Search of human proteins with 24497614

Search of human proteins with 24497614

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497614 klotho [Homo sapiens]
         (1012 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497614 klotho [Homo sapiens]                                    2118   0.0  
gi|28376633 klotho beta [Homo sapiens]                                900   0.0  
gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapi...   652   0.0  
gi|110681710 lactase-like [Homo sapiens]                              374   e-103
gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]       360   4e-99
gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]      102   2e-21
gi|239754489 PREDICTED: hypothetical protein [Homo sapiens]            37   0.12 
gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo ...    37   0.12 
gi|239508715 PREDICTED: hypothetical protein [Homo sapiens]            37   0.12 
gi|213513324 hypothetical protein LOC401115 [Homo sapiens]             36   0.16 
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int...    35   0.47 
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]        35   0.47 
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]        35   0.47 
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              35   0.47 
gi|116256358 secretory carrier membrane protein 1 [Homo sapiens]       33   1.4  
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             33   1.4  
gi|222080060 Smith-Magenis syndrome chromosome region, candidate...    32   3.9  
gi|119360348 fucosidase, alpha-L-1, tissue [Homo sapiens]              32   3.9  
gi|40255245 G protein-coupled receptor 51 [Homo sapiens]               31   5.2  
gi|5032223 plexin C1 [Homo sapiens]                                    31   5.2  
gi|104876423 heparan sulfate D-glucosaminyl 3-O-sulfotransferase...    31   5.2  
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo...    31   6.7  
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ...    30   8.8  
gi|4758090 NK2 transcription factor related, locus 5 [Homo sapiens]    30   8.8  
gi|170014689 VPS10 domain receptor protein SORCS 2 [Homo sapiens]      30   8.8  
gi|17136078 VGF nerve growth factor inducible precursor [Homo sa...    30   8.8  

>gi|24497614 klotho [Homo sapiens]
          Length = 1012

 Score = 2118 bits (5489), Expect = 0.0
 Identities = 1012/1012 (100%), Positives = 1012/1012 (100%)

Query: 1    MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGT 60
            MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGT
Sbjct: 1    MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGT 60

Query: 61   FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
            FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA
Sbjct: 61   FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120

Query: 121  TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
            TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL
Sbjct: 121  TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180

Query: 181  RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
            RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP
Sbjct: 181  RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240

Query: 241  YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
            YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS
Sbjct: 241  YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300

Query: 301  HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFI 360
            HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFI
Sbjct: 301  HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFI 360

Query: 361  KGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS 420
            KGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS
Sbjct: 361  KGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS 420

Query: 421  GTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVD 480
            GTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVD
Sbjct: 421  GTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVD 480

Query: 481  FLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQ 540
            FLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQ
Sbjct: 481  FLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQ 540

Query: 541  FTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA 600
            FTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA
Sbjct: 541  FTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA 600

Query: 601  LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP 660
            LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP
Sbjct: 601  LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP 660

Query: 661  YTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRH 720
            YTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRH
Sbjct: 661  YTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRH 720

Query: 721  AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ 780
            AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ
Sbjct: 721  AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ 780

Query: 781  RNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLN 840
            RNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLN
Sbjct: 781  RNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLN 840

Query: 841  SPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK 900
            SPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK
Sbjct: 841  SPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK 900

Query: 901  AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLE 960
            AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLE
Sbjct: 901  AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLE 960

Query: 961  RFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK 1012
            RFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK
Sbjct: 961  RFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK 1012


>gi|28376633 klotho beta [Homo sapiens]
          Length = 1044

 Score =  900 bits (2326), Expect = 0.0
 Identities = 462/1014 (45%), Positives = 643/1014 (63%), Gaps = 48/1014 (4%)

Query: 17   LSLLLVLLGLGGRRLRAEPGDGAQTWARFSR-PPAPEAAGLFQGTFPDGFLWAVGSAAYQ 75
            LS L++L     R +    GDG   W++     P  E+      TFP  F W +G+ A Q
Sbjct: 41   LSALILL-----RAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQ 95

Query: 76   TEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRD 135
             EG W++ GKG SIWD F H  L      +N S   G+            SDSY  + +D
Sbjct: 96   VEGSWKKDGKGPSIWDHFIHTHL------KNVSSTNGS------------SDSYIFLEKD 137

Query: 136  TEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWD 195
              AL  +GV+ Y+FSISW R+ P+G   V N +GL+YY  LL+ L    ++P+VTLYHWD
Sbjct: 138  LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197

Query: 196  LPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAP 255
            LP  LQ+ YGGW N  + D F DYA  CF+ FG +VKYWITI NPY+VAWHGY TG  AP
Sbjct: 198  LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257

Query: 256  GIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTD-HSIK 314
            G +G+    Y V HNL+ AH+KVWH YNT FRP Q G +SI L SHWI P R  +   I 
Sbjct: 258  GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317

Query: 315  ECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPT 374
            +CQ+S+  VLGWFA P+  DGDYPE M+  L S+LP F+E+EK  ++GTADFFA  FGP 
Sbjct: 318  KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPN 377

Query: 375  LSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYL 434
             +F+ L+   K  Q  S NLR+ L+WI LE+N+P+I I ENGWF     K +D   +Y +
Sbjct: 378  -NFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMM 436

Query: 435  KKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSA 494
            K F+ + L+AI+LD + V GYTAWSL+DGFEW   Y+IRRGLFYVDF S+ K   PKSSA
Sbjct: 437  KNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSA 496

Query: 495  LFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLS--QFTDLNVYLWDVH 552
             +Y+++I +NGF        ++G FPCDF+WGV ++ ++ ++  S  QF+D ++Y+W+  
Sbjct: 497  HYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNAT 556

Query: 553  HSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVN 612
             ++ L +V+GV  K R + C DF  I+ Q+ +L  M VTH+RF+LDWA +LP GN S VN
Sbjct: 557  GNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVN 616

Query: 613  HTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARL 672
               L+YYRC+ SE +++ I+ +V L+ P   + GLP  L     W NP TA AF  YA L
Sbjct: 617  RQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGL 676

Query: 673  CFQELGHHVKLWITMNEP------YTR--NMTYSAGHNLLKAHALAWHVYNEKFRHAQNG 724
            CFQELG  VKLWIT+NEP      Y R  N TY A HNLL AHALAW +Y+ +FR +Q G
Sbjct: 677  CFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRG 736

Query: 725  KISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQR--- 781
             +S++L ADW EPA P++      AER L+F+I W AEP+F +GDYP  MR+++  +   
Sbjct: 737  AVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRR 796

Query: 782  --NNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWL 839
              ++  LP  TE E++L++GT DF AL+H+TT  V  E+    +Y+   ++Q + DIT L
Sbjct: 797  GLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRL 856

Query: 840  NSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEAL 899
            +SP+++AV+PWG+RK+L W++  YGD+ +YI ++GIDD    EDD+LR YY+  Y+ E L
Sbjct: 857  SSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQA-LEDDRLRKYYLGKYLQEVL 915

Query: 900  KAHILDGINLCGYFAYSF-NDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPET 958
            KA+++D + + GY+A+    +++ PRFG +      F+ K+S++ Y K+I S GFP   +
Sbjct: 916  KAYLIDKVRIKGYYAFKLAEEKSKPRFGFF---TSDFKAKSSIQFYNKVISSRGFPFENS 972

Query: 959  LERFC-PEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSY 1011
              R    +E T CT C F   +K L+ F+   FF++++ L  I  + ++ RR +
Sbjct: 973  SSRCSQTQENTECTVCLFLVQKKPLI-FLGCCFFSTLVLLLSIAIFQRQKRRKF 1025


>gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapiens]
          Length = 1927

 Score =  652 bits (1683), Expect = 0.0
 Identities = 375/1002 (37%), Positives = 530/1002 (52%), Gaps = 101/1002 (10%)

Query: 35   PGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFT 94
            P      W +FS  P  E    + GTF D FLW V S+AYQ EG W   GKG SIWD FT
Sbjct: 877  PSKAKVVWEKFSSQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFT 936

Query: 95   HHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWA 154
            H P +   D+               ATGD+A DSY+ +  D   LR L V  YRFSISW+
Sbjct: 937  HTPGSNVKDN---------------ATGDIACDSYHQLDADLNMLRALKVKAYRFSISWS 981

Query: 155  RVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALAD 214
            R+ P G     N  G+ YY RL+  L    + P+VTL+HWDLPQ LQD  GGW N AL D
Sbjct: 982  RIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWDLPQALQDI-GGWENPALID 1040

Query: 215  HFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLA 274
             F  YA+ CF+ FG +VK+W+T + P  +AW GY +G   PG++      Y +AH ++ A
Sbjct: 1041 LFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKA 1100

Query: 275  HAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRM-TDHSIKECQKSLDFVLGWFAKPVFI 333
            HA+V+H Y+  +R  Q G +S++LS+HW  P+       ++   + L F LGWFA P+F 
Sbjct: 1101 HARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFR 1160

Query: 334  DGDYPESMK----------NNLSSILPDFTESEKKFIKGTADFFALCF---------GPT 374
            +GDYP++MK          +  +S LP FTE EK+FI+ TAD F L            P 
Sbjct: 1161 NGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPR 1220

Query: 375  LSFQLLDPHMKFRQLESPN-------------LRQLLSWIDLEFNHPQIFIVENGWFVSG 421
            L+    +   +  + E P+              R+LL+WI  E+    I+I ENG  ++ 
Sbjct: 1221 LNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLT- 1279

Query: 422  TTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDF 481
                +D   ++Y K +I E LKA +LDG+D+ GY AWSLMD FEW  GY+++ GL++VDF
Sbjct: 1280 NPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDF 1339

Query: 482  LSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQF 541
             + ++    ++SA +Y ++I  NG P   E++ L G FP  F W       Q++    + 
Sbjct: 1340 NNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEGFIWSAASAAYQIEGAW-RA 1398

Query: 542  TDLNVYLWDV-HHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA 600
                + +WD   H+   ++ D +        C  +  I   +  LQ + V+H+RFS+ W+
Sbjct: 1399 DGKGLSIWDTFSHTPLRVENDAI----GDVACDSYHKIAEDLVTLQNLGVSHYRFSISWS 1454

Query: 601  LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP 660
             ILP G    +N   L YY  +   L+  +I P V ++     +  LP+ L   G WEN 
Sbjct: 1455 RILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIY-----HWDLPQTLQDVGGWENE 1509

Query: 661  YTALAFAEYARLCFQELGHHVKLWITMNEPYT-------------------RNMTYSAGH 701
                 F EYA + FQ LG  VK WIT+NEP+                        Y  GH
Sbjct: 1510 TIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRPGTAPYIVGH 1569

Query: 702  NLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLA 761
            NL+KAHA AWH+YN+ +R +Q G ISI + +DW EP  P +Q+D E A R ++F  GW A
Sbjct: 1570 NLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFA 1629

Query: 762  EPIFGSGDYPWVMRDWLNQR------NNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVD 815
             PIF +GDY  VM+  +  R      N   LP FTE EK+ I GT+DF   +HYTT+L  
Sbjct: 1630 HPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAY 1689

Query: 816  SEKEDPI--KYNDYLEVQEMTDITWLNSPS-QVAVVPWGLRKVLNWLKFKYGDLPMYIIS 872
            +         ++    V  + D +W +S S  + + P+G R++LNWLK +Y D P+Y+  
Sbjct: 1690 NLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTE 1749

Query: 873  NGIDDGLHAE-DDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDR------TAPRF 925
            NG+      + +D  R+YY++ YINEALKA + D ++L GY  +S  D        + RF
Sbjct: 1750 NGVSQREETDLNDTARIYYLRTYINEALKA-VQDKVDLRGYTVWSAMDNFEWATGFSERF 1808

Query: 926  GLY--RYAADQFE--PKASMKHYRKIIDSNGFPGPETLERFC 963
            GL+   Y+       PKAS K Y  ++  NGFP P T    C
Sbjct: 1809 GLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHAC 1850



 Score =  594 bits (1531), Expect = e-169
 Identities = 364/1034 (35%), Positives = 519/1034 (50%), Gaps = 152/1034 (14%)

Query: 42   WARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPP 101
            W  F+     E     Q TFP+GFLW   + A+  EGGW + G+G SIWD     P  P 
Sbjct: 363  WEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD-----PRRPL 417

Query: 102  GDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGS 161
              +               AT +VASDSY+ V  D   L  L    Y+FSISW+R+ P G 
Sbjct: 418  NTTEGQ------------ATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGH 465

Query: 162  AGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAE 221
               P+  G+ YY +L++RL++ G++P+ TL+HWDLPQ LQD +GGW N ++ D F DYA 
Sbjct: 466  GSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHWDLPQALQD-HGGWQNESVVDAFLDYAA 524

Query: 222  LCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHL 281
             CF  FG +VK W+T   P+V+++ GY TG+  PGI       + VAH +L AHA+ WH 
Sbjct: 525  FCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHH 584

Query: 282  YNTSFRPTQGGQVSIALSSHW---INPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYP 338
            YN+  RP Q G V I L+S W   ++P R  D  ++  ++ L F+LGWFA PVF+DGDYP
Sbjct: 585  YNSHHRPQQQGHVGIVLNSDWAEPLSPERPED--LRASERFLHFMLGWFAHPVFVDGDYP 642

Query: 339  ESMKNNLSSI----------LPDFTESEKKFIKGTADFFAL---------------CFGP 373
             +++  +  +          LP+FTE+EK+ +KG+ADF  L               C   
Sbjct: 643  ATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPS 702

Query: 374  TLSFQLLDPHMK--FRQLESP-------NLRQLLSWIDLEFNHPQ--IFIVENGWFVSGT 422
              +      H+   + Q  S         +R+LL ++ LE+   +  I++  NG  +  +
Sbjct: 703  YDTIGGFSQHVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGES 762

Query: 423  TKR-DDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDF 481
                DD+  + Y  ++I E LKAIK D VDV  Y A SL+DGFE   GYS R GL +V+F
Sbjct: 763  ENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNF 822

Query: 482  LSQDKMLLPKSSALFYQKLIEKNGF---------PPLPENQP------------------ 514
                K   P+ SA F+  +IEKNGF         PP   N P                  
Sbjct: 823  SDSSKSRTPRKSAYFFTSIIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKV 882

Query: 515  ----------------LEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKR 556
                              GTF  DF WGV  +  Q++            +WD   H    
Sbjct: 883  VWEKFSSQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDA-DGKGPSIWDNFTHTPGS 941

Query: 557  LIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTIL 616
             +K +          C  +  +   + +L+ + V  +RFS+ W+ I P G  S +N   +
Sbjct: 942  NVKDNAT----GDIACDSYHQLDADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGV 997

Query: 617  QYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQE 676
             YY  + + LV  NI P+V L+     +  LP+ L   G WENP     F  YA  CFQ 
Sbjct: 998  DYYNRLINGLVASNIFPMVTLF-----HWDLPQALQDIGGWENPALIDLFDSYADFCFQT 1052

Query: 677  LGHHVKLWITMNEP-YTRNMTYSAG-----------------HNLLKAHALAWHVYNEKF 718
             G  VK W+T NEP Y   + Y +G                 H ++KAHA  +H Y+EK+
Sbjct: 1053 FGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKY 1112

Query: 719  RHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWL 778
            R  Q G IS++L   W EP  P   +D E A+R+L+F +GW A PIF +GDYP  M+  +
Sbjct: 1113 RQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKV 1172

Query: 779  NQRNNF------LLPYFTEDEKKLIQGTFDFLALSHYTTILVD--SEKEDPIKYNDYLEV 830
              R+         LP FTE+EK+ I+ T D   L+ Y + +V   + + +P  Y D  E+
Sbjct: 1173 GNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEM 1232

Query: 831  QEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYY 890
             E  D +W  S +     PWG R++LNW+K +YGD+P+YI  NG+       +D  R++Y
Sbjct: 1233 AEEEDPSW-PSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFY 1291

Query: 891  MQNYINEALKAHILDGINLCGYFAYSFNDR------TAPRFGLYRYAADQFE----PKAS 940
             + YINEALKA+ LDGI+L GY A+S  D          +FGLY    +        +AS
Sbjct: 1292 HKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARAS 1351

Query: 941  MKHYRKIIDSNGFP 954
             ++Y ++I +NG P
Sbjct: 1352 ARYYTEVITNNGMP 1365



 Score =  287 bits (734), Expect = 4e-77
 Identities = 238/856 (27%), Positives = 357/856 (41%), Gaps = 138/856 (16%)

Query: 144 VTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDA 203
           +THY+  +SWA++LP GS   P+ + ++ YRRLL+ L+   +QP+V L+H  LP      
Sbjct: 84  ITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPASTLRR 143

Query: 204 YGGWANRALADHFRDYAELCFRHFGGQVKYWITI-DNPYVVAWHGYATGRLAPGIRGSPR 262
                  A AD F DYA   F  FG  V  W T  D   V+    +   R +        
Sbjct: 144 -----TEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRASQ------- 191

Query: 263 LGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDF 322
                   L  AH K + +Y+ S+   QGG++S+ L +                      
Sbjct: 192 -----LQTLSDAHRKAYEIYHESYA-FQGGKLSVVLRAE--------------------- 224

Query: 323 VLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDP 382
                        D PE +     S L           + T DF +L             
Sbjct: 225 -------------DIPELLLEPPISALA----------QDTVDFLSL------------- 248

Query: 383 HMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442
            + +      +LRQ LS +       ++FI         +T ++ A  ++ L        
Sbjct: 249 DLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL-------F 301

Query: 443 KAIKLDGVDVIGYTA---WSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQK 499
           +AI  D V  IG+      S     +     S+   L       QD      S A  YQ+
Sbjct: 302 EAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQR 361

Query: 500 LIEKNGFPPLPENQP-LEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLI 558
           + E        E    L+ TFP  F WG       V+   ++     V +WD        
Sbjct: 362 IWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAE-GGRGVSIWDPRRPLNTT 420

Query: 559 KVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQY 618
           +    +     SY      +   +ALL  +    ++FS+ W+ I P+G+ S  +   + Y
Sbjct: 421 EGQATLEVASDSY----HKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAY 476

Query: 619 YRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELG 678
           Y  +   L    I P+  L+     +  LP+ L   G W+N     AF +YA  CF   G
Sbjct: 477 YNKLIDRLQDAGIEPMATLF-----HWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFG 531

Query: 679 HHVKLWITMNEPYTRNM------------------TYSAGHNLLKAHALAWHVYNEKFRH 720
             VKLW+T +EP+  +                   ++   H +LKAHA  WH YN   R 
Sbjct: 532 DRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRP 591

Query: 721 AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ 780
            Q G + I L +DW EP  P   +D   +ER L F +GW A P+F  GDYP  +R  + Q
Sbjct: 592 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQ 651

Query: 781 RNN------FLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPI--KYNDYLEVQE 832
            N         LP FTE EK+L++G+ DFL LSHYT+ L+ +  ++     Y+      +
Sbjct: 652 MNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ 711

Query: 833 MTDITW-LNSPSQVAVVPWGLRKVLNWLKFKY--GDLPMYIISNG--IDDGLHAEDDQLR 887
             +  W   S S + VVPWG+R++L ++  +Y  G +P+Y+  NG  I +  +  DD LR
Sbjct: 712 HVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLR 771

Query: 888 VYYMQNYINEALKAHILDGINLCGYFAYSFND------RTAPRFGLYRY----AADQFEP 937
           V Y   YINE LKA   D +++  Y A S  D        + RFGL+      ++    P
Sbjct: 772 VDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTP 831

Query: 938 KASMKHYRKIIDSNGF 953
           + S   +  II+ NGF
Sbjct: 832 RKSAYFFTSIIEKNGF 847



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 19/157 (12%)

Query: 585 LQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPN 644
           L    +TH++  L WA +LP G+    +   +Q YR +   L    + P+V L     P 
Sbjct: 79  LHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPA 138

Query: 645 QGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNE--------PYTRNMT 696
             L R  A          A  FA+YA   F   G  V +W T ++        P+  +  
Sbjct: 139 STLRRTEA---------FADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRA 189

Query: 697 YSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQAD 733
            S    L  AH  A+ +Y+E +   Q GK+S+ L+A+
Sbjct: 190 -SQLQTLSDAHRKAYEIYHESYAF-QGGKLSVVLRAE 224


>gi|110681710 lactase-like [Homo sapiens]
          Length = 567

 Score =  374 bits (960), Expect = e-103
 Identities = 210/500 (42%), Positives = 286/500 (57%), Gaps = 55/500 (11%)

Query: 46  SRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSR 105
           +R  +PE A  + GTFP GF W VGS+AYQTEG W Q GKG SIWD FTH          
Sbjct: 22  ARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHS--------- 72

Query: 106 NASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNG-SAGV 164
                 G    L   T DVA D Y  V  D   LREL V HYRFS+SW R+LP G  A  
Sbjct: 73  ------GKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQ 126

Query: 165 PNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCF 224
            N++G+ +Y  L++ L    + P+VTL+HWDLPQ LQ  YGGW N ++A++FRDYA LCF
Sbjct: 127 VNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCF 186

Query: 225 RHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNT 284
             FG +VK+WIT  +P  +A  GY TG  APG++      Y  AH+++ AHAK WH YNT
Sbjct: 187 EAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNT 246

Query: 285 SFRPTQGGQVSIALSSHWINPRRMTD-HSIKECQKSLDFVLGWFAKPVFIDGDYPESMKN 343
           ++R  Q G V I+L+  W  P  +++   ++  ++ L F LGWFA P++  GDYP+ MK+
Sbjct: 247 TWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKD 305

Query: 344 NLS----------SILPDFTESEKKFIKGTADFFALCF---------------GPTLS-- 376
            +           S LP F+  EK +IKGT+DF  L                 GP+    
Sbjct: 306 YIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQND 365

Query: 377 ---FQLLDPH-----MKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS-GTTKRDD 427
               +L+DP+      K+        R+LL++   ++  P I+++ENG       T+  D
Sbjct: 366 RDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCD 425

Query: 428 AKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKM 487
              + YLK +I E LKAIK DG ++ GYT+WSL+D FEW +GYS R G +YV+F  ++K 
Sbjct: 426 EWRIQYLKGYINEMLKAIK-DGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKP 484

Query: 488 LLPKSSALFYQKLIEKNGFP 507
             PK+S  +Y+K+I  NGFP
Sbjct: 485 RYPKASVQYYKKIIIANGFP 504



 Score =  288 bits (736), Expect = 2e-77
 Identities = 180/498 (36%), Positives = 265/498 (53%), Gaps = 54/498 (10%)

Query: 517 GTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFA 576
           GTFP  F+WGV  +  Q +    Q       +WDV       KV G  T      C  + 
Sbjct: 35  GTFPLGFSWGVGSSAYQTEGAWDQ-DGKGPSIWDVFTHSGKGKVLGNETADVA--CDGYY 91

Query: 577 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQS-QVNHTILQYYRCMASELVRVNITPVV 635
            +Q  I LL+E+HV H+RFSL W  +LP G ++ QVN   +++Y  +   L+  NITP+V
Sbjct: 92  KVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIV 151

Query: 636 ALWQPMAPNQGLPRLL-ARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTR- 693
            L      +  LP+LL  + G W+N   A  F +YA LCF+  G  VK WIT ++P    
Sbjct: 152 TLH-----HWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMA 206

Query: 694 -----------------NMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIE 736
                               Y A H+++KAHA AWH YN  +R  Q G + I+L  DW E
Sbjct: 207 EKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGE 266

Query: 737 PACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRN------NFLLPYFT 790
           P    + KD E AER L+F +GW A PI+ +GDYP VM+D++ +++         LP F+
Sbjct: 267 PVDISNPKDLEAAERYLQFCLGWFANPIY-AGDYPQVMKDYIGRKSAEQGLEMSRLPVFS 325

Query: 791 EDEKKLIQGTFDFLALSHYTTILVDSEKEDPIK----YNDYLEVQEMTDITWLNSPSQ-V 845
             EK  I+GT DFL L H+TT  + +E+  P +    Y +  ++ E+ D  W +  S+ +
Sbjct: 326 LQEKSYIKGTSDFLGLGHFTTRYI-TERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWL 384

Query: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAED--DQLRVYYMQNYINEALKAHI 903
             VPWG R++LN+ + +YGD P+Y++ NG     H     D+ R+ Y++ YINE LKA I
Sbjct: 385 YSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKA-I 443

Query: 904 LDGINLCGYFAYSFNDR------TAPRFGLYRYAADQFE----PKASMKHYRKIIDSNGF 953
            DG N+ GY ++S  D+       + R+G Y    +       PKAS+++Y+KII +NGF
Sbjct: 444 KDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGF 503

Query: 954 PGPETLERFCPEEFTVCT 971
           P P  +E +  +    C+
Sbjct: 504 PNPREVESWYLKALETCS 521


>gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]
          Length = 469

 Score =  360 bits (924), Expect = 4e-99
 Identities = 200/480 (41%), Positives = 278/480 (57%), Gaps = 53/480 (11%)

Query: 61  FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
           FP GF WA  +AAYQ EGGW   GKG  +WDTFTH                G     +  
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQ---------------GGERVFKNQ 47

Query: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
           TGDVA  SY     D + +++LG+THYRFS+SW+R+LP+G+ G  N++G+ YY ++++ L
Sbjct: 48  TGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDL 107

Query: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
            + GV P+VTLYH+DLPQ L+D  GGW + A+ + F  YA+ CF  FG +VK WITI+  
Sbjct: 108 LKNGVTPIVTLYHFDLPQTLED-QGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEA 166

Query: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
            V++   Y  G   PGI      GY  AHNL+ AHA+ WH Y++ FR  Q G VS++L +
Sbjct: 167 NVLSVMSYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFA 226

Query: 301 HWINPRRMTDHSIKECQK-SLDFVLGWFAKPVFIDGDYPESMKNNLSSI----------L 349
            W+ P      S +E  K ++ F L  FAKP+FIDGDYPE +K+ ++S+          L
Sbjct: 227 VWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRL 286

Query: 350 PDFTESEKKFIKGTADFFALCFGPT--LSFQ---------LLDPHMKFRQLESPNLR--- 395
           P+FTE EKK IKGTADFFA+ +  T  + +Q         L D  ++F     P+ +   
Sbjct: 287 PEFTEEEKKMIKGTADFFAVQYYTTRLIKYQENKKGELGILQDAEIEF--FPDPSWKNVD 344

Query: 396 ----------QLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAI 445
                     +LL +I   +N+P I+I ENG+  S     DD +   Y ++   E  KAI
Sbjct: 345 WIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAI 404

Query: 446 KLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNG 505
           +LD V++  Y AWSL+D FEW++GYS R GLF+VDF    +  +P +SA  Y K+I  NG
Sbjct: 405 QLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNG 464



 Score =  233 bits (594), Expect = 7e-61
 Identities = 145/418 (34%), Positives = 216/418 (51%), Gaps = 43/418 (10%)

Query: 572 CVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNI 631
           C  +   +  +  ++++ +TH+RFSL W+ +LP G    +N   + YY  +  +L++  +
Sbjct: 53  CGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGV 112

Query: 632 TPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNE-- 689
           TP+V L+     +  LP+ L  QG W +     +F +YA+ CF   G  VK WIT+NE  
Sbjct: 113 TPIVTLY-----HFDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEAN 167

Query: 690 ----------------PYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQAD 733
                           P+     Y A HNL+KAHA +WH Y+  FR  Q G +S++L A 
Sbjct: 168 VLSVMSYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAV 227

Query: 734 WIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDW---LNQRNNF---LLP 787
           W+EPA P S  D+E A+R + F +   A+PIF  GDYP V++     ++Q+  +    LP
Sbjct: 228 WLEPADPNSVSDQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLP 287

Query: 788 YFTEDEKKLIQGTFDFLALSHYTTILV--DSEKEDPIKYNDYLEVQEMTDITWLNSPSQV 845
            FTE+EKK+I+GT DF A+ +YTT L+     K+  +      E++   D +W N    +
Sbjct: 288 EFTEEEKKMIKGTADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKN-VDWI 346

Query: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAE-DDQLRVYYMQNYINEALKAHIL 904
            VVPWG+ K+L ++K  Y +  +YI  NG      A  DD  R  Y +    E  KA  L
Sbjct: 347 YVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQL 406

Query: 905 DGINLCGYFAYS------FNDRTAPRFGLYRY----AADQFEPKASMKHYRKIIDSNG 952
           D +NL  Y A+S      +N   + RFGL+       A    P  S K Y KII +NG
Sbjct: 407 DKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNG 464


>gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]
          Length = 162

 Score =  102 bits (253), Expect = 2e-21
 Identities = 48/111 (43%), Positives = 65/111 (58%), Gaps = 15/111 (13%)

Query: 61  FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
           FP GF WA  +AAYQ EGGW   GKG  +WDTFTH                G     +  
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQ---------------GGERVFKNQ 47

Query: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLR 171
           TGDVA  SY     D + +++LG+THYRFS+SW+R+LP+G+ G  N++ ++
Sbjct: 48  TGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAIQ 98



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 33/63 (52%), Positives = 44/63 (69%)

Query: 443 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIE 502
           KAI+LD V++  Y AWSL+D FEW++GYS R GLF+VDF    +  +P +SA  Y K+I 
Sbjct: 95  KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIR 154

Query: 503 KNG 505
            NG
Sbjct: 155 NNG 157



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 13/46 (28%), Positives = 26/46 (56%)

Query: 572 CVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQ 617
           C  +   +  +  ++++ +TH+RFSL W+ +LP G    +N   +Q
Sbjct: 53  CGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAIQ 98



 Score = 30.4 bits (67), Expect = 8.8
 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 12/69 (17%)

Query: 894 YINEALKAHILDGINLCGYFAYS------FNDRTAPRFGLYRY----AADQFEPKASMKH 943
           +IN+  KA  LD +NL  Y A+S      +N   + RFGL+       A    P  S K 
Sbjct: 91  FINQ--KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKE 148

Query: 944 YRKIIDSNG 952
           Y KII +NG
Sbjct: 149 YAKIIRNNG 157


>gi|239754489 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 228

 Score = 36.6 bits (83), Expect = 0.12
 Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 2/57 (3%)

Query: 1   MPASAPPRRPRPP-PPSLS-LLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAG 55
           +PA   PR  RPP PPS++ +     GLG R +   P    ++WAR +  P   AAG
Sbjct: 158 LPAHRAPRLARPPVPPSVAHVARASAGLGARPVPGGPAGPRESWARRTSSPPRGAAG 214


>gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo
           sapiens]
          Length = 231

 Score = 36.6 bits (83), Expect = 0.12
 Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 2/57 (3%)

Query: 1   MPASAPPRRPRPP-PPSLS-LLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAG 55
           +PA   PR  RPP PPS++ +     GLG R +   P    ++WAR +  P   AAG
Sbjct: 161 LPAHRAPRLARPPVPPSVAHVARASAGLGARPVPGGPAGPRESWARRTSSPPRGAAG 217


>gi|239508715 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 231

 Score = 36.6 bits (83), Expect = 0.12
 Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 2/57 (3%)

Query: 1   MPASAPPRRPRPP-PPSLS-LLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAG 55
           +PA   PR  RPP PPS++ +     GLG R +   P    ++WAR +  P   AAG
Sbjct: 161 LPAHRAPRLARPPVPPSVAHVARASAGLGARPVPGGPAGPRESWARRTSSPPRGAAG 217


>gi|213513324 hypothetical protein LOC401115 [Homo sapiens]
          Length = 139

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 22/41 (53%), Positives = 23/41 (56%), Gaps = 4/41 (9%)

Query: 3  ASAPPRRPR----PPPPSLSLLLVLLGLGGRRLRAEPGDGA 39
          A APP   R    PPPP L LLL+ L L G R RAEP   A
Sbjct: 44 AMAPPPACRSPMSPPPPPLLLLLLSLALLGARARAEPAGSA 84


>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
           interacting protein [Homo sapiens]
          Length = 1211

 Score = 34.7 bits (78), Expect = 0.47
 Identities = 19/30 (63%), Positives = 20/30 (66%), Gaps = 2/30 (6%)

Query: 3   ASAPPRRPRPPPPSLSLLLV--LLGLGGRR 30
           ASAPPRRP  PPP  + LLV  L G GG R
Sbjct: 248 ASAPPRRPDEPPPRRASLLVGGLAGPGGAR 277


>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
          Length = 1712

 Score = 34.7 bits (78), Expect = 0.47
 Identities = 22/53 (41%), Positives = 27/53 (50%), Gaps = 3/53 (5%)

Query: 3  ASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAG 55
          AS    RP PPP    LLL+LL L  R    E G G   WAR++R     ++G
Sbjct: 2  ASGSRWRPTPPP---LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSG 51


>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
          Length = 1642

 Score = 34.7 bits (78), Expect = 0.47
 Identities = 22/53 (41%), Positives = 27/53 (50%), Gaps = 3/53 (5%)

Query: 3  ASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAG 55
          AS    RP PPP    LLL+LL L  R    E G G   WAR++R     ++G
Sbjct: 2  ASGSRWRPTPPP---LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSG 51


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 34.7 bits (78), Expect = 0.47
 Identities = 35/127 (27%), Positives = 44/127 (34%), Gaps = 6/127 (4%)

Query: 2   PASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTF 61
           P S PP    PPPP+    +V+          EP      W     PPAPE   L    F
Sbjct: 730 PPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQD-PNWPP-PPPPAPEEQDLSMADF 787

Query: 62  P---DGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQ 118
           P   + F            G  +     A+   + T   + PPG       P  AP+P  
Sbjct: 788 PPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAP-PAPAPAS 846

Query: 119 PATGDVA 125
            A G VA
Sbjct: 847 SAPGHVA 853


>gi|116256358 secretory carrier membrane protein 1 [Homo sapiens]
          Length = 338

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 21/74 (28%), Positives = 31/74 (41%), Gaps = 11/74 (14%)

Query: 503 KNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDG 562
           KN +PPLP N P+   F  DF+       + +     +   L  YLW  H     + + G
Sbjct: 117 KNNWPPLPSNFPVGPCFYQDFS-------VDIPVEFQKTVKLMYYLWMFHAVTLFLNIFG 169

Query: 563 VVTKKRKSYCVDFA 576
            +      +CVD A
Sbjct: 170 CLA----WFCVDSA 179


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 33/119 (27%), Positives = 48/119 (40%), Gaps = 16/119 (13%)

Query: 2    PASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTF 61
            PA  P   P P PP+ +           +      +  QT ++ S+ P P +  L     
Sbjct: 1914 PAPTPVSAPNPAPPAPAQTQA-------QTHKPVQNPLQTTSQSSKQP-PPSIRLPSAQT 1965

Query: 62   PDGFLWAVGSAAYQTEGGWQQHGK-GASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQP 119
            P+G  +     + QT    Q HG   A +WD    + +APP    + S  LG  SP QP
Sbjct: 1966 PNGTDYVASGKSIQTP---QSHGTLTAELWD----NKVAPPAVLNDISKKLGPISPPQP 2017


>gi|222080060 Smith-Magenis syndrome chromosome region, candidate 7
           isoform 3 [Homo sapiens]
          Length = 205

 Score = 31.6 bits (70), Expect = 3.9
 Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 13/89 (14%)

Query: 4   SAPPRRPRPPPPSLSLLLVLLGLGGRR------LRAEPGDGAQTWARFSRPPA----PEA 53
           + P  +PRPPP +LS  ++ L            LRA P D   +   F +       P A
Sbjct: 76  ATPHLQPRPPPAALSQPVLPLAPSSSAPGEAAGLRAGPCDHPSSPGGFGQTAGWRHRPGA 135

Query: 54  AGLFQGTFPDGFLWAV---GSAAYQTEGG 79
           AGL     P   LW +   G+A  +  GG
Sbjct: 136 AGLLSEQVPGTALWGIRAWGAALRRAAGG 164


>gi|119360348 fucosidase, alpha-L-1, tissue [Homo sapiens]
          Length = 466

 Score = 31.6 bits (70), Expect = 3.9
 Identities = 33/103 (32%), Positives = 41/103 (39%), Gaps = 6/103 (5%)

Query: 5   APPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDG-AQTWARFSRPPAPEAAGLFQGTFPD 63
           AP  R RP  P+L LLL+ LG      RA+P       W      P P  A   +  F  
Sbjct: 3   APGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLP--AWFDEAKFGV 60

Query: 64  GFLWAVGSA-AYQTEG-GWQQHGKGASIWDTFTHHPLAPPGDS 104
              W V S  A+ +E   W   G+G   +  F      PPG S
Sbjct: 61  FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNY-PPGFS 102


>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 31.2 bits (69), Expect = 5.2
 Identities = 22/50 (44%), Positives = 26/50 (52%), Gaps = 5/50 (10%)

Query: 7  PRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGL 56
          P  P PPPP+  LLL+LL L    L   P  GA  WAR +  P P +  L
Sbjct: 12 PPPPPPPPPARLLLLLLLPL---LLPLAP--GAWGWARGAPRPPPSSPPL 56


>gi|5032223 plexin C1 [Homo sapiens]
          Length = 1568

 Score = 31.2 bits (69), Expect = 5.2
 Identities = 28/75 (37%), Positives = 32/75 (42%), Gaps = 15/75 (20%)

Query: 5  APPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQ--TWARFSRPPAPEAAGLFQGTFP 62
          APPR PRP  P L LL  LL L      A PG GA    W       + +A G    +  
Sbjct: 8  APPRPPRPAAP-LPLLAYLLAL------AAPGRGADEPVWR------SEQAIGAIAASQE 54

Query: 63 DGFLWAVGSAAYQTE 77
          DG   A GS   Q +
Sbjct: 55 DGVFVASGSCLDQLD 69


>gi|104876423 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4
           [Homo sapiens]
          Length = 456

 Score = 31.2 bits (69), Expect = 5.2
 Identities = 28/99 (28%), Positives = 31/99 (31%), Gaps = 21/99 (21%)

Query: 2   PASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTF 61
           P +A    P PPPPSL    V LG   +     P D A        PP P       GT 
Sbjct: 69  PGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNAS----HGEPPEPPEQPAAPGT- 123

Query: 62  PDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAP 100
                            GW     G    D +   PLAP
Sbjct: 124 ----------------DGWGLPSGGGGAQDAWLRTPLAP 146


>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
           motif, 5 preproprotein [Homo sapiens]
          Length = 930

 Score = 30.8 bits (68), Expect = 6.7
 Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 1/62 (1%)

Query: 424 KRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLS 483
           K+ + +Y+   K  I  +   I ++G  V+ Y+ WS  D F    GYS  + +  V  L+
Sbjct: 778 KKKNGEYLINGKYMISTSETIIDINGT-VMNYSGWSHRDDFLHGMGYSATKEILIVQILA 836

Query: 484 QD 485
            D
Sbjct: 837 TD 838


>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
          [Homo sapiens]
          Length = 328

 Score = 30.4 bits (67), Expect = 8.8
 Identities = 21/52 (40%), Positives = 24/52 (46%), Gaps = 9/52 (17%)

Query: 1  MPASAPPRRPRPPPP---SLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPP 49
          +P    P  P PPPP    L LLL+LLG  G       G GA+    F  PP
Sbjct: 2  LPRVGCPALPLPPPPLLPLLPLLLLLLGASG------GGGGARAEVLFRCPP 47


>gi|4758090 NK2 transcription factor related, locus 5 [Homo sapiens]
          Length = 324

 Score = 30.4 bits (67), Expect = 8.8
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 14/71 (19%)

Query: 101 PGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNG 160
           PG S  A+ P G PSP QPAT    ++  N    D  A++  G+             P  
Sbjct: 266 PGYSCTAAYPAG-PSPAQPATAAANNNFVNFGVGDLNAVQSPGI-------------PQS 311

Query: 161 SAGVPNREGLR 171
           ++GV    G+R
Sbjct: 312 NSGVSTLHGIR 322


>gi|170014689 VPS10 domain receptor protein SORCS 2 [Homo sapiens]
          Length = 1159

 Score = 30.4 bits (67), Expect = 8.8
 Identities = 28/73 (38%), Positives = 30/73 (41%), Gaps = 26/73 (35%)

Query: 3  ASAPPRRPRPPPPSLSLLLVLLGLGGR--------RL----------------RAEPGDG 38
          A  PPR PR  P  L LLL+LLG  G         RL                RAEPG G
Sbjct: 24 APPPPRSPRSRP--LLLLLLLLGACGAAGRSPEPGRLGPHAQLTRVPRSPPAGRAEPGGG 81

Query: 39 AQTWARFSRPPAP 51
              AR + P AP
Sbjct: 82 EDRQARGTEPGAP 94


>gi|17136078 VGF nerve growth factor inducible precursor [Homo
           sapiens]
          Length = 615

 Score = 30.4 bits (67), Expect = 8.8
 Identities = 44/154 (28%), Positives = 56/154 (36%), Gaps = 24/154 (15%)

Query: 4   SAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPG--DGAQTWARFSRPPAPEAAG-LFQGT 60
           +APP RP   PP LS        G     A PG  DG+    R +R   P+  G LFQG 
Sbjct: 22  AAPPGRPEAQPPPLSSEHKEPVAGD----AVPGPKDGSAPEVRGARNSEPQDEGELFQGV 77

Query: 61  FPDGFLW---------AVGSAAYQTEGGWQQHGKGASIWDTF---THHPLAPPGDSRNAS 108
            P              A   A   ++ G ++    A + +T    TH   AP        
Sbjct: 78  DPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPE---- 133

Query: 109 LPLGAPSPLQPATGDVASDSYNNVFRDTEALREL 142
            P   P P  P  G  ASD    +      L+EL
Sbjct: 134 -PAAPPRPQTPENGPEASDPSEELEALASLLQEL 166


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.451 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,760,354
Number of Sequences: 37866
Number of extensions: 2116117
Number of successful extensions: 7305
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 7132
Number of HSP's gapped (non-prelim): 61
length of query: 1012
length of database: 18,247,518
effective HSP length: 112
effective length of query: 900
effective length of database: 14,006,526
effective search space: 12605873400
effective search space used: 12605873400
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.