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Search of human proteins with 24111228
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24111228 solute carrier family 24 member 4 isoform 1
precursor [Homo sapiens]
(605 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 1227 0.0
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 1174 0.0
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 1132 0.0
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 704 0.0
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 395 e-110
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 215 8e-56
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 203 4e-52
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 77 6e-14
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 65 1e-10
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 65 1e-10
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 63 9e-10
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 63 9e-10
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 63 9e-10
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 63 9e-10
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 60 4e-09
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 60 4e-09
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 60 8e-09
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 42 0.001
gi|8923842 forkhead box J2 [Homo sapiens] 40 0.006
gi|5730045 solute carrier family 16, member 2 [Homo sapiens] 39 0.011
gi|32307177 forkhead box G1 [Homo sapiens] 39 0.011
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 39 0.018
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 39 0.018
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 39 0.018
gi|169636435 caudal type homeobox 2 [Homo sapiens] 38 0.024
gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens] 38 0.031
gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens] 38 0.031
gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens] 38 0.031
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 1227 bits (3174), Expect = 0.0
Identities = 605/605 (100%), Positives = 605/605 (100%)
Query: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC
Sbjct: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
Query: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE
Sbjct: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
Query: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR
Sbjct: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
Query: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV
Sbjct: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
Query: 241 KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP 300
KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP
Sbjct: 241 KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP 300
Query: 301 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 360
KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG
Sbjct: 301 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 360
Query: 361 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 420
NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL
Sbjct: 361 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 420
Query: 421 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 480
CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG
Sbjct: 421 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 480
Query: 481 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 540
TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG
Sbjct: 481 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 540
Query: 541 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 600
LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM
Sbjct: 541 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 600
Query: 601 CREDD 605
CREDD
Sbjct: 601 CREDD 605
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 1174 bits (3037), Expect = 0.0
Identities = 586/605 (96%), Positives = 586/605 (96%), Gaps = 19/605 (3%)
Query: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC
Sbjct: 1 MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 60
Query: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE
Sbjct: 61 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE 120
Query: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR
Sbjct: 121 DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR 180
Query: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV
Sbjct: 181 LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV 240
Query: 241 KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP 300
KQKSIANGNPVNSELEA VKEKPQYGKNPVVMVDEIMSSSPP
Sbjct: 241 KQKSIANGNPVNSELEA-------------------VKEKPQYGKNPVVMVDEIMSSSPP 281
Query: 301 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 360
KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG
Sbjct: 282 KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG 341
Query: 361 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 420
NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL
Sbjct: 342 NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL 401
Query: 421 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 480
CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG
Sbjct: 402 CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG 461
Query: 481 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 540
TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG
Sbjct: 462 TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG 521
Query: 541 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 600
LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM
Sbjct: 522 LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM 581
Query: 601 CREDD 605
CREDD
Sbjct: 582 CREDD 586
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 1132 bits (2927), Expect = 0.0
Identities = 558/558 (100%), Positives = 558/558 (100%)
Query: 48 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 107
MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP
Sbjct: 1 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVP 60
Query: 108 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 167
SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI
Sbjct: 61 SLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 120
Query: 168 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 227
IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI
Sbjct: 121 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILI 180
Query: 228 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 287
MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP
Sbjct: 181 MKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNP 240
Query: 288 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 347
VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK
Sbjct: 241 VVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSK 300
Query: 348 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 407
PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK
Sbjct: 301 PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 360
Query: 408 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 467
VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI
Sbjct: 361 VKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGI 420
Query: 468 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 527
PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV
Sbjct: 421 PDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMV 480
Query: 528 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 587
VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM
Sbjct: 481 VNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIM 540
Query: 588 IEFNVFTFVNLPMCREDD 605
IEFNVFTFVNLPMCREDD
Sbjct: 541 IEFNVFTFVNLPMCREDD 558
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 704 bits (1818), Expect = 0.0
Identities = 359/577 (62%), Positives = 435/577 (75%), Gaps = 25/577 (4%)
Query: 44 NRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDD 103
N L + G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDD
Sbjct: 71 NDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDD 130
Query: 104 FFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 163
FFVPSLEKICERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFN
Sbjct: 131 FFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 190
Query: 164 ILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVF 223
ILCIIGVCGLFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+
Sbjct: 191 ILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLI 250
Query: 224 YILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQY 283
YI+IMKYN + F + K GN VN L + D S D +V LL K+ +
Sbjct: 251 YIVIMKYNACIHQCFERRTKGA--GNMVNG-LANNAEIDDSSNCDATVVLL---KKANFH 304
Query: 284 GKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS--- 340
K V+MVDE++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS
Sbjct: 305 RKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAY 364
Query: 341 ANGVSSKPLQNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPP 384
NG S ++ +ENG P P+ + +N+ +
Sbjct: 365 TNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEE 424
Query: 385 PEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITAT 444
E E + +PF P + + VKW FTWPL F+L T+PNC+KPRWEK+FMVTF ++T
Sbjct: 425 EEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASST 484
Query: 445 LWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSN 504
LWIA FSY+MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN
Sbjct: 485 LWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSN 544
Query: 505 TIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKW 564
+IGSNVFDIL+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW
Sbjct: 545 SIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKW 604
Query: 565 RLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMC 601
+LD+KLG L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 605 QLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMC 641
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 395 bits (1016), Expect = e-110
Identities = 223/571 (39%), Positives = 338/571 (59%), Gaps = 42/571 (7%)
Query: 50 PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 109
P++ ++N TD A ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161
Query: 110 EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 169
I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221
Query: 170 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 229
+C LF+ +++ LTWW + RD +Y + +I+LI+F D I+WWE L+L+ Y Y++ MK
Sbjct: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281
Query: 230 YNVKMQAFFTVKQKSIANGNPV--------NSELEAGNDFYDGSYDDPSVPLLGQVKEKP 281
+NV+++ + K + N N V ++ A D D+P++P K +
Sbjct: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARD-----KDEPTLP----AKPRL 328
Query: 282 QYGKNPVVMVDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII-- 330
Q G + + + +M +S + E G ++ + R R + I+
Sbjct: 329 QRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHK 388
Query: 331 -------INERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 383
++E +R +AN V L N ++E P + +P QN +
Sbjct: 389 IAKKKCHVDENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGA 446
Query: 384 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 443
+ E D + P +V ++ +P++F L +T+P+ KP KFF +TF +
Sbjct: 447 EAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGS 506
Query: 444 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 503
WIAVFSY+MVW +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS
Sbjct: 507 ITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 566
Query: 504 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 563
+++GSN+FDI VGL +PW L T++ + V ++S GL ++VLL + +L I L K
Sbjct: 567 SSVGSNIFDITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCK 625
Query: 564 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFT 594
WR+++ LG + LY +FL S+++E + T
Sbjct: 626 WRMNKILGFIMFGLYFVFLVVSVLLEDRILT 656
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 215 bits (548), Expect = 8e-56
Identities = 131/348 (37%), Positives = 191/348 (54%), Gaps = 45/348 (12%)
Query: 63 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLS 119
P +H E+P DLFS +ER+ G V+LH+ G +Y+F ALAIVCD++FVP+L I ++L +S
Sbjct: 432 PDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQIS 491
Query: 120 EDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVV 179
EDVAGATFMAAG S PELF S+IGVFI+H +VG+GTIVGSAVFNIL +IG C LF+ +++
Sbjct: 492 EDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREIL 551
Query: 180 RLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFT 239
LTWW + RD +Y + +I+LI+F D I WWE L+L++ Y FY+ MK+N ++ +
Sbjct: 552 NLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWV- 610
Query: 240 VKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSP 299
K + PV + + +D S P G + VDE+ +
Sbjct: 611 ---KEQLSRRPVAKVM---------ALEDLSKPGDG------------AIAVDELQDNK- 645
Query: 300 PKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIEN 359
K P R G + S I Q +++S + + L + E N
Sbjct: 646 -KLKLPSLLTR-------GSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLN 697
Query: 360 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDK 407
+ PQ E +P + EP + A ++P VP+ +GD+
Sbjct: 698 QGARAQ----PQAKAESKPEEE----EPAKLPAVTVTPAPVPDIKGDQ 737
Score = 184 bits (466), Expect = 3e-46
Identities = 95/244 (38%), Positives = 149/244 (61%), Gaps = 7/244 (2%)
Query: 351 NGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKW 410
+ E E E E+ Q+ +E++ + EP+ D+ PE R + +
Sbjct: 858 DSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDW------PETRQKQAIY 911
Query: 411 VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDV 470
+F P++F L +T+P+ + KFF+ TF+ + +WIA+FSY+MVW +G T+GI +
Sbjct: 912 LFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEE 971
Query: 471 IMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNY 530
IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS+++GSN+FDI VGL VPW L ++N
Sbjct: 972 IMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPW-LLFSLING 1030
Query: 531 GSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEF 590
V ++S GL ++VLL + + I KWR+++ LG + +LY +FL S+M+E
Sbjct: 1031 LQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLED 1090
Query: 591 NVFT 594
+ +
Sbjct: 1091 RIIS 1094
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/124 (27%), Positives = 61/124 (49%), Gaps = 7/124 (5%)
Query: 111 KICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGV 170
++ E + +SE++ G T +AAG+S P+L SVI GD+ V + VGS +F+I + V
Sbjct: 961 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1020
Query: 171 CGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIV--WWE-----GLVLIILYVF 223
L + L V + ++ I ++ L++ I W G + +LY
Sbjct: 1021 PWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV 1080
Query: 224 YILI 227
+++I
Sbjct: 1081 FLII 1084
Score = 38.5 bits (88), Expect = 0.018
Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 436 FMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 495
F + ++ L I Y + L +I L I + + G TF+AAG S P+ SLI
Sbjct: 460 FGMMYVFVALAIVCDEYFVPAL-GVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFI 518
Query: 496 GLGDMAVSNTIGSNVFDILVGLG 518
++ + +GS VF+IL +G
Sbjct: 519 SHSNVGIGTIVGSAVFNILFVIG 541
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 203 bits (516), Expect = 4e-52
Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Query: 390 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 449
V D S F++PEA ++ WV + P+I LL +T P+C K W+ +F++TF + +WI+
Sbjct: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347
Query: 450 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 509
F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407
Query: 510 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 569
VFD+L LG+PW ++T +N + ++NSRGL Y + L S+ L +H N W+LDRK
Sbjct: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466
Query: 570 LGVYVLVLYAIFLCFSIMIEFNV 592
LG+ L+ Y S++ E +
Sbjct: 467 LGIVCLLSYLGLATLSVLYELGI 489
Score = 185 bits (470), Expect = 9e-47
Identities = 103/282 (36%), Positives = 150/282 (53%), Gaps = 42/282 (14%)
Query: 54 TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 113
T + C EFP F+ +ER+ G ++++ L +YMF A++IVCD++F+PSLE I
Sbjct: 40 TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99
Query: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
E L LS+DVAG TFMAAGSS PEL + +GVFIT GD+G+ TI+GSA++N+L I CGL
Sbjct: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159
Query: 174 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 233
+ V L+ W + RD YTIS ++ IYD Q+ W+EG +L+++Y Y+L++ +++K
Sbjct: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219
Query: 234 MQAFFTVKQKSIA--------------------NGNPV---NSELEAGNDFYDGSYDDPS 270
+ + K G P S ++G + D Y S
Sbjct: 220 INQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLS 279
Query: 271 VPL--LGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLR 310
+ L L QV E P P F PEA L+
Sbjct: 280 ISLHGLSQVSEDP-----------------PSVFNMPEADLK 304
Score = 50.1 bits (118), Expect = 6e-06
Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 435 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 494
F ++ ++ + I Y + L II +LG+ + G TF+AAG+S P+ + + +
Sbjct: 73 FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131
Query: 495 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 554
GD+ +S +GS ++++L G+ GL + V+ S + Y++ A
Sbjct: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184
Query: 555 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 588
VLGI + + + L + + LY + LCF I I
Sbjct: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220
Score = 49.3 bits (116), Expect = 1e-05
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
E L + + V G T +AAG+S P+ ASV+ GD+ + IVGS VF++LC +G+
Sbjct: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
Query: 174 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 205
+ + A R Y TIS+ + I+F++
Sbjct: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 76.6 bits (187), Expect = 6e-14
Identities = 49/160 (30%), Positives = 86/160 (53%), Gaps = 4/160 (2%)
Query: 435 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 494
F + F+T+ LWI + +V ++ +G + + ++G+T LA G S+ D + +AR
Sbjct: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480
Query: 495 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SV 552
QG MA S G +F+ILVG+G+ G + + VK+ G LV+ + LG S+
Sbjct: 481 QGYPRMAFSACFGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL 538
Query: 553 ALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNV 592
+++ + L ++L R G +L+ Y FL +++ EF V
Sbjct: 539 VFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578
Score = 68.9 bits (167), Expect = 1e-11
Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 3/146 (2%)
Query: 82 AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 141
AV L++ LY+F L + FF P+L I L LS +VAG TF+A G+ P++F+++
Sbjct: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
Query: 142 IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 200
+ H + +G + G+ V + G G+ RD V+Y ++V +
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
Query: 201 IVFIYDEQIVWWEGLVLIILYVFYIL 226
+ ++ ++ L + LYVFY++
Sbjct: 217 FLMLFRGRVTLAWALGYLGLYVFYVV 242
Score = 37.7 bits (86), Expect = 0.031
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)
Query: 441 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 489
+ TL+++ Y+ + L ++ I TL + + G+TFLA G PD ++
Sbjct: 98 LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157
Query: 490 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 545
L+ + +T G L G GV L T VV G T+ SR +
Sbjct: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206
Query: 546 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 583
V + +V LT L + + W L LG+YV + + LC
Sbjct: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 804 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 863
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 864 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 913
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 221
++ S++ + +++ I + WEGL+ +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
Score = 36.6 bits (83), Expect = 0.069
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 831 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 890
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 891 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 920
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 877
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 221
++ S++ + +++ I + WEGL+ +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
Score = 36.6 bits (83), Expect = 0.069
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 884
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 791 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 850
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 851 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 900
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 221
++ S++ + +++ I + WEGL+ +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
Score = 36.6 bits (83), Expect = 0.069
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 818 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 877
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 878 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 907
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
FI + L I + + + L + G T+G+ D + + F+A GTSVPD AS + A Q
Sbjct: 799 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 858
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
D ++ N GSN ++ +G+GV W + + G K++ L +SV L
Sbjct: 859 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL 908
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 85 LHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 126
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 127 FMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVVRL 181
MA GSS PE+ SVI V T GD+G TIVGSA FN+ II +C G+ ++
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 182 ----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILY 221
++ S++ + +++ I + WEGL+ +
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFF 242
Score = 36.6 bits (83), Expect = 0.069
Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS V + D +G + GS N+ IGV A
Sbjct: 826 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 885
Query: 177 --QVVRLTWWAVCRDSVYYTISVIVLIVFI 204
+ V ++ +++++ + FI
Sbjct: 886 IYHAANGEQFKVSPGTLAFSVTLFTIFAFI 915
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 226
++ ++ S++ I + +++ + WEGL+ + + +L
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 227 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 279
++ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308
Query: 280 KPQYGKNPVVMVDEIMSSSPPK 301
+ + + ++ ++ P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 755 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 814
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 815 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 874
Query: 556 VL 557
VL
Sbjct: 875 VL 876
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 782 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 837
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 838 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 871
Score = 33.5 bits (75), Expect = 0.58
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 226
++ ++ S++ I + +++ + WEGL+ + + +L
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 227 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 279
++ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308
Query: 280 KPQYGKNPVVMVDEIMSSSPPK 301
+ + + ++ ++ P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871
Query: 556 VL 557
VL
Sbjct: 872 VL 873
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868
Score = 33.5 bits (75), Expect = 0.58
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 226
++ ++ S++ I + +++ + WEGL+ + + +L
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 227 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 279
++ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308
Query: 280 KPQYGKNPVVMVDEIMSSSPPK 301
+ + + ++ ++ P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875
Query: 556 VL 557
VL
Sbjct: 876 VL 877
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872
Score = 33.5 bits (75), Expect = 0.58
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 51/262 (19%)
Query: 83 VLLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 124
V+++ + +YMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 125 ATFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQV 178
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
Query: 179 VRL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL-------- 226
++ ++ S++ I + +++ + WEGL+ + + +L
Sbjct: 195 RKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Query: 227 IMKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKE 279
++ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 255 LLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KE 308
Query: 280 KPQYGKNPVVMVDEIMSSSPPK 301
+ + + ++ ++ P K
Sbjct: 309 VDESRREMIRILKDLKQKHPEK 330
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877
Query: 556 VL 557
VL
Sbjct: 878 VL 879
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874
Score = 33.5 bits (75), Expect = 0.58
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 115 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 174
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 175 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 234
Query: 556 VL 557
VL
Sbjct: 235 VL 236
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 142 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 197
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 198 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 231
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 129 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 188
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 189 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 248
Query: 556 VL 557
VL
Sbjct: 249 VL 250
Score = 35.4 bits (80), Expect = 0.15
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 156 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 211
Query: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
V + W + V ++ +++++ + F+
Sbjct: 212 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 245
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 59.7 bits (143), Expect = 8e-09
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
F + L I + + ++ L + G T+G+ D + + F+A GTS+PD AS + A Q
Sbjct: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
Query: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
D ++ N GSN ++ +GLGV W + + G ++ + L +SV L
Sbjct: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)
Query: 84 LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 125
+++ + +YMF ++I+ D F ++E I + +E V+
Sbjct: 73 VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
Query: 126 TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 180
T MA GSS PE+ SVI V G++G GTIVGSA FN+ +I VC + AG+ +
Sbjct: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191
Query: 181 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 221
+ V + ++I V LI+ ++ +V WE L+ ++ +
Sbjct: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236
Score = 35.4 bits (80), Expect = 0.15
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 118 LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 176
L + V F+A G+S P+ FAS + D +G + GS N+ +GV A
Sbjct: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838
Query: 177 QVVRLTWWAV 186
+WAV
Sbjct: 839 -----VYWAV 843
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/67 (34%), Positives = 30/67 (44%), Gaps = 9/67 (13%)
Query: 358 ENGNVPVENPEDPQQNQEQQPPPQPPP---------PEPEPVEADFLSPFSVPEARGDKV 408
++G P E+PE P PPP PPP PEP P L+P PEA +
Sbjct: 15 QDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESA 74
Query: 409 KWVFTWP 415
++T P
Sbjct: 75 TELYTEP 81
Score = 37.0 bits (84), Expect = 0.052
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 360 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFL----SPFSVPE 402
G P ++ E P ++ E PP PPPP P P A L SP +PE
Sbjct: 10 GTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPE 56
>gi|8923842 forkhead box J2 [Homo sapiens]
Length = 574
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 365 ENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARG 405
+ P PQQ Q+QQ PPQPPP + +P + +P P A G
Sbjct: 293 QQPPPPQQQQQQQQPPQPPPQQSQPQQQQ--APAQGPSAVG 331
>gi|5730045 solute carrier family 16, member 2 [Homo sapiens]
Length = 613
Score = 39.3 bits (90), Expect = 0.011
Identities = 33/110 (30%), Positives = 47/110 (42%), Gaps = 14/110 (12%)
Query: 296 SSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHE 355
SSSPP + + NK+ P++ S L + A+ + P Q E
Sbjct: 42 SSSPPSSSSCSS------RNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQE 95
Query: 356 NIENGNVPVENPEDPQQNQEQQPPPQP---PPPEPEPVEADFLSPFSVPE 402
E PV +PE P+ E +P P+P PPPEP+P P +PE
Sbjct: 96 QQE----PVGSPE-PESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPE 140
>gi|32307177 forkhead box G1 [Homo sapiens]
Length = 489
Score = 39.3 bits (90), Expect = 0.011
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 350 QNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEP 389
Q+ H + + + P P+ P Q+QQPPP PPPP P+P
Sbjct: 46 QHHHHHHHHHHHPPPPAPQPPPPPQQQQPPP-PPPPAPQP 84
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.018
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 363 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 400
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.12
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 368 EDPQQNQEQQPPPQPP----PPEPEPVEA 392
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.44
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 323 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 381
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 382 P---PPPEPEP 389
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.99
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 367 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 401
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.9
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 365 ENPEDPQQNQEQQPPPQP-PPPEPEP 389
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.018
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 363 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 400
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.12
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 368 EDPQQNQEQQPPPQPP----PPEPEPVEA 392
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.44
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 323 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 381
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 382 P---PPPEPEP 389
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.99
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 367 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 401
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.9
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 365 ENPEDPQQNQEQQPPPQP-PPPEPEP 389
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.5 bits (88), Expect = 0.018
Identities = 19/40 (47%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 363 PVENPEDPQQNQEQQPPPQP--PPPEPEPVEADFLSPFSV 400
P P PQQ +QQP PQP PPP P P + LS S+
Sbjct: 1668 PAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSM 1707
Score = 35.8 bits (81), Expect = 0.12
Identities = 16/29 (55%), Positives = 18/29 (62%), Gaps = 4/29 (13%)
Query: 368 EDPQQNQEQQPPPQPP----PPEPEPVEA 392
E P NQ+QQPPP PP PP P+P A
Sbjct: 1641 ERPPSNQQQQPPPPPPQQPQPPPPQPQPA 1669
Score = 33.9 bits (76), Expect = 0.44
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 323 LRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG-NVPVENPEDPQQNQEQQPPPQ 381
L +S ++ + + +S + + +Q + +I++ + VE P QQ Q PPPQ
Sbjct: 1598 LTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQ 1657
Query: 382 P---PPPEPEP 389
PPP+P+P
Sbjct: 1658 QPQPPPPQPQP 1668
Score = 32.7 bits (73), Expect = 0.99
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 367 PEDPQQNQ----EQQPPPQPPPPEPEPVEADFLSPFSVP 401
P PQQ Q + QP PQPPPP+ +P + P P
Sbjct: 1653 PPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPP 1691
Score = 31.2 bits (69), Expect = 2.9
Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)
Query: 365 ENPEDPQQNQEQQPPPQP-PPPEPEP 389
+ P P Q Q PPPQP P P+P P
Sbjct: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPP 1674
>gi|169636435 caudal type homeobox 2 [Homo sapiens]
Length = 313
Score = 38.1 bits (87), Expect = 0.024
Identities = 17/31 (54%), Positives = 20/31 (64%)
Query: 372 QNQEQQPPPQPPPPEPEPVEADFLSPFSVPE 402
Q Q+QQ PPQPPPP P+P + SVPE
Sbjct: 250 QQQQQQQPPQPPPPPPQPPQPQPGPLRSVPE 280
Score = 37.0 bits (84), Expect = 0.052
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 6/83 (7%)
Query: 327 SRIIINERQRLINSANGVSSKPL----QNGRHENIENGNVPVENPEDPQQNQEQQPPPQP 382
SR I R+ + + G+S + + QN R + + ++ + Q Q PPPQP
Sbjct: 208 SRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQP 267
Query: 383 PPPEPEPVEA--DFLSPFSVPEA 403
P P+P P+ + + LSP S +A
Sbjct: 268 PQPQPGPLRSVPEPLSPVSSLQA 290
>gi|195972805 myocyte enhancer factor 2A isoform 4 [Homo sapiens]
Length = 429
Score = 37.7 bits (86), Expect = 0.031
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 322 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 381
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 307 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 355
Query: 382 PPPPEPEP 389
PP P+P+P
Sbjct: 356 PPQPQPQP 363
>gi|195972803 myocyte enhancer factor 2A isoform 3 [Homo sapiens]
Length = 437
Score = 37.7 bits (86), Expect = 0.031
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 322 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 381
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 315 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 363
Query: 382 PPPPEPEP 389
PP P+P+P
Sbjct: 364 PPQPQPQP 371
>gi|195972801 myocyte enhancer factor 2A isoform 2 [Homo sapiens]
Length = 497
Score = 37.7 bits (86), Expect = 0.031
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 322 RLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQ 381
+L S + IN Q + + S+P+ R +G + QQ Q+QQ PP
Sbjct: 375 QLSQGSNLSINTNQNI-----SIKSEPISPPRDRMTPSGF------QQQQQQQQQQQPPP 423
Query: 382 PPPPEPEP 389
PP P+P+P
Sbjct: 424 PPQPQPQP 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.141 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,036,611
Number of Sequences: 37866
Number of extensions: 1209610
Number of successful extensions: 17985
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 13921
Number of HSP's gapped (non-prelim): 2702
length of query: 605
length of database: 18,247,518
effective HSP length: 108
effective length of query: 497
effective length of database: 14,157,990
effective search space: 7036521030
effective search space used: 7036521030
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.