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Search of human proteins with 24308326
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
(778 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 1587 0.0
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 1061 0.0
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 296 6e-80
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 295 8e-80
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 295 1e-79
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 295 1e-79
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 293 3e-79
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 293 3e-79
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 292 9e-79
gi|116256471 SNF1-like kinase [Homo sapiens] 290 3e-78
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 289 6e-78
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 288 1e-77
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 286 4e-77
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 286 4e-77
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 286 4e-77
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 283 4e-76
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 276 5e-74
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 275 2e-73
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 266 5e-71
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 234 2e-61
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 233 7e-61
gi|156105707 SNF related kinase [Homo sapiens] 224 2e-58
gi|156105705 SNF related kinase [Homo sapiens] 224 2e-58
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 221 3e-57
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 200 4e-51
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 193 4e-49
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 189 6e-48
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 189 6e-48
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 189 6e-48
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 189 6e-48
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 1587 bits (4108), Expect = 0.0
Identities = 778/778 (100%), Positives = 778/778 (100%)
Query: 1 MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV 60
MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV
Sbjct: 1 MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV 60
Query: 61 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 120
AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD
Sbjct: 61 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 120
Query: 121 YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL 180
YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL
Sbjct: 121 YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL 180
Query: 181 QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL 240
QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL
Sbjct: 181 QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL 240
Query: 241 EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300
EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP
Sbjct: 241 EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300
Query: 301 GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER 360
GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER
Sbjct: 301 GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER 360
Query: 361 YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA 420
YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA
Sbjct: 361 YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA 420
Query: 421 LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS
Sbjct: 421 LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
Query: 481 RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP 540
RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP
Sbjct: 481 RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP 540
Query: 541 GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI 600
GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI
Sbjct: 541 GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI 600
Query: 601 SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP 660
SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP
Sbjct: 601 SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP 660
Query: 661 VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP 720
VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP
Sbjct: 661 VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP 720
Query: 721 SVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP 778
SVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP
Sbjct: 721 SVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP 778
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 1061 bits (2745), Expect = 0.0
Identities = 548/730 (75%), Positives = 603/730 (82%), Gaps = 80/730 (10%)
Query: 1 MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV 60
M+S K+GG QHAQYVGPYRLEKTLGKGQTGLVKLGVHC+T QKV
Sbjct: 1 MTSTGKDGGA---------------QHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKV 45
Query: 61 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 120
AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD
Sbjct: 46 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 105
Query: 121 YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL 180
YLVKKGRLTPKEARKFFRQI+SALDFCHS+SICHRDLKPENLLLDEKNNIRIADFGMASL
Sbjct: 106 YLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASL 165
Query: 181 QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL 240
QVGDSLLETSCGSPHYACPEVI+GEKYDGR+AD+WSCGVILFALLVGALPFDDDNLRQLL
Sbjct: 166 QVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLL 225
Query: 241 EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300
EKVKRGVFHMPHFIPPDCQSLLRGMIEV+ +RL+LE IQKH WY+GGK+EP+P +P P
Sbjct: 226 EKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEP-EQPIP 284
Query: 301 GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER 360
R+V +RSLPS ++DPDVL+SM SLGCFRDR +L ++L SEEENQEKMIY+LLLDRKER
Sbjct: 285 -RKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKER 343
Query: 361 YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA 420
YPS ED+DLPPRN++DPPRKRVDSPML+RHGKRRPERKSMEVLS+TD GGSPVP RRA
Sbjct: 344 YPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD---GGSPVPARRA 400
Query: 421 LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
+EMAQH QRSRS+SGAS+GLS+SPLSSPR +P P
Sbjct: 401 IEMAQHGQRSRSISGASSGLSTSPLSSPR-----VTPHP--------------------- 434
Query: 481 RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP 540
S R +PLP P G+P +HTP+ SP GTP TPP SP
Sbjct: 435 ---------------SPRGSPLPTPKGTP-----------VHTPKESPAGTPNPTPPSSP 468
Query: 541 GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI 600
VGG WR+RLNSI+NSFLGSPRFHRRK+QVPT EEMS+LTPESSPELAK+SWFGNFI
Sbjct: 469 --SVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFI 526
Query: 601 SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP 660
SL+KEEQIF+V+KDKPLSSIKADIVHAFLSIPSLSHSV+SQTSFRAEYKA+GGP+VFQKP
Sbjct: 527 SLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKP 586
Query: 661 VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP 720
V+FQVDI+ +EG E GIYSVTFTL+SGPSRRFKRVVETIQAQLLSTHD P
Sbjct: 587 VKFQVDITYTEGGEAQKE------NGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPP 640
Query: 721 SVQALADEKN 730
+ Q L+D N
Sbjct: 641 AAQHLSDTTN 650
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 296 bits (757), Expect = 6e-80
Identities = 204/574 (35%), Positives = 290/574 (50%), Gaps = 48/574 (8%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 49 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
Query: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
Query: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE-MAQHSQRSRSVSGASTG-LSSSP 444
H +R + + +D G P + + + +++ R +G +SS
Sbjct: 392 --SHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASST 449
Query: 445 LSSPRSPVFSF-----SPEPGAG-----DEARGGGSPTSKTQTLPSRGPRGGGAGEQP-- 492
P SP+ +P P R SP + +L + G P
Sbjct: 450 AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQR 509
Query: 493 ---PPPSARS-TPLPGPPGSPRSSGGTPLHSPLHTPR----ASPTGTPGTTPPPSPGGGV 544
PSA + + G P G S H + P P SP G
Sbjct: 510 VPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHS 569
Query: 545 GGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEE 578
G R SI + F + +F RR + P +++
Sbjct: 570 QGR--RGASGSIFSKF--TSKFVRRNLNEPESKD 599
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 295 bits (756), Expect = 8e-80
Identities = 205/566 (36%), Positives = 286/566 (50%), Gaps = 76/566 (13%)
Query: 25 PQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAI 84
P+ +VG YRL +T+GKG VKL H +TG++VAIKI+++ +L+ S L K+ RE+ I
Sbjct: 50 PEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRI 109
Query: 85 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSAL 144
+K + HP+++KL +V E +K LYLV+E+ S GE+FDYLV GR+ KEAR FRQIVSA+
Sbjct: 110 MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169
Query: 145 DFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKG 204
+CH +I HRDLK ENLLLD + NI+IADFG ++ S L+T CGSP YA PE+ +G
Sbjct: 170 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 229
Query: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 264
+KYDG D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC+S+LR
Sbjct: 230 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRR 289
Query: 265 MIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMA 324
+ + P KR +LEQI K W G G + + P D +E M
Sbjct: 290 FLVLNPAKRCTLEQIMKDKWINIGYE----------GEELKPYTEPEEDFGDTKRIEVMV 339
Query: 325 SLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDS 384
+G RE + L S++ N E YLLL RK ++ R RV +
Sbjct: 340 GMG--YTREEIKESLTSQKYN-EVTATYLLLGRK-------TEEGGDRGAPGLALARVRA 389
Query: 385 PMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSP 444
P + +G T + G S +R+ H QR S G S +P
Sbjct: 390 PSDTTNG--------------TSSSKGTSHSKGQRSSSSTYHRQRRHS---DFCGPSPAP 432
Query: 445 LSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPG 504
L RSP + G K + LP R AG +R
Sbjct: 433 LHPKRSPTST--------------GEAELKEERLPGRKASCSTAGS-----GSRGL---- 469
Query: 505 PPGSPR-SSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGS 563
PP SP SS P + + R T TP PP + + RN+++ +
Sbjct: 470 PPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPP--------------SMMTRRNTYVCT 515
Query: 564 PR-FHRRKMQVPTAEEMSSLTPESSP 588
R R +P +E SS TP P
Sbjct: 516 ERPGAERPSLLPNGKENSSGTPRVPP 541
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 295 bits (754), Expect = 1e-79
Identities = 191/506 (37%), Positives = 272/506 (53%), Gaps = 44/506 (8%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 49 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
Query: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
Query: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE-MAQHSQRSRSVSGASTGLSSSPL 445
H +R + + +D G P + + + +++ R +G +S
Sbjct: 392 --SHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-- 447
Query: 446 SSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPL--P 503
S+ + P SP PG R +PT T ++ S +R++PL
Sbjct: 448 STAKVPA---SPLPGL---ERKKTTPTPSTNSVLSTSTN-----------RSRNSPLLER 490
Query: 504 GPPGSPRSSGGTPLHSPLHTPRASPT 529
G G +P P ASP+
Sbjct: 491 ASLGQASIQNGKDSTAPQRVPVASPS 516
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 295 bits (754), Expect = 1e-79
Identities = 192/508 (37%), Positives = 274/508 (53%), Gaps = 47/508 (9%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 49 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
Query: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
Query: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE---MAQHSQRSRSVSGASTGLSSS 443
H +R + + +D G + +PT + + +++ R +G +S
Sbjct: 392 --SHKVQRSVSANPKQRRFSDQAAGPA-IPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 448
Query: 444 PLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPL- 502
S+ + P SP PG R +PT T ++ S +R++PL
Sbjct: 449 --STAKVPA---SPLPGL---ERKKTTPTPSTNSVLSTSTN-----------RSRNSPLL 489
Query: 503 -PGPPGSPRSSGGTPLHSPLHTPRASPT 529
G G +P P ASP+
Sbjct: 490 ERASLGQASIQNGKDSTAPQRVPVASPS 517
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 293 bits (751), Expect = 3e-79
Identities = 182/457 (39%), Positives = 259/457 (56%), Gaps = 34/457 (7%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 49 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 108
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 289 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 335
Query: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 336 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 391
Query: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE---MAQHSQRSRSVSGASTGLSSS 443
H +R + + +D G + +PT + + +++ R +G +S
Sbjct: 392 --SHKVQRSVSANPKQRRFSDQAAGPA-IPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 448
Query: 444 PLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
S+ + P SP PG R +PT T ++ S
Sbjct: 449 --STAKVPA---SPLPGL---ERKKTTPTPSTNSVLS 477
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 293 bits (751), Expect = 3e-79
Identities = 181/455 (39%), Positives = 257/455 (56%), Gaps = 31/455 (6%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++
Sbjct: 16 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 75
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 76 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 135
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 136 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326
P KR +LEQI K W G HE D P +EP P + DP E M S+
Sbjct: 256 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 302
Query: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386
G RE + L + N E M YLLL K + L PR D SP
Sbjct: 303 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 358
Query: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE-MAQHSQRSRSVSGASTGLSSSPL 445
H +R + + +D G P + + + +++ R +G +S
Sbjct: 359 --SHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-- 414
Query: 446 SSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
S+ + P SP PG R +PT T ++ S
Sbjct: 415 STAKVPA---SPLPGL---ERKKTTPTPSTNSVLS 443
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 292 bits (747), Expect = 9e-79
Identities = 149/340 (43%), Positives = 220/340 (64%), Gaps = 4/340 (1%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90
+G Y +++T+GKG +VK H +T KVAIKI+++ +L E L K+ RE+ I+K++ H
Sbjct: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
Query: 91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
PH+++L+ V E ++ +YLV E+ SGGE+FD+LV GR+ KEAR+ F+QIV+A+ FCH
Sbjct: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
Query: 151 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 210
+I HRDLK ENLLLD NI+IADFG ++L LL+T CGSP YA PE+ +G++YDG
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
Query: 211 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
+ D+WS GV+L+ L+ GALPFD L+ L +V G F +P F+ +C+ L+R M+ ++P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
Query: 271 EKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFR 330
KRLS+EQI KH W G + DP + ++ L+ DVL +M +G
Sbjct: 245 NKRLSMEQICKHKWMKLG--DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL-- 300
Query: 331 DRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLP 370
D+E+ + LRS+ + IY LL DR +R+ + LP
Sbjct: 301 DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP 340
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 290 bits (743), Expect = 3e-78
Identities = 202/561 (36%), Positives = 281/561 (50%), Gaps = 67/561 (11%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90
VG Y +E+TLGKG +VKL H +T +VAIKI+++ +L S L K+ RE+ ++KL+ H
Sbjct: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
Query: 91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
PH++KL+ V E K LY+V E GE+FDYL G L+ EARK F QI+SA+++CH +
Sbjct: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
Query: 151 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 210
I HRDLK ENLLLD +I++ADFG + L T CGSP YA PEV +G++Y+G
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
Query: 211 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
+ D+WS GV+L+ L+ G+LPFD NL L ++V G F +P F+ DC+SL+R M+ V+P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
Query: 271 EKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSN-GELDPDVLESMASLGCF 329
+R+++ QI++H W +PCL + S SN G+ D L M +LG
Sbjct: 264 ARRITIAQIRQHRWM-----RAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV- 317
Query: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSR 389
DR+R L++ N IYYLLL+R + Y + + P
Sbjct: 318 -DRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGP------------------ 358
Query: 390 HGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTG--LSSS---- 443
R+P +S ++ + G S P R AL Q +SV A L SS
Sbjct: 359 --ARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWP 416
Query: 444 ---PLSSPRSPVFSFSP-------EPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPP 493
P+ + S VF P + +EAR G + T S P G
Sbjct: 417 LFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESL-PSSTGRRHTLA 475
Query: 494 PPSARSTPLPGP-----------PGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGG 542
S R +PL P P SS S +P A +GTP T
Sbjct: 476 EVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSP-AGLSGTPATQ------- 527
Query: 543 GVGGAAWRSRLNSIRNSFLGS 563
G+ GA RL S FLGS
Sbjct: 528 GLLGACSPVRLAS---PFLGS 545
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 289 bits (740), Expect = 6e-78
Identities = 154/343 (44%), Positives = 215/343 (62%), Gaps = 11/343 (3%)
Query: 25 PQHAQY----VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVER 80
P+H Q VG Y +E TLGKG +VKLG H IT +VAIKI+++ +L L K+ R
Sbjct: 7 PRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYR 66
Query: 81 EIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQI 140
E+ I+K+++HPH++KL+ V E K LYLV E+ GE+FDYL GRL EAR+ F QI
Sbjct: 67 EVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQI 126
Query: 141 VSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPE 200
+SA+D+CH I HRDLK ENLLLD NI+IADFG + LL T CGSP YA PE
Sbjct: 127 LSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPE 186
Query: 201 VIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 260
V +G++Y+G + D+WS GV+L+ L+ GALPFD L L ++V G F +P+F+ DC+
Sbjct: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEH 246
Query: 261 LLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVL 320
L+R M+ ++P KRL++ QI++H W L P L P + PS GE + VL
Sbjct: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQ-----EQENEPSIGEFNEQVL 301
Query: 321 ESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPS 363
M SLG D+++ L+++ N IY+LL++R + + S
Sbjct: 302 RLMHSLGI--DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS 342
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 288 bits (737), Expect = 1e-77
Identities = 203/579 (35%), Positives = 300/579 (51%), Gaps = 62/579 (10%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++
Sbjct: 52 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G+KYDG
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELD-PDVLESMAS 325
P KR +LEQI K W G HE D P +EP ELD D
Sbjct: 292 PIKRGTLEQIMKDRWINAG-HEEDELKPFVEP---------------ELDISDQKRIDIM 335
Query: 326 LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVD-----PPRK 380
+G +E + L S+ + E YLLL RK ++ P +D++ P
Sbjct: 336 VGMGYSQEEIQESL-SKMKYDEITATYLLLGRK-------SSEVRPSSDLNNSTGQSPHH 387
Query: 381 RVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGL 440
+V + S +RR + + A S T + ++ + SR SG++ G
Sbjct: 388 KVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSRKSSGSAVGG 446
Query: 441 SSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARST 500
+P SP+ + P D K+ T+PS GG + R+T
Sbjct: 447 KG---IAPASPMLGNASNPNKADIPE-----RKKSSTVPSSNTASGGM-------TRRNT 491
Query: 501 PLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRL-----NS 555
+ S R++ HS + + + T P P + + AA R+ +
Sbjct: 492 YV----CSERTTADR--HSVIQNGKENST-IPDQRTPVASTHSISSAATPDRIRFPRGTA 544
Query: 556 IRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRS 594
R++F G PR RR SL+ E++P RS
Sbjct: 545 SRSTFHGQPR-ERRTATYNGPPASPSLSHEATPLSQTRS 582
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 286 bits (733), Expect = 4e-77
Identities = 204/588 (34%), Positives = 300/588 (51%), Gaps = 64/588 (10%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++
Sbjct: 52 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G+KYDG
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELD-PDVLESMAS 325
P KR +LEQI K W G HE D P +EP ELD D
Sbjct: 292 PIKRGTLEQIMKDRWINAG-HEEDELKPFVEP---------------ELDISDQKRIDIM 335
Query: 326 LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQD---------LPPRNDVD 376
+G +E + L S+ + E YLLL RK D + P +D++
Sbjct: 336 VGMGYSQEEIQESL-SKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLN 394
Query: 377 -----PPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSR 431
P +V + S +RR + + A S T + ++ + SR
Sbjct: 395 NSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSR 453
Query: 432 SVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQ 491
SG++ G +P SP+ + P D K+ T+PS GG
Sbjct: 454 KSSGSAVGGKG---IAPASPMLGNASNPNKADIPE-----RKKSSTVPSSNTASGGM--- 502
Query: 492 PPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRS 551
+ R+T + S R++ HS + + + T P P + + AA
Sbjct: 503 ----TRRNTYV----CSERTTADR--HSVIQNGKENST-IPDQRTPVASTHSISSAATPD 551
Query: 552 RL-----NSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRS 594
R+ + R++F G PR RR SL+ E++P RS
Sbjct: 552 RIRFPRGTASRSTFHGQPR-ERRTATYNGPPASPSLSHEATPLSQTRS 598
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 286 bits (733), Expect = 4e-77
Identities = 204/588 (34%), Positives = 300/588 (51%), Gaps = 64/588 (10%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++
Sbjct: 52 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G+KYDG
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELD-PDVLESMAS 325
P KR +LEQI K W G HE D P +EP ELD D
Sbjct: 292 PIKRGTLEQIMKDRWINAG-HEEDELKPFVEP---------------ELDISDQKRIDIM 335
Query: 326 LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQD---------LPPRNDVD 376
+G +E + L S+ + E YLLL RK D + P +D++
Sbjct: 336 VGMGYSQEEIQESL-SKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLN 394
Query: 377 -----PPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSR 431
P +V + S +RR + + A S T + ++ + SR
Sbjct: 395 NSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSR 453
Query: 432 SVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQ 491
SG++ G +P SP+ + P D K+ T+PS GG
Sbjct: 454 KSSGSAVGGKG---IAPASPMLGNASNPNKADIPE-----RKKSSTVPSSNTASGGM--- 502
Query: 492 PPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRS 551
+ R+T + S R++ HS + + + T P P + + AA
Sbjct: 503 ----TRRNTYV----CSERTTADR--HSVIQNGKENST-IPDQRTPVASTHSISSAATPD 551
Query: 552 RL-----NSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRS 594
R+ + R++F G PR RR SL+ E++P RS
Sbjct: 552 RIRFPRGTASRSTFHGQPR-ERRTATYNGPPASPSLSHEATPLSQTRS 598
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 286 bits (733), Expect = 4e-77
Identities = 204/588 (34%), Positives = 300/588 (51%), Gaps = 64/588 (10%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL KT+GKG VKL H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++
Sbjct: 52 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G+KYDG
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ + +
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELD-PDVLESMAS 325
P KR +LEQI K W G HE D P +EP ELD D
Sbjct: 292 PIKRGTLEQIMKDRWINAG-HEEDELKPFVEP---------------ELDISDQKRIDIM 335
Query: 326 LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQD---------LPPRNDVD 376
+G +E + L S+ + E YLLL RK D + P +D++
Sbjct: 336 VGMGYSQEEIQESL-SKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLN 394
Query: 377 -----PPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSR 431
P +V + S +RR + + A S T + ++ + SR
Sbjct: 395 NSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSR 453
Query: 432 SVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQ 491
SG++ G +P SP+ + P D K+ T+PS GG
Sbjct: 454 KSSGSAVGGKG---IAPASPMLGNASNPNKADIPE-----RKKSSTVPSSNTASGGM--- 502
Query: 492 PPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRS 551
+ R+T + S R++ HS + + + T P P + + AA
Sbjct: 503 ----TRRNTYV----CSERTTADR--HSVIQNGKENST-IPDQRTPVASTHSISSAATPD 551
Query: 552 RL-----NSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRS 594
R+ + R++F G PR RR SL+ E++P RS
Sbjct: 552 RIRFPRGTASRSTFHGQPR-ERRTATYNGPPASPSLSHEATPLSQTRS 598
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 283 bits (724), Expect = 4e-76
Identities = 149/331 (45%), Positives = 213/331 (64%), Gaps = 17/331 (5%)
Query: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
++G YRL+KT+GKG VKL H +TG++VA+KI+++ +L+ + L K+ RE+ I+K++
Sbjct: 56 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 115
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQIVSA+ +CH
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ ++ +
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPD--PCLEPAPGRRVAMRSLPSNGELDPDVLESMASLG 327
P KR SLEQI K W G E + P EP P D ++ M ++G
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFN------------DTKRIDIMVTMG 343
Query: 328 CFRDRERLHRELRSEEENQEKMIYYLLLDRK 358
RD + ++ E M Y+LL RK
Sbjct: 344 FARDE---INDALINQKYDEVMATYILLGRK 371
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 276 bits (706), Expect = 5e-74
Identities = 150/367 (40%), Positives = 221/367 (60%), Gaps = 16/367 (4%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89
+G Y L TLG G G VK+G H +TG KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HPH++KL+ V +++V+E+VSGGELFDY+ K GRL KE+R+ F+QI+S +D+CH
Sbjct: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 143
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
+ + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G
Sbjct: 144 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++ P SLL+ M++V+
Sbjct: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329
P KR +++ I++H W+ K + L P S+ +D + L+ +
Sbjct: 264 PMKRATIKDIREHEWF---KQDLPKYLFPEDPSY-------SSTMIDDEALKEVCEKFEC 313
Query: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSR 389
+ E L ++ + Y+L++D + +D L PP +D L+R
Sbjct: 314 SEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA----TSPPDSFLDDHHLTR 369
Query: 390 -HGKRRP 395
H +R P
Sbjct: 370 PHPERVP 376
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 275 bits (702), Expect = 2e-73
Identities = 150/369 (40%), Positives = 220/369 (59%), Gaps = 14/369 (3%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89
+G Y L TLG G G VK+G H +TG KVA+KI+NR+K+ S V+ K++REI LKL
Sbjct: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
HPH++KL+ V ++V+E+VSGGELFDY+ K GR+ EAR+ F+QI+SA+D+CH
Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132
Query: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
+ + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G
Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WSCGVIL+ALL G LPFDD+++ L +K++ GVF++P ++ +LL M++V+
Sbjct: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329
P KR +++ I++H W+ K + L P S +N D V E C
Sbjct: 253 PLKRATIKDIREHEWF---KQDLPSYLFPED------PSYDANVIDDEAVKEVCEKFEC- 302
Query: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDL---PPRNDVDPPRKRVDSPM 386
+ E ++ + ++Q + Y+L++D + + L PP P
Sbjct: 303 TESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPG 362
Query: 387 LSRHGKRRP 395
L H +R P
Sbjct: 363 LKPHPERMP 371
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 266 bits (680), Expect = 5e-71
Identities = 150/382 (39%), Positives = 221/382 (57%), Gaps = 31/382 (8%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89
+G Y L TLG G G VK+G H +TG KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
Query: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR---------------LTPKEAR 134
HPH++KL+ V +++V+E+VSGGELFDY+ K GR L KE+R
Sbjct: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESR 143
Query: 135 KFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSP 194
+ F+QI+S +D+CH + + HRDLKPEN+LLD N +IADFG++++ L TSCGSP
Sbjct: 144 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 203
Query: 195 HYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI 254
+YA PEVI G Y G D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++
Sbjct: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263
Query: 255 PPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGE 314
P SLL+ M++V+P KR +++ I++H W+ K + L P S+
Sbjct: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWF---KQDLPKYLFPEDPSY-------SSTM 313
Query: 315 LDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRND 374
+D + L+ + + E L ++ + Y+L++D + +D L
Sbjct: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA---- 369
Query: 375 VDPPRKRVDSPMLSR-HGKRRP 395
PP +D L+R H +R P
Sbjct: 370 TSPPDSFLDDHHLTRPHPERVP 391
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 234 bits (597), Expect = 2e-61
Identities = 114/261 (43%), Positives = 172/261 (65%), Gaps = 3/261 (1%)
Query: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 93
Y L +T+G G VKL H +TG+ VAIKI+++ L S L +++ EI LK + H H+
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
Query: 94 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSIC 153
+L+ V E +++VLE+ GGELFDY++ + RL+ +E R FRQIVSA+ + HS
Sbjct: 70 CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
Query: 154 HRDLKPENLLLDEKNNIRIADFGMASLQVG--DSLLETSCGSPHYACPEVIKGEKYDGRR 211
HRDLKPENLL DE + +++ DFG+ + G D L+T CGS YA PE+I+G+ Y G
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE 189
Query: 212 ADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPE 271
AD+WS G++L+ L+ G LPFDDDN+ L +K+ RG + +P ++ P LL+ M++V+P+
Sbjct: 190 ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK 249
Query: 272 KRLSLEQIQKHPWYLGGKHEP 292
KR+S++ + HPW + + P
Sbjct: 250 KRISMKNLLNHPWIMQDYNYP 270
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 233 bits (593), Expect = 7e-61
Identities = 110/267 (41%), Positives = 171/267 (64%), Gaps = 7/267 (2%)
Query: 19 HPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLS-ESVLMK 77
H H H +H Y L++TLGKG G VK +G+ VAIK + ++K+ E ++
Sbjct: 45 HHHKHNLKHR-----YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVH 99
Query: 78 VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF 137
+ REI I+ + HPH++ +++V+ENK + +++E+ S GEL+DY+ ++ RL+ +E R FF
Sbjct: 100 IRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFF 159
Query: 138 RQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYA 197
RQIVSA+ +CH + HRDLK EN+LLD+ NI+IADFG+++L D L+T CGSP YA
Sbjct: 160 RQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYA 219
Query: 198 CPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD 257
PE++ G Y G D W+ GV+L+ L+ G +PFD + + L+ ++ G + P P D
Sbjct: 220 SPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSD 278
Query: 258 CQSLLRGMIEVEPEKRLSLEQIQKHPW 284
+ L+R M+ V P++R ++E I H W
Sbjct: 279 ARGLIRWMLMVNPDRRATIEDIANHWW 305
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 224 bits (572), Expect = 2e-58
Identities = 117/328 (35%), Positives = 191/328 (58%), Gaps = 8/328 (2%)
Query: 32 GPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 91
G Y L+KTLG+G +VKL H TG+KVA+K++++ KL + +E+ +KL++HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 92 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIVSALDFCHSY 150
++++L++V + + LYL+LE GG++FDY++K L A+K+F QIV A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 151 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329
P++R SLE+I+ HPW G DP PA + + S + E + + + LG
Sbjct: 254 PKRRASLEEIENHPWLQG----VDP--SPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307
Query: 330 RDRERLHRELRSEEENQEKMIYYLLLDR 357
DR+ + L + N Y+LL +R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAER 335
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 224 bits (572), Expect = 2e-58
Identities = 117/328 (35%), Positives = 191/328 (58%), Gaps = 8/328 (2%)
Query: 32 GPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 91
G Y L+KTLG+G +VKL H TG+KVA+K++++ KL + +E+ +KL++HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 92 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIVSALDFCHSY 150
++++L++V + + LYL+LE GG++FDY++K L A+K+F QIV A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 151 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329
P++R SLE+I+ HPW G DP PA + + S + E + + + LG
Sbjct: 254 PKRRASLEEIENHPWLQG----VDP--SPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307
Query: 330 RDRERLHRELRSEEENQEKMIYYLLLDR 357
DR+ + L + N Y+LL +R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAER 335
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 221 bits (562), Expect = 3e-57
Identities = 110/267 (41%), Positives = 167/267 (62%), Gaps = 8/267 (2%)
Query: 19 HPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLS-ESVLMK 77
H H H +H Y +TLGKG G VK +G+ VAIK + ++K+ E LM
Sbjct: 43 HHHKHNLRHR-----YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMH 96
Query: 78 VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF 137
+ REI I+ + HPH++ +H+V+EN + +V+E+ S G+L+DY+ ++ +L+ +EAR FF
Sbjct: 97 IRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFF 156
Query: 138 RQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYA 197
RQIVSA+ +CH + HRDLK EN+LLD NI+IADFG+++L L+T CGSP YA
Sbjct: 157 RQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYA 216
Query: 198 CPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD 257
PE++ G+ Y G D WS GV+L+ L+ G +PFD + + L++++ G + P P D
Sbjct: 217 SPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP-KPSD 275
Query: 258 CQSLLRGMIEVEPEKRLSLEQIQKHPW 284
L+R ++ V P +R +LE + H W
Sbjct: 276 ACGLIRWLLMVNPTRRATLEDVASHWW 302
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 200 bits (509), Expect = 4e-51
Identities = 108/337 (32%), Positives = 185/337 (54%), Gaps = 8/337 (2%)
Query: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90
+G YR+ +G G VKLG+H +T +KVAIKI+++ KL + + REI+ ++ + H
Sbjct: 71 IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130
Query: 91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
P++++L++V E L+LV+E+ GGELF + +G+L+ E++ F QIVSA+ H
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190
Query: 151 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 210
I HRDLK EN+ +++ DFG +++ +L T CGSP YA PE+ + E Y G
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250
Query: 211 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
D+W+ GV+L+ ++ G +PF + + +L + + G + +P + C L+RG+++ P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310
Query: 271 EKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFR 330
+R ++ I W G + P P LEP + + E + +V ++ LG
Sbjct: 311 TERYGIDCIMNDEWMQGVPY-PTP-LEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITE 368
Query: 331 D--RERLHRELRSEEENQEKMIYYLLLDRKERYPSCE 365
+ R R+ RS +Y ++L R +R + E
Sbjct: 369 EHIRNNQGRDARSSITG----VYRIILHRVQRKKALE 401
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 193 bits (491), Expect = 4e-49
Identities = 175/600 (29%), Positives = 268/600 (44%), Gaps = 88/600 (14%)
Query: 26 QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSES--VLMKVEREI 82
QH + VG Y + + LG+G V+ G+H +TG+KVAIK++++++ + V + RE
Sbjct: 53 QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
Query: 83 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVS 142
I ++I HP++ +L D+ E + YLV+E GG L + +K RL EAR++ RQ++S
Sbjct: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
Query: 143 ALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 199
A++ H + HRDLK ENLLLDE NNI++ DFG+ A + T CGSP YA P
Sbjct: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
Query: 200 EVIKGEKYDGRRADMWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 256
E++ +KY G + D+WS GV ++A+L G LPF + +LR L +K V + + +P +
Sbjct: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
Query: 257 DCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGR--------RVAMRS 308
S LR ++E +P KR +++Q + W PC P R V +
Sbjct: 292 GAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHM 351
Query: 309 LPSNGELDPDVLES-MASLGC------FRDRERLHRELRSEEENQEKMIYYLLLDRKERY 361
G + DV+ + +++ C F ++L R L + + Q+ + Y L + E+Y
Sbjct: 352 TEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKY 411
Query: 362 PSCED------------------QDLPPRNDVDPPRKRVD---SPMLSRHGKRRPERKSM 400
+ ++ QD P+ KR D P + K P K
Sbjct: 412 RAPKESYEASLDTWTRDLEFHAVQDKKPKEQ----EKRGDFLHRPFSKKLDKNLPSHKQP 467
Query: 401 EVLSITDAGGGGSPVPTRRALEMAQHSQRS-------RSVSGASTGLSSS----PLSSPR 449
+T + + R+A + + + S R S ++ SSS P+ PR
Sbjct: 468 SGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPR 527
Query: 450 SPVFSFSPE---PGAG-------------DEARGGGSPTSKTQTLPSRGPRGGGAGEQPP 493
+P PE PG G D R S + + P P
Sbjct: 528 TPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFES-VDRDDHVEVLSPSHHYRILNSP 586
Query: 494 PPSAR-----STPLPGPPGSPRSSGGTPLHSPL----HTPRASPTGTPG-TTPPPSPGGG 543
AR T PG P S TPLH L H + SP G PPP P G
Sbjct: 587 VSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNG 646
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 189 bits (481), Expect = 6e-48
Identities = 100/264 (37%), Positives = 160/264 (60%), Gaps = 9/264 (3%)
Query: 29 QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLI 88
++ Y+L + LGKG +V+ + TGQ+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 149 SYSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIKG 204
I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV++
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 260
+ Y G+ DMW+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
L+ M+ + P KR++ + KHPW
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 189 bits (481), Expect = 6e-48
Identities = 100/264 (37%), Positives = 160/264 (60%), Gaps = 9/264 (3%)
Query: 29 QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLI 88
++ Y+L + LGKG +V+ + TGQ+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 149 SYSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIKG 204
I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV++
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 260
+ Y G+ DMW+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
L+ M+ + P KR++ + KHPW
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 189 bits (481), Expect = 6e-48
Identities = 100/264 (37%), Positives = 160/264 (60%), Gaps = 9/264 (3%)
Query: 29 QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLI 88
++ Y+L + LGKG +V+ + TGQ+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 149 SYSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIKG 204
I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV++
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 260
+ Y G+ DMW+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
L+ M+ + P KR++ + KHPW
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 189 bits (481), Expect = 6e-48
Identities = 100/264 (37%), Positives = 160/264 (60%), Gaps = 9/264 (3%)
Query: 29 QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLI 88
++ Y+L + LGKG +V+ + TGQ+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 89 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 148
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 149 SYSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIKG 204
I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV++
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 260
+ Y G+ DMW+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 261 LLRGMIEVEPEKRLSLEQIQKHPW 284
L+ M+ + P KR++ + KHPW
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,046,113
Number of Sequences: 37866
Number of extensions: 2621115
Number of successful extensions: 30752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1019
Number of HSP's successfully gapped in prelim test: 1736
Number of HSP's that attempted gapping in prelim test: 14259
Number of HSP's gapped (non-prelim): 12300
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.