Search of human proteins with 254028232

Search of human proteins with 254028232

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|254028232 MAP/microtubule affinity-regulating kinase 2
isoform c [Homo sapiens]
         (724 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...  1444   0.0  
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...  1407   0.0  
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...  1404   0.0  
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...  1392   0.0  
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...  1339   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   952   0.0  
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   917   0.0  
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   915   0.0  
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   907   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   904   0.0  
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   647   0.0  
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor...   484   e-137
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        382   e-106
gi|116256471 SNF1-like kinase [Homo sapiens]                          360   2e-99
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         357   3e-98
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               296   6e-80
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              288   2e-77
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    271   2e-72
gi|156105707 SNF related kinase [Homo sapiens]                        269   6e-72
gi|156105705 SNF related kinase [Homo sapiens]                        269   6e-72
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   267   3e-71
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   266   5e-71
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   257   3e-68
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               256   7e-68
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       255   9e-68
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           253   4e-67
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   221   2e-57
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            191   2e-48
gi|16418343 testis-specific serine kinase 3 [Homo sapiens]            186   9e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens]           183   4e-46

>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score = 1444 bits (3737), Expect = 0.0
 Identities = 724/724 (100%), Positives = 724/724 (100%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 420

Query: 421 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 480
           SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN
Sbjct: 421 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 480

Query: 481 RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS 540
           RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS
Sbjct: 481 RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS 540

Query: 541 TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDR 600
           TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDR
Sbjct: 541 TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDR 600

Query: 601 VETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ 660
           VETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ
Sbjct: 601 VETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ 660

Query: 661 SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN 720
           SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN
Sbjct: 661 SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN 720

Query: 721 ELKL 724
           ELKL
Sbjct: 721 ELKL 724


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score = 1407 bits (3643), Expect = 0.0
 Identities = 712/725 (98%), Positives = 715/725 (98%), Gaps = 7/725 (0%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420

Query: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480

Query: 480 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 539
           NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSR 540

Query: 540 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKD 599
           STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNL+   ++ 
Sbjct: 541 STFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFAR- 599

Query: 600 RVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC 659
                RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC
Sbjct: 600 -----RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSC 654

Query: 660 QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA 719
           QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA
Sbjct: 655 QSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIA 714

Query: 720 NELKL 724
           NELKL
Sbjct: 715 NELKL 719


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score = 1404 bits (3635), Expect = 0.0
 Identities = 709/724 (97%), Positives = 709/724 (97%), Gaps = 15/724 (2%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 420
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 420

Query: 421 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 480
           SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN
Sbjct: 421 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 480

Query: 481 RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS 540
           RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS
Sbjct: 481 RSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRS 540

Query: 541 TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDR 600
           TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVR           
Sbjct: 541 TFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVR----------- 589

Query: 601 VETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ 660
               RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ
Sbjct: 590 ----RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQ 645

Query: 661 SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN 720
           SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN
Sbjct: 646 SELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIAN 705

Query: 721 ELKL 724
           ELKL
Sbjct: 706 ELKL 709


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score = 1392 bits (3604), Expect = 0.0
 Identities = 719/788 (91%), Positives = 719/788 (91%), Gaps = 64/788 (8%)

Query: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60
           MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
Sbjct: 1   MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 60

Query: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
           KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
Sbjct: 61  KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

Query: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180
           TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
Sbjct: 121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 180

Query: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
           LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
Sbjct: 181 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240

Query: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300
           YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
Sbjct: 241 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 300

Query: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360
           DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
Sbjct: 301 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

Query: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ-AGPAIPTS 419
           LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ AGPAIPTS
Sbjct: 361 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 420

Query: 420 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 479
           NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
Sbjct: 421 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 480

Query: 480 NRSRNSPLLERASLGQASIQNGKDSTA--------------------------------- 506
           NRSRNSPLLERASLGQASIQNGKDS                                   
Sbjct: 481 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 540

Query: 507 -----------------PQRVP----VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 545
                            P   P    VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
Sbjct: 541 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600

Query: 546 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV---------RRNLNEPE 596
           QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFV         RRNLNEPE
Sbjct: 601 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 660

Query: 597 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 656
           SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
Sbjct: 661 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 720

Query: 657 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 716
           NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
Sbjct: 721 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 780

Query: 717 KIANELKL 724
           KIANELKL
Sbjct: 781 KIANELKL 788


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score = 1339 bits (3466), Expect = 0.0
 Identities = 686/745 (92%), Positives = 686/745 (92%), Gaps = 54/745 (7%)

Query: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60

Query: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120

Query: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180

Query: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240

Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300

Query: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360

Query: 394 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 453
           KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP
Sbjct: 361 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 420

Query: 454 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTA------- 506
           ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS         
Sbjct: 421 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS 480

Query: 507 -------------------------------------------PQRVP----VASPSAHN 519
                                                      P   P    VASPSAHN
Sbjct: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540

Query: 520 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 579
           ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI
Sbjct: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 600

Query: 580 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 639
           FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS
Sbjct: 601 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 660

Query: 640 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 699
           SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV
Sbjct: 661 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 720

Query: 700 RFKRISGTSMAFKNIASKIANELKL 724
           RFKRISGTSMAFKNIASKIANELKL
Sbjct: 721 RFKRISGTSMAFKNIASKIANELKL 745


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  952 bits (2462), Expect = 0.0
 Identities = 516/802 (64%), Positives = 602/802 (75%), Gaps = 88/802 (10%)

Query: 3   SARTPLPTLNERDTEQPTL--GHLD-----SKPSSKSNMIRGRNSATSA-DEQPHIGNYR 54
           SARTPLPT+NERDTE  T   G+ +     +K SS+ N+ R RNS TSA DEQPHIGNYR
Sbjct: 2   SARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYR 61

Query: 55  LLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 114
           L KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SLQKLFREVRIMK+LNHPNIVK
Sbjct: 62  LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 121

Query: 115 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 174
           LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK+IVHR
Sbjct: 122 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181

Query: 175 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
           DLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW
Sbjct: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241

Query: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
           SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK L+LNP KRG+
Sbjct: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301

Query: 295 LEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEV 354
           LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+MG+ R+EI D+L+ Q+Y+EV
Sbjct: 302 LEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEV 361

Query: 355 MATYLLLGYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRR 407
           MATY+LLG K  E EG        +  + RPS+DL NS+  SP+H KVQRS+SAN KQRR
Sbjct: 362 MATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRR 421

Query: 408 FSDQAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST-----AKVPASPLPGLE 461
           FSD AGP+IP + SY+K+ Q+N+ E+++ EE D++  RK  ST     +++ ASPL G E
Sbjct: 422 FSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPE 481

Query: 462 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQ------------- 508
           RKK++  PS N+V S  +   RN+ + ER +    ++QNGKDS+  +             
Sbjct: 482 RKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV 540

Query: 509 --RVPVASP----------------------------------------SAHNISSSGGA 526
              VP A P                                        SAH+IS++   
Sbjct: 541 ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTA--T 598

Query: 527 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS----GHSQGRRGASGSIFSK 582
           PDRT FPRG SSRSTFH  QL   R+++++ Y   PASPS      +  RRG S  I SK
Sbjct: 599 PDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPASPSHETGAFAHARRGTSTGIISK 655

Query: 583 FTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSME 642
            TSKFVRR+ +E E+  R +T R         +++KEE +++KPRSLRFTWSMKTTSSM+
Sbjct: 656 ITSKFVRRDPSEGEASGRTDTSRS--TSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMD 713

Query: 643 PNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFK 702
           PN+MMREIRKVLDAN+C  E  E+++L C+HG    +  VQWEMEVCKLPRLSLNGVRFK
Sbjct: 714 PNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFK 773

Query: 703 RISGTSMAFKNIASKIANELKL 724
           RISGTS+AFKNIASKIANELKL
Sbjct: 774 RISGTSIAFKNIASKIANELKL 795


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  917 bits (2369), Expect = 0.0
 Identities = 507/758 (66%), Positives = 580/758 (76%), Gaps = 51/758 (6%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG------ 459
            AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G      
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN 479

Query: 460 ----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPV 512
                ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PV
Sbjct: 480 KADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPV 538

Query: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 568
           A  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 A--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 569 --SQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP 626
             SQ R   S ++FSK TSK  RR   E E   R E    +V     + ++K+E +EAKP
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNV-----SAEQKDENKEAKP 646

Query: 627 RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEM 686
           RSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEM
Sbjct: 647 RSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEM 706

Query: 687 EVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 724
           EVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 707 EVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 744


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  915 bits (2364), Expect = 0.0
 Identities = 508/767 (66%), Positives = 583/767 (76%), Gaps = 60/767 (7%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG------ 459
            AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G      
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN 479

Query: 460 ----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPV 512
                ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PV
Sbjct: 480 KADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPV 538

Query: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 568
           A  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 A--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 569 --SQGRRGASGSIFSKFTSKFVRRNLN---------EPESKDRVETLRPHVVGSGGNDKE 617
             SQ R   S ++FSK TSK  RRN++         E E   R E    +V     + ++
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNV-----SAEQ 646

Query: 618 KEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPG 677
           K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG   
Sbjct: 647 KDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGH 706

Query: 678 HEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 724
            E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 707 AENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  907 bits (2343), Expect = 0.0
 Identities = 503/759 (66%), Positives = 576/759 (75%), Gaps = 68/759 (8%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 411 QAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG------ 459
            AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G      
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN 479

Query: 460 ----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPV 512
                ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PV
Sbjct: 480 KADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPV 538

Query: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 568
           A  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 A--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 569 --SQGRRGASGSIFSKFTSKFVR-RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAK 625
             SQ R   S ++FSK TSK  R RN++                      ++K+E +EAK
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRSRNVSA---------------------EQKDENKEAK 630

Query: 626 PRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWE 685
           PRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWE
Sbjct: 631 PRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWE 690

Query: 686 MEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 724
           MEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 691 MEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 729


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  904 bits (2336), Expect = 0.0
 Identities = 501/752 (66%), Positives = 573/752 (76%), Gaps = 70/752 (9%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 358 YLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIP 417
           YLLLG KSSE+         RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP
Sbjct: 361 YLLLGRKSSEV---------RPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIP 411

Query: 418 TSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LER 462
           +  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G           ER
Sbjct: 412 SVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPER 470

Query: 463 KKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHN 519
           KK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+
Sbjct: 471 KKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHS 527

Query: 520 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRR 573
           ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R 
Sbjct: 528 ISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRS 582

Query: 574 GASGSIFSKFTSKFVR-RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFT 632
             S ++FSK TSK  R RN++                      ++K+E +EAKPRSLRFT
Sbjct: 583 RGSTNLFSKLTSKLTRSRNVSA---------------------EQKDENKEAKPRSLRFT 621

Query: 633 WSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLP 692
           WSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLP
Sbjct: 622 WSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLP 681

Query: 693 RLSLNGVRFKRISGTSMAFKNIASKIANELKL 724
           RLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 682 RLSLNGVRFKRISGTSIAFKNIASKIANELKL 713


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  647 bits (1670), Expect = 0.0
 Identities = 383/643 (59%), Positives = 450/643 (69%), Gaps = 57/643 (8%)

Query: 3   SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
           S+RT L   N+R+++   TLG     D  PS  S+S   R RNS  S  +EQPH+GNYRL
Sbjct: 2   SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61

Query: 56  LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
           L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 62  LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121

Query: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
           FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181

Query: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
           LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241

Query: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
           LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301

Query: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
           EQIMKD+W+N+G+E +ELKPY EP  D+ D +R E+MV MGYTREEI++SL  Q+YNEV 
Sbjct: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361

Query: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
           ATYLLLG K+ E  GD         + R  +D TN  SS+   SH K QRS S+   +QR
Sbjct: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420

Query: 407 RFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-------STAKVPASPLPG 459
           R SD  GP+    +     T +  AE K   E+R  GRKAS       S    P+SP+  
Sbjct: 421 RHSDFCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLPPSSPMVS 477

Query: 460 L----------ERKKTTPTPSTNSVLSTSTNRS----RNSPLLERASLGQASIQNGKD-S 504
                      ER+K + +   N   S  T R+       P  ER SL    + NGK+ S
Sbjct: 478 SAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSL----LPNGKENS 533

Query: 505 TAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---T 561
           +   RVP ASPS+H+++   G  +R+   RG + RSTFH GQ+R  R       GV    
Sbjct: 534 SGTPRVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGP 591

Query: 562 PASPS-GHS-----QGRRGASGSIFSKFTSKFVRRNLNEPESK 598
           PASP+  H       GR   + ++F+K TSK  RR   +P  +
Sbjct: 592 PASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKR 634


>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
           [Homo sapiens]
          Length = 659

 Score =  484 bits (1247), Expect = e-137
 Identities = 282/503 (56%), Positives = 349/503 (69%), Gaps = 51/503 (10%)

Query: 253 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 312
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236

Query: 313 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 372
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296

Query: 373 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKK 425
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K+
Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356

Query: 426 TQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----------LERKKTTPTPS 470
           +Q++ A++   +ED  S RK+S +A       PASP+ G           ERKK++  PS
Sbjct: 357 SQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPS 415

Query: 471 TNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPVASPSAHNISSSGGAP 527
           +N+     T R+      ER +  + S IQNGK+ ST P QR PVA  S H+ISS+   P
Sbjct: 416 SNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPVA--STHSISSA-ATP 471

Query: 528 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFS 581
           DR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R   S ++FS
Sbjct: 472 DRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFS 527

Query: 582 KFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSM 641
           K TSK  RRN++    K R             + ++K+E +EAKPRSLRFTWSMKTTSSM
Sbjct: 528 KLTSKLTRRNMSFRFIKSR-----------NVSAEQKDENKEAKPRSLRFTWSMKTTSSM 576

Query: 642 EPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRF 701
           +P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRF
Sbjct: 577 DPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRF 636

Query: 702 KRISGTSMAFKNIASKIANELKL 724
           KRISGTS+AFKNIASKIANELKL
Sbjct: 637 KRISGTSIAFKNIASKIANELKL 659



 Score =  281 bits (719), Expect = 2e-75
 Identities = 148/180 (82%), Positives = 157/180 (87%), Gaps = 6/180 (3%)

Query: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  382 bits (980), Expect = e-106
 Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           IG Y + +TIGKGNFA VK A H++T  +VA+KIIDKTQL+  +L+K+FREV+IMK+L H
Sbjct: 5   IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65  PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           +VD+WSLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST+CE+L++  L+L+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
           +KR ++EQI K +WM +G  D      +      K+ R+ +         M  MG  +E+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304

Query: 342 IQDSLVGQRYNEVMATYLLL 361
              SL    Y+   A Y LL
Sbjct: 305 TLQSLRSDAYDHYSAIYSLL 324


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  360 bits (925), Expect = 2e-99
 Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           +G Y + +T+GKGNFA VKLARH +T  +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I+KL++V+ET+  LY+V E+A  GE+FDYL ++G + E EAR KF QI+SAV+YCH  
Sbjct: 84  PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLK ENLLLD +M+IK+ADFGF N +  G  L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           ++D+WSLGV+LY LV GSLPFDG NL  LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263

Query: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
           ++R T+ QI + RWM                  Y   L DY D +   +M ++G  R+  
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322

Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
            +SL    YN   A Y LL      Y++++        +PRP S+DL+    P      Q
Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376

Query: 397 RSVSANP 403
             +S +P
Sbjct: 377 EGLSTDP 383


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  357 bits (915), Expect = 3e-98
 Identities = 200/436 (45%), Positives = 274/436 (62%), Gaps = 22/436 (5%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           +G Y +  T+GKGNFA VKL RH +T  EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 17  VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           P+I+KL++V+ET+  LYLV EYA  GE+FDYL  HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77  PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            IVHRDLKAENLLLD +MNIKIADFGF N F  G  L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           ++D+WS+GV+LY LV G+LPFDG  L  LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
           SKR T+ QI + +WM +  E    +P + P     +P   E       LM S+G  +++ 
Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314

Query: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
            +SL  + YN   A Y LL      ++SS   E   D    +P   A+ T + A +    
Sbjct: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLP 374

Query: 395 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 454
           V      +P  R       P      ++S       AE    EE+     K +     P 
Sbjct: 375 V---TMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPV 431

Query: 455 SPLPGLERKKTTPTPS 470
            P+  L RK     PS
Sbjct: 432 PPV--LVRKGCQSLPS 445


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  296 bits (757), Expect = 6e-80
 Identities = 204/574 (35%), Positives = 290/574 (50%), Gaps = 48/574 (8%)

Query: 49  HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
           ++G YRL KT+GKG    VKL  H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++ 
Sbjct: 30  YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89

Query: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
           HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQIVSA+ +CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
             I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G+KYDG
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
              D+WS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+  + + 
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
           P KR +LEQI K  W   G HE D   P +EP P  +            DP   E M S+
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326

Query: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
           G    RE +   L  +  N E M  YLLL  K      +   L PR   D       SP 
Sbjct: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386

Query: 392 --SHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASST 449
              H  +R    + +    +D  G   P     + +  + +++  R      +G  +SS 
Sbjct: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE-MAQHSQRSRSVSGASTG-LSSSP 444

Query: 450 AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR 509
              P SP+        +P P           R   SP  +  +L     + G     P  
Sbjct: 445 LSSPRSPVFSF-----SPEPGAG-----DEARGGGSPTSKTQTLPSRGPRGGGAGEQP-- 492

Query: 510 VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHS 569
                PSA + +   G P       G    S  H  +          P    P SP G  
Sbjct: 493 ---PPPSARS-TPLPGPPGSPRSSGGTPLHSPLHTPR----ASPTGTPGTTPPPSPGGGV 544

Query: 570 QGR--RGASGSIFSKF--TSKFVRRNLNEPESKD 599
            G   R    SI + F  + +F RR +  P +++
Sbjct: 545 GGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEE 578


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  288 bits (736), Expect = 2e-77
 Identities = 170/446 (38%), Positives = 247/446 (55%), Gaps = 21/446 (4%)

Query: 44  ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
           A    ++G YRL KT+GKG    VKL  H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 10  AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69

Query: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
           +K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQI+SA+
Sbjct: 70  LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129

Query: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
            +CH   I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G
Sbjct: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189

Query: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
           +KYDG + DVWS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+ 
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249

Query: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
            + ++ ++R TLE I K  W   G  + E       K  +  LP  +  DP   + M S+
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309

Query: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
           G  R+    +QD L  +   E M  +LLL  K      +   L PR   D       SP 
Sbjct: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368

Query: 393 HKVQRSVSANPKQRRFS----DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 448
             + R     P+++          G  +P   +      + + +  R      SG   S 
Sbjct: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424

Query: 449 TAKVPASPLPGLERKKTTPTPSTNSV 474
            +    +P P   R    PTP    V
Sbjct: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  271 bits (693), Expect = 2e-72
 Identities = 205/688 (29%), Positives = 333/688 (48%), Gaps = 63/688 (9%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69

Query: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129

Query: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308

Query: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFS 409
           +Y+ + ATYLLL  K +   G  + L+      L++ S    S      + +N       
Sbjct: 309 QYDHLTATYLLLLAKKA--RGKPVRLR------LSSFSCGQASATPFTDIKSN------- 353

Query: 410 DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA--SPLPGLERKKTTP 467
                ++    +  K   +   +    E+D  +G     T++     +   G+E K  TP
Sbjct: 354 ---NWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTP 410

Query: 468 TPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAP 527
                ++  T  N+ +N    E     +++++N +    P+     + + H        P
Sbjct: 411 -----ALCRTPANKLKNK---ENVYTPKSAVKNEEYFMFPEPKTPVNKNQHK-REILTTP 461

Query: 528 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGR-RGASGSIFSKFTSK 586
           +R   P                    +N     TP     +S G  +  +G I  +   +
Sbjct: 462 NRYTTP-----------------SKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCR 504

Query: 587 FVRRNLNEPESKDRVETLRPHVVGS--GGNDKEKEEFREAK--------PRSLRFTWSMK 636
            V  +LN+   ++  +     V GS   G DK       +K        PR L+  +++ 
Sbjct: 505 SVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVT 564

Query: 637 TTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSL 696
           TT  + P++++ EI  +L        + + Y L C   +   +  +Q+E+EVC+L +  +
Sbjct: 565 TTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDV 623

Query: 697 NGVRFKRISGTSMAFKNIASKIANELKL 724
            G+R +R+ G +  +K +   I +  K+
Sbjct: 624 VGIRRQRLKGDAWVYKRLVEDILSSCKV 651


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  269 bits (688), Expect = 6e-72
 Identities = 165/467 (35%), Positives = 250/467 (53%), Gaps = 52/467 (11%)

Query: 51  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 424
                 +  L++++ P    +   SV    + +   D          AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 425 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 466
           K  ++  +      +  EED E  +  S + +V     P +  + T+
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  269 bits (688), Expect = 6e-72
 Identities = 165/467 (35%), Positives = 250/467 (53%), Gaps = 52/467 (11%)

Query: 51  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 111 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 169
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 170 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 289 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 341
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 342 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 378
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 379 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 424
                 +  L++++ P    +   SV    + +   D          AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 425 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT 466
           K  ++  +      +  EED E  +  S + +V     P +  + T+
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  267 bits (682), Expect = 3e-71
 Identities = 153/389 (39%), Positives = 228/389 (58%), Gaps = 23/389 (5%)

Query: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131

Query: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191

Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251

Query: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306

Query: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366

Query: 386 SSAPSPSHKVQRSVSANPKQRRFSDQAGP 414
            + P P  +V   V+  P+ R   D+  P
Sbjct: 367 LTRPHP-ERVPFLVAETPRARHTLDELNP 394


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  266 bits (680), Expect = 5e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181

Query: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241

Query: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296

Query: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361
                 T  E+ +SL  G   +++   Y L+
Sbjct: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  257 bits (656), Expect = 3e-68
 Identities = 153/404 (37%), Positives = 228/404 (56%), Gaps = 38/404 (9%)

Query: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR          
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131

Query: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
                + EKE+R  F+QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  +
Sbjct: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191

Query: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
            G  L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L ++
Sbjct: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251

Query: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
           +  G +  P Y++    +LLK  L ++P KR T++ I +  W        +L  Y+ P  
Sbjct: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306

Query: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
           P Y      D    E+      + EE+   L  + + + +A   +L++  +    E    
Sbjct: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366

Query: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGP 414
            L   P     D  + + P P  +V   V+  P+ R   D+  P
Sbjct: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDELNP 409


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  256 bits (653), Expect = 7e-68
 Identities = 171/507 (33%), Positives = 256/507 (50%), Gaps = 81/507 (15%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
           Y L +T+GKG + KVK A    +G+ VA+K I K ++ +   +  + RE+ IM  LNHP+
Sbjct: 55  YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114

Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
           I+ ++EV E +  + ++MEYAS GE++DY+    R+ E+E R  FRQIVSAV YCH+  +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174

Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
           VHRDLK EN+LLD + NIKIADFG SN +     L TFCGSP YA+PE+  G+ Y GPEV
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
           D W+LGV+LYTLV G++PFDG + K L  ++  G+YR P   S D   L++  L++NP +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293

Query: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
           R T+E I    W+N G++        + L D + P                         
Sbjct: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326

Query: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
             ++A  +   ++S+ L+ DT        A +   + P+ S  +   QRS+  + K+  F
Sbjct: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377

Query: 409 SDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------- 451
           +     A+P S S     +      KR   +  S          G    ST K       
Sbjct: 378 AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCR 437

Query: 452 ----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASLG 494
               +P+SP   +PG    K + T     +L           +S  RS +S LL+   + 
Sbjct: 438 TGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVM 497

Query: 495 QASIQNGKDSTAPQRVPVASPSAHNIS 521
            +SI       +P     A  ++H++S
Sbjct: 498 GSSI------PSPSPPDPARVTSHSLS 518


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  255 bits (652), Expect = 9e-68
 Identities = 128/298 (42%), Positives = 196/298 (65%), Gaps = 8/298 (2%)

Query: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
           IG YR+   IG GNF++VKL  H LT ++VA+KI+DKT+L+  + + L RE+  M+ L+H
Sbjct: 71  IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130

Query: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
           PNI++L+EV+ET   L+LVMEYA GGE+F  +   G++ E E++  F QIVSAV++ H+ 
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190

Query: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
            I+HRDLKAEN+   ++  +K+ DFGFS     G  L+TFCGSPPYAAPELF+ + Y G 
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250

Query: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
            VD+W+LGV+LY +V+G++PF  + + +L++ +L G Y +P ++S  C  L++  L   P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310

Query: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYK-DPRRTELMVSMGYTREEIQDSL 346
           ++R  ++ IM D WM       +  PY  PL  ++ DP+      ++     E++ +L
Sbjct: 311 TERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTL 361


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  253 bits (646), Expect = 4e-67
 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
           Y  L+T+GKG + KVK AR   +G+ VA+K I K ++ +   L  + RE+ IM  LNHP+
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
           I+ + EV E    + +VMEYAS G+++DY+    ++ E+EAR  FRQIVSAV YCHQ  +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
           VHRDLK EN+LLDA+ NIKIADFG SN +  G  L TFCGSP YA+PE+  GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
           D WSLGV+LY LV G++PFDG + K L +++  G YR P   S  C  L++  L++NP++
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290

Query: 292 RGTLEQIMKDRWMNVGH 308
           R TLE +    W+N G+
Sbjct: 291 RATLEDVASHWWVNWGY 307


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  221 bits (562), Expect = 2e-57
 Identities = 140/422 (33%), Positives = 232/422 (54%), Gaps = 35/422 (8%)

Query: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110

Query: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170

Query: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230

Query: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289

Query: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349

Query: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK-------SSELEGDTITLKPRPSAD 382
            +   +GY   ++ ++++  R   ++A Y LL  K        S+++ D++  K R    
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQ-DSLCYKTR-LYQ 407

Query: 383 LTNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENK 434
           +    AP  S++             +   K+ +  ++ G  +     +SKK   N   +K
Sbjct: 408 IEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHK 465

Query: 435 RP 436
           +P
Sbjct: 466 QP 467


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  191 bits (485), Expect = 2e-48
 Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
           Y L   +G+G++AKVK A        VA+KIID+ +  +  L+K   RE+ I+ +LNH +
Sbjct: 12  YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71

Query: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
           I+K +E+ ET    +Y+VME A  G++ + +   G + E EAR KF Q+  A++YCH   
Sbjct: 72  IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131

Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
           +VHRDLK +NLLLD D NIK++DF FS      +        TFCGSP YAAPE+ QG  
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191

Query: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
           Y     D+WSLGVILY +V GS+P+D  N+K++    ++ ++R+ F    +++ +C++L+
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249

Query: 282 KKFLILNPSKRGTLEQIMKDRWM 304
              L  + ++R  +++I+   WM
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272


>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
          Length = 268

 Score =  186 bits (471), Expect = 9e-47
 Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)

Query: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
           Y+L KTIG+G ++KVK A      ++VA+K+IDK       +Q+   RE++I++ L+H N
Sbjct: 10  YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69

Query: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
           I++++E++E+ +  + LVME A GG+VFD ++  G + E  A+A FRQ+V A++YCH   
Sbjct: 70  IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129

Query: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 228
           + HRDLK EN LL    N+K+ DFGF+      ++    TFCGS  YAAPE+ QG  +D 
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188

Query: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
            + DVWS+GV+LY ++  SLPFD  ++ ++  +  +G  +     +S DC++LLK+ L  
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248

Query: 288 NPSKRGTLEQIMKDRWM 304
           +   R ++E++    W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265


>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
          Length = 358

 Score =  183 bits (465), Expect = 4e-46
 Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)

Query: 59  IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
           +GKG++AKVK A        VAVKIID+ +  +  +++   RE+ I+  +NH +I+K +E
Sbjct: 18  LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77

Query: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
           + ET +  +Y++ME    G++ +++   G + E  AR  FRQ+ SAV+YCH   IVHRDL
Sbjct: 78  IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137

Query: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
           K ENLLLD D NIK++DFGFS      +        TFCGS  YAAPE+ Q   Y     
Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197

Query: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
           D+WSLGVILY +V GS+P+D  +++++    ++ ++R+ F     ++ +C++L+ + L  
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255

Query: 288 NPSKRGTLEQIMKDRWM 304
           + S+R  +++I+   W+
Sbjct: 256 DVSQRLHIDEILSHSWL 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,388,490
Number of Sequences: 37866
Number of extensions: 1368029
Number of successful extensions: 7781
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 742
Number of HSP's successfully gapped in prelim test: 347
Number of HSP's that attempted gapping in prelim test: 4591
Number of HSP's gapped (non-prelim): 1739
length of query: 724
length of database: 18,247,518
effective HSP length: 110
effective length of query: 614
effective length of database: 14,082,258
effective search space: 8646506412
effective search space used: 8646506412
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.