E + +EE  +E +E +GS  ++++   T  +   
Sbjct: 404 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 461

Query: 497 SVLENKSLQENEEEEI 512
              E K   ++EE+ +
Sbjct: 462 PADEKKGGDKSEEKVV 477



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)

Query: 97  ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156
           E+A  ++ V   A E   V+EEEGEK E+E   E  +  DE A+ +   Q  +   EKE 
Sbjct: 129 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 181

Query: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 215
           + + E+    + ET+ E + E E   +E+  + + +EE   K +L  D   E  E+AK  
Sbjct: 182 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240

Query: 216 ------------------------------------------------GAAP--EGPNEA 225
                                                           G +P  + P E 
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300

Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285
           +  S  P+  V +A+ +  V   + +EE  ++  +  + E +   EEKPK+V E++    
Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 356

Query: 286 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 345
                     +AES      PV    +E   +VVT   ++ K  LE+   +E  P ++  
Sbjct: 357 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 396

Query: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 405
           E      E  + E GS+   K  ++     +D AVNG         +E +  +E+ T+ K
Sbjct: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 443

Query: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 464
            GSG EE+             LS  + +  GD  + KV    T EK   +    A    T
Sbjct: 444 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498

Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500
           +      K  E  E  EE      K E++ + ++++
Sbjct: 499 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 424
           P +     +  P V   +  ++ +   E + ETK   + S +EE + A      V  +EE
Sbjct: 52  PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111

Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 484
            K + EE E   +  + +VA    +KSP         EE  E+EE+  EG+E E  EE+D
Sbjct: 112 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 164

Query: 485 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 542
           +  ++D+ EE    S  E  S +E  E+E G  E        A+   +  E KE      
Sbjct: 165 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 208

Query: 543 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 602
                  E  VE ++   A +E        E+  +A   +      + G +    S  +E
Sbjct: 209 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261

Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 662
                     V E   + + +   E +G S   K  +EE K   P  +  +E+AK     
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 320

Query: 663 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 722
           G   +   +   V+ +               +  +K  +       V ++   + K  K 
Sbjct: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 379

Query: 723 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 782
             E   K++ K  +QE E     G+    G    E  ++ A+   +   AV G VE    
Sbjct: 380 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435

Query: 783 VE 784
           VE
Sbjct: 436 VE 437



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)

Query: 365 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 424
           +KP  EAP L          +   +   E     E LT   +   +  K   K    ++E
Sbjct: 61  QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120

Query: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 472
            +   EE E A      K      ++   +K +    EE +E +E  K            
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180

Query: 473 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 520
                 EGE+ EG  E + E ++ E        E K ++E  EE     EL  D
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 228


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 109/437 (24%), Positives = 179/437 (40%), Gaps = 57/437 (13%)

Query: 111  EGVHVEEEEGE--KTEDESLVENNDNIDEEAREELR---------EQVYDAMGEKEEAKK 159
            EGV   E EG+  + E E+  E+ D    EA  E +         E  ++   E E A+ 
Sbjct: 1849 EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEA 1908

Query: 160  TEDKSLAKPETDK------EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213
             E +  A+PET+       E + E E  G E  +  ++A+E + +     + +   S+EA
Sbjct: 1909 PEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE--SQEA 1966

Query: 214  KGGAAPEGPN----EAEVTSGKPEQEV-PDAEEEKSVSGTDVQEECREKGGQEKQGEVIV 268
            +  A PE  +    E EV + + E E  P++E+ ++       +E  E+   E  G    
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG---- 2022

Query: 269  SIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKA 328
             +E +PK   EE   V  E Q T  + + ES        +    E E +V  +E EA   
Sbjct: 2023 -VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081

Query: 329  V----LEQLVGQEVPPAE--ESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNG 382
                  ++  G+  P +E  E+PE   EA +A  +EA       P  E    P+   +  
Sbjct: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA-------PETEGEAQPESEGIEA 2134

Query: 383  PSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLS-VEESEAAGD---- 437
            P   G+  P      +E      +     E + A+    + + +L  VE  EA G+    
Sbjct: 2135 PEAEGEAQP--ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192

Query: 438  --GVDTKVAQGATEKSPE-DKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494
              G++   A+G  E  PE + V+    EE  + E +  E  E EG  + + E +   E  
Sbjct: 2193 SEGIEAPEAEG--EAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250

Query: 495  NDSVLENKSLQENEEEE 511
                +   SL + + EE
Sbjct: 2251 GSPQV---SLGDGQSEE 2264



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 164/797 (20%), Positives = 287/797 (36%), Gaps = 98/797 (12%)

Query: 21   IEDVPAPSTS--------ADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL 72
            +ED PA ST+        A+  E    ++  +K +        MG     +    +   +
Sbjct: 1633 LEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQI 1692

Query: 73   LGKKYGE-TANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVEN 131
            L +K GE T  E  E       +     R   G  G    G+     +G   ++    E 
Sbjct: 1693 LQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGL----SQGPGVDEGEDGEG 1748

Query: 132  NDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET-DKEQDSE-MEKGGREDMDIS 189
            +  ++ +   +L E   DAM ++ E K    ++ A  E  + EQ+ E + + G      S
Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808

Query: 190  KSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249
               +  Q +     D     S+ A+G  APE   EA+  S     E P+AE +   +  +
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES--EGVEAPEAEGDAQEAEGE 1866

Query: 250  VQEECREKGGQEKQGEVIVSIE--EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPV 307
             Q E  +    E +GE     E  E P+   E QP    E +G       +   P  + V
Sbjct: 1867 AQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQP----ESEGAEAPEAEKEAQPETESV 1922

Query: 308  DV----GGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAE--ESPEVTTEAA-EASAVEAG 360
            +     G DEPE +   +E +  +   ++  GQ  P +E  ES E   EA  E+  VEA 
Sbjct: 1923 EALETEGEDEPESE--GAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980

Query: 361  SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTS-------------------IERL 401
                E    E    P+   V  P   G+    E +                     +E  
Sbjct: 1981 EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040

Query: 402  TETKDGSGLEEKVRAKLVPSQEETK-----LSVEESEAAGDGVDTKVAQGATEKSPEDKV 456
            T+  +G    E    +   ++EE +     +   E EA  +  D    +   E  PE + 
Sbjct: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100

Query: 457  QIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516
              A   E + ++ +  E  ETEG  + + E  +  E   ++  E++ ++  + E  G  +
Sbjct: 2101 VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAE--GEAQ 2158

Query: 517  LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL 576
               + ++      + +E  + +L   +A    GE   ESE  ++A E             
Sbjct: 2159 PESEGIEAQ----EAEEEAQPELEGVEAPEAEGEAQPESEG-IEAPE------------- 2200

Query: 577  EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYK 636
                   AE   Q  L      + +E      + +E  E       E   E+EG +   K
Sbjct: 2201 -------AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE----GEAQPESEGETQGEK 2249

Query: 637  KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIAS 696
            K   ++          + D +  + S + + +         S  G TP     S +  +S
Sbjct: 2250 KGSPQV---------SLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSS 2300

Query: 697  RKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDA--KKAKQEPEVNGGSGDAVPSGNE 754
             + +   +     ++  H++   R P+ +S     A  K  +  PE +    +  P G+ 
Sbjct: 2301 SRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSR 2360

Query: 755  VSENMEEEAENQAESRA 771
              E    E  +  E +A
Sbjct: 2361 TPEQGASEGYDLQEDQA 2377



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 56/259 (21%), Positives = 109/259 (42%), Gaps = 39/259 (15%)

Query: 117  EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 176
            E+E E+  +E    +N  +++ A   ++E+V     + EE K+  +    + E  + +++
Sbjct: 1273 EDEAERDSEEQRASSN--LEQLAENTVQEEV-----QLEETKEGTEGEGLQEEAVQLEET 1325

Query: 177  EMEKGGRED---MDISKSAE-EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232
            + E+G +E+   ++ +K  E E Q++ +  L+ + ET  E   G   EG    EV  G  
Sbjct: 1326 KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE---GLQEEGVQLEEVKEG-- 1380

Query: 233  EQEVPDAEEEKSVSGTDVQEECREKGGQEK---QGEVIVSIEEKPKEVSEEQPVVTLEKQ 289
                     E  + G  ++E  +E+G  E+    G+ +        + S+E   V  E+ 
Sbjct: 1381 --------PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEA 1432

Query: 290  GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 349
            G A          + +P    G E   +  +  +E   +  E+  G ++ P  E P   T
Sbjct: 1433 GRA--------SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484

Query: 350  ----EAAEASAVEAGSEVS 364
                E  +A   +  +E S
Sbjct: 1485 MMGQEHTQAQPTQGAAERS 1503



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/198 (22%), Positives = 79/198 (39%), Gaps = 22/198 (11%)

Query: 97   ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156
            E  ++E    G   EG+  E  + E+T+ E  ++      EE +E   E   +   + EE
Sbjct: 1299 EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEE 1358

Query: 157  AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGG 216
             ++T  + L +     E+  E  +GG +     ++ EE           L E     +G 
Sbjct: 1359 IEETGGEGLQEEGVQLEEVKEGPEGGLQ----GEALEE----------GLKEEGLPEEGS 1404

Query: 217  AAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKE 276
               +  +EA    GK  QE    +EE++   +   E C  +G +E          E P  
Sbjct: 1405 VHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP--------TEPPSH 1456

Query: 277  VSEEQPVVTLEKQGTAVE 294
            +SE  P  +  + G+ +E
Sbjct: 1457 LSETDPSASERQSGSQLE 1474



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 14/124 (11%)

Query: 399  ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV--------DTKVAQGATEK 450
            ER +E +  S   E++    V  QEE +L   +    G+G+        +TK  +G  E+
Sbjct: 1277 ERDSEEQRASSNLEQLAENTV--QEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEE 1334

Query: 451  SPE-DKVQIAANEETQEREEQMKEGEET--EGSEEDDKENDKTEEMPNDSVLENKSLQEN 507
              + ++ +    E  QE E Q++E EET  EG +E+  + ++ +E P +  L+ ++L+E 
Sbjct: 1335 GVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP-EGGLQGEALEEG 1393

Query: 508  EEEE 511
             +EE
Sbjct: 1394 LKEE 1397


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 124/567 (21%), Positives = 229/567 (40%), Gaps = 54/567 (9%)

Query: 115 VEEEEGEKTEDESLVENNDN---IDEEAREELREQ--VYDAMGEKEEAKKT-EDKSLAKP 168
           V +EE + T   + VE +D    ++  AR E R Q  + +A+  ++E   T  D SL+ P
Sbjct: 74  VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP 133

Query: 169 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 228
               + D+       E  +  + +E  QE+ ++     TET                 VT
Sbjct: 134 SRRMQNDT----AENETTEKEEKSESRQERYEIEE---TET-----------------VT 169

Query: 229 SGKPEQEVPDAEEEKSVSGT-DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287
               + +  DAEE K      + +EE + K G   + +V V +EEK  E  EE  V++L+
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229

Query: 288 KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEV 347
               + E   +  +      ++   E  E+      EA +A LE    + +  AE+  ++
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKKI 288

Query: 348 TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG 407
             E A   A E  +   E+  +EA    +       +    Q   E +   +R  E +  
Sbjct: 289 ADERARIEAEEKAA-AQERERREAEERERMREEEKRAAEERQRIKEEE---KRAAEERQR 344

Query: 408 SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQER 467
              EEK  A     +E  ++  EE  AA +    +  +    K  E K      E+    
Sbjct: 345 IKEEEKRAA-----EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399

Query: 468 EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 527
           +E   +GE+ E   E    N+K  +   +  L+   L++  EE+   ++   + L   K 
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQ---EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456

Query: 528 IFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETH 587
            FK++E K+ ++       K  E   E ++++   + F    +   +++    +    T 
Sbjct: 457 TFKKEEIKDEKIK------KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTF 510

Query: 588 YQLGLAYGYNSQYDEAVAQFS--KSIEVIENRMAVL-NEQVKEAEGSSAEYKKEIEELKE 644
            + G     +++  E   Q    K +E +  R     +E+ ++ +    E   E+EELK+
Sbjct: 511 SRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKK 570

Query: 645 LLPEIREKIEDAKESQRSGNVAELALK 671
              E R K+ + +E +R    A+  L+
Sbjct: 571 KREE-RRKVLEEEEQRRKQEEADRKLR 596



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 94/428 (21%), Positives = 173/428 (40%), Gaps = 77/428 (17%)

Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELR-EQVYDAMGEKEEAKKTEDKSL--------- 165
           +EEE E+  DE  + +++ ++EE +E    E+      E+E  K  +DK +         
Sbjct: 240 QEEEREQGSDE--ISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297

Query: 166 ----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG 221
               A  E ++ +  E E+   E+   ++  +  +E+     +      EE K  A    
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357

Query: 222 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEK---------QGEVIVS--- 269
             + E      E++   AEEE+      V+E+ R K  +EK         +GE +     
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAK---VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414

Query: 270 ---IEEKPKEVSEEQPVVTL---EKQGTAVEVEAESLD---PTVKPVDVGGD------EP 314
              + EK  +  + Q  V     E++GT V+ + E L    PT K  ++  +      EP
Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474

Query: 315 EEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVL 374
           +E+V        K+ +++  G     ++    +T +      ++       +PG  A V 
Sbjct: 475 KEEV--------KSFMDRKKGFTEVKSQNGEFMTHK------LKHTENTFSRPGGRASVD 520

Query: 375 PKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEA 434
            K+ A   P V       E    +E L   +  +  EE    KL   Q+E  L +EE + 
Sbjct: 521 TKE-AEGAPQV-------EAGKRLEELRRRRGETESEE--FEKLKQKQQEAALELEELKK 570

Query: 435 AGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMP 494
                  +  +   E+  + + Q  A+ + +E EE+ +  EE E    +  E  K ++MP
Sbjct: 571 -----KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE--KRQKMP 623

Query: 495 NDSVLENK 502
            D + ++K
Sbjct: 624 EDGLSDDK 631



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 70/309 (22%), Positives = 126/309 (40%), Gaps = 45/309 (14%)

Query: 386 VGDQTPIEPQTSIE------RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGV 439
           V DQ  +  Q S+         T T+     E     +L   +E  +  ++E+       
Sbjct: 62  VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121

Query: 440 DTKVAQGATEKSPEDKVQIAANEETQEREEQMK------EGEETEGSEEDDKENDKTEEM 493
           D  +   +            A  ET E+EE+ +      E EETE   +  ++ND  +  
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181

Query: 494 PNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSV 553
            N    E+K  +E EEE+     +  + ++    +   ++T E+Q       LK G++S 
Sbjct: 182 ENKK--EDKEKEEEEEEKPKRGSIGENQVE----VMVEEKTTESQEETVVMSLKNGQISS 235

Query: 554 E----SENYVQAVEEFQSCLNLQEQYLEAHD----RLLAETHYQLGLAYGYNSQYDEAVA 605
           E     E   Q  +E      ++E+  E  +    RL AE   ++       ++ D+ +A
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI------KAEQDKKIA 289

Query: 606 QFSKSIEV--------IENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED-- 655
                IE          E R A   E+++E E  +AE ++ I+E ++   E R++I++  
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349

Query: 656 ---AKESQR 661
              A+E QR
Sbjct: 350 KRAAEERQR 358



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 68/320 (21%), Positives = 124/320 (38%), Gaps = 32/320 (10%)

Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDL 524
           Q+REE   E E       DD E +   E    +  E +  Q+ EEE +G       + D 
Sbjct: 13  QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE-RLRQKQEEESLG------QVTDQ 65

Query: 525 AKIIFKRQ-ETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLL 583
            ++  +     +EA+       ++  + +   E   +  E  Q  L    +  +  D  +
Sbjct: 66  VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 125

Query: 584 AETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK-EIEEL 642
            +    L        Q D A  + ++  E  E+R      +++E E  +  Y+K +  + 
Sbjct: 126 TDASLSLP---SRRMQNDTAENETTEKEEKSESRQE--RYEIEETETVTKSYQKNDWRDA 180

Query: 643 KELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS-SVSMIASRKPTD 701
           +E   E +EK E+ +E  + G++ E  ++  + E +T         S     I+S +P  
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240

Query: 702 GASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEE 761
                    +ISH      K EEE   + +A++A+ E E             E      E
Sbjct: 241 EEEREQGSDEISH----HEKMEEEDKERAEAERARLEAE-------------ERERIKAE 283

Query: 762 EAENQAESRAAVEGTVEAGA 781
           + +  A+ RA +E   +A A
Sbjct: 284 QDKKIADERARIEAEEKAAA 303


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 102/427 (23%), Positives = 169/427 (39%), Gaps = 49/427 (11%)

Query: 111 EGVHVEE--EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168
           E V VEE  EE + TE+ +  E  +  +EE +EE         GE+EEA+  E+++ + P
Sbjct: 453 ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE-------EGGEEEEAEGGEEETKSPP 505

Query: 169 -ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEA-- 225
            E     + E +   +E+      A+ P++             EEAK  A  + P +A  
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEK-------------EEAKSPAEVKSPEKAKS 552

Query: 226 ---EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP 282
              E     PE + P+ EE KS +     E+ +    +E +        EK K   +E+ 
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 283 VVTLEKQGTAVE-----VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQE 337
               E +    E      E +S +    P       P EK  + E E  K+   +     
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP-EKAKSPEKEEAKS--PEKAKSP 669

Query: 338 VPPAEESPEVTTEAAEASA---VEAGSEVSE--KPGQEAPVLPKDGA-----VNGPSVVG 387
           V    +SPE      +A A    +A S V E  K  ++A    K+ A        P    
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729

Query: 388 DQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGA 447
            +TP + ++ ++   ++ + +   EK +   V S E    + EE+ +  D    K     
Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV 789

Query: 448 TE--KSPED-KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 504
            E  KSPE  K  +  + +  E+E   KE  ++   EE+  +  K +E P  +  E    
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA 849

Query: 505 QENEEEE 511
               EE+
Sbjct: 850 TPKTEEK 856



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 135/659 (20%), Positives = 237/659 (35%), Gaps = 116/659 (17%)

Query: 121  EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180
            EK+E E+++      + +  EE+ E+      E++EAK+ E K       ++E   E E 
Sbjct: 448  EKSEKETVIVEEQTEETQVTEEVTEE------EEKEAKEEEGK-------EEEGGEEEEA 494

Query: 181  GGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVP 237
             G E+   S  AEE   P+++        +   EEAK  A  + P + E    K   EV 
Sbjct: 495  EGGEEETKSPPAEEAASPEKEAK------SPVKEEAKSPAEAKSPEKEEA---KSPAEVK 545

Query: 238  DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 297
              E+ KS +  + +     K  ++++ +        P EV   +   +  K+      EA
Sbjct: 546  SPEKAKSPAKEEAKSPPEAKSPEKEEAK-------SPAEVKSPEKAKSPAKEEAKSPAEA 598

Query: 298  ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 357
            +S +    PV      P E     + EA           EV   E++   T E A++   
Sbjct: 599  KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA-------EVKSPEKAKSPTKEEAKSPEK 651

Query: 358  EAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAK 417
                E  E    E    P       P         E ++  +  +  K+ +   EK ++ 
Sbjct: 652  AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711

Query: 418  L---VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474
            +     S E+ K  V+E     +   + V + A  KSPE     A + E  +  +     
Sbjct: 712  VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA--KSPEK----AKSPEKAKTLDVKSPE 765

Query: 475  EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 534
             +T   EE     DK  E     V E     E +  E     L  D     K I K++E 
Sbjct: 766  AKTPAKEEARSPADKFPEKAKSPVKE-----EVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820

Query: 535  KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAY 594
            K                 V+ E   Q V+  +     +E+   A  +   +         
Sbjct: 821  KSP---------------VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK-------- 857

Query: 595  GYNSQYDEAVAQFSKSIEVIENRMAVLN---EQVKEAEGSSAEYKKEIEELKELLPEIRE 651
              +S+ +EA  + +   +V E +   +    E   EA+   AE KK++   ++  P   E
Sbjct: 858  --DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915

Query: 652  KIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTD 711
              EDAK  ++                              + +A ++P D  +       
Sbjct: 916  VKEDAKPKEK------------------------------TEVAKKEPDDAKAKE----P 941

Query: 712  ISHLVRKKRKPEEESPRKDDAKKAKQEPEVNG-GSGDAVPSGNEVSENMEEEAENQAES 769
                 +K+  PE++  +++ AKK +++P+       D      E S+   E+AE  + +
Sbjct: 942  SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 94/415 (22%), Positives = 172/415 (41%), Gaps = 33/415 (7%)

Query: 119 EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEM 178
           E E+ +  + V++ +     A+EE +        EKEEAK   +  +  PE  K    E 
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE--VKSPEKAKSPAKEE 591

Query: 179 EKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS---GKPEQE 235
            K   E     K+    +E+     +  +   EEAK  A  + P +A+  +    K  ++
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651

Query: 236 VPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE---EQPVVTLEKQGTA 292
               E+E++ S    +   + +    ++ +  V  E K  E ++   ++   + EK  + 
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711

Query: 293 VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 352
           V+ EA+S +    PV      PE+     + EA      +   +      +SPE  T A 
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771

Query: 353 EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE-----PQTSIERLTETKDG 407
           E    EA S   + P  E    P    V  P     ++P++     P+  I +  E K  
Sbjct: 772 E----EARSPADKFP--EKAKSPVKEEVKSPEKA--KSPLKEDAKAPEKEIPKKEEVK-- 821

Query: 408 SGLEEKVRAKLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQIAANEE 463
           S ++E+ + + V  +E  K + EE   A     +  D+K  +   +++P+ KV+    E+
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE----EK 877

Query: 464 TQEREEQMKEGE-ETEGSEEDDKENDKTEEMPNDSVLENK-SLQENEEEEIGNLE 516
            +   E+ KE + E +  E +DK+   T E    + +E K   +  E+ E+   E
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 92/409 (22%), Positives = 159/409 (38%), Gaps = 46/409 (11%)

Query: 122  KTEDESLVENNDNIDEEAR--------EELREQVYDAMGEKEEAKKTEDKSLAKPETDKE 173
            K E +S  E    + EEA+        E+ +    +     E+AK  E +    PE  K 
Sbjct: 609  KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668

Query: 174  QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG-KP 232
                  K   +     K+  +  EK    +    ++ E+AK     E  +  +  S  K 
Sbjct: 669  PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 233  EQEVPDAEE----EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288
            E + P+  +    E++ S    +   + K    K  E     +E+ +  +++ P    EK
Sbjct: 729  EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP----EK 784

Query: 289  QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP---PAEESP 345
              + V+ E +S +    P+      PE+++   E E    V E+   QEV    P +++ 
Sbjct: 785  AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEKPQEVKVKEPPKKAE 843

Query: 346  EVTTEAAEASAVEAGSEVSEKPGQEAPVLP----KDGAVNGPSVVGDQTPIE-------- 393
            E    A   +  +  S+  E P +EAP       K+ AV  P     +   E        
Sbjct: 844  EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903

Query: 394  --PQTSIERLTETKDGSGLEEKVR-AKLVPSQEETK---LSVEESEAAGDGVDTKVAQGA 447
              P+       E K+ +  +EK   AK  P   + K      E+ EAA +  DTK  +  
Sbjct: 904  PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA- 962

Query: 448  TEKSPEDKVQIAA----NEETQEREEQMKEGEETEGSEEDDKENDKTEE 492
              K PE+K +  A    +++T  +E    + E+ E S   D+++ K  E
Sbjct: 963  --KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 54/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE--DKSLAKPETDKE 173
            EE +    E+E   E       +  EE +        EK+++KK E   K   KP+ +++
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877

Query: 174  QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 233
            ++  +EK     ++  K   E ++KV  T +       E K  A P+   + EV   +P+
Sbjct: 878  KEPAVEKPKESKVEAKKEEAEDKKKVP-TPEKEAPAKVEVKEDAKPK--EKTEVAKKEPD 934

Query: 234  QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK-EVSEEQPVVTLEKQGTA 292
                DA+ ++     + +E   EK  ++ + E     EEKPK E   ++   TL K+ + 
Sbjct: 935  ----DAKAKEPSKPAEKKEAAPEK--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK 988

Query: 293  VEVE-AESLDPTVKPVDVGGDEPEEKVVTSENEAGK 327
             + E AE    T    D    +P EK    +   GK
Sbjct: 989  PKAEKAEKSSST----DQKDSKPPEKATEDKAAKGK 1020



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 94/427 (22%), Positives = 158/427 (37%), Gaps = 94/427 (22%)

Query: 403 ETKDG------SGLEEKVRAKLVPSQEETKLSVEE---------SEAAGDGVDTKVAQGA 447
           ET+D       S L E +RA+L     ++ L  EE         SEAA   V+T   + A
Sbjct: 258 ETRDALKCDVTSALRE-IRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAK--VNTDAMRSA 314

Query: 448 TEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPN-----DSVLENK 502
            E+  E + Q+ A     E  +  K+  E + SE +D+               D+ L N 
Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374

Query: 503 ----SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE-------- 550
               + Q  E +++ N+++A D+   A    K  E +E ++        L E        
Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAA--YRKLLEGEECRIGFGPIPFSLPEGLPKIPSV 432

Query: 551 ---VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQF 607
              + V+SE  ++ VE+ +    + E+  E                    +Q  E V + 
Sbjct: 433 STHIKVKSEEKIKVVEKSEKETVIVEEQTE-------------------ETQVTEEVTE- 472

Query: 608 SKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAE 667
                  E       E+ KE EG   E  +  EE +   P   E     KE+        
Sbjct: 473 -------EEEKEAKEEEGKEEEGGEEEEAEGGEE-ETKSPPAEEAASPEKEA-------- 516

Query: 668 LALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESP 727
              K+ + E + S         S     ++ P +  S     +        K  PE +SP
Sbjct: 517 ---KSPVKEEAKSP----AEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPPEAKSP 567

Query: 728 RKDDAK---------KAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 778
            K++AK         KAK   +    S     S  +    ++EEA++ AE+++ V+   +
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627

Query: 779 AGATVES 785
           + A V+S
Sbjct: 628 SPAEVKS 634


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 99/419 (23%), Positives = 180/419 (42%), Gaps = 50/419 (11%)

Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS 176
           +++ +K +    +E+  N D++A  +++        +KE  +K  D+  AK    KE++ 
Sbjct: 200 QKKNQKNKPGPNIESG-NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE- 257

Query: 177 EMEKGGREDMDISKSA---EEPQEKVDLTLDW--LTETSEEAKGGAAPEGPNEAEVTSGK 231
           E+E G ++     +S    EE   K  +T+D   +  + E+A+   A E  NE +    K
Sbjct: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK-K 316

Query: 232 PEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291
            +++    +EEK         +   K  QE   ++    EE+ ++  EE+  +   ++  
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK---EEEERQKREEEERIKRLEELE 373

Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ--LVGQEVPPAEESPEVTT 349
           A   E E L+           E  E+    E E  + + ++  L+ +    A    E T 
Sbjct: 374 AKRKEEERLE----------QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423

Query: 350 EAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG 409
           +  +A  VE  S+ S         LPK   +        +  I  Q   + ++E+ +   
Sbjct: 424 KLLQAQGVEVPSKDS---------LPKKRPIYEDK---KRKKIPQQLESKEVSESMELCA 471

Query: 410 LEEKVRAKLVPSQEETKLSVE-----ESEAAG-DGVDTKVAQGATEKSPEDKVQIAANEE 463
             E V  + VP +EET   VE     ++E AG D  +   +   TEK   +KV I   E 
Sbjct: 472 AVE-VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN 530

Query: 464 TQEREEQMKEGEETEGSEEDDK--------ENDKTEEMPNDSVLENKSLQENEEEEIGN 514
            +E EE+ +E EE E SEE+++        E D+ +E  +D     K+L +   +E+ +
Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS 589



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 60/261 (22%), Positives = 115/261 (44%), Gaps = 33/261 (12%)

Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175
           EEEE +K E+E  ++  + ++ + +EE R +      EK E KK         + +KE+ 
Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLE-----QEKRERKK---------QKEKERK 398

Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEG---PNEAEVTSGKP 232
             ++K G+    ++KS  E + + + TL  L     +A+G   P     P +  +   K 
Sbjct: 399 ERLKKEGKL---LTKSQREARARAEATLKLL-----QAQGVEVPSKDSLPKKRPIYEDKK 450

Query: 233 EQEVPDAEEEKSVSGT---DVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 289
            +++P   E K VS +       E  E+G  EK+ E    +E + +E +E+  +   E  
Sbjct: 451 RKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE-ETPPPVEPEEEEDTEDAGLDDWE-- 507

Query: 290 GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTT 349
             A + E E ++     ++V  +  EE+    E E  +   E+   +      E  E   
Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567

Query: 350 EAAEASAVEAGSEVSEKPGQE 370
           + ++    ++G  + +KP +E
Sbjct: 568 KVSDEK--DSGKTLDKKPSKE 586



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 118/572 (20%), Positives = 224/572 (39%), Gaps = 56/572 (9%)

Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE---TDK 172
           ++ +G+K +++   +  D  +++  +EL E   +A G K + +    K     E   T K
Sbjct: 38  QKSKGKKKKEK---KKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSK 94

Query: 173 EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNE-AEVTSGK 231
           ++  + +KG ++  D    +EE ++K   +        E   G    +  N+  +   GK
Sbjct: 95  DKKKKGQKGKKQSFD-DNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGK 153

Query: 232 PEQEVP--DAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQ 289
            ++     D  EE   +   ++E  R     E   E    ++ +  +   ++      K 
Sbjct: 154 AQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK-----NKP 208

Query: 290 GTAVEVEAESLDPTVKPVDVGGDEPEEKV-VTSENEAGKAVLEQLVGQEVPPAEESPEVT 348
           G  +E   E  D + K   V   + E+K     + +  KA L +L        +E  E+ 
Sbjct: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL--------KEKEELE 260

Query: 349 TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD-- 406
           T   + S  +      E+   ++ V    G +   S    +TP   +   E   + KD  
Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPA-SEEKAETPTAAEDDNEGDKKKKDKK 319

Query: 407 --GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET 464
                 EEK + K     + T  +++E+ A       K  +   ++  E++++     E 
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALA-----KLKEEEERQKREEEERIKRLEELEA 374

Query: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL------- 517
           + +EE+  E E+ E  ++  KE ++ E +  +  L  KS +E        L+L       
Sbjct: 375 KRKEEERLEQEKRERKKQ--KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432

Query: 518 --AWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQY 575
             + D L   + I++ ++ K+         L+  EVS ES     AVE  +  +  +E+ 
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKK-----IPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486

Query: 576 LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKS---IEVIENRMAVLNEQVKEAEGSS 632
               +    E     GL        DE   +   +   IEV EN      E+ +E E   
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546

Query: 633 AEYKKEIEELKELL--PEIREKIEDAKESQRS 662
           +E ++E E   E     E  EK+ D K+S ++
Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 118/616 (19%), Positives = 240/616 (38%), Gaps = 86/616 (13%)

Query: 190 KSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249
           K+  E   K D+ LD L    E A  GAA E   +      K E++  D +E+  +   +
Sbjct: 6   KNKSEDSTKDDIDLDALAAEIEGA--GAAKEQEPQKSKGKKKKEKKKQDFDEDDILK--E 61

Query: 250 VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDP------- 302
           ++E   E  G +   E +     KP E +EE+   + +K+    + + +S D        
Sbjct: 62  LEELSLEAQGIKADRETVAV---KPTENNEEE-FTSKDKKKKGQKGKKQSFDDNDSEELE 117

Query: 303 --------TVKP---VDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351
                   T KP   +  G D+ ++     +   GKA   Q   ++   +EE  + + + 
Sbjct: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA---QKSNKKWDGSEEDEDNSKKI 174

Query: 352 AEASAV----EAGSEVSE----KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTE 403
            E S +    E+G E  E    + GQ+     K G    P++       +    I+ + +
Sbjct: 175 KERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG----PNIESGNEDDDASFKIKTVAQ 230

Query: 404 TKDGSGLEEKVRAKLVPSQEETKL-SVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANE 462
            K     E+K R +    +E+ KL  ++E E        ++  G  ++S + + Q    E
Sbjct: 231 KK----AEKKERERKKRDEEKAKLRKLKEKE--------ELETGKKDQSKQKESQRKFEE 278

Query: 463 ETQEREEQMKEG--------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 514
           ET + +  +  G         ET  + EDD E DK ++       + K  +E +E+E   
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKK----KKKGEKEEKEKEKKK 334

Query: 515 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHLK-LGEVSVESENYVQAVEEFQSCLNLQE 573
                 +  + + + K +E +E Q    +  +K L E+  + +   +  +E +     +E
Sbjct: 335 GPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE 394

Query: 574 ----QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAE 629
               + L+   +LL ++  +         +  +A      S + +  +  +  ++ ++  
Sbjct: 395 KERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKI 454

Query: 630 GSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGS 689
               E  KE+ E  EL   +    +   E + +            VE      T   G  
Sbjct: 455 PQQLE-SKEVSESMELCAAVEVMEQGVPEKEET---------PPPVEPEEEEDTEDAGLD 504

Query: 690 SVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAV 749
               +AS + T+    +    ++     ++ + EEE    +++++ ++E   + GS    
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGS---- 560

Query: 750 PSGNEVSENMEEEAEN 765
             G+E  E + +E ++
Sbjct: 561 -EGDEEDEKVSDEKDS 575



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 1/82 (1%)

Query: 113 VHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDK 172
           VH+E +E  + E+E   E  ++ + E  EE   +   + G++E+ K +++K   K   DK
Sbjct: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK-TLDK 581

Query: 173 EQDSEMEKGGREDMDISKSAEE 194
           +   EM      D D  ++ EE
Sbjct: 582 KPSKEMSSDSEYDSDDDRTKEE 603



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 73/397 (18%), Positives = 157/397 (39%), Gaps = 16/397 (4%)

Query: 272 EKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG-KAVL 330
           +K K  SE+     ++    A E+E        +P    G + +EK     +E      L
Sbjct: 3   KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62

Query: 331 EQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQT 390
           E+L  +      +   V  +  E +  E  S+  +K GQ+      D   N    + D+ 
Sbjct: 63  EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDD--NDSEELEDKD 120

Query: 391 PIEPQTSIERLT------ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVA 444
               +T+  ++       +  D + L +K + K   S ++   S EE E     +  +  
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGS-EEDEDNSKKIKERSR 179

Query: 445 QGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSL 504
             ++ +S ++  +   + + Q++ ++ K G   E   EDD  + K + +      + +  
Sbjct: 180 INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE 239

Query: 505 QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 564
           ++  +EE   L    +  +L      + + KE+Q    +  +K  +V+V++   + A EE
Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVK-SKVTVDT-GVIPASEE 297

Query: 565 FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ 624
                   E   E  D+   +   + G       + ++       +++ ++  +A L E+
Sbjct: 298 KAETPTAAEDDNEG-DKKKKDKKKKKG--EKEEKEKEKKKGPSKATVKAMQEALAKLKEE 354

Query: 625 VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 661
            +  +    E  K +EEL+    E  E++E  K  ++
Sbjct: 355 EERQKREEEERIKRLEELEAKRKE-EERLEQEKRERK 390



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 101 MENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELR------EQVYDAMGEK 154
           ME GV         VE EE E TED  L +      +E  E++       E   +   E+
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535

Query: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDIS 189
           EE ++ E+   ++ E ++E +SE  +G  ED  +S
Sbjct: 536 EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 2/82 (2%)

Query: 117 EEEGEKTEDESL-VENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175
           +EE EK E   + +E  +N +EE  EE  E+  D   E+EE ++ E +     E D++  
Sbjct: 512 DEETEKVEGNKVHIEVKENPEEEEEEE-EEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570

Query: 176 SEMEKGGREDMDISKSAEEPQE 197
            E + G   D   SK      E
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSE 592


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 94/417 (22%), Positives = 175/417 (41%), Gaps = 53/417 (12%)

Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSL----- 165
           E V V++++  KTE +  V   +   +E    ++ +V +      + K  ++K++     
Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643

Query: 166 AKPETDKEQDSEMEK--GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN 223
            KPE  KE+  + +K    +ED    K  E+P+++         E  +E K     E   
Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKE---------EVKKEVKKEIKKEEKK 694

Query: 224 EAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPV 283
           E       P++EV      K V     +EE +E   +EK+ +    I++ PK+  +    
Sbjct: 695 E-------PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK--KEIKKLPKDAKKSSTP 745

Query: 284 VTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEE----KVVTSENEAGKAVLEQLVGQEVP 339
           ++  K+  A++ +    + +VK   V   +P+E    KV+  E +A +AV   +      
Sbjct: 746 LSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATT 805

Query: 340 PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI- 398
            A  +         A  +EA   +   P      L KD        V     I+PQ  + 
Sbjct: 806 AAVMAAAGIAAIGPAKELEAERSLMSSPED----LTKDFEELKAEEVDVTKDIKPQLELI 861

Query: 399 ---ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK 455
              E+L ET       E V A ++  Q+E +++   +E+  +G+ T   +G  E++PE+ 
Sbjct: 862 EDEEKLKET-------EPVEAYVI--QKEREVTKGPAESPDEGITTTEGEGECEQTPEEL 912

Query: 456 VQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
             +    E Q  ++  K  +E  G EE  +  D  E+   +   E +  +E+ EE +
Sbjct: 913 EPV----EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE---EAEEPEEDGEEHV 962



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 90/407 (22%), Positives = 175/407 (42%), Gaps = 43/407 (10%)

Query: 117  EEEGEKTEDESLVENNDNID-EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175
            ++E  K ED++ ++  +    EE ++E+++++      K+E KK   K + K    KE  
Sbjct: 657  KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI------KKEEKKEPKKEVKKETPPKEVK 710

Query: 176  SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP--EGPNEAEVTSGKPE 233
             E++K   E  ++ K  +EP++++        +  ++AK  + P  E    A +    P+
Sbjct: 711  KEVKK--EEKKEVKKEEKEPKKEIK-------KLPKDAKKSSTPLSEAKKPAALKPKVPK 761

Query: 234  QEVPDAEEEKSVSGTDVQEECREK--GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291
            +E  ++ ++ SV+    +E+ + K    + K  E + +        +       +   G 
Sbjct: 762  KE--ESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819

Query: 292  AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351
            A E+EAE       P D+  D  E K    E +  K +  QL   E    +E     TE 
Sbjct: 820  AKELEAER-SLMSSPEDLTKDFEELKA--EEVDVTKDIKPQLELIE----DEEKLKETEP 872

Query: 352  AEASAVEAGSEVSEKPGQ--EAPVLPKDGAVNGPSVVGDQTPIEPQ--TSIERLTETKDG 407
             EA  ++   EV++ P +  +  +   +G         +  P+E Q    IE+  +  +G
Sbjct: 873  VEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFED--EG 930

Query: 408  SGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---EDKVQIAANEET 464
            +G EE           E K   EE+E   +  +  V   A++ SP   E+  +  A+   
Sbjct: 931  AGFEESSET----GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986

Query: 465  QEREEQMKEGEETEGSEEDDK-ENDKTEEMPNDSVLENKSLQENEEE 510
            +E+ E +  G++    + D+  E  + E+   ++  E+K+    EEE
Sbjct: 987  REKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 102/424 (24%), Positives = 172/424 (40%), Gaps = 59/424 (13%)

Query: 142 ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR-EDMDISKSAEEPQEKVD 200
           +L+++       K  AK    KS+ K    KE+  E+ K    E     +S E+   K D
Sbjct: 534 KLKQRADSRESLKPAAKPLPSKSVRKES--KEETPEVTKVNHVEKPPKVESKEKVMVKKD 591

Query: 201 LTLDWLTETSEEAKGGAAPEGPN--EAEVTSGKPEQEVPDAEEEKSVS-----GTDVQEE 253
             +   T+ S   K   + E P+  +AEV   +     P A +EK+V        + ++E
Sbjct: 592 KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKE 651

Query: 254 CREKGGQE---KQGEVIVSIEEKPK--EVSEE-----------QPVVTLEKQGTAVEVEA 297
            +EK  +E   K+ +  +  EEKPK  EV +E           +P   ++K+    EV+ 
Sbjct: 652 EKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKK 711

Query: 298 ESLDPTVKPVDVGGDEPEEKVVTSENEAGK-------AVLEQLVGQEVPPAEESPEVTTE 350
           E      K V     EP++++     +A K       A     +  +VP  EES +  + 
Sbjct: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV 771

Query: 351 AAEASAVEAGSEVSEKPGQEAPVLPK---DGAVN-------GPSVVGDQTPIEPQTSIER 400
           AA     +   +V +K G+ A  +      GA         G + +G    +E + S+  
Sbjct: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831

Query: 401 LTE--TKDGSGLEE---------KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 449
             E  TKD   L+          K + +L+  +E+ K   E  EA     + +V +G  E
Sbjct: 832 SPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLK-ETEPVEAYVIQKEREVTKGPAE 890

Query: 450 KSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK---TEEMPNDSVLENKSLQE 506
            SP++ +     E   E+  +  E  E +G ++ +K  D+    EE       E K+  E
Sbjct: 891 -SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949

Query: 507 NEEE 510
             EE
Sbjct: 950 EAEE 953



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 98/430 (22%), Positives = 160/430 (37%), Gaps = 85/430 (19%)

Query: 111  EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170
            EG+   E EGE    E   E  + ++++  +++ E+  D     EE+ +T D    K ET
Sbjct: 894  EGITTTEGEGEC---EQTPEELEPVEKQGVDDI-EKFEDEGAGFEESSETGDYE-EKAET 948

Query: 171  DKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLD-WLTETSEEAKGG--AAPEGPNE 224
              E+  E E+ G E + +S S   P   +E      D ++ E  E    G   A E  +E
Sbjct: 949  --EEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDE 1006

Query: 225  AEVTSGKPEQEVPDAEEEKSVSGTDVQE-----------------ECREKGGQEKQ-GEV 266
            A +  G+ EQ   +A+EE        +E                 +  E GG E+Q G +
Sbjct: 1007 A-IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFL 1065

Query: 267  IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326
                ++   +    +P  ++  +      E+E+   T    +   D+PEE   TS    G
Sbjct: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEA---TASDEENREDQPEEFTATS----G 1118

Query: 327  KAVLEQLVGQEVPPAEE--------SPEVTTEAAEASAVE-------AGSEVSEKPGQEA 371
                   +  E  P +E        S E   E  E+ + E         S  S++  + A
Sbjct: 1119 YTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178

Query: 372  PVLPKDG--------AVNGPSVVGDQTPIEPQTSIER------------LTETKDGSGLE 411
             V P +G        A +G       + I P +S+E              +E K  + L+
Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238

Query: 412  ----------EKVRAKLVPSQEETKLSVEESEAAGD-GVDTKVAQGATEKSPEDKVQIAA 460
                      EKV     PS   +  S  E    G+  V+  +     + S E +V   +
Sbjct: 1239 IKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVS 1298

Query: 461  NEETQEREEQ 470
             E TQE  E+
Sbjct: 1299 PEVTQEVVEE 1308



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 35/110 (31%), Positives = 52/110 (47%), Gaps = 9/110 (8%)

Query: 411 EEKVRAKL-VPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREE 469
           +EKV  K   P + ETK SV E E       + V     EK   D    AA E+T ++E 
Sbjct: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642

Query: 470 QMKEGEETEGSEEDDKE----NDKT----EEMPNDSVLENKSLQENEEEE 511
           ++K  ++ E  E+  KE     DKT    EE P    ++ +  +E ++EE
Sbjct: 643 KVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEE 692


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 121/557 (21%), Positives = 225/557 (40%), Gaps = 49/557 (8%)

Query: 118 EEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETD-KEQDS 176
           +E E  E E  +   +       E LREQ    M E+EE    ++K L + E + +EQ+ 
Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMWRQEKRLREQEKELREQEK 335

Query: 177 EMEKGGREDMDISKSAEEPQEKVDLTLDWLTE---TSEEAKGGAAPEGPNEAEVTSGKPE 233
           E+    RE  ++ +  E+ QE+ +    W  E     +E K     E   E E    + E
Sbjct: 336 EL----REQKELREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389

Query: 234 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293
           Q++ D EE       +  E  REK  + ++ E +    EK +E  + Q            
Sbjct: 390 QKMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKMREEKKMQ------------ 433

Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353
           E E ++ D   K  +       EK +  E E  +   E++  QE    E+  +   +   
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493

Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEE 412
               E   E  +   QE  +  ++  +     +  Q   +     E++ E +D     EE
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE--KKMWRQEKMREQEDQMWEQEE 551

Query: 413 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 472
           K+R      QE+     EE          K  Q   +K+ + + ++   E  +ERE++M+
Sbjct: 552 KMR-----DQEQKMWDQEERM-------EKKTQEQEKKTWDQEEKMREEERMREREKKMR 599

Query: 473 EGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFK 530
           E EE   E  E+  ++ +K +E       + + +QE EE+     E  W+     + +++
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ---EEKMWE 656

Query: 531 RQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQL 590
           +Q   E Q      H K+ E     E   +  E+ +     QEQ  +  D+        +
Sbjct: 657 QQRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715

Query: 591 GLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIR 650
                   + +E + +  + ++  E +M    E++ E E    E ++++ E ++ LPE +
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE-QQRLPEQK 774

Query: 651 EKIEDAKESQRSGNVAE 667
           EK+ + ++ Q    + E
Sbjct: 775 EKLWEHEKMQEQEKIWE 791



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 79/408 (19%), Positives = 168/408 (41%), Gaps = 73/408 (17%)

Query: 116 EEEEGEKTEDESLVENNDNIDEEAREELRE--QVYDAMGEKEEAKKTEDKSLAKPETDKE 173
           E+EE  + +++ + +  + ++++ +E+ ++     + M E+E  ++ E K   + E  +E
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607

Query: 174 QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPE 233
           Q+ +M++   +  +  +   E +EK+           +E K     E   E E    + +
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQ---------EQEEKMWEQEEKMWEQEEKMWE-Q 657

Query: 234 QEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293
           Q +P+ ++EK      +QE+ + +  +EK  E     +EK ++ ++EQ   T +++    
Sbjct: 658 QRLPE-QKEKLWEHEKMQEQEKMQEQEEKIWE-----QEKMEKKTQEQEKKTWDQEKMR- 710

Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353
             E ES+               EK +  E E  +   E++  QE    E+  E+  +   
Sbjct: 711 --EEESM------------REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE-- 754

Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413
               E   E  EK  ++                            +RL E K+     EK
Sbjct: 755 ----EKMWEQEEKMWEQ----------------------------QRLPEQKEKLWEHEK 782

Query: 414 VRAKLVPSQEETKLSVEESEAAGD-----GVDTKVAQGATEKSPEDKVQIAANEETQERE 468
           ++ +    ++E K+  +E +  G      G + K+ +G  EK    + ++   EE    +
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM-RGQEEKMWGQEEKMWGQEEKMWGQ 841

Query: 469 EQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516
           E+   G+E +  E+   + +K  E       + + ++E EE+  G  E
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 80/366 (21%), Positives = 140/366 (38%), Gaps = 64/366 (17%)

Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170
           E   + E E +  E+E ++   +   +E  E+++EQ      ++E+ ++ E+K   + E 
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646

Query: 171 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 230
             EQ+ +M +  R          E +EK+     W  E  +E +                
Sbjct: 647 MWEQEEKMWEQQR--------LPEQKEKL-----WEHEKMQEQE---------------K 678

Query: 231 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQG 290
             EQE    E+EK    T  QE+ ++   QEK  E   S+ E+ K++ EE+ +  + +Q 
Sbjct: 679 MQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREE-ESMREREKKMREEEEM--MREQE 733

Query: 291 TAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE 350
             ++ + E +            E EE++   E +  +   +    Q +P   E  E   E
Sbjct: 734 EKMQEQEEKM-----------QEQEEEMWEQEEKMWEQEEKMWEQQRLP---EQKEKLWE 779

Query: 351 AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 410
             +    E   E  EK   +              + G +  +  Q    R  E K   G 
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQE-----------EKMRGQEEKMRGQEEKMRGQEEKMW-GQ 827

Query: 411 EEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQ 470
           EEK+       QEE     EE     +    +  QG  EK  E + ++   EE    +E+
Sbjct: 828 EEKMW-----GQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882

Query: 471 MKEGEE 476
              G+E
Sbjct: 883 KMRGQE 888



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 66/312 (21%), Positives = 129/312 (41%), Gaps = 52/312 (16%)

Query: 398 IERLTETKDGSGLE--------EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATE 449
           IE LT+ +D   LE        E+++ K    QE  KL + ESE +   ++ K  +   E
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQE--KLPLAESEKSEIQLNVKELKRKLE 256

Query: 450 KSPEDKVQIAAN---EETQEREEQMKEGE------------------ETEGS--EEDDK- 485
           ++     Q+  N   EE   +EE+++E E                  E EG   E+++K 
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316

Query: 486 --------ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEA 537
                   E +K        + E K L+E EE+     E  W+  +  +   ++   +E 
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376

Query: 538 QLYAAQAHLKLGEVSVESE-----NYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ--- 589
           +L+  +  ++  E  +  +        + + E +  +  QE+  E  +++  E   Q   
Sbjct: 377 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE 436

Query: 590 -LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPE 648
                     Q +E + +  K +   E  M    E++++ E +  E ++E E  ++ LPE
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE-QEEKEWQQQRLPE 495

Query: 649 IREKIEDAKESQ 660
            +EK+ + ++ Q
Sbjct: 496 QKEKLWEQEKMQ 507


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 142/656 (21%), Positives = 269/656 (41%), Gaps = 99/656 (15%)

Query: 73   LGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTE--DESLVE 130
            L ++  ET+ E G     + K+  +L   +  +L   +E   +EEE GEK E     L +
Sbjct: 557  LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616

Query: 131  NNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKG---GREDMD 187
               +  +  + E+ ++  + +  +EE K+ + +  ++    + +D E+EK     R + D
Sbjct: 617  ARASAGDTRQVEVLKK--ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEAD 674

Query: 188  ISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSG 247
              +  EE   ++  TL  L +  EEA         ++A++ +   E E     + ++   
Sbjct: 675  RGRELEEQNLQLQKTLQQLRQDCEEA---------SKAKMVA---EAEATVLGQRRAAVE 722

Query: 248  TDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPV 307
            T ++E   E     ++   I+ +E++ KE         L   G AVE     L   ++ +
Sbjct: 723  TTLRETQEENDEFRRR---ILGLEQQLKETR------GLVDGGEAVEAR---LRDKLQRL 770

Query: 308  DVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSE----- 362
            +    + EE +  S+ E G           +  A+ + E   E A+      G E     
Sbjct: 771  EAEKQQLEEALNASQEEEG----------SLAAAKRALEARLEEAQRGLARLGQEQQTLN 820

Query: 363  -VSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTETKDGS---------GLE 411
               E+ G++  VL +  A +     + D+T       +E++ E    +           +
Sbjct: 821  RALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYK 880

Query: 412  EKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEET----QER 467
            EK R ++  +Q + K    E+E    G+     Q   ++  +      A  +T    +E 
Sbjct: 881  EKARREVADAQRQAKDWASEAEKTSGGLSR--LQDEIQRLRQALQASQAERDTARLDKEL 938

Query: 468  EEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENK--SLQENEEEEIGNLELAWDMLDLA 525
              Q  +G E E   +   ++D+  ++     LE K   L+   +EE   +EL  D ++  
Sbjct: 939  LAQRLQGLEQEAENKKRSQDDRARQLKG---LEEKVSRLETELDEEKNTVELLTDRVNRG 995

Query: 526  KIIFKRQETKEAQLYAAQAHLKLGEVSVESEN-----YVQAVEEFQ----SCLNLQEQYL 576
            +    +  T+  Q  +A+  L+  ++S+E +N      + + E FQ    S   L+ Q  
Sbjct: 996  RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ 1055

Query: 577  EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIE-----------VIENRMAVLNEQV 625
               +RL AE   +  L    N + +  V + S  IE            +  R+  L  QV
Sbjct: 1056 LLQERLQAEEREKTVL-QSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114

Query: 626  KEAE-------GSSAEYKKEIEELKELLPEIREKIED-AKESQR--SGNVAELALK 671
             EAE       G   + ++E+EE  E+  +++ +I+   K+S R  S + AE ALK
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALK 1170



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 17/302 (5%)

Query: 383 PSVVGDQTPIEPQTSIERLTET-----KDGSGLEE-----KVRAKLVPSQEETKLSVEES 432
           P ++ DQ    P  S++ +  T     ++GS   E     KV   L   Q    +S   +
Sbjct: 296 PDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355

Query: 433 EA-AGDGVDTKVAQGATEKSPEDKVQIAANEETQER-EEQMKEGEETEGSEEDDKENDKT 490
           +A AG G  T+  +    K  E+  +    E +Q   E Q++E  E     ++  E  K 
Sbjct: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415

Query: 491 EEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 550
           E   ++  L+N     ++ E++ +  L   +++L   +   Q  + A+    +  L+  E
Sbjct: 416 EAQQSNKELQNMKRLLDQGEDLRH-GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474

Query: 551 VSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGY-NSQYDEAVAQFSK 609
           +  E     Q VEE    L L+E+ L A    L E          +   QY     Q  +
Sbjct: 475 LLEEVLEGKQRVEEQ---LRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531

Query: 610 SIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELA 669
           S++      AVL  + ++        ++E+EE  E     +   +  KE  R+     L 
Sbjct: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591

Query: 670 LK 671
           L+
Sbjct: 592 LR 593


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 106/493 (21%), Positives = 197/493 (39%), Gaps = 66/493 (13%)

Query: 116  EEEEGEKT---EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK----- 167
            EEEEG+     ++     NN N D    +E  +   + +  K+   K   + L+K     
Sbjct: 1204 EEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNK 1263

Query: 168  -------------PETDKEQDSEMEKGGREDMDISKSAEEP---QEKVDLTLDWLTETSE 211
                         PET  E D ++    +++    K++  P   +E+V  T + L    E
Sbjct: 1264 ERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEE 1323

Query: 212  EAKGGA-APEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSI 270
              +    AP  PN +     KPE ++   EEE+     + +EE  E+G +E+ G  +   
Sbjct: 1324 NRREETCAPVSPNTSP--GEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKD 1381

Query: 271  EEKPKEVSEEQPVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEKVVTSE--- 322
             +  K   +E+P ++ EK+ +A      E E E  +P+        DE +  + ++E   
Sbjct: 1382 PDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEK 1441

Query: 323  ----NEAGKAVLEQ---LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375
                 E+ K VLE     +   V P   +PEV  +          SE  E  G +   +P
Sbjct: 1442 EELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAG-DPEAVP 1500

Query: 376  KDGAVNGPSVVGDQTPIEPQTSIERL-TETKDGSGLEEKVRAKLVPS-QEETKLSVEESE 433
            +      P   G+Q   + Q + + + TE K+G+    ++ ++ V + Q  T+ S E+ +
Sbjct: 1501 ESDEEPPP---GEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDD 1557

Query: 434  AAGDGVDTKVAQGATEK--SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTE 491
               D  +T+ A  + +     +   QIA    T +  +Q               ++ ++ 
Sbjct: 1558 TFQDCAETQEACRSLQNYTRADQSPQIAT---TLDDCQQSDHSSPVSSVHSHPGQSVRSV 1614

Query: 492  EMPNDSVLENKSLQENEEE------EIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAH 545
              P+   LEN   Q + ++       + N+E +  M+D+  +      +  +Q       
Sbjct: 1615 NSPSVPALENSYAQISPDQSAISVPSLQNMETS-PMMDVPSV------SDHSQQVVDSGF 1667

Query: 546  LKLGEVSVESENY 558
              LG +   +ENY
Sbjct: 1668 SDLGSIESTTENY 1680



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 104/488 (21%), Positives = 192/488 (39%), Gaps = 88/488 (18%)

Query: 157  AKKTEDKSLAKPETDK--EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
            A  +E++  A+ E ++  EQ S  EK  +E +    ++ +   KV     +L        
Sbjct: 995  AAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPV 1054

Query: 215  GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274
             G   E     E++    E+E  + E+E+     + +EE  E+  +E++ E   +I+  P
Sbjct: 1055 TG---ERGQLLELSKESSEEE-EEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110

Query: 275  KEVSEEQ--------PVVTLEKQGTA-----VEVEAESLDPTVKPVDVGGDEPEEK---- 317
              +++ Q        P V  +K+G         V  E++  T + ++   D  +E+    
Sbjct: 1111 PRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMP 1170

Query: 318  ------VVTSENEAGKAVLEQLV----GQEVPPAEE-----------SPEVTTEAAEASA 356
                   +  E +  K VL +      G++    EE            P       ++S 
Sbjct: 1171 QLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSN 1230

Query: 357  VEAGSEVSEKPGQEAPVLPKDGAVNGPS----------------VVGDQTPIEP--QTSI 398
            ++ GS+ + +P +   V PK G   G S                    +TP+EP  Q ++
Sbjct: 1231 LKEGSKDNPEPLKCKQVWPK-GTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTV 1289

Query: 399  ERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQI 458
            E   ET +G      +R +    +    L  +E     +         +  + PED + I
Sbjct: 1290 EEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDL-I 1348

Query: 459  AANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 518
               EE +E EE+ +E EE EG EE+   N   E+ P     +    QE EE EI      
Sbjct: 1349 KPEEEEEEEEEEEEEEEEEEGEEEEGGGN--VEKDP-----DGAKSQEKEEPEIST---- 1397

Query: 519  WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAV---------EEFQSCL 569
             +  D A++    +E +E +     +H +  +   E ++++++          E F+  L
Sbjct: 1398 -EKEDSARLDDHEEEEEEDE---EPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVL 1453

Query: 570  NLQEQYLE 577
              QE +L+
Sbjct: 1454 ENQETFLD 1461



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 98/428 (22%), Positives = 171/428 (39%), Gaps = 74/428 (17%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET----D 171
            EEEE E+ E+E   E  +  DEE  EE  E+      E+EE  ++    L KP++     
Sbjct: 1070 EEEEEEEDEEEEEEEEEEEEDEEEEEEEEEE------EEEENIQSSPPRLTKPQSVAIKR 1123

Query: 172  KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGK 231
            K      +K GR+   I+ S         +T + ++ET+E           NE    S +
Sbjct: 1124 KRPFVLKKKRGRKRRRINSS---------VTTETISETTEVL---------NEPFDNSDE 1165

Query: 232  PEQEVPDAEEEKSVSGTDVQEECRE----KGGQEKQGEVIVSIEEKPKE---VSEEQPVV 284
             E+ +P  E    +   +V+E+ R+    K  Q + G+   + EE+ K+        P  
Sbjct: 1166 -ERPMPQLEPTCEI---EVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCR 1221

Query: 285  TLEKQGTAVEVEAESLDPTVKPVDVGGDEPE-EKVVTSENEAGKAVLEQLVGQEVPPAEE 343
                  ++   E    +P  +P+      P+  K   S+    K   E+  G ++     
Sbjct: 1222 NNMNDDSSNLKEGSKDNP--EPLKCKQVWPKGTKRGLSKWRQNK---ERKTGFKL-NLYT 1275

Query: 344  SPEVTTEAAEASAVEAGSEVSEKPGQEAPV-LPKDGAVNGPSVVGDQTPIEPQTSIERLT 402
             PE   E  E   VE   E SE     +P+ + ++    G +++  +     +T      
Sbjct: 1276 PPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSP 1335

Query: 403  ETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---------- 452
             T  G   E+ +   + P +EE +   EE E   +  + +   G  EK P          
Sbjct: 1336 NTSPGEKPEDDL---IKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEE 1392

Query: 453  -------EDKVQIAANEETQEREEQMKEGEETEGSEEDDKEND----KTEEMPNDSVLEN 501
                   ED  ++  +EE +E +E+    E+ +  +EDD   +    + EE+P +S    
Sbjct: 1393 PEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESF--- 1449

Query: 502  KSLQENEE 509
            K + EN+E
Sbjct: 1450 KEVLENQE 1457



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 15/60 (25%), Positives = 31/60 (51%)

Query: 715  LVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774
            L++ + + EEE   +++ ++ + E E  GG+ +  P G +  E  E E   + E  A ++
Sbjct: 1347 LIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLD 1406


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 116/561 (20%), Positives = 233/561 (41%), Gaps = 69/561 (12%)

Query: 142  ELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDS----------EMEKGGREDMDISKS 191
            ++  Q  + M ++EE  K  +K LA      E ++          ++++  + + ++   
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 192  AEEPQEKVDLTLDWLTETSE--EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD 249
            AEE + ++      L E     EA+     E     +    K +Q + + EE+      +
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ-----LE 953

Query: 250  VQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 309
             +E  R+K   EK     V+ E K K++ EEQ  + LE Q   +  E + L+  +     
Sbjct: 954  EEESARQKLQLEK-----VTTEAKLKKLEEEQ--IILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 310  GGDEPEEKV-----VTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVS 364
               E EEK      + +++EA    LE+ + +E    +E  E T    E  + +   +++
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL-EKTRRKLEGDSTDLSDQIA 1065

Query: 365  EKPGQEAPV----LPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDG-SGLEEKV---RA 416
            E   Q A +      K+  +       ++   +   +++++ E +   S L+E +   RA
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125

Query: 417  KLVPSQEETKLSVEESEAAG----DGVDTKVAQGATEKSPEDKVQI---AANEETQEREE 469
                ++++ +   EE EA      D +D+  AQ       E +V I      EE +  E 
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185

Query: 470  QMKEGEE--TEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 527
            Q++E  +  ++  EE  ++ ++T+ +   ++ + K   ENE  E+ N E+   +      
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELAN-EVKVLLQGKGDS 1243

Query: 528  IFKRQETKEAQLYAAQAHLKLGE------------VSVESENYVQAVEEFQSCLNLQEQY 575
              KR++  EAQL   Q     GE            + VE +N    + +  S  +   + 
Sbjct: 1244 EHKRKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302

Query: 576  LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEY 635
              A +  L +T   L        + +      S  ++ +E+      EQ++E E +    
Sbjct: 1303 FSALESQLQDTQELL-------QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355

Query: 636  KKEIEELKELLPEIREKIEDA 656
            +K+I  L   + ++++K+ED+
Sbjct: 1356 EKQIATLHAQVADMKKKMEDS 1376



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 124/620 (20%), Positives = 241/620 (38%), Gaps = 128/620 (20%)

Query: 137  EEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQ 196
            E+ +   REQ    + E+EEAK   +K +A   T   Q ++M+K   + +   ++AEE +
Sbjct: 1335 EDEKNSFREQ----LEEEEEAKHNLEKQIA---TLHAQVADMKKKMEDSVGCLETAEEVK 1387

Query: 197  EKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDA----------------- 239
             K+   L+ L++  EE          ++ E T  + +QE+ D                  
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAY-----DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442

Query: 240  --------EEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGT 291
                     EEK++S    +E  R +    ++    +S+    +E  E++    LE+   
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK--AELERLNK 1500

Query: 292  AVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEA 351
                E E L  +    DVG           E E  K  LEQ V +E+    E  E   +A
Sbjct: 1501 QFRTEMEDLMSSKD--DVGKS-------VHELEKSKRALEQQV-EEMKTQLEELEDELQA 1550

Query: 352  AEASAVEAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGL 410
             E + +     +     Q E  +  +D          +Q+  + +  + ++ E +     
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDLQGRD----------EQSEEKKKQLVRQVREMEAELED 1600

Query: 411  EEKVRAKLVPSQEETKLSVEESEAAGDGVDT----------------KVAQGATEKSPED 454
            E K R+  V ++++ ++ +++ EA  D  +                 K      + +   
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660

Query: 455  KVQIAANEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----V 498
            + +I A  +  E++ +  E E  +  EE             + ++  +E+ N S      
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 499  LENK--------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE 550
            LE K         L+E  EEE GN EL  D L  A +   +  T    L   ++H +   
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT---DLNLERSHAQ--- 1774

Query: 551  VSVESENYVQAVEEFQSCLNLQEQYLE------------AHDRLLAETHYQLGLAYGYNS 598
               ++EN  Q +E     L ++ Q +E            A +  +A+   QL      N 
Sbjct: 1775 ---KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD-----NE 1826

Query: 599  QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 658
              +   A   K +   E ++  +  QV +   ++ +YK + ++    L +++ ++E+A+E
Sbjct: 1827 TKERQAA--CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884

Query: 659  SQRSGNVAELALKATLVESS 678
              +  N +   L+  L +++
Sbjct: 1885 EAQRANASRRKLQRELEDAT 1904



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 57/283 (20%), Positives = 112/283 (39%), Gaps = 28/283 (9%)

Query: 519  WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQS-----CLNLQE 573
            W +    K + +    +E  +   +  +K+ E  + +EN +  +E  QS      L LQE
Sbjct: 828  WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887

Query: 574  QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633
            Q L+A   L AE             + +E        +E  E R   L  + K+ + +  
Sbjct: 888  Q-LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 634  EYKKEIEE---------LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP 684
            E ++++EE         L+++  E + K  + ++        +LA +  L+E   + FT 
Sbjct: 947  ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 685  GGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGG 744
                      +  K  +       +TD+   +R++ K  +E       +K +++ E    
Sbjct: 1007 NLTEEEEKSKSLAKLKN--KHEAMITDLEERLRREEKQRQE------LEKTRRKLE---- 1054

Query: 745  SGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTA 787
             GD+    ++++E   + AE + +     E    A A VE  A
Sbjct: 1055 -GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 87/387 (22%), Positives = 166/387 (42%), Gaps = 34/387 (8%)

Query: 114 HVEEEEG-----EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168
           H E+E+G     EK + E    + + I+++ + E +    +    K  A+K+E+K+  K 
Sbjct: 164 HKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKT-AEKSEEKT--KK 220

Query: 169 ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPN---EA 225
           E    +  ++++   +  ++ K+  +P+EK D     +++  ++ +        +     
Sbjct: 221 EVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHG 280

Query: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285
           ++  G+     P    E++   T       EK G++K+ E  V+ E K KE   ++ +  
Sbjct: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE---KEDIKK 337

Query: 286 LEKQGTAVEVE-------AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEV 338
             ++ TA++VE       +E+   TVK       + +EK   S+     A +EQ  G++ 
Sbjct: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ 397

Query: 339 PPAEESPEVTTEAAEASAVEAGSEV---SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 395
              E+  E      +  +V +  +V   +E+  +E   +    AV G         +E +
Sbjct: 398 EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE 457

Query: 396 TSIERLTET----KDGS---GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTK--VAQG 446
              E+  +T    KD     G EEKV A L   + ETK   E+   AG  V  K    QG
Sbjct: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD-EKMSKAGKEVKPKPPQLQG 516

Query: 447 ATEKSPEDKVQIAANEETQEREEQMKE 473
             E+ PE +++  A     E+ +  K+
Sbjct: 517 KKEEKPEPQIKKEAKPAISEKVQIHKQ 543



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 61/272 (22%), Positives = 118/272 (43%), Gaps = 34/272 (12%)

Query: 122 KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPE------TDKEQD 175
           K   ++  + ++  ++  + +   +V    G+K+E K+   +    P+      +DK+  
Sbjct: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423

Query: 176 SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 235
           ++ E+   E   +S     P +K + T   + +   + K G       + E   GK E++
Sbjct: 424 AKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK-EEK 482

Query: 236 VPDAEEEKSVSGTDVQEECREKGGQE---KQGEVIVSIEEKPK-EVSEEQPVVTLEKQGT 291
           VP + +EK       ++E   K G+E   K  ++    EEKP+ ++ +E      EK   
Sbjct: 483 VPASLKEKEPE--TKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK--- 537

Query: 292 AVEVEAESLDPTVKPVDVGGDEPEEKV------VTSENEAGKAVLEQLVGQEVPP----- 340
            V++  + +    K V  G  +PEEKV      VT E  A     ++   +E  P     
Sbjct: 538 -VQIHKQDIVKPEKTVSHG--KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKT 594

Query: 341 --AEESPEVTTEAAEASAVEAGSEVSEKPGQE 370
              + +P+ T+E  E+   +  +E+SEK  +E
Sbjct: 595 DKPKPTPKGTSEVTESG--KKKTEISEKESKE 624



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 73/363 (20%), Positives = 136/363 (37%), Gaps = 39/363 (10%)

Query: 431 ESEAAGDGVDTKVAQGATEKSPEDKVQIAANE-ETQEREEQMKEGEETEGSEEDDKENDK 489
           E E   DG D    +G  ++ P  K +I  ++ E QE+ E+  + + T   +E  KE  +
Sbjct: 117 EDEEDDDG-DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175

Query: 490 TEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA------Q 543
            +E P       + +++ E+ E   L         AK   K +E  + ++         Q
Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKK---AKTAEKSEEKTKKEVKGGKQEKVKQ 232

Query: 544 AHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLE-AHDRLLAETHYQLGLAYGYNSQYDE 602
              K+ EV        +  ++ ++ ++  EQ  + A  R + +      L  G +     
Sbjct: 233 TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPP 292

Query: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI-EELKELLPEIREKIEDAKESQR 661
            +     S      R    +  ++E EG   + +K++  E K+     +EK +  K+S++
Sbjct: 293 PLPTEQAS------RPTPASPALEEKEGEKKKAEKKVTSETKK-----KEKEDIKKKSEK 341

Query: 662 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721
                E A+     E   +  T  G     +  A++K      S           +K  +
Sbjct: 342 -----ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK--------TKKPAE 388

Query: 722 PEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAE--NQAESRAAVEGTVEA 779
            E+   +K + K+   EP  +     +VPS  +V    E   E       + AV G  E 
Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448

Query: 780 GAT 782
             T
Sbjct: 449 KTT 451


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 119/602 (19%), Positives = 230/602 (38%), Gaps = 109/602 (18%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD 175
            +EEE E+ ED    E    +DEE  E + +      G   + K  +DK       +++++
Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKK------EEKEE 4836

Query: 176  SEMEKGGREDMDISKSAEE---PQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232
            +E + GG+ +  I++  +E    + +VD                  P   N+ +V    P
Sbjct: 4837 AEADDGGQGEDKINEQIDERDYDENEVD------------------PYHGNQEKV----P 4874

Query: 233  EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 292
            E E  D  ++ ++   D +    +   +E + E  + I+EKP+E   E      E++G  
Sbjct: 4875 EPEALDLPDDLNLDSED-KNGGEDTDNEEGEEENPLEIKEKPEEAGHE-----AEERGET 4928

Query: 293  VEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAA 352
               + ES  P          EPEE     +   G+  ++     +   A + PE  +E  
Sbjct: 4929 ETDQNESQSP---------QEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQ 4979

Query: 353  EASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEE 412
            + S  E   E  E+ G+           NGP+  G Q P E +   +  TE +    LE 
Sbjct: 4980 QQSVEEKDKEADEEGGE-----------NGPADQGFQ-PQEEEEREDSDTEEQVPEALER 5027

Query: 413  KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQ-----GATEKSPEDK------VQIAAN 461
            K  A    +  E   + +  E AG   + +  +     GA + +  +        Q+A+ 
Sbjct: 5028 KEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQ 5087

Query: 462  EETQEREEQMKE-----GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLE 516
            + T++  +  K        E    + +++ + +   +  DS  E    Q+ + +      
Sbjct: 5088 KHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQV----- 5142

Query: 517  LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCL---NLQE 573
               +  D  + I +  +  +AQ Y   +  K  + S +     Q  EE +  L     QE
Sbjct: 5143 ---EDADAFEHIKQGSDAYDAQTYDVAS--KEQQQSAKDSGKDQEEEEIEDTLMDTEEQE 5197

Query: 574  QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633
            ++  A    L     + G        +DE   +  ++++  E++    ++  KE E    
Sbjct: 5198 EFKAADVEQLKPEEIKSGTTAPLG--FDEMEVEI-QTVKTEEDQDPRTDKAHKETENEKP 5254

Query: 634  EYKKE------------------IEELKELLPEIREKIEDAKESQRSGNVAELALKATLV 675
            E  +E                  ++++ EL  E+  ++E   + + SGN  E  + A + 
Sbjct: 5255 ERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQLE-MWQPRESGNPEEEKVAAEMW 5313

Query: 676  ES 677
            +S
Sbjct: 5314 QS 5315



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 84/387 (21%), Positives = 156/387 (40%), Gaps = 55/387 (14%)

Query: 111  EGVHVEEEEGEKTEDESLVENNDNID--EEAREELREQVYDAMGEKEEAKKTEDKSLAKP 168
            E + + ++    +ED++  E+ DN +  EE   E++E+  +A  E EE  +TE       
Sbjct: 4877 EALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETD----- 4931

Query: 169  ETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVT 228
            + + +   E E+G  ED        E +E++D        T  + + G A + P E    
Sbjct: 4932 QNESQSPQEPEEGPSED-----DKAEGEEEMD--------TGADDQDGDAAQHPEE---H 4975

Query: 229  SGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288
            S + +Q V + ++E    G +         G   QG      EE+    +EEQ    LE+
Sbjct: 4976 SEEQQQSVEEKDKEADEEGGE--------NGPADQGFQPQEEEEREDSDTEEQVPEALER 5027

Query: 289  Q--GTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 346
            +   +  +   E++  T + +++ G  PE++    E+ +G A   Q  G       ES  
Sbjct: 5028 KEHASCGQTGVENMQNT-QAMELAGAAPEKEQGKEEHGSGAADANQAEG------HESNF 5080

Query: 347  VTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKD 406
            +   A++    +       KPGQ           +    +GD         + +   T D
Sbjct: 5081 IAQLASQKHTRKNTQSFKRKPGQ----------ADNERSMGDH-----NERVHKRLRTVD 5125

Query: 407  GSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQE 466
                 E+  A+   +Q E   + E  +   D  D +    A+++  +       ++E +E
Sbjct: 5126 TDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEE 5185

Query: 467  REEQMKEGEETEGSEEDDKENDKTEEM 493
             E+ + + EE E  +  D E  K EE+
Sbjct: 5186 IEDTLMDTEEQEEFKAADVEQLKPEEI 5212



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 75/386 (19%), Positives = 145/386 (37%), Gaps = 52/386 (13%)

Query: 406  DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ 465
            +G G+ E    K V  Q   +  VE++   G   D +     ++   ED     A E ++
Sbjct: 4676 EGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDN----AIEMSE 4731

Query: 466  EREEQMKEGEETEGSEEDDKE--------------NDKTEEMPNDSVLENKSLQENEEEE 511
            + + +M +GE  E  E+D+K               N +  +  ++ +  +   +E+EEEE
Sbjct: 4732 DFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEE 4791

Query: 512  IGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 571
                E     +D           ++++L A   +L  G  + +     +  E+ ++  + 
Sbjct: 4792 DNKTEETGPGMD----------EEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADD 4841

Query: 572  QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 631
              Q  +  +  + E  Y       Y+   ++      +++++ ++    LN   ++  G 
Sbjct: 4842 GGQGEDKINEQIDERDYDENEVDPYHGNQEKVPE--PEALDLPDD----LNLDSEDKNGG 4895

Query: 632  SAEYKKEIEELKELLPEIREKIEDA-KESQRSGNVAELALKATLVESSTSGFTPGGGGSS 690
                 +E EE   L  EI+EK E+A  E++  G         T    S S   P  G S 
Sbjct: 4896 EDTDNEEGEEENPL--EIKEKPEEAGHEAEERGET------ETDQNESQSPQEPEEGPSE 4947

Query: 691  VSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDA--KKAKQEPEVNGGSGDA 748
                   +  D  +         H       PEE S  +  +  +K K+  E  G +G A
Sbjct: 4948 DDKAEGEEEMDTGADDQDGDAAQH-------PEEHSEEQQQSVEEKDKEADEEGGENGPA 5000

Query: 749  VPSGNEVSENMEEEAENQAESRAAVE 774
                    E   E+++ + +   A+E
Sbjct: 5001 DQGFQPQEEEEREDSDTEEQVPEALE 5026


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%)

Query: 154  KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213
            KE+   + DK L + E  +E+ +   K   +++    S+ + +E  +        TS + 
Sbjct: 1080 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1138

Query: 214  KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 273
            K     E    +  TS K +Q      +  S S +D++++ +   G+        S E+K
Sbjct: 1139 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1187

Query: 274  PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 333
             K V+E   +V     G       E+L  +V PV V  D+ +      EN   K +L + 
Sbjct: 1188 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1241

Query: 334  VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 393
            +   +   E+    + +  E      G +  E PG E      +   +  S    +    
Sbjct: 1242 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1299

Query: 394  PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 447
             +    +LT +   SG E+K + K    V  +   K+S E+SE +     GV  +V++  
Sbjct: 1300 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1359

Query: 448  TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503
             E+ P      K ++  N+ + +++++ +  +  E S  ++K N + EE   +   E + 
Sbjct: 1360 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419

Query: 504  LQENEEEE 511
             +E EEE+
Sbjct: 1420 EEEEEEED 1427



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%)

Query: 145  EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 204
            ++V D + +  E    +D+S    E DK+Q  +  +  ++  D  K   + +++ + + D
Sbjct: 917  KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 976

Query: 205  WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 248
               +  E  +    P+G  + +   T G            K + E+ D  E+ +  G   
Sbjct: 977  GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1036

Query: 249  DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304
            D  E+ + K G    ++K+ +++     K ++ S         ++ +  E    S D  +
Sbjct: 1037 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1091

Query: 305  KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 363
            K +++     E + ++S+    +   E   G     AEES E   +  +  S+ +    V
Sbjct: 1092 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1143

Query: 364  SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 420
             EK         K    +  S        + Q SI       +GS  E+K++     LV 
Sbjct: 1144 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1197

Query: 421  SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 473
            S           EA    V   V     +  PE+++       +I AN  +   E+   +
Sbjct: 1198 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1255

Query: 474  GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 532
             E  EG +   K+N   EE P D   +N+   E++ +   + +  +   L   K+     
Sbjct: 1256 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1312

Query: 533  ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 589
            E+ E +    + H ++       V SE+   +  +FQ    + E+  E+ D     T   
Sbjct: 1313 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1366

Query: 590  LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 645
                            + +K  E+ EN+ +   +    ++K  E SS+E K   EE +E 
Sbjct: 1367 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1410

Query: 646  LPEIREKIEDAKESQRSGN 664
              E  E+ E+ +E +   N
Sbjct: 1411 KEEEEEEEEEEEEEEEDEN 1429



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%)

Query: 175  DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232
            D  + K     +D      +P+ ++   + L+ +       + G++ + P E +  +GK 
Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268

Query: 233  EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288
             +E P  EE K    S S +D +E  + +         +   + +  E  + +P    E 
Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1328

Query: 289  QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348
            +G                          + V+SE+       E  V +EV  +E+     
Sbjct: 1329 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365

Query: 349  TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 408
            T +A+ + +E      ++  +   +  ++                     +  +E K  S
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1404

Query: 409  GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 463
              EE+ +      +EE +   EE E   D  D   + G   K       +DK++      
Sbjct: 1405 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1458

Query: 464  TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 510
             +E EE+ K   E E   E  +E  + E+  P    +  K + + +EE
Sbjct: 1459 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1506



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 108  NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 167
            N+ E    +EEE E+ E+E   E ++N D ++  + R+++   +  K++  +TE ++  K
Sbjct: 1403 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1460

Query: 168  PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
             E + +++ +E E+   +  ++ +  +    K  +T   + +  EE K
Sbjct: 1461 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1508



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%)

Query: 153  EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 206
            +K ++ K+   S  K +T  E    DSE+EK   E   +SK  +A   ++++  T D+  
Sbjct: 755  KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 811

Query: 207  TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 266
            +E  + +K G   +G    + +      +    +E ++ S  +        G  +K   +
Sbjct: 812  SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 863

Query: 267  IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326
            +   +  PK+         ++K  +  E    SL+  V+ V     E +EK    + +  
Sbjct: 864  MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 916

Query: 327  KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 379
            K V + L  + ++    ++S E + +  + S  + G+E  +KP      + K     + +
Sbjct: 917  KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 974

Query: 380  VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 437
             +G   + ++  I   P+   +    T DG    +K+R K    ++E     E+S   GD
Sbjct: 975  SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1034

Query: 438  GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 493
              D+    K   GA  +   +K +     ++  + +     +  + S ++D  N   + +
Sbjct: 1035 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1091

Query: 494  PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 542
                + E ++L  +   +EI +   + D  + ++   K+++           KE +  + 
Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1151

Query: 543  QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 598
            +   K  +  + S +     ++ Q+ +   +  EQ ++   + L+  +H     + G   
Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1208

Query: 599  QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 637
              DEA+   SKS+ V           ENR+A  +L E++K     + +GSS     E KK
Sbjct: 1209 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1263

Query: 638  EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 686
               +  E  P   E + ++      D++ES++      L      V    SG    T   
Sbjct: 1264 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1323

Query: 687  GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 739
                V     RK +   S  +   +           +E+ PR   AKKA+ E        
Sbjct: 1324 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1383

Query: 740  -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774
                   +V   S     S +E  E  +EE E + E     E
Sbjct: 1384 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query: 122  KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 180
            K +++S  EN  N +EE  E+  E+  +   E+EE  + +D KS  K      +  + +K
Sbjct: 1391 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450

Query: 181  GGREDMDISKSAEEPQEKV 199
               E  +  K  EE ++++
Sbjct: 1451 LRTETQNALKEEEERRKRI 1469


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/368 (21%), Positives = 153/368 (41%), Gaps = 30/368 (8%)

Query: 154  KEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEA 213
            KE+   + DK L + E  +E+ +   K   +++    S+ + +E  +        TS + 
Sbjct: 1118 KEDGCNSSDKRLKRIEL-RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK 1176

Query: 214  KGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEK 273
            K     E    +  TS K +Q      +  S S +D++++ +   G+        S E+K
Sbjct: 1177 KAVIVKEKKRNSLRTSTKRKQA-----DITSSSSSDIEDDDQNSIGEGS------SDEQK 1225

Query: 274  PKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQL 333
             K V+E   +V     G       E+L  +V PV V  D+ +      EN   K +L + 
Sbjct: 1226 IKPVTEN--LVLSSHTGFCQSSGDEALSKSV-PVTVDDDDDDND---PENRIAKKMLLEE 1279

Query: 334  VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIE 393
            +   +   E+    + +  E      G +  E PG E      +   +  S    +    
Sbjct: 1280 IKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1337

Query: 394  PQTSIERLTETKDGSGLEEKVRAKL---VPSQEETKLSVEESEAAG---DGVDTKVAQGA 447
             +    +LT +   SG E+K + K    V  +   K+S E+SE +     GV  +V++  
Sbjct: 1338 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1397

Query: 448  TEKSPED----KVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503
             E+ P      K ++  N+ + +++++ +  +  E S  ++K N + EE   +   E + 
Sbjct: 1398 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457

Query: 504  LQENEEEE 511
             +E EEE+
Sbjct: 1458 EEEEEEED 1465



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 111/559 (19%), Positives = 213/559 (38%), Gaps = 85/559 (15%)

Query: 145  EQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLD 204
            ++V D + +  E    +D+S    E DK+Q  +  +  ++  D  K   + +++ + + D
Sbjct: 955  KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 1014

Query: 205  WLTETSEEAKGGAAPEGPNEAE--VTSG------------KPEQEVPDAEEEKSVSG--T 248
               +  E  +    P+G  + +   T G            K + E+ D  E+ +  G   
Sbjct: 1015 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1074

Query: 249  DVQEECREKGG----QEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304
            D  E+ + K G    ++K+ +++     K ++ S         ++ +  E    S D  +
Sbjct: 1075 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD-----TEKYSMKEDGCNSSDKRL 1129

Query: 305  KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE-ASAVEAGSEV 363
            K +++     E + ++S+    +   E   G     AEES E   +  +  S+ +    V
Sbjct: 1130 KRIEL----RERRNLSSK----RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIV 1181

Query: 364  SEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVR---AKLVP 420
             EK         K    +  S        + Q SI       +GS  E+K++     LV 
Sbjct: 1182 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI------GEGSSDEQKIKPVTENLVL 1235

Query: 421  SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKV-------QIAANEETQEREEQMKE 473
            S           EA    V   V     +  PE+++       +I AN  +   E+   +
Sbjct: 1236 SSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--EDGSSD 1293

Query: 474  GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW-DMLDLAKIIFKRQ 532
             E  EG +   K+N   EE P D   +N+   E++ +   + +  +   L   K+     
Sbjct: 1294 DEPEEGKKRTGKQN---EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDG 1350

Query: 533  ETKEAQLYAAQAHLKL---GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQ 589
            E+ E +    + H ++       V SE+   +  +FQ    + E+  E+ D     T   
Sbjct: 1351 ESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS--DFQES-GVSEEVSESEDEQRPRT--- 1404

Query: 590  LGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE----QVKEAEGSSAEYKKEIEELKEL 645
                            + +K  E+ EN+ +   +    ++K  E SS+E K   EE +E 
Sbjct: 1405 ----------------RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1448

Query: 646  LPEIREKIEDAKESQRSGN 664
              E  E+ E+ +E +   N
Sbjct: 1449 KEEEEEEEEEEEEEEEDEN 1467



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 63/348 (18%), Positives = 124/348 (35%), Gaps = 62/348 (17%)

Query: 175  DSEMEKGGREDMDISKSAEEPQEKV--DLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232
            D  + K     +D      +P+ ++   + L+ +       + G++ + P E +  +GK 
Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1306

Query: 233  EQEVPDAEEEK----SVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEK 288
             +E P  EE K    S S +D +E  + +         +   + +  E  + +P    E 
Sbjct: 1307 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1366

Query: 289  QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348
            +G                          + V+SE+       E  V +EV  +E+     
Sbjct: 1367 KGR-----------------------NRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403

Query: 349  TEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS 408
            T +A+ + +E      ++  +   +  ++                     +  +E K  S
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQE---------------------DSSSENKSNS 1442

Query: 409  GLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKS-----PEDKVQIAANEE 463
              EE+ +      +EE +   EE E   D  D   + G   K       +DK++      
Sbjct: 1443 EEEEEEK------EEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1496

Query: 464  TQEREEQMKEGEETEGSEEDDKENDKTEE-MPNDSVLENKSLQENEEE 510
             +E EE+ K   E E   E  +E  + E+  P    +  K + + +EE
Sbjct: 1497 LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1544



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 24/108 (22%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 108  NALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAK 167
            N+ E    +EEE E+ E+E   E ++N D ++  + R+++   +  K++  +TE ++  K
Sbjct: 1441 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNALK 1498

Query: 168  PETD-KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
             E + +++ +E E+   +  ++ +  +    K  +T   + +  EE K
Sbjct: 1499 EEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1546



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 138/702 (19%), Positives = 271/702 (38%), Gaps = 111/702 (15%)

Query: 153  EKEEAKKTEDKSLAKPETDKEQ---DSEMEKGGREDMDISK--SAEEPQEKVDLTLDW-L 206
            +K ++ K+   S  K +T  E    DSE+EK   E   +SK  +A   ++++  T D+  
Sbjct: 793  KKGKSAKSSIISKKKRQTQSESSNYDSELEK---EIKSMSKIGAARTTKKRIPNTKDFDS 849

Query: 207  TETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEV 266
            +E  + +K G   +G    + +      +    +E ++ S  +        G  +K   +
Sbjct: 850  SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE--------GTVDKDTTI 901

Query: 267  IVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAG 326
            +   +  PK+         ++K  +  E    SL+  V+ V     E +EK    + +  
Sbjct: 902  MELRDRLPKKQQASASTDGVDKL-SGKEQSFTSLE--VRKVA----ETKEKSKHLKTKTC 954

Query: 327  KAVLEQL--VGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPK-----DGA 379
            K V + L  + ++    ++S E + +  + S  + G+E  +KP      + K     + +
Sbjct: 955  KKVQDGLSDIAEKFLKKDQSDETSEDDKKQS--KKGTEEKKKPSDFKKKVIKMEQQYESS 1012

Query: 380  VNGPSVVGDQTPI--EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGD 437
             +G   + ++  I   P+   +    T DG    +K+R K    ++E     E+S   GD
Sbjct: 1013 SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD 1072

Query: 438  GVDT----KVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEM 493
              D+    K   GA  +   +K +     ++  + +     +  + S ++D  N   + +
Sbjct: 1073 SCDSSEDKKSKNGAYGR---EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1129

Query: 494  PNDSVLENKSL-QENEEEEIGNLELAWDMLDLAKIIFKRQE----------TKEAQLYAA 542
                + E ++L  +   +EI +   + D  + ++   K+++           KE +  + 
Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1189

Query: 543  QAHLKLGEVSVESENYVQAVEEFQSCL---NLQEQYLE-AHDRLLAETHYQLGLAYGYNS 598
            +   K  +  + S +     ++ Q+ +   +  EQ ++   + L+  +H     + G   
Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG--- 1246

Query: 599  QYDEAVAQFSKSIEVI----------ENRMA--VLNEQVK-----EAEGSS----AEYKK 637
              DEA+   SKS+ V           ENR+A  +L E++K     + +GSS     E KK
Sbjct: 1247 --DEAL---SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK 1301

Query: 638  EIEELKELLP---EIREKI-----EDAKESQRSGNVAELALKATLVESSTSG---FTPGG 686
               +  E  P   E + ++      D++ES++      L      V    SG    T   
Sbjct: 1302 RTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1361

Query: 687  GGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEP------- 739
                V     RK +   S  +   +           +E+ PR   AKKA+ E        
Sbjct: 1362 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1421

Query: 740  -------EVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVE 774
                   +V   S     S +E  E  +EE E + E     E
Sbjct: 1422 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query: 122  KTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTED-KSLAKPETDKEQDSEMEK 180
            K +++S  EN  N +EE  E+  E+  +   E+EE  + +D KS  K      +  + +K
Sbjct: 1429 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488

Query: 181  GGREDMDISKSAEEPQEKV 199
               E  +  K  EE ++++
Sbjct: 1489 LRTETQNALKEEEERRKRI 1507


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 68/296 (22%), Positives = 116/296 (39%), Gaps = 10/296 (3%)

Query: 116  EEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---KPETDK 172
            E  +   + D+  +  + ++DEE  E  RE+  D      E  K + K +    +P    
Sbjct: 968  EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL 1027

Query: 173  EQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKP 232
            E DS  E+  +E +   + + E +E+ +   +   +  +++      E  +E    S   
Sbjct: 1028 ELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEAS 1087

Query: 233  EQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTA 292
            E++  D++EE++VS    + E        +  E   S E  P    +E+ VV  E++   
Sbjct: 1088 EKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEE 1147

Query: 293  VEVE--AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG--QEVPPAEESPEVT 348
             E E  AE    +  P D   D  E  +           +E+ V    E    EE P + 
Sbjct: 1148 EEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSML 1207

Query: 349  TEAAEASAVEAGSEVSEKPGQEAPVLPKDGA-VNGPSVVGDQTPIEPQTSIERLTE 403
             E      VE  ++  E P  E P L ++GA +  P     +    P  S ER  E
Sbjct: 1208 DEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPE 1261



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 79/294 (26%), Positives = 120/294 (40%), Gaps = 42/294 (14%)

Query: 120  GEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQD---- 175
            GE+ E ESL E  ++ +EE  EE  E       E+EE    +D S  + E++ + +    
Sbjct: 1033 GEEDEKESLSEEQESTEEE--EEAEE-------EEEEEDDDDDDSDDRDESENDDEDTAL 1083

Query: 176  SEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQE 235
            SE  +    D D  ++      K + T      +S E+   +  E  +E+  +S + E+E
Sbjct: 1084 SEASEKDEGDSDEEETVSIVTSKAEAT------SSSESSESSEFESSSESSPSSSEDEEE 1137

Query: 236  VPDAEEEKSVSGTD-VQEECREKGGQ---EKQGEVIVSIEEKPKEVS---EEQPVVTLEK 288
            V   EEE+     + V EE     G    E+ GE        P   S   EE+  V +E 
Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEE--VDIET 1195

Query: 289  QGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVT 348
            +  A E     LD    P+ VG +EP +     E E G +    ++    PPA+E  E  
Sbjct: 1196 EAVAPEERPSMLDE--PPLPVGVEEPADSREPPE-EPGLSQEGAMLLSPEPPAKE-VEAR 1251

Query: 349  TEAAEASAVEAGSEVSEKPGQEAPV-----LPKDGAVNGPSVVGDQTPIEPQTS 397
               +   A E   EV  +P    P+     LP       PS      P EP+T+
Sbjct: 1252 PPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPS-----PPPEPETT 1300



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 75/333 (22%), Positives = 121/333 (36%), Gaps = 45/333 (13%)

Query: 102  ENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE 161
            E   L    E    EEE  E+ E+E   +++ +  +E+  +  +       EK+E    E
Sbjct: 1037 EKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDE 1096

Query: 162  DKSL----AKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEE--AKG 215
            ++++    +K E     +S          + S S+ E +E+V    +   E  EE  A+ 
Sbjct: 1097 EETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEE 1156

Query: 216  GAAPEGP-------NEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR------------- 255
              A  GP        EA +  G P  +    EEE  +    V  E R             
Sbjct: 1157 SMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGV 1216

Query: 256  ----------EKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVK 305
                      E+ G  ++G +++S E   KEV    P+         +EVE E   P + 
Sbjct: 1217 EEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPE--PPMML 1274

Query: 306  PVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP---AEESPEVTTEAAEASAVEAGSE 362
            P+ +    P  +     +   +          VPP   AE+ P  T     + A    +E
Sbjct: 1275 PLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTE 1334

Query: 363  -VSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEP 394
             V   PG E P+    G  +G S+   Q P  P
Sbjct: 1335 TVPATPGGEPPL---SGGSSGLSLSSPQVPGSP 1364



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 47/202 (23%), Positives = 93/202 (46%), Gaps = 25/202 (12%)

Query: 387  GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQG 446
            GDQ  + P TS++   E  +     E+ R        +T   + + +  G GV  + A+ 
Sbjct: 976  GDQKRLRPSTSVDEEDEESE----RERDR-----DMADTPCELAKRDPKGVGVRRRPARP 1026

Query: 447  ATEKS---PEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKS 503
                S    ++K  ++  +E+ E EE+ +E EE E  ++DD ++D  +E  ND   E+ +
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEE--DDDDDDSDDRDESENDD--EDTA 1082

Query: 504  LQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVE 563
            L E  E++ G+     D  +   I+     T +A+  ++    +  E    SE+   + E
Sbjct: 1083 LSEASEKDEGDS----DEEETVSIV-----TSKAEATSSSESSESSEFESSSESSPSSSE 1133

Query: 564  EFQSCLNLQEQYLEAHDRLLAE 585
            + +  +  +E+  E  + ++AE
Sbjct: 1134 DEEEVVAREEEEEEEEEEMVAE 1155



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 54/263 (20%)

Query: 259  GQEKQGEVIVSIEEKPKEVSEEQ-------PVVTLEKQGTAVEVEAESLDPTVKPVDVGG 311
            G +K+     S++E+ +E   E+       P    ++    V V      P    +D GG
Sbjct: 976  GDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL--ELDSGG 1033

Query: 312  DEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEA 371
            +E E++ ++ E E+                       TE  E    EA  E  E+   + 
Sbjct: 1034 EEDEKESLSEEQES-----------------------TEEEE----EAEEEEEEEDDDDD 1066

Query: 372  PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE 431
                +D + N           +  T++   +E  +G   EE+    +V S+ E   S E 
Sbjct: 1067 DSDDRDESEND----------DEDTALSEASEKDEGDSDEEET-VSIVTSKAEATSSSES 1115

Query: 432  SEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE---TEGSEEDDKEND 488
            SE++    + + +  ++  S ED+ ++ A EE +E EE+    EE   + G E+ +++ +
Sbjct: 1116 SESS----EFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGE 1171

Query: 489  KTEEMPNDSVLENKSLQENEEEE 511
            +    P    +++  ++E  + E
Sbjct: 1172 EAALAPGAPAVDSLGMEEEVDIE 1194


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 112/543 (20%), Positives = 225/543 (41%), Gaps = 76/543 (13%)

Query: 135 IDEEAREELREQVYD-AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAE 193
           ++ +  EELR++     M   E  K+ +D    K + D++ +   E+ G    D+S    
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG----DLSFKLR 328

Query: 194 EPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEE 253
           E    +    D L E +EE            ++ T    E++   A+ EK +S     ++
Sbjct: 329 EFASHLQQLQDALNELTEE-----------HSKATQEWLEKQ---AQLEKELSAALQDKK 374

Query: 254 CREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDE 313
           C E+  +  QG+ +  +EE   ++ +  P    E  G  +++E  +L      +     +
Sbjct: 375 CLEEKNEILQGK-LSQLEEHLSQLQDNPPQEKGEVLGDVLQLE--TLKQEAATLAANNTQ 431

Query: 314 PEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA-SAVEAGSEVSEKPGQEAP 372
            + +V   E E G+   + L+ +     EE  ++++   +  S++   S+  E+  Q + 
Sbjct: 432 LQARVEMLETERGQQEAK-LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ 490

Query: 373 VLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES 432
                      S+  + T +    +I++  + ++ +GL+++ + K    Q +   ++++ 
Sbjct: 491 AHGARLTAQVASLTSELTTLN--ATIQQ--QDQELAGLKQQAKEK----QAQLAQTLQQQ 542

Query: 433 EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKE-GEETEGSEEDDKENDKTE 491
           E A  G+  +V Q               +   +++E+Q+KE  E+ E + +D  +   T 
Sbjct: 543 EQASQGLRHQVEQ--------------LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588

Query: 492 EMPNDSVLEN-----KSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHL 546
               ++ L       K L+  E+E+   LE+    L +A      +    AQ    QA  
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-----EARDSAQTSVTQAQR 643

Query: 547 KLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQ 606
           +  E+S       + VEE Q+C+    Q        +AE   QL  +    +   E VAQ
Sbjct: 644 EKAELS-------RKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQ 695

Query: 607 FSKSIEVIENRMAVLNEQVKEAEGSSAEYKKE----IEE----LKELLPEIREKIEDAKE 658
                + ++ ++  L E +K  +GS  E K+     +EE    + EL  E R  +E  K 
Sbjct: 696 ---EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752

Query: 659 SQR 661
            ++
Sbjct: 753 ERK 755



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 126/636 (19%), Positives = 243/636 (38%), Gaps = 109/636 (17%)

Query: 113  VHVEEEEGEKTEDESLVENNDNIDEEAR-------------EELREQVYDAMGEKEEA-- 157
            + +  E+ + TE E + +  D + E+ +             EE + +  DA+ E++    
Sbjct: 678  LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737

Query: 158  -KKTEDKSLAKPETDKEQDSEMEKGGREDMD--ISKSAEEPQEKVDLTLDWLTET----- 209
              K E +SL +    + ++ E E+ GR+ ++  + +  E  Q + ++    L E      
Sbjct: 738  ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797

Query: 210  ------------------------SEEAKGGAA-PEGPNEAEVTSGKPEQEVPDAEEEKS 244
                                     EEA+ GA   E     +    K  QE+ +A+E+  
Sbjct: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-- 855

Query: 245  VSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTV 304
            V+G +   E +    Q +  E+  ++    ++V E++  V  +K    +    E +  T 
Sbjct: 856  VAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLSTLQEKMAATS 913

Query: 305  KPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTE------AAEASAVE 358
            K V        E +V    E  +    +LV +     +  PE   E       +  +A++
Sbjct: 914  KEV-----ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968

Query: 359  AGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGS----GLEEKV 414
            A    +E+ G E   L    A+        +   + +  + RLT+ +  +     LE+  
Sbjct: 969  AMEREAEQMGNELERLR--AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026

Query: 415  RAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDK----------VQIAANEET 464
            RA+L   +   + ++ E       +   +A   TEK  +D+           QI   EE 
Sbjct: 1027 RAEL---EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083

Query: 465  QEREEQMKEG------EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELA 518
            ++  +Q+KE       E   GS    +   +TE  P    LE    + ++ E+    +  
Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE--PTGPKLEALRAEVSKLEQ--QCQKQ 1139

Query: 519  WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEA 578
             +  D  +   + +    A+  +A     L  +  + E   Q +   QS L   ++ L A
Sbjct: 1140 QEQADSLERSLEAERASRAERDSA-----LETLQGQLEEKAQELGHSQSALASAQRELAA 1194

Query: 579  -----HDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 633
                  D   AE  ++  +A G      +   + +  I  +E  +++LN QV E EG S 
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGR-----QEAERKNSLISSLEEEVSILNRQVLEKEGESK 1249

Query: 634  EYKKEIEELKELLPEIREKIE--DAKESQRSGNVAE 667
            E K+ +    E   ++ E++    A+ +  S   AE
Sbjct: 1250 ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 119/692 (17%), Positives = 264/692 (38%), Gaps = 92/692 (13%)

Query: 115  VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET-DKE 173
            VE+      + E  ++      E  R++  +Q+  A  E+E + +  D +L + E  +KE
Sbjct: 553  VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 174  QDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSG 230
            + +++E   ++    +++ +  Q  V        E S   EE +         + E  + 
Sbjct: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672

Query: 231  KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI---VSIEEKPKEVSEEQPVVTLE 287
              E E+    E++    T+ +   +EK   ++Q + +   + + +   E  + +    LE
Sbjct: 673  VAELELQLRSEQQ--KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730

Query: 288  KQGTAV-EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPE 346
            +Q   + E++AE+         +      E+    E  AG+  LE  + Q     +   E
Sbjct: 731  EQQRCISELKAETR-------SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783

Query: 347  V-TTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSI--ERLTE 403
            V   E AEA A +  +E       E   L K+ A         Q       ++  E+L  
Sbjct: 784  VLRRELAEAMAAQHTAE------SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 404  TKDGSGLEEKVRAKL---------VPSQEETKLSVEESEAAGDGVD-TKVAQGATEKSPE 453
             K+     EK R +L         + S  E ++S +++E A    +  +  Q   EK  E
Sbjct: 838  LKEEC---EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK--E 892

Query: 454  DKVQIAANEETQEREEQMKEGEET---------EGSEEDDKENDKTEEMPNDSVLENKSL 504
             + Q  A++ +  +E+     +E           G +++    +  +E       + + L
Sbjct: 893  VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952

Query: 505  QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 564
            +E +  +  + + A           +  E +  Q+      L+   +  + +   +  ++
Sbjct: 953  EEQQGRQFCSTQAA----------LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002

Query: 565  FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV---L 621
             +    L ++   A   L  E   +  L     +  +E   +F+   E + + +      
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062

Query: 622  NEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSG 681
            ++++ +  G  A   KE+EEL++ + +++E++   ++   SG+ A+              
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ-------------- 1108

Query: 682  FTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEV 741
                      S  A R    G        ++S L ++ +K +E++   + + +A++    
Sbjct: 1109 ----------SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158

Query: 742  NGGSGDAVPSGNEVSENMEEEAENQAESRAAV 773
               S      G      +EE+A+    S++A+
Sbjct: 1159 ERDSALETLQG-----QLEEKAQELGHSQSAL 1185



 Score = 37.0 bits (84), Expect = 0.071
 Identities = 104/531 (19%), Positives = 203/531 (38%), Gaps = 87/531 (16%)

Query: 1    MAMESTATAAVAAELVSADKI-EDVPAPSTSADK-----------------VESLDVDSE 42
            + +E T+T A+ +EL+ A  + + + A   +A+K                  E L    E
Sbjct: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405

Query: 43   AKKLLGLGQK----HLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLEL 98
              +L+ L QK          + A   ++ E  S+L K +G  A E         + L E 
Sbjct: 1406 LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE--------NRGLGER 1457

Query: 99   ARMENGVLGNALEGV---HVEEEEGEKTEDESLVENNDNIDEEAREELRE-QVYDAMGEK 154
            A +    L   L+     +V+E    + + E+ +     +  EA+   RE +V  A  E 
Sbjct: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE---VQREAQSTARELEVMTAKYEG 1514

Query: 155  EEAKKTEDKSLAKPETDK-------------EQDSEMEKGGREDMDISKSAEEPQEKVDL 201
             + K  E++   + E  K             EQ  ++E+  ++  D  ++++  Q+K+  
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574

Query: 202  TLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTD--------VQEE 253
                  E+ +EA+   A     +A+++  +   E    + EK+ +  D        +QE+
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634

Query: 254  CREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAE--SLDPTVKPV---- 307
             R     +K+ + + +  E+     ++  + T E + T   + A+  SL+  V       
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694

Query: 308  -DVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEK 366
             D+G  +     + S     K  L+  +       EE   ++  +        G+ V  +
Sbjct: 1695 RDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGE 1754

Query: 367  P----GQEAPVLPKDGAVNG----PSVVGDQTPIEPQTSIERLTETKDGSGLE----EKV 414
            P     Q  P  PK  ++      P     Q P+E  +S++ L +    SG +     + 
Sbjct: 1755 PASPISQRLP--PKVESLESLYFTPIPARSQAPLE--SSLDSLGDVFLDSGRKTRSARRR 1810

Query: 415  RAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ 465
              +++      KL VEE ++A           +T  +P  +  + A   TQ
Sbjct: 1811 TTQIINITMTKKLDVEEPDSANSSF------YSTRSAPASQASLRATSSTQ 1855


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)

Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166
           EEE E +E+ S  E        ++ +  E++         AK T  K             
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326

Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217
                  KPE D E  SE      E+   +K+  + +   K            E  + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386

Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272
           AP      GP  A+  +GK E++   + EE S S  +   + +  G   +        +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445

Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332
            P++ +   P     K G           P    V VG  E + +  + E+++ +  L  
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392
           +   +V P  +SP+V   +               PG+  P          PS    +   
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543

Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452
           + ++S E  +++ DG     +V   + P+QE++  ++ +++       +  A+G  +K+ 
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593

Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
              VQ+ A E+  +  E  +E  ++  SEE        +  P   + + K+  +      
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652

Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572
                       AK+   R  T +A   A  A    G     +    +  E+  S    +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697

Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627
           E   E     LA T  Q   + G   Q   A      S+      V+  +      QVK 
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756

Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687
            +   +E  +E  + +E      +     K++Q   N A  A +A   + + S   PG  
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812

Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747
            ++ +    R P+          + + L R              A +A+  PE + GS  
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870

Query: 748 AVPSGNEVSENMEEEAENQAE 768
                +E   + EEEAE  A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)

Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185
           R EL   +Y  +   G    A++ +++S     LA+P T        +Q SE+ +  + +
Sbjct: 7   RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66

Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245
            D +  A++ +    ++    +E  EEA+   A   P  A   S     ++P + +EK+ 
Sbjct: 67  EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290
           + T+   +          G+ + ++   + P++ +E     TL    E++G         
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326
                +A + ++ S D             P+VKP  V        + P  K   +  + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246

Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371
             V  Q+ G  +PPA      EE  E + E +E+         S V+A  ++ +     A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429
           P     G    P+  G    +  QT   +  E  + S  E         S+EET    ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359

Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489
            +++A+G       A    ++SP      A   +T     + + G+  E S+   +E+D 
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 490 TEEMPNDSVLENKSLQ 505
            EE P  +    K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)

Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219
           T    + K E D E  SE E     D ++  +    QEK    +     TS  AKG    
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591

Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279
            GP   +V + KP            +  ++  EE  +    E+    + + + KP  +  
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638

Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339
            Q     +K  T    +       V PV VG   P  K  T+ + AG +    + G    
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688

Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390
           PAE+S       +E      AV  G   S   G +      PV    G    P + G   
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748

Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450
           P   Q   E+  +++      +   A   P+Q   K SV++++A  +    +        
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510
           S   KV  AA +  Q    ++K       +         +      +V      Q   EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866

Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547
           + G+ E   D  + A+ + + +   K  Q+ AA A  K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%)

Query: 12  AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70
           AA      ++ D  + S S+++ E  + ++ +A   L      ++  D+P+++   +E A
Sbjct: 69  AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125

Query: 71  SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130
               +K G+T N         GK++  L                     G+     +   
Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164

Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184
            N  +  E  EE     + A  +       +    +ED S +  ETD E    ++    +
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224

Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241
              +S + E P  K       + + + + KGGA P         + KPE+E   +EE   
Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278

Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296
             E++ +GT  Q +  EK  Q +        +  P + +   P      +  Q  A + E
Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336

Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356
            +S   + +  D   + P  K +     +GK      VG    PA+ESP      A    
Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390

Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416
                     PG+  P + K  A  G      Q+  E   S E        SG   +VRA
Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476
              P++E  +                  +GA    P      AA         Q++ G++
Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471

Query: 477 TEGSEEDDKENDKTEE 492
            E S    +E+D   E
Sbjct: 472 EEDSRSSSEESDSDRE 487



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)

Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425
           K  ++A +  K   V+ P    + +  E +   E    T   +     V    +PS  + 
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466
           K   E  +A   G           VA   + KSP    + +AN     ET+E        
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183

Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521
              +   +  G+    SE+    +D+T  E  P+    + K+   + +E           
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242

Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581
               K+     + K   L  A+   K  E S  SE   ++ EE  +    Q   ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296

Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641
           +L +       A G   +               + +     E  + +   S++ ++E   
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355

Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698
            K LL         AK S ++  V   A  A   ES   G  P   G  G +V+   + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405

Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748
             + + SS+  +D       + KP  ++P+        K+  +K  A   P   G +   
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773
           V  G   E S +  EE+++  E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)

Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683
           QVK      A+  K+ EE  E   E  E  E+A    RS   A   +      S+ +  T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310

Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721
           PG G         G+  S   + KP + + SS+  +  S         L++ K       
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370

Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770
                 P +ESPRK  A      P   G +G AV         E S++  EE++++ E+ 
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 771 AAVEGTVEA 779
           A  + + +A
Sbjct: 425 AQAKPSGKA 433



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)

Query: 152  GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207
            GE  EA    +KT   S  K + DK      EK G+  +    + +EP+E++        
Sbjct: 1333 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1385

Query: 208  ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267
                  KG    EG +++   S K +++    +++K       +++ + K    K  E  
Sbjct: 1386 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1435

Query: 268  VSIEEKPKEVSEEQPV 283
               ++K K+ + EQ V
Sbjct: 1436 SQKKKKKKKKTAEQTV 1451


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)

Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166
           EEE E +E+ S  E        ++ +  E++         AK T  K             
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326

Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217
                  KPE D E  SE      E+   +K+  + +   K            E  + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386

Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272
           AP      GP  A+  +GK E++   + EE S S  +   + +  G   +        +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445

Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332
            P++ +   P     K G           P    V VG  E + +  + E+++ +  L  
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392
           +   +V P  +SP+V   +               PG+  P          PS    +   
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543

Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452
           + ++S E  +++ DG     +V   + P+QE++  ++ +++       +  A+G  +K+ 
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593

Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
              VQ+ A E+  +  E  +E  ++  SEE        +  P   + + K+  +      
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652

Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572
                       AK+   R  T +A   A  A    G     +    +  E+  S    +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697

Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627
           E   E     LA T  Q   + G   Q   A      S+      V+  +      QVK 
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756

Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687
            +   +E  +E  + +E      +     K++Q   N A  A +A   + + S   PG  
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812

Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747
            ++ +    R P+          + + L R              A +A+  PE + GS  
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870

Query: 748 AVPSGNEVSENMEEEAENQAE 768
                +E   + EEEAE  A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)

Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185
           R EL   +Y  +   G    A++ +++S     LA+P T        +Q SE+ +  + +
Sbjct: 7   RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66

Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245
            D +  A++ +    ++    +E  EEA+   A   P  A   S     ++P + +EK+ 
Sbjct: 67  EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290
           + T+   +          G+ + ++   + P++ +E     TL    E++G         
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326
                +A + ++ S D             P+VKP  V        + P  K   +  + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246

Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371
             V  Q+ G  +PPA      EE  E + E +E+         S V+A  ++ +     A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429
           P     G    P+  G    +  QT   +  E  + S  E         S+EET    ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359

Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489
            +++A+G       A    ++SP      A   +T     + + G+  E S+   +E+D 
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 490 TEEMPNDSVLENKSLQ 505
            EE P  +    K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)

Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219
           T    + K E D E  SE E     D ++  +    QEK    +     TS  AKG    
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591

Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279
            GP   +V + KP            +  ++  EE  +    E+    + + + KP  +  
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638

Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339
            Q     +K  T    +       V PV VG   P  K  T+ + AG +    + G    
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688

Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390
           PAE+S       +E      AV  G   S   G +      PV    G    P + G   
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748

Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450
           P   Q   E+  +++      +   A   P+Q   K SV++++A  +    +        
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510
           S   KV  AA +  Q    ++K       +         +      +V      Q   EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866

Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547
           + G+ E   D  + A+ + + +   K  Q+ AA A  K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%)

Query: 12  AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70
           AA      ++ D  + S S+++ E  + ++ +A   L      ++  D+P+++   +E A
Sbjct: 69  AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125

Query: 71  SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130
               +K G+T N         GK++  L                     G+     +   
Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164

Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184
            N  +  E  EE     + A  +       +    +ED S +  ETD E    ++    +
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224

Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241
              +S + E P  K       + + + + KGGA P         + KPE+E   +EE   
Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278

Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296
             E++ +GT  Q +  EK  Q +        +  P + +   P      +  Q  A + E
Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336

Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356
            +S   + +  D   + P  K +     +GK      VG    PA+ESP      A    
Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390

Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416
                     PG+  P + K  A  G      Q+  E   S E        SG   +VRA
Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476
              P++E  +                  +GA    P      AA         Q++ G++
Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471

Query: 477 TEGSEEDDKENDKTEE 492
            E S    +E+D   E
Sbjct: 472 EEDSRSSSEESDSDRE 487



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)

Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425
           K  ++A +  K   V+ P    + +  E +   E    T   +     V    +PS  + 
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466
           K   E  +A   G           VA   + KSP    + +AN     ET+E        
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183

Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521
              +   +  G+    SE+    +D+T  E  P+    + K+   + +E           
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242

Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581
               K+     + K   L  A+   K  E S  SE   ++ EE  +    Q   ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296

Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641
           +L +       A G   +               + +     E  + +   S++ ++E   
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355

Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698
            K LL         AK S ++  V   A  A   ES   G  P   G  G +V+   + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405

Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748
             + + SS+  +D       + KP  ++P+        K+  +K  A   P   G +   
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773
           V  G   E S +  EE+++  E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)

Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683
           QVK      A+  K+ EE  E   E  E  E+A    RS   A   +      S+ +  T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310

Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721
           PG G         G+  S   + KP + + SS+  +  S         L++ K       
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370

Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770
                 P +ESPRK  A      P   G +G AV         E S++  EE++++ E+ 
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 771 AAVEGTVEA 779
           A  + + +A
Sbjct: 425 AQAKPSGKA 433



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)

Query: 152  GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207
            GE  EA    +KT   S  K + DK      EK G+  +    + +EP+E++        
Sbjct: 1370 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1422

Query: 208  ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267
                  KG    EG +++   S K +++    +++K       +++ + K    K  E  
Sbjct: 1423 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1472

Query: 268  VSIEEKPKEVSEEQPV 283
               ++K K+ + EQ V
Sbjct: 1473 SQKKKKKKKKTAEQTV 1488



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 73/334 (21%), Positives = 122/334 (36%), Gaps = 47/334 (14%)

Query: 156  EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG 215
            +A  T  K+ A   T +   SE E    ED+  +     P  + ++       T   A  
Sbjct: 979  QAASTPRKARASESTARSSSSESED---EDVIPATQCLTPGIRTNVV------TMPTAHP 1029

Query: 216  GAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPK 275
              AP+  + A  +S K    + D ++++   G   Q   +           +  + +K  
Sbjct: 1030 RIAPKA-SMAGASSSKESSRISDGKKQE---GPATQVSKKNPASLPLTQAALKVLAQK-- 1083

Query: 276  EVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVG 335
              SE QP V   +  + V+    +L  T          P+    TS    G   L +   
Sbjct: 1084 -ASEAQPPVARTQPSSGVDSAVGTLPAT---------SPQS---TSVQAKGTNKLRKPKL 1130

Query: 336  QEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQ 395
             EV  A ++PE + ++ ++S   +GSE       E P   K     GP+    +T +E  
Sbjct: 1131 PEVQQATKAPESSDDSEDSSDSSSGSE----EDGEGPQGAKSAHTLGPTPSRTETLVEET 1186

Query: 396  T--SIERLTETKDGSGLEEKVRAKLVPSQE---------ETKLSVEESEAAGDGVD---- 440
               S E        S L   +   L P+           ++  SV  + AA D  D    
Sbjct: 1187 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1246

Query: 441  TKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474
             K  Q A   SP+   + AA+  T ++  + K+G
Sbjct: 1247 AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)

Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166
           EEE E +E+ S  E        ++ +  E++         AK T  K             
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326

Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217
                  KPE D E  SE      E+   +K+  + +   K            E  + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386

Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272
           AP      GP  A+  +GK E++   + EE S S  +   + +  G   +        +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445

Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332
            P++ +   P     K G           P    V VG  E + +  + E+++ +  L  
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392
           +   +V P  +SP+V   +               PG+  P          PS    +   
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543

Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452
           + ++S E  +++ DG     +V   + P+QE++  ++ +++       +  A+G  +K+ 
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593

Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
              VQ+ A E+  +  E  +E  ++  SEE        +  P   + + K+  +      
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652

Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572
                       AK+   R  T +A   A  A    G     +    +  E+  S    +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697

Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627
           E   E     LA T  Q   + G   Q   A      S+      V+  +      QVK 
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756

Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687
            +   +E  +E  + +E      +     K++Q   N A  A +A   + + S   PG  
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812

Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747
            ++ +    R P+          + + L R              A +A+  PE + GS  
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870

Query: 748 AVPSGNEVSENMEEEAENQAE 768
                +E   + EEEAE  A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)

Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185
           R EL   +Y  +   G    A++ +++S     LA+P T        +Q SE+ +  + +
Sbjct: 7   RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66

Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245
            D +  A++ +    ++    +E  EEA+   A   P  A   S     ++P + +EK+ 
Sbjct: 67  EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290
           + T+   +          G+ + ++   + P++ +E     TL    E++G         
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326
                +A + ++ S D             P+VKP  V        + P  K   +  + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246

Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371
             V  Q+ G  +PPA      EE  E + E +E+         S V+A  ++ +     A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429
           P     G    P+  G    +  QT   +  E  + S  E         S+EET    ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359

Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489
            +++A+G       A    ++SP      A   +T     + + G+  E S+   +E+D 
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 490 TEEMPNDSVLENKSLQ 505
            EE P  +    K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)

Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219
           T    + K E D E  SE E     D ++  +    QEK    +     TS  AKG    
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591

Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279
            GP   +V + KP            +  ++  EE  +    E+    + + + KP  +  
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638

Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339
            Q     +K  T    +       V PV VG   P  K  T+ + AG +    + G    
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688

Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390
           PAE+S       +E      AV  G   S   G +      PV    G    P + G   
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748

Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450
           P   Q   E+  +++      +   A   P+Q   K SV++++A  +    +        
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510
           S   KV  AA +  Q    ++K       +         +      +V      Q   EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866

Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547
           + G+ E   D  + A+ + + +   K  Q+ AA A  K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%)

Query: 12  AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70
           AA      ++ D  + S S+++ E  + ++ +A   L      ++  D+P+++   +E A
Sbjct: 69  AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125

Query: 71  SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130
               +K G+T N         GK++  L                     G+     +   
Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164

Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184
            N  +  E  EE     + A  +       +    +ED S +  ETD E    ++    +
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224

Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241
              +S + E P  K       + + + + KGGA P         + KPE+E   +EE   
Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278

Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296
             E++ +GT  Q +  EK  Q +        +  P + +   P      +  Q  A + E
Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336

Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356
            +S   + +  D   + P  K +     +GK      VG    PA+ESP      A    
Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390

Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416
                     PG+  P + K  A  G      Q+  E   S E        SG   +VRA
Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476
              P++E  +                  +GA    P      AA         Q++ G++
Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471

Query: 477 TEGSEEDDKENDKTEE 492
            E S    +E+D   E
Sbjct: 472 EEDSRSSSEESDSDRE 487



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)

Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425
           K  ++A +  K   V+ P    + +  E +   E    T   +     V    +PS  + 
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466
           K   E  +A   G           VA   + KSP    + +AN     ET+E        
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183

Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521
              +   +  G+    SE+    +D+T  E  P+    + K+   + +E           
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242

Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581
               K+     + K   L  A+   K  E S  SE   ++ EE  +    Q   ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296

Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641
           +L +       A G   +               + +     E  + +   S++ ++E   
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355

Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698
            K LL         AK S ++  V   A  A   ES   G  P   G  G +V+   + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405

Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748
             + + SS+  +D       + KP  ++P+        K+  +K  A   P   G +   
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773
           V  G   E S +  EE+++  E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)

Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683
           QVK      A+  K+ EE  E   E  E  E+A    RS   A   +      S+ +  T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310

Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721
           PG G         G+  S   + KP + + SS+  +  S         L++ K       
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370

Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770
                 P +ESPRK  A      P   G +G AV         E S++  EE++++ E+ 
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 771 AAVEGTVEA 779
           A  + + +A
Sbjct: 425 AQAKPSGKA 433



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 31/136 (22%), Positives = 57/136 (41%), Gaps = 21/136 (15%)

Query: 152  GEKEEA----KKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLT 207
            GE  EA    +KT   S  K + DK      EK G+  +    + +EP+E++        
Sbjct: 1332 GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ------- 1384

Query: 208  ETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVI 267
                  KG    EG +++   S K +++    +++K       +++ + K    K  E  
Sbjct: 1385 ------KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKK----EKKKKAKKASTKDSESP 1434

Query: 268  VSIEEKPKEVSEEQPV 283
               ++K K+ + EQ V
Sbjct: 1435 SQKKKKKKKKTAEQTV 1450


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 135/681 (19%), Positives = 239/681 (35%), Gaps = 90/681 (13%)

Query: 117 EEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLA---------- 166
           EEE E +E+ S  E        ++ +  E++         AK T  K             
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326

Query: 167 -------KPETDKEQDSEMEKGGREDMDISKSAEEPQE--KVDLTLDWLTETSEEAKGGA 217
                  KPE D E  SE      E+   +K+  + +   K            E  + GA
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386

Query: 218 APE-----GPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEE 272
           AP      GP  A+  +GK E++   + EE S S  +   + +  G   +        +E
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASAPAKE 445

Query: 273 KPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQ 332
            P++ +   P     K G           P    V VG  E + +  + E+++ +  L  
Sbjct: 446 SPRKGAAPAPP---RKTG-----------PAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 333 LVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPI 392
           +   +V P  +SP+V   +               PG+  P          PS    +   
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT--------PSAQVGKWEE 543

Query: 393 EPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP 452
           + ++S E  +++ DG     +V   + P+QE++  ++ +++       +  A+G  +K+ 
Sbjct: 544 DSESSSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAKPT-----SSPAKGPPQKAG 593

Query: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
              VQ+ A E+  +  E  +E  ++  SEE        +  P   + + K+  +      
Sbjct: 594 PVAVQVKA-EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA 652

Query: 513 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 572
                       AK+   R  T +A   A  A    G     +    +  E+  S    +
Sbjct: 653 S-----------AKVAPVRVGT-QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS---E 697

Query: 573 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-----EVIENRMAVLNEQVKE 627
           E   E     LA T  Q   + G   Q   A      S+      V+  +      QVK 
Sbjct: 698 ESDSEEEKTGLAVTVGQ-AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA 756

Query: 628 AEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGG 687
            +   +E  +E  + +E      +     K++Q   N A  A +A   + + S   PG  
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGTIS--APGKV 812

Query: 688 GSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGD 747
            ++ +    R P+          + + L R              A +A+  PE + GS  
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS-- 870

Query: 748 AVPSGNEVSENMEEEAENQAE 768
                +E   + EEEAE  A+
Sbjct: 871 -----SEEESDSEEEAETLAQ 886



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 77/436 (17%)

Query: 140 REELREQVYDAM---GEKEEAKKTEDKS-----LAKPET------DKEQDSEMEKGGRED 185
           R EL   +Y  +   G    A++ +++S     LA+P T        +Q SE+ +  + +
Sbjct: 7   RRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAE 66

Query: 186 MDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSV 245
            D +  A++ +    ++    +E  EEA+   A   P  A   S     ++P + +EK+ 
Sbjct: 67  EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 246 SGTDVQEECREKGGQEKQGEVIVSI--EEKPKEVSEEQPVVTL----EKQG--------- 290
           + T+   +          G+ + ++   + P++ +E     TL    E++G         
Sbjct: 127 AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA 186

Query: 291 -----TAVEVEAESLD-------------PTVKPVDVGG------DEPEEKVVTSENEAG 326
                +A + ++ S D             P+VKP  V        + P  K   +  + G
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG 246

Query: 327 KAVLEQLVGQEVPPA------EESPEVTTEAAEA---------SAVEAGSEVSEKPGQEA 371
             V  Q+ G  +PPA      EE  E + E +E+         S V+A  ++ +     A
Sbjct: 247 D-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKL--SV 429
           P     G    P+  G    +  QT   +  E  + S  E         S+EET    ++
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS------DSEEETPAAKAL 359

Query: 430 EESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDK 489
            +++A+G       A    ++SP      A   +T     + + G+  E S+   +E+D 
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 490 TEEMPNDSVLENKSLQ 505
            EE P  +    K+ Q
Sbjct: 420 EEEAPAQAKPSGKAPQ 435



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 87/398 (21%), Positives = 139/398 (34%), Gaps = 36/398 (9%)

Query: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219
           T    + K E D E  SE E     D ++  +    QEK    +     TS  AKG    
Sbjct: 533 TPSAQVGKWEEDSESSSE-ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591

Query: 220 EGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSE 279
            GP   +V + KP            +  ++  EE  +    E+    + + + KP  +  
Sbjct: 592 AGPVAVQVKAEKP------------MDNSESSEESSDSADSEEAPAAMTAAQAKPA-LKI 638

Query: 280 EQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVP 339
            Q     +K  T    +       V PV VG   P  K  T+ + AG +    + G    
Sbjct: 639 PQTKACPKKTNTTASAK-------VAPVRVGTQAPR-KAGTATSPAGSS--PAVAGGTQR 688

Query: 340 PAEESPEVTTEAAEAS----AVEAGSEVSEKPGQEA-----PVLPKDGAVNGPSVVGDQT 390
           PAE+S       +E      AV  G   S   G +      PV    G    P + G   
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748

Query: 391 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 450
           P   Q   E+  +++      +   A   P+Q   K SV++++A  +    +        
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 451 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE 510
           S   KV  AA +  Q    ++K       +         +      +V      Q   EE
Sbjct: 807 SAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEE 866

Query: 511 EIGNLELAWDMLDLAKIIFK-RQETKEAQLYAAQAHLK 547
           + G+ E   D  + A+ + + +   K  Q+ AA A  K
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 102/496 (20%), Positives = 174/496 (35%), Gaps = 92/496 (18%)

Query: 12  AAELVSADKIEDVPAPSTSADKVESLDVDS-EAKKLLGLGQKHLVMGDIPAAVNAFQEAA 70
           AA      ++ D  + S S+++ E  + ++ +A   L      ++  D+P+++   +E A
Sbjct: 69  AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM---KEKA 125

Query: 71  SLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVE 130
               +K G+T N         GK++  L                     G+     +   
Sbjct: 126 KAETEKAGKTGNSMPHPAT--GKTVANLL-------------------SGKSPRKSAEPS 164

Query: 131 NNDNIDEEAREELREQVYDAMGEK------EEAKKTEDKSLAKPETDKEQDSEMEKGGRE 184
            N  +  E  EE     + A  +       +    +ED S +  ETD E    ++    +
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224

Query: 185 DMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEE--- 241
              +S + E P  K       + + + + KGGA P         + KPE+E   +EE   
Sbjct: 225 ASSVS-TKESPARKAAPAPGKVGDVTPQVKGGALPPAKR-----AKKPEEESESSEEGSE 278

Query: 242 --EKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQP---VVTLEKQGTAVEVE 296
             E++ +GT  Q +  EK  Q +        +  P + +   P      +  Q  A + E
Sbjct: 279 SEEEAPAGTRSQVKASEKILQVRAASA--PAKGTPGKGATPAPPGKAGAVASQTKAGKPE 336

Query: 297 AESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356
            +S   + +  D   + P  K +     +GK      VG    PA+ESP      A    
Sbjct: 337 EDSESSSEESSDSEEETPAAKALLQAKASGKT---SQVGAASAPAKESPRKGAAPAP--- 390

Query: 357 VEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416
                     PG+  P + K  A  G      Q+  E   S E        SG   +VRA
Sbjct: 391 ----------PGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 417 KLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEE 476
              P++E  +                  +GA    P      AA         Q++ G++
Sbjct: 439 ASAPAKESPR------------------KGAAPAPPRKTGPAAA---------QVQVGKQ 471

Query: 477 TEGSEEDDKENDKTEE 492
            E S    +E+D   E
Sbjct: 472 EEDSRSSSEESDSDRE 487



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 90/447 (20%), Positives = 159/447 (35%), Gaps = 57/447 (12%)

Query: 366 KPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEET 425
           K  ++A +  K   V+ P    + +  E +   E    T   +     V    +PS  + 
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 426 KLSVEESEAAGDG-------VDTKVAQGATEKSPEDKVQIAAN----EETQE-------- 466
           K   E  +A   G           VA   + KSP    + +AN     ET+E        
Sbjct: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183

Query: 467 ---REEQMKEGEETEGSEEDDKENDKT--EEMPNDSVLENKSLQENEEEEIGNLELAWDM 521
              +   +  G+    SE+    +D+T  E  P+    + K+   + +E           
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP- 242

Query: 522 LDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDR 581
               K+     + K   L  A+   K  E S  SE   ++ EE  +    Q   ++A ++
Sbjct: 243 ---GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEK 296

Query: 582 LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEE 641
           +L +       A G   +               + +     E  + +   S++ ++E   
Sbjct: 297 IL-QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355

Query: 642 LKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTP---GGGGSSVSMIASRK 698
            K LL         AK S ++  V   A  A   ES   G  P   G  G +V+   + K
Sbjct: 356 AKALL--------QAKASGKTSQVG--AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK 405

Query: 699 PTDGASSSNCVTDISHLVRKKRKPEEESPR--------KDDAKK--AKQEPEVNGGSGDA 748
             + + SS+  +D       + KP  ++P+        K+  +K  A   P   G +   
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 749 VPSG--NEVSENMEEEAENQAESRAAV 773
           V  G   E S +  EE+++  E+ AA+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAM 492



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 48/189 (25%), Positives = 74/189 (39%), Gaps = 39/189 (20%)

Query: 624 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFT 683
           QVK      A+  K+ EE  E   E  E  E+A    RS   A   +      S+ +  T
Sbjct: 251 QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310

Query: 684 PGGG---------GSSVSMIASRKPTDGASSSNCVTDISH--------LVRKKRK----- 721
           PG G         G+  S   + KP + + SS+  +  S         L++ K       
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370

Query: 722 ------PEEESPRKDDAKKAKQEPEVNGGSGDAVPSG-----NEVSENMEEEAENQAESR 770
                 P +ESPRK  A      P   G +G AV         E S++  EE++++ E+ 
Sbjct: 371 VGAASAPAKESPRKGAA------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 771 AAVEGTVEA 779
           A  + + +A
Sbjct: 425 AQAKPSGKA 433


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 121/607 (19%), Positives = 249/607 (41%), Gaps = 90/607 (14%)

Query: 124  EDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGR 183
            E+++ ++     +EEAR+ L +QV     +  + KK  D  L   E+ +E   ++ K   
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK--- 1399

Query: 184  EDMDISKSAEEPQEKVDLTLDWLTETS---EEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240
               D    ++  +EK  L  D L +T    ++       +  ++ +V S   +++    +
Sbjct: 1400 ---DAEALSQRLEEKA-LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 241  ---EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEA 297
               EEKS+S    +E  R +    ++    +S+    +E  E +     E+Q   +  + 
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE--EFERQNKQLRADM 1513

Query: 298  ESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAV 357
            E L  +    DVG +         E E  K  LEQ V +E+    E  E   +A E + +
Sbjct: 1514 EDLMSSKD--DVGKN-------VHELEKSKRALEQQV-EEMRTQLEELEDELQATEDAKL 1563

Query: 358  EAGSEVSEKPGQ-EAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRA 416
                 +     Q E  +  +D          +Q   + +  I+++ E +     E K RA
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRD----------EQNEEKKRLLIKQVRELEAELEDERKQRA 1613

Query: 417  KLVPSQEETKLSVEESEA-------AGDGV---------DTKVAQGATEKSPEDKVQIAA 460
              V S+++ ++ +++ EA       A D V           K  Q   E++   + +I A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 461  NEETQEREEQMKEGEETEGSEE-----------DDKENDKTEEMPNDS-----VLENK-- 502
              +  E++ +  E E  +  EE           + + ++  +E+ N +     +L+ K  
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 503  ------SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESE 556
                   L+E  EEE  N+EL  D      +   + +T  A+L A ++       + +S+
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTL---QVDTLNAELAAERS------AAQKSD 1784

Query: 557  NYVQAVEEFQSCLNLQEQYLEAHDR-----LLAETHYQLGLAYGYNSQYDEAVAQFSKSI 611
            N  Q +E     L  + Q LE   +      ++    ++G       Q  +  A  +K +
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844

Query: 612  EVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALK 671
               E ++  +  QV++    + +YK+++E+    + +++ ++E+A+E     N +   L+
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904

Query: 672  ATLVESS 678
              L +++
Sbjct: 1905 RELDDAT 1911



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 144/741 (19%), Positives = 291/741 (39%), Gaps = 95/741 (12%)

Query: 93   KSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREE---LREQVYD 149
            K LL++ R E  +     E + V+E++   T+ E  +E  +   ++  EE   L EQ+  
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQ---TKVEGELEEMERKHQQLLEEKNILAEQLQA 898

Query: 150  AMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTET 209
                  EA++   +  AK +  +E   ++E    E+ + ++  +  ++K+   +  L E 
Sbjct: 899  ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958

Query: 210  SEEAKGGAAPEGPNE--AEVTSGKPEQEVPDAEEEKS--VSGTDVQE----ECREKGGQE 261
             +E +G        +  AE    K E+E+   E++ S  +    + E    EC  +  +E
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 262  ------------KQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDV 309
                        KQ  +I  +EE+ K+  EE+    LEK    ++ E   L   +  +  
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076

Query: 310  GGDEPEEKVVTSENEAGKA----------------VLEQLVGQ--EVPPAEESPEVTTEA 351
              DE + ++   E E   A                V+ +L  Q  E+    ES + +   
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136

Query: 352  AEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLE 411
            AE    +   E+     +    L    A        +Q   E + ++E   ETK+     
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE--ETKNHEAQI 1194

Query: 412  EKVRAKLVPSQEETKLSVEES-------EAAGDGVDTKVAQGATEKSPEDKVQIAANEET 464
            + +R +   + EE    +E++       E    G++T   + A E     +V+  +  + 
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254

Query: 465  QEREEQMKE--GEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDML 522
            ++ + Q++E   + +EG     +  +K  ++ N+  L+N S    E E+ G ++ A D  
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE--LDNVSTLLEEAEKKG-IKFAKDAA 1311

Query: 523  DLAKIIFKRQET-KEAQLYAAQAHLKLGEVSVESENYV-QAVEEFQSCLNLQEQYLEAHD 580
             L   +   QE  +E          ++ ++  E  +   Q  EE ++  NL++Q L    
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371

Query: 581  RLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIE 640
            +L A+T  ++    G     +EA  +  K  E +  R+        + E +    ++E++
Sbjct: 1372 QL-ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 641  ELKELLPEIREKIEDAKESQRSGN---VAELALKATLVESSTSGFTPGGGGSSVSMIASR 697
            +L   L   R+   + ++ Q+  +     E ++ A   E                    R
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE-----------------RDR 1473

Query: 698  KPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSE 757
               +          ++  + +  + +EE  R++   +A  E        D + S ++V +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME--------DLMSSKDDVGK 1525

Query: 758  NMEEEAENQAESRAAVEGTVE 778
            N+ E      +S+ A+E  VE
Sbjct: 1526 NVHE----LEKSKRALEQQVE 1542


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 86/441 (19%), Positives = 177/441 (40%), Gaps = 42/441 (9%)

Query: 241 EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL 300
           EE      ++QEE +    + ++ E+ + I+E  +++  ++  + L ++G   E E +  
Sbjct: 7   EELKEKNAELQEELQLV--ETEKSEIQLHIKELKRKLETDK--IPLPQEGQVREQEGQVR 62

Query: 301 DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG 360
           +   +  +  G   E++    E E       Q+  QE    E+  +V  +  E    E  
Sbjct: 63  EQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQ--EGQVREQE 114

Query: 361 SEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQT-SIERLTETKDGSGLEEKVR 415
            +V E+ GQ    E  V  ++G V      G     E Q    E     ++G   E++ +
Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVREQEGQVREQEGQ 172

Query: 416 AKLVPSQ-EETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEG 474
            +    Q  E +  V E E      + ++ +   +   +++      E+  E+EEQM++ 
Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232

Query: 475 EETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET 534
           EE  G +E+  +  + +    +  +  +  Q  E+EE         M +  + + K++E 
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE--------QMREQEEQMLKQKEQ 284

Query: 535 KEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLG--- 591
            E +    +   ++ E   +     + + E +  +  QE+ +   +  + E   Q+    
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344

Query: 592 -LAYGYNSQYDEAVAQFSKSIEVI----------ENRMAVLNEQVKEAEGSSAEYKKEIE 640
              +    Q  E   Q  K  E +          E +M    EQ+++ E    E K+++ 
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404

Query: 641 ELKELLPEIREKIEDAKESQR 661
           E KE + E  E++ + KE  R
Sbjct: 405 EQKEQMREQEEQMGEQKEQMR 425



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 80/421 (19%), Positives = 175/421 (41%), Gaps = 38/421 (9%)

Query: 222 PNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQ 281
           P E +V     EQE    E+E  V   + Q   +E   +E++G+V     E+  +V E++
Sbjct: 49  PQEGQVR----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQE 100

Query: 282 PVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPA 341
             V  E++G   E E +  +   +  +  G   E++    E E       Q+  QE    
Sbjct: 101 GQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG------QVREQEGQVR 153

Query: 342 EESPEVTTEAAEASAVEAGSEVSEKPGQ----EAPVLPKDGAVNGPSVVGDQTPIEPQTS 397
           E+  +V  +  E    E   +V E+ GQ    E  V  ++G +        +   +    
Sbjct: 154 EQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211

Query: 398 IERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQ 457
            E++ + ++  G +E+   K      E +  V++ E      + ++ +   +   +++  
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271

Query: 458 IAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNL-E 516
               E+  +++EQ ++ E+T   EE  +E ++      + + E +     +EE++G   E
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331

Query: 517 LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL 576
             W+  +      +  E KE Q++  +   ++GE   + +   + V + +  +  QE+ +
Sbjct: 332 QMWEQKE------QMWEQKE-QMWKQEE--QMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382

Query: 577 EAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYK 636
              +  + +   Q+G       +  E + +  + +   E +M    EQ+++ E    E K
Sbjct: 383 RKQEEQMRKQEEQMG-------EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435

Query: 637 K 637
           +
Sbjct: 436 E 436



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 81/403 (20%), Positives = 168/403 (41%), Gaps = 28/403 (6%)

Query: 115 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 174
           V E+EG+  E E  V   +    E   ++REQ      ++ + ++ E +   +    +EQ
Sbjct: 54  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 113

Query: 175 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 234
           + ++ +   +  +      E + +V            E +G    +     E      EQ
Sbjct: 114 EGQVREQEGQVREQEGQVREQEGQV-----------REQEGQVREQEGQVREQEGQVREQ 162

Query: 235 EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVE 294
           E    E+E  V   + + + RE+ GQ ++ E  +  +E      EEQ     E+     E
Sbjct: 163 EGQVREQEGQV--REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220

Query: 295 VEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEA 354
              E  +   K  +  G E EE+V   E +  K   EQ+  QE    E+  ++  +  + 
Sbjct: 221 QMGEQEEQMRKQEEQMG-EQEEQVQKQEEQVQKQE-EQMRKQEEQMREQEEQMREQEEQM 278

Query: 355 SAVEAGSEVSEKPG-QEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-LEE 412
              +  +E  E+ G QE  +  ++  +        +   + +   E++ E ++  G  EE
Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMR-------EQEEQMREQEEQMREQEEQMGKQEE 331

Query: 413 KVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK 472
           ++  +     E+ +   ++ E  G+  +    Q    +  E++++    E+ +++EEQM+
Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR-KQEEQMRKQEEQMR 390

Query: 473 EGEETEGSEEDDKENDKTEEM--PNDSVLENKSLQENEEEEIG 513
           + EE  G E+ ++  ++ E+M    + + E K     +EE +G
Sbjct: 391 KQEEQMG-EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 67/371 (18%), Positives = 154/371 (41%), Gaps = 25/371 (6%)

Query: 115 VEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQ 174
           V E+EG+  E E  V   +    E   ++REQ      ++ + ++ E +   +    +EQ
Sbjct: 89  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 148

Query: 175 DSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQ 234
           + ++ +   +  +      E + +V      + E   + +      G  E ++  G+ E+
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQM--GEQEE 206

Query: 235 EVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQPVVTLEKQGTAV 293
           ++ + EE+       + E+  +   QE+Q GE    ++++ ++V +++    + KQ   +
Sbjct: 207 QMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE--QMRKQEEQM 264

Query: 294 EVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE 353
             + E +    + +    ++ E++  T E E      E+ + ++     E  E   E  E
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEE 324

Query: 354 ASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEK 413
               +      +K   E     K+        +G+Q   + Q   E++ +       EE+
Sbjct: 325 QMGKQEEQMWEQK---EQMWEQKEQMWKQEEQMGEQEE-QMQKQEEQVRKQ------EEQ 374

Query: 414 VRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQ-EREEQMK 472
           +R +    +++ +   ++ E  G+           E+  E K Q+   EE   E++EQM+
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGE---------QKEQMGEQKEQMREQEEQMGEQKEQMR 425

Query: 473 EGEETEGSEED 483
           + EE  G +++
Sbjct: 426 KQEEHMGEQKE 436



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/172 (20%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPET 170
           E +  +EE+  + E++ L +      EE   E  EQ+ +   ++E+ ++ E++   + E 
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE---QEEQMREQEEQMREQEEQ 318

Query: 171 DKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSG 230
            +EQ+ +M K   +  +  +   E +E++     W     +E + G   E   + E    
Sbjct: 319 MREQEEQMGKQEEQMWEQKEQMWEQKEQM-----W----KQEEQMGEQEEQMQKQEEQVR 369

Query: 231 KPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQ-GEVIVSIEEKPKEVSEEQ 281
           K E+++   EE+       ++++  + G Q++Q GE    + E+ +++ E++
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)

Query: 96   LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155
            LE    + G     L+ +    EE E  + ++         +E  E LR QV D    K 
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511

Query: 156  EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214
            +A+  E  S  K E +  ++ +      E++ + ++ AE    + ++      + + E  
Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 215  GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274
              +A         +  +   ++  + +E+ V+   ++EE   +  Q+ + E   + EE  
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628

Query: 275  KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331
            +E+   Q       +   + ++AE +           ++ +E+        GKA  +   
Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 332  --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386
              +L  QE+    +  E T +   AAE   +   +E  +   Q   +  +   +   +  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 387  GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432
              Q   E +  + ++    +   L  K RA     +EE++ + E+S              
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 433  --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483
              EAA      + A+   + + ED  +  A  E    E+    GE T          +E 
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 484  DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531
            + EN++   +  D   + + L+E         EE +  L  A D        L +   ++
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 532  QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577
            +   E ++ A            A+  L+LG +   +E+ +++ E  E ++    Q    E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979

Query: 578  AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637
               R  AE   Q  LA       +EA  Q   ++E +E     L  +V+EA       ++
Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030

Query: 638  EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695
            E     +L  E  +K   A+E   +  V   E  L+ TL +  +      G        A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085

Query: 696  SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755
            +R+  + A  +         V+ +R+  +   + ++A++ KQ  E       A       
Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134

Query: 756  SENMEEEAENQAESRAAVE 774
            +E + +EAE +A  RA  E
Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)

Query: 119  EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171
            + E    + LVE+      +  EE+      A  EK  A K E        +S A+    
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 172  KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229
             ++ +E+E   +  +  +  +   E +E+V  +L    E + + K         E E   
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015

Query: 230  GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287
             K E+   + +  E++S     + +E  +K  Q ++     ++++K +E+ +     TL+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070

Query: 288  KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346
            ++ + ++     L    +      +E EE  V +E EA ++  +    + +   AEE  +
Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 347  VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399
               +A   AE    EA  E + +   E   L +    D  +       +QT  +     +
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 400  RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459
             LT  +    LEE    K +  +E  +L  E +EAA      +    +     E+  ++ 
Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244

Query: 460  ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515
            A  E + R   +++ + T+    EE +K     EE    SV   E   L++  EE++   
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 516  E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572
              LA  ML       K Q  +EA    A+A L  +  E++ E    +Q  +E Q    L 
Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358

Query: 573  EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632
            E+       L AE   QL               + S   E ++ R+A ++     AE  +
Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 633  AEYKKEIEELKELL 646
              ++K+ EE+ E L
Sbjct: 2404 QRFRKQAEEIGEKL 2417



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)

Query: 138  EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197
            +A  EL +Q  +   E+    + + + +A+   ++ Q  +          +  SAE   E
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383

Query: 198  KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257
            ++ L +  ++     A+  A        E+       E+   E+   V   ++Q +  + 
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 258  GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317
               E+  E I  +E + +++ +E  ++ L+ +     V+ E L    + +       ++ 
Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501

Query: 318  VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375
            ++  E   E  KA LEQL   EV  A++  E      +    E    V+           
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 376  KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430
             +  V        Q   + +   E L E           LEE+ RA L  S+E T   V 
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 431  ESEAAGDGVDTKVAQGATEKSPE 453
             ++   +G D  +   A E  PE
Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)

Query: 453  EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
            ++++Q     ++Q   EQ+++  E    EE ++  +K EE    +     ++++ E + +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287

Query: 513  GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568
                                 T +AQL    +  K  +V   SE+    YV     +   
Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326

Query: 569  LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626
              L  QY++     L     +  LA    ++  E +A+   ++E  + ++A  + Q K  
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385

Query: 627  --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661
                                EA   + + K+ I EEL++L      EI+ K   A+ ++R
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 662  SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721
            S    E  ++   ++   +    GG    +  + +R     A       +   L   +R+
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502

Query: 722  PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768
             ++ES RK  A+     + K E E       A+ +  E+    EE        E E   +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 769  SRAAVEGTVEAGATVE 784
             + A+E T +  A  E
Sbjct: 1563 VQVALE-TAQRSAEAE 1577


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)

Query: 96   LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155
            LE    + G     L+ +    EE E  + ++         +E  E LR QV D    K 
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1515

Query: 156  EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214
            +A+  E  S  K E +  ++ +      E++ + ++ AE    + ++      + + E  
Sbjct: 1516 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574

Query: 215  GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274
              +A         +  +   ++  + +E+ V+   ++EE   +  Q+ + E   + EE  
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1632

Query: 275  KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331
            +E+   Q       +   + ++AE +           ++ +E+        GKA  +   
Sbjct: 1633 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689

Query: 332  --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386
              +L  QE+    +  E T +   AAE   +   +E  +   Q   +  +   +   +  
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749

Query: 387  GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432
              Q   E +  + ++    +   L  K RA     +EE++ + E+S              
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1803

Query: 433  --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483
              EAA      + A+   + + ED  +  A  E    E+    GE T          +E 
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863

Query: 484  DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531
            + EN++   +  D   + + L+E         EE +  L  A D        L +   ++
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923

Query: 532  QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577
            +   E ++ A            A+  L+LG +   +E+ +++ E  E ++    Q    E
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983

Query: 578  AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637
               R  AE   Q  LA       +EA  Q   ++E +E     L  +V+EA       ++
Sbjct: 1984 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2034

Query: 638  EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695
            E     +L  E  +K   A+E   +  V   E  L+ TL +  +      G        A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2089

Query: 696  SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755
            +R+  + A  +         V+ +R+  +   + ++A++ KQ  E       A       
Sbjct: 2090 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2138

Query: 756  SENMEEEAENQAESRAAVE 774
            +E + +EAE +A  RA  E
Sbjct: 2139 AEKLRKEAEQEAARRAQAE 2157



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)

Query: 119  EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171
            + E    + LVE+      +  EE+      A  EK  A K E        +S A+    
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 172  KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229
             ++ +E+E   +  +  +  +   E +E+V  +L    E + + K         E E   
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2019

Query: 230  GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287
             K E+   + +  E++S     + +E  +K  Q ++     ++++K +E+ +     TL+
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2074

Query: 288  KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346
            ++ + ++     L    +      +E EE  V +E EA ++  +    + +   AEE  +
Sbjct: 2075 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130

Query: 347  VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399
               +A   AE    EA  E + +   E   L +    D  +       +QT  +     +
Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190

Query: 400  RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459
             LT  +    LEE    K +  +E  +L  E +EAA      +    +     E+  ++ 
Sbjct: 2191 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248

Query: 460  ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515
            A  E + R   +++ + T+    EE +K     EE    SV   E   L++  EE++   
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308

Query: 516  E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572
              LA  ML       K Q  +EA    A+A L  +  E++ E    +Q  +E Q    L 
Sbjct: 2309 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2362

Query: 573  EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632
            E+       L AE   QL               + S   E ++ R+A ++     AE  +
Sbjct: 2363 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2407

Query: 633  AEYKKEIEELKELL 646
              ++K+ EE+ E L
Sbjct: 2408 QRFRKQAEEIGEKL 2421



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)

Query: 138  EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197
            +A  EL +Q  +   E+    + + + +A+   ++ Q  +          +  SAE   E
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2387

Query: 198  KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257
            ++ L +  ++     A+  A        E+       E+   E+   V   ++Q +  + 
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447

Query: 258  GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317
               E+  E I  +E + +++ +E  ++ L+ +     V+ E L    + +       ++ 
Sbjct: 2448 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2505

Query: 318  VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375
            ++  E   E  KA LEQL   EV  A++  E      +    E    V+           
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565

Query: 376  KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430
             +  V        Q   + +   E L E           LEE+ RA L  S+E T   V 
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625

Query: 431  ESEAAGDGVDTKVAQGATEKSPE 453
             ++   +G D  +   A E  PE
Sbjct: 2626 ATKTLPNGRDA-LDGPAAEAEPE 2647



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)

Query: 453  EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
            ++++Q     ++Q   EQ+++  E    EE ++  +K EE    +     ++++ E + +
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1291

Query: 513  GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568
                                 T +AQL    +  K  +V   SE+    YV     +   
Sbjct: 1292 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330

Query: 569  LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626
              L  QY++     L     +  LA    ++  E +A+   ++E  + ++A  + Q K  
Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1389

Query: 627  --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661
                                EA   + + K+ I EEL++L      EI+ K   A+ ++R
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449

Query: 662  SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721
            S    E  ++   ++   +    GG    +  + +R     A       +   L   +R+
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1506

Query: 722  PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768
             ++ES RK  A+     + K E E       A+ +  E+    EE        E E   +
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566

Query: 769  SRAAVEGTVEAGATVE 784
             + A+E T +  A  E
Sbjct: 1567 VQVALE-TAQRSAEAE 1581


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 141/739 (19%), Positives = 275/739 (37%), Gaps = 106/739 (14%)

Query: 96   LELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKE 155
            LE    + G     L+ +    EE E  + ++         +E  E LR QV D    K 
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQA---------QEEAERLRRQVQDESQRKR 1511

Query: 156  EAKKTEDKSLAKPETDKEQDSEMEKGGREDMDI-SKSAEEPQEKVDLTLDWLTETSEEAK 214
            +A+  E  S  K E +  ++ +      E++ + ++ AE    + ++      + + E  
Sbjct: 1512 QAE-VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 215  GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKP 274
              +A         +  +   ++  + +E+ V+   ++EE   +  Q+ + E   + EE  
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER--AREEAE 1628

Query: 275  KEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLE--- 331
            +E+   Q       +   + ++AE +           ++ +E+        GKA  +   
Sbjct: 1629 RELERWQ---LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 332  --QLVGQEVPPAEESPEVTTE---AAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVV 386
              +L  QE+    +  E T +   AAE   +   +E  +   Q   +  +   +   +  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 387  GDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEES-------------- 432
              Q   E +  + ++    +   L  K RA     +EE++ + E+S              
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVL-LASKARA-----EEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 433  --EAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETE-------GSEED 483
              EAA      + A+   + + ED  +  A  E    E+    GE T          +E 
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 484  DKENDKTEEMPNDSVLENKSLQENE-------EEEIGNLELAWD-----MLDLAKIIFKR 531
            + EN++   +  D   + + L+E         EE +  L  A D        L +   ++
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 532  QETKEAQLYA------------AQAHLKLGEVSVESENYVQAVE--EFQSCLNLQEQYLE 577
            +   E ++ A            A+  L+LG +   +E+ +++ E  E ++    Q    E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979

Query: 578  AHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKK 637
               R  AE   Q  LA       +EA  Q   ++E +E     L  +V+EA       ++
Sbjct: 1980 ERRRREAEERVQKSLA-----AEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQ 2030

Query: 638  EIEELKELLPEIREKIEDAKESQRSGNV--AELALKATLVESSTSGFTPGGGGSSVSMIA 695
            E     +L  E  +K   A+E   +  V   E  L+ TL +  +      G        A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-----A 2085

Query: 696  SRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEV 755
            +R+  + A  +         V+ +R+  +   + ++A++ KQ  E       A       
Sbjct: 2086 ARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQAQAA 2134

Query: 756  SENMEEEAENQAESRAAVE 774
            +E + +EAE +A  RA  E
Sbjct: 2135 AEKLRKEAEQEAARRAQAE 2153



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 119/554 (21%), Positives = 219/554 (39%), Gaps = 65/554 (11%)

Query: 119  EGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTE-------DKSLAKPETD 171
            + E    + LVE+      +  EE+      A  EK  A K E        +S A+    
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 172  KEQDSEMEKGGREDM--DISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTS 229
             ++ +E+E   +  +  +  +   E +E+V  +L    E + + K         E E   
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-----EEVERLK 2015

Query: 230  GKPEQ--EVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLE 287
             K E+   + +  E++S     + +E  +K  Q ++     ++++K +E+ +     TL+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ-----TLQ 2070

Query: 288  KQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPP-AEESPE 346
            ++ + ++     L    +      +E EE  V +E EA ++  +    + +   AEE  +
Sbjct: 2071 QEQSVLD----QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 347  VTTEA---AEASAVEAGSEVSEKPGQEAPVLPK----DGAVNGPSVVGDQTPIEPQTSIE 399
               +A   AE    EA  E + +   E   L +    D  +       +QT  +     +
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 400  RLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIA 459
             LT  +    LEE    K +  +E  +L  E +EAA      +    +     E+  ++ 
Sbjct: 2187 ELTTLR--LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244

Query: 460  ANEETQEREEQMKEGEETEG--SEEDDKENDKTEEMPNDSVL--ENKSLQENEEEEIGNL 515
            A  E + R   +++ + T+    EE +K     EE    SV   E   L++  EE++   
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 516  E-LAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQ 572
              LA  ML       K Q  +EA    A+A L  +  E++ E    +Q  +E Q    L 
Sbjct: 2305 RALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE-QMAQQLA 2358

Query: 573  EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 632
            E+       L AE   QL               + S   E ++ R+A ++     AE  +
Sbjct: 2359 EETQGFQRTLEAERQRQL---------------EMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 633  AEYKKEIEELKELL 646
              ++K+ EE+ E L
Sbjct: 2404 QRFRKQAEEIGEKL 2417



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 63/323 (19%), Positives = 120/323 (37%), Gaps = 12/323 (3%)

Query: 138  EAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQE 197
            +A  EL +Q  +   E+    + + + +A+   ++ Q  +          +  SAE   E
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA--E 2383

Query: 198  KVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREK 257
            ++ L +  ++     A+  A        E+       E+   E+   V   ++Q +  + 
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 258  GGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317
               E+  E I  +E + +++ +E  ++ L+ +     V+ E L    + +       ++ 
Sbjct: 2444 DA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQT-VQQEQLLQETQALQQSFLSEKDS 2501

Query: 318  VVTSEN--EAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLP 375
            ++  E   E  KA LEQL   EV  A++  E      +    E    V+           
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 376  KDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSG-----LEEKVRAKLVPSQEETKLSVE 430
             +  V        Q   + +   E L E           LEE+ RA L  S+E T   V 
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 431  ESEAAGDGVDTKVAQGATEKSPE 453
             ++   +G D  +   A E  PE
Sbjct: 2622 ATKTLPNGRDA-LDGPAAEAEPE 2643



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 73/376 (19%), Positives = 141/376 (37%), Gaps = 72/376 (19%)

Query: 453  EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 512
            ++++Q     ++Q   EQ+++  E    EE ++  +K EE    +     ++++ E + +
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQ--EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV 1287

Query: 513  GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN----YVQAVEEFQSC 568
                                 T +AQL    +  K  +V   SE+    YV     +   
Sbjct: 1288 ---------------------TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326

Query: 569  LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK-- 626
              L  QY++     L     +  LA    ++  E +A+   ++E  + ++A  + Q K  
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQ 1385

Query: 627  --------------------EAEGSSAEYKKEI-EELKELL----PEIREKIEDAKESQR 661
                                EA   + + K+ I EEL++L      EI+ K   A+ ++R
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 662  SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRK 721
            S    E  ++   ++   +    GG    +  + +R     A       +   L   +R+
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL---RRQ 1502

Query: 722  PEEESPRKDDAK-----KAKQEPEVNGGSGDAVPSGNEVSENMEE--------EAENQAE 768
             ++ES RK  A+     + K E E       A+ +  E+    EE        E E   +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 769  SRAAVEGTVEAGATVE 784
             + A+E T +  A  E
Sbjct: 1563 VQVALE-TAQRSAEAE 1577


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.299    0.121    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,198,424
Number of Sequences: 37866
Number of extensions: 1585538
Number of successful extensions: 23899
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 1388
Number of HSP's that attempted gapping in prelim test: 9241
Number of HSP's gapped (non-prelim): 9254
length of query: 788
length of database: 18,247,518
effective HSP length: 110
effective length of query: 678
effective length of database: 14,082,258
effective search space: 9547770924
effective search space used: 9547770924
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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