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Search of human proteins with 24308334
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308334 family with sequence similarity 120B [Homo sapiens]
(910 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308334 family with sequence similarity 120B [Homo sapiens] 1886 0.0
gi|39652628 oxidative stress-associated Src activator [Homo sapi... 130 7e-30
gi|157388908 hypothetical protein LOC54954 [Homo sapiens] 115 1e-25
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 57 8e-08
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 50 1e-05
gi|110349719 titin isoform N2-A [Homo sapiens] 48 5e-05
gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo... 47 6e-05
gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo ... 47 6e-05
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 47 1e-04
gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo ... 45 3e-04
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 44 7e-04
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 44 7e-04
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 44 9e-04
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 42 0.002
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 42 0.002
gi|169171269 PREDICTED: similar to forkhead box L2 [Homo sapiens] 42 0.003
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 40 0.008
gi|39995071 exonuclease 1 isoform b [Homo sapiens] 40 0.010
gi|39995069 exonuclease 1 isoform a [Homo sapiens] 40 0.010
gi|18491016 exonuclease 1 isoform b [Homo sapiens] 40 0.010
gi|7657577 SHP2-interacting transmembrane adaptor protein [Homo ... 40 0.010
gi|150378528 G protein-coupled receptor associated sorting prote... 39 0.022
gi|150378489 G protein-coupled receptor associated sorting prote... 39 0.022
gi|103472136 G protein-coupled receptor associated sorting prote... 39 0.022
gi|51702248 G protein-coupled receptor associated sorting protei... 39 0.029
gi|19923967 G protein-coupled receptor associated sorting protei... 39 0.029
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 39 0.029
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 39 0.029
gi|118918411 zinc finger protein 777 [Homo sapiens] 39 0.029
gi|91982772 mucin 17 [Homo sapiens] 38 0.038
>gi|24308334 family with sequence similarity 120B [Homo sapiens]
Length = 910
Score = 1886 bits (4886), Expect = 0.0
Identities = 910/910 (100%), Positives = 910/910 (100%)
Query: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC 60
MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
Sbjct: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC 60
Query: 61 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK 120
GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
Sbjct: 61 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK 120
Query: 121 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT 180
SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
Sbjct: 121 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT 180
Query: 181 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE 240
DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
Sbjct: 181 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE 240
Query: 241 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG 300
SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
Sbjct: 241 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG 300
Query: 301 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE 360
MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
Sbjct: 301 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE 360
Query: 361 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE 420
SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
Sbjct: 361 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE 420
Query: 421 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE 480
ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
Sbjct: 421 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE 480
Query: 481 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF 540
SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
Sbjct: 481 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF 540
Query: 541 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE 600
KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
Sbjct: 541 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE 600
Query: 601 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH 660
IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
Sbjct: 601 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH 660
Query: 661 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL 720
PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
Sbjct: 661 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL 720
Query: 721 CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL 780
CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL
Sbjct: 721 CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL 780
Query: 781 TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL 840
TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL
Sbjct: 781 TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL 840
Query: 841 KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR 900
KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR
Sbjct: 841 KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR 900
Query: 901 QYEHDQWRRY 910
QYEHDQWRRY
Sbjct: 901 QYEHDQWRRY 910
>gi|39652628 oxidative stress-associated Src activator [Homo
sapiens]
Length = 1118
Score = 130 bits (326), Expect = 7e-30
Identities = 85/265 (32%), Positives = 131/265 (49%), Gaps = 22/265 (8%)
Query: 575 EILKVARTHHVQAESY-LVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLL 633
E+L+VA H + Y ++++++ GEI+ + ++EDE ++ LP A +YRP+RQ VY +L
Sbjct: 554 EVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVL 613
Query: 634 LEDCQDVTST---------------CLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSL 678
+ T + +KEW Y G + P+LV L P+L
Sbjct: 614 FSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFR-EWTCPNL 672
Query: 679 KILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESP--FQALCCLLIYLFVQVDTLCL 736
K LWL + E + RR+ LAC S + L P LCC+L Y+ L
Sbjct: 673 KRLWLGKAVEDKNRRMRAFLACMR-SDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARIL 731
Query: 737 --EDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPW 794
++L AF+AQAL + QL L+ + ++PR +QL +L + G+ + N ACG P
Sbjct: 732 RRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPI 791
Query: 795 KTSDFMPWNVFDGKLFHQKYLQSEK 819
PW FDGKLF K L++ +
Sbjct: 792 PWEHCCPWMYFDGKLFQSKLLKASR 816
Score = 103 bits (256), Expect = 1e-21
Identities = 72/258 (27%), Positives = 115/258 (44%), Gaps = 11/258 (4%)
Query: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEHH-----RSKYPGCTPTIVVDAMCCLRYWYTP 55
MGV+G Q ++ CP V ++LA R + P ++VDA CL Y
Sbjct: 1 MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGG 60
Query: 56 --ESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREIS 113
W+ GGQW L K I+L FF+G +E+ + EWVKR+ +
Sbjct: 61 FYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQ 120
Query: 114 RIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCL 173
+I ++++ P + F P +A R AL + S+++ EV + ++
Sbjct: 121 QIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH 180
Query: 174 GILGEDTDYLIYDTCPYFSISELCL----ESLDTVMLCREKLCESLGLCVADLPLLACLL 229
G++ D+DY + + YFS L L +SL T ++ + L L P+ A LL
Sbjct: 181 GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALL 240
Query: 230 GNDIIPEGMFESFRYKCL 247
GN I+P+ SF + L
Sbjct: 241 GNHILPDEDLASFHWSLL 258
>gi|157388908 hypothetical protein LOC54954 [Homo sapiens]
Length = 1096
Score = 115 bits (289), Expect = 1e-25
Identities = 81/262 (30%), Positives = 123/262 (46%), Gaps = 21/262 (8%)
Query: 575 EILKVARTHHVQAESY-LVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLL 633
E+L+VA H + Y +Y++++ GEI+ +EDE + LP A ++R RQ VY +L
Sbjct: 606 EVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVL 665
Query: 634 LEDCQD--------------VTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLK 679
+ V + +KEW Y G + P+LV L P+LK
Sbjct: 666 FSLAETQRKMERLAMRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFR-EWTCPNLK 724
Query: 680 ILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL--CCLLIYLFVQVDTLCLE 737
LWL + E + RR+ LAC S + L P L CC+L Y+ L
Sbjct: 725 KLWLGKAVEDKNRRMRAFLACMK-SDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILH 783
Query: 738 --DLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWK 795
+L F+AQA+ Q +L L+ + ++ R +QL +L + G+ T + N ACG P
Sbjct: 784 RHELDTFLAQAVSTQLYEPDRLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVP 843
Query: 796 TSDFMPWNVFDGKLFHQKYLQS 817
PW FDGKLF K +++
Sbjct: 844 WEHCCPWIYFDGKLFQSKLIKA 865
Score = 88.6 bits (218), Expect = 2e-17
Identities = 69/272 (25%), Positives = 116/272 (42%), Gaps = 22/272 (8%)
Query: 29 HHRSKYPGCTPT-------------IVVDAMCCLRYWYT--PESWICGGQWRE---YFSA 70
HH PG P ++VDA L Y W+CGGQW Y SA
Sbjct: 93 HHGQAQPGLHPPLPPPPPPQLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSA 152
Query: 71 LRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIKSHKEQPGRNM 130
L G++L+ F G + +D+ EW +R + I ++ + P R
Sbjct: 153 LCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAW 212
Query: 131 FFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDTDYLIYDTCPY 190
F P+ L+ R AL + SL++ EV ++ ++ G+L D++Y +Y+ Y
Sbjct: 213 FLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSY 272
Query: 191 FSISELCL----ESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFESFRYKC 246
+S L L ++L T +++ + LGL + P+ A LLGN I+P+ +F +
Sbjct: 273 YSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSL 332
Query: 247 LSSYTSVKENFDKKGNIILAVSDHISKVLYLY 278
L + + ++L D + K + Y
Sbjct: 333 LGPEHPLASLKVRAHQLVLPPCDVVIKAVSEY 364
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 57.0 bits (136), Expect = 8e-08
Identities = 67/295 (22%), Positives = 99/295 (33%), Gaps = 23/295 (7%)
Query: 301 MASYLLPGQKSPWFFQKPKGVITLDKQ----VISTSSDAESREEVPMCSDAESRQEVP-- 354
+A+ P ++P Q P T ++ V S S+ S EE P+ S +E
Sbjct: 528 LAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAE 587
Query: 355 --------MCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSD 406
+ S E P P +E P P P +E P P E P
Sbjct: 588 EASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 647
Query: 407 PEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTG 466
P P +E P P +E P P +E P S P +E P+ P
Sbjct: 648 PPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDV 707
Query: 467 PESRQEVPMYTGPESRQEVLIRTDP----ESRQEIMCTGHESKQEVPICTDPISKQEDSM 522
P V ++ P L+ T+ E+ E+ E E + +S + S
Sbjct: 708 PAEEASVDKHSPPAD----LLLTEEFPIGEASAEVSPPPSEQTPEDEALVENVSTEFQSP 763
Query: 523 CTHAEINQKL-PVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEI 576
KL V + E K E + N +K TN G ++ V E+
Sbjct: 764 QVAGIPAVKLGSVVLEGEAKFEEVSKINSVLKDLSNTNDGQAPTLEIESVFHIEL 818
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/215 (25%), Positives = 86/215 (40%), Gaps = 44/215 (20%)
Query: 314 FFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRRE-VPVYTDSE 372
+ QK + ++ TS +S+E + + +S Q+ P +R + P + SE
Sbjct: 1205 YLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPT----PSAREDPAPKKSSSE 1260
Query: 373 PRQEVPMCSDPE------PRQEVPTCTGPESRREVPMCSDPE---PRQEVPMCTGPEARQ 423
P P+ E P E T P SR+ S P P Q P TGP
Sbjct: 1261 PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQ--PPTTGP---- 1314
Query: 424 EVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQ 483
PR+EVP T SEP+++ P S P Q P R +P+ P+ ++
Sbjct: 1315 ---------PRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAP--RPSIPVKQKPKEKE 1363
Query: 484 EVLIRTDPESRQE---------IMCTGHESKQEVP 509
+ P ++QE + G+ SKQ++P
Sbjct: 1364 ----KPPPVNKQENAGTLNILSTLSNGNSSKQKIP 1394
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 47.8 bits (112), Expect = 5e-05
Identities = 64/255 (25%), Positives = 105/255 (41%), Gaps = 48/255 (18%)
Query: 352 EVPMCTGPESRREVPVYTDSE------------PRQEVPMC----SDPEPRQ--EVPTCT 393
EVP PE ++ VPV E P ++VP+ P P + EVP
Sbjct: 9952 EVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKP 10011
Query: 394 GPESRREVPMC----SDPEPRQEVPMCTGPEARQEVPMYTDSE-PRQEVPMYTDSEPRQE 448
PE + VP+ + P EVP PE + VP E P +VP P++
Sbjct: 10012 VPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVP----EVPKKL 10067
Query: 449 VPMYTGSEP---RQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESK 505
+P P + E P P+ R+ VP+ +EVL + +E++ E +
Sbjct: 10068 IPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVL---PEEE 10124
Query: 506 QEVPICTDPISKQEDSMCTHAEI----------NQKLPVATDFEFKLEALMCTNPEIKQE 555
+ +P + + ++E+ + EI + +P +F + E L PE+K +
Sbjct: 10125 EVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVL----PEVKPK 10180
Query: 556 DPTNVG-PEVKQQVT 569
P PE+K++VT
Sbjct: 10181 VPVPAPVPEIKKKVT 10195
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/143 (29%), Positives = 61/143 (42%), Gaps = 18/143 (12%)
Query: 352 EVPMCTGPESRREVPVYTDSEPRQEVPMCSDPE-PRQEVPTC-TGPESRREVPMCSDPE- 408
EVP PE ++VP+ +P E P PE P++ VP + EVP PE
Sbjct: 10723 EVPKEVVPE--KKVPLVVPKKP--EAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEV 10778
Query: 409 PR----QEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMY 464
P+ +E P PE + P EP +E+ + P +E P+ E EVP
Sbjct: 10779 PKKPVLEEKPAVPVPERAESPPPEVYEEP-EEIAPEEEIAPEEEKPVPVAEEEEPEVPPP 10837
Query: 465 TGPES------RQEVPMYTGPES 481
PE ++VP+ PE+
Sbjct: 10838 AVPEEPKKIIPEKKVPVIKKPEA 10860
Score = 36.2 bits (82), Expect = 0.14
Identities = 47/204 (23%), Positives = 78/204 (38%), Gaps = 29/204 (14%)
Query: 319 KGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVP 378
K ++T +K ++ S E +VP + + +EV P+ P++ VP
Sbjct: 9266 KEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVP 9325
Query: 379 MCSDPEP-----------RQEVPTCTGPESRREVPMCSDPE-PRQEVP-MCTGPEARQEV 425
P P EVP PE + VP+ E P +VP + G +++
Sbjct: 9326 EEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKI 9385
Query: 426 PMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQE-----------VPMYTGPESRQEVP 474
+ T E + P P+++VP PR+E +P PE + VP
Sbjct: 9386 TIVTQRE--ESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVP 9443
Query: 475 M---YTGPESRQEVLIRTDPESRQ 495
+ P R EV +T E ++
Sbjct: 9444 VPVAKKAPPPRAEVSKKTVVEEKR 9467
Score = 36.2 bits (82), Expect = 0.14
Identities = 69/317 (21%), Positives = 117/317 (36%), Gaps = 55/317 (17%)
Query: 281 EKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESRE- 339
EKK+ ++P P P K P + PK V+ K + + +
Sbjct: 10731 EKKVPLVVPKKPEA------------PPAKVP---EVPKEVVPEKKVAVPKKPEVPPAKV 10775
Query: 340 -EVPMCSDAESRQEVPMCTGPESRREVP--VYTDSE---------PRQEVPMCSDPEPRQ 387
EVP E + VP+ PE P VY + E P +E P+ E
Sbjct: 10776 PEVPKKPVLEEKPAVPV---PERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEP 10832
Query: 388 EVPTCTGPES------RREVPMCSDPE---PRQEVP--MCTGPEARQEVPMYTDSEPRQE 436
EVP PE ++VP+ PE P++ P + P+ + P + P+++
Sbjct: 10833 EVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED 10892
Query: 437 VP---MYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMY---TGPESRQEVLIRT- 489
V + P+++VP + E+ P ++V PE ++EV++++
Sbjct: 10893 VKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSV 10952
Query: 490 ------DPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLE 543
+ E + E K VP P +E + T + +K+P T
Sbjct: 10953 LRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKP 11012
Query: 544 ALMCTNPEIKQEDPTNV 560
A+ PE K + V
Sbjct: 11013 AIPLPAPEPKPKPEAEV 11029
Score = 30.4 bits (67), Expect = 7.8
Identities = 51/214 (23%), Positives = 81/214 (37%), Gaps = 30/214 (14%)
Query: 288 LPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVIST----SSDAESREEVPM 343
+P P A+ K + + P +SP P V K+V+ ++ + E P+
Sbjct: 10553 VPEVPKAAVPEKKVPEAIPPKPESP-----PPEVPEAPKEVVPEKKVPAAPPKKPEVTPV 10607
Query: 344 CSDAESRQEVP---MCTGPESRREVPVYTDSE-PRQEVPMCSDPEPRQEVPTCTGPESRR 399
++ VP + P + EVP E P+ VP PE P PE
Sbjct: 10608 KVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFE 10667
Query: 400 EVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQ 459
E + EP EV P A +V + P++ V P ++ P +P
Sbjct: 10668 EPEEVALEEPPAEVVEEPEPAAPPQVTV----PPKKPV-------PEKKAPAVVAKKP-- 10714
Query: 460 EVPMYTGPESRQEVPMYTGPESRQEVLIRTDPES 493
E+P P EVP PE + +++ PE+
Sbjct: 10715 ELP----PVKVPEVPKEVVPEKKVPLVVPKKPEA 10744
>gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo
sapiens]
Length = 1198
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/150 (24%), Positives = 58/150 (38%), Gaps = 1/150 (0%)
Query: 325 DKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPE 384
D ++ T +D E RE ++ P P +E+P D P ++ P +P
Sbjct: 677 DSKMFETEAD-EKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPA 735
Query: 385 PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSE 444
P QE + + P D P ++VP C P Q++ D QE + D
Sbjct: 736 PSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPL 795
Query: 445 PRQEVPMYTGSEPRQEVPMYTGPESRQEVP 474
+++P S R P P S+ +P
Sbjct: 796 LTKDLPAIQESPTRDLPPCQDLPPSQVSLP 825
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/166 (25%), Positives = 68/166 (40%), Gaps = 21/166 (12%)
Query: 305 LLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRRE 364
L PGQ P P G Q +S D+ + E P DA ++VP C +E
Sbjct: 716 LPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPC------QE 769
Query: 365 VPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQE 424
P D P Q++P +P P Q+ P +++P + P +++P C Q+
Sbjct: 770 PPPAQDLSPCQDLPAGQEPLPHQD------PLLTKDLPAIQE-SPTRDLPPC------QD 816
Query: 425 VPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESR 470
+P S P + + D+ ++ TG P P + PE R
Sbjct: 817 LPPSQVSLPAK--ALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVR 860
Score = 39.7 bits (91), Expect = 0.013
Identities = 37/179 (20%), Positives = 72/179 (40%), Gaps = 15/179 (8%)
Query: 336 ESREEVPMC-SDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTG 394
E ++ V C S+ ++Q+ + P+S+ T+++ ++E+ + P E
Sbjct: 652 EQKKRVCWCLSENIAKQQQLAASPPDSKM---FETEADEKREMALEEGKGPGAE------ 702
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG 454
+ P +P P QE+P ++ P + P QE DS + P
Sbjct: 703 -----DSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPD 757
Query: 455 SEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTD 513
+ P ++VP P Q++ + QE L DP +++ +++P C D
Sbjct: 758 APPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQD 816
Score = 37.7 bits (86), Expect = 0.049
Identities = 35/137 (25%), Positives = 59/137 (43%), Gaps = 14/137 (10%)
Query: 322 ITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGP-ESRREVPVYTDSEPRQEVPMC 380
I +Q+ ++ D++ E ++A+ ++E+ + G + P + P QE+P
Sbjct: 665 IAKQQQLAASPPDSKMFE-----TEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPG 719
Query: 381 SDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMY 440
D P ++ P+ P +E D + P GP+A P D P QE P
Sbjct: 720 QDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSP--PGPDA----PPSKDVPPCQEPPPA 773
Query: 441 TDSEPRQEVPMYTGSEP 457
D P Q++P G EP
Sbjct: 774 QDLSPCQDLP--AGQEP 788
>gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo
sapiens]
Length = 917
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/150 (24%), Positives = 58/150 (38%), Gaps = 1/150 (0%)
Query: 325 DKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPE 384
D ++ T +D E RE ++ P P +E+P D P ++ P +P
Sbjct: 396 DSKMFETEAD-EKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPA 454
Query: 385 PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSE 444
P QE + + P D P ++VP C P Q++ D QE + D
Sbjct: 455 PSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPL 514
Query: 445 PRQEVPMYTGSEPRQEVPMYTGPESRQEVP 474
+++P S R P P S+ +P
Sbjct: 515 LTKDLPAIQESPTRDLPPCQDLPPSQVSLP 544
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/166 (25%), Positives = 68/166 (40%), Gaps = 21/166 (12%)
Query: 305 LLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRRE 364
L PGQ P P G Q +S D+ + E P DA ++VP C +E
Sbjct: 435 LPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPC------QE 488
Query: 365 VPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQE 424
P D P Q++P +P P Q+ P +++P + P +++P C Q+
Sbjct: 489 PPPAQDLSPCQDLPAGQEPLPHQD------PLLTKDLPAIQE-SPTRDLPPC------QD 535
Query: 425 VPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESR 470
+P S P + + D+ ++ TG P P + PE R
Sbjct: 536 LPPSQVSLPAK--ALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVR 579
Score = 39.7 bits (91), Expect = 0.013
Identities = 37/179 (20%), Positives = 72/179 (40%), Gaps = 15/179 (8%)
Query: 336 ESREEVPMC-SDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTG 394
E ++ V C S+ ++Q+ + P+S+ T+++ ++E+ + P E
Sbjct: 371 EQKKRVCWCLSENIAKQQQLAASPPDSKM---FETEADEKREMALEEGKGPGAE------ 421
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG 454
+ P +P P QE+P ++ P + P QE DS + P
Sbjct: 422 -----DSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPD 476
Query: 455 SEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTD 513
+ P ++VP P Q++ + QE L DP +++ +++P C D
Sbjct: 477 APPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQD 535
Score = 37.7 bits (86), Expect = 0.049
Identities = 35/137 (25%), Positives = 59/137 (43%), Gaps = 14/137 (10%)
Query: 322 ITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGP-ESRREVPVYTDSEPRQEVPMC 380
I +Q+ ++ D++ E ++A+ ++E+ + G + P + P QE+P
Sbjct: 384 IAKQQQLAASPPDSKMFE-----TEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPG 438
Query: 381 SDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMY 440
D P ++ P+ P +E D + P GP+A P D P QE P
Sbjct: 439 QDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSP--PGPDA----PPSKDVPPCQEPPPA 492
Query: 441 TDSEPRQEVPMYTGSEP 457
D P Q++P G EP
Sbjct: 493 QDLSPCQDLP--AGQEP 507
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 46.6 bits (109), Expect = 1e-04
Identities = 67/270 (24%), Positives = 99/270 (36%), Gaps = 49/270 (18%)
Query: 334 DAESREEVPMCSDAESR------QEVPMCTGPESRREVPVYTD------------SEPRQ 375
+A EE+P+ E +E P PE+ R P + S P +
Sbjct: 431 EAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLE 490
Query: 376 EVPMCSDPE------PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYT 429
E P+ PE P + P ES P S P P E P+ PEA P +
Sbjct: 491 ESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFE 550
Query: 430 D---SEPRQEVPMYTDSE------PRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE 480
+ S P +E+P E P +E PM S P +E PM PE+ + P +
Sbjct: 551 ESPLSPPPEELPTSPPPEASRLSPPPEESPM---SPPPEESPMSPPPEASRLFPPF---- 603
Query: 481 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPIS--KQEDSMCTHAEINQ--KLPVAT 536
E + P + S+ P P+S +E M E+++ LPV +
Sbjct: 604 ---EESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660
Query: 537 DFEFKLEALMCTNPEIKQEDPTNVGPEVKQ 566
E + P +E PT+ PE +
Sbjct: 661 RLSPPPEESPLSPP--PEESPTSPPPEASR 688
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/171 (29%), Positives = 64/171 (37%), Gaps = 36/171 (21%)
Query: 339 EEVPMCSDAESRQEVPMCTGPESRREVPVYTDSE---PRQEVPMCSDPE----------- 384
EE PM E E PM PE+ R P + +S P +E P+ PE
Sbjct: 577 EESPMSPPPE---ESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDS 633
Query: 385 ----PRQEVPTCTGPESRREVPM------CSDPE------PRQEVPMCTGPEARQEVPMY 428
P +E P PE R P+ PE P +E P PEA + P
Sbjct: 634 PMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPP 693
Query: 429 TDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGP 479
DS P P + + P E + S P +E P+ PE Q P GP
Sbjct: 694 EDS-PTSPPPEDSPASPPPEDSLM--SLPLEESPLLPLPEEPQLCPRSEGP 741
Score = 31.6 bits (70), Expect = 3.5
Identities = 34/135 (25%), Positives = 52/135 (38%), Gaps = 20/135 (14%)
Query: 357 TGPESRRE----VPVYTDSEPRQEVPMCSDPEPRQEVPT---CTGPESRREVPMCSDPEP 409
TGP+ ++ +P YT + + P E PT T S +V S P P
Sbjct: 4852 TGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPP 4911
Query: 410 RQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPES 469
+ P P P +EP E+P +EP E P+ +P+ + PES
Sbjct: 4912 EEPSPP---PSPLAPSPASPPTEPLVELP----TEPLAEPPV------PSPLPLASSPES 4958
Query: 470 RQEVPMYTGPESRQE 484
+ P PE ++
Sbjct: 4959 ARPKPRARPPEEGED 4973
>gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo
sapiens]
Length = 519
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/166 (25%), Positives = 68/166 (40%), Gaps = 21/166 (12%)
Query: 305 LLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRRE 364
L PGQ P P G Q +S D+ + E P DA ++VP C +E
Sbjct: 37 LPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPC------QE 90
Query: 365 VPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQE 424
P D P Q++P +P P Q+ P +++P + P +++P C Q+
Sbjct: 91 PPPAQDLSPCQDLPAGQEPLPHQD------PLLTKDLPAIQE-SPTRDLPPC------QD 137
Query: 425 VPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESR 470
+P S P + + D+ ++ TG P P + PE R
Sbjct: 138 LPPSQVSLPAK--ALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVR 181
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/147 (23%), Positives = 56/147 (38%), Gaps = 1/147 (0%)
Query: 328 VISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQ 387
+ T +D E RE ++ P P +E+P D P ++ P +P P Q
Sbjct: 1 MFETEAD-EKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQ 59
Query: 388 EVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQ 447
E + + P D P ++VP C P Q++ D QE + D +
Sbjct: 60 EPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTK 119
Query: 448 EVPMYTGSEPRQEVPMYTGPESRQEVP 474
++P S R P P S+ +P
Sbjct: 120 DLPAIQESPTRDLPPCQDLPPSQVSLP 146
Score = 44.3 bits (103), Expect = 5e-04
Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 17/175 (9%)
Query: 339 EEVPMCSDAESRQEVPMCTGPESRREV------PVYTDSEPRQEVPMCSDPEPRQEVPTC 392
+++P D+ S QE P S ++ P D+ P ++VP C +P P Q++ C
Sbjct: 41 QDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPC 100
Query: 393 TGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMY 452
+++P +P P Q+ + A QE P D P Q++P S P + +
Sbjct: 101 ------QDLPAGQEPLPHQDPLLTKDLPAIQESPT-RDLPPCQDLPPSQVSLPAKALTED 153
Query: 453 TGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQE 507
T S ++ TG P + PE R + + Q C+G E E
Sbjct: 154 TMSS--GDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQG--CSGDEEDAE 204
Score = 38.1 bits (87), Expect = 0.038
Identities = 26/112 (23%), Positives = 44/112 (39%)
Query: 402 PMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEV 461
P +P P QE+P ++ P + P QE DS + P + P ++V
Sbjct: 26 PPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDV 85
Query: 462 PMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTD 513
P P Q++ + QE L DP +++ +++P C D
Sbjct: 86 PPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQD 137
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/217 (24%), Positives = 83/217 (38%), Gaps = 12/217 (5%)
Query: 273 KVLYLYQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVIT-LDKQVIST 331
+ +YLY + L + PL + A ++G+++ PG++ P GV + QV+
Sbjct: 651 RTVYLYPNQTGLPD--PLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPG 708
Query: 332 SSDAESREEVPMCSDAESRQEVPMCTGPESRRE-VPVYT--DSEPRQEVPMCSDPEPRQE 388
+ EE E+ + T PE++ E P YT + P + P
Sbjct: 709 VAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAAT 768
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ GP S EVP S+ EVP + + E P + P V ++ EP
Sbjct: 769 EESTEGP-SATEVPSASEEPSPSEVPFPSEEPSPSEEP-FPSVRPFPSVELFPSEEPFPS 826
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTG-PESRQE 484
EP YT VP +T P S +E
Sbjct: 827 KEPSPSEEPSASEEPYT---PSPPVPSWTELPSSGEE 860
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/217 (24%), Positives = 83/217 (38%), Gaps = 12/217 (5%)
Query: 273 KVLYLYQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVIT-LDKQVIST 331
+ +YLY + L + PL + A ++G+++ PG++ P GV + QV+
Sbjct: 651 RTVYLYPNQTGLPD--PLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPG 708
Query: 332 SSDAESREEVPMCSDAESRQEVPMCTGPESRRE-VPVYT--DSEPRQEVPMCSDPEPRQE 388
+ EE E+ + T PE++ E P YT + P + P
Sbjct: 709 VAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAAT 768
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ GP S EVP S+ EVP + + E P + P V ++ EP
Sbjct: 769 EESTEGP-SATEVPSASEEPSPSEVPFPSEEPSPSEEP-FPSVRPFPSVELFPSEEPFPS 826
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTG-PESRQE 484
EP YT VP +T P S +E
Sbjct: 827 KEPSPSEEPSASEEPYT---PSPPVPSWTELPSSGEE 860
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 43.5 bits (101), Expect = 9e-04
Identities = 49/190 (25%), Positives = 73/190 (38%), Gaps = 14/190 (7%)
Query: 339 EEVPMCSDAESRQEVPMCTGPESRREV----PVYTDSEPRQEVPMCSDPEPRQEVPTCTG 394
EE + +++Q+ P ES E P T E +E S + R E P
Sbjct: 202 EETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQAR 261
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSE-----PRQEVPMYTDSEPRQEV 449
E + P S E E P T PE +E+ E P + P + D +PR+
Sbjct: 262 LEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKST 321
Query: 450 PMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVP 509
EP +E+ + E +E T E+ E PES +EI + + + P
Sbjct: 322 DENV-PEPLEEIKL----EFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP 376
Query: 510 ICTDPISKQE 519
T P+ QE
Sbjct: 377 EETGPVLPQE 386
Score = 38.5 bits (88), Expect = 0.029
Identities = 63/266 (23%), Positives = 97/266 (36%), Gaps = 34/266 (12%)
Query: 338 REEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGP-- 395
R E+P E +S+ +Y + +P E + EP P
Sbjct: 22 RPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGG 81
Query: 396 --------ESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSE-PRQEVPMYTDSEPR 446
ES+R+VP ++P QEV T +R+ + D E P E +D EP
Sbjct: 82 TSQEGIAKESKRDVPSETEPGIHQEVKSET---SREMGEFFKDLEAPMDETHKESDLEPP 138
Query: 447 QEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQ 506
+E + E M T P+ VP E+ EV T E E++ ++
Sbjct: 139 EEAKPNVTEDVFLESAMETDPD---PVP---PTETMSEVSGATVRERNLELL------EE 186
Query: 507 EVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQ 566
E T+P +E H E + P T +F E L + E + P PE +
Sbjct: 187 E----TEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE 242
Query: 567 QV----TMVSDTEILKVARTHHVQAE 588
+ T TE + AR ++ E
Sbjct: 243 ETQRESTEKKRTEPPEQARLEFLEKE 268
Score = 33.1 bits (74), Expect = 1.2
Identities = 57/244 (23%), Positives = 94/244 (38%), Gaps = 31/244 (12%)
Query: 285 EEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTS--SDAESREEVP 342
EE P P ++L + + L P +++ F K +L++ + + E+ EE
Sbjct: 186 EETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQ 245
Query: 343 MCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVP 402
S + R E P E + P + E E P + PE +E+ E E+P
Sbjct: 246 RESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELP 305
Query: 403 MCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPM-YTDSEPRQEVPMYTGSEPRQEV 461
+ P+ P + E VP EP +E+ + + + E R+ T E E
Sbjct: 306 ERTKPDFPDHKPRKSTDE---NVP-----EPLEEIKLEFPEEESRK-----TNEETILEQ 352
Query: 462 PMYTGPESRQEV-----------PMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPI 510
PES +E+ P TGP QE+ +P+ ++ E E+P
Sbjct: 353 SEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEI----NPQVEEKTQTKPTEKILELPD 408
Query: 511 CTDP 514
T P
Sbjct: 409 ETKP 412
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/122 (27%), Positives = 54/122 (44%), Gaps = 13/122 (10%)
Query: 321 VITLDKQVISTSSDAESREEVPMCSDA------ESRQEVPMCTGPESRREVP--VYTDSE 372
+I+LD T +D + EEVP+ +D E Q + + P E P + + ++
Sbjct: 408 IISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSAD 467
Query: 373 P--RQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTD 430
P QEV + +P P + T P+ + + P SD RQ P P + E Y D
Sbjct: 468 PALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSP---EPNSPSEYCFYVD 524
Query: 431 SE 432
S+
Sbjct: 525 SD 526
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/122 (27%), Positives = 54/122 (44%), Gaps = 13/122 (10%)
Query: 321 VITLDKQVISTSSDAESREEVPMCSDA------ESRQEVPMCTGPESRREVP--VYTDSE 372
+I+LD T +D + EEVP+ +D E Q + + P E P + + ++
Sbjct: 408 IISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSAD 467
Query: 373 P--RQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTD 430
P QEV + +P P + T P+ + + P SD RQ P P + E Y D
Sbjct: 468 PALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSP---EPNSPSEYCFYVD 524
Query: 431 SE 432
S+
Sbjct: 525 SD 526
>gi|169171269 PREDICTED: similar to forkhead box L2 [Homo sapiens]
Length = 632
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/171 (18%), Positives = 58/171 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 359 LSSPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGS 418
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R + D R+ + D R
Sbjct: 419 LSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGS 478
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMC 499
+ R + P +R+ + P +R + DP +R + C
Sbjct: 479 LSSPQDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSCPQDPHTRGSLSC 529
Score = 40.8 bits (94), Expect = 0.006
Identities = 32/171 (18%), Positives = 57/171 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S D +R + D +R + P +R + D R + DP R
Sbjct: 347 LSCPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGS 406
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R + D R + D R+
Sbjct: 407 LSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRS 466
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMC 499
+ R + P +R + P +R+ + DP +R + C
Sbjct: 467 LSCPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSC 517
Score = 40.4 bits (93), Expect = 0.008
Identities = 32/171 (18%), Positives = 57/171 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S D +R + D +R + P +R + D R + DP R
Sbjct: 335 LSCPQDPHTRGSLSCPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGS 394
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R + D R + D R
Sbjct: 395 LSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGS 454
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMC 499
+ R+ + P +R + P +R + DP +R+ + C
Sbjct: 455 LSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRRSLSC 505
Score = 38.5 bits (88), Expect = 0.029
Identities = 31/166 (18%), Positives = 56/166 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 371 LSSPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGS 430
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R+ + D R + D R
Sbjct: 431 LSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGS 490
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESR 494
+ R+ + P +R + P +R + DP +R
Sbjct: 491 LSSPKDPHTRRSLSCPQDPHTRGSLSCPQDPHTRGSLSCPQDPHTR 536
Score = 38.1 bits (87), Expect = 0.038
Identities = 31/166 (18%), Positives = 54/166 (32%)
Query: 334 DAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCT 393
D +R + D +R + P +R + D R + DP R + +
Sbjct: 304 DLHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQ 363
Query: 394 GPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYT 453
P +R + DP R + P R + D R + D R +
Sbjct: 364 DPHTRGSLSSPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPK 423
Query: 454 GSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMC 499
R + P +R + P +R + DP +R+ + C
Sbjct: 424 DPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRSLSC 469
Score = 37.7 bits (86), Expect = 0.049
Identities = 31/166 (18%), Positives = 55/166 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 311 LSSPQDPHTRGSLSSPKDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQDPHTRGS 370
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R + D R + D R
Sbjct: 371 LSSPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGS 430
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESR 494
+ R + P +R + P +R+ + DP +R
Sbjct: 431 LSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTR 476
Score = 37.0 bits (84), Expect = 0.084
Identities = 31/166 (18%), Positives = 55/166 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 323 LSSPKDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQDPHTRGSLSSPQDPHTRGS 382
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R + P R + D R + D R
Sbjct: 383 LSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGS 442
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESR 494
+ R + P +R+ + P +R + DP +R
Sbjct: 443 LSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTR 488
Score = 35.0 bits (79), Expect = 0.32
Identities = 25/118 (21%), Positives = 41/118 (34%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +RR + D R + DP R
Sbjct: 431 LSSPQDPHTRGSLSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGS 490
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPR 446
+ + P +RR + DP R + P R + D R + D R
Sbjct: 491 LSSPKDPHTRRSLSCPQDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQDLHTR 548
Score = 34.3 bits (77), Expect = 0.54
Identities = 30/166 (18%), Positives = 55/166 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 383 LSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGS 442
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +R + DP R+ + P R + D R + D R+
Sbjct: 443 LSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRRS 502
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESR 494
+ R + P +R + P +R + D +R
Sbjct: 503 LSCPQDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQDLHTR 548
Score = 33.9 bits (76), Expect = 0.71
Identities = 30/165 (18%), Positives = 54/165 (32%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R + P +R + D R + DP R
Sbjct: 395 LSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGSLSSPQDPHTRGSLSSPKDPHTRGS 454
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ + P +RR + DP R + P R + D R+ + D R
Sbjct: 455 LSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGS 514
Query: 449 VPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPES 493
+ R + P +R + +R + DP +
Sbjct: 515 LSCPQDPHTRGSLSCPQDPHTRGSLSSPQDLHTRGSLSSPKDPHT 559
Score = 30.4 bits (67), Expect = 7.8
Identities = 23/123 (18%), Positives = 41/123 (33%)
Query: 329 ISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQE 388
+S+ D +R + D +R+ + P +R + D R + DP R+
Sbjct: 443 LSSPKDPHTRGSLSSPKDPHTRRSLSCPQDPHTRGSLSSPQDPHTRGSLSSPKDPHTRRS 502
Query: 389 VPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE 448
+ P +R + DP R + P R + D R + D
Sbjct: 503 LSCPQDPHTRGSLSCPQDPHTRGSLSCPQDPHTRGSLSSPQDLHTRGSLSSPKDPHTPPR 562
Query: 449 VPM 451
P+
Sbjct: 563 SPL 565
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 40.4 bits (93), Expect = 0.008
Identities = 40/166 (24%), Positives = 66/166 (39%), Gaps = 12/166 (7%)
Query: 325 DKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPM----C 380
DK + + D E E + S+ ES + + ES T+ E E P
Sbjct: 1583 DKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESEFSESETTEEESESETPSEEEES 1642
Query: 381 SDPEPRQEVPT-CTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPM 439
S PE + T G ++R+ + + +EV G R+E P EP+ E
Sbjct: 1643 STPESEESESTESEGEKARKNIVLARRRPMVEEVKEVKG---RKEEPQEEQKEPKMEEEE 1699
Query: 440 YTDSEPRQEVPMYTGSEPR-QEVPMYTGPESRQEVPMYTGPESRQE 484
+++ E P+ ++P Q++P ES + G ES +E
Sbjct: 1700 HSEEEESGPAPVEESTDPEAQDIPEEGSAES---ASVEGGVESEEE 1742
>gi|39995071 exonuclease 1 isoform b [Homo sapiens]
Length = 846
Score = 40.0 bits (92), Expect = 0.010
Identities = 62/256 (24%), Positives = 92/256 (35%), Gaps = 41/256 (16%)
Query: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEH-HRSKYPGCTPTIVVDAMCCLRYWYTP--ES 57
MG++GL F+ KE +E H KY G + VD C L E
Sbjct: 1 MGIQGLLQFI-------------KEASEPIHVRKYKG--QVVAVDTYCWLHKGAIACAEK 45
Query: 58 WICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFH 117
G Y FV + GIK I FDG K++ RR + + +
Sbjct: 46 LAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQ 105
Query: 118 YIKSHKEQPGRNMFF----IPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCL 173
++ K R F I +A A ++ G + L + EAD ++A
Sbjct: 106 LLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQ 165
Query: 174 GILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDI 233
I+ ED+D L + V+L ++ L + A L + C D+
Sbjct: 166 AIITEDSDLLAF--------------GCKKVILKMDQFGNGLEIDQARLGM--CRQLGDV 209
Query: 234 IPEGMFESFRYKCLSS 249
E E FRY C+ S
Sbjct: 210 FTE---EKFRYMCILS 222
>gi|39995069 exonuclease 1 isoform a [Homo sapiens]
Length = 803
Score = 40.0 bits (92), Expect = 0.010
Identities = 62/256 (24%), Positives = 92/256 (35%), Gaps = 41/256 (16%)
Query: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEH-HRSKYPGCTPTIVVDAMCCLRYWYTP--ES 57
MG++GL F+ KE +E H KY G + VD C L E
Sbjct: 1 MGIQGLLQFI-------------KEASEPIHVRKYKG--QVVAVDTYCWLHKGAIACAEK 45
Query: 58 WICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFH 117
G Y FV + GIK I FDG K++ RR + + +
Sbjct: 46 LAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQ 105
Query: 118 YIKSHKEQPGRNMFF----IPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCL 173
++ K R F I +A A ++ G + L + EAD ++A
Sbjct: 106 LLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQ 165
Query: 174 GILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDI 233
I+ ED+D L + V+L ++ L + A L + C D+
Sbjct: 166 AIITEDSDLLAF--------------GCKKVILKMDQFGNGLEIDQARLGM--CRQLGDV 209
Query: 234 IPEGMFESFRYKCLSS 249
E E FRY C+ S
Sbjct: 210 FTE---EKFRYMCILS 222
>gi|18491016 exonuclease 1 isoform b [Homo sapiens]
Length = 846
Score = 40.0 bits (92), Expect = 0.010
Identities = 62/256 (24%), Positives = 92/256 (35%), Gaps = 41/256 (16%)
Query: 1 MGVRGLQGFVGSTCPHICTVVNFKELAEH-HRSKYPGCTPTIVVDAMCCLRYWYTP--ES 57
MG++GL F+ KE +E H KY G + VD C L E
Sbjct: 1 MGIQGLLQFI-------------KEASEPIHVRKYKG--QVVAVDTYCWLHKGAIACAEK 45
Query: 58 WICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFH 117
G Y FV + GIK I FDG K++ RR + + +
Sbjct: 46 LAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQ 105
Query: 118 YIKSHKEQPGRNMFF----IPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCL 173
++ K R F I +A A ++ G + L + EAD ++A
Sbjct: 106 LLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQ 165
Query: 174 GILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDI 233
I+ ED+D L + V+L ++ L + A L + C D+
Sbjct: 166 AIITEDSDLLAF--------------GCKKVILKMDQFGNGLEIDQARLGM--CRQLGDV 209
Query: 234 IPEGMFESFRYKCLSS 249
E E FRY C+ S
Sbjct: 210 FTE---EKFRYMCILS 222
>gi|7657577 SHP2-interacting transmembrane adaptor protein [Homo
sapiens]
Length = 196
Score = 40.0 bits (92), Expect = 0.010
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 6/81 (7%)
Query: 360 ESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDP----EPRQEVPM 415
ES EVP+Y + Q + DPEP Q+ PT GP E MC P+ +P
Sbjct: 82 ESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPG 141
Query: 416 CTGPEARQEVPMYTDSEPRQE 436
P EV + DSEP+ +
Sbjct: 142 PGTPVKYSEVVL--DSEPKSQ 160
Score = 32.7 bits (73), Expect = 1.6
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 8/96 (8%)
Query: 420 EARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG-SEPRQEVPMYTGPESRQ---EVPM 475
E+ +EVP+Y + Q + D EP Q+ P G + +EV YT + R +P
Sbjct: 82 ESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPG 141
Query: 476 YTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPIC 511
P EV++ ++P+S+ +G E + +C
Sbjct: 142 PGTPVKYSEVVLDSEPKSQ----ASGPEPELYASVC 173
Score = 30.4 bits (67), Expect = 7.8
Identities = 34/117 (29%), Positives = 46/117 (39%), Gaps = 24/117 (20%)
Query: 336 ESREEVP------------MCSDAESRQEVPMCTGP-ESRREVPVYTDSE---PRQEVPM 379
ES EEVP + D E Q+ P GP + EV YT + P+ +P
Sbjct: 82 ESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPG 141
Query: 380 CSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGP-EARQEVP--MYTDSEP 433
P EV + P+S+ S PEP +C AR P Y +S+P
Sbjct: 142 PGTPVKYSEVVLDSEPKSQ-----ASGPEPELYASVCAQTRRARASFPDQAYANSQP 193
>gi|150378528 G protein-coupled receptor associated sorting protein
1 [Homo sapiens]
Length = 1395
Score = 38.9 bits (89), Expect = 0.022
Identities = 35/186 (18%), Positives = 72/186 (38%), Gaps = 15/186 (8%)
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG 454
PE + + E +VP+ P+ R + + + P+ + + + + E G
Sbjct: 14 PEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGG 73
Query: 455 SEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPIC-TD 513
+ P+ + ++E M+ P E L +T+ S+ I+ + S V + T
Sbjct: 74 ARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTK 133
Query: 514 PISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVG------PEVKQQ 567
+S+ + + T E + F+ P + ++ TN+G P KQ+
Sbjct: 134 YLSEDRELVNTDTESFPRRKAHYQAGFQ--------PSFRSKEETNMGSWCCPRPTSKQE 185
Query: 568 VTMVSD 573
+ SD
Sbjct: 186 ASPNSD 191
>gi|150378489 G protein-coupled receptor associated sorting protein
1 [Homo sapiens]
Length = 1395
Score = 38.9 bits (89), Expect = 0.022
Identities = 35/186 (18%), Positives = 72/186 (38%), Gaps = 15/186 (8%)
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG 454
PE + + E +VP+ P+ R + + + P+ + + + + E G
Sbjct: 14 PEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGG 73
Query: 455 SEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPIC-TD 513
+ P+ + ++E M+ P E L +T+ S+ I+ + S V + T
Sbjct: 74 ARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTK 133
Query: 514 PISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVG------PEVKQQ 567
+S+ + + T E + F+ P + ++ TN+G P KQ+
Sbjct: 134 YLSEDRELVNTDTESFPRRKAHYQAGFQ--------PSFRSKEETNMGSWCCPRPTSKQE 185
Query: 568 VTMVSD 573
+ SD
Sbjct: 186 ASPNSD 191
>gi|103472136 G protein-coupled receptor associated sorting protein
1 [Homo sapiens]
Length = 1395
Score = 38.9 bits (89), Expect = 0.022
Identities = 35/186 (18%), Positives = 72/186 (38%), Gaps = 15/186 (8%)
Query: 395 PESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTG 454
PE + + E +VP+ P+ R + + + P+ + + + + E G
Sbjct: 14 PEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGG 73
Query: 455 SEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPIC-TD 513
+ P+ + ++E M+ P E L +T+ S+ I+ + S V + T
Sbjct: 74 ARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTK 133
Query: 514 PISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVG------PEVKQQ 567
+S+ + + T E + F+ P + ++ TN+G P KQ+
Sbjct: 134 YLSEDRELVNTDTESFPRRKAHYQAGFQ--------PSFRSKEETNMGSWCCPRPTSKQE 185
Query: 568 VTMVSD 573
+ SD
Sbjct: 186 ASPNSD 191
>gi|51702248 G protein-coupled receptor associated sorting protein 2
[Homo sapiens]
Length = 838
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/136 (19%), Positives = 50/136 (36%), Gaps = 2/136 (1%)
Query: 359 PESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTG 418
PE + V E +VP+ P+ R + TG + E P+ E +G
Sbjct: 14 PEKKAGEEVIAGPERENDVPLVVRPKVRTQ--ATTGARPKTETKSVPAARPKTEAQAMSG 71
Query: 419 PEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTG 478
+ EV + + P+ E T + P+ + G+ + + G + E +
Sbjct: 72 ARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQ 131
Query: 479 PESRQEVLIRTDPESR 494
E E + + + S+
Sbjct: 132 SEFGTEAVSQAEGVSQ 147
Score = 37.0 bits (84), Expect = 0.084
Identities = 22/121 (18%), Positives = 43/121 (35%), Gaps = 2/121 (1%)
Query: 348 ESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDP 407
E + + GPE +VP+ P+ + P+ E + + E S
Sbjct: 15 EKKAGEEVIAGPERENDVPLVV--RPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGA 72
Query: 408 EPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGP 467
P+ EV + G + E T + P+ + + + + G+ P+ E +
Sbjct: 73 RPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQS 132
Query: 468 E 468
E
Sbjct: 133 E 133
>gi|19923967 G protein-coupled receptor associated sorting protein 2
[Homo sapiens]
Length = 838
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/136 (19%), Positives = 50/136 (36%), Gaps = 2/136 (1%)
Query: 359 PESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTG 418
PE + V E +VP+ P+ R + TG + E P+ E +G
Sbjct: 14 PEKKAGEEVIAGPERENDVPLVVRPKVRTQ--ATTGARPKTETKSVPAARPKTEAQAMSG 71
Query: 419 PEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTG 478
+ EV + + P+ E T + P+ + G+ + + G + E +
Sbjct: 72 ARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQ 131
Query: 479 PESRQEVLIRTDPESR 494
E E + + + S+
Sbjct: 132 SEFGTEAVSQAEGVSQ 147
Score = 37.0 bits (84), Expect = 0.084
Identities = 22/121 (18%), Positives = 43/121 (35%), Gaps = 2/121 (1%)
Query: 348 ESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDP 407
E + + GPE +VP+ P+ + P+ E + + E S
Sbjct: 15 EKKAGEEVIAGPERENDVPLVV--RPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGA 72
Query: 408 EPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGP 467
P+ EV + G + E T + P+ + + + + G+ P+ E +
Sbjct: 73 RPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQS 132
Query: 468 E 468
E
Sbjct: 133 E 133
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 38.5 bits (88), Expect = 0.029
Identities = 40/163 (24%), Positives = 64/163 (39%), Gaps = 25/163 (15%)
Query: 339 EEVPMCSDAESRQEVPMCTGPESRREVP------VYTDSEPRQEV--------PMCSDPE 384
+E P + E P P S R + V DS PRQ P P
Sbjct: 521 KEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPH 580
Query: 385 PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSE 444
P +E T PE E P + P +E P R+EV ++EV + +
Sbjct: 581 PHEEATTL--PE---EAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP 635
Query: 445 PRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLI 487
P++EV P++EVP +++ P+ P+S++ + +
Sbjct: 636 PKEEVA------PKEEVPPIERAFAQKTRPIKPPPDSQETLAL 672
Score = 32.3 bits (72), Expect = 2.1
Identities = 49/213 (23%), Positives = 78/213 (36%), Gaps = 41/213 (19%)
Query: 324 LDKQVISTSSDAESREEVPMCSDAESRQEVPMCTG---PESRREVPVYTDSEPRQEVPMC 380
L ++ +ST D + S E+ Q+V P S+ E +T P + P
Sbjct: 490 LSEEEVSTRDDIQFHH----FSSEEALQKVKYFVAKEDPSSQEEA--HTPEAPPPQPPSS 543
Query: 381 SDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMY 440
+ G S R+ + S P R P P +E + E P
Sbjct: 544 ERCLGEMKCTLVRGDSSPRQAELKSGPASR---PALEKPHPHEEATTLPE-----EAPSN 595
Query: 441 TDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCT 500
+ P +E P P ++ P+ R+EV G S++EV ++ + ++E+
Sbjct: 596 DERTPEEEAP------PNEQRPL------REEVLPKEGVASKEEVTLKEELPPKEEV--- 640
Query: 501 GHESKQEVPIC-------TDPISKQEDSMCTHA 526
K+EVP T PI DS T A
Sbjct: 641 --APKEEVPPIERAFAQKTRPIKPPPDSQETLA 671
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 38.5 bits (88), Expect = 0.029
Identities = 40/163 (24%), Positives = 64/163 (39%), Gaps = 25/163 (15%)
Query: 339 EEVPMCSDAESRQEVPMCTGPESRREVP------VYTDSEPRQEV--------PMCSDPE 384
+E P + E P P S R + V DS PRQ P P
Sbjct: 410 KEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPH 469
Query: 385 PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSE 444
P +E T PE E P + P +E P R+EV ++EV + +
Sbjct: 470 PHEEATTL--PE---EAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP 524
Query: 445 PRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLI 487
P++EV P++EVP +++ P+ P+S++ + +
Sbjct: 525 PKEEVA------PKEEVPPIERAFAQKTRPIKPPPDSQETLAL 561
Score = 32.3 bits (72), Expect = 2.1
Identities = 49/213 (23%), Positives = 78/213 (36%), Gaps = 41/213 (19%)
Query: 324 LDKQVISTSSDAESREEVPMCSDAESRQEVPMCTG---PESRREVPVYTDSEPRQEVPMC 380
L ++ +ST D + S E+ Q+V P S+ E +T P + P
Sbjct: 379 LSEEEVSTRDDIQFHH----FSSEEALQKVKYFVAKEDPSSQEEA--HTPEAPPPQPPSS 432
Query: 381 SDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMY 440
+ G S R+ + S P R P P +E + E P
Sbjct: 433 ERCLGEMKCTLVRGDSSPRQAELKSGPASR---PALEKPHPHEEATTLPE-----EAPSN 484
Query: 441 TDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCT 500
+ P +E P P ++ P+ R+EV G S++EV ++ + ++E+
Sbjct: 485 DERTPEEEAP------PNEQRPL------REEVLPKEGVASKEEVTLKEELPPKEEV--- 529
Query: 501 GHESKQEVPIC-------TDPISKQEDSMCTHA 526
K+EVP T PI DS T A
Sbjct: 530 --APKEEVPPIERAFAQKTRPIKPPPDSQETLA 560
>gi|118918411 zinc finger protein 777 [Homo sapiens]
Length = 831
Score = 38.5 bits (88), Expect = 0.029
Identities = 40/172 (23%), Positives = 67/172 (38%), Gaps = 26/172 (15%)
Query: 396 ESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGS 455
E++R P+ P++E +E + P +E+P + + PRQ T S
Sbjct: 2 ENQRSSPLSFPSVPQEETLRQAPAGLPRETLFQSRVLPPKEIPSLSPTIPRQGSLPQTSS 61
Query: 456 EPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDP- 514
P+QE R + GP + S QE G + QE P
Sbjct: 62 APKQET------SGRMPHVLQKGPS------LLCSAASEQETSLQGPLASQEGTQYPPPA 109
Query: 515 ISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQ 566
++QE S+ +H+ +Q+ PV +PE ++DP + P V +
Sbjct: 110 AAEQEVSLLSHSPHHQEAPV-------------HSPEAPEKDPLTLSPTVPE 148
Score = 32.0 bits (71), Expect = 2.7
Identities = 24/105 (22%), Positives = 45/105 (42%), Gaps = 9/105 (8%)
Query: 330 STSSDAESREEVPMCSD--------AESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCS 381
S +S+ E+ + P+ S A + QEV + + +E PV++ P ++ S
Sbjct: 84 SAASEQETSLQGPLASQEGTQYPPPAAAEQEVSLLSHSPHHQEAPVHSPEAPEKDPLTLS 143
Query: 382 DPEPRQEV-PTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEV 425
P ++ P P S+++ P ++E P+ T R V
Sbjct: 144 PTVPETDMDPLLQSPVSQKDTPFQISSAVQKEQPLPTAEITRLAV 188
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 38.1 bits (87), Expect = 0.038
Identities = 45/232 (19%), Positives = 73/232 (31%), Gaps = 24/232 (10%)
Query: 331 TSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVP 390
T++D S + VP+ T P E ++ + P+ + E
Sbjct: 2380 TTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPT 2439
Query: 391 TCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQE-- 448
T G S P P +P+ T P E + + PM T +E
Sbjct: 2440 TAEGT-SIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPT 2498
Query: 449 ------VPMYTGSEPRQ---EVPMYTGPESRQEV------------PMYTGPESRQEVLI 487
VP+ T SE +P+ T P + E P+ T E
Sbjct: 2499 TAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATS 2558
Query: 488 RTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFE 539
G + +P+ T P++ E S + ++ +PV T E
Sbjct: 2559 AEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTE 2610
Score = 34.7 bits (78), Expect = 0.42
Identities = 48/260 (18%), Positives = 75/260 (28%), Gaps = 22/260 (8%)
Query: 328 VISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQ 387
V+S+ S V + + E T E +P T SE P
Sbjct: 3176 VVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGT-SIPTSTPSEGMT---------PLT 3225
Query: 388 EVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQ 447
VP P + E + S P+ T EA P + P S P
Sbjct: 3226 SVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPS-EGSTPLT 3284
Query: 448 EVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQE 507
+P+ T + E + + P+ T ++ I G
Sbjct: 3285 SMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTN 3344
Query: 508 VPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPT--------- 558
+ T P+ E S + ++ PV T E L I P+
Sbjct: 3345 MSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASM 3404
Query: 559 --NVGPEVKQQVTMVSDTEI 576
+ P V +V +S T +
Sbjct: 3405 PVSTTPVVSSEVNTLSTTPV 3424
Score = 33.1 bits (74), Expect = 1.2
Identities = 35/171 (20%), Positives = 57/171 (33%), Gaps = 23/171 (13%)
Query: 385 PRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQE--------VPMYTDSE---P 433
P VP T P E S P+ T EA +P SE P
Sbjct: 2398 PLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTP 2457
Query: 434 RQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPES 493
+P+ T E + + PM T E+ + P + +++++ S
Sbjct: 2458 LASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEAS------SSPTTAEDIVVPISTAS 2511
Query: 494 RQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEA 544
+ T +P+ T P++ E S + ++ PV T E A
Sbjct: 2512 EGSTLLTS------IPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSA 2556
Score = 32.7 bits (73), Expect = 1.6
Identities = 41/234 (17%), Positives = 75/234 (32%), Gaps = 16/234 (6%)
Query: 307 PGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVP 366
PG++S L ST S P+ + AE+ G R P
Sbjct: 2687 PGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTP 2746
Query: 367 VYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVP 426
S P + + + P E T + +P+ + E + P +
Sbjct: 2747 S-DGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEAS------SSPTTAEVTS 2799
Query: 427 MYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPR-QEVPMYTGPESRQEVPMYTGPESRQEV 485
M T + P+ S P P+ + P+ T + P + + +
Sbjct: 2800 MPTSTPSETSTPL--TSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGI 2857
Query: 486 LIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFE 539
++ S + T +P+ T P++ E S + ++ +PV T E
Sbjct: 2858 VVPISTASEGSTLLTS------IPVSTTPVASSEASTLSTTPVDTSIPVTTSTE 2905
Score = 32.3 bits (72), Expect = 2.1
Identities = 49/247 (19%), Positives = 86/247 (34%), Gaps = 34/247 (13%)
Query: 322 ITLDKQVISTSSDAESREEVPMCSDAESRQ---EVPMCTGPESRREVPVYTDSEPRQEVP 378
+T + S+ + AE +P+ + E R + + T P + E + + P
Sbjct: 2959 VTTSAEASSSPTTAEGTS-MPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTP 3017
Query: 379 MCSDPEPRQEVPTCTGPESRREVPMCSDPE---PRQEVPMCTGPEARQEVPMYTDSEPRQ 435
+ + E T G +P+ + E P +P+ T P A E + +
Sbjct: 3018 VTTSTEASSSPTTAEGTG----IPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDS 3073
Query: 436 EVPMYTDSEPRQE--------VPMYT---GSEPRQEVPMYTGPESRQEVPMYTGPESRQE 484
P+ T +E +P+ T GS P VP+ T P + + +
Sbjct: 3074 NSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTS 3133
Query: 485 VLIRTDPESRQE-------IMCTGHESKQEVPICTDPIS-----KQEDSMCTHAEINQKL 532
+ T E+ M T S+ P+ P+S EDS + ++
Sbjct: 3134 TPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTST 3193
Query: 533 PVATDFE 539
PV T E
Sbjct: 3194 PVTTSTE 3200
Score = 31.2 bits (69), Expect = 4.6
Identities = 45/236 (19%), Positives = 70/236 (29%), Gaps = 20/236 (8%)
Query: 307 PGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVP 366
P + S F P + + ST S P+ + E+ G +P
Sbjct: 2215 PSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTS----IP 2270
Query: 367 VYTDSE---PRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQ 423
T SE P +P+ EV T + P + E P G
Sbjct: 2271 TSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTS--- 2327
Query: 424 EVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQ 483
+P T SE + P +P+ T E + + P+ T ++
Sbjct: 2328 -MPTSTSSE---------GNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGS 2377
Query: 484 EVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFE 539
D G VP+ T P+ E S + ++ PV T E
Sbjct: 2378 SPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTE 2433
Score = 30.4 bits (67), Expect = 7.8
Identities = 46/242 (19%), Positives = 81/242 (33%), Gaps = 27/242 (11%)
Query: 323 TLDKQVISTSSDAESREEVPMCSDAESR---QEVPMCTGPESRREV------PVYTDSEP 373
T + S+ + AE +P + +E + + +P+ P + E PV ++S
Sbjct: 1428 TTSAEATSSPTTAEGIS-IPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPV 1486
Query: 374 RQEVPMCSDPEPRQEVPTCT-----GPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMY 428
+ S P P + G + +P+ + E+ + A P+
Sbjct: 1487 VTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVT 1546
Query: 429 TDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYT--------GPESRQEVPMYTGPE 480
T S+ P D Q GS P +P+ T S + T
Sbjct: 1547 TYSQASSS-PTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVT 1605
Query: 481 SRQEVLIRTDPESRQEIMCTGHESKQ---EVPICTDPISKQEDSMCTHAEINQKLPVATD 537
+ E T E + T E +P+ T P++ E S + ++ PV T
Sbjct: 1606 ASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITS 1665
Query: 538 FE 539
E
Sbjct: 1666 TE 1667
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,606,799
Number of Sequences: 37866
Number of extensions: 1937980
Number of successful extensions: 6185
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 5522
Number of HSP's gapped (non-prelim): 458
length of query: 910
length of database: 18,247,518
effective HSP length: 111
effective length of query: 799
effective length of database: 14,044,392
effective search space: 11221469208
effective search space used: 11221469208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.