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Search of human proteins with 254028234
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|254028234 MAP/microtubule affinity-regulating kinase 2
isoform d [Homo sapiens]
(788 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 1568 0.0
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 1471 0.0
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 1385 0.0
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 1377 0.0
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 1350 0.0
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 1002 0.0
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 905 0.0
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 885 0.0
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 879 0.0
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 876 0.0
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 632 0.0
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor... 465 e-131
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 382 e-106
gi|116256471 SNF1-like kinase [Homo sapiens] 360 2e-99
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 357 2e-98
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 293 3e-79
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 288 2e-77
gi|156105707 SNF related kinase [Homo sapiens] 281 1e-75
gi|156105705 SNF related kinase [Homo sapiens] 281 1e-75
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 266 6e-71
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 265 2e-70
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 255 1e-67
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 254 2e-67
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 254 2e-67
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 253 5e-67
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 252 8e-67
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 224 2e-58
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 191 2e-48
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 186 9e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 183 5e-46
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 1568 bits (4059), Expect = 0.0
Identities = 788/788 (100%), Positives = 788/788 (100%)
Query: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
Query: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
Query: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540
NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540
Query: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600
NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600
Query: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE
Sbjct: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660
Query: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720
Query: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780
Query: 781 KIANELKL 788
KIANELKL
Sbjct: 781 KIANELKL 788
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 1471 bits (3808), Expect = 0.0
Identities = 745/755 (98%), Positives = 745/755 (98%), Gaps = 10/755 (1%)
Query: 34 MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93
MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 1 MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
Query: 94 LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153
LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 61 LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
Query: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213
AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
Query: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333
STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
Query: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393
SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
Query: 394 KVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 453
KVQRSVSANPKQRRFSDQ AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV
Sbjct: 361 KVQRSVSANPKQRRFSDQ-AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 419
Query: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 513
PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA
Sbjct: 420 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 479
Query: 514 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 573
STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH
Sbjct: 480 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 539
Query: 574 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 633
NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS
Sbjct: 540 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 599
Query: 634 IFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 693
IFSKFTSKFV RRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL
Sbjct: 600 IFSKFTSKFV---------RRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 650
Query: 694 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 753
RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC
Sbjct: 651 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 710
Query: 754 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788
KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Sbjct: 711 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 1385 bits (3584), Expect = 0.0
Identities = 718/788 (91%), Positives = 718/788 (91%), Gaps = 64/788 (8%)
Query: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
Query: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419
Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479
Query: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540
NRSRNSPLLERASLGQASIQNGKDS T P R AS SA
Sbjct: 480 NRSRNSPLLERASLGQASIQNGKDS-TAP-QRVPVASPSA-------------------- 517
Query: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600
HNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 518 --------------------------------HNISSSGGAPDRTNFPRGVSSRSTFHAG 545
Query: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV RRNLNEPE
Sbjct: 546 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV---------RRNLNEPE 596
Query: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 597 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 656
Query: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 657 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 716
Query: 781 KIANELKL 788
KIANELKL
Sbjct: 717 KIANELKL 724
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 1377 bits (3563), Expect = 0.0
Identities = 713/788 (90%), Positives = 713/788 (90%), Gaps = 69/788 (8%)
Query: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
Query: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
Query: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540
NRSRNSPLLERASLGQASIQNGKDS T P R AS SA
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDS-TAP-QRVPVASPSA-------------------- 518
Query: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600
HNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 519 --------------------------------HNISSSGGAPDRTNFPRGVSSRSTFHAG 546
Query: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR
Sbjct: 547 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR------- 599
Query: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720
RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 600 --------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 651
Query: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 652 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 711
Query: 781 KIANELKL 788
KIANELKL
Sbjct: 712 KIANELKL 719
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 1350 bits (3493), Expect = 0.0
Identities = 703/788 (89%), Positives = 703/788 (89%), Gaps = 79/788 (10%)
Query: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
Query: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419
Query: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479
Query: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540
NRSRNSPLLERASLGQASIQNGKDS T P R AS SA
Sbjct: 480 NRSRNSPLLERASLGQASIQNGKDS-TAP-QRVPVASPSA-------------------- 517
Query: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600
HNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 518 --------------------------------HNISSSGGAPDRTNFPRGVSSRSTFHAG 545
Query: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVR
Sbjct: 546 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVR---------------- 589
Query: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720
RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 590 --------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 641
Query: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 642 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 701
Query: 781 KIANELKL 788
KIANELKL
Sbjct: 702 KIANELKL 709
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 1002 bits (2591), Expect = 0.0
Identities = 546/815 (66%), Positives = 636/815 (78%), Gaps = 50/815 (6%)
Query: 3 SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54
SARTPLPT+NERDTE T G+ + +K SS+ N+ R RNS TSA DEQPHIGNYR
Sbjct: 2 SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61
Query: 55 LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114
L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK
Sbjct: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121
Query: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174
LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR
Sbjct: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181
Query: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW
Sbjct: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241
Query: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+
Sbjct: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301
Query: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354
LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV
Sbjct: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361
Query: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407
MATY+LLG K E EG + + RPS+DL NS+ SP+H KVQRS+SAN KQRR
Sbjct: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421
Query: 408 FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGL 461
FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++ RK ST +++ ASPL G
Sbjct: 422 FSDH-AGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP 480
Query: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASA--- 518
ERKK++ PS N+V S + RN+ + ER + ++QNGKDS S +S +SA
Sbjct: 481 ERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSS 539
Query: 519 -SAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISS 577
++AV +ARPR HQKSMS S HP K + LP + E RP T QRVP ASPSAH+IS+
Sbjct: 540 VASAVPSARPR-HQKSMSTSGHPIKVT-LPTIKDGSEAYRPGTT-QRVPAASPSAHSIST 596
Query: 578 SGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGS 633
+ PDRT FPRG SSRSTFH QL R+++++ Y PASPS + RRG S
Sbjct: 597 A--TPDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTG 651
Query: 634 IFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 693
I SK TSKFVRR+ S E E+ R +T R +++KEE +++KPRSL
Sbjct: 652 IISKITSKFVRRDPS---------EGEASGRTDTSRS--TSGEPKERDKEEGKDSKPRSL 700
Query: 694 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 753
RFTWSMKTTSSM+PN+MMREIRKVLDAN+C E E+++L C+HG + VQWEMEVC
Sbjct: 701 RFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVC 760
Query: 754 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788
KLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 761 KLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 905 bits (2338), Expect = 0.0
Identities = 507/805 (62%), Positives = 584/805 (72%), Gaps = 72/805 (8%)
Query: 3 SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
S RTPLPT+NERDTE T H D + S R RNS A+ ADEQPHIGNYRLLK
Sbjct: 2 STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
Query: 58 TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61 TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
IMKDRW+N GHE+DELKP+VEP D D +R ++MV MGY++EEIQ+SL +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
YLLLG KSSEL+ + K RPS+DL NS+ SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP 470
A GPAIP+ +Y K++Q++ A++ +ED S RK+S +A P
Sbjct: 421 HA-GPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA---------- 468
Query: 471 STNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQ 529
SP+L AS +A I K S T+P S + S R+
Sbjct: 469 ---------------SPMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRR 505
Query: 530 HQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPR 589
+ S ++ S + + N +P QR PVAS H+ISS+ PDR FPR
Sbjct: 506 NTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPR 557
Query: 590 GVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFV 643
G +SRSTFH Q R+++ Y PASPS H SQ R S ++FSK TSK
Sbjct: 558 GTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 613
Query: 644 RRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 703
RRN+SFRF +R E E R E +V + ++K+E +EAKPRSLRFTWSMKTTS
Sbjct: 614 RRNMSFRFIKRLPTEYERNGRYEGSSRNV-----SAEQKDENKEAKPRSLRFTWSMKTTS 668
Query: 704 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 763
SM+P +MMREIRKVLDAN+C E E+++L C+HG E+ VQWEMEVCKLPRLSLNGV
Sbjct: 669 SMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGV 728
Query: 764 RFKRISGTSMAFKNIASKIANELKL 788
RFKRISGTS+AFKNIASKIANELKL
Sbjct: 729 RFKRISGTSIAFKNIASKIANELKL 753
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 885 bits (2288), Expect = 0.0
Identities = 500/805 (62%), Positives = 577/805 (71%), Gaps = 81/805 (10%)
Query: 3 SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
S RTPLPT+NERDTE T H D + S R RNS A+ ADEQPHIGNYRLLK
Sbjct: 2 STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
Query: 58 TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61 TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
IMKDRW+N GHE+DELKP+VEP D D +R ++MV MGY++EEIQ+SL +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
YLLLG KSSEL+ + K RPS+DL NS+ SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP 470
A GPAIP+ +Y K++Q++ A++ +ED S RK+S +A P
Sbjct: 421 HA-GPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA---------- 468
Query: 471 STNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQ 529
SP+L AS +A I K S T+P S + S R+
Sbjct: 469 ---------------SPMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRR 505
Query: 530 HQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPR 589
+ S ++ S + + N +P QR PVAS H+ISS+ PDR FPR
Sbjct: 506 NTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPR 557
Query: 590 GVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFV 643
G +SRSTFH Q R+++ Y PASPS H SQ R S ++FSK TSK
Sbjct: 558 GTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 613
Query: 644 RRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 703
RR L + R E S++ + ++K+E +EAKPRSLRFTWSMKTTS
Sbjct: 614 RR-LPTEYERNGRYEGSSRNV-------------SAEQKDENKEAKPRSLRFTWSMKTTS 659
Query: 704 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 763
SM+P +MMREIRKVLDAN+C E E+++L C+HG E+ VQWEMEVCKLPRLSLNGV
Sbjct: 660 SMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGV 719
Query: 764 RFKRISGTSMAFKNIASKIANELKL 788
RFKRISGTS+AFKNIASKIANELKL
Sbjct: 720 RFKRISGTSIAFKNIASKIANELKL 744
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 879 bits (2270), Expect = 0.0
Identities = 498/806 (61%), Positives = 572/806 (70%), Gaps = 98/806 (12%)
Query: 3 SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
S RTPLPT+NERDTE T H D + S R RNS A+ ADEQPHIGNYRLLK
Sbjct: 2 STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
Query: 58 TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61 TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
IMKDRW+N GHE+DELKP+VEP D D +R ++MV MGY++EEIQ+SL +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
YLLLG KSSEL+ + K RPS+DL NS+ SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
Query: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP 470
A GPAIP+ +Y K++Q++ A++ +ED S RK+S +A P
Sbjct: 421 HA-GPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA---------- 468
Query: 471 STNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQ 529
SP+L AS +A I K S T+P S + S R+
Sbjct: 469 ---------------SPMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRR 505
Query: 530 HQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPR 589
+ S ++ S + + N +P QR PVAS H+ISS+ PDR FPR
Sbjct: 506 NTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPR 557
Query: 590 GVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFV 643
G +SRSTFH Q R+++ Y PASPS H SQ R S ++FSK TSK
Sbjct: 558 GTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 613
Query: 644 R-RNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 702
R RN+S ++K+E +EAKPRSLRFTWSMKTT
Sbjct: 614 RSRNVS------------------------------AEQKDENKEAKPRSLRFTWSMKTT 643
Query: 703 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 762
SSM+P +MMREIRKVLDAN+C E E+++L C+HG E+ VQWEMEVCKLPRLSLNG
Sbjct: 644 SSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNG 703
Query: 763 VRFKRISGTSMAFKNIASKIANELKL 788
VRFKRISGTS+AFKNIASKIANELKL
Sbjct: 704 VRFKRISGTSIAFKNIASKIANELKL 729
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 876 bits (2263), Expect = 0.0
Identities = 496/799 (62%), Positives = 569/799 (71%), Gaps = 100/799 (12%)
Query: 3 SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
S RTPLPT+NERDTE T H D + S R RNS A+ ADEQPHIGNYRLLK
Sbjct: 2 STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
Query: 58 TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61 TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
IMKDRW+N GHE+DELKP+VEP D D +R ++MV MGY++EEIQ+SL +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
Query: 358 YLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAI 417
YLLLG KSSE+ RPS+DL NS+ SP HKVQRSV ++ KQRR+SD A GPAI
Sbjct: 361 YLLLGRKSSEV---------RPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHA-GPAI 410
Query: 418 PTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLS 477
P+ +Y K++Q++ A++ +ED S RK+S +A P
Sbjct: 411 PSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA----------------- 452
Query: 478 TSTNRSRNSPLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSA 536
SP+L AS +A I K S T+P S + S R++ S
Sbjct: 453 --------SPMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRRNTYVCSE 496
Query: 537 SVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRST 596
++ S + + N +P QR PVAS H+ISS+ PDR FPRG +SRST
Sbjct: 497 RTTADRHSVIQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPRGTASRST 548
Query: 597 FHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFVR-RNLSF 649
FH Q R+++ Y PASPS H SQ R S ++FSK TSK R RN+S
Sbjct: 549 FHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVS- 603
Query: 650 RFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNE 709
++K+E +EAKPRSLRFTWSMKTTSSM+P +
Sbjct: 604 -----------------------------AEQKDENKEAKPRSLRFTWSMKTTSSMDPGD 634
Query: 710 MMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRIS 769
MMREIRKVLDAN+C E E+++L C+HG E+ VQWEMEVCKLPRLSLNGVRFKRIS
Sbjct: 635 MMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRIS 694
Query: 770 GTSMAFKNIASKIANELKL 788
GTS+AFKNIASKIANELKL
Sbjct: 695 GTSIAFKNIASKIANELKL 713
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 632 bits (1629), Expect = 0.0
Identities = 387/683 (56%), Positives = 455/683 (66%), Gaps = 74/683 (10%)
Query: 3 SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
S+RT L N+R+++ TLG D PS S+S R RNS S +EQPH+GNYRL
Sbjct: 2 SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61
Query: 56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 62 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
Query: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
Query: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
Query: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301
Query: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
EQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV MGYTREEI++SL Q+YNEV
Sbjct: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361
Query: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
ATYLLLG K+ E GD + R +D TN SS+ SH K QRS S+ +QR
Sbjct: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
Query: 407 RFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-STAKVPASPLPGLERKK 465
R SD GP+ + T + AE K E+R GRKAS STA + LP
Sbjct: 421 RHSD-FCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLP------ 470
Query: 466 TTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGS--RASTASASAAVS 523
PS+ V S P + KDS + P + + + V
Sbjct: 471 ----PSSPMVSSAHNPNKAEIP------------ERRKDSTSTPNNLPPSMMTRRNTYVC 514
Query: 524 AARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPD 583
RP + S+ LP + N S+ RVP ASPS+H+++ G +
Sbjct: 515 TERPGAERPSL-----------LPNGKEN------SSGTPRVPPASPSSHSLAPPSG--E 555
Query: 584 RTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---TPASPS-GHS-----QGRRGASGSI 634
R+ RG + RSTFH GQ+R R GV PASP+ H GR + ++
Sbjct: 556 RSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNL 615
Query: 635 FSKFTSKFVRRNLSFRFARRNLN 657
F+K TSK RR R+N N
Sbjct: 616 FTKLTSKLTRRVTLDPSKRQNSN 638
>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
[Homo sapiens]
Length = 659
Score = 465 bits (1196), Expect = e-131
Identities = 280/551 (50%), Positives = 350/551 (63%), Gaps = 83/551 (15%)
Query: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312
++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236
Query: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372
LKP+VEP D D +R ++MV MGY++EEIQ+SL +Y+E+ ATYLLLG KSSEL+
Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296
Query: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSK 425
+ K RPS+DL NS+ SP HKVQRSV ++ KQRR+SD A GPAIP+ +Y K
Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHA-GPAIPSVVAYPK 355
Query: 426 KTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRN 485
++Q++ A++ +ED S RK+S +A P
Sbjct: 356 RSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA------------------------- 389
Query: 486 SPLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKAS 544
SP+L AS +A I K S T+P S + S R++ S ++ S
Sbjct: 390 SPMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRRNTYVCSERTTADRHS 441
Query: 545 GLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQ 604
+ + N +P QR PVAS H+ISS+ PDR FPRG +SRSTFH Q
Sbjct: 442 VIQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPRGTASRSTFHG----Q 489
Query: 605 VRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFVRRNLSFRFAR-RNLN 657
R+++ Y PASPS H SQ R S ++FSK TSK RRN+SFRF + RN++
Sbjct: 490 PRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVS 549
Query: 658 EPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKV 717
++K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKV
Sbjct: 550 A---------------------EQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKV 588
Query: 718 LDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKN 777
LDAN+C E E+++L C+HG E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKN
Sbjct: 589 LDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN 648
Query: 778 IASKIANELKL 788
IASKIANELKL
Sbjct: 649 IASKIANELKL 659
Score = 281 bits (719), Expect = 2e-75
Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)
Query: 3 SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
S RTPLPT+NERDTE T H D + S R RNS A+ ADEQPHIGNYRLLK
Sbjct: 2 STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
Query: 58 TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61 TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 382 bits (980), Expect = e-106
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
Query: 342 IQDSLVGQRYNEVMATYLLL 361
SL Y+ A Y LL
Sbjct: 305 TLQSLRSDAYDHYSAIYSLL 324
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
Query: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
Query: 397 RSVSANP 403
+S +P
Sbjct: 377 EGLSTDP 383
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 357 bits (916), Expect = 2e-98
Identities = 201/437 (45%), Positives = 276/437 (63%), Gaps = 23/437 (5%)
Query: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT---- 370
Query: 395 VQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 454
V V+ + R A P ++S AE EE+ K + P
Sbjct: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430
Query: 455 ASPLPGLERKKTTPTPS 471
P+ L RK PS
Sbjct: 431 VPPV--LVRKGCQSLPS 445
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 293 bits (751), Expect = 3e-79
Identities = 182/457 (39%), Positives = 259/457 (56%), Gaps = 34/457 (7%)
Query: 49 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
Query: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
Query: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
Query: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
Query: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
Query: 392 --SHKVQRSVSANPKQRRFSDQAAGPA-IPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 448
H +R + + +D G + +PT + + +++ R +G +S
Sbjct: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE---MAQHSQRSRSVSGASTGLSSS 443
Query: 449 --STAKVPA---SPLPGL---ERKKTTPTPSTNSVLS 477
S+ + P SP PG R +PT T ++ S
Sbjct: 444 PLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 288 bits (736), Expect = 2e-77
Identities = 171/446 (38%), Positives = 248/446 (55%), Gaps = 20/446 (4%)
Query: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
Query: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
Query: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
Query: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
Query: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
Query: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
Query: 393 HKVQRSVSANPKQRR---FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 449
+ R P+++ S G +P + + + + R SG S
Sbjct: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
Query: 450 TAKVPASPLPGLERKKTTPTPSTNSV 475
+ +P P R PTP V
Sbjct: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 281 bits (720), Expect = 1e-75
Identities = 202/608 (33%), Positives = 300/608 (49%), Gaps = 73/608 (12%)
Query: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
I ++L RYN + ATY LL + E E T + P
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
+ L++++ P + SV + + D A AGPA+ T S
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
Query: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 478
K ++ + + EED E + S + +V P + + T+ P N +
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
Query: 479 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 527
+ P L R AS G + + GS S++ S S +R
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552
Query: 528 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 578
R + S + S H +S PP +PS A V ASPS +N S S
Sbjct: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612
Query: 579 GGAPDRTN 586
GG P T+
Sbjct: 613 GGNPTNTS 620
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 281 bits (720), Expect = 1e-75
Identities = 202/608 (33%), Positives = 300/608 (49%), Gaps = 73/608 (12%)
Query: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ + LF+EVR MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
NIV+L+EVI+T+ LYL++E GG++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
+VHRDLK EN++ + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
P VD+WSLGVIL+ LV G PF N E ++ KY +P ++S +C++L+ + L +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
P +R +LE+I W+ G + Y PL YK+ E +++ R+
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
I ++L RYN + ATY LL + E E T + P
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA--------AGPAIPTSNSYSK 425
+ L++++ P + SV + + D A AGPA+ T S
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
Query: 426 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 478
K ++ + + EED E + S + +V P + + T+ P N +
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
Query: 479 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 527
+ P L R AS G + + GS S++ S S +R
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552
Query: 528 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 578
R + S + S H +S PP +PS A V ASPS +N S S
Sbjct: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612
Query: 579 GGAPDRTN 586
GG P T+
Sbjct: 613 GGNPTNTS 620
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 266 bits (680), Expect = 6e-71
Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)
Query: 44 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97
A++Q H IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ S + K+
Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
Query: 98 FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157
RE++ +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+
Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
Query: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
QI+SAV YCH+ +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
Query: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
Query: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331
LL L ++P KR T++ I + W +L Y+ P P Y D E+
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
Query: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361
T E+ +SL G +++ Y L+
Sbjct: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 265 bits (676), Expect = 2e-70
Identities = 152/386 (39%), Positives = 227/386 (58%), Gaps = 23/386 (5%)
Query: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
Query: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR+ EKE+R F
Sbjct: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
Query: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216
+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YA
Sbjct: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276
APE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++ G + P Y++
Sbjct: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
Query: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330
+LLK L ++P KR T++ I + W +L Y+ P P Y D E
Sbjct: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
Query: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385
+ + EE+ L + + + +A +L++ + E L P D +
Sbjct: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
Query: 386 SSAPSPSHKVQRSVSANPKQRRFSDQ 411
+ P P +V V+ P+ R D+
Sbjct: 367 LTRPHP-ERVPFLVAETPRARHTLDE 391
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 255 bits (652), Expect = 1e-67
Identities = 128/298 (42%), Positives = 196/298 (65%), Gaps = 8/298 (2%)
Query: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
IG YR+ IG GNF++VKL H LT ++VA+KI+DKT+L+ + + L RE+ M+ L+H
Sbjct: 71 IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130
Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
PNI++L+EV+ET L+LVMEYA GGE+F + G++ E E++ F QIVSAV++ H+
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190
Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
I+HRDLKAEN+ ++ +K+ DFGFS G L+TFCGSPPYAAPELF+ + Y G
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250
Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
VD+W+LGV+LY +V+G++PF + + +L++ +L G Y +P ++S C L++ L P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310
Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYK-DPRRTELMVSMGYTREEIQDSL 346
++R ++ IM D WM + PY PL ++ DP+ ++ E++ +L
Sbjct: 311 TERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTL 361
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 254 bits (650), Expect = 2e-67
Identities = 152/401 (37%), Positives = 227/401 (56%), Gaps = 38/401 (9%)
Query: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
Query: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
Query: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
Query: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
Query: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
Query: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
Query: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ 411
L P D + + P P +V V+ P+ R D+
Sbjct: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDE 406
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 254 bits (649), Expect = 2e-67
Identities = 193/606 (31%), Positives = 288/606 (47%), Gaps = 91/606 (15%)
Query: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
Query: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
R T+E I W+N G++ + L D + P
Sbjct: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
Query: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
Query: 409 SDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------ 452
+ Q+ A+P S S + KR + S G ST K
Sbjct: 378 A-QSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLC 436
Query: 453 -----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASL 494
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 437 RTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDV 496
Query: 495 GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSA-SVHPNKASGLPPTESNC 553
+SI + P A S S + +H SA ++ P S PT +
Sbjct: 497 MGSSIPS-----PSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESL 551
Query: 554 EVP--------RPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQV 605
P R + P V ++ S + S + N P RS A Q+
Sbjct: 552 SEPGVPAEGLSRSYSRPSSV-ISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQI 610
Query: 606 RDQQNL 611
+D + L
Sbjct: 611 QDFEGL 616
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 253 bits (646), Expect = 5e-67
Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%)
Query: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+
Sbjct: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 292 RGTLEQIMKDRWMNVGH 308
R TLE + W+N G+
Sbjct: 291 RATLEDVASHWWVNWGY 307
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 252 bits (644), Expect = 8e-67
Identities = 162/437 (37%), Positives = 237/437 (54%), Gaps = 33/437 (7%)
Query: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Y L +TIG G FAKVKLA HILTG+ VA+KI+DK L S L ++ E+ +K L H +I
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
Query: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172
+L+ V+ET +++V+EY GGE+FDY+++ R+ E+E R FRQIVSAV Y H +
Sbjct: 70 CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
Query: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229
HRDLK ENLL D +K+ DFG + GNK L T CGS YAAPEL QGK Y G
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
E DVWS+G++LY L+ G LPFD N+ L ++++RGKY +P ++S LL++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349
KR +++ ++ W+ + P D TEL V R+ ++D +
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
Query: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 405
+Y+ + ATYLLL K + G + L+ + S+ P K V+A+ K
Sbjct: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366
Query: 406 RRF---------SDQAAGPAIPTSNSYSKK-TQSNNAENKRPEEDRESGRKASSTAKVPA 455
D + G A P ++ ++K T+SN E+K S T +
Sbjct: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESK------------SLTPALCR 414
Query: 456 SPLPGLERKKTTPTPST 472
+P L+ K+ TP +
Sbjct: 415 TPANKLKNKENVYTPKS 431
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/109 (25%), Positives = 57/109 (52%), Gaps = 2/109 (1%)
Query: 680 KEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGT 739
K K R+ PR L+ +++ TT + P++++ EI +L + + Y L C +
Sbjct: 545 KRKGSARDG-PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQS 602
Query: 740 PGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788
+ +Q+E+EVC+L + + G+R +R+ G + +K + I + K+
Sbjct: 603 DFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 224 bits (571), Expect = 2e-58
Identities = 178/620 (28%), Positives = 288/620 (46%), Gaps = 88/620 (14%)
Query: 45 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
Query: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
Query: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
Query: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK-------SSELEGDTITLKPRPSAD 382
+ +GY ++ ++++ R ++A Y LL K S+++ D++ K R
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQ-DSLCYKTR-LYQ 407
Query: 383 LTNSSAPSPSHKVQ-----RSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRP 437
+ AP S++ R + + Q + + +SKK N +K+P
Sbjct: 408 IEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQP 467
Query: 438 E--------------EDRESGRK-----------------------ASSTAKVPASPLPG 460
+DR++ + ASS+ + P P
Sbjct: 468 SGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPR 527
Query: 461 LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTMPG 510
R P P ST + +L+ ++ S + L P
Sbjct: 528 TPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPV 587
Query: 511 SRASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPSTAP 562
S A S+ +S P + +HP S PP E C P PS P
Sbjct: 588 SLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGP 647
Query: 563 QRVPVASPSAHNISSSGGAP 582
+ P+ SP+ + S G P
Sbjct: 648 MQ-PLGSPNC--VKSRGRFP 664
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 191 bits (485), Expect = 2e-48
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Query: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
Query: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Query: 282 KKFLILNPSKRGTLEQIMKDRWM 304
L + ++R +++I+ WM
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 186 bits (471), Expect = 9e-47
Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Y+L KTIG+G ++KVK A ++VA+K+IDK +Q+ RE++I++ L+H N
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
I++++E++E+ + + LVME A GG+VFD ++ G + E A+A FRQ+V A++YCH
Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
+ HRDLK EN LL N+K+ DFGF+ ++ TFCGS YAAPE+ QG +D
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
+ DVWS+GV+LY ++ SLPFD ++ ++ + +G + +S DC++LLK+ L
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
Query: 288 NPSKRGTLEQIMKDRWM 304
+ R ++E++ W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 183 bits (465), Expect = 5e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
Query: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
Query: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
Query: 288 NPSKRGTLEQIMKDRWM 304
+ S+R +++I+ W+
Sbjct: 256 DVSQRLHIDEILSHSWL 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,977,851
Number of Sequences: 37866
Number of extensions: 1504129
Number of successful extensions: 9566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 770
Number of HSP's successfully gapped in prelim test: 601
Number of HSP's that attempted gapping in prelim test: 5775
Number of HSP's gapped (non-prelim): 2494
length of query: 788
length of database: 18,247,518
effective HSP length: 110
effective length of query: 678
effective length of database: 14,082,258
effective search space: 9547770924
effective search space used: 9547770924
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.