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Search of human proteins with 239787752
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens]
(399 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens] 837 0.0
gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens] 809 0.0
gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens] 809 0.0
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens] 764 0.0
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens] 750 0.0
gi|157820785 SH2 domain containing 7 [Homo sapiens] 107 2e-23
gi|14249584 hematopoietic SH2 domain containing [Homo sapiens] 87 2e-17
gi|21361891 SH2 domain containing 4A [Homo sapiens] 55 1e-07
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 49 6e-06
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 48 1e-05
gi|222537752 Src homology 2 domain containing transforming prote... 47 4e-05
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 45 9e-05
gi|57863248 zinc finger, CCHC domain containing 11 isoform a [Ho... 45 2e-04
gi|57863246 zinc finger, CCHC domain containing 11 isoform b [Ho... 45 2e-04
gi|57863250 zinc finger, CCHC domain containing 11 isoform c [Ho... 45 2e-04
gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 44 2e-04
gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 44 2e-04
gi|19923345 RNA binding motif protein 12 [Homo sapiens] 44 3e-04
gi|23510462 RNA binding motif protein 12 [Homo sapiens] 44 3e-04
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 42 7e-04
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 42 7e-04
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 42 7e-04
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 42 0.001
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] 41 0.002
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 40 0.003
gi|150170670 piccolo isoform 2 [Homo sapiens] 40 0.004
gi|150378539 piccolo isoform 1 [Homo sapiens] 40 0.004
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 40 0.004
gi|75677612 leucine rich repeat containing 37, member A3 [Homo s... 40 0.004
gi|50233787 nuclear protein in testis [Homo sapiens] 40 0.005
>gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens]
Length = 399
Score = 837 bits (2163), Expect = 0.0
Identities = 399/399 (100%), Positives = 399/399 (100%)
Query: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
Sbjct: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
Query: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE 120
EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE
Sbjct: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE 120
Query: 121 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 180
PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
Sbjct: 121 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 180
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 240
TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
Sbjct: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 240
Query: 241 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 300
KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
Sbjct: 241 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 300
Query: 301 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 360
AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
Sbjct: 301 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 360
Query: 361 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 399
GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
Sbjct: 361 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 399
>gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 809 bits (2089), Expect = 0.0
Identities = 389/399 (97%), Positives = 389/399 (97%), Gaps = 10/399 (2%)
Query: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
Sbjct: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
Query: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE 120
EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR EAERLLE
Sbjct: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------EAERLLE 110
Query: 121 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 180
PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
Sbjct: 111 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 170
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 240
TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
Sbjct: 171 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 230
Query: 241 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 300
KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
Sbjct: 231 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 290
Query: 301 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 360
AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
Sbjct: 291 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 350
Query: 361 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 399
GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
Sbjct: 351 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 389
>gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 809 bits (2089), Expect = 0.0
Identities = 389/399 (97%), Positives = 389/399 (97%), Gaps = 10/399 (2%)
Query: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
Sbjct: 1 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE 60
Query: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE 120
EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR EAERLLE
Sbjct: 61 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------EAERLLE 110
Query: 121 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 180
PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
Sbjct: 111 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY 170
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 240
TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
Sbjct: 171 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ 230
Query: 241 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 300
KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
Sbjct: 231 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY 290
Query: 301 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 360
AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
Sbjct: 291 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ 350
Query: 361 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 399
GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
Sbjct: 351 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ 389
>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
Length = 371
Score = 764 bits (1972), Expect = 0.0
Identities = 368/378 (97%), Positives = 368/378 (97%), Gaps = 10/378 (2%)
Query: 22 STFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKT 81
STFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKT
Sbjct: 4 STFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKT 63
Query: 82 QAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSESAVTFVLT 141
QAHWLLQHGAAPAWFHGFITRR EAERLLEPKPQGCYLVRFSESAVTFVLT
Sbjct: 64 QAHWLLQHGAAPAWFHGFITRR----------EAERLLEPKPQGCYLVRFSESAVTFVLT 113
Query: 142 YRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTP 201
YRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTP
Sbjct: 114 YRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTP 173
Query: 202 EPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPA 261
EPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPA
Sbjct: 174 EPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPA 233
Query: 262 KPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDE 321
KPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDE
Sbjct: 234 KPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDE 293
Query: 322 GLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLS 381
GLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLS
Sbjct: 294 GLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLS 353
Query: 382 RQVLQDRGQAWLPLGPPQ 399
RQVLQDRGQAWLPLGPPQ
Sbjct: 354 RQVLQDRGQAWLPLGPPQ 371
>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
Length = 361
Score = 750 bits (1937), Expect = 0.0
Identities = 361/371 (97%), Positives = 361/371 (97%), Gaps = 10/371 (2%)
Query: 29 MTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQ 88
MTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQ
Sbjct: 1 MTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQ 60
Query: 89 HGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCC 148
HGAAPAWFHGFITRR EAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCC
Sbjct: 61 HGAAPAWFHGFITRR----------EAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCC 110
Query: 149 RHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSL 208
RHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSL
Sbjct: 111 RHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSL 170
Query: 209 RTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPE 268
RTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPE
Sbjct: 171 RTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPE 230
Query: 269 VYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLG 328
VYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLG
Sbjct: 231 VYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLG 290
Query: 329 HPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDR 388
HPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDR
Sbjct: 291 HPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDR 350
Query: 389 GQAWLPLGPPQ 399
GQAWLPLGPPQ
Sbjct: 351 GQAWLPLGPPQ 361
>gi|157820785 SH2 domain containing 7 [Homo sapiens]
Length = 451
Score = 107 bits (266), Expect = 2e-23
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 10/129 (7%)
Query: 70 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLV 129
LQ WF +TQA ++LQ+GA P WFHGFITR+ + E+LL K G +L+
Sbjct: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRK----------QTEQLLRDKALGSFLI 75
Query: 130 RFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG 189
R S+ A ++L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+
Sbjct: 76 RLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFK 135
Query: 190 ETLTEPLAR 198
E LT R
Sbjct: 136 EMLTAACPR 144
>gi|14249584 hematopoietic SH2 domain containing [Homo sapiens]
Length = 352
Score = 87.4 bits (215), Expect = 2e-17
Identities = 47/125 (37%), Positives = 68/125 (54%), Gaps = 11/125 (8%)
Query: 77 WFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSESAV 136
WF TQ L Q G P WFHG I+R +AE LLE +P G +L+R S S V
Sbjct: 17 WFVHTQMGQLAQDGV-PEWFHGAISRE----------DAENLLESQPLGSFLIRVSHSHV 65
Query: 137 TFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPL 196
+ L+Y++++ C HF++ L DG ++ GE AH L L+ + P+ P E LT+P
Sbjct: 66 GYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPC 125
Query: 197 ARQTP 201
++ P
Sbjct: 126 RQKDP 130
>gi|21361891 SH2 domain containing 4A [Homo sapiens]
Length = 454
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/139 (29%), Positives = 59/139 (42%), Gaps = 17/139 (12%)
Query: 71 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVR 130
Q RA +QKT WFHG +T + + E LL G +L+R
Sbjct: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLK---------KANELLLSTGMPGSFLIR 373
Query: 131 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG- 189
SE + L+Y S C+HFL+ D + + HA L DL+ ++ P++ G
Sbjct: 374 VSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGK 433
Query: 190 ETLTEPLARQTPEPAGLSL 208
E L P +Q P L L
Sbjct: 434 ELLLYPCGQQDQLPDYLEL 452
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 49.3 bits (116), Expect = 6e-06
Identities = 58/200 (29%), Positives = 75/200 (37%), Gaps = 29/200 (14%)
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDP-NPQYSPIIKQGQAPVPM 239
T+ SP P + P P SL S S++ P + Q SPI Q P+P
Sbjct: 1035 TSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLP- 1090
Query: 240 QKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAF 299
+K+P+Q L PK P P +P PP T P P RP P PS P +A
Sbjct: 1091 ------QKDPAQPLEPKRPPPPRPVAPP---TRPAPPQRP---PPPSGRSQPSPQAGLA- 1137
Query: 300 YAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQ------NTGGSQLHS 353
G G G + + + + A H R S R P Q + G + L
Sbjct: 1138 ---GPGPAGYSTARPTIPPRAGVISAPQSH--ARASAGRLTPESQSKTSETSKGSTFLPE 1192
Query: 354 ENSVIGQGPPLPHQPPPAWR 373
PP PPPA R
Sbjct: 1193 PLKPQAAFPPQSSLPPPAQR 1212
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 48.1 bits (113), Expect = 1e-05
Identities = 39/122 (31%), Positives = 51/122 (41%), Gaps = 19/122 (15%)
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDP-NPQYSPIIKQGQAPVPM 239
T+ SP P + P P SL S S++ P + Q SPI Q P+P
Sbjct: 1040 TSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLP- 1095
Query: 240 QKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAP-----RPKPSNPIYNEPD 294
+K+P+Q L PK P P +P PP T P P RP P P P+ + P
Sbjct: 1096 ------QKDPAQPLEPKRPPPPRPVAPP---TRPAPPQRPPPPSGARSPAPTRKEFGAPK 1146
Query: 295 EP 296
P
Sbjct: 1147 SP 1148
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 46.6 bits (109), Expect = 4e-05
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 16/112 (14%)
Query: 95 WFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSES-AVTFVLTYRSRTCCRHFLL 153
WFHG + R +AE LL +G YLVR SE+ L+ RS H
Sbjct: 240 WFHGPLNRA----------DAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKF 289
Query: 154 AQLRDGRHVVLGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 201
A+ R+ + VVLG+ S + +L+LHY++ PL G L P+ QTP
Sbjct: 290 ARTRENQ-VVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 45.4 bits (106), Expect = 9e-05
Identities = 27/78 (34%), Positives = 45/78 (57%), Gaps = 3/78 (3%)
Query: 109 SVTHREAERLLEPKPQ-GCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGED 167
S++ EAE +L P+ G +L+R E + ++ +T+R+R +H + RDGRH VLG
Sbjct: 650 SLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRIN--RDGRHFVLGTS 707
Query: 168 SAHARLQDLLLHYTAHPL 185
+ L +L+ +Y H L
Sbjct: 708 AYFESLVELVSYYEKHSL 725
>gi|57863248 zinc finger, CCHC domain containing 11 isoform a [Homo
sapiens]
Length = 1645
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/223 (25%), Positives = 84/223 (37%), Gaps = 45/223 (20%)
Query: 194 EPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPV----PMQKEGAGEK-- 247
+ +A + S+RT +S+ S+S +PQ P + P + G+ K
Sbjct: 1399 QQVAGSAQQQGDQSIRTRQSSECSESPSYSPQPQPFPQNSSQSAAITQPSSQPGSQPKLG 1458
Query: 248 EPSQLLRP----KPPIPAKPQLPPEVYTIPVPRH-------RPAPRPKPSNPIYNEPDEP 296
P Q +P + P+ PQ PP Y+ P H P P PS PI+ P
Sbjct: 1459 PPQQGAQPPHQVQMPLYNFPQSPPAQYS---PMHNMGLLPMHPLQIPAPSWPIHG----P 1511
Query: 297 IAFYAMGRGSPGEAPSNI------YVEVEDEGLPATLGHPVLRKSWSRPV-PGGQNTGGS 349
+ +PG APSNI + + P + + W R V P G+
Sbjct: 1512 VI-----HSAPGSAPSNIGLNDPSIIFAQPAARPVAIPNTSHDGHWPRTVAPNSLVNSGA 1566
Query: 350 QLHSENSVIGQGPPLP--HQP-------PPAWRHTLPHNLSRQ 383
+SE G PP+P H P P +W + L N Q
Sbjct: 1567 VGNSEPGFRGLTPPIPWEHAPRPHFPLVPASWPYGLHQNFMHQ 1609
>gi|57863246 zinc finger, CCHC domain containing 11 isoform b [Homo
sapiens]
Length = 1644
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/223 (25%), Positives = 84/223 (37%), Gaps = 45/223 (20%)
Query: 194 EPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPV----PMQKEGAGEK-- 247
+ +A + S+RT +S+ S+S +PQ P + P + G+ K
Sbjct: 1398 QQVAGSAQQQGDQSIRTRQSSECSESPSYSPQPQPFPQNSSQSAAITQPSSQPGSQPKLG 1457
Query: 248 EPSQLLRP----KPPIPAKPQLPPEVYTIPVPRH-------RPAPRPKPSNPIYNEPDEP 296
P Q +P + P+ PQ PP Y+ P H P P PS PI+ P
Sbjct: 1458 PPQQGAQPPHQVQMPLYNFPQSPPAQYS---PMHNMGLLPMHPLQIPAPSWPIHG----P 1510
Query: 297 IAFYAMGRGSPGEAPSNI------YVEVEDEGLPATLGHPVLRKSWSRPV-PGGQNTGGS 349
+ +PG APSNI + + P + + W R V P G+
Sbjct: 1511 VI-----HSAPGSAPSNIGLNDPSIIFAQPAARPVAIPNTSHDGHWPRTVAPNSLVNSGA 1565
Query: 350 QLHSENSVIGQGPPLP--HQP-------PPAWRHTLPHNLSRQ 383
+SE G PP+P H P P +W + L N Q
Sbjct: 1566 VGNSEPGFRGLTPPIPWEHAPRPHFPLVPASWPYGLHQNFMHQ 1608
>gi|57863250 zinc finger, CCHC domain containing 11 isoform c [Homo
sapiens]
Length = 1640
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/223 (25%), Positives = 84/223 (37%), Gaps = 45/223 (20%)
Query: 194 EPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPV----PMQKEGAGEK-- 247
+ +A + S+RT +S+ S+S +PQ P + P + G+ K
Sbjct: 1394 QQVAGSAQQQGDQSIRTRQSSECSESPSYSPQPQPFPQNSSQSAAITQPSSQPGSQPKLG 1453
Query: 248 EPSQLLRP----KPPIPAKPQLPPEVYTIPVPRH-------RPAPRPKPSNPIYNEPDEP 296
P Q +P + P+ PQ PP Y+ P H P P PS PI+ P
Sbjct: 1454 PPQQGAQPPHQVQMPLYNFPQSPPAQYS---PMHNMGLLPMHPLQIPAPSWPIHG----P 1506
Query: 297 IAFYAMGRGSPGEAPSNI------YVEVEDEGLPATLGHPVLRKSWSRPV-PGGQNTGGS 349
+ +PG APSNI + + P + + W R V P G+
Sbjct: 1507 VI-----HSAPGSAPSNIGLNDPSIIFAQPAARPVAIPNTSHDGHWPRTVAPNSLVNSGA 1561
Query: 350 QLHSENSVIGQGPPLP--HQP-------PPAWRHTLPHNLSRQ 383
+SE G PP+P H P P +W + L N Q
Sbjct: 1562 VGNSEPGFRGLTPPIPWEHAPRPHFPLVPASWPYGLHQNFMHQ 1604
>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
Length = 1612
Score = 44.3 bits (103), Expect = 2e-04
Identities = 58/215 (26%), Positives = 79/215 (36%), Gaps = 17/215 (7%)
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDP-NPQYSPIIKQGQAPVPM 239
T+ SP P + P P SL S S++ P + Q SPI Q P+P
Sbjct: 1079 TSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLP- 1134
Query: 240 QKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAF 299
QK+ A EP + P+P P PP+ P PAP K I P +A
Sbjct: 1135 QKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPGVAR 1194
Query: 300 YAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIG 359
M EAP + +D P + + P P G +T + VI
Sbjct: 1195 REM------EAPKSPGTTRKDN---IGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVI- 1244
Query: 360 QGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLP 394
P H A R T P + S+ +G +LP
Sbjct: 1245 -SAPQSHARASAGRLT-PESQSKTSETSKGSTFLP 1277
>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
Length = 1350
Score = 44.3 bits (103), Expect = 2e-04
Identities = 58/215 (26%), Positives = 79/215 (36%), Gaps = 17/215 (7%)
Query: 181 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDP-NPQYSPIIKQGQAPVPM 239
T+ SP P + P P SL S S++ P + Q SPI Q P+P
Sbjct: 1079 TSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLP- 1134
Query: 240 QKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAF 299
QK+ A EP + P+P P PP+ P PAP K I P +A
Sbjct: 1135 QKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPGVAR 1194
Query: 300 YAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIG 359
M EAP + +D P + + P P G +T + VI
Sbjct: 1195 REM------EAPKSPGTTRKDN---IGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVI- 1244
Query: 360 QGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLP 394
P H A R T P + S+ +G +LP
Sbjct: 1245 -SAPQSHARASAGRLT-PESQSKTSETSKGSTFLP 1277
>gi|19923345 RNA binding motif protein 12 [Homo sapiens]
Length = 932
Score = 43.5 bits (101), Expect = 3e-04
Identities = 35/116 (30%), Positives = 44/116 (37%), Gaps = 21/116 (18%)
Query: 255 PKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNI 314
P PPIPA P LPP P+P P P P P+ P P P P
Sbjct: 189 PIPPIPAMPSLPPMPSIPPIPVPPPVPTLPPVPPVPPIPPVP--------SVPPMTP--- 237
Query: 315 YVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSV--IGQGPPLPHQP 368
LP G P L P+P G N G+ ++ N++ + GP P P
Sbjct: 238 --------LPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNLNPMFLGPLNPVNP 285
Score = 30.4 bits (67), Expect = 2.9
Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 21/96 (21%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR 278
S P P PI PVP P L P PP+P P +P VP
Sbjct: 198 SLPPMPSIPPI------PVP---------PPVPTLPPVPPVPPIPPVP------SVPPMT 236
Query: 279 PAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNI 314
P P P+ P P+ G G+P +N+
Sbjct: 237 PLPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNL 272
>gi|23510462 RNA binding motif protein 12 [Homo sapiens]
Length = 932
Score = 43.5 bits (101), Expect = 3e-04
Identities = 35/116 (30%), Positives = 44/116 (37%), Gaps = 21/116 (18%)
Query: 255 PKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNI 314
P PPIPA P LPP P+P P P P P+ P P P P
Sbjct: 189 PIPPIPAMPSLPPMPSIPPIPVPPPVPTLPPVPPVPPIPPVP--------SVPPMTP--- 237
Query: 315 YVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSV--IGQGPPLPHQP 368
LP G P L P+P G N G+ ++ N++ + GP P P
Sbjct: 238 --------LPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNLNPMFLGPLNPVNP 285
Score = 30.4 bits (67), Expect = 2.9
Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 21/96 (21%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR 278
S P P PI PVP P L P PP+P P +P VP
Sbjct: 198 SLPPMPSIPPI------PVP---------PPVPTLPPVPPVPPIPPVP------SVPPMT 236
Query: 279 PAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNI 314
P P P+ P P+ G G+P +N+
Sbjct: 237 PLPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNL 272
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 42.4 bits (98), Expect = 7e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 46/165 (27%)
Query: 216 GSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEP--SQLLRPKPPIPAKP-QLPPEVYTI 272
G +S P +SP G+ PVP +G EP +++ P+P + +KP +PP V +
Sbjct: 132 GGRSTSAKP-FSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPST 190
Query: 273 PVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVL 332
P P + +P + S P+ P +P SPG P
Sbjct: 191 PRP-IQSSPHNRGSPPVPGGPRQP---------SPGPTPP-------------------- 220
Query: 333 RKSWSRPVPGGQNT--GGSQLH----SENSVIGQGPPLPHQPPPA 371
P PG + T GG + S +S PPLP P A
Sbjct: 221 ------PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRA 259
Score = 32.0 bits (71), Expect = 1.0
Identities = 44/176 (25%), Positives = 58/176 (32%), Gaps = 30/176 (17%)
Query: 222 PNPQYSPIIKQGQAPVPMQKEGAGEKE---PSQLLRPKPPIPAKP------QLPPEVYTI 272
P P + K P P+ + +E P KPP+P+ P Q PP
Sbjct: 254 PTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP---- 309
Query: 273 PVPRHRPAPRPKPSNPIYNE-----PDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATL 327
P P RP P P P + N+ P ++ + P S E P +
Sbjct: 310 PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPV 369
Query: 328 GHPVLRKSWSRPVPGGQNTGGS--------QLHSENSV----IGQGPPLPHQPPPA 371
P R P P G + QL S + V G PPLP P A
Sbjct: 370 RDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 42.4 bits (98), Expect = 7e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 46/165 (27%)
Query: 216 GSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEP--SQLLRPKPPIPAKP-QLPPEVYTI 272
G +S P +SP G+ PVP +G EP +++ P+P + +KP +PP V +
Sbjct: 132 GGRSTSAKP-FSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPST 190
Query: 273 PVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVL 332
P P + +P + S P+ P +P SPG P
Sbjct: 191 PRP-IQSSPHNRGSPPVPGGPRQP---------SPGPTPP-------------------- 220
Query: 333 RKSWSRPVPGGQNT--GGSQLH----SENSVIGQGPPLPHQPPPA 371
P PG + T GG + S +S PPLP P A
Sbjct: 221 ------PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRA 259
Score = 32.0 bits (71), Expect = 1.0
Identities = 44/176 (25%), Positives = 58/176 (32%), Gaps = 30/176 (17%)
Query: 222 PNPQYSPIIKQGQAPVPMQKEGAGEKE---PSQLLRPKPPIPAKP------QLPPEVYTI 272
P P + K P P+ + +E P KPP+P+ P Q PP
Sbjct: 254 PTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP---- 309
Query: 273 PVPRHRPAPRPKPSNPIYNE-----PDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATL 327
P P RP P P P + N+ P ++ + P S E P +
Sbjct: 310 PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPV 369
Query: 328 GHPVLRKSWSRPVPGGQNTGGS--------QLHSENSV----IGQGPPLPHQPPPA 371
P R P P G + QL S + V G PPLP P A
Sbjct: 370 RDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 42.4 bits (98), Expect = 7e-04
Identities = 43/156 (27%), Positives = 59/156 (37%), Gaps = 21/156 (13%)
Query: 190 ETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEP 249
E+ TE TPEPA TE ++ + P P + P P E A E P
Sbjct: 72 ESATELYTEPTPEPA-----TEPASEPAPEPATEPAPEPATEPAPEPAP---EPATESAP 123
Query: 250 SQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNE--PDEPIAFYAMGRGSP 307
P+P + + P+ PE+ P P P P+P + E P+ F R SP
Sbjct: 124 EPT--PEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEFCPEAAPEF----RPSP 177
Query: 308 GEAPSNIYVEVEDEGL-----PATLGHPVLRKSWSR 338
V+ + GL P+ P SWSR
Sbjct: 178 APCLLQCPVDTRERGLKTSPSPSPSPSPRTPMSWSR 213
Score = 35.0 bits (79), Expect = 0.12
Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 11/73 (15%)
Query: 232 QGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPP---EVYTIPVPRHRP--APRPKP- 285
QG AP ++ A EP P PP PA P PP E P+P P AP P P
Sbjct: 9 QGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPE 68
Query: 286 -----SNPIYNEP 293
+ +Y EP
Sbjct: 69 ATSESATELYTEP 81
Score = 30.0 bits (66), Expect = 3.8
Identities = 36/130 (27%), Positives = 48/130 (36%), Gaps = 16/130 (12%)
Query: 217 SKSQDPNPQYSPIIKQGQAPV--PMQKEGAGEK--EPSQLLRPKPPIPAKPQLPPEVYTI 272
++S +P P + P P P+ E + E EP L P P A + E+YT
Sbjct: 21 AESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTE 80
Query: 273 PVPRHRPAPRPKPSNPIYNEP-DEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPV 331
P P P +P+ EP EP +P AP E E P P
Sbjct: 81 PTPEPATEPASEPAPEPATEPAPEPAT-----EPAPEPAP-----EPATESAPEPTPEPA 130
Query: 332 LRKSWSRPVP 341
L +S P P
Sbjct: 131 L-ESVPEPAP 139
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 41.6 bits (96), Expect = 0.001
Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 5/113 (4%)
Query: 195 PLARQTPEPAGLSLRTEESNFGSKSQDPNPQYS-PIIKQGQAPVPMQKEGAGEKEPSQLL 253
P +Q P L+L S + + P PQ S P + + P+P + + + +
Sbjct: 751 PTLKQHSHPPPLALG---SGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRW 807
Query: 254 RPKPPIPAKPQLP-PEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRG 305
R P+P P LP P + I P RP P PI + P EP RG
Sbjct: 808 RYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRG 860
>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
Length = 1003
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/236 (25%), Positives = 82/236 (34%), Gaps = 38/236 (16%)
Query: 185 LSPY-GETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYS-----PIIKQGQAPVP 238
LSP G +L L+ T P L S Q P P S ++ G AP P
Sbjct: 736 LSPLLGASLLGDLSSLTSSPGALP---------SLLQPPGPLLSGQLGLQLLPGGGAPPP 786
Query: 239 MQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSN---PIYNEPDE 295
+ + + Q L+ P P P LPPE P P P P + P + PD
Sbjct: 787 LSEASSPLACLLQSLQIPPEQPEAPCLPPE---SPASALEPEPARPPLSALAPPHGSPDP 843
Query: 296 PIAFYAMGRGS--PGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHS 353
P+ GRGS G + E PA P R+ R GG
Sbjct: 844 PVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQM 903
Query: 354 E-----------NSVIGQGPPLPHQPPPAWRHT----LPHNLSRQVLQDRGQAWLP 394
E N + +G P PPP H+ +P + R+ + R + + P
Sbjct: 904 ERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNP 959
Score = 33.1 bits (74), Expect = 0.45
Identities = 38/140 (27%), Positives = 50/140 (35%), Gaps = 34/140 (24%)
Query: 255 PKPPIPAKPQLPP----EVYTIPVPRHRPAPRPKP--SNPIYNEPDE----------PIA 298
P+P P +P LP + ++P PA P +P+ P E P+
Sbjct: 451 PQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLP 510
Query: 299 FYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPG--------GQNTGGSQ 350
A G P +P + + G P LG L S +P P G TGG
Sbjct: 511 PLAGGEAFPFPSPEQ-GLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGG- 568
Query: 351 LHSENSVIGQGPPLPHQPPP 370
GQ PP P PPP
Sbjct: 569 --------GQPPPEPLLPPP 580
Score = 29.6 bits (65), Expect = 5.0
Identities = 39/141 (27%), Positives = 52/141 (36%), Gaps = 31/141 (21%)
Query: 217 SKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTI---- 272
+K+Q P P P QG+ P + A S LRP +P+ PP V+ +
Sbjct: 328 AKAQHP-PLPPPSTLQGRRP----RAQAPSASHSSSLRPSQ---RRPRRPPTVFRLLEGR 379
Query: 273 ------------PVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVED 320
P P +P P+PS PI P +G +PG PS+
Sbjct: 380 GPQTPRRSRPRAPAPVPQPFSLPEPSQPIL-----PSVLSLLGLPTPG--PSHSDGSFNL 432
Query: 321 EGLPATLGHPVLRKSWSRPVP 341
G A L P S S P P
Sbjct: 433 LGSDAHLPPPPTLSSGSPPQP 453
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 40.4 bits (93), Expect = 0.003
Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 12/95 (12%)
Query: 95 WFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSESAVT-FVLTYRSRTCCRHFLL 153
W+HG I+R EAE L+P + YLVR SES + + + ++ C H ++
Sbjct: 395 WYHGAISRA----------EAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIV 444
Query: 154 AQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPY 188
AQ +D ++ L + SA ++HY ++ P+
Sbjct: 445 AQTKDNKY-TLNQTSAVFDSIPEVVHYYSNEKLPF 478
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 14/98 (14%)
Query: 200 TPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPI 259
TP+P ++ S ++ P P +P+ + G +P Q+ G G+ Q KPP
Sbjct: 417 TPKPLA-----QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS 471
Query: 260 ----PAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEP 293
PAKP PP+ P P P +P + P +P
Sbjct: 472 QLPGPAKP--PPQQ---PGPAKPPPQQPGSAKPPSQQP 504
Score = 39.7 bits (91), Expect = 0.005
Identities = 38/122 (31%), Positives = 55/122 (45%), Gaps = 17/122 (13%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQ---LLRPKP--PIPAKPQLPPEVYTIP 273
SQ P P P + G A P Q+ G+ K PSQ +P P P PAKP P + +
Sbjct: 471 SQLPGPAKPPPQQPGPAKPPPQQPGSA-KPPSQQPGSTKPPPQQPGPAKPS-PQQPGSTK 528
Query: 274 VPRHRP------APRPKPSNPIYNEPDEPIAFYAMGRGSPGEAP--SNIYVEVEDEGLPA 325
P +P A +P P+ P + +P++ G G P + P S + +GLP
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS--QTGSGKPLQPPTVSPSAKQPPSQGLPK 586
Query: 326 TL 327
T+
Sbjct: 587 TI 588
Score = 33.9 bits (76), Expect = 0.27
Identities = 29/135 (21%), Positives = 52/135 (38%), Gaps = 9/135 (6%)
Query: 191 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSP-IIKQGQAPVPMQKEGAGEKEP 249
T T +++ +P+P S + + + S+ P P+ P ++KQ + E
Sbjct: 667 TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 250 SQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGE 309
L +P PP +P +P E PV KP P +P + + P
Sbjct: 727 DSLSKPAPP--KEPSVPSEQDKAPV------ADDKPKQPKMVKPTTDLVSSSSATTKPDI 778
Query: 310 APSNIYVEVEDEGLP 324
S + + E++ P
Sbjct: 779 PSSKVQSQAEEKTTP 793
Score = 33.1 bits (74), Expect = 0.45
Identities = 50/211 (23%), Positives = 81/211 (38%), Gaps = 27/211 (12%)
Query: 190 ETLTEPLARQTPEPAGLSLRTEE--SNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEK 247
E T PL + +P+ T E S F SK+ S II P P E G+K
Sbjct: 789 EKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH---PGP-SSESKGQK 844
Query: 248 EPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR---PAPRPK-----PSNPIYNEPDEPIAF 299
+ + + + P A+ ++ P+ P+P+ P PRP P+ +P E
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904
Query: 300 YAMGRGSPGEAPSNIYVEVEDEGLPATLGHPV--------LRKSWSRPVPGGQNTGGSQL 351
+++ GS +AP + ++ G L + +P P Q+ G+ +
Sbjct: 905 FSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPM 964
Query: 352 HS----ENSVIGQGPP-LPHQPPPAWRHTLP 377
QGPP Q PPA ++P
Sbjct: 965 KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIP 995
Score = 30.0 bits (66), Expect = 3.8
Identities = 37/159 (23%), Positives = 56/159 (35%), Gaps = 33/159 (20%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR 278
+Q P ++ + Q A P K+ + S ++P P P+KP
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGES--VKPSLPSPSKP--------------- 304
Query: 279 PAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSR 338
P +P P P +P + G P PS + + + P T+ PV ++
Sbjct: 305 PIQQPTPGKPPAQQPGHEKS--QPGPAKPPAQPSGLTKPLAQQ--PGTVKPPVQPPGTTK 360
Query: 339 P--------VPGGQNTGGSQLHSENSVIGQGPPLPHQPP 369
P P Q TG + SE GP QPP
Sbjct: 361 PPAQPLGPAKPPAQQTGSEKPSSEQ----PGPKALAQPP 395
Score = 29.3 bits (64), Expect = 6.6
Identities = 24/112 (21%), Positives = 39/112 (34%), Gaps = 11/112 (9%)
Query: 189 GETLTEPLARQTPEPAGLSLRTEESNFGSKSQD-----------PNPQYSPIIKQGQAPV 237
G+ + P + A L L+ + S +K D P+P PI +
Sbjct: 255 GKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP 314
Query: 238 PMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPI 289
P Q+ G + +P P P L + T+ P P P+ P+
Sbjct: 315 PAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL 366
Score = 28.9 bits (63), Expect = 8.6
Identities = 14/35 (40%), Positives = 17/35 (48%), Gaps = 5/35 (14%)
Query: 254 RPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNP 288
+P PP P P PP P P P P P P++P
Sbjct: 2404 QPPPPPPPPPPPPP-----PPPPPPPPPLPPPTSP 2433
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 14/98 (14%)
Query: 200 TPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPI 259
TP+P ++ S ++ P P +P+ + G +P Q+ G G+ Q KPP
Sbjct: 417 TPKPLA-----QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS 471
Query: 260 ----PAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEP 293
PAKP PP+ P P P +P + P +P
Sbjct: 472 QLPGPAKP--PPQQ---PGPAKPPPQQPGSAKPPSQQP 504
Score = 39.7 bits (91), Expect = 0.005
Identities = 38/122 (31%), Positives = 55/122 (45%), Gaps = 17/122 (13%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQ---LLRPKP--PIPAKPQLPPEVYTIP 273
SQ P P P + G A P Q+ G+ K PSQ +P P P PAKP P + +
Sbjct: 471 SQLPGPAKPPPQQPGPAKPPPQQPGSA-KPPSQQPGSTKPPPQQPGPAKPS-PQQPGSTK 528
Query: 274 VPRHRP------APRPKPSNPIYNEPDEPIAFYAMGRGSPGEAP--SNIYVEVEDEGLPA 325
P +P A +P P+ P + +P++ G G P + P S + +GLP
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS--QTGSGKPLQPPTVSPSAKQPPSQGLPK 586
Query: 326 TL 327
T+
Sbjct: 587 TI 588
Score = 33.9 bits (76), Expect = 0.27
Identities = 29/135 (21%), Positives = 52/135 (38%), Gaps = 9/135 (6%)
Query: 191 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSP-IIKQGQAPVPMQKEGAGEKEP 249
T T +++ +P+P S + + + S+ P P+ P ++KQ + E
Sbjct: 667 TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 250 SQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGE 309
L +P PP +P +P E PV KP P +P + + P
Sbjct: 727 DSLSKPAPP--KEPSVPSEQDKAPV------ADDKPKQPKMVKPTTDLVSSSSATTKPDI 778
Query: 310 APSNIYVEVEDEGLP 324
S + + E++ P
Sbjct: 779 PSSKVQSQAEEKTTP 793
Score = 33.1 bits (74), Expect = 0.45
Identities = 50/211 (23%), Positives = 81/211 (38%), Gaps = 27/211 (12%)
Query: 190 ETLTEPLARQTPEPAGLSLRTEE--SNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEK 247
E T PL + +P+ T E S F SK+ S II P P E G+K
Sbjct: 789 EKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH---PGP-SSESKGQK 844
Query: 248 EPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR---PAPRPK-----PSNPIYNEPDEPIAF 299
+ + + + P A+ ++ P+ P+P+ P PRP P+ +P E
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904
Query: 300 YAMGRGSPGEAPSNIYVEVEDEGLPATLGHPV--------LRKSWSRPVPGGQNTGGSQL 351
+++ GS +AP + ++ G L + +P P Q+ G+ +
Sbjct: 905 FSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPM 964
Query: 352 HS----ENSVIGQGPP-LPHQPPPAWRHTLP 377
QGPP Q PPA ++P
Sbjct: 965 KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIP 995
Score = 30.0 bits (66), Expect = 3.8
Identities = 37/159 (23%), Positives = 56/159 (35%), Gaps = 33/159 (20%)
Query: 219 SQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHR 278
+Q P ++ + Q A P K+ + S ++P P P+KP
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGES--VKPSLPSPSKP--------------- 304
Query: 279 PAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSR 338
P +P P P +P + G P PS + + + P T+ PV ++
Sbjct: 305 PIQQPTPGKPPAQQPGHEKS--QPGPAKPPAQPSGLTKPLAQQ--PGTVKPPVQPPGTTK 360
Query: 339 P--------VPGGQNTGGSQLHSENSVIGQGPPLPHQPP 369
P P Q TG + SE GP QPP
Sbjct: 361 PPAQPLGPAKPPAQQTGSEKPSSEQ----PGPKALAQPP 395
Score = 29.3 bits (64), Expect = 6.6
Identities = 24/112 (21%), Positives = 39/112 (34%), Gaps = 11/112 (9%)
Query: 189 GETLTEPLARQTPEPAGLSLRTEESNFGSKSQD-----------PNPQYSPIIKQGQAPV 237
G+ + P + A L L+ + S +K D P+P PI +
Sbjct: 255 GKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP 314
Query: 238 PMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPI 289
P Q+ G + +P P P L + T+ P P P+ P+
Sbjct: 315 PAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL 366
Score = 28.9 bits (63), Expect = 8.6
Identities = 14/35 (40%), Positives = 17/35 (48%), Gaps = 5/35 (14%)
Query: 254 RPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNP 288
+P PP P P PP P P P P P P++P
Sbjct: 2404 QPPPPPPPPPPPPP-----PPPPPPPPPLPPPTSP 2433
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 40.0 bits (92), Expect = 0.004
Identities = 33/136 (24%), Positives = 55/136 (40%), Gaps = 13/136 (9%)
Query: 181 TAHPLS--PYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQ----GQ 234
T P S P G P + P P + E + +DP + + + G+
Sbjct: 342 TPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGR 401
Query: 235 AP-VPMQKEGAGEKEPSQLLRPKPPI-PAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNE 292
AP V +++ E+ P++ P + PA P + P + P P PAP P P+ + +
Sbjct: 402 APLVKVEEATVEERTPAE-----PEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA 456
Query: 293 PDEPIAFYAMGRGSPG 308
P + A + S G
Sbjct: 457 PSSTVNASASVKTSAG 472
>gi|75677612 leucine rich repeat containing 37, member A3 [Homo
sapiens]
Length = 1634
Score = 40.0 bits (92), Expect = 0.004
Identities = 47/218 (21%), Positives = 86/218 (39%), Gaps = 22/218 (10%)
Query: 186 SPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQG--QAPVPMQKEG 243
+PY +L L ++ EP G S + S F + + NP+ I+ Q P Q
Sbjct: 189 TPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQ 248
Query: 244 AGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMG 303
E+EPS + + P +P + + ++ +P H + +P P E A+Y +
Sbjct: 249 LLEEEPSSMQQEAPALPPESSME----SLTLPNHEVSVQP---------PGEDQAYYHLP 295
Query: 304 RGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPP 363
+ P+++ V + E T +++ P+ + S E + PP
Sbjct: 296 NIT--VKPADVEVTITSEPTNETESSQAQQET---PIQFPEEVEPSATQQEAPIEPPVPP 350
Query: 364 LPHQPPPAWRH--TLPHNLSRQVLQDRGQAWLPLGPPQ 399
+ H+ + + P SR+V Q P PP+
Sbjct: 351 MEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPE 388
>gi|50233787 nuclear protein in testis [Homo sapiens]
Length = 1132
Score = 39.7 bits (91), Expect = 0.005
Identities = 46/163 (28%), Positives = 63/163 (38%), Gaps = 37/163 (22%)
Query: 249 PSQLLRPKP---PIPAKPQLPPEVYTIPVPRHRP-APRPKPSNPIYNEPDEPIAFYAM-- 302
P ++P P PA P LPP T P H P P P+P P PD P+ A
Sbjct: 12 PDMSMKPSAALSPSPALPFLPP---TSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPS 68
Query: 303 -----GRGSP---GEAPSNIYVEVEDEG---LPATLGHPVLRKSWSRPVPGGQNTGGSQ- 350
G G P G + V+V+ EG P+ + +L ++ G GG +
Sbjct: 69 SLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEG 128
Query: 351 -----LHSEN----------SVIGQGPP-LPHQPPPAWRHTLP 377
+ + N V +GPP LP QPPP +P
Sbjct: 129 PAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVP 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,572,256
Number of Sequences: 37866
Number of extensions: 1424734
Number of successful extensions: 9826
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 669
Number of HSP's that attempted gapping in prelim test: 6865
Number of HSP's gapped (non-prelim): 2522
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.