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Search of human proteins with 242247193
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 1372 0.0
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 386 e-107
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 368 e-101
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 368 e-101
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 368 e-101
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 368 e-101
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 264 2e-70
gi|187475373 c-src tyrosine kinase [Homo sapiens] 59 2e-08
gi|4758078 c-src tyrosine kinase [Homo sapiens] 59 2e-08
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 59 2e-08
gi|169790811 SHC (Src homology 2 domain containing) transforming... 59 2e-08
gi|222446609 rai-like protein [Homo sapiens] 58 3e-08
gi|194239668 SHC (Src homology 2 domain containing) transforming... 58 3e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming... 58 3e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming... 58 3e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 58 3e-08
gi|224586793 src homology 2 domain-containing transforming prote... 55 2e-07
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 55 2e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 54 4e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 54 4e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 54 4e-07
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 53 1e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 52 2e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 52 2e-06
gi|222537752 Src homology 2 domain containing transforming prote... 52 2e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 51 3e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 51 3e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 51 3e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 51 3e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 51 3e-06
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 1372 bits (3552), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MDPSYCPAHGFPSQDPLWPLSSQQWSSAHYSEPAAGGCDGTEAMNGAGPGPAAAAPVPVP 60
MDPSYCPAHGFPSQDPLWPLSSQQWSSAHYSEPAAGGCDGTEAMNGAGPGPAAAAPVPVP
Sbjct: 1 MDPSYCPAHGFPSQDPLWPLSSQQWSSAHYSEPAAGGCDGTEAMNGAGPGPAAAAPVPVP 60
Query: 61 VPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEV 120
VPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEV
Sbjct: 61 VPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEV 120
Query: 121 RRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSL 180
RRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSL
Sbjct: 121 RRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSL 180
Query: 181 RNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQRE 240
RNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQRE
Sbjct: 181 RNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQRE 240
Query: 241 GALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAII 300
GALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAII
Sbjct: 241 GALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAII 300
Query: 301 EVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELS 360
EVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELS
Sbjct: 301 EVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELS 360
Query: 361 CTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLET 420
CTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLET
Sbjct: 361 CTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLET 420
Query: 421 FLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPR 480
FLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPR
Sbjct: 421 FLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPR 480
Query: 481 NHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTH 540
NHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTH
Sbjct: 481 NHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTH 540
Query: 541 PIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPP 600
PIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPP
Sbjct: 541 PIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPP 600
Query: 601 ASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEA 660
ASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEA
Sbjct: 601 ASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEA 660
Query: 661 APGRARAVENQYSFY 675
APGRARAVENQYSFY
Sbjct: 661 APGRARAVENQYSFY 675
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 386 bits (991), Expect = e-107
Identities = 288/760 (37%), Positives = 372/760 (48%), Gaps = 134/760 (17%)
Query: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
Query: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
++A P P ++WT R LRLSR A
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
Query: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
Query: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
Query: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
P E+ A G A + A H + + L +P+E
Sbjct: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
Query: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 533 MLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPT-PPAAPASPACWSDSPGQHYFS 591
ML HF HPIPLESGGS+D+ L SYV + EP + P P P W+D P
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSHDPPQPPEPPSWTDPPQ----P 655
Query: 592 SLAAAACPPASPSDAAGASSSSASSSSAASGPAPPR--PVEGQLSARSRSNSAERLLEAV 649
A+ P + AA A+ A G P PV + + EA
Sbjct: 656 GAEEASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQ 715
Query: 650 AATA---AEEPP----EAAP--------GRARAVENQYSF 674
A + A PP + +P G RA+ NQYSF
Sbjct: 716 GAGSGGDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQYSF 755
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 368 bits (944), Expect = e-101
Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)
Query: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
Query: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
++A P P ++WT R LRLSR A
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
Query: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
Query: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
Query: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
P E+ A G A + A H + + L +P+E
Sbjct: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
Query: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 533 MLRHFHTHPIPLESGGSADITLRSYV 558
ML HF HPIPLESGGS+D+ L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 368 bits (944), Expect = e-101
Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)
Query: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
Query: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
++A P P ++WT R LRLSR A
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
Query: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
Query: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
Query: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
P E+ A G A + A H + + L +P+E
Sbjct: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
Query: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 533 MLRHFHTHPIPLESGGSADITLRSYV 558
ML HF HPIPLESGGS+D+ L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 368 bits (944), Expect = e-101
Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)
Query: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
Query: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
++A P P ++WT R LRLSR A
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
Query: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
Query: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
Query: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
P E+ A G A + A H + + L +P+E
Sbjct: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
Query: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 533 MLRHFHTHPIPLESGGSADITLRSYV 558
ML HF HPIPLESGGS+D+ L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 368 bits (944), Expect = e-101
Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)
Query: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
Query: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
++A P P ++WT R LRLSR A
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
Query: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
Query: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
Query: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
P E+ A G A + A H + + L +P+E
Sbjct: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
Query: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 533 MLRHFHTHPIPLESGGSADITLRSYV 558
ML HF HPIPLESGGS+D+ L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 264 bits (675), Expect = 2e-70
Identities = 229/657 (34%), Positives = 297/657 (45%), Gaps = 111/657 (16%)
Query: 44 MNGAG--PGPAAAAPVPVPVPVP-DWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
MNG P ++AP P P W +FCELHA AAA + A ++ F R++P + P
Sbjct: 1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR 59
Query: 101 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG 156
S F F F EVR G T RG AEA PE A P
Sbjct: 60 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP-- 116
Query: 157 HSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRAS---PEPDAAAAPRTAE 213
+RSSE++ A + F SL R ++ RR++ P AAAP T
Sbjct: 117 KARSSEEL---APPRPPGPCSFQHFRRSL------RHIFRRRSAGELPAAHTAAAPGTPG 167
Query: 214 PRDKWTRRLRLSRTLA----AKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLR 269
+ R L++ A+ + +E LR+ +AD+A+ SG A+WQ+ RL LR
Sbjct: 168 EAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSG--ARWQRGRLALR 225
Query: 270 RAVAEERFR--LEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEY 327
RA + LE F PPK+SRPK+ S+I EVR LEMP+ TFVLKV++ +
Sbjct: 226 RAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDI 285
Query: 328 ILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPR 387
I E D Q +SW+A++ CT G
Sbjct: 286 IFEVGDEQQLNSWMAELS--------------ECTGRGL--------------------- 310
Query: 388 PPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDP 447
E+T E+ +H+P T SP GS N G DP
Sbjct: 311 --EST------------------EAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDP 350
Query: 448 EAEP-ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
+ + LS YPWFHG +SRVKAAQLV GP HG+F++RQSETR GEYVLTFNFQG
Sbjct: 351 ACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGI 410
Query: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPE 566
AKHLRLSL GQC VQHL F SV+DML HF PIPLE G + D+ L SYV PP
Sbjct: 411 AKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPG 470
Query: 567 PGPTPPAAPASPACWSDSPGQHYFSS-----LAAAACPPA-SPSDAAGASSSSASSSSAA 620
T P S W H+ S L+++ CP SP G SS
Sbjct: 471 SCNT-VLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS--------- 520
Query: 621 SGPAPPRPVEGQL-SARSRSNSAERLLEAVAATAAE---EPPEAAPGRARAVENQYS 673
PP + + S +NS + L A + E ++ RA++NQY+
Sbjct: 521 ----PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYT 573
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 58.5 bits (140), Expect = 2e-08
Identities = 26/84 (30%), Positives = 50/84 (59%), Gaps = 3/84 (3%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+LS PWFHG ++R +A +L+ P GLF++R+S PG+Y L + GK +H R+
Sbjct: 76 KLSLMPWFHGKITREQAERLLY---PPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIM 132
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHF 537
+ + ++F++++ ++ H+
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 58.5 bits (140), Expect = 2e-08
Identities = 26/84 (30%), Positives = 50/84 (59%), Gaps = 3/84 (3%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+LS PWFHG ++R +A +L+ P GLF++R+S PG+Y L + GK +H R+
Sbjct: 76 KLSLMPWFHGKITREQAERLLY---PPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIM 132
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHF 537
+ + ++F++++ ++ H+
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHY 156
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/112 (33%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 447 PEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
P A E +L PW+HG +SR A +++ A G F++R S T PG+YVLT G+
Sbjct: 367 PVAPTEEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQ 421
Query: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYV 558
KHL L ++ G + + F+S+ ++ H + P+ + S ++ LR V
Sbjct: 422 PKHL-LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES-ELHLRGVV 471
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/112 (33%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 447 PEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
P A E +L PW+HG +SR A +++ A G F++R S T PG+YVLT G+
Sbjct: 474 PVAPTEEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQ 528
Query: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYV 558
KHL L ++ G + + F+S+ ++ H + P+ + S ++ LR V
Sbjct: 529 PKHL-LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES-ELHLRGVV 578
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 57.8 bits (138), Expect = 3e-08
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 13/147 (8%)
Query: 423 QTLESPGGSGSDSNNTGEQGAETDPEAEPEL-----ELSDYPWFHGTLSRVKAAQLVLAG 477
Q L SP G + T + GA P + L +L +HG LSR A L++
Sbjct: 485 QPLGSPWHCGK-APETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKD 543
Query: 478 GPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHF 537
G F++R+S T PG+YVL+ G+AKHL L ++ G+ + F +V ++R+
Sbjct: 544 GD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLIRYH 597
Query: 538 HTHPIPLESGGSADITLRSYVRAQDPP 564
+ +P+ S GS +++L+ VR + P
Sbjct: 598 MDNSLPIISSGS-EVSLKQPVRKDNNP 623
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+L PWFHG LSR +A L+ G F++R+S T PG+YVLT G+ KHL L
Sbjct: 372 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 425
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
++ G + F+SV ++ + + +P+ S GS
Sbjct: 426 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+L PWFHG LSR +A L+ G F++R+S T PG+YVLT G+ KHL L
Sbjct: 483 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 536
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
++ G + F+SV ++ + + +P+ S GS
Sbjct: 537 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+L PWFHG LSR +A L+ G F++R+S T PG+YVLT G+ KHL L
Sbjct: 482 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 535
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
++ G + F+SV ++ + + +P+ S GS
Sbjct: 536 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
+L PWFHG LSR +A L+ G F++R+S T PG+YVLT G+ KHL L
Sbjct: 373 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 426
Query: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
++ G + F+SV ++ + + +P+ S GS
Sbjct: 427 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 462
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 6/103 (5%)
Query: 447 PEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
P+A+ EL W+ G +SR +A L+ G F++R+S T PG +VLT G+
Sbjct: 486 PDAKMLEELQAETWYQGEMSRKEAEGLL-----EKDGDFLVRKSTTNPGSFVLTGMHNGQ 540
Query: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
AKHL L ++ G + F S+ ++ H +P+ S GS
Sbjct: 541 AKHL-LLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/107 (36%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 422 LQTLESPGGSGSDSNNTGEQGAETDP-----EAEPELELSDYPWFHGTLSRVKAAQLVLA 476
L LE GG +G+ A P +A PE LSD PW+ +SR +A QL+L+
Sbjct: 78 LCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET-LSDQPWYFSGVSRTQAQQLLLS 136
Query: 477 GGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ 523
P G F+IR SE+ G Y L+ Q K H R+S+ G ++Q
Sbjct: 137 P-PNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQ 182
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/90 (36%), Positives = 52/90 (57%), Gaps = 7/90 (7%)
Query: 449 AEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAK 508
A+P+L L PWFHG +S +A Q + P GLF++R+S PG+YVL +F
Sbjct: 72 ADPKLSLM--PWFHGKISGQEAVQQLQ---PPEDGLFLVRESARHPGDYVLCVSFGRDVI 126
Query: 509 HLR-LSLNGHGQCHVQHLWFQSVLDMLRHF 537
H R L +GH + ++F +++DM+ H+
Sbjct: 127 HYRVLHRDGHLTID-EAVFFCNLMDMVEHY 155
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/90 (36%), Positives = 52/90 (57%), Gaps = 7/90 (7%)
Query: 449 AEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAK 508
A+P+L L PWFHG +S +A Q + P GLF++R+S PG+YVL +F
Sbjct: 114 ADPKLSLM--PWFHGKISGQEAVQQLQ---PPEDGLFLVRESARHPGDYVLCVSFGRDVI 168
Query: 509 HLR-LSLNGHGQCHVQHLWFQSVLDMLRHF 537
H R L +GH + ++F +++DM+ H+
Sbjct: 169 HYRVLHRDGHLTID-EAVFFCNLMDMVEHY 197
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/90 (36%), Positives = 52/90 (57%), Gaps = 7/90 (7%)
Query: 449 AEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAK 508
A+P+L L PWFHG +S +A Q + P GLF++R+S PG+YVL +F
Sbjct: 113 ADPKLSLM--PWFHGKISGQEAVQQLQ---PPEDGLFLVRESARHPGDYVLCVSFGRDVI 167
Query: 509 HLR-LSLNGHGQCHVQHLWFQSVLDMLRHF 537
H R L +GH + ++F +++DM+ H+
Sbjct: 168 HYRVLHRDGHLTID-EAVFFCNLMDMVEHY 196
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 52.8 bits (125), Expect = 1e-06
Identities = 24/82 (29%), Positives = 49/82 (59%), Gaps = 2/82 (2%)
Query: 453 LELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRL 512
+E+ +PWF G + R KA +++ R+ G F+IR+SE+ PG++ L+ F +H ++
Sbjct: 53 IEMKPHPWFFGKIPRAKAEEML--SKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110
Query: 513 SLNGHGQCHVQHLWFQSVLDML 534
+G G+ + + F S+ +++
Sbjct: 111 LRDGAGKYFLWVVKFNSLNELV 132
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 4/111 (3%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G ++ QG P L + W+HG +SR AA+ +L+ G +G F++R+
Sbjct: 97 GEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-NAAEYLLSSGI--NGSFLVRE 153
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHV-QHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V F ++ +++ H T
Sbjct: 154 SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 4/111 (3%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G ++ QG P L + W+HG +SR AA+ +L+ G +G F++R+
Sbjct: 116 GEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-NAAEYLLSSGI--NGSFLVRE 172
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHV-QHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V F ++ +++ H T
Sbjct: 173 SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHST 223
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 51.6 bits (122), Expect = 2e-06
Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 7/140 (5%)
Query: 426 ESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLF 485
E GS + + + +P L L PWFHG L+R A L+ G +
Sbjct: 206 ERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLL---SLCKEGSY 262
Query: 486 VIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHV-QHLW-FQSVLDMLRHFHTHPIP 543
++R SET P + L+ HL+ + Q + QH F SV +++ H+ + P+P
Sbjct: 263 LVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLP 322
Query: 544 LESGGSADITLRSYVRAQDP 563
++ G+ + L V Q P
Sbjct: 323 VQ--GAEHLALLYPVVTQTP 340
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G S+ + QG P L + W+HG +SR AA+ +L+ +G F++R+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-SAAEYLLSS--LINGSFLVRE 184
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V S L L H H+
Sbjct: 185 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 234
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G S+ + QG P L + W+HG +SR AA+ +L+ +G F++R+
Sbjct: 143 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-SAAEYLLSS--LINGSFLVRE 199
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V S L L H H+
Sbjct: 200 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 249
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G S+ + QG P L + W+HG +SR AA+ +L+ +G F++R+
Sbjct: 122 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-SAAEYLLSS--LINGSFLVRE 178
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V S L L H H+
Sbjct: 179 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 228
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G S+ + QG P L + W+HG +SR AA+ +L+ +G F++R+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-SAAEYLLSS--LINGSFLVRE 184
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V S L L H H+
Sbjct: 185 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 234
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 430 GSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQ 489
G S+ + QG P L + W+HG +SR AA+ +L+ +G F++R+
Sbjct: 107 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR-SAAEYLLSS--LINGSFLVRE 163
Query: 490 SETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 539
SE+ PG+ ++ ++G+ H R++ G+ +V S L L H H+
Sbjct: 164 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,696,645
Number of Sequences: 37866
Number of extensions: 1749014
Number of successful extensions: 22513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 903
Number of HSP's that attempted gapping in prelim test: 15349
Number of HSP's gapped (non-prelim): 6049
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.