Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 25952122
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
(519 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 1036 0.0
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 75 1e-13
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 75 1e-13
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 75 1e-13
gi|224809432 transmembrane and tetratricopeptide repeat containi... 73 7e-13
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 70 5e-12
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 70 5e-12
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 70 5e-12
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 70 5e-12
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 70 5e-12
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 63 6e-10
gi|83415184 transmembrane and tetratricopeptide repeat containin... 62 1e-09
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 59 1e-08
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 59 1e-08
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 58 2e-08
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 58 2e-08
gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens] 58 2e-08
gi|118766328 transmembrane and tetratricopeptide repeat containi... 55 2e-07
gi|118766330 transmembrane and tetratricopeptide repeat containi... 55 2e-07
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 54 3e-07
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens] 53 6e-07
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 53 8e-07
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 52 1e-06
gi|22749211 transmembrane and tetratricopeptide repeat containin... 52 1e-06
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 50 4e-06
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 50 4e-06
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 49 1e-05
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 49 1e-05
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 49 1e-05
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 49 1e-05
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 1036 bits (2678), Expect = 0.0
Identities = 519/519 (100%), Positives = 519/519 (100%)
Query: 1 MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQ 60
MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQ
Sbjct: 1 MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQ 60
Query: 61 ETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAA 120
ETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAA
Sbjct: 61 ETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAA 120
Query: 121 IEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLL 180
IEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLL
Sbjct: 121 IEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLL 180
Query: 181 EGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAIL 240
EGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAIL
Sbjct: 181 EGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAIL 240
Query: 241 AAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLA 300
AAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLA
Sbjct: 241 AAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLA 300
Query: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA 360
PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA
Sbjct: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA 360
Query: 361 YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEM 420
YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEM
Sbjct: 361 YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEM 420
Query: 421 AQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRT 480
AQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRT
Sbjct: 421 AQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRT 480
Query: 481 LPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK 519
LPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK
Sbjct: 481 LPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK 519
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 75.5 bits (184), Expect = 1e-13
Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 3/270 (1%)
Query: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
KDW +G CY L + +A+ Q +AL T++ L K+++ A+ ++K
Sbjct: 223 KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFK 282
Query: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
+ ++ P LL + +Y ++ A E+ L D T+ +AI GS
Sbjct: 283 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 342
Query: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK---ILYN 309
++AL YR + + L+NN+G+C F ++Y ++ +RA LA + + + YN
Sbjct: 343 EIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYN 402
Query: 310 LGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDK 369
LG V + + A A+ E Y LAV +E A+ A L
Sbjct: 403 LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 462
Query: 370 CNPLVNLNYAVLLYNQGEKKNALAQYQEME 399
+ N+A + G+ + + Q+ E
Sbjct: 463 HMYEPHFNFATISDKIGDLQRSYVAAQKSE 492
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/246 (17%), Positives = 99/246 (40%), Gaps = 9/246 (3%)
Query: 32 LEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQAL-----IFRLEGNIQES 86
L++Q + Y+ K Y + + QGL ++ V L I+ N+ +
Sbjct: 252 LKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSA 311
Query: 87 LELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI 146
E ++ + + + + F + + A+ Y ++ + ++ +NLG+C
Sbjct: 312 AEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCF 371
Query: 147 YLKQFNKAQDQLHNALNLNRHDL----TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
Y +Q++ AL+L ++ + LG + + GD + A + ++ A+ + +
Sbjct: 372 YAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHA 431
Query: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
E L +L ++ G ++A L A + P Y+ ++ GD + +
Sbjct: 432 EAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKS 491
Query: 263 ACAVPE 268
A P+
Sbjct: 492 EAAFPD 497
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 75.5 bits (184), Expect = 1e-13
Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 3/270 (1%)
Query: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
KDW +G CY L + +A+ Q +AL T++ L K+++ A+ ++K
Sbjct: 183 KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFK 242
Query: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
+ ++ P LL + +Y ++ A E+ L D T+ +AI GS
Sbjct: 243 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 302
Query: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK---ILYN 309
++AL YR + + L+NN+G+C F ++Y ++ +RA LA + + + YN
Sbjct: 303 EIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYN 362
Query: 310 LGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDK 369
LG V + + A A+ E Y LAV +E A+ A L
Sbjct: 363 LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 422
Query: 370 CNPLVNLNYAVLLYNQGEKKNALAQYQEME 399
+ N+A + G+ + + Q+ E
Sbjct: 423 HMYEPHFNFATISDKIGDLQRSYVAAQKSE 452
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/246 (17%), Positives = 99/246 (40%), Gaps = 9/246 (3%)
Query: 32 LEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQAL-----IFRLEGNIQES 86
L++Q + Y+ K Y + + QGL ++ V L I+ N+ +
Sbjct: 212 LKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSA 271
Query: 87 LELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI 146
E ++ + + + + F + + A+ Y ++ + ++ +NLG+C
Sbjct: 272 AEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCF 331
Query: 147 YLKQFNKAQDQLHNALNLNRHDL----TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
Y +Q++ AL+L ++ + LG + + GD + A + ++ A+ + +
Sbjct: 332 YAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHA 391
Query: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
E L +L ++ G ++A L A + P Y+ ++ GD + +
Sbjct: 392 EAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKS 451
Query: 263 ACAVPE 268
A P+
Sbjct: 452 EAAFPD 457
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 75.5 bits (184), Expect = 1e-13
Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 3/270 (1%)
Query: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
KDW +G CY L + +A+ Q +AL T++ L K+++ A+ ++K
Sbjct: 213 KDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFK 272
Query: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
+ ++ P LL + +Y ++ A E+ L D T+ +AI GS
Sbjct: 273 QGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQP 332
Query: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK---ILYN 309
++AL YR + + L+NN+G+C F ++Y ++ +RA LA + + + YN
Sbjct: 333 EIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYN 392
Query: 310 LGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDK 369
LG V + + A A+ E Y LAV +E A+ A L
Sbjct: 393 LGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAP 452
Query: 370 CNPLVNLNYAVLLYNQGEKKNALAQYQEME 399
+ N+A + G+ + + Q+ E
Sbjct: 453 HMYEPHFNFATISDKIGDLQRSYVAAQKSE 482
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/246 (17%), Positives = 99/246 (40%), Gaps = 9/246 (3%)
Query: 32 LEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQAL-----IFRLEGNIQES 86
L++Q + Y+ K Y + + QGL ++ V L I+ N+ +
Sbjct: 242 LKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSA 301
Query: 87 LELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI 146
E ++ + + + + F + + A+ Y ++ + ++ +NLG+C
Sbjct: 302 AEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCF 361
Query: 147 YLKQFNKAQDQLHNALNLNRHDL----TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
Y +Q++ AL+L ++ + LG + + GD + A + ++ A+ + +
Sbjct: 362 YAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHA 421
Query: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
E L +L ++ G ++A L A + P Y+ ++ GD + +
Sbjct: 422 EAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKS 481
Query: 263 ACAVPE 268
A P+
Sbjct: 482 EAAFPD 487
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 72.8 bits (177), Expect = 7e-13
Identities = 95/431 (22%), Positives = 173/431 (40%), Gaps = 33/431 (7%)
Query: 80 EGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKL-------NQ 132
E N + +L+ F + P V R+ L + K A E Y A L +
Sbjct: 459 EKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKK 518
Query: 133 KDWEISHNLGVCYIYLKQFNKAQ-------DQLHNALNLNRHDL--TYIMLGKIHLLEGD 183
I+ N YI L +A DQL+ R D YI G++ L
Sbjct: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
Query: 184 LDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG 243
KA E Y KA+E N +L L +++++L +A ++ AL +P + A+ +
Sbjct: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
Query: 244 SMMQTHGDFDVALTKYRVVACAVPESPPLWN---NIGMCFFGKKKYVAAISCLKRANYLA 300
+MQ G+ + + + + E P N N+GM KK A +K+A L
Sbjct: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQ 698
Query: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQP-KMGELYMLLAVALTNLEDIENAKR 359
L+NL L++ + A L + + P + L + + + +DI AK+
Sbjct: 699 ADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKK 758
Query: 360 AYAEAVHLDKCNPLVNLNYAVLLYNQGE---------KKNALAQYQE-MEKKVSLLKDNS 409
+ + +D N N V+ + + + + ALA ++E +++ +++++D
Sbjct: 759 CFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKI 818
Query: 410 SLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALG 469
S S +E V + T+ VK+ + + + T K + + SN+ LG
Sbjct: 819 S---SSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLG 875
Query: 470 QAMSSAAAYRT 480
+ ++T
Sbjct: 876 KNGDEETPHKT 886
Score = 55.8 bits (133), Expect = 9e-08
Identities = 64/279 (22%), Positives = 110/279 (39%), Gaps = 41/279 (14%)
Query: 75 LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKD 134
LI E ++E+ +L++ + P L + K A E Y +A +L++ +
Sbjct: 537 LIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596
Query: 135 WEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLT----------------------- 170
++ +NL + +I LK+ N+A + AL LN +H L
Sbjct: 597 ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKR 656
Query: 171 --------------YIMLGKIHLLEGDLDKAIEVY-KKAVEFSPENTELLTTLGLLYLQL 215
Y LG + ++ D E++ KKA++ + L L LLY Q
Sbjct: 657 LLSYINEEPLDANGYFNLGML-AMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQT 715
Query: 216 GIYQKAFEHLGNALTYDPTNYKAILAAGS-MMQTHGDFDVALTKYRVVACAVPESPPLWN 274
KA L L Y P + K ++ G +M D A + + P + +
Sbjct: 716 AKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKH 775
Query: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLV 313
N+ + +F +K + A CL LAP + I +L +V
Sbjct: 776 NLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIV 814
Score = 32.0 bits (71), Expect = 1.4
Identities = 34/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%)
Query: 272 LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAI 331
LWNN+G +K + A+ +A ++ P D N+G + + + A A
Sbjct: 448 LWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAK 507
Query: 332 NFQPKM--GELY--------MLLAVALTNL-----EDIENAKRAYAEAVHLDKCNPLVNL 376
+ P++ G+ Y + + + L NL +E A + Y +A+ + +
Sbjct: 508 SLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYI 567
Query: 377 NYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQK 423
+ LL + A Y K + L ++N+ L ++ +V + K
Sbjct: 568 SRGELLLKMNKPLKAKEAYL---KALELDRNNADLWYNLAIVHIELK 611
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 70.1 bits (170), Expect = 5e-12
Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 19/310 (6%)
Query: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYI 172
LG++ A+E + +AA +++ + + H +C+ + +F +A + AL +N L Y+
Sbjct: 1283 LGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
Query: 173 MLGKIHLLEGDLDKAIEVYK---KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNAL 229
G ++ G + + K KA+ +P + + G G +QKA+ H A+
Sbjct: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
Query: 230 TYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC--FFGKKKYV 287
DP NY A + G+ A+ A + + N G+ F G K+
Sbjct: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA-AMKISTTAEFLTNRGVIHEFMGHKQN- 1460
Query: 288 AAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVA 347
A+ + A L P +N G ++ +Q++ A + S A+ F P+ + M A+
Sbjct: 1461 -AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT 1519
Query: 348 LTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK---KVSL 404
T L+ E AK +A + + C P +A + +N+ L QY+ E+ K
Sbjct: 1520 NTILKKYEEAKEDFANVI--ESC-PF----WAAVYFNRAHFYYCLKQYELAEEDLNKALS 1572
Query: 405 LKDNSSLEFD 414
LK N +L ++
Sbjct: 1573 LKPNDALVYN 1582
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/257 (22%), Positives = 107/257 (41%), Gaps = 13/257 (5%)
Query: 124 YNEAAKLNQKDWEISHNLGVCYIYLK-----------QFNKAQDQLHNALNLN-RHDLTY 171
++EA K QKD+ + ++ YI + +F KA + A++ + ++ L Y
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
+ L G+ A++ A++ S E LT G+++ +G Q A + +A+T
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471
Query: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAIS 291
+P A AG++ H F A + PE+ + N + KKY A
Sbjct: 1472 NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Query: 292 CLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL 351
PF + +N + ++QY A L+ A++ +P +Y A +
Sbjct: 1532 DFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591
Query: 352 EDIENAKRAYAEAVHLD 368
IE A Y +A+ L+
Sbjct: 1592 GLIEEAMADYNQALDLE 1608
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 7/169 (4%)
Query: 71 YVQALI-----FRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYN 125
Y++A I + +G Q++ F P++ + A +G + AA++ N
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 126 EAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDL 184
A K++ E N GV + ++ A +A+ LN ++ L Y G I+
Sbjct: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 185 DKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
+A + + KA++F PEN +L + L Y++A E N + P
Sbjct: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCP 1541
Score = 39.3 bits (90), Expect = 0.009
Identities = 74/374 (19%), Positives = 142/374 (37%), Gaps = 25/374 (6%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQ----------TCAV 95
K Y+ K I + + +GL E + QALI+ N +++E+ CA+
Sbjct: 1097 KYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL 1156
Query: 96 LSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI----YLKQF 151
L+ K+ ++ +L K A ++ + +NLG+CY+ +
Sbjct: 1157 LAKVQM-KAKRTKEAVEVLKKALDASSHSDKGPDATTISADCLYNLGLCYMEEGNLQMTY 1215
Query: 152 NKAQDQLHNALNLNRHD-LTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTL-- 208
A L A++++++ + + + +L A+ Y + T L T
Sbjct: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 209 -GLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKY----RVVA 263
GL+Y++LG Y A E A TN A +F+ A+ + ++
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
Query: 264 CAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASA 323
C + N+ M + + A +A ++ P K + G ++ A
Sbjct: 1336 CFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKA 1394
Query: 324 FHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLY 383
++ + AI+ PK Y AV + + A + A+ + + N V+
Sbjct: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT-NRGVIHE 1453
Query: 384 NQGEKKNALAQYQE 397
G K+NA+ YQ+
Sbjct: 1454 FMGHKQNAMKDYQD 1467
Score = 35.8 bits (81), Expect = 0.097
Identities = 84/419 (20%), Positives = 147/419 (35%), Gaps = 61/419 (14%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLK 105
K YE+ ++ E++ + +A + I+R G +Q ++ Q +L P +
Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYW 955
Query: 106 QVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN 165
K A++ N K N+ + E + Y K A A+
Sbjct: 956 HRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKST 1015
Query: 166 RHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEH 224
D Y G+++ + + AI+ + K + + P+ T+ L GL Y + + A E
Sbjct: 1016 PTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074
Query: 225 LGNALTYDPTNYKAILAAGSMMQTHGDFDVA-LTKYRVVAC--AVPESPPL--------- 272
L D N + A G + +D+A T Y++ + E P+
Sbjct: 1075 FTALLNIDHQNSQ---ARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFC 1131
Query: 273 --------------WNNIGMCF--------FGKKKYVAAISCLKRANYLAPFDWK----- 305
WN M K+ A+ LK+A + K
Sbjct: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDASSHSDKGPDAT 1191
Query: 306 -----ILYNLGLVHL----TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIEN 356
LYNLGL ++ Y A L+ AI+ + A+ T + +++
Sbjct: 1192 TISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251
Query: 357 AKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQY----QEMEKKVSLLKDNSSL 411
A Y + LD V LN N+G L QY ++ ++ + + N SL
Sbjct: 1252 ALTDYGIVLLLD-ATETVKLN---TFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 70.1 bits (170), Expect = 5e-12
Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 19/310 (6%)
Query: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYI 172
LG++ A+E + +AA +++ + + H +C+ + +F +A + AL +N L Y+
Sbjct: 1283 LGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
Query: 173 MLGKIHLLEGDLDKAIEVYK---KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNAL 229
G ++ G + + K KA+ +P + + G G +QKA+ H A+
Sbjct: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
Query: 230 TYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC--FFGKKKYV 287
DP NY A + G+ A+ A + + N G+ F G K+
Sbjct: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA-AMKISTTAEFLTNRGVIHEFMGHKQN- 1460
Query: 288 AAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVA 347
A+ + A L P +N G ++ +Q++ A + S A+ F P+ + M A+
Sbjct: 1461 -AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT 1519
Query: 348 LTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK---KVSL 404
T L+ E AK +A + + C P +A + +N+ L QY+ E+ K
Sbjct: 1520 NTILKKYEEAKEDFANVI--ESC-PF----WAAVYFNRAHFYYCLKQYELAEEDLNKALS 1572
Query: 405 LKDNSSLEFD 414
LK N +L ++
Sbjct: 1573 LKPNDALVYN 1582
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/257 (22%), Positives = 107/257 (41%), Gaps = 13/257 (5%)
Query: 124 YNEAAKLNQKDWEISHNLGVCYIYLK-----------QFNKAQDQLHNALNLN-RHDLTY 171
++EA K QKD+ + ++ YI + +F KA + A++ + ++ L Y
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
+ L G+ A++ A++ S E LT G+++ +G Q A + +A+T
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471
Query: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAIS 291
+P A AG++ H F A + PE+ + N + KKY A
Sbjct: 1472 NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Query: 292 CLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL 351
PF + +N + ++QY A L+ A++ +P +Y A +
Sbjct: 1532 DFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591
Query: 352 EDIENAKRAYAEAVHLD 368
IE A Y +A+ L+
Sbjct: 1592 GLIEEAMADYNQALDLE 1608
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 7/169 (4%)
Query: 71 YVQALI-----FRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYN 125
Y++A I + +G Q++ F P++ + A +G + AA++ N
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 126 EAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDL 184
A K++ E N GV + ++ A +A+ LN ++ L Y G I+
Sbjct: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 185 DKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
+A + + KA++F PEN +L + L Y++A E N + P
Sbjct: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCP 1541
Score = 41.6 bits (96), Expect = 0.002
Identities = 75/374 (20%), Positives = 143/374 (38%), Gaps = 25/374 (6%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQ----------TCAV 95
K Y+ K I + + +GL E + QALI+ N +++E+ CA+
Sbjct: 1097 KYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL 1156
Query: 96 LSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI----YLKQF 151
L+ K+ ++ +L K AI ++ + +NLG+CY+ +
Sbjct: 1157 LAKVQM-KAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
Query: 152 NKAQDQLHNALNLNRHD-LTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTL-- 208
A L A++++++ + + + +L A+ Y + T L T
Sbjct: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 209 -GLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKY----RVVA 263
GL+Y++LG Y A E A TN A +F+ A+ + ++
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
Query: 264 CAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASA 323
C + N+ M + + A +A ++ P K + G ++ A
Sbjct: 1336 CFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKA 1394
Query: 324 FHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLY 383
++ + AI+ PK Y AV + + A + A+ + + N V+
Sbjct: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT-NRGVIHE 1453
Query: 384 NQGEKKNALAQYQE 397
G K+NA+ YQ+
Sbjct: 1454 FMGHKQNAMKDYQD 1467
Score = 35.4 bits (80), Expect = 0.13
Identities = 40/194 (20%), Positives = 74/194 (38%), Gaps = 2/194 (1%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLK 105
K YE+ ++ E++ + +A + I+R G +Q ++ Q +L P +
Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYW 955
Query: 106 QVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN 165
K A++ N K N+ + E + Y K A A+
Sbjct: 956 HRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKST 1015
Query: 166 RHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEH 224
D Y G+++ + + AI+ + K + + P+ T+ L GL Y + + A E
Sbjct: 1016 PTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074
Query: 225 LGNALTYDPTNYKA 238
L D N +A
Sbjct: 1075 FTALLNIDHQNSQA 1088
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 70.1 bits (170), Expect = 5e-12
Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 19/310 (6%)
Query: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYI 172
LG++ A+E + +AA +++ + + H +C+ + +F +A + AL +N L Y+
Sbjct: 1283 LGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
Query: 173 MLGKIHLLEGDLDKAIEVYK---KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNAL 229
G ++ G + + K KA+ +P + + G G +QKA+ H A+
Sbjct: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
Query: 230 TYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC--FFGKKKYV 287
DP NY A + G+ A+ A + + N G+ F G K+
Sbjct: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA-AMKISTTAEFLTNRGVIHEFMGHKQN- 1460
Query: 288 AAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVA 347
A+ + A L P +N G ++ +Q++ A + S A+ F P+ + M A+
Sbjct: 1461 -AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT 1519
Query: 348 LTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK---KVSL 404
T L+ E AK +A + + C P +A + +N+ L QY+ E+ K
Sbjct: 1520 NTILKKYEEAKEDFANVI--ESC-PF----WAAVYFNRAHFYYCLKQYELAEEDLNKALS 1572
Query: 405 LKDNSSLEFD 414
LK N +L ++
Sbjct: 1573 LKPNDALVYN 1582
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/257 (22%), Positives = 107/257 (41%), Gaps = 13/257 (5%)
Query: 124 YNEAAKLNQKDWEISHNLGVCYIYLK-----------QFNKAQDQLHNALNLN-RHDLTY 171
++EA K QKD+ + ++ YI + +F KA + A++ + ++ L Y
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
+ L G+ A++ A++ S E LT G+++ +G Q A + +A+T
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471
Query: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAIS 291
+P A AG++ H F A + PE+ + N + KKY A
Sbjct: 1472 NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Query: 292 CLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL 351
PF + +N + ++QY A L+ A++ +P +Y A +
Sbjct: 1532 DFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591
Query: 352 EDIENAKRAYAEAVHLD 368
IE A Y +A+ L+
Sbjct: 1592 GLIEEAMADYNQALDLE 1608
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 7/169 (4%)
Query: 71 YVQALI-----FRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYN 125
Y++A I + +G Q++ F P++ + A +G + AA++ N
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 126 EAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDL 184
A K++ E N GV + ++ A +A+ LN ++ L Y G I+
Sbjct: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 185 DKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
+A + + KA++F PEN +L + L Y++A E N + P
Sbjct: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCP 1541
Score = 43.1 bits (100), Expect = 6e-04
Identities = 81/376 (21%), Positives = 146/376 (38%), Gaps = 29/376 (7%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQ----------TCAV 95
K Y+ K I + + +GL E + QALI+ N +++E+ CA+
Sbjct: 1097 KYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL 1156
Query: 96 LSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI----YLKQF 151
L+ K+ ++ +L K AI ++ + +NLG+CY+ +
Sbjct: 1157 LAKVQM-KAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
Query: 152 NKAQDQLHNALNLNRHDLTY-----IMLGKIHLLEGDL-DKAIEVYKKAVEFSPENTELL 205
A L A++++++ T + KI L+ L D I + A E NT L
Sbjct: 1216 KLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL- 1274
Query: 206 TTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKY----RV 261
GL+Y++LG Y A E A TN A +F+ A+ + ++
Sbjct: 1275 -NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKI 1333
Query: 262 VACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYA 321
C + N+ M + + A +A ++ P K + G ++
Sbjct: 1334 NPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
Query: 322 SAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVL 381
A++ + AI+ PK Y AV + + A + A+ + + N V+
Sbjct: 1393 KAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT-NRGVI 1451
Query: 382 LYNQGEKKNALAQYQE 397
G K+NA+ YQ+
Sbjct: 1452 HEFMGHKQNAMKDYQD 1467
Score = 35.8 bits (81), Expect = 0.097
Identities = 83/419 (19%), Positives = 144/419 (34%), Gaps = 61/419 (14%)
Query: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLK 105
K YE+ ++ E++ + +A + I+R G +Q ++ Q +L P +
Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYW 955
Query: 106 QVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN 165
K A++ N K N+ + E + Y K A A+
Sbjct: 956 HRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKST 1015
Query: 166 RHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEH 224
D Y G+++ + + AI+ + K + + P+ T+ L GL Y + + A E
Sbjct: 1016 PTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074
Query: 225 LGNALTYDPTNYKAILAAGSMMQTHGDFDVA-LTKYRVVAC--AVPESPPL--------- 272
L D N + A G + +D+A T Y++ + E P+
Sbjct: 1075 FTALLNIDHQNSQ---ARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFC 1131
Query: 273 --------------WNNIGMCFFG------------------KKKYVAAISCLKRANYLA 300
WN M KK + AIS +
Sbjct: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191
Query: 301 PFDWKILYNLGLVHL----TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIEN 356
LYNLGL ++ Y A L+ AI+ + A+ T + +++
Sbjct: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
Query: 357 AKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQY----QEMEKKVSLLKDNSSL 411
A Y + LD V LN N+G L QY ++ ++ + + N SL
Sbjct: 1252 ALTDYGIVLLLD-ATETVKLN---TFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 70.1 bits (170), Expect = 5e-12
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 33/322 (10%)
Query: 76 IFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDW 135
+++ G +QE++E ++ L P D +A +L G + A++ Y A + N +
Sbjct: 88 VYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY 147
Query: 136 EISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAV 195
+ +LG L AL G L++A Y KA+
Sbjct: 148 CVRSDLG--------------NLLKAL-------------------GRLEEAKACYLKAI 174
Query: 196 EFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVA 255
E P + LG ++ G A H A+T DP A + G++++ FD A
Sbjct: 175 ETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 234
Query: 256 LTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHL 315
+ Y P + N+ ++ + AI +RA L P NL
Sbjct: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
Query: 316 TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVN 375
A A + A+ P + LA +IE A R Y +A+ + +
Sbjct: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
Query: 376 LNYAVLLYNQGEKKNALAQYQE 397
N A +L QG+ + AL Y+E
Sbjct: 355 SNLASVLQQQGKLQEALMHYKE 376
Score = 62.0 bits (149), Expect = 1e-09
Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 6/228 (2%)
Query: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
++L IH LD++ A++ +P E + LG +Y + G Q+A EH +AL
Sbjct: 49 LLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL 108
Query: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLW---NNIGMCFFGKKKYVA 288
P + + + GD + A+ Y A+ +P L+ +++G +
Sbjct: 109 KPDFIDGYINLAAALVAAGDMEGAVQAY---VSALQYNPDLYCVRSDLGNLLKALGRLEE 165
Query: 289 AISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVAL 348
A +C +A P NLG V + A H A+ P + Y+ L L
Sbjct: 166 AKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVL 225
Query: 349 TNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ 396
+ A AY A+ L + +V+ N A + Y QG A+ Y+
Sbjct: 226 KEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYR 273
Score = 62.0 bits (149), Expect = 1e-09
Identities = 67/277 (24%), Positives = 109/277 (39%), Gaps = 11/277 (3%)
Query: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLT-YIMLGKIHLLEGDLD 185
A K N E NLG Y Q +A + +AL L + YI L + GD++
Sbjct: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
Query: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
A++ Y A++++P+ + + LG L LG ++A A+ P A G +
Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305
G+ +A+ + P + N+G + + A++ RA L+P
Sbjct: 191 FNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 250
Query: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365
+ NL V+ A AI QP + Y LA AL + A+ Y A+
Sbjct: 251 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTAL 310
Query: 366 -----HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQE 397
H D N L N+ QG + A+ Y++
Sbjct: 311 RLCPTHADSLNNLANIK-----REQGNIEEAVRLYRK 342
Score = 60.1 bits (144), Expect = 5e-09
Identities = 65/290 (22%), Positives = 115/290 (39%), Gaps = 9/290 (3%)
Query: 120 AIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIH 178
AI + +A L+ + NLG + F++A AL+L+ H + + L ++
Sbjct: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259
Query: 179 LLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKA 238
+G +D AI+ Y++A+E P + L + G +A + AL PT+ +
Sbjct: 260 YEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS 319
Query: 239 ILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANY 298
+ ++ + G+ + A+ YR PE +N+ + K A+ K A
Sbjct: 320 LNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR 379
Query: 299 LAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAK 358
++P N+G MQ A + AI P + + LA + +I A
Sbjct: 380 ISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 439
Query: 359 RAYAEAVHLDKCNPLVNLNYAVLL--------YNQGEKKNALAQYQEMEK 400
+Y A+ L P N A L Y++ KK ++EK
Sbjct: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEK 489
Score = 49.7 bits (117), Expect = 7e-06
Identities = 45/214 (21%), Positives = 84/214 (39%), Gaps = 15/214 (7%)
Query: 74 ALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQK 133
A ++ +G I +++ ++ L P D +A +L G A + YN A +L
Sbjct: 256 ACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPT 315
Query: 134 DWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL--------TYIMLGKIHLLEGDLD 185
+ +NL + Q + A+ L R L + L + +G L
Sbjct: 316 HADSLNNLA-------NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ 368
Query: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
+A+ YK+A+ SP + + +G ++ Q A + A+ +P A S+
Sbjct: 369 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 428
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC 279
+ G+ A+ YR P+ P + N+ C
Sbjct: 429 HKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 462
Score = 29.6 bits (65), Expect = 7.0
Identities = 27/111 (24%), Positives = 43/111 (38%), Gaps = 6/111 (5%)
Query: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA 360
P + +L L +H ++ + HF + AI P + E Y L ++ A
Sbjct: 42 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101
Query: 361 YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSL 411
Y A+ L +N A L G+ + A+ Y VS L+ N L
Sbjct: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAY------VSALQYNPDL 146
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 70.1 bits (170), Expect = 5e-12
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 33/322 (10%)
Query: 76 IFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDW 135
+++ G +QE++E ++ L P D +A +L G + A++ Y A + N +
Sbjct: 98 VYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY 157
Query: 136 EISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAV 195
+ +LG L AL G L++A Y KA+
Sbjct: 158 CVRSDLG--------------NLLKAL-------------------GRLEEAKACYLKAI 184
Query: 196 EFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVA 255
E P + LG ++ G A H A+T DP A + G++++ FD A
Sbjct: 185 ETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 244
Query: 256 LTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHL 315
+ Y P + N+ ++ + AI +RA L P NL
Sbjct: 245 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 304
Query: 316 TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVN 375
A A + A+ P + LA +IE A R Y +A+ + +
Sbjct: 305 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 364
Query: 376 LNYAVLLYNQGEKKNALAQYQE 397
N A +L QG+ + AL Y+E
Sbjct: 365 SNLASVLQQQGKLQEALMHYKE 386
Score = 62.0 bits (149), Expect = 1e-09
Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 6/228 (2%)
Query: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
++L IH LD++ A++ +P E + LG +Y + G Q+A EH +AL
Sbjct: 59 LLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL 118
Query: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLW---NNIGMCFFGKKKYVA 288
P + + + GD + A+ Y A+ +P L+ +++G +
Sbjct: 119 KPDFIDGYINLAAALVAAGDMEGAVQAY---VSALQYNPDLYCVRSDLGNLLKALGRLEE 175
Query: 289 AISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVAL 348
A +C +A P NLG V + A H A+ P + Y+ L L
Sbjct: 176 AKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVL 235
Query: 349 TNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ 396
+ A AY A+ L + +V+ N A + Y QG A+ Y+
Sbjct: 236 KEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYR 283
Score = 62.0 bits (149), Expect = 1e-09
Identities = 67/277 (24%), Positives = 109/277 (39%), Gaps = 11/277 (3%)
Query: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLT-YIMLGKIHLLEGDLD 185
A K N E NLG Y Q +A + +AL L + YI L + GD++
Sbjct: 81 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140
Query: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
A++ Y A++++P+ + + LG L LG ++A A+ P A G +
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305
G+ +A+ + P + N+G + + A++ RA L+P
Sbjct: 201 FNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 260
Query: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365
+ NL V+ A AI QP + Y LA AL + A+ Y A+
Sbjct: 261 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTAL 320
Query: 366 -----HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQE 397
H D N L N+ QG + A+ Y++
Sbjct: 321 RLCPTHADSLNNLANIK-----REQGNIEEAVRLYRK 352
Score = 60.1 bits (144), Expect = 5e-09
Identities = 65/290 (22%), Positives = 115/290 (39%), Gaps = 9/290 (3%)
Query: 120 AIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIH 178
AI + +A L+ + NLG + F++A AL+L+ H + + L ++
Sbjct: 210 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 269
Query: 179 LLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKA 238
+G +D AI+ Y++A+E P + L + G +A + AL PT+ +
Sbjct: 270 YEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS 329
Query: 239 ILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANY 298
+ ++ + G+ + A+ YR PE +N+ + K A+ K A
Sbjct: 330 LNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR 389
Query: 299 LAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAK 358
++P N+G MQ A + AI P + + LA + +I A
Sbjct: 390 ISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 449
Query: 359 RAYAEAVHLDKCNPLVNLNYAVLL--------YNQGEKKNALAQYQEMEK 400
+Y A+ L P N A L Y++ KK ++EK
Sbjct: 450 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEK 499
Score = 49.7 bits (117), Expect = 7e-06
Identities = 45/214 (21%), Positives = 84/214 (39%), Gaps = 15/214 (7%)
Query: 74 ALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQK 133
A ++ +G I +++ ++ L P D +A +L G A + YN A +L
Sbjct: 266 ACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPT 325
Query: 134 DWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL--------TYIMLGKIHLLEGDLD 185
+ +NL + Q + A+ L R L + L + +G L
Sbjct: 326 HADSLNNLA-------NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ 378
Query: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
+A+ YK+A+ SP + + +G ++ Q A + A+ +P A S+
Sbjct: 379 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 438
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC 279
+ G+ A+ YR P+ P + N+ C
Sbjct: 439 HKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 472
Score = 29.6 bits (65), Expect = 7.0
Identities = 27/111 (24%), Positives = 43/111 (38%), Gaps = 6/111 (5%)
Query: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA 360
P + +L L +H ++ + HF + AI P + E Y L ++ A
Sbjct: 52 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 111
Query: 361 YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSL 411
Y A+ L +N A L G+ + A+ Y VS L+ N L
Sbjct: 112 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAY------VSALQYNPDL 156
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 63.2 bits (152), Expect = 6e-10
Identities = 93/442 (21%), Positives = 168/442 (38%), Gaps = 72/442 (16%)
Query: 6 VATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGL 65
+A + +FP +T++ ++ A + ++ Y+ LQE L
Sbjct: 128 IAEQKRFPFATDNDSTNEELAIAYVLIGSGL-----------YDEAIRHFSTMLQEEPDL 176
Query: 66 CEYAIYVQALIFRLEG--NIQES-LELFQTCAV--LSPQSADNLKQVARSLFLLGKHKAA 120
AIY + + + +G +I+ + L LF+ V L P + +Q A L LG+ A
Sbjct: 177 VS-AIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEA 235
Query: 121 IEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYIMLGKIHL 179
+ +A +L Q + + G Y + + A + +L LN++ + + G
Sbjct: 236 VNDLTKAIQL-QPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFF 294
Query: 180 LEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAI 239
G L +AIE +K+A++ + + +LG Y +LG ++ A E AL + + + +
Sbjct: 295 HRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTL 354
Query: 240 LAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYL 299
G M+ HG AL + KR L
Sbjct: 355 QLRGMMLYHHGSLQEALKNF----------------------------------KRCLQL 380
Query: 300 APFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKR 359
P++ Y GL H+ M Q+ + + P G+ + + L R
Sbjct: 381 EPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYL-------R 433
Query: 360 AYAEAVHLDKCNPLVNLNYAVLL---YNQGEKKN---ALAQYQEMEKKVSLLKDNSSLEF 413
Y+ +H PL N V L + KN + Y+E +KD F
Sbjct: 434 EYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNF 493
Query: 414 DS------EMVEMAQKLGAALQ 429
+S E++ +A +LG+ +Q
Sbjct: 494 ESYKPEVQELICVADRLGSLMQ 515
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/286 (21%), Positives = 112/286 (39%), Gaps = 13/286 (4%)
Query: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
+E++ L + P+ AD +A L + K A E+Y K ++ +N GV
Sbjct: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV 516
Query: 144 CYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
+ KA A+ L+ H + + LG+++ G+ A E YK+A++ +
Sbjct: 517 FLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA-HKA 575
Query: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
E+L+ LG LY G Y++A + A P+ + LA ++ G A +
Sbjct: 576 EILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI 635
Query: 263 ACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNL----GLVHLTMQ 318
+ + + ++ + A+ + +A L P D K++ L G
Sbjct: 636 VSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQN 695
Query: 319 QYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEA 364
AF A+ P + +M N+ I++ K Y A
Sbjct: 696 LLDKAFESYRVAVQLNPDQAQAWM-------NMGGIQHIKGKYVSA 734
Score = 60.8 bits (146), Expect = 3e-09
Identities = 64/262 (24%), Positives = 101/262 (38%), Gaps = 39/262 (14%)
Query: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
+E+ E++QT P S+D L G + A+ Y +A KL+ NLG
Sbjct: 491 KEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGR 550
Query: 144 CYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTE 203
Y L + + A++ AL + LG ++ G ++A+++Y++A P E
Sbjct: 551 LYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRE 610
Query: 204 LLTTLGLLYLQLG----------------------------IY------QKAFEHLGNAL 229
L L + +G IY KA + + AL
Sbjct: 611 LRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKAL 670
Query: 230 TYDPTNYKAI----LAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKK 285
P + K I G+ ++ D A YRV P+ W N+G K K
Sbjct: 671 QLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGK 730
Query: 286 YVAAISCLKRANYLAPFDWKIL 307
YV+A + +RA L P D K+L
Sbjct: 731 YVSARAYYERALQLVP-DSKLL 751
Score = 53.5 bits (127), Expect = 5e-07
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 5/259 (1%)
Query: 137 ISHNLGVCYIY---LKQFNKAQDQL-HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
+ HN V Y Y LK + ++ + H L + L + L D +A Y+
Sbjct: 371 LPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQ 430
Query: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
+A++ P++ L LG L ++A L +++ Y P A + S++ F
Sbjct: 431 RALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERF 490
Query: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGL 312
A Y+ P+S L NN G+ A++ ++A L+P + NLG
Sbjct: 491 KEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGR 550
Query: 313 VHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNP 372
++ ++ + + A + A+ K E+ L N E A + Y EA L
Sbjct: 551 LYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQR 609
Query: 373 LVNLNYAVLLYNQGEKKNA 391
+ L A +L G+ K A
Sbjct: 610 ELRLALAQVLAVMGQTKEA 628
Score = 49.7 bits (117), Expect = 7e-06
Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 3/168 (1%)
Query: 233 PTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISC 292
P N K + ++ G A+ YR P NN+G + A
Sbjct: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMY 428
Query: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLE 352
+RA L P + L+NLG + + ++ A L +I + P+ + Y LA L E
Sbjct: 429 YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQE 488
Query: 353 DIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK 400
+ A+ Y + + ++ NY V L + G + A+A YQ+ K
Sbjct: 489 RFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 34/223 (15%)
Query: 47 DYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQ 106
DYE KE L+ C A+Y L + + E+L+ F + SA+ L Q
Sbjct: 508 DYEKAAEFYKEALRNDSS-CTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 566
Query: 107 VARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNR 166
+A L+ AIE + + D ++ LG Y D+
Sbjct: 567 IANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELY----------DR--------- 607
Query: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
EGD +A + Y ++ + P N E++ LG Y+ ++KA ++
Sbjct: 608 --------------EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFE 653
Query: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPES 269
A PT K L S + G++ AL Y+ PE+
Sbjct: 654 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPEN 696
Score = 47.8 bits (112), Expect = 2e-05
Identities = 49/249 (19%), Positives = 96/249 (38%), Gaps = 9/249 (3%)
Query: 124 YNEAAK----LNQKDWEISH----NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIM-L 174
YN+A + L +KD + NL Y K F +A A+N +R++ +
Sbjct: 440 YNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNK 499
Query: 175 GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPT 234
G GD +KA E YK+A+ TE L +GL Y +L +A +
Sbjct: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
Query: 235 NYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLK 294
+ + + ++ + + A+ V +P P + + +G + + A
Sbjct: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
Query: 295 RANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDI 354
+ P + +++ LG ++ Q + A + A QP + +++A +
Sbjct: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNY 679
Query: 355 ENAKRAYAE 363
+ A Y +
Sbjct: 680 QKALDTYKD 688
Score = 44.7 bits (104), Expect = 2e-04
Identities = 61/274 (22%), Positives = 111/274 (40%), Gaps = 20/274 (7%)
Query: 102 DNLKQVARSLFLLGKHKAAIEVY-NEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD--QL 158
D+L+Q+ R + KA E Y +AKL E S G Y + + KA +L
Sbjct: 371 DHLRQMER------ERKAMAEKYIMTSAKLIAPVIETSFAAG--YDWCVEVVKASQYVEL 422
Query: 159 HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEF-SPENTELLTTLGLLYLQLGI 217
N L +N+ +TY L + D ++A+E+ K + S + T L LY
Sbjct: 423 ANDLEINKA-VTY-------LRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD 474
Query: 218 YQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIG 277
+ +A + A+ D N A+ G+ + +GD++ A Y+ NIG
Sbjct: 475 FAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIG 534
Query: 278 MCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM 337
+ + + A+ C + + + ++LY + ++ M+ + A +L ++ P
Sbjct: 535 LTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTD 594
Query: 338 GELYMLLAVALTNLEDIENAKRAYAEAVHLDKCN 371
++ L D A + Y E+ CN
Sbjct: 595 PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCN 628
Score = 39.7 bits (91), Expect = 0.007
Identities = 35/149 (23%), Positives = 59/149 (39%), Gaps = 1/149 (0%)
Query: 70 IYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAK 129
+Y A I+ L N +++E + P L ++ G A + Y E+ +
Sbjct: 564 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 623
Query: 130 LNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTY-IMLGKIHLLEGDLDKAI 188
+ E+ LG YI + + KA A + + + +M+ G+ KA+
Sbjct: 624 YFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKAL 683
Query: 189 EVYKKAVEFSPENTELLTTLGLLYLQLGI 217
+ YK PEN E L L L LG+
Sbjct: 684 DTYKDTHRKFPENVECLRFLVRLCTDLGL 712
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 34/223 (15%)
Query: 47 DYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQ 106
DYE KE L+ C A+Y L + + E+L+ F + SA+ L Q
Sbjct: 499 DYEKAAEFYKEALRNDSS-CTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 557
Query: 107 VARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNR 166
+A L+ AIE + + D ++ LG Y D+
Sbjct: 558 IANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELY----------DR--------- 598
Query: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
EGD +A + Y ++ + P N E++ LG Y+ ++KA ++
Sbjct: 599 --------------EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFE 644
Query: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPES 269
A PT K L S + G++ AL Y+ PE+
Sbjct: 645 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPEN 687
Score = 47.8 bits (112), Expect = 2e-05
Identities = 49/249 (19%), Positives = 96/249 (38%), Gaps = 9/249 (3%)
Query: 124 YNEAAK----LNQKDWEISH----NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIM-L 174
YN+A + L +KD + NL Y K F +A A+N +R++ +
Sbjct: 431 YNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNK 490
Query: 175 GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPT 234
G GD +KA E YK+A+ TE L +GL Y +L +A +
Sbjct: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
Query: 235 NYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLK 294
+ + + ++ + + A+ V +P P + + +G + + A
Sbjct: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
Query: 295 RANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDI 354
+ P + +++ LG ++ Q + A + A QP + +++A +
Sbjct: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNY 670
Query: 355 ENAKRAYAE 363
+ A Y +
Sbjct: 671 QKALDTYKD 679
Score = 44.7 bits (104), Expect = 2e-04
Identities = 61/274 (22%), Positives = 111/274 (40%), Gaps = 20/274 (7%)
Query: 102 DNLKQVARSLFLLGKHKAAIEVY-NEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD--QL 158
D+L+Q+ R + KA E Y +AKL E S G Y + + KA +L
Sbjct: 362 DHLRQMER------ERKAMAEKYIMTSAKLIAPVIETSFAAG--YDWCVEVVKASQYVEL 413
Query: 159 HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEF-SPENTELLTTLGLLYLQLGI 217
N L +N+ +TY L + D ++A+E+ K + S + T L LY
Sbjct: 414 ANDLEINKA-VTY-------LRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD 465
Query: 218 YQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIG 277
+ +A + A+ D N A+ G+ + +GD++ A Y+ NIG
Sbjct: 466 FAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIG 525
Query: 278 MCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM 337
+ + + A+ C + + + ++LY + ++ M+ + A +L ++ P
Sbjct: 526 LTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTD 585
Query: 338 GELYMLLAVALTNLEDIENAKRAYAEAVHLDKCN 371
++ L D A + Y E+ CN
Sbjct: 586 PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCN 619
Score = 39.7 bits (91), Expect = 0.007
Identities = 35/149 (23%), Positives = 59/149 (39%), Gaps = 1/149 (0%)
Query: 70 IYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAK 129
+Y A I+ L N +++E + P L ++ G A + Y E+ +
Sbjct: 555 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 614
Query: 130 LNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTY-IMLGKIHLLEGDLDKAI 188
+ E+ LG YI + + KA A + + + +M+ G+ KA+
Sbjct: 615 YFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKAL 674
Query: 189 EVYKKAVEFSPENTELLTTLGLLYLQLGI 217
+ YK PEN E L L L LG+
Sbjct: 675 DTYKDTHRKFPENVECLRFLVRLCTDLGL 703
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/337 (21%), Positives = 140/337 (41%), Gaps = 41/337 (12%)
Query: 82 NIQESLELFQT---------CAVLSPQ-SADNLKQVARSLFL-----LGKHKAAIEVYNE 126
NI +SLE+ + + ++PQ A NL++ A + +GK A+ YN
Sbjct: 428 NINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNC 487
Query: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDK 186
+N SH+ ++ L Q +A +L + R + ++ +E +
Sbjct: 488 KEAINILSHLPSHHYNTGWV-LCQIGRAYFELSEYMQAER------IFSEVRRIENYRVE 540
Query: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALT-YDPTNYKAILAAGSM 245
+E+Y L +LQ + A L LT D + +A AAG+
Sbjct: 541 GMEIYSTT---------------LWHLQKDV---ALSVLSKDLTDMDKNSPEAWCAAGNC 582
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305
+ D+A+ ++ P + +G F ++ A++C + A + P +
Sbjct: 583 FSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYN 642
Query: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365
Y LG+++ ++++ A A++ P+ L + V L+ E A +A+
Sbjct: 643 AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 702
Query: 366 HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKV 402
+D NPL + A +L+ + K+AL + +E+++ V
Sbjct: 703 VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 739
Score = 56.6 bits (135), Expect = 5e-08
Identities = 60/274 (21%), Positives = 109/274 (39%), Gaps = 17/274 (6%)
Query: 104 LKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALN 163
L Q+ R+ F L ++ A +++E ++ ++ + IY Q + AL+
Sbjct: 508 LCQIGRAYFELSEYMQAERIFSEVRRIE------NYRVEGMEIYSTTLWHLQKDV--ALS 559
Query: 164 LNRHDLT---------YIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQ 214
+ DLT + G L+ + D AI+ +++A++ P T LG ++
Sbjct: 560 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 619
Query: 215 LGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWN 274
KA NA+ +P +Y A G + F +A ++ P+S L
Sbjct: 620 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLC 679
Query: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQ 334
+IG+ KK A+ L +A + P + ++ V ++Y SA L
Sbjct: 680 HIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 739
Query: 335 PKMGELYMLLAVALTNLEDIENAKRAYAEAVHLD 368
PK +Y L+ L A ++ A+ LD
Sbjct: 740 PKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD 773
Score = 53.9 bits (128), Expect = 3e-07
Identities = 46/236 (19%), Positives = 99/236 (41%), Gaps = 1/236 (0%)
Query: 102 DNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNA 161
+ ++ + +L+ L K A + + +++ E G C+ ++ + A A
Sbjct: 540 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRA 599
Query: 162 LNLN-RHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQK 220
+ ++ + Y +LG +L +LDKA+ ++ A+ +P + LG++Y + +
Sbjct: 600 IQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSL 659
Query: 221 AFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280
A H AL +P + + G + + AL P++P +
Sbjct: 660 AEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL 719
Query: 281 FGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPK 336
F +KY +A+ L+ + P + + + +G V+ + Q A S A++ PK
Sbjct: 720 FANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 775
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/337 (21%), Positives = 140/337 (41%), Gaps = 41/337 (12%)
Query: 82 NIQESLELFQT---------CAVLSPQ-SADNLKQVARSLFL-----LGKHKAAIEVYNE 126
NI +SLE+ + + ++PQ A NL++ A + +GK A+ YN
Sbjct: 422 NINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNC 481
Query: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDK 186
+N SH+ ++ L Q +A +L + R + ++ +E +
Sbjct: 482 KEAINILSHLPSHHYNTGWV-LCQIGRAYFELSEYMQAER------IFSEVRRIENYRVE 534
Query: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALT-YDPTNYKAILAAGSM 245
+E+Y L +LQ + A L LT D + +A AAG+
Sbjct: 535 GMEIYSTT---------------LWHLQKDV---ALSVLSKDLTDMDKNSPEAWCAAGNC 576
Query: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305
+ D+A+ ++ P + +G F ++ A++C + A + P +
Sbjct: 577 FSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYN 636
Query: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365
Y LG+++ ++++ A A++ P+ L + V L+ E A +A+
Sbjct: 637 AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696
Query: 366 HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKV 402
+D NPL + A +L+ + K+AL + +E+++ V
Sbjct: 697 VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 733
Score = 56.6 bits (135), Expect = 5e-08
Identities = 60/274 (21%), Positives = 109/274 (39%), Gaps = 17/274 (6%)
Query: 104 LKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALN 163
L Q+ R+ F L ++ A +++E ++ ++ + IY Q + AL+
Sbjct: 502 LCQIGRAYFELSEYMQAERIFSEVRRIE------NYRVEGMEIYSTTLWHLQKDV--ALS 553
Query: 164 LNRHDLT---------YIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQ 214
+ DLT + G L+ + D AI+ +++A++ P T LG ++
Sbjct: 554 VLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613
Query: 215 LGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWN 274
KA NA+ +P +Y A G + F +A ++ P+S L
Sbjct: 614 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLC 673
Query: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQ 334
+IG+ KK A+ L +A + P + ++ V ++Y SA L
Sbjct: 674 HIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIV 733
Query: 335 PKMGELYMLLAVALTNLEDIENAKRAYAEAVHLD 368
PK +Y L+ L A ++ A+ LD
Sbjct: 734 PKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLD 767
Score = 53.9 bits (128), Expect = 3e-07
Identities = 46/236 (19%), Positives = 99/236 (41%), Gaps = 1/236 (0%)
Query: 102 DNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNA 161
+ ++ + +L+ L K A + + +++ E G C+ ++ + A A
Sbjct: 534 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRA 593
Query: 162 LNLN-RHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQK 220
+ ++ + Y +LG +L +LDKA+ ++ A+ +P + LG++Y + +
Sbjct: 594 IQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSL 653
Query: 221 AFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280
A H AL +P + + G + + AL P++P +
Sbjct: 654 AEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL 713
Query: 281 FGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPK 336
F +KY +A+ L+ + P + + + +G V+ + Q A S A++ PK
Sbjct: 714 FANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
>gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens]
Length = 873
Score = 57.8 bits (138), Expect = 2e-08
Identities = 72/342 (21%), Positives = 139/342 (40%), Gaps = 33/342 (9%)
Query: 68 YAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEA 127
+ +Y+Q + ++L +F A L P+ + L L +H+A + +
Sbjct: 137 FVLYLQGQCLFEQCAFLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNE 196
Query: 128 AKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGK---------- 176
K + + ++ Y +L++ + LH+AL LN +H ++L K
Sbjct: 197 LKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQ 256
Query: 177 ---IHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
I ++G L A++ +A+E +P + L G +Y +L + A E L
Sbjct: 257 DAGILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVT 316
Query: 234 TNYKAIL--AAGSMMQTHGDFDVALTKYRVVACAV----------PESPPLWNNIGMCFF 281
+ + ++ A ++ T+ DF V + V + L+ N G CFF
Sbjct: 317 EDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFF 376
Query: 282 GKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTM-------QQYASAFHFLSAAINFQ 334
A + ++A L+P D +GL+ M +Q+ A + S AI
Sbjct: 377 QLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHN 436
Query: 335 PKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNL 376
P+ + Y+ A + L++I A++ A + L+ P ++L
Sbjct: 437 PQKAQYYLYRAKSRQLLQNIFGARQDVATVLLLNPKQPKLSL 478
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/304 (22%), Positives = 113/304 (37%), Gaps = 39/304 (12%)
Query: 81 GNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
G + +LF++ + P +A + ++L G AAI Y EA +LN K +N
Sbjct: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
Query: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPE 200
LG LK+ N+ Q+ A E+ AV+ P+
Sbjct: 522 LGNI---LKERNELQE------------------------------AEELLSLAVQIQPD 548
Query: 201 NTELLTTLGLLYLQLGIYQKAFEHLGNALTYD---PTNYKAILAAGSMMQTHGDFDVALT 257
LG++ L ++ A + A+ + P Y + + + H D AL
Sbjct: 549 FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD---ALN 605
Query: 258 KYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTM 317
+R PE WNN+ + A + + A L P D ++++L V
Sbjct: 606 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 665
Query: 318 QQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLN 377
Q+Y + AI P + LAV ++ AK+ Y ++ LD N
Sbjct: 666 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 725
Query: 378 YAVL 381
Y +L
Sbjct: 726 YGLL 729
Score = 50.1 bits (118), Expect = 5e-06
Identities = 52/241 (21%), Positives = 96/241 (39%), Gaps = 3/241 (1%)
Query: 174 LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
+GK +G+ AI Y++AV +P+ + LG + + Q+A E L A+ P
Sbjct: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 547
Query: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293
A + G + + F+ A YR + P + N+G + ++V A++
Sbjct: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAW 607
Query: 294 KRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLED 353
+ A L P N+ ++ A A A+ P L LA L +
Sbjct: 608 RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQK 667
Query: 354 IENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ---EMEKKVSLLKDNSS 410
+ ++ + +A+ + + N AVL + G A Y+ +++ S K+N
Sbjct: 668 YKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYG 727
Query: 411 L 411
L
Sbjct: 728 L 728
Score = 44.3 bits (103), Expect = 3e-04
Identities = 51/213 (23%), Positives = 86/213 (40%), Gaps = 10/213 (4%)
Query: 208 LGLLY-------LQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYR 260
LG+L+ L+ G ++ + +AL+ P N K G + G+ A+ YR
Sbjct: 447 LGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYR 506
Query: 261 VVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQY 320
P+ NN+G + + A L A + P NLG+V +++++
Sbjct: 507 EAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRF 566
Query: 321 ASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAV 380
+A AI + K + Y L +L +A A+ A L + L N +
Sbjct: 567 EAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMII 626
Query: 381 LLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEF 413
LL N G A A +E + L+ ++ SL F
Sbjct: 627 LLDNTGNLAQAEAVGRE---ALELIPNDHSLMF 656
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/304 (22%), Positives = 113/304 (37%), Gaps = 39/304 (12%)
Query: 81 GNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
G + +LF++ + P +A + ++L G AAI Y EA +LN K +N
Sbjct: 481 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 540
Query: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPE 200
LG LK+ N+ Q+ A E+ AV+ P+
Sbjct: 541 LGNI---LKERNELQE------------------------------AEELLSLAVQIQPD 567
Query: 201 NTELLTTLGLLYLQLGIYQKAFEHLGNALTYD---PTNYKAILAAGSMMQTHGDFDVALT 257
LG++ L ++ A + A+ + P Y + + + H D AL
Sbjct: 568 FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD---ALN 624
Query: 258 KYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTM 317
+R PE WNN+ + A + + A L P D ++++L V
Sbjct: 625 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 684
Query: 318 QQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLN 377
Q+Y + AI P + LAV ++ AK+ Y ++ LD N
Sbjct: 685 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 744
Query: 378 YAVL 381
Y +L
Sbjct: 745 YGLL 748
Score = 50.1 bits (118), Expect = 5e-06
Identities = 52/241 (21%), Positives = 96/241 (39%), Gaps = 3/241 (1%)
Query: 174 LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
+GK +G+ AI Y++AV +P+ + LG + + Q+A E L A+ P
Sbjct: 507 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 566
Query: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293
A + G + + F+ A YR + P + N+G + ++V A++
Sbjct: 567 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAW 626
Query: 294 KRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLED 353
+ A L P N+ ++ A A A+ P L LA L +
Sbjct: 627 RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQK 686
Query: 354 IENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ---EMEKKVSLLKDNSS 410
+ ++ + +A+ + + N AVL + G A Y+ +++ S K+N
Sbjct: 687 YKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYG 746
Query: 411 L 411
L
Sbjct: 747 L 747
Score = 44.3 bits (103), Expect = 3e-04
Identities = 51/213 (23%), Positives = 86/213 (40%), Gaps = 10/213 (4%)
Query: 208 LGLLY-------LQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYR 260
LG+L+ L+ G ++ + +AL+ P N K G + G+ A+ YR
Sbjct: 466 LGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYR 525
Query: 261 VVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQY 320
P+ NN+G + + A L A + P NLG+V +++++
Sbjct: 526 EAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRF 585
Query: 321 ASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAV 380
+A AI + K + Y L +L +A A+ A L + L N +
Sbjct: 586 EAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMII 645
Query: 381 LLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEF 413
LL N G A A +E + L+ ++ SL F
Sbjct: 646 LLDNTGNLAQAEAVGRE---ALELIPNDHSLMF 675
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 54.3 bits (129), Expect = 3e-07
Identities = 69/329 (20%), Positives = 122/329 (37%), Gaps = 55/329 (16%)
Query: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYI 172
LG+ A+ +A +L Q + + G Y + + A + +L LN++ + +
Sbjct: 176 LGRINEAVNDLTKAIQL-QPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAML 234
Query: 173 MLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYD 232
G G L +AIE +K+A++ + + +LG Y +LG ++ A E AL +
Sbjct: 235 YKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLN 294
Query: 233 PTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISC 292
+ + + G M+ HG AL +
Sbjct: 295 QNHVQTLQLRGMMLYHHGSLQEALKNF--------------------------------- 321
Query: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLE 352
KR L P++ Y GL H+ M Q+ + + P G+ + + L
Sbjct: 322 -KRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYL- 379
Query: 353 DIENAKRAYAEAVHLDKCNPLVNLNYAVLL---YNQGEKKN---ALAQYQEMEKKVSLLK 406
R Y+ +H PL N V L + KN + Y+E +K
Sbjct: 380 ------REYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIK 433
Query: 407 DNSSLEFDS------EMVEMAQKLGAALQ 429
D F+S E++ +A +LG+ +Q
Sbjct: 434 DVLHQNFESYKPEVQELICVADRLGSLMQ 462
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 1/125 (0%)
Query: 110 SLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL 169
+ F G K AIE + EA K + +LG Y L F A + AL LN++ +
Sbjct: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298
Query: 170 TYIML-GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNA 228
+ L G + G L +A++ +K+ ++ P N GL ++ +G + + +
Sbjct: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
Query: 229 LTYDP 233
+ DP
Sbjct: 359 MLNDP 363
Score = 33.9 bits (76), Expect = 0.37
Identities = 32/156 (20%), Positives = 64/156 (41%), Gaps = 2/156 (1%)
Query: 81 GNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
G I E++ L P SA + F+ + A E + ++ +LN+
Sbjct: 177 GRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235
Query: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSP 199
G+ + + +A + AL + Y LG+ + G+ + A E ++KA+ +
Sbjct: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 295
Query: 200 ENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTN 235
+ + L G++ G Q+A ++ L +P N
Sbjct: 296 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYN 331
>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
Length = 843
Score = 53.1 bits (126), Expect = 6e-07
Identities = 53/262 (20%), Positives = 105/262 (40%), Gaps = 16/262 (6%)
Query: 82 NIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNL 141
++ E L++F C V P +Q+A LF LG +A++++ + WE ++
Sbjct: 423 SVLERLKIFYCCQV--PPHWAIQRQLASLLFELGCTSSALQIFEKLEM-----WE---DV 472
Query: 142 GVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPEN 201
+CY Q KA++ L L Y +LG + DKA E+ + +
Sbjct: 473 VICYERAGQHGKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSRY------RS 526
Query: 202 TELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRV 261
+ LL+L+ +Q+ E ++ +P + G D+ + ++
Sbjct: 527 ARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQR 586
Query: 262 VACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYA 321
P++ WNN+ + K+ V A L+ A W+I N L + +++
Sbjct: 587 CVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFS 646
Query: 322 SAFHFLSAAINFQPKMGELYML 343
A ++ + K ++ +L
Sbjct: 647 EAIKAYHRLLDLRDKYKDVQVL 668
Score = 42.7 bits (99), Expect = 8e-04
Identities = 41/201 (20%), Positives = 80/201 (39%), Gaps = 11/201 (5%)
Query: 200 ENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVA--LT 257
E E+ + + Y + G + KA E L L T L G ++ H +D A L+
Sbjct: 464 EKLEMWEDVVICYERAGQHGKAEEILRQELEKKETPSLYCLL-GDVLGDHSCYDKAWELS 522
Query: 258 KYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTM 317
+YR S + + K++ + C +R+ + P + ++LG +L +
Sbjct: 523 RYR--------SARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLAL 574
Query: 318 QQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLN 377
+ Y + + +P E + L+ + L+ A R EA+ + + + N
Sbjct: 575 EDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWEN 634
Query: 378 YAVLLYNQGEKKNALAQYQEM 398
Y + + GE A+ Y +
Sbjct: 635 YILTSTDVGEFSEAIKAYHRL 655
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 1/124 (0%)
Query: 41 LHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQS 100
LH K+++ C + ++ + LE + Q S + FQ C L P +
Sbjct: 536 LHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALE-DYQGSAKAFQRCVTLEPDN 594
Query: 101 ADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHN 160
A+ ++ S L + A EA K N + W+I N + + +F++A H
Sbjct: 595 AEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHR 654
Query: 161 ALNL 164
L+L
Sbjct: 655 LLDL 658
Score = 33.5 bits (75), Expect = 0.48
Identities = 28/128 (21%), Positives = 54/128 (42%), Gaps = 7/128 (5%)
Query: 73 QALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQ 132
+AL+ QE +E F+ ++P + + L ++ + + + L
Sbjct: 533 KALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEP 592
Query: 133 KDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLE----GDLDKAI 188
+ E +NL YI LKQ KA L AL N + + + ++L G+ +AI
Sbjct: 593 DNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCN---YEHWQIWENYILTSTDVGEFSEAI 649
Query: 189 EVYKKAVE 196
+ Y + ++
Sbjct: 650 KAYHRLLD 657
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 52.8 bits (125), Expect = 8e-07
Identities = 71/363 (19%), Positives = 140/363 (38%), Gaps = 41/363 (11%)
Query: 82 NIQESLELFQTCAVLSPQSADNLKQVARSLFLLG-----KHKAAIEVYNEAAKLNQKDWE 136
+I+ ++L + P + L +A F +H A +N + Q E
Sbjct: 250 SIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQA--E 307
Query: 137 ISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD--LTYIMLGKIHLLEGDLDKAIEVYKKA 194
+ L + + +++A + A L + LG++++ GD + A + ++K
Sbjct: 308 SCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKV 367
Query: 195 VEFSPENTELLTTLGLLYLQLGIYQK---AFEHLGNALTYDPTNYKAILAAGSMMQTHGD 251
++ P N E + LG LY +K A HL P + +A + +++ D
Sbjct: 368 LKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILE-QTD 426
Query: 252 FDVALTKYRVVACAVPES------PPLWNNIGMCFF-------GKKKYVAAISCLKR--- 295
AL+ Y + E P + NN+G F KK ++A++ K
Sbjct: 427 IQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAE 486
Query: 296 --ANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLED 353
+Y YNL ++ M ++ A + P + Y+ L + +
Sbjct: 487 HDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGN 546
Query: 354 IENAKRAYAEAVHLDKCNP-----LVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDN 408
A + EA+ +++ +P + NL+ A + G+KK ++ + K+ S D
Sbjct: 547 FYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKK-----FERILKQPSTQSDT 601
Query: 409 SSL 411
S+
Sbjct: 602 YSM 604
Score = 44.3 bits (103), Expect = 3e-04
Identities = 61/257 (23%), Positives = 110/257 (42%), Gaps = 36/257 (14%)
Query: 72 VQALIFRLEGNIQESLELFQTCAVLSPQSAD------NLKQVARSLFLLGKHKAAIEVYN 125
V AL FRL GN+ E+ + F + A+ N V S L ++A E ++
Sbjct: 457 VGALHFRL-GNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCE-FH 514
Query: 126 EAAKLNQKDWEISHNLGVCYIYLK-------QFNKAQDQLHNALNLNR-HDLTYIMLGKI 177
EA KL + N CY+ L F +A D AL +N+ H + ++G +
Sbjct: 515 EAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNL 574
Query: 178 HLLEGDLDKAIEVYKKAVE--FSPENTELLTTLGLLYLQLGIYQ------KAFEHLGNAL 229
HL + + + +++ ++ + +T + LG ++LQ ++Q K H AL
Sbjct: 575 HLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQT-LHQPTRDREKEKRHQDRAL 633
Query: 230 TY-------DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFG 282
D N A G+++ G F A + V A + +W N+ +
Sbjct: 634 AIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVE 693
Query: 283 KKKYVAAI----SCLKR 295
+K+Y++A+ +CL++
Sbjct: 694 QKQYISAVQMYENCLRK 710
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 52.4 bits (124), Expect = 1e-06
Identities = 52/246 (21%), Positives = 104/246 (42%), Gaps = 21/246 (8%)
Query: 171 YIMLGKIHLLEGDLDKAIEVYKKAVEFSPE---NTELLTTLGLLYLQLGIYQKAFEHLGN 227
+ LG +LL D KA+ Y++ + N L LGL+Y +Q A +
Sbjct: 96 FCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQE 155
Query: 228 ALTYDPTNYKA---ILAAGSMMQTHGDFDVALTKYR--VVAC--AVPESPPLWNNIGMCF 280
L DP+ +A L G M + + D++ +L ++ +V C + + +I +
Sbjct: 156 VLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLY 215
Query: 281 FGKKKYVAAISC----LKRANYLAPFDWKILYNLGLVHLTMQ-------QYASAFHFLSA 329
++KY +A L+ N A +L LG +H T+ + + A +L
Sbjct: 216 ETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQK 275
Query: 330 AINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKK 389
++ P G+ + L +++ +++A +Y +++ + + + VL Q +
Sbjct: 276 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 335
Query: 390 NALAQY 395
+AL Y
Sbjct: 336 DALQAY 341
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 52.0 bits (123), Expect = 1e-06
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 11/141 (7%)
Query: 273 WNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAIN 332
W N+G + K A S + A Y +LYNLGL+ ++A A H+ AI
Sbjct: 496 WGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIG 555
Query: 333 FQPKMGELYMLLAVALTNLEDIENAKRAYAEA----------VHLDKCNPLVNL-NYAVL 381
+P + Y+ + L N E A+R + + H K + L N L
Sbjct: 556 SRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKL 615
Query: 382 LYNQGEKKNALAQYQEMEKKV 402
+ QG + AL+ Y+E +K+
Sbjct: 616 YHEQGHYEEALSVYKEAIQKM 636
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/263 (21%), Positives = 100/263 (38%), Gaps = 25/263 (9%)
Query: 75 LIFRLEGNIQESLELFQTCAVLSPQSADN----LKQVARSLFLLGK-------HKAAIEV 123
+I +G +E+ F C+ + ++ + V L+ LGK ++ A+ V
Sbjct: 569 IILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSV 628
Query: 124 YNEAAKLNQKDW---EISHNLGVCYIYLKQFNKAQDQLHNALNLNR-HDLTYIMLGKIHL 179
Y EA + + + + + +G Y+ L + +A+ +L H ++ GK+
Sbjct: 629 YKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLA 688
Query: 180 LEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAI 239
L G +A +++ KA+E P G L+ +A E A D T + +
Sbjct: 689 LTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVV 748
Query: 240 LAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYL 299
A M++ + A Y + A P P N+G + A + RA L
Sbjct: 749 FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQL 808
Query: 300 APFD----------WKILYNLGL 312
P D W I+ GL
Sbjct: 809 KPDDVITQSNLRKLWNIMEKQGL 831
Score = 42.0 bits (97), Expect = 0.001
Identities = 55/258 (21%), Positives = 100/258 (38%), Gaps = 29/258 (11%)
Query: 174 LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
LG + + + +A Y+ A+ + ++L LGLL + + +A + A+ P
Sbjct: 499 LGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP 558
Query: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACA-VPESPPLWNNIGMCFFGKKKYVAAISC 292
T A L G ++ G + A + + C+ +P+ N+ K + SC
Sbjct: 559 TLASAYLNTGIILMNQGRTEEARRTF--LKCSEIPDE-----NLKDPHAHKS---SVTSC 608
Query: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM---GELYMLLAVALT 349
L YNLG ++ Y A AI P+ LY ++ A
Sbjct: 609 L--------------YNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYM 654
Query: 350 NLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNS 409
L + A+ Y E++ + +L Y LL G K A + + ++ K N
Sbjct: 655 RLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLK-AIELDPTKGNC 713
Query: 410 SLEFDSEMVEMAQKLGAA 427
+ + ++E A+ + AA
Sbjct: 714 YMHYGQFLLEEARLIEAA 731
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 50.4 bits (119), Expect = 4e-06
Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 34/257 (13%)
Query: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
+++LE++ +P A ++ + ++ AIE Y A K+N +D+ + +LG
Sbjct: 746 EKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDF-LCCDLGK 804
Query: 144 CYIYLKQFNKAQDQLHNALNLNRHDLT------------YIMLGKI---HLLEG---DLD 185
+ LK+ NKA+ L AL HD+ ++L K+ H E L+
Sbjct: 805 LLLKLKKVNKAEKVLKQAL---EHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 861
Query: 186 KAIEVYKKAVEFSP-ENTELLTTLGLL-----------YLQLGIYQKAFEHLGNALTYDP 233
KA+++ + ++ P E E++ + L YL Y KA + + +Y P
Sbjct: 862 KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLP 921
Query: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293
T+ K +L + G D+ ++ + F K+K+ AAI+
Sbjct: 922 TDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLY 981
Query: 294 KRANYLAPFDWKILYNL 310
+ AP ++ +L+ L
Sbjct: 982 HQVLEKAPDNFLVLHKL 998
Score = 34.3 bits (77), Expect = 0.28
Identities = 44/205 (21%), Positives = 88/205 (42%), Gaps = 9/205 (4%)
Query: 25 KAPEFP-ILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNI 83
KA ++P ++ +I L ++K E + ++ +Q +Q V+AL RL G +
Sbjct: 585 KAGDYPEAIKTLKMVIKLPALKK--EEGRKFLRPSVQPSQRASILLELVEAL--RLNGEL 640
Query: 84 QESLELFQ-TCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLG 142
E+ ++ Q T +N +A +L K + + L ++ +
Sbjct: 641 HEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREK 700
Query: 143 VCYIYLKQFNKAQDQLHNALNLNRH---DLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSP 199
+ IYL+ + + L H T ++LG + + +KA+EVY +A +P
Sbjct: 701 MANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNP 760
Query: 200 ENTELLTTLGLLYLQLGIYQKAFEH 224
+ L + +G Y++ Y +A E+
Sbjct: 761 HDASLASRIGHAYVKAHQYTEAIEY 785
Score = 30.0 bits (66), Expect = 5.3
Identities = 37/151 (24%), Positives = 60/151 (39%), Gaps = 28/151 (18%)
Query: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPE 200
L Y++LKQ KA+ QL L K V +A + E
Sbjct: 1168 LAQAYVFLKQIPKARMQLKR-----------------------LAKTPWVLSEAEDL--E 1202
Query: 201 NTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYR 260
+ LL L +Y Q + A E L + Y+ + YKA G +M+ + A+T Y+
Sbjct: 1203 KSWLL--LADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1260
Query: 261 VV-ACAVPESPPLWNNIGMCFFGKKKYVAAI 290
+ + +P + + + KK+V AI
Sbjct: 1261 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAI 1291
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 50.4 bits (119), Expect = 4e-06
Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 34/257 (13%)
Query: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
+++LE++ +P A ++ + ++ AIE Y A K+N +D+ + +LG
Sbjct: 745 EKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDF-LCCDLGK 803
Query: 144 CYIYLKQFNKAQDQLHNALNLNRHDLT------------YIMLGKI---HLLEG---DLD 185
+ LK+ NKA+ L AL HD+ ++L K+ H E L+
Sbjct: 804 LLLKLKKVNKAEKVLKQAL---EHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 860
Query: 186 KAIEVYKKAVEFSP-ENTELLTTLGLL-----------YLQLGIYQKAFEHLGNALTYDP 233
KA+++ + ++ P E E++ + L YL Y KA + + +Y P
Sbjct: 861 KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLP 920
Query: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293
T+ K +L + G D+ ++ + F K+K+ AAI+
Sbjct: 921 TDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLY 980
Query: 294 KRANYLAPFDWKILYNL 310
+ AP ++ +L+ L
Sbjct: 981 HQVLEKAPDNFLVLHKL 997
Score = 34.3 bits (77), Expect = 0.28
Identities = 44/205 (21%), Positives = 88/205 (42%), Gaps = 9/205 (4%)
Query: 25 KAPEFP-ILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNI 83
KA ++P ++ +I L ++K E + ++ +Q +Q V+AL RL G +
Sbjct: 584 KAGDYPEAIKTLKMVIKLPALKK--EEGRKFLRPSVQPSQRASILLELVEAL--RLNGEL 639
Query: 84 QESLELFQ-TCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLG 142
E+ ++ Q T +N +A +L K + + L ++ +
Sbjct: 640 HEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREK 699
Query: 143 VCYIYLKQFNKAQDQLHNALNLNRH---DLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSP 199
+ IYL+ + + L H T ++LG + + +KA+EVY +A +P
Sbjct: 700 MANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNP 759
Query: 200 ENTELLTTLGLLYLQLGIYQKAFEH 224
+ L + +G Y++ Y +A E+
Sbjct: 760 HDASLASRIGHAYVKAHQYTEAIEY 784
Score = 30.0 bits (66), Expect = 5.3
Identities = 37/151 (24%), Positives = 60/151 (39%), Gaps = 28/151 (18%)
Query: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPE 200
L Y++LKQ KA+ QL L K V +A + E
Sbjct: 1167 LAQAYVFLKQIPKARMQLKR-----------------------LAKTPWVLSEAEDL--E 1201
Query: 201 NTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYR 260
+ LL L +Y Q + A E L + Y+ + YKA G +M+ + A+T Y+
Sbjct: 1202 KSWLL--LADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYK 1259
Query: 261 VV-ACAVPESPPLWNNIGMCFFGKKKYVAAI 290
+ + +P + + + KK+V AI
Sbjct: 1260 LAWKYSHHANPAIGFKLAFNYLKDKKFVEAI 1290
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 48.9 bits (115), Expect = 1e-05
Identities = 91/422 (21%), Positives = 165/422 (39%), Gaps = 66/422 (15%)
Query: 38 LIHLHYIRKDYEACKAVIKEQLQETQGLCEYA--IYVQALIFRLEGNIQESLELFQTCAV 95
LI +H + + V+++ + E G E A + +G+I+ +L + Q
Sbjct: 623 LIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQNVTA 682
Query: 96 LSPQSADNLKQVARSLFLLGKHKAA-IEVYNEAAK--LNQKDWEISHNLGVCYIYLKQFN 152
P + +++A K K I + E A+ N + + + LG Y+ + +
Sbjct: 683 EQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLL---LGDAYMNILEPE 739
Query: 153 KAQDQLHNALNLNRHDLTYIM-LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLL 211
+A ALN N D T +GK + + AI Y+ A++ +N L L L
Sbjct: 740 EAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNY-LCYDLAEL 798
Query: 212 YLQLGIYQKAFEHLGNALTYDPTN-YKAILAAG----------SMMQTHGDFDVALTKYR 260
L+L Y KA + L +AL ++P N A++ G S M+ GD AL + R
Sbjct: 799 LLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQAR 858
Query: 261 VVACAV--------PESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGL 312
+ V P++ P +K++AA C + A +
Sbjct: 859 ELQARVLKRVQMEQPDAVP-----------AQKHLAAEICAEIAKH-------------- 893
Query: 313 VHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNP 372
+ + Y A F A+ ++ + LA +D ++ R A + D+ N
Sbjct: 894 -SVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNE 952
Query: 373 LVNLNYAVLLYNQGEKKNALAQYQE-MEKK----------VSLLKDNSSLEFDSEMVEMA 421
+ A L++ + + + A+ Q+ +E+K + LL+ LE MA
Sbjct: 953 AATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMA 1012
Query: 422 QK 423
+K
Sbjct: 1013 EK 1014
>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
Length = 1347
Score = 48.5 bits (114), Expect = 1e-05
Identities = 50/246 (20%), Positives = 102/246 (41%), Gaps = 21/246 (8%)
Query: 171 YIMLGKIHLLEGDLDKAIEVYKKAVEFSPE---NTELLTTLGLLYLQLGIYQKAFEHLGN 227
+ LG +LL D KA+ Y++ + N L LGL+Y + A + +
Sbjct: 93 FCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQD 152
Query: 228 ALTYDPTNYKA---ILAAGSMMQTHGDFDVALTKYR--VVAC--AVPESPPLWNNIGMCF 280
L DP+ +A L G M + + D+ +L ++ ++ C + + +I +
Sbjct: 153 VLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLY 212
Query: 281 FGKKKYVAAISC----LKRANYLAPFDWKILYNLGLVHLTMQ-------QYASAFHFLSA 329
++KY +A L+ N A +L LG +H M + + A +L
Sbjct: 213 ETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQK 272
Query: 330 AINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKK 389
++ P G+ + L +++ +++A +Y +++ + + + VL Q +
Sbjct: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
Query: 390 NALAQY 395
+AL Y
Sbjct: 333 DALQAY 338
Score = 29.3 bits (64), Expect = 9.1
Identities = 37/191 (19%), Positives = 82/191 (42%), Gaps = 18/191 (9%)
Query: 75 LIFRLEGNIQESLELFQTCAV-LSPQSADNLK---QVARSLFLLGKHKAAIEVYNE---- 126
L+F++ + + SL+ FQ + +P + N + +A K+ +A E Y +
Sbjct: 172 LMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT 231
Query: 127 --------AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYIMLGKI 177
A L Q W + HN+ + + + A L +L + + ++ LG+
Sbjct: 232 ENLPAQVKATVLQQLGW-MHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRC 290
Query: 178 HLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYK 237
+ G + A Y+++++ S + + ++G+LY Q A + A+ D +
Sbjct: 291 YSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAA 350
Query: 238 AILAAGSMMQT 248
A + G++ ++
Sbjct: 351 AWMDLGTLYES 361
>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
sapiens]
Length = 1079
Score = 48.5 bits (114), Expect = 1e-05
Identities = 50/246 (20%), Positives = 102/246 (41%), Gaps = 21/246 (8%)
Query: 171 YIMLGKIHLLEGDLDKAIEVYKKAVEFSPE---NTELLTTLGLLYLQLGIYQKAFEHLGN 227
+ LG +LL D KA+ Y++ + N L LGL+Y + A + +
Sbjct: 93 FCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQD 152
Query: 228 ALTYDPTNYKA---ILAAGSMMQTHGDFDVALTKYR--VVAC--AVPESPPLWNNIGMCF 280
L DP+ +A L G M + + D+ +L ++ ++ C + + +I +
Sbjct: 153 VLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLY 212
Query: 281 FGKKKYVAAISC----LKRANYLAPFDWKILYNLGLVHLTMQ-------QYASAFHFLSA 329
++KY +A L+ N A +L LG +H M + + A +L
Sbjct: 213 ETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQK 272
Query: 330 AINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKK 389
++ P G+ + L +++ +++A +Y +++ + + + VL Q +
Sbjct: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
Query: 390 NALAQY 395
+AL Y
Sbjct: 333 DALQAY 338
Score = 29.3 bits (64), Expect = 9.1
Identities = 37/191 (19%), Positives = 82/191 (42%), Gaps = 18/191 (9%)
Query: 75 LIFRLEGNIQESLELFQTCAV-LSPQSADNLK---QVARSLFLLGKHKAAIEVYNE---- 126
L+F++ + + SL+ FQ + +P + N + +A K+ +A E Y +
Sbjct: 172 LMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT 231
Query: 127 --------AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYIMLGKI 177
A L Q W + HN+ + + + A L +L + + ++ LG+
Sbjct: 232 ENLPAQVKATVLQQLGW-MHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRC 290
Query: 178 HLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYK 237
+ G + A Y+++++ S + + ++G+LY Q A + A+ D +
Sbjct: 291 YSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAA 350
Query: 238 AILAAGSMMQT 248
A + G++ ++
Sbjct: 351 AWMDLGTLYES 361
>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
sapiens]
Length = 1240
Score = 48.5 bits (114), Expect = 1e-05
Identities = 50/246 (20%), Positives = 102/246 (41%), Gaps = 21/246 (8%)
Query: 171 YIMLGKIHLLEGDLDKAIEVYKKAVEFSPE---NTELLTTLGLLYLQLGIYQKAFEHLGN 227
+ LG +LL D KA+ Y++ + N L LGL+Y + A + +
Sbjct: 93 FCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQD 152
Query: 228 ALTYDPTNYKA---ILAAGSMMQTHGDFDVALTKYR--VVAC--AVPESPPLWNNIGMCF 280
L DP+ +A L G M + + D+ +L ++ ++ C + + +I +
Sbjct: 153 VLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLY 212
Query: 281 FGKKKYVAAISC----LKRANYLAPFDWKILYNLGLVHLTMQ-------QYASAFHFLSA 329
++KY +A L+ N A +L LG +H M + + A +L
Sbjct: 213 ETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQK 272
Query: 330 AINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKK 389
++ P G+ + L +++ +++A +Y +++ + + + VL Q +
Sbjct: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
Query: 390 NALAQY 395
+AL Y
Sbjct: 333 DALQAY 338
Score = 29.3 bits (64), Expect = 9.1
Identities = 37/191 (19%), Positives = 82/191 (42%), Gaps = 18/191 (9%)
Query: 75 LIFRLEGNIQESLELFQTCAV-LSPQSADNLK---QVARSLFLLGKHKAAIEVYNE---- 126
L+F++ + + SL+ FQ + +P + N + +A K+ +A E Y +
Sbjct: 172 LMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT 231
Query: 127 --------AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYIMLGKI 177
A L Q W + HN+ + + + A L +L + + ++ LG+
Sbjct: 232 ENLPAQVKATVLQQLGW-MHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRC 290
Query: 178 HLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYK 237
+ G + A Y+++++ S + + ++G+LY Q A + A+ D +
Sbjct: 291 YSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAA 350
Query: 238 AILAAGSMMQT 248
A + G++ ++
Sbjct: 351 AWMDLGTLYES 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,883,037
Number of Sequences: 37866
Number of extensions: 824600
Number of successful extensions: 3972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 3378
Number of HSP's gapped (non-prelim): 492
length of query: 519
length of database: 18,247,518
effective HSP length: 107
effective length of query: 412
effective length of database: 14,195,856
effective search space: 5848692672
effective search space used: 5848692672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.