Search of human proteins with 254028237

Search of human proteins with 254028237

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|254028237 MAP/microtubule affinity-regulating kinase 2
isoform e [Homo sapiens]
         (719 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...  1433   0.0  
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...  1407   0.0  
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...  1402   0.0  
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...  1384   0.0  
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...  1303   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   938   0.0  
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   920   0.0  
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   912   0.0  
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   905   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   902   0.0  
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   642   0.0  
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor...   492   e-139
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        382   e-106
gi|116256471 SNF1-like kinase [Homo sapiens]                          360   2e-99
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         357   2e-98
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               295   1e-79
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              288   2e-77
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    273   3e-73
gi|156105707 SNF related kinase [Homo sapiens]                        271   2e-72
gi|156105705 SNF related kinase [Homo sapiens]                        271   2e-72
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   266   5e-71
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   265   1e-70
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       255   9e-68
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   254   1e-67
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               253   3e-67
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           253   4e-67
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   220   3e-57
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            191   2e-48
gi|16418343 testis-specific serine kinase 3 [Homo sapiens]            186   9e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens]           183   4e-46

>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score = 1433 bits (3710), Expect = 0.0
 Identities = 719/719 (100%), Positives = 719/719 (100%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420

Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480

Query: 481 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 540
           NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 540

Query: 541 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR 600
           STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR
Sbjct: 541 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR 600

Query: 601 PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE 660
           PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE
Sbjct: 601 PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE 660

Query: 661 KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719
           KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Sbjct: 661 KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score = 1407 bits (3643), Expect = 0.0
 Identities = 712/725 (98%), Positives = 715/725 (98%), Gaps = 7/725 (0%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419

Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479

Query: 481 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 540
           NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR
Sbjct: 480 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 539

Query: 541 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR- 599
           STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNL+   ++ 
Sbjct: 540 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKD 599

Query: 600 -----RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC 654
                RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC
Sbjct: 600 RVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC 659

Query: 655 QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA 714
           QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA
Sbjct: 660 QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA 719

Query: 715 NELKL 719
           NELKL
Sbjct: 720 NELKL 724


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score = 1402 bits (3629), Expect = 0.0
 Identities = 709/719 (98%), Positives = 709/719 (98%), Gaps = 10/719 (1%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419

Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479

Query: 481 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 540
           NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR
Sbjct: 480 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 539

Query: 541 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARR 600
           STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV         RR
Sbjct: 540 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV---------RR 590

Query: 601 PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE 660
           PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE
Sbjct: 591 PHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHE 650

Query: 661 KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719
           KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Sbjct: 651 KYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 709


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score = 1384 bits (3583), Expect = 0.0
 Identities = 714/788 (90%), Positives = 714/788 (90%), Gaps = 69/788 (8%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420

Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480

Query: 481 NRSRNSPLLERASLGQASIQNGKDSTA--------------------------------- 507
           NRSRNSPLLERASLGQASIQNGKDS                                   
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540

Query: 508 -----------------PQRVP----VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 546
                            P   P    VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600

Query: 547 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR------- 599
           QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR       
Sbjct: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660

Query: 600 --------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 651
                   RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720

Query: 652 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 711
           NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780

Query: 712 KIANELKL 719
           KIANELKL
Sbjct: 781 KIANELKL 788


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 674/746 (90%), Positives = 677/746 (90%), Gaps = 61/746 (8%)

Query: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60

Query: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120

Query: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180

Query: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240

Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300

Query: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360

Query: 394 KVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 453
           KVQRSVSANPKQRRFSDQ AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV
Sbjct: 361 KVQRSVSANPKQRRFSDQ-AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 419

Query: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTA------ 507
           PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS        
Sbjct: 420 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 479

Query: 508 --------------------------------------------PQRVP----VASPSAH 519
                                                       P   P    VASPSAH
Sbjct: 480 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 539

Query: 520 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 579
           NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS
Sbjct: 540 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 599

Query: 580 IFSKFTSKFVRRNLSFRFAR------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 633
           IFSKFTSKFVRRNL+   ++      RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT
Sbjct: 600 IFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 659

Query: 634 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 693
           SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG
Sbjct: 660 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 719

Query: 694 VRFKRISGTSMAFKNIASKIANELKL 719
           VRFKRISGTSMAFKNIASKIANELKL
Sbjct: 720 VRFKRISGTSMAFKNIASKIANELKL 745


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  938 bits (2424), Expect = 0.0
 Identities = 517/801 (64%), Positives = 598/801 (74%), Gaps = 91/801 (11%)

Query: 3   SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54
           SARTPLPT+NERDTE  T   G+ +     +K SS+ N+ R RNS TSA DEQPHIGNYR
Sbjct: 2   SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61

Query: 55  LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114
           L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK
Sbjct: 62  LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121

Query: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174
           LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR
Sbjct: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181

Query: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
           DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW
Sbjct: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241

Query: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
           SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+
Sbjct: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301

Query: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354
           LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV
Sbjct: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361

Query: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407
           MATY+LLG K  E EG        +  + RPS+DL NS+  SP+H KVQRS+SAN KQRR
Sbjct: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421

Query: 408 FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGL 461
           FSD  AGP+IP + SY+K+ Q+N+ E+++ EE D++  RK  ST     +++ ASPL G 
Sbjct: 422 FSDH-AGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480

Query: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQ------------ 509
           ERKK++  PS N+V S  +   RN+ + ER +    ++QNGKDS+  +            
Sbjct: 481 ERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSS 539

Query: 510 ---RVPVASP----------------------------------------SAHNISSSGG 526
               VP A P                                        SAH+IS++  
Sbjct: 540 VASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTA-- 597

Query: 527 APDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGSIFS 582
            PDRT FPRG SSRSTFH  QL   R+++++ Y   PASPS      +  RRG S  I S
Sbjct: 598 TPDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTGIIS 654

Query: 583 KFTSKFVRRNLSFRFA--RRPHVVGSGGNDKE--KEEFREAKPRSLRFTWSMKTTSSMEP 638
           K TSKFVRR+ S   A  R      + G  KE  KEE +++KPRSLRFTWSMKTTSSM+P
Sbjct: 655 KITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDP 714

Query: 639 NEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKR 698
           N+MMREIRKVLDAN+C  E  E+++L C+HG    +  VQWEMEVCKLPRLSLNGVRFKR
Sbjct: 715 NDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKR 774

Query: 699 ISGTSMAFKNIASKIANELKL 719
           ISGTS+AFKNIASKIANELKL
Sbjct: 775 ISGTSIAFKNIASKIANELKL 795


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  920 bits (2378), Expect = 0.0
 Identities = 511/763 (66%), Positives = 584/763 (76%), Gaps = 57/763 (7%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----- 460
             AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G     
Sbjct: 421 H-AGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNP 478

Query: 461 -----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVP 512
                 ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR P
Sbjct: 479 NKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTP 537

Query: 513 VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-- 569
           VA  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H  
Sbjct: 538 VA--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEA 590

Query: 570 ---SQGRRGASGSIFSKFTSKFVRRNLSFRFARR--------PHVVGSGGN--DKEKEEF 616
              SQ R   S ++FSK TSK  RRN+SFRF +R            GS  N   ++K+E 
Sbjct: 591 TPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDEN 650

Query: 617 REAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDF 676
           +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ 
Sbjct: 651 KEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENL 710

Query: 677 VQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719
           VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 711 VQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  912 bits (2358), Expect = 0.0
 Identities = 507/755 (67%), Positives = 579/755 (76%), Gaps = 50/755 (6%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----- 460
             AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G     
Sbjct: 421 H-AGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNP 478

Query: 461 -----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVP 512
                 ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR P
Sbjct: 479 NKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTP 537

Query: 513 VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-- 569
           VA  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H  
Sbjct: 538 VA--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEA 590

Query: 570 ---SQGRRGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGN--DKEKEEFREAKPRSL 624
              SQ R   S ++FSK TSK  RR L   + R     GS  N   ++K+E +EAKPRSL
Sbjct: 591 TPLSQTRSRGSTNLFSKLTSKLTRR-LPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSL 649

Query: 625 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 684
           RFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVC
Sbjct: 650 RFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVC 709

Query: 685 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719
           KLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 710 KLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 744


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  905 bits (2339), Expect = 0.0
 Identities = 504/754 (66%), Positives = 576/754 (76%), Gaps = 63/754 (8%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----- 460
             AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G     
Sbjct: 421 H-AGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNP 478

Query: 461 -----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVP 512
                 ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR P
Sbjct: 479 NKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTP 537

Query: 513 VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-- 569
           VA  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H  
Sbjct: 538 VA--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEA 590

Query: 570 ---SQGRRGASGSIFSKFTSKFVR-RNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLR 625
              SQ R   S ++FSK TSK  R RN+S                ++K+E +EAKPRSLR
Sbjct: 591 TPLSQTRSRGSTNLFSKLTSKLTRSRNVS---------------AEQKDENKEAKPRSLR 635

Query: 626 FTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCK 685
           FTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCK
Sbjct: 636 FTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCK 695

Query: 686 LPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719
           LPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 696 LPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 729


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  902 bits (2332), Expect = 0.0
 Identities = 502/747 (67%), Positives = 573/747 (76%), Gaps = 65/747 (8%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAI 417
           YLLLG KSSE+         RPS+DL NS+  SP HKVQRSV ++ KQRR+SD  AGPAI
Sbjct: 361 YLLLGRKSSEV---------RPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDH-AGPAI 410

Query: 418 PTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LE 462
           P+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G           E
Sbjct: 411 PSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPE 469

Query: 463 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAH 519
           RKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H
Sbjct: 470 RKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STH 526

Query: 520 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGR 573
           +ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R
Sbjct: 527 SISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTR 581

Query: 574 RGASGSIFSKFTSKFVR-RNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKT 632
              S ++FSK TSK  R RN+S                ++K+E +EAKPRSLRFTWSMKT
Sbjct: 582 SRGSTNLFSKLTSKLTRSRNVS---------------AEQKDENKEAKPRSLRFTWSMKT 626

Query: 633 TSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLN 692
           TSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLN
Sbjct: 627 TSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLN 686

Query: 693 GVRFKRISGTSMAFKNIASKIANELKL 719
           GVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 687 GVRFKRISGTSIAFKNIASKIANELKL 713


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  642 bits (1655), Expect = 0.0
 Identities = 382/636 (60%), Positives = 447/636 (70%), Gaps = 58/636 (9%)

Query: 3   SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
           S+RT L   N+R+++   TLG     D  PS  S+S   R RNS  S  +EQPH+GNYRL
Sbjct: 2   SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61

Query: 56  LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
           L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 62  LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121

Query: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
           FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181

Query: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
           LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241

Query: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
           LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301

Query: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
           EQIMKD+W+N+G+E +ELKPY EP  D+ D +R E+MV MGYTREEI++SL  Q+YNEV 
Sbjct: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361

Query: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
           ATYLLLG K+ E  GD         + R  +D TN  SS+   SH K QRS S+   +QR
Sbjct: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420

Query: 407 RFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-------STAKVPASPLP 459
           R SD   GP+    +     T +  AE K   E+R  GRKAS       S    P+SP+ 
Sbjct: 421 RHSD-FCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLPPSSPMV 476

Query: 460 GL----------ERKKTTPTPSTNSVLSTSTNRS----RNSPLLERASLGQASIQNGKD- 504
                       ER+K + +   N   S  T R+       P  ER SL    + NGK+ 
Sbjct: 477 SSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSL----LPNGKEN 532

Query: 505 STAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV--- 561
           S+   RVP ASPS+H+++   G  +R+   RG + RSTFH GQ+R  R       GV   
Sbjct: 533 SSGTPRVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNG 590

Query: 562 TPASPS-GHS-----QGRRGASGSIFSKFTSKFVRR 591
            PASP+  H       GR   + ++F+K TSK  RR
Sbjct: 591 PPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRR 626


>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
           [Homo sapiens]
          Length = 659

 Score =  492 bits (1267), Expect = e-139
 Identities = 285/498 (57%), Positives = 353/498 (70%), Gaps = 46/498 (9%)

Query: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236

Query: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296

Query: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSK 425
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD  AGPAIP+  +Y K
Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDH-AGPAIPSVVAYPK 355

Query: 426 KTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LERKKTTPTP 470
           ++Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  P
Sbjct: 356 RSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVP 414

Query: 471 STNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHNISSSGGA 527
           S+N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+ISS+   
Sbjct: 415 SSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHSISSA-AT 470

Query: 528 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIF 581
           PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++F
Sbjct: 471 PDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLF 526

Query: 582 SKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 641
           SK TSK  RRN+SFRF +  +V     + ++K+E +EAKPRSLRFTWSMKTTSSM+P +M
Sbjct: 527 SKLTSKLTRRNMSFRFIKSRNV-----SAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 581

Query: 642 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 701
           MREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISG
Sbjct: 582 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 641

Query: 702 TSMAFKNIASKIANELKL 719
           TS+AFKNIASKIANELKL
Sbjct: 642 TSIAFKNIASKIANELKL 659



 Score =  281 bits (719), Expect = 1e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  382 bits (980), Expect = e-106
 Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           IG Y + +TIGKGNFA VK A H++T  +VA+KIIDKTQL+  +L+K+FREV+IMK+L H
Sbjct: 5   IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65  PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           +VD+WSLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST+CE+L++  L+L+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
           +KR ++EQI K +WM +G  D      +      K+ R+ +         M  MG  +E+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304

Query: 342 IQDSLVGQRYNEVMATYLLL 361
              SL    Y+   A Y LL
Sbjct: 305 TLQSLRSDAYDHYSAIYSLL 324


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  360 bits (925), Expect = 2e-99
 Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           +G Y + +T+GKGNFA VKLARH +T  +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I+KL++V+ET+  LY+V E+A  GE+FDYL ++G + E EAR KF QI+SAV+YCH  
Sbjct: 84  PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLK ENLLLD +M+IK+ADFGF N +  G  L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           ++D+WSLGV+LY LV GSLPFDG NL  LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263

Query: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
           ++R T+ QI + RWM                  Y   L DY D +   +M ++G  R+  
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322

Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
            +SL    YN   A Y LL      Y++++        +PRP S+DL+    P      Q
Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376

Query: 397 RSVSANP 403
             +S +P
Sbjct: 377 EGLSTDP 383


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  357 bits (916), Expect = 2e-98
 Identities = 201/437 (45%), Positives = 276/437 (63%), Gaps = 23/437 (5%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           +G Y +  T+GKGNFA VKL RH +T  EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 17  VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I+KL++V+ET+  LYLV EYA  GE+FDYL  HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77  PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLKAENLLLD +MNIKIADFGF N F  G  L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           ++D+WS+GV+LY LV G+LPFDG  L  LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
           SKR T+ QI + +WM +  E    +P + P     +P   E       LM S+G  +++ 
Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314

Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
            +SL  + YN   A Y LL      ++SS   E   D    +P   A+ T + A +    
Sbjct: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT---- 370

Query: 395 VQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 454
           V   V+ +    R    A  P      ++S       AE    EE+     K +     P
Sbjct: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430

Query: 455 ASPLPGLERKKTTPTPS 471
             P+  L RK     PS
Sbjct: 431 VPPV--LVRKGCQSLPS 445


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  295 bits (754), Expect = 1e-79
 Identities = 192/508 (37%), Positives = 274/508 (53%), Gaps = 47/508 (9%)

Query: 49  HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
           ++G YRL KT+GKG    VKL  H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++ 
Sbjct: 30  YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89

Query: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
           HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQIVSA+ +CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
             I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G+KYDG
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
              D+WS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+  + + 
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
           P KR +LEQI K  W   G HE D   P +EP P  +            DP   E M S+
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326

Query: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
           G    RE +   L  +  N E M  YLLL  K      +   L PR   D       SP 
Sbjct: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386

Query: 392 --SHKVQRSVSANPKQRRFSDQAAGPA-IPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 448
              H  +R    + +    +D   G + +PT  +      + +++  R      +G  +S
Sbjct: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE---MAQHSQRSRSVSGASTGLSSS 443

Query: 449 --STAKVPA---SPLPGL---ERKKTTPTPSTNSVLSTSTN-----------RSRNSPLL 489
             S+ + P    SP PG     R   +PT  T ++ S                +R++PL 
Sbjct: 444 PLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPL- 502

Query: 490 ERASLGQASIQNGKDSTAPQRVPVASPS 517
                G      G    +P   P ASP+
Sbjct: 503 -PGPPGSPRSSGGTPLHSPLHTPRASPT 529


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  288 bits (736), Expect = 2e-77
 Identities = 171/446 (38%), Positives = 248/446 (55%), Gaps = 20/446 (4%)

Query: 44  ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
           A    ++G YRL KT+GKG    VKL  H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 10  AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69

Query: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
           +K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQI+SA+
Sbjct: 70  LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129

Query: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
            +CH   I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G
Sbjct: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189

Query: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
           +KYDG + DVWS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+ 
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249

Query: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
            + ++ ++R TLE I K  W   G  + E       K  +  LP  +  DP   + M S+
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309

Query: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
           G  R+    +QD L  +   E M  +LLL  K      +   L PR   D       SP 
Sbjct: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368

Query: 393 HKVQRSVSANPKQRR---FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 449
             + R     P+++     S    G  +P   +      + + +  R      SG   S 
Sbjct: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424

Query: 450 TAKVPASPLPGLERKKTTPTPSTNSV 475
            +    +P P   R    PTP    V
Sbjct: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  273 bits (699), Expect = 3e-73
 Identities = 207/686 (30%), Positives = 334/686 (48%), Gaps = 64/686 (9%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69

Query: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129

Query: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308

Query: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 405
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366

Query: 406 RRF---------SDQAAGPAIPTSNSYSKK-TQSNNAENK--RPEEDRESGRKASSTAKV 453
                        D + G A P ++ ++K  T+SN  E+K   P   R    K  +   V
Sbjct: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENV 426

Query: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPV 513
             +P   ++ ++    P   + ++ + ++        R +   +  +N      P ++PV
Sbjct: 427 -YTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTT-PSKARNQCLKETPIKIPV 484

Query: 514 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGR 573
            S     + +   +P+R                + R V    N  +          +  R
Sbjct: 485 NSTGTDKLMTGVISPER----------------RCRSVELDLNQAH-------MEETPKR 521

Query: 574 RGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 633
           +GA   +F       + R L         V+      K K   R+  PR L+  +++ TT
Sbjct: 522 KGA--KVFGS-----LERGLD-------KVITVLTRSKRKGSARDG-PRRLKLHYNVTTT 566

Query: 634 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 693
             + P++++ EI  +L        + + Y L C   +   +  +Q+E+EVC+L +  + G
Sbjct: 567 RLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVG 625

Query: 694 VRFKRISGTSMAFKNIASKIANELKL 719
           +R +R+ G +  +K +   I +  K+
Sbjct: 626 IRRQRLKGDAWVYKRLVEDILSSCKV 651


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  271 bits (693), Expect = 2e-72
 Identities = 166/467 (35%), Positives = 251/467 (53%), Gaps = 51/467 (10%)

Query: 51  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
                 +  L++++ P    +   SV    + +   D A        AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 467
           K  ++  +      +  EED E  +  S + +V     P +  + T+
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  271 bits (693), Expect = 2e-72
 Identities = 166/467 (35%), Positives = 251/467 (53%), Gaps = 51/467 (10%)

Query: 51  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
                 +  L++++ P    +   SV    + +   D A        AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 467
           K  ++  +      +  EED E  +  S + +V     P +  + T+
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  266 bits (680), Expect = 5e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181

Query: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241

Query: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296

Query: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361
                 T  E+ +SL  G   +++   Y L+
Sbjct: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  265 bits (676), Expect = 1e-70
 Identities = 152/386 (39%), Positives = 227/386 (58%), Gaps = 23/386 (5%)

Query: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131

Query: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191

Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251

Query: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306

Query: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366

Query: 386 SSAPSPSHKVQRSVSANPKQRRFSDQ 411
            + P P  +V   V+  P+ R   D+
Sbjct: 367 LTRPHP-ERVPFLVAETPRARHTLDE 391


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  255 bits (652), Expect = 9e-68
 Identities = 128/298 (42%), Positives = 196/298 (65%), Gaps = 8/298 (2%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           IG YR+   IG GNF++VKL  H LT ++VA+KI+DKT+L+  + + L RE+  M+ L+H
Sbjct: 71  IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           PNI++L+EV+ET   L+LVMEYA GGE+F  +   G++ E E++  F QIVSAV++ H+ 
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            I+HRDLKAEN+   ++  +K+ DFGFS     G  L+TFCGSPPYAAPELF+ + Y G 
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
            VD+W+LGV+LY +V+G++PF  + + +L++ +L G Y +P ++S  C  L++  L   P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYK-DPRRTELMVSMGYTREEIQDSL 346
           ++R  ++ IM D WM       +  PY  PL  ++ DP+      ++     E++ +L
Sbjct: 311 TERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTL 361


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  254 bits (650), Expect = 1e-67
 Identities = 152/401 (37%), Positives = 227/401 (56%), Gaps = 38/401 (9%)

Query: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR          
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131

Query: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
                + EKE+R  F+QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  +
Sbjct: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191

Query: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
            G  L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L ++
Sbjct: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251

Query: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
           +  G +  P Y++    +LLK  L ++P KR T++ I +  W        +L  Y+ P  
Sbjct: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306

Query: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
           P Y      D    E+      + EE+   L  + + + +A   +L++  +    E    
Sbjct: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366

Query: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ 411
            L   P     D  + + P P  +V   V+  P+ R   D+
Sbjct: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDE 406


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  253 bits (647), Expect = 3e-67
 Identities = 172/508 (33%), Positives = 258/508 (50%), Gaps = 82/508 (16%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
           Y L +T+GKG + KVK A    +G+ VA+K I K ++ +   +  + RE+ IM  LNHP+
Sbjct: 55  YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114

Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
           I+ ++EV E +  + ++MEYAS GE++DY+    R+ E+E R  FRQIVSAV YCH+  +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174

Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
           VHRDLK EN+LLD + NIKIADFG SN +     L TFCGSP YA+PE+  G+ Y GPEV
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
           D W+LGV+LYTLV G++PFDG + K L  ++  G+YR P   S D   L++  L++NP +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293

Query: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
           R T+E I    W+N G++        + L D + P                         
Sbjct: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326

Query: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
             ++A  +   ++S+ L+ DT        A +   + P+ S  +   QRS+  + K+  F
Sbjct: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377

Query: 409 SDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------ 452
           + Q+   A+P S S     +      KR   +  S          G    ST K      
Sbjct: 378 A-QSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLC 436

Query: 453 -----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASL 494
                +P+SP   +PG    K + T     +L           +S  RS +S LL+   +
Sbjct: 437 RTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDV 496

Query: 495 GQASIQNGKDSTAPQRVPVASPSAHNIS 522
             +SI       +P     A  ++H++S
Sbjct: 497 MGSSI------PSPSPPDPARVTSHSLS 518


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  253 bits (646), Expect = 4e-67
 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
           Y  L+T+GKG + KVK AR   +G+ VA+K I K ++ +   L  + RE+ IM  LNHP+
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
           I+ + EV E    + +VMEYAS G+++DY+    ++ E+EAR  FRQIVSAV YCHQ  +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
           VHRDLK EN+LLDA+ NIKIADFG SN +  G  L TFCGSP YA+PE+  GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
           D WSLGV+LY LV G++PFDG + K L +++  G YR P   S  C  L++  L++NP++
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290

Query: 292 RGTLEQIMKDRWMNVGH 308
           R TLE +    W+N G+
Sbjct: 291 RATLEDVASHWWVNWGY 307


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  220 bits (561), Expect = 3e-57
 Identities = 125/335 (37%), Positives = 200/335 (59%), Gaps = 16/335 (4%)

Query: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110

Query: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170

Query: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230

Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289

Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349

Query: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK 364
            +   +GY   ++ ++++  R   ++A Y LL  K
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKK 384


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  191 bits (485), Expect = 2e-48
 Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
           Y L   +G+G++AKVK A        VA+KIID+ +  +  L+K   RE+ I+ +LNH +
Sbjct: 12  YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71

Query: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
           I+K +E+ ET    +Y+VME A  G++ + +   G + E EAR KF Q+  A++YCH   
Sbjct: 72  IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131

Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
           +VHRDLK +NLLLD D NIK++DF FS      +        TFCGSP YAAPE+ QG  
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191

Query: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
           Y     D+WSLGVILY +V GS+P+D  N+K++    ++ ++R+ F    +++ +C++L+
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249

Query: 282 KKFLILNPSKRGTLEQIMKDRWM 304
              L  + ++R  +++I+   WM
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272


>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
          Length = 268

 Score =  186 bits (471), Expect = 9e-47
 Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
           Y+L KTIG+G ++KVK A      ++VA+K+IDK       +Q+   RE++I++ L+H N
Sbjct: 10  YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69

Query: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
           I++++E++E+ +  + LVME A GG+VFD ++  G + E  A+A FRQ+V A++YCH   
Sbjct: 70  IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129

Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
           + HRDLK EN LL    N+K+ DFGF+      ++    TFCGS  YAAPE+ QG  +D 
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
            + DVWS+GV+LY ++  SLPFD  ++ ++  +  +G  +     +S DC++LLK+ L  
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248

Query: 288 NPSKRGTLEQIMKDRWM 304
           +   R ++E++    W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265


>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
          Length = 358

 Score =  183 bits (465), Expect = 4e-46
 Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)

Query: 59  IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
           +GKG++AKVK A        VAVKIID+ +  +  +++   RE+ I+  +NH +I+K +E
Sbjct: 18  LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77

Query: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
           + ET +  +Y++ME    G++ +++   G + E  AR  FRQ+ SAV+YCH   IVHRDL
Sbjct: 78  IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137

Query: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
           K ENLLLD D NIK++DFGFS      +        TFCGS  YAAPE+ Q   Y     
Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
           D+WSLGVILY +V GS+P+D  +++++    ++ ++R+ F     ++ +C++L+ + L  
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255

Query: 288 NPSKRGTLEQIMKDRWM 304
           + S+R  +++I+   W+
Sbjct: 256 DVSQRLHIDEILSHSWL 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,035,958
Number of Sequences: 37866
Number of extensions: 1344760
Number of successful extensions: 7773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 742
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 4499
Number of HSP's gapped (non-prelim): 1798
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.