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Search of human proteins with 120432042
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
(287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 597 e-171
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 581 e-166
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 277 9e-75
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 274 7e-74
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 268 5e-72
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 96 3e-20
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 82 5e-16
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 80 2e-15
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 80 2e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 79 4e-15
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 69 5e-12
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 67 2e-11
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 67 2e-11
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 65 5e-11
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 65 7e-11
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 65 7e-11
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 64 1e-10
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 64 1e-10
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 64 1e-10
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 64 1e-10
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 64 2e-10
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 63 3e-10
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 63 3e-10
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 63 3e-10
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 62 8e-10
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 62 8e-10
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 61 1e-09
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 61 1e-09
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 61 1e-09
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 61 1e-09
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 597 bits (1539), Expect = e-171
Identities = 287/287 (100%), Positives = 287/287 (100%)
Query: 1 MPIFTFLSEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQ 60
MPIFTFLSEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQ
Sbjct: 1 MPIFTFLSEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQ 60
Query: 61 AGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERL 120
AGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERL
Sbjct: 61 AGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERL 120
Query: 121 QAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM 180
QAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM
Sbjct: 121 QAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM 180
Query: 181 ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFC 240
ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFC
Sbjct: 181 ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFC 240
Query: 241 ARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 287
ARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
Sbjct: 241 ARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 287
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 581 bits (1498), Expect = e-166
Identities = 279/279 (100%), Positives = 279/279 (100%)
Query: 9 EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL 68
EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL
Sbjct: 569 EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL 628
Query: 69 KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN 128
KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN
Sbjct: 629 KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN 688
Query: 129 RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH 188
RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH
Sbjct: 689 RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH 748
Query: 189 HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS 248
HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS
Sbjct: 749 HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS 808
Query: 249 LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 287
LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
Sbjct: 809 LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 847
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 277 bits (708), Expect = 9e-75
Identities = 135/265 (50%), Positives = 186/265 (70%), Gaps = 15/265 (5%)
Query: 32 PGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFP 91
PG PKM ++NY G P P P L Q GD +ELL+GD S +W+GR + + + G+FP
Sbjct: 577 PG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFP 633
Query: 92 SDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKE 142
S +VKPCP +P +DY+ PW+AG MER Q + L + + TYL+R R E
Sbjct: 634 SSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAE 693
Query: 143 SGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTL 202
+ +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL
Sbjct: 694 AERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTL 753
Query: 203 QFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMS 262
++PYK E SA + +R + + +P+V+G A+ARY+F ARDMRELSL +GDVV+IY+++
Sbjct: 754 KYPYKSRERSASRASSR--SPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG 811
Query: 263 AN-GWWRGEVNGRVGWFPSTYVEED 286
+ GWW+GE NGR+GWFPSTYVEE+
Sbjct: 812 GDQGWWKGETNGRIGWFPSTYVEEE 836
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 274 bits (700), Expect = 7e-74
Identities = 141/276 (51%), Positives = 184/276 (66%), Gaps = 8/276 (2%)
Query: 11 GTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKG 70
GT+K + + + + K+ + GLPKM+V + Y G PPP GP L+L GD VEL K
Sbjct: 573 GTMK--KDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKA 630
Query: 71 DAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRV 130
+A +W+GRN ++ E+G+FP + VKP P P D S WYAG MER AE+ L NR
Sbjct: 631 EAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGP-PQDLSVHLWYAGPMERAGAESILANRS 689
Query: 131 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHS 190
+ T+LVR R K++ E+AISIKYN E KHIKI+T +G + I E + F+ L ELVE+Y+ +S
Sbjct: 690 DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNS 749
Query: 191 LKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLL 250
LK+ F++LDTTLQFP+KEPE R ++ S K G A ARYDFCARD ELSL
Sbjct: 750 LKDCFKSLDTTLQFPFKEPEKRTISR-----PAVGSTKYFGTAKARYDFCARDRSELSLK 804
Query: 251 KGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEED 286
+GD++KI K GWWRGE+ GRVGWFP+ YVEED
Sbjct: 805 EGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 268 bits (684), Expect = 5e-72
Identities = 136/292 (46%), Positives = 187/292 (64%), Gaps = 40/292 (13%)
Query: 32 PGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFP 91
PG PKM ++NY G P P P L Q GD +ELL+GD S +W+GR + + + G+FP
Sbjct: 587 PG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFP 643
Query: 92 SDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKE 142
S +VKPCP +P +DY+ PW+AG MER Q + L + + TYL+R R E
Sbjct: 644 SSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAE 703
Query: 143 SGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTL 202
+ +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL
Sbjct: 704 AERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTL 763
Query: 203 QFPYKEPEHSAGQRGNRAGN---------------------------SLLSPKVLGIAIA 235
++PYK E SA + +R+ S+ +P+V+G A+A
Sbjct: 764 KYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVA 823
Query: 236 RYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEED 286
RY+F ARDMRELSL +GDVV+IY+++ + GWW+GE NGR+GWFPSTYVEE+
Sbjct: 824 RYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 96.3 bits (238), Expect = 3e-20
Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 53 EGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPW 112
E L GDT+++L + +++ G GF P + ++ P PW
Sbjct: 13 ESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYIRVKP----------HPW 60
Query: 113 YAGAMERLQAETELINRVN-STYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171
Y+G + R AE L+ R + +L+R GE+++S+ Y ++ +H K+L +
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 231
KF SL ELV++Y+ T+ Q ++ E LL
Sbjct: 121 WEEKFNSLNELVDFYR-------TTTIAKKRQIFLRDEE------------PLLKSPGAC 161
Query: 232 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284
A A++DF A+D +LS +GD++++ + + WWRG GRVG+FP +YV+
Sbjct: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213
Score = 40.0 bits (92), Expect = 0.002
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 233 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
++A Y F A + EL+ KGD +KI W++ E+ G G+ P Y+
Sbjct: 3 SVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
Score = 33.1 bits (74), Expect = 0.29
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 12/88 (13%)
Query: 12 TLKLPEKRTNGLR-RTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL-K 69
T + +KR LR P PG Q ++S P L + GD +E+L +
Sbjct: 137 TTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQL------SFRRGDIIEVLER 190
Query: 70 GDAHSLFWQGRNLASGEVGFFPSDAVKP 97
D H +W+GR+ G VGFFP V+P
Sbjct: 191 PDPH--WWRGRSC--GRVGFFPRSYVQP 214
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 82.0 bits (201), Expect = 5e-16
Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%)
Query: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158
VP P + +PWY ++ R +AE +++ R+ + +L+R R + S YAI+ + + KH
Sbjct: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692
Query: 159 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 217
+I RDG F + + F+SL+ELV YY+ HSL R L++P PE
Sbjct: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745
Query: 218 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 264
R NSL + P + ++ A YD+ A+ ELS +G ++ +K
Sbjct: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804
Query: 265 GWWRGEVNGRV-GWFPSTYVEE 285
GWW+G+ R+ +FPS YVE+
Sbjct: 805 GWWKGDYGTRIQQYFPSNYVED 826
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 80.1 bits (196), Expect = 2e-15
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
Query: 159 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 208
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
Query: 209 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 265
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
Query: 266 WWRGEVNGRVG-WFPSTYVEE 285
WWRG+ G+ WFPS YVEE
Sbjct: 828 WWRGDYGGKKQLWFPSNYVEE 848
Score = 33.5 bits (75), Expect = 0.22
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 131 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 186
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
Query: 187 KHHSLK 192
+ L+
Sbjct: 640 QQVPLR 645
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 80.1 bits (196), Expect = 2e-15
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
Query: 159 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 208
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
Query: 209 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 265
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
Query: 266 WWRGEVNGRVG-WFPSTYVEE 285
WWRG+ G+ WFPS YVEE
Sbjct: 828 WWRGDYGGKKQLWFPSNYVEE 848
Score = 33.5 bits (75), Expect = 0.22
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 131 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 186
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
Query: 187 KHHSLK 192
+ L+
Sbjct: 640 QQVPLR 645
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 79.3 bits (194), Expect = 4e-15
Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 43/232 (18%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + GD +++L + +++ +G+ GF P + ++ P PW+ G
Sbjct: 17 LSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYIEMKP----------HPWFFGK 64
Query: 117 MERLQAETELIN-RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDG----FFHIA 171
+ R +AE L R + +L+R G++++S+K+ N+ +H K+L RDG F +
Sbjct: 65 IPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVL-RDGAGKYFLWVV 123
Query: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 231
KF SL ELV+Y++ S+ + ++ ++P +
Sbjct: 124 ---KFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTY-------------------- 160
Query: 232 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
A +DF ++ EL +GD + + N WW+G +G+ G FP YV
Sbjct: 161 -VQALFDFDPQEDGELGFRRGDFIHVMDNSDPN-WWKGACHGQTGMFPRNYV 210
Score = 50.4 bits (119), Expect = 2e-06
Identities = 21/52 (40%), Positives = 33/52 (63%)
Query: 233 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284
AIA+YDF A ELS +GD++K+ + W++ E+NG+ G+ P Y+E
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 68.9 bits (167), Expect = 5e-12
Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%)
Query: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171
WY G + R +A+T L + + +LVR + G+Y +S+ N+ H I +
Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
Query: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 230
+++F L L+E+YK H L TTL P P + + G+ A N + L
Sbjct: 74 GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125
Query: 231 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 285
YDF D +L KG+++ I K W +GRVG P YVE+
Sbjct: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
Score = 52.4 bits (124), Expect = 5e-07
Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 229 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284
V AI + CA D L+L GD+VK+ T+M+ NG W GEVNGR G FP T+V+
Sbjct: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/142 (29%), Positives = 70/142 (49%), Gaps = 15/142 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + G+ ++++ + +W +L++G+ G+ PS+ V P + + WY G
Sbjct: 103 LSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI------QAEEWYFGK 155
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIKYNNEAK-----HIKILTRD-GFF 168
+ R ++E L+N N T+LVR G Y +S+ + AK H KI D G F
Sbjct: 156 ITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGF 215
Query: 169 HIAENRKFKSLMELVEYYKHHS 190
+I +F SL +LV YY H+
Sbjct: 216 YITSRTQFNSLQQLVAYYSKHA 237
Score = 32.7 bits (73), Expect = 0.38
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVN-GRVGWFPSTYV 283
+A YD+ +R +LS KG+ ++I + W ++ G+ G+ PS YV
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/142 (29%), Positives = 70/142 (49%), Gaps = 15/142 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + G+ ++++ + +W +L++G+ G+ PS+ V P + + WY G
Sbjct: 103 LSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI------QAEEWYFGK 155
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIKYNNEAK-----HIKILTRD-GFF 168
+ R ++E L+N N T+LVR G Y +S+ + AK H KI D G F
Sbjct: 156 ITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGF 215
Query: 169 HIAENRKFKSLMELVEYYKHHS 190
+I +F SL +LV YY H+
Sbjct: 216 YITSRTQFNSLQQLVAYYSKHA 237
Score = 32.7 bits (73), Expect = 0.38
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVN-GRVGWFPSTYV 283
+A YD+ +R +LS KG+ ++I + W ++ G+ G+ PS YV
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 65.5 bits (158), Expect = 5e-11
Identities = 40/142 (28%), Positives = 70/142 (49%), Gaps = 15/142 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L G+ ++L +W+ R+L +GE G+ PS+ V P + + WY G
Sbjct: 101 LSFHKGEKFQILNSSEGD-WWEARSLTTGETGYIPSNYVAPVDSI------QAEEWYFGK 153
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIK-----YNNEAKHIKILTRD-GFF 168
+ R AE +L++ N T+L+R G Y++SI+ + KH KI D G +
Sbjct: 154 LGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY 213
Query: 169 HIAENRKFKSLMELVEYYKHHS 190
+I +F++L +LV++Y +
Sbjct: 214 YITTRAQFETLQQLVQHYSERA 235
Score = 35.0 bits (79), Expect = 0.076
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
+A YD+ AR +LS KG+ +I S WW R G G+ PS YV
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNS-SEGDWWEARSLTTGETGYIPSNYV 138
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 65.1 bits (157), Expect = 7e-11
Identities = 40/138 (28%), Positives = 69/138 (50%), Gaps = 15/138 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L G+ ++L +W+ R+L +GE G+ PS+ V P + + WY G
Sbjct: 101 LSFHKGEKFQILNSSEGD-WWEARSLTTGETGYIPSNYVAPVDSI------QAEEWYFGK 153
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIK-----YNNEAKHIKILTRD-GFF 168
+ R AE +L++ N T+L+R G Y++SI+ + KH KI D G +
Sbjct: 154 LGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY 213
Query: 169 HIAENRKFKSLMELVEYY 186
+I +F++L +LV++Y
Sbjct: 214 YITTRAQFETLQQLVQHY 231
Score = 35.0 bits (79), Expect = 0.076
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
+A YD+ AR +LS KG+ +I S WW R G G+ PS YV
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNS-SEGDWWEARSLTTGETGYIPSNYV 138
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 65.1 bits (157), Expect = 7e-11
Identities = 40/138 (28%), Positives = 69/138 (50%), Gaps = 15/138 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L G+ ++L +W+ R+L +GE G+ PS+ V P + + WY G
Sbjct: 101 LSFHKGEKFQILNSSEGD-WWEARSLTTGETGYIPSNYVAPVDSI------QAEEWYFGK 153
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIK-----YNNEAKHIKILTRD-GFF 168
+ R AE +L++ N T+L+R G Y++SI+ + KH KI D G +
Sbjct: 154 LGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY 213
Query: 169 HIAENRKFKSLMELVEYY 186
+I +F++L +LV++Y
Sbjct: 214 YITTRAQFETLQQLVQHY 231
Score = 35.0 bits (79), Expect = 0.076
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
+A YD+ AR +LS KG+ +I S WW R G G+ PS YV
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNS-SEGDWWEARSLTTGETGYIPSNYV 138
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 64.3 bits (155), Expect = 1e-10
Identities = 41/142 (28%), Positives = 71/142 (50%), Gaps = 15/142 (10%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + G+ +++ + +W+ R++A+G+ G+ PS+ V P + + WY G
Sbjct: 110 LSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI------QAEEWYFGK 162
Query: 117 MERLQAETELINRVN--STYLVRHRTKESGEYAISIK-----YNNEAKHIKILTRD-GFF 168
M R AE L+N N +LVR G Y++SI+ + KH KI D G +
Sbjct: 163 MGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGY 222
Query: 169 HIAENRKFKSLMELVEYYKHHS 190
+I +F +L +LV++Y H+
Sbjct: 223 YITTRAQFDTLQKLVKHYTEHA 244
Score = 35.8 bits (81), Expect = 0.045
Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 232 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
I +A YD+ AR +LS KG+ +I + WW R G+ G+ PS YV
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGD-WWEARSIATGKNGYIPSNYV 147
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 64.3 bits (155), Expect = 1e-10
Identities = 33/130 (25%), Positives = 65/130 (50%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + GD V +L+ + +++ ++ SG+ G + A++ + S PW+ G
Sbjct: 26 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 85
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF 176
+ +A +L + +LVR + G+Y + + + + H ++L RDG I E F
Sbjct: 86 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFF 145
Query: 177 KSLMELVEYY 186
+LM++VE+Y
Sbjct: 146 CNLMDMVEHY 155
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 64.3 bits (155), Expect = 1e-10
Identities = 33/130 (25%), Positives = 65/130 (50%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + GD V +L+ + +++ ++ SG+ G + A++ + S PW+ G
Sbjct: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF 176
+ +A +L + +LVR + G+Y + + + + H ++L RDG I E F
Sbjct: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFF 187
Query: 177 KSLMELVEYY 186
+LM++VE+Y
Sbjct: 188 CNLMDMVEHY 197
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 64.3 bits (155), Expect = 1e-10
Identities = 33/130 (25%), Positives = 65/130 (50%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + GD V +L+ + +++ ++ SG+ G + A++ + S PW+ G
Sbjct: 67 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 126
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF 176
+ +A +L + +LVR + G+Y + + + + H ++L RDG I E F
Sbjct: 127 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFF 186
Query: 177 KSLMELVEYY 186
+LM++VE+Y
Sbjct: 187 CNLMDMVEHY 196
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 63.5 bits (153), Expect = 2e-10
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 5/115 (4%)
Query: 96 KPCPCV----PKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRT-KESGEYAISI 150
KP P V P WY G + R + +L + + T+LVR + K GEY +++
Sbjct: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369
Query: 151 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
+ K IK+ RDG + +E F S+++L+ +Y+H SL + LDT L +P
Sbjct: 370 RKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYP 424
Score = 56.2 bits (134), Expect = 3e-08
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRDGFFHI 170
WY G + R QAE L + + T+L+R + + G YA S+ + + KH I T GF
Sbjct: 622 WYVGKINRTQAEEMLSGKRDGTFLIRE-SSQRGCYACSVVVDGDTKHCVIYRTATGFGFA 680
Query: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEP 209
+ SL ELV +Y+H SL + L TL P + P
Sbjct: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAP 719
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 62.8 bits (151), Expect = 3e-10
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 21/172 (12%)
Query: 30 VDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSL-------FWQGRNL 82
++PG IR SG + + D + KG+ + +W+ R+L
Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
Query: 83 ASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVN--STYLVRHRT 140
+SG+ G PS+ V P + + WY G + R AE +L++ N +L+R
Sbjct: 121 SSGKTGCIPSNYVAPVDSI------QAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESE 174
Query: 141 KESGEYAISIK-----YNNEAKHIKILTRD-GFFHIAENRKFKSLMELVEYY 186
G Y++SI+ + KH KI D G ++I +F S+ ELV++Y
Sbjct: 175 TTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 32.3 bits (72), Expect = 0.49
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
IA YD+ AR +L+ KG+ I + WW R +G+ G PS YV
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGD-WWEARSLSSGKTGCIPSNYV 133
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 62.8 bits (151), Expect = 3e-10
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 21/172 (12%)
Query: 30 VDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSL-------FWQGRNL 82
++PG IR SG + + D + KG+ + +W+ R+L
Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
Query: 83 ASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVN--STYLVRHRT 140
+SG+ G PS+ V P + + WY G + R AE +L++ N +L+R
Sbjct: 121 SSGKTGCIPSNYVAPVDSI------QAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESE 174
Query: 141 KESGEYAISIK-----YNNEAKHIKILTRD-GFFHIAENRKFKSLMELVEYY 186
G Y++SI+ + KH KI D G ++I +F S+ ELV++Y
Sbjct: 175 TTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 32.3 bits (72), Expect = 0.49
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
IA YD+ AR +L+ KG+ I + WW R +G+ G PS YV
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGD-WWEARSLSSGKTGCIPSNYV 133
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 62.8 bits (151), Expect = 3e-10
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 21/172 (12%)
Query: 30 VDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSL-------FWQGRNL 82
++PG IR SG + + D + KG+ + +W+ R+L
Sbjct: 61 INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
Query: 83 ASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVN--STYLVRHRT 140
+SG+ G PS+ V P + + WY G + R AE +L++ N +L+R
Sbjct: 121 SSGKTGCIPSNYVAPVDSI------QAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESE 174
Query: 141 KESGEYAISIK-----YNNEAKHIKILTRD-GFFHIAENRKFKSLMELVEYY 186
G Y++SI+ + KH KI D G ++I +F S+ ELV++Y
Sbjct: 175 TTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 32.3 bits (72), Expect = 0.49
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYV 283
IA YD+ AR +L+ KG+ I + WW R +G+ G PS YV
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGD-WWEARSLSSGKTGCIPSNYV 133
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 61.6 bits (148), Expect = 8e-10
Identities = 44/150 (29%), Positives = 75/150 (50%), Gaps = 14/150 (9%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + G+ + +L G H+ W +G+ G+ PS+ + P + K WY G
Sbjct: 80 LSITKGEKLRVL-GYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEK------HSWYHGP 131
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILT-RDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG +++ +
Sbjct: 132 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 191
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 192 FNTLAELVHH--HSTVADG---LITTLHYP 216
Score = 37.0 bits (84), Expect = 0.020
Identities = 27/92 (29%), Positives = 38/92 (41%), Gaps = 6/92 (6%)
Query: 198 LDTTLQFPYK---EPEH-SAGQRGNRAGNSLLSPKVL--GIAIARYDFCARDMRELSLLK 251
L+ LQ P EP+ S R N N L P + +A YDF A LS+ K
Sbjct: 25 LEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITK 84
Query: 252 GDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
G+ +++ W + GW PS Y+
Sbjct: 85 GEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYI 116
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 61.6 bits (148), Expect = 8e-10
Identities = 44/150 (29%), Positives = 75/150 (50%), Gaps = 14/150 (9%)
Query: 57 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
L + G+ + +L G H+ W +G+ G+ PS+ + P + K WY G
Sbjct: 99 LSITKGEKLRVL-GYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEK------HSWYHGP 150
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILT-RDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG +++ +
Sbjct: 151 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 210
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 211 FNTLAELVHH--HSTVADG---LITTLHYP 235
Score = 36.2 bits (82), Expect = 0.034
Identities = 21/74 (28%), Positives = 30/74 (40%), Gaps = 2/74 (2%)
Query: 212 SAGQRGNRAGNSLLSPKVL--GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRG 269
S R N N L P + +A YDF A LS+ KG+ +++ W
Sbjct: 62 SEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEA 121
Query: 270 EVNGRVGWFPSTYV 283
+ GW PS Y+
Sbjct: 122 QTKNGQGWVPSNYI 135
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/150 (28%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Query: 63 DTVELLKGDAHSLFWQGRNLASGEV------GFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
+T+ + KG+ + +N EV G+ PS+ + P + K WY G
Sbjct: 109 NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEK------HSWYHGP 162
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG ++ +
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 223 FSTLAELVHH--HSTVADG---LVTTLHYP 247
Score = 32.3 bits (72), Expect = 0.49
Identities = 15/50 (30%), Positives = 22/50 (44%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
+A YDF A LS+ KG+ +++ W GW PS Y+
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/150 (28%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Query: 63 DTVELLKGDAHSLFWQGRNLASGEV------GFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
+T+ + KG+ + +N EV G+ PS+ + P + K WY G
Sbjct: 124 NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEK------HSWYHGP 177
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG ++ +
Sbjct: 178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 237
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 238 FSTLAELVHH--HSTVADG---LVTTLHYP 262
Score = 32.3 bits (72), Expect = 0.49
Identities = 15/50 (30%), Positives = 22/50 (44%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
+A YDF A LS+ KG+ +++ W GW PS Y+
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 162
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/150 (28%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Query: 63 DTVELLKGDAHSLFWQGRNLASGEV------GFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
+T+ + KG+ + +N EV G+ PS+ + P + K WY G
Sbjct: 103 NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEK------HSWYHGP 156
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG ++ +
Sbjct: 157 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 216
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 217 FSTLAELVHH--HSTVADG---LVTTLHYP 241
Score = 32.3 bits (72), Expect = 0.49
Identities = 15/50 (30%), Positives = 22/50 (44%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
+A YDF A LS+ KG+ +++ W GW PS Y+
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 141
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/150 (28%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Query: 63 DTVELLKGDAHSLFWQGRNLASGEV------GFFPSDAVKPCPCVPKPVDYSCQPWYAGA 116
+T+ + KG+ + +N EV G+ PS+ + P + K WY G
Sbjct: 109 NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEK------HSWYHGP 162
Query: 117 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHIAENRK 175
+ R AE L + +N ++LVR G+ +IS++Y H +I T DG ++ +
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222
Query: 176 FKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
F +L ELV + H ++ +G L TTL +P
Sbjct: 223 FSTLAELVHH--HSTVADG---LVTTLHYP 247
Score = 32.3 bits (72), Expect = 0.49
Identities = 15/50 (30%), Positives = 22/50 (44%)
Query: 234 IARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
+A YDF A LS+ KG+ +++ W GW PS Y+
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,091,839
Number of Sequences: 37866
Number of extensions: 589768
Number of successful extensions: 2309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 1648
Number of HSP's gapped (non-prelim): 613
length of query: 287
length of database: 18,247,518
effective HSP length: 101
effective length of query: 186
effective length of database: 14,423,052
effective search space: 2682687672
effective search space used: 2682687672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.