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Search of human proteins with 121582655
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
(1001 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 1950 0.0
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 273 5e-73
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 273 8e-73
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 272 1e-72
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 272 1e-72
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 272 1e-72
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 272 1e-72
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 263 6e-70
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 197 5e-50
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 193 8e-49
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 122 1e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 115 3e-25
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 108 3e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 107 4e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 107 6e-23
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 106 1e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 106 1e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 106 1e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 106 1e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 105 2e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 105 2e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 105 2e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 105 2e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 105 2e-22
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 105 2e-22
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 104 4e-22
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 104 4e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 103 6e-22
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 103 1e-21
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 103 1e-21
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 1950 bits (5051), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL
Sbjct: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
Query: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN 120
AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN 120
Query: 121 RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN 180
RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN
Sbjct: 121 RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN 180
Query: 181 VTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQ 240
VTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQ
Sbjct: 181 VTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQ 240
Query: 241 ALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRW 300
ALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRW
Sbjct: 241 ALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRW 300
Query: 301 KYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGS 360
KYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGS
Sbjct: 301 KYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGS 360
Query: 361 SLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRS 420
SLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRS
Sbjct: 361 SLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRS 420
Query: 421 QPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVA 480
QPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVA
Sbjct: 421 QPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVA 480
Query: 481 EPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEAR 540
EPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEAR
Sbjct: 481 EPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEAR 540
Query: 541 LERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGARGEPLGALG 600
LERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGARGEPLGALG
Sbjct: 541 LERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGARGEPLGALG 600
Query: 601 GEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKP 660
GEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKP
Sbjct: 601 GEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKP 660
Query: 661 EAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQS 720
EAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQS
Sbjct: 661 EAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQS 720
Query: 721 KAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA 780
KAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA
Sbjct: 721 KAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA 780
Query: 781 ALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRG 840
ALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRG
Sbjct: 781 ALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRG 840
Query: 841 SLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRG 900
SLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRG
Sbjct: 841 SLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRG 900
Query: 901 RSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQD 960
RSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQD
Sbjct: 901 RSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQD 960
Query: 961 SQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE 1001
SQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE
Sbjct: 961 SQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE 1001
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 273 bits (699), Expect = 5e-73
Identities = 255/1036 (24%), Positives = 465/1036 (44%), Gaps = 115/1036 (11%)
Query: 8 SSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
S+ + WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG
Sbjct: 10 SAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHV 69
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWA 127
ECL +++ +G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+A
Sbjct: 70 ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA 129
Query: 128 ASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDK 187
A+ GC +V +LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ +
Sbjct: 130 AAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGR 189
Query: 188 SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR- 246
+AL+LACE GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+
Sbjct: 190 TALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDAD 249
Query: 247 -RGGQRLVQHPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRW 300
+ + QH ++ +S P + +A PP S + +E +
Sbjct: 250 LKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVF 309
Query: 301 KYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGS 360
E + + +E + + T A + LD+ ++ + Q+L LL + +
Sbjct: 310 FAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNK 367
Query: 361 SLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRS 420
L+ D ++ PK+ AE+ + P L
Sbjct: 368 ELQ---DKLQAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------G 402
Query: 421 QPEEQGPPQSPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVE 474
+P E PP S +S ++ + T + Q D +L + + E Q L VE
Sbjct: 403 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVE 461
Query: 475 PGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAW 534
AE V N + + +L+ +E +
Sbjct: 462 LQSRRAELV--CLNNTEISENSSDLSQKLKETQS-------------------------- 493
Query: 535 EKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEK 586
K E ++ VL+ + K GL V PE S L+ I KQD EE E+
Sbjct: 494 -KYEEAMKEVLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESER 551
Query: 587 RVPGARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQ 642
R L E+ G + K +E E ++ S +++E + + L + Q Q
Sbjct: 552 NKEKVR--ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQ 608
Query: 643 RELQSLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLR 702
E+ L L+ + EA + + +++++ + +EL + +L K ++ R
Sbjct: 609 EEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
Query: 703 GLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLS 762
D+ E +++ + ++ + D E + +++ E QL+ +
Sbjct: 667 KRKSL--EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVD 724
Query: 763 PCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVA 822
+E S+ + L ++EE++ ++ ++ K E+ KL++ L + E+ A
Sbjct: 725 AQKENSVSITEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAA 781
Query: 823 ELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSG 882
A S +EK + SL ++ +LK +++ EV ++R V++ +R
Sbjct: 782 MTDAMVPRS--SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKE 839
Query: 883 DLAA--QAAEQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKE 932
++ ++ EQE +QA E +++ +++ L+E + I + K+KE
Sbjct: 840 NIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKE 899
Query: 933 LLKKLEQL----------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARG 982
L L QL S+++ A++ + +L QL + +K H+E+IS YR HLL A +G
Sbjct: 900 ALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959
Query: 983 YMEHEVYNILLQILSM 998
M+ +V +L QIL+M
Sbjct: 960 QMDEDVQKVLKQILTM 975
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 273 bits (697), Expect = 8e-73
Identities = 254/1033 (24%), Positives = 463/1033 (44%), Gaps = 115/1033 (11%)
Query: 11 QVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECL 70
+ WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL
Sbjct: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 71 TILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASS 130
+++ +G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
Query: 131 GCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSAL 190
GC +V +LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL
Sbjct: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
Query: 191 ILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RG 248
+LACE GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ +
Sbjct: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
Query: 249 GQRLVQHPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYE 303
+ QH ++ +S P + +A PP S + +E + E
Sbjct: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
Query: 304 EERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLR 363
+ + +E + + T A + LD+ ++ + Q+L LL + + L+
Sbjct: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ 359
Query: 364 PGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPE 423
D ++ PK+ AE+ + P L +P
Sbjct: 360 ---DKLQAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPG 394
Query: 424 EQGPPQSPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGG 477
E PP S +S ++ + T + Q D +L + + E Q L VE
Sbjct: 395 ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQS 453
Query: 478 TVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKM 537
AE V N + + +L+ +E + K
Sbjct: 454 RRAELV--CLNNTEISENSSDLSQKLKETQS---------------------------KY 484
Query: 538 EARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVP 589
E ++ VL+ + K GL V PE S L+ I KQD EE E+
Sbjct: 485 EEAMKEVLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 543
Query: 590 GARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQREL 645
R L E+ G + K +E E ++ S +++E + + L + Q Q E+
Sbjct: 544 KVR--ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEI 600
Query: 646 QSLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLW 705
L L+ + EA + + +++++ + +EL + +L K ++ R
Sbjct: 601 MKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRK 658
Query: 706 DCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCR 765
D+ E +++ + ++ + D E + +++ E QL+ + +
Sbjct: 659 SL--EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK 716
Query: 766 EPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELR 825
E S+ + L ++EE++ ++ ++ K E+ KL++ L + E+ A
Sbjct: 717 ENSVSITEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTD 773
Query: 826 AREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLA 885
A S +EK + SL ++ +LK +++ EV ++R V++ +R ++
Sbjct: 774 AMVPRS--SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ 831
Query: 886 A--QAAEQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLK 935
++ EQE +QA E +++ +++ L+E + I + K+KE L
Sbjct: 832 TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALN 891
Query: 936 KLEQL----------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYME 985
L QL S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+
Sbjct: 892 SLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMD 951
Query: 986 HEVYNILLQILSM 998
+V +L QIL+M
Sbjct: 952 EDVQKVLKQILTM 964
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 272 bits (696), Expect = 1e-72
Identities = 254/1020 (24%), Positives = 455/1020 (44%), Gaps = 130/1020 (12%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S Q
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----------QDA 245
Query: 257 DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQEL 316
DL + P + S P+S ++ E P E + +E
Sbjct: 246 DLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE------------ISSIREN 293
Query: 317 VQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKD 376
+ + T A + LD+ ++ + Q+L LL + + L+ D ++ PK+
Sbjct: 294 KDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKE 348
Query: 377 LLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETI 436
AE+ + P L +P E PP S +S ++
Sbjct: 349 --AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPDSKSSPSV 386
Query: 437 ------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQ 490
+ T + Q D +L + + E Q L VE AE V N
Sbjct: 387 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV--CLNNT 443
Query: 491 LLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEW 550
+ + +L+ +E + K E ++ VL+ +
Sbjct: 444 EISENSSDLSQKLKETQS---------------------------KYEEAMKEVLSVQKQ 476
Query: 551 AKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEPLGALGGE 602
K GL V PE S L+ I KQD EE E+ R L E
Sbjct: 477 MKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--ELEEKLVE 533
Query: 603 KALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQRLQREFVP 658
+ G + K +E E ++ S +++E + + L + Q Q E+ L L+ +
Sbjct: 534 REKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT- 591
Query: 659 KPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSA 718
EA + + +++++ + +EL + +L K ++ R D+ E
Sbjct: 592 -QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--EDVTAEYIH 648
Query: 719 QSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQ 778
+++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 649 KAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQ-V 707
Query: 779 VAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKT 838
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S +EK
Sbjct: 708 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS--SYEKL 763
Query: 839 RGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAAEQE---- 892
+ SL ++ +LK +++ EV ++R V++ +R ++ ++ EQE
Sbjct: 764 QSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL 823
Query: 893 ----RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL-------- 940
+QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 824 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSK 883
Query: 941 --SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSM 998
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +L QIL+M
Sbjct: 884 RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 272 bits (696), Expect = 1e-72
Identities = 254/1027 (24%), Positives = 462/1027 (44%), Gaps = 115/1027 (11%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RGGQRLVQ 254
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ + + Q
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
Query: 255 HPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKV 309
H ++ +S P + +A PP S + +E + E +
Sbjct: 256 HDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE 315
Query: 310 VRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGM 369
+ +E + + T A + LD+ ++ + Q+L LL + + L+ D +
Sbjct: 316 ISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKL 370
Query: 370 EQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQ 429
+ PK+ AE+ + P L +P E PP
Sbjct: 371 QAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPD 408
Query: 430 SPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPV 483
S +S ++ + T + Q D +L + + E Q L VE AE V
Sbjct: 409 SKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV 467
Query: 484 GPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLER 543
N + + +L+ +E + K E ++
Sbjct: 468 --CLNNTEISENSSDLSQKLKETQS---------------------------KYEEAMKE 498
Query: 544 VLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEP 595
VL+ + K GL V PE S L+ I KQD EE E+ R
Sbjct: 499 VLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--E 555
Query: 596 LGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQR 651
L E+ G + K +E E ++ S +++E + + L + Q Q E+ L
Sbjct: 556 LEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDT 614
Query: 652 LQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPAD 711
L+ + EA + + +++++ + +EL + +L K ++ R D
Sbjct: 615 LKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--ED 670
Query: 712 LVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSL 771
+ E +++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 772 KAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAAS 831
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S
Sbjct: 731 TEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS 787
Query: 832 LRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAA 889
+EK + SL ++ +LK +++ EV ++R V++ +R ++ ++
Sbjct: 788 --SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 890 EQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL- 940
EQE +QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 941 ---------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNI 991
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKV 965
Query: 992 LLQILSM 998
L QIL+M
Sbjct: 966 LKQILTM 972
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 272 bits (696), Expect = 1e-72
Identities = 254/1027 (24%), Positives = 462/1027 (44%), Gaps = 115/1027 (11%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RGGQRLVQ 254
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ + + Q
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
Query: 255 HPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKV 309
H ++ +S P + +A PP S + +E + E +
Sbjct: 256 HDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE 315
Query: 310 VRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGM 369
+ +E + + T A + LD+ ++ + Q+L LL + + L+ D +
Sbjct: 316 ISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKL 370
Query: 370 EQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQ 429
+ PK+ AE+ + P L +P E PP
Sbjct: 371 QAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPD 408
Query: 430 SPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPV 483
S +S ++ + T + Q D +L + + E Q L VE AE V
Sbjct: 409 SKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV 467
Query: 484 GPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLER 543
N + + +L+ +E + K E ++
Sbjct: 468 --CLNNTEISENSSDLSQKLKETQS---------------------------KYEEAMKE 498
Query: 544 VLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEP 595
VL+ + K GL V PE S L+ I KQD EE E+ R
Sbjct: 499 VLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--E 555
Query: 596 LGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQR 651
L E+ G + K +E E ++ S +++E + + L + Q Q E+ L
Sbjct: 556 LEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDT 614
Query: 652 LQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPAD 711
L+ + EA + + +++++ + +EL + +L K ++ R D
Sbjct: 615 LKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--ED 670
Query: 712 LVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSL 771
+ E +++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 772 KAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAAS 831
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S
Sbjct: 731 TEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS 787
Query: 832 LRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAA 889
+EK + SL ++ +LK +++ EV ++R V++ +R ++ ++
Sbjct: 788 --SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 890 EQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL- 940
EQE +QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 941 ---------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNI 991
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKV 965
Query: 992 LLQILSM 998
L QIL+M
Sbjct: 966 LKQILTM 972
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 272 bits (696), Expect = 1e-72
Identities = 254/1027 (24%), Positives = 462/1027 (44%), Gaps = 115/1027 (11%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RGGQRLVQ 254
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ + + Q
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
Query: 255 HPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKV 309
H ++ +S P + +A PP S + +E + E +
Sbjct: 256 HDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE 315
Query: 310 VRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGM 369
+ +E + + T A + LD+ ++ + Q+L LL + + L+ D +
Sbjct: 316 ISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKL 370
Query: 370 EQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQ 429
+ PK+ AE+ + P L +P E PP
Sbjct: 371 QAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPD 408
Query: 430 SPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPV 483
S +S ++ + T + Q D +L + + E Q L VE AE V
Sbjct: 409 SKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV 467
Query: 484 GPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLER 543
N + + +L+ +E + K E ++
Sbjct: 468 --CLNNTEISENSSDLSQKLKETQS---------------------------KYEEAMKE 498
Query: 544 VLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEP 595
VL+ + K GL V PE S L+ I KQD EE E+ R
Sbjct: 499 VLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--E 555
Query: 596 LGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQR 651
L E+ G + K +E E ++ S +++E + + L + Q Q E+ L
Sbjct: 556 LEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDT 614
Query: 652 LQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPAD 711
L+ + EA + + +++++ + +EL + +L K ++ R D
Sbjct: 615 LKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--ED 670
Query: 712 LVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSL 771
+ E +++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 772 KAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAAS 831
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S
Sbjct: 731 TEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS 787
Query: 832 LRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAA 889
+EK + SL ++ +LK +++ EV ++R V++ +R ++ ++
Sbjct: 788 --SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 890 EQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL- 940
EQE +QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 941 ---------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNI 991
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKV 965
Query: 992 LLQILSM 998
L QIL+M
Sbjct: 966 LKQILTM 972
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 263 bits (672), Expect = 6e-70
Identities = 298/1105 (26%), Positives = 464/1105 (41%), Gaps = 132/1105 (11%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
W + D++LL+AV D RVAAL +RK PTKLD G+S FHLAA +G CL +++A+
Sbjct: 45 WGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAH 104
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G+++ S + G ALHLA PQC+K LLQ D VD+ + LH AA+ GC S
Sbjct: 105 GSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCS 164
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
+LC +A L+ D G TPL+IA+ H +C LLQ+GA N D ++AL+LACE
Sbjct: 165 EVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEG 224
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
S E E+LL GA G D+ G DA HY DK L HL Q ++R L +
Sbjct: 225 ASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDK-LILHLLQEAAQRPSPPSALTEDD 283
Query: 257 --DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEER--RKVVRL 312
+ +SQ S S PK P +D D E R + E R +K+ L
Sbjct: 284 SGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGL 343
Query: 313 EQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGME-- 370
EQ ++ +E ++ ++ LE Q++E Q+L V E + G++ SL+ +E
Sbjct: 344 EQHKERRQQESPEASSLHI-LERQVQE-LQQLLVERQEEKESLGREVESLQSRLSLLENE 401
Query: 371 -QGCPKDL--LAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPE---- 423
+ D+ L + EL A ++ L+P E A + Q V R E
Sbjct: 402 RENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEK 461
Query: 424 ----------EQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGV 473
E +E I A L Q HA+ L A +++ ++ +
Sbjct: 462 VQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQ-LRRQHAEALQALRQQETREVPR 520
Query: 474 EPG---------GTVAEPVGPAAM---NQLLLQLREELAAVWREKDAARGALSRPVME-- 519
E G G A GP M + + + A E+ A + ME
Sbjct: 521 EEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAE 580
Query: 520 --GALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKP---EVPSQESREGALKAA 574
GA T A E E +A ++ KP + E+
Sbjct: 581 ATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGV 640
Query: 575 PGSIKQDEEKEKRV----PGARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNL--- 627
+ + EE E + G P+ +A G A G +S + N +
Sbjct: 641 EATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEAT 700
Query: 628 --------------LEELGELGRERQRLQRELQSLSQRLQREFVPKPE--------AQVQ 665
E +L E + R L+ ++ +RE + E A+ +
Sbjct: 701 VPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAE 760
Query: 666 LQQLRQSV---------GLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGER 716
+LR+ V G + + A E+ R+ L + S LR L + A L R
Sbjct: 761 AGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLREL-EAASACLDEAR 819
Query: 717 SAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSL---KA 773
+++ A E LRA ++ + E + L L+E+ R + R L +
Sbjct: 820 ASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARD 879
Query: 774 PASPQVAAL-------EQDLGKLEEELRAVQATMSGKSQ-------------EIGKLKQL 813
A +VA L Q L +L E A++ ++ S+ L+Q
Sbjct: 880 AAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQE 939
Query: 814 LYQATEEVAELRA---RE---AASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREV 867
+ +E A LRA RE + +L +HE+ G+L A +L+ L ++ EV
Sbjct: 940 VVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEV 999
Query: 868 GRL-REAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDK 926
++ REA+ + R AQ A E+Q +R +E+ A + + + + ++K
Sbjct: 1000 FQVQREALFMKSERHA-AEAQLATAEQQLRGLRTEAER----ARQAQSRAQEALDKAKEK 1054
Query: 927 EAKIKELLKKLEQLSE------------EVLAIRGENARLALQLQDSQKNHEEIISTYRN 974
+ KI EL K++ L E EV A+R + L QLQ++ ++H +++ YR+
Sbjct: 1055 DKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRS 1114
Query: 975 HLLNAARGYMEHEVYNILLQILSME 999
HLL A +G M+ +V IL QIL M+
Sbjct: 1115 HLLYAIQGQMDEDVQRILSQILQMQ 1139
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 197 bits (500), Expect = 5e-50
Identities = 115/345 (33%), Positives = 183/345 (53%), Gaps = 10/345 (2%)
Query: 5 FSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASK 64
FSC+ WN++D +L++A RGDV +V ++ ++K P KLD G+S FH+ SK
Sbjct: 6 FSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSK 65
Query: 65 GLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPL 124
G ECL +L +G DI + + G ALHLA C++ LLQ+ + D + R+ L
Sbjct: 66 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTAL 125
Query: 125 HWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
H AA + C SS+ LLCDH A ++ D DGRTPL++A+ IC L+ RGA VN DK
Sbjct: 126 HDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDK 185
Query: 185 NDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSR 244
+++AL+L CE G + E+L+ +GAD +D+ GHD+ +YA + + L+ A
Sbjct: 186 QNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASEN 245
Query: 245 RRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEE 304
+G + + P L Q + + Q KS R + E E+ED +E
Sbjct: 246 TNKGRELWKKGPSL-QQRNLTHMQDEVNVKSHQREHQNIQDLEIENED---------LKE 295
Query: 305 ERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLS 349
RK+ + ++ L+ K + Q + + + + + ++L LL+
Sbjct: 296 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 340
Score = 110 bits (275), Expect = 7e-24
Identities = 95/420 (22%), Positives = 189/420 (45%), Gaps = 42/420 (10%)
Query: 610 KGQLEKEMSVLRLSNSNLL---EELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQL 666
K QL ++ +S + +E +L +E LQ++L+ + +++ + +
Sbjct: 993 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT 1052
Query: 667 QQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESL 726
+L + + L+ + K EKL + A Q+S + + + L Q E +
Sbjct: 1053 DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL--------QKQHVPLEQV 1104
Query: 727 EELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA---ALE 783
E L+ ++ ++ +E + + R E+ QQ L E + P + + A E
Sbjct: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1164
Query: 784 QDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843
+++G ++ LR + K +E+ KL+ + + + +L RE L +++ T+ L
Sbjct: 1165 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
Query: 844 AQAQAWGQELKALLEKYNTACREV--GRLREAVAEERRRSGDLAAQAAEQERQASEMRGR 901
Q + ++L L KY C EV + +E A++ + +L + EQE + + R
Sbjct: 1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQE--IKDQKER 1279
Query: 902 SEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL--------------------- 940
++ T L+ +++ K+ KI ELL +E+L
Sbjct: 1280 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQ 1339
Query: 941 SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEE 1000
S+ + ++ + L QL D+ + H+E+I+ YR HLL+AA+G+M+ +V LLQI+ M +
Sbjct: 1340 SQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQ 1399
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/375 (19%), Positives = 156/375 (41%), Gaps = 58/375 (15%)
Query: 679 ELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRA----CIS 734
EL++ + + ++L + +R + D + Q++ A + E +A C
Sbjct: 414 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAECKALALECER 470
Query: 735 TLVDRHREAQQV---LARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGK-LE 790
D + +Q+ L +Q+ + G + + +LK + + A+ L + L+
Sbjct: 471 VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELK 530
Query: 791 EELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEK------------- 837
++L+ ++ G S E+GKL+ + Q V E + E + ++++
Sbjct: 531 DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
Query: 838 TRGSLVAQAQAWGQELKALL------EKY----NTACREVGRLREAVAEERRRSGDLAAQ 887
+G V + + +EL A L EK+ ++ EV + + E R ++
Sbjct: 591 KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 650
Query: 888 AAEQERQASEMRGRSEQFEKTA--ELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEV- 944
+ +R+ ++ + Q K E +K ++E G + KI EL K + L +E+
Sbjct: 651 IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG---ELGKKITELTLKNQTLQKEIE 707
Query: 945 ---------------LAIRGENARLALQL-QDSQKNHEEIISTYRNHLLNAARGYMEH-- 986
L I +N + L++ +D +K+H+ II LL+ + Y E
Sbjct: 708 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 767
Query: 987 EVYNILLQILSMEEE 1001
E+ +LL+ S+ ++
Sbjct: 768 EMEKLLLENDSLSKD 782
Score = 48.5 bits (114), Expect = 3e-05
Identities = 70/355 (19%), Positives = 159/355 (44%), Gaps = 54/355 (15%)
Query: 637 ERQRLQRELQSLSQ---RLQREFVPKPEAQVQLQQLRQSVGLLTNELA-MEKEATEKLRK 692
E ++L E SLS+ RL+ FVP + + ++ L+ ++ L +L+ ++K+ E K
Sbjct: 768 EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 827
Query: 693 L--LASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACIS-TLVDRHREAQQVLAR 749
+ L S+++ L+ + S Q ++ EE++ ++ TL +RE V +
Sbjct: 828 IHALTSENTNLKKMM-----------SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKK 876
Query: 750 LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809
++ NQ+ +K ++ L+++L + +++A +++ ++
Sbjct: 877 FEDINQEF-------------VKIKDKNEI--LKRNLENTQNQIKAEYISLAEHEAKMSS 921
Query: 810 LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869
L Q + + + AE+ A+ R+ ++ +L A+ +A +EL + E +
Sbjct: 922 LSQSMRKVQDSNAEI----LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 977
Query: 870 LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDK--- 926
E + + +L Q +EQ ++ S ++ ++ + LK+++ L RDK
Sbjct: 978 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1037
Query: 927 -----------EAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIIS 970
K EL K+L+ LS++ ++ +L ++++ K EI++
Sbjct: 1038 IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL---VEENAKQTSEILA 1089
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 193 bits (490), Expect = 8e-49
Identities = 112/333 (33%), Positives = 179/333 (53%), Gaps = 10/333 (3%)
Query: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
WN++D +L++A RGDV +V ++ ++K P KLD G+S FH+ SKG ECL +L +
Sbjct: 31 WNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIH 90
Query: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
G DI + + G ALHLA C++ LLQ+ + D + R+ LH AA + C SS+
Sbjct: 91 GVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSI 150
Query: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
LLCDH A ++ D DGRTPL++A+ IC L+ RGA VN DK +++AL+L CE
Sbjct: 151 QLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEY 210
Query: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
G + E+L+ +GAD +D+ GHD+ +YA + + L+ A +G + + P
Sbjct: 211 GCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGP 270
Query: 257 DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQEL 316
L Q + + Q KS R + E E+ED +E RK+ + ++ L
Sbjct: 271 SL-QQRNLTHMQDEVNVKSHQREHQNIQDLEIENED---------LKERLRKIQQEQRIL 320
Query: 317 VQKTEECKTQAAAYLDLENQIREQAQELGVLLS 349
+ K + Q + + + + + ++L LL+
Sbjct: 321 LDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 353
Score = 110 bits (275), Expect = 7e-24
Identities = 95/420 (22%), Positives = 189/420 (45%), Gaps = 42/420 (10%)
Query: 610 KGQLEKEMSVLRLSNSNLL---EELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQL 666
K QL ++ +S + +E +L +E LQ++L+ + +++ + +
Sbjct: 1006 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT 1065
Query: 667 QQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESL 726
+L + + L+ + K EKL + A Q+S + + + L Q E +
Sbjct: 1066 DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL--------QKQHVPLEQV 1117
Query: 727 EELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA---ALE 783
E L+ ++ ++ +E + + R E+ QQ L E + P + + A E
Sbjct: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1177
Query: 784 QDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843
+++G ++ LR + K +E+ KL+ + + + +L RE L +++ T+ L
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 844 AQAQAWGQELKALLEKYNTACREV--GRLREAVAEERRRSGDLAAQAAEQERQASEMRGR 901
Q + ++L L KY C EV + +E A++ + +L + EQE + + R
Sbjct: 1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQE--IKDQKER 1292
Query: 902 SEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL--------------------- 940
++ T L+ +++ K+ KI ELL +E+L
Sbjct: 1293 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQ 1352
Query: 941 SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEE 1000
S+ + ++ + L QL D+ + H+E+I+ YR HLL+AA+G+M+ +V LLQI+ M +
Sbjct: 1353 SQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 51.2 bits (121), Expect = 5e-06
Identities = 74/375 (19%), Positives = 156/375 (41%), Gaps = 58/375 (15%)
Query: 679 ELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRA----CIS 734
EL++ + + ++L + +R + D + Q++ A + E +A C
Sbjct: 427 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAECKALALECER 483
Query: 735 TLVDRHREAQQV---LARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGK-LE 790
D + +Q+ L +Q+ + G + + +LK + + A+ L + L+
Sbjct: 484 VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELK 543
Query: 791 EELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEK------------- 837
++L+ ++ G S E+GKL+ + Q V E + E + ++++
Sbjct: 544 DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
Query: 838 TRGSLVAQAQAWGQELKALL------EKY----NTACREVGRLREAVAEERRRSGDLAAQ 887
+G V + + +EL A L EK+ ++ EV + + E R ++
Sbjct: 604 KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 663
Query: 888 AAEQERQASEMRGRSEQFEKTA--ELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEV- 944
+ +R+ ++ + Q K E +K ++E G + KI EL K + L +E+
Sbjct: 664 IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG---ELGKKITELTLKNQTLQKEIE 720
Query: 945 ---------------LAIRGENARLALQL-QDSQKNHEEIISTYRNHLLNAARGYMEH-- 986
L I +N + L++ +D +K+H+ II LL+ + Y E
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 780
Query: 987 EVYNILLQILSMEEE 1001
E+ +LL+ S+ ++
Sbjct: 781 EMEKLLLENDSLSKD 795
Score = 48.5 bits (114), Expect = 3e-05
Identities = 70/355 (19%), Positives = 159/355 (44%), Gaps = 54/355 (15%)
Query: 637 ERQRLQRELQSLSQ---RLQREFVPKPEAQVQLQQLRQSVGLLTNELA-MEKEATEKLRK 692
E ++L E SLS+ RL+ FVP + + ++ L+ ++ L +L+ ++K+ E K
Sbjct: 781 EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 840
Query: 693 L--LASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACIS-TLVDRHREAQQVLAR 749
+ L S+++ L+ + S Q ++ EE++ ++ TL +RE V +
Sbjct: 841 IHALTSENTNLKKMM-----------SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKK 889
Query: 750 LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809
++ NQ+ +K ++ L+++L + +++A +++ ++
Sbjct: 890 FEDINQEF-------------VKIKDKNEI--LKRNLENTQNQIKAEYISLAEHEAKMSS 934
Query: 810 LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869
L Q + + + AE+ A+ R+ ++ +L A+ +A +EL + E +
Sbjct: 935 LSQSMRKVQDSNAEI----LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
Query: 870 LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDK--- 926
E + + +L Q +EQ ++ S ++ ++ + LK+++ L RDK
Sbjct: 991 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1050
Query: 927 -----------EAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIIS 970
K EL K+L+ LS++ ++ +L ++++ K EI++
Sbjct: 1051 IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL---VEENAKQTSEILA 1102
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 122 bits (307), Expect = 1e-27
Identities = 74/208 (35%), Positives = 110/208 (52%), Gaps = 1/208 (0%)
Query: 19 RHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGA 78
R L++A+ GD V AL +K + D+ ++P H AA G E + +L+ +GA
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQ-DNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 79 DINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLL 138
+N+K+ T LH A SC + V+VLL+H A+ +A D ++PLH AA++
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 139 LCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGS 198
L + ++V D GRT L A+ GH + LL RGA +N DK D+ A+ A G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
EV +LL+SHGA+ D + LH A
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAA 213
Score = 103 bits (257), Expect = 8e-22
Identities = 70/222 (31%), Positives = 100/222 (45%), Gaps = 3/222 (1%)
Query: 16 RWNRHDQKLLEAVHRGDVG---RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTI 72
R N D K L +HR + + SA D N Q+P H+AA+ +C
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 73 LLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGC 132
L+ +++N + G TALH A S + VK+LL GAN +A D ++R +HWAA G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 133 ASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALIL 192
V LL H A + D TPL A+ G ++ LL G +N + + L +
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 193 ACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKAL 234
AC G V L+ GA + G LH+A + AL
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Score = 99.0 bits (245), Expect = 2e-20
Identities = 61/173 (35%), Positives = 91/173 (52%), Gaps = 4/173 (2%)
Query: 56 SPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA 115
SP HLAA G + L +L+ + D++ +N G T L LA +CV VL+ GA+
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 116 VD-AENRSPLHWAASSGCASSVLLL---CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
D R+P+H AA++G + + LL + + +D+ D +G+TPLM++ L GH
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
LL +GA V+ DK ++AL G E + LL HGA DS G +H
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
Score = 92.4 bits (228), Expect = 2e-18
Identities = 66/214 (30%), Positives = 93/214 (43%), Gaps = 38/214 (17%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D NGQ+P L+ G T+C+ LL GA++++K++ G TALH ++ +CV LLQHG
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLD----VLDNDGRTPLMIASLGGHA 166
A D+ R+P+H +A+ G + L A +D DN G T L A GH
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 167 AICSQLLQR----------------------------------GARVNVTDKNDKSALIL 192
LL++ + VN TD ++ L
Sbjct: 770 TCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829
Query: 193 ACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
A E +LLLSH A +VDSTG L A
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMA 863
Score = 91.7 bits (226), Expect = 3e-18
Identities = 61/211 (28%), Positives = 94/211 (44%), Gaps = 1/211 (0%)
Query: 18 NRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANG 77
N L A + GD + L AR DS +P H A + E + +LL +
Sbjct: 39 NEKRTPLHAAAYLGDA-EIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97
Query: 78 ADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVL 137
AD+N+++++ T LH+A + +C + L+ +N + D R+ LH AA SG V
Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVK 157
Query: 138 LLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKG 197
LL A ++ D R + A+ GH + L+ GA V DK + L A G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 198 SAEVAELLLSHGADAGAVDSTGHDALHYALH 228
V + LL G D ++ G+ LH A +
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Score = 85.1 bits (209), Expect = 3e-16
Identities = 56/174 (32%), Positives = 81/174 (46%), Gaps = 1/174 (0%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ-CVKVLLQHGAN 112
G +P H+A G + L+ GA +N KNE G T LH A S C+++L+ +GA+
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 298
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
+ + ++PLH A G S + A +D D +G TPL IA+ GH + + L
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
+ GA + L LA G ++ LLS G D D G LH A
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412
Score = 85.1 bits (209), Expect = 3e-16
Identities = 61/187 (32%), Positives = 92/187 (49%), Gaps = 7/187 (3%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINS---K 83
A +G V V L ++ ++ K ++P H AA+ G +ECL +L+ N N+ +
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+ +G T L L+ ++ CV LL GAN DA D R+ LH A +G V L H
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN----VTDKNDKSALILACEKGSA 199
A + D+ GRTP+ +++ GH + LLQ A ++ D + +AL AC G
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 200 EVAELLL 206
ELLL
Sbjct: 770 TCVELLL 776
Score = 84.3 bits (207), Expect = 5e-16
Identities = 58/194 (29%), Positives = 90/194 (46%), Gaps = 1/194 (0%)
Query: 34 GRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHL 93
G + L + A D + H AA G E + +L+++GA++ K++ T LH
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
Query: 94 ATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDG 153
A S VK LL G + + +A +PLH A +G V L D A ++ + G
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 154 RTPLMIASLGGHAAICSQLL-QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADA 212
TPL A+ H A+C +LL GA VN+ K+ K+ L + G ++ ++ GA
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 213 GAVDSTGHDALHYA 226
D G+ LH A
Sbjct: 333 DCEDKNGNTPLHIA 346
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/204 (30%), Positives = 102/204 (50%), Gaps = 7/204 (3%)
Query: 29 HRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS 88
H G +G + A+ A P D++G + H A G C+ +LL ++ K E +
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ--EVFQKTEGNA 788
Query: 89 -TALHLATISCQPQCVKVLLQH-GAN-EDAVDAENRSPLHWAASSGCASSVLLLCDHEAF 145
+ LH A I+ ++L+ GA+ +A D++ R+PLH AA + + LL H A
Sbjct: 789 FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
Query: 146 LDVLDNDGRTPLMIASLGGHAAICSQLL-QRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +D+ G+TPLM+A+ G L+ A + + D + +AL LAC KG A L
Sbjct: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
Query: 205 LLSHGADAGAVDSTGHDALHYALH 228
+L D +++T + AL LH
Sbjct: 909 ILEKITDRNLINAT-NAALQTPLH 931
Score = 82.4 bits (202), Expect = 2e-15
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 1/177 (0%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D NG +P H+AA G + L+ +GAD + G LHLA +S C + LL G
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG 395
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
+ D D R+ LH AA+ G + LL + A + D GR+PL A+ +
Sbjct: 396 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 455
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGS-AEVAELLLSHGADAGAVDSTGHDALHYA 226
L+ GA VN D+ + L A + + E LL + A+ G D G++A+HY+
Sbjct: 456 ALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
Score = 80.5 bits (197), Expect = 7e-15
Identities = 55/180 (30%), Positives = 88/180 (48%), Gaps = 1/180 (0%)
Query: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVK 104
A K +G P HLAA G ++C LL++G DI++ ++ G T LH A +C+
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
Query: 105 VLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGG 164
+LL GA+ + D RSPLH+AA++ + L A ++ LD G TPL A+
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
Query: 165 HAAICSQ-LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDAL 223
C + LL+ A + DK +A+ + G +L+ S ++++G D L
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
Score = 80.1 bits (196), Expect = 1e-14
Identities = 56/186 (30%), Positives = 95/186 (51%), Gaps = 8/186 (4%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNED-GSTALHLATISCQPQCVKVLLQH 109
+S+G++P LAA KG EC+ +L+ GA I K+ T +H A + +C+++L+ +
Sbjct: 580 NSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN 639
Query: 110 GANEDAVDAEN---RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
++AVD ++ ++PL + +G V L + A +D D GRT L ++ GH
Sbjct: 640 AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699
Query: 167 AICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL----SHGADAGAVDSTGHDA 222
LLQ GA+ + D ++ + L+ G V LL S A+ D+ G+ A
Sbjct: 700 ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759
Query: 223 LHYALH 228
LH+A +
Sbjct: 760 LHWACY 765
Score = 79.7 bits (195), Expect = 1e-14
Identities = 48/156 (30%), Positives = 82/156 (52%)
Query: 73 LLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGC 132
L+ D+N ++ + T LH A + +++L+ GA +A D++ +PLH A +S
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 133 ASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALIL 192
+V +L H A ++ D + +TPL IA+ L+ + VNV+D+ ++AL
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 193 ACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
A G E+ +LLLS GA+ A D A+H+A +
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
Score = 76.3 bits (186), Expect = 1e-13
Identities = 52/174 (29%), Positives = 80/174 (45%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
+G++P H+ A G ++ +GA I+ ++++G+T LH+A + L+ GA+
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
PLH AA SG + L +D D+ GRT L A+ GG+ + L
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
L GA N DK +S L A + + L+ GA +D G LHYA
Sbjct: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 5/162 (3%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
DS G++P H AA ECL +LL++ A +NS + G T L +A + Q V++L+
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879
Query: 111 ANEDAV-DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDG---RTPLMIASLGGHA 166
+ E + D + LH A S G +S LL+ + ++++ +TPL +A+ G
Sbjct: 880 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 939
Query: 167 AICSQLLQRGARVNVTDKNDKS-ALILACEKGSAEVAELLLS 207
+ +LL +GA V D+N + AL A K A+ L+L+
Sbjct: 940 MVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA 981
Score = 44.7 bits (104), Expect = 4e-04
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 3/103 (2%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD---I 80
L+ A G V L S SA T D++ + HLA SKG ++L D I
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 81 NSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSP 123
N+ N T LH+A + V+ LL GA+ AVD +P
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 115 bits (287), Expect = 3e-25
Identities = 66/189 (34%), Positives = 104/189 (55%)
Query: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
LDS ++P H+AA G E + +L+ +GA +N+K+ T LH A S + V+VL++H
Sbjct: 12 LDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71
Query: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
A+ +A D ++PLH AA++ ++ + ++V D GRT L A+L GH +
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHT 229
+ LL +GA +N DK D+ AL A G +V LL++HGA+ D G+ LH A
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 230 QDKALWRHL 238
+ +HL
Sbjct: 192 GQINVVKHL 200
Score = 110 bits (276), Expect = 5e-24
Identities = 69/222 (31%), Positives = 105/222 (47%), Gaps = 3/222 (1%)
Query: 16 RWNRHDQKLLEAVHRGDVGR---VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTI 72
R N D L +HR R + + SA D N Q+P H+AA+ +C +
Sbjct: 41 RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEV 100
Query: 73 LLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGC 132
++ + +N + G TALH A ++ + V +LL GAN +A D ++R LHWAA G
Sbjct: 101 IIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGH 160
Query: 133 ASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALIL 192
V LL +H A + D G TPL A+ G + LL G ++ + +AL +
Sbjct: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Query: 193 ACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKAL 234
AC G V L+ +GA+ ++ G LH+A + AL
Sbjct: 221 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
Score = 96.3 bits (238), Expect = 1e-19
Identities = 69/195 (35%), Positives = 97/195 (49%), Gaps = 7/195 (3%)
Query: 55 QSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANED 114
+SP HLAA G + L +LL + D++ ++E G TAL LA +CV+ L+ GA+
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
Query: 115 AVD-AENRSPLHWAASSG---CASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
D R+PLH + +G C +L + D+ +DV D G+TPLM+A GH S
Sbjct: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
LL++ A V+ D +AL G E ++LL DS G LHYA +
Sbjct: 663 LLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA-AR 721
Query: 231 DKALW--RHLQQALS 243
A W LQ ALS
Sbjct: 722 GHATWLSELLQMALS 736
Score = 94.0 bits (232), Expect = 6e-19
Identities = 65/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
L A G V V L + K A D + H AA G + + +L+ +GA++ K
Sbjct: 119 LHHAALNGHVEMVNLLLA-KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
++ G T LH A + Q VK LL G D ++ + LH A +G + V L D+
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYG 237
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLL-QRGARVNVTDKNDKSALILACEKGSAEVA 202
A ++ +N+G TPL A+ H A+C +LL GA VN+ K+ KS L + G +
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRS 297
Query: 203 ELLLSHGADAGAVDSTGHDALHYA 226
+ L+ +G + VD G+ LH A
Sbjct: 298 QTLIQNGGEIDCVDKDGNTPLHVA 321
Score = 85.9 bits (211), Expect = 2e-16
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 34/207 (16%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ-CVKVLLQHGAN 112
G + H+A G + L+ GA++N N +G T LH A S C+++L+ +GA+
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMI------------- 159
+ + +SPLH A G + L + +D +D DG TPL +
Sbjct: 274 VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
Query: 160 --------------------ASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
A+L H+ C +LL G ++ DK ++ L A G+
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E +LL S GAD D G LHYA
Sbjct: 394 ECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 79.3 bits (194), Expect = 2e-14
Identities = 60/186 (32%), Positives = 93/186 (50%), Gaps = 9/186 (4%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSK-NEDGSTALHLATISCQPQCVKVLLQH 109
D G++ LAA KG TEC+ L+ GA I K N T LH + I+ C+++LL+
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI 631
Query: 110 GANEDAV---DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
N +AV DA+ ++PL A + G +V LL + EA +D +D G T L + GH
Sbjct: 632 ADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHE 691
Query: 167 AICSQLLQRGARVNVTDKNDKSALILACEKGSA----EVAELLLSHGADAGAVDSTGHDA 222
LL++ + D ++ L A +G A E+ ++ LS D D+ G+
Sbjct: 692 ECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE-EDCCFKDNQGYTP 750
Query: 223 LHYALH 228
LH+A +
Sbjct: 751 LHWACY 756
Score = 78.2 bits (191), Expect = 4e-14
Identities = 59/205 (28%), Positives = 94/205 (45%), Gaps = 13/205 (6%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D G++ H AA+ G EC+ +L ++GAD + K++ G T LH A +C C++ L+ G
Sbjct: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN + D R+ LH+AA+S + +L + DN A +C
Sbjct: 437 ANVNETDDWGRTALHYAAASDMDRNKTILGNAH------DNSEELERARELKEKEATLCL 490
Query: 171 Q-LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLS------HGADAGAVDSTGHDAL 223
+ LLQ A ++ DK +++ A G + ELLL +D+GA S H A
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAA 550
Query: 224 HYALHTQDKALWRHLQQALSRRRRG 248
+ H + L + L R +G
Sbjct: 551 YNGHHQALEVLLQSLVDLDIRDEKG 575
Score = 77.4 bits (189), Expect = 6e-14
Identities = 46/157 (29%), Positives = 81/157 (51%)
Query: 72 ILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSG 131
+L+ D+N+ + + T LH+A + +++L+ GA +A D +PLH A +S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 132 CASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALI 191
+V +L H A ++ D + +TPL +A+ ++ + VNV+D+ ++AL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 192 LACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
A G E+ LLL+ GA+ A D ALH+A +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/205 (28%), Positives = 82/205 (40%), Gaps = 28/205 (13%)
Query: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
+D +G +P H+AA G + L +GAD LHLA ++ C + LL
Sbjct: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
G D D R+ LH AA+ G + LL A D GRTPL A+ H
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429
Query: 170 SQLLQRGARVNVTDKNDKSALILAC----------------------------EKGSAEV 201
L+ GA VN TD ++AL A EK +
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489
Query: 202 AELLLSHGADAGAVDSTGHDALHYA 226
E LL + A+ D G++++HYA
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYA 514
Score = 75.1 bits (183), Expect = 3e-13
Identities = 52/174 (29%), Positives = 76/174 (43%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
+G+SP H+ A G L+ NG +I+ ++DG+T LH+A + L GA+
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
+ PLH AA + + L +D D GRT L A+ GG+ L
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
GA + DK ++ L A E L++ GA+ D G ALHYA
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 73.2 bits (178), Expect = 1e-12
Identities = 62/208 (29%), Positives = 90/208 (43%), Gaps = 7/208 (3%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
L+ AV G + V+ L K A +D G + H G EC+ +LL I K
Sbjct: 649 LMLAVAYGHIDAVSLLLE-KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK 707
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAV---DAENRSPLHWAASSGCASSVLLLC 140
+ G T LH A + LLQ +E+ D + +PLHWA +G + + +L
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 141 DHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQR--GARVNVTDKNDKSALILACEKGS 198
+ + F + N TPL A + H S LL + V+ D ++ L A
Sbjct: 768 EQKCFRKFIGNPF-TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADH 826
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
E +LLL H A AVD++G AL A
Sbjct: 827 VECLQLLLRHSAPVNAVDNSGKTALMMA 854
Score = 70.1 bits (170), Expect = 1e-11
Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 40/220 (18%)
Query: 64 KGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQ--HGANEDAVDAENR 121
K T CL LL N A+ + ++++G ++H A QC+++LL+ + E++ +
Sbjct: 484 KEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK 543
Query: 122 SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGA---- 177
SPLH AA +G ++ +L LD+ D GRT L +A+ GH L+ GA
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
Query: 178 ---------------------------------RVNVTDKNDKSALILACEKGSAEVAEL 204
V+V D ++ L+LA G + L
Sbjct: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
Query: 205 LLSHGADAGAVDSTGHDALHYALHT-QDKALWRHLQQALS 243
LL A+ VD G ALH + T ++ + L+Q +S
Sbjct: 664 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Score = 69.7 bits (169), Expect = 1e-11
Identities = 57/186 (30%), Positives = 82/186 (44%), Gaps = 6/186 (3%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLA---NGADINSK 83
A +G V AL + ++ K + ++P H + G T CL +LL N ++ K
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+ G T L LA V +LL+ AN D VD + LH +G V +L + E
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN---VTDKNDKSALILACEKGSAE 200
+ D+ GRTPL A+ GHA S+LLQ D + L AC G+
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 201 VAELLL 206
E+LL
Sbjct: 762 CIEVLL 767
Score = 69.7 bits (169), Expect = 1e-11
Identities = 53/171 (30%), Positives = 81/171 (47%), Gaps = 8/171 (4%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D+ G +P H A G C+ +LL + T LH A I+ C +LL G
Sbjct: 744 DNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLL--G 800
Query: 111 ANEDAV----DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
A + ++ D + R+PL AA + + LL H A ++ +DN G+T LM+A+ G A
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 167 AICSQLLQRG-ARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVD 216
L+ A + V DK+ + L LAC KG + A L+L D ++
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Score = 61.6 bits (148), Expect = 4e-09
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 5/152 (3%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLA--NGADINSKN 84
A + G+ + L +K R K N +P H A C ++LL + + ++ ++
Sbjct: 754 ACYNGNENCIEVLLEQKCFR--KFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Query: 85 EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV-LLLCDHE 143
+ G T L A + +C+++LL+H A +AVD ++ L AA +G A +V +L+ +
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQ 871
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQR 175
A L V D D TPL +A GH +L +
Sbjct: 872 ADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Score = 40.0 bits (92), Expect = 0.011
Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 39 LASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANG-ADINSKNEDGSTALHLATIS 97
L R SA +D++G++ +AA G + IL+ + AD+ K++D +T LHLA
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSK 891
Query: 98 CQPQCVKVLLQHGANEDAVDAENRS 122
+C ++L +E ++ +N +
Sbjct: 892 GHEKCALLILDKIQDESLINEKNNA 916
Score = 36.6 bits (83), Expect = 0.12
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD---I 80
L+ A G G V L + A T D + +P HLA SKG +C ++L D I
Sbjct: 851 LMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLI 910
Query: 81 NSKN 84
N KN
Sbjct: 911 NEKN 914
Score = 33.1 bits (74), Expect = 1.3
Identities = 19/61 (31%), Positives = 31/61 (50%)
Query: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQD 231
L+ + VN D ++ L +A G AE+ ELL+ GA A D+ LH A+ ++
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 232 K 232
+
Sbjct: 62 E 62
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 108 bits (270), Expect = 3e-23
Identities = 75/210 (35%), Positives = 105/210 (50%), Gaps = 6/210 (2%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
L A + G + V L SR + + D++G +P LAA +G T+ + L+ GA+IN
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHT 607
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
++DG TAL A + V LL G D DA++R+ L AA G VL L H
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILAC-----EKGS 198
A ++ DN+GRT L+ A+ GH I LL GA VN D + ++AL +A KG
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYALH 228
A V LL+ GA+ D G L A +
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
Score = 107 bits (268), Expect = 4e-23
Identities = 77/271 (28%), Positives = 123/271 (45%), Gaps = 46/271 (16%)
Query: 2 KRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVG----RVAALASRK---------SARPT 48
+ + S +S Q VE + L+ HR D G +AA + AR
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 49 KLDSNGQSPFHLAASKGLTECLTILLAN-------------------------------- 76
++D++G+ PF LA+ +G +C+ ILL N
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
Query: 77 -GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASS 135
GAD+N K+ DG L++ + Q + L++GAN +A DAE R+ LH + G
Sbjct: 935 HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 136 VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACE 195
V +L + A ++ DN+ R+ L A+ GH + L++ GA V+ T +AL +A +
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Query: 196 KGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
+G +V ++LL HGAD D G A+ A
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Score = 106 bits (264), Expect = 1e-22
Identities = 74/225 (32%), Positives = 107/225 (47%), Gaps = 20/225 (8%)
Query: 8 SSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
S T + W H+ +L + G A K D+ G++ AA G
Sbjct: 644 SRTALRAAAWGGHEDIVLNLLQHG-------------AEVNKADNEGRTALIAAAYMGHR 690
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQP------QCVKVLLQHGANEDAVDAENR 121
E + LL +GA++N ++ DG TAL +A + C P V +L+ GA D D +
Sbjct: 691 EIVEHLLDHGAEVNHEDVDGRTALSVAAL-CVPASKGHASVVSLLIDRGAEVDHCDKDGM 749
Query: 122 SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNV 181
+PL AA G V LL + A +D DN+GRTPL+ A+ GHA++ + LL GA V+
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 182 TDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
D ++ L +A +G+ EV LL G D D G LH A
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Score = 100 bits (249), Expect = 7e-21
Identities = 66/201 (32%), Positives = 100/201 (49%), Gaps = 1/201 (0%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
LL A + G V V L A D+NG++P AAS G + LL GA ++S
Sbjct: 752 LLVAAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+ +G T L +A+ + V+ LL G +E+ D +PLH AA G L +
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE 203
A + +DNDGR P ++AS GH LL+ + ++ + ++AL +A +G ++ E
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 204 LLLSHGADAGAVDSTGHDALH 224
LL SHGAD D+ G L+
Sbjct: 931 LLFSHGADVNCKDADGRPTLY 951
Score = 96.7 bits (239), Expect = 1e-19
Identities = 65/182 (35%), Positives = 87/182 (47%)
Query: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVK 104
A + DSNG++ AA G + + +L++ GAD+ ++ G T L LA + V
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 105 VLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGG 164
L+ GAN + D + + L AA G V L +D D D RT L A+ GG
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 165 HAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
H I LLQ GA VN D ++ALI A G E+ E LL HGA+ D G AL
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 225 YA 226
A
Sbjct: 716 VA 717
Score = 95.5 bits (236), Expect = 2e-19
Identities = 54/175 (30%), Positives = 89/175 (50%)
Query: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
+DS G++ +A+++G E + LL G D N +++ G T LH+A + L++
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Query: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
GA + +D + R P A+ G V +L ++++ +D DGR L +A+L GH I
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
L GA VN D + + L + + +AE L +GA+ A D+ G ALH
Sbjct: 930 ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH 984
Score = 94.4 bits (233), Expect = 5e-19
Identities = 58/186 (31%), Positives = 96/186 (51%), Gaps = 3/186 (1%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
V +L + A D +G +P +AA +G + + +LL GAD++ + +G T L A
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
V LL GA D++D+E R+ L A++ G V L D + D+ G T
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH IC L+++GAR N D + + ILA ++G + ++LL + ++ +
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN---I 906
Query: 216 DSTGHD 221
D G+D
Sbjct: 907 DQRGYD 912
Score = 89.4 bits (220), Expect = 2e-17
Identities = 52/162 (32%), Positives = 88/162 (54%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D++G+ ++ A + L NGA++ + + +G TALH++ + V+VL+ +
Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
A+ +A D E RS L AA G V LL +H A +D N G T L IA+ GH +
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADA 212
LL+ GA N D+ ++A+ +A + G +++ +LL +GA +
Sbjct: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS 1104
Score = 86.7 bits (213), Expect = 1e-16
Identities = 56/171 (32%), Positives = 82/171 (47%)
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWA 127
+ + LL NGA +N + +G T L A S V +L+ GA+ + DA +PL A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 128 ASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDK 187
A G V L A ++ D DG T L A+ GGH + S LL G +V+ D + +
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
Query: 188 SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHL 238
+AL A G ++ LL HGA+ D+ G AL A + + + HL
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Score = 74.7 bits (182), Expect = 4e-13
Identities = 53/159 (33%), Positives = 78/159 (49%), Gaps = 2/159 (1%)
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWA 127
E L +L+ GA +NS ED T+ + + ++ LL +GA+ + D+ R+ L A
Sbjct: 495 EVLQLLVKAGAHVNS--EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 128 ASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDK 187
A SG V LL A L++ D G TPL +A+ GH + + L+ GA +N TD++
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
Query: 188 SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
+AL A G EV LL G D+ AL A
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 107 bits (268), Expect = 4e-23
Identities = 72/203 (35%), Positives = 106/203 (52%), Gaps = 1/203 (0%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
L++A+ DV V +L S+K LD ++P H AA G L +LL +GA++N+K
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+ T LH A S + + +LL H A+ +A D ++PLH AA++ L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE 203
+ L+V D GR+ L A GH + LL +GA +NV DK ++ L A G EV +
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 204 LLLSHGADAGAVDSTGHDALHYA 226
LL++ GAD G D G+ LH A
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTA 213
Score = 97.1 bits (240), Expect = 8e-20
Identities = 69/204 (33%), Positives = 102/204 (50%), Gaps = 2/204 (0%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
L AVH G + V L + K A D + P H AA G E L +L+A GAD+ K
Sbjct: 144 LHHAVHSGHLETVNLLLN-KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK 202
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+ G LH A S Q + VK LL+ GA D +A + LH A G + + L +
Sbjct: 203 DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAG 262
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLL-QRGARVNVTDKNDKSALILACEKGSAEVA 202
A ++ ++ G TPL +A++ + A+C +LL GA VN K KS L +A G +
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322
Query: 203 ELLLSHGADAGAVDSTGHDALHYA 226
++L+ +G++ D G+ LH A
Sbjct: 323 QILIQNGSEIDCADKFGNTPLHVA 346
Score = 95.1 bits (235), Expect = 3e-19
Identities = 66/190 (34%), Positives = 93/190 (48%), Gaps = 4/190 (2%)
Query: 56 SPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA 115
SP HLAA G E L L +++ ++ G TAL LAT +CV+VL HGA+
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 116 VDAENR-SPLHWAASSGCASSVLLLCD---HEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
+ + + +PLH AA+SG S+ LL D DV+D G+TPLM+A + GH
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
Query: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQD 231
LL++G+ + D ++AL G + LL H A D G +H A
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
Query: 232 KALWRHLQQA 241
A+ R L QA
Sbjct: 767 TAVLRTLLQA 776
Score = 93.6 bits (231), Expect = 8e-19
Identities = 66/182 (36%), Positives = 101/182 (55%), Gaps = 5/182 (2%)
Query: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
+D +G SP H A+ G +CL +LL + + + + T LH A I+ Q ++LL
Sbjct: 787 VDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGA 845
Query: 110 -GAN-EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAA 167
GA ++ DA+ R+PLH AA + S + +L H+A ++ D+ GRT LM A+ G A
Sbjct: 846 LGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTA 905
Query: 168 ICSQLLQRG-ARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LL RG A + V D+N +AL LAC KG + A ++L+ D G +++T + AL
Sbjct: 906 AVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT-NSALQMP 964
Query: 227 LH 228
LH
Sbjct: 965 LH 966
Score = 93.2 bits (230), Expect = 1e-18
Identities = 65/208 (31%), Positives = 100/208 (48%), Gaps = 1/208 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A + GDV + L A D+ +P H AA+ + L +LLA+ AD+N++++
Sbjct: 48 AAYVGDVP-ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKL 106
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
T LH+A + +C + L ++ + D RS LH A SG +V LL + A L
Sbjct: 107 WQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+V D R PL A+ GH + L+ RGA + D+ L A G EV + LL
Sbjct: 167 NVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Query: 207 SHGADAGAVDSTGHDALHYALHTQDKAL 234
GA+ ++ G+ ALH A + A+
Sbjct: 227 RMGAEIDEPNAFGNTALHIACYLGQDAV 254
Score = 92.4 bits (228), Expect = 2e-18
Identities = 65/192 (33%), Positives = 92/192 (47%), Gaps = 7/192 (3%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANG--ADIN 81
L A RG V L + ++ K +P H AA+ G T+ L +L+ +G ADI
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681
Query: 82 SKNED-GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLC 140
+ G T L LA ++ CV +LL+ G+ DA D R+ LH A +GC + L
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741
Query: 141 DHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNV----TDKNDKSALILACEK 196
DH+AF+ D GRTP+ +AS GH A+ LLQ + D + S + A
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801
Query: 197 GSAEVAELLLSH 208
G + ELLL H
Sbjct: 802 GHEDCLELLLEH 813
Score = 92.0 bits (227), Expect = 2e-18
Identities = 69/220 (31%), Positives = 98/220 (44%), Gaps = 3/220 (1%)
Query: 18 NRHDQKLLEAVHRGDVGR---VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILL 74
N D L +HR R V L SA D Q+P H+AA+ T+C L
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 75 ANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCAS 134
+ +N + G +ALH A S + V +LL GA+ + D + R PLHWAA G
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
Query: 135 SVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILAC 194
+ LL A L D G L A+ G + LL+ GA ++ + +AL +AC
Sbjct: 188 VLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247
Query: 195 EKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKAL 234
G VA L++ GA+ + G LH A + + AL
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL 287
Score = 78.2 bits (191), Expect = 4e-14
Identities = 54/181 (29%), Positives = 87/181 (48%), Gaps = 1/181 (0%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
R A + ++ G + H+A G L+ GA++N N+ G T LH+A +S
Sbjct: 227 RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGA 286
Query: 102 -CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA 160
C+++L+ +GA+ + E +SPLH AA G + +L + + +D D G TPL +A
Sbjct: 287 LCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346
Query: 161 SLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGH 220
+ GH + S L+ GA +D L LA G ++ LLS G V S +
Sbjct: 347 ARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSN 406
Query: 221 D 221
+
Sbjct: 407 E 407
Score = 77.0 bits (188), Expect = 8e-14
Identities = 64/217 (29%), Positives = 89/217 (41%), Gaps = 39/217 (17%)
Query: 47 PTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVL 106
P+ D+ P + K CL LL NGAD + ++ G TA+H A Q +++L
Sbjct: 510 PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
Query: 107 LQHGAN--EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR---------- 154
L+ N ED SPLH AA +G ++ L + LDV D+ GR
Sbjct: 570 LEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERG 629
Query: 155 ------------------------TPLMIASLGGHAAICSQLLQRGARVNVTDKND---K 187
TPL A+ GH L+ G R ++TD D +
Sbjct: 630 STECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
Query: 188 SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
+ L+LA G + LLL G+ A A D G ALH
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH 726
Score = 70.9 bits (172), Expect = 6e-12
Identities = 54/177 (30%), Positives = 79/177 (44%)
Query: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
L Q P A E + LL+ +IN +++ T LH A +++LL
Sbjct: 4 LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
Query: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
GAN +A D +PLH AA+S + LL H A ++ D +TPL +A+
Sbjct: 64 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123
Query: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
L + +NV D++ +SAL A G E LLL+ GA D LH+A
Sbjct: 124 EALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180
Score = 69.3 bits (168), Expect = 2e-11
Identities = 51/159 (32%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
D+ G++ H AAS G ECL +LL++GAD+ +++ G T LH A + QC L+ G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Query: 111 ANEDAVDAENRSPLHWAASSGC--ASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAI 168
A + D + SPLH+AA+S + H+A D + R A
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRK--------EAFF 531
Query: 169 CSQ-LLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
C + LL GA ++ D+ +A+ A G+ + ELLL
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
Score = 67.4 bits (163), Expect = 6e-11
Identities = 55/190 (28%), Positives = 81/190 (42%), Gaps = 27/190 (14%)
Query: 57 PFHLAASKGLTECLTILLANGA------------------DINSKNEDGSTALHLATISC 98
P HLA G ++C LL++G DIN+ + G T LH A
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 99 QPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLM 158
+C+ +LL GA+ D R+PLH+AA++G + L A ++ D G +PL
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL- 493
Query: 159 IASLGGHAAICSQLLQRGA--RVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVD 216
H A S +R + D + L + K + E LL +GAD D
Sbjct: 494 ------HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
Query: 217 STGHDALHYA 226
G+ A+HYA
Sbjct: 548 RQGYTAVHYA 557
Score = 60.8 bits (146), Expect = 6e-09
Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 4/127 (3%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANG-ADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
D G++ AA G T + LL G AD+ +E+ +TALHLA +C ++L
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947
Query: 110 GANEDAVDAENRS---PLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
+ ++A N + PLH AA +G AS V L H A + +D +G TP + +
Sbjct: 948 TQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDV 1007
Query: 167 AICSQLL 173
A C L+
Sbjct: 1008 ADCLALI 1014
Score = 57.8 bits (138), Expect = 5e-08
Identities = 38/103 (36%), Positives = 48/103 (46%), Gaps = 3/103 (2%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD---I 80
L+ A G V L R A T LD N + HLA SKG +C ++LA D I
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Query: 81 NSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSP 123
N+ N LH+A + V+ LL HGA AVD E +P
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 56.6 bits (135), Expect = 1e-07
Identities = 40/127 (31%), Positives = 60/127 (47%)
Query: 103 VKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASL 162
V+ LL N + +D E R+PLH AA G + LL A ++ D TPL A+
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 163 GGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDA 222
+ + LL A VN DK ++ L +A + + AE L + D +G A
Sbjct: 84 SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA 143
Query: 223 LHYALHT 229
LH+A+H+
Sbjct: 144 LHHAVHS 150
Score = 33.9 bits (76), Expect = 0.79
Identities = 22/87 (25%), Positives = 39/87 (44%)
Query: 146 LDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ +L + PL+ A LL + +NV D+ ++ L A G + +LL
Sbjct: 1 MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
Query: 206 LSHGADAGAVDSTGHDALHYALHTQDK 232
L GA+ A D+ LH A ++++
Sbjct: 61 LMSGANVNAKDTLWLTPLHRAAASRNE 87
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 107 bits (267), Expect = 6e-23
Identities = 68/200 (34%), Positives = 95/200 (47%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A H G +VA + K A P NG +P H+A K + + +LL +GA I + E
Sbjct: 374 AAHCGHY-KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTES 432
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T +H+A V L+ HGA+ + + + LH AA SG A V L A +
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ D +TPL I++ G A I QLLQ+GA N + + L L+ +G +VA LL
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL 552
Query: 207 SHGADAGAVDSTGHDALHYA 226
HGA G LH A
Sbjct: 553 DHGASLSITTKKGFTPLHVA 572
Score = 103 bits (258), Expect = 6e-22
Identities = 65/194 (33%), Positives = 99/194 (51%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
+V L + A + +G +P H+AA G ++ L+ +GA N+ N G TALH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
S Q + V+ L+Q GA +A ++++PLH +A G A V L A + G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL +++ GH + + LL GA +++T K + L +A + G EVA LLL A A
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 215 VDSTGHDALHYALH 228
+G LH A H
Sbjct: 594 AGKSGLTPLHVAAH 607
Score = 102 bits (255), Expect = 1e-21
Identities = 68/200 (34%), Positives = 96/200 (48%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A H G++ VA L ++A N +P H+A+ +G + +LL GA I++K D
Sbjct: 242 AAHYGNIN-VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH S Q V++LL A + SPLH A + V LL H +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D + ND T L +A+ GH + LL + A N N + L +AC+K +V ELLL
Sbjct: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
Query: 207 SHGADAGAVDSTGHDALHYA 226
HGA AV +G +H A
Sbjct: 421 KHGASIQAVTESGLTPIHVA 440
Score = 98.6 bits (244), Expect = 3e-20
Identities = 63/200 (31%), Positives = 95/200 (47%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V+ L A P + G++ H+AA G E + L+ +GA + +K +D
Sbjct: 440 AAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
T LH++ + V+ LLQ GA+ +A +PLH +A G L DH A L
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ G + + LLQ+ A + K+ + L +A + +VA LLL
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 207 SHGADAGAVDSTGHDALHYA 226
GA A G+ LH A
Sbjct: 619 DQGASPHAAAKNGYTPLHIA 638
Score = 94.7 bits (234), Expect = 4e-19
Identities = 59/178 (33%), Positives = 92/178 (51%), Gaps = 4/178 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G E ++ LL A++++ + G+TALH+A+++ Q + VKVL+ +G
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A +PL+ AA V L D+ A + DG TPL +A GH + S
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
LL+ + V AL +A K + A LLL + +A +G LH A H
Sbjct: 191 LLLENDTKGKVR----LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244
Score = 94.7 bits (234), Expect = 4e-19
Identities = 58/191 (30%), Positives = 92/191 (48%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L +KSA P +G +P H+AA + +LL GA ++ ++G T LH+A
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
Q LL++GA+ +AV + + +H AA G V LL A +++ + G T
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ + L+ +GA V+ K + L + C G+ ++ LL H A A
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 760 TKNGYTPLHQA 770
Score = 94.0 bits (232), Expect = 6e-19
Identities = 57/172 (33%), Positives = 79/172 (45%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+A C+ +LL + ++ D TALH+A + KVLL AN
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
+A +PLH A + LL H A + + G TP+ +A+ GH I SQL
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQL 452
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
+ GA N T+ ++AL +A G AEV L+ GA A LH
Sbjct: 453 MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
Score = 92.4 bits (228), Expect = 2e-18
Identities = 61/195 (31%), Positives = 89/195 (45%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D +VA L + A P NG +P H+AA K + T LL GAD N+ G ++
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDN 151
HLA V +LL AN + + +PLH AA + +L + A +D
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Query: 152 DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGAD 211
G TPL + G+ I + LLQ A+VN KN + L A ++G + +LL + A
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Query: 212 AGAVDSTGHDALHYA 226
+ G+ AL A
Sbjct: 789 PNELTVNGNTALGIA 803
Score = 90.1 bits (222), Expect = 9e-18
Identities = 62/213 (29%), Positives = 97/213 (45%)
Query: 14 VERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTIL 73
VE + DQ L R + ++ A P ++G +P HL+A +G + L
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 74 LANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCA 133
L +GA ++ + G T LH+A + + +LLQ A+ DA +PLH AA
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
Query: 134 SSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILA 193
LLL D A +G TPL IA+ I + LL+ GA N + +++ LA
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671
Query: 194 CEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
++G ++ LLL A+ + +G LH A
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Score = 88.6 bits (218), Expect = 3e-17
Identities = 54/166 (32%), Positives = 89/166 (53%)
Query: 59 HLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDA 118
H+AA G + +LL A+ N+K +G T LH+A + + +++LL+HGA+ AV
Sbjct: 372 HVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Query: 119 ENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178
+P+H AA G + V L H A + + G T L +A+ G A + L+Q GA+
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 179 VNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
V K+D++ L ++ G A++ + LL GA A ++G+ LH
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Score = 83.2 bits (204), Expect = 1e-15
Identities = 55/170 (32%), Positives = 77/170 (45%)
Query: 59 HLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDA 118
H+AA K T+ +LL N + + +++ G T LH+A +LL A D
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
Query: 119 ENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178
+ +PLH A+ G A+ V LL D A +D DG TPL + GH + LL R A
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Query: 179 VNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ KN S L +A + +LLL H V + ALH A H
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376
Score = 82.8 bits (203), Expect = 1e-15
Identities = 61/193 (31%), Positives = 93/193 (48%), Gaps = 10/193 (5%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
RK +R K S+ + + AA G E + NG DIN N++G ALHLA+ +
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
V LLQ AN DA + + LH A+ +G A V +L + A ++ +G TPL +A+
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGH- 220
H + LL GA ++ ++ + L +A ++G +V LLL + D+ G
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKV 201
Query: 221 --DALHYALHTQD 231
ALH A D
Sbjct: 202 RLPALHIAARKDD 214
Score = 79.0 bits (193), Expect = 2e-14
Identities = 51/152 (33%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G + HLAA +G + +++LL A++N N+ G T LHLA + +VL+ GA+
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH G V L H A ++ +G TPL A+ GH I + LL
Sbjct: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
Q A N N +AL +A G V + L
Sbjct: 784 QNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 61.2 bits (147), Expect = 5e-09
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V+ L R +A + +G +P HLAA + +L+ GA ++++ +
Sbjct: 671 AAQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+ + V LLQH A +A +PLH AA G + +L + A
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQL 172
+ L +G T L IA G+ ++ L
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTL 815
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 106 bits (264), Expect = 1e-22
Identities = 75/209 (35%), Positives = 108/209 (51%), Gaps = 13/209 (6%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
+D+ LL + +G GRV K P K G + +AA KG T + IL++NG D
Sbjct: 121 NDEDLLVRILQG--GRV------KVDVPNKF---GFTALMVAAQKGYTRLVKILVSNGTD 169
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
+N KN G +L LA + VK L +HGA+ A D + LHWAA G S + +
Sbjct: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWM 229
Query: 140 CDHEAFLDVLD-NDGRTPLM-IASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKG 197
+DV+D G TPLM ++++ G+ + S L+ GA VNV D+N K+ L++A
Sbjct: 230 IKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNN 289
Query: 198 SAEVAELLLSHGADAGAVDSTGHDALHYA 226
E+ +LLL GADA + G L A
Sbjct: 290 HEELVQLLLDKGADASVKNEFGKGVLEMA 318
Score = 38.1 bits (87), Expect = 0.042
Identities = 39/175 (22%), Positives = 74/175 (42%), Gaps = 4/175 (2%)
Query: 3 RIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAA 62
+I + T V ++ + D +L A + G + V L R A D G + H AA
Sbjct: 161 KILVSNGTDVNLKNGSGKDSLML-ACYAGHLDVVKYLR-RHGASWQARDLGGCTALHWAA 218
Query: 63 SKGLTECLTILLANGADIN--SKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN 120
G + ++ +G +++ + + ++ +S + +L+ GAN + D
Sbjct: 219 DGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNG 278
Query: 121 RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQR 175
++PL A + V LL D A V + G+ L +A + ++ S L +R
Sbjct: 279 KTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
Score = 36.6 bits (83), Expect = 0.12
Identities = 20/71 (28%), Positives = 43/71 (60%), Gaps = 1/71 (1%)
Query: 171 QLLQRG-ARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHT 229
++LQ G +V+V +K +AL++A +KG + ++L+S+G D + +G D+L A +
Sbjct: 128 RILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYA 187
Query: 230 QDKALWRHLQQ 240
+ ++L++
Sbjct: 188 GHLDVVKYLRR 198
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 106 bits (264), Expect = 1e-22
Identities = 69/194 (35%), Positives = 100/194 (51%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
+V L + A + +G +P H+AA G + +LL NGA + N G TALH+A
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ Q + V+ LL++GA DA E ++PLH A+ G V LL H A D +G
Sbjct: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL I++ G + S LL+ GA ++ K + L +A + GS +VA+LLL A A +
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
Query: 215 VDSTGHDALHYALH 228
G LH A H
Sbjct: 571 AGKNGLTPLHVAAH 584
Score = 104 bits (260), Expect = 4e-22
Identities = 70/200 (35%), Positives = 99/200 (49%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A H G+V VA L + A NG +P H+A+ +G T + +LL G I++K D
Sbjct: 219 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH A S Q V++LL+ GA A SPLH AA V L H+A +
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 337
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D + D T L +A+ GH + LL + A N N + L +AC+K +V ELL+
Sbjct: 338 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 397
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA A+ +G +H A
Sbjct: 398 KYGASIQAITESGLTPIHVA 417
Score = 100 bits (248), Expect = 9e-21
Identities = 66/195 (33%), Positives = 92/195 (47%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D +VA L K A P NG +P H+AA K + + LL GA+ N + G T L
Sbjct: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDN 151
HLA+ V +LL GAN + LH AA + +L H A D
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705
Query: 152 DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGAD 211
G TPL++A G+ + + LL++GA VN KN + L A ++G + +LL HGA
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Query: 212 AGAVDSTGHDALHYA 226
A + G+ AL A
Sbjct: 766 PNATTANGNTALAIA 780
Score = 94.0 bits (232), Expect = 6e-19
Identities = 60/191 (31%), Positives = 93/191 (48%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
+ L + A P + G++ H+AA G E + LL NGA ++++ + T LH+A+
Sbjct: 425 IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 484
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + V++LLQH A+ DA +PLH +A G +L + A + G T
Sbjct: 485 RLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 544
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ G + LLQR A + KN + L +A + +VA LLL GA A
Sbjct: 545 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 605 AKNGYTPLHIA 615
Score = 93.2 bits (230), Expect = 1e-18
Identities = 58/193 (30%), Positives = 95/193 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA++ A + G +P H+AA G + +LL A +S ++G T LH+A
Sbjct: 524 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ +LL+ GA+ A +PLH AA L ++ A +++ G T
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +AS GH + + LL +GA ++++ K+ ++L LA ++ VA++L HGAD A
Sbjct: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 703
Query: 216 DSTGHDALHYALH 228
G+ L A H
Sbjct: 704 TKLGYTPLIVACH 716
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/208 (30%), Positives = 93/208 (44%)
Query: 19 RHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGA 78
R +Q L R + L + A P +NG +P H++A +G + ++LL GA
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 79 DINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLL 138
+ + G T LH+A K+LLQ A D+ +PLH AA LL
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593
Query: 139 LCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGS 198
L + A +G TPL IA+ I S LL GA N+ K + L LA ++G
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
++ LLL GA+ +G +LH A
Sbjct: 654 TDMVTLLLDKGANIHMSTKSGLTSLHLA 681
Score = 90.1 bits (222), Expect = 9e-18
Identities = 58/191 (30%), Positives = 88/191 (46%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L ++ A NG +P H+AA + +LL GA ++ ++G T LH+A
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 616
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
Q Q LL +GA + V + +PLH A+ G V LL D A + + G T
Sbjct: 617 KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 676
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
L +A+ + L + GA + K + LI+AC G+ ++ LL GA+ A
Sbjct: 677 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 736
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 737 TKNGYTPLHQA 747
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/171 (32%), Positives = 85/171 (49%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
++A+ A + G +P HLA+ +G T+ +T+LL GA+I+ + G T+LHLA
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ +L +HGA++DA +PL A G V L A ++ +G
Sbjct: 682 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 741
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
TPL A+ GH I + LLQ GA+ N T N +AL +A G V + L
Sbjct: 742 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/202 (31%), Positives = 89/202 (44%)
Query: 25 LEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKN 84
L R +V L + A NG SP H+AA EC+ LL + A ++
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Query: 85 EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
D TALH+A + K+LL AN +A +PLH A + LL + A
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
+ + G TP+ +A+ GH I LLQ GA +VT+ ++AL +A G EV
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL +GA A LH A
Sbjct: 462 LLRNGALVDARAREEQTPLHIA 483
Score = 84.7 bits (208), Expect = 4e-16
Identities = 69/213 (32%), Positives = 91/213 (42%), Gaps = 13/213 (6%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN--GADIN 81
L A+ +G VA L + +L + H+AA K T+ +LL N AD+
Sbjct: 146 LAVALQQGHNQAVAILLENDTKGKVRLPA-----LHIAARKDDTKSAALLLQNDHNADVQ 200
Query: 82 SK------NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASS 135
SK E G T LH+A +LL GA D +PLH A+ G +
Sbjct: 201 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 260
Query: 136 VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACE 195
V LL D +D DG TPL A+ GH + LL+RGA + KN S L +A +
Sbjct: 261 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ 320
Query: 196 KGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
E + LL H A V ALH A H
Sbjct: 321 GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353
Score = 84.7 bits (208), Expect = 4e-16
Identities = 65/203 (32%), Positives = 91/203 (44%), Gaps = 8/203 (3%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
LL+ H DV + + +G +P H+AA G T+LL GA ++
Sbjct: 190 LLQNDHNADV--------QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+G T LH+A+ VK+LL G DA + +PLH AA SG V LL +
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 301
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE 203
A L +G +PL +A+ G H LLQ A V+ + +AL +A G V +
Sbjct: 302 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 361
Query: 204 LLLSHGADAGAVDSTGHDALHYA 226
LLL A+ A G LH A
Sbjct: 362 LLLDKRANPNARALNGFTPLHIA 384
Score = 84.0 bits (206), Expect = 7e-16
Identities = 61/200 (30%), Positives = 91/200 (45%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A RG+ V L R K +G +P H AA G + + +LL GA + ++ ++
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G + LH+A +CVK LLQH A D V + + LH AA G LL D A
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ +G TPL IA + L++ GA + ++ + + +A G + LLL
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 430
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA + G ALH A
Sbjct: 431 QNGASPDVTNIRGETALHMA 450
Score = 83.6 bits (205), Expect = 9e-16
Identities = 60/186 (32%), Positives = 88/186 (47%), Gaps = 12/186 (6%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLAA +G + LL G+ ++S + G+TALH+A+++ Q + VKVL++ G
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A +PL+ AA V L ++ A DG TPL +A GH +
Sbjct: 100 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL--SHGAD------AGAVDSTGHDA 222
LL+ + V AL +A K + A LLL H AD +G
Sbjct: 160 ILLENDTKGKVR----LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215
Query: 223 LHYALH 228
LH A H
Sbjct: 216 LHIAAH 221
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/242 (26%), Positives = 99/242 (40%), Gaps = 37/242 (15%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
V + ++ A NG +P ++AA + + + LL NGA+ ++ EDG T L +A
Sbjct: 91 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 150
Query: 96 ISCQPQCVKVLLQHGA--------------------------NEDAVDAENR-------- 121
Q V +LL++ N+ D +++
Sbjct: 151 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
Query: 122 ---SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178
+PLH AA G + LL + A +D +G TPL +AS G+ + LL RG +
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 179 VNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHL 238
++ ++ + L A G +V ELLL GA A G LH A +HL
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Query: 239 QQ 240
Q
Sbjct: 331 LQ 332
Score = 70.9 bits (172), Expect = 6e-12
Identities = 55/186 (29%), Positives = 87/186 (46%), Gaps = 12/186 (6%)
Query: 49 KLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQ 108
K DSN F AA G + + L G DIN+ N++G ALHLA V+ LL
Sbjct: 7 KSDSNAS--FLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 109 HGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAI 168
G++ D+ + + LH A+ +G A V +L A ++ +G TPL +A+ H +
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 169 CSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGH---DALHY 225
LL+ GA + ++ + L +A ++G + +LL + D+ G ALH
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHI 177
Query: 226 ALHTQD 231
A D
Sbjct: 178 AARKDD 183
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/105 (31%), Positives = 48/105 (45%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D VA + ++ A G +P +A G + + LL GA++N+K ++G T L
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
H A + VLLQHGA +A A + L A G S V
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 106 bits (264), Expect = 1e-22
Identities = 69/194 (35%), Positives = 100/194 (51%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
+V L + A + +G +P H+AA G + +LL NGA + N G TALH+A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ Q + V+ LL++GA DA E ++PLH A+ G V LL H A D +G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL I++ G + S LL+ GA ++ K + L +A + GS +VA+LLL A A +
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 215 VDSTGHDALHYALH 228
G LH A H
Sbjct: 592 AGKNGLTPLHVAAH 605
Score = 104 bits (260), Expect = 4e-22
Identities = 70/200 (35%), Positives = 99/200 (49%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A H G+V VA L + A NG +P H+A+ +G T + +LL G I++K D
Sbjct: 240 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH A S Q V++LL+ GA A SPLH AA V L H+A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D + D T L +A+ GH + LL + A N N + L +AC+K +V ELL+
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA A+ +G +H A
Sbjct: 419 KYGASIQAITESGLTPIHVA 438
Score = 100 bits (248), Expect = 9e-21
Identities = 66/195 (33%), Positives = 92/195 (47%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D +VA L K A P NG +P H+AA K + + LL GA+ N + G T L
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDN 151
HLA+ V +LL GAN + LH AA + +L H A D
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 152 DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGAD 211
G TPL++A G+ + + LL++GA VN KN + L A ++G + +LL HGA
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 212 AGAVDSTGHDALHYA 226
A + G+ AL A
Sbjct: 787 PNATTANGNTALAIA 801
Score = 94.0 bits (232), Expect = 6e-19
Identities = 60/191 (31%), Positives = 93/191 (48%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
+ L + A P + G++ H+AA G E + LL NGA ++++ + T LH+A+
Sbjct: 446 IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + V++LLQH A+ DA +PLH +A G +L + A + G T
Sbjct: 506 RLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 565
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ G + LLQR A + KN + L +A + +VA LLL GA A
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 626 AKNGYTPLHIA 636
Score = 93.2 bits (230), Expect = 1e-18
Identities = 58/193 (30%), Positives = 95/193 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA++ A + G +P H+AA G + +LL A +S ++G T LH+A
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ +LL+ GA+ A +PLH AA L ++ A +++ G T
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +AS GH + + LL +GA ++++ K+ ++L LA ++ VA++L HGAD A
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
Query: 216 DSTGHDALHYALH 228
G+ L A H
Sbjct: 725 TKLGYTPLIVACH 737
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/208 (30%), Positives = 93/208 (44%)
Query: 19 RHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGA 78
R +Q L R + L + A P +NG +P H++A +G + ++LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 79 DINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLL 138
+ + G T LH+A K+LLQ A D+ +PLH AA LL
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
Query: 139 LCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGS 198
L + A +G TPL IA+ I S LL GA N+ K + L LA ++G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
++ LLL GA+ +G +LH A
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Score = 90.1 bits (222), Expect = 9e-18
Identities = 58/191 (30%), Positives = 88/191 (46%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L ++ A NG +P H+AA + +LL GA ++ ++G T LH+A
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
Q Q LL +GA + V + +PLH A+ G V LL D A + + G T
Sbjct: 638 KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 697
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
L +A+ + L + GA + K + LI+AC G+ ++ LL GA+ A
Sbjct: 698 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 758 TKNGYTPLHQA 768
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/171 (32%), Positives = 85/171 (49%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
++A+ A + G +P HLA+ +G T+ +T+LL GA+I+ + G T+LHLA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ +L +HGA++DA +PL A G V L A ++ +G
Sbjct: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
TPL A+ GH I + LLQ GA+ N T N +AL +A G V + L
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/202 (31%), Positives = 89/202 (44%)
Query: 25 LEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKN 84
L R +V L + A NG SP H+AA EC+ LL + A ++
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 85 EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
D TALH+A + K+LL AN +A +PLH A + LL + A
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
+ + G TP+ +A+ GH I LLQ GA +VT+ ++AL +A G EV
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL +GA A LH A
Sbjct: 483 LLRNGALVDARAREEQTPLHIA 504
Score = 84.7 bits (208), Expect = 4e-16
Identities = 69/213 (32%), Positives = 91/213 (42%), Gaps = 13/213 (6%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN--GADIN 81
L A+ +G VA L + +L + H+AA K T+ +LL N AD+
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPA-----LHIAARKDDTKSAALLLQNDHNADVQ 221
Query: 82 SK------NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASS 135
SK E G T LH+A +LL GA D +PLH A+ G +
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 281
Query: 136 VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACE 195
V LL D +D DG TPL A+ GH + LL+RGA + KN S L +A +
Sbjct: 282 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
Query: 196 KGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
E + LL H A V ALH A H
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374
Score = 84.7 bits (208), Expect = 4e-16
Identities = 65/203 (32%), Positives = 91/203 (44%), Gaps = 8/203 (3%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
LL+ H DV + + +G +P H+AA G T+LL GA ++
Sbjct: 211 LLQNDHNADV--------QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+G T LH+A+ VK+LL G DA + +PLH AA SG V LL +
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE 203
A L +G +PL +A+ G H LLQ A V+ + +AL +A G V +
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382
Query: 204 LLLSHGADAGAVDSTGHDALHYA 226
LLL A+ A G LH A
Sbjct: 383 LLLDKRANPNARALNGFTPLHIA 405
Score = 84.0 bits (206), Expect = 7e-16
Identities = 61/200 (30%), Positives = 91/200 (45%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A RG+ V L R K +G +P H AA G + + +LL GA + ++ ++
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G + LH+A +CVK LLQH A D V + + LH AA G LL D A
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ +G TPL IA + L++ GA + ++ + + +A G + LLL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA + G ALH A
Sbjct: 452 QNGASPDVTNIRGETALHMA 471
Score = 83.6 bits (205), Expect = 9e-16
Identities = 60/186 (32%), Positives = 88/186 (47%), Gaps = 12/186 (6%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLAA +G + LL G+ ++S + G+TALH+A+++ Q + VKVL++ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A +PL+ AA V L ++ A DG TPL +A GH +
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL--SHGAD------AGAVDSTGHDA 222
LL+ + V AL +A K + A LLL H AD +G
Sbjct: 181 ILLENDTKGKVR----LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 223 LHYALH 228
LH A H
Sbjct: 237 LHIAAH 242
Score = 80.5 bits (197), Expect = 7e-15
Identities = 61/209 (29%), Positives = 98/209 (46%), Gaps = 12/209 (5%)
Query: 26 EAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNE 85
+A + D G +S++ RP K DSN F AA G + + L G DIN+ N+
Sbjct: 5 DAAQKSDSGEKFNGSSQRRKRPKKSDSNAS--FLRAARAGNLDKVVEYLKGGIDINTCNQ 62
Query: 86 DGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAF 145
+G ALHLA V+ LL G++ D+ + + LH A+ +G A V +L A
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 146 LDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
++ +G TPL +A+ H + LL+ GA + ++ + L +A ++G + +L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 206 LSHGADAGAVDSTGH---DALHYALHTQD 231
L + D+ G ALH A D
Sbjct: 183 LEN-------DTKGKVRLPALHIAARKDD 204
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/242 (26%), Positives = 99/242 (40%), Gaps = 37/242 (15%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
V + ++ A NG +P ++AA + + + LL NGA+ ++ EDG T L +A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 96 ISCQPQCVKVLLQHGA--------------------------NEDAVDAENR-------- 121
Q V +LL++ N+ D +++
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 122 ---SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178
+PLH AA G + LL + A +D +G TPL +AS G+ + LL RG +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 179 VNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHL 238
++ ++ + L A G +V ELLL GA A G LH A +HL
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 239 QQ 240
Q
Sbjct: 352 LQ 353
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/105 (31%), Positives = 48/105 (45%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D VA + ++ A G +P +A G + + LL GA++N+K ++G T L
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
H A + VLLQHGA +A A + L A G S V
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 106 bits (264), Expect = 1e-22
Identities = 69/194 (35%), Positives = 100/194 (51%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
+V L + A + +G +P H+AA G + +LL NGA + N G TALH+A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ Q + V+ LL++GA DA E ++PLH A+ G V LL H A D +G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL I++ G + S LL+ GA ++ K + L +A + GS +VA+LLL A A +
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 215 VDSTGHDALHYALH 228
G LH A H
Sbjct: 592 AGKNGLTPLHVAAH 605
Score = 104 bits (260), Expect = 4e-22
Identities = 70/200 (35%), Positives = 99/200 (49%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A H G+V VA L + A NG +P H+A+ +G T + +LL G I++K D
Sbjct: 240 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH A S Q V++LL+ GA A SPLH AA V L H+A +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D + D T L +A+ GH + LL + A N N + L +AC+K +V ELL+
Sbjct: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA A+ +G +H A
Sbjct: 419 KYGASIQAITESGLTPIHVA 438
Score = 100 bits (248), Expect = 9e-21
Identities = 66/195 (33%), Positives = 92/195 (47%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D +VA L K A P NG +P H+AA K + + LL GA+ N + G T L
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDN 151
HLA+ V +LL GAN + LH AA + +L H A D
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 152 DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGAD 211
G TPL++A G+ + + LL++GA VN KN + L A ++G + +LL HGA
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 212 AGAVDSTGHDALHYA 226
A + G+ AL A
Sbjct: 787 PNATTANGNTALAIA 801
Score = 94.0 bits (232), Expect = 6e-19
Identities = 60/191 (31%), Positives = 93/191 (48%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
+ L + A P + G++ H+AA G E + LL NGA ++++ + T LH+A+
Sbjct: 446 IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + V++LLQH A+ DA +PLH +A G +L + A + G T
Sbjct: 506 RLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 565
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ G + LLQR A + KN + L +A + +VA LLL GA A
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 626 AKNGYTPLHIA 636
Score = 93.2 bits (230), Expect = 1e-18
Identities = 58/193 (30%), Positives = 95/193 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA++ A + G +P H+AA G + +LL A +S ++G T LH+A
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ +LL+ GA+ A +PLH AA L ++ A +++ G T
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +AS GH + + LL +GA ++++ K+ ++L LA ++ VA++L HGAD A
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
Query: 216 DSTGHDALHYALH 228
G+ L A H
Sbjct: 725 TKLGYTPLIVACH 737
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/208 (30%), Positives = 93/208 (44%)
Query: 19 RHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGA 78
R +Q L R + L + A P +NG +P H++A +G + ++LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 79 DINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLL 138
+ + G T LH+A K+LLQ A D+ +PLH AA LL
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
Query: 139 LCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGS 198
L + A +G TPL IA+ I S LL GA N+ K + L LA ++G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 199 AEVAELLLSHGADAGAVDSTGHDALHYA 226
++ LLL GA+ +G +LH A
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Score = 90.1 bits (222), Expect = 9e-18
Identities = 58/191 (30%), Positives = 88/191 (46%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L ++ A NG +P H+AA + +LL GA ++ ++G T LH+A
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
Q Q LL +GA + V + +PLH A+ G V LL D A + + G T
Sbjct: 638 KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 697
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
L +A+ + L + GA + K + LI+AC G+ ++ LL GA+ A
Sbjct: 698 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 216 DSTGHDALHYA 226
G+ LH A
Sbjct: 758 TKNGYTPLHQA 768
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/171 (32%), Positives = 85/171 (49%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
++A+ A + G +P HLA+ +G T+ +T+LL GA+I+ + G T+LHLA
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
+ +L +HGA++DA +PL A G V L A ++ +G
Sbjct: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
TPL A+ GH I + LLQ GA+ N T N +AL +A G V + L
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/202 (31%), Positives = 89/202 (44%)
Query: 25 LEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKN 84
L R +V L + A NG SP H+AA EC+ LL + A ++
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 85 EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
D TALH+A + K+LL AN +A +PLH A + LL + A
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
+ + G TP+ +A+ GH I LLQ GA +VT+ ++AL +A G EV
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL +GA A LH A
Sbjct: 483 LLRNGALVDARAREEQTPLHIA 504
Score = 84.7 bits (208), Expect = 4e-16
Identities = 69/213 (32%), Positives = 91/213 (42%), Gaps = 13/213 (6%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN--GADIN 81
L A+ +G VA L + +L + H+AA K T+ +LL N AD+
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPA-----LHIAARKDDTKSAALLLQNDHNADVQ 221
Query: 82 SK------NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASS 135
SK E G T LH+A +LL GA D +PLH A+ G +
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 281
Query: 136 VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACE 195
V LL D +D DG TPL A+ GH + LL+RGA + KN S L +A +
Sbjct: 282 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
Query: 196 KGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
E + LL H A V ALH A H
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374
Score = 84.7 bits (208), Expect = 4e-16
Identities = 65/203 (32%), Positives = 91/203 (44%), Gaps = 8/203 (3%)
Query: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
LL+ H DV + + +G +P H+AA G T+LL GA ++
Sbjct: 211 LLQNDHNADV--------QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 84 NEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHE 143
+G T LH+A+ VK+LL G DA + +PLH AA SG V LL +
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Query: 144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE 203
A L +G +PL +A+ G H LLQ A V+ + +AL +A G V +
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382
Query: 204 LLLSHGADAGAVDSTGHDALHYA 226
LLL A+ A G LH A
Sbjct: 383 LLLDKRANPNARALNGFTPLHIA 405
Score = 84.0 bits (206), Expect = 7e-16
Identities = 61/200 (30%), Positives = 91/200 (45%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A RG+ V L R K +G +P H AA G + + +LL GA + ++ ++
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G + LH+A +CVK LLQH A D V + + LH AA G LL D A
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ +G TPL IA + L++ GA + ++ + + +A G + LLL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA + G ALH A
Sbjct: 452 QNGASPDVTNIRGETALHMA 471
Score = 83.6 bits (205), Expect = 9e-16
Identities = 60/186 (32%), Positives = 88/186 (47%), Gaps = 12/186 (6%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLAA +G + LL G+ ++S + G+TALH+A+++ Q + VKVL++ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A +PL+ AA V L ++ A DG TPL +A GH +
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL--SHGAD------AGAVDSTGHDA 222
LL+ + V AL +A K + A LLL H AD +G
Sbjct: 181 ILLENDTKGKVR----LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 223 LHYALH 228
LH A H
Sbjct: 237 LHIAAH 242
Score = 80.5 bits (197), Expect = 7e-15
Identities = 61/209 (29%), Positives = 98/209 (46%), Gaps = 12/209 (5%)
Query: 26 EAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNE 85
+A + D G +S++ RP K DSN F AA G + + L G DIN+ N+
Sbjct: 5 DAAQKSDSGEKFNGSSQRRKRPKKSDSNAS--FLRAARAGNLDKVVEYLKGGIDINTCNQ 62
Query: 86 DGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAF 145
+G ALHLA V+ LL G++ D+ + + LH A+ +G A V +L A
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 146 LDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELL 205
++ +G TPL +A+ H + LL+ GA + ++ + L +A ++G + +L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 206 LSHGADAGAVDSTGH---DALHYALHTQD 231
L + D+ G ALH A D
Sbjct: 183 LEN-------DTKGKVRLPALHIAARKDD 204
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/242 (26%), Positives = 99/242 (40%), Gaps = 37/242 (15%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
V + ++ A NG +P ++AA + + + LL NGA+ ++ EDG T L +A
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 96 ISCQPQCVKVLLQHGA--------------------------NEDAVDAENR-------- 121
Q V +LL++ N+ D +++
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 122 ---SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178
+PLH AA G + LL + A +D +G TPL +AS G+ + LL RG +
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 179 VNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHL 238
++ ++ + L A G +V ELLL GA A G LH A +HL
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 239 QQ 240
Q
Sbjct: 352 LQ 353
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/105 (31%), Positives = 48/105 (45%)
Query: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTAL 91
D VA + ++ A G +P +A G + + LL GA++N+K ++G T L
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 92 HLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
H A + VLLQHGA +A A + L A G S V
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 105 bits (263), Expect = 2e-22
Identities = 67/191 (35%), Positives = 94/191 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L + A NG +P H+A+ +G + +LL GA I +K +D T LH A
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + ++LL HGA A SP+H AA V LL ++A +D + D T
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 373
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH + LL +GA+ N N + L +AC+K V ELLL GA AV
Sbjct: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
Query: 216 DSTGHDALHYA 226
+G LH A
Sbjct: 434 TESGLTPLHVA 444
Score = 102 bits (254), Expect = 2e-21
Identities = 60/192 (31%), Positives = 94/192 (48%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
RVA L + A P NG +P H+A + + +LL G +S +G T LH+A
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
Q + + LLQ+G + +A + +PLH AA G A V LL +A ++ + G
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL + + GH + L++ G V+ T + + L +A G+ ++ + LL H AD A
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 215 VDSTGHDALHYA 226
G+ LH A
Sbjct: 763 KTKLGYSPLHQA 774
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/199 (31%), Positives = 93/199 (46%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
++ A P + ++P H+AA G TE LL N A +N+K +D T LH A
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
VK+LL++ AN + +PLH AA G +VL L + EA + G TPL +A+
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
G + LL+R A N KN + L +A + ++ +LLL G + G+
Sbjct: 578 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637
Query: 222 ALHYALHTQDKALWRHLQQ 240
LH A + R L Q
Sbjct: 638 PLHIAAKQNQVEVARSLLQ 656
Score = 95.1 bits (235), Expect = 3e-19
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 1/207 (0%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
H L A H G RVA + K A+P NG +P H+A K + +LL GA
Sbjct: 371 HLTPLHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
I++ E G T LH+A+ VK LLQ GA+ + + + +PLH AA +G L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 140 CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
++A ++ D +TPL A+ GH + LL+ A N+ + L +A +G
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E LL A + G LH A
Sbjct: 550 ETVLALLEKEASQACMTKKGFTPLHVA 576
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/174 (35%), Positives = 83/174 (47%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+AA +C+ +LL A+I+ D T LH+A + KVLL GA
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
++ +PLH A + LL A +D + G TPL +AS GH I L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LQRGA NV++ ++ L +A G EVA+ LL + A A LH A
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/200 (32%), Positives = 89/200 (44%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
AVH ++ V L R + P NG +P H+AA + E LL G N+++
Sbjct: 609 AVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA + V +LL AN + + +PLH A G +L H +
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D G TPL +AS G+ + LLQ A VN K S L A ++G ++ LLL
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA V S G L A
Sbjct: 788 KNGASPNEVSSDGTTPLAIA 807
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 15/254 (5%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V AL +++++ + G +P H+AA G +LL A N+ ++
Sbjct: 543 AAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 601
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+LL G + + +PLH AA L +
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ GHA + + LL + A N+ +K+ + L L ++G VA++L+
Sbjct: 662 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721
Query: 207 SHGADAGAVDSTGHDALHYALHTQD----KALWRHLQQALSRRRRGGQRLVQ-----HPD 257
HG A G+ LH A H + K L +H ++ + G L Q H D
Sbjct: 722 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 781
Query: 258 -----LASQASPSE 266
L + ASP+E
Sbjct: 782 IVTLLLKNGASPNE 795
Score = 83.2 bits (204), Expect = 1e-15
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 29/202 (14%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGST------------------------ 89
G +P ++AA + E + LL NGA+ N EDG T
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
Query: 90 -----ALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
ALH+A + + VLLQ+ N D + +PLH AA + LL + A
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +G TPL IAS G+ + LL RGA++ K++ + L A G ++E+
Sbjct: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 323
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL HGA A G +H A
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMA 345
Score = 82.8 bits (203), Expect = 1e-15
Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G + + LL + + + G+TALH+A ++ Q + V+ L+ +G
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A + +PL+ AA V L ++ A +V DG TPL +A GH + +
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 194
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
L+ G + V AL +A A +LL + + + TG LH A H +
Sbjct: 195 HLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 250
Query: 231 D 231
+
Sbjct: 251 N 251
Score = 80.1 bits (196), Expect = 1e-14
Identities = 58/191 (30%), Positives = 85/191 (44%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA + A+ + Q+P H AA G T + +LL N A+ N G T LH+A
Sbjct: 485 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 544
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ V LL+ A++ + + +PLH AA G LL + +A + +G T
Sbjct: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 604
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A + I LL RG + N + L +A ++ EVA LL +G A A
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 216 DSTGHDALHYA 226
G LH A
Sbjct: 665 SVQGVTPLHLA 675
Score = 78.2 bits (191), Expect = 4e-14
Identities = 50/152 (32%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA +G E + +LL+ A+ N N+ G T LHL VL++HG
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH A+ G V L H+A ++ G +PL A+ GH I + LL
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ GA N + + L +A G V ++L
Sbjct: 788 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 17/219 (7%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTEC 69
T +AV H+ + ++ G G+V A H+AA T
Sbjct: 179 TPLAVALQQGHENVVAHLINYGTKGKVRLPA-----------------LHIAARNDDTRT 221
Query: 70 LTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
+LL N + + ++ G T LH+A ++LL GA+ + +PLH A+
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
Query: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSA 189
G V LL D A ++ D TPL A+ GH I LL GA + KN S
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
Query: 190 LILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ +A + + LLL + A+ + LH A H
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380
Score = 72.4 bits (176), Expect = 2e-12
Identities = 74/271 (27%), Positives = 117/271 (43%), Gaps = 22/271 (8%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G VA L S K A + +G +P HL A +G +L+ +G +++
Sbjct: 675 AAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 733
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A+ + VK LLQH A+ +A SPLH AA G V LL + A
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK---GSAEVAE 203
+ + +DG TPL IA G+ ++ L D+++ +L +K E +
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISVTDVL---------KVVTDETSFVLVSDKHRMSFPETVD 844
Query: 204 LLLSHGADAGAVDST--GHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQ 261
+L D G T G + + + +D ++ L + Q +V+ P
Sbjct: 845 EILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQ-VVESP----- 898
Query: 262 ASPSEPQAGSPPKSSWRAEPEEEQEEKEDED 292
A P P A P R+E +E+ ++ DED
Sbjct: 899 AIPRIPCA-MPETVVIRSEEQEQASKEYDED 928
Score = 60.8 bits (146), Expect = 6e-09
Identities = 50/197 (25%), Positives = 75/197 (38%), Gaps = 33/197 (16%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
R +R K ++ + F AA G + L NG DIN+ N++G LHL
Sbjct: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHL-------- 84
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
A+ G V+ L E L+ G T L IA+
Sbjct: 85 -------------------------ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAA 119
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
L G + +L+ GA VN + + L +A ++ EV + LL +GA+ G
Sbjct: 120 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 179
Query: 222 ALHYALHTQDKALWRHL 238
L AL + + HL
Sbjct: 180 PLAVALQQGHENVVAHL 196
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 105 bits (263), Expect = 2e-22
Identities = 67/191 (35%), Positives = 94/191 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L + A NG +P H+A+ +G + +LL GA I +K +D T LH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + ++LL HGA A SP+H AA V LL ++A +D + D T
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH + LL +GA+ N N + L +AC+K V ELLL GA AV
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 216 DSTGHDALHYA 226
+G LH A
Sbjct: 401 TESGLTPLHVA 411
Score = 102 bits (254), Expect = 2e-21
Identities = 60/192 (31%), Positives = 94/192 (48%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
RVA L + A P NG +P H+A + + +LL G +S +G T LH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
Q + + LLQ+G + +A + +PLH AA G A V LL +A ++ + G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL + + GH + L++ G V+ T + + L +A G+ ++ + LL H AD A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 215 VDSTGHDALHYA 226
G+ LH A
Sbjct: 730 KTKLGYSPLHQA 741
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/199 (31%), Positives = 93/199 (46%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
++ A P + ++P H+AA G TE LL N A +N+K +D T LH A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
VK+LL++ AN + +PLH AA G +VL L + EA + G TPL +A+
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
G + LL+R A N KN + L +A + ++ +LLL G + G+
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 222 ALHYALHTQDKALWRHLQQ 240
LH A + R L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 95.1 bits (235), Expect = 3e-19
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 1/207 (0%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
H L A H G RVA + K A+P NG +P H+A K + +LL GA
Sbjct: 338 HLTPLHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
I++ E G T LH+A+ VK LLQ GA+ + + + +PLH AA +G L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 140 CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
++A ++ D +TPL A+ GH + LL+ A N+ + L +A +G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E LL A + G LH A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/174 (35%), Positives = 83/174 (47%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+AA +C+ +LL A+I+ D T LH+A + KVLL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
++ +PLH A + LL A +D + G TPL +AS GH I L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LQRGA NV++ ++ L +A G EVA+ LL + A A LH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/200 (32%), Positives = 89/200 (44%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
AVH ++ V L R + P NG +P H+AA + E LL G N+++
Sbjct: 576 AVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA + V +LL AN + + +PLH A G +L H +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D G TPL +AS G+ + LLQ A VN K S L A ++G ++ LLL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA V S G L A
Sbjct: 755 KNGASPNEVSSDGTTPLAIA 774
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 15/254 (5%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V AL +++++ + G +P H+AA G +LL A N+ ++
Sbjct: 510 AAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+LL G + + +PLH AA L +
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ GHA + + LL + A N+ +K+ + L L ++G VA++L+
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 SHGADAGAVDSTGHDALHYALHTQD----KALWRHLQQALSRRRRGGQRLVQ-----HPD 257
HG A G+ LH A H + K L +H ++ + G L Q H D
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 258 -----LASQASPSE 266
L + ASP+E
Sbjct: 749 IVTLLLKNGASPNE 762
Score = 83.2 bits (204), Expect = 1e-15
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 29/202 (14%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGST------------------------ 89
G +P ++AA + E + LL NGA+ N EDG T
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 90 -----ALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
ALH+A + + VLLQ+ N D + +PLH AA + LL + A
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +G TPL IAS G+ + LL RGA++ K++ + L A G ++E+
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL HGA A G +H A
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMA 312
Score = 82.8 bits (203), Expect = 1e-15
Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G + + LL + + + G+TALH+A ++ Q + V+ L+ +G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A + +PL+ AA V L ++ A +V DG TPL +A GH + +
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
L+ G + V AL +A A +LL + + + TG LH A H +
Sbjct: 162 HLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 231 D 231
+
Sbjct: 218 N 218
Score = 80.1 bits (196), Expect = 1e-14
Identities = 58/191 (30%), Positives = 85/191 (44%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA + A+ + Q+P H AA G T + +LL N A+ N G T LH+A
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ V LL+ A++ + + +PLH AA G LL + +A + +G T
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A + I LL RG + N + L +A ++ EVA LL +G A A
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 216 DSTGHDALHYA 226
G LH A
Sbjct: 632 SVQGVTPLHLA 642
Score = 78.2 bits (191), Expect = 4e-14
Identities = 50/152 (32%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA +G E + +LL+ A+ N N+ G T LHL VL++HG
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH A+ G V L H+A ++ G +PL A+ GH I + LL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ GA N + + L +A G V ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 17/219 (7%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTEC 69
T +AV H+ + ++ G G+V A H+AA T
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVRLPA-----------------LHIAARNDDTRT 188
Query: 70 LTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
+LL N + + ++ G T LH+A ++LL GA+ + +PLH A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSA 189
G V LL D A ++ D TPL A+ GH I LL GA + KN S
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 190 LILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ +A + + LLL + A+ + LH A H
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 70.5 bits (171), Expect = 8e-12
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G VA L S K A + +G +P HL A +G +L+ +G +++
Sbjct: 642 AAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A+ + VK LLQH A+ +A SPLH AA G V LL + A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQL 172
+ + +DG TPL IA G+ ++ L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/188 (25%), Positives = 72/188 (38%), Gaps = 33/188 (17%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+++ + F AA G + L NG DIN+ N++G LHL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHL----------------- 51
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
A+ G V+ L E L+ G T L IA+L G +
Sbjct: 52 ----------------ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
+L+ GA VN + + L +A ++ EV + LL +GA+ G L AL
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 231 DKALWRHL 238
+ + HL
Sbjct: 156 HENVVAHL 163
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 105 bits (263), Expect = 2e-22
Identities = 67/191 (35%), Positives = 94/191 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L + A NG +P H+A+ +G + +LL GA I +K +D T LH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + ++LL HGA A SP+H AA V LL ++A +D + D T
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH + LL +GA+ N N + L +AC+K V ELLL GA AV
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 216 DSTGHDALHYA 226
+G LH A
Sbjct: 401 TESGLTPLHVA 411
Score = 102 bits (254), Expect = 2e-21
Identities = 60/192 (31%), Positives = 94/192 (48%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
RVA L + A P NG +P H+A + + +LL G +S +G T LH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
Q + + LLQ+G + +A + +PLH AA G A V LL +A ++ + G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL + + GH + L++ G V+ T + + L +A G+ ++ + LL H AD A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 215 VDSTGHDALHYA 226
G+ LH A
Sbjct: 730 KTKLGYSPLHQA 741
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/199 (31%), Positives = 93/199 (46%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
++ A P + ++P H+AA G TE LL N A +N+K +D T LH A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
VK+LL++ AN + +PLH AA G +VL L + EA + G TPL +A+
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
G + LL+R A N KN + L +A + ++ +LLL G + G+
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 222 ALHYALHTQDKALWRHLQQ 240
LH A + R L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 95.1 bits (235), Expect = 3e-19
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 1/207 (0%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
H L A H G RVA + K A+P NG +P H+A K + +LL GA
Sbjct: 338 HLTPLHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
I++ E G T LH+A+ VK LLQ GA+ + + + +PLH AA +G L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 140 CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
++A ++ D +TPL A+ GH + LL+ A N+ + L +A +G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E LL A + G LH A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/174 (35%), Positives = 83/174 (47%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+AA +C+ +LL A+I+ D T LH+A + KVLL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
++ +PLH A + LL A +D + G TPL +AS GH I L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LQRGA NV++ ++ L +A G EVA+ LL + A A LH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/200 (32%), Positives = 89/200 (44%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
AVH ++ V L R + P NG +P H+AA + E LL G N+++
Sbjct: 576 AVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA + V +LL AN + + +PLH A G +L H +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D G TPL +AS G+ + LLQ A VN K S L A ++G ++ LLL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA V S G L A
Sbjct: 755 KNGASPNEVSSDGTTPLAIA 774
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 15/254 (5%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V AL +++++ + G +P H+AA G +LL A N+ ++
Sbjct: 510 AAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+LL G + + +PLH AA L +
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ GHA + + LL + A N+ +K+ + L L ++G VA++L+
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 SHGADAGAVDSTGHDALHYALHTQD----KALWRHLQQALSRRRRGGQRLVQ-----HPD 257
HG A G+ LH A H + K L +H ++ + G L Q H D
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 258 -----LASQASPSE 266
L + ASP+E
Sbjct: 749 IVTLLLKNGASPNE 762
Score = 83.2 bits (204), Expect = 1e-15
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 29/202 (14%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGST------------------------ 89
G +P ++AA + E + LL NGA+ N EDG T
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 90 -----ALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
ALH+A + + VLLQ+ N D + +PLH AA + LL + A
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +G TPL IAS G+ + LL RGA++ K++ + L A G ++E+
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL HGA A G +H A
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMA 312
Score = 82.8 bits (203), Expect = 1e-15
Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G + + LL + + + G+TALH+A ++ Q + V+ L+ +G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A + +PL+ AA V L ++ A +V DG TPL +A GH + +
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
L+ G + V AL +A A +LL + + + TG LH A H +
Sbjct: 162 HLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 231 D 231
+
Sbjct: 218 N 218
Score = 80.1 bits (196), Expect = 1e-14
Identities = 58/191 (30%), Positives = 85/191 (44%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA + A+ + Q+P H AA G T + +LL N A+ N G T LH+A
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ V LL+ A++ + + +PLH AA G LL + +A + +G T
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A + I LL RG + N + L +A ++ EVA LL +G A A
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 216 DSTGHDALHYA 226
G LH A
Sbjct: 632 SVQGVTPLHLA 642
Score = 78.2 bits (191), Expect = 4e-14
Identities = 50/152 (32%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA +G E + +LL+ A+ N N+ G T LHL VL++HG
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH A+ G V L H+A ++ G +PL A+ GH I + LL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ GA N + + L +A G V ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 17/219 (7%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTEC 69
T +AV H+ + ++ G G+V A H+AA T
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVRLPA-----------------LHIAARNDDTRT 188
Query: 70 LTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
+LL N + + ++ G T LH+A ++LL GA+ + +PLH A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSA 189
G V LL D A ++ D TPL A+ GH I LL GA + KN S
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 190 LILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ +A + + LLL + A+ + LH A H
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 70.5 bits (171), Expect = 8e-12
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G VA L S K A + +G +P HL A +G +L+ +G +++
Sbjct: 642 AAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A+ + VK LLQH A+ +A SPLH AA G V LL + A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQL 172
+ + +DG TPL IA G+ ++ L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/188 (25%), Positives = 72/188 (38%), Gaps = 33/188 (17%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+++ + F AA G + L NG DIN+ N++G LHL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHL----------------- 51
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
A+ G V+ L E L+ G T L IA+L G +
Sbjct: 52 ----------------ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
+L+ GA VN + + L +A ++ EV + LL +GA+ G L AL
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 231 DKALWRHL 238
+ + HL
Sbjct: 156 HENVVAHL 163
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 105 bits (263), Expect = 2e-22
Identities = 67/191 (35%), Positives = 94/191 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L + A NG +P H+A+ +G + +LL GA I +K +D T LH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + ++LL HGA A SP+H AA V LL ++A +D + D T
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH + LL +GA+ N N + L +AC+K V ELLL GA AV
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 216 DSTGHDALHYA 226
+G LH A
Sbjct: 401 TESGLTPLHVA 411
Score = 102 bits (254), Expect = 2e-21
Identities = 60/192 (31%), Positives = 94/192 (48%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
RVA L + A P NG +P H+A + + +LL G +S +G T LH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
Q + + LLQ+G + +A + +PLH AA G A V LL +A ++ + G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL + + GH + L++ G V+ T + + L +A G+ ++ + LL H AD A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 215 VDSTGHDALHYA 226
G+ LH A
Sbjct: 730 KTKLGYSPLHQA 741
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/199 (31%), Positives = 93/199 (46%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
++ A P + ++P H+AA G TE LL N A +N+K +D T LH A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
VK+LL++ AN + +PLH AA G +VL L + EA + G TPL +A+
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
G + LL+R A N KN + L +A + ++ +LLL G + G+
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 222 ALHYALHTQDKALWRHLQQ 240
LH A + R L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 95.1 bits (235), Expect = 3e-19
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 1/207 (0%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
H L A H G RVA + K A+P NG +P H+A K + +LL GA
Sbjct: 338 HLTPLHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
I++ E G T LH+A+ VK LLQ GA+ + + + +PLH AA +G L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 140 CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
++A ++ D +TPL A+ GH + LL+ A N+ + L +A +G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E LL A + G LH A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/174 (35%), Positives = 83/174 (47%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+AA +C+ +LL A+I+ D T LH+A + KVLL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
++ +PLH A + LL A +D + G TPL +AS GH I L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LQRGA NV++ ++ L +A G EVA+ LL + A A LH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/200 (32%), Positives = 89/200 (44%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
AVH ++ V L R + P NG +P H+AA + E LL G N+++
Sbjct: 576 AVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA + V +LL AN + + +PLH A G +L H +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D G TPL +AS G+ + LLQ A VN K S L A ++G ++ LLL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA V S G L A
Sbjct: 755 KNGASPNEVSSDGTTPLAIA 774
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 15/254 (5%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V AL +++++ + G +P H+AA G +LL A N+ ++
Sbjct: 510 AAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+LL G + + +PLH AA L +
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ GHA + + LL + A N+ +K+ + L L ++G VA++L+
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 SHGADAGAVDSTGHDALHYALHTQD----KALWRHLQQALSRRRRGGQRLVQ-----HPD 257
HG A G+ LH A H + K L +H ++ + G L Q H D
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 258 -----LASQASPSE 266
L + ASP+E
Sbjct: 749 IVTLLLKNGASPNE 762
Score = 83.2 bits (204), Expect = 1e-15
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 29/202 (14%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGST------------------------ 89
G +P ++AA + E + LL NGA+ N EDG T
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 90 -----ALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
ALH+A + + VLLQ+ N D + +PLH AA + LL + A
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +G TPL IAS G+ + LL RGA++ K++ + L A G ++E+
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL HGA A G +H A
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMA 312
Score = 82.8 bits (203), Expect = 1e-15
Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G + + LL + + + G+TALH+A ++ Q + V+ L+ +G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A + +PL+ AA V L ++ A +V DG TPL +A GH + +
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
L+ G + V AL +A A +LL + + + TG LH A H +
Sbjct: 162 HLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 231 D 231
+
Sbjct: 218 N 218
Score = 80.1 bits (196), Expect = 1e-14
Identities = 58/191 (30%), Positives = 85/191 (44%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA + A+ + Q+P H AA G T + +LL N A+ N G T LH+A
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ V LL+ A++ + + +PLH AA G LL + +A + +G T
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A + I LL RG + N + L +A ++ EVA LL +G A A
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 216 DSTGHDALHYA 226
G LH A
Sbjct: 632 SVQGVTPLHLA 642
Score = 78.2 bits (191), Expect = 4e-14
Identities = 50/152 (32%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA +G E + +LL+ A+ N N+ G T LHL VL++HG
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH A+ G V L H+A ++ G +PL A+ GH I + LL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ GA N + + L +A G V ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 17/219 (7%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTEC 69
T +AV H+ + ++ G G+V A H+AA T
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVRLPA-----------------LHIAARNDDTRT 188
Query: 70 LTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
+LL N + + ++ G T LH+A ++LL GA+ + +PLH A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSA 189
G V LL D A ++ D TPL A+ GH I LL GA + KN S
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 190 LILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ +A + + LLL + A+ + LH A H
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 70.5 bits (171), Expect = 8e-12
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G VA L S K A + +G +P HL A +G +L+ +G +++
Sbjct: 642 AAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A+ + VK LLQH A+ +A SPLH AA G V LL + A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQL 172
+ + +DG TPL IA G+ ++ L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/188 (25%), Positives = 72/188 (38%), Gaps = 33/188 (17%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+++ + F AA G + L NG DIN+ N++G LHL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHL----------------- 51
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
A+ G V+ L E L+ G T L IA+L G +
Sbjct: 52 ----------------ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
+L+ GA VN + + L +A ++ EV + LL +GA+ G L AL
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 231 DKALWRHL 238
+ + HL
Sbjct: 156 HENVVAHL 163
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 105 bits (263), Expect = 2e-22
Identities = 67/191 (35%), Positives = 94/191 (49%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA L + A NG +P H+A+ +G + +LL GA I +K +D T LH A
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ + ++LL HGA A SP+H AA V LL ++A +D + D T
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A+ GH + LL +GA+ N N + L +AC+K V ELLL GA AV
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 216 DSTGHDALHYA 226
+G LH A
Sbjct: 401 TESGLTPLHVA 411
Score = 102 bits (254), Expect = 2e-21
Identities = 60/192 (31%), Positives = 94/192 (48%)
Query: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLA 94
RVA L + A P NG +P H+A + + +LL G +S +G T LH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 95 TISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGR 154
Q + + LLQ+G + +A + +PLH AA G A V LL +A ++ + G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 155 TPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA 214
TPL + + GH + L++ G V+ T + + L +A G+ ++ + LL H AD A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 215 VDSTGHDALHYA 226
G+ LH A
Sbjct: 730 KTKLGYSPLHQA 741
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/199 (31%), Positives = 93/199 (46%)
Query: 42 RKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQ 101
++ A P + ++P H+AA G TE LL N A +N+K +D T LH A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 102 CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIAS 161
VK+LL++ AN + +PLH AA G +VL L + EA + G TPL +A+
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 162 LGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHD 221
G + LL+R A N KN + L +A + ++ +LLL G + G+
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 222 ALHYALHTQDKALWRHLQQ 240
LH A + R L Q
Sbjct: 605 PLHIAAKQNQVEVARSLLQ 623
Score = 95.1 bits (235), Expect = 3e-19
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 1/207 (0%)
Query: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
H L A H G RVA + K A+P NG +P H+A K + +LL GA
Sbjct: 338 HLTPLHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
I++ E G T LH+A+ VK LLQ GA+ + + + +PLH AA +G L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 140 CDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSA 199
++A ++ D +TPL A+ GH + LL+ A N+ + L +A +G
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 200 EVAELLLSHGADAGAVDSTGHDALHYA 226
E LL A + G LH A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 92.8 bits (229), Expect = 1e-18
Identities = 61/174 (35%), Positives = 83/174 (47%)
Query: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
NG SP H+AA +C+ +LL A+I+ D T LH+A + KVLL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 113 EDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQL 172
++ +PLH A + LL A +D + G TPL +AS GH I L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
LQRGA NV++ ++ L +A G EVA+ LL + A A LH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/200 (32%), Positives = 89/200 (44%), Gaps = 1/200 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
AVH ++ V L R + P NG +P H+AA + E LL G N+++
Sbjct: 576 AVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA + V +LL AN + + +PLH A G +L H +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D G TPL +AS G+ + LLQ A VN K S L A ++G ++ LLL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 SHGADAGAVDSTGHDALHYA 226
+GA V S G L A
Sbjct: 755 KNGASPNEVSSDGTTPLAIA 774
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 15/254 (5%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G V V AL +++++ + G +P H+AA G +LL A N+ ++
Sbjct: 510 AAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+LL G + + +PLH AA L +
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
+ G TPL +A+ GHA + + LL + A N+ +K+ + L L ++G VA++L+
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 SHGADAGAVDSTGHDALHYALHTQD----KALWRHLQQALSRRRRGGQRLVQ-----HPD 257
HG A G+ LH A H + K L +H ++ + G L Q H D
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 258 -----LASQASPSE 266
L + ASP+E
Sbjct: 749 IVTLLLKNGASPNE 762
Score = 83.2 bits (204), Expect = 1e-15
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 29/202 (14%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGST------------------------ 89
G +P ++AA + E + LL NGA+ N EDG T
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 90 -----ALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144
ALH+A + + VLLQ+ N D + +PLH AA + LL + A
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 145 FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAEL 204
++ +G TPL IAS G+ + LL RGA++ K++ + L A G ++E+
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 205 LLSHGADAGAVDSTGHDALHYA 226
LL HGA A G +H A
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMA 312
Score = 82.8 bits (203), Expect = 1e-15
Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+ NG + HLA+ +G + + LL + + + G+TALH+A ++ Q + V+ L+ +G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
AN +A + +PL+ AA V L ++ A +V DG TPL +A GH + +
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
L+ G + V AL +A A +LL + + + TG LH A H +
Sbjct: 162 HLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 231 D 231
+
Sbjct: 218 N 218
Score = 80.1 bits (196), Expect = 1e-14
Identities = 58/191 (30%), Positives = 85/191 (44%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
VA + A+ + Q+P H AA G T + +LL N A+ N G T LH+A
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ V LL+ A++ + + +PLH AA G LL + +A + +G T
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A + I LL RG + N + L +A ++ EVA LL +G A A
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 216 DSTGHDALHYA 226
G LH A
Sbjct: 632 SVQGVTPLHLA 642
Score = 78.2 bits (191), Expect = 4e-14
Identities = 50/152 (32%), Positives = 73/152 (48%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA +G E + +LL+ A+ N N+ G T LHL VL++HG
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
DA +PLH A+ G V L H+A ++ G +PL A+ GH I + LL
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELL 205
+ GA N + + L +A G V ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 17/219 (7%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTEC 69
T +AV H+ + ++ G G+V A H+AA T
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVRLPA-----------------LHIAARNDDTRT 188
Query: 70 LTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
+LL N + + ++ G T LH+A ++LL GA+ + +PLH A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSA 189
G V LL D A ++ D TPL A+ GH I LL GA + KN S
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 190 LILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
+ +A + + LLL + A+ + LH A H
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 70.5 bits (171), Expect = 8e-12
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G VA L S K A + +G +P HL A +G +L+ +G +++
Sbjct: 642 AAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM 700
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A+ + VK LLQH A+ +A SPLH AA G V LL + A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQL 172
+ + +DG TPL IA G+ ++ L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/188 (25%), Positives = 72/188 (38%), Gaps = 33/188 (17%)
Query: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
+++ + F AA G + L NG DIN+ N++G LHL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHL----------------- 51
Query: 111 ANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
A+ G V+ L E L+ G T L IA+L G +
Sbjct: 52 ----------------ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQ 230
+L+ GA VN + + L +A ++ EV + LL +GA+ G L AL
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 231 DKALWRHL 238
+ + HL
Sbjct: 156 HENVVAHL 163
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 105 bits (263), Expect = 2e-22
Identities = 80/251 (31%), Positives = 112/251 (44%), Gaps = 27/251 (10%)
Query: 10 TQVAVERWNRHDQKLLEAVHRGDVG------------RVAALASRKSARPTKLDSNGQSP 57
++ A RW+ H + L + ++ V L R+ ARP G++
Sbjct: 78 SRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTA 136
Query: 58 FHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-V 116
H A + G T C+ +LL GAD N ++DG LHL +C ++LL+ GA D
Sbjct: 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 196
Query: 117 DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLG 163
+ E +PLH AA G LL A D + +G TPL+ A +
Sbjct: 197 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTA 256
Query: 164 GHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDAL 223
+CS LL GA + D++ + L LAC +G A V ELLLS G A +D GH L
Sbjct: 257 RCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 316
Query: 224 HYALHTQDKAL 234
H AL AL
Sbjct: 317 HCALQGPAAAL 327
Score = 75.1 bits (183), Expect = 3e-13
Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103
A P D +G+ P HL G EC +LL GA ++ ++E+ T LH+A +
Sbjct: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
Query: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150
+LL+ GA DA +AE +PL A C S LL A D D
Sbjct: 217 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 276
Query: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203
D + PL +A GHAA+ LL G N D + L A + +A +A+
Sbjct: 277 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 336
Query: 204 LLLSHGA 210
LL+HGA
Sbjct: 337 ALLNHGA 343
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 104 bits (260), Expect = 4e-22
Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 21/241 (8%)
Query: 13 AVERWN-RHDQKLLEAVH----RGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
A+ W+ ++++L +H RG V L R+ ARP G++ H A + G T
Sbjct: 149 ALRLWSLTYEEELTTPLHVAASRGHT-EVLRLLLRRRARPDSAPG-GRTALHEACAAGHT 206
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-VDAENRSPLHW 126
C+ +LL GAD N ++DG LHL +C ++LL+ GA D + E +PLH
Sbjct: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
Query: 127 AASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLGGHAAICSQLL 173
AA G LL A D + +G TPL+ A + +CS LL
Sbjct: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKA 233
GA + D++ + L LAC +G A V ELLLS G A +D GH LH AL A
Sbjct: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
Query: 234 L 234
L
Sbjct: 387 L 387
Score = 75.1 bits (183), Expect = 3e-13
Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103
A P D +G+ P HL G EC +LL GA ++ ++E+ T LH+A +
Sbjct: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
Query: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150
+LL+ GA DA +AE +PL A C S LL A D D
Sbjct: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
Query: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203
D + PL +A GHAA+ LL G N D + L A + +A +A+
Sbjct: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
Query: 204 LLLSHGA 210
LL+HGA
Sbjct: 397 ALLNHGA 403
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 104 bits (260), Expect = 4e-22
Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 21/241 (8%)
Query: 13 AVERWN-RHDQKLLEAVH----RGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
A+ W+ ++++L +H RG V L R+ ARP G++ H A + G T
Sbjct: 149 ALRLWSLTYEEELTTPLHVAASRGHT-EVLRLLLRRRARPDSAPG-GRTALHEACAAGHT 206
Query: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-VDAENRSPLHW 126
C+ +LL GAD N ++DG LHL +C ++LL+ GA D + E +PLH
Sbjct: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
Query: 127 AASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLGGHAAICSQLL 173
AA G LL A D + +G TPL+ A + +CS LL
Sbjct: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
Query: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKA 233
GA + D++ + L LAC +G A V ELLLS G A +D GH LH AL A
Sbjct: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
Query: 234 L 234
L
Sbjct: 387 L 387
Score = 75.1 bits (183), Expect = 3e-13
Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103
A P D +G+ P HL G EC +LL GA ++ ++E+ T LH+A +
Sbjct: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
Query: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150
+LL+ GA DA +AE +PL A C S LL A D D
Sbjct: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
Query: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203
D + PL +A GHAA+ LL G N D + L A + +A +A+
Sbjct: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
Query: 204 LLLSHGA 210
LL+HGA
Sbjct: 397 ALLNHGA 403
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 103 bits (258), Expect = 6e-22
Identities = 59/175 (33%), Positives = 95/175 (54%)
Query: 52 SNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGA 111
++G +P +AA + +LLA+GAD N +EDG LH A + ++LL HGA
Sbjct: 393 ASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGA 452
Query: 112 NEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
DA + E +PLH AA + + LL +A ++ + +G+TPL +A+ GH ++
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKL 512
Query: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
L +GA ++ +N ++ L LA E+G + LL GA A+D +G+ LH A
Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTA 567
Score = 93.6 bits (231), Expect = 8e-19
Identities = 63/214 (29%), Positives = 102/214 (47%)
Query: 14 VERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTIL 73
V+ R L + + VA L + A P ++ G++P H+AA G + +L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Query: 74 LANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCA 133
+ GA+++++ + T LHLA + + ++ LL+ GA DA+D PLH AA+ G
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 134 SSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILA 193
+L + A L++ + G TPL +A+ GH I L + A + + + L LA
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Query: 194 CEKGSAEVAELLLSHGADAGAVDSTGHDALHYAL 227
G V LL GAD A + +G LH A+
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667
Score = 92.4 bits (228), Expect = 2e-18
Identities = 66/214 (30%), Positives = 91/214 (42%), Gaps = 1/214 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A GD G L + + + G +P HLAA +L++ AD N +
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LH+A VK+L GA DA R+PLH A G ++ L A
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
D LD G PL A+ G IC LL+ GA + + + L LA KG E+ LL
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 207 SHGADAGAVDSTGHDALHYALHTQDKALWRHLQQ 240
A+ GA+ + LH A ++A+ L Q
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647
Score = 87.8 bits (216), Expect = 5e-17
Identities = 59/193 (30%), Positives = 92/193 (47%)
Query: 36 VAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLAT 95
+ AL A ++D +G +P H AA G +LL +GA ++++ +G T LHLA
Sbjct: 410 LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469
Query: 96 ISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRT 155
+ ++L+ A+ + +AE ++PLH AA G S V LL A LD + RT
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529
Query: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
PL +A G LL+ GA + D++ L A +G + ++LL +GA
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
Query: 216 DSTGHDALHYALH 228
G LH A +
Sbjct: 590 THQGWTPLHLAAY 602
Score = 79.3 bits (194), Expect = 2e-14
Identities = 63/215 (29%), Positives = 101/215 (46%), Gaps = 1/215 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A + G V V L S+ A N ++P HLA +G + LL +GA ++ ++
Sbjct: 501 AAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G LH A + K+LL++GA+ + + +PLH AA G + LL + A +
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
Query: 147 DVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
L TPL +A+ G A+ S LLQ GA N +++ + L LA ++ + LL
Sbjct: 620 GALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679
Query: 207 SHGADAGAVDSTGHDALHYALHTQDKALWRHLQQA 241
H A+ A + G H A + A+ + L +A
Sbjct: 680 EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Score = 73.9 bits (180), Expect = 7e-13
Identities = 48/140 (34%), Positives = 73/140 (52%)
Query: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
G +P HLAA KG E + +L + A++ + T LHLA + V LLQ GA+
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 114 DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLL 173
+A + +PLH A SV+ L +H A + + G TP +A+L G+ AI L+
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
Query: 174 QRGARVNVTDKNDKSALILA 193
+ GA+++V D + L LA
Sbjct: 713 EAGAQLDVQDGVSCTPLQLA 732
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/134 (33%), Positives = 64/134 (47%), Gaps = 1/134 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A ++G + + L + A L + +P HLAA G ++ LL GAD N+ +
Sbjct: 600 AAYKGHL-EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFL 146
G T LHLA V LL+H AN A + +P H AA G + + +L + A L
Sbjct: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
Query: 147 DVLDNDGRTPLMIA 160
DV D TPL +A
Sbjct: 719 DVQDGVSCTPLQLA 732
Score = 50.4 bits (119), Expect = 8e-06
Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 1/104 (0%)
Query: 27 AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNED 86
A G+ V+AL + A P + +G +P HLA + + LL + A+++++N+
Sbjct: 633 AARHGEEAVVSALL-QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
Query: 87 GSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASS 130
G T HLA + +KVL++ GA D D + +PL A S
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 103 bits (256), Expect = 1e-21
Identities = 69/227 (30%), Positives = 109/227 (48%), Gaps = 5/227 (2%)
Query: 22 QKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADIN 81
QK+ A +GD V +R+S LD ++ HLA + G + +T+L+ I+
Sbjct: 35 QKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQID 94
Query: 82 SKNEDGSTALHLATISCQPQ-CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLC 140
+++ T L + + CQ + C +LL+HGAN + D + LH+A S S L
Sbjct: 95 VCDKENRTPL-IQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLL 153
Query: 141 DHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAE 200
H A ++ LD D TPL+ A + + LL+R A + D+ +SAL+LA S
Sbjct: 154 SHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPG 213
Query: 201 VAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRR 247
+ +LL D A D G DA YA+ L + QQ L +++
Sbjct: 214 IVNILLKQNIDVFAQDMCGRDAEDYAI---SHHLTKIQQQILEHKKK 257
Score = 45.1 bits (105), Expect = 3e-04
Identities = 50/264 (18%), Positives = 121/264 (45%), Gaps = 39/264 (14%)
Query: 750 LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809
L++EN+ L+ + +E +L+ + + + ++EL ++A + + E+ K
Sbjct: 536 LEKENKYLK-DIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLK 594
Query: 810 LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869
K+ + ++ ++R AA++ +H +++ + LK LE+ +V
Sbjct: 595 EKESKKRLEADIESYQSRLAAAISKH--------SESVKTERNLKLALERTRDVSVQV-E 645
Query: 870 LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKM------------- 916
+ A+++ + + L Q +E + + + ++ ++F KT + L++K
Sbjct: 646 MSSAISKVKDENEFLTEQLSETQIKFNALK---DKFRKTRDSLRKKSLALETVQNDLSQT 702
Query: 917 ----EHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQD--SQKNHEEIIS 970
+ + ++ EAK+ K + E + ++ ENA L QL D +++H+EI++
Sbjct: 703 QQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVT 762
Query: 971 TYRNHLLNAARGYMEHEVYNILLQ 994
N RG++E +++L+
Sbjct: 763 -------NIQRGFIESGKKDLVLE 779
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 103 bits (256), Expect = 1e-21
Identities = 69/227 (30%), Positives = 109/227 (48%), Gaps = 5/227 (2%)
Query: 22 QKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADIN 81
QK+ A +GD V +R+S LD ++ HLA + G + +T+L+ I+
Sbjct: 35 QKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQID 94
Query: 82 SKNEDGSTALHLATISCQPQ-CVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLC 140
+++ T L + + CQ + C +LL+HGAN + D + LH+A S S L
Sbjct: 95 VCDKENRTPL-IQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLL 153
Query: 141 DHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAE 200
H A ++ LD D TPL+ A + + LL+R A + D+ +SAL+LA S
Sbjct: 154 SHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPG 213
Query: 201 VAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRR 247
+ +LL D A D G DA YA+ L + QQ L +++
Sbjct: 214 IVNILLKQNIDVFAQDMCGRDAEDYAI---SHHLTKIQQQILEHKKK 257
Score = 45.1 bits (105), Expect = 3e-04
Identities = 50/264 (18%), Positives = 121/264 (45%), Gaps = 39/264 (14%)
Query: 750 LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809
L++EN+ L+ + +E +L+ + + + ++EL ++A + + E+ K
Sbjct: 536 LEKENKYLK-DIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLK 594
Query: 810 LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869
K+ + ++ ++R AA++ +H +++ + LK LE+ +V
Sbjct: 595 EKESKKRLEADIESYQSRLAAAISKH--------SESVKTERNLKLALERTRDVSVQV-E 645
Query: 870 LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKM------------- 916
+ A+++ + + L Q +E + + + ++ ++F KT + L++K
Sbjct: 646 MSSAISKVKDENEFLTEQLSETQIKFNALK---DKFRKTRDSLRKKSLALETVQNDLSQT 702
Query: 917 ----EHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQD--SQKNHEEIIS 970
+ + ++ EAK+ K + E + ++ ENA L QL D +++H+EI++
Sbjct: 703 QQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVT 762
Query: 971 TYRNHLLNAARGYMEHEVYNILLQ 994
N RG++E +++L+
Sbjct: 763 -------NIQRGFIESGKKDLVLE 779
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,790,354
Number of Sequences: 37866
Number of extensions: 1901804
Number of successful extensions: 23794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 597
Number of HSP's successfully gapped in prelim test: 1007
Number of HSP's that attempted gapping in prelim test: 11809
Number of HSP's gapped (non-prelim): 7565
length of query: 1001
length of database: 18,247,518
effective HSP length: 112
effective length of query: 889
effective length of database: 14,006,526
effective search space: 12451801614
effective search space used: 12451801614
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.