BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|240255505 potassium channel, subfamily T, member 1 [Homo sapiens] (1235 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|240255505 potassium channel, subfamily T, member 1 [Homo sapi... 2513 0.0 gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens] 1782 0.0 gi|238624132 large conductance calcium-activated potassium chann... 130 1e-29 gi|62388890 large conductance calcium-activated potassium channe... 118 3e-26 gi|238624130 large conductance calcium-activated potassium chann... 118 4e-26 gi|26638650 large conductance calcium-activated potassium channe... 118 4e-26 gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi... 112 2e-24 gi|4504847 potassium channel, subfamily K, member 1 [Homo sapiens] 41 0.006 gi|27436996 potassium voltage-gated channel, subfamily G, member... 40 0.014 gi|24497460 Shaw-related voltage-gated potassium channel protein... 40 0.018 gi|4758624 potassium channel, subfamily K, member 6 [Homo sapiens] 40 0.018 gi|88758576 Shaw-related voltage-gated potassium channel protein... 40 0.018 gi|24497462 Shaw-related voltage-gated potassium channel protein... 40 0.018 gi|24497464 Shaw-related voltage-gated potassium channel protein... 40 0.018 gi|27436974 potassium voltage-gated channel, Shab-related subfam... 38 0.052 gi|4504849 potassium channel, subfamily K, member 3 [Homo sapiens] 38 0.068 gi|16306555 potassium channel, subfamily K, member 13 [Homo sapi... 38 0.068 gi|21217561 Shaw-related voltage-gated potassium channel protein... 38 0.068 gi|21217563 Shaw-related voltage-gated potassium channel protein... 38 0.068 gi|24497458 Shaw-related voltage-gated potassium channel protein... 38 0.068 gi|4826786 Shaw-related voltage-gated potassium channel protein ... 37 0.089 gi|163792201 Shaw-related voltage-gated potassium channel protei... 37 0.089 gi|156616271 kinesin family member 19 [Homo sapiens] 37 0.089 gi|27436984 potassium voltage-gated channel, Shal-related subfam... 37 0.12 gi|27436986 potassium voltage-gated channel, Shal-related subfam... 37 0.12 gi|27436993 potassium voltage-gated channel, subfamily G, member... 37 0.12 gi|19071574 potassium voltage-gated channel, subfamily G, member... 37 0.12 gi|27436988 potassium voltage-gated channel, subfamily G, member... 37 0.12 gi|20070166 potassium voltage-gated channel, subfamily F, member... 37 0.12 gi|11545761 potassium channel, subfamily K, member 12 [Homo sapi... 36 0.20 >gi|240255505 potassium channel, subfamily T, member 1 [Homo sapiens] Length = 1235 Score = 2513 bits (6512), Expect = 0.0 Identities = 1235/1235 (100%), Positives = 1235/1235 (100%) Query: 1 MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPRRPCAGDGALLDTAGFKMSDLDSE 60 MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPRRPCAGDGALLDTAGFKMSDLDSE Sbjct: 1 MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPRRPCAGDGALLDTAGFKMSDLDSE 60 Query: 61 VLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNF 120 VLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNF Sbjct: 61 VLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNF 120 Query: 121 SLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQ 180 SLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQ Sbjct: 121 SLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQ 180 Query: 181 VIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFL 240 VIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFL Sbjct: 181 VIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFL 240 Query: 241 NCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS 300 NCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS Sbjct: 241 NCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS 300 Query: 301 LLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSG 360 LLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSG Sbjct: 301 LLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSG 360 Query: 361 GNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVL 420 GNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVL Sbjct: 361 GNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVL 420 Query: 421 QIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKD 480 QIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKD Sbjct: 421 QIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKD 480 Query: 481 FAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ 540 FAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ Sbjct: 481 FAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ 540 Query: 541 EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKR 600 EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKR Sbjct: 541 EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKR 600 Query: 601 EDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARL 660 EDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARL Sbjct: 601 EDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARL 660 Query: 661 PVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSS 720 PVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSS Sbjct: 661 PVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSS 720 Query: 721 ALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLR 780 ALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLR Sbjct: 721 ALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLR 780 Query: 781 LDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDN 840 LDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDN Sbjct: 781 LDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDN 840 Query: 841 KPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAK 900 KPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAK Sbjct: 841 KPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAK 900 Query: 901 TIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMF 960 TIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMF Sbjct: 901 TIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMF 960 Query: 961 RLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIR 1020 RLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIR Sbjct: 961 RLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIR 1020 Query: 1021 TYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWG 1080 TYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWG Sbjct: 1021 TYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWG 1080 Query: 1081 SRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSL 1140 SRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSL Sbjct: 1081 SRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSL 1140 Query: 1141 YRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIR 1200 YRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIR Sbjct: 1141 YRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIR 1200 Query: 1201 SDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL 1235 SDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL Sbjct: 1201 SDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL 1235 >gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens] Length = 1135 Score = 1782 bits (4616), Expect = 0.0 Identities = 896/1185 (75%), Positives = 1006/1185 (84%), Gaps = 53/1185 (4%) Query: 54 MSDLDSEVLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKERLKLFFIKNQRSSL 113 M DL+SEV PLPPRYRFRDLLLGD +QNDDRVQVEFY+NENTFKERLKLFFIKNQRSSL Sbjct: 1 MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSL 60 Query: 114 RIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERK 173 RIRLFNFSLKLL+CLLYI+RVLL++P+ G W+ I WV R Sbjct: 61 RIRLFNFSLKLLSCLLYIIRVLLENPSQGN-------------------EWSHIFWVNRS 101 Query: 174 MTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRN 233 + LW +QV VA+IS ET+LL YLSYKGNIWEQI R+ F+LE+IN +PFII+IFWP LRN Sbjct: 102 LPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRN 161 Query: 234 LFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLE 293 LF+PVFLNCWLAKHALENMIND HRAI RTQSAMFNQVLIL TLLCL+FT CGIQHLE Sbjct: 162 LFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLE 221 Query: 294 RAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLW 353 R G+ L+L S YFCIVTFSTVG+GDVTP+ W S+L VV MICVALVVLP+QFE+L YLW Sbjct: 222 RIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLW 281 Query: 354 MERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMD 413 MERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMD Sbjct: 282 MERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMD 341 Query: 414 VQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTIL 473 VQVRRVLQIP+WSQRVIYLQGSALKDQDL+RAKMD+ EACFILSSR EVDRT++DHQTIL Sbjct: 342 VQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTIL 401 Query: 474 RAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLL 533 RAWAVKDFAPNCPLYVQILKPENKFH+KFADHVVCEEE KYAMLALNCICPATSTLITLL Sbjct: 402 RAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLL 461 Query: 534 VHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGV 593 VHTSRGQEGQ+SPEQWQ+MYGRCSGNEVYHI + +S FF EYEGKSFTYA+FHAHKK+GV Sbjct: 462 VHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGV 521 Query: 594 CLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGL 653 CLIG++REDNK+ILLNPGPR+I+ ++D CFYINITKEENSA FK +++++K S + Sbjct: 522 CLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSA--FKNQDQQRKSNVS-RSF 578 Query: 654 HEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPV 713 + GP+RLPVHSIIASMGTVA+DLQ T R G L+LPTE RRPSIAPV Sbjct: 579 YHGPSRLPVHSIIASMGTVAIDLQDTSCR------SASGPTLSLPTEGSKEIRRPSIAPV 632 Query: 714 LELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVK 773 LE+AD+S++ CDLLSDQSEDE TP D+E S +EY KGYPP SPYIGSSPT CHLL K Sbjct: 633 LEVADTSSIQTCDLLSDQSEDETTP-DEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEK 691 Query: 774 APFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNP 833 PFCCLRLDK C+HN YEDAKAYGFKNKLIIV+AETAGNGLYNFIVPLRAYYR +KELNP Sbjct: 692 VPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNP 751 Query: 834 IVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEE 893 IVLLLDN PD HFL+AIC FPMVYYM GS+DNLD LL+CG+ +A N+VVVDKESTMSAEE Sbjct: 752 IVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEE 811 Query: 894 DYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENG 953 DYMADAKTIVNVQT+FRLF SLSI TELTHP+NMRFMQFRAKD YSLALSKLEK+ERE G Sbjct: 812 DYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERG 871 Query: 954 SNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKIT 1013 SNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMI+ITRLLLGLDTTPGSG+LC+MKIT Sbjct: 872 SNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKIT 931 Query: 1014 EGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTR 1073 DLWIRTY RL+QKLCSS+ ++PIGIYRTES +TSE SQIS++VE+ EDT+ Sbjct: 932 ADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSE-------SQISISVEEWEDTK 984 Query: 1074 EVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWI 1133 + K R S R++ D ++HPLLRRKS+QWARRLSRK PK +G+ AE I Sbjct: 985 DSKEQGHHR------SNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGK--TAEKI 1036 Query: 1134 SQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLINPPPDTRLEPS 1193 +QQRL+LYRRSERQEL+ELVKNRMKHLGL T GYDEMNDHQ+TLSY+LINP PDTR+E + Sbjct: 1037 TQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELN 1096 Query: 1194 DIVYLIRSDPLAHVASSSQSRKSSCSHKLSSCN---PETRDETQL 1235 D+VYLIR DPLA++ +S SR++S CN ++R+ETQL Sbjct: 1097 DVVYLIRPDPLAYLPNSEPSRRNSI------CNVTGQDSREETQL 1135 >gi|238624132 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform d [Homo sapiens] Length = 1219 Score = 130 bits (326), Expect = 1e-29 Identities = 204/897 (22%), Positives = 350/897 (39%), Gaps = 127/897 (14%) Query: 177 WAIQVIVAI-ISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLF 235 + +Q+ +A + FL L +++ +W F LE+ + + F PP+ F Sbjct: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFFTV---PPV---F 259 Query: 236 IPVFLN-CWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTG---TCGIQH 291 + V+LN WL L + IL+ + + I LL + + G H Sbjct: 260 VSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIH 319 Query: 292 L-ERAGE------NLSLLTSF---YFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVV 341 L E +G+ N LT + Y +VT STVGYGDV K +L +V I L + Sbjct: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 Query: 342 LPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQD 401 E++ L R+K GG+YS KH+V+C + ++ + +FL +F H D Sbjct: 380 FASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKDRDD 435 Query: 402 YYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNE 461 V I+ + + +V + QGS L DL R K+++ +AC IL+++ Sbjct: 436 VNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYC 495 Query: 462 VDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEECK 513 D A D I+R ++K++ P + Q+L+ NK H+ K D +C E K Sbjct: 496 ADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELK 555 Query: 514 YAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFR 573 +A +C+ ST++ L + +E + WQ+ Y NE+Y + + Sbjct: 556 LGFIAQSCLAQGLSTMLANLFSMRSFIKIEE--DTWQKYYLEGVSNEMYTEYLSSA---- 609 Query: 574 EYEGKSFTYAAFHAHKKYGVCLIGLKRED---NKSILLNPGPRHILAASDTCFYINITKE 630 + G SF K + +I ++ + IL+NPG ++ I + Sbjct: 610 -FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGN-----------HLKIQEG 657 Query: 631 ENSAFIFKQEEKRKKRAFSGQGLHE---GPARLPVHSIIASMGTVAM-DLQGTEHRPTQS 686 FI ++ K+ F + H+ P R I G + D Q + P + Sbjct: 658 TLGFFIASDAKEVKRAFFYCKACHDDITDPKR------IKKCGCKRLEDEQPSTLSPKKK 711 Query: 687 GGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGL-- 744 NG P+ +P L + L+P + D + V D G+ Sbjct: 712 ------------QRNGGMRNSPNTSPKL-MRHDPLLIPGNDQIDNMDSNVKKYDSTGMFH 758 Query: 745 ----SVVEYVKGYPPNSPYIGSSPTLCHL------LPVKAPFCCLRLDKGCKHNSYEDAK 794 +E V PY+G + L +P K K E A Sbjct: 759 WCAPKEIEKVILVTGWMPYLGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKETRSEAAM 818 Query: 795 AY--GFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICC 852 G I +A GL N ++PLRA EL IV + + E + Sbjct: 819 TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN 878 Query: 853 FPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTI---VNVQTMF 909 FP V + G+ + L I D V++ + ++ + D + I +N+++M Sbjct: 879 FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQN-NIDDTSLQDKECILASLNIKSM- 936 Query: 910 RLFPSLSIT-----------TELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAF 958 + S+ + + + P N + S + ++ E N +N+ F Sbjct: 937 QFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQF 996 Query: 959 M-------------FRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP 1002 + PFA G F++S+LD+L+ ++ D ++T+ R L+ TP Sbjct: 997 LDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATP 1053 Score = 34.7 bits (78), Expect = 0.58 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 12/73 (16%) Query: 1174 QNTLSYVLINPPPDTRLEPSDIVY-LIRSD--------PLAHVASSSQ--SRKSSCSHKL 1222 Q T YV+ NPP + L P+D+++ L++ D L+H + SSQ S+KSS H + Sbjct: 1133 QCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI 1192 Query: 1223 -SSCNPETRDETQ 1234 S+ N + R +++ Sbjct: 1193 PSTANRQNRPKSR 1205 >gi|62388890 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform a [Homo sapiens] Length = 1182 Score = 118 bits (296), Expect = 3e-26 Identities = 127/493 (25%), Positives = 210/493 (42%), Gaps = 57/493 (11%) Query: 177 WAIQVIVAI-ISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLF 235 + +Q+ +A + FL L +++ +W F LE+ + + F PP+ F Sbjct: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFFTV---PPV---F 259 Query: 236 IPVFLN-CWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTG---TCGIQH 291 + V+LN WL L + IL+ + + I LL + + G H Sbjct: 260 VSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIH 319 Query: 292 L-ERAGE------NLSLLTSF---YFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVV 341 L E +G+ N LT + Y +VT STVGYGDV K +L +V I L + Sbjct: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 Query: 342 LPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQD 401 E++ L R+K GG+YS KH+V+C + ++ + +FL +F H D Sbjct: 380 FASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKDRDD 435 Query: 402 YYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNE 461 V I+ + + +V + QGS L DL R K+++ +AC IL+++ Sbjct: 436 VNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYC 495 Query: 462 VDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEECK 513 D A D I+R ++K++ P + Q+L+ NK H+ K D +C E K Sbjct: 496 ADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELK 555 Query: 514 YAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFR 573 +A +C+ ST++ L + +E + WQ+ Y NE+Y + + Sbjct: 556 LGFIAQSCLAQGLSTMLANLFSMRSFIKIEE--DTWQKYYLEGVSNEMYTEYLSSA---- 609 Query: 574 EYEGKSFTYAAFHAHKKYGVCLIGL-------KREDNKSILLNPGPRHILAASDTC--FY 624 + G SF K + +I + + K IL+NPG H+ T F Sbjct: 610 -FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPG-NHLKIQEGTLGFFI 667 Query: 625 INITKEENSAFIF 637 + KE AF + Sbjct: 668 ASDAKEVKRAFFY 680 Score = 38.5 bits (88), Expect = 0.040 Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 29/217 (13%) Query: 813 GLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQC 872 GL N ++PLRA EL IV + + E + FP V + G+ + L Sbjct: 802 GLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAV 861 Query: 873 GIIYADNLVVVDKESTMSAEEDYMADAKTIV---NVQTMFRLFPSLSITT---------- 919 I D V++ + ++ + D + I+ N+++M + S+ + Sbjct: 862 NINLCDMCVILSANQN-NIDDTSLQDKECILASLNIKSM-QFDDSIGVLQANSQGFTPPG 919 Query: 920 -ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFM-------------FRLPFA 965 + + P N + S + ++ E N +N+ F+ PFA Sbjct: 920 MDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFA 979 Query: 966 AGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP 1002 G F++S+LD+L+ ++ D ++T+ R L+ TP Sbjct: 980 CGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATP 1016 Score = 34.7 bits (78), Expect = 0.58 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 12/73 (16%) Query: 1174 QNTLSYVLINPPPDTRLEPSDIVY-LIRSD--------PLAHVASSSQ--SRKSSCSHKL 1222 Q T YV+ NPP + L P+D+++ L++ D L+H + SSQ S+KSS H + Sbjct: 1096 QCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI 1155 Query: 1223 -SSCNPETRDETQ 1234 S+ N + R +++ Sbjct: 1156 PSTANRQNRPKSR 1168 >gi|238624130 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform c [Homo sapiens] Length = 1236 Score = 118 bits (295), Expect = 4e-26 Identities = 126/489 (25%), Positives = 210/489 (42%), Gaps = 53/489 (10%) Query: 177 WAIQVIVAI-ISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLF 235 + +Q+ +A + FL L +++ +W F LE+ + + F PP+ F Sbjct: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFFTV---PPV---F 259 Query: 236 IPVFLN-CWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTG---TCGIQH 291 + V+LN WL L + IL+ + + I LL + + G H Sbjct: 260 VSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIH 319 Query: 292 L-ERAGE------NLSLLTSF---YFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVV 341 L E +G+ N LT + Y +VT STVGYGDV K +L +V I L + Sbjct: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 Query: 342 LPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQD 401 E++ L R+K GG+YS KH+V+C + ++ + +FL +F H D Sbjct: 380 FASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKDRDD 435 Query: 402 YYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNE 461 V I+ + + +V + QGS L DL R K+++ +AC IL+++ Sbjct: 436 VNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYC 495 Query: 462 VDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEECK 513 D A D I+R ++K++ P + Q+L+ NK H+ K D +C E K Sbjct: 496 ADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELK 555 Query: 514 YAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFR 573 +A +C+ ST++ L + +E + WQ+ Y NE+Y + + Sbjct: 556 LGFIAQSCLAQGLSTMLANLFSMRSFIKIEE--DTWQKYYLEGVSNEMYTEYLSSA---- 609 Query: 574 EYEGKSFTYAAFHAHKKYGVCLIGLKRED---NKSILLNPGPRHILAASDTC--FYINIT 628 + G SF K + +I ++ + IL+NPG H+ T F + Sbjct: 610 -FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPG-NHLKIQEGTLGFFIASDA 667 Query: 629 KEENSAFIF 637 KE AF + Sbjct: 668 KEVKRAFFY 676 Score = 38.5 bits (88), Expect = 0.040 Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 29/217 (13%) Query: 813 GLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQC 872 GL N ++PLRA EL IV + + E + FP V + G+ + L Sbjct: 856 GLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAV 915 Query: 873 GIIYADNLVVVDKESTMSAEEDYMADAKTIV---NVQTMFRLFPSLSITT---------- 919 I D V++ + ++ + D + I+ N+++M + S+ + Sbjct: 916 NINLCDMCVILSANQN-NIDDTSLQDKECILASLNIKSM-QFDDSIGVLQANSQGFTPPG 973 Query: 920 -ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFM-------------FRLPFA 965 + + P N + S + ++ E N +N+ F+ PFA Sbjct: 974 MDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFA 1033 Query: 966 AGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP 1002 G F++S+LD+L+ ++ D ++T+ R L+ TP Sbjct: 1034 CGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATP 1070 Score = 34.7 bits (78), Expect = 0.58 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 12/73 (16%) Query: 1174 QNTLSYVLINPPPDTRLEPSDIVY-LIRSD--------PLAHVASSSQ--SRKSSCSHKL 1222 Q T YV+ NPP + L P+D+++ L++ D L+H + SSQ S+KSS H + Sbjct: 1150 QCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI 1209 Query: 1223 -SSCNPETRDETQ 1234 S+ N + R +++ Sbjct: 1210 PSTANRQNRPKSR 1222 >gi|26638650 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b [Homo sapiens] Length = 1178 Score = 118 bits (295), Expect = 4e-26 Identities = 126/489 (25%), Positives = 210/489 (42%), Gaps = 53/489 (10%) Query: 177 WAIQVIVAI-ISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLF 235 + +Q+ +A + FL L +++ +W F LE+ + + F PP+ F Sbjct: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFFTV---PPV---F 259 Query: 236 IPVFLN-CWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTG---TCGIQH 291 + V+LN WL L + IL+ + + I LL + + G H Sbjct: 260 VSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIH 319 Query: 292 L-ERAGE------NLSLLTSF---YFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVV 341 L E +G+ N LT + Y +VT STVGYGDV K +L +V I L + Sbjct: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 Query: 342 LPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQD 401 E++ L R+K GG+YS KH+V+C + ++ + +FL +F H D Sbjct: 380 FASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKDRDD 435 Query: 402 YYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNE 461 V I+ + + +V + QGS L DL R K+++ +AC IL+++ Sbjct: 436 VNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYC 495 Query: 462 VDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEECK 513 D A D I+R ++K++ P + Q+L+ NK H+ K D +C E K Sbjct: 496 ADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELK 555 Query: 514 YAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFR 573 +A +C+ ST++ L + +E + WQ+ Y NE+Y + + Sbjct: 556 LGFIAQSCLAQGLSTMLANLFSMRSFIKIEE--DTWQKYYLEGVSNEMYTEYLSSA---- 609 Query: 574 EYEGKSFTYAAFHAHKKYGVCLIGLKRED---NKSILLNPGPRHILAASDTC--FYINIT 628 + G SF K + +I ++ + IL+NPG H+ T F + Sbjct: 610 -FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPG-NHLKIQEGTLGFFIASDA 667 Query: 629 KEENSAFIF 637 KE AF + Sbjct: 668 KEVKRAFFY 676 Score = 38.5 bits (88), Expect = 0.040 Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 29/217 (13%) Query: 813 GLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQC 872 GL N ++PLRA EL IV + + E + FP V + G+ + L Sbjct: 798 GLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAV 857 Query: 873 GIIYADNLVVVDKESTMSAEEDYMADAKTIV---NVQTMFRLFPSLSITT---------- 919 I D V++ + ++ + D + I+ N+++M + S+ + Sbjct: 858 NINLCDMCVILSANQN-NIDDTSLQDKECILASLNIKSM-QFDDSIGVLQANSQGFTPPG 915 Query: 920 -ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFM-------------FRLPFA 965 + + P N + S + ++ E N +N+ F+ PFA Sbjct: 916 MDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFA 975 Query: 966 AGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP 1002 G F++S+LD+L+ ++ D ++T+ R L+ TP Sbjct: 976 CGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATP 1012 Score = 34.7 bits (78), Expect = 0.58 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 12/73 (16%) Query: 1174 QNTLSYVLINPPPDTRLEPSDIVY-LIRSD--------PLAHVASSSQ--SRKSSCSHKL 1222 Q T YV+ NPP + L P+D+++ L++ D L+H + SSQ S+KSS H + Sbjct: 1092 QCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI 1151 Query: 1223 -SSCNPETRDETQ 1234 S+ N + R +++ Sbjct: 1152 PSTANRQNRPKSR 1164 >gi|157074214 potassium channel, subfamily U, member 1 [Homo sapiens] Length = 1149 Score = 112 bits (280), Expect = 2e-24 Identities = 113/461 (24%), Positives = 207/461 (44%), Gaps = 54/461 (11%) Query: 209 RVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNC-WLAKHALENM-------INDFHRAI 260 ++ F LEM N++ I TI PP FI +L WL L + I RAI Sbjct: 163 KIKFWLEM-NSIVDIFTI--PPT---FISYYLKSNWLGLRFLRALRLLELPQILQILRAI 216 Query: 261 LRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGE---------NLSLLTSFYFCIVT 311 + S F+++L + +L FT I +E +G+ N+S S Y + T Sbjct: 217 KTSNSVKFSKLLSI---ILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMAT 273 Query: 312 FSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTE 371 STVG+GDV K + ++ +L++ E+V L+ ++K +Y + + Sbjct: 274 TSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGK-- 331 Query: 372 KHVVLCVSSLKIDLLMDFLNEFYAHPRLQ-DYYVVILCPTEMDVQVRRVLQIPLWSQRVI 430 K +V+C ++ +D + FL F + + +V L T +++ + + L Sbjct: 332 KFIVVC-GNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKCYL--AYTT 388 Query: 431 YLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQ 490 ++ GSA+K +DL R +++ EAC I+++ D A D I+R ++K++ + +Q Sbjct: 389 FISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQ 448 Query: 491 ILKPENKFHV--------KFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEG 542 IL+ NK ++ D+++C E K +A C+ P T +T L Q Sbjct: 449 ILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVE---QNK 505 Query: 543 QESPEQ-WQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLK-- 599 + P+Q W++ + N++ R+ D ++ G SF A K + LI ++ Sbjct: 506 KVMPKQTWKKHFLNSMKNKILTQRLSD-----DFAGMSFPEVARLCFLKMHLLLIAIEYK 560 Query: 600 ---REDNKSILLNPGPRHILAASDTCFYINITKEENSAFIF 637 + ++LNP P+ + + F+I T ++ +F Sbjct: 561 SLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALF 601 Score = 57.8 bits (138), Expect = 6e-08 Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 43/231 (18%) Query: 796 YGFKNKLIIV---SAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICC 852 Y F+N ++ A +A GL NF++PLRA +RKEL IV + + Sbjct: 710 YKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWN 769 Query: 853 FPMVYYMEG--------SVDNLDSLLQCGIIY-----ADNLVVVDKESTM------SAEE 893 FP +Y + G N++ C ++ + N +VD E+ M S + Sbjct: 770 FPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQI 829 Query: 894 DYMADAKTIVNVQTMFRL--------FPSLSITTELTHPSNMRFMQFRAKDSYSLALSKL 945 D +D V+ +T + I TEL +PSN+ F++ L L Sbjct: 830 DSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIE---------QLGGL 880 Query: 946 EKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLL 996 E +E +L+ F+ G VFS S LD+LL +F +++ + ++L+ Sbjct: 881 EGSLQETNLHLS----TAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLV 927 >gi|4504847 potassium channel, subfamily K, member 1 [Homo sapiens] Length = 336 Score = 41.2 bits (95), Expect = 0.006 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 3/57 (5%) Query: 266 AMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTP 322 A+ + VL+ F T+ C F LE ++ + L SFYFC ++ ST+G GD P Sbjct: 180 AIVHAVLLGFVTVSCFFFIPAAVFSVLE---DDWNFLESFYFCFISLSTIGLGDYVP 233 >gi|27436996 potassium voltage-gated channel, subfamily G, member 4 [Homo sapiens] Length = 519 Score = 40.0 bits (92), Expect = 0.014 Identities = 20/74 (27%), Positives = 42/74 (56%), Gaps = 2/74 (2%) Query: 271 VLILFCTLLCLVFTGTCGIQHLE--RAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQ 328 +L+LF + +F+ + E R E S+ S+++ I++ +TVGYGD+ P+ P Q Sbjct: 373 LLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQ 432 Query: 329 LLVVIMICVALVVL 342 ++ + I ++++ Sbjct: 433 MVALSSILSGILIM 446 >gi|24497460 Shaw-related voltage-gated potassium channel protein 3 [Homo sapiens] Length = 757 Score = 39.7 bits (91), Expect = 0.018 Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G + ++ F Sbjct: 435 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGF 494 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ PK W L+ V+ I + + V+ F L M +QK Sbjct: 495 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 554 Query: 359 SGGNYSRH 366 ++H Sbjct: 555 LPKKKNKH 562 >gi|4758624 potassium channel, subfamily K, member 6 [Homo sapiens] Length = 313 Score = 39.7 bits (91), Expect = 0.018 Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 15/81 (18%) Query: 271 VLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQ-- 328 V++ C L+ V HLE A S L +FYFC ++ ST+G GD P P Q Sbjct: 179 VVVTVCFLVPAVI-----FAHLEEAW---SFLDAFYFCFISLSTIGLGDYVPGEAPGQPY 230 Query: 329 -----LLVVIMICVALVVLPL 344 +LV + + + LV + L Sbjct: 231 RALYKVLVTVYLFLGLVAMVL 251 >gi|88758576 Shaw-related voltage-gated potassium channel protein 4 isoform c [Homo sapiens] Length = 626 Score = 39.7 bits (91), Expect = 0.018 Identities = 34/128 (26%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS------------LLTSF 305 R + T A N+ L+L L V I + ER G S + F Sbjct: 368 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGF 427 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ PK W L+ V+ I + + V+ F L M +QK Sbjct: 428 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 487 Query: 359 SGGNYSRH 366 +H Sbjct: 488 LPKKRKKH 495 >gi|24497462 Shaw-related voltage-gated potassium channel protein 4 isoform a [Homo sapiens] Length = 635 Score = 39.7 bits (91), Expect = 0.018 Identities = 34/128 (26%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS------------LLTSF 305 R + T A N+ L+L L V I + ER G S + F Sbjct: 368 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGF 427 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ PK W L+ V+ I + + V+ F L M +QK Sbjct: 428 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 487 Query: 359 SGGNYSRH 366 +H Sbjct: 488 LPKKRKKH 495 >gi|24497464 Shaw-related voltage-gated potassium channel protein 4 isoform b [Homo sapiens] Length = 582 Score = 39.7 bits (91), Expect = 0.018 Identities = 34/128 (26%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLS------------LLTSF 305 R + T A N+ L+L L V I + ER G S + F Sbjct: 368 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGF 427 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ PK W L+ V+ I + + V+ F L M +QK Sbjct: 428 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 487 Query: 359 SGGNYSRH 366 +H Sbjct: 488 LPKKRKKH 495 >gi|27436974 potassium voltage-gated channel, Shab-related subfamily, member 2 [Homo sapiens] Length = 911 Score = 38.1 bits (87), Expect = 0.052 Identities = 48/189 (25%), Positives = 78/189 (41%), Gaps = 15/189 (7%) Query: 183 VAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNC 242 V I F LL +LS N W+ V++++ LP+ +TIF N + F N Sbjct: 239 VCIAWFTMEYLLRFLS-SPNKWKFFKGPLNVIDLLAILPYYVTIFLTE-SNKSVLQFQNV 296 Query: 243 WLAKHALENM----INDFHRAILRTQSAMFNQ--------VLILFCTLLCLVFTGTCGIQ 290 M I R QS F +LILF + ++F+ Sbjct: 297 RRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFA 356 Query: 291 HL-ERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEEL 349 E A + S+ SF++ +T +TVGYGD+ PK +++ + ++V+ L + Sbjct: 357 EKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPII 416 Query: 350 VYLWMERQK 358 V + E K Sbjct: 417 VNNFSEFYK 425 >gi|4504849 potassium channel, subfamily K, member 3 [Homo sapiens] Length = 394 Score = 37.7 bits (86), Expect = 0.068 Identities = 17/58 (29%), Positives = 30/58 (51%), Gaps = 4/58 (6%) Query: 262 RTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGD 319 R +M N VLI F + + + G H E + + ++Y+C +T +T+G+GD Sbjct: 151 RADVSMANMVLIGFFSCISTLCIGAAAFSHYE----HWTFFQAYYYCFITLTTIGFGD 204 Score = 32.3 bits (72), Expect = 2.9 Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 4/76 (5%) Query: 294 RAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLW 353 +AG SFYF I +T+GYG P ++ + + + + + F+ L Sbjct: 73 KAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSL---- 128 Query: 354 MERQKSGGNYSRHRAQ 369 ER + Y HRA+ Sbjct: 129 GERINTLVRYLLHRAK 144 >gi|16306555 potassium channel, subfamily K, member 13 [Homo sapiens] Length = 408 Score = 37.7 bits (86), Expect = 0.068 Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 3/50 (6%) Query: 271 VLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDV 320 V+++ CT L+ +C + E S S YFC V FST+G+GD+ Sbjct: 197 VMLILCTASILI---SCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDL 243 >gi|21217561 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2a [Homo sapiens] Length = 613 Score = 37.7 bits (86), Expect = 0.068 Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G ++ F Sbjct: 369 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGF 428 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ P+ W L+ V+ I + + V+ F L M +QK Sbjct: 429 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 488 Query: 359 SGGNYSRH 366 +H Sbjct: 489 LPRKRKKH 496 >gi|21217563 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2b [Homo sapiens] Length = 638 Score = 37.7 bits (86), Expect = 0.068 Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G ++ F Sbjct: 369 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGF 428 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ P+ W L+ V+ I + + V+ F L M +QK Sbjct: 429 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 488 Query: 359 SGGNYSRH 366 +H Sbjct: 489 LPRKRKKH 496 >gi|24497458 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2c [Homo sapiens] Length = 558 Score = 37.7 bits (86), Expect = 0.068 Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G ++ F Sbjct: 369 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGF 428 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ P+ W L+ V+ I + + V+ F L M +QK Sbjct: 429 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 488 Query: 359 SGGNYSRH 366 +H Sbjct: 489 LPRKRKKH 496 >gi|4826786 Shaw-related voltage-gated potassium channel protein 1 isoform B [Homo sapiens] Length = 511 Score = 37.4 bits (85), Expect = 0.089 Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G ++ F Sbjct: 332 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGF 391 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ P+ W L+ V+ I + + V+ F L M +QK Sbjct: 392 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 451 Query: 359 SGGNYSRH 366 +H Sbjct: 452 LPKKKKKH 459 >gi|163792201 Shaw-related voltage-gated potassium channel protein 1 isoform A [Homo sapiens] Length = 585 Score = 37.4 bits (85), Expect = 0.089 Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 19/128 (14%) Query: 258 RAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGEN------------LSLLTSF 305 R + T A N+ L+L L V I + ER G ++ F Sbjct: 332 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGF 391 Query: 306 YFCIVTFSTVGYGDVTPKIWPSQLL-------VVIMICVALVVLPLQFEELVYLWMERQK 358 ++ +VT +T+GYGD+ P+ W L+ V+ I + + V+ F L M +QK Sbjct: 392 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 451 Query: 359 SGGNYSRH 366 +H Sbjct: 452 LPKKKKKH 459 >gi|156616271 kinesin family member 19 [Homo sapiens] Length = 998 Score = 37.4 bits (85), Expect = 0.089 Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 20/96 (20%) Query: 639 QEEKRKKRAF--SGQGLHE------GPA--------RLPV--HSI--IASMGTVAMDLQG 678 + KR+ R+F +GQGL GP R+PV H I +G V + L Sbjct: 887 KRRKRRSRSFEVTGQGLSHPKTHLLGPHQAERISDHRMPVCRHPAPGIRHLGKVTLPLAK 946 Query: 679 TEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVL 714 + P+Q+ G G S LA+P G GSRR + P L Sbjct: 947 VKLPPSQNTGPGDSSPLAVPPNPGGGSRRATRGPRL 982 >gi|27436984 potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 1 [Homo sapiens] Length = 655 Score = 37.0 bits (84), Expect = 0.12 Identities = 25/98 (25%), Positives = 45/98 (45%), Gaps = 7/98 (7%) Query: 272 LILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLV 331 +I+F T++ G+ A + S+ SF++ IVT +T+GYGD+ PK ++ Sbjct: 332 IIIFATVMFYAEKGSS-------ASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFG 384 Query: 332 VIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQ 369 I ++V+ L +V + + RAQ Sbjct: 385 SICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 422 >gi|27436986 potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 2 [Homo sapiens] Length = 636 Score = 37.0 bits (84), Expect = 0.12 Identities = 25/98 (25%), Positives = 45/98 (45%), Gaps = 7/98 (7%) Query: 272 LILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLV 331 +I+F T++ G+ A + S+ SF++ IVT +T+GYGD+ PK ++ Sbjct: 332 IIIFATVMFYAEKGSS-------ASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFG 384 Query: 332 VIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQ 369 I ++V+ L +V + + RAQ Sbjct: 385 SICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 422 >gi|27436993 potassium voltage-gated channel, subfamily G, member 3 isoform 2 [Homo sapiens] Length = 425 Score = 37.0 bits (84), Expect = 0.12 Identities = 26/103 (25%), Positives = 53/103 (51%), Gaps = 8/103 (7%) Query: 271 VLILFCTLLCLVFTGTCGIQH---LERAGENL-SLLTSFYFCIVTFSTVGYGDVTPKIWP 326 +L+ C + + + ++H LE + ++ S+ + ++ I++ +TVGYGD+ P P Sbjct: 315 LLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVP 374 Query: 327 SQLL--VVIMICVALVVLPLQF--EELVYLWMERQKSGGNYSR 365 ++L V ++ + L+ LP+ F V + E + YSR Sbjct: 375 GRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSR 417 >gi|19071574 potassium voltage-gated channel, subfamily G, member 3 isoform 1 [Homo sapiens] Length = 436 Score = 37.0 bits (84), Expect = 0.12 Identities = 26/103 (25%), Positives = 53/103 (51%), Gaps = 8/103 (7%) Query: 271 VLILFCTLLCLVFTGTCGIQH---LERAGENL-SLLTSFYFCIVTFSTVGYGDVTPKIWP 326 +L+ C + + + ++H LE + ++ S+ + ++ I++ +TVGYGD+ P P Sbjct: 326 LLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVP 385 Query: 327 SQLL--VVIMICVALVVLPLQF--EELVYLWMERQKSGGNYSR 365 ++L V ++ + L+ LP+ F V + E + YSR Sbjct: 386 GRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSR 428 >gi|27436988 potassium voltage-gated channel, subfamily G, member 1 [Homo sapiens] Length = 513 Score = 37.0 bits (84), Expect = 0.12 Identities = 19/74 (25%), Positives = 40/74 (54%), Gaps = 2/74 (2%) Query: 271 VLILFCTLLCLVFTGTCGIQHLERAG--ENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQ 328 +L+LF + +F + E A E S+ +++ ++T +TVGYGD+ P+ P Q Sbjct: 379 LLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQ 438 Query: 329 LLVVIMICVALVVL 342 ++ + I ++++ Sbjct: 439 VVALSSILSGILLM 452 >gi|20070166 potassium voltage-gated channel, subfamily F, member 1 [Homo sapiens] Length = 494 Score = 37.0 bits (84), Expect = 0.12 Identities = 16/51 (31%), Positives = 28/51 (54%) Query: 300 SLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELV 350 S+ SF++ I+T +TVGYGD+ PK +L I ++ + L ++ Sbjct: 356 SIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPII 406 >gi|11545761 potassium channel, subfamily K, member 12 [Homo sapiens] Length = 430 Score = 36.2 bits (82), Expect = 0.20 Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 6/50 (12%) Query: 271 VLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDV 320 +L LF LL +C + + E + S YFC VTFST+G+GD+ Sbjct: 219 ILGLFAVLL------SCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDL 262 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.137 0.421 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 49,005,225 Number of Sequences: 37866 Number of extensions: 2296342 Number of successful extensions: 6734 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 48 Number of HSP's successfully gapped in prelim test: 38 Number of HSP's that attempted gapping in prelim test: 6595 Number of HSP's gapped (non-prelim): 156 length of query: 1235 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1121 effective length of database: 13,930,794 effective search space: 15616420074 effective search space used: 15616420074 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.