Guide to the Human Genome
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Search of human proteins with 24307991

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24307991 p53-associated parkin-like cytoplasmic protein
[Homo sapiens]
         (2517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo...  5105   0.0  
gi|41872646 cullin 7 [Homo sapiens]                                  1336   0.0  
gi|5453557 ariadne homolog 2 [Homo sapiens]                           177   1e-43
gi|187761373 ariadne ubiquitin-conjugating enzyme E2 binding pro...   149   3e-35
gi|148596953 ankyrin repeat and IBR domain containing 1 [Homo sa...   136   3e-31
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      95   8e-19
gi|157738609 HECT domain containing 3 [Homo sapiens]                   94   2e-18
gi|73747881 zinc finger, ZZ type with EF hand domain 1 [Homo sap...    93   4e-18
gi|34577102 ring finger protein 14 isoform 1 [Homo sapiens]            91   2e-17
gi|34577100 ring finger protein 14 isoform 1 [Homo sapiens]            91   2e-17
gi|34577098 ring finger protein 14 isoform 1 [Homo sapiens]            91   2e-17
gi|34577096 ring finger protein 14 isoform 2 [Homo sapiens]            91   2e-17
gi|4757762 ring finger protein 14 isoform 1 [Homo sapiens]             91   2e-17
gi|188219579 ring finger protein 19B isoform b [Homo sapiens]          89   5e-17
gi|188219577 ring finger protein 19B isoform a [Homo sapiens]          89   7e-17
gi|35493801 ring finger protein 19 [Homo sapiens]                      83   4e-15
gi|35493782 ring finger protein 19 [Homo sapiens]                      83   4e-15
gi|38045938 ring finger protein 144 [Homo sapiens]                     77   3e-13
gi|169790973 parkin isoform 3 [Homo sapiens]                           67   2e-10
gi|169790971 parkin isoform 2 [Homo sapiens]                           67   2e-10
gi|169790969 parkin isoform 1 [Homo sapiens]                           67   2e-10
gi|50284696 IBR domain containing 2 [Homo sapiens]                     65   6e-10
gi|109150431 ring finger protein 31 [Homo sapiens]                     59   8e-08
gi|115529449 upstream binding transcription factor, RNA polymera...    56   5e-07
gi|115529451 upstream binding transcription factor, RNA polymera...    56   5e-07
gi|7657671 upstream binding transcription factor, RNA polymerase...    56   5e-07
gi|5454168 RanBP-type and C3HC4-type zinc finger containing 1 is...    55   7e-07
gi|144953898 RanBP-type and C3HC4-type zinc finger containing 1 ...    55   7e-07
gi|22749145 ring finger protein 217 [Homo sapiens]                     55   1e-06
gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein ...    49   8e-05

>gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo
            sapiens]
          Length = 2517

 Score = 5105 bits (13243), Expect = 0.0
 Identities = 2517/2517 (100%), Positives = 2517/2517 (100%)

Query: 1    MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKA 60
            MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKA
Sbjct: 1    MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKA 60

Query: 61   EHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQ 120
            EHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQ
Sbjct: 61   EHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQ 120

Query: 121  ALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEP 180
            ALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEP
Sbjct: 121  ALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEP 180

Query: 181  QIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHC 240
            QIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHC
Sbjct: 181  QIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHC 240

Query: 241  MAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQREL 300
            MAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQREL
Sbjct: 241  MAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQREL 300

Query: 301  EFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQG 360
            EFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQG
Sbjct: 301  EFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQG 360

Query: 361  WVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFW 420
            WVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFW
Sbjct: 361  WVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFW 420

Query: 421  QSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPY 480
            QSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPY
Sbjct: 421  QSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPY 480

Query: 481  LQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVS 540
            LQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVS
Sbjct: 481  LQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVS 540

Query: 541  VEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKS 600
            VEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKS
Sbjct: 541  VEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKS 600

Query: 601  EASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEA 660
            EASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEA
Sbjct: 601  EASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEA 660

Query: 661  ASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLV 720
            ASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLV
Sbjct: 661  ASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLV 720

Query: 721  RPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVC 780
            RPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVC
Sbjct: 721  RPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVC 780

Query: 781  MQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATR 840
            MQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATR
Sbjct: 781  MQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATR 840

Query: 841  PGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRH 900
            PGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRH
Sbjct: 841  PGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRH 900

Query: 901  SGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPS 960
            SGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPS
Sbjct: 901  SGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPS 960

Query: 961  AELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVIT 1020
            AELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVIT
Sbjct: 961  AELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVIT 1020

Query: 1021 RLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGA 1080
            RLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGA
Sbjct: 1021 RLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGA 1080

Query: 1081 KEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRT 1140
            KEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRT
Sbjct: 1081 KEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRT 1140

Query: 1141 HQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGST 1200
            HQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGST
Sbjct: 1141 HQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGST 1200

Query: 1201 GSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASR 1260
            GSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASR
Sbjct: 1201 GSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASR 1260

Query: 1261 VILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI 1320
            VILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI
Sbjct: 1261 VILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI 1320

Query: 1321 RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLV 1380
            RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLV
Sbjct: 1321 RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLV 1380

Query: 1381 QNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSP 1440
            QNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSP
Sbjct: 1381 QNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSP 1440

Query: 1441 EPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPR 1500
            EPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPR
Sbjct: 1441 EPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPR 1500

Query: 1501 YCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGG 1560
            YCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGG
Sbjct: 1501 YCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGG 1560

Query: 1561 LIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQ 1620
            LIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQ
Sbjct: 1561 LIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQ 1620

Query: 1621 IGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEE 1680
            IGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEE
Sbjct: 1621 IGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEE 1680

Query: 1681 EAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQN 1740
            EAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQN
Sbjct: 1681 EAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQN 1740

Query: 1741 HPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLS 1800
            HPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLS
Sbjct: 1741 HPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLS 1800

Query: 1801 PELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRSGEALWLIPPQAYLNVEKD 1860
            PELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRSGEALWLIPPQAYLNVEKD
Sbjct: 1801 PELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRSGEALWLIPPQAYLNVEKD 1860

Query: 1861 EGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVA 1920
            EGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVA
Sbjct: 1861 EGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVA 1920

Query: 1921 CTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSP 1980
            CTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSP
Sbjct: 1921 CTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSP 1980

Query: 1981 EAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQ 2040
            EAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQ
Sbjct: 1981 EAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQ 2040

Query: 2041 SYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEY 2100
            SYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEY
Sbjct: 2041 SYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEY 2100

Query: 2101 LTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWC 2160
            LTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWC
Sbjct: 2101 LTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWC 2160

Query: 2161 TNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMS 2220
            TNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMS
Sbjct: 2161 TNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMS 2220

Query: 2221 VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS 2280
            VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS
Sbjct: 2221 VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS 2280

Query: 2281 AMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLE 2340
            AMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLE
Sbjct: 2281 AMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLE 2340

Query: 2341 QARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLL 2400
            QARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLL
Sbjct: 2341 QARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLL 2400

Query: 2401 RADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGP 2460
            RADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGP
Sbjct: 2401 RADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGP 2460

Query: 2461 EAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD 2517
            EAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD
Sbjct: 2461 EAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD 2517


>gi|41872646 cullin 7 [Homo sapiens]
          Length = 1698

 Score = 1336 bits (3457), Expect = 0.0
 Identities = 677/1065 (63%), Positives = 827/1065 (77%), Gaps = 32/1065 (3%)

Query: 918  MMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGG--PSAELLLDLERVLCREG 975
            ++LL+  ++   S + A +E      Q  SP   ++ LV G  P+ ++LLDLE+ L  EG
Sbjct: 589  VLLLDAQAQAKDSEDAAKVEAKEPPSQ--SPNTPLQRLVEGYGPAGKILLDLEQALSSEG 646

Query: 976  SPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVITRLLDFPEAMVLPWHE 1035
            +    V+PLL +LQ++ QPFL L+++LD P  N+TL L+VLR++ +L+DFPEA++LPWHE
Sbjct: 647  TQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHE 706

Query: 1036 VLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGAKEILSKVLDKHSAQL 1095
             ++ C+ CL  P++D E++QEL  FLHRL S+ +DYAVVL  LGA++ +SK L+KH  +L
Sbjct: 707  AVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKL 766

Query: 1096 LLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFLRH 1155
             L  ELRD+V +CEK+A LY  L ++IL GCIQMVLGQIEDHRRTHQPINIPFFDVFLR+
Sbjct: 767  ELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRY 826

Query: 1156 LCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLV 1215
            LCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGS GSHYITLHM RG+L+
Sbjct: 827  LCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILI 886

Query: 1216 RQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASRVILLENLNRFWPIIQ 1275
            RQLTLLVASEDSSYMPARVVV GGDSTS + TELN+VNVMPSASRVILLENL RFWPIIQ
Sbjct: 887  RQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQ 946

Query: 1276 IRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRR 1335
            IRIKRCQQGGIDTR+RG+E+LGPKPTFWP+FREQLCR T LFY +RAQAWS+D+AED R 
Sbjct: 947  IRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRS 1006

Query: 1336 LLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALG 1395
            LL L  RLN  LR EQNFADRFLPDDEAAQALGKTCWEALVSP+VQNITSPD +G+S LG
Sbjct: 1007 LLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLG 1066

Query: 1396 WLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSPEPST-RPFSKNSKGR 1454
            WLLDQYLE +E   NP SR  +F SRVRRL HLLVHVEP   P P  +T RP  +N +  
Sbjct: 1067 WLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRN-RSH 1125

Query: 1455 DRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSE 1514
            D S   +  LPSS +RN+T+CW +VV++QV+ FL ++WR  DFVPRYC+ +  LQ + SE
Sbjct: 1126 DWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSE 1185

Query: 1515 LFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQL 1574
            LFGPRAAF+LAL++G +GALL+  FL AAH+SEQFAR+IDQQIQG  IGGA  +E L QL
Sbjct: 1186 LFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQL 1245

Query: 1575 QRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLML 1634
            Q+ L+ +++ SGLE+ATTFEH+YQHYMADRLL   SSWLEGAVLEQIG CFPNRLPQ ML
Sbjct: 1246 QQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQML 1305

Query: 1635 QSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEK------------RLEEEEEE------ 1676
            QSLSTS+ELQRQFH++QLQ+LD+  L+ ED E+K            + E+EEE       
Sbjct: 1306 QSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVV 1365

Query: 1677 -----EEEEEAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRF 1731
                 EEEEE  ++L+ E   P +S+LVLS   WPV+ +C+  +PR CLP+     L+R+
Sbjct: 1366 DVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRY 1425

Query: 1732 SSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVE 1791
            S+FY++SQ+HP L+ G  RRLQWTWLG AELQFG Q LHVSTVQMWLLL  N  + VSVE
Sbjct: 1426 SNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVE 1485

Query: 1792 TLLKDSDLSPELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPG--PQRSGEALWLI 1849
            +LL  S LS ++L QA+ PLTS  GPL LHE +D P GGVL++ +    P+   + + LI
Sbjct: 1486 SLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIP-GGVLKIRDGSKEPRSRWDIVRLI 1544

Query: 1850 PPQAYLNVEKDEGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPG 1909
            PPQ YL  E ++G+ LE++RNLL+CL+VRILKAHG++GLHIDQLVCLVLEAWQKGP PP 
Sbjct: 1545 PPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPR 1604

Query: 1910 TLGHTVAGGVACTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAP 1954
             L  ++  G AC+STDVLSCILHLLG+G ++R DDRPQ+L YA P
Sbjct: 1605 GLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVP 1649



 Score =  607 bits (1566), Expect = e-173
 Identities = 342/637 (53%), Positives = 434/637 (68%), Gaps = 29/637 (4%)

Query: 1   MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGK--VGVEEG 58
           MVGE    +  VPLGP L AYP+ELIRQR GHDGHPEY IRW +L+ G+ G    G  + 
Sbjct: 1   MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC 60

Query: 59  KAEHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEAD 118
           KAEHIL+W+S  E+YANC  +LGE     G   E AG       + G LD+  + EME D
Sbjct: 61  KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAG-------EVGALDKSVLEEMETD 113

Query: 119 VQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNP 178
           V++L++RA RQL E       A +LHT+HVLSAYASI PLTGVF++   LDLLMHML +P
Sbjct: 114 VKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSP 173

Query: 179 EPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEE 238
           + QIR SAG+M+QAL++HDAG+R  +LLSLSQQ+ IE+H+DFDSR  LL LFA+ T S E
Sbjct: 174 DYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLS-E 232

Query: 239 HCMAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLN-SSPELGAGDQSSPCATREKSRGQ 297
           H M+FEGI LPQ+PG++LFSLVKRYL VTSLLDQLN S+ E GA + S+P       RGQ
Sbjct: 233 HPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAP-EELSGERGQ 291

Query: 298 RELEFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPR 357
            ELEFSMA+G LISELV++M W +  S++  S  R   SIFQP ++  S  LP     P 
Sbjct: 292 LELEFSMAMGTLISELVQAMRWDQ-ASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPS 350

Query: 358 -RQGWVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPV 416
            R+   FR RSEF+S + Y  YV+ TLQPGMRVRMLDDYEEISAGDEGEFRQSNNG+PPV
Sbjct: 351 FRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPV 410

Query: 417 QVFWQSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGAT-VLGTAFPSWDWNPMDGL 475
           QVFW+STGRTYWVHWHMLEILG EE  ED   A   +GA A+ VLG A P+W W PM  L
Sbjct: 411 QVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTEL 470

Query: 476 YPLPYLQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLD-ETLGEKAL 534
           Y +PY+ PE +  E   +LT AEWWELLFFIKKLD  + Q + Q L +NLD E L ++ L
Sbjct: 471 YAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEIL 530

Query: 535 GEISVSVEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDP 594
            E++V +E+A+ LL  L  R   S L DL+N  +Y KYG     P + + ++ +    + 
Sbjct: 531 AELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYG-----PEALAGNQAYPSLLEA 585

Query: 595 EE-----ESKSEASFSEEETESLKAKAEAPKTEAEPT 626
           +E     +++++A  SE   ++ K +A+ P +++  T
Sbjct: 586 QEDVLLLDAQAQAKDSE---DAAKVEAKEPPSQSPNT 619


>gi|5453557 ariadne homolog 2 [Homo sapiens]
          Length = 493

 Score =  177 bits (449), Expect = 1e-43
 Identities = 108/407 (26%), Positives = 181/407 (44%), Gaps = 33/407 (8%)

Query: 2000 QEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLCVHQ 2059
            +E EG + + +  +   L +   VA+ +L + HW   ++L  Y  +   LL+ A +  + 
Sbjct: 67   KESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNP 126

Query: 2060 AQAVPVR--PDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPI 2117
            ++ VP    P HC VC+  +   ++L SL C H  C+SCW ++ +  ++  + +  +C  
Sbjct: 127  SKHVPTSHPPHHCAVCMQFVR-KENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMA 185

Query: 2118 ADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGC 2177
             DCP +    F+  ++ + E+  KY + L R YVES   L  C        I  ++    
Sbjct: 186  QDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRAR 245

Query: 2178 GTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCP 2237
               C++C    CF C     H P  C  + +W+         + ++++ +     +K CP
Sbjct: 246  RVQCNRCNEVFCFKCR-QMYHAPTDCATIRKWLTK------CADDSETANYISAHTKDCP 298

Query: 2238 SCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS-----------AMVSKA 2286
             C   IEKN GC HM C+KC H FCW CL  WK +  +YY CS           +  ++A
Sbjct: 299  KCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQA 358

Query: 2287 ARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPR---------SFTFLNDACQ 2337
                K++  Y ER   H+++ +       R   IHE    R          + +L +A +
Sbjct: 359  REALKKYLFYFERWENHNKSLQLEAQTYQR---IHEKIQERVMNNLGTWIDWQYLQNAAK 415

Query: 2338 GLEQARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLE 2384
             L + R  L Y   Y++Y +      + E Q   LE     L   +E
Sbjct: 416  LLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVE 462


>gi|187761373 ariadne ubiquitin-conjugating enzyme E2 binding protein
            homolog 1 [Homo sapiens]
          Length = 557

 Score =  149 bits (377), Expect = 3e-35
 Identities = 117/453 (25%), Positives = 190/453 (41%), Gaps = 43/453 (9%)

Query: 1997 MSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLC 2056
            ++ +++   M + +R+V E +     + + LL+H +W  E+L++ Y +     L A    
Sbjct: 104  LTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHV 163

Query: 2057 VHQAQAVPVRPDHCPVCVSPLGC--------DDDLPSLCCMHYCCKSCWNEYLTTRI-EQ 2107
            ++ ++    R  +       + C        +     L C H  C  CW+EYLTT+I E+
Sbjct: 164  INPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEE 223

Query: 2108 NLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCD 2167
             +    +CP   C        +  +++  +V  KY+  +   +VE    L WC  P  C 
Sbjct: 224  GMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPD-CH 282

Query: 2168 RILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWV---DDGGYYDGMSVEAQ 2224
             ++  Q         KCG   CFNC     H P  C  + +W+   DD         +++
Sbjct: 283  HVVKVQYPDAKPVRCKCGRQFCFNCG-ENWHDPVKCKWLKKWIKKCDD---------DSE 332

Query: 2225 SKHLAKLISKRCPSCQAPIEKNEGCLHMTCAK--CNHGFCWRCLKSWKPNHKDYYNCSAM 2282
            + +     +K CP C   IEK+ GC HM C    C   FCW CL  W+P+   +YNC+  
Sbjct: 333  TSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRY 392

Query: 2283 ---VSKAAR--QEK------RFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFT- 2330
                +KAAR  QE+      R+  Y  R   H Q+  F   L  +V    E     + + 
Sbjct: 393  NEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSW 452

Query: 2331 ----FLNDACQGLEQARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEET 2386
                FL  A   L Q R  L Y  V++FY +      + E    +LE  T  L   LE  
Sbjct: 453  IEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERD 512

Query: 2387 LLR--CRDLASSLRLLRADCLSTGMELLRRIQE 2417
            + +   +D+   ++     C S    LL+ + E
Sbjct: 513  ISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHE 545


>gi|148596953 ankyrin repeat and IBR domain containing 1 [Homo
            sapiens]
          Length = 1089

 Score =  136 bits (342), Expect = 3e-31
 Identities = 117/497 (23%), Positives = 200/497 (40%), Gaps = 96/497 (19%)

Query: 1997 MSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLC 2056
            + PQ++  L    + +  + L      A+ LL    W  E+LL+++  +PE     +G+ 
Sbjct: 228  LRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSNPENCCQRSGVQ 287

Query: 2057 V--------------------HQAQAVPVRPDH------------CPVCVSPLGCDDDLP 2084
            +                       ++    PD             C +C+  +   +D  
Sbjct: 288  MPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPV 347

Query: 2085 SLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEK 2144
             + C H  C+ CW  +L  +I++    N  CP  DC        I ++VS  E+  +Y +
Sbjct: 348  DMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSK-EMDKRYLQ 406

Query: 2145 ALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTT----------------CSKCGWAS 2188
              ++ +VE+   + WC  P GCDR +     G  T+                C K G   
Sbjct: 407  FDIKAFVENNPAIKWCPTP-GCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGK-GHLF 464

Query: 2189 CFNCSFPEAHYPASCGHMSQW---VDDGGYYDGMSVEAQSKHLAKLI-----SKRCPSCQ 2240
            C+ C   EAH P  C     W   + +    + + V    +  A  +     SK C +C+
Sbjct: 465  CWEC-LGEAHEPCDCQTWKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCK 523

Query: 2241 APIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKD---YYNCS-------------AMVS 2284
            +PI+KNEGC HM CAKC + FCW CL+ WK +      YY C+              M  
Sbjct: 524  SPIQKNEGCNHMQCAKCKYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTV 583

Query: 2285 KAARQEKRFQDYNERCTFHHQAR--EFAVNLRNRV------------SAIHEVPPP-RSF 2329
            +A ++ KRFQ+ +    ++ + +  E +  L  R+             A+ E        
Sbjct: 584  EAEKKHKRFQELDRFMHYYTRFKNHEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDT 643

Query: 2330 TFLNDACQGLEQARKVLAYACVYSFYSQ-DAEYMDVVEQQTENLELHTNALQILLEETLL 2388
            TF+ DA   L + R++L  +  Y F+ +  +   ++ E    +LE+ T  L   +    L
Sbjct: 644  TFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNRPYL 703

Query: 2389 RCRDLASSLRLLRADCL 2405
            R        ++++A CL
Sbjct: 704  R----TPRHKIIKAACL 716


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 52/127 (40%), Positives = 83/127 (65%), Gaps = 2/127 (1%)

Query: 1171 EKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDSSYM 1230
            + + VSS+ ++AS+L D + +  W+S+GS G H+I L +   VLV +L ++V   DSSYM
Sbjct: 2787 KSLNVSSSVNQASRLIDGS-EPCWQSSGSQGKHWIRLEIFPDVLVHRLKMIVDPADSSYM 2845

Query: 1231 PARVVVFGGDSTSCIGTELNTVNVMPSASRVILLENLNRFWPIIQIRIKRCQQGGIDTRV 1290
            P+ VVV GG+S + +  EL T+N+ PS + V LL +   +   I+I IK+C+  GID ++
Sbjct: 2846 PSLVVVSGGNSLNNL-IELKTININPSDTTVPLLNDCTEYHRYIEIAIKQCRSSGIDCKI 2904

Query: 1291 RGVEVLG 1297
             G+ +LG
Sbjct: 2905 HGLILLG 2911



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 11/113 (9%)

Query: 363  FRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGE-FRQSNNGIPP--VQVF 419
            +++R++F S   Y  YV++ +Q GM VR    YEE+  GD G+  +   +G+    VQ  
Sbjct: 2551 YKKRADFLSNDDYAVYVRENIQVGMMVRCCRAYEEVCEGDVGKVIKLDRDGLHDLNVQCD 2610

Query: 420  WQSTGRTYWVHWHMLEILG---PEEATEDKASAAVEKGAGATVLGTAFPSWDW 469
            WQ  G TYWV +  +E++G   P  ++  K    V   A  T      P + W
Sbjct: 2611 WQQKGGTYWVRYIHVELIGYPPPSSSSHIKIGDKVRVKASVTT-----PKYKW 2658


>gi|157738609 HECT domain containing 3 [Homo sapiens]
          Length = 861

 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 52/128 (40%), Positives = 80/128 (62%), Gaps = 5/128 (3%)

Query: 1171 EKVEVSS--NPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDSS 1228
            E ++VSS       S LTD N  TYWES+GS   H++ L M +G +V++L L V + D +
Sbjct: 245  ESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDN 304

Query: 1229 YMPARVVVFGGDSTSCIGTELNTVNVMPS-ASRVILLENLNRFWPIIQIRIKRCQQGGID 1287
            +MP RVVV+GG+  +    +L+ V++  +    V +LE++    PII+IRI  C+  GID
Sbjct: 305  FMPKRVVVYGGEGDNL--KKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGID 362

Query: 1288 TRVRGVEV 1295
             R+RGV++
Sbjct: 363  VRLRGVKI 370


>gi|73747881 zinc finger, ZZ type with EF hand domain 1 [Homo sapiens]
          Length = 2961

 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 52/131 (39%), Positives = 77/131 (58%), Gaps = 2/131 (1%)

Query: 1168 KCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDS 1227
            KC+  +E SSN     K+T+    +YW+S+GS  SH+I L M   V++R L++ VA+ D 
Sbjct: 251  KCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQ 310

Query: 1228 SYMPARVVVFGGDSTSCIGTELNTVNVMPSAS-RVILLENLNRFWPIIQIRIKRCQQGGI 1286
            SYMP +V V  G + S +  E+  V++  + +  V LLEN N     +QI IKRC   G 
Sbjct: 311  SYMPQQVTVAVGRNASDL-QEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGC 369

Query: 1287 DTRVRGVEVLG 1297
            DTR+ G+  +G
Sbjct: 370  DTRIHGLRAVG 380


>gi|34577102 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C +C       + +  L C H  CK+C  +Y   +I    V    CP   CP+  T   +
Sbjct: 220  CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQV 279

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT-TCSKCGWAS 2188
            + +V + E+ ++Y++ LL+  ++  +++ +C  P+ C ++   Q  GC    CS C +A 
Sbjct: 280  KELVEA-ELFARYDRLLLQSSLDLMADVVYC--PRPCCQLPVMQEPGCTMGICSSCNFAF 336

Query: 2189 CFNCSFPEAHYPASCGHMSQWVDD--GGYYDGMSV-------------------EAQSKH 2227
            C  C     H  + C   ++ + D    Y                         E +SK 
Sbjct: 337  CTLCRL-TYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKE 395

Query: 2228 LAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
              +  SK CP C  PIEK +GC  MTC  C   FCW C+ S
Sbjct: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGS 436


>gi|34577100 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C +C       + +  L C H  CK+C  +Y   +I    V    CP   CP+  T   +
Sbjct: 220  CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQV 279

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT-TCSKCGWAS 2188
            + +V + E+ ++Y++ LL+  ++  +++ +C  P+ C ++   Q  GC    CS C +A 
Sbjct: 280  KELVEA-ELFARYDRLLLQSSLDLMADVVYC--PRPCCQLPVMQEPGCTMGICSSCNFAF 336

Query: 2189 CFNCSFPEAHYPASCGHMSQWVDD--GGYYDGMSV-------------------EAQSKH 2227
            C  C     H  + C   ++ + D    Y                         E +SK 
Sbjct: 337  CTLCRL-TYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKE 395

Query: 2228 LAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
              +  SK CP C  PIEK +GC  MTC  C   FCW C+ S
Sbjct: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGS 436


>gi|34577098 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C +C       + +  L C H  CK+C  +Y   +I    V    CP   CP+  T   +
Sbjct: 220  CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQV 279

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT-TCSKCGWAS 2188
            + +V + E+ ++Y++ LL+  ++  +++ +C  P+ C ++   Q  GC    CS C +A 
Sbjct: 280  KELVEA-ELFARYDRLLLQSSLDLMADVVYC--PRPCCQLPVMQEPGCTMGICSSCNFAF 336

Query: 2189 CFNCSFPEAHYPASCGHMSQWVDD--GGYYDGMSV-------------------EAQSKH 2227
            C  C     H  + C   ++ + D    Y                         E +SK 
Sbjct: 337  CTLCRL-TYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKE 395

Query: 2228 LAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
              +  SK CP C  PIEK +GC  MTC  C   FCW C+ S
Sbjct: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGS 436


>gi|34577096 ring finger protein 14 isoform 2 [Homo sapiens]
          Length = 348

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C +C       + +  L C H  CK+C  +Y   +I    V    CP   CP+  T   +
Sbjct: 94   CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQV 153

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT-TCSKCGWAS 2188
            + +V + E+ ++Y++ LL+  ++  +++ +C  P+ C ++   Q  GC    CS C +A 
Sbjct: 154  KELVEA-ELFARYDRLLLQSSLDLMADVVYC--PRPCCQLPVMQEPGCTMGICSSCNFAF 210

Query: 2189 CFNCSFPEAHYPASCGHMSQWVDD--GGYYDGMSV-------------------EAQSKH 2227
            C  C     H  + C   ++ + D    Y                         E +SK 
Sbjct: 211  CTLCRL-TYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKE 269

Query: 2228 LAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
              +  SK CP C  PIEK +GC  MTC  C   FCW C+ S
Sbjct: 270  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGS 310


>gi|4757762 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 60/221 (27%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C +C       + +  L C H  CK+C  +Y   +I    V    CP   CP+  T   +
Sbjct: 220  CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQV 279

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT-TCSKCGWAS 2188
            + +V + E+ ++Y++ LL+  ++  +++ +C  P+ C ++   Q  GC    CS C +A 
Sbjct: 280  KELVEA-ELFARYDRLLLQSSLDLMADVVYC--PRPCCQLPVMQEPGCTMGICSSCNFAF 336

Query: 2189 CFNCSFPEAHYPASCGHMSQWVDD--GGYYDGMSV-------------------EAQSKH 2227
            C  C     H  + C   ++ + D    Y                         E +SK 
Sbjct: 337  CTLCRL-TYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKE 395

Query: 2228 LAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
              +  SK CP C  PIEK +GC  MTC  C   FCW C+ S
Sbjct: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGS 436


>gi|188219579 ring finger protein 19B isoform b [Homo sapiens]
          Length = 587

 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 63/217 (29%), Positives = 94/217 (43%), Gaps = 23/217 (10%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            CP+C+  L  +     L C H  C+ C   YL   I ++ V   +CP  +C  +     I
Sbjct: 119  CPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRV-PISCP--ECSERLNPHDI 175

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASC 2189
            R +++ P ++ KYE+ +LR Y+ S  +  WC  P  C   +   G      C+ C   +C
Sbjct: 176  RLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPD-CGYAVIAYG------CASCPKLTC 228

Query: 2190 FN--CSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLIS---------KRCPS 2238
                C     ++     H +Q  D        ++  ++KH + L           K CP 
Sbjct: 229  EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPDDIKPCPR 288

Query: 2239 CQAPIEK-NEG-CLHMTCAKCNHGFCWRCLKSWKPNH 2273
            C A I K N+G C HMTCA C   FCW C+K     H
Sbjct: 289  CSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 325


>gi|188219577 ring finger protein 19B isoform a [Homo sapiens]
          Length = 732

 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 63/218 (28%), Positives = 94/218 (43%), Gaps = 24/218 (11%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            CP+C+  L  +     L C H  C+ C   YL   I ++ V   +CP  +C  +     I
Sbjct: 119  CPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRV-PISCP--ECSERLNPHDI 175

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASC 2189
            R +++ P ++ KYE+ +LR Y+ S  +  WC  P  C   +   G      C+ C   +C
Sbjct: 176  RLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPD-CGYAVIAYG------CASCPKLTC 228

Query: 2190 FN--CSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLIS----------KRCP 2237
                C     ++     H +Q  D        ++  ++KH + L            K CP
Sbjct: 229  EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCP 288

Query: 2238 SCQAPIEK-NEG-CLHMTCAKCNHGFCWRCLKSWKPNH 2273
             C A I K N+G C HMTCA C   FCW C+K     H
Sbjct: 289  RCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 326


>gi|35493801 ring finger protein 19 [Homo sapiens]
          Length = 838

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 63/215 (29%), Positives = 93/215 (43%), Gaps = 17/215 (7%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            CP+C+     D     + C H  C  C  +YL   I ++ V N +CP  +C  +     I
Sbjct: 132  CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRV-NISCP--ECTERFNPHDI 188

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT----TCSK-- 2183
            R I+S   ++ KYE+ +LR ++ +  +  WC  P     ++     GC +    TC +  
Sbjct: 189  RLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIA---FGCASCPKLTCGREG 245

Query: 2184 CGWASCFNCS---FPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQ 2240
            CG   C++C     P     A+    +Q +            +Q    A    K CP C 
Sbjct: 246  CGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCA 305

Query: 2241 APIEK-NEG-CLHMTCAKCNHGFCWRCLKSWKPNH 2273
            A I K N+G C HMTCA C   FCW C+K     H
Sbjct: 306  AYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 340


>gi|35493782 ring finger protein 19 [Homo sapiens]
          Length = 838

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 63/215 (29%), Positives = 93/215 (43%), Gaps = 17/215 (7%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            CP+C+     D     + C H  C  C  +YL   I ++ V N +CP  +C  +     I
Sbjct: 132  CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRV-NISCP--ECTERFNPHDI 188

Query: 2130 RAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT----TCSK-- 2183
            R I+S   ++ KYE+ +LR ++ +  +  WC  P     ++     GC +    TC +  
Sbjct: 189  RLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIA---FGCASCPKLTCGREG 245

Query: 2184 CGWASCFNCS---FPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQ 2240
            CG   C++C     P     A+    +Q +            +Q    A    K CP C 
Sbjct: 246  CGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCA 305

Query: 2241 APIEK-NEG-CLHMTCAKCNHGFCWRCLKSWKPNH 2273
            A I K N+G C HMTCA C   FCW C+K     H
Sbjct: 306  AYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 340


>gi|38045938 ring finger protein 144 [Homo sapiens]
          Length = 292

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 55/205 (26%), Positives = 78/205 (38%), Gaps = 13/205 (6%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQP--TGA 2127
            C +C+     +       C    C  C  +Y+   I++ L    +CP A CP Q      
Sbjct: 20   CKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQEN 79

Query: 2128 FIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTT----CSK 2183
             I  +V++ E++ +Y+K      V      TWC     C  +   Q +G  T     C  
Sbjct: 80   EIECMVAA-EIMQRYKKLQFEREVLFDPCRTWCP-ASTCQAVCQLQDVGLQTPQPVQCKA 137

Query: 2184 CGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPI 2243
            C    C  C     H    C           +  G +  A          KRCP C+  I
Sbjct: 138  CRMEFCSTCK-ASWHPGQGCPETMPIT----FLPGETSAAFKMEEDDAPIKRCPKCKVYI 192

Query: 2244 EKNEGCLHMTCAKCNHGFCWRCLKS 2268
            E++EGC  M C  C H FCW CL+S
Sbjct: 193  ERDEGCAQMMCKNCKHAFCWYCLES 217


>gi|169790973 parkin isoform 3 [Homo sapiens]
          Length = 316

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 54/207 (26%), Positives = 80/207 (38%), Gaps = 37/207 (17%)

Query: 2090 HYCCKSCWNEYLTTRI-------EQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKY 2142
            H  C  C++ Y  TR+       +  L  +  C +A CP           +   E  ++Y
Sbjct: 108  HVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPC-VAGCPNSLIKELHHFRILGEEQYNRY 166

Query: 2143 EKALLRGYVESCSNLTWCTNPQGCD----------RILCRQGLGCGTTCSKCGWASCFNC 2192
            ++      V     +  C  P GC           ++ C  G G G     CG+A C  C
Sbjct: 167  QQYGAEECVLQMGGVL-CPRP-GCGAGLLPEPDQRKVTCEGGNGLG-----CGFAFCREC 219

Query: 2193 SFPEAHYPASCGHMSQ--------WVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIE 2244
               EA++   C  + +        +  D    +    EA SK   K  +K CP C  P+E
Sbjct: 220  K--EAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVE 277

Query: 2245 KNEGCLHMTC--AKCNHGFCWRCLKSW 2269
            KN GC+HM C   +C   +CW C   W
Sbjct: 278  KNGGCMHMKCPQPQCRLEWCWNCGCEW 304


>gi|169790971 parkin isoform 2 [Homo sapiens]
          Length = 437

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 54/207 (26%), Positives = 80/207 (38%), Gaps = 37/207 (17%)

Query: 2090 HYCCKSCWNEYLTTRI-------EQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKY 2142
            H  C  C++ Y  TR+       +  L  +  C +A CP           +   E  ++Y
Sbjct: 229  HVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPC-VAGCPNSLIKELHHFRILGEEQYNRY 287

Query: 2143 EKALLRGYVESCSNLTWCTNPQGCD----------RILCRQGLGCGTTCSKCGWASCFNC 2192
            ++      V     +  C  P GC           ++ C  G G G     CG+A C  C
Sbjct: 288  QQYGAEECVLQMGGVL-CPRP-GCGAGLLPEPDQRKVTCEGGNGLG-----CGFAFCREC 340

Query: 2193 SFPEAHYPASCGHMSQ--------WVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIE 2244
               EA++   C  + +        +  D    +    EA SK   K  +K CP C  P+E
Sbjct: 341  K--EAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVE 398

Query: 2245 KNEGCLHMTC--AKCNHGFCWRCLKSW 2269
            KN GC+HM C   +C   +CW C   W
Sbjct: 399  KNGGCMHMKCPQPQCRLEWCWNCGCEW 425


>gi|169790969 parkin isoform 1 [Homo sapiens]
          Length = 465

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 54/207 (26%), Positives = 80/207 (38%), Gaps = 37/207 (17%)

Query: 2090 HYCCKSCWNEYLTTRI-------EQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKY 2142
            H  C  C++ Y  TR+       +  L  +  C +A CP           +   E  ++Y
Sbjct: 257  HVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPC-VAGCPNSLIKELHHFRILGEEQYNRY 315

Query: 2143 EKALLRGYVESCSNLTWCTNPQGCD----------RILCRQGLGCGTTCSKCGWASCFNC 2192
            ++      V     +  C  P GC           ++ C  G G G     CG+A C  C
Sbjct: 316  QQYGAEECVLQMGGVL-CPRP-GCGAGLLPEPDQRKVTCEGGNGLG-----CGFAFCREC 368

Query: 2193 SFPEAHYPASCGHMSQ--------WVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIE 2244
               EA++   C  + +        +  D    +    EA SK   K  +K CP C  P+E
Sbjct: 369  K--EAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVE 426

Query: 2245 KNEGCLHMTC--AKCNHGFCWRCLKSW 2269
            KN GC+HM C   +C   +CW C   W
Sbjct: 427  KNGGCMHMKCPQPQCRLEWCWNCGCEW 453


>gi|50284696 IBR domain containing 2 [Homo sapiens]
          Length = 303

 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 52/211 (24%), Positives = 76/211 (36%), Gaps = 27/211 (12%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYC----CKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPT 2125
            C +C+    C+  L  +  +  C    C +C  +Y+   I +      TCP   C    T
Sbjct: 30   CKLCL----CEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGT 85

Query: 2126 --GAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSK 2183
               A I  +V   +    Y++      V      TWC     C  +       C    S 
Sbjct: 86   LQEAEIACLVPVDQ-FQLYQRLKFEREVHLDPYRTWCPVAD-CQTV-------CPVASSD 136

Query: 2184 CGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLIS------KRCP 2237
             G      C  P  H          W  +    D   +   ++H A   +      K+CP
Sbjct: 137  PGQPVLVEC--PSCHLKFCSCCKDAWHAEVSCRDSQPIVLPTEHRALFGTDAEAPIKQCP 194

Query: 2238 SCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2268
             C+  IE+NEGC  M C  C H FCW CL++
Sbjct: 195  VCRVYIERNEGCAQMMCKNCKHTFCWYCLQN 225


>gi|109150431 ring finger protein 31 [Homo sapiens]
          Length = 1072

 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 47/223 (21%), Positives = 78/223 (34%), Gaps = 29/223 (13%)

Query: 2070 CPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFI 2129
            C VC   L  +       C    C  C+ ++ T  +++  + +  CP    P       +
Sbjct: 699  CAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQL 758

Query: 2130 RAIVSS----------PEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGT 2179
             +  S+          P+  + + K L  G +       WC     C      +      
Sbjct: 759  LSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQ---CSFGFIYEREQLEA 815

Query: 2180 TCSKCGWASCFNCS--FPEAHYPASCGHMSQW--VDDGGYYDGMSVEAQSKHLAKLISKR 2235
            TC +C    C  C   + E H   SC     W  ++D  Y        Q++ LA  + + 
Sbjct: 816  TCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEY--------QAQGLAMYLQEN 867

Query: 2236 ---CPSCQAPIE-KNEGCLHMTCAKCNHGFCWRCLKSWKPNHK 2274
               CP C+        GC+H  C +C H FC  C  ++   +K
Sbjct: 868  GIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNK 910



 Score = 35.0 bits (79), Expect = 0.93
 Identities = 27/125 (21%), Positives = 45/125 (36%), Gaps = 16/125 (12%)

Query: 2236 CPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCSAMVSKAARQEKRFQD 2295
            C  C          L  TC +C+  FC RC + W+  H+             R  + FQ+
Sbjct: 799  CAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHR------------GRSCEDFQN 846

Query: 2296 YNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLE--QARKVLAYACVYS 2353
            +       +QA+  A+ L+   + I       S+      C      Q R      C  +
Sbjct: 847  WKRMNDPEYQAQGLAMYLQE--NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNA 904

Query: 2354 FYSQD 2358
            FY+++
Sbjct: 905  FYAKN 909


>gi|115529449 upstream binding transcription factor, RNA polymerase I
            isoform b [Homo sapiens]
          Length = 727

 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 28/73 (38%), Positives = 43/73 (58%)

Query: 2445 KGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFF 2504
            +GPN   S+    S  E+EE++E+DEDD  E +++E DE  D+     D SE+  ++   
Sbjct: 623  RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESE 682

Query: 2505 FGDEEEDEDEAYD 2517
             GDE E++DE  D
Sbjct: 683  DGDENEEDDEDED 695



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 20/71 (28%), Positives = 35/71 (49%)

Query: 2443 EAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQET 2502
            ++K  +    +       E EEEE+D+  D  E   D  +   +++S   DE+E  D++ 
Sbjct: 635  QSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDE 694

Query: 2503 FFFGDEEEDED 2513
                D++EDED
Sbjct: 695  DDDEDDDEDED 705



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 15/39 (38%), Positives = 26/39 (66%)

Query: 2451 GSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDS 2489
            G   ++SS  E+E+ +E++EDD  E   ++ DE+ DN+S
Sbjct: 670  GDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 708



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 15/48 (31%), Positives = 29/48 (60%), Gaps = 4/48 (8%)

Query: 2452 SQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLD 2499
            S+ ++  G E EE++ED++DD    + D+ DE+ +++  S   S + D
Sbjct: 677  SEDESEDGDENEEDDEDEDDD----EDDDEDEDNESEGSSSSSSSSGD 720


>gi|115529451 upstream binding transcription factor, RNA polymerase I
            isoform b [Homo sapiens]
          Length = 727

 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 28/73 (38%), Positives = 43/73 (58%)

Query: 2445 KGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFF 2504
            +GPN   S+    S  E+EE++E+DEDD  E +++E DE  D+     D SE+  ++   
Sbjct: 623  RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESE 682

Query: 2505 FGDEEEDEDEAYD 2517
             GDE E++DE  D
Sbjct: 683  DGDENEEDDEDED 695



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 20/71 (28%), Positives = 35/71 (49%)

Query: 2443 EAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQET 2502
            ++K  +    +       E EEEE+D+  D  E   D  +   +++S   DE+E  D++ 
Sbjct: 635  QSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDE 694

Query: 2503 FFFGDEEEDED 2513
                D++EDED
Sbjct: 695  DDDEDDDEDED 705



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 15/39 (38%), Positives = 26/39 (66%)

Query: 2451 GSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDS 2489
            G   ++SS  E+E+ +E++EDD  E   ++ DE+ DN+S
Sbjct: 670  GDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 708



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 15/48 (31%), Positives = 29/48 (60%), Gaps = 4/48 (8%)

Query: 2452 SQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLD 2499
            S+ ++  G E EE++ED++DD    + D+ DE+ +++  S   S + D
Sbjct: 677  SEDESEDGDENEEDDEDEDDD----EDDDEDEDNESEGSSSSSSSSGD 720


>gi|7657671 upstream binding transcription factor, RNA polymerase I
            isoform a [Homo sapiens]
          Length = 764

 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 28/73 (38%), Positives = 43/73 (58%)

Query: 2445 KGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFF 2504
            +GPN   S+    S  E+EE++E+DEDD  E +++E DE  D+     D SE+  ++   
Sbjct: 660  RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESE 719

Query: 2505 FGDEEEDEDEAYD 2517
             GDE E++DE  D
Sbjct: 720  DGDENEEDDEDED 732



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 20/71 (28%), Positives = 35/71 (49%)

Query: 2443 EAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQET 2502
            ++K  +    +       E EEEE+D+  D  E   D  +   +++S   DE+E  D++ 
Sbjct: 672  QSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDE 731

Query: 2503 FFFGDEEEDED 2513
                D++EDED
Sbjct: 732  DDDEDDDEDED 742



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 15/39 (38%), Positives = 26/39 (66%)

Query: 2451 GSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDS 2489
            G   ++SS  E+E+ +E++EDD  E   ++ DE+ DN+S
Sbjct: 707  GDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 745



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 15/48 (31%), Positives = 29/48 (60%), Gaps = 4/48 (8%)

Query: 2452 SQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLD 2499
            S+ ++  G E EE++ED++DD    + D+ DE+ +++  S   S + D
Sbjct: 714  SEDESEDGDENEEDDEDEDDD----EDDDEDEDNESEGSSSSSSSSGD 757


>gi|5454168 RanBP-type and C3HC4-type zinc finger containing 1 isoform
            1 [Homo sapiens]
          Length = 468

 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 46/211 (21%), Positives = 77/211 (36%), Gaps = 29/211 (13%)

Query: 2067 PDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTG 2126
            P  CPVC S L   + +    C+H  C+ C    L   I  +     +CP  D     +G
Sbjct: 237  PAECPVCYSVLAPGEAVVLRECLHTFCREC----LQGTIRNSQEAEVSCPFIDNTYSCSG 292

Query: 2127 AFIRAIVSSPEVISKYEKALLRGY--VESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKC 2184
              +   + +      Y++ L  G    E+ S  ++      C      +      TC  C
Sbjct: 293  KLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVC 352

Query: 2185 GWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISK---------- 2234
               +C  C     H   +C           Y + +++ AQ+   A+  ++          
Sbjct: 353  FHVNCLLCK--AIHEQMNCKE---------YQEDLALRAQNDVAARQTTEMLKVMLQQGE 401

Query: 2235 --RCPSCQAPIEKNEGCLHMTCAKCNHGFCW 2263
              RCP CQ  ++K +GC  + C  C+   CW
Sbjct: 402  AMRCPQCQIVVQKKDGCDWIRCTVCHTEICW 432


>gi|144953898 RanBP-type and C3HC4-type zinc finger containing 1
            isoform 2 [Homo sapiens]
          Length = 510

 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 46/211 (21%), Positives = 77/211 (36%), Gaps = 29/211 (13%)

Query: 2067 PDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTG 2126
            P  CPVC S L   + +    C+H  C+ C    L   I  +     +CP  D     +G
Sbjct: 279  PAECPVCYSVLAPGEAVVLRECLHTFCREC----LQGTIRNSQEAEVSCPFIDNTYSCSG 334

Query: 2127 AFIRAIVSSPEVISKYEKALLRGY--VESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKC 2184
              +   + +      Y++ L  G    E+ S  ++      C      +      TC  C
Sbjct: 335  KLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVC 394

Query: 2185 GWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISK---------- 2234
               +C  C     H   +C           Y + +++ AQ+   A+  ++          
Sbjct: 395  FHVNCLLCK--AIHEQMNCKE---------YQEDLALRAQNDVAARQTTEMLKVMLQQGE 443

Query: 2235 --RCPSCQAPIEKNEGCLHMTCAKCNHGFCW 2263
              RCP CQ  ++K +GC  + C  C+   CW
Sbjct: 444  AMRCPQCQIVVQKKDGCDWIRCTVCHTEICW 474


>gi|22749145 ring finger protein 217 [Homo sapiens]
          Length = 275

 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 7/85 (8%)

Query: 2181 CSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQ 2240
            C  C +  CF C  P  H   +C    +  D    +    +E   ++     +++CP C+
Sbjct: 83   CPTCQFVWCFKCHSPW-HEGVNCKEYKKG-DKLLRHWASEIEHGQRN-----AQKCPKCK 135

Query: 2241 APIEKNEGCLHMTCAKCNHGFCWRC 2265
              I++ EGC HMTC++CN  FC+RC
Sbjct: 136  IHIQRTEGCDHMTCSQCNTNFCYRC 160


>gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein [Homo
            sapiens]
          Length = 593

 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 30/80 (37%), Positives = 41/80 (51%), Gaps = 11/80 (13%)

Query: 2437 PSVEAWEAKGPNMPGSQPQASSGPEAEEEEE--DDEDDVPEWQQDEFDEELDNDSFSYDE 2494
            P  E  +A     PGS  +   GP  E  E+   DED  P+W+++E +E+L  D    +E
Sbjct: 86   PGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGED----EE 141

Query: 2495 SENLDQETFFFGDEEEDEDE 2514
             E  D E     DEEE+EDE
Sbjct: 142  EEEEDYE-----DEEEEEDE 156



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 22/48 (45%), Positives = 27/48 (56%), Gaps = 5/48 (10%)

Query: 1661 EQEDEEEKRLEEEEEEEE----EEEAEKELFIEDPSPA-ISILVLSPR 1703
            E+E+ EE   E+EEEEEE    EEE E E  +  P PA +    L PR
Sbjct: 128  EEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPR 175


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,298,482
Number of Sequences: 37866
Number of extensions: 5452492
Number of successful extensions: 55283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 39257
Number of HSP's gapped (non-prelim): 11232
length of query: 2517
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2398
effective length of database: 13,741,464
effective search space: 32952030672
effective search space used: 32952030672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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