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Search of human proteins with 24308229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308229 protein kinase C and casein kinase substrate in
neurons 1 [Homo sapiens]
(444 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308229 protein kinase C and casein kinase substrate in neur... 915 0.0
gi|148747351 protein kinase C and casein kinase substrate in neu... 632 0.0
gi|19224660 protein kinase C and casein kinase substrate in neur... 477 e-135
gi|20149528 proline-serine-threonine phosphatase interacting pro... 94 2e-19
gi|165905601 proline-serine-threonine phosphatase interacting pr... 65 2e-10
gi|226371723 FCH domain only 2 isoform a [Homo sapiens] 62 8e-10
gi|20357552 cortactin isoform a [Homo sapiens] 62 1e-09
gi|20357556 cortactin isoform b [Homo sapiens] 62 1e-09
gi|27544941 myosin IF [Homo sapiens] 59 9e-09
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 57 3e-08
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 57 3e-08
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 57 3e-08
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 56 6e-08
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 56 8e-08
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 55 1e-07
gi|38524622 formin binding protein 1 [Homo sapiens] 55 1e-07
gi|226371725 FCH domain only 2 isoform b [Homo sapiens] 55 1e-07
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 55 1e-07
gi|115527120 nebulin [Homo sapiens] 54 2e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 53 6e-07
gi|11321634 CD2-associated protein [Homo sapiens] 52 8e-07
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 52 8e-07
gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo... 52 8e-07
gi|55956916 myosin IE [Homo sapiens] 52 8e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 52 1e-06
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 51 2e-06
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] 51 2e-06
gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] 51 2e-06
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 51 2e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 51 2e-06
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 915 bits (2365), Expect = 0.0
Identities = 444/444 (100%), Positives = 444/444 (100%)
Query: 1 MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL 60
MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL
Sbjct: 1 MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL 60
Query: 61 TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA 120
TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA
Sbjct: 61 TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA 120
Query: 121 YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE 180
YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE
Sbjct: 121 YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE 180
Query: 181 QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK 240
QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK
Sbjct: 181 QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK 240
Query: 241 RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP 300
RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP
Sbjct: 241 RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP 300
Query: 301 QFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEW 360
QFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEW
Sbjct: 301 QFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEW 360
Query: 361 SDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDE 420
SDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDE
Sbjct: 361 SDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDE 420
Query: 421 QGWCRGRLDSGQLGLYPANYVEAI 444
QGWCRGRLDSGQLGLYPANYVEAI
Sbjct: 421 QGWCRGRLDSGQLGLYPANYVEAI 444
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 632 bits (1631), Expect = 0.0
Identities = 311/487 (63%), Positives = 383/487 (78%), Gaps = 45/487 (9%)
Query: 1 MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL 60
MS +YD+ S+ E ++DSFWEVGNYKRTVKRIDDGHRLC+DLMNC+ ERA+IEKAY QQL
Sbjct: 1 MSVTYDD-SVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQL 59
Query: 61 TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA 120
T+WA+RWRQL+EKGPQYG++E+AW A M+EA++VSELH EVK +L+N+D EK+KNWQK+A
Sbjct: 60 TEWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEA 119
Query: 121 YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE 180
+HKQ+MGGFKETKEAEDGFRKAQKPWAKK+KE+EAAKKA+H ACKEEKLA++RE NSK +
Sbjct: 120 FHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKAD 179
Query: 181 QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK 240
S+ PEQ KKLQDK++KCKQDV KT+EKYEK L+++ + TPQYMENMEQVFEQCQQFEEK
Sbjct: 180 PSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEK 239
Query: 241 RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP 300
RL F +EVLL++++HL+L+ + Y +Y +LEQ+IR ADA EDLRWFR+ GPGM MNWP
Sbjct: 240 RLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWP 299
Query: 301 QFEEWNPDLPHTTTKKEKQPKKAEGVALT--NATG------------------AVESTSQ 340
QFEEW+ DL T +++EK+ K +GV LT N TG A + SQ
Sbjct: 300 QFEEWSADLNRTLSRREKK-KATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQ 358
Query: 341 AG--------DRGS------------VSSYDRGQPYATEWSDDESGNPFGGSETNGGANP 380
+ D GS VSSY++ Q Y T+WSDDES NPF ++ NG +NP
Sbjct: 359 SSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNP 418
Query: 381 FEDDSKG---VRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYP 437
F+DD+ VRVRALYDY+GQE DELSFKAGDELTK+ +EDEQGWC+GRLD+GQ+GLYP
Sbjct: 419 FDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYP 478
Query: 438 ANYVEAI 444
ANYVEAI
Sbjct: 479 ANYVEAI 485
>gi|19224660 protein kinase C and casein kinase substrate in neurons
3 [Homo sapiens]
Length = 424
Score = 477 bits (1228), Expect = e-135
Identities = 227/441 (51%), Positives = 314/441 (71%), Gaps = 25/441 (5%)
Query: 10 LAPEETTD------SFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDW 63
+APEE SFWE GNY+RTV+R++DGHRLC DL++C QERA+IEKAY QQL DW
Sbjct: 1 MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW 60
Query: 64 AKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHK 123
A++WR +EKGPQYG+LE+AW A T A+++S LH EV+ L +D E+V+ WQ+ A+H+
Sbjct: 61 ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR 120
Query: 124 QIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSV 183
++GGF+E++ AEDGFRKAQKPW K++KE+EA+KK+YH A K+EK A TRE ++K + +V
Sbjct: 121 PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV 180
Query: 184 TPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLV 243
+ EQ +KLQ++V++C ++ +KT+ +YE+ L ++ + TP+YME+MEQ FE CQ E +RL+
Sbjct: 181 SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL 240
Query: 244 FLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFE 303
F K++LL + +HL+L+ + + ++R+L Q I A +EDLRW+RST GPGM MNWPQFE
Sbjct: 241 FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE 300
Query: 304 EWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDD 363
EW+ D T ++KEK + + V LT+ + T A S S GQ EWSD+
Sbjct: 301 EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGT--APPPQSPGSPGTGQD--EEWSDE 356
Query: 364 ESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGW 423
ES + GVRVRALYDY GQE DELSF+AG+EL K+ EEDEQGW
Sbjct: 357 ESP---------------RKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGW 401
Query: 424 CRGRLDSGQLGLYPANYVEAI 444
C+G+L SG++GLYPANYVE +
Sbjct: 402 CQGQLQSGRIGLYPANYVECV 422
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 94.4 bits (233), Expect = 2e-19
Identities = 102/447 (22%), Positives = 186/447 (41%), Gaps = 58/447 (12%)
Query: 17 DSFW-----EVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLI 71
D+FW Y+ ++R+ DG ++C D+ +++RA+ E+ YG++L A++
Sbjct: 9 DAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQT 68
Query: 72 EKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNE--DLEKVKNWQKDAYHKQIMGGF 129
E SL ++ ++ + + V H ++ L E LE+ + QK+
Sbjct: 69 E----INSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKE---------- 114
Query: 130 KETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQK 189
+ K+ E + QK K+ +KK Y C++ A + + + +Q +
Sbjct: 115 -QRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDA--EQAFERISANGHQKQVE 171
Query: 190 KLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVL 249
K Q+K +CK + + Y + + + K ++ + E Q E RL L+ L
Sbjct: 172 KSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNAL 231
Query: 250 LDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWF--RSTSGPGMPMNWPQFEEWNP 307
L++ + +Y E+ + G D+ F ++G P P ++
Sbjct: 232 WVHSNQLSM-QCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDR 290
Query: 308 DLPHTTTKKEKQP-----KKAEGVALTNATGAVESTSQAGDRGSVSSY----DRGQPYAT 358
++ T+ QP K+ G+ G+ ++TS A S + +R + T
Sbjct: 291 EVTPLTSSPGIQPSCGMIKRFSGL----LHGSPKTTSLAASAASTETLTPTPERNEGVYT 346
Query: 359 EWSDDE-SGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE 417
+ E GNP A+P ++ RALYDY Q DEL AGD L + E
Sbjct: 347 AIAVQEIQGNP---------ASPAQE------YRALYDYTAQNPDELDLSAGDILEVILE 391
Query: 418 EDEQGWCRGRLDSGQLGLYPANYVEAI 444
++ W R +GQ G P +Y+E +
Sbjct: 392 GEDGWWTVER--NGQRGFVPGSYLEKL 416
>gi|165905601 proline-serine-threonine phosphatase interacting
protein 2 [Homo sapiens]
Length = 334
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 41/277 (14%)
Query: 18 SFWEVG-----NYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIE 72
+FW Y ++ +++G + C + + ++ERA IE+ YG+ L + L
Sbjct: 9 NFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLN-------LSR 61
Query: 73 KGP----QYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGG 128
K P + +L+RA + D V++ H ++ + L E+ K++ +++ ++
Sbjct: 62 KKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQS-LREEARKMEEFREKQKLQR---- 116
Query: 129 FKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQ 188
K+T+ D K + KK + AKK Y C+++ A + S++ V P+QQ
Sbjct: 117 -KKTELIMDAIHKQKSLQFKKTMD---AKKNYEQKCRDKDEA--EQAVSRSANLVNPKQQ 170
Query: 189 KKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEV 248
+KL K+ K V+ + + Y + + K ++ + + C+ FE +
Sbjct: 171 EKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEW---QSEHIKACEAFEAQEC------ 221
Query: 249 LLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLR 285
+N N+ ++HV + +Q + + E +R
Sbjct: 222 -----ERINFFRNALWLHVNQLSQQCVTSDEMYEQVR 253
>gi|226371723 FCH domain only 2 isoform a [Homo sapiens]
Length = 810
Score = 62.4 bits (150), Expect = 8e-10
Identities = 58/285 (20%), Positives = 116/285 (40%), Gaps = 38/285 (13%)
Query: 17 DSFWEVGN--YKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKG 74
++FW N + + G +L + V+ERA IE+AY + +T AK
Sbjct: 8 ENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS----ASNY 63
Query: 75 PQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKE 134
Q G+ W T +K++ H ++ L E +K QK Y ++ + K+TKE
Sbjct: 64 SQLGTFAPVWDVFKTSTEKLANCHLDLVRKL----QELIKEVQK--YGEEQVKSHKKTKE 117
Query: 135 AEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDK 194
G +A + + L+ +K+ Y+ C E++ +++ Q +
Sbjct: 118 EVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERL---------------KKEGATQRE 162
Query: 195 VDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKR 254
++K +K + Y+ +E + + M + ++ Q EE L+ +KE++ +
Sbjct: 163 IEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSN 222
Query: 255 -----HLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPG 294
HL + + V+ E + + ++ F + G G
Sbjct: 223 AIKEIHLQIGQ------VHEEFINNMANTTVESLIQKFAESKGTG 261
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 61.6 bits (148), Expect = 1e-09
Identities = 71/265 (26%), Positives = 110/265 (41%), Gaps = 40/265 (15%)
Query: 188 QKKLQDKVDKCKQDVQKTQEKYEKVL--EDVGKTTPQYMENMEQVFEQCQQFEEKRLVFL 245
QK DK +DV + Y+K + E V T N E + ++ +Q + ++
Sbjct: 313 QKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKA--- 369
Query: 246 KEVLLDIKRHLNLA-ENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEE 304
+ +R +A E R+LE+ R ++ + P P P E
Sbjct: 370 -----EAERAQRMAKERQEQEEARRKLEEQARA----------KTQTPPVSPAPQPTEER 414
Query: 305 WNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTS-------QAGDRGSVSSYDRGQPYA 357
LP + ++ KAE + G V T +A D SS +G YA
Sbjct: 415 ----LPSSPVYEDAASFKAE----LSYRGPVSGTEPEPVYSMEAADYREASS-QQGLAYA 465
Query: 358 TEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE 417
TE + + P + + +E+D G+ ALYDY DE+SF D +T + E
Sbjct: 466 TEAVYESAEAPGHYPAEDSTYDEYENDL-GITAVALYDYQAAGDDEISFDPDDIITNI-E 523
Query: 418 EDEQGWCRGRLDSGQLGLYPANYVE 442
+ GW RG + G+ GL+PANYVE
Sbjct: 524 MIDDGWWRG-VCKGRYGLFPANYVE 547
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 61.6 bits (148), Expect = 1e-09
Identities = 71/265 (26%), Positives = 110/265 (41%), Gaps = 40/265 (15%)
Query: 188 QKKLQDKVDKCKQDVQKTQEKYEKVL--EDVGKTTPQYMENMEQVFEQCQQFEEKRLVFL 245
QK DK +DV + Y+K + E V T N E + ++ +Q + ++
Sbjct: 276 QKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKA--- 332
Query: 246 KEVLLDIKRHLNLA-ENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEE 304
+ +R +A E R+LE+ R ++ + P P P E
Sbjct: 333 -----EAERAQRMAKERQEQEEARRKLEEQARA----------KTQTPPVSPAPQPTEER 377
Query: 305 WNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTS-------QAGDRGSVSSYDRGQPYA 357
LP + ++ KAE + G V T +A D SS +G YA
Sbjct: 378 ----LPSSPVYEDAASFKAE----LSYRGPVSGTEPEPVYSMEAADYREASS-QQGLAYA 428
Query: 358 TEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE 417
TE + + P + + +E+D G+ ALYDY DE+SF D +T + E
Sbjct: 429 TEAVYESAEAPGHYPAEDSTYDEYENDL-GITAVALYDYQAAGDDEISFDPDDIITNI-E 486
Query: 418 EDEQGWCRGRLDSGQLGLYPANYVE 442
+ GW RG + G+ GL+PANYVE
Sbjct: 487 MIDDGWWRG-VCKGRYGLFPANYVE 510
>gi|27544941 myosin IF [Homo sapiens]
Length = 1098
Score = 58.9 bits (141), Expect = 9e-09
Identities = 32/58 (55%), Positives = 39/58 (67%), Gaps = 2/58 (3%)
Query: 387 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
G R RALY Y GQ+ DELSF +E+ ++ ED GW +GRL GQ GL+P NYVE I
Sbjct: 1043 GPRCRALYQYVGQDVDELSFNV-NEVIEILMEDPSGWWKGRL-HGQEGLFPGNYVEKI 1098
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 57.4 bits (137), Expect = 3e-08
Identities = 27/57 (47%), Positives = 40/57 (70%), Gaps = 2/57 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
KG + +ALYD+ G+ +DELSFKAGD +T+L D+ W G L G+ G++P NY++
Sbjct: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGEL-MGKSGIFPKNYIQ 726
Score = 46.2 bits (108), Expect = 6e-05
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
KG R A ++Y G+++DELSF G E+ L E + W RG + G+ G++P N+VE +
Sbjct: 513 KGSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEV-RGRTGIFPLNFVEPV 569
Score = 43.1 bits (100), Expect = 5e-04
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 368 PFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGR 427
P + + G+N + AL+ + + D+LSFK GD + L E + WCRGR
Sbjct: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQIL-ERLDSDWCRGR 643
Query: 428 LDSGQLGLYPANYV 441
L + G++PA +V
Sbjct: 644 LQDRE-GIFPAVFV 656
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 384 DSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEA 443
DS L+D+ ++ D+L+ +G E+ L E+ + W RG + Q+G++PANYV+
Sbjct: 435 DSGAPHAVVLHDFPAEQVDDLNLTSG-EIVYLLEKIDTDWYRGNCRN-QIGIFPANYVKV 492
Query: 444 I 444
I
Sbjct: 493 I 493
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 57.4 bits (137), Expect = 3e-08
Identities = 27/57 (47%), Positives = 40/57 (70%), Gaps = 2/57 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
KG + +ALYD+ G+ +DELSFKAGD +T+L D+ W G L G+ G++P NY++
Sbjct: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGEL-MGKSGIFPKNYIQ 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
KG R A ++Y G+++DELSF G E+ L E + W RG + G+ G++P N+VE +
Sbjct: 549 KGSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEV-RGRTGIFPLNFVEPV 605
Score = 43.1 bits (100), Expect = 5e-04
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 368 PFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGR 427
P + + G+N + AL+ + + D+LSFK GD + L E + WCRGR
Sbjct: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQIL-ERLDSDWCRGR 679
Query: 428 LDSGQLGLYPANYV 441
L + G++PA +V
Sbjct: 680 LQDRE-GIFPAVFV 692
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 384 DSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEA 443
DS L+D+ ++ D+L+ +G E+ L E+ + W RG + Q+G++PANYV+
Sbjct: 471 DSGAPHAVVLHDFPAEQVDDLNLTSG-EIVYLLEKIDTDWYRGNCRN-QIGIFPANYVKV 528
Query: 444 I 444
I
Sbjct: 529 I 529
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 57.4 bits (137), Expect = 3e-08
Identities = 27/57 (47%), Positives = 40/57 (70%), Gaps = 2/57 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
KG + +ALYD+ G+ +DELSFKAGD +T+L D+ W G L G+ G++P NY++
Sbjct: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGEL-MGKSGIFPKNYIQ 785
Score = 46.2 bits (108), Expect = 6e-05
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
KG R A ++Y G+++DELSF G E+ L E + W RG + G+ G++P N+VE +
Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEV-RGRTGIFPLNFVEPV 628
Score = 43.1 bits (100), Expect = 5e-04
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 368 PFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGR 427
P + + G+N + AL+ + + D+LSFK GD + L E + WCRGR
Sbjct: 644 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQIL-ERLDSDWCRGR 702
Query: 428 LDSGQLGLYPANYV 441
L + G++PA +V
Sbjct: 703 LQDRE-GIFPAVFV 715
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 384 DSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEA 443
DS L+D+ ++ D+L+ +G E+ L E+ + W RG + Q+G++PANYV+
Sbjct: 494 DSGAPHAVVLHDFPAEQVDDLNLTSG-EIVYLLEKIDTDWYRGNCRN-QIGIFPANYVKV 551
Query: 444 I 444
I
Sbjct: 552 I 552
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/261 (19%), Positives = 115/261 (44%), Gaps = 12/261 (4%)
Query: 25 YKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKGPQYGSLERAW 84
YK + +G C + + +Q+RA +E +Y + L A + + ++ + + AW
Sbjct: 14 YKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQN-TRKSCVSSAW 72
Query: 85 GAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQK 144
++LHQ++ + +LE +K + ++ K+ K ++ K
Sbjct: 73 AWASEGMKSTADLHQKLGKAI---ELEAIKPTYQVLNVQE-----KKRKSLDNEVEKTAN 124
Query: 145 PWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQK 204
+ AKK ++ K+ + +SK QS+T ++++KL +K+ K + ++K
Sbjct: 125 LVISNWNQQIKAKKKLMVSTKKHEALFQLVESSK--QSMTEKEKRKLLNKLTKSTEKLEK 182
Query: 205 TQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSY 264
E Y + T ++ +E ++ + E++R+ L L +H++L +
Sbjct: 183 EDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLF-GQTL 241
Query: 265 IHVYRELEQAIRGADAQEDLR 285
+ ++ AI D ++D++
Sbjct: 242 TTCHTQIHCAISKIDIEKDIQ 262
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 55.8 bits (133), Expect = 8e-08
Identities = 27/59 (45%), Positives = 40/59 (67%), Gaps = 2/59 (3%)
Query: 387 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLD-SGQLGLYPANYVEAI 444
G R RA+YDY ++DE+SF+ GD + + + D+ GW G ++ +G G+ PANYVEAI
Sbjct: 204 GKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDD-GWMYGTVERTGDTGMLPANYVEAI 261
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/58 (50%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 387 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
G+ ALYDY G+ DELSF D +T + DE GW RGR G GL+PANYV+ +
Sbjct: 430 GISAVALYDYQGEGSDELSFDPDDVITDIEMVDE-GWWRGRC-HGHFGLFPANYVKLL 485
>gi|38524622 formin binding protein 1 [Homo sapiens]
Length = 617
Score = 55.1 bits (131), Expect = 1e-07
Identities = 55/288 (19%), Positives = 128/288 (44%), Gaps = 20/288 (6%)
Query: 46 VQERAKIEKAYGQQLTDWAKRWR----QLIEKGPQYGSLERAWGAIMTEADKVSELHQEV 101
V+ER +IE +Y +QL + +K+++ E+ +Y S +A+ + + E + + H+ +
Sbjct: 32 VKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSC-KAFISNLNEMNDYAGQHEVI 90
Query: 102 KNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYH 161
N+ ++ + + + ++ ++ DG RKAQ+ K+LE++K+ +
Sbjct: 91 SENMASQIIVDLARYVQELKQER-------KSNFHDG-RKAQQHIETCWKQLESSKRRFE 142
Query: 162 LACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTP 221
CKE A + +VT +K + + Q + ++ Y +L+
Sbjct: 143 RDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQH 202
Query: 222 QYME-NMEQVFEQCQQFEEKRLVFLKEVL---LDIKRHLNLAENSSYIHVYRELEQAIRG 277
+Y ++ +F++ Q+ EE+R+V + E + ++ R + + + E +
Sbjct: 203 EYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQK 262
Query: 278 ADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEG 325
D+Q + ++S P + +FE++ + T + + EG
Sbjct: 263 NDSQLVIEAYKSGFEPPGDI---EFEDYTQPMKRTVSDNSLSNSRGEG 307
Score = 49.7 bits (117), Expect = 5e-06
Identities = 63/313 (20%), Positives = 127/313 (40%), Gaps = 76/313 (24%)
Query: 140 RKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQ--SVTPEQQ-KKLQDKVD 196
++ ++P + + E +K H + K ++ ++ + E ++ PEQ+ KKLQ KVD
Sbjct: 361 KQQKEPLSHRFNEFMTSKPKIH-CFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVD 419
Query: 197 KCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHL 256
+ +++QK ++ + + + +K+V L ++
Sbjct: 420 ELNKEIQKEMDQRDAITK------------------------------MKDVYL---KNP 446
Query: 257 NLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKK 316
+ + +S H E+ Q I E LR + +FE W ++ +
Sbjct: 447 QMGDPASLDHKLAEVSQNI------EKLR-----------VETQKFEAWLAEVEGRLPAR 489
Query: 317 EKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNG 376
+Q ++ G+ + V + +Q DR P + +++++S SE
Sbjct: 490 SEQARRQSGLYDSQNPPTVNNCAQ----------DRESPDGS-YTEEQSQE----SEMKV 534
Query: 377 GANPFEDDSKGVR-------VRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLD 429
A F+D+ +ALY ++GQ + +S G+ L + E+ GW R R +
Sbjct: 535 LATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRN 594
Query: 430 SGQLGLYPANYVE 442
+ G P +YVE
Sbjct: 595 EDEEGYVPTSYVE 607
>gi|226371725 FCH domain only 2 isoform b [Homo sapiens]
Length = 777
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/229 (22%), Positives = 98/229 (42%), Gaps = 15/229 (6%)
Query: 17 DSFWEVGN--YKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKG 74
++FW N + + G +L + V+ERA IE+AY + +T AK
Sbjct: 8 ENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS----ASNY 63
Query: 75 PQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKE 134
Q G+ W T +K++ H ++ L E +K QK Y ++ + K+TKE
Sbjct: 64 SQLGTFAPVWDVFKTSTEKLANCHLDLVRKL----QELIKEVQK--YGEEQVKSHKKTKE 117
Query: 135 AEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDK 194
G +A + + L+ +K+ Y+ C E++ + +E ++ E + KK D
Sbjct: 118 EVAGTLEAVQTIQSITQALQKSKENYNAKCVEQE-RLKKEGATQREIEKAAVKSKKATDT 176
Query: 195 VDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQ--VFEQCQQFEEKR 241
+ + +E+ + + + +++ NM V Q+F E +
Sbjct: 177 YKLYVEKYALAKADFEQKMTETAQVHEEFINNMANTTVESLIQKFAESK 225
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 55.1 bits (131), Expect = 1e-07
Identities = 63/297 (21%), Positives = 127/297 (42%), Gaps = 31/297 (10%)
Query: 174 EMNSKTEQSVTPEQQ--KKLQDKVDKCK--QDVQKTQEKYEKVLEDVGKTTPQYMENMEQ 229
++ T SVTPE + KK Q+ + K QD ++ + + +L+ + +N
Sbjct: 722 QLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHIS 781
Query: 230 VFEQCQQFEEKRLVFLKEVLLD-----IKRHLNLAENSSYIHVYRELEQAIRGADAQEDL 284
+ + + FE+ + V+ D ++++ + +++Y V+ + + R DL
Sbjct: 782 MVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDL 841
Query: 285 RWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDR 344
+ +R+ G ++ P + H ++K ++ + +++T T DR
Sbjct: 842 KVWRTDPGSIFDLD-PLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFG---TGLGDDR 897
Query: 345 GSVSSY--------------DRGQPYATEWSDDESGNPFGGS-ETNGGANPFEDDSKGVR 389
+S D G P +G +T+ + S +R
Sbjct: 898 SEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLR 957
Query: 390 V-RALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLD-SGQLGLYPANYVEAI 444
RA+YDY Q++DE+SF+ GD + + D+ GW G + +G+ G+ PANY+E +
Sbjct: 958 TYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDD-GWMYGTVQRTGRTGMLPANYIEFV 1013
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 54.3 bits (129), Expect = 2e-07
Identities = 40/140 (28%), Positives = 66/140 (47%), Gaps = 13/140 (9%)
Query: 315 KKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWS---------DDES 365
+ +Q + A ++++ E S+A D +S+Y G +A + +
Sbjct: 6533 RSREQSRSASALSISGGEEKSEH-SEAPDH-HLSTYSDGGVFAVSTAYKHAKTTELPQQR 6590
Query: 366 GNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCR 425
+ +T + P + G RA+YDY + DE+SFK GD + + DE GW
Sbjct: 6591 SSSVATQQTTVSSIPSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDE-GWMY 6649
Query: 426 GRLD-SGQLGLYPANYVEAI 444
G + +G+ G+ PANYVEAI
Sbjct: 6650 GTVQRTGRTGMLPANYVEAI 6669
Score = 32.3 bits (72), Expect = 0.89
Identities = 53/215 (24%), Positives = 92/215 (42%), Gaps = 31/215 (14%)
Query: 91 ADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKE--AEDGFRKAQKPWAK 148
A K ++L +VK N D EK K + + Q+ K+ +E ++ K K
Sbjct: 5783 AKKAAKLSSQVKYRE-NFDKEKGKTPKYNPKDSQLYKVMKDANNLASEVKYKADLKKLHK 5841
Query: 149 KMKELEAAKKAYHLACKEEKLAMTREMNSKTEQS-----VTPEQQKKLQDKVDKCKQDVQ 203
+ +++ + H+ +LA + + K E+S P+ ++L K Q +
Sbjct: 5842 PVTDMKESLIMNHVL-NTSQLASSYQYKKKYEKSKGHYHTIPDNLEQLHLKEATELQSIV 5900
Query: 204 KTQEKYEKVLEDVGK-----TTPQYM-----ENMEQVFEQCQQFEE----KRLVFLK--E 247
K +EKYEK + GK TP Y+ + M+ E + +EE + L L+
Sbjct: 5901 KYKEKYEK---ERGKPMLDFETPTYITAKESQQMQSGKEYRKDYEESIKGRNLTGLEVTP 5957
Query: 248 VLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQE 282
LL +K +A Y ++LE++IRG E
Sbjct: 5958 ALLHVKYATKIASEKEY---RKDLEESIRGKGLTE 5989
Score = 29.3 bits (64), Expect = 7.5
Identities = 58/257 (22%), Positives = 98/257 (38%), Gaps = 40/257 (15%)
Query: 87 IMTEADKVSELHQEVKNNLLNE-----DLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRK 141
I +E + +L + ++ L E D+ + KN + K+ +K E E R
Sbjct: 5968 IASEKEYRKDLEESIRGKGLTEMEDTPDMLRAKNATQILNEKE----YKRDLELEVKGR- 6022
Query: 142 AQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSV--TPE----QQKKLQDKV 195
A + + A+ A +A + K + EM SV TPE QQ K
Sbjct: 6023 GLNAMANETPDFMRARNATDIA-SQIKYKQSAEMEKANFTSVVDTPEIIHAQQVKNLSSQ 6081
Query: 196 DKCKQDVQKTQEKYEKVLEDVG-KTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKR 254
K K+D +K+ YE VL+ + + +N + QC K + + + +I R
Sbjct: 6082 KKYKEDAEKSMSYYETVLDTPEIQRVRENQKNFSLLQYQCDLKNSKGKITVVQDTPEILR 6141
Query: 255 HLNLAENSSYIHVYRE----------LEQAIRGADAQEDLR--WFRSTSGPGMPMNWPQF 302
+N S + +Y+E + +R Q+ + ++ G G P+
Sbjct: 6142 VKENQKNFSSV-LYKEDVSPGTAIGKTPEMMRVKQTQDHISSVKYKEAIGQGTPI----- 6195
Query: 303 EEWNPDLPHTTTKKEKQ 319
PDLP KE Q
Sbjct: 6196 ----PDLPEVKRVKETQ 6208
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 52.8 bits (125), Expect = 6e-07
Identities = 25/58 (43%), Positives = 40/58 (68%), Gaps = 2/58 (3%)
Query: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEA 443
+G +VRA+YD++ E +EL+FKAG+ +T L + D W +G G +GL+P+N+V A
Sbjct: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSD-PNWWKGETHQG-IGLFPSNFVTA 266
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 52.4 bits (124), Expect = 8e-07
Identities = 27/79 (34%), Positives = 47/79 (59%), Gaps = 2/79 (2%)
Query: 366 GNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCR 425
G P GG + + + +K + + L++Y Q +DEL K GD + + EE E+GW
Sbjct: 89 GLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGD-IIDINEEVEEGWWS 147
Query: 426 GRLDSGQLGLYPANYVEAI 444
G L++ +LGL+P+N+V+ +
Sbjct: 148 GTLNN-KLGLFPSNFVKEL 165
Score = 45.1 bits (105), Expect = 1e-04
Identities = 19/51 (37%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 394 YDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
YDYD DEL+ + G+ + + + E+GW G L +G+ G++P N+V+ I
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGEL-NGRRGMFPDNFVKEI 57
Score = 43.9 bits (102), Expect = 3e-04
Identities = 22/55 (40%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Query: 391 RALYDYDGQEQDELSFKAGDELTKLGEE-DEQGWCRGRLDSGQLGLYPANYVEAI 444
R L+ Y+G +DEL+FK G+ + + +E E GW RG L +G+ G++P N+ I
Sbjct: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGEL-NGKEGVFPDNFAVQI 328
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 52.4 bits (124), Expect = 8e-07
Identities = 24/55 (43%), Positives = 37/55 (67%), Gaps = 2/55 (3%)
Query: 388 VRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQ-GWCRGRLDSGQLGLYPANYV 441
+ V ALY ++GQ+ +L+F+AGD +T + + D W G+L GQ G++PANYV
Sbjct: 267 IEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKL-RGQTGIFPANYV 320
>gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo
sapiens]
Length = 342
Score = 52.4 bits (124), Expect = 8e-07
Identities = 24/55 (43%), Positives = 37/55 (67%), Gaps = 2/55 (3%)
Query: 388 VRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQ-GWCRGRLDSGQLGLYPANYV 441
+ V ALY ++GQ+ +L+F+AGD +T + + D W G+L GQ G++PANYV
Sbjct: 286 IEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKL-RGQTGIFPANYV 339
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 52.4 bits (124), Expect = 8e-07
Identities = 28/54 (51%), Positives = 35/54 (64%), Gaps = 2/54 (3%)
Query: 391 RALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
+ALY YD Q+ DELSF A D + + +ED GW GRL G+ GL+P NYV I
Sbjct: 1057 KALYAYDAQDTDELSFNAND-IIDIIKEDPSGWWTGRL-RGKQGLFPNNYVTKI 1108
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/300 (21%), Positives = 127/300 (42%), Gaps = 42/300 (14%)
Query: 17 DSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKI------------------EKAYGQ 58
+ WE R K++ + + D +QE +I EK Q
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 59 QLTDWA---KRWRQLIEKGPQYGSLERAWGA--IMTEADKVSELHQEVKNNLLNEDLEKV 113
+ W K W+Q ++ P+ E+ W + + +K+ E +++++ EK
Sbjct: 477 EENMWEQEEKEWQQ--QRLPE--QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK- 531
Query: 114 KNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPW------AKKMKELEAAKKAYHLACKEE 167
K W+++ +Q +++ ++ D + QK W KK +E E +EE
Sbjct: 532 KMWRQEKMREQEDQMWEQEEKMRD---QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 168 KLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENM 227
+ RE + E+ + EQ++K+Q++ +K ++ +K E+ EK+ E K E
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK----MWEQE 644
Query: 228 EQVFEQCQQ-FEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRW 286
E+++EQ ++ +E++RL KE L + ++ + E E+ + QE W
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/293 (20%), Positives = 130/293 (44%), Gaps = 24/293 (8%)
Query: 46 VQERAKIEKAYGQQLTDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEV--KN 103
++ER K + + + + ++ ++ EK + E+ W + +K+ E +++ +
Sbjct: 591 MREREKKMREEEEMMREQEEKMQEQEEKMQEQE--EKMW----EQEEKMQEQEEKMWEQE 644
Query: 104 NLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKEL---EAAKKAY 160
+ E EK+ Q+ K+ + ++ +E E + +K W ++ E E KK +
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 161 HLA-CKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKT 219
+EE+ RE + E+ + EQ++K+Q++ +K ++ ++ E+ EK+ E K
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Query: 220 TPQYM--ENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRG 277
Q E E+++E + E++++ +E + D + + E R E+ +RG
Sbjct: 765 WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK-----MRGQEEKMRG 819
Query: 278 AD----AQEDLRWFRSTSGPGMPMN-WPQFEEWNPDLPHTTTKKEKQPKKAEG 325
+ QE+ W + G W Q E+ + K +Q +K G
Sbjct: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG 872
Score = 39.3 bits (90), Expect = 0.007
Identities = 40/169 (23%), Positives = 77/169 (45%), Gaps = 19/169 (11%)
Query: 88 MTEADKVSELHQEVKNNLLNEDLEKVK----NWQKDAYHKQIMGGFKETKEAEDGFRKAQ 143
+ E++K SE+ VK L LE+ K Q + +++ +E +E E RK +
Sbjct: 236 LAESEK-SEIQLNVKE--LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQE 292
Query: 144 -KPWAK---------KMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQD 193
K W + KM+E E +E++ + + EQ EQ++++Q+
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQE 352
Query: 194 KVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRL 242
+ +K + +K +E+ EK+ + Q + EQ EQ + +E+R+
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ--EQKMRDQEERM 399
Score = 35.0 bits (79), Expect = 0.14
Identities = 70/358 (19%), Positives = 147/358 (41%), Gaps = 49/358 (13%)
Query: 9 SLAPEETTD-------SFWEVGNYKRTVKRIDDGHRLCNDLMN-CVQERAKIE-KAYGQQ 59
SL P E+ D S+ G +R + + H+ + + +ER + + Y
Sbjct: 158 SLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNT 217
Query: 60 LT--DWAKRWRQLIEKGP----QYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDL--- 110
+T + K+ +L EK P + ++ + + ++ L +V+ N L E++
Sbjct: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277
Query: 111 -EKVKNWQKDAY-HKQIMGGFKETKEAEDGFRKAQ--KPWA--KKMKELEAAKKAYHLAC 164
E+++ +K ++ M +E ++G + Q K W K+++E E +
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 165 KEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQ-- 222
+E+K +E + ++ EQ++K++++ +K + ++ E+ +++ E K Q
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 223 --------------YMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVY 268
M E+++EQ ++ E++ + +E K+ + E
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE-----KKTRDQEEKMQEEERI 452
Query: 269 RELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFE-EWNPD-LPHTTTKKEKQPKKAE 324
RE E+ +R + +E +R W Q E EW LP K +Q K E
Sbjct: 453 REREKKMR--EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Score = 29.3 bits (64), Expect = 7.5
Identities = 32/157 (20%), Positives = 75/157 (47%), Gaps = 20/157 (12%)
Query: 88 MTEADKVSELHQEVKNN--LLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKP 145
M E +++ E ++++ ++ E EK++ ++ ++ +E K E + +K
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE----QEEKM 640
Query: 146 WAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKT 205
W ++ K E +K + ++++L E K + ++Q+K+Q++ +K +
Sbjct: 641 WEQEEKMWEQEEKMW----EQQRLP---EQKEKLWEHEKMQEQEKMQEQEEKIWE----- 688
Query: 206 QEKYEKVLEDVGKTT--PQYMENMEQVFEQCQQFEEK 240
QEK EK ++ K T + M E + E+ ++ E+
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 51.2 bits (121), Expect = 2e-06
Identities = 31/86 (36%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 359 EWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEE 418
E+ +S P GG G P RALYD++ + + EL FK GD +T +
Sbjct: 264 EFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQI 323
Query: 419 DEQGWCRGRLDSGQLGLYPANYVEAI 444
DE W G L G G +P NYVE +
Sbjct: 324 DE-NWYEGML-HGHSGFFPINYVEIL 347
>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
Length = 551
Score = 50.8 bits (120), Expect = 2e-06
Identities = 98/514 (19%), Positives = 184/514 (35%), Gaps = 125/514 (24%)
Query: 46 VQERAKIEKAYGQQLTDWAKRW---RQLIEKGPQYGSL---------------------- 80
V+ER +IE+ Y +QL + K++ R ++ P++ S
Sbjct: 32 VKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAE 91
Query: 81 ---ERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNW------QKDAYHKQIMGGFKE 131
R +G +M A +L E K +L ++ K + + Q D K+ +E
Sbjct: 92 EMAHRVYGELMRYAH---DLKTERKMHL--QEGRKAQQYLDMCWKQMDNSKKKFERECRE 146
Query: 132 TKEAEDGFRKAQKPWAKKMKELEAAKKAYHLAC------KEEKLAMTREMNSKTEQS--- 182
++A+ + + ++E AK+ +L K E A + N + +
Sbjct: 147 AEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYV 206
Query: 183 VTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKR- 241
V P+ K+LQ+ ++ K E Y + K P + +E + + +E+R
Sbjct: 207 VIPQIYKQLQEMDER---RTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRD 263
Query: 242 -LVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRW-FRSTSGPGMPMNW 299
+ + + + H+YR + A QE + ++T G W
Sbjct: 264 SQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLW 323
Query: 300 --------PQFEEWNPDLPHTTTKK----------EKQPKKAEGVALTNATGAVESTSQA 341
P E+++ P KK E Q + + AL E Q
Sbjct: 324 LFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQM 383
Query: 342 GDRGSV--------SSYDR-------GQPYATE--------------------------- 359
GD GS+ ++ DR + + +E
Sbjct: 384 GDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRES 443
Query: 360 ----WSDDESGNPFGGSETNGGANPFEDDSKGV-------RVRALYDYDGQEQDELSFKA 408
++DD + G + +G N F+D+ + +A+Y +DG + L+ K
Sbjct: 444 PEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKE 503
Query: 409 GDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
G+ L + E+ GW R R +G+ G P +Y++
Sbjct: 504 GEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
Length = 547
Score = 50.8 bits (120), Expect = 2e-06
Identities = 98/514 (19%), Positives = 184/514 (35%), Gaps = 125/514 (24%)
Query: 46 VQERAKIEKAYGQQLTDWAKRW---RQLIEKGPQYGSL---------------------- 80
V+ER +IE+ Y +QL + K++ R ++ P++ S
Sbjct: 32 VKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAE 91
Query: 81 ---ERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNW------QKDAYHKQIMGGFKE 131
R +G +M A +L E K +L ++ K + + Q D K+ +E
Sbjct: 92 EMAHRVYGELMRYAH---DLKTERKMHL--QEGRKAQQYLDMCWKQMDNSKKKFERECRE 146
Query: 132 TKEAEDGFRKAQKPWAKKMKELEAAKKAYHLAC------KEEKLAMTREMNSKTEQS--- 182
++A+ + + ++E AK+ +L K E A + N + +
Sbjct: 147 AEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYV 206
Query: 183 VTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKR- 241
V P+ K+LQ+ ++ K E Y + K P + +E + + +E+R
Sbjct: 207 VIPQIYKQLQEMDER---RTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRD 263
Query: 242 -LVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRW-FRSTSGPGMPMNW 299
+ + + + H+YR + A QE + ++T G W
Sbjct: 264 SQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLW 323
Query: 300 --------PQFEEWNPDLPHTTTKK----------EKQPKKAEGVALTNATGAVESTSQA 341
P E+++ P KK E Q + + AL E Q
Sbjct: 324 LFGKKPKGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQM 383
Query: 342 GDRGSV--------SSYDR-------GQPYATE--------------------------- 359
GD GS+ ++ DR + + +E
Sbjct: 384 GDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRES 443
Query: 360 ----WSDDESGNPFGGSETNGGANPFEDDSKGV-------RVRALYDYDGQEQDELSFKA 408
++DD + G + +G N F+D+ + +A+Y +DG + L+ K
Sbjct: 444 PEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKE 503
Query: 409 GDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
G+ L + E+ GW R R +G+ G P +Y++
Sbjct: 504 GEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 537
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 50.8 bits (120), Expect = 2e-06
Identities = 68/320 (21%), Positives = 127/320 (39%), Gaps = 49/320 (15%)
Query: 151 KELEAAKKAYHLACKE-----EKLAMTREMNSKT--EQSVTPEQQKKLQDK--------- 194
+E+E+ K+ L E ++L +++M + E+ + +Q K++Q
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVT 567
Query: 195 VDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEE--KRLVFLKEVLLDI 252
+ + + + ++ L++V K T ++ ++ Q ++ E + K+ ++
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEA 627
Query: 253 KRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHT 312
+R + I + ++ E+A R A + D +W + E P H
Sbjct: 628 ERLKQKEQERKIIELEKQKEEAQRRAQ-ERDKQWLEHVQ--------QEDEHQRPRKLHE 678
Query: 313 TTK--KEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFG 370
K +E+ KK +G G E+ + G WS E G P
Sbjct: 679 EEKLKREESVKKKDG----EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKG-PLT 733
Query: 371 GSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE------EDEQGWC 424
S +++ K V RALY ++ + DE++ + GD + GE E GW
Sbjct: 734 ISA--------QENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 425 RGRLDSGQLGLYPANYVEAI 444
G L G+ G +PANY E I
Sbjct: 786 GGEL-KGKTGWFPANYAEKI 804
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/54 (42%), Positives = 35/54 (64%), Gaps = 2/54 (3%)
Query: 389 RVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
+V +YDY Q DEL+F G + L +ED W +G + +GQ+GL+P+NYV+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPD-WWKGEV-NGQVGLFPSNYVK 1210
Score = 41.2 bits (95), Expect = 0.002
Identities = 83/407 (20%), Positives = 165/407 (40%), Gaps = 60/407 (14%)
Query: 76 QYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAY-----HKQIMGGFK 130
Q +E+ + + E D + +E++ + L+K K+ + + ++I+ K
Sbjct: 585 QLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEK 644
Query: 131 ETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPE--QQ 188
+ +EA+ ++ K W + +++ + ++ L +EEKL K E+SV + ++
Sbjct: 645 QKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLH-EEEKL--------KREESVKKKDGEE 695
Query: 189 KKLQDKVDKCKQDVQKTQEKYEKVLE------DVGKTTPQYMENMEQVFEQCQQFEEKRL 242
K Q+ DK + + QE + ++ + G T EN++ V+ + E R
Sbjct: 696 KGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESR- 754
Query: 243 VFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQF 302
+ I+ + ++ + E G + + WF + +P N
Sbjct: 755 ---SHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN---- 807
Query: 303 EEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATE--- 359
E P P T + PK A + T A AV S+ + + + + P +T
Sbjct: 808 EVPAPVKPVTDSTSAPAPKLA--LRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKP 865
Query: 360 -------WSDDESGN-PFGGS---------ETNGGANPFE-----DDSKGVRVRALYDYD 397
W+ S P G T G++P + +G++ +ALY +
Sbjct: 866 ETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWR 925
Query: 398 GQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
++ + L+F D +T L ++D W G + GQ G +P +YV+ I
Sbjct: 926 AKKDNHLNFNKNDVITVLEQQDM--WWFGEV-QGQKGWFPKSYVKLI 969
Score = 34.3 bits (77), Expect = 0.23
Identities = 17/50 (34%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Query: 392 ALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYV 441
A+Y Y+ EQ +L+F+ GD + L + + W G + + G++P+NYV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVI--LVTKKDGDWWTGTV-GDKAGVFPSNYV 1055
Score = 31.6 bits (70), Expect = 1.5
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 371 GSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDS 430
GS T G + +V A Y G EQ L A +L + +++ GW G L +
Sbjct: 1062 GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL---APGQLILIRKKNPGGWWEGELQA 1118
Query: 431 G----QLGLYPANYVEAI 444
Q+G +PANYV+ +
Sbjct: 1119 RGKKRQIGWFPANYVKLL 1136
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 50.8 bits (120), Expect = 2e-06
Identities = 68/320 (21%), Positives = 127/320 (39%), Gaps = 49/320 (15%)
Query: 151 KELEAAKKAYHLACKE-----EKLAMTREMNSKT--EQSVTPEQQKKLQDK--------- 194
+E+E+ K+ L E ++L +++M + E+ + +Q K++Q
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVT 567
Query: 195 VDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEE--KRLVFLKEVLLDI 252
+ + + + ++ L++V K T ++ ++ Q ++ E + K+ ++
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEA 627
Query: 253 KRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHT 312
+R + I + ++ E+A R A + D +W + E P H
Sbjct: 628 ERLKQKEQERKIIELEKQKEEAQRRAQ-ERDKQWLEHVQ--------QEDEHQRPRKLHE 678
Query: 313 TTK--KEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFG 370
K +E+ KK +G G E+ + G WS E G P
Sbjct: 679 EEKLKREESVKKKDG----EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKG-PLT 733
Query: 371 GSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE------EDEQGWC 424
S +++ K V RALY ++ + DE++ + GD + GE E GW
Sbjct: 734 ISA--------QENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 425 RGRLDSGQLGLYPANYVEAI 444
G L G+ G +PANY E I
Sbjct: 786 GGEL-KGKTGWFPANYAEKI 804
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/54 (42%), Positives = 35/54 (64%), Gaps = 2/54 (3%)
Query: 389 RVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
+V +YDY Q DEL+F G + L +ED W +G + +GQ+GL+P+NYV+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPD-WWKGEV-NGQVGLFPSNYVK 1210
Score = 41.2 bits (95), Expect = 0.002
Identities = 83/407 (20%), Positives = 165/407 (40%), Gaps = 60/407 (14%)
Query: 76 QYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAY-----HKQIMGGFK 130
Q +E+ + + E D + +E++ + L+K K+ + + ++I+ K
Sbjct: 585 QLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEK 644
Query: 131 ETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPE--QQ 188
+ +EA+ ++ K W + +++ + ++ L +EEKL K E+SV + ++
Sbjct: 645 QKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLH-EEEKL--------KREESVKKKDGEE 695
Query: 189 KKLQDKVDKCKQDVQKTQEKYEKVLE------DVGKTTPQYMENMEQVFEQCQQFEEKRL 242
K Q+ DK + + QE + ++ + G T EN++ V+ + E R
Sbjct: 696 KGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESR- 754
Query: 243 VFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQF 302
+ I+ + ++ + E G + + WF + +P N
Sbjct: 755 ---SHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN---- 807
Query: 303 EEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATE--- 359
E P P T + PK A + T A AV S+ + + + + P +T
Sbjct: 808 EVPAPVKPVTDSTSAPAPKLA--LRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKP 865
Query: 360 -------WSDDESGN-PFGGS---------ETNGGANPFE-----DDSKGVRVRALYDYD 397
W+ S P G T G++P + +G++ +ALY +
Sbjct: 866 ETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWR 925
Query: 398 GQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
++ + L+F D +T L ++D W G + GQ G +P +YV+ I
Sbjct: 926 AKKDNHLNFNKNDVITVLEQQDM--WWFGEV-QGQKGWFPKSYVKLI 969
Score = 34.3 bits (77), Expect = 0.23
Identities = 17/50 (34%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Query: 392 ALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYV 441
A+Y Y+ EQ +L+F+ GD + L + + W G + + G++P+NYV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVI--LVTKKDGDWWTGTV-GDKAGVFPSNYV 1055
Score = 31.6 bits (70), Expect = 1.5
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 371 GSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDS 430
GS T G + +V A Y G EQ L A +L + +++ GW G L +
Sbjct: 1062 GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL---APGQLILIRKKNPGGWWEGELQA 1118
Query: 431 G----QLGLYPANYVEAI 444
Q+G +PANYV+ +
Sbjct: 1119 RGKKRQIGWFPANYVKLL 1136
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,785,287
Number of Sequences: 37866
Number of extensions: 832178
Number of successful extensions: 4979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 527
Number of HSP's that attempted gapping in prelim test: 3570
Number of HSP's gapped (non-prelim): 1471
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.