Guide to the Human Genome
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Search of human proteins with 239758013

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
         (819 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]          1626   0.0  
gi|239758117 PREDICTED: hypothetical protein [Homo sapiens]           147   5e-35
gi|239758008 PREDICTED: hypothetical protein XP_002346266 [Homo ...   135   2e-31
gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo ...   127   4e-29
gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo ...   122   1e-27
gi|239741651 PREDICTED: hypothetical protein XP_002342270 [Homo ...   115   2e-25
gi|57864582 hornerin [Homo sapiens]                                   103   6e-22
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        98   4e-20
gi|60097902 filaggrin [Homo sapiens]                                   96   1e-19
gi|158854042 hypothetical protein LOC222183 [Homo sapiens]             92   3e-18
gi|239756562 PREDICTED: hypothetical protein [Homo sapiens]            89   1e-17
gi|239754474 PREDICTED: similar to mucin [Homo sapiens]                88   3e-17
gi|239752579 PREDICTED: hypothetical protein XP_002348295 [Homo ...    88   4e-17
gi|239752632 PREDICTED: hypothetical protein XP_002347697 [Homo ...    86   2e-16
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         84   4e-16
gi|239754599 PREDICTED: hypothetical protein [Homo sapiens]            82   2e-15
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     80   6e-15
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    77   6e-14
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    77   6e-14
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    77   6e-14
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    77   6e-14
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]     76   1e-13
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]     76   1e-13
gi|62122917 filaggrin family member 2 [Homo sapiens]                   74   4e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    73   9e-13
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       72   3e-12
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      71   5e-12
gi|239757861 PREDICTED: similar to armadillo repeat containing, ...    70   1e-11
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    70   1e-11
gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]            69   1e-11

>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 819

 Score = 1626 bits (4210), Expect = 0.0
 Identities = 819/819 (100%), Positives = 819/819 (100%)

Query: 1   MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR 60
           MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR
Sbjct: 1   MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR 60

Query: 61  RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
           RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG
Sbjct: 61  RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120

Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
           RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA
Sbjct: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180

Query: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
           GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG
Sbjct: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240

Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
           GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA
Sbjct: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300

Query: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360
           KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK
Sbjct: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360

Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
           QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR
Sbjct: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420

Query: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS 480
           GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS
Sbjct: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS 480

Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV
Sbjct: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540

Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
           GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA
Sbjct: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600

Query: 601 AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ 660
           AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ
Sbjct: 601 AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ 660

Query: 661 PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL 720
           PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL
Sbjct: 661 PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL 720

Query: 721 GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780
           GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA
Sbjct: 721 GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780

Query: 781 VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
           VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR
Sbjct: 781 VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819


>gi|239758117 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 465

 Score =  147 bits (370), Expect = 5e-35
 Identities = 126/326 (38%), Positives = 159/326 (48%), Gaps = 72/326 (22%)

Query: 153 RGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS------GKKPRRRGAKSRGDEDK--- 203
           R +    A A   +  +G  + +   AA A+ +S      GK+P  + + +R D  +   
Sbjct: 68  RDSRVTPATALLLLSHRGRAQRRSIQAAAAQEQSTGRGCLGKEPPSQESWTRSDPRRCLS 127

Query: 204 ----KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAAT-G 258
               +   R  +SR  +TRGG  K+ RR K A  GAKSR G GKKPQ   RRGQKAAT G
Sbjct: 128 QDAVRSGSRVCRSR-PQTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQ---RRGQKAATAG 183

Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW 318
            KSR G  R  G KK+RR GQ  A AGAKR G                            
Sbjct: 184 AKSRGGGVRSLGGKKMRR-GQKGA-AGAKRCG---------------------------- 213

Query: 319 GRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGA 378
             GGK+PRRRGQKA+K+     +      QKAA  GVKSRKK R+RG+K       AA  
Sbjct: 214 --GGKQPRRRGQKASKSGGVRCQT----PQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAG 267

Query: 379 KSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR-------RG 431
           K+ GGG +      K RG G KKP  +N R R QKA AA     G KKP++       R 
Sbjct: 268 KTCGGGGE------KHRGGGDKKPLRKNSRWRGQKAAAA-----GGKKPQKAAAAGGERR 316

Query: 432 PKAAKSRGGKSRSGGGKKPRRRGQKA 457
            K  + +   +R+   KKPR RGQ +
Sbjct: 317 KKLRRQKAAVARAKSPKKPRWRGQNS 342



 Score =  127 bits (319), Expect = 4e-29
 Identities = 135/364 (37%), Positives = 160/364 (43%), Gaps = 108/364 (29%)

Query: 286 AKRRGAATAGEKPAAKGRG--GRGPKSLGGQNPRWGRGGKKPRR-RGQKATKAAAAGTK- 341
           A+RR    A  +  + GRG  G+ P S       W R    PRR   Q A ++ +   + 
Sbjct: 87  AQRRSIQAAAAQEQSTGRGCLGKEPPS----QESWTRSD--PRRCLSQDAVRSGSRVCRS 140

Query: 342 ----RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD 397
               RGGGG+Q                   PRRQKA+ AGAKSRGG  KK          
Sbjct: 141 RPQTRGGGGKQ-------------------PRRQKAAVAGAKSRGGEGKK---------- 171

Query: 398 GRKKPRWQNPRRRAQKA--PAAKPRGGGSK----KPRRRGPKAAKSRGGKSRSGGGKKPR 451
                    P+RR QKA    AK RGGG +    K  RRG K A    G  R GGGK+PR
Sbjct: 172 ---------PQRRGQKAATAGAKSRGGGVRSLGGKKMRRGQKGA---AGAKRCGGGKQPR 219

Query: 452 RRGQKAR----------QKAAEAGAESRGDKKQGRQKASAA-------------GTKSRG 488
           RRGQKA           QKAA  G +SR   +Q  QKA+AA             G K RG
Sbjct: 220 RRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAGKTCGGGGEKHRG 279

Query: 489 GGLKSHSGKNLWRRGQKAEAAG----EKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSK 544
           GG K    KN   RGQKA AAG    +KA AAG +   RK+ RRQK AVA AKS     K
Sbjct: 280 GGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAGGER--RKKLRRQKAAVARAKS---PKK 334

Query: 545 SRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG-------GDKQPGW 597
            R R +        + G G +  R     +    G+     K  GG        D+ P W
Sbjct: 335 PRWRGQ--------NSGNGVEGQRSLAFLEFDVEGKVQRKTKIPGGVVKQFVPADQGPLW 386

Query: 598 QKAA 601
           QKAA
Sbjct: 387 QKAA 390



 Score =  122 bits (306), Expect = 1e-27
 Identities = 117/293 (39%), Positives = 138/293 (47%), Gaps = 52/293 (17%)

Query: 469 RGDKKQGRQKASAAGTKSRGGGL--KSHSGKNLWRRGQKAEAAGEKATAAGAK------- 519
           RG  ++   +A+AA  +S G G   K    +  W R        + A  +G++       
Sbjct: 84  RGRAQRRSIQAAAAQEQSTGRGCLGKEPPSQESWTRSDPRRCLSQDAVRSGSRVCRSRPQ 143

Query: 520 --SRGRKQPRRQKPAVAGAKSRVGGSKSRQR--QKAVAAGATSHGGGGNKQSRGGGGNKP 575
               G KQPRRQK AVAGAKSR G  K  QR  QKA  AGA S GGG     R  GG K 
Sbjct: 144 TRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGG----VRSLGGKKM 199

Query: 576 RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
           R+ GQ  AA   R GG KQP       G   S+SG G +    QKAA  G KSRKK  +R
Sbjct: 200 RR-GQKGAAGAKRCGGGKQP----RRRGQKASKSG-GVRCQTPQKAAAQGVKSRKKLRQR 253

Query: 636 GQKDAAAAEKAWA------TGATSRGSGGKQP-----RW--QKPAAAGSES-SAAAAVGQ 681
           GQK AAA ++A A       G   RG G K+P     RW  QK AAAG +    AAA G 
Sbjct: 254 GQKAAAAGQEAAAGKTCGGGGEKHRGGGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAG- 312

Query: 682 EAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGS 734
             E RKK RR          Q AAV      +  KKPR      G G + + S
Sbjct: 313 -GERRKKLRR----------QKAAVA---RAKSPKKPRWRGQNSGNGVEGQRS 351



 Score =  108 bits (269), Expect = 3e-23
 Identities = 105/271 (38%), Positives = 135/271 (49%), Gaps = 76/271 (28%)

Query: 53  GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG 112
           G G K+ RRQKAA  G K+R         GK+ ++  QKAA AG A++RGGG        
Sbjct: 146 GGGGKQPRRQKAAVAGAKSR------GGEGKKPQRRGQKAATAG-AKSRGGG-------- 190

Query: 113 TKSLGGRGRKPRRRGQKAAAT-----GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVK 167
            +SLGG   K  RRGQK AA      G K+PR R QK++ +G               GV+
Sbjct: 191 VRSLGG---KKMRRGQKGAAGAKRCGGGKQPRRRGQKASKSG---------------GVR 232

Query: 168 SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
            Q    PQKAAA G KSR  KK R+RG K+       G++  A    GKT GG       
Sbjct: 233 CQ---TPQKAAAQGVKSR--KKLRQRGQKAAA----AGQEAAA----GKTCGG------- 272

Query: 228 PKPAAGGAKSRRGGGKKP--QKQRRRGQK-AATGGKSRVGKSRGGGDKKLRRQGQNAALA 284
                GG K R GG KKP  +  R RGQK AA GGK     +  GG+++ + + Q AA+A
Sbjct: 273 -----GGEKHRGGGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAGGERRKKLRRQKAAVA 327

Query: 285 GAKRRGAATAGEKPAAKGR----GGRGPKSL 311
            AK      + +KP  +G+    G  G +SL
Sbjct: 328 RAK------SPKKPRWRGQNSGNGVEGQRSL 352



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 82/245 (33%), Positives = 109/245 (44%), Gaps = 55/245 (22%)

Query: 616 AWRQKAAGTGAKSRKKP----WRRGQKDAAAAEKAWATGAT-------SRGSGGKQPRWQ 664
           A ++++ G G   ++ P    W R       ++ A  +G+        +RG GGKQPR Q
Sbjct: 96  AAQEQSTGRGCLGKEPPSQESWTRSDPRRCLSQDAVRSGSRVCRSRPQTRGGGGKQPRRQ 155

Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW----QRRGKKPRL 720
           K A AG++S             KKP+RR  K+   G ++   G+        RRG+K   
Sbjct: 156 KAAVAGAKSRGGEG--------KKPQRRGQKAATAGAKSRGGGVRSLGGKKMRRGQKGAA 207

Query: 721 GKSRGGGGAKSRGSGGAKSRGSG------------GAKSR------------SGKKAAAS 756
           G  R GGG + R  G   S+  G            G KSR            +G++AAA 
Sbjct: 208 GAKRCGGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAG 267

Query: 757 KSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG------RGQKAA 810
           K+ GGGG K R GG  K     K     GQKAAAAGGKKP +  + GG      R QKAA
Sbjct: 268 KTCGGGGEKHRGGGDKKPL--RKNSRWRGQKAAAAGGKKPQKAAAAGGERRKKLRRQKAA 325

Query: 811 AGGKK 815
               K
Sbjct: 326 VARAK 330



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 90/252 (35%), Positives = 112/252 (44%), Gaps = 71/252 (28%)

Query: 586 KTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWR-QKAAGTGAKSRK--------KPWRRG 636
           +TRGGG KQP  QKAA    KSR G+G K   R QKAA  GAKSR         K  RRG
Sbjct: 143 QTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGGVRSLGGKKMRRG 202

Query: 637 QKDAAAAEKAWATGATSRGSGGKQPR--WQKPAAAGSE--SSAAAAVGQEAEARKKPRRR 692
           QK AA A++           GGKQPR   QK + +G     +   A  Q  ++RKK R+R
Sbjct: 203 QKGAAGAKRC---------GGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQR 253

Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSG------------GAKSR 740
                   GQ AA         G++   GK+ GGGG K RG G            G K+ 
Sbjct: 254 --------GQKAAAA-------GQEAAAGKTCGGGGEKHRGGGDKKPLRKNSRWRGQKAA 298

Query: 741 GSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVK 800
            +GG K    +KAAA+     GG +R++                 QKAA A  K P + +
Sbjct: 299 AAGGKKP---QKAAAA-----GGERRKK--------------LRRQKAAVARAKSPKKPR 336

Query: 801 SRGGRGQKAAAG 812
            RG        G
Sbjct: 337 WRGQNSGNGVEG 348



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 75/192 (39%), Positives = 94/192 (48%), Gaps = 23/192 (11%)

Query: 19  GAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAG------GKKAR 72
           GA       + P     ++A     +   GV+ LG G K  R QK AAG      GK+ R
Sbjct: 161 GAKSRGGEGKKPQRRGQKAATAGAKSRGGGVRSLG-GKKMRRGQKGAAGAKRCGGGKQPR 219

Query: 73  LRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE--QKAAAAGT-----KSLGGRGRKPRR 125
            RGQK + +G    Q  QKAA  G    +   +  QKAAAAG      K+ GG G K R 
Sbjct: 220 RRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAGKTCGGGGEKHRG 279

Query: 126 RGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSR 185
            G K      K  RWR QK+AAAG K      QKAAAA G +    +K ++  AA A+++
Sbjct: 280 GGDKKPL--RKNSRWRGQKAAAAGGKK----PQKAAAAGGERR---KKLRRQKAAVARAK 330

Query: 186 SGKKPRRRGAKS 197
           S KKPR RG  S
Sbjct: 331 SPKKPRWRGQNS 342



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 83/217 (38%), Positives = 109/217 (50%), Gaps = 38/217 (17%)

Query: 629 RKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEA-EARK 687
           R +  RR  + AAA E++     T RG  GK+P  Q+   + + S     + Q+A  +  
Sbjct: 84  RGRAQRRSIQAAAAQEQS-----TGRGCLGKEPPSQE---SWTRSDPRRCLSQDAVRSGS 135

Query: 688 KPRRRRAKSRGDGG-----QNAAV-GINPWQRRGKKP-RLGKSRGGGGAKSRGSGGAKSR 740
           +  R R ++RG GG     Q AAV G       GKKP R G+     GAKSRG G    R
Sbjct: 136 RVCRSRPQTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGG---VR 192

Query: 741 GSGGAKSRSGKKAAA-SKSHGGGGAKRRRG------GGAKSRSGEKAVTAG--------- 784
             GG K R G+K AA +K  GGG   RRRG      GG + ++ +KA   G         
Sbjct: 193 SLGGKKMRRGQKGAAGAKRCGGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQ 252

Query: 785 -GQKAAAAGGKKPPRVKSRGGRGQKAAAGG-KKPLRR 819
            GQKAAAA G++    K+ GG G+K   GG KKPLR+
Sbjct: 253 RGQKAAAA-GQEAAAGKTCGGGGEKHRGGGDKKPLRK 288


>gi|239758008 PREDICTED: hypothetical protein XP_002346266 [Homo
           sapiens]
          Length = 316

 Score =  135 bits (340), Expect = 2e-31
 Identities = 120/310 (38%), Positives = 150/310 (48%), Gaps = 83/310 (26%)

Query: 153 RGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS------GKKPRRRGAKSRGD------ 200
           R +    A A   +  +G  + +   AA A+ RS      GK+P  R + +R D      
Sbjct: 68  RDSRVTPATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCIS 127

Query: 201 -EDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQ---KQRRRGQKAA 256
            +  +   R  +SR  +TRGG  KK RR K AA GAKSR  GGKKP+   K RRRGQK+ 
Sbjct: 128 QDASRSGSRVCRSR-PQTRGGGGKKPRRQKDAAAGAKSR--GGKKPRRGRKPRRRGQKST 184

Query: 257 TGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG-RGGRGPKSLGGQN 315
             G     KSRG G KK R+Q                   KPAA G + G G K    ++
Sbjct: 185 AAG----AKSRGEGGKKPRQQ-------------------KPAAAGAKSGLGDK----KS 217

Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ--QKAAVVGVKSRKKQRRRGKKPRRQKA 373
            RWGR  KKP R GQ+A     AG   GGGG+  QKAA  G KS KK RR+ +K   +K 
Sbjct: 218 RRWGR--KKPGRWGQEAV----AGETCGGGGKKPQKAAAPGAKSHKKPRRQWQKAAAEKV 271

Query: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG--GSKKPRRRG 431
           + AGA+S GG                          R QKA AA+ + G  G KK RRRG
Sbjct: 272 AVAGAESCGG--------------------------RGQKAAAARAKSGGFGGKKQRRRG 305

Query: 432 PKAAKSRGGK 441
            +A KSRGG+
Sbjct: 306 QRAPKSRGGR 315



 Score =  130 bits (326), Expect = 6e-30
 Identities = 124/340 (36%), Positives = 151/340 (44%), Gaps = 109/340 (32%)

Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGG 423
           RG+  RR   +AA A+ R  G          RG   K+P    P R +     + PR   
Sbjct: 84  RGRAQRRSMHAAA-AQERSLG----------RGCLGKEP----PNRESWTR--SDPRHCI 126

Query: 424 SKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAG 483
           S+   R G +  +SR  ++R GGGKKPRR                        QK +AAG
Sbjct: 127 SQDASRSGSRVCRSRP-QTRGGGGKKPRR------------------------QKDAAAG 161

Query: 484 TKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR--KQPRRQKPAVAGAKSRVG 541
            KSRGG           RRG+K    G+K+TAAGAKSRG   K+PR+QKPA AGAKS   
Sbjct: 162 AKSRGGKKP--------RRGRKPRRRGQKSTAAGAKSRGEGGKKPRQQKPAAAGAKS--- 210

Query: 542 GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
                              G G+K+SR  G  KP +WGQ A A +T GGG K+P      
Sbjct: 211 -------------------GLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGKKP------ 245

Query: 602 AGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQP 661
                            QKAA  GAKS KKP R+ QK  AAAEK    GA S G  G   
Sbjct: 246 -----------------QKAAAPGAKSHKKPRRQWQK--AAAEKVAVAGAESCGGRG--- 283

Query: 662 RWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
             QK AAA ++S       Q    ++ P     KSRG  G
Sbjct: 284 --QKAAAARAKSGGFGGKKQRRRGQRAP-----KSRGGRG 316



 Score =  108 bits (270), Expect = 2e-23
 Identities = 100/261 (38%), Positives = 134/261 (51%), Gaps = 41/261 (15%)

Query: 100 NRGGGEQK---AAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAG 156
           +RG  +++   AAAA  +SLG RG   +    + + T S      +Q ++ +GS+   + 
Sbjct: 83  HRGRAQRRSMHAAAAQERSLG-RGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSR 141

Query: 157 AQKAAAAAGVKSQGGEKP--QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF 214
            Q        +  GG+KP  QK AAAGAKSR GKKP RRG K R    ++G++  A    
Sbjct: 142 PQ-------TRGGGGKKPRRQKDAAAGAKSRGGKKP-RRGRKPR----RRGQKSTAAG-- 187

Query: 215 GKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKL 274
            K+RG   KK R+ KPAA GAKS  G G K  ++  R +    G ++  G++ GGG KK 
Sbjct: 188 AKSRGEGGKKPRQQKPAAAGAKS--GLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGKK- 244

Query: 275 RRQGQNAALAGAK------RRGAATAGEKPAAKGR---GGRGPKSLGGQNPRWGRGGKKP 325
               Q AA  GAK      R+    A EK A  G    GGRG K+   +    G GGKK 
Sbjct: 245 ---PQKAAAPGAKSHKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAARAKSGGFGGKKQ 301

Query: 326 RRRGQKATKAAAAGTKRGGGG 346
           RRRGQ+A K+      RGG G
Sbjct: 302 RRRGQRAPKS------RGGRG 316



 Score =  101 bits (251), Expect = 3e-21
 Identities = 86/219 (39%), Positives = 109/219 (49%), Gaps = 45/219 (20%)

Query: 599 KAAAGVTKSRS---GDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDAAAAEKAWATGATS 653
           ++ + V +SR    G GGKK  RQK A  GAKSR  KKP RRG+K     +K+ A GA S
Sbjct: 132 RSGSRVCRSRPQTRGGGGKKPRRQKDAAAGAKSRGGKKP-RRGRKPRRRGQKSTAAGAKS 190

Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR 713
           RG GGK+PR QKPAAAG++S             KK RR   K  G  GQ A  G      
Sbjct: 191 RGEGGKKPRQQKPAAAGAKSGLGD---------KKSRRWGRKKPGRWGQEAVAG------ 235

Query: 714 RGKKPRLGKSRGGGGAKSRGSG--GAKSRGSGGAKSRSGKKAAASKSHGGG----GAKRR 767
                   ++ GGGG K + +   GAKS        R  +KAAA K    G    G + +
Sbjct: 236 --------ETCGGGGKKPQKAAAPGAKSHKK---PRRQWQKAAAEKVAVAGAESCGGRGQ 284

Query: 768 RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
           +   A+++SG      GG+K    G + P   KSRGGRG
Sbjct: 285 KAAAARAKSG----GFGGKKQRRRGQRAP---KSRGGRG 316



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 100/275 (36%), Positives = 124/275 (45%), Gaps = 54/275 (19%)

Query: 326 RRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGD 385
           R R Q+ +  AAA  +R  G       +G +   ++      PR   +  A   SR G  
Sbjct: 84  RGRAQRRSMHAAAAQERSLG----RGCLGKEPPNRESWTRSDPRHCISQDA---SRSGSR 136

Query: 386 KKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG----GSKKPRRRGPKAAKSRGGK 441
               R   R G G+K      PRR+   A  AK RGG      +KPRRRG K+  + G K
Sbjct: 137 VCRSRPQTRGGGGKK------PRRQKDAAAGAKSRGGKKPRRGRKPRRRGQKST-AAGAK 189

Query: 442 SRSGGGKKPRRRGQKARQKAAEAGAES-RGDKKQ---GRQKASAAGTKSRGGGLKSHSGK 497
           SR  GGKKPR      +QK A AGA+S  GDKK    GR+K    G ++  G      GK
Sbjct: 190 SRGEGGKKPR------QQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGK 243

Query: 498 NLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKS--RQRQKAVAAG 555
                        +KA A GAKS   K+PRRQ    A  K  V G++S   + QKA AA 
Sbjct: 244 K-----------PQKAAAPGAKS--HKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAAR 290

Query: 556 ATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG 590
           A S G GG KQ R G             A K+RGG
Sbjct: 291 AKSGGFGGKKQRRRG-----------QRAPKSRGG 314



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 96/281 (34%), Positives = 129/281 (45%), Gaps = 77/281 (27%)

Query: 25  ALARTPVELAAESAAPALSAAAAGVKILGSG---------------DKK--LRRQKAAAG 67
           A A  P+     +   ++ AAAA  + LG G               D +  + +  + +G
Sbjct: 75  ATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSG 134

Query: 68  GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRG 127
            +  R R Q     GK+ R+    AA   GA++RGG + +           RGRKPRRRG
Sbjct: 135 SRVCRSRPQTRGGGGKKPRRQKDAAA---GAKSRGGKKPR-----------RGRKPRRRG 180

Query: 128 QKAAATGSKK-----PRWRAQKSAAAGSKNRGAGAQKA--------------AAAAGVKS 168
           QK+ A G+K       + R QK AAAG+K+ G G +K+              A A     
Sbjct: 181 QKSTAAGAKSRGEGGKKPRQQKPAAAGAKS-GLGDKKSRRWGRKKPGRWGQEAVAGETCG 239

Query: 169 QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRP 228
            GG+KPQKAAA GAKS   KKPRR+  K+  +        +      ++ GGR +     
Sbjct: 240 GGGKKPQKAAAPGAKSH--KKPRRQWQKAAAE--------KVAVAGAESCGGRGQ----- 284

Query: 229 KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGG 269
           K AA  AKS   GGK   KQRRRGQ+A         KSRGG
Sbjct: 285 KAAAARAKSGGFGGK---KQRRRGQRAP--------KSRGG 314



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 89/249 (35%), Positives = 106/249 (42%), Gaps = 85/249 (34%)

Query: 616 AWRQKAAGTGAKSRKKP----WRRGQKDAAAAEKAWATGAT-------SRGSGGKQPRWQ 664
           A ++++ G G   ++ P    W R       ++ A  +G+        +RG GGK+PR Q
Sbjct: 96  AAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQTRGGGGKKPRRQ 155

Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSR 724
           K AAAG                       AKSRG                GKKPR G+  
Sbjct: 156 KDAAAG-----------------------AKSRG----------------GKKPRRGRKP 176

Query: 725 GGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAK-SRSGEKAV-- 781
              G KS  +G AKSRG GG K R  K AAA    G G  K RR G  K  R G++AV  
Sbjct: 177 RRRGQKSTAAG-AKSRGEGGKKPRQQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAG 235

Query: 782 -TAGG-----QKAAAAGGK--KPPR---------------VKSRGGRGQKAAA------- 811
            T GG     QKAAA G K  K PR                +S GGRGQKAAA       
Sbjct: 236 ETCGGGGKKPQKAAAPGAKSHKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAARAKSGG 295

Query: 812 -GGKKPLRR 819
            GGKK  RR
Sbjct: 296 FGGKKQRRR 304



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 62/149 (41%), Positives = 79/149 (53%), Gaps = 20/149 (13%)

Query: 44  AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
           + AAG K  G G KK R+QK AA G K+ L  +K    G++    W + A AG  E  GG
Sbjct: 183 STAAGAKSRGEGGKKPRQQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAG--ETCGG 240

Query: 104 G---EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
           G    QKAAA G KS     +KPRR+ QKAA          A+K A AG+++ G   QKA
Sbjct: 241 GGKKPQKAAAPGAKS----HKKPRRQWQKAA----------AEKVAVAGAESCGGRGQKA 286

Query: 161 AAA-AGVKSQGGEKPQKAAAAGAKSRSGK 188
           AAA A     GG+K ++      KSR G+
Sbjct: 287 AAARAKSGGFGGKKQRRRGQRAPKSRGGR 315


>gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo
           sapiens]
          Length = 351

 Score =  127 bits (319), Expect = 4e-29
 Identities = 106/265 (40%), Positives = 135/265 (50%), Gaps = 54/265 (20%)

Query: 369 RRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR---WQNPRRRAQKAPAAKP--RGGG 423
           R  +A+ A A S G G + G    +R    R  PR   +Q+  R   +   ++P  RGGG
Sbjct: 83  RSMQATVAKAGSPGRG-RLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGG 141

Query: 424 SKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAG 483
            KKPRRRG KAAKSRG     GGGKKPR       QKAA AGA+     ++  ++A+AAG
Sbjct: 142 DKKPRRRGQKAAKSRG-----GGGKKPR------GQKAAGAGAKKHRKPRRRGERAAAAG 190

Query: 484 TK--SRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVG 541
            K   +    KS  G             G+K  AAG K     +PRR++   A AKSR G
Sbjct: 191 GKKLQKAAAAKSRGG------------GGKKTAAAGGK-----KPRRRRGQKA-AKSRGG 232

Query: 542 GSKSRQRQKAVAAGATSHGG-----GGNKQ--------SRGGGGNKPRQWGQTAAAAKTR 588
           G K  +RQKA   G  S G      GG KQ        SRGGGG KP++    AA AK+R
Sbjct: 233 GDKKLERQKAALTGVKSRGDKKPLRGGKKQRERGQNTKSRGGGGEKPQK--AAAAGAKSR 290

Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGG 613
           GG  ++P  QKA AG  ++R  + G
Sbjct: 291 GGRGEKP--QKAEAGQGQNRRNEVG 313



 Score =  124 bits (312), Expect = 3e-28
 Identities = 115/309 (37%), Positives = 146/309 (47%), Gaps = 80/309 (25%)

Query: 109 AAAGTKSLGGRGRKPRRRG------------QKAAATGSKKPRWRAQKSAAAGSKNRGAG 156
           A AG+   G  G++PRRR             Q A+  GS+  R R Q       K R  G
Sbjct: 90  AKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRG 149

Query: 157 AQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGK 216
            QKAA + G    GG+KP+   AAGA ++  +KPRRRG ++     KK ++  A     K
Sbjct: 150 -QKAAKSRG---GGGKKPRGQKAAGAGAKKHRKPRRRGERAAAAGGKKLQKAAA----AK 201

Query: 217 TRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
           +RGG            GG K+   GGKKP+  RRRGQKAA        KSRGGGDKKL R
Sbjct: 202 SRGG------------GGKKTAAAGGKKPR--RRRGQKAA--------KSRGGGDKKLER 239

Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
           Q   AAL G K RG     +KP                     RGGKK R RGQ  TK+ 
Sbjct: 240 Q--KAALTGVKSRG----DKKPL--------------------RGGKKQRERGQN-TKS- 271

Query: 337 AAGTKRGGGGQ--QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
                RGGGG+  QKAA  G KSR     RG+KP++ +A     +    G +  L   + 
Sbjct: 272 -----RGGGGEKPQKAAAAGAKSRGG---RGEKPQKAEAGQGQNRRNEVGGQHNLALLEC 323

Query: 395 RGDGRKKPR 403
              G+ +P+
Sbjct: 324 DVIGKVQPK 332



 Score =  119 bits (297), Expect = 1e-26
 Identities = 95/245 (38%), Positives = 126/245 (51%), Gaps = 43/245 (17%)

Query: 34  AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
           +A    P   A+ AG ++  S     R Q    G KK R RGQK A           K+ 
Sbjct: 113 SAPRRCPYQDASRAGSRVCRS-----RPQNRGGGDKKPRRRGQKAA-----------KSR 156

Query: 94  GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
           G GG + RG   QKAA AG K    + RKPRRRG++AAA G KK     QK+AAA  K+R
Sbjct: 157 GGGGKKPRG---QKAAGAGAK----KHRKPRRRGERAAAAGGKK----LQKAAAA--KSR 203

Query: 154 GAGAQKAAAAAGVKSQG--GEKPQKAAAAGAKSRSGKKPRRRGAKSRGDED--KKGRQRE 209
           G G +K AAA G K +   G+K  K+   G K    +K    G KSRGD+   + G+++ 
Sbjct: 204 GGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRGGKKQR 263

Query: 210 AKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGG 269
            + +  K+RGG  +K +  K AA GAKSR G G+KPQK        A  G+ +  ++  G
Sbjct: 264 ERGQNTKSRGGGGEKPQ--KAAAAGAKSRGGRGEKPQK--------AEAGQGQNRRNEVG 313

Query: 270 GDKKL 274
           G   L
Sbjct: 314 GQHNL 318



 Score =  114 bits (286), Expect = 3e-25
 Identities = 108/298 (36%), Positives = 137/298 (45%), Gaps = 58/298 (19%)

Query: 248 QRRRGQ----KAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGR 303
           QRR  Q    KA + G+ R+GK     +   R   +      A R G+     +P  +G 
Sbjct: 81  QRRSMQATVAKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGG 140

Query: 304 GGRGPKSLGGQNPRW-GRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQR 362
           G + P+  G +  +  G GGKKPR  GQKA  A                  G K  +K R
Sbjct: 141 GDKKPRRRGQKAAKSRGGGGKKPR--GQKAAGA------------------GAKKHRKPR 180

Query: 363 RRGKKPR----RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAK 418
           RRG++      ++   AA AKSRGGG K      K    G KKPR    RRR QK  AAK
Sbjct: 181 RRGERAAAAGGKKLQKAAAAKSRGGGGK------KTAAAGGKKPR----RRRGQK--AAK 228

Query: 419 PRGGGSKKPRRRGPKAA----KSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
            RGGG KK  R+  KAA    KSRG K    GGKK R RGQ  +         SRG   +
Sbjct: 229 SRGGGDKKLERQ--KAALTGVKSRGDKKPLRGGKKQRERGQNTK---------SRGGGGE 277

Query: 475 GRQKASAAGTKSRGG-GLKSHSGKNLWRRGQKAEAAGEKATA-AGAKSRGRKQPRRQK 530
             QKA+AAG KSRGG G K    +    + ++ E  G+   A       G+ QP+ +K
Sbjct: 278 KPQKAAAAGAKSRGGRGEKPQKAEAGQGQNRRNEVGGQHNLALLECDVIGKVQPKTKK 335



 Score =  113 bits (283), Expect = 6e-25
 Identities = 124/319 (38%), Positives = 137/319 (42%), Gaps = 107/319 (33%)

Query: 506 AEAAGEKATAAGAKSRGR----KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGG 561
           A+    +AT A A S GR    K+PRR++     A  R         Q A  AG  S   
Sbjct: 80  AQRRSMQATVAKAGSPGRGRLGKEPRRRESWTRSAPRRC------PYQDASRAG--SRVC 131

Query: 562 GGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKA 621
               Q+RGGG  KPR+ GQ AA  K+RGGG                     GKK   QKA
Sbjct: 132 RSRPQNRGGGDKKPRRRGQKAA--KSRGGG---------------------GKKPRGQKA 168

Query: 622 AGTGAKSRKKPWRRGQKDAAAAEKAW--ATGATSRGSGGKQPRWQKPAAAGSESSAAAAV 679
           AG GAK  +KP RRG++ AAA  K    A  A SRG GGK     K AAAG         
Sbjct: 169 AGAGAKKHRKPRRRGERAAAAGGKKLQKAAAAKSRGGGGK-----KTAAAGG-------- 215

Query: 680 GQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKS 739
                  KKPRRRR       GQ AA                KSRGGG  K      A +
Sbjct: 216 -------KKPRRRR-------GQKAA----------------KSRGGGDKKLERQKAALT 245

Query: 740 RGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGG---QKAAAAGGKKP 796
               G KSR  KK        GG  +R RG   KSR G      GG   QKAAAAG    
Sbjct: 246 ----GVKSRGDKKPLR-----GGKKQRERGQNTKSRGG------GGEKPQKAAAAG---- 286

Query: 797 PRVKSRGGRG---QKAAAG 812
              KSRGGRG   QKA AG
Sbjct: 287 --AKSRGGRGEKPQKAEAG 303



 Score =  109 bits (272), Expect = 1e-23
 Identities = 106/252 (42%), Positives = 129/252 (51%), Gaps = 55/252 (21%)

Query: 315 NPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRG-KKPRRQKA 373
           +P  GR GK+PRRR +  T++A          +  + V   +SR + R  G KKPRR+  
Sbjct: 94  SPGRGRLGKEPRRR-ESWTRSAPRRCPYQDASRAGSRVC--RSRPQNRGGGDKKPRRRGQ 150

Query: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
            AA  KSRGGG KK  R  K  G G KK R   PRRR ++A AA     G KK ++    
Sbjct: 151 KAA--KSRGGGGKKP-RGQKAAGAGAKKHR--KPRRRGERAAAA-----GGKKLQKAA-- 198

Query: 434 AAKSRGG---KSRSGGGKKPRRR-GQKA------------RQKAAEAGAESRGDKKQGR- 476
           AAKSRGG   K+ + GGKKPRRR GQKA            RQKAA  G +SRGDKK  R 
Sbjct: 199 AAKSRGGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRG 258

Query: 477 ---QKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAV 533
              Q+     TKSRGGG           + QKA        AAGAKSRG +  + QK   
Sbjct: 259 GKKQRERGQNTKSRGGG---------GEKPQKAA-------AAGAKSRGGRGEKPQKAEA 302

Query: 534 AGAKSR---VGG 542
              ++R   VGG
Sbjct: 303 GQGQNRRNEVGG 314



 Score =  101 bits (252), Expect = 2e-21
 Identities = 91/251 (36%), Positives = 125/251 (49%), Gaps = 61/251 (24%)

Query: 231 AAGGAKSRRGGGKKPQKQ--------RRRGQKAATGGKSRVGKSR----GGGDKKLRRQG 278
           A  G+  R   GK+P+++        RR   + A+   SRV +SR    GGGDKK RR+G
Sbjct: 90  AKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRG 149

Query: 279 QNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKA--- 335
           Q AA    K RG    G+KP  +   G G K             +KPRRRG++A  A   
Sbjct: 150 QKAA----KSRGGG--GKKPRGQKAAGAGAKK-----------HRKPRRRGERAAAAGGK 192

Query: 336 ----AAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR--------RQKASAAGAKSRGG 383
               AAA   RGGGG++ AA  G K R+++ ++  K R        RQKA+  G KSRG 
Sbjct: 193 KLQKAAAAKSRGGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRG- 251

Query: 384 GDKKGLREAKRRGDGRKKPRWQNPRRRA------QKAPA--AKPRGGGSKKPRRRGPKAA 435
            DKK LR  K++     + R QN + R       QKA A  AK RGG  +KP++   +A 
Sbjct: 252 -DKKPLRGGKKQ-----RERGQNTKSRGGGGEKPQKAAAAGAKSRGGRGEKPQK--AEAG 303

Query: 436 KSRGGKSRSGG 446
           + +  ++  GG
Sbjct: 304 QGQNRRNEVGG 314



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 87/233 (37%), Positives = 109/233 (46%), Gaps = 37/233 (15%)

Query: 482 AGTKSRGGGLKSHSGKNLWRRG-------QKAEAAGEKATAAGAKSRGRKQPRRQKPAVA 534
           AG+  RG   K    +  W R        Q A  AG +   +  ++RG    + ++    
Sbjct: 92  AGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRGQK 151

Query: 535 GAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSR--GGGGNKPRQWGQTAAAAKTRGGGD 592
            AKSR GG K  + QKA  AGA  H     +  R    GG K     Q AAAAK+RGGG 
Sbjct: 152 AAKSRGGGGKKPRGQKAAGAGAKKHRKPRRRGERAAAAGGKKL----QKAAAAKSRGGGG 207

Query: 593 KQPGWQKAAAGVTKSR----------SGDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDA 640
           K    + AAAG  K R           G G KK  RQKAA TG KSR  KKP R G+K  
Sbjct: 208 K----KTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRGGKK-- 261

Query: 641 AAAEKAWATGATSRGSGGKQPRWQKPAAAGSES-SAAAAVGQEAEARKKPRRR 692
              ++       SRG GG++P  QK AAAG++S        Q+AEA +   RR
Sbjct: 262 ---QRERGQNTKSRGGGGEKP--QKAAAAGAKSRGGRGEKPQKAEAGQGQNRR 309



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 72/167 (43%), Positives = 85/167 (50%), Gaps = 37/167 (22%)

Query: 666 PAAAGSESSAAAAVGQEAEAR--KKPRRRRAKSRGDGGQNAAVGINPWQ---RRGKKPRL 720
           PA   S  +  A  G     R  K+PRRR + +R      +A    P+Q   R G +   
Sbjct: 79  PAQRRSMQATVAKAGSPGRGRLGKEPRRRESWTR------SAPRRCPYQDASRAGSRVCR 132

Query: 721 GK--SRGGGGAK--SRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRS 776
            +  +RGGG  K   RG   AKSRG GG K R G+KAA      G GAK+ R      R 
Sbjct: 133 SRPQNRGGGDKKPRRRGQKAAKSRGGGGKKPR-GQKAA------GAGAKKHR---KPRRR 182

Query: 777 GEKAVTAGG---QKAAAAGGKKPPRVKSRGGRGQK-AAAGGKKPLRR 819
           GE+A  AGG   QKAAAA        KSRGG G+K AAAGGKKP RR
Sbjct: 183 GERAAAAGGKKLQKAAAA--------KSRGGGGKKTAAAGGKKPRRR 221


>gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo
           sapiens]
          Length = 321

 Score =  122 bits (306), Expect = 1e-27
 Identities = 109/287 (37%), Positives = 138/287 (48%), Gaps = 64/287 (22%)

Query: 364 RGKKPRRQ-KASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG 422
           RG+  RR  +A+AA  +S G G             G++ P+W++  R         PR  
Sbjct: 84  RGQVQRRSMQAAAAQEQSLGRGCL-----------GKEPPKWESSTRSG-------PRRC 125

Query: 423 GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
            S+   R G +  +SR  ++R GGGKKPRR                        QKA+ A
Sbjct: 126 LSQDASRSGSRVCRSRP-QTRGGGGKKPRRG-----------------------QKAATA 161

Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
           G KSRGGG++S  GK + RRGQKA        AAGAKS G    + QK    GA+ R G 
Sbjct: 162 GAKSRGGGVRSRGGKKIRRRGQKA-------AAAGAKSCGGGGKKPQKARAVGARRR-GW 213

Query: 543 SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGD--KQPGWQKA 600
            K R+R K  AA      G   +Q    G  KPR+ GQ AAAA    GG+  K+P  QKA
Sbjct: 214 KKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQKAAAA----GGERCKKPRRQKA 269

Query: 601 AAGVTKSRSGDGGKKAWRQ--KAAGTGAKSRKKPWRRGQKDAAAAEK 645
           AA   KS      KK  R+   +A  GA+SRK P RRGQK  AA  +
Sbjct: 270 AAVSAKS-----PKKPRRRVLNSARLGAESRKNPQRRGQKSMAAKSR 311



 Score =  109 bits (272), Expect = 1e-23
 Identities = 114/290 (39%), Positives = 134/290 (46%), Gaps = 75/290 (25%)

Query: 221 RRKKHRRPKPAAGGAKSRRGGG---KKPQK---------QRRRGQKAATGGKSRVGKSR- 267
           R +  RR   AA   +   G G   K+P K         +R   Q A+  G SRV +SR 
Sbjct: 84  RGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSG-SRVCRSRP 142

Query: 268 ---GGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
              GGG KK RR GQ AA AGAK RG                             RGGKK
Sbjct: 143 QTRGGGGKKPRR-GQKAATAGAKSRGGGVRS------------------------RGGKK 177

Query: 325 PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR--KKQRRRGKKPRRQKASAAGAKSRG 382
            RRRGQKA  A A     GG   QKA  VG + R  KK RRRGK     KA+AA      
Sbjct: 178 IRRRGQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGK-----KAAAA------ 226

Query: 383 GGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKS 442
           GG+K G +  ++   GRKK     PRRR QKA AA   G   KKPRR+   A  ++    
Sbjct: 227 GGEKAGKKLRQQGEKGRKK-----PRRRGQKAAAA--GGERCKKPRRQKAAAVSAK---- 275

Query: 443 RSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLK 492
                KKPRRR       +A  GAESR + ++  QK+ AA  KSR G  K
Sbjct: 276 ---SPKKPRRR----VLNSARLGAESRKNPQRRGQKSMAA--KSRVGSGK 316



 Score =  103 bits (256), Expect = 8e-22
 Identities = 98/273 (35%), Positives = 125/273 (45%), Gaps = 54/273 (19%)

Query: 469 RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR 528
           RG  ++   +A+AA  +S G G         W   + +  +G +   +   SR   +  R
Sbjct: 84  RGQVQRRSMQAAAAQEQSLGRGCLGKEPPK-W---ESSTRSGPRRCLSQDASRSGSRVCR 139

Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA--K 586
            +P   G     GG K R+ QKA  AGA S GGG     R  GG K R+ GQ AAAA  K
Sbjct: 140 SRPQTRGG----GGKKPRRGQKAATAGAKSRGGG----VRSRGGKKIRRRGQKAAAAGAK 191

Query: 587 TRGGGDKQP-----------GWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
           + GGG K+P           GW+K      K+ +  GG+KA + K    G K RKKP RR
Sbjct: 192 SCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAA-GGEKAGK-KLRQQGEKGRKKPRRR 249

Query: 636 GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK 695
           GQK AAA            G   K+PR QK AA  ++S             KKPRRR   
Sbjct: 250 GQKAAAAG-----------GERCKKPRRQKAAAVSAKSP------------KKPRRRVLN 286

Query: 696 SRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG 728
           S   G ++     NP QRRG+K    KSR G G
Sbjct: 287 SARLGAESRK---NP-QRRGQKSMAAKSRVGSG 315



 Score =  101 bits (251), Expect = 3e-21
 Identities = 84/245 (34%), Positives = 114/245 (46%), Gaps = 42/245 (17%)

Query: 1   MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
           + +RG  Q       A     LG   L + P +  + + +      +      GS   + 
Sbjct: 81  LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRS 140

Query: 60  RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE-----QKAAAAGTK 114
           R Q    GGKK R RGQK A AG ++R         GG  +RGG +     QKAAAAG K
Sbjct: 141 RPQTRGGGGKKPR-RGQKAATAGAKSR--------GGGVRSRGGKKIRRRGQKAAAAGAK 191

Query: 115 SLGGRGRKP----------------RRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQ 158
           S GG G+KP                RRRG+KAAA G +K   + ++    G K      Q
Sbjct: 192 SCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQ 251

Query: 159 KAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRR-------GAKSRGDEDKKG-RQREA 210
           KAAAA G +    +KP++  AA   ++S KKPRRR       GA+SR +  ++G +   A
Sbjct: 252 KAAAAGGERC---KKPRRQKAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQKSMAA 308

Query: 211 KSRFG 215
           KSR G
Sbjct: 309 KSRVG 313



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 95/297 (31%), Positives = 123/297 (41%), Gaps = 87/297 (29%)

Query: 116 LGGRGRKPRRRGQKAAAT---------GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGV 166
           L  RG+  RR  Q AAA          G + P+W +    +  S  R   +Q A+ +   
Sbjct: 81  LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWES----STRSGPRRCLSQDASRSGSR 136

Query: 167 KSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHR 226
             +   +PQ     G K R G+K    GAKSRG   +             +RGG++ + R
Sbjct: 137 VCRS--RPQTRGGGGKKPRRGQKAATAGAKSRGGGVR-------------SRGGKKIRRR 181

Query: 227 RPKPAAGGAKSRRGGGKKPQKQR-------------RRGQKAATGGKSRVGKSRGG---- 269
             K AA GAKS  GGGKKPQK R             RRG+KAA  G  + GK        
Sbjct: 182 GQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEK 241

Query: 270 GDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRG 329
           G KK RR+GQ AA AG +R                                  KKPRR  
Sbjct: 242 GRKKPRRRGQKAAAAGGER---------------------------------CKKPRR-- 266

Query: 330 QKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDK 386
           QKA   +A   K+       +A +G +SRK  +RRG+K       +  AKSR G  K
Sbjct: 267 QKAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQK-------SMAAKSRVGSGK 316



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 101/288 (35%), Positives = 135/288 (46%), Gaps = 66/288 (22%)

Query: 42  LSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENR 101
           ++ A A + +   G  + R  +AAA  +++  RG      GKE  + W+ +  +G    R
Sbjct: 72  VTPATALLLLSHRGQVQRRSMQAAAAQEQSLGRG----CLGKEPPK-WESSTRSGP---R 123

Query: 102 GGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
               Q A+ +G++    R   P+ RG      G KKPR R QK+A AG+K+RG G     
Sbjct: 124 RCLSQDASRSGSRVCRSR---PQTRGG-----GGKKPR-RGQKAATAGAKSRGGG----- 169

Query: 162 AAAGVKSQGGEK----PQKAAAAGAKS--RSGKKPRRRGAKSRGDEDKKGRQREAKSRFG 215
               V+S+GG+K     QKAAAAGAKS    GKKP++  A                   G
Sbjct: 170 ----VRSRGGKKIRRRGQKAAAAGAKSCGGGGKKPQKARA------------------VG 207

Query: 216 KTRGGRRKKHRRPKPAAG------GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR-- 267
             R G +K  RR K AA       G K R+ G K  +K RRRGQKAA  G  R  K R  
Sbjct: 208 ARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQKAAAAGGERCKKPRRQ 267

Query: 268 ------GGGDKKLRRQGQNAALAGAK-RRGAATAGEKP-AAKGRGGRG 307
                     KK RR+  N+A  GA+ R+     G+K  AAK R G G
Sbjct: 268 KAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQKSMAAKSRVGSG 315



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 71/202 (35%), Positives = 97/202 (48%), Gaps = 39/202 (19%)

Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARKKPRRR 692
           RR  + AAA E++   G      G + P+W+    +G        + Q+A  +  +  R 
Sbjct: 89  RRSMQAAAAQEQSLGRGCL----GKEPPKWESSTRSGPRR----CLSQDASRSGSRVCRS 140

Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKK 752
           R ++RG GG              KKPR G+     GAKSRG GG +SRG    + R  K 
Sbjct: 141 RPQTRGGGG--------------KKPRRGQKAATAGAKSRG-GGVRSRGGKKIRRRGQKA 185

Query: 753 AAA-SKSHGGGGAK--RRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRG------ 803
           AAA +KS GGGG K  + R  GA+ R  +K    G + AAA G K   +++ +G      
Sbjct: 186 AAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKK 245

Query: 804 --GRGQKAAAGG----KKPLRR 819
              RGQKAAA G    KKP R+
Sbjct: 246 PRRRGQKAAAAGGERCKKPRRQ 267



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 53/172 (30%), Positives = 73/172 (42%), Gaps = 44/172 (25%)

Query: 657 GGKQPRWQKPAAAGSESSAAAAVGQE-----AEARKKPRRRRAKSRGDGGQNAAVGINPW 711
           G  Q R  + AAA  +S     +G+E     +  R  PRR  ++     G          
Sbjct: 85  GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGS--------- 135

Query: 712 QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGG 771
                  R+ +SR             ++RG GG K R G+KAA + +   GG  R RGG 
Sbjct: 136 -------RVCRSR------------PQTRGGGGKKPRRGQKAATAGAKSRGGGVRSRGGK 176

Query: 772 AKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG----------RGQKAAAGG 813
              R G+KA  AG  K+   GGKKP + ++ G           RG+KAAA G
Sbjct: 177 KIRRRGQKAAAAGA-KSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAG 227


>gi|239741651 PREDICTED: hypothetical protein XP_002342270 [Homo
           sapiens]
          Length = 337

 Score =  115 bits (287), Expect = 2e-25
 Identities = 102/278 (36%), Positives = 130/278 (46%), Gaps = 51/278 (18%)

Query: 286 AKRRG--AATAGEKPAAKGRGGRGP--KSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
           A+RR   AA A E+   + R G+ P  +    ++  W    +   R G +     ++   
Sbjct: 80  AQRRSMRAAAAQERSPGRRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQV--CGSSPQT 137

Query: 342 RGGGGQ----QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD 397
           RGGGG+    QKA V+G KSRKK +  G     QKA+ AGAKS GGG KK          
Sbjct: 138 RGGGGKKLQRQKATVMGAKSRKKPQHWG-----QKAATAGAKSPGGGGKK---------- 182

Query: 398 GRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR--------GGKSRSGGGKK 449
               P  + P    +K  AAK RGGG KKPRR  P AA ++        G K R  GG+K
Sbjct: 183 ----PGQEKPAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRK 238

Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKA--E 507
           PR RG    QKA EAGA+SRG      QK +AAG        K H GK   RRGQ +   
Sbjct: 239 PRWRG----QKATEAGAKSRGGGGIKPQKPAAAGA-------KIHGGKKPRRRGQSSGNG 287

Query: 508 AAGEKATA-AGAKSRGRKQPRRQKPAVAGAKSRVGGSK 544
             G+ + A       G+ Q +  K       SR  GS+
Sbjct: 288 VEGQNSLAFLECDVEGKVQRKTNKDNPRRESSRCTGSQ 325



 Score =  110 bits (276), Expect = 4e-24
 Identities = 77/163 (47%), Positives = 92/163 (56%), Gaps = 35/163 (21%)

Query: 53  GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGG-----EQK 107
           G G KKL+RQKA   G K+R + Q           HW + A   GA++ GGG     ++K
Sbjct: 139 GGGGKKLQRQKATVMGAKSRKKPQ-----------HWGQKAATAGAKSPGGGGKKPGQEK 187

Query: 108 AAAAG-----TKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA-- 160
            AA G      KS GG G+KPRR  +K AA G+K P    QK+AAAG+K R AG +K   
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRR--EKPAAAGAKNP----QKAAAAGAKFREAGGRKPRW 241

Query: 161 ----AAAAGVKSQGGE--KPQKAAAAGAKSRSGKKPRRRGAKS 197
               A  AG KS+GG   KPQK AAAGAK   GKKPRRRG  S
Sbjct: 242 RGQKATEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRRGQSS 284



 Score =  106 bits (265), Expect = 8e-23
 Identities = 94/285 (32%), Positives = 132/285 (46%), Gaps = 39/285 (13%)

Query: 141 RAQKSA--AAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSR 198
           RAQ+ +  AA ++ R  G ++      ++            +    R+G +      ++R
Sbjct: 79  RAQRRSMRAAAAQERSPGRRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQVCGSSPQTR 138

Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATG 258
           G   KK ++++A     K+R  ++ +H   K A  GAKS  GGGKKP +++     AATG
Sbjct: 139 GGGGKKLQRQKATVMGAKSR--KKPQHWGQKAATAGAKSPGGGGKKPGQEK----PAATG 192

Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW 318
            K+R  KSRGGG KK RR  +  A AGAK        +K AA G   R            
Sbjct: 193 EKTRAAKSRGGGGKKPRR--EKPAAAGAKN------PQKAAAAGAKFR------------ 232

Query: 319 GRGGKKPRRRGQKATKAAAAGTKRGGGG--QQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
             GG+KPR RGQKAT+A A    RGGGG   QK A  G K        GKKPRR+  S+ 
Sbjct: 233 EAGGRKPRWRGQKATEAGA--KSRGGGGIKPQKPAAAGAKI-----HGGKKPRRRGQSSG 285

Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
                 G +     E    G  ++K    NPRR + +   ++  G
Sbjct: 286 NGVE--GQNSLAFLECDVEGKVQRKTNKDNPRRESSRCTGSQVLG 328



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 70/168 (41%), Positives = 86/168 (51%), Gaps = 15/168 (8%)

Query: 603 GVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPR 662
           G +    G GGKK  RQKA   GAKSRKKP   GQK A A       GA S G GGK+P 
Sbjct: 132 GSSPQTRGGGGKKLQRQKATVMGAKSRKKPQHWGQKAATA-------GAKSPGGGGKKPG 184

Query: 663 WQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRG--DGGQNAAVGINPWQRRGKKPR- 719
            +KPAA G ++ AA + G      KKPRR +  + G  +  + AA G    +  G+KPR 
Sbjct: 185 QEKPAATGEKTRAAKSRG---GGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRKPRW 241

Query: 720 LGKSRGGGGAKSRGSGGAKSR--GSGGAKSRSGKKAAASKSHGGGGAK 765
            G+     GAKSRG GG K +   + GAK   GKK        G G +
Sbjct: 242 RGQKATEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRRGQSSGNGVE 289



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 89/271 (32%), Positives = 118/271 (43%), Gaps = 75/271 (27%)

Query: 453 RGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEK 512
           R Q+   +AA A   S G ++ G++                   +  W R        + 
Sbjct: 79  RAQRRSMRAAAAQERSPGRRRLGKEPLI----------------RESWTRSAPWRCLSQD 122

Query: 513 ATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGG 572
           A  AG++  G           +  ++R GG K  QRQKA   GA S              
Sbjct: 123 AGRAGSQVCG-----------SSPQTRGGGGKKLQRQKATVMGAKSR------------- 158

Query: 573 NKPRQWGQTAAAA--KTRGGGDKQPGWQKAAAG-----VTKSRSGDGGKKAWRQKAAGTG 625
            KP+ WGQ AA A  K+ GGG K+PG +K AA        KSR G GGKK  R+K A  G
Sbjct: 159 KKPQHWGQKAATAGAKSPGGGGKKPGQEKPAATGEKTRAAKSRGG-GGKKPRREKPAAAG 217

Query: 626 AKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRW--QKPAAAGSESSAA------- 676
           AK+               +KA A GA  R +GG++PRW  QK   AG++S          
Sbjct: 218 AKN--------------PQKAAAAGAKFREAGGRKPRWRGQKATEAGAKSRGGGGIKPQK 263

Query: 677 -AAVGQEAEARKKPRRRRAKSRGDG--GQNA 704
            AA G +    KKP RRR +S G+G  GQN+
Sbjct: 264 PAAAGAKIHGGKKP-RRRGQSSGNGVEGQNS 293



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 89/266 (33%), Positives = 121/266 (45%), Gaps = 36/266 (13%)

Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
           +RR+ +A AA+ R  G    RRR  K    R   +RS   +   +   +A  +   +  +
Sbjct: 81  QRRSMRAAAAQERSPG----RRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQVCGSSPQ 136

Query: 468 SRGD--KKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQ 525
           +RG   KK  RQKA+  G KSR         K     GQKA  AG K+   G K  G+++
Sbjct: 137 TRGGGGKKLQRQKATVMGAKSR---------KKPQHWGQKAATAGAKSPGGGGKKPGQEK 187

Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS--HGGGGNKQSRGGGGNKPRQWGQ--T 581
           P         AKSR GG K  +R+K  AAGA +         + R  GG KPR  GQ  T
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRKPRWRGQKAT 247

Query: 582 AAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQ-KAAGTGAKSRK---------- 630
            A AK+RGGG  +P  QK AA   K     GGKK  R+ +++G G + +           
Sbjct: 248 EAGAKSRGGGGIKP--QKPAAAGAKIH---GGKKPRRRGQSSGNGVEGQNSLAFLECDVE 302

Query: 631 -KPWRRGQKDAAAAEKAWATGATSRG 655
            K  R+  KD    E +  TG+   G
Sbjct: 303 GKVQRKTNKDNPRRESSRCTGSQVLG 328



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 74/214 (34%), Positives = 93/214 (43%), Gaps = 66/214 (30%)

Query: 628 SRKKPWRRGQKDAA-AAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
           +R  PWR   +DA  A  +   +   +RG GGK+ + QK    G++S            R
Sbjct: 111 TRSAPWRCLSQDAGRAGSQVCGSSPQTRGGGGKKLQRQKATVMGAKS------------R 158

Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAK 746
           KKP+          GQ AA                      GAKS G GG K    G  K
Sbjct: 159 KKPQH--------WGQKAATA--------------------GAKSPGGGGKK---PGQEK 187

Query: 747 -SRSGKKAAASKSHGGGGAKRRR--GGGAKSRSGEKAVTAGGQKAAAAGGKKP------- 796
            + +G+K  A+KS GGGG K RR     A +++ +KA  AG  K   AGG+KP       
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGA-KFREAGGRKPRWRGQKA 246

Query: 797 --PRVKSRGGRG---QKAAA------GGKKPLRR 819
                KSRGG G   QK AA      GGKKP RR
Sbjct: 247 TEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRR 280


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score =  103 bits (257), Expect = 6e-22
 Identities = 168/820 (20%), Positives = 292/820 (35%), Gaps = 99/820 (12%)

Query: 53   GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
            GSG      Q  +  G     +GQ G+ +G+ +   Q       +    +RG G  +++ 
Sbjct: 1290 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSG 1348

Query: 111  AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQG 170
             G    G      R R    +   S   +  +    ++ S   G+G+ +++     +S  
Sbjct: 1349 YGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 1408

Query: 171  GEKP---QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
             +     Q  + +G  S   +   R G  SRG+  + G    + S +G+   G R+    
Sbjct: 1409 WQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGE--RHGSSSGSSSSYGQHGSGSRQ---- 1462

Query: 228  PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
               + G  +   G G+ P   R  G+  +  G+S      G G               + 
Sbjct: 1463 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYSPYGSGS------------GWSS 1505

Query: 288  RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
             RG   +G   ++ G G R  +S  GQ+  +G+ G             + +G     G  
Sbjct: 1506 SRGPYESGSSHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG-- 1560

Query: 348  QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
            Q  A  G  S   Q   G      ++S  G +  G G   G    +R    R+ P +   
Sbjct: 1561 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 1614

Query: 408  RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
               + ++ ++   G G  +    G   + S           G    SG G+   R GQ +
Sbjct: 1615 GSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 1674

Query: 458  RQKAAEAGAESR---GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
            R +   + + S    G    G +++S  G +  G G     G++    G  +      + 
Sbjct: 1675 RGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSG 1734

Query: 515  AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGN 573
            +  + SRG  + R    +V G      G  S   Q    +G   S G  G+   +    +
Sbjct: 1735 SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 1794

Query: 574  KPRQWGQTAAAAKTRGGGDKQP---GWQKAAAGVTKSR----SGDGGKKAWRQKAAGTGA 626
            +       +++    G G  Q    G Q + +G + SR    SG G   ++ Q  +G+G 
Sbjct: 1795 QEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGW 1854

Query: 627  KSRKKPWRRGQKDAAA----AEKAW-ATGATSRGSG-GKQPRWQKPAAAGSESSAAAAVG 680
             S       G   ++        +W ++G T  GSG G    +++  +   +SS     G
Sbjct: 1855 SSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHG 1914

Query: 681  QEAEARKKPRRRRAKSR---GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGA 737
              + +     +  + SR   G G   +  G +P   RG        R G G+    S G 
Sbjct: 1915 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG--------RHGSGSGQSSSYGP 1966

Query: 738  KSRGSGGAKSRSGKKAAASKSHGGGGAKRRRG-----------GGAKSRSGEKAVTAG-- 784
               GSG + SR   ++ +  S G G  + R G            G  S  G+    +G  
Sbjct: 1967 YGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQS 2026

Query: 785  ---GQKAAAAG-----GKKPPRVKSRGGRGQKAAAGGKKP 816
               GQ  A++G     G+         G G++ +  G+ P
Sbjct: 2027 SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSP 2066



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 163/789 (20%), Positives = 279/789 (35%), Gaps = 80/789 (10%)

Query: 53   GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
            GSG      Q  +  G     +GQ G+ +G+ +   Q       +      G G  ++++
Sbjct: 1760 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSS 1818

Query: 111  AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-- 168
             G +  G      R R    +   S   +  +    ++ S   G+G+ +++     +S  
Sbjct: 1819 YGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 1878

Query: 169  -QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
             Q     Q  + +G  S   +   R G  SRG++   G    + S +G+   G R+    
Sbjct: 1879 WQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQH--GSSSGSSSSYGQHGSGSRQ---- 1932

Query: 228  PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
               + G  +   G G+ P   R  G+  +  G+S      G G               + 
Sbjct: 1933 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYGPYGSGS------------GWSS 1975

Query: 288  RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
             RG   +G   ++ G G R  +S  GQ+  +G+ G             +A+G     G  
Sbjct: 1976 SRGPYESGSGHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCG-- 2030

Query: 348  QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
            Q  A  G  S   Q   G      ++S  G +  G G   G    +R    R+ P +   
Sbjct: 2031 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 2084

Query: 408  RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
               + ++ ++   G G  +    G   + S           G    SG G+   R GQ +
Sbjct: 2085 GSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 2144

Query: 458  R--QKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
            R  +  + +G+ SR G    G +++S  G +  G G     G++    G  +      + 
Sbjct: 2145 RGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSG 2204

Query: 515  AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGN 573
            +  + SRG  + R    +V G      G  S   Q    +G   S G  G+   +    +
Sbjct: 2205 SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 2264

Query: 574  KPRQWGQTAAAAKTRGGGDKQP---GWQKAAAGVTKSR----SGDGGKKAWRQKAAGTGA 626
            +       +++    G G  Q    G Q + +G + SR    SG G   ++ Q  +G+G 
Sbjct: 2265 QEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGW 2324

Query: 627  KSRKKPWRRGQKDAAA----AEKAW-ATGATSRGSG-GKQPRWQKPAAAGSESSAAAAVG 680
             S       G   ++        +W ++G T  GSG G    +++  +   +SS     G
Sbjct: 2325 SSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHG 2384

Query: 681  QEAEARKKPRRRRAKSR---GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGA 737
              + +     +  + SR   G G   +  G +P            SRG  G+ S  S   
Sbjct: 2385 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSP----------SPSRGRHGSGSGQSSSY 2434

Query: 738  KSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
               GSG   S S     +   H  G   R    G  S  G+   ++G        G    
Sbjct: 2435 SPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSG 2494

Query: 798  RVKSRGGRG 806
            +  S G  G
Sbjct: 2495 QSSSCGQHG 2503



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 176/859 (20%), Positives = 307/859 (35%), Gaps = 90/859 (10%)

Query: 6    HRQCNQAAGRAGP-GAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKA 64
            H   ++ +   GP G   G + +R P E  +  ++        G +   SG      Q  
Sbjct: 548  HESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSS------GLGHQESRSGQSSGYGQHG 601

Query: 65   AAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRK 122
            ++ G  +   GQ G+ +G+ +   QH   +  +      G G  +++  G +   G G+ 
Sbjct: 602  SSSGHSST-HGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQG-SGSGQS 659

Query: 123  PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAA-GVKSQGGEKPQKAAAAG 181
            P R G+  +  G      +    +   S N   G+    ++  G KS  G+    +    
Sbjct: 660  PSR-GRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGS 718

Query: 182  AKSRSG---KKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK--HRRPKPAAGGAK 236
              S S    K   R G  SR ++   G      S +G+   G  +   H R    +G + 
Sbjct: 719  GSSHSSGYRKHGSRSGQSSRSEQH--GSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSP 776

Query: 237  SRRGGGKKPQKQRRRGQ--------------KAATGGKSRVGKSRGGGDKKLRRQGQNAA 282
            SR   G         GQ              ++ +G  S  G+   G  +   + G  + 
Sbjct: 777  SRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASG 836

Query: 283  LAGAKRRGAATAGEKPAA-KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
               ++ R  +T+G+  ++ +     G  S  GQ+           R G  + ++   G +
Sbjct: 837  HFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQR 896

Query: 342  RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
              G GQ  +         +    G+       S+        G   G  +    G G   
Sbjct: 897  GSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQ-HGSGSGHSS 955

Query: 402  PRWQNPRRRAQKAPAAK--PRGGGSKKPRRRGPKAAKSRG-GKSRSGGGKKPRRRGQKAR 458
               Q+  R  Q + + +     G S    + G  + +S G G+  SG G+ P     + R
Sbjct: 956  SYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP--SRGR 1013

Query: 459  QKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGA 518
              +    + S G  + G   +S+ G    G G  S  G    R GQ +   G+  +++G 
Sbjct: 1014 HGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQ-SSGYGQHGSSSGH 1072

Query: 519  KSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHG--GGGNKQSRGGGGNKP 575
             S              G      G  S   Q   ++G ++SHG  G G+ QS  G G + 
Sbjct: 1073 SS------------THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQS-SGYGRQG 1119

Query: 576  RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
               GQ+    +   G  + P + +  +G  +S S  G   +   +++G G          
Sbjct: 1120 SGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRS-SSSGQHGSGLGESSGFGHHESSS---- 1174

Query: 636  GQKDAAAAEKAWATGATSRGS-GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRA 694
            GQ  + +   + +  ++  G  G +  +  +    GS S +++  GQ     +       
Sbjct: 1175 GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR------- 1227

Query: 695  KSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAA 754
            +S G G Q +  G +P  R      LG S   G     GSG  +S   G  +SRSG  + 
Sbjct: 1228 QSSGHGRQGSGSGHSP-SRGRHGSGLGHSSSHG---QHGSGSGRSSSRGPYESRSGHSSV 1283

Query: 755  ASKSHGGGG-----AKRRRGGGAKSRSGEKAVTAG-----GQKAAAAG-----GKKPPRV 799
              +   G G     ++   G G     G+   T+G      Q+ ++ G     G +    
Sbjct: 1284 FGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGS 1343

Query: 800  KSRGGRGQKAAAGGKKPLR 818
                G G+  A  G+ P R
Sbjct: 1344 SQSSGYGRHGAGSGQSPSR 1362



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 169/762 (22%), Positives = 281/762 (36%), Gaps = 92/762 (12%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
            SG      Q  +A G+ +   GQ GA +G+ +  H Q   G+G +++ G G Q + +  +
Sbjct: 2010 SGHSSTHGQHGSASGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 2065

Query: 114  KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
               G RG   R+    G+  + +G         +S+++G    G G           S Q
Sbjct: 2066 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGPGLGESSGFGHHESSSGQ 2116

Query: 170  GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
                 Q  + +G  S  G+   R G  SRG+  + G    + SR+G+   G R+      
Sbjct: 2117 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSRYGQHGSGSRQ------ 2168

Query: 230  PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
             ++G  +   G G  P     RG+  +  G S      G G  +   +G   + +G    
Sbjct: 2169 -SSGHGRQGSGSGHSPS----RGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 2220

Query: 290  GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
             ++  G+  +     G G  S   Q+   G G      +GQ  + +  + T       Q+
Sbjct: 2221 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 2266

Query: 350  AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
             +  G  S   Q   G      ++S+ G +  G G     R     G G      Q+   
Sbjct: 2267 GSSTGQSSSHGQHGSGSS----QSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYGQHGSG 2321

Query: 410  RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
                + + +  G GS +    G   + S    G ++ G G           Q  + +G  
Sbjct: 2322 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG---HSSSYEQHGSRSGQS 2377

Query: 468  SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
            SRG++  G    S++     G G +   G      GQ    +G+  + + G    G  Q 
Sbjct: 2378 SRGER-HGSSSGSSSSYGQHGSGSRQSLG-----HGQHGSGSGQSPSPSRGRHGSGSGQS 2431

Query: 527  RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
                P  +G+    G S SR   ++   G+    G G+++SR G  +   Q G ++  + 
Sbjct: 2432 SSYSPYGSGS----GWSSSRGPYES---GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSS 2484

Query: 587  TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
            T G      G     G   A++G + S    G   +        G+ S + P   GQ+ +
Sbjct: 2485 THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 2543

Query: 641  AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
             + +   + G    GSG      Q  +  G  S          ++    +         G
Sbjct: 2544 GSRQSP-SYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2602

Query: 701  -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKS----RSGKKA 753
             GQ+ +     +  +R G         G  G+ SR S G   +GSG  +S    R G   
Sbjct: 2603 YGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 2662

Query: 754  AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
              S SHG  G G+ R    G  +SR G  +V   GQ  + +G
Sbjct: 2663 GHSSSHGQHGSGSGRSSSRGPYESRLGHSSVF--GQHESGSG 2702



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 169/762 (22%), Positives = 280/762 (36%), Gaps = 92/762 (12%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
            SG      Q  +  G+ +   GQ GA +G+ +  H Q   G+G +++ G G Q + +  +
Sbjct: 1070 SGHSSTHGQHGSTSGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 1125

Query: 114  KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
               G RG   R+    G+  + +G         +S+++G    G G           S Q
Sbjct: 1126 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGSGLGESSGFGHHESSSGQ 1176

Query: 170  GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
                 Q  + +G  S  G+   R G  SRG+  + G    + S +G+   G R+      
Sbjct: 1177 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSHYGQHGSGSRQ------ 1228

Query: 230  PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
             ++G  +   G G  P     RG+  +  G S      G G  +   +G   + +G    
Sbjct: 1229 -SSGHGRQGSGSGHSPS----RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 1280

Query: 290  GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
             ++  G+  +     G G  S   Q+   G G      +GQ  + +  + T       Q+
Sbjct: 1281 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 1326

Query: 350  AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
             +  G  S    R  G      ++S  G    G G     R     G G      Q+   
Sbjct: 1327 GSSTGQSSSYGHRGSGSS----QSSGYGRHGAGSGQSPS-RGRHGSGSGHSSSYGQHGSG 1381

Query: 410  RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
                + + +  G GS +    G   + S    G ++ G G           Q  + +G  
Sbjct: 1382 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGCTQHGSGSG---HSSSYEQHGSRSGQS 1437

Query: 468  SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
            SRG++  G    S++     G G +   G      GQ    +G+  + + G    G  Q 
Sbjct: 1438 SRGER-HGSSSGSSSSYGQHGSGSRQSLG-----HGQHGSGSGQSPSPSRGRHGSGSGQS 1491

Query: 527  RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
                P  +G+    G S SR   ++   G++   G G+++SR G  +   Q G ++  + 
Sbjct: 1492 SSYSPYGSGS----GWSSSRGPYES---GSSHSSGLGHRESRSGQSSGYGQHGSSSGHSS 1544

Query: 587  TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
            T G      G     G   A++G + S    G   +        G+ S + P   GQ+ +
Sbjct: 1545 THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 1603

Query: 641  AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
             + +   + G    GSG      Q  +  G  S          ++    +         G
Sbjct: 1604 GSRQSP-SYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 1662

Query: 701  -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKS----RSGKKA 753
             GQ+ +     +  +R G   R     G  G+ SR S G   +GSG  +S    R G   
Sbjct: 1663 YGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 1722

Query: 754  AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
              S SHG  G G+ R    G  +SRSG  +V   GQ  + +G
Sbjct: 1723 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVF--GQHESGSG 1762



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 171/762 (22%), Positives = 286/762 (37%), Gaps = 92/762 (12%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
            SG      Q  +  G+ +   GQ GA +G+ +  H Q   G+G +++ G G Q + +  +
Sbjct: 1540 SGHSSTHGQHGSTSGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 1595

Query: 114  KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
               G RG   R+    G+  + +G         +S+++G    G G           S Q
Sbjct: 1596 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGSGLGESSGFGHHESSSGQ 1646

Query: 170  GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
                 Q  + +G  S  G+   R G  SRG+  + G    + SR+G+   G R+      
Sbjct: 1647 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSRSSSRYGQHGSGSRQ------ 1698

Query: 230  PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
             ++G  +   G G+ P     RG+  +  G S      G G  +   +G   + +G    
Sbjct: 1699 -SSGHGRQGSGSGQSPS----RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 1750

Query: 290  GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
             ++  G+  +     G G  S   Q+   G G      +GQ  + +  + T       Q+
Sbjct: 1751 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 1796

Query: 350  AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
             +  G  S   Q   G      ++S+ G +  G G     R     G G      Q+   
Sbjct: 1797 GSSTGQSSSHGQHGSGSS----QSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYGQHGSG 1851

Query: 410  RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
                + + +  G GS +    G   + S    G ++ G G           Q  + +G  
Sbjct: 1852 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG---HSSSYEQHGSRSGQS 1907

Query: 468  SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
            SRG+     Q  S++G+ S  G   S S ++L   GQ    +G+  + + G    G  Q 
Sbjct: 1908 SRGE-----QHGSSSGSSSSYGQHGSGSRQSLGH-GQHGSGSGQSPSPSRGRHGSGSGQS 1961

Query: 527  RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
                P  +G+    G S SR   ++   G+    G G+++SR G  +   Q G ++  + 
Sbjct: 1962 SSYGPYGSGS----GWSSSRGPYES---GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSS 2014

Query: 587  TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
            T G      G     G   A++G + S    G   +        G+ S + P   GQ+ +
Sbjct: 2015 THGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 2073

Query: 641  AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
             + +   + G    GSG      Q     G  S          ++    +         G
Sbjct: 2074 GSRQSP-SYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2132

Query: 701  -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGG----AKSRSGKKA 753
             GQ+ +     +  +R G         G  G+ SR S G   +GSG     ++ R G  +
Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGS 2192

Query: 754  AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
              S SHG  G G+ R    G  +SRSG  +V   GQ  + +G
Sbjct: 2193 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVF--GQHESGSG 2232



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 132/621 (21%), Positives = 224/621 (36%), Gaps = 89/621 (14%)

Query: 278 GQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAA 337
           GQ+ + +G          +   + GRG  G  S  GQ+P +G+ G    +     T  + 
Sbjct: 167 GQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGS--GQSPNYGQHGSGSGQSSSNDTHGSG 224

Query: 338 AGTKRG-----------------GGGQQKAAVVGVK-SRKKQRRRGKKPRRQKASAAGAK 379
           +G   G                 G G   ++  G   SR  Q  RG++ R    S++   
Sbjct: 225 SGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYG 284

Query: 380 SRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKS-- 437
             G G ++ L   ++    R+ P        +  + +    G GS     RG   + S  
Sbjct: 285 QHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQ 344

Query: 438 --------RGGKSRSGGGKKPRRRGQKARQ-----------KAAEAGAESRGDKKQGRQK 478
                    G    SG  K     G  + Q            + + G+ SR     G+ +
Sbjct: 345 TSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHE 404

Query: 479 ASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS 538
             +A   S G G  S         GQ+   +G+ + ++G    G  +     P V+G+  
Sbjct: 405 --SASRHSSGRGQHSSGSGQSPGHGQRGSGSGQ-SPSSGQHGTGFGRSSSSGPYVSGS-G 460

Query: 539 RVGGSKSRQRQKAVAAGATSHGGG-------GNKQSRGGGGNKPRQWGQTAAAAKT---R 588
              G    +     ++G T HG G       G   SR G  ++  + G +A ++ +    
Sbjct: 461 YSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQH 520

Query: 589 GGGDKQP-GWQKAAAGVTKSRSGDGGK--KAWRQKAA------GTGAKSRKKPWRRGQKD 639
           G G +Q  G  +  +G  +S S   G+     RQ ++      G+G  S + P+  G   
Sbjct: 521 GSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGH 580

Query: 640 AAAAEKAWATGATSRG-------SGGKQPRWQKPAAAGSESSAA--AAVGQEAEARKKPR 690
           ++      +    S G       SG      Q  + +G  SS     A   ++ +  +  
Sbjct: 581 SSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHG 640

Query: 691 RRRAKSRGDGGQNAAVGINPWQRR-----GKKPRLGK-SRGGGGAKSRGSGGAKSRGSG- 743
              ++S   G Q +  G +P + R     G     G+   G G + S G  G+ S  S  
Sbjct: 641 SGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSG 700

Query: 744 -GAKSRSGKKAAASK-----SHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
            G KS SG+ +  S+     SH  G  K     G  SRS +   ++G    +++ G+   
Sbjct: 701 FGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSG---LSSSYGQHGS 757

Query: 798 RVKSRGGRGQKAAAGGKKPLR 818
                 G G++ +  G  P R
Sbjct: 758 GSHQSSGHGRQGSGSGHSPSR 778



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 169/844 (20%), Positives = 294/844 (34%), Gaps = 97/844 (11%)

Query: 53   GSGDKKLRRQ-KAAAGGKKARLRGQKGAVAGKE-ARQHWQKAAG--AGGAENRGGGEQKA 108
            GSG ++     +  +G   +   GQ G+ +    +R H++  +G  +G  ++  G  Q  
Sbjct: 300  GSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQ-- 357

Query: 109  AAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS 168
             ++G    G        +GQ  + +G      +A  S   GS +R + +     +A   S
Sbjct: 358  -SSGYSKHGSGSGHSSSQGQHGSTSG------QASSSGQHGSSSRQSSSYGQHESASRHS 410

Query: 169  QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRP 228
             G  + Q ++ +G     G++    G      +   G  R + S    +  G        
Sbjct: 411  SG--RGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHH 468

Query: 229  KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS----RVGKSRGGGDKKLRRQGQNAALA 284
            + ++  +      G         GQ  +  G+S    R G S G      +    +    
Sbjct: 469  ESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSL 528

Query: 285  GAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAG----- 339
            G  R G+ +      ++GR   G +      P     G+   R   ++    ++G     
Sbjct: 529  GHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQE 588

Query: 340  --TKRGGGGQQKAAVVGVKSRKKQR--RRGKKPR-RQKASAAGAKSRGGGDKKGLREAKR 394
              + +  G  Q  +  G  S   Q     G+     Q  + +G  S  G    G  ++ R
Sbjct: 589  SRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSR 648

Query: 395  RGDGRKKPRWQNPRRRAQ-----KAPAAKPRGGGSKKPRRRGPKAAKSR-----GGKSRS 444
             G  +     Q+P R         + +    G GS      GP  + S      G KS S
Sbjct: 649  YGQ-QGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGS 707

Query: 445  GGGKKPRRRGQKARQKAAEAGAESR-GDKKQGRQKASAAGTKSRGG--GLKSHSGKNLWR 501
            G      + G  +   +      SR G   +  Q  S++G  S  G  G  SH      R
Sbjct: 708  GQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGR 767

Query: 502  RGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKS--------RQRQKAVA 553
            +G  + +    +      S G      Q  +     S  G  +S         Q +    
Sbjct: 768  QG--SGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSG 825

Query: 554  AGATSHG-GGGNKQSRGGGGNKPRQ----------------WGQTAAAAKTRGGGDKQPG 596
             G + HG   G+  S+G  G+   Q                +GQ  +A+    G  +   
Sbjct: 826  QGYSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGS 885

Query: 597  WQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAA----AEKAWATGAT 652
                + G  +  SG G   ++ +  +G+G  S       G   ++     +    ++G T
Sbjct: 886  GSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYT 945

Query: 653  SRGSG-GKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR---GDGGQNAAVGI 708
              GSG G    +++  +   +SS +   G  + +     +  + SR   G G   +  G 
Sbjct: 946  QHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQ 1005

Query: 709  NPWQRRGK-------KPRLGKSRGGGG-AKSRG---SGGAKSRGSGGAKSRSGKKAAASK 757
            +P   RG+           G  R G G + SRG   SG   S G G  +SRSG+ +   +
Sbjct: 1006 SPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQ 1065

Query: 758  SHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG-----GKKPPRVKSRGGRGQKAAAG 812
             HG         G   S SG+   ++ GQ  A++G     G+         G G++ +  
Sbjct: 1066 -HGSSSGHSSTHGQHGSTSGQS--SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGS 1122

Query: 813  GKKP 816
            G+ P
Sbjct: 1123 GQSP 1126



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 121/602 (20%), Positives = 215/602 (35%), Gaps = 61/602 (10%)

Query: 53   GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
            GSG      Q  +  G     +GQ G+ +G+ +   Q       +      G G  ++++
Sbjct: 2230 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSS 2288

Query: 111  AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-- 168
             G +  G      R R    +   S   +  +    ++ S   G+G+ +++     +S  
Sbjct: 2289 YGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 2348

Query: 169  -QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
             Q     Q  + +G  S   +   R G  SRG+  + G    + S +G+   G R+    
Sbjct: 2349 WQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE--RHGSSSGSSSSYGQHGSGSRQ---- 2402

Query: 228  PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
               + G  +   G G+ P   R  G+  +  G+S      G G               + 
Sbjct: 2403 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYSPYGSGS------------GWSS 2445

Query: 288  RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
             RG   +G   ++ G G R  +S  GQ+  +G+ G             + +G     G  
Sbjct: 2446 SRGPYESGSGHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG-- 2500

Query: 348  QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
            Q  A  G  S   Q   G      ++S  G +  G G   G    +R    R+ P +   
Sbjct: 2501 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 2554

Query: 408  RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
               + ++ ++   G G  +    G   + S           G    SG G+   R GQ +
Sbjct: 2555 GSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 2614

Query: 458  R--QKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
            R  +  + +G+ S  G    G +++S  G +  G G     G++    G  +      + 
Sbjct: 2615 RGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSG 2674

Query: 515  AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHGGGGNKQSRGGG-G 572
            +  + SRG  + R    +V G      G  S   Q    +G   S G  G+   +     
Sbjct: 2675 SGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 2734

Query: 573  NKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKS------RSGDGGKKAWRQKAAGTGA 626
             +    GQ+++      G  +  G+ +  AG  +S       SG G   ++ Q  +G+G 
Sbjct: 2735 QEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSHGRHGSGSGQSSSYGQHGSGSGQ 2794

Query: 627  KS 628
             S
Sbjct: 2795 SS 2796


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 144/664 (21%), Positives = 250/664 (37%), Gaps = 99/664 (14%)

Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG-GRRKKHRRPKPAAGGAKSRRGG 241
           K +  KK + RG +S     ++ R++ +K +  ++    +++KHR P P     KS+R  
Sbjct: 186 KQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTP-----KSKR-- 238

Query: 242 GKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
            K   K+R+R +      KSR        D        +A+ +   R  + +A  K    
Sbjct: 239 -KSKDKKRKRSRSTTPAPKSRRAHRSTSAD--------SASSSDTSRSRSRSAAAKTHTT 289

Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQ 361
              GR P      +P  GR G+      +  T +    +      +Q ++    K + K+
Sbjct: 290 ALAGRSP------SPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK 343

Query: 362 RRRGKKPRRQKASAAGAKSRGGGDKKGLRE--AKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
            +   +P     S +  +S  G +        A+R G G  +P    P  +    P ++ 
Sbjct: 344 EKSATRP-----SPSPERSSTGPEPPAPTPLLAERHG-GSPQPLATTPLSQEPVNPPSE- 396

Query: 420 RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQG--RQ 477
               +   R R P  +  +  +S S     P  +  K  + A+ +    +     G  R+
Sbjct: 397 ----ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452

Query: 478 KASAAGTKSRGGGL----KSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAV 533
            +S+  +K+R  G     KSHS     R G+    +   ATA   +SR R   +R     
Sbjct: 453 ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGR----SRSPATAKRGRSRSRTPTKR----- 503

Query: 534 AGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDK 593
                  G S+SR  Q   +  A   G   + Q RG                  R    +
Sbjct: 504 -------GHSRSRSPQWRRSRSAQRWGRSRSPQRRG------------------RSRSPQ 538

Query: 594 QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKK-PWRRGQKDAAAAEKAWATGAT 652
           +PGW ++     + RS    +     ++  T  +SR + P RRG+  +    +     + 
Sbjct: 539 RPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPAR---RRSR 595

Query: 653 SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQ 712
           SR    ++ R + PA  G   S   A  +     + P RRR++SR    ++         
Sbjct: 596 SRTPTRRRSRSRTPARRGRSRSRTPA--RRRSRTRSPVRRRSRSRSPARRSGRSRSRTPA 653

Query: 713 RRGKK-----PRLGKSRGGGGAKSRG---------SGGAKSRGSGGAKSRSGKKAAASKS 758
           RRG+       R G+SR    A+  G          G ++SR     +SRS       +S
Sbjct: 654 RRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRS 713

Query: 759 HGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR---GQKAAAGGKK 815
           H     +R R G +  R  +   +    ++ ++   K  R+ SR  R     ++ A  + 
Sbjct: 714 HSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRL 773

Query: 816 PLRR 819
            LRR
Sbjct: 774 SLRR 777



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 129/601 (21%), Positives = 211/601 (35%), Gaps = 103/601 (17%)

Query: 70  KARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR----R 125
           K R R +    A K  R H   +A +  + +      ++AAA T +    GR P     R
Sbjct: 243 KKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR 302

Query: 126 RGQ----------------KAAATGSKKP--------RWRAQKSAAAGS---KNRGAGAQ 158
           RG+                 +  T +K+P        + + +KSA   S   +    G +
Sbjct: 303 RGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPE 362

Query: 159 KAAAAAGVKSQGGEKPQKAA--------------AAGAKSRS-GKKPRRRGAKSRGDEDK 203
             A    +  + G  PQ  A              A+  + RS  K P +    S  +   
Sbjct: 363 PPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSP 422

Query: 204 KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS-- 261
              Q    SR   +          PKPA      R        K R  G+       S  
Sbjct: 423 PSPQPTKVSRHASS------SPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHT 476

Query: 262 ---RVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG------PKSLG 312
              R+G+SR     K  R            R  +    +  +  R GR        +S  
Sbjct: 477 PSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRS 536

Query: 313 GQNPRWG-------RGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVG-----VKSRKK 360
            Q P W        RG  +  RRG+  +++ A    RG    +  A  G       +R++
Sbjct: 537 PQRPGWSRSRNTQRRGRSRSARRGRSHSRSPAT---RGRSRSRTPARRGRSRSRTPARRR 593

Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
            R R    RR ++     + R        R ++ R   R++ R ++P RR+ ++ +  P 
Sbjct: 594 SRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPA 653

Query: 421 GGG---SKKPRRRGPKAAKS---RGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
             G   S+ P RRG   +++   R G+SRS   + P RRG+   +      + SR   ++
Sbjct: 654 RRGRSRSRTPARRGRSRSRTPARRSGRSRS---RTPARRGRSRSRTPRRGRSRSRSLVRR 710

Query: 475 GRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAG-----EKATAAGAKSRGRKQPRRQ 529
           GR  +     + R G   S   KN  R  Q+   +      +K+  +  +SR    PR +
Sbjct: 711 GRSHSRTPQRRGRSG--SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSK 768

Query: 530 KPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGN---------KQSRGGGGNKPRQWGQ 580
             +    +  + GS    +QK+      S  G            ++SR      P+Q  +
Sbjct: 769 AKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSK 828

Query: 581 T 581
           T
Sbjct: 829 T 829



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/784 (19%), Positives = 275/784 (35%), Gaps = 108/784 (13%)

Query: 100 NRGGGEQKAAAAGTKS--LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA 157
           N    E+  AA G     + G    P+RR ++A     + P+  +    ++ S++     
Sbjct: 128 NEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ 187

Query: 158 QKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKT 217
           +K       K   G + + ++    + +S KK + R       + +K R    KS+  K+
Sbjct: 188 KKKKK----KKDRGRRSESSSPRRERKKSSKKKKHRSESE--SKKRKHRSPTPKSK-RKS 240

Query: 218 RGGRRKKHRRPKPAAGGAKSRRG------GGKKPQKQRRRGQKAATGGKSRVGKS----- 266
           +  +RK+ R   PA    ++ R             + R R   A T   +  G+S     
Sbjct: 241 KDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPAS 300

Query: 267 --RGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
             RG GD      G  +    +    A      P       +  KS    +P   R    
Sbjct: 301 GRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG 360

Query: 325 PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVK----------SRKKQRRRGKKPRRQKAS 374
           P         A     +R GG  Q  A   +           S  + R   K P +   S
Sbjct: 361 PEPPAPTPLLA-----ERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQS 415

Query: 375 AAGAKSRGGGDK-KGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
           ++   S       K  R A    +  K        R    +P +K R  G  K  +    
Sbjct: 416 SSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSH 475

Query: 434 AAKSRGGKSRSGGGKK--------PRRRG-------QKARQKAAEAGAESRGDKKQGRQK 478
               R G+SRS    K        P +RG       Q  R ++A+    SR  +++GR +
Sbjct: 476 TPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSR 535

Query: 479 AS-------AAGTKSRGGGLKSHSGKNLWR----RGQKAEAAGEKATAAGAKSRGRKQPR 527
           +        +  T+ RG    +  G++  R    RG+       +   + +++  R++ R
Sbjct: 536 SPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSR 595

Query: 528 RQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGG---------GNKPRQW 578
            + P    ++SR    + R R +  A   +       ++SR               P + 
Sbjct: 596 SRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARR 655

Query: 579 GQTAAAAKTRGGGDK------QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSR--- 629
           G++ +    R G  +      + G  ++     + RS     +  R ++     + R   
Sbjct: 656 GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHS 715

Query: 630 KKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKP 689
           + P RRG+  +++  K  +  +  R      P  +K   +   S + ++   +A++R   
Sbjct: 716 RTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSL 775

Query: 690 RRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG---AKSRGSGGAKSRGSGGAK 746
           RR  + S             P Q+    PR  +SR G     AKSR +   +SR S    
Sbjct: 776 RRSLSGSSPC----------PKQKSQTPPR--RSRSGSSQPKAKSR-TPPRRSRSSSSPP 822

Query: 747 SRSGKKAAASKSHGG--------GGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
            +   K  + +SH           G   R+G     ++ E++VT   Q+ +       P 
Sbjct: 823 PKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTP--QRRSCFESSPDPE 880

Query: 799 VKSR 802
           +KSR
Sbjct: 881 LKSR 884



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 126/607 (20%), Positives = 223/607 (36%), Gaps = 61/607 (10%)

Query: 116  LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQ 175
            LG R R      Q+     S  P+ R++  ++  SK       K       +S+ G  P+
Sbjct: 1533 LGQRSRSGS--SQELDVKPSASPQERSESDSSPDSK------AKTRTPLRQRSRSGSSPE 1584

Query: 176  ---KAAAAGAKSRSGKKPRRRG-------AKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
               K+  +  +SRSG  P  +        A+S  D   + +    ++   ++R G   K 
Sbjct: 1585 VDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKG 1644

Query: 226  RRPKPAAGGAKSRRGGGKKPQKQR--RRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
            R P P   G+ S     + P K R  RRG +++   K+   KSR    ++  R       
Sbjct: 1645 RGPSPE--GSSSTESSPEHPPKSRTARRGSRSSPEPKT---KSRTPPRRRSSRSSPELTR 1699

Query: 284  AGAKRRGAATAGEKPAAKGR-GGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
                 R + +A   P  + R   R  +S    +P      +  RRR   ++      ++R
Sbjct: 1700 KARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRR 1759

Query: 343  GGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKP 402
            G            K R  QR R +  RR+K      + R G  +     ++RR   R + 
Sbjct: 1760 GRSPSP-------KPRGLQRSRSRS-RREKTRTTRRRDRSGSSQS---TSRRRQRSRSRS 1808

Query: 403  RWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAA 462
            R    RR           G  S+ P R+      SR  + RS      R+R +     A 
Sbjct: 1809 RVTRRRRGGS--------GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP 1860

Query: 463  EAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRG 522
               + SR      R+  S     SR    +S +     RR +   +   + + + A    
Sbjct: 1861 WKRSRSRASPATHRRSRSRTPLISRRRS-RSRTSPVSRRRSRSRTSVTRRRSRSRASPVS 1919

Query: 523  RKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGG--------NKQSRGGGGNK 574
            R++ R + P V   +SR     +R+R ++     T                +SR     +
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITR 1979

Query: 575  PRQWGQTAAAAKTRGGGDKQPGWQKAA----AGVTKSRSGDGGKKAWRQKAAGTGAKSRK 630
             R   +T+   + R      P  ++ +    + VT+ RS      A R+++    +++  
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSR---SRTPL 2036

Query: 631  KPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPR 690
             P +R +  +  A +  +   T R + GK+   + P A    S++ ++  +   A     
Sbjct: 2037 LPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPAT 2096

Query: 691  RRRAKSR 697
            R  + SR
Sbjct: 2097 RNHSGSR 2103



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 98/445 (22%), Positives = 177/445 (39%), Gaps = 62/445 (13%)

Query: 58  KLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLG 117
           + +R K+ +     R+   +     K  R   +     G + +R    +++ +A      
Sbjct: 466 RAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSA---QRW 522

Query: 118 GRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
           GR R P+RRG+  +    ++P W   ++     ++R A             + G    ++
Sbjct: 523 GRSRSPQRRGRSRSP---QRPGWSRSRNTQRRGRSRSA-------------RRGRSHSRS 566

Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKS 237
            A   +SRS    RR  ++SR    ++ R R    R  ++R   R+   R +  A     
Sbjct: 567 PATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPA----R 622

Query: 238 RRGGGKKPQKQRRRGQK-AATGGKSRVGKSRGGGDKKLR---RQGQNAALAGAKRRGAAT 293
           RR   + P ++R R +  A   G+SR       G  + R   R+G++ +   A+R G + 
Sbjct: 623 RRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSR 682

Query: 294 AGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR-RRGQKATKAAAAGTKRGGGGQQKAAV 352
           +   PA +GR          + PR GR   +   RRG+  ++      + G   ++K   
Sbjct: 683 S-RTPARRGRS-------RSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKN-- 732

Query: 353 VGVKSRKKQR--RRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQN--PR 408
              KSR  QR  R    P  +K+  +  +SR     +   +AK R   R+     +  P+
Sbjct: 733 ---KSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRS--KAKSRLSLRRSLSGSSPCPK 787

Query: 409 RRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAES 468
           +++Q  P     G    K + R P        +SRS     P+   QK++  + ++ + S
Sbjct: 788 QKSQTPPRRSRSGSSQPKAKSRTPPR------RSRSSSSPPPK---QKSKTPSRQSHSSS 838

Query: 469 RGDKKQGRQKASAAGTKSRGGGLKS 493
               K        +GT  R G + S
Sbjct: 839 SPHPK------VKSGTPPRQGSITS 857



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 131/657 (19%), Positives = 237/657 (36%), Gaps = 54/657 (8%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
            S  +  +R+  +   ++ R   +  A  G   R   +  A  G + +R    +++ +   
Sbjct: 543  SRSRNTQRRGRSRSARRGRSHSRSPATRG---RSRSRTPARRGRSRSRTPARRRSRSRTP 599

Query: 114  KSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK 173
                 R R P RRG+  + T +++ R R +      S++R    +   + +   ++ G  
Sbjct: 600  TRRRSRSRTPARRGRSRSRTPARR-RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRS 658

Query: 174  PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG----GRRKKHRRPK 229
              +  A   +SRS    RR G        ++GR R    R G++R      R + H R  
Sbjct: 659  RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTP 718

Query: 230  PAAG--GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG-----DKKLRRQGQNAA 282
               G  G+ S R    +  ++R R   +    KSR+   R         K   R     +
Sbjct: 719  QRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRS 778

Query: 283  LAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
            L+G+       +   P     G   PK+     PR  R    P  + +  T +  + +  
Sbjct: 779  LSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSS 838

Query: 343  GGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKP 402
                +       VKS    R+      +    +   + R   +     E K R   R   
Sbjct: 839  SPHPK-------VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSC 891

Query: 403  RWQNPRR-RAQKAPAAKPRGGGSKKPRRR---GPKAAKSRGGKSRSGGGKKPRRRGQKAR 458
               +P R ++   P   P    S +P+ +    P+     G  S S      R   +++R
Sbjct: 892  SGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSR 951

Query: 459  QKAAEAGAESRGDKKQGRQKASAAGTKSR--GGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
              +  +  ESR   +     +S+  TK +      +SHSG        KA+      T  
Sbjct: 952  SVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ------TPP 1005

Query: 517  GAKSRGRKQPRRQKPAVAGAKSRVGGSKSR-QRQKAVAAGATSHGGGGNKQSRGGGGNKP 575
            G    G K P  Q+ +         GS S     K+      S+ G  + Q +G     P
Sbjct: 1006 GPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSP 1065

Query: 576  RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
                 T ++ + R    + P  Q      +KS++   G ++ R  +  T   SR  P R+
Sbjct: 1066 DHRSDT-SSPEVRQSHSESPSLQ------SKSQTSPKGGRS-RSSSPVTELASR-SPIRQ 1116

Query: 636  GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQE----AEARKK 688
             + + +A+           G   +Q R+Q  +++     + + +GQ     AE+++K
Sbjct: 1117 DRGEFSASP------MLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK 1167



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 131/716 (18%), Positives = 270/716 (37%), Gaps = 90/716 (12%)

Query: 105  EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSK----------NRG 154
            E+ ++A+  +   G  R P RR +  ++ G +       + + +GS           +RG
Sbjct: 1417 ERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRG 1476

Query: 155  AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQRE---AK 211
                 ++       Q      ++ ++   +     P+R  + S    D+K   R     +
Sbjct: 1477 RSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQR 1536

Query: 212  SRFGKTRGGRRKKHRRP--KPAAGGAKSRRGGGKKPQKQR-RRGQKAATGGKSRVG--KS 266
            SR G ++    K    P  +  +  +   +   + P +QR R G       KSR+   +S
Sbjct: 1537 SRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRS 1596

Query: 267  RGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR 326
            R G   +++ + +    A  + +  + +  +P A        +S  G + +    G+ P 
Sbjct: 1597 RSGSSPEVKDKPR----AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSK----GRGPS 1648

Query: 327  RRGQKATKAA---AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKK-----------PRRQK 372
              G  +T+++      ++    G + +     KSR   RRR  +            RR +
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708

Query: 373  ASAAGAKSRGGGDKKGLR-------------EAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
            ++++  ++R     +  R              + RR      PR +   RR  ++P+ KP
Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRG-RSPSPKP 1767

Query: 420  RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA----AEAGAESRGDKKQG 475
            RG    + R R  K   +R  + RSG  +   RR Q++R ++       G      +   
Sbjct: 1768 RGLQRSRSRSRREKTRTTR-RRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826

Query: 476  RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
            RQ++S   ++ R G  ++        R + + A  +++ +  + +  R+  R + P ++ 
Sbjct: 1827 RQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRS-RSRTPLISR 1885

Query: 536  AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP 595
             +SR   S   +R+       T        +SR    ++ R   +T    + R       
Sbjct: 1886 RRSRSRTSPVSRRRSRSRTSVTRR----RSRSRASPVSRRRSRSRTPPVTRRR------- 1934

Query: 596  GWQKAAAGVTKSRSGDGGKKAWRQKA-AGTGAKSRKKPWRRGQKDAAAAEKAWATGATSR 654
               ++    T+ RS        R+++ + T   +R++   R         ++  +  T R
Sbjct: 1935 --SRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR 1992

Query: 655  GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPR-RRRAKSRGD------GGQNAAVG 707
             S   + R        S S  +    + + +R  P  RRR++SR            + + 
Sbjct: 1993 RS---RSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLA 2049

Query: 708  INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAA--ASKSHGG 761
            I    RR  + R  ++  G  + +R     + R + G+ S   + A   A+++H G
Sbjct: 2050 I----RRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSG 2101



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 108/548 (19%), Positives = 203/548 (37%), Gaps = 63/548 (11%)

Query: 6    HRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAA 65
            H   ++ A R    +P     +RTP    +  ++P L+  A          +  RR ++A
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKA----------RLSRRSRSA 1710

Query: 66   AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG---TKSLGGRGRK 122
            +   + R R           R+    ++     ++R    +++A++    T S  GR   
Sbjct: 1711 SSSPETRSR------TPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764

Query: 123  PRRRGQKAAATGSKKPRWRA----QKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK-PQKA 177
            P+ RG + + + S++ + R      +S ++ S +R     ++ +    + +GG     ++
Sbjct: 1765 PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824

Query: 178  AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKS 237
             A    SR+  + RR  +++     K+ R R + + +           +R +  A  A  
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPW-----------KRSRSRASPATH 1873

Query: 238  RRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEK 297
            RR   + P   RRR +   +    R  +SR       RR+ ++ A   ++RR   +    
Sbjct: 1874 RRSRSRTPLISRRRSRSRTSPVSRRRSRSR---TSVTRRRSRSRASPVSRRR---SRSRT 1927

Query: 298  PAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
            P    R  R       +  R  R     RRR +  T      T+R    + ++    +  
Sbjct: 1928 PPVTRRRSRSRTPTTRRRSR-SRTPPVTRRRSRSRTPPV---TRR----RSRSRTSPITR 1979

Query: 358  RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
            R+ + R     RR+  S     +R     +     +RR   R  P     RRR++     
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPA---IRRRSRSRTPL 2036

Query: 418  KPRGGGSKKPRRRGPKA--AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQG 475
             PR    K+ R R P A   +SR    R+  GK+   R   A ++ + +G+ S       
Sbjct: 2037 LPR----KRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSS-----DR 2087

Query: 476  RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
             + A+   T++  G        N  R    +  +         +S G  +P         
Sbjct: 2088 SRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMS 2147

Query: 536  AKSRVGGS 543
               + GGS
Sbjct: 2148 VLQQAGGS 2155



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 91/469 (19%), Positives = 168/469 (35%), Gaps = 28/469 (5%)

Query: 366  KKPRRQKASAAGAKSRGGG--------DKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
            + P R+++S+A +     G         + G     R G G       +      K    
Sbjct: 1412 RTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPR 1471

Query: 418  KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQ 477
             P  G S+      PKA      + RS     P    +    +   +G+ES  D+K   +
Sbjct: 1472 TPSRGRSECDSSPEPKALPQTP-RPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR 1530

Query: 478  KASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAK 537
              +  G +SR G  +    K      +++E+     + A  ++  R++ R        +K
Sbjct: 1531 --TPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSK 1588

Query: 538  SRVGGSKSRQ------RQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGG 591
            SR+   +SR       + K  AA     G   + + +        +  ++ +++K RG  
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS 1648

Query: 592  DK-QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
             +     + +     KSR+   G ++  +       KSR  P RR  + +    +     
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKT----KSRTPPRRRSSRSSPELTRKARLS 1704

Query: 651  ATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP 710
              SR S    P  +         S + +  + AE  +  RRRR+ S       +  G +P
Sbjct: 1705 RRSR-SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSP 1763

Query: 711  WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770
                  KPR G  R    ++   +   + R   G+   + ++   S+S      +RR G 
Sbjct: 1764 ----SPKPR-GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS 1818

Query: 771  GAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
            G  SRS  +  ++        G  + P    +  R + + A  K+   R
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSR 1867



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 99/496 (19%), Positives = 183/496 (36%), Gaps = 55/496 (11%)

Query: 366 KKPRRQKASAAGAKSRGGGD----KKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
           KK  R +A+   + S   G     ++  REAK+      KP        + ++P  K + 
Sbjct: 130 KKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKK 189

Query: 422 GGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR---GDKKQGRQK 478
              KK R R  +++  R  + +S   KK R   +  ++K      +S+    DKK+ R +
Sbjct: 190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSR 249

Query: 479 ASAAGTKS----RGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR------ 528
           ++    KS    R     S S  +  R   ++ AA    TA   +S      RR      
Sbjct: 250 STTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAP 309

Query: 529 ---------QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG 579
                    Q+P+     ++   S    + K     + +      ++S  G    P    
Sbjct: 310 FSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG----PEPPA 365

Query: 580 QTAAAAKTRGGG---------DKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK 630
            T   A+  GG           ++P    + A  T+ RS     +   Q ++   +    
Sbjct: 366 PTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425

Query: 631 KPWRRGQKDAAAAEK---AWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARK 687
           +P +  +  +++ E    A A G+    S     + +    A  + S +    +     +
Sbjct: 426 QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485

Query: 688 KP---RRRRAKSRGDGGQNAAVGINP-WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
            P   +R R++SR    +  +   +P W+R     R G+SR     + RG   +  R  G
Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR---SPQRRGRSRSPQR-PG 541

Query: 744 GAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRG 803
            ++SR+ ++   S+S    G    R    + RS  +     G+  +    + P R +SR 
Sbjct: 542 WSRSRNTQRRGRSRS-ARRGRSHSRSPATRGRSRSRTPARRGRSRS----RTPARRRSRS 596

Query: 804 GRGQKAAAGGKKPLRR 819
               +  +  + P RR
Sbjct: 597 RTPTRRRSRSRTPARR 612



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 91/493 (18%), Positives = 175/493 (35%), Gaps = 34/493 (6%)

Query: 356 KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAP 415
           ++R+ ++   + P+        + SR    K+  ++ K++ D  ++    +PRR  +K+ 
Sbjct: 156 RAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ--KKKKKKKDRGRRSESSSPRRERKKSS 213

Query: 416 AAKPRGGGS--KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKK 473
             K     S  KK + R P     R  K +     +      K+R+      A+S     
Sbjct: 214 KKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSD 273

Query: 474 QGRQKASAAGTKSRGGGLKSHS-GKNLWRRGQKAEAAGEKATAA----GAKSRGRKQP-- 526
             R ++ +A  K+    L   S      RRG+      E  T +     +     KQP  
Sbjct: 274 TSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSS 333

Query: 527 --------RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW 578
                   +++K A   + S    S   +        A  HGG     +      +P   
Sbjct: 334 PYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNP 393

Query: 579 GQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQK 638
              A+  + R          ++++  +   S    K +    ++    K    P    + 
Sbjct: 394 PSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREI 453

Query: 639 DAAAAEKAWATGATSRGS------GGKQPRWQKPAAAGSESSAAAAVGQEAEAR-KKPRR 691
            ++   K  + G   R          +  R + PA A    S +    +   +R + P+ 
Sbjct: 454 SSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQW 513

Query: 692 RRAKSRGDGGQNAAVGINPWQRRGKKPRLGKS-----RGGGGAKSRGSGGAKSRGSGGAK 746
           RR++S    G++ +       R  ++P   +S     RG   +  RG   ++S  + G +
Sbjct: 514 RRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRG-R 572

Query: 747 SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
           SRS   A   +S     A+RR      +R   ++ T    +   +  + P R +SR    
Sbjct: 573 SRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPA--RRGRSRSRTPARRRSRTRSP 630

Query: 807 QKAAAGGKKPLRR 819
            +  +  + P RR
Sbjct: 631 VRRRSRSRSPARR 643



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 84/457 (18%), Positives = 166/457 (36%), Gaps = 47/457 (10%)

Query: 356  KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR---RG--------DGRKKPRW 404
            ++  ++ R G  P  +  S   ++    G   G+++  R   RG        + +  P+ 
Sbjct: 1433 RTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQT 1492

Query: 405  QNPRRRAQKAPAA--------KPRGGGS----KKPRRRGPKAAKSRGGKSRSGGGK---K 449
              PR R+  +P          + R G      +K   R P   +SR G S+    K    
Sbjct: 1493 PRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSAS 1552

Query: 450  PRRRGQKARQKAAEAGAESRGDKKQGRQKASA--AGTKSRGGGLKSHSGKNLWRRGQKAE 507
            P+ R +     + ++ A++R   +Q  +  S+    +KSR    +S SG +      + +
Sbjct: 1553 PQERSES--DSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS-----PEVK 1605

Query: 508  AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS 567
                 A  A + S    +P+   P     +SR G S   +      + +T        +S
Sbjct: 1606 DKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKS 1665

Query: 568  RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTG-- 625
            R       R+  +++   KT+     +    +++  +T+       + + R ++A +   
Sbjct: 1666 RTA-----RRGSRSSPEPKTKSRTPPRRRSSRSSPELTRK-----ARLSRRSRSASSSPE 1715

Query: 626  AKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEA 685
             +SR  P  R     ++ E A  + ++ R      PR +  +  G   S      Q + +
Sbjct: 1716 TRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRS 1775

Query: 686  RKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA 745
            R +  + R   R D   ++       QR   + R+ + R GG      S   +      +
Sbjct: 1776 RSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSS 1835

Query: 746  KSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVT 782
            + R G+      S     ++       +SRS     T
Sbjct: 1836 RRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPAT 1872



 Score = 37.0 bits (84), Expect = 0.074
 Identities = 29/138 (21%), Positives = 59/138 (42%), Gaps = 10/138 (7%)

Query: 123  PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA-AG 181
            P +R ++++++ S      +  S+++ S +  + +  +++++   S     P K    A 
Sbjct: 2600 PAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQAL 2659

Query: 182  AKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKP--------AAG 233
             K  S KKP     +SR         R+++S    +   RR+   +P P          G
Sbjct: 2660 PKPASPKKPPPGERRSRSPRKPIDSLRDSRS-LSYSPVERRRPSPQPSPRDQQSSSSERG 2718

Query: 234  GAKSRRGGGKKPQKQRRR 251
              + +RG  + P  +RRR
Sbjct: 2719 SRRGQRGDSRSPSHKRRR 2736



 Score = 33.5 bits (75), Expect = 0.82
 Identities = 102/510 (20%), Positives = 169/510 (33%), Gaps = 63/510 (12%)

Query: 286  AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
            A  R  A A     A  R    P ++   +PR           G +   A AA +  G G
Sbjct: 2257 ADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTA-PAVNLAGARTPAALAALSLTGSG 2315

Query: 346  GQQKAAVVGVKSRKKQRRRGKK---PRRQKASA----AGAKSRGGGDKKGLREAKRRGDG 398
                AA     SR  Q         PR   A+A    AG+++        L  A      
Sbjct: 2316 TPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSA------ 2369

Query: 399  RKKPRWQNPRRRAQKAP-AAKPRGGGSKKP------RRRGPKAAKSRGGKSRSGGGKKPR 451
            R  P        + + P +A  R  G   P      R R P +A S+   +         
Sbjct: 2370 RMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSS 2429

Query: 452  RRGQKARQ----------KAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKS-------- 493
            R GQ   Q          ++    A S   +    Q    AG++S   G  +        
Sbjct: 2430 RMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGD 2489

Query: 494  HSGK-NLWRRGQKAEAAGEKATAAGAK---SRGRKQPRRQKPAVAGAKSRVGGSKSRQRQ 549
            H+G  ++   G      GE   + GA+   +    QP +++      +S    S S    
Sbjct: 2490 HNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKER------RSSSSSSSSSSSS 2543

Query: 550  KAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRS 609
             + ++ ++S    G+  S   G + P Q      A K        P   K A    +   
Sbjct: 2544 SSSSSSSSSSSSSGSSSSDSEGSSLPVQ---PEVALKRVPSPTPAP---KEAVREGRPPE 2597

Query: 610  GDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAA 669
                K+  R  ++ + + S           ++++  + ++ ++S  S    P   KP   
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657

Query: 670  GSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGA 729
                 A+       E R +  R+   S  D   + ++  +P +RR   P+         +
Sbjct: 2658 ALPKPASPKKPPPGERRSRSPRKPIDSLRD---SRSLSYSPVERRRPSPQPSPRDQQSSS 2714

Query: 730  KSRGSGGAKSRGS-GGAKSRSGKKAAASKS 758
              RGS     RG  G ++S S K+   + S
Sbjct: 2715 SERGS----RRGQRGDSRSPSHKRRRETPS 2740



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 28/151 (18%), Positives = 55/151 (36%), Gaps = 27/151 (17%)

Query: 122  KPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKP------- 174
            K +RR   ++++ S      +  S+++ S +  + +  +++++   S    KP       
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661

Query: 175  ----QKAAAAGAKSRSGKKP----------------RRRGAKSRGDEDKKGRQREAKSRF 214
                +K      +SRS +KP                RRR +      D++    E  SR 
Sbjct: 2662 PASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRR 2721

Query: 215  GKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
            G+    R   H+R +        R    + P
Sbjct: 2722 GQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 102/563 (18%), Positives = 170/563 (30%), Gaps = 82/563 (14%)

Query: 16   AGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRG 75
            A   A +  A ARTP    A + A + + AAA    L S                 R   
Sbjct: 2234 AASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLAS----------------PRTAV 2277

Query: 76   QKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGS 135
               AV   + R     A    GA       +  AA    SL G G  P         T +
Sbjct: 2278 APSAVNLADPRTPTAPAVNLAGA-------RTPAALAALSLTGSGTPP---------TAA 2321

Query: 136  KKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGA 195
              P       A A +   G  +  A A   +    G +   A A  + + +   P   GA
Sbjct: 2322 NYPSSSRTPQAPASANLVGPRSAHATAPVNI---AGSRTAAALAPASLTSARMAPALSGA 2378

Query: 196  KSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKA 255
                               G+T      + R   P +  ++SR    + P    R GQ  
Sbjct: 2379 NLTSPRVPLSAYERVS---GRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAP 2435

Query: 256  ATG------GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK 309
            +         + R        D+      Q   +AG++   +       ++ G    G  
Sbjct: 2436 SQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAG-DHNGML 2494

Query: 310  SLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR 369
            S+          G+ P            A T    G QQ +A+  ++  K++R       
Sbjct: 2495 SVPAPGVPHSDVGEPP------------AST----GAQQPSALAALQPAKERRSSSSSSS 2538

Query: 370  RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR 429
               +S++ + S       G   +   G          P    ++ P+  P          
Sbjct: 2539 SSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP----VQPEVALKRVPSPTP---------- 2584

Query: 430  RGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGG 489
              PK A   G        K+ RR    +   ++ + + S          +S++ + S   
Sbjct: 2585 -APKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643

Query: 490  GLKSHSGKNLWRRGQKA--EAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQ 547
               S S  +  + G +A  + A  K    G   R  + PR+   ++  ++S       R+
Sbjct: 2644 --SSSSSPSPAKPGPQALPKPASPKKPPPG--ERRSRSPRKPIDSLRDSRSLSYSPVERR 2699

Query: 548  RQKAVAAGATSHGGGGNKQSRGG 570
            R     +          + SR G
Sbjct: 2700 RPSPQPSPRDQQSSSSERGSRRG 2722


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 146/754 (19%), Positives = 269/754 (35%), Gaps = 87/754 (11%)

Query: 64   AAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKP 123
            +A   +++  R  + +  G+ A  H Q  +  G  E  G G Q++A +   S  GRG   
Sbjct: 349  SADSSRQSGTRHAETSSRGQTASSHEQARSSPG--ERHGSGHQQSADSSRHSATGRG--- 403

Query: 124  RRRGQKAAATGSKKPRWRAQKSAAAG-SKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGA 182
              +   A +    +    +Q S + G S+N    +      AG++ Q  ++  +  +   
Sbjct: 404  --QASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGER 461

Query: 183  KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG 242
              RSG    +     + D         A  R G + GGR+  H          +  R   
Sbjct: 462  SGRSGSSLYQVSTHEQPD--------SAHGRTGTSTGGRQGSHH---------EQARDSS 504

Query: 243  KKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG 302
            +    Q  +       G SR G+     ++ + R G     +G+      + G   A+  
Sbjct: 505  RHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGH----SGSHHSHTTSQGRSDASH- 559

Query: 303  RGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQR 362
                            G+ G +   R  +  + +  GT+  G    +A+     SR  Q 
Sbjct: 560  ----------------GQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQV 603

Query: 363  RRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG 422
             +G+       S+    SR  G     +++  +G      RW     R     A +    
Sbjct: 604  GQGQ-------SSGPRTSRNQGSSVS-QDSDSQGHSEDSERWSGSASRNHHGSAQEQSRD 655

Query: 423  GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
            GS+ PR       + R G   S      R+ G +  Q ++   A S  +     Q  S+A
Sbjct: 656  GSRHPRSH----HEDRAGHGHSADSS--RKSGTRHTQNSSSGQAASSHE-----QARSSA 704

Query: 483  GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
            G +        H  ++   + Q A+++    T  G  S   +    +  + + A    G 
Sbjct: 705  GER--------HGSRH---QLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGH 753

Query: 543  SKSRQRQKAVAAGATSHGGGGNKQS-RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
            S+    Q     G   H    +++S R   G + R+ G       T    +   GW   +
Sbjct: 754  SEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPS 813

Query: 602  AGVTKSRSGDGGKKAWRQKAAGTGAKS-RKKPW--RRGQKDAAAAEKAWATGATSRGSGG 658
             GV +    +  +   R  A+  G  + R  P   RRG++ +   +    +G +      
Sbjct: 814  TGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSH 873

Query: 659  KQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKP 718
               + +  A+ G   S +A     +   +   + R  SR  G ++     +    R  + 
Sbjct: 874  TTSQGRSDASRGQSGSRSA-----SRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQA 928

Query: 719  RLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKSHGGGGAKRRRGGGAKSRSG 777
              G+S G   ++ +GS  ++   S G    S +   +AS++H G   ++ R G    RS 
Sbjct: 929  GQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSH 988

Query: 778  EKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
             +     G  A ++     P  ++  G GQ A++
Sbjct: 989  HEDRAGHGHSADSSRQSGTPHAETSSG-GQAASS 1021



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 163/852 (19%), Positives = 304/852 (35%), Gaps = 138/852 (16%)

Query: 60   RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAA--------A 111
            R  + ++GG+ A    Q  + AG+    H Q++A +      G G+  +A         +
Sbjct: 2953 RHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYS 3012

Query: 112  GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA------QKAAAAAG 165
            G+++    G       Q  +A G      ++ + +A G     +G       Q +     
Sbjct: 3013 GSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQS 3072

Query: 166  VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
              S G   P      G++    +   R  A   G +  +G         G +RGGR+  H
Sbjct: 3073 ESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHP-------GSSRGGRQGYH 3125

Query: 226  RRPKPAAGG--------------AKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR---G 268
                  + G              + + RG        R    +  +G  SR   SR    
Sbjct: 3126 HEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEA 3185

Query: 269  GGDKKLRR-----QGQNAALAGAKRRGAATAGE-------KPAAKGRGGRGPKSLGGQNP 316
                 + R     QGQ+     ++R+G++ + +       + + +  G       G    
Sbjct: 3186 STHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQE 3245

Query: 317  RWGRGGKKPRRR-------GQKATKAAAAGTKRG---GGGQQKAAVVGVKSRKKQR---- 362
            +   G + PR         G  A ++  +GT+      GGQ  ++    +S   +R    
Sbjct: 3246 QSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSR 3305

Query: 363  --------RRGKKPRRQKASAA------GAKSRGGGDKKGLREAKRR----GDGRKKPRW 404
                    R    PR Q +SA       G+      D +G  E        G G+  P  
Sbjct: 3306 HQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQ 3365

Query: 405  QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEA 464
            Q+ +  A+     +    GS   +    + ++S  G++R+  G++     ++AR  +  +
Sbjct: 3366 QSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHS 3425

Query: 465  GAESR--------GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
             ++          G  ++GRQ +    +  R G   SH       +G+   + G+    +
Sbjct: 3426 ASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTT-SQGRSDASRGQ----S 3480

Query: 517  GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
            G++S  R Q R  + +  G++     S S   + +  A ++ H   G  QS G   ++  
Sbjct: 3481 GSRSASR-QTRNDEQSGDGSRH----SWSHHHEASTQADSSRHSQSGQGQSAGPRTSR-N 3534

Query: 577  QWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRG 636
            Q    +  + ++G  +    W  +A     SR+  G   A  Q   G+   +     R G
Sbjct: 3535 QGSSVSQDSDSQGHSEDSERWSGSA-----SRNHRGS--AQEQSRDGSRHPTSHHEDRAG 3587

Query: 637  QKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKS 696
               +A + +   T      SGG+        AA S   A ++ G+   +  +     ++ 
Sbjct: 3588 HGHSAESSRQSGTHHAENSSGGQ--------AASSHEQARSSAGERHGSHHQQSADSSRH 3639

Query: 697  RGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAAS 756
             G G   A+  +          R    RG  G+++  S G        + S  G+     
Sbjct: 3640 SGIGHGQASSAV----------RDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQ 3689

Query: 757  KSHGGGGAKRRRGGGAKSRSG---------EKAVTAGGQKAAAAGGKKPPR-VKSRGGRG 806
            +SH    + R R  G   RSG         E++ +A G+   + GG++  R  ++R    
Sbjct: 3690 QSH--QESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSR 3747

Query: 807  QKAAAGGKKPLR 818
              A+  G+  +R
Sbjct: 3748 HSASQEGQDTIR 3759



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 158/826 (19%), Positives = 281/826 (34%), Gaps = 88/826 (10%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
            SG          + G+     GQ G+ +   +RQ  +      G+ + G    +AA+   
Sbjct: 1188 SGHSGSHHSHTTSQGRSDASHGQSGSRSA--SRQTRKDKQSGDGSRHSGSRHHEAASWAD 1245

Query: 114  KSLGGR-------GRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGA-GAQKAAAAAG 165
             S   +       G +  R    + +  S   R        +GS +R   G+ +  +  G
Sbjct: 1246 SSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDG 1305

Query: 166  VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK- 224
             +  G  +  +A+  G  + S ++      +S           +A+S  G+  G R ++ 
Sbjct: 1306 SRHPGFHQEDRASH-GHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQS 1364

Query: 225  ----------HRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDK-K 273
                      HR+   A   +  R   G +        + + T   S  G++       K
Sbjct: 1365 ADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHK 1424

Query: 274  LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
               +GQ+   +G  R           ++   G+   S GG   R G   ++ R   + + 
Sbjct: 1425 ESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGG---RQGSRHEQARNSSRHSA 1481

Query: 334  KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
                  T RG  G  +    G    +   R G        +    +S     + G R A 
Sbjct: 1482 SQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSAS 1541

Query: 394  RRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRR 453
            R+            R   Q    ++  G    +P  R   +  S+ G+  S G K  RR+
Sbjct: 1542 RQ-----------TRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQ 1590

Query: 454  GQKARQKAAEAGAESRGDKKQ---GRQKASAAGTKSRGGGLKSHSGK-NLWRRGQKAEAA 509
            G    Q     G     +++     R    +A  +SR G     S + +    G  AE++
Sbjct: 1591 GSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESS 1650

Query: 510  GEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG-----------SKSRQRQKAVAAGATS 558
             +  T     S G +    Q+ A +    R G            S + +RQ +   G + 
Sbjct: 1651 RQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSG 1710

Query: 559  HGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGG----- 613
            + G    Q+    G+      Q+ +A      G  Q   Q++  G +  RSG  G     
Sbjct: 1711 NRGSSGSQASDSEGHSEESDTQSVSAHGQ--AGPHQQSHQESTRGQSGERSGRSGSFLYQ 1768

Query: 614  -------KKAWRQKAAGTGAK--SRKKPWRRGQKDAAAAE-KAWATGATSRGSGGKQPRW 663
                   + A  +    TG +  SR +  R   + +A+ E +    G      GG+Q   
Sbjct: 1769 VSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSH 1828

Query: 664  QKPAAAGSESSAA------------AAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
             + +   S  S +             + GQ        + R  K  GDG +++    +  
Sbjct: 1829 YEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEA 1888

Query: 712  QRRGKKPR---LGKSRGGGGAKSRGSGGAKSRGS---GGAKSRSGKKAAASKSHGGGGAK 765
              R    R   +G+ +  G   SR  G + S+ S   G ++       +AS++H G   +
Sbjct: 1889 SSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWE 1948

Query: 766  RRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
            + R G     S  +   AG   +A +  +   R      RGQ A++
Sbjct: 1949 QSRDGSRHPGSHHED-RAGHGHSADSSRQSGTRHTESSSRGQAASS 1993



 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 148/786 (18%), Positives = 283/786 (36%), Gaps = 75/786 (9%)

Query: 66   AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRR 125
            AG  +    GQ  +   K +R+     +    +E      ++ + + +++  G  R+  R
Sbjct: 1568 AGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSR 1627

Query: 126  RGQKAAATGSKKPRWR---AQKSAAAGSKNR--GAGAQKAAAAAGVKSQGGEKP----QK 176
             G +   +  +        A+ S  +G+++    +G Q A++    +S  GE+     Q+
Sbjct: 1628 HGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQ 1687

Query: 177  AAAAGAKSRSGKKPR--------RRGAKSRGDEDKKGRQREAKSRFGKTRGG---RRKKH 225
            +A +   S +G++           RG+      D +G   E+ ++     G     ++ H
Sbjct: 1688 SADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSH 1747

Query: 226  RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
            +       G +S R G    Q       ++A G   R G S GG  +    Q ++++   
Sbjct: 1748 QESTRGQSGERSGRSGSFLYQVSTHEQSESAHG---RTGPSTGGRQRSRHEQARDSSRHS 1804

Query: 286  AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
            A + G  T    P +  RGGR            G  G          T    +   RG  
Sbjct: 1805 ASQEGQDTIRGHPGSS-RGGRQGSHYEQSVDSSGHSGS----HHSHTTSQERSDVSRGQS 1859

Query: 346  GQQKAAVVGVKSRKKQRRRGKK---PRRQKASAAGAKSR----GGGDKKGLREAKRRGDG 398
            G +  +V      +KQ   G +    R  +AS+    SR    G G   G R ++ +G  
Sbjct: 1860 GSR--SVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSS 1917

Query: 399  RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKAR 458
              +         +Q       R  GS      G    +SR G    G   + R     + 
Sbjct: 1918 VSQDS------DSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSA 1971

Query: 459  QKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGA 518
              + ++G  +R  +   R +A+++  ++R    + H   +   + Q A+++       G 
Sbjct: 1972 DSSRQSG--TRHTESSSRGQAASSHEQARSSAGERHGSHH---QLQSADSSRHSGIGHGQ 2026

Query: 519  KSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHGGGGNKQSRGGGGNKPRQ 577
             S   +    +  + + A    G S+    Q   A G A  H     + +RG  G    +
Sbjct: 2027 ASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGR 2086

Query: 578  WGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK------K 631
             G       T    +   G    + G  +    D  + + R  A+  G  + +      +
Sbjct: 2087 SGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSR 2146

Query: 632  PWRRGQKDAAAAEKAWATGA-----TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
              R+G     + +++  +G+     TS+G      R Q  + + S  +       +    
Sbjct: 2147 GGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDAS-RGQSGSRSASRKTYDKEQSGDGSRH 2205

Query: 687  KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAK 746
                   A S  D  +++ VG             G+S G   ++ RGS  ++   S G  
Sbjct: 2206 SGSHHHEASSWADSSRHSLVG------------QGQSSGPRTSRPRGSSVSQDSDSEGHS 2253

Query: 747  SRSGKKA-AASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
              S +++ +AS++H G   ++ R G    RS  +     G  A ++        ++  G 
Sbjct: 2254 EDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSG- 2312

Query: 806  GQKAAA 811
            GQ A++
Sbjct: 2313 GQAASS 2318



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 180/934 (19%), Positives = 335/934 (35%), Gaps = 164/934 (17%)

Query: 6    HRQCNQAAGRAGPGAPL---GAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR-- 60
            H+Q +Q + R   G      G+ L +      +ES+    +  + GV+  GS  ++ R  
Sbjct: 771  HQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSH-GWTGPSTGVR-QGSHHEQARDN 828

Query: 61   -RQKAAAGGKKARLRGQKGAVA-GKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG 118
             R  A+  G+   +RG  G+   G++   H Q    +G      G       +       
Sbjct: 829  SRHSASQDGQDT-IRGHPGSSRRGRQGSHHEQSVDRSG----HSGSHHSHTTS------- 876

Query: 119  RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAA 178
            +GR    RGQ  + + S+  R   ++ +  GS++ G+   +A++ A +        + + 
Sbjct: 877  QGRSDASRGQSGSRSASRTTR--NEEQSRDGSRHSGSRHHEASSHADIS-------RHSQ 927

Query: 179  AAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFG------------KTRGGRRKKHR 226
            A   +S   +  RR+G+    D D +G   +++   G            ++R G R    
Sbjct: 928  AGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRS 987

Query: 227  RPKPAAG---GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
              +  AG    A S R  G    +    GQ A++  ++R       G +  ++   ++  
Sbjct: 988  HHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRH-QQSADSSRH 1046

Query: 284  AGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW------GRGGKKPRRRGQKATKAAA 337
            +G  RR A++A       G  G       G +         G G   P ++  + +    
Sbjct: 1047 SGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDW 1106

Query: 338  AGTKRGGGG---------QQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG 388
            +G + G  G         +Q  +  G       RR+G    + + S+  + S+ G D   
Sbjct: 1107 SGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIR 1166

Query: 389  LREAKRRGDGRKKPRWQN----------------------------PRRRAQKAPAAKPR 420
                 RRG  +     Q+                             R  +++    K  
Sbjct: 1167 AHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQS 1226

Query: 421  GGGSKKPRRRGPKAAK-------SRGGKSRSGGGKKPRRRGQKARQKAAE---------- 463
            G GS+    R  +AA        S+ G+ +S G +  R +G    Q +            
Sbjct: 1227 GDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERL 1286

Query: 464  AGAESRG----DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAK 519
            +G+ SR      ++Q R  +   G          HS  +  + G     +     A  + 
Sbjct: 1287 SGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSH 1346

Query: 520  SRGRKQP------RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGN 573
             + R  P      R Q+ A +   S +G      RQ + A   + H G    Q     G+
Sbjct: 1347 EQARSSPGERHGSRHQQSADSSRHSGIG-----HRQASSAVRDSGHRGSSGSQVTNSEGH 1401

Query: 574  KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSG------------DGGKKAWRQKA 621
                  Q+ +A      G  Q   +++A G +   SG            +  +    Q A
Sbjct: 1402 SEDSDTQSVSAHGQ--AGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTA 1459

Query: 622  AGTGAK--SRKKPWRRGQKDAAAAE-KAWATGATSRGSGGKQPRWQKPAAAGSESS---- 674
              TG +  SR +  R   + +A+ + +    G      GG+Q  + + +   S  S    
Sbjct: 1460 PSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHH 1519

Query: 675  --------AAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPR-----LG 721
                    + A+ GQ        + R  +  GDG +++    +    R    R      G
Sbjct: 1520 SHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQG 1579

Query: 722  KSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKA-AASKSHGGGGAKRRRGGGAKSRSGEKA 780
            +S G   ++ +GS  ++ R S G    S +++ +AS++H G   ++ R G    RS ++ 
Sbjct: 1580 ESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQED 1639

Query: 781  VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
              + G  A ++        +  G R  + ++GG+
Sbjct: 1640 RASHGHSAESS--------RQSGTRHAETSSGGQ 1665



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 155/777 (19%), Positives = 267/777 (34%), Gaps = 68/777 (8%)

Query: 61   RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
            R+++  G +      +  A  G  A    Q  +G    E+   G+  ++    +S  G  
Sbjct: 1299 REQSRDGSRHPGFHQEDRASHGHSADSSRQ--SGTHHTESSSHGQAVSSHEQARSSPGE- 1355

Query: 121  RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
            R   R  Q A ++       R   SA   S +RG+   +        S+G  +     + 
Sbjct: 1356 RHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVT-----NSEGHSEDSDTQSV 1410

Query: 181  GAKSRSGKKPRRRGAKSRGDE-DKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRR 239
             A  ++G   +     +RG   +  GR R    +           H +  P+ GG +  R
Sbjct: 1411 SAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSE-STHGQTAPSTGGRQGSR 1469

Query: 240  GGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQG-QNAALAGAKRRGAATAGEKP 298
                +   +    Q      +   G SRGG       Q    +  +G         G   
Sbjct: 1470 HEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSD 1529

Query: 299  AAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQK----ATKAAAAGTKRGGGGQQKAAVVG 354
            A+ G+ G  P+S   Q     + G   R  G +    +T+A ++   + G G+      G
Sbjct: 1530 ASHGQSG--PRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGES----AG 1583

Query: 355  VKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG----LREAKRRGDGRKKPRWQNPRRR 410
             K+ ++Q     + R  +  +  ++ R     +      RE  R G   + PR     R 
Sbjct: 1584 SKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGS--RNPRSHQEDRA 1641

Query: 411  AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG 470
            +    A   R  G++         A S   ++RS  G++   R     Q++A++  +S  
Sbjct: 1642 SHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSR----HQQSADSSTDSGT 1697

Query: 471  DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
             ++Q       +G +   G   S S       G   E+  +  +A G     ++  +   
Sbjct: 1698 GRRQDSSVVGDSGNRGSSGSQASDS------EGHSEESDTQSVSAHGQAGPHQQSHQEST 1751

Query: 531  PAVAGAKSRVGGS----KSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
               +G +S   GS     S   Q   A G T    GG ++SR        +   +     
Sbjct: 1752 RGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQD 1811

Query: 587  TRGG--GDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAE 644
            T  G  G  + G Q +    +   SG  G       +      SR +   R        E
Sbjct: 1812 TIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNE 1871

Query: 645  KAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK--SRGDGGQ 702
            K   +G  SR SG +       A++ ++SS  + VGQ   +  +  R +    S+    Q
Sbjct: 1872 K--QSGDGSRHSGSR----HHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQ 1925

Query: 703  NAAVGINPWQRRGKKPRLG----KSRGGG--------GAKSRGSGGAKSRGSGGAKSRSG 750
              +     W     +  LG    +SR G              G     SR SG   + S 
Sbjct: 1926 GHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESS 1985

Query: 751  KKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG-GKKPPRVKSRGGRG 806
             +  A+ SH     + R   G +  S  +  +A   + +  G G+    V+  G RG
Sbjct: 1986 SRGQAASSH----EQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRG 2038



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 146/776 (18%), Positives = 282/776 (36%), Gaps = 107/776 (13%)

Query: 61   RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
            ++++  G +  R   +  A  G  A    Q  +G   AEN  GG+  AA++  ++    G
Sbjct: 2272 QEQSRDGSRHPRSHHEDRAGHGHSAESSRQ--SGTHHAENSSGGQ--AASSHEQARSSAG 2327

Query: 121  RKPRRRGQKAAATGSKKPRWRAQKSAAA-GSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA 179
             +     Q++A +         Q S+A   S +RG+   +A+ + G       +   A  
Sbjct: 2328 ERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHG 2387

Query: 180  AGAKSRSGKKPRRRGAKSRGDEDKKG----------RQREAKSRFGKTRGGRRKKHRRPK 229
                 +   +   RG +S G   + G          +   A  R G + GGR+  H    
Sbjct: 2388 QAGPHQQSHQESTRG-RSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHH--- 2443

Query: 230  PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
                  K  R   +    Q  +       G S  G+     ++ + R G +    G+   
Sbjct: 2444 ------KQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHS----GSHHS 2493

Query: 290  GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR--RRGQKATKAAAAGTKRGGGGQ 347
               + G   A+ G  G    S   +N      G +    R  + +++A ++G  + G GQ
Sbjct: 2494 HTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQ 2553

Query: 348  QKAAVV----GVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR 403
             +        G    +    +G     ++ S + +++  G  ++ LR      DG + PR
Sbjct: 2554 SEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLR------DGSRHPR 2607

Query: 404  WQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAE 463
                 R      A   R  G++  +      A S   ++RS  G++     Q++   +  
Sbjct: 2608 SHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRH 2667

Query: 464  AGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR 523
            +G         G  +AS+A    R  G + +SG         +E +  ++ +A  ++ G 
Sbjct: 2668 SGI--------GHGQASSA---VRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQA-GS 2715

Query: 524  KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAA 583
             Q   Q+ A   +    G S S   Q +    + S  G     +RG  G++  Q   ++ 
Sbjct: 2716 HQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSR 2775

Query: 584  AAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK----AAGTGAKSRKKPWRRGQKD 639
             + ++ G D   G            S  GG++ +  +    ++G           +G+ D
Sbjct: 2776 HSASQDGQDTIRG---------HPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSD 2826

Query: 640  AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
            A+        G +   S  +  R ++ +  GS  S +             R   A +  D
Sbjct: 2827 ASR-------GQSGSRSASRTTRNEEQSGDGSRHSGS-------------RHHEASTHAD 2866

Query: 700  GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKS 758
              +++            +   G+S G   ++ +GS  ++   S G    S +   +AS++
Sbjct: 2867 ISRHS------------QAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRN 2914

Query: 759  HGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
            H G   ++ R G    RS ++     G  A ++        +  G R  + ++GG+
Sbjct: 2915 HHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSS--------RQSGTRHTQTSSGGQ 2962



 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 163/835 (19%), Positives = 286/835 (34%), Gaps = 130/835 (15%)

Query: 60   RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAA--------A 111
            R  + ++GG+ A    Q  + AG+    H Q++A +      G G+  +A         +
Sbjct: 2629 RHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYS 2688

Query: 112  GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAG------AQKAAAAAG 165
            G+++    G       Q  +A G      ++ + +A G     +G       Q +     
Sbjct: 2689 GSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQS 2748

Query: 166  VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
              S G   P      G++    +   R  A   G +  +G         G +RGGR+  H
Sbjct: 2749 ESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHP-------GSSRGGRQGYH 2801

Query: 226  RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
                  + G       G        +G+  A+ G+S        G +   R  +N   +G
Sbjct: 2802 HEHSVDSSG-----HSGSHHSHTTSQGRSDASRGQS--------GSRSASRTTRNEEQSG 2848

Query: 286  AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
               R + +   + +      R  +++ GQ+     G ++ RR+G   ++     +   G 
Sbjct: 2849 DGSRHSGSRHHEASTHADISRHSQAVQGQS----EGSRRSRRQGSSVSQ----DSDSEGH 2900

Query: 346  GQQKAAVVGVKSR------KKQRRRGKK-PRRQKASAAG-AKSRGGGDKKGLREAKRRGD 397
             +      G  SR      ++Q R G + PR  +   AG   S     + G R  +    
Sbjct: 2901 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2960

Query: 398  GRKKPRWQNPRRRA---------QKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGK 448
            G+     +  R  A         Q A +++  G G      +   A +  G +  S G +
Sbjct: 2961 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIG----HGQASSAVRDSGHRGYS-GSQ 3015

Query: 449  KPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEA 508
                 G           A  +    Q   + SA G   R G    HSG  L++     ++
Sbjct: 3016 ASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARG---RSGETSGHSGSFLYQVSTHEQS 3072

Query: 509  AGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSR 568
                    G  +RGR+  R ++     A+     S S+  Q  +     S  GG      
Sbjct: 3073 ESSHGW-TGPSTRGRQGSRHEQ-----AQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHH 3126

Query: 569  GGGGNKPRQWGQTAAAAKTRGGGDKQPG--WQKAAAGVTKS--RSGDGGK-KAWRQKAAG 623
                +     G   +   ++G  D   G    ++A+  T++  +SGD  +    R   A 
Sbjct: 3127 EHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEAS 3186

Query: 624  TGAK-SRKKPWRRGQKDAAAAEKAWATGAT----SRGSGGKQPRWQKPAAAGSESSA--- 675
            T A  SR     +GQ + +   +   +  +    S G      RW   A+     S    
Sbjct: 3187 THADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQ 3246

Query: 676  --------------AAAVGQEAEARKKPRRRRAKSRGDGGQNAA----VGINPWQRRGKK 717
                           A  G  A+  ++   R A++   GGQ A+       +P +R G +
Sbjct: 3247 SRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAET-SSGGQAASSHEQARSSPGERHGSR 3305

Query: 718  -------------PRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGG- 763
                         PR   S     ++  GS G+++  S G    S  ++ +   HG  G 
Sbjct: 3306 HQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVS--GHGQAGP 3363

Query: 764  -------AKRRRGGGAKSRSGE--KAVTAGGQKAAAAGGKKPPRVKSRGGRGQKA 809
                   + R R GG   RSG     V+   Q  +A G  +    + +G   ++A
Sbjct: 3364 HQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQA 3418



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 146/799 (18%), Positives = 263/799 (32%), Gaps = 97/799 (12%)

Query: 54   SGDKKLRRQKAAAGGKKARLRGQKGA-VAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG 112
            SG          + G+    RGQ G+  A +  R   Q    +  + +R       A   
Sbjct: 3133 SGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADIS 3192

Query: 113  TKSLGGRG-----RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVK 167
              S   +G     R+ RR+G   +     +      +  +  +     G+ +  +  G +
Sbjct: 3193 RHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSR 3252

Query: 168  SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
                    +A    +  RS +   R    S G +     + +A+S  G+  G R ++   
Sbjct: 3253 HPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHE-QARSSPGERHGSRHQQSAD 3311

Query: 228  -------PKPAAGGA--KSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQG 278
                   P+  A  A   SR  G    Q     G    +  +S  G  + G  ++  ++ 
Sbjct: 3312 SSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQES 3371

Query: 279  QNAALAGAKRRGAA---TAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKA 335
                  G   R  +          ++   GR   S G    R G   ++ R   + +   
Sbjct: 3372 ARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGR---RQGSHHEQARDSSRHSASQ 3428

Query: 336  AAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRR 395
                T RG  G  +    G    +   R G        + +  +S     + G R A R+
Sbjct: 3429 EGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQ 3488

Query: 396  -------GDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGK 448
                   GDG +   W +    + +A +++                  S+ G+ +S G +
Sbjct: 3489 TRNDEQSGDGSRHS-WSHHHEASTQADSSR-----------------HSQSGQGQSAGPR 3530

Query: 449  KPRRRGQKARQKAAEAGAESRGDKKQG---RQKASAAGTKSRGGGLKSHSG-KNLWRRGQ 504
              R +G    Q +   G     ++  G   R    +A  +SR G     S  ++    G 
Sbjct: 3531 TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGH 3590

Query: 505  KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG----SKSRQRQKAVAAGATS-- 558
             AE++ +  T     S G +     + A + A  R G     S    R   +  G  S  
Sbjct: 3591 SAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSA 3650

Query: 559  -----HGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGG 613
                 H G    Q+    G+      Q+ +A      G  Q   Q++  G +  RSG  G
Sbjct: 3651 VRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQ--AGPHQQSHQESTRGRSAGRSGRSG 3708

Query: 614  KKAWR-----QKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA-----TSRGS-----GG 658
               ++     Q  +  G        R+G +   A + +  + +     T RG      GG
Sbjct: 3709 SFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGG 3768

Query: 659  KQPRWQKPAAAGSESSAA------------AAVGQEAEARKKPRRRRAKSRGDGGQNAAV 706
            +Q  + + +   S  S +            A+ GQ          R  +  GDG +++  
Sbjct: 3769 RQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828

Query: 707  GINPWQRRGKKPR---LGKSRGGGGAKSRGSGGAKSRGSGG---AKSRSGKKAAASKSHG 760
              +    +    R    G+    G  +SR  G + S+ S      +    +  +AS++H 
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHH 3888

Query: 761  GGGAKRRRGGGAKSRSGEK 779
            G   ++ R G     S  +
Sbjct: 3889 GSSREQSRDGSRHPGSSHR 3907



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 120/659 (18%), Positives = 237/659 (35%), Gaps = 92/659 (13%)

Query: 186 SGKKPRRRG-----AKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
           SG K R+         ++ +E+K+ R+R +       R G + + + P+   G     + 
Sbjct: 97  SGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGG-----KR 151

Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
                +K+ R+G  + T  +   GK+     KK + + +N  L   ++R +    EK   
Sbjct: 152 HESSSEKKERKGY-SPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDN 210

Query: 301 KGRGGRGPKSLGGQNPRWGRGG----------------------KKPRRRGQKATKAAAA 338
           +  G    ++ G    +W + G                       K   R + +   +++
Sbjct: 211 E-EGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSS 269

Query: 339 GTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA----GAKSRGGGDKKGLREA-K 393
              R     +  + V ++  + ++RRG +  + + S        +  G   +     A +
Sbjct: 270 QVNR--SRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWE 327

Query: 394 RRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRR 453
           +  DG + PR  +  R +    A   R  G+    R    +++ +   S       P  R
Sbjct: 328 QSRDGSRHPRSHDEDRASHGHSADSSRQSGT----RHAETSSRGQTASSHEQARSSPGER 383

Query: 454 GQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA 513
                Q++A++   S   + Q     S  G +   G   S S        +      +  
Sbjct: 384 HGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDS--------EGHSENSDTQ 435

Query: 514 TAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGN 573
           + +G    G +Q   Q+     +  R G S S   Q +      S  G     + G  G+
Sbjct: 436 SVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGS 495

Query: 574 KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPW 633
              Q   ++  + ++ G D   G   ++ G    R G   +++  +  +G          
Sbjct: 496 HHEQARDSSRHSASQEGQDTIRGHPGSSRG---GRQGSHHEQSVNR--SGHSGSHHSHTT 550

Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR 693
            +G+ DA       + G +   S  +Q R ++ +  G+  S +             R   
Sbjct: 551 SQGRSDA-------SHGQSGSRSASRQTRNEEQSGDGTRHSGS-------------RHHE 590

Query: 694 AKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-K 752
           A S+ D  +++ VG             G+S G   ++++GS  ++   S G    S +  
Sbjct: 591 ASSQADSSRHSQVG------------QGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWS 638

Query: 753 AAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
            +AS++H G   ++ R G    RS  +   AG   +A +  K   R       GQ A++
Sbjct: 639 GSASRNHHGSAQEQSRDGSRHPRSHHED-RAGHGHSADSSRKSGTRHTQNSSSGQAASS 696



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 99/527 (18%), Positives = 185/527 (35%), Gaps = 78/527 (14%)

Query: 43   SAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG--AGGAEN 100
            S A+ G     S  ++ R  + +  G +        A    ++ +H Q   G  AG   +
Sbjct: 3473 SDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTS 3532

Query: 101  RGGGEQKAAAAGTKS--------LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAG--- 149
            R  G   +  + ++          G   R  R   Q+ +  GS+ P    +  A  G   
Sbjct: 3533 RNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSA 3592

Query: 150  --SKNRG-------AGAQKAAAAAGVKSQGGEKP----QKAAAA--------GAKSRSGK 188
              S+  G       +G Q A++    +S  GE+     Q++A +        G  S + +
Sbjct: 3593 ESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVR 3652

Query: 189  KPRRRGAKSRGDEDKKGRQREAKSRFGKTRGG---RRKKHRRPKPAAGGAKSRRGGGKKP 245
                RG+      D +G   ++ ++     G     ++ H+         +S R G    
Sbjct: 3653 DSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLY 3712

Query: 246  QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
            Q       ++A G   R G S GG       Q ++++   A + G  T    P ++ RGG
Sbjct: 3713 QVSTHEQSESAHG---RAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSR-RGG 3768

Query: 306  R--------------------GPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
            R                       S G  +   G+ G +   R  +  + +  G++  G 
Sbjct: 3769 RQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828

Query: 346  GQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLRE-AKRRGDGRKKPRW 404
               +A+     SR  Q  +G+    +++   G+      D +   E ++RR +   +   
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHH 3888

Query: 405  QNPRRRAQKAPAAKPRGGGSKKP---RRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA 461
             + R +++          GS+ P    R      +S   +S S   K+       ++  A
Sbjct: 3889 GSSREQSR---------DGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSA 3939

Query: 462  AEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEA 508
              +G +SRG        +S+   +S G   +      +WR G    A
Sbjct: 3940 YHSGIQSRGSP----HSSSSYHYQSEGTERQKGQSGLVWRHGSYGSA 3982



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 118/691 (17%), Positives = 242/691 (35%), Gaps = 112/691 (16%)

Query: 60   RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAA--------AA 111
            R  + ++GG+ A    Q  +  G+      Q++A +        G+  +A        ++
Sbjct: 3277 RHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSS 3336

Query: 112  GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAA---AGSKNRGAGA---QKAAAAAG 165
            G+++    G       Q  +  G   P  ++ + +A   +G ++  +G+   Q +     
Sbjct: 3337 GSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQS 3396

Query: 166  VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKT-------- 217
              + G  +       G+     +   R  A   G +  +G      SR G+         
Sbjct: 3397 ESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHP--GSSRRGRQGSHYEQSV 3454

Query: 218  -RGGRRKKHRRPKPAAGGAKSRRG--GGKKPQKQRRRGQKAATGGK-------------- 260
             R G    H     + G + + RG  G +   +Q R  +++  G +              
Sbjct: 3455 DRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQAD 3514

Query: 261  ----SRVGKSRGGGDKKLRRQGQNAALAGAKR---------RGAATAGEKPAAKGR---G 304
                S+ G+ +  G +  R QG + +     +          G+A+   + +A+ +   G
Sbjct: 3515 SSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDG 3574

Query: 305  GRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRR 364
             R P S        G   +  R+ G    + ++ G +     +Q  +  G +     ++ 
Sbjct: 3575 SRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGG-QAASSHEQARSSAGERHGSHHQQS 3633

Query: 365  GKKPRRQ-----KASAA-------GAKSRGGGDKKGLREAKRR----GDGRKKPRWQNPR 408
                R       +AS+A       G+      D +G  E          G+  P  Q+ +
Sbjct: 3634 ADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQ 3693

Query: 409  RRAQKAPAAKPRGGGS--------KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQK 460
               +   A +    GS        ++      +A  S GG+     G +  +    +R  
Sbjct: 3694 ESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQ----GSRHEQARDSSRHS 3749

Query: 461  AAEAGAES----RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
            A++ G ++     G ++ GRQ +    +  R G   SH      +    A      + +A
Sbjct: 3750 ASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSA 3809

Query: 517  GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
              ++R  +Q        +G  SR  G  SR  + +  A ++ H   G  +S G   ++ R
Sbjct: 3810 SRETRNEEQ--------SGDGSRHSG--SRHHEASTQADSSRHSQSGQGESAGSRRSR-R 3858

Query: 577  QWGQTAAAAKTRGGGDKQPGWQKAAA----GVTKSRSGDGGK---KAWRQKAAGTGA--- 626
            Q    +  + +    +      ++A+    G ++ +S DG +    + R  A+   +   
Sbjct: 3859 QGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSSPV 3918

Query: 627  -KSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
                      G   + + + A+ +G  SRGS
Sbjct: 3919 QSDSSTAKEHGHFSSLSQDSAYHSGIQSRGS 3949


>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
          Length = 653

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 117/570 (20%), Positives = 214/570 (37%), Gaps = 97/570 (17%)

Query: 220 GRRKKH---RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
           G R KH       P     K ++GG ++ +K+RR   + + G  S + K +    K +++
Sbjct: 153 GYRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKK----KSVKK 208

Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
             ++ + +G++R+    +      +    +  K    ++P     G++  R    ++ + 
Sbjct: 209 HRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESP-----GRRSHRHSSGSSHSP 263

Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
           +  +               +   K R  G+K   Q++S + + S  GG   G  + +  G
Sbjct: 264 SLSSHYSDSRSPS------RLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQ-RNGG 316

Query: 397 DGRK----------------KPRWQNPRRRAQKAPAAK-PRGGGSKKPRRRGPKAAKSRG 439
            G++                KP   +PR R + A AA  P   G + P  R   +++ RG
Sbjct: 317 SGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRG 376

Query: 440 GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNL 499
           G++  G G++ RRR ++ R +++ +    RG ++        +          S SG   
Sbjct: 377 GRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGR 436

Query: 500 WRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH 559
              G   E   E+      K R +++P R +PA         G +               
Sbjct: 437 GAPGPGPEPGSERGHGGHGK-RAKERPPRARPASTSPSPGAHGRR--------------- 480

Query: 560 GGGGNKQSRGGGGNKPRQWGQTAAAAKTRG-GGDKQPGWQKAAAGVTK--SRSGDGGKKA 616
           GG   K S    G  PR W  + + +K+R    +K+P     +    K  SR  DG  +A
Sbjct: 481 GGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRA 540

Query: 617 WRQKAAGTGAKSRKK---PWRRGQKDAAA-AEKAWATGATSRGSGGKQPRWQKPAAAGSE 672
              +A  T A+ R +   P R+ ++D+ +  E    T A  R     +P         S 
Sbjct: 541 RHSEAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRP---------SP 591

Query: 673 SSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSR 732
           SS+++ +  +   R   R                           P  G S G   ++S 
Sbjct: 592 SSSSSCLSSDYSTRSHSR--------------------------SPSPGHSHGSYSSRSH 625

Query: 733 GSGGAKSRGSGGAKSRSGKKAAASKSHGGG 762
           G+   +SR    +++ S    + S S  GG
Sbjct: 626 GT---RSRTRSPSRTPSPSYHSRSSSESGG 652



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 108/500 (21%), Positives = 184/500 (36%), Gaps = 88/500 (17%)

Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAA 178
           RG +  R    ++++ S  P+ + +K    G   R    ++  +     S G   P +  
Sbjct: 149 RGHRGYRTKHWSSSSASPPPKKKKKKK---GGHRRSRKKRRLESEC---SCGSSSPLRK- 201

Query: 179 AAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSR 238
               K +S KK RR  + S     ++ R R +K +    R  + K+ +RP   + G +S 
Sbjct: 202 ----KKKSVKKHRRDRSDSGSRRKRRHRSRSSKCK----RKEKNKEKKRPHTESPGRRSH 253

Query: 239 R---GGGKKPQ----------------KQRRRGQKAA---TGGKSRVGKSRGGGDKKLRR 276
           R   G    P                 K R  G+K     + G      S G G    +R
Sbjct: 254 RHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQR 313

Query: 277 QGQNAALAGAK---------------------RRGAATAGEKPAAKGRGGRGPKSLGGQN 315
            G +   +GA                      R  AA A   P A+G+    P+S     
Sbjct: 314 NGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQ 373

Query: 316 PRWGR-----GGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRR 370
            R GR     G ++ RRR ++ ++++A+  +R G  + + A     SR   R R      
Sbjct: 374 GRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSD-- 431

Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRR 430
              S +G  + G G + G      RG G    R +    RA+ A  +   G   ++    
Sbjct: 432 ---SGSGRGAPGPGPEPG----SERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPE 484

Query: 431 GPKAAKSRGGKSRS-GGGKKPRRRGQKARQKAAEAGAESRGDKK--------QGRQKASA 481
           G  +++S G   RS    + P +   ++ +K   + + S   KK        +GR + S 
Sbjct: 485 GKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSE 544

Query: 482 AGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQP-RRQKPAVAGAKSRV 540
           A         +S+S     RR   +     + T+A      RK+P    +P+ + + S +
Sbjct: 545 AEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSA------RKRPIPYYRPSPSSSSSCL 598

Query: 541 GGSKSRQRQKAVAAGATSHG 560
               S +      +   SHG
Sbjct: 599 SSDYSTRSHSRSPSPGHSHG 618



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 91/404 (22%), Positives = 146/404 (36%), Gaps = 68/404 (16%)

Query: 441 KSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLW 500
           K + GG     RR +K R+  +E    S G     R+K  +     R    +S SG    
Sbjct: 172 KKKKGG----HRRSRKKRRLESEC---SCGSSSPLRKKKKSVKKHRRD---RSDSGSRRK 221

Query: 501 RRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHG 560
           RR +   +  ++      K++ +K+P  + P     +   G S S           +SH 
Sbjct: 222 RRHRSRSSKCKRKE----KNKEKKRPHTESPGRRSHRHSSGSSHS--------PSLSSHY 269

Query: 561 GGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK 620
                 SR      P+   +       R  G + P     +   +  R+G  G+++    
Sbjct: 270 SDSRSPSR----LSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAH- 324

Query: 621 AAGTGAKSRKKPWRRGQKDAAAAEKAWATGAT--SRGSGGKQPRWQKPAAAGSESSAAAA 678
             G    +   P +         +KA A   T  +RG     PR   P++ G    AA  
Sbjct: 325 -GGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPR-SAPSSQGRGGRAAGG 382

Query: 679 VGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAK 738
            G+    R++ RRRR +SR            P +R  ++PR    RG   + SR    + 
Sbjct: 383 AGR----RRRRRRRRRRSRSSASA-------PRRRGRRRPRPAPPRGSSRSLSRARSSSD 431

Query: 739 SRGSGGAKSRSGKKAAASKSHGGGG--AKRR-----------------RGGGAKSRSGEK 779
           S GSG      G +  + + HGG G  AK R                 R GG + +S  +
Sbjct: 432 S-GSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSR 490

Query: 780 AVTAGGQKAAAAGGKKPPRVKSRGG----RGQKAAAGGKKPLRR 819
             + G    + +  + P + +SR           +   KKPL R
Sbjct: 491 --SPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSR 532



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 111/510 (21%), Positives = 188/510 (36%), Gaps = 89/510 (17%)

Query: 57  KKLRRQKAAAGGKKARLRGQKGAVA-----GKEARQHWQKAAGAGGAENRGGGEQKAAAA 111
           KK RR ++ +G ++ R    + +        KE ++   ++ G     +  G     + +
Sbjct: 207 KKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLS 266

Query: 112 G----TKSLGGRGRKPRRRGQKAAA---TGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAA 164
                ++S      K R  G+K  +   +GS+ P         +  +N G+G Q++ A  
Sbjct: 267 SHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSG-QRSGAHG 325

Query: 165 GVKSQGGEKPQKAAAAGAKSR-----SGKKPRRRGAKS---RGDEDKKGRQREAKSRFGK 216
           G        P K ++   + R     +   P  RG +S   R     +GR   A    G+
Sbjct: 326 GRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGR 385

Query: 217 TRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSR-VGKSRGGGDKKLR 275
            R  RR+  RR   ++  A  RRG        RRR + A   G SR + ++R   D    
Sbjct: 386 RRRRRRR--RRRSRSSASAPRRRG--------RRRPRPAPPRGSSRSLSRARSSSD---- 431

Query: 276 RQGQNAALAGAKRRGAATAGEKPAA-KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATK 334
                        RGA   G +P + +G GG G ++            + PR R    + 
Sbjct: 432 ---------SGSGRGAPGPGPEPGSERGHGGHGKRA----------KERPPRARPASTSP 472

Query: 335 AAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
           +  A  +RG          G + +   R  G  PR   +S + +KSR        R A++
Sbjct: 473 SPGAHGRRG----------GPEGKSSSRSPGPHPRSWSSSRSPSKSRS-------RSAEK 515

Query: 395 RGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRG 454
           R            R  + K P ++ +  G  + R    +A ++R  +SRS    + RRR 
Sbjct: 516 RPHSPS-------RSPSPKKPLSRDK-DGEGRARHSEAEATRAR-RRSRSYSPIRKRRRD 566

Query: 455 QKARQKAAE-AGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA 513
             +  +      A  R         +S++   S     +SHS     R      + G  +
Sbjct: 567 SPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHS-----RSPSPGHSHGSYS 621

Query: 514 TAA-GAKSRGRKQPRRQKPAVAGAKSRVGG 542
           + + G +SR R   R   P+     S   G
Sbjct: 622 SRSHGTRSRTRSPSRTPSPSYHSRSSSESG 651



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 67/316 (21%), Positives = 113/316 (35%), Gaps = 22/316 (6%)

Query: 500 WRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH 559
           W     +    +K    G   R RK+ R +     G+ S +     R+++K+V       
Sbjct: 159 WSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPL-----RKKKKSVKKHRRDR 213

Query: 560 GGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQ 619
              G+++ R       +         K +    K+P  +       +  SG     +   
Sbjct: 214 SDSGSRRKRRHRSRSSK------CKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSS 267

Query: 620 KAAGTGAKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAA 677
             + + + SR  P  R  G+K  +       + + S GSG   P  Q+   +G  S A  
Sbjct: 268 HYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSP--QRNGGSGQRSGAHG 325

Query: 678 AVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKK---PRLG-KSRGGGGAKSRG 733
             G+   A   P +  + S     + AA    P   RGK+   PR    S+G GG  + G
Sbjct: 326 --GRPGSAHSPPDKPSSPSPRVRDKAAAAAPTP-PARGKESPSPRSAPSSQGRGGRAAGG 382

Query: 734 SGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGG 793
           +G  + R     +SRS   A   +          RG          +  +G  + A   G
Sbjct: 383 AGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPG 442

Query: 794 KKPPRVKSRGGRGQKA 809
            +P   +  GG G++A
Sbjct: 443 PEPGSERGHGGHGKRA 458


>gi|239756562 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 235

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 68/171 (39%), Positives = 80/171 (46%), Gaps = 34/171 (19%)

Query: 286 AKRRGAATAGEKPAAKGRG--GRGPKSLGGQNPRWGRGGKK--PRRRGQKATKAAAAGTK 341
           A+RR    A  K  + GR   G+GP S       W R   +  P +   +A         
Sbjct: 80  AERRSMQAAAAKAGSPGRRRVGKGPPS----RESWTRSAPQRCPSQDAGRAGSRVCRSRP 135

Query: 342 RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
           +  GGQ KAA  G K R      GK+PRRQK +AAGAKSRGG   K              
Sbjct: 136 QSRGGQ-KAAASGAKRRGVG---GKEPRRQKPAAAGAKSRGGKSHK-------------- 177

Query: 402 PRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRR 452
                PRRR QKA  AK  GGG  KP++     AK+RGG    GGGKKPRR
Sbjct: 178 ----KPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGG----GGGKKPRR 220



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 71/191 (37%), Positives = 95/191 (49%), Gaps = 27/191 (14%)

Query: 322 GKKP--RRRGQKATKAAAAG--TKRGGGGQQKAAVVGVKSRKKQRRR-GKKPRRQKASAA 376
           G++P    RG++ T A A    + RG   ++       K+    RRR GK P  +++   
Sbjct: 53  GRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTR 112

Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKA-- 434
            A  R        ++A R G    + R Q+   +   A  AK RG G K+PRR+ P A  
Sbjct: 113 SAPQRCPS-----QDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAG 167

Query: 435 AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
           AKSRGGKS     KKPRRRGQKA      A A++ G      QKA+AAG K+RGGG    
Sbjct: 168 AKSRGGKSH----KKPRRRGQKA------APAKNSGGGGNKPQKAAAAGAKNRGGG---- 213

Query: 495 SGKNLWRRGQK 505
            G    RRG++
Sbjct: 214 -GGKKPRRGRR 223



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 65/183 (35%), Positives = 85/183 (46%), Gaps = 24/183 (13%)

Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
           +R A + P A  RG      RR  P  A        S  G+  RR  Q A  KA   G  
Sbjct: 49  QRPAGRRPCASHRG------RRITPATALLL----LSHRGRAERRSMQAAAAKAGSPGRR 98

Query: 468 SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRG--RKQ 525
             G     R+  + +  +         +G  + R   ++   G+KA A+GAK RG   K+
Sbjct: 99  RVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRG-GQKAAASGAKRRGVGGKE 157

Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKA-VAAGATSHGGGGNKQSR----------GGGGNK 574
           PRRQKPA AGAKSR G S  + R++   AA A + GGGGNK  +          GGGG K
Sbjct: 158 PRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKK 217

Query: 575 PRQ 577
           PR+
Sbjct: 218 PRR 220



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 61/180 (33%), Positives = 79/180 (43%), Gaps = 30/180 (16%)

Query: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
           RR  PA         G  + +  +    KA + G+ RVGK     +   R   Q      
Sbjct: 63  RRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPSQD 122

Query: 286 AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
           A R G+     +P ++G    G K+      R G GGK+PRR+     K AAAG K  GG
Sbjct: 123 AGRAGSRVCRSRPQSRG----GQKAAASGAKRRGVGGKEPRRQ-----KPAAAGAKSRGG 173

Query: 346 GQQKAAVVGVKSRKKQRRRGKKP-----------RRQKASAAGAKSRGGGDKKGLREAKR 394
                     KS KK RRRG+K            + QKA+AAGAK+RGGG  K  R  +R
Sbjct: 174 ----------KSHKKPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKKPRRGRR 223



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 62/165 (37%), Positives = 86/165 (52%), Gaps = 31/165 (18%)

Query: 100 NRGGGEQKAAAAGTKSLGGRGRKPRRRG--QKAAATGSKKPRWRAQKSAAAGSK-----N 152
           +RG  E+++  A     G  GR+   +G   + + T S   R  +Q +  AGS+      
Sbjct: 76  HRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRP 135

Query: 153 RGAGAQKAAAA-AGVKSQGGEKP--QKAAAAGAKSRSGK---KPRRRGAKSRGDEDKKGR 206
           +  G QKAAA+ A  +  GG++P  QK AAAGAKSR GK   KPRRRG K+   ++  G 
Sbjct: 136 QSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGG- 194

Query: 207 QREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG-KKPQKQRR 250
                       GG + +    K AA GAK+R GGG KKP++ RR
Sbjct: 195 ------------GGNKPQ----KAAAAGAKNRGGGGGKKPRRGRR 223



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 67/185 (36%), Positives = 84/185 (45%), Gaps = 29/185 (15%)

Query: 150 SKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS-GKKPRRRGAKSRGDEDKKGRQR 208
           + +RG     A A   +  +G  + +   AA AK+ S G++   +G  SR    +   QR
Sbjct: 58  ASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQR 117

Query: 209 EAKSRFGKTRGGRRKKHRRP------KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSR 262
                 G  R G R    RP      K AA GAK R  GGK+P++Q+     AA G KSR
Sbjct: 118 CPSQDAG--RAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQK----PAAAGAKSR 171

Query: 263 VGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGG 322
            GKS     KK RR+GQ AA A     G     +K AA G   RG           G GG
Sbjct: 172 GGKSH----KKPRRRGQKAAPA-KNSGGGGNKPQKAAAAGAKNRG-----------GGGG 215

Query: 323 KKPRR 327
           KKPRR
Sbjct: 216 KKPRR 220



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 58/174 (33%), Positives = 76/174 (43%), Gaps = 16/174 (9%)

Query: 104 GEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA 163
           G +   A     L  RGR  RR  Q AAA      R R  K   +      +  Q+  + 
Sbjct: 62  GRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPS- 120

Query: 164 AGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGR-R 222
                  G    +   +  +SR G+K    GAK RG   K+ R+++  +   K+RGG+  
Sbjct: 121 ----QDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSH 176

Query: 223 KKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
           KK RR    A  AK+  GGG KPQK       AA G K+R     GGG KK RR
Sbjct: 177 KKPRRRGQKAAPAKNSGGGGNKPQK------AAAAGAKNR----GGGGGKKPRR 220



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 69/228 (30%), Positives = 100/228 (43%), Gaps = 57/228 (25%)

Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
           Q+PA    +      + R+   A A    SH G   ++S              AAAAK  
Sbjct: 49  QRPA---GRRPCASHRGRRITPATALLLLSHRGRAERRS------------MQAAAAKAG 93

Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAK-SRKKPWRRGQKDAAAAEKAW 647
             G ++ G    +    +S +    ++   Q A   G++  R +P  RG       +KA 
Sbjct: 94  SPGRRRVGKGPPSR---ESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRG------GQKAA 144

Query: 648 ATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVG 707
           A+GA  RG GGK+PR QKPAAAG++S       +  ++ KKPR                 
Sbjct: 145 ASGAKRRGVGGKEPRRQKPAAAGAKS-------RGGKSHKKPR----------------- 180

Query: 708 INPWQRRGKKPRLGKSRGGGGAKSR--GSGGAKSRGSGGAKS-RSGKK 752
                RRG+K    K+ GGGG K +   + GAK+RG GG K  R G++
Sbjct: 181 -----RRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKKPRRGRR 223



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 41/86 (47%), Positives = 51/86 (59%), Gaps = 5/86 (5%)

Query: 44  AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
           AAA+G K  G G K+ RRQK AA G K+R     G  + K+ R+  QKAA A  +   G 
Sbjct: 143 AAASGAKRRGVGGKEPRRQKPAAAGAKSR-----GGKSHKKPRRRGQKAAPAKNSGGGGN 197

Query: 104 GEQKAAAAGTKSLGGRGRKPRRRGQK 129
             QKAAAAG K+ GG G K  RRG++
Sbjct: 198 KPQKAAAAGAKNRGGGGGKKPRRGRR 223



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 67/199 (33%), Positives = 93/199 (46%), Gaps = 37/199 (18%)

Query: 361 QRRRGKKP----RRQKASAAGA----KSRGGGDKKGLREA--KRRGDGRKKPRWQNPRRR 410
           QR  G++P    R ++ + A A      RG  +++ ++ A  K    GR++     P R 
Sbjct: 49  QRPAGRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRE 108

Query: 411 AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG 470
           +    A  P+   S+   R G +  +SR    +S GG+K    G K R           G
Sbjct: 109 SWTRSA--PQRCPSQDAGRAGSRVCRSR---PQSRGGQKAAASGAKRR---------GVG 154

Query: 471 DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
            K+  RQK +AAG KSRGG  KSH  K   RRGQK         AA AK+ G    + QK
Sbjct: 155 GKEPRRQKPAAAGAKSRGG--KSH--KKPRRRGQK---------AAPAKNSGGGGNKPQK 201

Query: 531 PAVAGAKSRVGGSKSRQRQ 549
            A AGAK+R GG   + R+
Sbjct: 202 AAAAGAKNRGGGGGKKPRR 220



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/199 (35%), Positives = 82/199 (41%), Gaps = 45/199 (22%)

Query: 506 AEAAGEKATAAGA----KSRGRKQPRRQKPAVAGAKS----RVG-GSKSRQRQKAVAAGA 556
           A   G + T A A      RGR + R  + A A A S    RVG G  SR+     A   
Sbjct: 58  ASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQR 117

Query: 557 TSHGGGGNKQSRGGGGNKPRQWGQTAAA--AKTRGGGDKQPGWQKAAAGVTKSRSGDGGK 614
                 G   SR        + GQ AAA  AK RG G K+P  QK AA   KSR      
Sbjct: 118 CPSQDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSR------ 171

Query: 615 KAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESS 674
                     G KS KKP RRGQK         A  A + G GG +P  QK AAAG+++ 
Sbjct: 172 ----------GGKSHKKPRRRGQK---------AAPAKNSGGGGNKP--QKAAAAGAKNR 210

Query: 675 AAAAVGQEAEARKKPRRRR 693
                       KKPRR R
Sbjct: 211 GGG-------GGKKPRRGR 222



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 57/201 (28%), Positives = 85/201 (42%), Gaps = 29/201 (14%)

Query: 636 GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK 695
           G + A AA++     A  +   G++P         + ++A   +     A ++  +  A 
Sbjct: 31  GAQPAQAADEVLELPALLQRPAGRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAA 90

Query: 696 SRGDGGQNAAVGINP-----WQRRGKKPRLGKSRGGGGAK-------SRG-----SGGAK 738
             G  G+   VG  P     W R   +    +  G  G++       SRG     + GAK
Sbjct: 91  KAGSPGRRR-VGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRGGQKAAASGAK 149

Query: 739 SRGSGGAKSRSGKKAAA-SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
            RG GG + R  K AAA +KS GG   K+ R      R G+KA  A   K +  GG KP 
Sbjct: 150 RRGVGGKEPRRQKPAAAGAKSRGGKSHKKPR------RRGQKAAPA---KNSGGGGNKPQ 200

Query: 798 RVKSRGGRGQKAAAGGKKPLR 818
           +  + G +  +   GGKKP R
Sbjct: 201 KAAAAGAK-NRGGGGGKKPRR 220



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 45/177 (25%), Positives = 74/177 (41%), Gaps = 29/177 (16%)

Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSR----- 654
           A A +  S  G   +++ +  AA  G+     P RR       + ++W   A  R     
Sbjct: 68  ATALLLLSHRGRAERRSMQAAAAKAGS-----PGRRRVGKGPPSRESWTRSAPQRCPSQD 122

Query: 655 -GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR 713
            G  G +    +P + G + +AA+   +     K+PRR++  + G   +       P +R
Sbjct: 123 AGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKP-RR 181

Query: 714 RGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770
           RG+K    K+ GGGG K + +                  AA +K+ GGGG K+ R G
Sbjct: 182 RGQKAAPAKNSGGGGNKPQKAA-----------------AAGAKNRGGGGGKKPRRG 221



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/177 (31%), Positives = 77/177 (43%), Gaps = 32/177 (18%)

Query: 667 AAAGSESSAAAAVGQEAEAR-KKPRRRRAKSRGDGGQ-NAAVGINPWQRRGKKPRLGKSR 724
           +A G++ + AA    E  A  ++P  RR  +   G +   A  +     RG+  R  +S 
Sbjct: 28  SALGAQPAQAADEVLELPALLQRPAGRRPCASHRGRRITPATALLLLSHRGRAER--RSM 85

Query: 725 GGGGAKSRGSGGAKSRGSGGAK----SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780
               AK+ GS G +  G G       +RS  +   S+  G  G++  R    +SR G+KA
Sbjct: 86  QAAAAKA-GSPGRRRVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSR-PQSRGGQKA 143

Query: 781 VTAGGQKAAAAGGKKPPR-------VKSRGG--------RGQKAA------AGGKKP 816
             A G K    GGK+P R        KSRGG        RGQKAA       GG KP
Sbjct: 144 -AASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGGGGNKP 199


>gi|239754474 PREDICTED: similar to mucin [Homo sapiens]
          Length = 417

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 120/451 (26%), Positives = 181/451 (40%), Gaps = 81/451 (17%)

Query: 272 KKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQK 331
           +KLR   +       ++       ++P  +  GG G +   G +P   + G + R   ++
Sbjct: 13  RKLRESSEGDQWLENEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDRE--EE 70

Query: 332 ATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLRE 391
           A  A AA  +R    +++AA   V +    R   +K  + +   AG    G G ++G R 
Sbjct: 71  AAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAG----GTGQRRGSRS 126

Query: 392 AKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPR 451
           +      R + R       A  AP    RG  ++K +R+ P+   + G   R G G  P 
Sbjct: 127 SPSADQQRAQDR----EEEAAAAPVPTSRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPS 182

Query: 452 RRGQKARQKAAEAGAE----SRGDKKQGR-----QKASAAGTKSRGGGLKSHSGKNLWRR 502
              Q A+ +  EA A     SRG + + R     Q   A GT  R G   S S       
Sbjct: 183 ADQQGAQDREEEAAAAPAPTSRGHRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQ---- 238

Query: 503 GQKAEAAGEKATAAGAK-SRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGG 561
            Q+A+   E+A AA A  SRG +  +R               K +Q Q+  A        
Sbjct: 239 -QRAQDREEEAAAAPAPTSRGHRTEKR---------------KPQQPQRRPA-------- 274

Query: 562 GGNKQSRGGG--------GNKPRQWGQTAAAAKTRGG----GDKQPGWQKAAAGVTKSRS 609
           GG  Q RG G        G + R+    AA A T  G      K+   Q   AG T  R 
Sbjct: 275 GGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRR 334

Query: 610 GDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAA 669
           G G   +  Q+    GA+ R       +++AAAA    ++G  +     +QP+ ++PAA 
Sbjct: 335 GSGCSSSANQQ----GAQDR-------EEEAAAAPVPTSSGHRTEKRKPQQPQ-RRPAAG 382

Query: 670 -----GSESSAAA----AVGQEAEARKKPRR 691
                GS SS +A    A  +E E RK  +R
Sbjct: 383 TGQRRGSGSSPSADQQRAQDREEEVRKWKKR 413



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 83/353 (23%), Positives = 147/353 (41%), Gaps = 33/353 (9%)

Query: 82  GKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWR 141
           G + R+    AA A   +     E++AAAA   +  G   + R+R Q          + R
Sbjct: 63  GAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRR 122

Query: 142 AQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSR-SGKKPRRRGAKSRGD 200
             +S+ +  + R    ++ AAAA V +  G + +K      + R +G   +RRG+ S   
Sbjct: 123 GSRSSPSADQQRAQDREEEAAAAPVPTSRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPS 182

Query: 201 EDKKG---RQREAKSRFGKTRGGRRKKHRRPKP----AAGGAKSRRGGGKKPQKQRRRGQ 253
            D++G   R+ EA +    T  G R + R+P+      AGG   RRG    P   ++R Q
Sbjct: 183 ADQQGAQDREEEAAAAPAPTSRGHRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQ 242

Query: 254 -KAATGGKSRVGKSRGGGDKKLRRQGQNAALAG--AKRRGAATAGEKPAAKGRGGRGPKS 310
            +      +    SRG   +K + Q      AG   +RRG   +G  P+A  +G +  + 
Sbjct: 243 DREEEAAAAPAPTSRGHRTEKRKPQQPQRRPAGGTGQRRG---SGYSPSADQQGAQDREE 299

Query: 311 LGGQNPRWGRGGKKPRRRGQ---KATKAAAAGTKRGGGGQQKAAVVGVKSRKK------- 360
                P     G +  +R +   +   A   G +RG G    A   G + R++       
Sbjct: 300 EAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSGCSSSANQQGAQDREEEAAAAPV 359

Query: 361 --------QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQ 405
                   ++R+ ++P+R+ A+  G + RG G      + + +    +  +W+
Sbjct: 360 PTSSGHRTEKRKPQQPQRRPAAGTGQR-RGSGSSPSADQQRAQDREEEVRKWK 411



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 109/452 (24%), Positives = 185/452 (40%), Gaps = 75/452 (16%)

Query: 204 KGRQREAKSRFGKTR----GGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGG 259
           K RQ+E  +R  K R    G +  ++ + KP             +PQ+Q +      TG 
Sbjct: 2   KPRQKEQDTRLRKLRESSEGDQWLENEKTKPL------------RPQQQPQCQPAGGTGQ 49

Query: 260 KSRVGKSRGGGDKKLRRQGQNAALAGA-------KRRGAATAGEKPAAKGRGGRGPKSLG 312
           +   G S     +  + + + AA A A        R   A A   P + G      K L 
Sbjct: 50  RRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQ 109

Query: 313 GQ-NPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGV---KSRKKQRRRGKKP 368
            Q  P  G G    +RRG ++  + +A  +R    +++AA   V   +  + ++R+ ++P
Sbjct: 110 LQCQPAGGTG----QRRGSRS--SPSADQQRAQDREEEAAAAPVPTSRGHRTEKRKRQQP 163

Query: 369 RRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPR 428
           +R+ A   G + RG G       A ++G        Q+    A  APA   RG  ++K +
Sbjct: 164 QRRPAGGTGQR-RGSGSSP---SADQQGA-------QDREEEAAAAPAPTSRGHRTEKRK 212

Query: 429 RRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGA----ESRGDKKQGR-----QKA 479
            + P+   + G   R G    P    Q+A+ +  EA A     SRG + + R     Q+ 
Sbjct: 213 PQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRKPQQPQRR 272

Query: 480 SAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA-TAAGAKSRGRKQPRRQKPAVAGAKS 538
            A GT  R G   S S      + ++ EAA   A T++G ++  RK+ + Q     G   
Sbjct: 273 PAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQ 332

Query: 539 RVG----------GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
           R G          G++ R+ + A A   TS G    K+       KP+Q  +  AA    
Sbjct: 333 RRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEKR-------KPQQPQRRPAA---- 381

Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK 620
           G G ++      +A   +++  +   + W+++
Sbjct: 382 GTGQRRGSGSSPSADQQRAQDREEEVRKWKKR 413



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 97/403 (24%), Positives = 164/403 (40%), Gaps = 38/403 (9%)

Query: 107 KAAAAGTKSLGGRGRKPRRRGQK-----AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
           + ++ G + L     KP R  Q+     A  TG ++    +  +   G+++R   A  AA
Sbjct: 16  RESSEGDQWLENEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDREEEA--AA 73

Query: 162 AAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGR 221
           A A  + +  ++ ++AAAA   + SG +  +R       +   G  +   SR   +   +
Sbjct: 74  APAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSADQQ 133

Query: 222 RKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNA 281
           R + R  + AA    + R G +  +++R++ Q+   GG    G+ RG G         +A
Sbjct: 134 RAQDREEEAAAAPVPTSR-GHRTEKRKRQQPQRRPAGG---TGQRRGSG------SSPSA 183

Query: 282 ALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
              GA+ R    A   PA   RG R  K    Q P+    G   +RRG ++  + +A  +
Sbjct: 184 DQQGAQDR-EEEAAAAPAPTSRGHRTEKR-KPQQPQCRPAGGTGQRRGSRS--SPSADQQ 239

Query: 342 RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
           R    +++AA     + +  R   +KP++ +   AG    G G ++G            +
Sbjct: 240 RAQDREEEAAAAPAPTSRGHRTEKRKPQQPQRRPAG----GTGQRRG----SGYSPSADQ 291

Query: 402 PRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA 461
              Q+    A  APA    G  ++K +R   +   + G   R G G       Q A+ + 
Sbjct: 292 QGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSGCSSSANQQGAQDRE 351

Query: 462 AEA---------GAESRGDKKQGRQKASAAGTKSRGGGLKSHS 495
            EA         G  +   K Q  Q+  AAGT  R G   S S
Sbjct: 352 EEAAAAPVPTSSGHRTEKRKPQQPQRRPAAGTGQRRGSGSSPS 394



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 101/394 (25%), Positives = 163/394 (41%), Gaps = 55/394 (13%)

Query: 8   QCNQAAG---RAGPGAPLGAALARTPVELAAESAAPALSA---------AAAGVKILGSG 55
           QC  A G   R G G+   A            +AAPA            AAA      SG
Sbjct: 40  QCQPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSG 99

Query: 56  DKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKS 115
            +  +R       K+ +L+ Q     G+        +A    A++R   E++AAAA   +
Sbjct: 100 HRTEKR-------KRLQLQCQPAGGTGQRRGSRSSPSADQQRAQDR---EEEAAAAPVPT 149

Query: 116 LGGRGRKPRRRGQK----AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG 171
             G   + R+R Q     A  TG ++    +  +   G+++R    ++ AAAA   +  G
Sbjct: 150 SRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPSADQQGAQDR----EEEAAAAPAPTSRG 205

Query: 172 EKPQKAAAAGAKSR-SGKKPRRRGAKSRGDEDK---KGRQREAKSRFGKTRGGRRKKHRR 227
            + +K      + R +G   +RRG++S    D+   + R+ EA +    T  G R + R+
Sbjct: 206 HRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRK 265

Query: 228 P----KPAAGGAKSRRGGGKKP----QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQ 279
           P    +  AGG   RRG G  P    Q  + R ++AA          R    K+L+ Q Q
Sbjct: 266 PQQPQRRPAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQ 325

Query: 280 NAALAGAKR-RGAATAGEKPAAKGRGGRG-----PKSLGGQNPRWGRGGKKPRRRGQKAT 333
            A   G +R  G +++  +  A+ R         P S G +  +  R  ++P+RR     
Sbjct: 326 PAGGTGQRRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEK--RKPQQPQRR----- 378

Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKK 367
            AA  G +RG G    A     + R+++ R+ KK
Sbjct: 379 PAAGTGQRRGSGSSPSADQQRAQDREEEVRKWKK 412



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 87/378 (23%), Positives = 141/378 (37%), Gaps = 31/378 (8%)

Query: 426 KPRR--RGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKK--QGRQKASA 481
           KP R  + P+   + G   R G G  P    Q A+ +  EA A    D++  Q R++ +A
Sbjct: 31  KPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAA 90

Query: 482 AGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKS--RGRKQPRRQKPAVAGAKS- 538
           A       G ++   K L  + Q A   G++  +  + S  + R Q R ++ A A   + 
Sbjct: 91  AAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPVPTS 150

Query: 539 ---RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGG---- 591
              R    K +Q Q+  A G     G G+  S    G + R+    AA A T  G     
Sbjct: 151 RGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAPTSRGHRTEK 210

Query: 592 --DKQPGWQKAAA-----GVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAE 644
              +QP  + A       G   S S D  +   R++ A        +  R  ++     +
Sbjct: 211 RKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRKPQQPQ 270

Query: 645 KAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR--AKSRGDGGQ 702
           +  A G   R   G  P   +  A   E  AAAA    +   +  +R+R   + +  GG 
Sbjct: 271 RRPAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGT 330

Query: 703 NAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGG 762
                    QRRG       ++ G   +   +  A    S G ++   K     +    G
Sbjct: 331 G--------QRRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEKRKPQQPQRRPAAG 382

Query: 763 GAKRRRGGGAKSRSGEKA 780
             +RR  G + S   ++A
Sbjct: 383 TGQRRGSGSSPSADQQRA 400


>gi|239752579 PREDICTED: hypothetical protein XP_002348295 [Homo
           sapiens]
          Length = 240

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 69/171 (40%), Positives = 85/171 (49%), Gaps = 19/171 (11%)

Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRW---QNPRRRAQKAPAAKP- 419
           RG+  RR   +AA  +   G    G     R    R  PR    Q+  R   +   ++P 
Sbjct: 84  RGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQ 143

Query: 420 -RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQK 478
            RG G KK R+RG KAA     K+ SG  KKP       RQKAA  GA+SRG + +  QK
Sbjct: 144 TRGSGGKKLRQRGEKAAAV---KTCSGRSKKP------GRQKAAVMGAKSRGGRGKKPQK 194

Query: 479 ASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
           A+AAG KS  GG     GK L R G+K    G+KA   GAKSR + Q R Q
Sbjct: 195 AAAAGAKSCNGG-----GKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 64/163 (39%), Positives = 81/163 (49%), Gaps = 12/163 (7%)

Query: 141 RAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGD 200
           R+  +AAA  ++ G G          +S     P+   +  A SRSG +  R   ++RG 
Sbjct: 90  RSMHAAAAQERSLGRGCL-GKEPPNRESWTRSDPRHCISQDA-SRSGSRVCRSRPQTRGS 147

Query: 201 EDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGK 260
             KK RQR  K+   KT  GR KK  R K A  GAKSR G GKKPQK    G K+  GG 
Sbjct: 148 GGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGAKSCNGG- 206

Query: 261 SRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGR 303
              GK  G   KK  R+GQ AA+ GAK R      +KP  +G+
Sbjct: 207 ---GKKLGRWGKKPGRRGQKAAVTGAKSR------KKPQRRGQ 240



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 63/166 (37%), Positives = 79/166 (47%), Gaps = 19/166 (11%)

Query: 493 SHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAV 552
           SH G+   RR   A AA E++   G    G++ P R+    +  +  +    SR   +  
Sbjct: 82  SHRGR-AQRRSMHAAAAQERSLGRGCL--GKEPPNRESWTRSDPRHCISQDASRSGSRVC 138

Query: 553 AAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDG 612
            +           Q+RG GG K RQ G+ AAA KT  G  K+PG QKAA    KSR G G
Sbjct: 139 RS---------RPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRG 189

Query: 613 GKKAWRQKAAGTGAKS----RKKPWRRGQKDAAAAEKAWATGATSR 654
            K    QKAA  GAKS     KK  R G+K     +KA  TGA SR
Sbjct: 190 KKP---QKAAAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSR 232



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 72/214 (33%), Positives = 91/214 (42%), Gaps = 64/214 (29%)

Query: 247 KQRRRGQKAATG-----GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
           + +RR   AA       G+  +GK     +   R   ++     A R G+     +P  +
Sbjct: 86  RAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQTR 145

Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQ 361
           G GG                 KK R+RG+KA        +    G+QKAAV+G KSR   
Sbjct: 146 GSGG-----------------KKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSR--- 185

Query: 362 RRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
             RGKKP  QKA+AAGAKS  GG             G+K  RW                 
Sbjct: 186 GGRGKKP--QKAAAAGAKSCNGG-------------GKKLGRW----------------- 213

Query: 422 GGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQ 455
              KKP RRG KAA + G KSR    KKP+RRGQ
Sbjct: 214 --GKKPGRRGQKAAVT-GAKSR----KKPQRRGQ 240



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 74/229 (32%), Positives = 92/229 (40%), Gaps = 60/229 (26%)

Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR 469
           R   A A  P     +  RR    AA       R   GK+P  R    R       ++  
Sbjct: 71  RVTPATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQ-- 128

Query: 470 GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
            D  +   +   +  ++RG G            G+K    GEKA A    S   K+P RQ
Sbjct: 129 -DASRSGSRVCRSRPQTRGSG------------GKKLRQRGEKAAAVKTCSGRSKKPGRQ 175

Query: 530 KPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
           K AV GAKSR  G + ++ QKA AAGA + +          GGG K  +WG         
Sbjct: 176 KAAVMGAKSR--GGRGKKPQKAAAAGAKSCN----------GGGKKLGRWG--------- 214

Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQ 637
               K+PG           R G        QKAA TGAKSRKKP RRGQ
Sbjct: 215 ----KKPG-----------RRG--------QKAAVTGAKSRKKPQRRGQ 240



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 58/160 (36%), Positives = 74/160 (46%), Gaps = 17/160 (10%)

Query: 1   MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
           + +RG  Q       A     LG   L + P    + + +      +      GS   + 
Sbjct: 81  LSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRS 140

Query: 60  RRQKAAAGGKKARLRGQKGAV----AGKEARQHWQKAA--GAGGAENRGGGEQKAAAAGT 113
           R Q   +GGKK R RG+K A     +G+  +   QKAA  GA     RG   QKAAAAG 
Sbjct: 141 RPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGA 200

Query: 114 KS-------LGGRGRKPRRRGQKAAATGS---KKPRWRAQ 143
           KS       LG  G+KP RRGQKAA TG+   KKP+ R Q
Sbjct: 201 KSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 65/182 (35%), Positives = 92/182 (50%), Gaps = 43/182 (23%)

Query: 42  LSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA--RQHWQKAAGAGGAE 99
           ++ A A + +   G  + R   AAA  +++  RG      GKE   R+ W ++      +
Sbjct: 72  VTPATALLPLSHRGRAQRRSMHAAAAQERSLGRG----CLGKEPPNRESWTRS------D 121

Query: 100 NRGGGEQKAAAAGTK-------SLGGRGRKPRRRGQKAAATG-----SKKPRWRAQKSAA 147
            R    Q A+ +G++       + G  G+K R+RG+KAAA       SKKP    QK+A 
Sbjct: 122 PRHCISQDASRSGSRVCRSRPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPG--RQKAAV 179

Query: 148 AGSKNRGAGAQKA--AAAAGVKS---------QGGEKP----QKAAAAGAKSRSGKKPRR 192
            G+K+RG   +K   AAAAG KS         + G+KP    QKAA  GAKSR  KKP+R
Sbjct: 180 MGAKSRGGRGKKPQKAAAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSR--KKPQR 237

Query: 193 RG 194
           RG
Sbjct: 238 RG 239



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/175 (31%), Positives = 78/175 (44%), Gaps = 26/175 (14%)

Query: 629 RKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARK 687
           R +  RR    AAA E++       RG  GK+P  ++   + + S     + Q+A  +  
Sbjct: 84  RGRAQRRSMHAAAAQERS-----LGRGCLGKEPPNRE---SWTRSDPRHCISQDASRSGS 135

Query: 688 KPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGG----GAKSRGSGGAKSRGSG 743
           +  R R ++RG GG+         ++RG+K    K+  G     G +     GAKSRG  
Sbjct: 136 RVCRSRPQTRGSGGKKL-------RQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGR 188

Query: 744 GAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
           G K +    AA +KS  GGG K  R G    R G+KA   G     A   KKP R
Sbjct: 189 GKKPQKA-AAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTG-----AKSRKKPQR 237



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 38/175 (21%)

Query: 100 NRGGGEQKA--AAAGTKSLGGR---GRKPRRR------------GQKAAATGSKKPRWRA 142
           +RG  ++++  AAA  +   GR   G++P  R             Q A+ +GS+  R R 
Sbjct: 83  HRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRP 142

Query: 143 QKSAAAGSKNRGAGAQKAAAAAGVKSQGG--EKP--QKAAAAGAKSRSGKKPRRRGAKSR 198
           Q   + G K R    Q+   AA VK+  G  +KP  QKAA  GAKSR G          R
Sbjct: 143 QTRGSGGKKLR----QRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGG----------R 188

Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQ 253
           G + +K     AKS  G   GG++      KP   G K+   G K  +K +RRGQ
Sbjct: 189 GKKPQKAAAAGAKSCNG---GGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 44/96 (45%), Positives = 50/96 (52%), Gaps = 14/96 (14%)

Query: 738 KSRGSGGAKSRS-GKKAAASKSHGGGGAKRRRGG----GAKSRSGE----KAVTAGGQKA 788
           ++RGSGG K R  G+KAAA K+  G   K  R      GAKSR G     +   A G K+
Sbjct: 143 QTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGAKS 202

Query: 789 AAAGGKKPPRV-KSRGGRGQKAAAGG----KKPLRR 819
              GGKK  R  K  G RGQKAA  G    KKP RR
Sbjct: 203 CNGGGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRR 238


>gi|239752632 PREDICTED: hypothetical protein XP_002347697 [Homo
           sapiens]
          Length = 231

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 72/160 (45%), Positives = 83/160 (51%), Gaps = 22/160 (13%)

Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRW---QNPRRRAQKAPAAKP- 419
           RG+  RR   +AA  +   G    G    K     R  PR    Q+  R   +   ++P 
Sbjct: 84  RGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQ 143

Query: 420 -RGGGSKKPRRRGPKA----AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
            RGGG KKP RRG KA    AKSRGG  RS GGKK RRRG    QKAA AGA+S G   +
Sbjct: 144 TRGGGGKKP-RRGQKAATAGAKSRGGGVRSRGGKKIRRRG----QKAAAAGAKSCGGGGK 198

Query: 475 GRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA-GEKA 513
             QKA A G + RG        K L RRG+KA AA GEKA
Sbjct: 199 KPQKARAVGARRRG-------WKKLRRRGKKAAAAGGEKA 231



 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 69/169 (40%), Positives = 82/169 (48%), Gaps = 31/169 (18%)

Query: 184 SRSGKKPRRRGAKSRGDEDKKGRQ---REAKSRFGKTRGGRRKKHRRPKPAAGGA----- 235
           S  G+  RR    +   E   GR    +E       TR G R+   +    +G       
Sbjct: 82  SHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSR 141

Query: 236 -KSRRGGGKKPQKQRRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAAT 293
            ++R GGGKKP    RRGQKAAT G KSR G  R  G KK+RR+GQ AA AGAK  G   
Sbjct: 142 PQTRGGGGKKP----RRGQKAATAGAKSRGGGVRSRGGKKIRRRGQKAAAAGAKSCGG-- 195

Query: 294 AGEKP-AAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
            G+KP  A+  G R             RG KK RRRG+KA  AAA G K
Sbjct: 196 GGKKPQKARAVGAR------------RRGWKKLRRRGKKA--AAAGGEK 230



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 62/166 (37%), Positives = 84/166 (50%), Gaps = 28/166 (16%)

Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARKKPRRR 692
           RR  + AAA E++   G      G + P+W+    +G        + Q+A  +  +  R 
Sbjct: 89  RRSMQAAAAQEQSLGRGCL----GKEPPKWESSTRSGPRR----CLSQDASRSGSRVCRS 140

Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKK 752
           R ++RG GG              KKPR G+     GAKSRG GG +SRG    + R  K 
Sbjct: 141 RPQTRGGGG--------------KKPRRGQKAATAGAKSRG-GGVRSRGGKKIRRRGQKA 185

Query: 753 AAA-SKSHGGGGAK--RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
           AAA +KS GGGG K  + R  GA+ R G K +   G+KAAAAGG+K
Sbjct: 186 AAAGAKSCGGGGKKPQKARAVGARRR-GWKKLRRRGKKAAAAGGEK 230



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 69/186 (37%), Positives = 83/186 (44%), Gaps = 47/186 (25%)

Query: 246 QKQRRRGQKAATG----GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
           Q QRR  Q AA      G+  +GK     +   R   +      A R G+     +P  +
Sbjct: 86  QVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQTR 145

Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR--K 359
           G GG+ P                  RRGQKA   A AG K  GGG        V+SR  K
Sbjct: 146 GGGGKKP------------------RRGQKA---ATAGAKSRGGG--------VRSRGGK 176

Query: 360 KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
           K RRRG     QKA+AAGAKS GGG KK     K R  G ++  W+  RRR +KA AA  
Sbjct: 177 KIRRRG-----QKAAAAGAKSCGGGGKK---PQKARAVGARRRGWKKLRRRGKKAAAA-- 226

Query: 420 RGGGSK 425
             GG K
Sbjct: 227 --GGEK 230



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 58/159 (36%), Positives = 78/159 (49%), Gaps = 28/159 (17%)

Query: 41  ALSAAAAGVKILGSG--DKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGA 98
           ++ AAAA  + LG G   K+  + +++      R   Q  + +G    +   +  G GG 
Sbjct: 91  SMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQTRGGGGK 150

Query: 99  ENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQ 158
           + R G  QKAA AG KS GG  R          + G KK R R QK+AAAG+K+ G G  
Sbjct: 151 KPRRG--QKAATAGAKSRGGGVR----------SRGGKKIRRRGQKAAAAGAKSCGGG-- 196

Query: 159 KAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKS 197
                       G+KPQKA A GA+ R  KK RRRG K+
Sbjct: 197 ------------GKKPQKARAVGARRRGWKKLRRRGKKA 223



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 57/166 (34%), Positives = 76/166 (45%), Gaps = 21/166 (12%)

Query: 1   MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
           + +RG  Q       A     LG   L + P +  + + +      +      GS   + 
Sbjct: 81  LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRS 140

Query: 60  RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE-----QKAAAAGTK 114
           R Q    GGKK R RGQK A AG ++R         GG  +RGG +     QKAAAAG K
Sbjct: 141 RPQTRGGGGKKPR-RGQKAATAGAKSR--------GGGVRSRGGKKIRRRGQKAAAAGAK 191

Query: 115 SLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
           S GG G+KP    QKA A G+++  W+  K    G K   AG +KA
Sbjct: 192 SCGGGGKKP----QKARAVGARRRGWK--KLRRRGKKAAAAGGEKA 231



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 72/210 (34%), Positives = 89/210 (42%), Gaps = 67/210 (31%)

Query: 82  GKEARQHWQKAAGAGGAENRG--GGEQKAAAAGTKSLGGRGRKPRR-RGQKAAATGSKKP 138
           G+  R+  Q AA    +  RG  G E     + T+S       PRR   Q A+ +GS+  
Sbjct: 85  GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRS------GPRRCLSQDASRSGSRVC 138

Query: 139 RWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSR 198
           R R Q     G K R     + AA AG KS+GG         G +SR GKK RRRG K+ 
Sbjct: 139 RSRPQTRGGGGKKPRRG---QKAATAGAKSRGG---------GVRSRGGKKIRRRGQKA- 185

Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATG 258
                                           AA GAKS  GGGKKPQK R      A G
Sbjct: 186 --------------------------------AAAGAKSCGGGGKKPQKAR------AVG 207

Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKR 288
            + R       G KKLRR+G+ AA AG ++
Sbjct: 208 ARRR-------GWKKLRRRGKKAAAAGGEK 230



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 64/183 (34%), Positives = 82/183 (44%), Gaps = 40/183 (21%)

Query: 469 RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR 528
           RG  ++   +A+AA  +S G G         W   + +  +G +   +   SR   +  R
Sbjct: 84  RGQVQRRSMQAAAAQEQSLGRGCLGKEPPK-W---ESSTRSGPRRCLSQDASRSGSRVCR 139

Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA--K 586
            +P   G     GG K R+ QKA  AGA S GGG     R  GG K R+ GQ AAAA  K
Sbjct: 140 SRPQTRGG----GGKKPRRGQKAATAGAKSRGGG----VRSRGGKKIRRRGQKAAAAGAK 191

Query: 587 TRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDAAA-A 643
           + GGG K+P                       QKA   GA+ R  KK  RRG+K AAA  
Sbjct: 192 SCGGGGKKP-----------------------QKARAVGARRRGWKKLRRRGKKAAAAGG 228

Query: 644 EKA 646
           EKA
Sbjct: 229 EKA 231



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 58/168 (34%), Positives = 75/168 (44%), Gaps = 28/168 (16%)

Query: 428 RRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSR 487
           RR    AA       R   GK+P +     R       ++   D  +   +   +  ++R
Sbjct: 89  RRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQ---DASRSGSRVCRSRPQTR 145

Query: 488 GGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR--QKPAVAGAKSRVGGSKS 545
           GGG K        RRGQKA  AG K+   G +SRG K+ RR  QK A AGAKS  GG K 
Sbjct: 146 GGGGKKP------RRGQKAATAGAKSRGGGVRSRGGKKIRRRGQKAAAAGAKSCGGGGKK 199

Query: 546 RQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDK 593
            Q+ +AV A             R  G  K R+ G+ AAAA    GG+K
Sbjct: 200 PQKARAVGA-------------RRRGWKKLRRRGKKAAAA----GGEK 230



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 55/175 (31%), Positives = 76/175 (43%), Gaps = 45/175 (25%)

Query: 657 GGKQPRWQKPAAAGSESSAAAAVGQE-----AEARKKPRRRRAKSRGDGGQNAAVGINPW 711
           G  Q R  + AAA  +S     +G+E     +  R  PRR  ++     G          
Sbjct: 85  GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGS--------- 135

Query: 712 QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGG 771
                  R+ +SR             ++RG GG K R G+KAA + +   GG  R RGG 
Sbjct: 136 -------RVCRSR------------PQTRGGGGKKPRRGQKAATAGAKSRGGGVRSRGGK 176

Query: 772 AKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR----------GQKAA-AGGKK 815
              R G+KA  AG  K+   GGKKP + ++ G R          G+KAA AGG+K
Sbjct: 177 KIRRRGQKAAAAGA-KSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEK 230



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 58/171 (33%), Positives = 72/171 (42%), Gaps = 32/171 (18%)

Query: 542 GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
           G   R+  +A AA   S G       RG  G +P +W      + TR G        +  
Sbjct: 85  GQVQRRSMQAAAAQEQSLG-------RGCLGKEPPKW-----ESSTRSG-------PRRC 125

Query: 602 AGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQP 661
                SRSG    ++  Q   G G    KKP RRGQK A A  K+   G  SRG    + 
Sbjct: 126 LSQDASRSGSRVCRSRPQTRGGGG----KKP-RRGQKAATAGAKSRGGGVRSRGGKKIRR 180

Query: 662 RWQKPAAAGSES--------SAAAAVGQEAEARKKPRRRRAKSRGDGGQNA 704
           R QK AAAG++S          A AVG      KK RRR  K+   GG+ A
Sbjct: 181 RGQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKA 231


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 117/528 (22%), Positives = 204/528 (38%), Gaps = 71/528 (13%)

Query: 329 GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG 388
           G+ A    AA ++ GG   ++  +   + R +QR     P    A+AAG  +R    KK 
Sbjct: 464 GEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR----KKS 519

Query: 389 LREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRR----GPKAAKSRGGKSRS 444
            RE KR G+ ++     +  + A  APA+      SKK R R    G  A+ S   +SRS
Sbjct: 520 RRERKRSGEAKEAASSSSGTQPAPPAPASP---WDSKKHRSRDRKPGSHASSSARRRSRS 576

Query: 445 GGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ 504
               +  RR  ++  +       SR  +K+ R++ SA+   +      S S +    RG+
Sbjct: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATS---SSSSSRRERHRGK 633

Query: 505 KAEAAGEKATAAGAKSRGRKQ-----PRRQKPAVAGAKSRVGGSKSRQRQKAV------- 552
             +  G K     ++SRG K+      +   PA   + S   G +  +R+ AV       
Sbjct: 634 HRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDL 693

Query: 553 ------AAGATSHGGGGNKQSRGGGGNKPRQ-------WGQTAAAAKTRGGGDKQPGWQK 599
                 A   T   G  +K    G    P         +     + + RGG   Q   ++
Sbjct: 694 TDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRR 753

Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
           + A  + S S + G    R+KA   G + R    R   +D   + K       S  S G 
Sbjct: 754 SGAASSSSSSREKGS---RRKALDGGDRDRD---RDRDRDRDRSSKKARPPKESAPSSGP 807

Query: 660 QPRWQKPAAAGSESSAAAAVGQEAEARKKPR---RRRAKSRGDGGQNAAVGI-------- 708
            P+    + +GS SS+++   ++ + + K     R    S       A+ G+        
Sbjct: 808 PPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFS 867

Query: 709 ------NPWQRRGKKPRLGKSRGGGGA------KSRGSGGAKSRGSGGAKSRSGKKAAAS 756
                 +P+ +  ++     ++   G+      K +   GAK       K++  K     
Sbjct: 868 RDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKV 927

Query: 757 KSHGGGGAKRRRGGGAKSRS---GEKAVTAGGQKAAAAGGKKPPRVKS 801
           +S GG G    +    KS++    + A T G ++ + +G ++  +V S
Sbjct: 928 RSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 130/542 (23%), Positives = 203/542 (37%), Gaps = 74/542 (13%)

Query: 90  QKAAGAGGAENRGGG---EQKAAAAGTKSLGGRGRKPRRRGQKAAATG------SKKPRW 140
           + A     A++R GG    +K      +    R   P      AAA G      S++ R 
Sbjct: 465 EPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERK 524

Query: 141 RAQKSAAAGSKNRGAGAQKAAAAAGVKSQG----GEKPQKAAAAGAKSRSGKKPRRRGAK 196
           R+ ++  A S + G      A A+   S+       KP   A++ A+ RS  + R R  +
Sbjct: 525 RSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTR 584

Query: 197 --SRGDEDKKGRQREAKSRFGKTRGGRRKKHRR------PKPAAGGAKSRRGGGKKPQKQ 248
             SR  + ++G  R ++SR         +K RR      P PA   + S R       ++
Sbjct: 585 RRSRSTDRRRGGSRRSRSR---------EKRRRRRRSASPPPATSSSSSSR-------RE 628

Query: 249 RRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG 307
           R RG+    GG K +  +SR  G+K+     + A        G+ + G++ +   R G  
Sbjct: 629 RHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSR--RRGAV 686

Query: 308 PKSLGGQN-------PRWGRGGKKPRRRGQKATKAAAAGTKR-------GGGGQQKAAVV 353
           P S+            R    G+  +   +  + A A+  KR       G  G+++    
Sbjct: 687 PPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEER---- 742

Query: 354 GVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD-GRKKPRWQNPRRRAQ 412
           G KS +K RRR         S A + S    +K   R+A   GD  R + R ++  R ++
Sbjct: 743 GGKSSQKDRRR---------SGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSK 793

Query: 413 KAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDK 472
           KA   K     S  P    PK   S G  S S       R+  K + K A    E     
Sbjct: 794 KARPPKESAPSSGPP----PKPPVSSGSGSSSSSSSCSSRK-VKLQSKVAVLIREGVSST 848

Query: 473 KQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPA 532
              +  AS AG  S G                   A  E A AA   ++ +K   + K  
Sbjct: 849 TPAKDAAS-AGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAG 907

Query: 533 VAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGD 592
               K   G +K  + +K V +G  S G GG    +    +   Q   T  A +T   G+
Sbjct: 908 AKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGE 967

Query: 593 KQ 594
           ++
Sbjct: 968 ER 969



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 114/486 (23%), Positives = 169/486 (34%), Gaps = 119/486 (24%)

Query: 411 AQKAPAAKPRGGG-----------SKKPRRRGPKAAKSRGGKSRSGGG-KKPRRRGQKAR 458
           A   PAA  R GG            ++ R+R P  A +    + +G   +K  RR +K  
Sbjct: 467 APAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRS 526

Query: 459 QKAAEAGAESRGDKKQGRQKASAAGTK---SRGGGLKSHSGKNLWRRGQKAEAAGEKATA 515
            +A EA + S G +      AS   +K   SR     SH+  +  RR +       ++ +
Sbjct: 527 GEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRS------RSRS 580

Query: 516 AGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS-----RGG 570
              + R R   RR+       +SR    + R+R+ A    ATS      ++      R G
Sbjct: 581 RSTRRRSRSTDRRRG---GSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDG 637

Query: 571 GGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKS-- 628
           GG+K ++        ++R  G+K              RSGDG +KA       +G+ S  
Sbjct: 638 GGSKKKK-------KRSRSRGEK--------------RSGDGSEKAPAPAPPPSGSTSCG 676

Query: 629 RKKPWRRG----------QKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGS------- 671
            +   RRG            D  A ++    G   +      PR   PA A S       
Sbjct: 677 DRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDK----SDPRGPSPAPASSPKREVLY 732

Query: 672 -----------------ESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRR 714
                            +   + A    + +R+K  RR+A   GD  ++         R 
Sbjct: 733 DSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRD-RDRDRS 791

Query: 715 GKKPRLGKSRGGGGAK------SRGSGGAKSRGS-----------------GGAKSRSGK 751
            KK R  K              S GSG + S  S                  G  S +  
Sbjct: 792 SKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPA 851

Query: 752 KAAASKSHGGGGAKRRRGGGAKS---RSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQK 808
           K AAS   G  G K  R   ++S   +  E+A T      AA G  KP + K +   G K
Sbjct: 852 KDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTE--MAKAAPGSTKPKKTKVKAKAGAK 909

Query: 809 AAAGGK 814
              G K
Sbjct: 910 KTKGTK 915



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 56/263 (21%), Positives = 89/263 (33%), Gaps = 64/263 (24%)

Query: 621 AAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ------KPAAAGSESS 674
           AA  G  +RKK  R  ++   A E A ++  T          W       +    GS +S
Sbjct: 508 AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHAS 567

Query: 675 AAAAVGQEAEARKKPRRRRAKS----RGDGGQNAAVGINPWQRRGKKP------------ 718
           ++A     + +R +  RRR++S    RG   ++ +      +RR   P            
Sbjct: 568 SSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR 627

Query: 719 --RLGKSRGGGGAKSRG----SGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGA 772
               GK R GGG+K +     S G K  G G  K+ +     +  +  G    RRRG   
Sbjct: 628 ERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVP 687

Query: 773 KSRSG---------EKAVTAG---------------------------GQKAAAAGGKKP 796
            S            ++ +T G                           G      GGK  
Sbjct: 688 PSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSS 747

Query: 797 PRVKSRGGRGQKAAAGGKKPLRR 819
            + + R G    +++  +K  RR
Sbjct: 748 QKDRRRSGAASSSSSSREKGSRR 770


>gi|239754599 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 294

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 68/183 (37%), Positives = 86/183 (46%), Gaps = 39/183 (21%)

Query: 173 KPQKAAAAGAKS----RSGKKPRRRGAKSRGDEDKKGRQREAKSRFG------KTRGGRR 222
           +P +A AA A S    R GK+P  R + +     +   Q  +++  G      ++RGG  
Sbjct: 83  RPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGS 142

Query: 223 KKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAA 282
           +K RR K AA  AKS  GGGKKP++Q+     AA G K+   +SR GG KK RR GQ A 
Sbjct: 143 RKPRRQKAAAAQAKSLGGGGKKPRRQKC----AAAGQKAAAEESRRGGGKKPRRGGQKAV 198

Query: 283 LAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
            AGAK+   A A                          G K PRRR QKA KAA  G K 
Sbjct: 199 GAGAKKPQKAAAA-------------------------GTKTPRRRRQKAAKAAVWGQKA 233

Query: 343 GGG 345
             G
Sbjct: 234 AAG 236



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 64/176 (36%), Positives = 79/176 (44%), Gaps = 29/176 (16%)

Query: 315 NPRWGRGGKKPRRR----GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRG-KKPR 369
           +P  GR GK+P  R    G    +       R G G         +SR + R  G +KPR
Sbjct: 94  SPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGV-------CRSRPQSRGGGSRKPR 146

Query: 370 RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR 429
           RQKA+AA AKS GGG KK              PR Q      QKA A + R GG KKPRR
Sbjct: 147 RQKAAAAQAKSLGGGGKK--------------PRRQKCAAAGQKAAAEESRRGGGKKPRR 192

Query: 430 RGPK---AAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
            G K   A   +  K+ + G K PRRR QKA + A      + G+       AS +
Sbjct: 193 GGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAAGESLTPNSLASVS 248



 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 66/183 (36%), Positives = 89/183 (48%), Gaps = 33/183 (18%)

Query: 367 KPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP--RGGGS 424
           +P +  A+ AG+   G   K+        G   ++   Q+  R       ++P  RGGGS
Sbjct: 83  RPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGS 142

Query: 425 KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
           +KPRR+   AA++   KS  GGGKKPR      RQK A AG           QKA+A  +
Sbjct: 143 RKPRRQKAAAAQA---KSLGGGGKKPR------RQKCAAAG-----------QKAAAEES 182

Query: 485 KSRGGGLKSHSGKNLWRRGQKAEAAG----EKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           + RGGG K   G      GQKA  AG    +KA AAG K+  R++ +  K AV G K+  
Sbjct: 183 R-RGGGKKPRRG------GQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAA 235

Query: 541 GGS 543
           G S
Sbjct: 236 GES 238



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 82/244 (33%), Positives = 107/244 (43%), Gaps = 23/244 (9%)

Query: 67  GGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRR 126
           G  +  +RG    + G E   H    A    A N    E    +A  +   GRG      
Sbjct: 3   GPDQMEIRGGPYLLLG-EVVGHSALGAQPAQAANGDADELLELSALLQPRAGRGPCATLS 61

Query: 127 GQ---KAAATGSKKPRWRAQ------KSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
           G+    A A      R RAQ       +A AGS   G   ++  +    +S  G  P++ 
Sbjct: 62  GRCITPATALLLLSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSR---ESWTGSAPRRC 118

Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK- 236
               A SR+G    R   +SRG   +K R+++A +   K+ GG  KK RR K AA G K 
Sbjct: 119 PCQDA-SRAGSGVCRSRPQSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKA 177

Query: 237 ----SRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAA 292
               SRRGGGKKP   RR GQKA   G  +  K+   G K  RR+ Q AA A    + AA
Sbjct: 178 AAEESRRGGGKKP---RRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAA 234

Query: 293 TAGE 296
            AGE
Sbjct: 235 -AGE 237



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 69/193 (35%), Positives = 92/193 (47%), Gaps = 17/193 (8%)

Query: 5   GHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKA 64
           G   C   +GR    A    AL      L A+      +AA AG   LG   K+   +++
Sbjct: 53  GRGPCATLSGRCITPA---TALLLLSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSRES 109

Query: 65  AAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR 124
             G    R   Q  + AG    +   ++ G G  + R    QKAAAA  KSLGG G+KPR
Sbjct: 110 WTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGSRKPR---RQKAAAAQAKSLGGGGKKPR 166

Query: 125 RR-----GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQK--AAAAAGVKS--QGGEKPQ 175
           R+     GQKAAA  S+  R   +K    G K  GAGA+K   AAAAG K+  +  +K  
Sbjct: 167 RQKCAAAGQKAAAEESR--RGGGKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAA 224

Query: 176 KAAAAGAKSRSGK 188
           KAA  G K+ +G+
Sbjct: 225 KAAVWGQKAAAGE 237



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 69/173 (39%), Positives = 83/173 (47%), Gaps = 22/173 (12%)

Query: 505 KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGN 564
           +A+    +ATAA A S G  +  ++ P+    +    GS  R+     A+ A S      
Sbjct: 79  RAQCRPMQATAAEAGSPGLGRLGKEPPS----RESWTGSAPRRCPCQDASRAGSGVCRSR 134

Query: 565 KQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTK-----SRSGDGGKKAWR- 618
            QSRGGG  KPR+    AA AK+ GGG K+P  QK AA   K     SR G GGKK  R 
Sbjct: 135 PQSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRG-GGKKPRRG 193

Query: 619 -QKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAG 670
            QKA G GA   KKP    QK AAA  K   T    R    K   W + AAAG
Sbjct: 194 GQKAVGAGA---KKP----QKAAAAGTK---TPRRRRQKAAKAAVWGQKAAAG 236



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 51/108 (47%), Positives = 60/108 (55%), Gaps = 24/108 (22%)

Query: 722 KSRGGGGAKSR----GSGGAKSRGSGGAKSR------SGKKAAASKSHGGGGAKRRRGGG 771
           +SRGGG  K R     +  AKS G GG K R      +G+KAAA +S  GGG K RRGG 
Sbjct: 136 QSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRGGGKKPRRGG- 194

Query: 772 AKSRSGEKAVTAGG---QKAAAAGGKKPPRVKSRGGR----GQKAAAG 812
                 +KAV AG    QKAAAAG K P R + +  +    GQKAAAG
Sbjct: 195 ------QKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAAG 236



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 61/189 (32%), Positives = 84/189 (44%), Gaps = 25/189 (13%)

Query: 1   MDYRGHRQCN-QAAGRAGPGAPLGAALARTPVEL-----AAESAAPALSAAAAGVKIL-- 52
           + +R   QC    A  A  G+P    L + P        +A    P   A+ AG  +   
Sbjct: 74  LSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRS 133

Query: 53  -----GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG--AGGAENRGGGE 105
                G G +K RRQKAAA   K+   G      GK+ R+    AAG  A   E+R GG 
Sbjct: 134 RPQSRGGGSRKPRRQKAAAAQAKSLGGG------GKKPRRQKCAAAGQKAAAEESRRGGG 187

Query: 106 QKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAG 165
           +K    G K++G   +KP    QKAAA G+K PR R QK+A A    + A A ++     
Sbjct: 188 KKPRRGGQKAVGAGAKKP----QKAAAAGTKTPRRRRQKAAKAAVWGQKAAAGESLTPNS 243

Query: 166 VKSQGGEKP 174
           + S    +P
Sbjct: 244 LASVSFSRP 252



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 60/182 (32%), Positives = 78/182 (42%), Gaps = 22/182 (12%)

Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
           R RAQ  P              R  K   SR   + S   + P +   +A      +  +
Sbjct: 77  RLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQ 136

Query: 468 SRG--DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQ 525
           SRG   +K  RQKA+AA  KS GGG K         R QK  AAG+KA A  ++  G K+
Sbjct: 137 SRGGGSRKPRRQKAAAAQAKSLGGGGKKP-------RRQKCAAAGQKAAAEESRRGGGKK 189

Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA 585
           PRR      G K+   G+K    QKA AAG  +       + R     K   WGQ AAA 
Sbjct: 190 PRR-----GGQKAVGAGAKKP--QKAAAAGTKT------PRRRRQKAAKAAVWGQKAAAG 236

Query: 586 KT 587
           ++
Sbjct: 237 ES 238



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 57/152 (37%), Positives = 66/152 (43%), Gaps = 33/152 (21%)

Query: 691 RRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAK-------SRGSGGA-----K 738
           R RA+ R      A  G     R GK+P   +S  G   +       SR   G      +
Sbjct: 77  RLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQ 136

Query: 739 SRGSGGAKSRSGKKAAA-SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAA-----AG 792
           SRG G  K R  K AAA +KS GGGG K RR          +   A GQKAAA      G
Sbjct: 137 SRGGGSRKPRRQKAAAAQAKSLGGGGKKPRR----------QKCAAAGQKAAAEESRRGG 186

Query: 793 GKKPPR-----VKSRGGRGQKAAAGGKKPLRR 819
           GKKP R     V +   + QKAAA G K  RR
Sbjct: 187 GKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRR 218



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 55/141 (39%), Positives = 65/141 (46%), Gaps = 39/141 (27%)

Query: 477 QKASAAGT-------KSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
           Q AS AG+       +SRGGG +         R QKA AA  K+   G K     +PRRQ
Sbjct: 121 QDASRAGSGVCRSRPQSRGGGSRKP-------RRQKAAAAQAKSLGGGGK-----KPRRQ 168

Query: 530 KPAVAGAK-----SRVGGSKSRQR--QKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTA 582
           K A AG K     SR GG K  +R  QKAV AGA        +++   G   PR+  Q A
Sbjct: 169 KCAAAGQKAAAEESRRGGGKKPRRGGQKAVGAGAKK-----PQKAAAAGTKTPRRRRQKA 223

Query: 583 AAAKTRGGGDKQPGWQKAAAG 603
           A A   G        QKAAAG
Sbjct: 224 AKAAVWG--------QKAAAG 236



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 46/122 (37%), Positives = 54/122 (44%), Gaps = 39/122 (31%)

Query: 265 KSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
           +SRGGG +K RRQ   AA                 AK  GG               GGKK
Sbjct: 136 QSRGGGSRKPRRQKAAAA----------------QAKSLGG---------------GGKK 164

Query: 325 PRRRGQKAT--KAAAAGTKRGGG-----GQQKAAVVGVKSRKKQRRRG-KKPRRQKASAA 376
           PRR+   A   KAAA  ++RGGG     G QKA   G K  +K    G K PRR++  AA
Sbjct: 165 PRRQKCAAAGQKAAAEESRRGGGKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAA 224

Query: 377 GA 378
            A
Sbjct: 225 KA 226


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 81/363 (22%), Positives = 147/363 (40%), Gaps = 28/363 (7%)

Query: 204 KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRV 263
           KGR+ E    F      +R   +       G K R    K   ++RR   ++ +  +SR 
Sbjct: 137 KGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSR- 195

Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
             SR    +K R +  ++  + +K R  + +G +  +K R     +S   +        +
Sbjct: 196 --SRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKE 253

Query: 324 KPRRRGQKATKAAAAGTKRGGGGQQKAAVVGV---------KSRKKQRRRGKKPRRQKAS 374
           K R R   A K+ +    +     Q    VG          KS+ K R R ++ RR +  
Sbjct: 254 KSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQE-RRVEEE 312

Query: 375 AAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKA 434
             G+ SRG   +K LR+++ R   +        R R++    +K +  G K+ R      
Sbjct: 313 KRGSVSRGRSQEKSLRQSRSRSRSK-----GGSRSRSRSRSKSKDKRKGRKRSREESRSR 367

Query: 435 AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
           ++SR    RS      R+RG K   KA  +  + + D  + + ++ +          KS 
Sbjct: 368 SRSRSKSERS------RKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE 421

Query: 495 SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAA 554
           S +    RG+   A   + T + ++S  + +P     + + +KS    SK+R R K+ + 
Sbjct: 422 SSQR-EGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKS---ASKTRSRSKSRSR 477

Query: 555 GAT 557
            A+
Sbjct: 478 SAS 480



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 88/377 (23%), Positives = 152/377 (40%), Gaps = 52/377 (13%)

Query: 120 GRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA 179
           GRK R    K    GS++ R  ++  + + S++R   ++K+ + +G       K +  + 
Sbjct: 167 GRKIRLVEDKP---GSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSR 223

Query: 180 AGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRR 239
           +G++SRS         KSR     + R ++ KSR        ++K R    +AG ++S+ 
Sbjct: 224 SGSRSRS---------KSRSRSQSRSRSKKEKSR-----SPSKEKSRSRSHSAGKSRSK- 268

Query: 240 GGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPA 299
               K Q + +       G       SR     K R + Q       +RR      EK  
Sbjct: 269 ---SKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQ-------ERR---VEEEKRG 315

Query: 300 AKGRGGRGPKSLGGQNPR-WGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR 358
           +  RG    KSL     R   +GG + R R +  +K    G KR             +SR
Sbjct: 316 SVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRS----------REESR 365

Query: 359 KKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAK 418
            + R R K  R +K  +    S+ G  KK  +E   R   R   R  +  R   K+ +++
Sbjct: 366 SRSRSRSKSERSRKRGSK-RDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQ 424

Query: 419 PRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQK 478
             G G  +       A  ++  +SRS    K +       +  +++ +++R   K   + 
Sbjct: 425 REGRGESE------NAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS 478

Query: 479 ASAAGTKSRGGGLKSHS 495
           AS + ++SR    +SHS
Sbjct: 479 ASRSPSRSRS---RSHS 492



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 68/350 (19%), Positives = 135/350 (38%), Gaps = 44/350 (12%)

Query: 99  ENRGGGEQKAAAAGTKSLG-GRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA 157
           E++ G  ++ + + ++S    R R    R  ++ +  SK    +++  + +GS++R    
Sbjct: 174 EDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSR 233

Query: 158 QKAAAAAGVKSQGGEKPQKAAA-----AGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKS 212
            ++ + +  K +    P K  +     +  KSRS  K +        D   K + R    
Sbjct: 234 SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293

Query: 213 RFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDK 272
              K++   R + RR +    G+ SR    +K  +Q R   ++  G +SR   SR     
Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSR---SRSRSKS 350

Query: 273 KLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKA 332
           K +R+G+  +   ++ R  + +                            ++ R+RG K 
Sbjct: 351 KDKRKGRKRSREESRSRSRSRS--------------------------KSERSRKRGSKR 384

Query: 333 TKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREA 392
              A +  K+     +K      +SR   R   K+    K+ ++  + RG  +  G  + 
Sbjct: 385 DSKAGSSKKK-----KKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQE 439

Query: 393 KR---RGDGRKKPRW-QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR 438
            R   R + + KP      R R++ A   + R     +   R P  ++SR
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 68/324 (20%), Positives = 130/324 (40%), Gaps = 37/324 (11%)

Query: 324 KPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGG 383
           + R R  + +++ +  +K      +  +  G +SR K R R +   R K      KSR  
Sbjct: 195 RSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKE----KSRSP 250

Query: 384 GDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR 443
             +K    +   G  R K + Q   +        KP+   S+ P R           KS+
Sbjct: 251 SKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK---SRSPSRH----------KSK 297

Query: 444 SGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRG 503
           S    K R R Q+ R +  + G+ SRG  ++   + S + ++S+GG       ++  R  
Sbjct: 298 S----KSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGS----RSRSRSRSK 349

Query: 504 QKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAK--SRVGGSKSRQRQKAVAAGATSHGG 561
            K +  G K +   ++SR R + + ++    G+K  S+ G SK ++++    + + S   
Sbjct: 350 SKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSR 409

Query: 562 GGNKQ---------SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDG 612
             +K+          R G G            +++R     +P     +   +KS S   
Sbjct: 410 SVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTR 469

Query: 613 GKKAWRQKAAG-TGAKSRKKPWRR 635
            +   R ++A  + ++SR +   R
Sbjct: 470 SRSKSRSRSASRSPSRSRSRSHSR 493



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 89/380 (23%), Positives = 151/380 (39%), Gaps = 59/380 (15%)

Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSK----KPRRRGP 432
           G K R   DK G R  +     R   R ++  R ++K+   + R G SK    K R R  
Sbjct: 167 GRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKS---RSRSGSSKSSHSKSRSRSR 223

Query: 433 KAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLK 492
             ++SR  KSRS    + R + +K+R  +          K++ R ++ +AG KSR    K
Sbjct: 224 SGSRSRS-KSRSRSQSRSRSKKEKSRSPS----------KEKSRSRSHSAG-KSRSKS-K 270

Query: 493 SHSGKNLWRRGQ--KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQK 550
             + + +       K ++       + +KSR R Q RR +    G+ SR    +   RQ 
Sbjct: 271 DQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQS 330

Query: 551 AVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSG 610
                          +SR  GG++ R   ++ +  K +G        +K +   ++SRS 
Sbjct: 331 -------------RSRSRSKGGSRSRSRSRSKSKDKRKG--------RKRSREESRSRSR 369

Query: 611 DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAG 670
              K            +SRK+  +R  K  ++ +K       S+     +   ++   A 
Sbjct: 370 SRSKSE----------RSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAK 419

Query: 671 SESSAAAAVGQEAEA-RKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGA 729
           SESS     G+   A   +  R R++S      N      P + R +     K+R    +
Sbjct: 420 SESSQREGRGESENAGTNQETRSRSRSNSKSKPNL-----PSESRSRSKSASKTRSRSKS 474

Query: 730 KSRGSGGAKSRGSGGAKSRS 749
           +SR +  + SR    + SRS
Sbjct: 475 RSRSASRSPSRSRSRSHSRS 494



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 78/351 (22%), Positives = 152/351 (43%), Gaps = 31/351 (8%)

Query: 352 VVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRA 411
           V G K R  + + G + RR+  S + + SR     +  R+++ R  G  K      R R+
Sbjct: 165 VNGRKIRLVEDKPGSR-RRRSYSRSRSHSRSRSRSRHSRKSRSR-SGSSKSSHSKSRSRS 222

Query: 412 QKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGD 471
           +    ++       K R R    ++S+  KSRS   +K R R       A ++ ++S+  
Sbjct: 223 RSGSRSR------SKSRSRSQSRSRSKKEKSRSPSKEKSRSRS----HSAGKSRSKSKDQ 272

Query: 472 KKQGRQKASAAGTKSRGGGLKSHSGKNLWR-RGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
            ++  Q     G K +      H  K+  R R Q+     EK    G+ SRGR Q +  +
Sbjct: 273 AEEKIQNNDNVG-KPKSRSPSRHKSKSKSRSRSQERRVEEEK---RGSVSRGRSQEKSLR 328

Query: 531 PAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG 590
            + + ++S+ GGS+SR R ++ +         G K+SR    ++ R   ++  + K    
Sbjct: 329 QSRSRSRSK-GGSRSRSRSRSKSKDKRK----GRKRSREESRSRSRSRSKSERSRKRGSK 383

Query: 591 GDKQPG--WQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA 648
            D + G   +K      +S+S    +   +++       S+++   RG+ + A   +   
Sbjct: 384 RDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQRE--GRGESENAGTNQ--E 439

Query: 649 TGATSRGSGGKQPRWQKPAAAGSESSA---AAAVGQEAEARKKPRRRRAKS 696
           T + SR +   +P     + + S+S++   + +  +   A + P R R++S
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRS 490



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 70/343 (20%), Positives = 146/343 (42%), Gaps = 48/343 (13%)

Query: 57  KKLRRQKAAAGGKKARLRGQKGAVAGKEAR-QHWQKAAGAGGAENRGGGEQKAAAAGTKS 115
           +K+R  +   G ++ R   +  + +   +R +H +K+    G+      + ++ +     
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRS--- 224

Query: 116 LGGRGR-KPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGE-- 172
            G R R K R R Q  + +  +K R  +++ + + S + G    K+   A  K Q  +  
Sbjct: 225 -GSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNV 283

Query: 173 -KPQKAAAAGAKSRSGKKPR---------RRGAKSRG-DEDKKGRQREAKSRFGKTRGGR 221
            KP+  + +  KS+S  + R         +RG+ SRG  ++K  RQ  ++SR   ++GG 
Sbjct: 284 GKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSR---SKGGS 340

Query: 222 RKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR---------GGGDK 272
           R + R        ++S+    +K +K+ R   ++ +  +S+  +SR          G  K
Sbjct: 341 RSRSR--------SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSK 392

Query: 273 KLRRQGQNAALAGAKRRGAATAGE--KPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
           K +++  + + + +  R  +   E  K  +  R GRG     G N       ++ R R +
Sbjct: 393 KKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTN-------QETRSRSR 445

Query: 331 KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKA 373
             +K+            + A+    +S+ + R   + P R ++
Sbjct: 446 SNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRS 488



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 53/264 (20%), Positives = 109/264 (41%), Gaps = 20/264 (7%)

Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
           SR    ++ R   + +  +++R G  K       +   ++SRSG   +   R ++    +
Sbjct: 186 SRSRSHSRSRSRSRHSRKSRSRSGSSKS----SHSKSRSRSRSGSRSRSKSRSRSQSR-S 240

Query: 627 KSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
           +S+K+  R   K+ + +    A  + S+     + + Q     G   S + +     +++
Sbjct: 241 RSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPS---RHKSK 297

Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKS------- 739
            K R R  + R +  +  +V     Q +  +    +SR  GG++SR    +KS       
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGR 357

Query: 740 -RGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
            R    ++SRS  ++ + +S   G  +  + G +K +  E    +  +  + +  K+   
Sbjct: 358 KRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREH 417

Query: 799 VKS----RGGRGQKAAAGGKKPLR 818
            KS    R GRG+   AG  +  R
Sbjct: 418 AKSESSQREGRGESENAGTNQETR 441



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 63/334 (18%), Positives = 132/334 (39%), Gaps = 33/334 (9%)

Query: 476 RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
           R+  S + + SR      HS K+  R G    +  +  + + + SR R + R +  + + 
Sbjct: 182 RRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSR 241

Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP 595
           +K     S S+++ ++      SH  G ++        +  Q        K+R      P
Sbjct: 242 SKKEKSRSPSKEKSRS-----RSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRS-----P 291

Query: 596 GWQKAAAGVTKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRRGQKDAAAAEKAWATGATSR 654
              K+ +   KSRS    ++   +K       +S++K  R+ +             + SR
Sbjct: 292 SRHKSKS---KSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR-------------SRSR 335

Query: 655 GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRR 714
             GG + R +  + +  +        +E+ +R + R +  +SR  G +  +   +  +++
Sbjct: 336 SKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKK 395

Query: 715 GKKPRLGKSRGGGGAKSRGSGGAKSR-----GSGGAKSRSGKKAAASKSHGGGGAKRRRG 769
            +     +SR    + S+    AKS      G G +++    +   S+S     +K    
Sbjct: 396 KEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLP 455

Query: 770 GGAKSRSGEKAVTAGGQKA-AAAGGKKPPRVKSR 802
             ++SRS   + T    K+ + +  + P R +SR
Sbjct: 456 SESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 36/154 (23%), Positives = 59/154 (38%), Gaps = 21/154 (13%)

Query: 680 GQEAEARK------KP--RRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG--- 728
           G E   RK      KP  RRRR+ SR      +       + R +  R  +SR G     
Sbjct: 162 GTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRS-------RSRSRHSRKSRSRSGSSKSS 214

Query: 729 ---AKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGG 785
              ++SR   G++SR    ++S+S  ++   KS      K R    +  +S  K+     
Sbjct: 215 HSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAE 274

Query: 786 QKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
           +K         P+ +S      K+ +  +   RR
Sbjct: 275 EKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERR 308


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)

Query: 32  ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
           E   E + PA  AAA      AG     S D      +    GK +    Q  A +    
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 86  RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
               +KAA A G   + G        G      R +KP    + ++  GS+     +++ 
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282

Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
           A AG++++   ++K     AA+A  K   G+      P KA A  +++++GK      + 
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342

Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
           S    D +     AK+                +  A G  S+ G    P K+  R+G   
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388

Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
           A  GK+    ++    K  R +   ++   +     A A  KP+ K    R   +   ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446

Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
           PR G     PR+ G  A +      +       + +      +   +  + +  GK P+ 
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506

Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
           + AS  G    G    KG         G   P     +W+     + +  +    G   +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559

Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
            P    P   KS G     K  S   K P    QKA   A +  AE   D  +  +++S 
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616

Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           +A ++     + +   K   +  Q      +  T A AK     +   Q P  AG  +  
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675

Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
            GS       AVA G        +         +      T   AK+ G G +     KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726

Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
           A+   K   G G       K     T  K+ K+      ++ + +E+A A+ A  + S  
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
           K      PAAA            G   +AAA   Q + ++ KP  R  +     +RG   
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
                 AV      + G +   G S     ++      A+ + SG         A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906

Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
              G A    G  G + +++G++  +    + + + G+ P  V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 176/855 (20%), Positives = 295/855 (34%), Gaps = 115/855 (13%)

Query: 20   APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
            A + AA A+  +++    A P  +   A  K+             G+         A AG
Sbjct: 625  AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684

Query: 68   GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
            G +        +       +    A   G A++ G G Q KAA+   K   G+G  P   
Sbjct: 685  GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744

Query: 127  GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
            G+    TG    + +A+K   + S    + +++AAA+ A VK+   +   KA  A A++ 
Sbjct: 745  GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800

Query: 186  SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
            S K          G     G+   A ++       +++   + KP     ++     + P
Sbjct: 801  SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844

Query: 246  QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
                  G+  AT  +++ G     G  +     +  A           A  KP+ K    
Sbjct: 845  ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896

Query: 306  RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
            R   +   ++PR G     P + G  A +A       ++  +    G+  AAV       
Sbjct: 897  RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 354  -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
                         G  +   Q +    PR+ +AS + A+S      D+  +   +    G
Sbjct: 957  PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016

Query: 399  RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR--SGGGKKPRRRGQK 456
             +      P    + AP A   G  S K   R     K  G  ++  S  G  P    Q 
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQS 1076

Query: 457  ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
               +A     + R  K    Q+A+ A   S      S S       G+  + A    T  
Sbjct: 1077 TSVQAKGTN-KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135

Query: 517  GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
            G  +  R +   ++ A   ++  V           +  G T      +K +         
Sbjct: 1136 GP-TPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP-------- 1186

Query: 577  QWGQTAAAAKTRGGGDKQPGWQKA----AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKP 632
            +   + + + T    D   G Q+A    AAG+   ++G  GK+A    A+GT  +  +KP
Sbjct: 1187 KLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG--GKEA----ASGTTPQKSRKP 1240

Query: 633  WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-------- 684
             ++G  +  A+  A  +  T    G   P  +    A         + QE +        
Sbjct: 1241 -KKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1299

Query: 685  -ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
             +RK    R+ K  GD  Q AA       R  KK +LG   GG  + S       S+G  
Sbjct: 1300 SSRKGWESRKRKLSGD--QPAA----RTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA 1353

Query: 744  GAKSRSG--KKAAASKSHGGGGAK------RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
                 SG  K+     S G  GAK       ++G G      +    +  +K  +   KK
Sbjct: 1354 KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1413

Query: 796  PPRVKSRGGRGQKAA 810
                K +  + +KA+
Sbjct: 1414 DKEKKEKKKKAKKAS 1428



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 20/242 (8%)

Query: 32   ELAAESAAPALSAAAAGVKIL-GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQ 90
            E   + AA  LS    G +   G+  +K R+ K  AG  +A     +  +      Q W 
Sbjct: 1209 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWP 1268

Query: 91   ------KAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
                  +A+           E+K     TK    +G + R+R        ++ PR + +K
Sbjct: 1269 LNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1328

Query: 145  SAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKK 204
               AG    G  A  +       S+G  K  KA+    + +       +GAK   +E+ +
Sbjct: 1329 KLGAGE---GGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1385

Query: 205  --------GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK--SRRGGGKKPQKQRRRGQK 254
                    G Q   KS+  K +  +RKK +  K     AK  S +      QK++++ +K
Sbjct: 1386 KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1445

Query: 255  AA 256
             A
Sbjct: 1446 TA 1447



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 102/454 (22%), Positives = 164/454 (36%), Gaps = 70/454 (15%)

Query: 34   AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
            +A    PA S  +  V+    G  KLR+ K            Q+   A + +      + 
Sbjct: 1064 SAVGTLPATSPQSTSVQ--AKGTNKLRKPKLP--------EVQQATKAPESSDDSEDSSD 1113

Query: 94   GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
             + G+E  G G Q A +A T  +G    +     ++ AA  S+       +S  +G    
Sbjct: 1114 SSSGSEEDGEGPQGAKSAHTL-VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1172

Query: 154  G---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
            G   A +Q + A   + S     P  ++   AK     K   +  ++ G    K   +EA
Sbjct: 1173 GLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1228

Query: 211  KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
             S      G   +K R+PK  AG  ++     +    Q   GQ      +++V  S    
Sbjct: 1229 AS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EAQVQASVVKV 1281

Query: 271  DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
              +L  Q         +R+      ++ + KG   R  K L G  P      + PR + +
Sbjct: 1282 LTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----AARTPRSKKK 1327

Query: 331  KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLR 390
            K   A       G GG+       V   K       K +R KAS         GD K   
Sbjct: 1328 KKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS---------GDVK--- 1363

Query: 391  EAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKP 450
            E K +G    +     P    QK       G  S       PK+ K +    +    K+ 
Sbjct: 1364 EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKSDKRKKDKEK 1417

Query: 451  RRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
            + + +KA+ KA+   +ES   KK+ ++K +A  T
Sbjct: 1418 KEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1450


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)

Query: 32  ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
           E   E + PA  AAA      AG     S D      +    GK +    Q  A +    
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 86  RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
               +KAA A G   + G        G      R +KP    + ++  GS+     +++ 
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282

Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
           A AG++++   ++K     AA+A  K   G+      P KA A  +++++GK      + 
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342

Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
           S    D +     AK+                +  A G  S+ G    P K+  R+G   
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388

Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
           A  GK+    ++    K  R +   ++   +     A A  KP+ K    R   +   ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446

Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
           PR G     PR+ G  A +      +       + +      +   +  + +  GK P+ 
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506

Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
           + AS  G    G    KG         G   P     +W+     + +  +    G   +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559

Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
            P    P   KS G     K  S   K P    QKA   A +  AE   D  +  +++S 
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616

Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           +A ++     + +   K   +  Q      +  T A AK     +   Q P  AG  +  
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675

Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
            GS       AVA G        +         +      T   AK+ G G +     KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726

Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
           A+   K   G G       K     T  K+ K+      ++ + +E+A A+ A  + S  
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
           K      PAAA            G   +AAA   Q + ++ KP  R  +     +RG   
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
                 AV      + G +   G S     ++      A+ + SG         A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906

Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
              G A    G  G + +++G++  +    + + + G+ P  V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 182/882 (20%), Positives = 300/882 (34%), Gaps = 132/882 (14%)

Query: 20   APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
            A + AA A+  +++    A P  +   A  K+             G+         A AG
Sbjct: 625  AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684

Query: 68   GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
            G +        +       +    A   G A++ G G Q KAA+   K   G+G  P   
Sbjct: 685  GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744

Query: 127  GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
            G+    TG    + +A+K   + S    + +++AAA+ A VK+   +   KA  A A++ 
Sbjct: 745  GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800

Query: 186  SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
            S K          G     G+   A ++       +++   + KP     ++     + P
Sbjct: 801  SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844

Query: 246  QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
                  G+  AT  +++ G     G  +     +  A           A  KP+ K    
Sbjct: 845  ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896

Query: 306  RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
            R   +   ++PR G     P + G  A +A       ++  +    G+  AAV       
Sbjct: 897  RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 354  -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
                         G  +   Q +    PR+ +AS + A+S      D+  +   +    G
Sbjct: 957  PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016

Query: 399  RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR------------SGG 446
             +      P    + AP A   G  S K   R     K  G  ++               
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAA 1076

Query: 447  GKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKA 506
             K   ++  +A+   A     S  D   G   A++  + S      +   K      Q+A
Sbjct: 1077 LKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1136

Query: 507  EAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSR--VGGSKSRQRQ--KAVAAGATSHGGG 562
              A E +  +   S              GAKS   +G + SR     +  AA ++     
Sbjct: 1137 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVV 1196

Query: 563  GNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP-------------GWQKA----AAGVT 605
               QS   G   P      + A+K     D  P             G Q+A    AAG+ 
Sbjct: 1197 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1256

Query: 606  KSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQK 665
              ++G  GK+A    A+GT  +  +KP ++G  +  A+  A  +  T    G   P  + 
Sbjct: 1257 SPKTG--GKEA----ASGTTPQKSRKP-KKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1309

Query: 666  PAAAGSESSAAAAVGQEAE---------ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGK 716
               A         + QE +         +RK    R+ K  GD  Q AA       R  K
Sbjct: 1310 QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGD--QPAA----RTPRSKK 1363

Query: 717  KPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSG--KKAAASKSHGGGGAK------RRR 768
            K +LG   GG  + S       S+G       SG  K+     S G  GAK       ++
Sbjct: 1364 KKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQK 1423

Query: 769  GGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAA 810
            G G      +    +  +K  +   KK    K +  + +KA+
Sbjct: 1424 GMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1465



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 105/463 (22%), Positives = 167/463 (36%), Gaps = 70/463 (15%)

Query: 26   LARTPVELAAESAAPALSAAAA-GVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKE 84
            +ART      +SA   L A +     +   G  KLR+ K            Q+   A + 
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--------EVQQATKAPES 1142

Query: 85   ARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
            +      +  + G+E  G G Q A +A T  LG    +     ++ AA  S+       +
Sbjct: 1143 SDDSEDSSDSSSGSEEDGEGPQGAKSAHT--LGPTPSRTETLVEETAAESSEDDVVAPSQ 1200

Query: 145  SAAAGSKNRG---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDE 201
            S  +G    G   A +Q + A   + S     P  ++   AK     K   +  ++ G  
Sbjct: 1201 SLLSGYMTPGLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGML 1256

Query: 202  DKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS 261
              K   +EA S      G   +K R+PK  AG  ++     +    Q   GQ      ++
Sbjct: 1257 SPKTGGKEAAS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EA 1309

Query: 262  RVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRG 321
            +V  S      +L  Q         +R+      ++ + KG   R  K L G  P     
Sbjct: 1310 QVQASVVKVLTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----A 1355

Query: 322  GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSR 381
             + PR + +K   A       G GG+       V   K       K +R KAS       
Sbjct: 1356 ARTPRSKKKKKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS------- 1396

Query: 382  GGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGK 441
              GD K   E K +G    +     P    QK       G  S       PK+ K +   
Sbjct: 1397 --GDVK---EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKS 1445

Query: 442  SRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
             +    K+ + + +KA+ KA+   +ES   KK+ ++K +A  T
Sbjct: 1446 DKRKKDKEKKEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1487


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)

Query: 32  ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
           E   E + PA  AAA      AG     S D      +    GK +    Q  A +    
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 86  RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
               +KAA A G   + G        G      R +KP    + ++  GS+     +++ 
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282

Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
           A AG++++   ++K     AA+A  K   G+      P KA A  +++++GK      + 
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342

Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
           S    D +     AK+                +  A G  S+ G    P K+  R+G   
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388

Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
           A  GK+    ++    K  R +   ++   +     A A  KP+ K    R   +   ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446

Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
           PR G     PR+ G  A +      +       + +      +   +  + +  GK P+ 
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506

Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
           + AS  G    G    KG         G   P     +W+     + +  +    G   +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559

Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
            P    P   KS G     K  S   K P    QKA   A +  AE   D  +  +++S 
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616

Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           +A ++     + +   K   +  Q      +  T A AK     +   Q P  AG  +  
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675

Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
            GS       AVA G        +         +      T   AK+ G G +     KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726

Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
           A+   K   G G       K     T  K+ K+      ++ + +E+A A+ A  + S  
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
           K      PAAA            G   +AAA   Q + ++ KP  R  +     +RG   
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
                 AV      + G +   G S     ++      A+ + SG         A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906

Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
              G A    G  G + +++G++  +    + + + G+ P  V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 176/855 (20%), Positives = 294/855 (34%), Gaps = 116/855 (13%)

Query: 20   APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
            A + AA A+  +++    A P  +   A  K+             G+         A AG
Sbjct: 625  AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684

Query: 68   GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
            G +        +       +    A   G A++ G G Q KAA+   K   G+G  P   
Sbjct: 685  GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744

Query: 127  GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
            G+    TG    + +A+K   + S    + +++AAA+ A VK+   +   KA  A A++ 
Sbjct: 745  GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800

Query: 186  SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
            S K          G     G+   A ++       +++   + KP     ++     + P
Sbjct: 801  SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844

Query: 246  QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
                  G+  AT  +++ G     G  +     +  A           A  KP+ K    
Sbjct: 845  ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896

Query: 306  RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
            R   +   ++PR G     P + G  A +A       ++  +    G+  AAV       
Sbjct: 897  RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 354  -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
                         G  +   Q +    PR+ +AS + A+S      D+  +   +    G
Sbjct: 957  PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016

Query: 399  RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR--SGGGKKPRRRGQK 456
             +      P    + AP A   G  S K   R     K  G  ++  S  G  P    Q 
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQS 1076

Query: 457  ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
               +A     + R  K    Q+A+ A   S      S S       G+  + A    T  
Sbjct: 1077 TSVQAKGTN-KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1135

Query: 517  GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
               SR   +   ++ A   ++  V           +  G T      +K +         
Sbjct: 1136 PTPSR--TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP-------- 1185

Query: 577  QWGQTAAAAKTRGGGDKQPGWQKA----AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKP 632
            +   + + + T    D   G Q+A    AAG+   ++G  GK+A    A+GT  +  +KP
Sbjct: 1186 KLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG--GKEA----ASGTTPQKSRKP 1239

Query: 633  WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-------- 684
             ++G  +  A+  A  +  T    G   P  +    A         + QE +        
Sbjct: 1240 -KKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1298

Query: 685  -ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
             +RK    R+ K  GD  Q AA       R  KK +LG   GG  + S       S+G  
Sbjct: 1299 SSRKGWESRKRKLSGD--QPAA----RTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA 1352

Query: 744  GAKSRSG--KKAAASKSHGGGGAK------RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
                 SG  K+     S G  GAK       ++G G      +    +  +K  +   KK
Sbjct: 1353 KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1412

Query: 796  PPRVKSRGGRGQKAA 810
                K +  + +KA+
Sbjct: 1413 DKEKKEKKKKAKKAS 1427



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 20/242 (8%)

Query: 32   ELAAESAAPALSAAAAGVKIL-GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQ 90
            E   + AA  LS    G +   G+  +K R+ K  AG  +A     +  +      Q W 
Sbjct: 1208 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWP 1267

Query: 91   ------KAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
                  +A+           E+K     TK    +G + R+R        ++ PR + +K
Sbjct: 1268 LNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1327

Query: 145  SAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKK 204
               AG    G  A  +       S+G  K  KA+    + +       +GAK   +E+ +
Sbjct: 1328 KLGAGE---GGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1384

Query: 205  --------GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK--SRRGGGKKPQKQRRRGQK 254
                    G Q   KS+  K +  +RKK +  K     AK  S +      QK++++ +K
Sbjct: 1385 KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1444

Query: 255  AA 256
             A
Sbjct: 1445 TA 1446



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 103/454 (22%), Positives = 164/454 (36%), Gaps = 71/454 (15%)

Query: 34   AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
            +A    PA S  +  V+    G  KLR+ K            Q+   A + +      + 
Sbjct: 1064 SAVGTLPATSPQSTSVQ--AKGTNKLRKPKLP--------EVQQATKAPESSDDSEDSSD 1113

Query: 94   GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
             + G+E  G G Q A +A T  LG    +     ++ AA  S+       +S  +G    
Sbjct: 1114 SSSGSEEDGEGPQGAKSAHT--LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1171

Query: 154  G---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
            G   A +Q + A   + S     P  ++   AK     K   +  ++ G    K   +EA
Sbjct: 1172 GLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1227

Query: 211  KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
             S      G   +K R+PK  AG  ++     +    Q   GQ      +++V  S    
Sbjct: 1228 AS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EAQVQASVVKV 1280

Query: 271  DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
              +L  Q         +R+      ++ + KG   R  K L G  P      + PR + +
Sbjct: 1281 LTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----AARTPRSKKK 1326

Query: 331  KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLR 390
            K   A       G GG+       V   K       K +R KAS         GD K   
Sbjct: 1327 KKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS---------GDVK--- 1362

Query: 391  EAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKP 450
            E K +G    +     P    QK       G  S       PK+ K +    +    K+ 
Sbjct: 1363 EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKSDKRKKDKEK 1416

Query: 451  RRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
            + + +KA+ KA+   +ES   KK+ ++K +A  T
Sbjct: 1417 KEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1449


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)

Query: 32  ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
           E   E + PA  AAA      AG     S D      +    GK +    Q  A +    
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 86  RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
               +KAA A G   + G        G      R +KP    + ++  GS+     +++ 
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282

Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
           A AG++++   ++K     AA+A  K   G+      P KA A  +++++GK      + 
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342

Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
           S    D +     AK+                +  A G  S+ G    P K+  R+G   
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388

Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
           A  GK+    ++    K  R +   ++   +     A A  KP+ K    R   +   ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446

Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
           PR G     PR+ G  A +      +       + +      +   +  + +  GK P+ 
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506

Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
           + AS  G    G    KG         G   P     +W+     + +  +    G   +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559

Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
            P    P   KS G     K  S   K P    QKA   A +  AE   D  +  +++S 
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616

Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
           +A ++     + +   K   +  Q      +  T A AK     +   Q P  AG  +  
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675

Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
            GS       AVA G        +         +      T   AK+ G G +     KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726

Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
           A+   K   G G       K     T  K+ K+      ++ + +E+A A+ A  + S  
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
           K      PAAA            G   +AAA   Q + ++ KP  R  +     +RG   
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846

Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
                 AV      + G +   G S     ++      A+ + SG         A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906

Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
              G A    G  G + +++G++  +    + + + G+ P  V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 124/565 (21%), Positives = 204/565 (36%), Gaps = 90/565 (15%)

Query: 34  AAESAAPALSAAAAGVKILGSGD----KKLRRQKAAAGGKKARLRGQKGAVAGKEARQH- 88
           A  +AA A +AAAA       G     K+L R K  AGG++ R RG +   AG+EA +  
Sbjct: 63  APGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPR---AGQEAEKRR 119

Query: 89  -----WQKAAGAGGAENRGG--------------------GEQKAAAAGTKS--LGGRGR 121
                  +  G GGA + GG                    G   AA A T +   GG G 
Sbjct: 120 VFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGG 179

Query: 122 KP-RRRGQKAAATGSKKPRWRAQKSAAAGSKNR---------GAGAQKAAAAAGVKSQGG 171
            P    G +    GS++   R ++S++  SK R           G  +A+ +    S  G
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239

Query: 172 EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
           E+  + A +G+ S SG   RR+ A +        + R++K+   +T+  +       +P 
Sbjct: 240 EERAEVAKSGSSSSSG--GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEP- 296

Query: 232 AGGAKSRRGGGKKPQKQRRRGQKAATGGK---------SRVGKSR------GGGDKKLRR 276
               K+ R    +P+  RRR   +  GG+         S+  +SR      GGG     R
Sbjct: 297 ---PKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353

Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
           +   +    ++RR  + +      +G G   P      + R  R    P  R    +++ 
Sbjct: 354 RLPRSPSPYSRRRSPSYSRHSSYERG-GDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412

Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
           +  + R    + +  +    SR + R     P      ++ A       K    EA R  
Sbjct: 413 SPYSSRHSRSRSRHRL----SRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAA 468

Query: 397 DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
           +             A KA  A      + K  +    +  ++G    S    +       
Sbjct: 469 E-------------AAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDV 515

Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
            + K   A + S G    G  K   A TK      K  +   + +  +KA   G+++ +A
Sbjct: 516 KKIKIEHAPSPSSG----GTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSA 571

Query: 517 GAKSRGRKQPRRQKPAV--AGAKSR 539
             K        + KP     GAK +
Sbjct: 572 ATKEESVSLKEKTKPLTPSIGAKEK 596



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 100/483 (20%), Positives = 169/483 (34%), Gaps = 66/483 (13%)

Query: 105 EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSA--AAGSKNRGAGAQKAAA 162
           E K  A G +  GGR +  RRRG +A     K+  +   +      G  + G G      
Sbjct: 88  EVKRLARGKRRAGGRQK--RRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145

Query: 163 AAGVKSQ--------GGEKPQKAAAAGAKSRSGKKP-RRRGAKSRGDEDKKGRQREAKSR 213
              V SQ        G      A AAG    SG  P    G + RG+  ++  +R+ +S 
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205

Query: 214 FGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKK 273
            G+++  R ++HRR     GG+++ +   +       R + A +G  S  G         
Sbjct: 206 SGRSK-ERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSG--------- 255

Query: 274 LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
                      G ++  +AT+    + K R  +  +S    +       K+P +  ++  
Sbjct: 256 -----------GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK 304

Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
               A  +R     +  + +G +       R  +  R + S + A   GGG     R   
Sbjct: 305 TEPKAYRRR-----RSLSPLGGRDDSPVSHRASQSLRSRKSPSPA---GGGSSPYSRRLP 356

Query: 394 RRG---DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGP-KAAKSRGGKSRSGGGKK 449
           R       R+ P +       +    +      S   R R P      R GKSRS     
Sbjct: 357 RSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYS 416

Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA 509
            R    ++R + +         + + R  + +  T +    L +   KN   R  +A  A
Sbjct: 417 SRHSRSRSRHRLS---------RSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARA 467

Query: 510 GEKATAA-----------GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS 558
            E A AA            AK+     P +     + + S+    K  ++ K   A + S
Sbjct: 468 AEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPS 527

Query: 559 HGG 561
            GG
Sbjct: 528 SGG 530



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 106/475 (22%), Positives = 169/475 (35%), Gaps = 76/475 (16%)

Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
           GK R GG +K RR+G  A     KRR  +     P  +  GG G  S GG  P       
Sbjct: 95  GKRRAGGRQK-RRRGPRAGQEAEKRRVFSL----PQPQQDGGGGASSGGGVTPLVEYEDV 149

Query: 324 KPRRR-------GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
             +            AT A AAG   G GG                          AS++
Sbjct: 150 SSQSEQGLLLGGASAATAATAAGGTGGSGGSP------------------------ASSS 185

Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAK 436
           G + RG G ++  R  +R   GR K R +  RRR  +   ++     S+       +A  
Sbjct: 186 GTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEV 245

Query: 437 SRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH-- 494
           ++ G S S GG          R+K+A A + S   +K    KA  + TKS      ++  
Sbjct: 246 AKSGSSSSSGG----------RRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295

Query: 495 ---------SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS------- 538
                    +    +RR +     G +  +  +    +    R+ P+ AG  S       
Sbjct: 296 PPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRL 355

Query: 539 -RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG------QTAAAAKTRGGG 591
            R     SR+R  + +  ++   GG    S     +  R         + +  +++R   
Sbjct: 356 PRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPY 415

Query: 592 DKQPGWQKAAAGVTKSRSGDGG-KKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
             +    ++   +++SRS       +     +   A+  K    R  + A AAE A A  
Sbjct: 416 SSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAE 475

Query: 651 AT----SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
           AT    +     K      P    +E+SA+A+     +  KK +   A S   GG
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGG 530



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 30/219 (13%)

Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQR---------QKAVAAGATS 558
           AA   A AA + S     P  +   +A  K R GG + R+R         ++ V +    
Sbjct: 67  AAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQP 126

Query: 559 HGGGGNKQSRGGGGNKPRQW--------------GQTAAAAKTRGGGDKQPGWQKAAAGV 604
              GG   S GGG     ++              G +AA A T  GG    G   A++  
Sbjct: 127 QQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSG 186

Query: 605 TKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQP 661
           T+ R     ++  R + + +G +K R +  RR  GQ+  + A K+ +  + S     +  
Sbjct: 187 TQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVA 246

Query: 662 RWQKPAAAGSESSAAAAVGQEAEARK----KPRRRRAKS 696
           +    +++G    +A+A    + +RK    K  R R KS
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKS 285



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/186 (25%), Positives = 74/186 (39%), Gaps = 47/186 (25%)

Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP--- 710
           R +GG+Q R + P A           GQEAE R+     + +  G GG ++  G+ P   
Sbjct: 97  RRAGGRQKRRRGPRA-----------GQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145

Query: 711 WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA----------------------KSR 748
           ++    +   G   GG  A +  +    + GSGG+                      +S 
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205

Query: 749 SGKKAAASKSHGGGGAKRR---RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
           SG+     + H     +RR   RGG   S+S  +   +G ++A  A   K     S GGR
Sbjct: 206 SGRSKERHREH-----RRRDGQRGGSEASKSRSRHSHSGEERAEVA---KSGSSSSSGGR 257

Query: 806 GQKAAA 811
            + A+A
Sbjct: 258 RKSASA 263



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 50/223 (22%), Positives = 80/223 (35%), Gaps = 29/223 (13%)

Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA--------TGA 651
           AAA  + S    G     ++ A G      ++  RRG +    AEK            G 
Sbjct: 72  AAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGG 131

Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
               SGG      +     S+S     +G  + A          + G GG  A+   +  
Sbjct: 132 GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAA--GGTGGSGGSPASS--SGT 187

Query: 712 QRRG----KKPRLGKSRGGGGAKSR---------GSGGAKSRGSGGAKSRSGKK----AA 754
           QRRG    ++PR  +    G +K R           GG+++  S    S SG++    A 
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 755 ASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
           +  S   GG ++     + S S  K   +   ++     K+PP
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPP 290


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 124/565 (21%), Positives = 204/565 (36%), Gaps = 90/565 (15%)

Query: 34  AAESAAPALSAAAAGVKILGSGD----KKLRRQKAAAGGKKARLRGQKGAVAGKEARQH- 88
           A  +AA A +AAAA       G     K+L R K  AGG++ R RG +   AG+EA +  
Sbjct: 63  APGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPR---AGQEAEKRR 119

Query: 89  -----WQKAAGAGGAENRGG--------------------GEQKAAAAGTKS--LGGRGR 121
                  +  G GGA + GG                    G   AA A T +   GG G 
Sbjct: 120 VFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGG 179

Query: 122 KP-RRRGQKAAATGSKKPRWRAQKSAAAGSKNR---------GAGAQKAAAAAGVKSQGG 171
            P    G +    GS++   R ++S++  SK R           G  +A+ +    S  G
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239

Query: 172 EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
           E+  + A +G+ S SG   RR+ A +        + R++K+   +T+  +       +P 
Sbjct: 240 EERAEVAKSGSSSSSG--GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEP- 296

Query: 232 AGGAKSRRGGGKKPQKQRRRGQKAATGGK---------SRVGKSR------GGGDKKLRR 276
               K+ R    +P+  RRR   +  GG+         S+  +SR      GGG     R
Sbjct: 297 ---PKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353

Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
           +   +    ++RR  + +      +G G   P      + R  R    P  R    +++ 
Sbjct: 354 RLPRSPSPYSRRRSPSYSRHSSYERG-GDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412

Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
           +  + R    + +  +    SR + R     P      ++ A       K    EA R  
Sbjct: 413 SPYSSRHSRSRSRHRL----SRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAA 468

Query: 397 DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
           +             A KA  A      + K  +    +  ++G    S    +       
Sbjct: 469 E-------------AAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDV 515

Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
            + K   A + S G    G  K   A TK      K  +   + +  +KA   G+++ +A
Sbjct: 516 KKIKIEHAPSPSSG----GTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSA 571

Query: 517 GAKSRGRKQPRRQKPAV--AGAKSR 539
             K        + KP     GAK +
Sbjct: 572 ATKEESVSLKEKTKPLTPSIGAKEK 596



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 100/483 (20%), Positives = 169/483 (34%), Gaps = 66/483 (13%)

Query: 105 EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSA--AAGSKNRGAGAQKAAA 162
           E K  A G +  GGR +  RRRG +A     K+  +   +      G  + G G      
Sbjct: 88  EVKRLARGKRRAGGRQK--RRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145

Query: 163 AAGVKSQ--------GGEKPQKAAAAGAKSRSGKKP-RRRGAKSRGDEDKKGRQREAKSR 213
              V SQ        G      A AAG    SG  P    G + RG+  ++  +R+ +S 
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205

Query: 214 FGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKK 273
            G+++  R ++HRR     GG+++ +   +       R + A +G  S  G         
Sbjct: 206 SGRSK-ERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSG--------- 255

Query: 274 LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
                      G ++  +AT+    + K R  +  +S    +       K+P +  ++  
Sbjct: 256 -----------GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK 304

Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
               A  +R     +  + +G +       R  +  R + S + A   GGG     R   
Sbjct: 305 TEPKAYRRR-----RSLSPLGGRDDSPVSHRASQSLRSRKSPSPA---GGGSSPYSRRLP 356

Query: 394 RRG---DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGP-KAAKSRGGKSRSGGGKK 449
           R       R+ P +       +    +      S   R R P      R GKSRS     
Sbjct: 357 RSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYS 416

Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA 509
            R    ++R + +         + + R  + +  T +    L +   KN   R  +A  A
Sbjct: 417 SRHSRSRSRHRLS---------RSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARA 467

Query: 510 GEKATAA-----------GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS 558
            E A AA            AK+     P +     + + S+    K  ++ K   A + S
Sbjct: 468 AEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPS 527

Query: 559 HGG 561
            GG
Sbjct: 528 SGG 530



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 106/475 (22%), Positives = 169/475 (35%), Gaps = 76/475 (16%)

Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
           GK R GG +K RR+G  A     KRR  +     P  +  GG G  S GG  P       
Sbjct: 95  GKRRAGGRQK-RRRGPRAGQEAEKRRVFSL----PQPQQDGGGGASSGGGVTPLVEYEDV 149

Query: 324 KPRRR-------GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
             +            AT A AAG   G GG                          AS++
Sbjct: 150 SSQSEQGLLLGGASAATAATAAGGTGGSGGSP------------------------ASSS 185

Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAK 436
           G + RG G ++  R  +R   GR K R +  RRR  +   ++     S+       +A  
Sbjct: 186 GTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEV 245

Query: 437 SRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH-- 494
           ++ G S S GG          R+K+A A + S   +K    KA  + TKS      ++  
Sbjct: 246 AKSGSSSSSGG----------RRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295

Query: 495 ---------SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS------- 538
                    +    +RR +     G +  +  +    +    R+ P+ AG  S       
Sbjct: 296 PPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRL 355

Query: 539 -RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG------QTAAAAKTRGGG 591
            R     SR+R  + +  ++   GG    S     +  R         + +  +++R   
Sbjct: 356 PRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPY 415

Query: 592 DKQPGWQKAAAGVTKSRSGDGG-KKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
             +    ++   +++SRS       +     +   A+  K    R  + A AAE A A  
Sbjct: 416 SSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAE 475

Query: 651 AT----SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
           AT    +     K      P    +E+SA+A+     +  KK +   A S   GG
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGG 530



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 30/219 (13%)

Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQR---------QKAVAAGATS 558
           AA   A AA + S     P  +   +A  K R GG + R+R         ++ V +    
Sbjct: 67  AAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQP 126

Query: 559 HGGGGNKQSRGGGGNKPRQW--------------GQTAAAAKTRGGGDKQPGWQKAAAGV 604
              GG   S GGG     ++              G +AA A T  GG    G   A++  
Sbjct: 127 QQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSG 186

Query: 605 TKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQP 661
           T+ R     ++  R + + +G +K R +  RR  GQ+  + A K+ +  + S     +  
Sbjct: 187 TQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVA 246

Query: 662 RWQKPAAAGSESSAAAAVGQEAEARK----KPRRRRAKS 696
           +    +++G    +A+A    + +RK    K  R R KS
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKS 285



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/186 (25%), Positives = 74/186 (39%), Gaps = 47/186 (25%)

Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP--- 710
           R +GG+Q R + P A           GQEAE R+     + +  G GG ++  G+ P   
Sbjct: 97  RRAGGRQKRRRGPRA-----------GQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145

Query: 711 WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA----------------------KSR 748
           ++    +   G   GG  A +  +    + GSGG+                      +S 
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205

Query: 749 SGKKAAASKSHGGGGAKRR---RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
           SG+     + H     +RR   RGG   S+S  +   +G ++A  A   K     S GGR
Sbjct: 206 SGRSKERHREH-----RRRDGQRGGSEASKSRSRHSHSGEERAEVA---KSGSSSSSGGR 257

Query: 806 GQKAAA 811
            + A+A
Sbjct: 258 RKSASA 263



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 50/223 (22%), Positives = 80/223 (35%), Gaps = 29/223 (13%)

Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA--------TGA 651
           AAA  + S    G     ++ A G      ++  RRG +    AEK            G 
Sbjct: 72  AAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGG 131

Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
               SGG      +     S+S     +G  + A          + G GG  A+   +  
Sbjct: 132 GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAA--GGTGGSGGSPASS--SGT 187

Query: 712 QRRG----KKPRLGKSRGGGGAKSR---------GSGGAKSRGSGGAKSRSGKK----AA 754
           QRRG    ++PR  +    G +K R           GG+++  S    S SG++    A 
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 755 ASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
           +  S   GG ++     + S S  K   +   ++     K+PP
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPP 290


>gi|62122917 filaggrin family member 2 [Homo sapiens]
          Length = 2391

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 157/757 (20%), Positives = 263/757 (34%), Gaps = 103/757 (13%)

Query: 94   GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAA---ATGSKKPRWRAQKSA--AA 148
            G+G  ++ G G+     +G+    G G+   R GQ +    ++GS +     Q  +   +
Sbjct: 584  GSGSGQSSGFGQH---GSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTS 640

Query: 149  GSKNRGAGAQKAAAAAGVKSQGGEKP---QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKG 205
            G    G+G+ ++       S  G+     Q  + +G  S  G+   R G  S G      
Sbjct: 641  GFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGS 700

Query: 206  RQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGK 265
             Q     + G + G            +G  +     G+        GQ  +  G+S    
Sbjct: 701  SQSSGYGQHGSSSG----------QTSGFGQHELSSGQSSSF----GQHGSGSGQSSGFG 746

Query: 266  SRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKP 325
              G G  +    GQ+ + +G    G  ++G   ++ G G  G +   G     G G  + 
Sbjct: 747  QHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSS-GYGQHGSRQTSGFGQH-GSGSSQS 804

Query: 326  RRRGQKATKAA-AAGTKRGGGGQQKAAVVGV-KSRKKQRRRGKKPRRQKASAAGAKSRGG 383
               GQ  + +  +AG  + G G  +++  G  +SR  Q   G+         +G+    G
Sbjct: 805  TGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQH-------GSGSSQSSG 857

Query: 384  GDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR 443
              + G    +  G G+        R  + +       G GS +    G       G    
Sbjct: 858  YGQHGSSSGQTSGFGQH-------RSSSGQYSGFGQHGSGSGQSSGFGQHGT---GSGQY 907

Query: 444  SGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRG 503
            SG G+   R  Q +  +     ++S G  + G       G      G    SG      G
Sbjct: 908  SGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGF-----G 962

Query: 504  QKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGG 563
            Q    +G+ +               Q  + +G  S  G  +SR  Q    +    HG G 
Sbjct: 963  QHGSGSGQSSGFG------------QHESGSGKSSGFGQHESRSSQ----SNYGQHGSGS 1006

Query: 564  NKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAG 623
            ++ S  G G      GQT    + R    +  G+ +  +G  +S SG G       +++G
Sbjct: 1007 SQSS--GYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQS-SGFGQHGTGSGQSSG 1063

Query: 624  TGA-KSRKKPWRRGQKDAAAAEKA-----WATGATSRGSGGKQPRWQKPAA---AGSESS 674
             G  +SR +    GQ  + +++ +      +    + G G  +P   + +     GS S 
Sbjct: 1064 FGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSG 1123

Query: 675  AAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGG-GAKSRG 733
             ++  GQ             KS G        G + + + G     G S+  G G    G
Sbjct: 1124 QSSGFGQHGSG-------TGKSSGFAQHEYRSGQSSYGQHG----TGSSQSSGCGQHESG 1172

Query: 734  SGGAKSRG-----------SGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVT 782
            SG   S G           SG   S SG+     +   G G     G G +S+  E   T
Sbjct: 1173 SGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQG-ESQQVESGST 1231

Query: 783  AGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
              G++    G        S+ G+GQ    G +   RR
Sbjct: 1232 VHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRR 1268



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 170/830 (20%), Positives = 284/830 (34%), Gaps = 145/830 (17%)

Query: 50  KILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG-------AGGAENRG 102
           K+  + +K L ++   A G K   RG +      E  +  +   G       +  +E   
Sbjct: 80  KLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSWSEGEE 139

Query: 103 GGEQKAAAAGTKSL--GGRGRKPRRRGQKAAATGSKKPRWRAQKSAA----AGSKNRGAG 156
            G     + GT     G   R+  R+G  +++   +  + R  +S+     +G K+R   
Sbjct: 140 HGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGS 199

Query: 157 AQKAAAAAGVKS------QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
           +         KS      + GE+ +  + + +  R G      G ++ G E    + R  
Sbjct: 200 SSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSRIR 259

Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
           + + G +  G     RR    A G  +  G G+ PQ      Q    GG+         G
Sbjct: 260 EQKLGSSCSGSGDSGRRSH--ACGYSNSSGCGR-PQNASSSCQSHRFGGQGNQFSYIQSG 316

Query: 271 DKKLRRQGQ-NAALAGAKRRGAATAGEKPAAKGRGGRG--------PKSLGGQNPRWGRG 321
            +   + GQ +  ++G +  G       P ++    RG        P++ GGQ   W  G
Sbjct: 317 CQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQ---WRTG 373

Query: 322 GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSR 381
             +    GQ            G GG Q  +         Q   G   R   +S++   S+
Sbjct: 374 SSQSSCCGQY-----------GSGGSQSCS-------NGQHEYGSCGRFSNSSSSNEFSK 415

Query: 382 GGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGK 441
                       + G G  +                      S    + G   ++S G +
Sbjct: 416 ----------CDQYGSGSSQ----------------------STSFEQHGTGLSQSSGFE 443

Query: 442 SRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWR 501
               G       GQ   Q  + + ++S G  + G      +G    G G    SG     
Sbjct: 444 QHVCGS------GQTCGQHESTS-SQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGF---- 492

Query: 502 RGQKAEAAGEKATAAGAKS-RGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVA---AGAT 557
            GQ    +G+ +      S  G+     Q  +V+G  S  G  +SR RQ +     +G++
Sbjct: 493 -GQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSS 551

Query: 558 SHGGGGNKQSR--GGGGNKPRQWGQTAAAAKTRGGGDKQPGW--------QKAAAGVTKS 607
              G G   SR   G G      GQ+    +   G  +  G+        Q +  G  +S
Sbjct: 552 QSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHES 611

Query: 608 RSGD---GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ 664
           RSG    G   +   +++G G    ++    GQ  + +++   +TG    GSG  Q    
Sbjct: 612 RSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQ---STGFGQYGSGSGQSSGF 668

Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRR---RAKSRGDG------GQNAAVGINPWQRRG 715
               +GS  S+     +         +     ++S G G      GQ +  G +     G
Sbjct: 669 GQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSS-G 727

Query: 716 KKPRLGKSRGGGGAKS----RGSGGAKSRGSGGAKSRSGKKAAASKSHG-------GGGA 764
           +    G+   G G  S     GSG  +S G G  +SRSG+ +    S G       G   
Sbjct: 728 QSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHG 787

Query: 765 KRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
            R+  G  +  SG    T  GQ  + +G           G GQ  +  G+
Sbjct: 788 SRQTSGFGQHGSGSSQSTGFGQYGSGSG--------QSAGFGQHGSGSGQ 829



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 151/769 (19%), Positives = 251/769 (32%), Gaps = 89/769 (11%)

Query: 43   SAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA--GAGGAEN 100
            S+ + G    GSG  +     +A  G+     GQ       E+R H       G+G +++
Sbjct: 801  SSQSTGFGQYGSGSGQ-----SAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQS 855

Query: 101  RGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
             G G+  +++  T   G      + R      +G  +    + +S+  G    G+G    
Sbjct: 856  SGYGQHGSSSGQTSGFG------QHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSG 909

Query: 161  AAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGG 220
                  +S      Q  + +   S  G+     G      + + G  +   S FG+   G
Sbjct: 910  FGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQS--SGFGQHGSG 967

Query: 221  RRKKHRRPKPAAGGAKSRRGGGKKPQK-QRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQ 279
              +     +  +G  KS   G  + +  Q   GQ  +   +S      G    +    GQ
Sbjct: 968  SGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQ 1027

Query: 280  NAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAG 339
            + + +G              + G G  G  S  GQ+  +G+   + R   Q +     +G
Sbjct: 1028 HRSSSGQYSGFGQHGSGSDQSSGFGQHGTGS--GQSSGFGQYESRSR---QSSYGQHGSG 1082

Query: 340  TKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGR 399
            + +  G  Q  +  G  S   Q R G      ++S  G    G G   G  +    G G+
Sbjct: 1083 SSQSSGYGQHGSNSGQTSGFGQHRPGSG----QSSGFGQYGSGSGQSSGFGQ-HGSGTGK 1137

Query: 400  KKPRWQNPRRRAQKAPAAKPRG-----GGSKKPRRRGPKAAK-----------------S 437
                 Q+  R  Q +      G     G  +     GP  +                  S
Sbjct: 1138 SSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHIS 1197

Query: 438  RGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT------KSRGGGL 491
              G+S +G G+     GQ       E+     G    GRQ+ +   T         G G 
Sbjct: 1198 DSGQS-TGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQ 1256

Query: 492  KSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKA 551
             + +G  + RR + +++    +      S    +    +   AG+     GS  R+RQ  
Sbjct: 1257 STQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQ---AGSHYPKSGSTVRRRQGT 1313

Query: 552  V---AAGATSHGGGGNKQSRGGGGN---KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVT 605
                    T HG  G+ QS   G     + R     A  ++   G   +P  Q+      
Sbjct: 1314 THGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQA 1373

Query: 606  KSRSGDGGKKAWRQ---------KAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
             S+ G+       +         +A G G     +  +RG +         +  + S   
Sbjct: 1374 GSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVH 1433

Query: 657  GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGK 716
             G   R Q       E +   A  Q  E+      R   + G  G       +     GK
Sbjct: 1434 SGGSHRPQS-----QEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTR---HAHYHHGK 1485

Query: 717  KPRLGKSRGGGGAKSRGSGGAKSRGS----GGAKSRSGKKAAASKSHGG 761
              + G S  G     RGSG ++S  S    GG+ + SG     S S  G
Sbjct: 1486 STQRGSSTTG----RRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHG 1530



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 158/832 (18%), Positives = 266/832 (31%), Gaps = 129/832 (15%)

Query: 76   QKGAVAGKEARQHWQKAAGAGGAENRG-GGEQKAAAAGTKSLGGRGR-KPRRRGQKAAAT 133
            Q G        +H       G A   G  G  ++   G+++ G RG         +  + 
Sbjct: 1376 QHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSG 1435

Query: 134  GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKS--RSGKKPR 191
            GS +P+ + Q    AGS++  +G+           Q G+  + A     KS  R      
Sbjct: 1436 GSHRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTG 1495

Query: 192  RRGAKSRGDEDKKGRQREAKSRFGKTRGGR-----------RKKHRRPKPAAGGAKSRRG 240
            RRG+      D +     + +  G T G               +HR      G       
Sbjct: 1496 RRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSY 1555

Query: 241  GGKKPQKQ---RRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK---------- 287
             G +   Q   R  G++  +  +S   +   GG  +   +      AG++          
Sbjct: 1556 SGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHE 1615

Query: 288  RRGAA------TAGEKPAAKGRGG-RGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGT 340
            R G        T G   +  G+   RG ++ G Q              G   T       
Sbjct: 1616 RHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHG 1675

Query: 341  KRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRK 400
            + G    Q  ++V  +      + G   R            G   + G R   RRG G  
Sbjct: 1676 QAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYH------HGLTTQTGSRTTGRRGSGHS 1729

Query: 401  K-----------------PRWQNPRRRAQKAPAAKPRGG--------------------- 422
            +                    Q   +  +       R G                     
Sbjct: 1730 EYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQST 1789

Query: 423  --GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAG-AESRGDKKQGR--- 476
              GS+   RR    ++    +  SG  ++P  RG    Q  ++ G +ES  D++ G    
Sbjct: 1790 QTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHG 1849

Query: 477  QKASAAGTKSRGGGLKSHSGKNLW--RRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVA 534
            Q    +G    G G  + SG +    RR   +E++  +  + G+ +       +      
Sbjct: 1850 QTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQ------ 1903

Query: 535  GAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQT----AAAAKTRGG 590
             A+S+ G S+S   ++      T+HG  G+    G   +     GQT    +     RG 
Sbjct: 1904 -ARSQHGESESTVHKR----HQTTHGQTGDTTEHGHPSH-----GQTIQTGSRTTGRRGS 1953

Query: 591  GDKQPGWQKAAAGVTKSRSG-DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWAT 649
            G  +    +  +GV+ + SG   G+       +G+    R         D      +   
Sbjct: 1954 GHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHG 2013

Query: 650  GATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGIN 709
             +T RGS     R      A   S  + + G    +         ++   G Q+   G +
Sbjct: 2014 QSTQRGSRTTGRR------ASGHSEYSDSEGHSGVSHTHSGHAHGQA---GSQHGESGSS 2064

Query: 710  PWQRRG-KKPRLGKS-----RGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKSHGGG 762
              +R G    + G +      G G +  RGS  A  RGSG ++S   +  +  S +H G 
Sbjct: 2065 VHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSG- 2123

Query: 763  GAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
                   G A+S+ GE      G++    G         + G GQ    G +
Sbjct: 2124 ----HTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSR 2171



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 152/769 (19%), Positives = 261/769 (33%), Gaps = 100/769 (13%)

Query: 66   AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRR 125
            +G  ++   GQ G+ +G+ A    Q  +G+G +   G  E ++  +     G    +   
Sbjct: 799  SGSSQSTGFGQYGSGSGQSAG-FGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSG 857

Query: 126  RGQKAAATGSKKP--RWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAK 183
             GQ  +++G      + R+     +G    G+G+ +++             Q    +G  
Sbjct: 858  YGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFG----------QHGTGSGQY 907

Query: 184  SRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGK 243
            S  G+   R    S G       Q     + G + G             G  + R G G+
Sbjct: 908  SGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSG----------QTFGFGQHRSGSGQ 957

Query: 244  KP---QKQRRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPA 299
                 Q     GQ +  G  +S  GKS G G  + R    N    G+    ++  G+  +
Sbjct: 958  SSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGS 1017

Query: 300  AKGR--GGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
            + G+  G    +S  GQ   +G+ G          +  ++   + G G  Q +     +S
Sbjct: 1018 SSGQTTGFGQHRSSSGQYSGFGQHGS--------GSDQSSGFGQHGTGSGQSSGFGQYES 1069

Query: 358  RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
            R +Q   G+         +G+    G  + G    +  G G+ +P        + ++   
Sbjct: 1070 RSRQSSYGQH-------GSGSSQSSGYGQHGSNSGQTSGFGQHRPG-------SGQSSGF 1115

Query: 418  KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG--DKKQG 475
               G GS +    G   + +  GKS SG  +   R GQ +  +     ++S G    + G
Sbjct: 1116 GQYGSGSGQSSGFGQHGSGT--GKS-SGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESG 1172

Query: 476  RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
                ++ G    G    S SG+++   GQ     G+  + +G +S G  Q   Q+     
Sbjct: 1173 SGPTTSFGQHVSGSDNFSSSGQHISDSGQST-GFGQYGSGSG-QSTGLGQGESQQ---VE 1227

Query: 536  AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK--------- 586
            + S V G +     + +     S  G G     G    + R+  Q+  +           
Sbjct: 1228 SGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHR 1287

Query: 587  ------TRGGGD--KQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR-GQ 637
                  T+ G    K     +   G T  + GD  +         T   SR    +R   
Sbjct: 1288 HSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSH 1347

Query: 638  KDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR 697
             DA  +E    +G + R    +Q   Q    AGS+   + +   E       +   A   
Sbjct: 1348 SDATDSEVH--SGVSHRPHSQEQTHSQ----AGSQHGESESTVHERHETTYGQTGEATGH 1401

Query: 698  GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASK 757
            G  G   +       +RG +      R G G          S GS   +S+      A  
Sbjct: 1402 GHSGHGQST------QRGSRTT---GRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGS 1452

Query: 758  SHG-GGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
             HG  G     R G    ++G+       + A    GK   R  S  GR
Sbjct: 1453 QHGESGSTVHGRHGTTHGQTGDTT-----RHAHYHHGKSTQRGSSTTGR 1496



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 110/628 (17%), Positives = 191/628 (30%), Gaps = 111/628 (17%)

Query: 205  GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVG 264
            GR+    S +  + G     H       G A+S+ G  +    +R       TG  +R  
Sbjct: 1722 GRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHA 1781

Query: 265  KSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
             S  G           +   G++  G  ++G    +   G  G               ++
Sbjct: 1782 HSGHG----------QSTQTGSRTTGRRSSGHSEYSDSEGHSG-------------FSQR 1818

Query: 325  PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGG 384
            P  RG             G  G Q      +   +     G+       S +G    G  
Sbjct: 1819 PHSRGHT----------HGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSG---HGQS 1865

Query: 385  DKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRS 444
             + G     RR  G  +            +  ++   GGS          A+S+ G+S S
Sbjct: 1866 TQSGSSTTGRRRSGHSE------------SSDSEVHSGGSHTHSGHTHSQARSQHGESES 1913

Query: 445  GGGKKPR----------RRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
               K+ +            G  +  +  + G+ + G +  G  + S   ++   G   +H
Sbjct: 1914 TVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYS--DSEGPSGVSHTH 1971

Query: 495  SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKA--- 551
            SG    + G     +G         + G+     +       +S   GS++  R+ +   
Sbjct: 1972 SGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHS 2031

Query: 552  VAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGD 611
              + +  H G  +  S    G    Q G++ ++   R G              T  ++GD
Sbjct: 2032 EYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHG-------------TTHGQTGD 2078

Query: 612  GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGS 671
              + A       T   SR    RRG   + +++    +G +   SG              
Sbjct: 2079 TTRHAHSGHGQSTQRGSRTAG-RRGSGHSESSDSEVHSGVSHTHSG-------------- 2123

Query: 672  ESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKS 731
              +   A  Q  E+      R+    G  G                 R G+S  G   ++
Sbjct: 2124 -HTYGQARSQHGESGSAIHGRQGTIHGQTGDTT--------------RHGQSGHGQSTQT 2168

Query: 732  RGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAA 791
                  + R S    S S   + AS +H G          A SR G+   +  G++    
Sbjct: 2169 GSRTTGRQRSSHSESSDSEVHSEASPTHSG-----HTHSQAGSRHGQSGSSGHGRQGTTH 2223

Query: 792  GGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
            G        +  G GQ    G +   RR
Sbjct: 2224 GQTGDTTRHAHYGYGQSTQRGSRTTGRR 2251



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 154/850 (18%), Positives = 267/850 (31%), Gaps = 130/850 (15%)

Query: 75   GQKGAVAGKEA---------RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG-RGRKPR 124
            GQ G  +G+ +         RQ      G+G +++ G G+  + +  T   G  R    +
Sbjct: 1052 GQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQ 1111

Query: 125  RRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKS 184
              G     +GS +     Q  +  G K+ G    +  +      Q G    +++  G + 
Sbjct: 1112 SSGFGQYGSGSGQSSGFGQHGSGTG-KSSGFAQHEYRSGQSSYGQHGTGSSQSSGCG-QH 1169

Query: 185  RSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG-GRRKKHRRPKPAAGGAKSRR---G 240
             SG  P     +     D      +  S  G++ G G+           G  +S++   G
Sbjct: 1170 ESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESG 1229

Query: 241  GGKKPQKQRRRGQKAATGGKSRVGKSR----GGGDKKLRRQGQNAALAGAKRRGAATAGE 296
                 +++   GQ   T   S+ G+ +    G    + RR  Q+           +    
Sbjct: 1230 STVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHS 1289

Query: 297  KPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVK 356
            +      G   PKS           G   RRR           T+ G  G  ++   G +
Sbjct: 1290 EHIHTQAGSHYPKS-----------GSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSR 1338

Query: 357  SRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPA 416
            +  +QR         +  +  +      ++   +   + G+       ++     Q   A
Sbjct: 1339 TSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEA 1398

Query: 417  A--------KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAG--- 465
                     +    GS+   RRG   ++S   +  SGG  +P+ + Q   Q  ++ G   
Sbjct: 1399 TGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESG 1458

Query: 466  ---------------------------AESRGDKKQGRQ---KASAAGTKSRGGGLKSHS 495
                                       +  RG    GR+    + ++ ++   GG  +HS
Sbjct: 1459 STVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHS 1518

Query: 496  GKNLWRRGQKAEAAGEKATAAGAKSR---GRKQPRRQKPAVAGAKSRVGGSKSRQRQKAV 552
            G      GQ     GE  +    + R   G+     +       ++   GS++  RQ+  
Sbjct: 1519 GHT---HGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQR-- 1573

Query: 553  AAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQ-KAAAGVTKSRSGD 611
                TSH    + +   GG ++P     T   A   G   ++P +      G T  + GD
Sbjct: 1574 ----TSHSESTDSEVHSGGSHRPHSREHTYGQA---GSQHEEPEFTVHERHGTTHGQIGD 1626

Query: 612  ------GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQK 665
                   G     Q+ + T  + R         +  +      TG T   +G +  + + 
Sbjct: 1627 TTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSES 1686

Query: 666  --PAAAGSESSAAAAV--------GQEAEARKKPRRRRAKSRGD--------GGQNAAVG 707
              P   G+                G   +   +   RR     +        G  +   G
Sbjct: 1687 IVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSG 1746

Query: 708  INPWQRRGK--------KPRLGKSRGGGGAKSR----GSGGAKSRGSGGAKSRSGKKAAA 755
                Q R +          R G   G  G  +R    G G +   GS     RS   +  
Sbjct: 1747 HTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEY 1806

Query: 756  SKSHGGGGAKRR---RG---GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKA 809
            S S G  G  +R   RG   G A S+ GE       +     G        S+ G GQ  
Sbjct: 1807 SDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQST 1866

Query: 810  AAGGKKPLRR 819
             +G     RR
Sbjct: 1867 QSGSSTTGRR 1876


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 95/555 (17%), Positives = 182/555 (32%), Gaps = 78/555 (14%)

Query: 74   RGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRG----QK 129
            RG      G    +HWQ      G +++G GE +    G K L  +    +R G    QK
Sbjct: 654  RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713

Query: 130  AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKK 189
                G +K R   Q+    G +  G G ++           G++ ++    G     G+ 
Sbjct: 714  EREQGHQKER--NQEMEEGGEEEHGEGEEEE----------GDREEEEEKEGEGKEEGEG 761

Query: 190  PRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR 249
                G + + + ++K  +R  K   G+  G + +         G  K   G  +  + + 
Sbjct: 762  EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE 821

Query: 250  RRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK 309
             +G++     +    +  G G+++     +       +  G    GE+   +G G    +
Sbjct: 822  GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881

Query: 310  SLGGQNPRWGRG-GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKP 368
               G+    G G G++    G+   +    G +  G G                      
Sbjct: 882  EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG---------------------- 919

Query: 369  RRQKASAAGAKSRGGGDKKGLREAKRRGDG---RKKPRWQNPRRRAQKAPAAKPRGGGSK 425
               K    G +  G G+++        G+G    ++  W+      +        G G +
Sbjct: 920  ---KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE--------GEGEE 968

Query: 426  KPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG---DKKQGRQKASAA 482
            +    G +      G+   G G+     G++  ++  E   E  G   ++++G  +    
Sbjct: 969  EGEGEGEEGEGE--GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026

Query: 483  GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
            G +  G G             ++ E  GE+    G     R+   R++      K +  G
Sbjct: 1027 GEEGEGEG-----------EEEEGEEEGEEREKEGEGEENRR--NREEEEEEEGKYQETG 1073

Query: 543  SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAA 602
             +  +RQ        S   G  K  +        +  Q  +   T+G G +Q       +
Sbjct: 1074 EEENERQDGEEYKKVSKIKGSVKYGK-------HKTYQKKSVTNTQGNGKEQRSKMPVQS 1126

Query: 603  GVTKSRSGDGGKKAW 617
                     G KK W
Sbjct: 1127 KRLLKNGPSGSKKFW 1141



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 97/550 (17%), Positives = 195/550 (35%), Gaps = 35/550 (6%)

Query: 234  GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQN----AALAGAKRR 289
            GA+  +G G + Q+     +           K  GG  +K      +    A ++  K +
Sbjct: 592  GAEDSKGNGIEEQEVEANEENV---------KVHGGRKEKTEILSDDLTDKAEVSEGKAK 642

Query: 290  GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
                A + P  +G G     S G ++ +     K  + +G+   +    G K     ++ 
Sbjct: 643  SVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEW 702

Query: 350  AAVVGVKSRKKQRRRG-KKPRRQKASAAGAKSRGGGDKK-GLREAKRRGDGRKKPRWQNP 407
                G +  +K+R +G +K R Q+    G +  G G+++ G RE +   +G  K   +  
Sbjct: 703  KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE 762

Query: 408  RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA-AEAGA 466
                ++    +   G  KK  R G +      G    G  ++   RG++  +    E G 
Sbjct: 763  EVEGER----EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGE 818

Query: 467  ESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ-KAEAAGEKATAAGAKSRGRKQ 525
               G  ++  ++    G +  G G +   G+     G+ K E  GE+         G  +
Sbjct: 819  VEEGKGEREEEEEEGEGEEEEGEG-EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877

Query: 526  PRRQKPAVAGAKSRVGGSKSRQ-----RQKAVAAGATSHGGG-GNKQSRGGGGNKPRQWG 579
               ++    G +   G  +  +      ++    G    G G G ++   G G    + G
Sbjct: 878  GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937

Query: 580  QTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKD 639
            +         G +++  W+    G  +   G+G ++   +   G G    ++    G+++
Sbjct: 938  EGEGEDGEGEGEEEEGEWE----GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993

Query: 640  AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
                E          G G  +   +       E       G+E E  ++   R  +  G+
Sbjct: 994  EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER--EKEGE 1051

Query: 700  GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGS-GGAKSRSGKKAAASKS 758
            G +N        +  GK    G+              +K +GS    K ++ +K + + +
Sbjct: 1052 GEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNT 1111

Query: 759  HGGGGAKRRR 768
             G G  +R +
Sbjct: 1112 QGNGKEQRSK 1121



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 61/319 (19%), Positives = 106/319 (33%), Gaps = 22/319 (6%)

Query: 462 AEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE-KATAAGAKS 520
           AE G E RGD           GT   G     H       +G+K +  GE +    G K 
Sbjct: 647 AEDGPEGRGD-----------GTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695

Query: 521 RGRKQPRRQKPAVAGA-KSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG 579
              K+  +++       K R  G +  + Q+    G   HG G  ++  G    +  + G
Sbjct: 696 LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG--EEEEGDREEEEEKEG 753

Query: 580 QTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKD 639
           +     K  G G++  G ++   G  K      GK+   ++    G    ++   RG++ 
Sbjct: 754 E----GKEEGEGEEVEGEREKEEGERKKEER-AGKEEKGEEEGDQGEGEEEETEGRGEEK 808

Query: 640 AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
               E     G    G G ++   ++      E       G+  E   + +       G+
Sbjct: 809 EEGGEVEG--GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866

Query: 700 GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSH 759
           G +    G    +    +    +   G G +  G G  +  G G  +   G+     +  
Sbjct: 867 GEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926

Query: 760 GGGGAKRRRGGGAKSRSGE 778
            G G      G  +   GE
Sbjct: 927 EGEGEGEEEEGEGEGEDGE 945



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 65/376 (17%), Positives = 131/376 (34%), Gaps = 27/376 (7%)

Query: 53   GSGDKKLRRQKAAAGGKKA-RLRGQKGAVAGK-EARQHWQKAAGAGGAENRGGGEQKAAA 110
            G   K+ R  K   G ++  +  G++    G+ E ++   +  G    E +G  E++   
Sbjct: 773  GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE 832

Query: 111  AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQG 170
               +   G G +    G++    G  +      +    G +  G G ++     G +   
Sbjct: 833  GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGE 892

Query: 171  GE-KPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
            GE + ++    G +   G+     G + +G+E+ +  + E +   G+  G   +     +
Sbjct: 893  GEGEEEEGEGEGEEEGEGEGEEEEG-EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEE 951

Query: 230  PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRG---GGDKKLRRQGQNAALA-- 284
                  +   G G+  ++    G++    G+   G+  G    G+++   +G+       
Sbjct: 952  EGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG 1011

Query: 285  -GAKRRGAATAGEKPAAKGRG---GRGPKSLGGQNPRWGRGGKKPRRRGQ------KATK 334
             G +       GE    +G G       +  G +  + G G +  R R +      K  +
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071

Query: 335  AAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
                  +R  G + K     V   K   + GK    QK S    +  G   +  +    +
Sbjct: 1072 TGEEENERQDGEEYKK----VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSK 1127

Query: 395  R----GDGRKKPRWQN 406
            R    G    K  W N
Sbjct: 1128 RLLKNGPSGSKKFWNN 1143



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 70/406 (17%), Positives = 135/406 (33%), Gaps = 28/406 (6%)

Query: 53   GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAG-GAENRGGGEQKAAAA 111
            G G ++   ++     +K     +K   AGKE +   +   G G   E  G GE+K    
Sbjct: 753  GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812

Query: 112  GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG 171
              +       K  R  ++    G ++     ++    G +  G G        G + +G 
Sbjct: 813  EVEGGEVEEGKGEREEEEEEGEGEEE-EGEGEEEEGEGEEEEGEG---KGEEEGEEGEGE 868

Query: 172  EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
            E+ ++    G +     +    G     +E+ +G   E     G+   G  K     +  
Sbjct: 869  EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG 928

Query: 232  AGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGA 291
             G  +   G G+        G+     G+   G+  G        +G+       +  G 
Sbjct: 929  EGEGEEEEGEGE--------GEDGEGEGEEEEGEWEGE-----EEEGEGEGEEEGEGEGE 975

Query: 292  ATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA 351
               GE    +G G    +    +    G G ++    G++  +    G   G  G+ +  
Sbjct: 976  EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035

Query: 352  VVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQ------ 405
                +   ++R +  +    + +    +   G  ++   E   R DG +  +        
Sbjct: 1036 EEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSV 1095

Query: 406  --NPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK 449
                 +  QK      +G G K+ R + P  +K R  K+   G KK
Sbjct: 1096 KYGKHKTYQKKSVTNTQGNG-KEQRSKMPVQSK-RLLKNGPSGSKK 1139


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 84/393 (21%), Positives = 156/393 (39%), Gaps = 32/393 (8%)

Query: 97  GAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRA-QKSAAAGSKNRGA 155
           G+E  G   +KA      S      K +        T  K+ + R+ +++     K +  
Sbjct: 143 GSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSK 202

Query: 156 GAQKAAAAAGVKSQGGEK-----PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
           G  +       +S+  E+     P K + +  ++R  K P  R    R  ++K G+ R  
Sbjct: 203 GGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLR----RRSQEKIGKARSP 258

Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
                K     + K R+  P    ++SR  G K       RG+      +S+  KS+   
Sbjct: 259 TDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSE 318

Query: 271 DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK--SLGGQNPRWGRGGKKPRRR 328
             K ++  ++ +      + A++  E  +   R GR PK  SL  +     R  + P   
Sbjct: 319 TDKEKKPIKSPS------KDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLN 372

Query: 329 GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR----------RQKASAAGA 378
            +++ ++ +       G + K+  +  K R+ +RRR   PR          R+++  A  
Sbjct: 373 DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASP 432

Query: 379 KSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR 438
            +R    ++  R   RR       R ++PRRR+ ++P  + RG  S+   RR    ++SR
Sbjct: 433 INRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRS-RSPRRRDRGRRSRSRLRR---RSRSR 488

Query: 439 GGKSRSGGGKKPRRRGQKARQKAAEAGAESRGD 471
           GG+ R    K    + + +  +  +   ES  D
Sbjct: 489 GGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSD 521



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 98/483 (20%), Positives = 181/483 (37%), Gaps = 85/483 (17%)

Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG 242
           K +   K ++    S  D+DKK + +            + KKH+R +      K      
Sbjct: 47  KHKHRSKHKKHKHSSEEDKDKKHKHKH-----------KHKKHKRKEIIDASDKEGMSPA 95

Query: 243 KKPQ----------KQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGA----KR 288
           K+ +          +++R   KA    +   GK + G    L+     +   G      R
Sbjct: 96  KRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKAR 155

Query: 289 RGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQ 348
            G  ++    + KG+       +  +     R  ++ R R  K         K+  GG +
Sbjct: 156 NGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDK---------KKSKGGIE 206

Query: 349 KAAVVGVKSRKKQRRRGKKPRRQKASAAGA-----------------KSRGGGDKKGLRE 391
                  +S+ K+R++ K P ++  S   A                 K+R   D K   E
Sbjct: 207 IVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIE 266

Query: 392 AKRRGDGRKK-PRWQNPRRRAQKAPAAKPRG-GGSKKPRRRGPKAAKSRGGKSRSGGGKK 449
            K +   RKK P     R R +   +  P    G  K RR   K  KS+  +S +   KK
Sbjct: 267 DKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSK--RSETDKEKK 324

Query: 450 PRRRGQKARQKAAEAGAESRG-DKKQGRQ-KASAAGTKSRGGGLKSHSGKNLWRRGQKAE 507
           P     K+  K A +G E+R   ++ GR  K  +   K R    +S S     RR ++++
Sbjct: 325 P----IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSK 380

Query: 508 AAGEK-ATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQ 566
           +     +    AKSR  ++ RR+       + R+   ++R R   +           +++
Sbjct: 381 SPSRTLSPGRRAKSRSLERKRREP-----ERRRLSSPRTRPRDDIL-----------SRR 424

Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
            R    +   +W  T   +++       P  +++ + + +SRS     ++ R++  G  +
Sbjct: 425 ERSKDASPINRWSPTRRRSRS-------PIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRS 477

Query: 627 KSR 629
           +SR
Sbjct: 478 RSR 480



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 97/498 (19%), Positives = 187/498 (37%), Gaps = 71/498 (14%)

Query: 356 KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK------PRWQNPRR 409
           + +KK+ +   K ++ K S+   K     DKK   + K +   RK+          +P +
Sbjct: 42  RHKKKKHKHRSKHKKHKHSSEEDK-----DKKHKHKHKHKKHKRKEIIDASDKEGMSPAK 96

Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR 469
           R +    A       ++   +     +   GK +SG G            +  E+G+E  
Sbjct: 97  RTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMG---------LILQGYESGSEEE 147

Query: 470 GDKKQGRQKASAAGTKSRG--GGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPR 527
           G+  +  +  + + T+S    G L+    K   ++  K+ +          ++R R   +
Sbjct: 148 GEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK--------ERTRHRSDKK 199

Query: 528 RQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW----GQTAA 583
           + K  +   K +   SKS++R+K+ +    S      ++S+     +  Q      ++  
Sbjct: 200 KSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPT 259

Query: 584 AAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKA-----WRQKAAGTGAKSR--------- 629
             K +     +   +K +  + +SRS D GKK+      R K+    ++S+         
Sbjct: 260 DDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSET 319

Query: 630 ---KKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
              KKP +   KDA++ ++  +       S  ++    KP      S +     + ++  
Sbjct: 320 DKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQS 379

Query: 687 KKPRR-----RRAKSRGDGGQNAAVGINPWQRRGKKPRLG----------KSRGGGGAKS 731
           K P R     RRAKSR    +       P +RR   PR            +S+       
Sbjct: 380 KSPSRTLSPGRRAKSRSLERKRR----EPERRRLSSPRTRPRDDILSRRERSKDASPINR 435

Query: 732 RGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRR-RGGGAKSRSGEKAVTAGGQKAAA 790
                 +SR     +SRS  + + S        +RR RG  ++SR   ++ + GG++  +
Sbjct: 436 WSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRS 495

Query: 791 AGGKKPPRVKSRGGRGQK 808
               K  + K     G K
Sbjct: 496 RSKVKEDKFKGSLSEGMK 513


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 215/871 (24%), Positives = 272/871 (31%), Gaps = 115/871 (13%)

Query: 3    YRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQ 62
            +RG    + A G AGP  P G     +P E  A              +    G    R  
Sbjct: 267  HRGFSGLDGAKGDAGPAGPKGE--PGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGN 324

Query: 63   KAAAGGK-------KARLRGQKGAVA--GKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
              A G          A   G  GAV   G+   Q  + + G  G     G    A AAG 
Sbjct: 325  DGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGP 384

Query: 114  KSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGE- 172
                G   +P  +G   A   +  P +   +          +G Q      G K   GE 
Sbjct: 385  AGNPGADGQPGAKGANGAPGIAGAPGFPGARGP--------SGPQGPGGPPGPKGNSGEP 436

Query: 173  -KPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQRE-AKSRFGKTRGGRRKKHRRPKP 230
              P      GAK   G    +      G+E K+G + E   +      G R     R  P
Sbjct: 437  GAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFP 496

Query: 231  AAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRG 290
             A G    +G   +      RG     G K   G++   G+         A L GAK  G
Sbjct: 497  GADGVAGPKGPAGE------RGSPGPAGPKGSPGEAGRPGE---------AGLPGAK--G 539

Query: 291  AATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKA 350
               +   P   G+   GP    GQ+ R G  G  P  RGQ A      G K   G   KA
Sbjct: 540  LTGSPGSPGPDGK--TGPPGPAGQDGRPGPPG-PPGARGQ-AGVMGFPGPKGAAGEPGKA 595

Query: 351  AVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRR 410
               GV         G      K   AGA+   G        A   G+  ++    +P  +
Sbjct: 596  GERGVPGPP-----GAVGPAGKDGEAGAQGPPG-------PAGPAGERGEQGPAGSPGFQ 643

Query: 411  AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK-PRRRG-QKARQKAAEAGAES 468
                PA  P  G + KP  +G        G S + G +  P  RG Q     A   GA  
Sbjct: 644  GLPGPAGPP--GEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANG 701

Query: 469  RGDKKQGRQKASAAGTKSRGG--GLKSHSGKN-----LWRRGQKAEAAGEKATAAGAKS- 520
                   +  A A G     G  GL+   G+         +G + +A  + A  +  K  
Sbjct: 702  APGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDG 761

Query: 521  -RGRKQPRRQKPAVAGAKSRVGGS-KSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW 578
             RG   P    P  AGA    G S  S       A GA    G        G    P   
Sbjct: 762  VRGLTGP-IGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGAD 820

Query: 579  GQTAAAAKTRGGGDKQPGWQKAAAGVTK-----SRSGDGGKKAWRQKAAGTGAKS-RKKP 632
            GQ  A  +    G K        AG           G  G K  R  A   GA       
Sbjct: 821  GQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAA 880

Query: 633  WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ--------------KPAAAGSESSAAAA 678
             R G    +           +   GGK PR +               P  AG + S  A 
Sbjct: 881  GRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGAD 940

Query: 679  VGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR--------RGKKPRLGKSRGGGGAK 730
                A     P       +G  GQ   VG+ P QR         G     GK    G + 
Sbjct: 941  GPAGAPGTPGP-------QGIAGQRGVVGL-PGQRGERGFPGLPGPSGEPGKQGPSGASG 992

Query: 731  SRGSGGAKS-RGSGGAKSRSGKKAAASKSHGGGGAKRRRGG-GAKSRSGE--KAVTAGGQ 786
             RG  G     G  G    SG++ A     G  G+  R G  GAK   GE   A   G  
Sbjct: 993  ERGPPGPMGPPGLAGPPGESGREGAP----GAEGSPGRDGSPGAKGDRGETGPAGPPGAP 1048

Query: 787  KAAAAGGKKPPRVKSRGGRGQKAAAGGKKPL 817
             A  A G   P  KS G RG+   AG   P+
Sbjct: 1049 GAPGAPGPVGPAGKS-GDRGETGPAGPAGPV 1078



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 202/841 (24%), Positives = 262/841 (31%), Gaps = 93/841 (11%)

Query: 5    GHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAA----PALSAAAAGVKILGSGDKKL 59
            G R  + A G AGP  P G A     P  + A+  A    P  S    GV+    G+   
Sbjct: 320  GARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVR----GEPGP 375

Query: 60   RRQKAAAG-GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG 118
                 AAG        GQ GA  G         A G  GA    G +      G K   G
Sbjct: 376  PGPAGAAGPAGNPGADGQPGA-KGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSG 434

Query: 119  RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK----- 173
                P  +G    A G   P         AG + +  GA+      G+    GE+     
Sbjct: 435  EPGAPGSKGD-TGAKGEPGPVGVQGPPGPAGEEGK-RGARGEPGPTGLPGPPGERGGPGS 492

Query: 174  ---PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGK----TRGGRRKKHR 226
               P     AG K  +G++     A  +G   + GR  EA     K    + G      +
Sbjct: 493  RGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGK 552

Query: 227  RPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGA 286
               P   G   R G    P  + + G     G K   G+    G++ +   G   A+  A
Sbjct: 553  TGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGV--PGPPGAVGPA 610

Query: 287  KRRGAATAGEKPAAKGRGG-RGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
             + G A A   P   G  G RG +   G     G  G  P     +A K    G     G
Sbjct: 611  GKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPG--PAGPPGEAGKPGEQGVPGDLG 668

Query: 346  GQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGD-KKGLREAKRRGDGRKKPRW 404
                +   G   R     RG +     A   GA    G D  KG   A      +  P  
Sbjct: 669  APGPSGARG--ERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGL 726

Query: 405  QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEA 464
            Q        A    P+G         GPK A    GK    G   P             A
Sbjct: 727  QGMPGERGAAGLPGPKGDRGDA----GPKGADGSPGKDGVRGLTGPIG-------PPGPA 775

Query: 465  GAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE-KATAAGAKSRGR 523
            GA   GDK +      A  T +RG              G + E      A  AG      
Sbjct: 776  GAP--GDKGESGPSGPAGPTGARGAP------------GDRGEPGPPGPAGFAGPPGADG 821

Query: 524  KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH-GGGGNKQSRGGGGNKPRQWGQTA 582
            +   + +P  AGAK   G         A   G   + G  G K +RG  G  P   G   
Sbjct: 822  QPGAKGEPGDAGAKGDAG--PPGPAGPAGPPGPIGNVGAPGAKGARGSAG-PPGATGFPG 878

Query: 583  AAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK-------KPWRR 635
            AA +    G   P       G      G  GK+  +     TG   R         P   
Sbjct: 879  AAGRV---GPPGPSGNAGPPGPP----GPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPA 931

Query: 636  GQKDAAAAE-KAWATGATS-RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR 693
            G+K +  A+  A A G    +G  G++     P   G E       G   E  K+     
Sbjct: 932  GEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRG-ERGFPGLPGPSGEPGKQGPSGA 990

Query: 694  AKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKA 753
            +  RG  G        P    G     G+S   G   + GS G    GS GAK   G+  
Sbjct: 991  SGERGPPG--------PMGPPGLAGPPGESGREGAPGAEGSPGRD--GSPGAKGDRGETG 1040

Query: 754  AASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG--GKKPPRVKSRGGRGQKAAA 811
             A      G        G   +SG++  T     A   G  G + P    +G RG K   
Sbjct: 1041 PAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGP-AGPQGPRGDKGET 1099

Query: 812  G 812
            G
Sbjct: 1100 G 1100



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 188/784 (23%), Positives = 244/784 (31%), Gaps = 103/784 (13%)

Query: 73  LRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAA 132
           L G  GA  G +  Q      G  GA    G        G     G   KP R G++   
Sbjct: 189 LPGPPGA-PGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPP 247

Query: 133 TGSKKPRWRAQKSAAAGSK-NRGA----GAQKAAAAAGVKSQGGEKPQKAAAA-----GA 182
            G +  R     +   G K +RG     GA+  A  AG K + G   +  A       G 
Sbjct: 248 -GPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGL 306

Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG-- 240
               G+      A +RG++   G    A    G T            P A GAK   G  
Sbjct: 307 PGERGRPGAPGPAGARGNDGATG----AAGPPGPTGPAGPPGF----PGAVGAKGEAGPQ 358

Query: 241 ---GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEK 297
              G + PQ  R  G+    G     G +   G       GQ  A       G A A   
Sbjct: 359 GPRGSEGPQGVR--GEPGPPGPAGAAGPAGNPG-----ADGQPGAKGANGAPGIAGAPGF 411

Query: 298 PAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
           P A  RG  GP+  GG     G  G+             A G+K   G + +   VGV+ 
Sbjct: 412 PGA--RGPSGPQGPGGPPGPKGNSGEP-----------GAPGSKGDTGAKGEPGPVGVQG 458

Query: 358 RKKQR-RRGKKPRRQKASAAGAKS----RGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQ 412
                   GK+  R +    G       RGG   +G   A    DG   P+     R + 
Sbjct: 459 PPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGA----DGVAGPKGPAGERGSP 514

Query: 413 KAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGG--GKK--PRRRGQKARQ-------KA 461
                K   G + +P   G   AK   G   S G  GK   P   GQ  R          
Sbjct: 515 GPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGAR 574

Query: 462 AEAGAESRGDKKQGRQKASAAGTKSRGG--GLKSHSGKNLWRRGQKAEAAGEKATAAGAK 519
            +AG       K    +   AG +   G  G    +GK+      +A A G    A  A 
Sbjct: 575 GQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKD-----GEAGAQGPPGPAGPAG 629

Query: 520 SRGRKQPRRQKPAVAGAKSRVG--GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQ 577
            RG + P    P   G     G  G   +  ++ V     + G  G +  RG  G +  Q
Sbjct: 630 ERGEQGPAGS-PGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQ 688

Query: 578 WGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQ 637
                A  +   G     G  K  AG   +  G  G    +      GA     P  +G 
Sbjct: 689 GPPGPAGPRGANGAPGNDG-AKGDAGAPGA-PGSQGAPGLQGMPGERGAAGLPGP--KGD 744

Query: 638 KDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR 697
           +  A  + A        GS GK          G    A A  G + E+          +R
Sbjct: 745 RGDAGPKGA-------DGSPGKDGVRGLTGPIGPPGPAGAP-GDKGESGPSGPAGPTGAR 796

Query: 698 GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSR-GSGGAKSRSGKKAAAS 756
           G  G            RG+    G +   G   + G  GAK   G  GAK  +G    A 
Sbjct: 797 GAPGD-----------RGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAG 845

Query: 757 KSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG----RGQKAAAG 812
            +   G        GAK   G            AAG   PP      G     G     G
Sbjct: 846 PAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEG 905

Query: 813 GKKP 816
           GK P
Sbjct: 906 GKGP 909


>gi|239757861 PREDICTED: similar to armadillo repeat containing,
            X-linked 4 [Homo sapiens]
          Length = 2382

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 173/835 (20%), Positives = 290/835 (34%), Gaps = 99/835 (11%)

Query: 9    CNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGG 68
            C++ + ++  GA     +       A E A+  L A     +   +GDK       A  G
Sbjct: 1250 CDETSVKSWAGARAENVVGIGTWARAGEQASGGLWAGGQTSEGTWAGDKA---SGGAWTG 1306

Query: 69   KKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQ 128
             + +  G   A+AG +A      A  A      GG     +  G +++GG       +  
Sbjct: 1307 AENQASGGSWALAGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTGAENQAS 1366

Query: 129  KAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQ-KAAAAGAKSRSG 187
            + +  G+      +    A      G G+    A    +S GG KP+ +  A+G  S +G
Sbjct: 1367 EGSWAGAGAGNMSSVSYWAGVVDQAGGGSW---AGTSDQSGGGSKPRFEDQASGEGSWAG 1423

Query: 188  KKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH--RRPKPAAGGAKSRRGGGKKP 245
               +  G    G ED+   +  A +   +  GG R  H  +    A  G   + GGG KP
Sbjct: 1424 AGGQASGGSMLGPEDQSSGRSWADTA-DQASGGSRLGHVDQSSGGAWAGTLDQSGGGSKP 1482

Query: 246  QKQRRRGQKAATGGKSRVGKSRGGGDK---KLRRQGQNAALAGAKRRGAATAGEKPAAKG 302
            + + +  ++ +  G    G   GGG K   + +  G++ A +G +  G    G    A G
Sbjct: 1483 RFENQTTEEGSWAG---AGGQAGGGSKVGPEDQSSGRSWANSGDQISGGFLVGIVDQANG 1539

Query: 303  RGGRG---PKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRK 359
                G   P S+G           KP    Q + + + A  +    G  +  +    S  
Sbjct: 1540 GSWTGAGHPASVG----------PKPIFEDQVSGRGSWADAREQVVGDSRLGLRDQSSGD 1589

Query: 360  KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR-------WQNPRRRAQ 412
                 G +         G+++ GG    G    +  G  R  P        W +P  +  
Sbjct: 1590 SWAGTGDQASGWFCVCPGSQTNGGS--WGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVS 1647

Query: 413  KA----PAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGA 466
             +      A  + GG  KP             G   ++GGG +P              G+
Sbjct: 1648 GSCWTGAGAVDQAGGCSKPGFEDQAIGGGFWPGAGDQTGGGSRP--------------GS 1693

Query: 467  ESRGDKKQGRQKASAAGTKSRGG---GLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR 523
            E   D+  G      AG +  GG   G    S    W  G   +++G      G ++   
Sbjct: 1694 E---DQSSGIGSWGVAGGQVLGGARPGPADQSSGGSWA-GTGNQSSGRSWIGPGDQAVDC 1749

Query: 524  KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGG--GNKPRQWGQT 581
             +P  +  A  G      GS+        A+G +  G     ++ GG   G++ +  G +
Sbjct: 1750 SKPEFEDQACGGGSWAGAGSQ--------ASGESWAGSRPGNEAIGGSRMGSEDQATGGS 1801

Query: 582  AAAAKTRGGGDKQPGWQ-KAAAGVTKSRSGDG--GKKAWRQKAAGTGAKSRKKPWRRGQK 638
             A ++ +  G  Q  ++ +A  G       +   G   W ++ A   ++   K       
Sbjct: 1802 WARSEDQASGRFQVSFEVEANEGFWFGPGAEAVIGSWCWTEEKADIVSRPDDKDEATTAS 1861

Query: 639  DAAAAEKAWATG---ATSRGSGGKQPRWQK----------PAAAGSESSAAAAVGQEAEA 685
             + A E+A       A ++ S G   R ++           A AG+E+ A A  G  A A
Sbjct: 1862 RSRAGEEAMICSRIEAENKASSGSWIRSEEVAYMGSCVGAEAGAGAEAGAGAEAGAGAGA 1921

Query: 686  RKKPRRRRAKSRGDGGQNAAVGINPWQRRGK--KPRLGKSRGGGG-----AKSRGSGGAK 738
                        G G ++ A G+  W       + RLG     G      A++ G     
Sbjct: 1922 EAGAEAGAGAGAGPGTESGA-GVWSWDGDATTVESRLGAGEEAGVESWTLARNVGEDELS 1980

Query: 739  SRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGG 793
               S   +  S +    ++S      + + G  A   SG    T+   K  AAGG
Sbjct: 1981 RESSPDIEEISLRSLFWAESENSNTFRSKSGKDASFESGAGDNTSIKDKFEAAGG 2035



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 176/889 (19%), Positives = 283/889 (31%), Gaps = 160/889 (17%)

Query: 41   ALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAG-GAE 99
            A+S A AG+   GS      + +A A      L G K  V G     +W   + AG G +
Sbjct: 866  AVSKAEAGMGATGSV-----QPQAVANSHCETLPGAKNKVRG-----NWNAVSKAGAGMD 915

Query: 100  NRGGGEQKAAA-------AGTKS-LGGRGRKPRRRGQKAAATGSKKPRWRA--QKSAAAG 149
             RG  + +A A        G K+ + G      + G +    GS +P+  A  Q+    G
Sbjct: 916  TRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGSTQPQVLASSQRETLPG 975

Query: 150  SKNRGAGAQKAAAAAGVK--SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGR- 206
            ++N+  G     + AG +  + G  +PQ  A +  ++  G + + +G  +   + + G  
Sbjct: 976  ARNKVKGNSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGAG 1035

Query: 207  -----QREAKSRF-GKTRGGRRKKHRRPKPAAGGAKSRRG--GGKKPQKQRRRGQKAATG 258
                 Q +  + F G+   G + K R    A   A++     G  +PQ       +   G
Sbjct: 1036 IMGSVQVQVVASFQGEVLPGAKNKVRGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLG 1095

Query: 259  GKSRV-------------GKSRGGGDKKLRRQGQNAALAGAKRRGAAT------------ 293
             +++V               +R     ++    Q   L GA+ +  +T            
Sbjct: 1096 ARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAEDEAY 1155

Query: 294  ----AGEKPAAKGRGGRGPKSLGGQNPR-----WGRGGKKPRRRGQK------------- 331
                A   P ++  GG G ++     P      W   G +     ++             
Sbjct: 1156 AKPEAEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQTMDGDW 1215

Query: 332  ------ATKAAAAGTKRGGGGQQKAAVV---GVKSRKKQRRRGKKPRRQKASAAGAKSRG 382
                  A     A      G   KA ++    V   +   +     R +     G  +R 
Sbjct: 1216 ENSVSWADDENEASIGSWSGASDKAGIIRSWAVACDETSVKSWAGARAENVVGIGTWARA 1275

Query: 383  GGDKKG-------LREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAA 435
            G    G         E    GD      W     +A     A        +    G  + 
Sbjct: 1276 GEQASGGLWAGGQTSEGTWAGDKASGGAWTGAENQASGGSWALAGNQAIGELWAAGQASD 1335

Query: 436  KSRGGKSRSG---------GGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKS 486
             S  G   SG         GG       Q +    A AGA +             AG  S
Sbjct: 1336 GSWPGGQASGVSWVGEEAIGGSWTGAENQASEGSWAGAGAGNMSSVSYWAGVVDQAGGGS 1395

Query: 487  RGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSR 546
              G      G +  R   +A   G  A A G  S G         ++ G + +  G    
Sbjct: 1396 WAGTSDQSGGGSKPRFEDQASGEGSWAGAGGQASGG---------SMLGPEDQSSGRSWA 1446

Query: 547  QRQKAVAAGA-------TSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQK 599
                  + G+       +S G       + GGG+KPR   QT       G G        
Sbjct: 1447 DTADQASGGSRLGHVDQSSGGAWAGTLDQSGGGSKPRFENQTTEEGSWAGAG-------- 1498

Query: 600  AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
                    ++G G K        G   +S  + W       +     +  G   + +GG 
Sbjct: 1499 -------GQAGGGSK-------VGPEDQSSGRSWANSGDQISG---GFLVGIVDQANGGS 1541

Query: 660  QPRWQKPAAAGSE---SSAAAAVGQEAEARKK-----PRRRRAKSRGDGGQNAAVGINPW 711
                  PA+ G +       +  G  A+AR++         R +S GD         + W
Sbjct: 1542 WTGAGHPASVGPKPIFEDQVSGRGSWADAREQVVGDSRLGLRDQSSGDSWAGTGDQASGW 1601

Query: 712  --QRRGKKPRLGKSRGGGGAKSRGS-GGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRR 768
                 G +   G   G  G    GS  G  ++ S G+    G + + S    G GA  + 
Sbjct: 1602 FCVCPGSQTNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGS-CWTGAGAVDQA 1660

Query: 769  GGGAKSRSGEKAVTAG---GQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
            GG +K    ++A+  G   G      GG +P       G G    AGG+
Sbjct: 1661 GGCSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQSSGIGSWGVAGGQ 1709



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 200/878 (22%), Positives = 289/878 (32%), Gaps = 164/878 (18%)

Query: 70   KARLRGQKGAV----AGKEAR-QHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR 124
            K ++RG    +    AG + + Q   ++ G      RG    KA A   K   G G   +
Sbjct: 581  KIKVRGNVNTMPKEGAGVDMKAQGMAQSQGEALPNTRGKARGKAKA---KCKTGPGMDMK 637

Query: 125  RRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG--------EKPQK 176
               Q  A  G K P       A   S+  G G   A + AG K+             PQ 
Sbjct: 638  TCTQPQA--GVKTPA-----EALLDSRVDGRGNPNATSKAGTKADQRVCGQPLVVANPQG 690

Query: 177  AAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF-GKTRGGRRKKHRRPKPAAGGA 235
             A  GAK++    P        G+      Q EA   F G+   G + K +        A
Sbjct: 691  EALPGAKNKVKGNPHTVLKVGAGEGTTDSAQPEAVVSFQGEALLGTKNKVKGNPNVVLKA 750

Query: 236  KSRRGGGKKPQKQRRRGQKAAT---------GGKSRVGKSRGGGDK------KLRRQGQN 280
            +   G     Q Q     K            G  + V K+  G D       ++    Q 
Sbjct: 751  EVGEGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKAGAGTDTTGSVQPQIVANSQG 810

Query: 281  AALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGR--------GGKKPRRRGQKA 332
              L GAK +        P      G GP +     P+           G K   +    A
Sbjct: 811  EVLPGAKNKIRGN----PTTVPNSGVGPYTTDSARPQAVANSQGEVLPGAKNKVKANLNA 866

Query: 333  TKAAAAGTKRGGGGQQKAAVVG---VKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGL 389
               A AG    G  Q +A            K + RG      KA A G  +RG    + +
Sbjct: 867  VSKAEAGMGATGSVQPQAVANSHCETLPGAKNKVRGNWNAVSKAGA-GMDTRGSAQPQAV 925

Query: 390  REAKRRGD---GRKKPRWQNPRRRAQKAPAAKPRGGGSK------KPRRRGPKAAKSRGG 440
              A  +G+   G K     NP     KA A +   G ++        R   P A     G
Sbjct: 926  --ANSQGEVLPGAKNKVKGNPNV-VSKAGAREDTVGSTQPQVLASSQRETLPGARNKVKG 982

Query: 441  KSR--SGGGKKPRRRGQKARQKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLK----- 492
             S   S  G +    G    Q  A +  E+  G + + +  ++A      G G+      
Sbjct: 983  NSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGAGIMGSVQV 1042

Query: 493  ----SHSGKNLWRRGQKAEAAGEKATA----AGAKSRGRKQPRR----QKPAVAGAKSRV 540
                S  G+ L   G K +  G         AGA + G  QP+     Q   + GA+++V
Sbjct: 1043 QVVASFQGEVL--PGAKNKVRGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLGARNKV 1100

Query: 541  GGSKSRQRQKAVAAGATSHGG------GGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQ 594
             G+     +    AG T H        G   ++  G  +K     +  A A+     D+ 
Sbjct: 1101 KGNTIAVPKAGTGAG-TRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAE-----DEA 1154

Query: 595  PGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR-GQKDAAAAEKAWATGA-- 651
                +A A  T    G  G +A R+    T        W   G +D  AAE+ W      
Sbjct: 1155 YAKPEAEAMPTSESEGGSGTQACRK----TQPNIHDYYWNGIGVEDWIAAER-WIKFRFQ 1209

Query: 652  TSRGSGGKQPRW---QKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGI 708
            T  G       W   +  A+ GS S A+   G              KS         VGI
Sbjct: 1210 TMDGDWENSVSWADDENEASIGSWSGASDKAGIIRSWAVACDETSVKSWAGARAENVVGI 1269

Query: 709  NPWQRRGKKPRLGKSRGG-------GGAKSRGSG--GAKSRGSGGAKSRSGKKA------ 753
              W R G++   G   GG        G K+ G    GA+++ SGG+ + +G +A      
Sbjct: 1270 GTWARAGEQASGGLWAGGQTSEGTWAGDKASGGAWTGAENQASGGSWALAGNQAIGELWA 1329

Query: 754  ---AASKSHGGG------------------GAKRRRGGGAKSRSGEKAVT---------- 782
               A+  S  GG                  GA+ +   G+ + +G   ++          
Sbjct: 1330 AGQASDGSWPGGQASGVSWVGEEAIGGSWTGAENQASEGSWAGAGAGNMSSVSYWAGVVD 1389

Query: 783  -AGGQKAA-----AAGGKKPPRVKSRGGRGQKAAAGGK 814
             AGG   A     + GG KP       G G  A AGG+
Sbjct: 1390 QAGGGSWAGTSDQSGGGSKPRFEDQASGEGSWAGAGGQ 1427



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 194/890 (21%), Positives = 309/890 (34%), Gaps = 161/890 (18%)

Query: 39   APALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR-QHWQKAAGAG- 96
            A   + A  G KI   G+     +  A    +A ++ Q   VA K+A      +  G G 
Sbjct: 418  AKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACIQPQ--TVAKKQAEVTSGARVDGRGN 475

Query: 97   ---------GAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQ-----KAAATGSKKPRWRA 142
                     GA+ R   + +A A+ T +      K + RG      KA A  + +   + 
Sbjct: 476  TNVISKAITGADMRAAAQPQAVAS-THAEAMSDAKVKNRGNPNAMTKAGAKANLRANSQV 534

Query: 143  QKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRG-----AKS 197
            +    A  K+RG     A    G       +PQ  A+  A + S  K + RG      K 
Sbjct: 535  EALPDARDKSRGNPNVMAKVGDGTDMLSCTQPQLVASVQADTLSDGKIKVRGNVNTMPKE 594

Query: 198  RGDEDKK--GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSR-----RGGGKKPQKQRR 250
                D K  G  +        TRG  R K +       G   +     + G K P +   
Sbjct: 595  GAGVDMKAQGMAQSQGEALPNTRGKARGKAKAKCKTGPGMDMKTCTQPQAGVKTPAEALL 654

Query: 251  RGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG------RG 304
              +    G  +   K+    D+++  Q     L  A  +G A  G K   KG      + 
Sbjct: 655  DSRVDGRGNPNATSKAGTKADQRVCGQ----PLVVANPQGEALPGAKNKVKGNPHTVLKV 710

Query: 305  GRGPKSLGGQNPR-----WGRG--GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
            G G  +     P       G    G K + +G       A   + G G    A +  + S
Sbjct: 711  GAGEGTTDSAQPEAVVSFQGEALLGTKNKVKGNPNVVLKA---EVGEGAMGTAQLQIMAS 767

Query: 358  RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK--RRGDGRKKPRWQNPRRRAQKAP 415
             K +     K + +  S A +K+  G D  G  + +      G   P  +N   + +  P
Sbjct: 768  SKGEALLDSKNKVKGNSNAVSKAGAGTDTTGSVQPQIVANSQGEVLPGAKN---KIRGNP 824

Query: 416  AAKPRGG-GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG---- 470
               P  G G        P+A  +  G+   G   K +       +  AEAG  + G    
Sbjct: 825  TTVPNSGVGPYTTDSARPQAVANSQGEVLPGAKNKVKANLNAVSK--AEAGMGATGSVQP 882

Query: 471  ---------------DKKQGRQKA---SAAGTKSRGG----GLKSHSGKNLWRRGQKAEA 508
                           +K +G   A   + AG  +RG      + +  G+ L     K + 
Sbjct: 883  QAVANSHCETLPGAKNKVRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKG 942

Query: 509  AGEKATAAGAK--SRGRKQPR----RQKPAVAGAKSRVGG-----SKSRQRQKAVAAGAT 557
                 + AGA+  + G  QP+     Q+  + GA+++V G     SK+  R+  + +   
Sbjct: 943  NPNVVSKAGAREDTVGSTQPQVLASSQRETLPGARNKVKGNSNVVSKAGAREDTMGSAQP 1002

Query: 558  SHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG----------------GDKQPGWQKAA 601
                   +++  G  NK +  G + A +K   G                G+  PG +   
Sbjct: 1003 QVVANSQRETLPGARNKVK--GNSNAISKAEAGAGIMGSVQVQVVASFQGEVLPGAKNKV 1060

Query: 602  AG----VTKSRSG-DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
             G    V K+ +G D    A  Q  A + +++      + + +  A  KA  TGA +R S
Sbjct: 1061 RGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLGARNKVKGNTIAVPKA-GTGAGTRHS 1119

Query: 657  ------GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRR---RAKSRGDGGQNA--- 704
                   G Q      A   S S++ A    E EA  KP       ++S G  G  A   
Sbjct: 1120 AQPQIVAGSQGETLPGARDKSMSTSEAEATAEDEAYAKPEAEAMPTSESEGGSGTQACRK 1179

Query: 705  -----------AVGINPW--QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK 751
                        +G+  W    R  K R  ++  G    S      ++  S G+ S +  
Sbjct: 1180 TQPNIHDYYWNGIGVEDWIAAERWIKFRF-QTMDGDWENSVSWADDENEASIGSWSGASD 1238

Query: 752  KA------------AASKSHGGGGAKRRRGGGAKSRSGEKA---VTAGGQ 786
            KA             + KS  G  A+   G G  +R+GE+A   + AGGQ
Sbjct: 1239 KAGIIRSWAVACDETSVKSWAGARAENVVGIGTWARAGEQASGGLWAGGQ 1288


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 122/590 (20%), Positives = 218/590 (36%), Gaps = 104/590 (17%)

Query: 167 KSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDE---DKKGRQREAKSRFGKTRGGRRK 223
           + +G  +  K A    + R+ +K R R  + R  E   D+K  +R  K R  K    R +
Sbjct: 38  RRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRER 97

Query: 224 KHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
           +  R K         R   ++ ++ R++ ++  T  +   G+ R    ++ R + ++A  
Sbjct: 98  QRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE- 156

Query: 284 AGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRG 343
              K R   T  E+     R  +  K    +  R  R  ++  R+ +K  K     ++RG
Sbjct: 157 ---KERERQTDRERQRQTERNRQ--KEREREKNRQER--RERERQREKENKTEDRHSERG 209

Query: 344 GGGQQKAAVVGVKSRKKQ------------RRRGKKPRRQKASAAGAKSRGGGDKKGLRE 391
              +++        RK+Q            R R K+  R++AS    ++    +++  R+
Sbjct: 210 RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASER--ETERDKERERERD 267

Query: 392 AKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPR 451
             R  D R+K R +   R+ Q+    + R    K+ R+R  +  + R  K      ++  
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRR-TERDRETERKRERQRERERERERNRKRE----RERE 322

Query: 452 RRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE 511
           R  ++ RQ+  E   E   ++K+ RQ         + G      G+    R ++ E   +
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDRERNRQTG----REGRRQAERERERERERD 378

Query: 512 KATAAGAKSRGRKQPR-RQKPAVAGAKSRVGGS----KSRQRQKAVAAGATSHGGGGNKQ 566
           + +A   + R R + R RQK      +    G     K R+R+K   +      G   ++
Sbjct: 379 RQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438

Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
            +G   ++ RQ  + A   + R      P  + A +GV +S                   
Sbjct: 439 QKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQS---------------DPNR 483

Query: 627 KSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
            +R   W+   +D  AA   +               W +PA A             +  R
Sbjct: 484 PTRGIRWKSSPEDPKAASTRFP--------------WGRPAKA-------------SRGR 516

Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGG 736
              RRR                  W+     PRLG+ RG GG   R SGG
Sbjct: 517 VAGRRR------------------WE-----PRLGEKRGQGGEGRRPSGG 543



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 93/523 (17%), Positives = 201/523 (38%), Gaps = 66/523 (12%)

Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
           RK  RR +K      K+ R R ++      + R    ++       +++  E+ ++    
Sbjct: 77  RKRERRREKDRHR--KRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETERE 134

Query: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
           G + R  +   +R  + + D +K+  ++  + R  +T   R+K+  R K      + RR 
Sbjct: 135 GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK----NRQERRE 190

Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
             ++ +K+ +   + +  G+ R  +     + + +RQ         ++R      EK A 
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRER---DRQRKTEREREKQAE 247

Query: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360
           + R                R  ++ R R +   +                       R+K
Sbjct: 248 RERASERETE---------RDKERERERDRDRDR---------------------DRRQK 277

Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
           +R R    +RQ+ +    ++    +++  RE +R  + +++   +  R R ++    + R
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDR 337

Query: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQK---AAEAGAESRGDKKQGRQ 477
               ++ R+R  +  + R  ++   G ++  R  ++ R++   +A    E   D+ + RQ
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQ 397

Query: 478 KASAAGT-KSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPR-RQKPAVAG 535
           K     T K R G  +  + K   R   +    G +      K +GR++ R RQ    AG
Sbjct: 398 KERERQTEKDRDG--QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455

Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRG----GGGNKPR------QWGQTAAAA 585
            + +          +   +G        N+ +RG         P+       WG+ A A+
Sbjct: 456 RQRKRSTLYVNPPPRTARSGVVQ--SDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKAS 513

Query: 586 KTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKS 628
           + R  G ++  W+    G  + + G+G     R+ + G G ++
Sbjct: 514 RGRVAGRRR--WE-PRLGEKRGQGGEG-----RRPSGGFGTEN 548



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 109/616 (17%), Positives = 227/616 (36%), Gaps = 85/616 (13%)

Query: 186 SGKKPRRRGA-----KSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
           S + PRRRG       + GD+ ++ RQ+E + R  K +  R    +R +        +R 
Sbjct: 33  SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRD 92

Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
             ++ Q+ R + ++  T             D++  RQ +       K R      E+   
Sbjct: 93  RHRERQRDREKERERQT-------------DRERDRQRE-------KERNRQKERERETE 132

Query: 301 K-GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRK 359
           + G  GR  ++ G +     R  +K R R  +  +     T+R    +++      + R+
Sbjct: 133 REGERGRDRQTDGQRERERQRDAEKERER--QTDRERQRQTERNRQKEREREKNRQERRE 190

Query: 360 KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
           ++R+R K+ + +   +   + R    +      ++R   R++ R +   R  +K  A + 
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQ-AERE 249

Query: 420 RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKA 479
           R    +  R +  +  + R  + R    K+  R+  + RQ+  E   E+   +++ R++ 
Sbjct: 250 RASERETERDKERERERDRD-RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308

Query: 480 SAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSR 539
                       +  + K    R ++ E   ++ T      R R++ R +K      K +
Sbjct: 309 RE----------RERNRKRERERERERERERQRET-----ERDREKERERK-----RKRQ 348

Query: 540 VGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQK 599
               + R RQ          G  G +Q+      + R+  + +A  +     D+    QK
Sbjct: 349 TEMDRERNRQT---------GREGRRQAERER-ERERERDRQSAREREERERDRDRDRQK 398

Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
                T+ +  DG ++  +Q+      +S +   R  +++     +      T R +G +
Sbjct: 399 ERERQTE-KDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQ 457

Query: 660 QPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPR 719
           + R          ++ +  V  +++  +  R  R KS  +  + A+    PW R  K   
Sbjct: 458 RKRSTLYVNPPPRTARSGVV--QSDPNRPTRGIRWKSSPEDPKAASTRF-PWGRPAKA-- 512

Query: 720 LGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEK 779
                              SRG    + R   +    +  GG G +   G G ++   + 
Sbjct: 513 -------------------SRGRVAGRRRWEPRLGEKRGQGGEGRRPSGGFGTENPLSQA 553

Query: 780 AVTAGGQKAAAAGGKK 795
                G +     GK+
Sbjct: 554 PSVFPGPRYTPGDGKR 569



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 49/204 (24%), Positives = 84/204 (41%), Gaps = 15/204 (7%)

Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGS---KNRGAGAQKAAAAAGVKSQGGEKPQ 175
           R R+  R G++ A    ++ R R ++SA       ++R    QK       K + G++  
Sbjct: 355 RNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRET 414

Query: 176 KAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK---HRRPKPAA 232
           +      K R  ++ R RG   R  E +KGR+R+ + +  +  G +RK+   +  P P  
Sbjct: 415 EKQREREKDRESERGRERG---REREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471

Query: 233 GGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAA 292
             +   +    +P +  R  + +    K+   +   G   K  R      +AG +RR   
Sbjct: 472 ARSGVVQSDPNRPTRGIR-WKSSPEDPKAASTRFPWGRPAKASR----GRVAG-RRRWEP 525

Query: 293 TAGEKPAAKGRGGRGPKSLGGQNP 316
             GEK    G G R     G +NP
Sbjct: 526 RLGEKRGQGGEGRRPSGGFGTENP 549



 Score = 37.0 bits (84), Expect = 0.074
 Identities = 86/469 (18%), Positives = 167/469 (35%), Gaps = 46/469 (9%)

Query: 361 QRRRGKK--PRRQKASAAGAKSRGGGDKKGLR--EAKRRGDGRKKPRWQNPRRRAQKAPA 416
           +RR G +  PRR+    A  K   G D++  R  E +RR + R+  R +  R+R ++   
Sbjct: 28  RRRPGSQESPRRRGLGQAH-KDADGDDRERNRQKERERRREKRQTER-ETDRKRERRREK 85

Query: 417 AKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGR 476
            + R    K+ R R  +  + +  + ++   +  +R  ++ RQK  E   E  G++ + R
Sbjct: 86  DRHR----KRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141

Query: 477 QKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGA 536
           Q       + +    K    +    R ++ E   +K        + R++  RQ+      
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT 201

Query: 537 KSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPG 596
           + R    + R+R++       +      ++ R     + RQ        KT    +KQ  
Sbjct: 202 EDR-HSERGRERERERETETET------ERKRQTDRERDRQ-------RKTEREREKQAE 247

Query: 597 WQKAAAGVT-----KSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA 651
            ++A+   T     + R  D  +   R++        RK+  RR ++D     K      
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQ-RRTERDRETERKRERQRE 306

Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRR-----RAKSRGDGGQNAAV 706
             R     + R ++                  + R++ R+R     R ++R  G +    
Sbjct: 307 RERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQ 366

Query: 707 GINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSG-----------KKAAA 755
                +R  ++ R          + R     K R     K R G           K   +
Sbjct: 367 AERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRES 426

Query: 756 SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG 804
            +    G  + ++ G  + R  +    AG Q+  +     PP   +R G
Sbjct: 427 ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSG 475


>gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1297

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 212/852 (24%), Positives = 282/852 (33%), Gaps = 141/852 (16%)

Query: 4    RGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQK 63
            RGH        R G G  LG   A  P+ + A+        AA GV+ L    + L  + 
Sbjct: 263  RGH-----GGDRRGGGEGLGTVAAAAPLRVCADDLG-----AAVGVRGLAGLQEGLDSRH 312

Query: 64   AAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKA-------------AA 110
                 +    R + G      A   W +  G      RGGG  K+              A
Sbjct: 313  LLHEAQPLHARRRAG-----HAGSFWLR--GGRDRLRRGGGHTKSHLGVVTIVPGRRGRA 365

Query: 111  AGTKSLGGRGRKPR--RRGQKAAATGSKKPRWRAQKSAAAGSKN-RGAGAQKAAAAAGVK 167
            AG +  GGRGR+ +  RRG++ A  G  K          AG+   R       A  AG  
Sbjct: 366  AGGQERGGRGRRRQQGRRGRRQAGPGLAK----VDVDVLAGALGLRWQWVLVHAGQAGQP 421

Query: 168  SQGGEK-PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF-GKTRGGRRKKH 225
             QG  + P + AA   ++      R  G +       +G   E   R  G  RG R +  
Sbjct: 422  LQGQARGPHRPAALAQEALRAAAARPHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTL 481

Query: 226  RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
                   GGA            +       ATG    VG   G G      QG  AA   
Sbjct: 482  LLQDAPHGGAH-----------EHVLVAVPATG----VGGLVGAG------QGAVAAAGN 520

Query: 286  AKRR---GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKP--RRRGQKATKAAA-AG 339
            A  R   G    GE+    GRG RG +  GG       G +       GQ  T   A   
Sbjct: 521  APERLPAGVQGCGEEV---GRGARGDRVAGGHVEVVPVGQQLAICMLHGQLGTAPHAHVP 577

Query: 340  TKRGGGGQQKAAVVGVKSRKK---QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
            T  GG    +A +V   +R++   +RR G  PRR +    G    GGG   GL++    G
Sbjct: 578  TVLGGALGGRAGLVAAPARRECPARRRGGCWPRRPRRRHGGG---GGGGGPGLQDLLGGG 634

Query: 397  DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
                             APAA        +  R G  A         + G          
Sbjct: 635  HAG------GAHGHVVVAPAAAAPTAREGRAGRHGHVAVVC---PQVAAGAPVGADLDVS 685

Query: 457  ARQKAAEAGAESRGDKKQGRQKASAAGTKS---------RGGGLKSHSGKNLWRRGQKAE 507
                    G   RG +  GR +A+ A  +          RG G   H     WR      
Sbjct: 686  VVLWVGVVGHLGRG-RGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGP 744

Query: 508  AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS 567
             A       G   R         PAV  A    G        +  AA A S G G  +  
Sbjct: 745  LAQPSVQVLGRVPRD--------PAVGAATVAQGPVHGHVPVELTAAAAVS-GRGRLRDG 795

Query: 568  RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAK 627
             G   +   +  Q A A      G +        AGV     G GG  A    A     +
Sbjct: 796  LGRVASVAAEGAQVAWAGAVLVQGHE--------AGVAGGARG-GGAAAGGPLAGAVVQR 846

Query: 628  SRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARK 687
             R++  R G++   A   A A G    G+GG   R +     G      AAV Q A  R+
Sbjct: 847  MRQRRVRAGRRRVGARAVA-AAGRQGAGAGGGGRRVRHGHGHG------AAVLQRAPCRQ 899

Query: 688  KPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKS-RGSGGAKSRGSGGAK 746
            +     A +       AA G+   Q R  +P      G  GA S R   GA+ R      
Sbjct: 900  QRHLAPAAAAA-----AAQGVRAAQGRAHRP------GAQGAPSHRHRPGARGR------ 942

Query: 747  SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
             RS ++AA + +   GGA   R    + R G +AV A     A   G +  +V      G
Sbjct: 943  -RSRRRAAVALA---GGAHPARAALGRRRGGGQAVGARAAHQARLAGGQVDQVVVAARAG 998

Query: 807  QKAAAGGKKPLR 818
                  G++P R
Sbjct: 999  DADGVRGRRPRR 1010



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 87/328 (26%), Positives = 118/328 (35%), Gaps = 26/328 (7%)

Query: 68   GKKARLRGQKGAVAGKEARQHWQKAA-----GAGGAENR---GGGEQKAAAAGTKSLGGR 119
            G   R RG   A A + AR+           G GG  +R   G   Q        S+   
Sbjct: 694  GHLGRGRGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGPLAQPSVQVL 753

Query: 120  GRKPRRRGQKAA--ATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
            GR PR     AA  A G        + +AAA    RG         A V ++G +     
Sbjct: 754  GRVPRDPAVGAATVAQGPVHGHVPVELTAAAAVSGRGRLRDGLGRVASVAAEGAQVAWAG 813

Query: 178  AAAGAKSRSGKKPRRRGAKSRGDEDKKG----RQREAKSRFGKTRGGRRKKHRRPKPAAG 233
            A       +G     RG  +       G    R R+ + R G+ R G R      +  AG
Sbjct: 814  AVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAG 873

Query: 234  GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAAT 293
                  GGG++ +     G         R  +           QG  AA   A R GA  
Sbjct: 874  AG----GGGRRVRHGHGHGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAAQGRAHRPGAQG 929

Query: 294  AGE---KPAAKGRGGRGPKSL---GGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
            A     +P A+GR  R   ++   GG +P     G+  RR G +A  A AA   R  GGQ
Sbjct: 930  APSHRHRPGARGRRSRRRAAVALAGGAHPARAALGR--RRGGGQAVGARAAHQARLAGGQ 987

Query: 348  QKAAVVGVKSRKKQRRRGKKPRRQKASA 375
                VV  ++      RG++PRR   +A
Sbjct: 988  VDQVVVAARAGDADGVRGRRPRRLALTA 1015



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 200/848 (23%), Positives = 279/848 (32%), Gaps = 140/848 (16%)

Query: 44  AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
           A AAG     S D+       A G   +RLR ++     +  R  WQ     G   +  G
Sbjct: 120 APAAGAADAHSADETPEASGPAPGALVSRLRKRRR----RRLRLGWQP----GLLPHVDG 171

Query: 104 GEQKAAAAGTKSLGGRGRK--PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
              +      + L   GR   PR   Q    T   +P  R Q+       + G G   A 
Sbjct: 172 DVVETILEAGRGLSAHGRSTAPRTTDQAPGLTRGPRPALRCQRGRRL-QLSWGGGRLVAP 230

Query: 162 AAAGVKSQGGEKPQKAAAAGAK---------SRSGKKPRRRGAKSRGDEDKKGRQREAKS 212
           + A   +     P++    G +          R     RR G +  G        R    
Sbjct: 231 SRADTHAALAAFPERDIFHGGRVVALGVVGEGRGHGGDRRGGGEGLGTVAAAAPLRVCAD 290

Query: 213 RFGKTRGGRRKKHRRPKPAAGGAKSRRGGGK-KPQKQRRRGQKAAT----GGKSRVGKSR 267
             G   G R     +      G  SR    + +P   RRR   A +    GG+ R+   R
Sbjct: 291 DLGAAVGVRGLAGLQE-----GLDSRHLLHEAQPLHARRRAGHAGSFWLRGGRDRL--RR 343

Query: 268 GGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRR 327
           GGG  K    G    + G  RRG A  G++     RGGRG +   G+  R        R+
Sbjct: 344 GGGHTK-SHLGVVTIVPG--RRGRAAGGQE-----RGGRGRRRQQGRRGR--------RQ 387

Query: 328 RGQKATK------AAAAGTKRGG----GGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAG 377
            G    K      A A G +        GQ    + G ++R   R         +A+AA 
Sbjct: 388 AGPGLAKVDVDVLAGALGLRWQWVLVHAGQAGQPLQG-QARGPHRPAALAQEALRAAAAR 446

Query: 378 AKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKS 437
              R     +GLR A   G GR    W+  R +      A P GG  +      P  A  
Sbjct: 447 PHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTLLLQDA-PHGGAHEHVLVAVP--ATG 503

Query: 438 RGGKSRSG------GGKKPRRRGQKARQKAAEAGAESRGDKKQG---------RQKASAA 482
            GG   +G       G  P R     +    E G  +RGD+  G         +Q A   
Sbjct: 504 VGGLVGAGQGAVAAAGNAPERLPAGVQGCGEEVGRGARGDRVAGGHVEVVPVGQQLAICM 563

Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
                G    +H    L        A G +A    A +R R+ P R++          GG
Sbjct: 564 LHGQLGTAPHAHVPTVL------GGALGGRAGLVAAPAR-RECPARRR----------GG 606

Query: 543 SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQT-----AAAAKTRGGGDKQPGW 597
              R+ ++    G    GGG   Q   GGG+     G       AAA   R G   + G 
Sbjct: 607 CWPRRPRRRHGGGGG--GGGPGLQDLLGGGHAGGAHGHVVVAPAAAAPTAREGRAGRHGH 664

Query: 598 -----QKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA- 651
                 + AAG       D     W       G   R +   R +   AA E     G  
Sbjct: 665 VAVVCPQVAAGAPVGADLDVSVVLW---VGVVGHLGRGRGAGRAEAARAAREGGPHQGVF 721

Query: 652 TSRGSGG----KQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVG 707
             RG GG      P W+          +   +G+         R  A       Q    G
Sbjct: 722 IQRGRGGLGHRPLPGWRGQGVGPLAQPSVQVLGRVP-------RDPAVGAATVAQGPVHG 774

Query: 708 INPWQRRGKKPRLGKSR---GGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGA 764
             P +        G+ R   G G   S  + GA+   +G    +  +   A  + GGG A
Sbjct: 775 HVPVELTAAAAVSGRGRLRDGLGRVASVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAA 834

Query: 765 -------------KRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
                        ++RR    + R G +AV A G++ A AGG      + R G G  AA 
Sbjct: 835 AGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAGAGGGGR---RVRHGHGHGAAV 891

Query: 812 GGKKPLRR 819
             + P R+
Sbjct: 892 LQRAPCRQ 899



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 97/390 (24%), Positives = 133/390 (34%), Gaps = 79/390 (20%)

Query: 94   GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQ---KSAAAGS 150
            G  G   RG G  +A AA     GG  +    +  +        P WR Q     A    
Sbjct: 691  GVVGHLGRGRGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGPLAQPSV 750

Query: 151  KNRGAGAQKAAAAAGVKSQG---GEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQ 207
            +  G   +  A  A   +QG   G  P +  AA A S                   +GR 
Sbjct: 751  QVLGRVPRDPAVGAATVAQGPVHGHVPVELTAAAAVSG------------------RGRL 792

Query: 208  REAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR 267
            R+   R                 AA GA+    G    Q     G +A   G +R G + 
Sbjct: 793  RDGLGRVASV-------------AAEGAQVAWAGAVLVQ-----GHEAGVAGGARGGGAA 834

Query: 268  GGGDKK---LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGG-- 322
             GG      ++R  Q    AG +R GA       AA GR G G    GG+  R G G   
Sbjct: 835  AGGPLAGAVVQRMRQRRVRAGRRRVGARAV----AAAGRQGAGAGG-GGRRVRHGHGHGA 889

Query: 323  --------KKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS-RKKQRRRGKKPRRQKA 373
                    ++ R     A  AAA G +   G   +    G  S R +   RG++ RR+ A
Sbjct: 890  AVLQRAPCRQQRHLAPAAAAAAAQGVRAAQGRAHRPGAQGAPSHRHRPGARGRRSRRRAA 949

Query: 374  SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
             A      GG         +RRG G+           A+ A  A+  GG      +    
Sbjct: 950  VALA----GGAHPARAALGRRRGGGQAV--------GARAAHQARLAGG------QVDQV 991

Query: 434  AAKSRGGKSRSGGGKKPRRRGQKARQKAAE 463
               +R G +    G++PRR    AR +  E
Sbjct: 992  VVAARAGDADGVRGRRPRRLALTARPELEE 1021


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.125    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,764,842
Number of Sequences: 37866
Number of extensions: 2105706
Number of successful extensions: 39594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 451
Number of HSP's successfully gapped in prelim test: 1413
Number of HSP's that attempted gapping in prelim test: 15224
Number of HSP's gapped (non-prelim): 13641
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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