Guide to the Human Genome
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Search of human proteins with 239757282

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239757282 PREDICTED: similar to Fc fragment of IgG binding
protein [Homo sapiens]
         (1403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239757282 PREDICTED: similar to Fc fragment of IgG binding pr...  3034   0.0  
gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo ...  2930   0.0  
gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]       2930   0.0  
gi|239757286 PREDICTED: similar to Fc fragment of IgG binding pr...   753   0.0  
gi|134268640 tectorin alpha precursor [Homo sapiens]                  731   0.0  
gi|16554449 zonadhesin isoform 3 [Homo sapiens]                       686   0.0  
gi|27881494 zonadhesin isoform 6 [Homo sapiens]                       686   0.0  
gi|239757284 PREDICTED: similar to Fc fragment of IgG binding pr...   546   e-155
gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens]    362   2e-99
gi|134031945 SCO-spondin [Homo sapiens]                               357   4e-98
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]      355   1e-97
gi|161019170 mucin 5AC [Homo sapiens]                                 346   8e-95
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]        308   2e-83
gi|116284392 mucin 2 precursor [Homo sapiens]                         304   3e-82
gi|239755901 PREDICTED: chromosome 12 open reading frame 64 [Hom...   303   6e-82
gi|239750386 PREDICTED: chromosome 12 open reading frame 64 [Hom...   303   6e-82
gi|239744688 PREDICTED: hypothetical protein LOC283310 [Homo sap...   303   6e-82
gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]             297   4e-80
gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]             297   4e-80
gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]             297   4e-80
gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]             297   4e-80
gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]             297   4e-80
gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]             297   4e-80
gi|151301154 mucin 6, gastric [Homo sapiens]                          281   3e-75
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]   208   3e-53
gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]             205   3e-52
gi|37693519 BMP-binding endothelial regulator precursor protein ...   185   3e-46
gi|239750277 PREDICTED: hypothetical protein XP_002347351 [Homo ...   144   6e-34
gi|239744587 PREDICTED: hypothetical protein XP_002343203 [Homo ...   144   6e-34
gi|239755776 PREDICTED: similar to Mucin-19 [Homo sapiens]            134   8e-31

>gi|239757282 PREDICTED: similar to Fc fragment of IgG binding protein
            [Homo sapiens]
          Length = 1403

 Score = 3034 bits (7867), Expect = 0.0
 Identities = 1403/1403 (100%), Positives = 1403/1403 (100%)

Query: 1    MRTLECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKE 60
            MRTLECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKE
Sbjct: 1    MRTLECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKE 60

Query: 61   QGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVT 120
            QGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVT
Sbjct: 61   QGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVT 120

Query: 121  TKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGA 180
            TKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGA
Sbjct: 121  TKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGA 180

Query: 181  SKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIP 240
            SKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIP
Sbjct: 181  SKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIP 240

Query: 241  IWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPP 300
            IWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPP
Sbjct: 241  IWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPP 300

Query: 301  ESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV 360
            ESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV
Sbjct: 301  ESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV 360

Query: 361  CGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEA 420
            CGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEA
Sbjct: 361  CGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEA 420

Query: 421  GSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDP 480
            GSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDP
Sbjct: 421  GSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDP 480

Query: 481  HYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYN 540
            HYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYN
Sbjct: 481  HYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYN 540

Query: 541  HSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLR 600
            HSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLR
Sbjct: 541  HSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLR 600

Query: 601  VPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQE 660
            VPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQE
Sbjct: 601  VPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQE 660

Query: 661  SFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ 720
            SFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ
Sbjct: 661  SFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ 720

Query: 721  AAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFV 780
            AAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFV
Sbjct: 721  AAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFV 780

Query: 781  LSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECR 840
            LSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECR
Sbjct: 781  LSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECR 840

Query: 841  LEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLE 900
            LEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLE
Sbjct: 841  LEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLE 900

Query: 901  KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGL 960
            KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGL
Sbjct: 901  KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGL 960

Query: 961  RLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGS 1020
            RLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGS
Sbjct: 961  RLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGS 1020

Query: 1021 SKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL 1080
            SKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL
Sbjct: 1021 SKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL 1080

Query: 1081 CAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAA 1140
            CAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAA
Sbjct: 1081 CAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAA 1140

Query: 1141 LSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC 1200
            LSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC
Sbjct: 1141 LSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC 1200

Query: 1201 SSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYE 1260
            SSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYE
Sbjct: 1201 SSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYE 1260

Query: 1261 LSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDL 1320
            LSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDL
Sbjct: 1261 LSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDL 1320

Query: 1321 PAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQT 1380
            PAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQT
Sbjct: 1321 PAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQT 1380

Query: 1381 NDWHDSQEKPAMEKWRAQDFSPW 1403
            NDWHDSQEKPAMEKWRAQDFSPW
Sbjct: 1381 NDWHDSQEKPAMEKWRAQDFSPW 1403


>gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo
            sapiens]
          Length = 3003

 Score = 2930 bits (7596), Expect = 0.0
 Identities = 1357/1373 (98%), Positives = 1361/1373 (99%), Gaps = 2/1373 (0%)

Query: 33   QPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 92
            QP   +L  ++ DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD
Sbjct: 1631 QPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 1690

Query: 93   FQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
            FQGTCNYVLATTGC GVSTQGLTPFTVTTKN+NRGNPAVSYVRVVTVAALGTNISIHKDE
Sbjct: 1691 FQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDE 1750

Query: 153  IGKVRV--NGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH 210
            IGKVRV  NGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH
Sbjct: 1751 IGKVRVCVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH 1810

Query: 211  GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDR 270
            GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDR
Sbjct: 1811 GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDR 1870

Query: 271  LEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVA 330
            LEQYEGPGFCGPLA GTGGPFTTCHAHVPPESFFKGCVLDVCMGGGD DILCKALASYVA
Sbjct: 1871 LEQYEGPGFCGPLASGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVA 1930

Query: 331  ACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQ 390
            ACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQ
Sbjct: 1931 ACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQ 1990

Query: 391  CDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASC 450
            CDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASC
Sbjct: 1991 CDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASC 2050

Query: 451  GLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLG 510
            GLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLG
Sbjct: 2051 GLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLG 2110

Query: 511  AENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLL 570
            AENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLL
Sbjct: 2111 AENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLL 2170

Query: 571  HAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK 630
            HAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK
Sbjct: 2171 HAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK 2230

Query: 631  PAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQY 690
            PAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQY
Sbjct: 2231 PAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQY 2290

Query: 691  FQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGD 750
            FQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGD
Sbjct: 2291 FQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGD 2350

Query: 751  SCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG 810
            SCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG
Sbjct: 2351 SCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG 2410

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR
Sbjct: 2411 PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 2470

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD 930
            VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD
Sbjct: 2471 VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD 2530

Query: 931  GEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFN 990
            GEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFN
Sbjct: 2531 GEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFN 2590

Query: 991  GNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 1050
            GNWSDDFVLPNGSAASSVETFGAAWR PGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC
Sbjct: 2591 GNWSDDFVLPNGSAASSVETFGAAWRAPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 2650

Query: 1051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
            GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP
Sbjct: 2651 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 2710

Query: 1111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIP 1170
            WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIP
Sbjct: 2711 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIP 2770

Query: 1171 VQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWA 1230
            VQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWA
Sbjct: 2771 VQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWA 2830

Query: 1231 TRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEA 1290
            TRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEA
Sbjct: 2831 TRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEA 2890

Query: 1291 VGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWL 1350
            VGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWL
Sbjct: 2891 VGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWL 2950

Query: 1351 GANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSPW 1403
            GANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSPW
Sbjct: 2951 GANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSPW 3003



 Score = 1024 bits (2648), Expect = 0.0
 Identities = 554/1435 (38%), Positives = 776/1435 (54%), Gaps = 90/1435 (6%)

Query: 41   LLSP--DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +LSP    C G+ C   + C+  GG+  C+    A C   GDPHY +FDGR++D  GTC+
Sbjct: 436  VLSPVEPSCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCS 495

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRV 158
            Y +     L      L  F+V  KNE+RG+  VSYV +VTV A   ++S+ + E+G V V
Sbjct: 496  YTMVE---LCSEDDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLV 552

Query: 159  NGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCG 218
            +   + LPVS+++GR+ V Q   +A++   FGL V+YDW+ ++ ++LP+ +   VCGLCG
Sbjct: 553  DNQRSRLPVSLSEGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCG 612

Query: 219  NMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPG 278
            N + +P +D + P+G LAP    +  SW+    D LC D C+ +CP C   + + YEG  
Sbjct: 613  NYNGDPADDFLTPDGALAPDAVEFASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDR 672

Query: 279  FCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVV 338
             CG L     GPF  CH  + P  F + CV D+C+ GG+   LC+ L++Y  AC   G+ 
Sbjct: 673  LCGMLTK-LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGIS 731

Query: 339  IEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG-PCVEGCQCDAGFVL 397
            + DWR+   C ++CP NS YE+CGP CP SC   A    P+ C G PCVEGC C  GFV 
Sbjct: 732  VGDWRSPANCPLSCPANSRYELCGPACPTSCNGAA---APSNCSGRPCVEGCVCLPGFVA 788

Query: 398  SADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPA-SCGLGEVC 456
            S   CVP ++ CGC   G     G E WAD  C + C C      + C    SC  GE C
Sbjct: 789  SGGACVPASS-CGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERC 847

Query: 457  GLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTV 516
             +  +G  GC P     CQ  GDPHYV+ DG RFDF GTC YLL   C G       F V
Sbjct: 848  SV-QNGLLGCYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSC-GQNAALPAFRV 905

Query: 517  TVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLS 575
             V NEHRGSQ VSYTR+V ++     + +   +P ++ VD V   LPFQ  D  +     
Sbjct: 906  LVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQ 965

Query: 576  GADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG-- 633
            G D VV T  GL++ +D ++ V  +VP++YA +LCGLCGN+N DPADDL   GG  A   
Sbjct: 966  GRDAVVRTDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANA 1025

Query: 634  ------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPP 687
                  WQ     GCG      CP   +   Q+     + CG+++   GP   CH  + P
Sbjct: 1026 LAFGNSWQEETRPGCGATEPGDCPKLDSLVAQQ-LQSKNECGILADPKGPFRECHSKLDP 1084

Query: 688  AQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYEL 747
                + C+ D C + G  G LC A+ATY AACQAAGA +  WR  + CPL CP HSHYE 
Sbjct: 1085 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1144

Query: 748  CGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVF 807
            C   CP+SC  L  P GC S C EGCVCD GF LSG++C+P+  CGC+H G Y+P G+ F
Sbjct: 1145 CSYGCPLSCGDLPVPGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTF 1204

Query: 808  YPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITL 867
            YPGP C+  C C  GG V+C E ++CGPHE C+   G   C A G   C A+G  HY T 
Sbjct: 1205 YPGPGCDSLCHCQEGGLVSC-ESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTF 1263

Query: 868  DGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLA 922
            DGR +D  G+C YVLAQ C  +PG   F+++ E  A G+      + + V VA   + L 
Sbjct: 1264 DGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLE 1323

Query: 923  QGQ-QVTVDGEAVALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
            Q Q +VTV+G  + LPV  A G++R +  G ++V++T  GLR+ +D   ++ +++P  + 
Sbjct: 1324 QRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYY 1383

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWR--VPGSSKGCGEGCGPQGCPVCL 1037
             ++CGLCGN+NG+  DDF  PNGS A +   FG +W   VP S       C P G   C+
Sbjct: 1384 QQMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPC-PPGSEDCI 1442

Query: 1038 AEETAP------YESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLC 1091
                 P      Y+  E CG L +P GP ++C  ++ P    + C++DLC   G+ + LC
Sbjct: 1443 PSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILC 1502

Query: 1092 RSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRC 1151
             ++ AY +ACQAAG  V+PWRT++FCP+ CP +SHY +C  TC   C+ALS    C   C
Sbjct: 1503 SNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGC 1562

Query: 1152 FEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAA 1211
             EGC+CD  FL +   C+P+Q CGC HNG Y     ++L  +C ++C+C +  G+ CQ  
Sbjct: 1563 AEGCQCDSGFLYNGQACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKGMVCQEH 1622

Query: 1212 GCPPGRVCEVKAEARNC-------------------WATRGLCVLSVGA--------NLT 1244
             C PG+VC+      +C                      +G+C+ +  A        +  
Sbjct: 1623 SCKPGQVCQPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYH 1682

Query: 1245 TFDGARGATTSPGVYELSSR-CPGL--QNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDG 1301
            +FDG +        Y L++  CPG+  Q   P + V  + Q  +    AV  V +     
Sbjct: 1683 SFDGRKFDFQGTCNYVLATTGCPGVSTQGLTP-FTVTTKNQ--NRGNPAVSYVRVVTVAA 1739

Query: 1302 MVT-LTPNKG------VWVNGLRVDLPAEKL-ASVSVSRTPDGSLLVRQKAGVQVWLGAN 1353
            + T ++ +K       V VNG+   LP       +SV++    +LLV    G+QV    N
Sbjct: 1740 LGTNISIHKDEIGKVRVCVNGVLTALPVSVADGRISVAQGASKALLVAD-FGLQVSYDWN 1798

Query: 1354 GKVAVIVSNDHAGKLCGACGNFDGDQTND--WHDSQEKPAME----KWRAQDFSP 1402
             +V V + + + G +CG CGN D +  ND  + +    P++      WRA  + P
Sbjct: 1799 WRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDP 1853



 Score =  892 bits (2306), Expect = 0.0
 Identities = 520/1420 (36%), Positives = 726/1420 (51%), Gaps = 129/1420 (9%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C   +C P E C+  GG   C+    +TC   GDPHY +FDGR+FDF GTC YVLA T C
Sbjct: 1224 CESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQT-C 1282

Query: 107  LGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALP 166
               +  GL  F V  +N   GN  VS  RV+TV      + + + +  KV VNGV   LP
Sbjct: 1283 --GTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQ-WKVTVNGVDMKLP 1339

Query: 167  VSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNN 226
            V +A+G+I  +Q  S  ++  DFGL+V+YD  + V VT+P +Y+  +CGLCGN + +P +
Sbjct: 1340 VVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKD 1399

Query: 227  DQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT----------CPEDRLEQYEG 276
            D   PNG+ A +   +G SW     D  C       CP           CP +  ++Y+ 
Sbjct: 1400 DFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPT--PCPPGSEDCIPSHKCPPELEKKYQK 1457

Query: 277  PGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAG 336
              FCG L+  TG P ++CH  V P+   K C+ D+C+GGG+  ILC  + +YV+ACQAAG
Sbjct: 1458 EEFCGLLSSPTG-PLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAG 1516

Query: 337  VVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFV 396
              +E WR +  C + CP NSHYE+C   C   C +   L+ P  C+  C EGCQCD+GF+
Sbjct: 1517 GHVEPWRTETFCPMECPPNSHYELCADTCSLGCSA---LSAPPQCQDGCAEGCQCDSGFL 1573

Query: 397  LSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCG------------------- 437
             +   CVP+   CGC+ NG Y+E       D  C Q C C                    
Sbjct: 1574 YNGQACVPIQQ-CGCYHNGVYYEPEQTVLIDN-CRQQCTCHAGKGMVCQEHSCKPGQVCQ 1631

Query: 438  PGGGSLVCTP------ASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFD 491
            P GG L C         +C   E C     GQ  C P   A C  WGDPHY + DG +FD
Sbjct: 1632 PSGGILSCVTKDPCHGVTCRPQETC-KEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 1690

Query: 492  FQGTCEYLLSAP-CHG-PPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARW 549
            FQGTC Y+L+   C G    G   FTVT  N++RG+ AVSY R VT+     ++++    
Sbjct: 1691 FQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDE 1750

Query: 550  PRKLQ--VDGVFVALPFQL-DSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYA 606
              K++  V+GV  ALP  + D  +      +  ++    GL +++D +  V + +P++Y 
Sbjct: 1751 IGKVRVCVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH 1810

Query: 607  ASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQG-CGECVSKPCPSPCTPE 657
             ++CGLCGN +++P +D     G  A         W+  G    C +     CP+ C  +
Sbjct: 1811 GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT-CPED 1869

Query: 658  QQESFGGPDACG-VISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYV 716
            + E + GP  CG + S T GP   CH  VPP  +F+GC+LD C   G    LC A+A+YV
Sbjct: 1870 RLEQYEGPGFCGPLASGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYV 1929

Query: 717  AACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPS---LSAPEGCESACREGC 773
            AACQAAG  + +WR    C + CP +SHYE+CG  CP SCPS   L+ P  CE  C EGC
Sbjct: 1930 AACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGC 1989

Query: 774  VCDAGFVLSGDTCVPVGQ-CGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAA 832
             CDAGFVLS D CVP+   CGC  +G Y+  G  F+    C + C CGPGG       A+
Sbjct: 1990 QCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPAS 2049

Query: 833  CGPHEEC-RLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKP- 890
            CG  E C  L  G   C       C A G  HY+TLDG  +D  G+C Y+L+  CH  P 
Sbjct: 2050 CGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPL 2109

Query: 891  GDEDFSIVLEKNAAGDLQ-------RLLVTVAGQVVSLAQGQQVTVDGEAVALPVAV-GR 942
            G E+F++ +     G           L +      +S    +++ VDG  VALP  +   
Sbjct: 2110 GAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSL 2169

Query: 943  VRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNG 1002
            +     G ++V+ TT GL L FDGD+ + + +P+ +   LCGLCGN+N + +DD     G
Sbjct: 2170 LHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGG 2229

Query: 1003 SAASSVETFGAAWRVPGSSKGCGEGCGPQGCP-VCLAEETAPYESNEACGQLRNPQGPFA 1061
                      A W+V G ++GCGE C  + CP  C  E+   +   +ACG +    GP A
Sbjct: 2230 KP--------AGWQV-GGAQGCGE-CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLA 2279

Query: 1062 TCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             C  ++ P++YF+ C+ D C  +G    LC ++A Y AACQAAG  +  WR   FCPL C
Sbjct: 2280 PCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQC 2339

Query: 1122 PAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGR 1181
            PAHSHY +C  +C  SC +LS   GC + C EGC CD  F+LS   C+PV  CGC H+GR
Sbjct: 2340 PAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGR 2399

Query: 1182 YLPVNSSLLTS-DCSERCSCSSSSGLTCQ-AAGCPPGRVCEVKAEARNCWATR-GLCVLS 1238
            Y P+        +C  RC C     +TCQ  A C P   C ++   + C AT  G C+ +
Sbjct: 2400 YYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLAN 2459

Query: 1239 VGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGK----------- 1287
             G +  T DG         VY+L   C                Q+CH K           
Sbjct: 2460 GGIHYITLDGR--------VYDLHGSCS-----------YVLAQVCHPKPGDEDFSIVLE 2500

Query: 1288 TEAVGQVH---IFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKA 1344
              A G +    +     +V+L   + V V+G  V LP   +A   V  T +G  +V Q  
Sbjct: 2501 KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALP---VAVGRVRVTAEGRNMVLQTT 2557

Query: 1345 -GVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             G+++    +  + + + +   G+LCG CGNF+G+ ++D+
Sbjct: 2558 KGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDF 2597


>gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]
          Length = 5405

 Score = 2930 bits (7595), Expect = 0.0
 Identities = 1355/1370 (98%), Positives = 1360/1370 (99%)

Query: 33   QPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 92
            QP   +L  ++ DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD
Sbjct: 4033 QPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 4092

Query: 93   FQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
            FQGTCNYVLATTGC GVSTQGLTPFTVTTKN+NRGNPAVSYVRVVTVAALGTNISIHKDE
Sbjct: 4093 FQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDE 4152

Query: 153  IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 212
            IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA
Sbjct: 4153 IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 4212

Query: 213  VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 272
            VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE
Sbjct: 4213 VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 4272

Query: 273  QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAAC 332
            QYEGPGFCGPL+ GTGGPFTTCHAHVPPESFFKGCVLDVCMGGGD DILCKALASYVAAC
Sbjct: 4273 QYEGPGFCGPLSSGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAAC 4332

Query: 333  QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 392
            QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD
Sbjct: 4333 QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 4392

Query: 393  AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 452
            AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL
Sbjct: 4393 AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 4452

Query: 453  GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE 512
            GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE
Sbjct: 4453 GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE 4512

Query: 513  NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHA 572
            NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHA
Sbjct: 4513 NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHA 4572

Query: 573  HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA 632
            HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA
Sbjct: 4573 HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA 4632

Query: 633  GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 692
            GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ
Sbjct: 4633 GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 4692

Query: 693  GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC 752
            GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC
Sbjct: 4693 GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC 4752

Query: 753  PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE 812
            PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE
Sbjct: 4753 PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE 4812

Query: 813  CERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVY 872
            CERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVY
Sbjct: 4813 CERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVY 4872

Query: 873  DLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGE 932
            DLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGE
Sbjct: 4873 DLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGE 4932

Query: 933  AVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGN 992
            AVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGN
Sbjct: 4933 AVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGN 4992

Query: 993  WSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQ 1052
            WSDDFVLPNGSAASSVETFGAAWR PGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQ
Sbjct: 4993 WSDDFVLPNGSAASSVETFGAAWRAPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQ 5052

Query: 1053 LRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWR 1112
            LRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWR
Sbjct: 5053 LRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWR 5112

Query: 1113 TDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQ 1172
            TDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQ
Sbjct: 5113 TDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQ 5172

Query: 1173 DCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATR 1232
            DCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATR
Sbjct: 5173 DCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATR 5232

Query: 1233 GLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVG 1292
            GLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVG
Sbjct: 5233 GLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVG 5292

Query: 1293 QVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGA 1352
            QVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGA
Sbjct: 5293 QVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGA 5352

Query: 1353 NGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSP 1402
            NGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSP
Sbjct: 5353 NGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSP 5402



 Score = 2019 bits (5231), Expect = 0.0
 Identities = 977/1428 (68%), Positives = 1092/1428 (76%), Gaps = 64/1428 (4%)

Query: 33   QPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 92
            QP   +L  ++ DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD
Sbjct: 2832 QPSGGILSCVNKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 2891

Query: 93   FQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
            FQGTCNYVLATTGC GVSTQGLTPFTVTTKN+NRGNPAVSYVRVVTVAALGTNISIHKDE
Sbjct: 2892 FQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDE 2951

Query: 153  IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 212
            IGKVRVNGVLTALPVSVADGRISV QGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA
Sbjct: 2952 IGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 3011

Query: 213  VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 272
            VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE
Sbjct: 3012 VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 3071

Query: 273  QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAAC 332
            QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGD DILCKALASYVAAC
Sbjct: 3072 QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAAC 3131

Query: 333  QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 392
            QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD
Sbjct: 3132 QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 3191

Query: 393  AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 452
            AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL
Sbjct: 3192 AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 3251

Query: 453  GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE 512
            GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE
Sbjct: 3252 GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE 3311

Query: 513  NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHA 572
            NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFV LPFQLDSLLHA
Sbjct: 3312 NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHA 3371

Query: 573  HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA 632
            HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYA SLCGLCGNYNQDPADDLKAVGGKPA
Sbjct: 3372 HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPA 3431

Query: 633  GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 692
            GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ
Sbjct: 3432 GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 3491

Query: 693  GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC 752
            GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL EWRRPDFCP QCPAHSHYELCGDSC
Sbjct: 3492 GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSC 3551

Query: 753  PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE 812
            P SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD RYYPLG+ FYPGP 
Sbjct: 3552 PGSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPG 3611

Query: 813  CERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVY 872
            C+  C C  GG V+C E ++CGPHE CR   G   C A G   C A+G  HY T DG  +
Sbjct: 3612 CDSLCRCREGGEVSC-EPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGHRF 3670

Query: 873  DLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLAQGQ-Q 926
            D  G+C YVLAQ C  +PG   F+++ E  A G+      + + V VA   + L Q Q +
Sbjct: 3671 DFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWK 3730

Query: 927  VTVDGEAVALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCG 984
            VTV+G  + LPV  A G++R +  G ++V++T  GLR+ +D   ++ +++P  +   +CG
Sbjct: 3731 VTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQLMCG 3790

Query: 985  LCGNFNGNWSDDFVLPNGSAASSVETFGAAWR--VPGSSKGCGEGCGPQGCPVCLAEETA 1042
            LCGN+NG+  DDF  PNGS A +   FG +W   VP S       C P G   C+  +  
Sbjct: 3791 LCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTC-PPGSAGCIPSDKC 3849

Query: 1043 P------YESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAA 1096
            P      Y+  E CG L +P GP ++C  ++ P    + C++DLC   G+ + LC ++ A
Sbjct: 3850 PPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHA 3909

Query: 1097 YTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
            Y +ACQAAG  V+PWR ++FCP+ CP +SHY +C  TC   C+ALS    C   C EGC+
Sbjct: 3910 YVSACQAAGGHVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQ 3969

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            CD  FL +   C+P+Q CGC HNG Y     ++L  +C ++C+C     + CQ   C PG
Sbjct: 3970 CDSGFLYNGQACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHVGKVVVCQEHSCKPG 4029

Query: 1217 RVCEVKAEARNC-------------------WATRGLCVLSVGA--------NLTTFDGA 1249
            +VC+      +C                      +G+C+ +  A        +  +FDG 
Sbjct: 4030 QVCQPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGR 4089

Query: 1250 RGATTSPGVYELSSR-CPGL--QNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVT-L 1305
            +        Y L++  CPG+  Q   P + V  + Q  +    AV  V +     + T +
Sbjct: 4090 KFDFQGTCNYVLATTGCPGVSTQGLTP-FTVTTKNQ--NRGNPAVSYVRVVTVAALGTNI 4146

Query: 1306 TPNKG----VWVNGLRVDLPAEKL-ASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIV 1360
            + +K     V VNG+   LP       +SV++    +LLV    G+QV    N +V V +
Sbjct: 4147 SIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVAD-FGLQVSYDWNWRVDVTL 4205

Query: 1361 SNDHAGKLCGACGNFDGDQTND--WHDSQEKPAME----KWRAQDFSP 1402
             + + G +CG CGN D +  ND  + +    P++      WRA  + P
Sbjct: 4206 PSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDP 4253



 Score = 2018 bits (5229), Expect = 0.0
 Identities = 976/1428 (68%), Positives = 1092/1428 (76%), Gaps = 64/1428 (4%)

Query: 33   QPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 92
            QP   +L  ++ DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD
Sbjct: 1631 QPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFD 1690

Query: 93   FQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
            FQGTCNYVLATTGC GVSTQGLTPFTVTTKN+NRGNPAVSYVRVVTVAALGTNISIHKDE
Sbjct: 1691 FQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDE 1750

Query: 153  IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 212
            IGKVRVNGVLTALPVSVADGRISV QGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA
Sbjct: 1751 IGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGA 1810

Query: 213  VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 272
            VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE
Sbjct: 1811 VCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE 1870

Query: 273  QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAAC 332
            QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGD DILCKALASYVAAC
Sbjct: 1871 QYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAAC 1930

Query: 333  QAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 392
            QAAGVVIEDWRAQVGCEITCPENSHYEVCG PCPASCPSPAPLTTPAVCEGPCVEGCQCD
Sbjct: 1931 QAAGVVIEDWRAQVGCEITCPENSHYEVCGSPCPASCPSPAPLTTPAVCEGPCVEGCQCD 1990

Query: 393  AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 452
            AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL
Sbjct: 1991 AGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 2050

Query: 453  GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAE 512
            GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRF+FQGTCEYLLSAPCHGPPLGAE
Sbjct: 2051 GEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAE 2110

Query: 513  NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHA 572
            NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFV LPFQLDSLLHA
Sbjct: 2111 NFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHA 2170

Query: 573  HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA 632
            HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYA SLCGLCGNYNQDPADDLKAVGGKPA
Sbjct: 2171 HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPA 2230

Query: 633  GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 692
            GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ
Sbjct: 2231 GWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQ 2290

Query: 693  GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC 752
            GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL EWRRPDFCP QCPAHSHYELCGDSC
Sbjct: 2291 GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSC 2350

Query: 753  PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE 812
            P SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD RYYPLG+ FYPGP 
Sbjct: 2351 PGSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPG 2410

Query: 813  CERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVY 872
            C+  C C  GG V+C E ++CGPHE CR   G   C A G   C A+G  HY T DGR +
Sbjct: 2411 CDSLCRCREGGEVSC-EPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGRRF 2469

Query: 873  DLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLAQGQ-Q 926
            D  G+C YVLAQ C  +PG   F+++ E  A G+      + + V VA   + L Q Q +
Sbjct: 2470 DFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWK 2529

Query: 927  VTVDGEAVALPVAV--GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCG 984
            VTV+G  + LPV +  G++R +  G ++V++T  GLR+ +D   ++ +++P  +   +CG
Sbjct: 2530 VTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQLMCG 2589

Query: 985  LCGNFNGNWSDDFVLPNGSAASSVETFGAAWR--VPGSSKGCGEGCGPQGCPVCLAEETA 1042
            LCGN+NG+  DDF  PNGS A +   FG +W   VP S       C P G   C+  E  
Sbjct: 2590 LCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTC-PPGSEGCIPSEEC 2648

Query: 1043 P------YESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAA 1096
            P      Y+  E CG L +P GP ++C  ++ P    + C++DLC   G+ + LC ++ A
Sbjct: 2649 PPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHA 2708

Query: 1097 YTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
            Y +ACQAAG  V+PWR ++FCP+ CP +SHY +C  TC   C+ALS    C   C EGC+
Sbjct: 2709 YVSACQAAGGQVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQ 2768

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            CD  FL +   C+P+Q CGC HNG Y     ++L  +C ++C+C     + CQ   C PG
Sbjct: 2769 CDSGFLYNGQACVPIQQCGCYHNGAYYEPEQTVLIDNCRQQCTCHVGKVVVCQEHSCKPG 2828

Query: 1217 RVCEVKAEARNC-------------------WATRGLCVLSVGA--------NLTTFDGA 1249
            +VC+      +C                      +G+C+ +  A        +  +FDG 
Sbjct: 2829 QVCQPSGGILSCVNKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGR 2888

Query: 1250 RGATTSPGVYELSSR-CPGL--QNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVT-L 1305
            +        Y L++  CPG+  Q   P + V  + Q  +    AV  V +     + T +
Sbjct: 2889 KFDFQGTCNYVLATTGCPGVSTQGLTP-FTVTTKNQ--NRGNPAVSYVRVVTVAALGTNI 2945

Query: 1306 TPNKG----VWVNGLRVDLPAEKL-ASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIV 1360
            + +K     V VNG+   LP       +SV++    +LLV    G+QV    N +V V +
Sbjct: 2946 SIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVAD-FGLQVSYDWNWRVDVTL 3004

Query: 1361 SNDHAGKLCGACGNFDGDQTND--WHDSQEKPAME----KWRAQDFSP 1402
             + + G +CG CGN D +  ND  + +    P++      WRA  + P
Sbjct: 3005 PSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDP 3052



 Score = 1025 bits (2649), Expect = 0.0
 Identities = 553/1433 (38%), Positives = 776/1433 (54%), Gaps = 88/1433 (6%)

Query: 41   LLSP--DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +LSP    C G+ C   + C+  GG+  C+    A C   GDPHY +FDGR++D  GTC+
Sbjct: 436  VLSPVEPSCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCS 495

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRV 158
            Y +     L      L  F+V  KNE+RG+  VSYV +VTV A   ++S+ + E+G V V
Sbjct: 496  YTMVE---LCSEDDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLV 552

Query: 159  NGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCG 218
            +   + LPVS+++GR+ V Q   +A++   FGL V+YDW+ ++ ++LP+ +   VCGLCG
Sbjct: 553  DNQRSRLPVSLSEGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCG 612

Query: 219  NMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPG 278
            N + +P +D + P+G LAP    +  SW+    D LC D C+ +CP C   + + YEG  
Sbjct: 613  NYNGDPADDFLTPDGALAPDAVEFASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDR 672

Query: 279  FCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVV 338
             CG L     GPF  CH  + P  F + CV D+C+ GG+   LC+ L++Y  AC   G+ 
Sbjct: 673  LCGMLTK-LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGIS 731

Query: 339  IEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG-PCVEGCQCDAGFVL 397
            + DWR+   C ++CP NS YE+CGP CP SC   A    P+ C G PCVEGC C  GFV 
Sbjct: 732  VGDWRSPANCPLSCPANSRYELCGPACPTSCNGAA---APSNCSGRPCVEGCVCLPGFVA 788

Query: 398  SADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPA-SCGLGEVC 456
            S   CVP ++ CGC   G     G E WAD  C + C C      + C    SC  GE C
Sbjct: 789  SGGACVPASS-CGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERC 847

Query: 457  GLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTV 516
             +  +G  GC P     CQ  GDPHYV+ DG RFDF GTC YLL   C G       F V
Sbjct: 848  SV-QNGLLGCYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSC-GQNAALPAFRV 905

Query: 517  TVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLS 575
             V NEHRGSQ VSYTR+V ++     + +   +P ++ VD V   LPFQ  D  +     
Sbjct: 906  LVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQ 965

Query: 576  GADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG-- 633
            G D VV T  GL++ +D ++ V  +VP++YA +LCGLCGN+N DPADDL   GG  A   
Sbjct: 966  GRDAVVRTDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANA 1025

Query: 634  ------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPP 687
                  WQ     GCG      CP   +   Q+     + CG+++   GP   CH  + P
Sbjct: 1026 LAFGNSWQEETRPGCGATEPGDCPKLDSLVAQQ-LQSKNECGILADPKGPFRECHSKLDP 1084

Query: 688  AQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYEL 747
                + C+ D C + G  G LC A+ATY AACQAAGA +  WR  + CPL CP HSHYE 
Sbjct: 1085 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1144

Query: 748  CGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVF 807
            C   CP+SC  L  P GC S C EGCVCD GF LSG++C+P+  CGC+H G Y+P G+ F
Sbjct: 1145 CSYGCPLSCGDLPVPGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTF 1204

Query: 808  YPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITL 867
            YPGP C+  C C  GG V+C E ++CGPHE C+   G   C A G   C A+G  HY T 
Sbjct: 1205 YPGPGCDSLCHCQEGGLVSC-ESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTF 1263

Query: 868  DGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLA 922
            DGR +D  G+C YVLAQ C  +PG   F+++ E  A G+      + + V VA   + L 
Sbjct: 1264 DGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLE 1323

Query: 923  QGQ-QVTVDGEAVALPVAV--GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
            Q Q +VTV+G  + LPV +  G++R +  G ++V++T  GLR+ +D   ++ +++P  + 
Sbjct: 1324 QRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYY 1383

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWR--VPGSSKGCGEGCGPQGCPVCL 1037
             ++CGLCGN+NG+  DDF  PNGS A +   FG +W   VP S       C P G   C+
Sbjct: 1384 QQMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPC-PPGSEDCI 1442

Query: 1038 AEETAP------YESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLC 1091
                 P      Y+  E CG L +P GP ++C  ++ P    + C++DLC   G+ + LC
Sbjct: 1443 PSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILC 1502

Query: 1092 RSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRC 1151
             ++ AY +ACQAAG  V+PWRT++FCP+ CP +SHY +C  TC   C+ALS    C   C
Sbjct: 1503 SNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGC 1562

Query: 1152 FEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAA 1211
             EGC+CD  FL +   C+P+Q CGC HNG Y     ++L  +C ++C+C +  G+ CQ  
Sbjct: 1563 AEGCQCDSGFLYNGQACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKGMVCQEH 1622

Query: 1212 GCPPGRVCEVKAEARNCWAT-------------------RGLCVLSVGA--------NLT 1244
             C PG+VC+      +C                      +G+C+ +  A        +  
Sbjct: 1623 SCKPGQVCQPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYH 1682

Query: 1245 TFDGARGATTSPGVYELSSR-CPGL--QNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDG 1301
            +FDG +        Y L++  CPG+  Q   P + V  + Q  +    AV  V +     
Sbjct: 1683 SFDGRKFDFQGTCNYVLATTGCPGVSTQGLTP-FTVTTKNQ--NRGNPAVSYVRVVTVAA 1739

Query: 1302 MVT-LTPNKG----VWVNGLRVDLPAEKL-ASVSVSRTPDGSLLVRQKAGVQVWLGANGK 1355
            + T ++ +K     V VNG+   LP       +SV++    +LLV    G+QV    N +
Sbjct: 1740 LGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVAD-FGLQVSYDWNWR 1798

Query: 1356 VAVIVSNDHAGKLCGACGNFDGDQTND--WHDSQEKPAME----KWRAQDFSP 1402
            V V + + + G +CG CGN D +  ND  + +    P++      WRA  + P
Sbjct: 1799 VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDP 1851



 Score =  904 bits (2336), Expect = 0.0
 Identities = 520/1407 (36%), Positives = 725/1407 (51%), Gaps = 98/1407 (6%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C   +C P ETC+  GG   C+     TC   GDPHY +FDGR+FDF GTC YVLA T C
Sbjct: 2425 CEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGRRFDFMGTCVYVLAQT-C 2483

Query: 107  LGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALP 166
               +  GL  F V  +N   GN  VS  RV+TV      + + + +  KV VNGV   LP
Sbjct: 2484 --GTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQ-WKVTVNGVDMKLP 2540

Query: 167  VSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNN 226
            V +A+G+I  +Q  S  ++  DFGL+V+YD  + V VT+P +Y+  +CGLCGN + +P +
Sbjct: 2541 VVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKD 2600

Query: 227  DQVFPNGTLAPSIPIWGGSWRAPGWD------PLCWDECRGSCPT--CPEDRLEQYEGPG 278
            D   PNG+ A +   +G SW     D      P C     G  P+  CP +  ++Y+   
Sbjct: 2601 DFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCPPGSEGCIPSEECPPELEKKYQKEE 2660

Query: 279  FCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVV 338
            FCG L+  TG P ++CH  V P+   K C+ D+C+GGG+  ILC  + +YV+ACQAAG  
Sbjct: 2661 FCGLLSSPTG-PLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGQ 2719

Query: 339  IEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLS 398
            +E WR +  C + CP+NSHYE+C   C   C +   L+ P  C   C EGCQCD+GF+ +
Sbjct: 2720 VEPWRNETFCPMECPQNSHYELCADTCSLGCSA---LSAPLQCPDGCAEGCQCDSGFLYN 2776

Query: 399  ADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVC-- 456
               CVP+   CGC+ NG Y+E       D  C Q C C  G   +VC   SC  G+VC  
Sbjct: 2777 GQACVPIQQ-CGCYHNGAYYEPEQTVLIDN-CRQQCTCHVGK-VVVCQEHSCKPGQVCQP 2833

Query: 457  --GLLP---------------------SGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQ 493
              G+L                       GQ  C P   A C  WGDPHY + DG +FDFQ
Sbjct: 2834 SGGILSCVNKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQ 2893

Query: 494  GTCEYLLSAP-CHGPPL-GAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPR 551
            GTC Y+L+   C G    G   FTVT  N++RG+ AVSY R VT+     ++++      
Sbjct: 2894 GTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIG 2953

Query: 552  KLQVDGVFVALPFQL-DSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLC 610
            K++V+GV  ALP  + D  +      +  ++    GL +++D +  V + +P++Y  ++C
Sbjct: 2954 KVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVC 3013

Query: 611  GLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQG-CGECVSKPCPSPCTPEQQES 661
            GLCGN +++P +D     G  A         W+  G    C +     CP+ C  ++ E 
Sbjct: 3014 GLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT-CPEDRLEQ 3072

Query: 662  FGGPDACGVIS-ATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ 720
            + GP  CG ++  T GP   CH  VPP  +F+GC+LD C   G    LC A+A+YVAACQ
Sbjct: 3073 YEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQ 3132

Query: 721  AAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPS---LSAPEGCESACREGCVCDA 777
            AAG  + +WR    C + CP +SHYE+CG  CP SCPS   L+ P  CE  C EGC CDA
Sbjct: 3133 AAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDA 3192

Query: 778  GFVLSGDTCVPVGQ-CGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPH 836
            GFVLS D CVP+   CGC  +G Y+  G  F+    C + C CGPGG       A+CG  
Sbjct: 3193 GFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLG 3252

Query: 837  EECRL-EDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKP-GDED 894
            E C L   G   C       C A G  HY+TLDG  +D  G+C Y+L+  CH  P G E+
Sbjct: 3253 EVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAEN 3312

Query: 895  FSIVLEKNAAGDLQ-------RLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRV-RVT 946
            F++ +     G           L +      +S    +++ VDG  V LP  +  +    
Sbjct: 3313 FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAH 3372

Query: 947  AEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAAS 1006
              G ++V+ TT GL L FDGD+ + + +P+ + G LCGLCGN+N + +DD     G  A 
Sbjct: 3373 LSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPAG 3432

Query: 1007 SVETFGAAWRVPGSSKGCGEGCGPQGCPV-CLAEETAPYESNEACGQLRNPQGPFATCQA 1065
                    W+V G ++GCGE C  + CP  C  E+   +   +ACG +    GP A C  
Sbjct: 3433 --------WQV-GGAQGCGE-CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHG 3482

Query: 1066 VLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHS 1125
            ++ P++YF+ C+ D C  +G    LC ++A Y AACQAAG  ++ WR   FCP  CPAHS
Sbjct: 3483 LVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHS 3542

Query: 1126 HYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPV 1185
            HY +C  +C GSC +LS   GC + C EGC CD  F+LS   C+PV  CGC H+ RY P+
Sbjct: 3543 HYELCGDSCPGSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPL 3602

Query: 1186 NSSLLTSD-CSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGL-CVLSVGANL 1243
              +      C   C C     ++C+ + C P   C     +  C A     C  S   + 
Sbjct: 3603 GQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHY 3662

Query: 1244 TTFDGARGATTSPGVYELSSRC---PGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQD 1300
            TTFDG R       VY L+  C   PGL         V +  +  G         I  Q 
Sbjct: 3663 TTFDGHRFDFMGTCVYVLAQTCGTRPGLHRF-----AVLQENVAWGNGRVSVTRVITVQV 3717

Query: 1301 GMVTLTPNKGVW---VNGLRVDLPAEKLASVSVSRTPDGS-LLVRQKAGVQVWLGANGKV 1356
               TL   +  W   VNG+ + LP   LA+  +  +  GS +++    G++V       V
Sbjct: 3718 ANFTLRLEQRQWKVTVNGVDMKLPVV-LANGQIRASQHGSDVVIETDFGLRVAYDLVYYV 3776

Query: 1357 AVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             V V  ++   +CG CGN++GD  +D+
Sbjct: 3777 RVTVPGNYYQLMCGLCGNYNGDPKDDF 3803



 Score =  889 bits (2296), Expect = 0.0
 Identities = 530/1425 (37%), Positives = 729/1425 (51%), Gaps = 106/1425 (7%)

Query: 48   HGVTCRPQ------ETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVL 101
            H VTCR +      E C  Q G   C P+   TC   GDPHY SFDGR+FDF GTC Y+L
Sbjct: 831  HQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLL 890

Query: 102  ATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGV 161
               G  G +   L  F V  +NE+RG+  VSY R V V A G  +++ ++  G+V V+ V
Sbjct: 891  V--GSCGQNA-ALPAFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGQVLVDDV 947

Query: 162  LTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMD 221
            L  LP   ADG++ V +    A++  DFGL V+YDWN RV   +PSSY  A+CGLCGN +
Sbjct: 948  LQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFN 1007

Query: 222  RNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCG 281
             +P +D     G  A +   +G SW+     P C     G CP       +Q +    CG
Sbjct: 1008 GDPADDLALRGGGQAANALAFGNSWQEET-RPGCGATEPGDCPKLDSLVAQQLQSKNECG 1066

Query: 282  PLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIED 341
             LA   G PF  CH+ + P+   + CV D C+  G    LC ALA+Y AACQAAG  +  
Sbjct: 1067 ILADPKG-PFRECHSKLDPQGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHP 1125

Query: 342  WRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADR 401
            WR++  C ++CP +SHYE C   CP SC     L  P  C   C EGC CD GF LS + 
Sbjct: 1126 WRSEELCPLSCPPHSHYEACSYGCPLSC---GDLPVPGGCGSECHEGCVCDEGFALSGES 1182

Query: 402  CVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPS 461
            C+PL + CGC   GTYH  G  F+    C   C C  GG  + C  +SCG  E C   PS
Sbjct: 1183 CLPLAS-CGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGG-LVSCESSSCGPHEACQ--PS 1238

Query: 462  GQH-GCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVAN 520
            G   GC  V ++ CQA GDPHY T DG RFDF GTC Y+L+  C   P G   F V   N
Sbjct: 1239 GGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRP-GLHRFAVLQEN 1297

Query: 521  EHRGSQAVSYTRSVTLQIYNHSLTLSAR-WPRKLQVDGVFVALPFQL-DSLLHAHLSGAD 578
               G+  VS TR +T+Q+ N +L L  R W  K+ V+GV + LP  L +  + A   G+D
Sbjct: 1298 VAWGNGRVSVTRVITVQVANFTLRLEQRQW--KVTVNGVDMKLPVVLANGQIRASQHGSD 1355

Query: 579  VVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGG 638
            VV+ T  GL +A+D   +VR+ VP  Y   +CGLCGNYN DP DD +    KP G Q G 
Sbjct: 1356 VVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQ----KPNGSQAGN 1411

Query: 639  AQGCGECVSK-----------PCPS---------PCTPEQQESFGGPDACGVISATDGPL 678
            A   G    +           PCP           C PE ++ +   + CG++S+  GPL
Sbjct: 1412 ANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPL 1471

Query: 679  APCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQ 738
            + CH LV P    + C+ D C   G+   LC  +  YV+ACQAAG  +  WR   FCP++
Sbjct: 1472 SSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTETFCPME 1531

Query: 739  CPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDG 798
            CP +SHYELC D+C + C +LSAP  C+  C EGC CD+GF+ +G  CVP+ QCGC H+G
Sbjct: 1532 CPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNGQACVPIQQCGCYHNG 1591

Query: 799  RYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQAC------HATG 852
             YY   +       C ++C C  G  + CQE + C P + C+   G+ +C      H   
Sbjct: 1592 VYYEPEQTVLID-NCRQQCTCHAGKGMVCQEHS-CKPGQVCQPSGGILSCVTKDPCHGVT 1649

Query: 853  C------------GRCLAN--------GGIHYITLDGRVYDLHGSCSYVLAQVCHP---K 889
            C            G CL N        G  HY + DGR +D  G+C+YVLA    P    
Sbjct: 1650 CRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVST 1709

Query: 890  PGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLAQGQ--QVTVDGEAVALPVAV-- 940
             G   F++  +    G+     ++ + V   G  +S+ + +  +V V+G   ALPV+V  
Sbjct: 1710 QGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVAD 1769

Query: 941  GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLP 1000
            GR+ VT      +L    GL++ +D +  + +++PS + G +CGLCGN + N ++D V P
Sbjct: 1770 GRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFP 1829

Query: 1001 NGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLR-NPQGP 1059
            NG+ A S+  +G +WR PG    C + C    CP C  +    YE    CG L     GP
Sbjct: 1830 NGTLAPSIPIWGGSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 1888

Query: 1060 FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPL 1119
            F TC A + P  +F+ CV D+C   GD+  LC++LA+Y AACQAAGV ++ WR    C +
Sbjct: 1889 FTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEI 1948

Query: 1120 HCPAHSHYSICTRTCQGSCAALSGLTG---CTTRCFEGCECDDRFLLSQGVCIPVQD-CG 1175
             CP +SHY +C   C  SC + + LT    C   C EGC+CD  F+LS   C+P+ + CG
Sbjct: 1949 TCPENSHYEVCGSPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCG 2008

Query: 1176 CTHNGRYLPVNSSLLTSD-CSERCSCSSSSG-LTCQAAGCPPGRVCEVKAEARN-CW-AT 1231
            C  NG Y    S       CS+ C C    G L C  A C  G VC +    ++ C   +
Sbjct: 2009 CWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVS 2068

Query: 1232 RGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAV 1291
               C      +  T DG R        Y LS+ C G       + V    +  H  ++AV
Sbjct: 2069 TAECQAWGDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAENFTVTVANE--HRGSQAV 2126

Query: 1292 G---QVHIFFQDGMVTLTPN--KGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGV 1346
                 V +   +  +TL+    + + V+G+ V LP + L S+  +      ++V   +G+
Sbjct: 2127 SYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQ-LDSLLHAHLSGADVVVTTTSGL 2185

Query: 1347 QVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPA 1391
             +    +  V + V   +AG LCG CGN++ D  +D      KPA
Sbjct: 2186 SLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPA 2230



 Score =  869 bits (2246), Expect = 0.0
 Identities = 523/1422 (36%), Positives = 729/1422 (51%), Gaps = 110/1422 (7%)

Query: 47   CHGVTCRPQETCKE-QGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            C   +C   E C     GQ  C P   A C  WGDPHY + DG +F+FQGTC Y+L+   
Sbjct: 2043 CTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFNFQGTCEYLLSAP- 2101

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
            C G    G   FTVT  NE+RG+ AVSY R VT+     ++++      K++V+GV   L
Sbjct: 2102 CHGPPL-GAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTL 2160

Query: 166  PVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            P  + D  +      +  ++    GL +++D +  V + +P++Y G++CGLCGN +++P 
Sbjct: 2161 PFQL-DSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPA 2219

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT-CPEDRLEQYEGPGFCGPLA 284
            +D     G  A         W+  G    C +     CP+ C  ++ E + GP  CG ++
Sbjct: 2220 DDLKAVGGKPA--------GWQVGGAQG-CGECVSKPCPSPCTPEQQESFGGPDACGVIS 2270

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
              T GP   CH  VPP  +F+GC+LD C   G    LC A+A+YVAACQAAG  + +WR 
Sbjct: 2271 -ATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRR 2329

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVP 404
               C   CP +SHYE+CG  CP SCPS   L+ P  CE  C EGC CDAGFVLS D CVP
Sbjct: 2330 PDFCPFQCPAHSHYELCGDSCPGSCPS---LSAPEGCESACREGCVCDAGFVLSGDTCVP 2386

Query: 405  LNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQH 464
            +   CGC  +  Y+  G  F+    C   CRC  GG  + C P+SCG  E C   PSG  
Sbjct: 2387 VGQ-CGCLHDDRYYPLGQTFYPGPGCDSLCRCREGG-EVSCEPSSCGPHETCR--PSGGS 2442

Query: 465  -GCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHR 523
             GC  V +  CQA GDPHY T DG RFDF GTC Y+L+  C   P G   F V   N   
Sbjct: 2443 LGCVAVGSTTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRP-GLHRFAVLQENVAW 2501

Query: 524  GSQAVSYTRSVTLQIYNHSLTLSAR-WPRKLQVDGVFVALPFQL-DSLLHAHLSGADVVV 581
            G+  VS TR +T+Q+ N +L L  R W  K+ V+GV + LP  L +  + A   G+DVV+
Sbjct: 2502 GNGRVSVTRVITVQVANFTLRLEQRQW--KVTVNGVDMKLPVVLANGQIRASQHGSDVVI 2559

Query: 582  TTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQG 641
             T  GL +A+D   +VR+ VP  Y   +CGLCGNYN DP DD +    KP G Q G A  
Sbjct: 2560 ETDFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQ----KPNGSQAGNANE 2615

Query: 642  CGE----------CVSKP-CP---------SPCTPEQQESFGGPDACGVISATDGPLAPC 681
             G           C+  P CP           C PE ++ +   + CG++S+  GPL+ C
Sbjct: 2616 FGNSWEEVVPDSPCLPPPTCPPGSEGCIPSEECPPELEKKYQKEEFCGLLSSPTGPLSSC 2675

Query: 682  HGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPA 741
            H LV P    + C+ D C   G+   LC  +  YV+ACQAAG Q+  WR   FCP++CP 
Sbjct: 2676 HKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGQVEPWRNETFCPMECPQ 2735

Query: 742  HSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYY 801
            +SHYELC D+C + C +LSAP  C   C EGC CD+GF+ +G  CVP+ QCGC H+G YY
Sbjct: 2736 NSHYELCADTCSLGCSALSAPLQCPDGCAEGCQCDSGFLYNGQACVPIQQCGCYHNGAYY 2795

Query: 802  PLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQAC------HATGC-- 853
               +       C ++C C  G  V CQE + C P + C+   G+ +C      H   C  
Sbjct: 2796 EPEQTVLID-NCRQQCTCHVGKVVVCQEHS-CKPGQVCQPSGGILSCVNKDPCHGVTCRP 2853

Query: 854  ----------GRCLAN--------GGIHYITLDGRVYDLHGSCSYVLAQVCHP---KPGD 892
                      G CL N        G  HY + DGR +D  G+C+YVLA    P     G 
Sbjct: 2854 QETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGL 2913

Query: 893  EDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLAQGQ--QVTVDGEAVALPVAV--GRV 943
              F++  +    G+     ++ + V   G  +S+ + +  +V V+G   ALPV+V  GR+
Sbjct: 2914 TPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRI 2973

Query: 944  RVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGS 1003
             VT      +L    GL++ +D +  + +++PS + G +CGLCGN + N ++D V PNG+
Sbjct: 2974 SVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGT 3033

Query: 1004 AASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLR-NPQGPFAT 1062
             A S+  +G +WR PG    C + C    CP C  +    YE    CG L     GPF T
Sbjct: 3034 LAPSIPIWGGSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGPFTT 3092

Query: 1063 CQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCP 1122
            C A + P  +F+ CV D+C   GD+  LC++LA+Y AACQAAGV ++ WR    C + CP
Sbjct: 3093 CHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITCP 3152

Query: 1123 AHSHYSICTRTCQGSCAALSGLTG---CTTRCFEGCECDDRFLLSQGVCIPVQD-CGCTH 1178
             +SHY +C   C  SC + + LT    C   C EGC+CD  F+LS   C+P+ + CGC  
Sbjct: 3153 ENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWA 3212

Query: 1179 NGRYLPVNSSLLTSD-CSERCSCSSSSG-LTCQAAGCPPGRVCEVKAEARN-CW-ATRGL 1234
            NG Y    S       CS+ C C    G L C  A C  G VC +    ++ C   +   
Sbjct: 3213 NGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAE 3272

Query: 1235 CVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVG-- 1292
            C      +  T DG R        Y LS+ C G       + V    +  H  ++AV   
Sbjct: 3273 CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANE--HRGSQAVSYT 3330

Query: 1293 -QVHIFFQDGMVTLTPN--KGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVW 1349
              V +   +  +TL+    + + V+G+ V LP + L S+  +      ++V   +G+ + 
Sbjct: 3331 RSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQ-LDSLLHAHLSGADVVVTTTSGLSLA 3389

Query: 1350 LGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPA 1391
               +  V + V   +AG LCG CGN++ D  +D      KPA
Sbjct: 3390 FDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPA 3431


>gi|239757286 PREDICTED: similar to Fc fragment of IgG binding protein
            [Homo sapiens]
          Length = 1472

 Score =  753 bits (1945), Expect = 0.0
 Identities = 390/922 (42%), Positives = 518/922 (56%), Gaps = 33/922 (3%)

Query: 41   LLSP--DPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +LSP    C G+ C   + C+  GG+  C+    A C   GDPHY +FDGR++D  GTC+
Sbjct: 497  VLSPVEPSCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCS 556

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRV 158
            Y +     L      L  F+V  KNE+RG+  VSYV +VTV A   ++S+ + E+G V V
Sbjct: 557  YTMVE---LCSEDDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLV 613

Query: 159  NGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCG 218
            +   + LPVS+++GR+ V Q   +A++   FGL V+YDW+ ++ ++LP+ +   VCGLCG
Sbjct: 614  DNQRSRLPVSLSEGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCG 673

Query: 219  NMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPG 278
            N + +P +D + P+G LAP    +  SW+    D LC D C+ +CP C   + + YEG  
Sbjct: 674  NYNGDPADDFLTPDGALAPDAVEFASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDR 733

Query: 279  FCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVV 338
             CG L     GPF  CH  + P  F + CV D+C+ GG+   LC+ L++Y  AC   G+ 
Sbjct: 734  LCGMLTK-LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGIS 792

Query: 339  IEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG-PCVEGCQCDAGFVL 397
            + DWR+   C ++CP NS YE+CGP CP SC   A    P+ C G PCVEGC C  GFV 
Sbjct: 793  VGDWRSPANCPLSCPANSRYELCGPACPTSCNGAA---APSNCSGRPCVEGCVCLPGFVA 849

Query: 398  SADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPA-SCGLGEVC 456
            S   CVP ++ CGC   G     G E WAD  C + C C      + C    SC  GE C
Sbjct: 850  SGGACVPASS-CGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERC 908

Query: 457  GLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTV 516
             +  +G  GC P     CQ  GDPHYV+ DG RFDF GTC YLL   C G       F V
Sbjct: 909  SV-QNGLLGCYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSC-GQNAALPAFRV 966

Query: 517  TVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLS 575
             V NEHRGSQ VSYTR+V ++     + +   +P ++ VD V   LPFQ  D  +     
Sbjct: 967  LVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQ 1026

Query: 576  GADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG-- 633
            G D VV T  GL++ +D ++ V  +VP++YA +LCGLCGN+N DPADDL   GG  A   
Sbjct: 1027 GRDAVVRTDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANA 1086

Query: 634  ------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPP 687
                  WQ     GCG      CP   +   Q+     + CG+++   GP   CH  + P
Sbjct: 1087 LAFGNSWQEETRPGCGATEPGDCPKLDSLVAQQ-LQSKNECGILADPKGPFRECHSKLDP 1145

Query: 688  AQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYEL 747
                + C+ D C + G  G LC A+ATY AACQAAGA +  WR  + CPL CP HSHYE 
Sbjct: 1146 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1205

Query: 748  CGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVF 807
            C   CP+SC  L  P GC S C EGCVCD GF LSG++C+P+  CGC+H G Y+P G+ F
Sbjct: 1206 CSYGCPLSCGDLPVPGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTF 1265

Query: 808  YPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITL 867
            YPGP C+  C C  GG V+C E ++CGPHE C+   G   C A G   C A+G  HY T 
Sbjct: 1266 YPGPGCDSLCHCQEGGLVSC-ESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTF 1324

Query: 868  DGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLA 922
            DGR +D  G+C YVLAQ C  +PG   F+++ E  A G+      + + V VA   + L 
Sbjct: 1325 DGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLE 1384

Query: 923  QGQ-QVTV--DGEAVALPVAVG 941
            Q Q +VTV  DGE  A  + VG
Sbjct: 1385 QRQWKVTVRADGEQGARGLWVG 1406



 Score =  585 bits (1507), Expect = e-166
 Identities = 320/862 (37%), Positives = 433/862 (50%), Gaps = 37/862 (4%)

Query: 445  CTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPC 504
            C    C  G+ C ++  G+ GC   STA C+A GDPHY T DG R+D  GTC Y +   C
Sbjct: 505  CEGMQCAAGQRCQVV-GGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELC 563

Query: 505  HGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPF 564
                     F+V   NEHRGS+ VSY   VT++ Y+HS++L+      + VD     LP 
Sbjct: 564  SEDDT-LPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPV 622

Query: 565  QL-DSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADD 623
             L +  L  + SG   VV    GL + +D D  + L +PA +   +CGLCGNYN DPADD
Sbjct: 623  SLSEGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADD 682

Query: 624  LKAVGGKPA--------GWQVG-GAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISAT 674
                 G  A         W++  G   C +     CP+ CTP Q + + G   CG+++  
Sbjct: 683  FLTPDGALAPDAVEFASSWKLDDGDYLCEDGCQNNCPA-CTPGQAQHYEGDRLCGMLTKL 741

Query: 675  DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDF 734
            DGP A CH  + P  + + C+ D C V G    LC  ++ Y  AC   G  +G+WR P  
Sbjct: 742  DGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPAN 801

Query: 735  CPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESA-CREGCVCDAGFVLSGDTCVPVGQCG 793
            CPL CPA+S YELCG +CP SC   +AP  C    C EGCVC  GFV SG  CVP   CG
Sbjct: 802  CPLSCPANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPGFVASGGACVPASSCG 861

Query: 794  CLHDGRYYPLGEVFYPGPECERRCECGPGGH-VTCQEGAACGPHEECRLEDGVQACHATG 852
            C   G     G+  +    C+RRC C    H VTC++  +C   E C +++G+  C+   
Sbjct: 862  CTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLGCYPDR 921

Query: 853  CGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----L 907
             G C  +G  HY++ DGR +D  G+C+Y+L   C        F +++E    G       
Sbjct: 922  FGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYT 981

Query: 908  QRLLVTVAGQVVSLAQGQ--QVTVDGEAVALP--VAVGRVRVTAEGRNMVLQTTKGLRLL 963
            + + V   G  V++ +    QV VD     LP   A G+V+V  +GR+ V++T  GL + 
Sbjct: 982  RAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVT 1041

Query: 964  FDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKG 1023
            +D +A +   +PS +   LCGLCGNFNG+ +DD  L  G  A++   FG +W+   +  G
Sbjct: 1042 YDWNARVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEE-TRPG 1100

Query: 1024 CGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQ 1083
            CG    P  CP   +      +S   CG L +P+GPF  C + L P    R CVYD C  
Sbjct: 1101 CG-ATEPGDCPKLDSLVAQQLQSKNECGILADPKGPFRECHSKLDPQGAVRDCVYDRCLL 1159

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSG 1143
             G    LC +LA Y AACQAAG  V PWR++  CPL CP HSHY  C+  C  SC  L  
Sbjct: 1160 PGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEACSYGCPLSCGDLPV 1219

Query: 1144 LTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTS-DCSERCSCSS 1202
              GC + C EGC CD+ F LS   C+P+  CGC H G Y P   +      C   C C  
Sbjct: 1220 PGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQE 1279

Query: 1203 SSGLTCQAAGCPPGRVCEVKAEARNCWAT-RGLCVLSVGANLTTFDGARGATTSPGVYEL 1261
               ++C+++ C P   C+    +  C A     C  S   + TTFDG R       VY L
Sbjct: 1280 GGLVSCESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVL 1339

Query: 1262 SSRC---PG------LQNTIPW 1274
            +  C   PG      LQ  + W
Sbjct: 1340 AQTCGTRPGLHRFAVLQENVAW 1361



 Score =  323 bits (827), Expect = 9e-88
 Identities = 195/581 (33%), Positives = 282/581 (48%), Gaps = 39/581 (6%)

Query: 829  EGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHP 888
            EG  C   + C++  G   C A     C A G  HY T DGR YD+ G+CSY + ++C  
Sbjct: 506  EGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSE 565

Query: 889  KPGDEDFSIVLEKNAAGDLQRL---LVTVAG--QVVSLAQGQQ--VTVDGEAVALPVAV- 940
                  FS+  +    G  +     LVTV      VSL +G+   V VD +   LPV++ 
Sbjct: 566  DDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPVSLS 625

Query: 941  -GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVL 999
             GR+RV   G   V++   GL + +D D  L +S+P+ F+ ++CGLCGN+NG+ +DDF+ 
Sbjct: 626  EGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLT 685

Query: 1000 PNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGP 1059
            P+G+ A     F ++W++      C +GC    CP C   +   YE +  CG L    GP
Sbjct: 686  PDGALAPDAVEFASSWKLDDGDYLCEDGC-QNNCPACTPGQAQHYEGDRLCGMLTKLDGP 744

Query: 1060 FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPL 1119
            FA C   L P  +  QCVYDLC   G++  LCR L+AY  AC   G++V  WR+ + CPL
Sbjct: 745  FAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPANCPL 804

Query: 1120 HCPAHSHYSICTRTCQGSCAALSGLTGCTTR-CFEGCECDDRFLLSQGVCIPVQDCGCTH 1178
             CPA+S Y +C   C  SC   +  + C+ R C EGC C   F+ S G C+P   CGCT 
Sbjct: 805  SCPANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPGFVASGGACVPASSCGCTF 864

Query: 1179 NGRYLPVNSSLLTSD-CSERCSCSSSSG-LTCQ-AAGCPPGRVCEVKAEARNCWATR-GL 1234
             G  L     +   + C  RC+C+ ++  +TC+    CP G  C V+     C+  R G 
Sbjct: 865  QGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGT 924

Query: 1235 CVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQV 1294
            C  S   +  +FDG R        Y L   C G    +P +RV+ E +  H  ++ V   
Sbjct: 925  CQGSGDPHYVSFDGRRFDFMGTCTYLLVGSC-GQNAALPAFRVLVENE--HRGSQTVSYT 981

Query: 1295 HIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTP----DGSL---------LVR 1341
                 +        +GV V  +R + P + L    +   P    DG +         +VR
Sbjct: 982  RAVRVEA-------RGVKV-AVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVR 1033

Query: 1342 QKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTND 1382
               G+ V    N +V   V + +A  LCG CGNF+GD  +D
Sbjct: 1034 TDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFNGDPADD 1074



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 49/190 (25%), Positives = 82/190 (43%), Gaps = 23/190 (12%)

Query: 1207 TCQAAGCPPGRVCEVKAEARNCWA-TRGLCVLSVGANLTTFDGARGATTSPGVYELSSRC 1265
            +C+   C  G+ C+V      C A +  +C      + TTFDG R        Y +   C
Sbjct: 504  SCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELC 563

Query: 1266 PGLQNTIPWYRVVAEVQICHGKTEA-VGQVHIFFQDGMVTLTPNKG--VWVNGLRVDLPA 1322
                +T+P + V A+ +    +  + VG V +      V+LT  +   V V+  R  LP 
Sbjct: 564  SE-DDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLP- 621

Query: 1323 EKLASVSVSRTPDGSLLVRQKA---------GVQVWLGANGKVAVIVSNDHAGKLCGACG 1373
                 VS+S   +G L V Q           G+ V    + ++A+ +      ++CG CG
Sbjct: 622  -----VSLS---EGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCG 673

Query: 1374 NFDGDQTNDW 1383
            N++GD  +D+
Sbjct: 674  NYNGDPADDF 683


>gi|134268640 tectorin alpha precursor [Homo sapiens]
          Length = 2155

 Score =  731 bits (1888), Expect = 0.0
 Identities = 434/1374 (31%), Positives = 667/1374 (48%), Gaps = 53/1374 (3%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C   +C P E C+ +G    C     +TC ++G+PHYH+FDG  F FQG+C Y+LA   C
Sbjct: 294  CQEASCSPYEVCEPKGKFFYCSAVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQ-C 352

Query: 107  LGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALP 166
            L   T  L  F+V  KNE+R   AVS+V+ ++V   G  I I K   G+V+VN ++T+LP
Sbjct: 353  L--QTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLP 410

Query: 167  VSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNN 226
            V++  G + + Q      +  DFGL V++D      +++P SY  + CGLCGN ++NP +
Sbjct: 411  VTLDLGTVKIYQSGISTAVETDFGLLVTFDGQHYASISVPGSYINSTCGLCGNYNKNPLD 470

Query: 227  DQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPG 286
            D + P+G  A S+   G SWR    D  C   C  +C  C       Y G  +CG L   
Sbjct: 471  DFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCTQCDAATEALYFGSDYCGFLNK- 529

Query: 287  TGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV 346
            T GP   C   V P +F   CV D+C    +  +LC+A+ +Y   CQA G+ I DWR Q 
Sbjct: 530  TDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRTQT 589

Query: 347  GCEIT--CPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVP 404
            GC  T  CP  SHY VC   CP +C   + LT    C  PC EGC+C+ GFVLS  +CVP
Sbjct: 590  GCVSTVQCPSFSHYSVCTSSCPDTC---SDLTASRNCATPCTEGCECNQGFVLSTSQCVP 646

Query: 405  LNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQH 464
            L+  CGC  +G Y+  G  FWA   C+  C C  GG  + C   +CG GEVC +   G  
Sbjct: 647  LHK-CGCDFDGHYYTMGEFFWATANCTVQCLCEEGG-DVYCFNKTCGSGEVCAV-EDGYQ 703

Query: 465  GCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG 524
            GC P     C    +    T DG  + F     Y L   C   P   E   + + N+ + 
Sbjct: 704  GCFPKRETVCLLSQNQVLHTFDGASYAFPSEFSYTLLKTCPERP---EYLEIDI-NKKKP 759

Query: 525  SQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDS-LLHAHLSGADVVVTT 583
                ++ R + + + +  + +      +++++G  V LPF   S  L  + +     V +
Sbjct: 760  DAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQEVELPFFHPSGKLEIYRNKNSTTVES 819

Query: 584  TSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQ 635
               +++ +     + +R+   Y     GLCG YN + +D+     GK           W 
Sbjct: 820  KGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFYNANASDEFCLPNGKCTDNLAVFLESWT 879

Query: 636  VGGAQGCGEC--VSKPCPSPCTPEQQESFGGPDACGVIS-ATDGPLAPCHGLVPPAQYFQ 692
                   GEC  + K C +    E  + +     CG+I+  ++     CHG+V    Y++
Sbjct: 880  TFEEICNGECGDLLKACNNDS--ELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYR 937

Query: 693  GCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC 752
             CL   CQ  G+   LC +VA Y +AC+ A  ++G WR  DFCPL+CP +SH+E C  +C
Sbjct: 938  TCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSHFEEC-ITC 996

Query: 753  PVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPE 812
              +C +L+    C  +C EGC CD G+ L G  CV   +CGC  +G      E F+   +
Sbjct: 997  TETCETLTLGPICVDSCSEGCQCDEGYALLGSQCVTRSECGCNFEGHQLATNETFWVDLD 1056

Query: 813  CERRCEC-GPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRV 871
            C+  C C G    V C E   C   E C  E G+  C A     C+ +G  HY+T DG  
Sbjct: 1057 CQIFCYCSGTDNRVHC-ETIPCKDDEYCMEEGGLYYCQARTDASCIVSGYGHYLTFDGFP 1115

Query: 872  YDLHGSCSYVLAQVCHPKPGDEDFS--IVLEKNAAGD------LQRLLVTVAGQ--VVSL 921
            +D   SC  +L      +P  + F   +V  KN   D      ++++ VTV G   V+  
Sbjct: 1116 FDFQTSCPLILCTT-GSRPSSDSFPKFVVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHR 1174

Query: 922  AQGQQVTVDGEAVALPVAVG--RVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
            A    V V+ E + LP+ +G  ++ + + G ++V++T  GL++++D    L +++P   +
Sbjct: 1175 AYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSITVPRSMQ 1234

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
                GLCG +NGN  DD  +P G  ASSV  FG +W    +   C  GCG + CP C   
Sbjct: 1235 NSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFGQSWVKRDTF--CQVGCGDR-CPSCAKV 1291

Query: 1040 ETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTA 1099
            E    +  + C  + N    F+ C + ++P+ +++ C++D C   G     C  L  Y +
Sbjct: 1292 EGFS-KVQQLCSLIPNQNAAFSKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYAS 1350

Query: 1100 ACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDD 1159
             CQ  G+ V  WR  + C + CP +SHY  C   CQ  CAA+   + C+  C EGC CD 
Sbjct: 1351 TCQTQGITVTGWRNYTSCTVTCPPNSHYESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDA 1410

Query: 1160 RFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVC 1219
             ++L+   CI    CGC  +G+Y         SDC+ RC C   + + C    C     C
Sbjct: 1411 GYVLNGKSCILPHSCGCYSDGKYYEPKQLFWNSDCTRRCRCFRRNVIQCDPRQCKSDEEC 1470

Query: 1220 EVKAEARNCWATR-GLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVV 1278
             ++   R C++T+   C+ + G    TFDGA     +   + LS+ C  L + I +  ++
Sbjct: 1471 ALRNGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPD-ISFQLII 1529

Query: 1279 AEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSL 1338
               +        +  V+ +  +  + +     V VNG +V++P     +  +  + +G L
Sbjct: 1530 NFDKWSAPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKI-YSSEGFL 1588

Query: 1339 LVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAM 1392
            ++     +Q++      + + +S     K+CG CGNF+GD T+D+   + KP +
Sbjct: 1589 VIDTSPDIQIYYNGFNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVV 1642



 Score =  496 bits (1276), Expect = e-140
 Identities = 294/865 (33%), Positives = 420/865 (48%), Gaps = 36/865 (4%)

Query: 410  GCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQ-HGCQP 468
            GC + G +   G  FW D  C+  CRC      + C  ASC   EVC   P G+   C  
Sbjct: 259  GCTSRGQFLRRGEVFWDDLNCTVKCRCLDFNNEIYCQEASCSPYEVCE--PKGKFFYCSA 316

Query: 469  VSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV 528
            V T+ C  +G+PHY T DG  F FQG+C YLL+  C         F+V   NEHR   AV
Sbjct: 317  VETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCL-QTSSLPFFSVEAKNEHRRGSAV 375

Query: 529  SYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLD-SLLHAHLSGADVVVTTTSGL 587
            S+ + +++++  + + +      +++V+ +  +LP  LD   +  + SG    V T  GL
Sbjct: 376  SWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGL 435

Query: 588  SLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGA 639
             + FDG  +  + VP +Y  S CGLCGNYN++P DD     G+PA         W+V  A
Sbjct: 436  LVTFDGQHYASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHA 495

Query: 640  Q-GCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDA 698
               C       C + C    +  + G D CG ++ TDGPL  C  +V P  +   C+ D 
Sbjct: 496  DWKCDSGCVDNC-TQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDL 554

Query: 699  CQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFC--PLQCPAHSHYELCGDSCPVSC 756
            C V+ +   LC A+  Y   CQA G  +G+WR    C   +QCP+ SHY +C  SCP +C
Sbjct: 555  CSVRDNGTLLCQAIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDTC 614

Query: 757  PSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERR 816
              L+A   C + C EGC C+ GFVLS   CVP+ +CGC  DG YY +GE F+    C  +
Sbjct: 615  SDLTASRNCATPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQ 674

Query: 817  CECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHG 876
            C C  GG V C     CG  E C +EDG Q C       CL +      T DG  Y    
Sbjct: 675  CLCEEGGDVYC-FNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPS 733

Query: 877  SCSYVLAQVCHPKPGDEDFSIVLEKNAAGD--LQRLLVTVAGQVVSLA--QGQQVTVDGE 932
              SY L + C  +P   +  I  +K  AG   L+ L + VA Q V +      +V ++G+
Sbjct: 734  EFSYTLLKTCPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQ 793

Query: 933  AVALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLL-MSIPSPFRGRLCGLCGNF 989
             V LP     G++ +    +N     +KG+  +   D  LL + + + +     GLCG +
Sbjct: 794  EVELPFFHPSGKLEI-YRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFY 852

Query: 990  NGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGP--QGCPVCLAEETAPYESN 1047
            N N SD+F LPNG    ++  F  +W      + C   CG   + C    +E    Y S 
Sbjct: 853  NANASDEFCLPNGKCTDNLAVFLESWTT--FEEICNGECGDLLKACNND-SELLKFYRSR 909

Query: 1048 EACGQLRNP-QGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGV 1106
              CG + +P    F  C  V++ + Y+R C++ LC   G+++ LC S+A Y +AC+ A V
Sbjct: 910  SRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADV 969

Query: 1107 AVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQG 1166
             V PWRT  FCPL CP +SH+  C  TC  +C  L+    C   C EGC+CD+ + L   
Sbjct: 970  EVGPWRTYDFCPLECPENSHFEECI-TCTETCETLTLGPICVDSCSEGCQCDEGYALLGS 1028

Query: 1167 VCIPVQDCGCTHNGRYLPVNSSL-LTSDCSERCSCSSSSG-LTCQAAGCPPGRVCEVKAE 1224
             C+   +CGC   G  L  N +  +  DC   C CS +   + C+   C     C  +  
Sbjct: 1029 QCVTRSECGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNRVHCETIPCKDDEYCMEEGG 1088

Query: 1225 ARNCWA-TRGLCVLSVGANLTTFDG 1248
               C A T   C++S   +  TFDG
Sbjct: 1089 LYYCQARTDASCIVSGYGHYLTFDG 1113



 Score =  487 bits (1253), Expect = e-137
 Identities = 307/1097 (27%), Positives = 484/1097 (44%), Gaps = 50/1097 (4%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C   TC   E C  + G   C P  E  C L  +   H+FDG  + F    +Y L  T  
Sbjct: 685  CFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPSEFSYTLLKT-- 742

Query: 107  LGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALP 166
                      +     N+ + +   +++R + +      + I      +V++NG    LP
Sbjct: 743  ----CPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQEVELP 798

Query: 167  VSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNN 226
                 G++ + +  +   + +   + V Y     + + L ++Y     GLCG  + N ++
Sbjct: 799  FFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFYNANASD 858

Query: 227  DQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDR--LEQYEGPGFCGPLA 284
            +   PNG    ++ ++  SW    ++ +C  EC      C  D   L+ Y     CG + 
Sbjct: 859  EFCLPNGKCTDNLAVFLESWTT--FEEICNGECGDLLKACNNDSELLKFYRSRSRCGIIN 916

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
              +   F  CH  V   ++++ C+  +C  GG+   LC ++A Y +AC+ A V +  WR 
Sbjct: 917  DPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRT 976

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVP 404
               C + CPENSH+E C   C  +C +   LT   +C   C EGCQCD G+ L   +CV 
Sbjct: 977  YDFCPLECPENSHFEEC-ITCTETCET---LTLGPICVDSCSEGCQCDEGYALLGSQCVT 1032

Query: 405  LNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQH 464
             +  CGC   G        FW D  C  +C C      + C    C   E C +   G +
Sbjct: 1033 RSE-CGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNRVHCETIPCKDDEYC-MEEGGLY 1090

Query: 465  GCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGA-ENFTVTVANEHR 523
             CQ  + A C   G  HY+T DG  FDFQ +C  +L      P   +   F VT  NE R
Sbjct: 1091 YCQARTDASCIVSGYGHYLTFDGFPFDFQTSCPLILCTTGSRPSSDSFPKFVVTAKNEDR 1150

Query: 524  GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLSGADVVVT 582
                  + + V + ++ +S+ +   +   + V+   + LP +L    ++    G  VVV 
Sbjct: 1151 DPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVE 1210

Query: 583  TTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQ-- 640
            T  GL + +D  +F+ + VP +   S  GLCG YN +P DDL+   G  A       Q  
Sbjct: 1211 TDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFGQSW 1270

Query: 641  ---------GCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYF 691
                     GCG+     CPS    E          C +I   +   + CH  V P  ++
Sbjct: 1271 VKRDTFCQVGCGD----RCPSCAKVEGFSKV--QQLCSLIPNQNAAFSKCHSKVNPTFFY 1324

Query: 692  QGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDS 751
            + CL D+C   G     C  +  Y + CQ  G  +  WR    C + CP +SHYE C   
Sbjct: 1325 KNCLFDSCIDGGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTCPPNSHYESCVSV 1384

Query: 752  CPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGP 811
            C   C ++     C   C EGC CDAG+VL+G +C+    CGC  DG+YY   ++F+   
Sbjct: 1385 CQPRCAAIRLKSDCSHYCVEGCHCDAGYVLNGKSCILPHSCGCYSDGKYYEPKQLFW-NS 1443

Query: 812  ECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRV 871
            +C RRC C     + C +   C   EEC L +GV+ C +T    CLA GG  + T DG  
Sbjct: 1444 DCTRRCRCFRRNVIQC-DPRQCKSDEECALRNGVRGCFSTKTSYCLAAGGGVFRTFDGAF 1502

Query: 872  YDLHGSCSYVLAQVCHPKPGDEDFSIVL--EKNAAGDL---QRLLVTVAGQVVSLAQGQQ 926
                 +C++VL+ +C   P D  F +++  +K +A +L     +   +  + + +     
Sbjct: 1503 LRFPANCAFVLSTICQKLP-DISFQLIINFDKWSAPNLTIISPVYFYINEEQILINDRNT 1561

Query: 927  VTVDGEAVALPVAVG-RVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGL 985
            V V+G  V +P   G   ++ +    +V+ T+  +++ ++G   + +SI    + ++CGL
Sbjct: 1562 VKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISISERLQNKVCGL 1621

Query: 986  CGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSK-----GCGEGCGPQGCPVCLAEE 1040
            CGNFNG+ +DD+V   G    S      +W+  G  K      C E    Q   +C    
Sbjct: 1622 CGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNELQFSQYAAMCDNVH 1681

Query: 1041 TAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAA 1100
                + +  C +L + +G F  C  +L P  ++  C  D C     K  LC SLAAY  A
Sbjct: 1682 IQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YSHKKFQLCGSLAAYGEA 1740

Query: 1101 CQAAGVAVKPWRTDSFC 1117
            C++ G+    W     C
Sbjct: 1741 CRSFGILSTEWIEKENC 1757



 Score =  307 bits (787), Expect = 4e-83
 Identities = 193/611 (31%), Positives = 290/611 (47%), Gaps = 29/611 (4%)

Query: 793  GCLHDGRYYPLGEVFYPGPECERRCECGP-GGHVTCQEGAACGPHEECRLEDGVQACHAT 851
            GC   G++   GEVF+    C  +C C      + CQE A+C P+E C  +     C A 
Sbjct: 259  GCTSRGQFLRRGEVFWDDLNCTVKCRCLDFNNEIYCQE-ASCSPYEVCEPKGKFFYCSAV 317

Query: 852  GCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK-----NAAGD 906
                C+  G  HY T DG ++   GSC+Y+LA+ C        FS+  +      +A   
Sbjct: 318  ETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSW 377

Query: 907  LQRLLVTVAGQVVSLAQGQ--QVTVDGEAVALPVA--VGRVRVTAEGRNMVLQTTKGLRL 962
            ++ L V V G  + + +G   +V V+    +LPV   +G V++   G +  ++T  GL +
Sbjct: 378  VKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLV 437

Query: 963  LFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSK 1022
             FDG  +  +S+P  +    CGLCGN+N N  DDF+ P+G  A SV   G +WRV  +  
Sbjct: 438  TFDGQHYASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADW 497

Query: 1023 GCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA 1082
             C  GC    C  C A   A Y  ++ CG L    GP   C  V+ P+ +   CVYDLC+
Sbjct: 498  KCDSGC-VDNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCS 556

Query: 1083 QKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFC--PLHCPAHSHYSICTRTCQGSCAA 1140
             + +   LC+++ AY   CQA G+ +  WRT + C   + CP+ SHYS+CT +C  +C+ 
Sbjct: 557  VRDNGTLLCQAIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDTCSD 616

Query: 1141 LSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSL-LTSDCSERCS 1199
            L+    C T C EGCEC+  F+LS   C+P+  CGC  +G Y  +      T++C+ +C 
Sbjct: 617  LTASRNCATPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCL 676

Query: 1200 CSSSSGLTCQAAGCPPGRVCEVKAEARNCWATR-GLCVLSVGANLTTFDGARGATTSPGV 1258
            C     + C    C  G VC V+   + C+  R  +C+LS    L TFDGA  A  S   
Sbjct: 677  CEEGGDVYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPSEFS 736

Query: 1259 YELSSRCPGLQNTIPWYRVVAEVQICHGKTEA----VGQVHIFFQDGMVTL--TPNKGVW 1312
            Y L   CP      P Y    E+ I   K +A    +  + I   D  V +       V 
Sbjct: 737  YTLLKTCP----ERPEY---LEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVK 789

Query: 1313 VNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGAC 1372
            +NG  V+LP    +          S  V  K  V V     G + + +S  +     G C
Sbjct: 790  LNGQEVELPFFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLC 849

Query: 1373 GNFDGDQTNDW 1383
            G ++ + ++++
Sbjct: 850  GFYNANASDEF 860


>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
          Length = 2812

 Score =  686 bits (1769), Expect = 0.0
 Identities = 449/1392 (32%), Positives = 655/1392 (47%), Gaps = 96/1392 (6%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            C    C     C+ + GQ  C P    ATC ++GDPHY +FDGR F F G C Y+LA   
Sbjct: 1127 CQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGFMGKCTYILAQP- 1185

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
              G ST     F VT KNE +G   VS +  V V    + +++ K    +  V G    L
Sbjct: 1186 -CGNSTDPF--FRVTAKNEEQGQEGVSCLSKVYVTLPESTVTLLKGR--RTLVGGQQVTL 1240

Query: 166  PVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            P   + G    A G    L   +FGL+V +D + ++ VT+ S+Y G +CGLCGN D N +
Sbjct: 1241 PAIPSKGVFLGASGRFVELQT-EFGLRVRWDGDQQLYVTVSSTYSGKLCGLCGNYDGNSD 1299

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLA 284
            ND +  +G+ A      G SW+     D  C      + P+C         GPGFCG L 
Sbjct: 1300 NDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQVVNSPSCDSSLQSSMSGPGFCGRLV 1359

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
              T GPF TC  HV   SFF  C+LD+C   G   +LC  +++    CQ AG  ++ WR 
Sbjct: 1360 D-THGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWRE 1418

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVP 404
               C + CP NS Y +C  PCP +C S     +   C   CVE C+C+ GFVLS   C+P
Sbjct: 1419 PHFCPMACPPNSKYSLCAKPCPDTCHSG---FSGMFCSDRCVEACECNPGFVLSGLECIP 1475

Query: 405  LNNGCGC-WANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQ 463
              + CGC    G+Y + G  ++  G C + C C      + C P  C   E CG    G 
Sbjct: 1476 -RSQCGCLHPAGSYFKVGERWYKPG-CKELCVC-ESNNRIRCQPWRCRAQEFCG-QQDGI 1531

Query: 464  HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHR 523
            +GC     A C A GDPHY+T DG    F GTC Y+L+ PC      +  F V+  NE+R
Sbjct: 1532 YGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPCWSRSQDS-YFVVSATNENR 1590

Query: 524  GS-QAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLSGADVVV 581
            G    VSY ++V + +++ S++L      K+ ++G  VALP  L    +   LS   V++
Sbjct: 1591 GGILEVSYIKAVHVTVFDLSISLLRGC--KVMLNGHRVALPVWLAQGRVTIRLSSNLVLL 1648

Query: 582  TTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG--WQVGGA 639
             T  GL + +DG   V + VP++Y   LCGLCGNYN +  DD      K AG   Q+G A
Sbjct: 1649 YTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKLAGDSMQLGAA 1708

Query: 640  QGCGECVSKPC------PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQG 693
                E     C      PS C  E   +      C ++    GP + CH +VPP   F  
Sbjct: 1709 WKLPESSEPGCFLVGGKPSSC-QENSMADAWNKNCAILINPQGPFSQCHQVVPPQSSFAS 1767

Query: 694  CLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCP 753
            C+   C  +G    LC ++  Y + C  AG Q   WR   FCP++CP  S Y  C   CP
Sbjct: 1768 CVHGQCGTKGDTTALCRSLQAYASLCAQAG-QAPAWRNRTFCPMRCPPGSSYSPCSSPCP 1826

Query: 754  VSCPSLSAPEGCESA--CREGCVCDAGFVLSGDTCVPVGQCGCLHD-GRYYPLGEVFYPG 810
             +C S++ P  C  A  C E C C  G +LSG +CVP+GQCGC    G Y+P+GE +Y  
Sbjct: 1827 DTCSSINNPRDCPKALPCAESCECQKGHILSGTSCVPLGQCGCTDPAGSYHPVGERWYTE 1886

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
              C R C C    ++TC + + C P++ C   DG+  C A+G G C   G  HY++ DG 
Sbjct: 1887 NTCTRLCTCSVHNNITCFQ-STCKPNQICWALDGLLRCRASGVGVCQLPGESHYVSFDGS 1945

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVL--EKNAAGD----LQRLLVTVAGQVVSLAQG 924
             + +  +C+ VL +VCHP      F I    EK   G     L  + + +    V+L +G
Sbjct: 1946 NHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYIDIYDAQVTLQKG 2005

Query: 925  QQVTVDGEAVALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRL 982
             +V ++ + V LP    +  V V +     ++    G+++ FDG+  L + IP+ + G++
Sbjct: 2006 HRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFDGNHLLEIEIPTTYYGKV 2065

Query: 983  CGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETA 1042
            CG+CGNFN    D+ ++P+   A+S   F  +W+       C          + + E+  
Sbjct: 2066 CGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQS--------LLVDEQQI 2117

Query: 1043 PYE----------------SNEAC-GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKG 1085
            P E                + E C   LR P   +A C + +  + +   C   LC   G
Sbjct: 2118 PAEQQENPSGNCRAADLRRAREKCEAALRAP--VWAQCASRIDLTPFLVDCANTLCEFGG 2175

Query: 1086 DKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGL- 1144
                LC++L A+ A CQ+ G+    WR  SFCPL CPA+S Y+ C  +C  SC  L G  
Sbjct: 2176 LYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSCSPSCWDLDGRC 2235

Query: 1145 --TGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTH-NGRYLPVNSSLLTSDCSERCSCS 1201
                  + C EGC C   ++LS+  C+P   CGC   +G  +P+  S ++S C+E+C C+
Sbjct: 2236 EGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSGCTEKCVCT 2295

Query: 1202 SSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYEL 1261
              + + C    CP G  C++ ++  N       CV       + +   R  T     Y L
Sbjct: 2296 GGA-IQCGDFRCPSGSHCQLTSDNSN-----SNCVSDKSEQCSVYGDPRYLTFDGFSYRL 2349

Query: 1262 SSRCP-GLQNTIPWYRVVAEVQICHGKTEA-VGQVHIFFQDGMVTLTPNKGVWVNGLRVD 1319
              R    L  T+       E  +  G+ +    +  IF Q+ + T+   K     GL + 
Sbjct: 2350 QGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQEVITTVYGYKVQLQAGLELV 2409

Query: 1320 LPAEKLASVSVSRTPDGSLLVR---------QKAGVQVWLGANGKVAVIVSNDHAGKLCG 1370
            +  +K+A   V   P+  L V              + V  G      + + + + G + G
Sbjct: 2410 VNNQKMA---VPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGRKNAVISLPSMYEGLVSG 2466

Query: 1371 ACGNFDGDQTND 1382
             CGN+D ++ ND
Sbjct: 2467 LCGNYDKNRKND 2478



 Score =  647 bits (1669), Expect = 0.0
 Identities = 392/1088 (36%), Positives = 550/1088 (50%), Gaps = 63/1088 (5%)

Query: 352  CPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGC 411
            CP N+ YE C   CPASC SP P   P      C EGC C+ GF+ S + C+  ++ C C
Sbjct: 1044 CPPNARYESCA--CPASCKSPRPSCGPL-----CREGCVCNPGFLFSDNHCIQASS-CNC 1095

Query: 412  WANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVS- 470
            + N  Y+E G+E W    C++ CRC PG   + C  + CG   VC L  +GQ+GC P + 
Sbjct: 1096 FYNNDYYEPGAE-WFSPNCTEHCRCWPGS-RVECQISQCGTHTVCQL-KNGQYGCHPYAG 1152

Query: 471  TAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSY 530
            TA C  +GDPHYVT DG  F F G C Y+L+ PC         F VT  NE +G + VS 
Sbjct: 1153 TATCLVYGDPHYVTFDGRHFGFMGKCTYILAQPCGNST--DPFFRVTAKNEEQGQEGVSC 1210

Query: 531  TRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLA 590
               V + +   ++TL     R+  V G  V LP      +    SG  V + T  GL + 
Sbjct: 1211 LSKVYVTLPESTVTLLKG--RRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVR 1268

Query: 591  FDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGA--Q 640
            +DGD  + + V + Y+  LCGLCGNY+ +  +D   + G PAG        WQ      Q
Sbjct: 1269 WDGDQQLYVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQ 1328

Query: 641  GCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQ 700
             C +      PS C    Q S  GP  CG +  T GP   C   V  A +F  C+LD C 
Sbjct: 1329 ECQKYQVVNSPS-CDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCG 1387

Query: 701  VQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLS 760
             QG    LC  ++T    CQ AG  +  WR P FCP+ CP +S Y LC   CP +C S  
Sbjct: 1388 FQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCHSGF 1447

Query: 761  APEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPECERRCEC 819
            +   C   C E C C+ GFVLSG  C+P  QCGCLH  G Y+ +GE +Y  P C+  C C
Sbjct: 1448 SGMFCSDRCVEACECNPGFVLSGLECIPRSQCGCLHPAGSYFKVGERWYK-PGCKELCVC 1506

Query: 820  GPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCS 879
                 + CQ    C   E C  +DG+  CHA G   C A+G  HY+T DG ++   G+C+
Sbjct: 1507 ESNNRIRCQPW-RCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCT 1565

Query: 880  YVLAQVCHPKPGDEDFSI-VLEKNAAGDLQ-----RLLVTVAGQVVSLAQGQQVTVDGEA 933
            YVL + C  +  D  F +    +N  G L+      + VTV    +SL +G +V ++G  
Sbjct: 1566 YVLTRPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHR 1625

Query: 934  VALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNG 991
            VALPV  A GRV +      ++L T  GL++ +DG   + +++PS + G+LCGLCGN+N 
Sbjct: 1626 VALPVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNN 1685

Query: 992  NWSDDFVLPNGSAASSVETFGAAWRVPGSSK-GCG-EGCGPQGCPVCLAEETAPYESNEA 1049
            N  DD + P+   A      GAAW++P SS+ GC   G  P  C     E +     N+ 
Sbjct: 1686 NSLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKPSSC----QENSMADAWNKN 1741

Query: 1050 CGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVK 1109
            C  L NPQGPF+ C  V+ P   F  CV+  C  KGD   LCRSL AY + C  AG A  
Sbjct: 1742 CAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQA-P 1800

Query: 1110 PWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGC--TTRCFEGCECDDRFLLSQGV 1167
             WR  +FCP+ CP  S YS C+  C  +C++++    C     C E CEC    +LS   
Sbjct: 1801 AWRNRTFCPMRCPPGSSYSPCSSPCPDTCSSINNPRDCPKALPCAESCECQKGHILSGTS 1860

Query: 1168 CIPVQDCGCTH-NGRYLPVNSSLLTSD-CSERCSCSSSSGLTCQAAGCPPGRVCEVKAEA 1225
            C+P+  CGCT   G Y PV     T + C+  C+CS  + +TC  + C P ++C      
Sbjct: 1861 CVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCSVHNNITCFQSTCKPNQICWALDGL 1920

Query: 1226 RNCWATR-GLCVLSVGANLTTFDGARGATTSPGVYELSSRC-PGLQNTIPWYRVVAEVQI 1283
              C A+  G+C L   ++  +FDG+  +        L   C P +   +P++++ A+ + 
Sbjct: 1921 LRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCHPAM--ALPFFKISAKHEK 1978

Query: 1284 CHGKTEA--VGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPA-EKLASVSVSRTPDGSLLV 1340
              G TEA  + +V+I   D  VTL     V +N  +V LPA  ++  VSV  +   S +V
Sbjct: 1979 EEGGTEAFRLHEVYIDIYDAQVTLQKGHRVLINSKQVTLPAISQIPGVSVKSSSIYS-IV 2037

Query: 1341 RQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPA------MEK 1394
              K GVQV    N  + + +   + GK+CG CGNF+ ++ ++     ++ A      +  
Sbjct: 2038 NIKIGVQVKFDGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNS 2097

Query: 1395 WRAQDFSP 1402
            W+ +D  P
Sbjct: 2098 WKDKDIDP 2105



 Score =  561 bits (1446), Expect = e-159
 Identities = 391/1243 (31%), Positives = 573/1243 (46%), Gaps = 109/1243 (8%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C    CR QE C +Q G   C     ATC   GDPHY +FDG    F GTC YVL T  C
Sbjct: 1514 CQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVL-TRPC 1572

Query: 107  LGVSTQGLTPFTVTTKNENRGNPA-VSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               S      F V+  NENRG    VSY++ V V     +IS+ +    KV +NG   AL
Sbjct: 1573 WSRSQDSY--FVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRG--CKVMLNGHRVAL 1628

Query: 166  PVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            PV +A GR+++   ++  LL  +FGLQV YD +  V+VT+PSSY G +CGLCGN + N  
Sbjct: 1629 PVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSL 1688

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLA 284
            +D + P+  LA      G +W+ P   +P C+    G   +C E+ +           + 
Sbjct: 1689 DDNLRPDRKLAGDSMQLGAAWKLPESSEPGCF-LVGGKPSSCQENSMADAWNKNCAILIN 1747

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
            P   GPF+ CH  VPP+S F  CV   C   GD   LC++L +Y + C  AG     WR 
Sbjct: 1748 PQ--GPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQA-PAWRN 1804

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG--PCVEGCQCDAGFVLSADRC 402
            +  C + CP  S Y  C  PCP +C S   +  P  C    PC E C+C  G +LS   C
Sbjct: 1805 RTFCPMRCPPGSSYSPCSSPCPDTCSS---INNPRDCPKALPCAESCECQKGHILSGTSC 1861

Query: 403  VPLNNGCGCW-ANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPS 461
            VPL   CGC    G+YH  G  ++ + TC++ C C     ++ C  ++C   ++C  L  
Sbjct: 1862 VPLGQ-CGCTDPAGSYHPVGERWYTENTCTRLCTCSVHN-NITCFQSTCKPNQICWAL-D 1918

Query: 462  GQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANE 521
            G   C+      CQ  G+ HYV+ DG        C  +L   CH P +    F ++  +E
Sbjct: 1919 GLLRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCH-PAMALPFFKISAKHE 1977

Query: 522  -HRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADV- 579
               G         V + IY+  +TL      ++ ++   V LP  +  +    +  + + 
Sbjct: 1978 KEEGGTEAFRLHEVYIDIYDAQVTLQKG--HRVLINSKQVTLP-AISQIPGVSVKSSSIY 2034

Query: 580  -VVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGG 638
             +V    G+ + FDG+  + + +P  Y   +CG+CGN+N +  D+L     + A      
Sbjct: 2035 SIVNIKIGVQVKFDGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVAN---SD 2091

Query: 639  AQGCGECVSKPCPSPCTP----------EQQESFGGPDACGVI--------SATDGPL-A 679
            ++       K     C            EQQE+  G      +        +A   P+ A
Sbjct: 2092 SEFVNSWKDKDIDPSCQSLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWA 2151

Query: 680  PCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQC 739
             C   +    +   C    C+  G    LC A+  + A CQ+ G +   WR   FCPL+C
Sbjct: 2152 QCASRIDLTPFLVDCANTLCEFGGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLEC 2211

Query: 740  PAHSHYELCGDSCPVSCPSLSAP-EGCE--SACREGCVCDAGFVLSGDTCVPVGQCGCLH 796
            PA+S Y  C  SC  SC  L    EG +  SAC EGC+C  G+VLS D CVP  QCGC  
Sbjct: 2212 PAYSSYTNCLPSCSPSCWDLDGRCEGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKD 2271

Query: 797  -DGRYYPLGEVFYPGPECERRCECGPGGHVTCQE-GAACGPHEECRLEDGVQACHATGCG 854
              G   PLG+ +     C  +C C  GG + C +     G H +   ++    C +    
Sbjct: 2272 AHGGSIPLGKSWVSSG-CTEKCVC-TGGAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSE 2329

Query: 855  RCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD------LQ 908
            +C   G   Y+T DG  Y L G  +YVL +     P   +  +V  +N          LQ
Sbjct: 2330 QCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQ 2389

Query: 909  RLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGR-VRVTAEGRNMVLQTTKGLRLLFDGD 967
             ++ TV G  V L  G ++ V+ + +A+P      +RVT  G+ + L T   L + F G 
Sbjct: 2390 EVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGR 2449

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRV---------- 1017
             + ++S+PS + G + GLCGN++ N  +D +LP+G+   ++ TFG +W V          
Sbjct: 2450 KNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTEDALLRFP 2509

Query: 1018 ---PGSSKGCGEGCGPQ-GCPV--CLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
               P   +G G   G + G  V  C  E+ A   S +AC  L +PQGPFA C   ++P  
Sbjct: 2510 RAIPAEEEGQGAELGLRTGLQVSECSPEQLAS-NSTQACRVLADPQGPFAACHQTVAPEP 2568

Query: 1072 YFRQCVYDLCA---QKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYS 1128
            +   CV DLC+    +  +   C+ L+ +       GV+ +          +  +  + +
Sbjct: 2569 FQEHCVLDLCSAQDPREQEELRCQVLSGH-------GVSSR----------YHISELYDT 2611

Query: 1129 ICTRTCQ-GSCAALSG-LTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVN 1186
            + +  CQ G    L G L G   +         R  L      P+ DCGCT NG Y  + 
Sbjct: 2612 LPSILCQPGRPRGLRGPLRGRLRQ-------HPRLCLQWHPEPPLADCGCTSNGIYYQLG 2664

Query: 1187 SSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCW 1229
            SS LT DCS+RC+C+SS  L C+   C  G VC +    + C+
Sbjct: 2665 SSFLTEDCSQRCTCASSRILLCEPFSCRAGEVCTLGNHTQGCF 2707



 Score =  376 bits (965), Expect = e-104
 Identities = 221/659 (33%), Positives = 316/659 (47%), Gaps = 25/659 (3%)

Query: 738  QCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD 797
            +CP ++ YE C  +CP SC   S    C   CREGCVC+ GF+ S + C+    C C ++
Sbjct: 1043 RCPPNARYESC--ACPASCK--SPRPSCGPLCREGCVCNPGFLFSDNHCIQASSCNCFYN 1098

Query: 798  GRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHA-TGCGRC 856
              YY  G  ++  P C   C C PG  V CQ  + CG H  C+L++G   CH   G   C
Sbjct: 1099 NDYYEPGAEWF-SPNCTEHCRCWPGSRVECQI-SQCGTHTVCQLKNGQYGCHPYAGTATC 1156

Query: 857  LANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLL 911
            L  G  HY+T DGR +   G C+Y+LAQ C     D  F +  +    G      L ++ 
Sbjct: 1157 LVYGDPHYVTFDGRHFGFMGKCTYILAQPC-GNSTDPFFRVTAKNEEQGQEGVSCLSKVY 1215

Query: 912  VTVAGQVVSLAQGQQVTVDGEAVALPVAVGR-VRVTAEGRNMVLQTTKGLRLLFDGDAHL 970
            VT+    V+L +G++  V G+ V LP    + V + A GR + LQT  GLR+ +DGD  L
Sbjct: 1216 VTLPESTVTLLKGRRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVRWDGDQQL 1275

Query: 971  LMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGP 1030
             +++ S + G+LCGLCGN++GN  +D +  +GS A   E  G +W+         +    
Sbjct: 1276 YVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQV 1335

Query: 1031 QGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFL 1090
               P C +   +       CG+L +  GPF TC   +  + +F  C+ D+C  +G +  L
Sbjct: 1336 VNSPSCDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLL 1395

Query: 1091 CRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG--CT 1148
            C  ++  T  CQ AG AVKPWR   FCP+ CP +S YS+C + C  +C   SG +G  C+
Sbjct: 1396 CTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCH--SGFSGMFCS 1453

Query: 1149 TRCFEGCECDDRFLLSQGVCIPVQDCGCTH-NGRYLPVNSSLLTSDCSERCSCSSSSGLT 1207
             RC E CEC+  F+LS   CIP   CGC H  G Y  V        C E C C S++ + 
Sbjct: 1454 DRCVEACECNPGFVLSGLECIPRSQCGCLHPAGSYFKVGERWYKPGCKELCVCESNNRIR 1513

Query: 1208 CQAAGCPPGRVCEVKAEARNCWAT-RGLCVLSVGANLTTFDGARGATTSPGVYELSSRCP 1266
            CQ   C     C  +     C A     C  S   +  TFDGA         Y L+  C 
Sbjct: 1514 CQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPC- 1572

Query: 1267 GLQNTIPWYRVVAEVQICHG---KTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAE 1323
                +   Y VV+      G   +   +  VH+   D  ++L     V +NG RV LP  
Sbjct: 1573 -WSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALPVW 1631

Query: 1324 KLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTND 1382
                    R     +L+    G+QV    +  V V V + + G+LCG CGN++ +  +D
Sbjct: 1632 LAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDD 1690



 Score =  137 bits (345), Expect = 7e-32
 Identities = 121/423 (28%), Positives = 170/423 (40%), Gaps = 54/423 (12%)

Query: 67   CLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR 126
            C+ +    C ++GDP Y +FDG  +  QG   YVL  T  + V  +G+ P  V  +N+  
Sbjct: 2323 CVSDKSEQCSVYGDPRYLTFDGFSYRLQGRMTYVLIKT--VDVLPEGVEPLLVEGRNKMD 2380

Query: 127  GNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLV 186
               +  +++ V     G  + +      ++ VN    A+P    +  + V     +  LV
Sbjct: 2381 PPRSSIFLQEVITTVYGYKVQLQAGL--ELVVNNQKMAVPYRPNE-HLRVTLWGQRLYLV 2437

Query: 187  ADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSW 246
             DF L VS+       ++LPS Y G V GLCGN D+N  ND + P+G L  ++  +G SW
Sbjct: 2438 TDFELVVSFGGRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSW 2497

Query: 247  RAPGWDPL--------CWDECRGS---------CPTCPEDRLEQYEGPGFCGPLAPGTGG 289
                 D L          +E +G+            C  ++L        C  LA   G 
Sbjct: 2498 EVKTEDALLRFPRAIPAEEEGQGAELGLRTGLQVSECSPEQLASNSTQA-CRVLADPQG- 2555

Query: 290  PFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCE 349
            PF  CH  V PE F + CVLD+C      +                    E+ R QV   
Sbjct: 2556 PFAACHQTVAPEPFQEHCVLDLCSAQDPREQ-------------------EELRCQVLSG 2596

Query: 350  ITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGC 409
                   H        P+    P     P    GP     +      L      PL + C
Sbjct: 2597 HGVSSRYHISELYDTLPSILCQPG---RPRGLRGPLRGRLRQHPRLCLQWHPEPPLAD-C 2652

Query: 410  GCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQH--GCQ 467
            GC +NG Y++ GS F  +  CSQ C C      L+C P SC  GEVC L   G H  GC 
Sbjct: 2653 GCTSNGIYYQLGSSFLTE-DCSQRCTCA-SSRILLCEPFSCRAGEVCTL---GNHTQGCF 2707

Query: 468  PVS 470
            P S
Sbjct: 2708 PES 2710


>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
          Length = 2721

 Score =  686 bits (1769), Expect = 0.0
 Identities = 449/1392 (32%), Positives = 655/1392 (47%), Gaps = 96/1392 (6%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            C    C     C+ + GQ  C P    ATC ++GDPHY +FDGR F F G C Y+LA   
Sbjct: 1127 CQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGFMGKCTYILAQP- 1185

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
              G ST     F VT KNE +G   VS +  V V    + +++ K    +  V G    L
Sbjct: 1186 -CGNSTDPF--FRVTAKNEEQGQEGVSCLSKVYVTLPESTVTLLKGR--RTLVGGQQVTL 1240

Query: 166  PVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            P   + G    A G    L   +FGL+V +D + ++ VT+ S+Y G +CGLCGN D N +
Sbjct: 1241 PAIPSKGVFLGASGRFVELQT-EFGLRVRWDGDQQLYVTVSSTYSGKLCGLCGNYDGNSD 1299

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLA 284
            ND +  +G+ A      G SW+     D  C      + P+C         GPGFCG L 
Sbjct: 1300 NDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQVVNSPSCDSSLQSSMSGPGFCGRLV 1359

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
              T GPF TC  HV   SFF  C+LD+C   G   +LC  +++    CQ AG  ++ WR 
Sbjct: 1360 D-THGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWRE 1418

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVP 404
               C + CP NS Y +C  PCP +C S     +   C   CVE C+C+ GFVLS   C+P
Sbjct: 1419 PHFCPMACPPNSKYSLCAKPCPDTCHSG---FSGMFCSDRCVEACECNPGFVLSGLECIP 1475

Query: 405  LNNGCGC-WANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQ 463
              + CGC    G+Y + G  ++  G C + C C      + C P  C   E CG    G 
Sbjct: 1476 -RSQCGCLHPAGSYFKVGERWYKPG-CKELCVC-ESNNRIRCQPWRCRAQEFCG-QQDGI 1531

Query: 464  HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHR 523
            +GC     A C A GDPHY+T DG    F GTC Y+L+ PC      +  F V+  NE+R
Sbjct: 1532 YGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPCWSRSQDS-YFVVSATNENR 1590

Query: 524  GS-QAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHAHLSGADVVV 581
            G    VSY ++V + +++ S++L      K+ ++G  VALP  L    +   LS   V++
Sbjct: 1591 GGILEVSYIKAVHVTVFDLSISLLRGC--KVMLNGHRVALPVWLAQGRVTIRLSSNLVLL 1648

Query: 582  TTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG--WQVGGA 639
             T  GL + +DG   V + VP++Y   LCGLCGNYN +  DD      K AG   Q+G A
Sbjct: 1649 YTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKLAGDSMQLGAA 1708

Query: 640  QGCGECVSKPC------PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQG 693
                E     C      PS C  E   +      C ++    GP + CH +VPP   F  
Sbjct: 1709 WKLPESSEPGCFLVGGKPSSC-QENSMADAWNKNCAILINPQGPFSQCHQVVPPQSSFAS 1767

Query: 694  CLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCP 753
            C+   C  +G    LC ++  Y + C  AG Q   WR   FCP++CP  S Y  C   CP
Sbjct: 1768 CVHGQCGTKGDTTALCRSLQAYASLCAQAG-QAPAWRNRTFCPMRCPPGSSYSPCSSPCP 1826

Query: 754  VSCPSLSAPEGCESA--CREGCVCDAGFVLSGDTCVPVGQCGCLHD-GRYYPLGEVFYPG 810
             +C S++ P  C  A  C E C C  G +LSG +CVP+GQCGC    G Y+P+GE +Y  
Sbjct: 1827 DTCSSINNPRDCPKALPCAESCECQKGHILSGTSCVPLGQCGCTDPAGSYHPVGERWYTE 1886

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
              C R C C    ++TC + + C P++ C   DG+  C A+G G C   G  HY++ DG 
Sbjct: 1887 NTCTRLCTCSVHNNITCFQ-STCKPNQICWALDGLLRCRASGVGVCQLPGESHYVSFDGS 1945

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVL--EKNAAGD----LQRLLVTVAGQVVSLAQG 924
             + +  +C+ VL +VCHP      F I    EK   G     L  + + +    V+L +G
Sbjct: 1946 NHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYIDIYDAQVTLQKG 2005

Query: 925  QQVTVDGEAVALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRL 982
             +V ++ + V LP    +  V V +     ++    G+++ FDG+  L + IP+ + G++
Sbjct: 2006 HRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFDGNHLLEIEIPTTYYGKV 2065

Query: 983  CGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETA 1042
            CG+CGNFN    D+ ++P+   A+S   F  +W+       C          + + E+  
Sbjct: 2066 CGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQS--------LLVDEQQI 2117

Query: 1043 PYE----------------SNEAC-GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKG 1085
            P E                + E C   LR P   +A C + +  + +   C   LC   G
Sbjct: 2118 PAEQQENPSGNCRAADLRRAREKCEAALRAP--VWAQCASRIDLTPFLVDCANTLCEFGG 2175

Query: 1086 DKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGL- 1144
                LC++L A+ A CQ+ G+    WR  SFCPL CPA+S Y+ C  +C  SC  L G  
Sbjct: 2176 LYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSCSPSCWDLDGRC 2235

Query: 1145 --TGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTH-NGRYLPVNSSLLTSDCSERCSCS 1201
                  + C EGC C   ++LS+  C+P   CGC   +G  +P+  S ++S C+E+C C+
Sbjct: 2236 EGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSGCTEKCVCT 2295

Query: 1202 SSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYEL 1261
              + + C    CP G  C++ ++  N       CV       + +   R  T     Y L
Sbjct: 2296 GGA-IQCGDFRCPSGSHCQLTSDNSN-----SNCVSDKSEQCSVYGDPRYLTFDGFSYRL 2349

Query: 1262 SSRCP-GLQNTIPWYRVVAEVQICHGKTEA-VGQVHIFFQDGMVTLTPNKGVWVNGLRVD 1319
              R    L  T+       E  +  G+ +    +  IF Q+ + T+   K     GL + 
Sbjct: 2350 QGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQEVITTVYGYKVQLQAGLELV 2409

Query: 1320 LPAEKLASVSVSRTPDGSLLVR---------QKAGVQVWLGANGKVAVIVSNDHAGKLCG 1370
            +  +K+A   V   P+  L V              + V  G      + + + + G + G
Sbjct: 2410 VNNQKMA---VPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGRKNAVISLPSMYEGLVSG 2466

Query: 1371 ACGNFDGDQTND 1382
             CGN+D ++ ND
Sbjct: 2467 LCGNYDKNRKND 2478



 Score =  647 bits (1669), Expect = 0.0
 Identities = 392/1088 (36%), Positives = 550/1088 (50%), Gaps = 63/1088 (5%)

Query: 352  CPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGC 411
            CP N+ YE C   CPASC SP P   P      C EGC C+ GF+ S + C+  ++ C C
Sbjct: 1044 CPPNARYESCA--CPASCKSPRPSCGPL-----CREGCVCNPGFLFSDNHCIQASS-CNC 1095

Query: 412  WANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVS- 470
            + N  Y+E G+E W    C++ CRC PG   + C  + CG   VC L  +GQ+GC P + 
Sbjct: 1096 FYNNDYYEPGAE-WFSPNCTEHCRCWPGS-RVECQISQCGTHTVCQL-KNGQYGCHPYAG 1152

Query: 471  TAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSY 530
            TA C  +GDPHYVT DG  F F G C Y+L+ PC         F VT  NE +G + VS 
Sbjct: 1153 TATCLVYGDPHYVTFDGRHFGFMGKCTYILAQPCGNST--DPFFRVTAKNEEQGQEGVSC 1210

Query: 531  TRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLA 590
               V + +   ++TL     R+  V G  V LP      +    SG  V + T  GL + 
Sbjct: 1211 LSKVYVTLPESTVTLLKG--RRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVR 1268

Query: 591  FDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGA--Q 640
            +DGD  + + V + Y+  LCGLCGNY+ +  +D   + G PAG        WQ      Q
Sbjct: 1269 WDGDQQLYVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQ 1328

Query: 641  GCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQ 700
             C +      PS C    Q S  GP  CG +  T GP   C   V  A +F  C+LD C 
Sbjct: 1329 ECQKYQVVNSPS-CDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCG 1387

Query: 701  VQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLS 760
             QG    LC  ++T    CQ AG  +  WR P FCP+ CP +S Y LC   CP +C S  
Sbjct: 1388 FQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCHSGF 1447

Query: 761  APEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPECERRCEC 819
            +   C   C E C C+ GFVLSG  C+P  QCGCLH  G Y+ +GE +Y  P C+  C C
Sbjct: 1448 SGMFCSDRCVEACECNPGFVLSGLECIPRSQCGCLHPAGSYFKVGERWYK-PGCKELCVC 1506

Query: 820  GPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCS 879
                 + CQ    C   E C  +DG+  CHA G   C A+G  HY+T DG ++   G+C+
Sbjct: 1507 ESNNRIRCQPW-RCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCT 1565

Query: 880  YVLAQVCHPKPGDEDFSI-VLEKNAAGDLQ-----RLLVTVAGQVVSLAQGQQVTVDGEA 933
            YVL + C  +  D  F +    +N  G L+      + VTV    +SL +G +V ++G  
Sbjct: 1566 YVLTRPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHR 1625

Query: 934  VALPV--AVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNG 991
            VALPV  A GRV +      ++L T  GL++ +DG   + +++PS + G+LCGLCGN+N 
Sbjct: 1626 VALPVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNN 1685

Query: 992  NWSDDFVLPNGSAASSVETFGAAWRVPGSSK-GCG-EGCGPQGCPVCLAEETAPYESNEA 1049
            N  DD + P+   A      GAAW++P SS+ GC   G  P  C     E +     N+ 
Sbjct: 1686 NSLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKPSSC----QENSMADAWNKN 1741

Query: 1050 CGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVK 1109
            C  L NPQGPF+ C  V+ P   F  CV+  C  KGD   LCRSL AY + C  AG A  
Sbjct: 1742 CAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQA-P 1800

Query: 1110 PWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGC--TTRCFEGCECDDRFLLSQGV 1167
             WR  +FCP+ CP  S YS C+  C  +C++++    C     C E CEC    +LS   
Sbjct: 1801 AWRNRTFCPMRCPPGSSYSPCSSPCPDTCSSINNPRDCPKALPCAESCECQKGHILSGTS 1860

Query: 1168 CIPVQDCGCTH-NGRYLPVNSSLLTSD-CSERCSCSSSSGLTCQAAGCPPGRVCEVKAEA 1225
            C+P+  CGCT   G Y PV     T + C+  C+CS  + +TC  + C P ++C      
Sbjct: 1861 CVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCSVHNNITCFQSTCKPNQICWALDGL 1920

Query: 1226 RNCWATR-GLCVLSVGANLTTFDGARGATTSPGVYELSSRC-PGLQNTIPWYRVVAEVQI 1283
              C A+  G+C L   ++  +FDG+  +        L   C P +   +P++++ A+ + 
Sbjct: 1921 LRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCHPAM--ALPFFKISAKHEK 1978

Query: 1284 CHGKTEA--VGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPA-EKLASVSVSRTPDGSLLV 1340
              G TEA  + +V+I   D  VTL     V +N  +V LPA  ++  VSV  +   S +V
Sbjct: 1979 EEGGTEAFRLHEVYIDIYDAQVTLQKGHRVLINSKQVTLPAISQIPGVSVKSSSIYS-IV 2037

Query: 1341 RQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPA------MEK 1394
              K GVQV    N  + + +   + GK+CG CGNF+ ++ ++     ++ A      +  
Sbjct: 2038 NIKIGVQVKFDGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNS 2097

Query: 1395 WRAQDFSP 1402
            W+ +D  P
Sbjct: 2098 WKDKDIDP 2105



 Score =  541 bits (1393), Expect = e-153
 Identities = 362/1133 (31%), Positives = 527/1133 (46%), Gaps = 83/1133 (7%)

Query: 47   CHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGC 106
            C    CR QE C +Q G   C     ATC   GDPHY +FDG    F GTC YVL T  C
Sbjct: 1514 CQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVL-TRPC 1572

Query: 107  LGVSTQGLTPFTVTTKNENRGNPA-VSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               S      F V+  NENRG    VSY++ V V     +IS+ +    KV +NG   AL
Sbjct: 1573 WSRSQDSY--FVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRG--CKVMLNGHRVAL 1628

Query: 166  PVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            PV +A GR+++   ++  LL  +FGLQV YD +  V+VT+PSSY G +CGLCGN + N  
Sbjct: 1629 PVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSL 1688

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLA 284
            +D + P+  LA      G +W+ P   +P C+    G   +C E+ +           + 
Sbjct: 1689 DDNLRPDRKLAGDSMQLGAAWKLPESSEPGCF-LVGGKPSSCQENSMADAWNKNCAILIN 1747

Query: 285  PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
            P   GPF+ CH  VPP+S F  CV   C   GD   LC++L +Y + C  AG     WR 
Sbjct: 1748 PQ--GPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQA-PAWRN 1804

Query: 345  QVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG--PCVEGCQCDAGFVLSADRC 402
            +  C + CP  S Y  C  PCP +C S   +  P  C    PC E C+C  G +LS   C
Sbjct: 1805 RTFCPMRCPPGSSYSPCSSPCPDTCSS---INNPRDCPKALPCAESCECQKGHILSGTSC 1861

Query: 403  VPLNNGCGCW-ANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPS 461
            VPL   CGC    G+YH  G  ++ + TC++ C C     ++ C  ++C   ++C  L  
Sbjct: 1862 VPLGQ-CGCTDPAGSYHPVGERWYTENTCTRLCTCSVHN-NITCFQSTCKPNQICWAL-D 1918

Query: 462  GQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANE 521
            G   C+      CQ  G+ HYV+ DG        C  +L   CH P +    F ++  +E
Sbjct: 1919 GLLRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCH-PAMALPFFKISAKHE 1977

Query: 522  -HRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADV- 579
               G         V + IY+  +TL      ++ ++   V LP  +  +    +  + + 
Sbjct: 1978 KEEGGTEAFRLHEVYIDIYDAQVTLQKG--HRVLINSKQVTLP-AISQIPGVSVKSSSIY 2034

Query: 580  -VVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGG 638
             +V    G+ + FDG+  + + +P  Y   +CG+CGN+N +  D+L     + A      
Sbjct: 2035 SIVNIKIGVQVKFDGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVAN---SD 2091

Query: 639  AQGCGECVSKPCPSPCTP----------EQQESFGGPDACGVI--------SATDGPL-A 679
            ++       K     C            EQQE+  G      +        +A   P+ A
Sbjct: 2092 SEFVNSWKDKDIDPSCQSLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWA 2151

Query: 680  PCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQC 739
             C   +    +   C    C+  G    LC A+  + A CQ+ G +   WR   FCPL+C
Sbjct: 2152 QCASRIDLTPFLVDCANTLCEFGGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLEC 2211

Query: 740  PAHSHYELCGDSCPVSCPSLSAP-EGCE--SACREGCVCDAGFVLSGDTCVPVGQCGCLH 796
            PA+S Y  C  SC  SC  L    EG +  SAC EGC+C  G+VLS D CVP  QCGC  
Sbjct: 2212 PAYSSYTNCLPSCSPSCWDLDGRCEGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKD 2271

Query: 797  -DGRYYPLGEVFYPGPECERRCECGPGGHVTCQE-GAACGPHEECRLEDGVQACHATGCG 854
              G   PLG+ +     C  +C C  GG + C +     G H +   ++    C +    
Sbjct: 2272 AHGGSIPLGKSWVSSG-CTEKCVC-TGGAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSE 2329

Query: 855  RCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD------LQ 908
            +C   G   Y+T DG  Y L G  +YVL +     P   +  +V  +N          LQ
Sbjct: 2330 QCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQ 2389

Query: 909  RLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGR-VRVTAEGRNMVLQTTKGLRLLFDGD 967
             ++ TV G  V L  G ++ V+ + +A+P      +RVT  G+ + L T   L + F G 
Sbjct: 2390 EVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGR 2449

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRV---------- 1017
             + ++S+PS + G + GLCGN++ N  +D +LP+G+   ++ TFG +W V          
Sbjct: 2450 KNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTEDALLRFP 2509

Query: 1018 ---PGSSKGCGEGCGPQ-GCPV--CLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
               P   +G G   G + G  V  C  E+ A   S +AC  L +PQGPFA C   ++P  
Sbjct: 2510 RAIPAEEEGQGAELGLRTGLQVSECSPEQLAS-NSTQACRVLADPQGPFAACHQTVAPEP 2568

Query: 1072 YFRQCVYDLCA---QKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
            +   CV DLC+    +  +   C+ L+ Y   CQ AG A+  WR  + C   C
Sbjct: 2569 FQEHCVLDLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRDRTLCESPC 2621



 Score =  376 bits (965), Expect = e-104
 Identities = 221/659 (33%), Positives = 316/659 (47%), Gaps = 25/659 (3%)

Query: 738  QCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHD 797
            +CP ++ YE C  +CP SC   S    C   CREGCVC+ GF+ S + C+    C C ++
Sbjct: 1043 RCPPNARYESC--ACPASCK--SPRPSCGPLCREGCVCNPGFLFSDNHCIQASSCNCFYN 1098

Query: 798  GRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHA-TGCGRC 856
              YY  G  ++  P C   C C PG  V CQ  + CG H  C+L++G   CH   G   C
Sbjct: 1099 NDYYEPGAEWF-SPNCTEHCRCWPGSRVECQI-SQCGTHTVCQLKNGQYGCHPYAGTATC 1156

Query: 857  LANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLL 911
            L  G  HY+T DGR +   G C+Y+LAQ C     D  F +  +    G      L ++ 
Sbjct: 1157 LVYGDPHYVTFDGRHFGFMGKCTYILAQPC-GNSTDPFFRVTAKNEEQGQEGVSCLSKVY 1215

Query: 912  VTVAGQVVSLAQGQQVTVDGEAVALPVAVGR-VRVTAEGRNMVLQTTKGLRLLFDGDAHL 970
            VT+    V+L +G++  V G+ V LP    + V + A GR + LQT  GLR+ +DGD  L
Sbjct: 1216 VTLPESTVTLLKGRRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVRWDGDQQL 1275

Query: 971  LMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGP 1030
             +++ S + G+LCGLCGN++GN  +D +  +GS A   E  G +W+         +    
Sbjct: 1276 YVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQV 1335

Query: 1031 QGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFL 1090
               P C +   +       CG+L +  GPF TC   +  + +F  C+ D+C  +G +  L
Sbjct: 1336 VNSPSCDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLL 1395

Query: 1091 CRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG--CT 1148
            C  ++  T  CQ AG AVKPWR   FCP+ CP +S YS+C + C  +C   SG +G  C+
Sbjct: 1396 CTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCH--SGFSGMFCS 1453

Query: 1149 TRCFEGCECDDRFLLSQGVCIPVQDCGCTH-NGRYLPVNSSLLTSDCSERCSCSSSSGLT 1207
             RC E CEC+  F+LS   CIP   CGC H  G Y  V        C E C C S++ + 
Sbjct: 1454 DRCVEACECNPGFVLSGLECIPRSQCGCLHPAGSYFKVGERWYKPGCKELCVCESNNRIR 1513

Query: 1208 CQAAGCPPGRVCEVKAEARNCWAT-RGLCVLSVGANLTTFDGARGATTSPGVYELSSRCP 1266
            CQ   C     C  +     C A     C  S   +  TFDGA         Y L+  C 
Sbjct: 1514 CQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPC- 1572

Query: 1267 GLQNTIPWYRVVAEVQICHG---KTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAE 1323
                +   Y VV+      G   +   +  VH+   D  ++L     V +NG RV LP  
Sbjct: 1573 -WSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALPVW 1631

Query: 1324 KLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTND 1382
                    R     +L+    G+QV    +  V V V + + G+LCG CGN++ +  +D
Sbjct: 1632 LAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDD 1690



 Score =  133 bits (335), Expect = 1e-30
 Identities = 91/309 (29%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 67   CLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR 126
            C+ +    C ++GDP Y +FDG  +  QG   YVL  T  + V  +G+ P  V  +N+  
Sbjct: 2323 CVSDKSEQCSVYGDPRYLTFDGFSYRLQGRMTYVLIKT--VDVLPEGVEPLLVEGRNKMD 2380

Query: 127  GNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLV 186
               +  +++ V     G  + +      ++ VN    A+P    +  + V     +  LV
Sbjct: 2381 PPRSSIFLQEVITTVYGYKVQLQAGL--ELVVNNQKMAVPYRPNE-HLRVTLWGQRLYLV 2437

Query: 187  ADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSW 246
             DF L VS+       ++LPS Y G V GLCGN D+N  ND + P+G L  ++  +G SW
Sbjct: 2438 TDFELVVSFGGRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSW 2497

Query: 247  RAPGWDPL--------CWDECRGS---------CPTCPEDRLEQYEGPGFCGPLAPGTGG 289
                 D L          +E +G+            C  ++L        C  LA    G
Sbjct: 2498 EVKTEDALLRFPRAIPAEEEGQGAELGLRTGLQVSECSPEQLAS-NSTQACRVLA-DPQG 2555

Query: 290  PFTTCHAHVPPESFFKGCVLDVCMGGG---DHDILCKALASYVAACQAAGVVIEDWRAQV 346
            PF  CH  V PE F + CVLD+C         ++ C+ L+ Y   CQ AG  +  WR + 
Sbjct: 2556 PFAACHQTVAPEPFQEHCVLDLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRDRT 2615

Query: 347  GCEITCPEN 355
             CE  C +N
Sbjct: 2616 LCESPCLQN 2624


>gi|239757284 PREDICTED: similar to Fc fragment of IgG binding
           protein [Homo sapiens]
          Length = 593

 Score =  546 bits (1408), Expect = e-155
 Identities = 251/256 (98%), Positives = 254/256 (99%)

Query: 21  VDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGD 80
           VD+EGAA+LYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGD
Sbjct: 318 VDVEGAAILYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGD 377

Query: 81  PHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVA 140
           PHYHSFDGRKFDFQGTCNYVLATTGC GVSTQGLTPFTVTTKN+NRGNPAVSYVRVVTVA
Sbjct: 378 PHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVA 437

Query: 141 ALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWR 200
           ALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISV QGASKALLVADFGLQVSYDWNWR
Sbjct: 438 ALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWR 497

Query: 201 VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECR 260
           VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECR
Sbjct: 498 VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECR 557

Query: 261 GSCPTCPEDRLEQYEG 276
           GSCPTCPEDRLEQYEG
Sbjct: 558 GSCPTCPEDRLEQYEG 573



 Score =  323 bits (827), Expect = 9e-88
 Identities = 192/569 (33%), Positives = 273/569 (47%), Gaps = 101/569 (17%)

Query: 570  LHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGG 629
            + A   G+DVV+ T  GL +A+D   +VR+ VP  Y   +CGLCGNYN DP DD +    
Sbjct: 12   IRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQ---- 67

Query: 630  KPAGWQVGGAQGCGECVSK-----------PCPS---------PCTPEQQESFGGPDACG 669
            KP G Q G A   G    +           PCP           C PE ++ +   + CG
Sbjct: 68   KPNGSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCG 127

Query: 670  VISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEW 729
            ++S+  GPL+ CH LV P    + C+ D C   G+   LC  +  YV+ACQAAG  +  W
Sbjct: 128  LLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPW 187

Query: 730  RRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPV 789
            R   FCP++CP +SHYELC D+C + C +LSAP  C+  C EGC CD+GF+ +G  CVP+
Sbjct: 188  RTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNGQACVPI 247

Query: 790  GQCGCLHDGRYY-PLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGV--- 845
             QCGC H+G YY P   V      C ++C C  G  V CQE  +C P + C+   G+   
Sbjct: 248  QQCGCYHNGVYYEPEQTVLI--DNCRQQCTCHAGKVVVCQE-HSCKPGQVCQPSGGILSC 304

Query: 846  -------------------------------------QACHATGC------------GRC 856
                                                   CH   C            G C
Sbjct: 305  VTKVTLRSLAQTGVDVEGAAILYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGGQGVC 364

Query: 857  LAN--------GGIHYITLDGRVYDLHGSCSYVLAQVCHP---KPGDEDFSIVLEKNAAG 905
            L N        G  HY + DGR +D  G+C+YVLA    P     G   F++  +    G
Sbjct: 365  LPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRG 424

Query: 906  D-----LQRLLVTVAGQVVSLAQGQ--QVTVDGEAVALPVAV--GRVRVTAEGRNMVLQT 956
            +     ++ + V   G  +S+ + +  +V V+G   ALPV+V  GR+ VT      +L  
Sbjct: 425  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVA 484

Query: 957  TKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWR 1016
              GL++ +D +  + +++PS + G +CGLCGN + N ++D V PNG+ A S+  +G +WR
Sbjct: 485  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 544

Query: 1017 VPGSSKGCGEGCGPQGCPVCLAEETAPYE 1045
             PG    C + C    CP C  +    YE
Sbjct: 545  APGWDPLCWDEC-RGSCPTCPEDRLEQYE 572



 Score =  322 bits (826), Expect = 1e-87
 Identities = 197/583 (33%), Positives = 289/583 (49%), Gaps = 91/583 (15%)

Query: 165 LPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNP 224
           LPV +A+G+I  +Q  S  ++  DFGL+V+YD  + V VT+P +Y+  +CGLCGN + +P
Sbjct: 3   LPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDP 62

Query: 225 NNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT----------CPEDRLEQY 274
            +D   PNG+ A +   +G SW     D  C       CP           CP +  ++Y
Sbjct: 63  KDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPT--PCPPGSEDCIPSHKCPPELEKKY 120

Query: 275 EGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQA 334
           +   FCG L+  TG P ++CH  V P+   K C+ D+C+GGG+  ILC  + +YV+ACQA
Sbjct: 121 QKEEFCGLLSSPTG-PLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQA 179

Query: 335 AGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAG 394
           AG  +E WR +  C + CP NSHYE+C   C   C   + L+ P  C+  C EGCQCD+G
Sbjct: 180 AGGHVEPWRTETFCPMECPPNSHYELCADTCSLGC---SALSAPPQCQDGCAEGCQCDSG 236

Query: 395 FVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGE 454
           F+ +   CVP+   CGC+ NG Y+E       D  C Q C C   G  +VC   SC  G+
Sbjct: 237 FLYNGQACVPIQQ-CGCYHNGVYYEPEQTVLID-NCRQQCTC-HAGKVVVCQEHSCKPGQ 293

Query: 455 VC----------------------------GLLPSGQ--------------HG--CQPVS 470
           VC                             +L +GQ              HG  C+P  
Sbjct: 294 VCQPSGGILSCVTKVTLRSLAQTGVDVEGAAILYNGQPLKVLLPLLSPDPCHGVTCRPQE 353

Query: 471 T---------------AECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP-CHG-PPLGAEN 513
           T               A C  WGDPHY + DG +FDFQGTC Y+L+   C G    G   
Sbjct: 354 TCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTP 413

Query: 514 FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQL-DSLLHA 572
           FTVT  N++RG+ AVSY R VT+     ++++      K++V+GV  ALP  + D  +  
Sbjct: 414 FTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISV 473

Query: 573 HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA 632
               +  ++    GL +++D +  V + +P++Y  ++CGLCGN +++P +D     G  A
Sbjct: 474 TQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLA 533

Query: 633 --------GWQVGGAQG-CGECVSKPCPSPCTPEQQESFGGPD 666
                    W+  G    C +     CP+ C  ++ E + G D
Sbjct: 534 PSIPIWGGSWRAPGWDPLCWDECRGSCPT-CPEDRLEQYEGLD 575



 Score =  255 bits (652), Expect = 2e-67
 Identities = 116/303 (38%), Positives = 175/303 (57%), Gaps = 11/303 (3%)

Query: 936  LPVAV--GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNW 993
            LPV +  G++R +  G ++V++T  GLR+ +D   ++ +++P  +  ++CGLCGN+NG+ 
Sbjct: 3    LPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDP 62

Query: 994  SDDFVLPNGSAASSVETFGAAWR--VPGSSKGCGEGCGPQGCPVCLAEETAP------YE 1045
             DDF  PNGS A +   FG +W   VP S       C P G   C+     P      Y+
Sbjct: 63   KDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPC-PPGSEDCIPSHKCPPELEKKYQ 121

Query: 1046 SNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAG 1105
              E CG L +P GP ++C  ++ P    + C++DLC   G+ + LC ++ AY +ACQAAG
Sbjct: 122  KEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAG 181

Query: 1106 VAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ 1165
              V+PWRT++FCP+ CP +SHY +C  TC   C+ALS    C   C EGC+CD  FL + 
Sbjct: 182  GHVEPWRTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNG 241

Query: 1166 GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEA 1225
              C+P+Q CGC HNG Y     ++L  +C ++C+C +   + CQ   C PG+VC+     
Sbjct: 242  QACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKVVVCQEHSCKPGQVCQPSGGI 301

Query: 1226 RNC 1228
             +C
Sbjct: 302  LSC 304



 Score = 32.0 bits (71), Expect = 4.3
 Identities = 17/60 (28%), Positives = 33/60 (55%), Gaps = 1/60 (1%)

Query: 1325 LASVSVSRTPDGS-LLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
            LA+  +  +  GS +++    G++V       V V V  ++  ++CG CGN++GD  +D+
Sbjct: 7    LANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDF 66


>gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens]
          Length = 2013

 Score =  362 bits (928), Expect = 2e-99
 Identities = 328/1207 (27%), Positives = 481/1207 (39%), Gaps = 207/1207 (17%)

Query: 75   CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
            C  WG  HY +FDG  F F G CNYV +     G + +         +++    P +S V
Sbjct: 81   CSTWGSFHYKTFDGDVFRFPGLCNYVFSEH--CGAAYEDFN--IQLRRSQESAAPTLSRV 136

Query: 135  RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVS 194
                +   G  I + K   G V VNG    LP S +   + + Q +S   + A  GL + 
Sbjct: 137  ---LMKVDGVVIQLTK---GSVLVNGHPVLLPFSQSG--VLIQQSSSYTKVEARLGLVLM 188

Query: 195  YDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPL 254
            ++ +  + + L + Y    CGLCG+ +  P   ++  + T     P+  G+ +    DP 
Sbjct: 189  WNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLT--PMEFGNLQKMD-DPT 245

Query: 255  CWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMG 314
              ++C+   P  P +      G G C  L  G    F+ C A V   S+ + C  D+C  
Sbjct: 246  --EQCQDPVPEPPRNCST---GFGICEELLHGQ--LFSGCVALVDVGSYLEACRQDLCFC 298

Query: 315  GGDHDIL---CKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPS 371
              D D+L   C  LA Y   C  AG + +DWR    C   CP N  Y  C  PC  +C +
Sbjct: 299  E-DTDLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCADTCSN 357

Query: 372  PAPLTTPAVCEGPCVEGCQCDAGFVLS---ADRCVPLNNGCGCWANGTYHEAGSEFWADG 428
                     CE  CV GC C  G VL       CVP++  C C  NG  +  G+ +  D 
Sbjct: 358  QEH---SRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSK-CACVYNGAAYAPGATYSTD- 412

Query: 429  TCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVST-AECQAWGDPHYVTLDG 487
                            CT  +C           G+  CQ V     C   G  H+ T DG
Sbjct: 413  ----------------CTNCTCS---------GGRWSCQEVPCPGTCSVLGGAHFSTFDG 447

Query: 488  HRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTLQIYNHSLTLS 546
             ++   G C Y+L+ PC      +  FTV       G + + +  +SVTL +      + 
Sbjct: 448  KQYTVHGDCSYVLTKPCD-----SSAFTVLAELRRCGLTDSETCLKSVTLSLDGVQTVVV 502

Query: 547  ARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAA-- 604
             +   ++ ++ ++  LP    ++     S   ++  T+ GL L       ++L +  A  
Sbjct: 503  IKASGEVFLNQIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPK 562

Query: 605  YAASLCGLCGNYNQDPADDLKAVGG-----KPAGWQVGGAQGCGECVSKPCPSPCTPEQQ 659
                 CGLCGN+N   ADD + + G       A +     Q     +      PC+   +
Sbjct: 563  LRGQTCGLCGNFNSIQADDFRTLSGVVEATAAAFFNTFKTQAACPNIRNSFEDPCSLSVE 622

Query: 660  ESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAAC 719
                    C  ++  DGP   CH  V P  Y+  C+ D C  +     LC A+++YV AC
Sbjct: 623  NEKYAQHWCSQLTDADGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHAC 682

Query: 720  QAAGAQLGEWRRPDFCP---LQCPAHSHYELCGDSCPVSCPSLSAPEGCESACR------ 770
             A G QLG WR    C      CP    Y     +C  +C SLS  EG +  C       
Sbjct: 683  AAKGVQLGGWR-DGVCTKPMTTCPKSMTYHYHVSTCQPTCRSLS--EG-DITCSVGFIPV 738

Query: 771  EGCVCDAGFVLSGDT--CVPVGQCGCLHDGRYYPLGE----------------------- 805
            +GC+C  G  L  DT  CV    C C H G   P GE                       
Sbjct: 739  DGCICPKGTFLD-DTGKCVQASNCPCYHRGSMIPNGESVHDSGAICTCTHGKLSCIGGQA 797

Query: 806  ---------VFY------PG-------------------PECERRCEC-------GPGGH 824
                     VF+      PG                   P+C   C C       G GG 
Sbjct: 798  PAPVCAAPMVFFDCRNATPGDTGAGCQKSCHTLDMTCYSPQCVPGCVCPDGLVADGEGGC 857

Query: 825  VTCQEGAACGPHEE--------------CRLEDGVQACHATGC-GRCLANGGIHYITLDG 869
            +T ++   C  +E               C  +  +  C    C   C   G  HY+T DG
Sbjct: 858  ITAED-CPCVHNEASYRAGQTIRVGCNTCTCDSRMWRCTDDPCLATCAVYGDGHYLTFDG 916

Query: 870  RVYDLHGSCSYVLAQV-CHPKPGDED-FSIVLEKNAAGDL-----QRLLVTVAGQVVSLA 922
            + Y  +G C Y L Q  C  K   +D F +V E    G       + + + + G  + L+
Sbjct: 917  QSYSFNGDCEYTLVQNHCGGKDSTQDSFRVVTENVPCGTTGTTCSKAIKIFLGGFELKLS 976

Query: 923  QGQ-QVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGR 981
             G+ +V    E+  +P  + ++     G  +V+ T  GL LL+D    + +++   F+GR
Sbjct: 977  HGKVEVIGTDESQEVPYTIRQM-----GIYLVVDTDIGLVLLWDKKTSIFINLSPEFKGR 1031

Query: 982  LCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEET 1041
            +CGLCGNF+    +DF   + S    V  FG +W++   S  C +   P+    C A   
Sbjct: 1032 VCGLCGNFDDIAVNDFATRSRSVVGDVLEFGNSWKL---SPSCPDALAPK--DPCTANPF 1086

Query: 1042 APYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTA 1099
                + + C  L  P   FA C A + P+ Y+  CV D CA    GD    C ++AAY  
Sbjct: 1087 RKSWAQKQCSILHGP--TFAACHAHVEPARYYEACVNDACACDSGGDCECFCTAVAAYAQ 1144

Query: 1100 ACQAAGVAVKPWRTDSFCPLHCPAHS-------HYS----ICTRTC---QGSCAA-LSGL 1144
            AC   G+ V  WRT S CPL C  ++       HY      C RTC   +G C   + GL
Sbjct: 1145 ACHEVGLCVS-WRTPSICPLFCDYYNPEGQCEWHYQPCGVPCLRTCRNPRGDCLRDVWGL 1203

Query: 1145 TGCTTRC 1151
             GC  +C
Sbjct: 1204 EGCYPKC 1210



 Score =  288 bits (736), Expect = 3e-77
 Identities = 268/1037 (25%), Positives = 389/1037 (37%), Gaps = 197/1037 (18%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-----SQAV 528
            C  WG  HY T DG  F F G C Y+ S  C       E+F + +           S+ +
Sbjct: 81   CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGA---AYEDFNIQLRRSQESAAPTLSRVL 137

Query: 529  SYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLS 588
                 V +Q+   S+           V+G  V LPF    +L    S +   V    GL 
Sbjct: 138  MKVDGVVIQLTKGSVL----------VNGHPVLLPFSQSGVL-IQQSSSYTKVEARLGLV 186

Query: 589  LAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPA-DDLKAVGGKPAGWQVGGAQGCGECVS 647
            L ++ D  + L +   YA   CGLCG++N  P   +L +   K    + G  Q   +  +
Sbjct: 187  LMWNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPMEFGNLQKMDD-PT 245

Query: 648  KPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGCLLDACQVQGHP- 705
            + C  P     +    G   C  +    G L + C  LV    Y + C  D C  +    
Sbjct: 246  EQCQDPVPEPPRNCSTGFGICEEL--LHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDL 303

Query: 706  -GGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
               +C  +A Y   C  AG    +WR PDFCP +CP +  Y  C   C  +C +      
Sbjct: 304  LSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCADTCSNQEHSRA 363

Query: 765  CESACREGCVCDAGFVLS--GDT-CVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGP 821
            CE  C  GC C  G VL   G T CVPV +C C+++G  Y  G  +    +C   C C  
Sbjct: 364  CEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAPGATY--STDCTN-CTCS- 419

Query: 822  GGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYV 881
            GG  +CQE   C                    G C   GG H+ T DG+ Y +HG CSYV
Sbjct: 420  GGRWSCQE-VPCP-------------------GTCSVLGGAHFSTFDGKQYTVHGDCSYV 459

Query: 882  LAQVCHPKPGDEDFSIVLEKNAAG--DLQRLLVTVA------GQVVSLAQGQQVTVDGEA 933
            L + C        F+++ E    G  D +  L +V         VV +    +V ++   
Sbjct: 460  LTKPCDSSA----FTVLAELRRCGLTDSETCLKSVTLSLDGVQTVVVIKASGEVFLNQIY 515

Query: 934  VALPVAVGRVRVTAEGRNMVL-QTTKGLRLLFD--GDAHLLMSIPSPFRGRLCGLCGNFN 990
              LP++   V +       ++ QT+ GL+L         L M +    RG+ CGLCGNFN
Sbjct: 516  TQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFN 575

Query: 991  GNWSDDFVLPNG----SAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYES 1046
               +DDF   +G    +AA+   TF      P       + C        L+ E   Y +
Sbjct: 576  SIQADDFRTLSGVVEATAAAFFNTFKTQAACPNIRNSFEDPCS-------LSVENEKY-A 627

Query: 1047 NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGV 1106
               C QL +  GPF  C A + P  Y+  C++D C  +  +  LC +L++Y  AC A GV
Sbjct: 628  QHWCSQLTDADGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGV 687

Query: 1107 AVKPWRTDSFCP---LHCPAHSHYSICTRTCQGSCAALS-GLTGCTTRCF--EGCECDD- 1159
             +  WR D  C      CP    Y     TCQ +C +LS G   C+      +GC C   
Sbjct: 688  QLGGWR-DGVCTKPMTTCPKSMTYHYHVSTCQPTCRSLSEGDITCSVGFIPVDGCICPKG 746

Query: 1160 RFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTS--------------------------- 1192
             FL   G C+   +C C H G  +P   S+  S                           
Sbjct: 747  TFLDDTGKCVQASNCPCYHRGSMIPNGESVHDSGAICTCTHGKLSCIGGQAPAPVCAAPM 806

Query: 1193 ---DCSERCSCSSSSG---------LTCQAAGCPPGRVCE-----------VKAEARNC- 1228
               DC       + +G         +TC +  C PG VC            + AE   C 
Sbjct: 807  VFFDCRNATPGDTGAGCQKSCHTLDMTCYSPQCVPGCVCPDGLVADGEGGCITAEDCPCV 866

Query: 1229 -------------------------WATR-----GLCVLSVGANLTTFDGARGATTSPGV 1258
                                     W          C +    +  TFDG   +      
Sbjct: 867  HNEASYRAGQTIRVGCNTCTCDSRMWRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCE 926

Query: 1259 YEL-SSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGV--WVNG 1315
            Y L  + C G  +T   +RVV E   C                G    T +K +  ++ G
Sbjct: 927  YTLVQNHCGGKDSTQDSFRVVTENVPC----------------GTTGTTCSKAIKIFLGG 970

Query: 1316 LRVDLPAEKLASVSVSRTPDGSLLVRQKA---------GVQVWLGANGKVAVIVSNDHAG 1366
              + L   K+  +    + +    +RQ           G+ +       + + +S +  G
Sbjct: 971  FELKLSHGKVEVIGTDESQEVPYTIRQMGIYLVVDTDIGLVLLWDKKTSIFINLSPEFKG 1030

Query: 1367 KLCGACGNFDGDQTNDW 1383
            ++CG CGNFD    ND+
Sbjct: 1031 RVCGLCGNFDDIAVNDF 1047



 Score =  226 bits (576), Expect = 1e-58
 Identities = 248/996 (24%), Positives = 382/996 (38%), Gaps = 176/996 (17%)

Query: 6    CGLACSNPQ------IPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCK 59
            C   C  P+      I  T  V +   A +YNG          +P   +   C     C 
Sbjct: 368  CVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAY-------APGATYSTDCT---NCT 417

Query: 60   EQGGQGVCLP-NYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118
              GG+  C       TC + G  H+ +FDG+++   G C+YVL T  C        + FT
Sbjct: 418  CSGGRWSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVL-TKPC------DSSAFT 470

Query: 119  VTTKNENRG-NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVA 177
            V  +    G   + + ++ VT++  G    +     G+V +N + T LP+S A+  +++ 
Sbjct: 471  VLAELRRCGLTDSETCLKSVTLSLDGVQTVVVIKASGEVFLNQIYTQLPISAAN--VTIF 528

Query: 178  QGASKALLV-ADFGLQVSYDW--NWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGT 234
            + ++  ++     GLQ++       ++ + L     G  CGLCGN +    +D    +G 
Sbjct: 529  RPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGV 588

Query: 235  LAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTC 294
            +  +   +  +++     P   +     C    E+  E+Y    +C  L     GPF  C
Sbjct: 589  VEATAAAFFNTFKTQAACPNIRNSFEDPCSLSVEN--EKY-AQHWCSQLT-DADGPFGRC 644

Query: 295  HAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCE--ITC 352
            HA V P +++  C+ D C      D LC AL+SYV AC A GV +  WR  V  +   TC
Sbjct: 645  HAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWRDGVCTKPMTTC 704

Query: 353  PENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAG-FVLSADRCVPLNNGCGC 411
            P++  Y      C  +C S +            V+GC C  G F+    +CV  +N C C
Sbjct: 705  PKSMTYHYHVSTCQPTCRSLSEGDITCSVGFIPVDGCICPKGTFLDDTGKCVQASN-CPC 763

Query: 412  WANGTYHEAGSEFWADG---TCSQW----------------------CRCGPGGGS---- 442
            +  G+    G      G   TC+                        CR    G +    
Sbjct: 764  YHRGSMIPNGESVHDSGAICTCTHGKLSCIGGQAPAPVCAAPMVFFDCRNATPGDTGAGC 823

Query: 443  --------LVCTPASCGLGEVC--GLLPSGQHGC-------------------------- 466
                    + C    C  G VC  GL+  G+ GC                          
Sbjct: 824  QKSCHTLDMTCYSPQCVPGCVCPDGLVADGEGGCITAEDCPCVHNEASYRAGQTIRVGCN 883

Query: 467  ------------QPVSTAECQAWGDPHYVTLDGHRFDFQGTCEY-LLSAPCHGPPLGAEN 513
                             A C  +GD HY+T DG  + F G CEY L+   C G     ++
Sbjct: 884  TCTCDSRMWRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGKDSTQDS 943

Query: 514  FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVA--LPFQLDSLLH 571
            F V   N   G+   + ++++ + +    L LS     K++V G   +  +P+ +  +  
Sbjct: 944  FRVVTENVPCGTTGTTCSKAIKIFLGGFELKLS---HGKVEVIGTDESQEVPYTIRQM-- 998

Query: 572  AHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKP 631
                G  +VV T  GL L +D  + + + +   +   +CGLCGN++    +D        
Sbjct: 999  ----GIYLVVDTDIGLVLLWDKKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRSRSV 1054

Query: 632  AG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGP-LAPCH 682
             G        W++  +  C + ++     PCT            C ++    GP  A CH
Sbjct: 1055 VGDVLEFGNSWKL--SPSCPDALAP--KDPCTANPFRKSWAQKQCSIL---HGPTFAACH 1107

Query: 683  GLVPPAQYFQGCLLDACQVQ--GHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCP 740
              V PA+Y++ C+ DAC     G     C AVA Y  AC   G  +  WR P  CPL C 
Sbjct: 1108 AHVEPARYYEACVNDACACDSGGDCECFCTAVAAYAQACHEVGLCV-SWRTPSICPLFCD 1166

Query: 741  AHS-------HYELCGDSCPVSCPS--------LSAPEGCESAC-REGCVCDAGFVLSGD 784
             ++       HY+ CG  C  +C +        +   EGC   C  E  + D   +    
Sbjct: 1167 YYNPEGQCEWHYQPCGVPCLRTCRNPRGDCLRDVWGLEGCYPKCPPEAPIFDEDKMQCVA 1226

Query: 785  TC-VPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAAC-GPHEECRLE 842
            TC  P     C   G+ Y  G V      C+  C C   G     +  AC   +   R  
Sbjct: 1227 TCPTPPLPPRCHVHGKSYRPGAVVPSDKNCQ-SCLCTERGVECTYKAEACVCTYNGQRFH 1285

Query: 843  DGVQACHAT----GC--GRCLANGGIHYITLDGRVY 872
             G    H T    GC   RC ANG     T++ RVY
Sbjct: 1286 PGDVIYHTTDGTGGCISARCGANG-----TIERRVY 1316



 Score =  186 bits (471), Expect = 2e-46
 Identities = 153/557 (27%), Positives = 249/557 (44%), Gaps = 61/557 (10%)

Query: 845  VQACHATGCGR-CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVL---E 900
            V+A +    GR C   G  HY T DG V+   G C+YV ++ C      EDF+I L   +
Sbjct: 69   VRASNPAHNGRVCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGA--AYEDFNIQLRRSQ 126

Query: 901  KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGL 960
            ++AA  L R+L+ V G V+ L +G  V V+G  V LP +   V +        ++   GL
Sbjct: 127  ESAAPTLSRVLMKVDGVVIQLTKGS-VLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGL 185

Query: 961  RLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGS 1020
             L+++ D  LL+ + + +  + CGLCG+FNG      +L + +  + +E FG   ++   
Sbjct: 186  VLMWNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDP 244

Query: 1021 SKGCGEGC--GPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVY 1078
            ++ C +     P+ C                C +L + Q  F+ C A++    Y   C  
Sbjct: 245  TEQCQDPVPEPPRNCSTGFG----------ICEELLHGQ-LFSGCVALVDVGSYLEACRQ 293

Query: 1079 DLCAQKGDK--AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQG 1136
            DLC  +     + +C +LA Y+  C  AG   + WR   FCP  CP +  Y  C   C  
Sbjct: 294  DLCFCEDTDLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCAD 353

Query: 1137 SCAALSGLTGCTTRCFEGCECDDRFLL---SQGVCIPVQDCGCTHNG-RYLPVNSSLLTS 1192
            +C+       C   C  GC C +  +L    Q  C+PV  C C +NG  Y P   +  ++
Sbjct: 354  TCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAP--GATYST 411

Query: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252
            DC+  C+CS     +CQ   CP                  G C +  GA+ +TFDG +  
Sbjct: 412  DCT-NCTCSGGR-WSCQEVPCP------------------GTCSVLGGAHFSTFDGKQYT 451

Query: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICH-GKTEAVGQVHIFFQDGMVTLTPNKG- 1310
                  Y L+  C         + V+AE++ C    +E   +      DG+ T+   K  
Sbjct: 452  VHGDCSYVLTKPCDSSA-----FTVLAELRRCGLTDSETCLKSVTLSLDGVQTVVVIKAS 506

Query: 1311 --VWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQ--VWLGANGKVAVIVSNDHAG 1366
              V++N +   LP    A+V++ R     ++ +   G+Q  + L    ++ + ++    G
Sbjct: 507  GEVFLNQIYTQLPI-SAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRG 565

Query: 1367 KLCGACGNFDGDQTNDW 1383
            + CG CGNF+  Q +D+
Sbjct: 566  QTCGLCGNFNSIQADDF 582


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score =  357 bits (916), Expect = 4e-98
 Identities = 330/1237 (26%), Positives = 464/1237 (37%), Gaps = 183/1237 (14%)

Query: 73   ATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVS 132
            ATC  W   HY +FDGR + F G C Y+LA       +   LTP            P   
Sbjct: 193  ATCASWSGFHYRTFDGRHYHFLGRCTYLLAGAADSTWAVH-LTP--------GDRCPQPG 243

Query: 133  YVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQ 192
            + + VT+      I     + G V V G L     S     +S+       +L    G+ 
Sbjct: 244  HCQRVTMGPEEVLI-----QAGNVSVKGQLVPEGQSWLLHGLSLQWLGDWLVLSGGLGVV 298

Query: 193  VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 252
            V  D    + +++     G   GLCG  +  P +D + P G LA     +G SWR PG +
Sbjct: 299  VRLDRTGSISISVDHELWGQTQGLCGLYNGWPEDDFMEPGGGLAMLAATFGNSWRLPGSE 358

Query: 253  PLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGT-----GGPFTTCHAHVPPESFFKGC 307
              C D    +    P   ++    PG     A         GPF  CHA V P  + + C
Sbjct: 359  SGCLDAVEVAQGCDPLGLIDADVEPGHLRAEAQDVCHQLLEGPFGQCHAQVSPAEYHEAC 418

Query: 308  VLDVCMGG-------GDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV 360
            +   C G        G    +C   ASYV AC    + I  WR    CE  CP    Y  
Sbjct: 419  LFAYCAGAMAGSGQEGRQQAVCATFASYVQACARRHIHIR-WRKPGFCERLCPGGQLYSD 477

Query: 361  CGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEA 420
            C   CP SC +       + C   CV GC+C  G   +   CVP  + C C+        
Sbjct: 478  CVSLCPPSCEAVGQGEEES-CREECVSGCECPRGLFWNGTLCVPAAH-CPCY-------- 527

Query: 421  GSEFWADGTCSQWCRCGPGGG-SLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGD 479
                     C Q  R  PG     +C P  C  G          H  Q +  AEC   GD
Sbjct: 528  --------YCRQ--RYVPGDTVRQLCNPCVCRDGR--------WHCAQALCPAECAVGGD 569

Query: 480  PHYVTLDGHRFDFQG--TCEYLLSAPCHGPPLGAENFT---VTVANEHRGSQAVSYTRSV 534
             HY+T DG  + F G   C Y L           +++    + +  EH    A S   ++
Sbjct: 570  GHYLTFDGRSYSFWGGQGCRYSL----------VQDYVKGQLLILLEHGACDAGSCLHAI 619

Query: 535  TLQIYNHSLTLSARWPRKLQVDGVFVALPF-QLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
            ++ + +  + L  R    + V+G  V LP+   + L     S A +++       L    
Sbjct: 620  SVSLEDTHIQL--RDSGAVLVNGQDVGLPWIGAEGLSVRRASSAFLLLRWPGAQVLWGLS 677

Query: 594  DSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK--------PAGWQVGGAQGCGEC 645
            D    + +   +A  + GLCG + Q+  DD     G          + +QV G    G C
Sbjct: 678  DPVAYITLDPRHAHQVQGLCGTFTQNQQDDFLTPAGDVETSIAAFASKFQVAGK---GRC 734

Query: 646  VSKPCP--SPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQG 703
             S+     SPCT   Q       AC ++ ++      CH LV    ++  CL   C    
Sbjct: 735  PSEDSALLSPCTTHSQRHAFAEAACAILHSS--VFQECHRLVDKEPFYLRCLAAVCGCDP 792

Query: 704  HPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPE 763
                LCP ++ Y   C   GA    WR    CP+ CP    Y  C  +C   C     PE
Sbjct: 793  GSDCLCPVLSAYARRCAQEGAS-PPWRNQTLCPVMCPGGQEYRECAPACGQHC---GKPE 848

Query: 764  GCE--SACREGCVCDAGFVLSGD-TCVPVGQCGCLHDGRYYPLGE--------------- 805
             C    +C  GC C  G +   +  CVP   C C    R Y  G                
Sbjct: 849  DCGELGSCVAGCNCPLGLLWDPEGQCVPPSLCPCQLGARRYAPGSATMKECNRCICQERG 908

Query: 806  -------------------VFYPG--------PECERRCECGPGGHVTCQEGAA-----C 833
                               V+ PG        P     C  G      C  G       C
Sbjct: 909  LWNCTARHCPSQAFCPRELVYAPGACLLTCDSPSANHSCPAGSTDGCVCPPGTVLLDERC 968

Query: 834  GPHEEC-------------RLEDGVQAC-------HATG---CGRCLANGGIHYITLDGR 870
             P + C              +++    C       H TG    GRC A+G  HY+T DG 
Sbjct: 969  VPPDLCPCRHSGQWYLPNATIQEDCNVCVCRGRQWHCTGQRRSGRCQASGAPHYVTFDGL 1028

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD 930
             +   G+C Y+L +           ++    +     + L V + G VV + +G+ VTV+
Sbjct: 1029 AFTYPGACEYLLVREASGLFTVSAQNLPCGASGLTCTKALAVRLEGTVVHMLRGRAVTVN 1088

Query: 931  GEAVALP-VAVG-RVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGN 988
            G +V  P V  G  + +   G  ++L T  GL LL+DG   +L+ +   FRGR+ GLCG+
Sbjct: 1089 GVSVTPPKVYTGPGLSLRRAGLFLLLSTHLGLTLLWDGGTRVLVQLSPQFRGRVAGLCGD 1148

Query: 989  FNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNE 1048
            F+G+ S+D     G    + E    +WR+   S  C E  G    P  +    A + +  
Sbjct: 1149 FDGDASNDLRSRQGVLEPTAELAAHSWRL---SPLCPEP-GDLPHPCTMNTHRAGW-ARA 1203

Query: 1049 ACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTAACQAAGV 1106
             CG L  P   F  C A + P +++  C+YD C     GD   LC ++A Y   C   G 
Sbjct: 1204 RCGALLQPL--FTLCHAEVPPQQHYEWCLYDACGCDSGGDCECLCSAIATYADECARHGH 1261

Query: 1107 AVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGC---TTRCFEGCECDDRFLL 1163
             V+ WR+   C L C     Y  C  TC  +C       G       C EGC C +  LL
Sbjct: 1262 HVR-WRSQELCSLQCEGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLL 1320

Query: 1164 SQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC 1200
              G C+    C C       P   S+L  DC   C+C
Sbjct: 1321 HGGACLEPASCPCEWGRNSFP-PGSVLQKDCG-NCTC 1355



 Score =  263 bits (673), Expect = 7e-70
 Identities = 245/895 (27%), Positives = 342/895 (38%), Gaps = 152/895 (16%)

Query: 73   ATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVS 132
            A C + GD HY +FDGR + F G         GC     Q      +    E+    A S
Sbjct: 562  AECAVGGDGHYLTFDGRSYSFWGG-------QGCRYSLVQDYVKGQLLILLEHGACDAGS 614

Query: 133  YVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQ 192
             +  ++V+   T+I +   + G V VNG    LP   A+G +SV + +S  LL+   G Q
Sbjct: 615  CLHAISVSLEDTHIQLR--DSGAVLVNGQDVGLPWIGAEG-LSVRRASSAFLLLRWPGAQ 671

Query: 193  VSYDWNWRVD-VTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGW 251
            V +  +  V  +TL   +   V GLCG   +N  +D + P G +  SI  +   ++  G 
Sbjct: 672  VLWGLSDPVAYITLDPRHAHQVQGLCGTFTQNQQDDFLTPAGDVETSIAAFASKFQVAG- 730

Query: 252  DPLCWDECRGSCPT--------CPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESF 303
                    +G CP+        C             C  L       F  CH  V  E F
Sbjct: 731  --------KGRCPSEDSALLSPCTTHSQRHAFAEAACAILHSSV---FQECHRLVDKEPF 779

Query: 304  FKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGP 363
            +  C+  VC      D LC  L++Y   C   G     WR Q  C + CP    Y  C P
Sbjct: 780  YLRCLAAVCGCDPGSDCLCPVLSAYARRCAQEGAS-PPWRNQTLCPVMCPGGQEYRECAP 838

Query: 364  PCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSAD-RCVPLN---------------- 406
             C   C  P          G CV GC C  G +   + +CVP +                
Sbjct: 839  ACGQHCGKPEDCGEL----GSCVAGCNCPLGLLWDPEGQCVPPSLCPCQLGARRYAPGSA 894

Query: 407  -----NGCGCWANGTY-----HEAGSEF------WADGTCSQWC-------RCGPGG-GS 442
                 N C C   G +     H     F      +A G C   C        C  G    
Sbjct: 895  TMKECNRCICQERGLWNCTARHCPSQAFCPRELVYAPGACLLTCDSPSANHSCPAGSTDG 954

Query: 443  LVCTPASCGLGEVC---GLLP---SGQ----------------------HGCQPVSTAEC 474
             VC P +  L E C    L P   SGQ                      H      +  C
Sbjct: 955  CVCPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQEDCNVCVCRGRQWHCTGQRRSGRC 1014

Query: 475  QAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSV 534
            QA G PHYVT DG  F + G CEYLL     G       FTV+  N   G+  ++ T+++
Sbjct: 1015 QASGAPHYVTFDGLAFTYPGACEYLLVREASG------LFTVSAQNLPCGASGLTCTKAL 1068

Query: 535  TLQIYNHSLTLSARWPRKLQVDGVFVALP-FQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             +++      +     R + V+GV V  P       L    +G  ++++T  GL+L +DG
Sbjct: 1069 AVRL--EGTVVHMLRGRAVTVNGVSVTPPKVYTGPGLSLRRAGLFLLLSTHLGLTLLWDG 1126

Query: 594  DSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGG--KPAGWQVGGAQGCGECVSKP-- 649
             + V +++   +   + GLCG+++ D ++DL++  G  +P       +        +P  
Sbjct: 1127 GTRVLVQLSPQFRGRVAGLCGDFDGDASNDLRSRQGVLEPTAELAAHSWRLSPLCPEPGD 1186

Query: 650  CPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGCLLDACQVQ--GHPG 706
             P PCT     +      CG +     PL   CH  VPP Q+++ CL DAC     G   
Sbjct: 1187 LPHPCTMNTHRAGWARARCGALLQ---PLFTLCHAEVPPQQHYEWCLYDACGCDSGGDCE 1243

Query: 707  GLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG-- 764
             LC A+ATY   C   G  +  WR  + C LQC     YE CG +CP +C       G  
Sbjct: 1244 CLCSAIATYADECARHGHHV-RWRSQELCSLQCEGGQVYEACGPTCPPTCHEQHPEPGWH 1302

Query: 765  CE-SACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFY--------------- 808
            C+  AC EGC C  G +L G  C+    C C      +P G V                 
Sbjct: 1303 CQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHC 1362

Query: 809  --PGPECERRCECGPGGHVTCQEGAACGPH-------EECRLEDGVQACHATGCG 854
               G  CE        G   CQE   C PH       ++C      + C A GCG
Sbjct: 1363 GGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCG 1417



 Score =  246 bits (628), Expect = 1e-64
 Identities = 297/1212 (24%), Positives = 427/1212 (35%), Gaps = 225/1212 (18%)

Query: 341  DWRAQVGCEITCPENSHYEVCGPPCPASCPS-PAPLTTPAVCEG------PCVEGCQCDA 393
            D  +++G  +  P +    +   P P  CP    P T PA          P   G  C  
Sbjct: 46   DHYSRLGWRLDLPWSGRSGLTRSPAPGLCPIYKPPETRPAKWNRTVRTCCPGWGGAHCTE 105

Query: 394  GFVLSADR--CVPLNNGCGCWANGTYHEAGS----------EFWADGTCSQWCR-CG--- 437
                ++    C  +   C   A      AGS          + W DG+ SQ CR C    
Sbjct: 106  ALAKASPEGHCFAMWQ-CQLQAGSANASAGSLEECCARPWGQSWWDGS-SQACRSCSSRH 163

Query: 438  -PGGGS--LVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQG 494
             PG  S   +  P +  +G++       QH  +P +T  C +W   HY T DG  + F G
Sbjct: 164  LPGSASSPALLQPLAGAVGQLWS-----QHQ-RPSAT--CASWSGFHYRTFDGRHYHFLG 215

Query: 495  TCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQ 554
             C YLL+            + V +    R  Q   + + VT+             P ++ 
Sbjct: 216  RCTYLLAGAAD------STWAVHLTPGDRCPQP-GHCQRVTM------------GPEEVL 256

Query: 555  VDGVFVALPFQL-----DSLLHA---HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYA 606
            +    V++  QL       LLH       G  +V++   G+ +  D    + + V     
Sbjct: 257  IQAGNVSVKGQLVPEGQSWLLHGLSLQWLGDWLVLSGGLGVVVRLDRTGSISISVDHELW 316

Query: 607  ASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQ-GCGEC--VSKPCPSPCT 655
                GLCG YN  P DD    GG  A         W++ G++ GC +   V++ C     
Sbjct: 317  GQTQGLCGLYNGWPEDDFMEPGGGLAMLAATFGNSWRLPGSESGCLDAVEVAQGCDPLGL 376

Query: 656  PEQQESFG-----GPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQ-------VQG 703
             +     G       D C  +   +GP   CH  V PA+Y + CL   C         +G
Sbjct: 377  IDADVEPGHLRAEAQDVCHQL--LEGPFGQCHAQVSPAEYHEACLFAYCAGAMAGSGQEG 434

Query: 704  HPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSL--SA 761
                +C   A+YV AC      +  WR+P FC   CP    Y  C   CP SC ++    
Sbjct: 435  RQQAVCATFASYVQACARRHIHI-RWRKPGFCERLCPGGQLYSDCVSLCPPSCEAVGQGE 493

Query: 762  PEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGP 821
             E C   C  GC C  G   +G  CVP   C C      Y   + + PG    + C    
Sbjct: 494  EESCREECVSGCECPRGLFWNGTLCVPAAHCPC------YYCRQRYVPGDTVRQLC---- 543

Query: 822  GGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHYITLDGRVYDLHG--SC 878
                             C   DG   C    C   C   G  HY+T DGR Y   G   C
Sbjct: 544  ---------------NPCVCRDGRWHCAQALCPAECAVGGDGHYLTFDGRSYSFWGGQGC 588

Query: 879  SYVLAQVCHPKPGDEDFSIVLEKNA--AGD-LQRLLVTVAGQVVSLAQGQQVTVDGEAVA 935
             Y L Q            I+LE  A  AG  L  + V++    + L     V V+G+ V 
Sbjct: 589  RYSLVQ----DYVKGQLLILLEHGACDAGSCLHAISVSLEDTHIQLRDSGAVLVNGQDVG 644

Query: 936  LP-VAVGRVRVTAEGRNMVLQTTKGLRLLFD-GDAHLLMSIPSPFRGRLCGLCGNFNGNW 993
            LP +    + V       +L    G ++L+   D    +++      ++ GLCG F  N 
Sbjct: 645  LPWIGAEGLSVRRASSAFLLLRWPGAQVLWGLSDPVAYITLDPRHAHQVQGLCGTFTQNQ 704

Query: 994  SDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQL 1053
             DDF+ P G   +S+  F + ++V G  +   E         C         +  AC  L
Sbjct: 705  QDDFLTPAGDVETSIAAFASKFQVAGKGRCPSEDSAL--LSPCTTHSQRHAFAEAACAIL 762

Query: 1054 RNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRT 1113
             +    F  C  ++    ++ +C+  +C        LC  L+AY   C   G A  PWR 
Sbjct: 763  HS--SVFQECHRLVDKEPFYLRCLAAVCGCDPGSDCLCPVLSAYARRCAQEG-ASPPWRN 819

Query: 1114 DSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLS-QGVCIPVQ 1172
             + CP+ CP    Y  C   C   C       G    C  GC C    L   +G C+P  
Sbjct: 820  QTLCPVMCPGGQEYRECAPACGQHCGKPED-CGELGSCVAGCNCPLGLLWDPEGQCVPPS 878

Query: 1173 DCGCTHNG-RYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWAT 1231
             C C     RY P ++++   +C+ RC C       C A  CP    C      R     
Sbjct: 879  LCPCQLGARRYAPGSATM--KECN-RCICQERGLWNCTARHCPSQAFC-----PRELVYA 930

Query: 1232 RGLCVL---SVGANLTTFDGAR-GATTSPGVYELSSRC--PGL---QNTIPWYRVVAEVQ 1282
             G C+L   S  AN +   G+  G    PG   L  RC  P L   +++  WY   A +Q
Sbjct: 931  PGACLLTCDSPSANHSCPAGSTDGCVCPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQ 990

Query: 1283 ------ICH------------GKTEAVGQVHIFFQDGMVTLTP----------------- 1307
                  +C             G+ +A G  H    DG+    P                 
Sbjct: 991  EDCNVCVCRGRQWHCTGQRRSGRCQASGAPHYVTFDGLAFTYPGACEYLLVREASGLFTV 1050

Query: 1308 -------------------------------NKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                                            + V VNG+ V  P          R    
Sbjct: 1051 SAQNLPCGASGLTCTKALAVRLEGTVVHMLRGRAVTVNGVSVTPPKVYTGPGLSLRRAGL 1110

Query: 1337 SLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQ------EKP 1390
             LL+    G+ +      +V V +S    G++ G CG+FDGD +ND    Q       + 
Sbjct: 1111 FLLLSTHLGLTLLWDGGTRVLVQLSPQFRGRVAGLCGDFDGDASNDLRSRQGVLEPTAEL 1170

Query: 1391 AMEKWRAQDFSP 1402
            A   WR     P
Sbjct: 1171 AAHSWRLSPLCP 1182



 Score =  164 bits (414), Expect = 7e-40
 Identities = 130/420 (30%), Positives = 177/420 (42%), Gaps = 40/420 (9%)

Query: 45   DPCHGVTCRPQET-CKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLAT 103
            + C+   CR ++  C  Q   G C  +        G PHY +FDG  F + G C Y+L  
Sbjct: 991  EDCNVCVCRGRQWHCTGQRRSGRCQAS--------GAPHYVTFDGLAFTYPGACEYLLVR 1042

Query: 104  TGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLT 163
                     GL  FTV+ +N   G   ++  + + V   GT + + +     V VNGV  
Sbjct: 1043 ------EASGL--FTVSAQNLPCGASGLTCTKALAVRLEGTVVHMLRGRA--VTVNGVSV 1092

Query: 164  ALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRN 223
              P       +S+ +     LL    GL + +D   RV V L   + G V GLCG+ D +
Sbjct: 1093 TPPKVYTGPGLSLRRAGLFLLLSTHLGLTLLWDGGTRVLVQLSPQFRGRVAGLCGDFDGD 1152

Query: 224  PNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCP-TCPEDRLEQYEGPGFCGP 282
             +ND     G L P+  +   SWR     PLC +   G  P  C  +          CG 
Sbjct: 1153 ASNDLRSRQGVLEPTAELAAHSWRL---SPLCPEP--GDLPHPCTMNTHRAGWARARCGA 1207

Query: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGVVIE 340
            L       FT CHA VPP+  ++ C+ D   C  GGD + LC A+A+Y   C   G  + 
Sbjct: 1208 LLQPL---FTLCHAEVPPQQHYEWCLYDACGCDSGGDCECLCSAIATYADECARHGHHVR 1264

Query: 341  DWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSAD 400
             WR+Q  C + C     YE CGP CP +C    P          CVEGC C  G +L   
Sbjct: 1265 -WRSQELCSLQCEGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLLHGG 1323

Query: 401  RCVPLNNGCGC-WANGTYHEAGSEFWAD-GTCS----QWCRCGPGGGSLVCTPASCGLGE 454
             C+     C C W   ++   GS    D G C+    QW  CG  GG       +C  GE
Sbjct: 1324 ACLE-PASCPCEWGRNSF-PPGSVLQKDCGNCTCQEGQW-HCGGDGGHCEELVPACAEGE 1380



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 41/123 (33%), Positives = 48/123 (39%), Gaps = 13/123 (10%)

Query: 736  PLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCL 795
            P  CP    +  C    P SC  LSAP G    C  GC C +G +L  + CVP   C C 
Sbjct: 3087 PGMCPRDKQWLDCAQG-PASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCA 3145

Query: 796  HDGRYYPLGEVFYPGPECERRCECGPG-----GHVTCQEG----AACGPHEECRLEDGVQ 846
            H+G  YP G        CE  C C  G         C EG    +   P  +C    G  
Sbjct: 3146 HEGHLYPPGSTVV--RPCE-NCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPA 3202

Query: 847  ACH 849
             CH
Sbjct: 3203 RCH 3205



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 35/99 (35%), Positives = 42/99 (42%), Gaps = 3/99 (3%)

Query: 1118 PLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCT 1177
            P  CP    +  C +    SCA LS   G    C  GC C    LL   VC+P QDC C 
Sbjct: 3087 PGMCPRDKQWLDCAQG-PASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCA 3145

Query: 1178 HNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            H G   P  S+++     E CSC S     C +  C  G
Sbjct: 3146 HEGHLYPPGSTVVRP--CENCSCVSGLIANCSSWPCAEG 3182



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 65/212 (30%), Positives = 77/212 (36%), Gaps = 56/212 (26%)

Query: 244  GSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESF 303
            G+W    W+   W  C  SC    + R      P       P  GG      A  P  S 
Sbjct: 2556 GAWAM--WE--AWGPCSVSCGGGHQSRQRSCVDP------PPKNGG------APCPGASQ 2599

Query: 304  FKG-CVLDVCMGGGDHDILCKALASYVAA--CQAAGVVIEDWRAQVGCEITCPENSHYEV 360
             +  C L  C GG D    C+    YV+A  CQ   V                       
Sbjct: 2600 ERAPCGLQPCSGGTD----CELGRVYVSADLCQKGLV----------------------- 2632

Query: 361  CGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEA 420
              PPCP SC  P    +   C G CVEGC+C  G +L   RC+PL+  C C         
Sbjct: 2633 --PPCPPSCLDPKANRS---CSGHCVEGCRCPPGLLLHDTRCLPLSE-CPCLVGEELKWP 2686

Query: 421  GSEFWADGTCSQWCRCGPGGGSLVCTPASCGL 452
            G  F   G CSQ C C    G L+C P  C L
Sbjct: 2687 GVSFLL-GNCSQ-CVCEK--GELLCQPGGCPL 2714



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 65/227 (28%), Positives = 83/227 (36%), Gaps = 40/227 (17%)

Query: 248  APGWDPLCWDECRGSCPT-----CPEDRLEQYE-GPGFCG-PLAPGTGGPFTTCHAHVPP 300
            APG  P  W      CP+     CP D  ++    P  C  P   G   P++TC A    
Sbjct: 2790 APGGGP-GWRSRSRLCPSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAP--- 2845

Query: 301  ESFFKGCVLDVCMGG-GDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHY- 358
                       C GG       C +LA     C        D   Q  C   CPEN  + 
Sbjct: 2846 -----------CDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQP-CTAQCPENMLFR 2893

Query: 359  --EVC---GPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWA 413
              E C   G PCP  C +  P      C G C  GC C  G  L    C+P  + C C  
Sbjct: 2894 SAEQCHQEGGPCPRLCLTQGP---GIECTGFCAPGCTCPPGLFLHNASCLP-RSQCPCQL 2949

Query: 414  NGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLP 460
            +G  + +G+    D +C+  C C    G + CT   C +   CG  P
Sbjct: 2950 HGQLYASGAMARLD-SCNN-CTC--VSGKMACTSERCPV--ACGWSP 2990



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 66/241 (27%), Positives = 81/241 (33%), Gaps = 44/241 (18%)

Query: 242  WGGSWRAPGWDPLC-WDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP- 299
            W  +   P W P   W +C  SC      R  ++          P T  P        P 
Sbjct: 3177 WPCAEGEPTWSPWTPWSQCSASCGPA---RCHRHRFCARSPSAVPSTVAPLPLPATPTPL 3233

Query: 300  ---PESFFKGCVLDVCMGGGDHDIL-----CK-----ALASYVAAC-----QAAGVVIED 341
               PE+  + C+L  C   G          C       L S   AC     Q  G   E 
Sbjct: 3234 CSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEG 3293

Query: 342  WRAQ--VGCEITCP-------ENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCD 392
             RAQ  V   + CP       E + Y  CGPPCP SC           C   C  GC C 
Sbjct: 3294 PRAQGEVCQALPCPVTNCTAIEGAEYSPCGPPCPRSCDDLVH------CVWRCQPGCYCP 3347

Query: 393  AGFVLSADRCVPLNNG-CGC--WANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPAS 449
             G VLS++  + +  G C C     G  H  G+       C+  C C    G L CT   
Sbjct: 3348 PGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNH-CTCLE--GRLNCTDLP 3404

Query: 450  C 450
            C
Sbjct: 3405 C 3405



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 65/257 (25%), Positives = 90/257 (35%), Gaps = 33/257 (12%)

Query: 212  AVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWG---GSWRAPGWDPLCWDECRGSCPTCPE 268
            A C +   +   P N    P+ T  P  P  G   G+     W P  W+ C  SC    +
Sbjct: 3913 ANCTMGDPLQERPCN---LPSCTELPVCPGPGCGAGNCSWTSWAP--WEPCSRSCGVGQQ 3967

Query: 269  DRLEQYEGPGFCGPLAPG-----TGGPFTTCHAHVPPESFFKGCVLDVC--MGGGDHDIL 321
             RL  Y  PG  G   P          F    A   P  + +      C    GG   + 
Sbjct: 3968 RRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLR 4027

Query: 322  CKALASYVAACQAAGVVIEDWRAQ----VGCEITCPENSHYEVCGPPCPASCPSPAPLTT 377
             ++ +S  +    A    E  +A+    + CE  CP       C   CP  C   + L  
Sbjct: 4028 SRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRC---SDLQE 4084

Query: 378  PAVCEGP--CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWC- 434
              VC+    C +GC+C  G +     CVP+ + C C       +A    WA G+  Q   
Sbjct: 4085 GIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGH-CDC------TDAQGHSWAPGSQHQDAC 4137

Query: 435  -RCGPGGGSLVCTPASC 450
              C    G L CT   C
Sbjct: 4138 NNCSCQAGQLSCTAQPC 4154



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 68/233 (29%), Positives = 81/233 (34%), Gaps = 57/233 (24%)

Query: 645  CVSKPCP------SPCTPEQQESFG-GPDAC----------GVISATDGPL----APCHG 683
            C S PC       SP TP  Q S   GP  C            + +T  PL     P   
Sbjct: 3174 CSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPL 3233

Query: 684  LVPPAQYFQGCLLDACQVQGHPGGLCP----------AVATYVAACQAAGAQ-LGEW--- 729
               P    + CLL  C   G  G   P           + +   AC     Q LG++   
Sbjct: 3234 CSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEG 3293

Query: 730  --RRPDFCP-LQCPAHS-------HYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGF 779
               + + C  L CP  +        Y  CG  CP SC  L     C   C+ GC C  G 
Sbjct: 3294 PRAQGEVCQALPCPVTNCTAIEGAEYSPCGPPCPRSCDDLVH---CVWRCQPGCYCPPGQ 3350

Query: 780  VLS--GDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEG 830
            VLS  G  CV  G C CL        G+  +PG    R   C    H TC EG
Sbjct: 3351 VLSSNGAICVQPGHCSCLD----LLTGQRHHPGARLARPDGC---NHCTCLEG 3396



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 37/126 (29%), Positives = 47/126 (37%), Gaps = 9/126 (7%)

Query: 1117 CPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTR--CFEGCECDDRFLLSQGVCIPVQDC 1174
            C   CPA      C   C   C+ L     C     C +GC C    L   G C+P+  C
Sbjct: 4058 CEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHC 4117

Query: 1175 GCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGL 1234
             CT    +     S     C+  CSC +   L+C A  CPP   C     A + W+    
Sbjct: 4118 DCTDAQGHSWAPGSQHQDACN-NCSCQAGQ-LSCTAQPCPPPTHC-----AWSHWSAWSP 4170

Query: 1235 CVLSVG 1240
            C  S G
Sbjct: 4171 CSHSCG 4176



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 61/243 (25%), Positives = 80/243 (32%), Gaps = 33/243 (13%)

Query: 626  AVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLV 685
            A GG P GW+   ++ C       CP   T E+  S   P  C        P+    GL 
Sbjct: 2790 APGGGP-GWR-SRSRLCPSPGDSSCPGDATQEEPCS---PPVC--------PVPSIWGLW 2836

Query: 686  PPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHY 745
             P            Q +G     C ++A     C    +Q  +      C  QCP +  +
Sbjct: 2837 APWSTCSAPCDGGIQTRGRS---CSSLAPGDTTCPGPHSQTRDCNTQP-CTAQCPENMLF 2892

Query: 746  ---ELC---GDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGR 799
               E C   G  CP  C +      C   C  GC C  G  L   +C+P  QC C   G+
Sbjct: 2893 RSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPRSQCPCQLHGQ 2952

Query: 800  YYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLAN 859
             Y  G +        R   C    + TC  G      E C +  G           C  N
Sbjct: 2953 LYASGAM-------ARLDSC---NNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCN 3002

Query: 860  GGI 862
             GI
Sbjct: 3003 VGI 3005



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 59/224 (26%), Positives = 77/224 (34%), Gaps = 40/224 (17%)

Query: 632  AGWQVGGAQGCG-ECVSKPC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPA 688
            A W++  AQ    +C +  C   S   P Q+    GP      SA     APC G     
Sbjct: 4732 ASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGP-----WSAWSSCSAPCGG----- 4781

Query: 689  QYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELC 748
                G +      +G PG         VA CQA   +  +      CP +CP       C
Sbjct: 4782 ----GTMERHRTCEGGPG---------VAPCQAQDTEQRQECNLQPCP-ECPPGQVLSAC 4827

Query: 749  GDSCPVSCPSLSAPEGC-ESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPL---- 803
              SCP  C  L     C +  C+ GC C  G +L   TCVP   C C      + L    
Sbjct: 4828 ATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTACPCTQHSLPWGLTLTL 4887

Query: 804  ---GEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
                +   PG    R C         C  GA      +C++  G
Sbjct: 4888 EEQAQELPPGTVLTRNCT-----RCVCHGGAFSCSLVDCQVPPG 4926



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 27/81 (33%), Positives = 33/81 (40%), Gaps = 2/81 (2%)

Query: 1134 CQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSD 1193
            C  SC        C+  C EGC C    LL    C+P+ +C C           S L  +
Sbjct: 2635 CPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGN 2694

Query: 1194 CSERCSCSSSSGLTCQAAGCP 1214
            CS+ C C     L CQ  GCP
Sbjct: 2695 CSQ-CVCEKGE-LLCQPGGCP 2713



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 58/233 (24%), Positives = 75/233 (32%), Gaps = 55/233 (23%)

Query: 652  SPCTPE--------QQESFGGPDACGVISATD--GPLAPCHGLVPPAQYFQGCLLDACQV 701
            +PCT E        Q+E+      C V  A    GP +PC   +  +   + C       
Sbjct: 3445 APCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPE 3504

Query: 702  QGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSA 761
             G P   CP   T    CQ    Q  +          C        CG  CP SC  LS 
Sbjct: 3505 GGRP---CPGNHTQSRPCQENSTQCTD----------CGGGQSLHPCGQPCPRSCQDLSP 3551

Query: 762  PEGCESA---CREGCVCDAGFVLSGDTCVPVGQCGCLHD--------------GRYYPLG 804
               C+     C+  C C  G +     CVP   C C +               G  +   
Sbjct: 3552 GSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSW 3611

Query: 805  EVFYPGP----ECERRCECGPGGHVTCQEGAAC---------GPHEECRLEDG 844
            E   PG      C+  C C   G + CQE   C         GP E+C +  G
Sbjct: 3612 ESLEPGEVVTGPCD-NCTC-VAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCG 3662



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 31/110 (28%), Positives = 42/110 (38%), Gaps = 12/110 (10%)

Query: 735  CPLQCPAHSHYELCGDSCPVSCPSLSAPEGCES--ACREGCVCDAGFVLSGDTCVPVGQC 792
            C   CPA      C + CP  C  L     C+    C++GC C  G +     CVP+G C
Sbjct: 4058 CEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHC 4117

Query: 793  GCLHDGRYYPLGEVFYPGPECE---RRCECGPGGHVTCQEGAACGPHEEC 839
             C         G  + PG + +     C C   G ++C     C P   C
Sbjct: 4118 DCTD-----AQGHSWAPGSQHQDACNNCSC-QAGQLSC-TAQPCPPPTHC 4160



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 41/133 (30%), Positives = 50/133 (37%), Gaps = 6/133 (4%)

Query: 365  CPASCPSPAPLTTPAVCEGPCVEGCQCDAG-FVLSADRCVPLNNGCGCWANGTYHEAGSE 423
            C  +C       T + C      GC C  G F   A  CVP ++ C CW  G  H  GSE
Sbjct: 4940 CEQTCLEMNATKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDH-CECWHLGRPHLPGSE 4998

Query: 424  FWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYV 483
             W +   S  C  G    +  C+P +C  GE   L P     C P    E      P   
Sbjct: 4999 -WQEACESCLCLSGRPVCTQHCSPLTCAQGEEMVLEPG---SCCPSCRREAPEEQSPSCQ 5054

Query: 484  TLDGHRFDFQGTC 496
             L   R   +GTC
Sbjct: 5055 LLTELRNFTKGTC 5067



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 27/77 (35%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 752  CPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGP 811
            CP SC    A   C   C EGC C  G +L    C+P+ +C CL        G  F  G 
Sbjct: 2635 CPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGN 2694

Query: 812  ECERRCE-----CGPGG 823
              +  CE     C PGG
Sbjct: 2695 CSQCVCEKGELLCQPGG 2711



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/130 (26%), Positives = 47/130 (36%), Gaps = 9/130 (6%)

Query: 1091 CRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQ--GSCAALSGLTG-- 1146
            C SLA     C       +   T   C   CP +  +    +  Q  G C  L    G  
Sbjct: 2857 CSSLAPGDTTCPGPHSQTRDCNTQP-CTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPG 2915

Query: 1147 --CTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSS 1204
              CT  C  GC C     L    C+P   C C  +G+ L  + ++   D    C+C S  
Sbjct: 2916 IECTGFCAPGCTCPPGLFLHNASCLPRSQCPCQLHGQ-LYASGAMARLDSCNNCTCVSGK 2974

Query: 1205 GLTCQAAGCP 1214
             + C +  CP
Sbjct: 2975 -MACTSERCP 2983



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 36/126 (28%), Positives = 48/126 (38%), Gaps = 13/126 (10%)

Query: 1099 AACQAAGVAVKPWRTDSF----CPLHCPAHSHYSI--CTRTCQGSCAALSGLTGCTTR-C 1151
            A     G   +PW  +S     CP  C A        C   C  SCA L     C    C
Sbjct: 4642 AEALCGGGCREPWAQESCNGGPCP-ECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPC 4700

Query: 1152 FEGCECDDRFLLSQGVCIPVQDCGC---THNGRYLPVNSSLLTSDCSERCSCSSSSGLTC 1208
              GC C    L+  G C+P+  C C   + N  +    +  +  DC + C+C + S L C
Sbjct: 4701 RPGCRCPPGQLVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDC-QNCTCVNES-LVC 4758

Query: 1209 QAAGCP 1214
                CP
Sbjct: 4759 PHQECP 4764



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/194 (25%), Positives = 65/194 (33%), Gaps = 31/194 (15%)

Query: 1099 AACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTR-CFEGCEC 1157
            A CQA     +       CP  CP     S C  +C   C  L     C    C  GC C
Sbjct: 4797 APCQAQDTEQRQECNLQPCP-ECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGC 4855

Query: 1158 DDRFLLSQGVCIPVQDCGCTHN-------------GRYLPVNSSLLTSDCSERCSCSSSS 1204
                LL  G C+P   C CT +              + LP   ++LT +C+ RC C   +
Sbjct: 4856 PGGQLLHNGTCVPPTACPCTQHSLPWGLTLTLEEQAQELP-PGTVLTRNCT-RCVCHGGA 4913

Query: 1205 GLTCQAAGC--PPGR-----------VCEVKAEARNCWATRGLCVLSVGANLTTFDGARG 1251
              +C    C  PPG            +CE      N   T+  C  +  +      G   
Sbjct: 4914 -FSCSLVDCQVPPGETWQQVAPGELGLCEQTCLEMNATKTQSNCSSARASGCVCQPGHFR 4972

Query: 1252 ATTSPGVYELSSRC 1265
            +   P V E    C
Sbjct: 4973 SQAGPCVPEDHCEC 4986



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 35/102 (34%), Positives = 41/102 (40%), Gaps = 15/102 (14%)

Query: 752  CPVSCPSLSAPE---GCESACREGCVCDAG-FVLSGDTCVPVGQCGCLHDGRYYPLGEVF 807
            C  +C  ++A +    C SA   GCVC  G F      CVP   C C H      LG   
Sbjct: 4940 CEQTCLEMNATKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDHCECWH------LGRPH 4993

Query: 808  YPGPECERRCE---CGPGGHVTCQEGA--ACGPHEECRLEDG 844
             PG E +  CE   C  G  V  Q  +   C   EE  LE G
Sbjct: 4994 LPGSEWQEACESCLCLSGRPVCTQHCSPLTCAQGEEMVLEPG 5035



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 34/115 (29%), Positives = 44/115 (38%), Gaps = 13/115 (11%)

Query: 349  EITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG--PCVEGCQCDAGFVLSADRCVPLN 406
            E +C     +  CG PC   C   A   +  +C+   PC  GC C  G +  A  C+P  
Sbjct: 4420 EDSCTPPFEFHACGSPCAGLC---ATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPE 4476

Query: 407  NGCGCWANGTYHEAGSEFWADGTCSQWCR-CGPGGGSLVCTPASCGLGEVCGLLP 460
              C CW + +   AG            C+ C    G L CT   C      GLLP
Sbjct: 4477 E-CNCW-HTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQ-----GLLP 4524



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 51/222 (22%), Positives = 68/222 (30%), Gaps = 73/222 (32%)

Query: 645  CVSKPCPSPCT---------------PEQQESFGGPDACGVISATDGPLAPCHGLVPPAQ 689
            C S PCP  C                 +Q+    GP + G  +      APC  L     
Sbjct: 4357 CYSGPCPEECVWSSWSSWTRCSCRVLVQQRYRHQGPASRGARAG-----APCTRL---DG 4408

Query: 690  YFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCG 749
            +F+ CL+  C          P    +      AG               C  H  ++LC 
Sbjct: 4409 HFRPCLISNCS----EDSCTPPFEFHACGSPCAGL--------------CATHLSHQLCQ 4450

Query: 750  DSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYP 809
            D  P               C+ GC C  G +     C+P  +C C H       G    P
Sbjct: 4451 DLPP---------------CQPGCYCPKGLLEQAGGCIPPEECNCWHTSA-AGAGMTLAP 4494

Query: 810  GPECE---RRCECGPGG-HVTCQ------------EGAACGP 835
            G   +   + CEC  G  H T Q            E + CGP
Sbjct: 4495 GDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGP 4536



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 42/152 (27%), Positives = 56/152 (36%), Gaps = 24/152 (15%)

Query: 329  VAACQAAGVVIEDWRAQVGCEIT----CPENSHYEVCGPPCPASCPSPAPLTTPAVC-EG 383
            VA CQA     +D   +  C +     CP       C   CP  C    P    A+C + 
Sbjct: 4796 VAPCQA-----QDTEQRQECNLQPCPECPPGQVLSACATSCPCLCWHLQP---GAICVQE 4847

Query: 384  PCVEGCQCDAGFVLSADRCVPLNNGCGCWANG-------TYHEAGSEFWADGTCSQWC-R 435
            PC  GC C  G +L    CVP    C C  +        T  E   E       ++ C R
Sbjct: 4848 PCQPGCGCPGGQLLHNGTCVP-PTACPCTQHSLPWGLTLTLEEQAQELPPGTVLTRNCTR 4906

Query: 436  CGPGGGSLVCTPASCGL--GEVCGLLPSGQHG 465
            C   GG+  C+   C +  GE    +  G+ G
Sbjct: 4907 CVCHGGAFSCSLVDCQVPPGETWQQVAPGELG 4938



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 14/96 (14%)

Query: 748  CGDSCPVSCPSLSAPEGC-ESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEV 806
            C + CP SC  L     C +  CR GC C  G ++    CVP+  C C       P    
Sbjct: 4678 CANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGRCVPISSCRC-----GLPSANA 4732

Query: 807  FY---PGPECERRCECGPGGHVTCQEGAACGPHEEC 839
             +   P    +  C+     + TC   +   PH+EC
Sbjct: 4733 SWELAPAQAVQLDCQ-----NCTCVNESLVCPHQEC 4763



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 41/121 (33%), Positives = 53/121 (43%), Gaps = 19/121 (15%)

Query: 340  EDWRAQVGCEI-TCPENSHYEV-----CGPPCPASCPSPAPLTTPAVC-EGPCVEGCQCD 392
            E W AQ  C    CPE    +      C   CP SC   A L     C +GPC  GC+C 
Sbjct: 4652 EPW-AQESCNGGPCPECEAQDTVFTLDCANQCPHSC---ADLWDRVQCLQGPCRPGCRCP 4707

Query: 393  AGFVLSADRCVPLNNGCGCW---ANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPAS 449
             G ++   RCVP+++ C C    AN ++  A ++  A     Q C C     SLVC    
Sbjct: 4708 PGQLVQDGRCVPISS-CRCGLPSANASWELAPAQ--AVQLDCQNCTC--VNESLVCPHQE 4762

Query: 450  C 450
            C
Sbjct: 4763 C 4763



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 147/647 (22%), Positives = 199/647 (30%), Gaps = 152/647 (23%)

Query: 645  CVSKPCPSP----CTPEQQ--ESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLL-- 696
            C  +PC  P    C  ++Q  +   GP +C  +SA  G    CH   P      G LL  
Sbjct: 3077 CGLQPCAGPVPGMCPRDKQWLDCAQGPASCAELSAPRGTNQTCH---PGCHCPSGMLLLN 3133

Query: 697  --------DACQVQGH---PGGL-------CPAVATYVAACQAAGAQLGE-----WRRPD 733
                      C  +GH   PG         C  V+  +A C +     GE     W    
Sbjct: 3134 NVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWS 3193

Query: 734  FCPLQC-PAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQ 791
             C   C PA  H +  C  S P + PS  AP    +     C   +G     + C+  G 
Sbjct: 3194 QCSASCGPARCHRHRFCARS-PSAVPSTVAPLPLPATPTPLC---SGPEAEEEPCLLQG- 3248

Query: 792  CGCLHDGRYYPLGEVFYPGPECERRCECGPGGHV-TCQEGAACGPHEECRLEDGVQA--- 847
              C   G + P G    P   C R C  G       C +    G  + C   +G +A   
Sbjct: 3249 --CDRAGGWGPWG----PWSHCSRSCGGGLRSRTRACDQPPPQGLGDYC---EGPRAQGE 3299

Query: 848  -CHATGCG--RCLANGGIHYITLDG---RVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK 901
             C A  C    C A  G  Y        R  D    C +     C+  PG      VL  
Sbjct: 3300 VCQALPCPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQ-----VLSS 3354

Query: 902  NAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLR 961
            N A  +Q    +     + L  GQ+    G  +A P          EGR   L  T    
Sbjct: 3355 NGAICVQPGHCSC----LDLLTGQRHH-PGARLARPDGCNHC-TCLEGR---LNCT---- 3401

Query: 962  LLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSS 1021
                        +P P  G  C         WS+ + + +        +   A   P   
Sbjct: 3402 -----------DLPCPVPGGWCP--------WSE-WTMCSQPCRGQTRSRSRACACPTPQ 3441

Query: 1022 KGCGEGCGPQGCPVCLAEETAPYESNEACGQLRN--------PQGPFATCQAVLSPSEYF 1073
             G     G  G       E       EAC             P GP++ C   L  S   
Sbjct: 3442 HGGAPCTGEAG-------EAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRS 3494

Query: 1074 RQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRT 1133
            R C      + G               C       +P + +S     C        C + 
Sbjct: 3495 RACSRPPTPEGG-------------RPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQP 3541

Query: 1134 CQGSCAALSGLTGC---TTRCFEGCECDDRFLLSQGVCIPVQDCGCTH--NGRYLPVNSS 1188
            C  SC  LS  + C   +  C   C C    L   G+C+P   C C +      +P N S
Sbjct: 3542 CPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQS 3601

Query: 1189 -----------------LLTSDCSERCSCSSSSGLTCQ-AAGCP-PG 1216
                             ++T  C + C+C +   L CQ    CP PG
Sbjct: 3602 RSAGSRFSSWESLEPGEVVTGPC-DNCTCVAGI-LQCQEVPDCPDPG 3646



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 58/252 (23%), Positives = 84/252 (33%), Gaps = 63/252 (25%)

Query: 620  PADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLA 679
            P +  ++ G + + W+   +   GE V+ PC + CT             G++   + P  
Sbjct: 3597 PENQSRSAGSRFSSWE---SLEPGEVVTGPCDN-CTC----------VAGILQCQEVPDC 3642

Query: 680  PCHGLVPPAQYFQGCLLDA----------CQVQGHPGGLCPAVATYVAACQAAGAQLGEW 729
            P  G+      ++ C +            C     PG    +       C+ AG      
Sbjct: 3643 PDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAG------ 3696

Query: 730  RRPDFCPLQCPAHSHYELC--GDSCPVSCPSLSAPEGCES-ACREGCVCDAGFVLSGDTC 786
                     CPA   Y  C  G+ CP SC  ++   GC S  C EGC C  G       C
Sbjct: 3697 ---------CPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLAC 3747

Query: 787  VPVGQC----------GCLHDGRYYPLGEVFYPGPECER----RCECGPGGHVTCQEGAA 832
            V    C          G        PLG    PG E +     R  C   G+ +C  G  
Sbjct: 3748 VQECPCVLTAWLLQELGATIGDPGQPLG----PGDELDSGQTLRTSC---GNCSCAHGKL 3800

Query: 833  CGPHEECRLEDG 844
                ++C   DG
Sbjct: 3801 SCSLDDCFEADG 3812



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 38/140 (27%), Positives = 53/140 (37%), Gaps = 28/140 (20%)

Query: 1123 AHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ-GVCIPVQDCGCTHNGR 1181
            A     +C +TC     A    + C++    GC C      SQ G C+P   C C H GR
Sbjct: 4933 APGELGLCEQTCL-EMNATKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDHCECWHLGR 4991

Query: 1182 -YLP-------VNSSLLTSD---CSERCS---CSSSSGLTCQAAGCPP----------GR 1217
             +LP         S L  S    C++ CS   C+    +  +   C P            
Sbjct: 4992 PHLPGSEWQEACESCLCLSGRPVCTQHCSPLTCAQGEEMVLEPGSCCPSCRREAPEEQSP 5051

Query: 1218 VCEVKAEARNCWATRGLCVL 1237
             C++  E RN   T+G C L
Sbjct: 5052 SCQLLTELRN--FTKGTCYL 5069



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 37/132 (28%), Positives = 45/132 (34%), Gaps = 28/132 (21%)

Query: 352  CPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGC 411
            CP +  +  C    PASC   A L+ P      C  GC C +G +L  + CVP  + C C
Sbjct: 3090 CPRDKQWLDCAQG-PASC---AELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQD-CPC 3144

Query: 412  WANGTYHEAGSEFWAD-----------GTCSQWCRCGPGGG-----------SLVCTPAS 449
               G  +  GS                  CS W  C  G             S  C PA 
Sbjct: 3145 AHEGHLYPPGSTVVRPCENCSCVSGLIANCSSW-PCAEGEPTWSPWTPWSQCSASCGPAR 3203

Query: 450  CGLGEVCGLLPS 461
            C     C   PS
Sbjct: 3204 CHRHRFCARSPS 3215



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 34/111 (30%), Positives = 43/111 (38%), Gaps = 12/111 (10%)

Query: 1117 CPL-HCPA--HSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVCIPV 1171
            CP+ +C A   + YS C   C  SC     L  C  RC  GC C    +LS    +C+  
Sbjct: 3306 CPVTNCTAIEGAEYSPCGPPCPRSC---DDLVHCVWRCQPGCYCPPGQVLSSNGAICVQP 3362

Query: 1172 QDCGCTH--NGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCP-PGRVC 1219
              C C     G+     + L   D    C+C     L C    CP PG  C
Sbjct: 3363 GHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGR-LNCTDLPCPVPGGWC 3412



 Score = 40.0 bits (92), Expect = 0.016
 Identities = 60/231 (25%), Positives = 79/231 (34%), Gaps = 52/231 (22%)

Query: 634  WQVGGAQGC---GECVSKPCPSPCTPEQQESFGGPDACGVIS--ATDGPLA----PCHGL 684
            W  G ++ C   G  V + CP P   E Q       AC V    +T  P +    PC G 
Sbjct: 1713 WGQGRSRRCSPLGLLVLQNCPGP---EHQSQACFTAACPVDGEWSTWSPWSVCSEPCRGT 1769

Query: 685  VPPAQYFQGCLLDACQVQGHPGGL--------CPAVATYVAACQAAGAQLGEWRRPDFCP 736
            +   +               PGGL        CP      A C  +G  + +   P  CP
Sbjct: 1770 MTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDGCPNATC--SGELMFQPCAP--CP 1825

Query: 737  LQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD-TCVPVGQCGCL 795
            L C   S    C    P   P              GC C  G VL  +  CV   QC CL
Sbjct: 1826 LTCDDISGQVTCPPDWPCGSP--------------GCWCPEGQVLGSEGWCVWPRQCPCL 1871

Query: 796  HDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEG--AACGPHEECRLEDG 844
             DG  Y      +PG   +  C+        CQ+G    C  + +C ++ G
Sbjct: 1872 VDGARY------WPGQRIKADCQL-----CICQDGRPRRCRLNPDCAVDCG 1911



 Score = 40.0 bits (92), Expect = 0.016
 Identities = 30/100 (30%), Positives = 34/100 (34%), Gaps = 10/100 (10%)

Query: 1121 CPAHSHYSICTRTCQGSCAALSGLTGCTTR--CFEGCECDDRFLLSQGVCIPVQDCGCTH 1178
            C     +  C   C G CA       C     C  GC C    L   G CIP ++C C H
Sbjct: 4423 CTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNCWH 4482

Query: 1179 N-----GRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGC 1213
                  G  L     L    C E C C     L C + GC
Sbjct: 4483 TSAAGAGMTLAPGDRLQLG-CKE-CECRRGE-LHCTSQGC 4519



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 65/269 (24%), Positives = 86/269 (31%), Gaps = 72/269 (26%)

Query: 259  CRGSCP-TCPEDR--LEQYEGPGFCGPLAPGTGGPFTTCH--AHVPPESFFKGCVL--DV 311
            C G  P  CP D+  L+  +GP  C  L+    G   TCH   H P      G +L  +V
Sbjct: 3082 CAGPVPGMCPRDKQWLDCAQGPASCAELS-APRGTNQTCHPGCHCP-----SGMLLLNNV 3135

Query: 312  CMGGGDHDIL------------------CKALASYVAACQA-----AGVVIEDWRAQVGC 348
            C+   D                      C  ++  +A C +            W     C
Sbjct: 3136 CVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQC 3195

Query: 349  EITC-PENSHYEVCGPPCPASCPS-----PAPLTTPAVCEGPCVEGCQCDAGFVLSADRC 402
              +C P   H        P++ PS     P P T   +C GP  E   C    +   DR 
Sbjct: 3196 SASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPC---LLQGCDRA 3252

Query: 403  VPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCT-PASCGLG-------- 453
                 G G W   ++            CS+ C  G    +  C  P   GLG        
Sbjct: 3253 ----GGWGPWGPWSH------------CSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRA 3296

Query: 454  --EVCGLLPSGQHGCQPVSTAECQAWGDP 480
              EVC  LP     C  +  AE    G P
Sbjct: 3297 QGEVCQALPCPVTNCTAIEGAEYSPCGPP 3325



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 34/117 (29%), Positives = 44/117 (37%), Gaps = 15/117 (12%)

Query: 345  QVGC-EITCPENSHYEVCGPPCPASCPS-PAPLTTPAVCEGPCVE-GCQCDAGFVLSADR 401
            Q GC   TC     ++ C P CP +C      +T P   + PC   GC C  G VL ++ 
Sbjct: 1804 QDGCPNATCSGELMFQPCAP-CPLTCDDISGQVTCPP--DWPCGSPGCWCPEGQVLGSEG 1860

Query: 402  CVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGL 458
                   C C  +G  +  G    AD    Q C C  G       P  C L   C +
Sbjct: 1861 WCVWPRQCPCLVDGARYWPGQRIKAD---CQLCICQDG------RPRRCRLNPDCAV 1908



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 33/124 (26%), Positives = 44/124 (35%), Gaps = 27/124 (21%)

Query: 1058 GPFATCQAVLSPSEYFR--QCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDS 1115
            GP+  C       E  R  +C    C     ++  C      T  C+ AG          
Sbjct: 3652 GPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCS-----TQVCREAG---------- 3696

Query: 1116 FCPLHCPAHSHYSICT--RTCQGSCAALSGLTGCTTR-CFEGCECDDRFLLSQGVCIPVQ 1172
                 CPA   Y  C     C  SCA ++   GC +  C EGC C +     +  C  VQ
Sbjct: 3697 -----CPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLAC--VQ 3749

Query: 1173 DCGC 1176
            +C C
Sbjct: 3750 ECPC 3753



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 36/148 (24%), Positives = 45/148 (30%), Gaps = 29/148 (19%)

Query: 260  RGSCP---TCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGG 316
            R +CP   TCP D        G  GP      GP++ C   +      + C       GG
Sbjct: 3460 REACPSYATCPVD--------GAWGPW-----GPWSPCDMCLGQSHRSRACSRPPTPEGG 3506

Query: 317  DHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLT 376
                 C    +    CQ       D          C        CG PCP SC   +P +
Sbjct: 3507 RP---CPGNHTQSRPCQENSTQCTD----------CGGGQSLHPCGQPCPRSCQDLSPGS 3553

Query: 377  TPAVCEGPCVEGCQCDAGFVLSADRCVP 404
                    C   C C  G +     CVP
Sbjct: 3554 VCQPGSVGCQPTCGCPLGQLSQDGLCVP 3581



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 25/63 (39%), Positives = 26/63 (41%), Gaps = 8/63 (12%)

Query: 345  QVGCEITCPENSHYEVCGPP--CPASCPSPAPLTTPAVC--EGPCVEGCQCDAGFVLSAD 400
            QV  E  CP    Y  C P   CP SC   A +T    C  EG C EGC C  G      
Sbjct: 3690 QVCREAGCPAGRLYRECQPGEGCPFSC---AHVTQQVGCFSEG-CEEGCHCPEGTFQHRL 3745

Query: 401  RCV 403
             CV
Sbjct: 3746 ACV 3748


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score =  355 bits (912), Expect = 1e-97
 Identities = 341/1316 (25%), Positives = 490/1316 (37%), Gaps = 218/1316 (16%)

Query: 75   CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
            C  WGD HY +FDG  F F G CNYV +              F V  +    G+  V  V
Sbjct: 77   CSTWGDFHYKTFDGDVFRFPGLCNYVFSEH-----CRAAYEDFNVQLRRGLVGSRPV--V 129

Query: 135  RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVS 194
              V + A G  +       G V +NG    LP S    R  +    S   +     L ++
Sbjct: 130  TRVVIKAQGLVLEASN---GSVLINGQREELPYS----RTGLLVEQSGDYIKVSIRLVLT 182

Query: 195  YDWNWRVD--VTLPSSYHGAVCGLCGNMDRNPNNDQVFP-NGTLAPSIPIWGGSWRAPGW 251
            + WN      + L   Y    CGLCG+ +  P  ++ +  N  L P    +G   +  G 
Sbjct: 183  FLWNGEDSALLELDPKYANQTCGLCGDFNGLPAFNEFYAHNARLTPLQ--FGNLQKLDGP 240

Query: 252  DPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV 311
               C D        C ++        G C     G    F  CHA V   ++   C  D+
Sbjct: 241  TEQCPDPLPLPAGNCTDEE-------GICHRTLLGPA--FAECHALVDSTAYLAACAQDL 291

Query: 312  CMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPS 371
            C         C     Y   C  AG    +WR    C  TCP N  ++ CG PC  +C +
Sbjct: 292  CRCP---TCPCATFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSN 348

Query: 372  PAPLTTPAVCEGPCVEGCQCDAGFV------LSADRCVPLNNGCGCWANGTYHEAGSEFW 425
            P       +CE  CV+GC C  G        ++   C+PL   C C   G  +  G+ F 
Sbjct: 349  P---QRAQLCEDHCVDGCFCPPGRSCTVLDDITHSGCLPLGQ-CPCTHGGRTYSPGTSF- 403

Query: 426  ADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTL 485
             + TCS  C C   GG   C    C                       C   G  H  T 
Sbjct: 404  -NTTCSS-CTC--SGGLWQCQDLPC--------------------PGTCSVQGGAHISTY 439

Query: 486  DGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTLQIYNHSLT 544
            D   +D  G C Y+LS  C        +FTV       G +   +  ++VTL +      
Sbjct: 440  DEKLYDLHGDCSYVLSKKC-----ADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTA 494

Query: 545  LSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVR--LRVP 602
            +  +    + ++ ++  LP    ++     S   +VV T  GL L       ++  +R+ 
Sbjct: 495  IRVQADGGVFLNSIYTQLPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLD 554

Query: 603  AAYAASLCGLCGNYNQDPADDLKAVGG-----KPAGWQVGGAQGCGECVSKPCPSPCTPE 657
             A+   +CGLCGN+NQ+ ADD  A+ G       A      AQ            PC+  
Sbjct: 555  PAHQGQMCGLCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLS 614

Query: 658  QQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVA 717
             +        C  ++  +   + CH ++ P  +   C+ D C  +     LC A+++YV 
Sbjct: 615  VENENYARHWCSRLTDPNSAFSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVH 674

Query: 718  ACQAAGAQLGEWRRPDFCP---LQCPAHSHYELCGDSCPVSCPSLSAPEGCESAC---RE 771
            AC A G QL +W R   C      CP    Y    D+C  +C  LS  +   S      +
Sbjct: 675  ACAAKGVQLSDW-RDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADVTCSVSFVPVD 733

Query: 772  GCVCDAG-FVLSGDTCVPVGQCGCLHDGRYYPLGEVFY---------------------- 808
            GC C AG F+     CVP  +C C   G     GEV +                      
Sbjct: 734  GCTCPAGTFLNDAGACVPAQECPCYAHGTVLAPGEVVHDEGAVCSCTGGKLSCLGASLQK 793

Query: 809  --------------------PGPECERRCE----------------CGPG------GHVT 826
                                PG EC R C                 C PG      G   
Sbjct: 794  STGCAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI 853

Query: 827  CQEGAAC-------GPHEECRLEDGVQAC--------HATGCGRCLANGGIHYITLDGRV 871
             +E   C        P E  R++     C        H    G C+A G  H+IT DG  
Sbjct: 854  AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDR 913

Query: 872  YDLHGSCSYVLAQ-VCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD 930
            Y   GSC Y+LAQ  C        F IV E    G       T   + + L       + 
Sbjct: 914  YSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTG----TTCSKAIKLFVESYELIL 969

Query: 931  GEAVALPVAVG-----RVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGL 985
             E     VA G       ++   G  +V++ T G+ + +D    + + +   ++GR+CGL
Sbjct: 970  QEGTFKAVARGPGGDPPYKIRYMGIFLVIE-THGMAVSWDRKTSVFIRLHQDYKGRVCGL 1028

Query: 986  CGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYE 1045
            CGNF+ N  +DF   + S       FG +W++   S  C +   P+    C A       
Sbjct: 1029 CGNFDDNAINDFATRSRSVVGDALEFGNSWKL---SPSCPDALAPK--DPCTANPFRKSW 1083

Query: 1046 SNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTAACQA 1103
            + + C  L  P   FA C++ +  ++Y+  CV D CA    GD    C ++AAY  AC  
Sbjct: 1084 AQKQCSILHGP--TFAACRSQVDSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHD 1141

Query: 1104 AGVAVKPWRTDSFCPLHCPAHS-------HYSICTRTCQGSC--------AALSGLTGCT 1148
            AG+ V  WRT   CPL C  ++       HY  C   C  +C          L GL GC 
Sbjct: 1142 AGLCVS-WRTPDTCPLFCDFYNPHGGCEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCY 1200

Query: 1149 TRCFEGCECDDRFLLSQGVCIPVQDCGC-THNGRYLPVNSSLLTSDCSERCSCSSSSGLT 1207
             +C         F   Q  C  V  CGC   +G Y  V + + T++  + C+C + SG+ 
Sbjct: 1201 PKC---PPSQPFFNEDQMKC--VAQCGCYDKDGNYYDVGARVPTAENCQSCNC-TPSGIQ 1254

Query: 1208 C----QAAGCP-PGRVCEVKAEARNCWATRGLCVLSV-GANLTTFDGARGATTSPG 1257
            C    +A  C    R    +    N     G C++++ G+N T     R A   PG
Sbjct: 1255 CAHSLEACTCTYEDRTYSYQDVIYNTTDGLGACLIAICGSNGTII---RKAVACPG 1307



 Score =  305 bits (781), Expect = 2e-82
 Identities = 282/1040 (27%), Positives = 397/1040 (38%), Gaps = 206/1040 (19%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 533
            C  WGD HY T DG  F F G C Y+ S  C       E+F V +     GS+ V  TR 
Sbjct: 77   CSTWGDFHYKTFDGDVFRFPGLCNYVFSEHCRA---AYEDFNVQLRRGLVGSRPV-VTRV 132

Query: 534  VTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
            V   I    L L A     L ++G    LP+    LL    SG  + V+    L+  ++G
Sbjct: 133  V---IKAQGLVLEASNGSVL-INGQREELPYSRTGLL-VEQSGDYIKVSIRLVLTFLWNG 187

Query: 594  DSFVRLRVPAAYAASLCGLCGNYNQDPA-DDLKAVGGKPAGWQVGGAQ---GCGECVSKP 649
            +    L +   YA   CGLCG++N  PA ++  A   +    Q G  Q   G  E    P
Sbjct: 188  EDSALLELDPKYANQTCGLCGDFNGLPAFNEFYAHNARLTPLQFGNLQKLDGPTEQCPDP 247

Query: 650  CPSP---CTPEQQESFGGPDACGVISATD-GP-LAPCHGLVPPAQYFQGCLLDACQVQGH 704
             P P   CT E+          G+   T  GP  A CH LV    Y   C  D C+    
Sbjct: 248  LPLPAGNCTDEE----------GICHRTLLGPAFAECHALVDSTAYLAACAQDLCRCPTC 297

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P   C     Y   C  AG Q   WR P+ CP  CP +  ++ CG  C  +C +    + 
Sbjct: 298  P---CATFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSNPQRAQL 354

Query: 765  CESACREGCVCDAG---FVLSGDT---CVPVGQCGCLHDGRYYPLGEVFYPGPECERRCE 818
            CE  C +GC C  G    VL   T   C+P+GQC C H GR Y  G  F           
Sbjct: 355  CEDHCVDGCFCPPGRSCTVLDDITHSGCLPLGQCPCTHGGRTYSPGTSF----------- 403

Query: 819  CGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHYITLDGRVYDLHGS 877
                 + TC           C    G+  C    C G C   GG H  T D ++YDLHG 
Sbjct: 404  -----NTTCSS---------CTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGD 449

Query: 878  CSYVLAQVCHPKPGDEDFSIVLEKNAAG--DLQRLLVTVAGQVVSLAQGQQVTVDGEA-- 933
            CSYVL++ C     D  F+++ E    G  D +  L  V   +       +V  DG    
Sbjct: 450  CSYVLSKKC----ADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGVFL 505

Query: 934  ----VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLFD--GDAHLLMSIPSPFRGRLCGLC 986
                  LP++   + + T     +V+QT  GL+LL        + + +    +G++CGLC
Sbjct: 506  NSIYTQLPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLC 565

Query: 987  GNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYES 1046
            GNFN N +DDF   +G   ++   F   W+   +   C         P  L+ E   Y +
Sbjct: 566  GNFNQNQADDFTALSGVVEATGAAFANTWKAQAA---CANARNSFEDPCSLSVENENY-A 621

Query: 1047 NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGV 1106
               C +L +P   F+ C ++++P  +   C++D C  +  +  LC +L++Y  AC A GV
Sbjct: 622  RHWCSRLTDPNSAFSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGV 681

Query: 1107 AVKPWRTDSFCPLH---CPAHSHYSICTRTCQGSCAALSGLTGCTTRC------FEGCEC 1157
             +  WR D  C  +   CP    Y+     CQ +C    GL+     C       +GC C
Sbjct: 682  QLSDWR-DGVCTKYMQNCPKSQRYAYVVDACQPTCR---GLSEADVTCSVSFVPVDGCTC 737

Query: 1158 D-DRFLLSQGVCIPVQD----------------------CGCTHNGRYLPVNSSLLTS-- 1192
                FL   G C+P Q+                      C CT  G+   + +SL  S  
Sbjct: 738  PAGTFLNDAGACVPAQECPCYAHGTVLAPGEVVHDEGAVCSCT-GGKLSCLGASLQKSTG 796

Query: 1193 --------DCSERCS--------------------------CSSSSGLTCQAAG------ 1212
                    DCS   +                          C    GL    +G      
Sbjct: 797  CAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCIAEE 856

Query: 1213 -CP---------PGRVCEVKAEARNCWATR---------GLCVLSVGANLTTFDGARGAT 1253
             CP         PG    V      C   R         G CV     +  TFDG R + 
Sbjct: 857  DCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSF 916

Query: 1254 TSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWV 1313
                 Y L+    G   T   +R+V E   C                G    T +K + +
Sbjct: 917  EGSCEYILAQDYCGDNTTHGTFRIVTENIPC----------------GTTGTTCSKAIKL 960

Query: 1314 NGLRVDLPAEKLASVSVSRTPDGS----------LLVRQKAGVQVWLGANGKVAVIVSND 1363
                 +L  ++    +V+R P G            LV +  G+ V       V + +  D
Sbjct: 961  FVESYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFIRLHQD 1020

Query: 1364 HAGKLCGACGNFDGDQTNDW 1383
            + G++CG CGNFD +  ND+
Sbjct: 1021 YKGRVCGLCGNFDDNAINDF 1040



 Score =  236 bits (603), Expect = 9e-62
 Identities = 250/958 (26%), Positives = 363/958 (37%), Gaps = 195/958 (20%)

Query: 43   SPDPCHGVTCRPQETCKEQGGQGVC--LPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYV 100
            SP      TC    +C   GG   C  LP    TC + G  H  ++D + +D  G C+YV
Sbjct: 398  SPGTSFNTTC---SSCTCSGGLWQCQDLP-CPGTCSVQGGAHISTYDEKLYDLHGDCSYV 453

Query: 101  LATTGCLGVSTQGLTPFTVT--TKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRV 158
            L+   C   S   L        T NEN        ++ VT++  G + +I     G V +
Sbjct: 454  LSKK-CADSSFTVLAELRKCGLTDNEN-------CLKAVTLSLDGGDTAIRVQADGGVFL 505

Query: 159  NGVLTALPVSVADGRISVAQGASKALLV-ADFGLQVSYDWN--WRVDVTLPSSYHGAVCG 215
            N + T LP+S A+  I++   +S  ++V    GLQ+        +V V L  ++ G +CG
Sbjct: 506  NSIYTQLPLSAAN--ITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCG 563

Query: 216  LCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYE 275
            LCGN ++N  +D    +G +  +   +  +W+A        +     C    E+  E Y 
Sbjct: 564  LCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLSVEN--ENY- 620

Query: 276  GPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335
               +C  L       F+ CH+ + P+ F   C+ D C      D LC AL+SYV AC A 
Sbjct: 621  ARHWCSRLTDPNSA-FSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVHACAAK 679

Query: 336  GVVIEDWRAQVGCEI--TCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDA 393
            GV + DWR  V  +    CP++  Y      C  +C   +            V+GC C A
Sbjct: 680  GVQLSDWRDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADVTCSVSFVPVDGCTCPA 739

Query: 394  G-FVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPAS--- 449
            G F+  A  CVP    C C+A+GT    G     +G       C   GG L C  AS   
Sbjct: 740  GTFLNDAGACVPAQE-CPCYAHGTVLAPGEVVHDEGAV-----CSCTGGKLSCLGASLQK 793

Query: 450  ----------------------------------------CGLGEVC--GLLPSGQHGCQ 467
                                                    C  G VC  GL+  G  GC 
Sbjct: 794  STGCAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI 853

Query: 468  PVSTAEC------------------------QAWGDPHYVTL--------------DGHR 489
                  C                        + W   H + L              DG R
Sbjct: 854  AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDR 913

Query: 490  FDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARW 549
            + F+G+CEY+L+    G       F +   N   G+   + ++++ L + ++ L L    
Sbjct: 914  YSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVESYELILQ--- 970

Query: 550  PRKLQVDGVFVAL--------PFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRV 601
                  +G F A+        P+++  +          +V  T G+++++D  + V +R+
Sbjct: 971  ------EGTFKAVARGPGGDPPYKIRYM-------GIFLVIETHGMAVSWDRKTSVFIRL 1017

Query: 602  PAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGEC--VSKPCP------SP 653
               Y   +CGLCGN++ +  +D            VG A   G    +S  CP       P
Sbjct: 1018 HQDYKGRVCGLCGNFDDNAINDFATRSRS----VVGDALEFGNSWKLSPSCPDALAPKDP 1073

Query: 654  CTPEQQESFGGPDACGVISATDGP-LAPCHGLVPPAQYFQGCLLDACQVQ--GHPGGLCP 710
            CT            C ++    GP  A C   V   +Y++ C+ DAC     G     C 
Sbjct: 1074 CTANPFRKSWAQKQCSIL---HGPTFAACRSQVDSTKYYEACVNDACACDSGGDCECFCT 1130

Query: 711  AVATYVAACQAAGAQLGEWRRPDFCPLQCPAHS-------HYELCGDSCPVSC--PS--- 758
            AVA Y  AC  AG  +  WR PD CPL C  ++       HY+ CG  C  +C  PS   
Sbjct: 1131 AVAAYAQACHDAGLCV-SWRTPDTCPLFCDFYNPHGGCEWHYQPCGAPCLKTCRNPSGHC 1189

Query: 759  ---LSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCL-HDGRYYPLGEVFYPGPECE 814
               L   EGC   C       +    + D    V QCGC   DG YY +G        C+
Sbjct: 1190 LVDLPGLEGCYPKCP-----PSQPFFNEDQMKCVAQCGCYDKDGNYYDVGARVPTAENCQ 1244

Query: 815  RRCECGPGGHVTCQEGAACGPHEECR----------LEDGVQACHATGCGRCLANGGI 862
              C C P G        AC    E R            DG+ AC    CG   +NG I
Sbjct: 1245 -SCNCTPSGIQCAHSLEACTCTYEDRTYSYQDVIYNTTDGLGACLIAICG---SNGTI 1298



 Score =  126 bits (317), Expect = 1e-28
 Identities = 127/461 (27%), Positives = 177/461 (38%), Gaps = 40/461 (8%)

Query: 41   LLSPDPCHGVTCRPQET-CKEQGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTC 97
            LL P P   VTC  +    K       C  +YE  C   +WG  HY +FDG  + F+G C
Sbjct: 5041 LLDPKPVANVTCVNKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTSYTFRGNC 5100

Query: 98   NYVL-----ATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
             YVL     A  G L +           T    R   A+S +   ++  + T   +H  E
Sbjct: 5101 TYVLMREIHARFGNLSLYLDNHYCTASATAAAARCPRALS-IHYKSMDIVLTVTMVHGKE 5159

Query: 153  IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRV-DVTLP-SSYH 210
             G +  + +  +   S     +SV    +  + +   G+ V++  N +V    LP S +H
Sbjct: 5160 EGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTF--NGQVFQARLPYSLFH 5217

Query: 211  GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTC-PE 268
                G CG    N  +D +  +GT A S      +W  P      CW    G+ PT  P 
Sbjct: 5218 NNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVPDSRKDGCWAP-TGTPPTASPA 5276

Query: 269  DRLEQYEGPGFCGP---LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKAL 325
              +     P  C P           F  CH  VPP  FF  C+ D C   G  ++ C++L
Sbjct: 5277 APVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDHCR--GRLEVPCQSL 5334

Query: 326  ASYVAACQAAGVVIEDWRAQVG--CEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG 383
             +Y   C+A G V  DWR   G  C++TCP    Y+ CGP  PA+C S          EG
Sbjct: 5335 EAYAELCRARG-VCSDWRGATGGLCDLTCPPTKVYKPCGPIQPATCNS---RNQSPQLEG 5390

Query: 384  PCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSL 443
               EGC C    +L           C C     + +   E W      Q C C  G  S+
Sbjct: 5391 -MAEGCFCPEDQILFNAHMGICVQACPCVGPDGFPKFPGERWVSN--CQSCVCDEGSVSV 5447

Query: 444  VCTPASCGL----------GEVCGLLPSGQHGCQPVSTAEC 474
             C P  C            G V    P  ++ C P +   C
Sbjct: 5448 QCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVC 5488



 Score =  112 bits (280), Expect = 2e-24
 Identities = 136/554 (24%), Positives = 194/554 (35%), Gaps = 98/554 (17%)

Query: 739  CPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCG----- 793
            C  H   +    +CP S P +S+      +   GC          D  +P+ Q       
Sbjct: 4976 CNQHCDIDRFQGACPTSPPPVSSAPLSSPSPAPGC----------DNAIPLRQVNETWTL 5025

Query: 794  -------CLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQ 846
                   C+ D R   L              +  P  +VTC        H   ++ D  Q
Sbjct: 5026 ENCTVARCVGDNRVVLL--------------DPKPVANVTC-----VNKHLPIKVSDPSQ 5066

Query: 847  ACHATGCGRCLAN--GGIHYITLDGRVYDLHGSCSYVLAQVCHPKPG------DEDFSIV 898
             C       C+ +  GG HY T DG  Y   G+C+YVL +  H + G      D  +   
Sbjct: 5067 PCDFHYECECICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTA 5126

Query: 899  LEKNAAGDLQRLLVTVAGQV-----VSLAQGQQ---VTVDGEAVALPVAVGRVRVTAEGR 950
                AA    R L      +     V++  G++   +  D   V+   +   V V+  G 
Sbjct: 5127 SATAAAARCPRALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGT 5186

Query: 951  NMVLQTTK--GLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSV 1008
              +       G+ + F+G         S F     G CG    N  DD +  +G+ A+S 
Sbjct: 5187 TTMRVDIPALGVSVTFNGQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASC 5246

Query: 1009 ETFGAAWRVPGSSK-GCGEGCG-----PQGCPVCLAEETAPYESNEACGQLRNPQGPFAT 1062
            +     W VP S K GC    G         PV       P      C  + +    FA 
Sbjct: 5247 KDMAKTWLVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQ--VFAE 5304

Query: 1063 CQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWR--TDSFCPLH 1120
            C  ++ P  +F  C+ D C  +G     C+SL AY   C+A GV    WR  T   C L 
Sbjct: 5305 CHNLVPPGPFFNACISDHC--RGRLEVPCQSLEAYAELCRARGVC-SDWRGATGGLCDLT 5361

Query: 1121 CPAHSHYSICTRTCQGSCAA------LSGLTGCTTRCFEGCEC-DDRFLLSQGVCIPVQD 1173
            CP    Y  C      +C +      L G+        EGC C +D+ L +  + I VQ 
Sbjct: 5362 CPPTKVYKPCGPIQPATCNSRNQSPQLEGMA-------EGCFCPEDQILFNAHMGICVQA 5414

Query: 1174 CGCTHNGRYLPVNSSLLTSDCSERCSCSSSS------GLTCQAAGCP-----PGRVCEVK 1222
            C C     +         S+C + C C   S       L C A G P     PG V   +
Sbjct: 5415 CPCVGPDGFPKFPGERWVSNC-QSCVCDEGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTR 5473

Query: 1223 AEARNCWATRGLCV 1236
              A N      +CV
Sbjct: 5474 PRAENPCCPETVCV 5487



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 127/558 (22%), Positives = 203/558 (36%), Gaps = 109/558 (19%)

Query: 322  CKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV--CGPPCPASCP--SPAPLTT 377
            C+A   + +     G VI +   + GC      N H ++      CP S P  S APL++
Sbjct: 4948 CRAFGQFFSP----GEVIYNKTDRAGCHFYAVCNQHCDIDRFQGACPTSPPPVSSAPLSS 5003

Query: 378  PAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCG 437
            P+   G                D  +PL                +E W    C+   RC 
Sbjct: 5004 PSPAPG---------------CDNAIPLRQV-------------NETWTLENCTV-ARCV 5034

Query: 438  PGGGSLVCTP-----ASCGLGEVCGLLPSGQHGCQPVSTAEC--QAWGDPHYVTLDGHRF 490
                 ++  P      +C    +   +      C      EC    WG  HY T DG  +
Sbjct: 5035 GDNRVVLLDPKPVANVTCVNKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTSY 5094

Query: 491  DFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYT----RSVTLQIYNHSLTLS 546
             F+G C Y+L    H       N ++ + N +  + A +      R++++   +  + L+
Sbjct: 5095 TFRGNCTYVLMREIHA---RFGNLSLYLDNHYCTASATAAAARCPRALSIHYKSMDIVLT 5151

Query: 547  -----ARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTS-GLSLAFDGDSFVRLR 600
                  +    +  D + V+  F  + +L + L    + V   + G+S+ F+G  F + R
Sbjct: 5152 VTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFNGQVF-QAR 5210

Query: 601  VP-AAYAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGAQ--GC------- 642
            +P + +  +  G CG    +  DD     G  A         W V  ++  GC       
Sbjct: 5211 LPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVPDSRKDGCWAPTGTP 5270

Query: 643  ------GECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLL 696
                      S P P+PC P+          C ++ +     A CH LVPP  +F  C+ 
Sbjct: 5271 PTASPAAPVSSTPTPTPCPPQ--------PLCDLMLSQ--VFAECHNLVPPGPFFNACIS 5320

Query: 697  DACQVQGHPGGLCPAVATYVAACQAAGAQLGEWR--RPDFCPLQCPAHSHYELCGDSCPV 754
            D C  +G     C ++  Y   C+A G    +WR      C L CP    Y+ CG   P 
Sbjct: 5321 DHC--RGRLEVPCQSLEAYAELCRARGV-CSDWRGATGGLCDLTCPPTKVYKPCGPIQPA 5377

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVL-SGDTCVPVGQCGCLHDGRYYPLGEVFYPGPEC 813
            +C S +     E    EGC C    +L +    + V  C C+      P G   +PG   
Sbjct: 5378 TCNSRNQSPQLEGMA-EGCFCPEDQILFNAHMGICVQACPCVG-----PDGFPKFPGERW 5431

Query: 814  ERRCECGPGGHVTCQEGA 831
               C+        C EG+
Sbjct: 5432 VSNCQ-----SCVCDEGS 5444



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 53/213 (24%), Positives = 72/213 (33%), Gaps = 53/213 (24%)

Query: 602  PAAYAASLCGLCGNYNQDPA----DDLKAVGGKPAGWQVGGAQG--CGECVSKPCPSP-- 653
            P A    +C       QDP     +D       P G++     G  CGECV   C +P  
Sbjct: 5540 PGALPCHMCTCLSGDTQDPTVQCQEDACNNTTCPQGFEYKRVAGQCCGECVQTACLTPDG 5599

Query: 654  ----------------CTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLD 697
                            CT    E+ GG        A+   ++ C G +        C  D
Sbjct: 5600 QPVQLNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCCYSCEED 5659

Query: 698  ACQVQ------GHPG-----------GLCPAVATYVAACQAAGAQLG--EWRR--PDFCP 736
            +CQV+       H G           G CP  + Y A  QA   Q    + RR   +  P
Sbjct: 5660 SCQVRINTTILWHQGCETEVNITFCEGSCPGASKYSAEAQAMQHQCTCCQERRVHEETVP 5719

Query: 737  LQCP-------AHSHYELCGDSCPVSCPSLSAP 762
            L CP        ++H + CG   P   P+  AP
Sbjct: 5720 LHCPNGSAILHTYTHVDECG-CTPFCVPAPMAP 5751


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score =  346 bits (888), Expect = 8e-95
 Identities = 340/1345 (25%), Positives = 487/1345 (36%), Gaps = 242/1345 (17%)

Query: 75   CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
            C  WGD HY +FDG  F F G CNYV +              F V  +    G+  V  V
Sbjct: 733  CSTWGDFHYKTFDGDVFRFPGLCNYVFSEH-----CRAAYEDFNVQLRRGLVGSRPV--V 785

Query: 135  RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVS 194
              V + A G  +       G V +NG    LP S    R  +    S   +     L ++
Sbjct: 786  TRVVIKAQGLVLEASN---GSVLINGQREELPYS----RTGLLVEQSGDYIKVSIRLVLT 838

Query: 195  YDWNWRVD--VTLPSSYHGAVCGLCGNMDRNPNNDQVFP-NGTLAPSIPIWGGSWRAPGW 251
            + WN      + L   Y    CGLCG+ +  P  ++ +  N  L P    +G   +  G 
Sbjct: 839  FLWNGEDSALLELDPKYANQTCGLCGDFNGLPAFNEFYAHNARLTPLQ--FGNLQKLDGP 896

Query: 252  DPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV 311
               C D        C ++        G C     G    F  CHA V   ++   C  D+
Sbjct: 897  TEQCPDPLPLPAGNCTDEE-------GICHRTLLGPA--FAECHALVDSTAYLAACAQDL 947

Query: 312  CMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPS 371
            C         C     Y   C  AG    +WR    C  TCP N  ++ CG PC  +C +
Sbjct: 948  CRCP---TCPCATFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSN 1004

Query: 372  PAPLTTPAVCEGPCVEGCQCDAGFV------LSADRCVPLNNGCGCWANGTYHEAGSEFW 425
            P       +CE  CV+GC C  G        ++   C+PL   C C   G  +  G+ F 
Sbjct: 1005 P---QRAQLCEDHCVDGCFCPPGRSCTVLDDITHSGCLPLGQ-CPCTHGGRTYSPGTSF- 1059

Query: 426  ADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTL 485
             + TCS  C C   GG   C    C                       C   G  H  T 
Sbjct: 1060 -NTTCSS-CTC--SGGLWQCQDLPC--------------------PGTCSVQGGAHISTY 1095

Query: 486  DGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTLQIYNHSLT 544
            D   +D  G C Y+LS  C        +FTV       G +   +  ++VTL +      
Sbjct: 1096 DEKLYDLHGDCSYVLSKKC-----ADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTA 1150

Query: 545  LSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVR--LRVP 602
            +  +    + ++ ++  LP    ++     S   +VV T  GL L       ++  +R+ 
Sbjct: 1151 IRVQADGGVFLNSIYTQLPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLD 1210

Query: 603  AAYAASLCGLCGNYNQDPADDLKAVGG-----KPAGWQVGGAQGCGECVSKPCPSPCTPE 657
             A+   +CGLCGN+NQ+ ADD  A+ G       A      AQ            PC+  
Sbjct: 1211 PAHQGQMCGLCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLS 1270

Query: 658  QQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVA 717
             +        C  ++  +   + CH ++ P  +   C+ D C  +     LC A+++YV 
Sbjct: 1271 VENENYARHWCSRLTDPNSAFSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVH 1330

Query: 718  ACQAAGAQLGEWRRPDFCP---LQCPAHSHYELCGDSCPVSCPSLSAPEGCESAC---RE 771
            AC A G QL +W R   C      CP    Y    D+C  +C  LS  +   S      +
Sbjct: 1331 ACAAKGVQLSDW-RDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADVTCSVSFVPVD 1389

Query: 772  GCVCDAG-FVLSGDTCVPVGQCGCLHDGRYYPLGEVFY---------------------- 808
            GC C AG F+     CVP  +C C   G     GEV +                      
Sbjct: 1390 GCTCPAGTFLNDAGACVPAQECPCYAHGTVLAPGEVVHDEGAVCSCTGGKLSCLGASLQK 1449

Query: 809  --------------------PGPECERRCE----------------CGPG------GHVT 826
                                PG EC R C                 C PG      G   
Sbjct: 1450 STGCAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI 1509

Query: 827  CQEGAAC-------GPHEECRLEDGVQAC--------HATGCGRCLANGGIHYITLDGRV 871
             +E   C        P E  R++     C        H    G C+A G  H+IT DG  
Sbjct: 1510 AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDR 1569

Query: 872  YDLHGSCSYVLAQ-VCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVD 930
            Y   GSC Y+LAQ  C        F IV E    G             V +     V+  
Sbjct: 1570 YSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTP 1629

Query: 931  GEAVALP----------------------VAVGRVRVTAEGRN------------MVLQT 956
              A   P                      +  G  +  A G               ++  
Sbjct: 1630 DPAANEPAPREASVGFRQRLPPLQSYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIE 1689

Query: 957  TKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWR 1016
            T G+ + +D    + + +   ++GR+CGLCGNF+ N  +DF   + S       FG +W+
Sbjct: 1690 THGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGDALEFGNSWK 1749

Query: 1017 VPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQC 1076
            +   S  C +   P+    C A       + + C  L  P   FA C++ +  ++Y+  C
Sbjct: 1750 L---SPSCPDALAPK--DPCTANPFRKSWAQKQCSILHGP--TFAACRSQVDSTKYYEAC 1802

Query: 1077 VYDLCA--QKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHS-------HY 1127
            V D CA    GD    C ++AAY  AC  AG+ V  WRT   CPL C  ++       HY
Sbjct: 1803 VNDACACDSGGDCECFCTAVAAYAQACHDAGLCVS-WRTPDTCPLFCDFYNPHGGCEWHY 1861

Query: 1128 SICTRTCQGSC--------AALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGC-TH 1178
              C   C  +C          L GL GC  +C         F   Q  C  V  CGC   
Sbjct: 1862 QPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKC---PPSQPFFNEDQMKC--VAQCGCYDK 1916

Query: 1179 NGRYLPVNSSLLTSDCSERCSCSSSSGLTC----QAAGCP-PGRVCEVKAEARNCWATRG 1233
            +G Y  V + + T++  + C+C + SG+ C    +A  C    R    +    N     G
Sbjct: 1917 DGNYYDVGARVPTAENCQSCNC-TPSGIQCAHSLEACTCTYEDRTYSYQDVIYNTTDGLG 1975

Query: 1234 LCVLSV-GANLTTFDGARGATTSPG 1257
             C++++ G+N T     R A   PG
Sbjct: 1976 ACLIAICGSNGTII---RKAVACPG 1997



 Score =  226 bits (577), Expect = 9e-59
 Identities = 253/976 (25%), Positives = 361/976 (36%), Gaps = 197/976 (20%)

Query: 43   SPDPCHGVTCRPQETCKEQGGQGVC--LPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYV 100
            SP      TC    +C   GG   C  LP    TC + G  H  ++D + +D  G C+YV
Sbjct: 1054 SPGTSFNTTC---SSCTCSGGLWQCQDLP-CPGTCSVQGGAHISTYDEKLYDLHGDCSYV 1109

Query: 101  LATTGCLGVSTQGLTPFTVT--TKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRV 158
            L+   C   S   L        T NEN        ++ VT++  G + +I     G V +
Sbjct: 1110 LSKK-CADSSFTVLAELRKCGLTDNEN-------CLKAVTLSLDGGDTAIRVQADGGVFL 1161

Query: 159  NGVLTALPVSVADGRISVAQGASKALLV-ADFGLQVSYDWN--WRVDVTLPSSYHGAVCG 215
            N + T LP+S A+  I++   +S  ++V    GLQ+        +V V L  ++ G +CG
Sbjct: 1162 NSIYTQLPLSAAN--ITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCG 1219

Query: 216  LCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYE 275
            LCGN ++N  +D    +G +  +   +  +W+A        +     C    E+  E Y 
Sbjct: 1220 LCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLSVEN--ENY- 1276

Query: 276  GPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335
               +C  L       F+ CH+ + P+ F   C+ D C      D LC AL+SYV AC A 
Sbjct: 1277 ARHWCSRLTDPNSA-FSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVHACAAK 1335

Query: 336  GVVIEDWRAQVGCEI--TCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDA 393
            GV + DWR  V  +    CP++  Y      C  +C   +            V+GC C A
Sbjct: 1336 GVQLSDWRDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADVTCSVSFVPVDGCTCPA 1395

Query: 394  G-FVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPAS--- 449
            G F+  A  CVP    C C+A+GT    G     +G       C   GG L C  AS   
Sbjct: 1396 GTFLNDAGACVPAQE-CPCYAHGTVLAPGEVVHDEGAV-----CSCTGGKLSCLGASLQK 1449

Query: 450  ----------------------------------------CGLGEVC--GLLPSGQHGCQ 467
                                                    C  G VC  GL+  G  GC 
Sbjct: 1450 STGCAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI 1509

Query: 468  PVSTAEC------------------------QAWGDPHYVTL--------------DGHR 489
                  C                        + W   H + L              DG R
Sbjct: 1510 AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDR 1569

Query: 490  FDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTL--------QIYNH 541
            + F+G+CEY+L+    G       F +   N   G+   + ++++ L         +   
Sbjct: 1570 YSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTP 1629

Query: 542  SLTLSARWPRKLQVDGVFVALPFQLDSLL--------HAHLSGAD----------VVVTT 583
                +   PR+  V       P Q   L+         A   G D           +V  
Sbjct: 1630 DPAANEPAPREASVGFRQRLPPLQSYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIE 1689

Query: 584  TSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCG 643
            T G+++++D  + V +R+   Y   +CGLCGN++ +  +D            VG A   G
Sbjct: 1690 THGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRS----VVGDALEFG 1745

Query: 644  EC--VSKPCP------SPCTPEQQESFGGPDACGVISATDGP-LAPCHGLVPPAQYFQGC 694
                +S  CP       PCT            C ++    GP  A C   V   +Y++ C
Sbjct: 1746 NSWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSIL---HGPTFAACRSQVDSTKYYEAC 1802

Query: 695  LLDACQVQ--GHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHS-------HY 745
            + DAC     G     C AVA Y  AC  AG  +  WR PD CPL C  ++       HY
Sbjct: 1803 VNDACACDSGGDCECFCTAVAAYAQACHDAGLCV-SWRTPDTCPLFCDFYNPHGGCEWHY 1861

Query: 746  ELCGDSCPVSC--PS------LSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCL-H 796
            + CG  C  +C  PS      L   EGC   C       +    + D    V QCGC   
Sbjct: 1862 QPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKCP-----PSQPFFNEDQMKCVAQCGCYDK 1916

Query: 797  DGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECR----------LEDGVQ 846
            DG YY +G        C+  C C P G        AC    E R            DG+ 
Sbjct: 1917 DGNYYDVGARVPTAENCQ-SCNCTPSGIQCAHSLEACTCTYEDRTYSYQDVIYNTTDGLG 1975

Query: 847  ACHATGCGRCLANGGI 862
            AC    CG   +NG I
Sbjct: 1976 ACLIAICG---SNGTI 1988



 Score =  202 bits (513), Expect = 2e-51
 Identities = 170/597 (28%), Positives = 241/597 (40%), Gaps = 79/597 (13%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-----SQAV 528
            C  WG  HY T DG  F F G C Y+ S  C       E+F + +           S+ +
Sbjct: 81   CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGA---AYEDFNIQLRRSQESAAPTLSRVL 137

Query: 529  SYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLS 588
                 V +Q+   S+           V+G  V LPF    +L    S +   V    GL 
Sbjct: 138  MKVDGVVIQLTKGSVL----------VNGHPVLLPFSQSGVL-IQQSSSYTKVEARLGLV 186

Query: 589  LAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPA-DDLKAVGGKPAGWQVGGAQGCGECVS 647
            L ++ D  + L +   YA   CGLCG++N  P   +L +   K    + G  Q   +  +
Sbjct: 187  LMWNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPMEFGNLQKMDD-PT 245

Query: 648  KPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGCLLDACQVQGHP- 705
            + C  P     +    G   C  +    G L + C  LV    Y + C  D C  +    
Sbjct: 246  EQCQDPVPEPPRNCSTGFGICEEL--LHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDL 303

Query: 706  -GGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
               +C  +A Y   C  AG    +WR PDFCP +CP +  Y  C   C  +C +      
Sbjct: 304  LSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCADTCSNQEHSRA 363

Query: 765  CESACREGCVCDAGFVLS--GDT-CVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGP 821
            CE  C  GC C  G VL   G T CVPV +C C+++G  Y  G  +    +C   C C  
Sbjct: 364  CEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAPGATY--STDC-TNCTCS- 419

Query: 822  GGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYV 881
            GG  +CQE   C                    G C   GG H+ T DG+ Y +HG CSYV
Sbjct: 420  GGRWSCQE-VPCP-------------------GTCSVLGGAHFSTFDGKQYTVHGDCSYV 459

Query: 882  LAQVCHPKPGDEDFSIVLEKNAAG--DLQRLLVTV------AGQVVSLAQGQQVTVDGEA 933
            L + C        F+++ E    G  D +  L +V      A  VV +    +V ++   
Sbjct: 460  LTKPC----DSSAFTVLAELRRCGLTDSETCLKSVTLSLDGAQTVVVIKASGEVFLNQIY 515

Query: 934  VALPVAVGRVRVTAEGRNMVL-QTTKGLRLLFD--GDAHLLMSIPSPFRGRLCGLCGNFN 990
              LP++   V +       ++ QT+ GL+L         L M +    RG+ CGLCGNFN
Sbjct: 516  TQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFN 575

Query: 991  GNWSDDFVLPNG----SAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAP 1043
               +DDF   +G    +AA+   TF      P       + C        L+ E AP
Sbjct: 576  SIQADDFRTLSGVVEATAAAFFNTFKTQAACPNIRNSFEDPCS-------LSVENAP 625



 Score =  185 bits (469), Expect = 3e-46
 Identities = 153/557 (27%), Positives = 248/557 (44%), Gaps = 61/557 (10%)

Query: 845  VQACHATGCGR-CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVL---E 900
            V+A +    GR C   G  HY T DG V+   G C+YV ++ C      EDF+I L   +
Sbjct: 69   VRASNPAHNGRVCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGA--AYEDFNIQLRRSQ 126

Query: 901  KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGL 960
            ++AA  L R+L+ V G V+ L +G  V V+G  V LP +   V +        ++   GL
Sbjct: 127  ESAAPTLSRVLMKVDGVVIQLTKGS-VLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGL 185

Query: 961  RLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGS 1020
             L+++ D  LL+ + + +  + CGLCG+FNG      +L + +  + +E FG   ++   
Sbjct: 186  VLMWNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDP 244

Query: 1021 SKGCGEGC--GPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVY 1078
            ++ C +     P+ C                C +L + Q  F+ C A++    Y   C  
Sbjct: 245  TEQCQDPVPEPPRNCSTGFG----------ICEELLHGQ-LFSGCVALVDVGSYLEACRQ 293

Query: 1079 DLCAQKGDK--AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQG 1136
            DLC  +     + +C +LA Y+  C  AG   + WR   FCP  CP +  Y  C   C  
Sbjct: 294  DLCFCEDTDLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCAD 353

Query: 1137 SCAALSGLTGCTTRCFEGCECDDRFLL---SQGVCIPVQDCGCTHNG-RYLPVNSSLLTS 1192
            +C+       C   C  GC C +  +L    Q  C+PV  C C +NG  Y P   +  ++
Sbjct: 354  TCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAP--GATYST 411

Query: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252
            DC+  C+CS     +CQ   CP                  G C +  GA+ +TFDG +  
Sbjct: 412  DCT-NCTCSGGR-WSCQEVPCP------------------GTCSVLGGAHFSTFDGKQYT 451

Query: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICH-GKTEAVGQVHIFFQDGMVTLTPNKG- 1310
                  Y L+  C         + V+AE++ C    +E   +      DG  T+   K  
Sbjct: 452  VHGDCSYVLTKPCDSSA-----FTVLAELRRCGLTDSETCLKSVTLSLDGAQTVVVIKAS 506

Query: 1311 --VWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQ--VWLGANGKVAVIVSNDHAG 1366
              V++N +   LP    A+V++ R     ++ +   G+Q  + L    ++ + ++    G
Sbjct: 507  GEVFLNQIYTQLPI-SAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRG 565

Query: 1367 KLCGACGNFDGDQTNDW 1383
            + CG CGNF+  Q +D+
Sbjct: 566  QTCGLCGNFNSIQADDF 582



 Score =  172 bits (436), Expect = 2e-42
 Identities = 170/647 (26%), Positives = 257/647 (39%), Gaps = 80/647 (12%)

Query: 75  CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
           C  WG  HY +FDG  F F G CNYV +     G + +         +++    P +S V
Sbjct: 81  CSTWGSFHYKTFDGDVFRFPGLCNYVFSEH--CGAAYEDFN--IQLRRSQESAAPTLSRV 136

Query: 135 RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVS 194
               +   G  I + K   G V VNG    LP S +   + + Q +S   + A  GL + 
Sbjct: 137 ---LMKVDGVVIQLTK---GSVLVNGHPVLLPFSQSG--VLIQQSSSYTKVEARLGLVLM 188

Query: 195 YDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPL 254
           ++ +  + + L + Y    CGLCG+ +  P   ++  + T     P+  G+ +    DP 
Sbjct: 189 WNHDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLT--PMEFGNLQKMD-DPT 245

Query: 255 CWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMG 314
             ++C+   P  P +      G G C  L  G    F+ C A V   S+ + C  D+C  
Sbjct: 246 --EQCQDPVPEPPRNCST---GFGICEELLHGQ--LFSGCVALVDVGSYLEACRQDLCFC 298

Query: 315 GGDHDIL---CKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPS 371
             D D+L   C  LA Y   C  AG + +DWR    C   CP N  Y  C  PC  +C +
Sbjct: 299 E-DTDLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCADTCSN 357

Query: 372 PAPLTTPAVCEGPCVEGCQCDAGFVL---SADRCVPLNNGCGCWANGTYHEAGSEFWADG 428
                    CE  CV GC C  G VL       CVP++  C C  NG  +  G+ +  D 
Sbjct: 358 Q---EHSRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSK-CACVYNGAAYAPGATYSTD- 412

Query: 429 TCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPV-STAECQAWGDPHYVTLDG 487
                           CT  +C           G+  CQ V     C   G  H+ T DG
Sbjct: 413 ----------------CTNCTCS---------GGRWSCQEVPCPGTCSVLGGAHFSTFDG 447

Query: 488 HRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTLQIYNHSLTLS 546
            ++   G C Y+L+ PC      +  FTV       G + + +  +SVTL +      + 
Sbjct: 448 KQYTVHGDCSYVLTKPC-----DSSAFTVLAELRRCGLTDSETCLKSVTLSLDGAQTVVV 502

Query: 547 ARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAA-- 604
            +   ++ ++ ++  LP    ++     S   ++  T+ GL L       ++L +  A  
Sbjct: 503 IKASGEVFLNQIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPK 562

Query: 605 YAASLCGLCGNYNQDPADDLKAVGG-----KPAGWQVGGAQGCGECVSKPCPSPC--TPE 657
                CGLCGN+N   ADD + + G       A +     Q     +      PC  + E
Sbjct: 563 LRGQTCGLCGNFNSIQADDFRTLSGVVEATAAAFFNTFKTQAACPNIRNSFEDPCSLSVE 622

Query: 658 QQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
                G P AC  +      LA    LV P    QG +  + +  GH
Sbjct: 623 NAPRMGAPSACRTL-----VLALAAMLVVPQAETQGPVEPSWENAGH 664



 Score =  171 bits (432), Expect = 6e-42
 Identities = 143/549 (26%), Positives = 238/549 (43%), Gaps = 70/549 (12%)

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD---LQRLLV 912
            C   G  HY T DG V+   G C+YV ++ C  +   EDF++ L +   G    + R+++
Sbjct: 733  CSTWGDFHYKTFDGDVFRFPGLCNYVFSEHC--RAAYEDFNVQLRRGLVGSRPVVTRVVI 790

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM 972
               G V+  + G  V ++G+   LP +   + V   G  + +     L  L++G+   L+
Sbjct: 791  KAQGLVLEASNGS-VLINGQREELPYSRTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALL 849

Query: 973  SIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQG 1032
             +   +  + CGLCG+FNG  + +    + +  + ++ FG   ++ G ++ C +   P  
Sbjct: 850  ELDPKYANQTCGLCGDFNGLPAFNEFYAHNARLTPLQ-FGNLQKLDGPTEQCPDPL-PLP 907

Query: 1033 CPVCLAEETAPYESNEACGQLRNPQGP-FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLC 1091
               C  EE   +         R   GP FA C A++  + Y   C  DLC         C
Sbjct: 908  AGNCTDEEGICH---------RTLLGPAFAECHALVDSTAYLAACAQDLCRCP---TCPC 955

Query: 1092 RSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRC 1151
             +   Y+  C  AG   + WR    CP  CP +  +  C   C  +C+       C   C
Sbjct: 956  ATFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSNPQRAQLCEDHC 1015

Query: 1152 FEGCEC---------DDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSS 1202
             +GC C         DD   ++   C+P+  C CTH GR     +S  T+ CS   SC+ 
Sbjct: 1016 VDGCFCPPGRSCTVLDD---ITHSGCLPLGQCPCTHGGRTYSPGTSFNTT-CS---SCTC 1068

Query: 1203 SSGL-TCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYEL 1261
            S GL  CQ   CP                  G C +  GA+++T+D           Y L
Sbjct: 1069 SGGLWQCQDLPCP------------------GTCSVQGGAHISTYDEKLYDLHGDCSYVL 1110

Query: 1262 SSRCPGLQNTIPWYRVVAEVQICHGKTE---AVGQVHIFFQDG--MVTLTPNKGVWVNGL 1316
            S +C     T     V+AE++ C G T+    +  V +    G   + +  + GV++N +
Sbjct: 1111 SKKCADSSFT-----VLAELRKC-GLTDNENCLKAVTLSLDGGDTAIRVQADGGVFLNSI 1164

Query: 1317 RVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSND--HAGKLCGACGN 1374
               LP    A++++       ++V+   G+Q+ +     + V V  D  H G++CG CGN
Sbjct: 1165 YTQLPLSA-ANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGN 1223

Query: 1375 FDGDQTNDW 1383
            F+ +Q +D+
Sbjct: 1224 FNQNQADDF 1232



 Score =  125 bits (314), Expect = 3e-28
 Identities = 123/461 (26%), Positives = 176/461 (38%), Gaps = 39/461 (8%)

Query: 39   LPLLSPDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCN 98
            LP+   DP        +  C+  GG+G+  P     C +WG  HY +FDG  + F+G C 
Sbjct: 5376 LPIKVSDPSQPCDFHYECECECVGGRGIT-PG-AGICSMWGGSHYSTFDGTSYTFRGNCT 5433

Query: 99   YVL-----ATTGCLGVSTQG-LTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDE 152
            YVL     A  G L +         + T        P    +   ++  + T   +H  E
Sbjct: 5434 YVLMREIHARFGNLSLYLDNHYCTASATAAAAAARCPRALSIHYKSMDIVLTVTMVHGKE 5493

Query: 153  IGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRV-DVTLP-SSYH 210
             G +  + +  +   S     +SV    +  + +   G+ V++  N +V    LP S +H
Sbjct: 5494 EGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTF--NGQVFQARLPYSLFH 5551

Query: 211  GAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAP-GWDPLCWDECRGSCPTC-PE 268
                G CG    N  +D +  +GT A S      +W  P      CW    G+ PT  P 
Sbjct: 5552 NNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVPDSRKDGCWAP-TGTPPTASPA 5610

Query: 269  DRLEQYEGPGFCGP---LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKAL 325
              +     P  C P           F  CH  VPP  FF  C+ D C   G  ++ C++L
Sbjct: 5611 APVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDHCR--GRLEVPCQSL 5668

Query: 326  ASYVAACQAAGVVIEDWRAQVG--CEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEG 383
             +Y   C+A G V  DWR   G  C++TCP    Y+ CGP  PA+C S          EG
Sbjct: 5669 EAYAELCRARG-VCSDWRGATGGLCDLTCPPTKVYKPCGPIQPATCNS---RNQSPQLEG 5724

Query: 384  PCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSL 443
               EGC C    +L           C C     + +   E W      Q C C  G  S+
Sbjct: 5725 -MAEGCFCPEDQILFNAHMGICVQACPCVGPDGFPKFPGERWVSN--CQSCVCDEGSVSV 5781

Query: 444  VCTPASCGL----------GEVCGLLPSGQHGCQPVSTAEC 474
             C P  C            G V    P  ++ C P +   C
Sbjct: 5782 QCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVC 5822



 Score =  116 bits (290), Expect = 2e-25
 Identities = 138/557 (24%), Positives = 187/557 (33%), Gaps = 89/557 (15%)

Query: 739  CPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCG----- 793
            C  H   +    +CP S P +S+      +   GC          D  +P+ Q       
Sbjct: 5295 CNQHCDIDRFQGACPTSPPPVSSAPLSSPSPAPGC----------DNAIPLRQVNETWTL 5344

Query: 794  -------CLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQ 846
                   C+ D R   L     P P     C               C  H EC  E    
Sbjct: 5345 ENCTVARCVGDNRVVLLD----PKPVANVTCVNKHLPIKVSDPSQPCDFHYECECECVGG 5400

Query: 847  ACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPG------DEDFSIVLE 900
                 G G C   GG HY T DG  Y   G+C+YVL +  H + G      D  +     
Sbjct: 5401 RGITPGAGICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASA 5460

Query: 901  KNAAG---------------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRV 945
              AA                D+   +  V G+   L    Q+ V        V V  +  
Sbjct: 5461 TAAAAAARCPRALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGT 5520

Query: 946  TAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAA 1005
            T    ++      G+ + F+G         S F     G CG    N  DD +  +G+ A
Sbjct: 5521 TTMRVDI---PALGVSVTFNGQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTA 5577

Query: 1006 SSVETFGAAWRVPGSSK-GCGEGCG-----PQGCPVCLAEETAPYESNEACGQLRNPQGP 1059
            +S +     W VP S K GC    G         PV       P      C  + +    
Sbjct: 5578 ASCKDMAKTWLVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQ--V 5635

Query: 1060 FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWR--TDSFC 1117
            FA C  ++ P  +F  C+ D C  +G     C+SL AY   C+A GV    WR  T   C
Sbjct: 5636 FAECHNLVPPGPFFNACISDHC--RGRLEVPCQSLEAYAELCRARGVC-SDWRGATGGLC 5692

Query: 1118 PLHCPAHSHYSICTRTCQGSCAA------LSGLTGCTTRCFEGCEC-DDRFLLSQGVCIP 1170
             L CP    Y  C      +C +      L G+        EGC C +D+ L +  + I 
Sbjct: 5693 DLTCPPTKVYKPCGPIQPATCNSRNQSPQLEGMA-------EGCFCPEDQILFNAHMGIC 5745

Query: 1171 VQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSS------GLTCQAAGCP-----PGRVC 1219
            VQ C C     +         S+C + C C   S       L C A G P     PG V 
Sbjct: 5746 VQACPCVGPDGFPKFPGERWVSNC-QSCVCDEGSVSVQCKPLPCDAQGQPPPCNRPGFVT 5804

Query: 1220 EVKAEARNCWATRGLCV 1236
              +  A N      +CV
Sbjct: 5805 VTRPRAENPCCPETVCV 5821



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 131/572 (22%), Positives = 201/572 (35%), Gaps = 122/572 (21%)

Query: 322  CKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEV--CGPPCPASCP--SPAPLTT 377
            C+A   + +     G VI +   + GC      N H ++      CP S P  S APL++
Sbjct: 5267 CRAFGQFFSP----GEVIYNKTDRAGCHFYAVCNQHCDIDRFQGACPTSPPPVSSAPLSS 5322

Query: 378  PAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCG 437
            P+   G                D  +PL                +E W    C+   RC 
Sbjct: 5323 PSPAPG---------------CDNAIPLRQV-------------NETWTLENCTV-ARCV 5353

Query: 438  PGGGSLVCTPAS---------------------CGLGEVCGLLPSGQHGCQPVSTAECQA 476
                 ++  P                       C     C     G  G  P     C  
Sbjct: 5354 GDNRVVLLDPKPVANVTCVNKHLPIKVSDPSQPCDFHYECECECVGGRGITP-GAGICSM 5412

Query: 477  WGDPHYVTLDGHRFDFQGTCEYLLSAPCHGP----PLGAENFTVTVANEHRGSQAVSYTR 532
            WG  HY T DG  + F+G C Y+L    H       L  +N   T A+    + A    R
Sbjct: 5413 WGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCT-ASATAAAAAARCPR 5471

Query: 533  SVTLQIYNHSLTLS-----ARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTS-G 586
            ++++   +  + L+      +    +  D + V+  F  + +L + L    + V   + G
Sbjct: 5472 ALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALG 5531

Query: 587  LSLAFDGDSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVG 637
            +S+ F+G  F + R+P + +  +  G CG    +  DD     G  A         W V 
Sbjct: 5532 VSVTFNGQVF-QARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVP 5590

Query: 638  GAQ--GC-------------GECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCH 682
             ++  GC                 S P P+PC P+          C ++ +     A CH
Sbjct: 5591 DSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQ--------PLCDLMLSQ--VFAECH 5640

Query: 683  GLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWR--RPDFCPLQCP 740
             LVPP  +F  C+ D C  +G     C ++  Y   C+A G    +WR      C L CP
Sbjct: 5641 NLVPPGPFFNACISDHC--RGRLEVPCQSLEAYAELCRARGV-CSDWRGATGGLCDLTCP 5697

Query: 741  AHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVL-SGDTCVPVGQCGCLHDGR 799
                Y+ CG   P +C S +     E    EGC C    +L +    + V  C C+    
Sbjct: 5698 PTKVYKPCGPIQPATCNSRNQSPQLEGMA-EGCFCPEDQILFNAHMGICVQACPCVG--- 5753

Query: 800  YYPLGEVFYPGPECERRCECGPGGHVTCQEGA 831
              P G   +PG      C+        C EG+
Sbjct: 5754 --PDGFPKFPGERWVSNCQ-----SCVCDEGS 5778



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 56/227 (24%), Positives = 97/227 (42%), Gaps = 30/227 (13%)

Query: 6   CGLACSNPQ------IPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCK 59
           C   C  P+      I  T  V +   A +YNG          +P   +   C     C 
Sbjct: 368 CVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAY-------APGATYSTDCT---NCT 417

Query: 60  EQGGQGVCLP-NYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118
             GG+  C       TC + G  H+ +FDG+++   G C+YVL T  C        + FT
Sbjct: 418 CSGGRWSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVL-TKPC------DSSAFT 470

Query: 119 VTTKNENRG-NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVA 177
           V  +    G   + + ++ VT++  G    +     G+V +N + T LP+S A+  +++ 
Sbjct: 471 VLAELRRCGLTDSETCLKSVTLSLDGAQTVVVIKASGEVFLNQIYTQLPISAAN--VTIF 528

Query: 178 QGASKALLV-ADFGLQVSYDW--NWRVDVTLPSSYHGAVCGLCGNMD 221
           + ++  ++     GLQ++       ++ + L     G  CGLCGN +
Sbjct: 529 RPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFN 575



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 70/281 (24%), Positives = 98/281 (34%), Gaps = 55/281 (19%)

Query: 1134 CQGSCAALSGLTGC-TTRCFEGCECDDRFLLS-QGVCIPVQDCGCTHN-GRYLPVNSSLL 1190
            C  SC  L    GC +T C  GC C    +    G CI  +DC C HN   Y P     +
Sbjct: 1474 CLRSCHTLD--VGCFSTHCVSGCVCPPGLVSDGSGGCIAEEDCPCVHNEATYKP--GETI 1529

Query: 1191 TSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGAR 1250
              DC+  C+C +     C    C                   G CV     +  TFDG R
Sbjct: 1530 RVDCN-TCTCRNRR-WECSHRLC------------------LGTCVAYGDGHFITFDGDR 1569

Query: 1251 GATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGK-TEAVGQVHIFFQDGMVTLTPNK 1309
             +      Y L+    G   T   +R+V E   C    T     + +F +          
Sbjct: 1570 YSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTP 1629

Query: 1310 GVWVN---------GLRVDLP--------AEKLASVSVSRTPDGS----------LLVRQ 1342
                N         G R  LP         ++    +V+R P G            LV +
Sbjct: 1630 DPAANEPAPREASVGFRQRLPPLQSYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIE 1689

Query: 1343 KAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
              G+ V       V + +  D+ G++CG CGNFD +  ND+
Sbjct: 1690 THGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDF 1730



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 50/202 (24%), Positives = 66/202 (32%), Gaps = 54/202 (26%)

Query: 602  PAAYAASLCGLCGNYNQDPA----DDLKAVGGKPAGWQVGGAQG--CGECVSKPCPSP-- 653
            P A    +C       QDP     +D       P G++     G  CGECV   C +P  
Sbjct: 5874 PGALPCHMCTCLSGDTQDPTVQCQEDACNNTTCPQGFEYKRVAGQCCGECVQTACLTPDG 5933

Query: 654  ----------------CTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLD 697
                            CT    E+ GG        A+   ++ C G +        C  D
Sbjct: 5934 QPVQLNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCCYSCEED 5993

Query: 698  ACQVQ------GHPG-----------GLCPAVATYVAACQAAGAQLG--EWRR--PDFCP 736
            +CQV+       H G           G CP  + Y A  QA   Q    + RR   +  P
Sbjct: 5994 SCQVRINTTILWHQGCETEVNITFCEGSCPGASKYSAEAQAMQHQCTCCQERRVHEETVP 6053

Query: 737  LQCP---------AHSHYELCG 749
            L CP          H+   LCG
Sbjct: 6054 LHCPNGSAILHTYTHAVQVLCG 6075


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score =  308 bits (790), Expect = 2e-83
 Identities = 277/1047 (26%), Positives = 390/1047 (37%), Gaps = 205/1047 (19%)

Query: 470  STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVS 529
            STA C  +G     T DG  + F G C YLL+  C        +F++ + +   G +   
Sbjct: 31   STARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQ-----KRSFSI-IGDFQNGKR--- 81

Query: 530  YTRSVTLQIYNHSLTLSARWPRKLQVDGVF------VALPFQLDSLLHAHLSGADVVVTT 583
                V+L +Y     L   +   L V+G        V++P+    L     +G   +   
Sbjct: 82   ----VSLSVY-----LGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGE 132

Query: 584  TSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQ 635
              G     DG    ++ +   Y    CGLCGN+N    DD     G            W 
Sbjct: 133  AYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWA 192

Query: 636  VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCL 695
            +   +   E  S P  S      +   G  + C ++ +T    A CH LV P  +   C 
Sbjct: 193  LSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTS-VFARCHPLVDPEPFVALCE 251

Query: 696  LDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVS 755
               C+  G     CPA+  Y   C   G  L  W     C   CPA   Y  C   C  +
Sbjct: 252  KTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCART 311

Query: 756  CPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECER 815
            C SL   E C+  C +GC C  G +L    CV   +C C+H G+ YP      PG    R
Sbjct: 312  CQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYP------PGTSLSR 365

Query: 816  RCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLH 875
             C         C+       +EEC              G CL  G  H+ + D R +   
Sbjct: 366  DCNT-----CICRNSQWICSNEECP-------------GECLVTGQSHFKSFDNRYFTFS 407

Query: 876  GSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVT---------VAGQVVSLAQGQQ 926
            G C Y+LA+ C     D  FSIV+E     D +  + T         +   +V L  G  
Sbjct: 408  GICQYLLARDCQ----DHSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAG 463

Query: 927  VTVDGEAVALPVAVGRVR----VTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRL 982
            V +DG+ V LP+  G +R    VTA  R   L   + L++ +DG   LL+ +   + G+ 
Sbjct: 464  VAMDGQDVQLPLLKGDLRIQHTVTASVR---LSYGEDLQMDWDGRGRLLVKLSPVYAGKT 520

Query: 983  CGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETA 1042
            CGLCGN+NGN  DDF+ P+G A   VE FG AW++ G  +   +    Q    C      
Sbjct: 521  CGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQK----QHSDPCALNPRM 576

Query: 1043 PYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQ 1102
               S EAC  L +P   F  C   +SP  Y R C YD+C+    +  LC +LA+Y AAC 
Sbjct: 577  TRFSEEACAVLTSPT--FEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACA 634

Query: 1103 AAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG-CTTRCFEGCECDDRF 1161
              GV V  WR    C L+CP    Y  C   C  +C +LS     C   C EGC C    
Sbjct: 635  GRGVRVA-WREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGL 693

Query: 1162 LLSQ-GVCIPVQDCGCTHN--------------------------------GRYLPVNSS 1188
             + + G C+P   C C ++                                G  LP   +
Sbjct: 694  YMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLP--DA 751

Query: 1189 LLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWAT---RGLCVLSVGANLTT 1245
            +L+S  S R   S S         CP   +   +AE   C  T     L  +S+G     
Sbjct: 752  VLSSPLSHRSKRSLSCRPPMVKLVCPADNL---RAEGLECTKTCQNYDLECMSMGC---- 804

Query: 1246 FDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEV------------------------ 1281
                 G    PG+    +RC  L+   P +    E                         
Sbjct: 805  ---VSGCLCPPGMVRHENRCVALERC-PCFHQGKEYAPGETVKIGCNTCVCRDRKWNCTD 860

Query: 1282 QICHGKTEAVGQVHIFFQDGMVTLTP------------------------NKG------- 1310
             +C      +G  H    DG+  L P                        NKG       
Sbjct: 861  HVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPSVK 920

Query: 1311 ------VWVNGLRVDL---------PAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGK 1355
                  + V G  ++L         P +      V  +    +L+  KA   VW   +  
Sbjct: 921  CKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSVVW-DRHLS 979

Query: 1356 VAVIVSNDHAGKLCGACGNFDGDQTND 1382
            ++V++   +  K+CG CGNFDG Q ND
Sbjct: 980  ISVVLKQTYQEKVCGLCGNFDGIQNND 1006



 Score =  276 bits (706), Expect = 1e-73
 Identities = 219/764 (28%), Positives = 302/764 (39%), Gaps = 76/764 (9%)

Query: 73  ATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVS 132
           A C L+G    ++FDG  + F G C+Y+LA  GC   S      F++    +N    ++S
Sbjct: 33  ARCSLFGSDFVNTFDGSMYSFAGYCSYLLAG-GCQKRS------FSIIGDFQNGKRVSLS 85

Query: 133 YVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQ 192
                    LG    IH    G V       ++P +     +    G  K L    +G  
Sbjct: 86  VY-------LGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYK-LSGEAYGFV 137

Query: 193 VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 252
              D +    V L   Y    CGLCGN +    +D +   GTL      +  SW     +
Sbjct: 138 ARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGE 197

Query: 253 PLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVC 312
             C +       +C     E  +G      L   T   F  CH  V PE F   C   +C
Sbjct: 198 QWC-ERASPPSSSCNISSGEMQKGLWEQCQLLKSTS-VFARCHPLVDPEPFVALCEKTLC 255

Query: 313 MGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSP 372
              G  +  C AL  Y   C   G+V+  W     C   CP    Y  C  PC  +C S 
Sbjct: 256 ECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQS- 314

Query: 373 APLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWAD-GTC- 430
             L    +C+  CV+GC C  G +L    CV  +  C C  +G  +  G+    D  TC 
Sbjct: 315 --LHINEMCQERCVDGCSCPEGQLLDEGLCVE-STECPCVHSGKRYPPGTSLSRDCNTCI 371

Query: 431 ---SQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDG 487
              SQW          +C+   C                      EC   G  H+ + D 
Sbjct: 372 CRNSQW----------ICSNEEC--------------------PGECLVTGQSHFKSFDN 401

Query: 488 HRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYN-HSLTLS 546
             F F G C+YLL+  C          TV  A++     AV  TRSVT+++   H+  + 
Sbjct: 402 RYFTFSGICQYLLARDCQDHSFSIVIETVQCADDR---DAVC-TRSVTVRLPGLHNSLVK 457

Query: 547 ARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYA 606
            +    + +DG  V LP     L   H   A V ++    L + +DG   + +++   YA
Sbjct: 458 LKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYA 517

Query: 607 ASLCGLCGNYNQDPADDLKAVGG--KPAGWQVGGAQGC-GEC--VSKPCPSPCTPEQQES 661
              CGLCGNYN +  DD     G  +P     G A    G+C  + K    PC    + +
Sbjct: 518 GKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMT 577

Query: 662 FGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQA 721
               +AC V+  T      CH  V P  Y + C  D C        LC A+A+Y AAC  
Sbjct: 578 RFSEEACAVL--TSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAG 635

Query: 722 AGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAP-EGCESACREGCVCDAGFV 780
            G ++  WR P  C L CP    Y  CG  C ++C SLS P E C  AC EGC C  G  
Sbjct: 636 RGVRVA-WREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLY 694

Query: 781 LS--GDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPG 822
           +   GD CVP  QC C +DG  +   ++F    +    C C  G
Sbjct: 695 MDERGD-CVPKAQCPCYYDGEIFQPEDIF---SDHHTMCYCEDG 734



 Score =  177 bits (449), Expect = 6e-44
 Identities = 144/542 (26%), Positives = 217/542 (40%), Gaps = 53/542 (9%)

Query: 855  RCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQR----L 910
            RC   G     T DG +Y   G CSY+LA  C  +     FSI+      GD Q      
Sbjct: 34   RCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKR----SFSII------GDFQNGKRVS 83

Query: 911  LVTVAGQV--VSLAQGQQVTVDGEAVALPVAV-GRVRVTAEGRNMVLQTTKGLRLLFDGD 967
            L    G+   + L     VT   + V++P A  G    T  G   +     G     DG 
Sbjct: 84   LSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGS 143

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEG 1027
             +  + +   +  + CGLCGNFN    DDF+   G+  S    F  +W +    + C   
Sbjct: 144  GNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERA 203

Query: 1028 CGPQG-CPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGD 1086
              P   C +   E        E C QL      FA C  ++ P  +   C   LC   G 
Sbjct: 204  SPPSSSCNISSGEMQKGLW--EQC-QLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGG 260

Query: 1087 KAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG 1146
                C +L  Y   C   G+ +  W   S C   CPA   Y  C   C  +C +L     
Sbjct: 261  LECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEM 320

Query: 1147 CTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGL 1206
            C  RC +GC C +  LL +G+C+   +C C H+G+  P  +S L+ DC+  C C +S  +
Sbjct: 321  CQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTS-LSRDCN-TCICRNSQWI 378

Query: 1207 TCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCP 1266
             C    CP                  G C+++  ++  +FD      +    Y L+  C 
Sbjct: 379  -CSNEECP------------------GECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQ 419

Query: 1267 GLQNTIPWYRVVAEVQICHGKTEAVGQVHIF-----FQDGMVTLTPNKGVWVNGLRVDLP 1321
                    + +V E   C    +AV    +        + +V L    GV ++G  V LP
Sbjct: 420  DHS-----FSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLP 474

Query: 1322 AEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTN 1381
              K   + +  T   S+ +     +Q+     G++ V +S  +AGK CG CGN++G+Q +
Sbjct: 475  LLK-GDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGD 533

Query: 1382 DW 1383
            D+
Sbjct: 534  DF 535



 Score =  154 bits (390), Expect = 4e-37
 Identities = 150/550 (27%), Positives = 211/550 (38%), Gaps = 73/550 (13%)

Query: 699  CQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPS 758
            C + G PG L P           +   L    RP    L CPA  +    G  C  +C +
Sbjct: 738  CTMSGVPGSLLPDAVLSSPLSHRSKRSLS--CRPPMVKLVCPA-DNLRAEGLECTKTCQN 794

Query: 759  LSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCE 818
                E     C  GC+C  G V   + CV + +C C H G+ Y  GE    G  C   C 
Sbjct: 795  YDL-ECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIG--CNT-CV 850

Query: 819  CGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSC 878
            C             C  H           C AT    C   G  HY+T DG  Y   G C
Sbjct: 851  CR-------DRKWNCTDH----------VCDAT----CSTIGMAHYLTFDGLKYLFPGEC 889

Query: 879  SYVLAQ-VCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTV-DGEA-VA 935
             YVL Q  C   PG   F I++            V    +V  L +G ++ + DGE  V 
Sbjct: 890  QYVLVQDYCGSNPGT--FRILVGNKGCSHPS---VKCKKRVTILVEGGEIELFDGEVNVK 944

Query: 936  LPVA-VGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWS 994
             P+       V   GR ++L   K L +++D    + + +   ++ ++CGLCGNF+G  +
Sbjct: 945  RPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQN 1004

Query: 995  DDFVLPNGSAASSVETFGAAWRVPGSSKGCGE------GCGPQGCPVCLAEETAPYESNE 1048
            +D    N         FG +W+V   S  C +         P  C   + ++T     + 
Sbjct: 1005 NDLTSSNLQVEEDPVDFGNSWKV---SSQCADTRKVPLDSSPATCHNNIMKQTM---VDS 1058

Query: 1049 ACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQK--GDKAFLCRSLAAYTAACQAAGV 1106
            +C  L +    F  C  ++ P  Y   C+YD C+ +  GD A  C ++AAY   C   G 
Sbjct: 1059 SCRILTS--DVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGK 1116

Query: 1107 AVKPWRTDSFCPLHCPAHS----------HYSICTRTCQGSCAALSGLTGCTTRCFEGC- 1155
             V  WRT + CP  C   +           Y+ C   CQ +C     L  C  +C EGC 
Sbjct: 1117 VV-TWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPL-ACPVQCVEGCH 1174

Query: 1156 -ECDDRFLLSQ--GVCIPVQDCG-CTHNGRYLPVNSSL-LTSDCSERCSCSSSS--GLTC 1208
              C    +L +    C+  +DC  C   GR       + L     E C         LTC
Sbjct: 1175 AHCPPGKILDELLQTCVDPEDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTC 1234

Query: 1209 QAAGCPPGRV 1218
            +A   P G V
Sbjct: 1235 EACQEPGGLV 1244



 Score =  134 bits (336), Expect = 8e-31
 Identities = 119/462 (25%), Positives = 184/462 (39%), Gaps = 60/462 (12%)

Query: 797  DGRYYPLGEVFYPGPECERRCECGPGGH-------VTCQEGA--ACGPHEECRLEDGVQA 847
            DG     G+V+    +C     C P G        V C  G   +C   +     +    
Sbjct: 1883 DGNEKRPGDVWTLPDQCHT-VTCQPDGQTLLKSHRVNCDRGLRPSCPNSQSPVKVEETCG 1941

Query: 848  CHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAA--- 904
            C  T    C  +   H +T DG+ + L GSCSYVL Q       ++D  ++L   A    
Sbjct: 1942 CRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQ-----NKEQDLEVILHNGACSPG 1996

Query: 905  ---GDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLR 961
               G ++ + V  +   V L    +VTV+G  V++P   G + V   G  M       L 
Sbjct: 1997 ARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLG 2056

Query: 962  LLF----DGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRV 1017
             +F      +   L   P  F  +  GLCG  + N ++DF+L +G+  +  +T    W V
Sbjct: 2057 HIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTV 2116

Query: 1018 PGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCV 1077
                +  G+ C P      + EE      +  C  L  P   FA C  VL+P+ ++  C 
Sbjct: 2117 ----QRPGQTCQP------ILEEQCLVPDSSHCQVLLLPL--FAECHKVLAPATFYAICQ 2164

Query: 1078 YDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGS 1137
             D C Q+     +C  +A+Y   C+  GV V  WRT  FC + CP    Y+ C   C   
Sbjct: 2165 QDSCHQEQ----VCEVIASYAHLCRTNGVCV-DWRTPDFCAMSCPPSLVYNHCEHGCPRH 2219

Query: 1138 CAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDC-------GCTHNGRYLPVNSSLL 1190
            C     ++ C     EGC C    ++ +G C+P + C       G  H      + + + 
Sbjct: 2220 CD--GNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQF----LEAWVP 2273

Query: 1191 TSDCSERCSCSSSSGLTCQAAGCPPGR-----VCEVKAEARN 1227
                 + C+C S   + C    CP  +     +CEV    +N
Sbjct: 2274 DHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQN 2315



 Score =  128 bits (321), Expect = 4e-29
 Identities = 115/416 (27%), Positives = 160/416 (38%), Gaps = 60/416 (14%)

Query: 47   CHGVTCRPQE-TCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            C+   CR ++  C +     VC    +ATC   G  HY +FDG K+ F G C YVL    
Sbjct: 846  CNTCVCRDRKWNCTDH----VC----DATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDY 897

Query: 106  CLGVSTQGLTP--FTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLT 163
            C      G  P  F +   N+   +P+V   + VT+   G  I +   E+   R      
Sbjct: 898  C------GSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKR------ 945

Query: 164  ALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRN 223
              P+   +    V +     +L+    L V +D +  + V L  +Y   VCGLCGN D  
Sbjct: 946  --PMK-DETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGI 1002

Query: 224  PNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECR----GSCPTCPEDRLEQYEGPGF 279
             NND    N  +      +G SW+       C D  +     S  TC  + ++Q      
Sbjct: 1003 QNNDLTSSNLQVEEDPVDFGNSWKV---SSQCADTRKVPLDSSPATCHNNIMKQTMVDSS 1059

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCM--GGGDHDILCKALASYVAACQAAGV 337
            C  L   T   F  C+  V PE +   C+ D C     GD    C  +A+Y   C   G 
Sbjct: 1060 CRIL---TSDVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGK 1116

Query: 338  VIEDWRAQVGCEITCPENS----------HYEVCGPPCPASCPSPAPLTTPAVCEGPCVE 387
            V+  WR    C  +C E +           Y  C P C  +C  P PL  P      CVE
Sbjct: 1117 VV-TWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACPV----QCVE 1171

Query: 388  GC--QCDAGFVLS--ADRCVPLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRC 436
            GC   C  G +L      CV   +   C   G    +G +     +D    Q C C
Sbjct: 1172 GCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHC 1227



 Score =  115 bits (288), Expect = 3e-25
 Identities = 124/500 (24%), Positives = 180/500 (36%), Gaps = 85/500 (17%)

Query: 361  CGPP-----CPASCPSPAPLTTPAVCEG--------PCVEGCQCDAGFVLSADRCVPLNN 407
            C PP     CPA       L     C+          CV GC C  G V   +RCV L  
Sbjct: 767  CRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALER 826

Query: 408  GCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQ 467
             C C     +H+ G E+    T    C       + VC        +         H C 
Sbjct: 827  -CPC-----FHQ-GKEYAPGETVKIGCN------TCVCRDRKWNCTD---------HVCD 864

Query: 468  PVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQA 527
                A C   G  HY+T DG ++ F G C+Y+L     G   G   F + V N+     +
Sbjct: 865  ----ATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPG--TFRILVGNKGCSHPS 918

Query: 528  VSYTRSVTLQIYNHSLTLSARWPRKLQVDG-VFVALPFQLDSLLHAHLSGADVVVTTTSG 586
            V   + VT+ +    + L          DG V V  P + ++      SG  +++     
Sbjct: 919  VKCKKRVTILVEGGEIEL---------FDGEVNVKRPMKDETHFEVVESGRYIILLLGKA 969

Query: 587  LSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKA----VGGKPA----GWQVGG 638
            LS+ +D    + + +   Y   +CGLCGN++    +DL +    V   P      W+V  
Sbjct: 970  LSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKV-- 1027

Query: 639  AQGCGECVSKP---CPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCL 695
            +  C +    P    P+ C     +      +C ++  T      C+ LV P  Y   C+
Sbjct: 1028 SSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRIL--TSDVFQDCNKLVDPEPYLDVCI 1085

Query: 696  LDACQVQ--GHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHS---------- 743
             D C  +  G     C  +A Y   C   G ++  WR    CP  C   +          
Sbjct: 1086 YDTCSCESIGDCACFCDTIAAYAHVCAQHG-KVVTWRTATLCPQSCEERNLRENGYECEW 1144

Query: 744  HYELCGDSCPVSCPSLSAPEGCESACREGC--VCDAGFVLSG--DTCVPVGQCG-CLHDG 798
             Y  C  +C V+C     P  C   C EGC   C  G +L     TCV    C  C   G
Sbjct: 1145 RYNSCAPACQVTCQH-PEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAG 1203

Query: 799  RYYPLGEVFYPGPECERRCE 818
            R +  G+     P     C+
Sbjct: 1204 RRFASGKKVTLNPSDPEHCQ 1223



 Score =  108 bits (271), Expect = 3e-23
 Identities = 101/405 (24%), Positives = 162/405 (40%), Gaps = 47/405 (11%)

Query: 465  GCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG 524
            GC+      C      H VT DG  F   G+C Y+L           E     + +    
Sbjct: 1941 GCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQ-------NKEQDLEVILHNGAC 1993

Query: 525  SQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTT 584
            S         ++++ + +L++      ++ V+G  V++P+ +   +  ++ GA +     
Sbjct: 1994 SPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPY-VGGNMEVNVYGAIMHEVRF 2052

Query: 585  SGLSLAF----DGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK-PAGWQVGGA 639
            + L   F      + F     P  +A+   GLCG  +++ A+D     G     W+    
Sbjct: 2053 NHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQ 2112

Query: 640  QGCGECVSKPCPSPCTPEQQESFGGPDA--CGVISATDGPL-APCHGLVPPAQYFQGCLL 696
            +     V +P  + C P  +E    PD+  C V+     PL A CH ++ PA ++  C  
Sbjct: 2113 EWT---VQRPGQT-CQPILEEQCLVPDSSHCQVLLL---PLFAECHKVLAPATFYAICQQ 2165

Query: 697  DACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSC 756
            D+C    H   +C  +A+Y   C+  G  + +WR PDFC + CP    Y  C   CP  C
Sbjct: 2166 DSC----HQEQVCEVIASYAHLCRTNGVCV-DWRTPDFCAMSCPPSLVYNHCEHGCPRHC 2220

Query: 757  PSLSAPEGCESAC----REGCVCDAGFVLSGDTCVPVGQC-GCL-HDGRYYPLGEVFYPG 810
                  +G  S+C     EGC C    V+   +CVP   C  C+  DG  +   E + P 
Sbjct: 2221 ------DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPD 2274

Query: 811  PECERRCECGPGGHVTC-------QEGAACGPHEECRLEDGVQAC 848
             +  + C C  G  V C        +   CG  E  RL      C
Sbjct: 2275 HQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQC 2319



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 115/469 (24%), Positives = 166/469 (35%), Gaps = 75/469 (15%)

Query: 44   PDPCHGVTCRP--QETCK------EQGGQGVCLPN------YEATCWL-WGDP------- 81
            PD CH VTC+P  Q   K      ++G +  C PN       E TC   W  P       
Sbjct: 1896 PDQCHTVTCQPDGQTLLKSHRVNCDRGLRPSC-PNSQSPVKVEETCGCRWTCPCVCTGSS 1954

Query: 82   --HYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTV 139
              H  +FDG+ F   G+C+YVL          Q L    +              ++ + V
Sbjct: 1955 TRHIVTFDGQNFKLTGSCSYVLFQN-----KEQDLE--VILHNGACSPGARQGCMKSIEV 2007

Query: 140  AALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSY-DWN 198
                 ++ +H D   +V VNG L ++P    +  ++V       +     G   ++   N
Sbjct: 2008 KHSALSVELHSDM--EVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQN 2065

Query: 199  WRVDVTL-PSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWD 257
                + L P ++     GLCG  D N  ND +  +GT+          W        C  
Sbjct: 2066 NEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQP 2125

Query: 258  ECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGD 317
                 C        +    P             F  CH  + P +F+  C  D C     
Sbjct: 2126 ILEEQCLVPDSSHCQVLLLP------------LFAECHKVLAPATFYAICQQDSC----H 2169

Query: 318  HDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTT 377
             + +C+ +ASY   C+  GV + DWR    C ++CP +  Y  C   CP  C        
Sbjct: 2170 QEQVCEVIASYAHLCRTNGVCV-DWRTPDFCAMSCPPSLVYNHCEHGCPRHCDG-----N 2223

Query: 378  PAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGC-WANGTYHEAGSEFWADGTCSQWCRC 436
             + C     EGC C    V+    CVP      C   +G  H+    +  D    Q C C
Sbjct: 2224 VSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTC 2283

Query: 437  GPGGGSLVCT--------PASCGLGEVCGL-------LPSGQHGCQPVS 470
               G  + CT          +CGL EV  L        P  +  C PVS
Sbjct: 2284 -LSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVS 2331



 Score = 32.0 bits (71), Expect = 4.3
 Identities = 49/178 (27%), Positives = 62/178 (34%), Gaps = 40/178 (22%)

Query: 694  CLLDACQV-QGHPGGLCPAVATYVAACQAAGAQLGEWRRPDF-CPLQCPAHSHYELCGDS 751
            CL  AC+V  G P G         ++ ++ G+Q   W  P+  C +        E+    
Sbjct: 2494 CLPSACEVVTGSPRG------DSQSSWKSVGSQ---WASPENPCLINECVRVKEEVFIQQ 2544

Query: 752  CPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGP 811
              VSCP L  P           VC +GF LS  T      C C         G V  PG 
Sbjct: 2545 RNVSCPQLEVP-----------VCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGK 2593

Query: 812  ----ECERRCECGPGGHVTCQEGAACGPHEECRLED------GVQACHATG--CGRCL 857
                +    C C        Q G   G   ECR         G +  + TG  CGRCL
Sbjct: 2594 TVMIDVCTTCRC------MVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCL 2645


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  304 bits (779), Expect = 3e-82
 Identities = 310/1265 (24%), Positives = 480/1265 (37%), Gaps = 209/1265 (16%)

Query: 75   CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
            C  WG+ HY +FDG  F F G C+Y  A+  C G   +    F V  K       A + V
Sbjct: 37   CSTWGNFHYKTFDGDVFRFPGLCDYNFASD-CRGSYKE----FAVHLKRGPGQAEAPAGV 91

Query: 135  RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVA--DGRISVAQGASKALLVADFGLQ 192
              +        ++I  D I   R   VL    VS       + + +  +   + +  GL 
Sbjct: 92   ESIL-------LTIKDDTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLT 144

Query: 193  VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 252
            + ++    + + L + +    CGLCG+ +   +  +   +G L   +  +G   +    D
Sbjct: 145  LMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLFSPLE-FGNMQKINQPD 203

Query: 253  PLCWDECRGSCP-TCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV 311
             +C D      P +C E R E       C  L   T   F  C   VP E + + C  D 
Sbjct: 204  VVCEDPEEEVAPASCSEHRAE-------CERLL--TAEAFADCQDLVPLEPYLRACQQDR 254

Query: 312  CMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPS 371
            C   G    +C  +A +   C  AG    +WR    C  TCP N  Y   G PC  +C  
Sbjct: 255  CRCPGGDTCVCSTVAEFSRQCSHAGGRPGNWRTATLCPKTCPGNLVYLESGSPCMDTC-- 312

Query: 372  PAPLTTPAVCEGPCVEGCQCDAGFV---LSADRCVPLNNGCGCWANGTYHEAGSEFWADG 428
             + L   ++CE   ++GC C  G V   +    CVP++  C C  +G  +  G E   D 
Sbjct: 313  -SHLEVSSLCEEHRMDGCFCPEGTVYDDIGDSGCVPVSQ-CHCRLHGHLYTPGQEITND- 369

Query: 429  TCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGH 488
             C Q C C    G  VC    C                       C   G  H  T DG 
Sbjct: 370  -CEQ-CVC--NAGRWVCKDLPC--------------------PGTCALEGGSHITTFDGK 405

Query: 489  RFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGS-QAVSYTRSVTLQIYNHSLTLSA 547
             + F G C Y+L+   H      +++ +       GS    +  ++V L        +  
Sbjct: 406  TYTFHGDCYYVLAKGDHN-----DSYALLGELAPCGSTDKQTCLKTVVLLADKKKNVVVF 460

Query: 548  RWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAA 607
            +    + ++ + V LP    S      S   ++V+   G+ L       ++L V    A+
Sbjct: 461  KSDGSVLLNELQVNLPHVTASFSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQAS 520

Query: 608  --SLCGLCGNYNQDPADDLKAVGGKPAGWQVGGA---QGCGECVSKP--CPSPCTPEQQE 660
               + GLCGN+N    DD K   G       G A   +    C  K      PC+   + 
Sbjct: 521  QGQVQGLCGNFNGLEGDDFKTASGLVEATGAGFANTWKAQSSCHDKLDWLDDPCSLNIES 580

Query: 661  SFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ 720
            +      C ++  T+ P   CH  V PA+Y++ C  D C  Q +   LC A+++Y  AC 
Sbjct: 581  ANYAEHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSSYARACT 640

Query: 721  AAGAQLGEWRRPDFCPL---QCPAHSHYELCGDSCPVSCPSLSAPEGCESACRE------ 771
            A G  L  WR    C      CP    +     +C  +C SLS     +S C E      
Sbjct: 641  AKGVMLWGWRE-HVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSE---ADSHCLEGFAPVD 696

Query: 772  GCVC-DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPG-------- 822
            GC C D  F+     CVP+ +C C H G Y   G+V       E RC C  G        
Sbjct: 697  GCGCPDHTFLDEKGRCVPLAKCSCYHRGLYLEAGDVVV---RQEERCVCRDGRLHCRQIR 753

Query: 823  --------------------------GHVTCQEGAACGPHEEC---------RLEDGVQA 847
                                        ++CQ  AA   H EC          ++DG   
Sbjct: 754  LIGQSCTAPKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPDGLMDDGRGG 813

Query: 848  C--------------HATG------CGRCLANGGI------------------HYITLDG 869
            C              +++G      C  C    G                   HYIT DG
Sbjct: 814  CVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDG 873

Query: 870  RVYDLHGSCSYVLAQ-VCHPKPGDEDFSIVLEKNAAGDL-----QRLLVTVAGQVVSLAQ 923
            + YD  G CSYV  Q  C        FSI+ E    G       + + + +    + L  
Sbjct: 874  KYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLED 933

Query: 924  GQQVTV---DGEAVALPVAVGRVRVTAE-GRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
              +V +   +G  VA          T E G+ +V++++ G+ +++D    + + +   ++
Sbjct: 934  KHRVVIQRDEGHHVAY--------TTREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYK 985

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G +CGLCGNF+   ++DF   +    SS   FG +W+   +         P     C   
Sbjct: 986  GTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTCPDVSTNPEP-----CSLN 1040

Query: 1040 ETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAY 1097
                  + + C  L++    F+ C + + P  ++  CV+D C+    GD    C ++A+Y
Sbjct: 1041 PHRRSWAEKQCSILKS--SVFSICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASY 1098

Query: 1098 TAACQAAGVAVKPWRTDSFCPLHC----PAHS---HYSICTRTCQGSCAALSGL-TGCTT 1149
               C   G  V  WRT   CP+ C    P H    HY  C      +C  ++G+ +  + 
Sbjct: 1099 AQECTKEGACVF-WRTPDLCPIFCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISV 1157

Query: 1150 RCFEGC--EC-DDRFLLSQGV--CIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSS 1204
               EGC   C  DR +  + +  C+    CGC     + P  +S+ T +  + C C++SS
Sbjct: 1158 SYLEGCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASVPTEETCKSCVCTNSS 1217

Query: 1205 GLTCQ 1209
             + C+
Sbjct: 1218 QVVCR 1222



 Score =  285 bits (730), Expect = 2e-76
 Identities = 268/1033 (25%), Positives = 402/1033 (38%), Gaps = 189/1033 (18%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 533
            C  WG+ HY T DG  F F G C+Y  ++ C G     + F V +      ++A +   S
Sbjct: 37   CSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRG---SYKEFAVHLKRGPGQAEAPAGVES 93

Query: 534  VTLQIYNHSLTLSARWPRKLQV-DGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592
            + L I + ++ L+    R L V +G  V+ P     LL    S A   V + +GL+L ++
Sbjct: 94   ILLTIKDDTIYLT----RHLAVLNGAVVSTPHYSPGLL-IEKSDAYTKVYSRAGLTLMWN 148

Query: 593  GDSFVRLRVPAAYAASLCGLCGNYNQ-DPADDLKAVGGKPAGWQVGGAQG-------CGE 644
             +  + L +   +    CGLCG+YN      +  + G   +  + G  Q        C +
Sbjct: 149  REDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLFSPLEFGNMQKINQPDVVCED 208

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
               +  P+ C+  + E       C  +   +   A C  LVP   Y + C  D C+  G 
Sbjct: 209  PEEEVAPASCSEHRAE-------CERLLTAEA-FADCQDLVPLEPYLRACQQDRCRCPGG 260

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
               +C  VA +   C  AG + G WR    CP  CP +  Y   G  C  +C  L     
Sbjct: 261  DTCVCSTVAEFSRQCSHAGGRPGNWRTATLCPKTCPGNLVYLESGSPCMDTCSHLEVSSL 320

Query: 765  CESACREGCVCDAGFVLS--GDT-CVPVGQCGC-LHDGRYYPLGEVFYPGPECERRCECG 820
            CE    +GC C  G V    GD+ CVPV QC C LH       G ++ PG E    C   
Sbjct: 321  CEEHRMDGCFCPEGTVYDDIGDSGCVPVSQCHCRLH-------GHLYTPGQEITNDC--- 370

Query: 821  PGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCS 879
                            E+C    G   C    C G C   GG H  T DG+ Y  HG C 
Sbjct: 371  ----------------EQCVCNAGRWVCKDLPCPGTCALEGGSHITTFDGKTYTFHGDCY 414

Query: 880  YVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTV----DGEAVA 935
            YVLA+  H    ++ ++++ E    G   +   T    VV LA  ++  V    DG  + 
Sbjct: 415  YVLAKGDH----NDSYALLGELAPCGSTDK--QTCLKTVVLLADKKKNVVVFKSDGSVLL 468

Query: 936  LPVAVGRVRVTA-------EGRNMVLQTTKGLRLLFD--GDAHLLMSIPSPFRGRLCGLC 986
              + V    VTA          ++++    G+RL         L +++    +G++ GLC
Sbjct: 469  NELQVNLPHVTASFSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLC 528

Query: 987  GNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYES 1046
            GNFNG   DDF   +G   ++   F   W+   S   C +       P  L  E+A Y +
Sbjct: 529  GNFNGLEGDDFKTASGLVEATGAGFANTWKAQSS---CHDKLDWLDDPCSLNIESANY-A 584

Query: 1047 NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGV 1106
               C  L+  + PF  C + + P+EY+++C YD C  + ++  LC +L++Y  AC A GV
Sbjct: 585  EHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGV 644

Query: 1107 AVKPWRTDSFCPL---HCPAHSHYSICTRTCQGSCAALSGLTGCTTRCF---EGCECDDR 1160
             +  WR +  C      CP    +     TCQ +C +LS         F   +GC C D 
Sbjct: 645  MLWGWR-EHVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSEADSHCLEGFAPVDGCGCPDH 703

Query: 1161 -FLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC------------------- 1200
             FL  +G C+P+  C C H G YL     ++  +  ERC C                   
Sbjct: 704  TFLDEKGRCVPLAKCSCYHRGLYLEAGDVVVRQE--ERCVCRDGRLHCRQIRLIGQSCTA 761

Query: 1201 ---------------SSSSGLTCQ--AAG-----CPPGRVC------------------- 1219
                           S    L+CQ  AAG     C  G VC                   
Sbjct: 762  PKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPDGLMDDGRGGCVVEKECP 821

Query: 1220 ------------EVKAEARNCWATRG--LCVLSVGANLTTFDGARGATTSPG-VYELSSR 1264
                        ++K +   C   RG  +C  +V     +  G+    T  G  Y+    
Sbjct: 822  CVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGH 881

Query: 1265 CPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQD---GMVTLTPNKGVWVNGLRVDLP 1321
            C            VA    C G+  ++G   I  ++   G   +T +K + +   R +L 
Sbjct: 882  C----------SYVAVQDYC-GQNSSLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELK 930

Query: 1322 AEKLASVSVSRTPDGS-----------LLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCG 1370
             E    V + R                L+V    G+ V       V + ++  + G +CG
Sbjct: 931  LEDKHRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYKGTVCG 990

Query: 1371 ACGNFDGDQTNDW 1383
             CGNFD    ND+
Sbjct: 991  LCGNFDHRSNNDF 1003



 Score =  139 bits (350), Expect = 2e-32
 Identities = 121/484 (25%), Positives = 191/484 (39%), Gaps = 76/484 (15%)

Query: 385  CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLV 444
            CV GC C  G +        +   C C  N   + +G++   D  C+  C C  G    V
Sbjct: 796  CVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVD--CNT-CTCKRG--RWV 850

Query: 445  CTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPC 504
            CT A C             HG        C  +G  HY+T DG  +DF G C Y+     
Sbjct: 851  CTQAVC-------------HGT-------CSIYGSGHYITFDGKYYDFDGHCSYVAVQDY 890

Query: 505  HGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD-GVFVALP 563
             G      +F++   N   G+  V+ ++++ + +    L L  +    +Q D G  VA  
Sbjct: 891  CGQNSSLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYT 950

Query: 564  FQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADD 623
                        G  +VV +++G+ + +D  + V +++  +Y  ++CGLCGN++    +D
Sbjct: 951  --------TREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNND 1002

Query: 624  LKAVGGKPAGWQVGGAQGCGECVSKP----CPSPCTPEQQESFGGPDACGVISATDGPLA 679
                       ++       E  + P     P PC+            C ++ ++    +
Sbjct: 1003 FTTRDHMVVSSELDFGNSWKEAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSS--VFS 1060

Query: 680  PCHGLVPPAQYFQGCLLDACQVQ--GHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPL 737
             CH  V P  +++ C+ D+C     G     C AVA+Y   C   GA +  WR PD CP+
Sbjct: 1061 ICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQECTKEGACV-FWRTPDLCPI 1119

Query: 738  QC----PAHS---HYELCGDSCPVSCP---------SLSAPEGCESAC-REGCVCDAGFV 780
             C    P H    HYE CG+    +C          S+S  EGC   C ++  + +    
Sbjct: 1120 FCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDL- 1178

Query: 781  LSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTC-----------QE 829
                 CV   +CGC  +  +YP G    P  E  + C C     V C           Q+
Sbjct: 1179 ---KKCVTADKCGCYVEDTHYPPG-ASVPTEETCKSCVCTNSSQVVCRPEEGKILNQTQD 1234

Query: 830  GAAC 833
            GA C
Sbjct: 1235 GAFC 1238



 Score =  130 bits (326), Expect = 1e-29
 Identities = 114/406 (28%), Positives = 169/406 (41%), Gaps = 38/406 (9%)

Query: 57   TCKEQGGQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLT 115
            TC  + G+ VC       TC ++G  HY +FDG+ +DF G C+YV     C   S+ G  
Sbjct: 841  TCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLG-- 898

Query: 116  PFTVTTKNENRGNPAVSYVRVVTVAALGTNISIH-KDEIGKVRVNGVLTALPVSVADGRI 174
             F++ T+N   G   V+  + + +    T + +  K  +   R  G   A       G+ 
Sbjct: 899  SFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTREV-GQY 957

Query: 175  SVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGT 234
             V + ++        G+ V +D    V + L  SY G VCGLCGN D   NND    +  
Sbjct: 958  LVVESST--------GIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHM 1009

Query: 235  LAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTC 294
            +  S   +G SW+     P C D      P C  +   +      C  L       F+ C
Sbjct: 1010 VVSSELDFGNSWKEA---PTCPDVSTNPEP-CSLNPHRRSWAEKQCSILKSSV---FSIC 1062

Query: 295  HAHVPPESFFKGCVLDVCM--GGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 352
            H+ V P+ F++ CV D C    GGD +  C A+ASY   C   G  +  WR    C I C
Sbjct: 1063 HSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQECTKEGACV-FWRTPDLCPIFC 1121

Query: 353  PENS-------HYEVCGPPCPASCPSPAPL---TTPAVCEGPCVEGCQCDAG-FVLSADR 401
               +       HYE CG     +C +   +    + +  EG C   C  D   +     +
Sbjct: 1122 DYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEG-CYPRCPKDRPIYEEDLKK 1180

Query: 402  CVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTP 447
            CV  +  CGC+   T++  G+    + TC   C C      +VC P
Sbjct: 1181 CVTADK-CGCYVEDTHYPPGASVPTEETCKS-CVC-TNSSQVVCRP 1223



 Score =  127 bits (319), Expect = 8e-29
 Identities = 122/451 (27%), Positives = 172/451 (38%), Gaps = 56/451 (12%)

Query: 54   PQETCKEQGGQGVCLPNYEATCWLW---------GDPHYHSFDGRKFDFQGTCNYVLATT 104
            P  TC   G Q V + + +  CW W         GDPHY +FDG  + +QG C YVL   
Sbjct: 4452 PMPTCSN-GLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEE 4510

Query: 105  GCLGVSTQGLTPFTV-TTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLT 163
                V   G+         N+    P    VR  T   L   + +   ++ +V+VN    
Sbjct: 4511 ISPSVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMPMQV-QVQVNRQAV 4569

Query: 164  ALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH---GAVCGLCGNM 220
            ALP     G      G +  + + + G+ VSY+      V LP  YH       G CG  
Sbjct: 4570 ALPYK-KYGLEVYQSGINYVVDIPELGVLVSYN-GLSFSVRLP--YHRFGNNTKGQCGTC 4625

Query: 221  DRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCP---TCPEDRLEQYEGP 277
                ++D + P+G +  +       W       L  D  +  CP   +  +       G 
Sbjct: 4626 TNTTSDDCILPSGEIVSNCEAAADQW-------LVNDPSKPHCPHSSSTTKRPAVTVPGG 4678

Query: 278  GFCGPLAPGTGGP---------FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASY 328
            G   P    T  P         F  CHA VPP+ ++  CV D C   G   + C +L +Y
Sbjct: 4679 GKTTPHKDCTPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPGS-SLECASLQAY 4737

Query: 329  VAACQAAGVVIEDWRAQV--GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCV 386
             A C    + + DWR      C + CP +  Y+ CGP    +C S +      V     V
Sbjct: 4738 AALCAQQNICL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQNNTV----LV 4792

Query: 387  EGCQCDAG---FVLSADRCVPLNNGCGC-WANGTYHEAGSEFWADGTCSQWCRCGPGGGS 442
            EGC C  G   +    D CV     CGC   +    E G  F  D  C   C C  GG  
Sbjct: 4793 EGCFCPEGTMNYAPGFDVCV---KTCGCVGPDNVPREFGEHFEFD--CKN-CVCLEGGSG 4846

Query: 443  LVCTPASCGLGEVCGLLPSGQHGCQPVSTAE 473
            ++C P  C    V   +  G +    V+ A+
Sbjct: 4847 IICQPKRCSQKPVTHCVEDGTYLATEVNPAD 4877



 Score =  127 bits (318), Expect = 1e-28
 Identities = 114/425 (26%), Positives = 167/425 (39%), Gaps = 42/425 (9%)

Query: 816  RCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDL 874
            + EC P    TC  G      +  R+ED    C    C   C   G  HY+T DG  Y  
Sbjct: 4445 KVECEPPPMPTCSNGL-----QPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSY 4499

Query: 875  HGSCSYVLAQVCHPKPGDEDFSIVLEK-----NAAGDLQRLLV-------TVAGQVVSLA 922
             G+C+YVL +     P  ++F + ++      N      R L+        +   V  + 
Sbjct: 4500 QGNCTYVLVE--EISPSVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMP 4557

Query: 923  QGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTK-GLRLLFDGDAHLLMSIPSP---F 978
               QV V+ +AVALP     + V   G N V+   + G+ + ++G   L  S+  P   F
Sbjct: 4558 MQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDIPELGVLVSYNG---LSFSVRLPYHRF 4614

Query: 979  RGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSK-GCGEGCGPQGCPVCL 1037
                 G CG      SDD +LP+G   S+ E     W V   SK  C         P   
Sbjct: 4615 GNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVT 4674

Query: 1038 AE---ETAPYES---NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLC 1091
                 +T P++    +  C  +++    FA C A++ P  Y+  CV+D C   G  +  C
Sbjct: 4675 VPGGGKTTPHKDCTPSPLCQLIKD--SLFAQCHALVPPQHYYDACVFDSCFMPG-SSLEC 4731

Query: 1092 RSLAAYTAACQAAGVAVKPWR--TDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT 1149
             SL AY A C    + +  WR  T   C + CP+H  Y  C    + +C + S      T
Sbjct: 4732 ASLQAYAALCAQQNICL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQN-NT 4789

Query: 1150 RCFEGCECDDRFL-LSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTC 1208
               EGC C +  +  + G  + V+ CGC                DC         SG+ C
Sbjct: 4790 VLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVPREFGEHFEFDCKNCVCLEGGSGIIC 4849

Query: 1209 QAAGC 1213
            Q   C
Sbjct: 4850 QPKRC 4854



 Score =  122 bits (307), Expect = 2e-27
 Identities = 137/480 (28%), Positives = 190/480 (39%), Gaps = 59/480 (12%)

Query: 56  ETCKEQGGQGVC--LPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLA------TTGCL 107
           E C    G+ VC  LP    TC L G  H  +FDG+ + F G C YVLA      +   L
Sbjct: 371 EQCVCNAGRWVCKDLP-CPGTCALEGGSHITTFDGKTYTFHGDCYYVLAKGDHNDSYALL 429

Query: 108 GVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPV 167
           G     L P   T K             VV +A    N+ + K + G V +N +   LP 
Sbjct: 430 GE----LAPCGSTDKQ-------TCLKTVVLLADKKKNVVVFKSD-GSVLLNELQVNLPH 477

Query: 168 SVADGRISVAQGASKALLVA---DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNP 224
             A    SV + +S  ++V+      LQV      ++ VTL  +  G V GLCGN +   
Sbjct: 478 VTAS--FSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGLE 535

Query: 225 NNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLA 284
            +D    +G +  +   +  +W+A      C D+       C  +         +C  L 
Sbjct: 536 GDDFKTASGLVEATGAGFANTWKAQS---SCHDKLDWLDDPCSLNIESANYAEHWCS-LL 591

Query: 285 PGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRA 344
             T  PF  CH+ V P  ++K C  D C    + D LC AL+SY  AC A GV++  WR 
Sbjct: 592 KKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGVMLWGWRE 651

Query: 345 QVGCEI---TCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQC-DAGFVLSAD 400
            V C     +CP +  +      C  +C S +   +  +     V+GC C D  F+    
Sbjct: 652 HV-CNKDVGSCPNSQVFLYNLTTCQQTCRSLSEADSHCLEGFAPVDGCGCPDHTFLDEKG 710

Query: 401 RCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLP 460
           RCVPL   C C+  G Y EAG     D    Q  RC    G L C      +G+ C   P
Sbjct: 711 RCVPLAK-CSCYHRGLYLEAG-----DVVVRQEERCVCRDGRLHCRQIRL-IGQSC-TAP 762

Query: 461 SGQHGCQPVS--------TAECQAWGDPHY--------VTLDGHRFDFQGTCEYLLSAPC 504
                C  ++           CQ     +Y        V  DG   D +G C      PC
Sbjct: 763 KIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPDGLMDDGRGGCVVEKECPC 822



 Score =  117 bits (294), Expect = 6e-26
 Identities = 119/428 (27%), Positives = 183/428 (42%), Gaps = 56/428 (13%)

Query: 459  LPSGQHGCQPVSTAE-------------CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCH 505
            +P+  +G QPV   +             C  WGDPHYVT DG  + +QG C Y+L     
Sbjct: 4453 MPTCSNGLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEIS 4512

Query: 506  GPPLGAENFTVTVANEH-RGSQAVSYTRSVTLQIYNHSLTLSA----RWPRKLQVDGVFV 560
                  +NF V + N H   +  VS  R++ ++     + +          ++QV+   V
Sbjct: 4513 P---SVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAV 4569

Query: 561  ALPFQLDSLLHAHLSGADVVVTTTS-GLSLAFDGDSFVRLRVP-AAYAASLCGLCGNYNQ 618
            ALP++    L  + SG + VV     G+ ++++G SF  +R+P   +  +  G CG    
Sbjct: 4570 ALPYKKYG-LEVYQSGINYVVDIPELGVLVSYNGLSF-SVRLPYHRFGNNTKGQCGTCTN 4627

Query: 619  DPADDLKAVGGK-PAGWQVGGAQGCGECVSKP-CPSPCTPEQQESF---GGPDACGVISA 673
              +DD     G+  +  +    Q      SKP CP   +  ++ +    GG         
Sbjct: 4628 TTSDDCILPSGEIVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDC 4687

Query: 674  TDGPL---------APCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGA 724
            T  PL         A CH LVPP  Y+  C+ D+C + G     C ++  Y A C     
Sbjct: 4688 TPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPG-SSLECASLQAYAALCAQQNI 4746

Query: 725  QLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG---F 779
             L +WR      C ++CP+H  Y+ CG +   +C S S+ +   +   EGC C  G   +
Sbjct: 4747 CL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQN-NTVLVEGCFCPEGTMNY 4804

Query: 780  VLSGDTCVPVGQCGCL-HDGRYYPLGEVFYPGPECERRCECGPGGH-VTCQ-EGAACGPH 836
                D CV    CGC+  D      GE F    +C + C C  GG  + CQ +  +  P 
Sbjct: 4805 APGFDVCVKT--CGCVGPDNVPREFGEHF--EFDC-KNCVCLEGGSGIICQPKRCSQKPV 4859

Query: 837  EECRLEDG 844
              C +EDG
Sbjct: 4860 THC-VEDG 4866


>gi|239755901 PREDICTED: chromosome 12 open reading frame 64 [Homo
            sapiens]
          Length = 2250

 Score =  303 bits (777), Expect = 6e-82
 Identities = 304/1177 (25%), Positives = 458/1177 (38%), Gaps = 196/1177 (16%)

Query: 48   HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 156
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141

Query: 157  RVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 216
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197

Query: 217  CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 276
            CGN +   ++D +         I ++  SW     D           P      +  +E 
Sbjct: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEA 257

Query: 277  PGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335
              F C  L      PF +CH ++ P  +   CV D+C    D +  C+A   Y  AC  A
Sbjct: 258  IFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHA 313

Query: 336  GVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGP---CVEGCQC 391
            G  I+DWR     C   C ++  +  C   CP +C      T    C G    C++GC C
Sbjct: 314  GYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQCLGSNLHCLDGCYC 367

Query: 392  DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCG 451
              G V+    C+ L N C C  +G  +  GS+   +  C++ C C   GG   CT   C 
Sbjct: 368  PDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV--GGVWNCTEQDC- 420

Query: 452  LGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGA 511
                            PV   +C   GD H+ T DG  + F G C+Y+L         G 
Sbjct: 421  ----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT-----GK 456

Query: 512  ENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQVDGVFVALP---F 564
            + FT+T+       +  +   +S+TL +   +N  +TL           G  +  P   F
Sbjct: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR--------GGQILTSPNQGF 508

Query: 565  QLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAASLCGLCGNYNQDPA 621
             L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+     GLCG +N +  
Sbjct: 509  NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRRTLGLCGTFNGNIR 567

Query: 622  DDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISA 673
            DD  +  G   G        W+V     C   V  P   PC   QQ + G    C VI  
Sbjct: 568  DDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ-NIGYAAHCDVIHQ 624

Query: 674  TDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD 733
                 APCH  + P  Y+Q C  DAC+       LC A+A Y   C   G  +    +  
Sbjct: 625  E--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPIDFRTQIS 680

Query: 734  FCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG--FVLSGDTCVPVGQ 791
            FC + C     Y  C   C  SC SLS+PE C   C EGC C  G  +  + + CVP+  
Sbjct: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740

Query: 792  CGCLHDGRYYPLGEVF--------------------------------------YPGPE- 812
            C C + G  Y  GE+                                       +P PE 
Sbjct: 741  CRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPEL 800

Query: 813  ------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLA 858
                  CE  C        C P     C  G  C P   CR   G+  C    C   C  
Sbjct: 801  PAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RGMFNCTYYPCPAVCTI 855

Query: 859  NGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQV 918
             G  HY + DG  YD    C   L +       D D S++ +     D    +V     +
Sbjct: 856  YGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKKCFDND--IVCSKSVL 909

Query: 919  VSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------MVLQTTKGLRLLFDGD 967
            +S+   +    D      P    +     E ++           +V    K + +L+D  
Sbjct: 910  ISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRK 964

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEG 1027
              + + +   ++ +L GLCGNF+   S+D    N     +   FG +W + G  +   E 
Sbjct: 965  TTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL-GQCESPDET 1023

Query: 1028 CGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQK-- 1084
              P     C A +   PY   E C  L +    FA+C+ V+  + + + C  D C     
Sbjct: 1024 IKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTSFAKNCHEDTCNCNLG 1075

Query: 1085 GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
            GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 1076 GDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111



 Score =  255 bits (652), Expect = 2e-67
 Identities = 227/841 (26%), Positives = 343/841 (40%), Gaps = 99/841 (11%)

Query: 424  FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 477
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 536
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124

Query: 537  QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 596
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181

Query: 597  VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 648
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240

Query: 649  PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 706
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298

Query: 707  GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356

Query: 765  CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 824
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404

Query: 825  VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 883
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451

Query: 884  QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 933
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507

Query: 934  VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 990
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563

Query: 991  GNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 1050
            GN  DDF+ P+G    + +    AWRV  SS        P   P  + ++   Y ++  C
Sbjct: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619

Query: 1051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675

Query: 1111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 1168
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735

Query: 1169 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 1227
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792

Query: 1228 C 1228
            C
Sbjct: 793  C 793



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 100/440 (22%), Positives = 166/440 (37%), Gaps = 73/440 (16%)

Query: 818  ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 877
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462

Query: 878  CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 927
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518

Query: 928  TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 983
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575

Query: 984  --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRVPGS----SKGCGEGCGPQGCP 1034
              GLCG  N +  DD  + NG+  +++E  G    +W +  S     +     C    C 
Sbjct: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635

Query: 1035 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 1094
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677

Query: 1095 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 1152
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736

Query: 1153 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 1206
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 1737 EDCVCKVGTVLHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795

Query: 1207 TCQAAGC--PPGRVCEVKAE 1224
                  C   P  VCE +AE
Sbjct: 1796 IPIEPDCDEEPTPVCEREAE 1815



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 88/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 532
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 533  SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556

Query: 593  G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 635
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613

Query: 636  VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 694
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662

Query: 695  LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 754
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718

Query: 755  SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 794
                     G  S    RE CVC  G VL       C+P  +C C
Sbjct: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTVLHRPHSAQCIPEKECAC 1763



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 89/389 (22%), Positives = 139/389 (35%), Gaps = 54/389 (13%)

Query: 61   QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118
            Q    +C P +E  C   +  +    +FDG         +Y+L       V   G     
Sbjct: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYIL-------VRIPGEIIVA 1477

Query: 119  VTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGRI 174
               K      P+   +  +    L     IHK  +     KV V+ ++  LP S  +  +
Sbjct: 1478 HIEKCSMNQAPS-GRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE--L 1534

Query: 175  SVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P+
Sbjct: 1535 SIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDPD 1588

Query: 226  NDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGP 282
            +D    NGT+  +   I ++  SW       +     R     C E    Q      C  
Sbjct: 1589 DDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CID 1639

Query: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDW 342
            L       F  CH  V PE F +   ++           C AL++YVA C    + I+ W
Sbjct: 1640 LL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-W 1693

Query: 343  RAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---SA 399
            R    C ++CPE   Y+ C  PC A             C     E C C  G VL    +
Sbjct: 1694 RTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTVLHRPHS 1752

Query: 400  DRCVPLNNGCGCWANGTYHEAGSEFWADG 428
             +C+P    C C  +        E W  G
Sbjct: 1753 AQCIP-EKECACTDSEDQPRTAGEIWNGG 1780



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81

Query: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 1305
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133

Query: 1306 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 1364
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190

Query: 1365 AGKLCGACGNFDGDQTNDWHDSQE 1388
             GK CG CGN++  Q++D+   QE
Sbjct: 191  KGKSCGLCGNYNDIQSDDFIILQE 214


>gi|239750386 PREDICTED: chromosome 12 open reading frame 64 [Homo
            sapiens]
          Length = 2250

 Score =  303 bits (777), Expect = 6e-82
 Identities = 304/1177 (25%), Positives = 458/1177 (38%), Gaps = 196/1177 (16%)

Query: 48   HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 156
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141

Query: 157  RVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 216
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197

Query: 217  CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 276
            CGN +   ++D +         I ++  SW     D           P      +  +E 
Sbjct: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEA 257

Query: 277  PGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335
              F C  L      PF +CH ++ P  +   CV D+C    D +  C+A   Y  AC  A
Sbjct: 258  IFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHA 313

Query: 336  GVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGP---CVEGCQC 391
            G  I+DWR     C   C ++  +  C   CP +C      T    C G    C++GC C
Sbjct: 314  GYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQCLGSNLHCLDGCYC 367

Query: 392  DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCG 451
              G V+    C+ L N C C  +G  +  GS+   +  C++ C C   GG   CT   C 
Sbjct: 368  PDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV--GGVWNCTEQDC- 420

Query: 452  LGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGA 511
                            PV   +C   GD H+ T DG  + F G C+Y+L         G 
Sbjct: 421  ----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT-----GK 456

Query: 512  ENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQVDGVFVALP---F 564
            + FT+T+       +  +   +S+TL +   +N  +TL           G  +  P   F
Sbjct: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR--------GGQILTSPNQGF 508

Query: 565  QLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAASLCGLCGNYNQDPA 621
             L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+     GLCG +N +  
Sbjct: 509  NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRRTLGLCGTFNGNIR 567

Query: 622  DDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISA 673
            DD  +  G   G        W+V     C   V  P   PC   QQ + G    C VI  
Sbjct: 568  DDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ-NIGYAAHCDVIHQ 624

Query: 674  TDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD 733
                 APCH  + P  Y+Q C  DAC+       LC A+A Y   C   G  +    +  
Sbjct: 625  E--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPIDFRTQIS 680

Query: 734  FCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG--FVLSGDTCVPVGQ 791
            FC + C     Y  C   C  SC SLS+PE C   C EGC C  G  +  + + CVP+  
Sbjct: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740

Query: 792  CGCLHDGRYYPLGEVF--------------------------------------YPGPE- 812
            C C + G  Y  GE+                                       +P PE 
Sbjct: 741  CRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPEL 800

Query: 813  ------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLA 858
                  CE  C        C P     C  G  C P   CR   G+  C    C   C  
Sbjct: 801  PAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RGMFNCTYYPCPAVCTI 855

Query: 859  NGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQV 918
             G  HY + DG  YD    C   L +       D D S++ +     D    +V     +
Sbjct: 856  YGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKKCFDND--IVCSKSVL 909

Query: 919  VSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------MVLQTTKGLRLLFDGD 967
            +S+   +    D      P    +     E ++           +V    K + +L+D  
Sbjct: 910  ISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRK 964

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEG 1027
              + + +   ++ +L GLCGNF+   S+D    N     +   FG +W + G  +   E 
Sbjct: 965  TTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL-GQCESPDET 1023

Query: 1028 CGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQK-- 1084
              P     C A +   PY   E C  L +    FA+C+ V+  + + + C  D C     
Sbjct: 1024 IKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTSFAKNCHEDTCNCNLG 1075

Query: 1085 GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
            GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 1076 GDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111



 Score =  255 bits (652), Expect = 2e-67
 Identities = 227/841 (26%), Positives = 343/841 (40%), Gaps = 99/841 (11%)

Query: 424  FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 477
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 536
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124

Query: 537  QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 596
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181

Query: 597  VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 648
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240

Query: 649  PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 706
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298

Query: 707  GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356

Query: 765  CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 824
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404

Query: 825  VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 883
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451

Query: 884  QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 933
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507

Query: 934  VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 990
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563

Query: 991  GNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 1050
            GN  DDF+ P+G    + +    AWRV  SS        P   P  + ++   Y ++  C
Sbjct: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619

Query: 1051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675

Query: 1111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 1168
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735

Query: 1169 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 1227
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792

Query: 1228 C 1228
            C
Sbjct: 793  C 793



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 100/440 (22%), Positives = 166/440 (37%), Gaps = 73/440 (16%)

Query: 818  ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 877
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462

Query: 878  CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 927
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518

Query: 928  TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 983
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575

Query: 984  --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRVPGS----SKGCGEGCGPQGCP 1034
              GLCG  N +  DD  + NG+  +++E  G    +W +  S     +     C    C 
Sbjct: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635

Query: 1035 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 1094
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677

Query: 1095 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 1152
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736

Query: 1153 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 1206
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 1737 EDCVCKVGTILHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795

Query: 1207 TCQAAGC--PPGRVCEVKAE 1224
                  C   P  VCE +AE
Sbjct: 1796 IPIEPDCDEEPTPVCEREAE 1815



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 87/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 532
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 533  SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556

Query: 593  G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 635
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613

Query: 636  VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 694
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662

Query: 695  LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 754
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718

Query: 755  SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 794
                     G  S    RE CVC  G +L       C+P  +C C
Sbjct: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 88/389 (22%), Positives = 139/389 (35%), Gaps = 54/389 (13%)

Query: 61   QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118
            Q    +C P +E  C   +  +    +FDG         +Y+L       V   G     
Sbjct: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYIL-------VRIPGEIIVA 1477

Query: 119  VTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGRI 174
               K      P+   +  +    L     IHK  +     KV V+ ++  LP S  +  +
Sbjct: 1478 HIEKCSMNQAPS-GRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE--L 1534

Query: 175  SVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P+
Sbjct: 1535 SIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDPD 1588

Query: 226  NDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGP 282
            +D    NGT+  +   I ++  SW       +     R     C E    Q      C  
Sbjct: 1589 DDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CID 1639

Query: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDW 342
            L       F  CH  V PE F +   ++           C AL++YVA C    + I+ W
Sbjct: 1640 LL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-W 1693

Query: 343  RAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---SA 399
            R    C ++CPE   Y+ C  PC A             C     E C C  G +L    +
Sbjct: 1694 RTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPHS 1752

Query: 400  DRCVPLNNGCGCWANGTYHEAGSEFWADG 428
             +C+P    C C  +        E W  G
Sbjct: 1753 AQCIP-EKECACTDSEDQPRTAGEIWNGG 1780



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81

Query: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 1305
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133

Query: 1306 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 1364
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190

Query: 1365 AGKLCGACGNFDGDQTNDWHDSQE 1388
             GK CG CGN++  Q++D+   QE
Sbjct: 191  KGKSCGLCGNYNDIQSDDFIILQE 214


>gi|239744688 PREDICTED: hypothetical protein LOC283310 [Homo sapiens]
          Length = 2250

 Score =  303 bits (777), Expect = 6e-82
 Identities = 304/1177 (25%), Positives = 458/1177 (38%), Gaps = 196/1177 (16%)

Query: 48   HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 98
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87

Query: 99   YVLATTGCLGVSTQGLTPFTVTTKNENR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 156
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141

Query: 157  RVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 216
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197

Query: 217  CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 276
            CGN +   ++D +         I ++  SW     D           P      +  +E 
Sbjct: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEA 257

Query: 277  PGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335
              F C  L      PF +CH ++ P  +   CV D+C    D +  C+A   Y  AC  A
Sbjct: 258  IFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHA 313

Query: 336  GVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGP---CVEGCQC 391
            G  I+DWR     C   C ++  +  C   CP +C      T    C G    C++GC C
Sbjct: 314  GYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQCLGSNLHCLDGCYC 367

Query: 392  DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCG 451
              G V+    C+ L N C C  +G  +  GS+   +  C++ C C   GG   CT   C 
Sbjct: 368  PDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV--GGVWNCTEQDC- 420

Query: 452  LGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGA 511
                            PV   +C   GD H+ T DG  + F G C+Y+L         G 
Sbjct: 421  ----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT-----GK 456

Query: 512  ENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQVDGVFVALP---F 564
            + FT+T+       +  +   +S+TL +   +N  +TL           G  +  P   F
Sbjct: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR--------GGQILTSPNQGF 508

Query: 565  QLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAASLCGLCGNYNQDPA 621
             L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+     GLCG +N +  
Sbjct: 509  NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRRTLGLCGTFNGNIR 567

Query: 622  DDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISA 673
            DD  +  G   G        W+V     C   V  P   PC   QQ + G    C VI  
Sbjct: 568  DDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ-NIGYAAHCDVIHQ 624

Query: 674  TDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD 733
                 APCH  + P  Y+Q C  DAC+       LC A+A Y   C   G  +    +  
Sbjct: 625  E--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPIDFRTQIS 680

Query: 734  FCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG--FVLSGDTCVPVGQ 791
            FC + C     Y  C   C  SC SLS+PE C   C EGC C  G  +  + + CVP+  
Sbjct: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740

Query: 792  CGCLHDGRYYPLGEVF--------------------------------------YPGPE- 812
            C C + G  Y  GE+                                       +P PE 
Sbjct: 741  CRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPEL 800

Query: 813  ------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLA 858
                  CE  C        C P     C  G  C P   CR   G+  C    C   C  
Sbjct: 801  PAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RGMFNCTYYPCPAVCTI 855

Query: 859  NGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQV 918
             G  HY + DG  YD    C   L +       D D S++ +     D    +V     +
Sbjct: 856  YGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKKCFDND--IVCSKSVL 909

Query: 919  VSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------MVLQTTKGLRLLFDGD 967
            +S+   +    D      P    +     E ++           +V    K + +L+D  
Sbjct: 910  ISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRK 964

Query: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEG 1027
              + + +   ++ +L GLCGNF+   S+D    N     +   FG +W + G  +   E 
Sbjct: 965  TTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL-GQCESPDET 1023

Query: 1028 CGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQK-- 1084
              P     C A +   PY   E C  L +    FA+C+ V+  + + + C  D C     
Sbjct: 1024 IKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTSFAKNCHEDTCNCNLG 1075

Query: 1085 GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
            GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 1076 GDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111



 Score =  255 bits (652), Expect = 2e-67
 Identities = 227/841 (26%), Positives = 343/841 (40%), Gaps = 99/841 (11%)

Query: 424  FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 477
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 536
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124

Query: 537  QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 596
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181

Query: 597  VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 648
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240

Query: 649  PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 706
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298

Query: 707  GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356

Query: 765  CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 824
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404

Query: 825  VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 883
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451

Query: 884  QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 933
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507

Query: 934  VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 990
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563

Query: 991  GNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 1050
            GN  DDF+ P+G    + +    AWRV  SS        P   P  + ++   Y ++  C
Sbjct: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619

Query: 1051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675

Query: 1111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 1168
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735

Query: 1169 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 1227
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792

Query: 1228 C 1228
            C
Sbjct: 793  C 793



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 100/440 (22%), Positives = 166/440 (37%), Gaps = 73/440 (16%)

Query: 818  ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 877
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462

Query: 878  CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 927
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518

Query: 928  TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 983
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575

Query: 984  --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRVPGS----SKGCGEGCGPQGCP 1034
              GLCG  N +  DD  + NG+  +++E  G    +W +  S     +     C    C 
Sbjct: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635

Query: 1035 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 1094
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677

Query: 1095 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 1152
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736

Query: 1153 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 1206
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 1737 EDCVCKVGTILHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795

Query: 1207 TCQAAGC--PPGRVCEVKAE 1224
                  C   P  VCE +AE
Sbjct: 1796 IPIEPDCDEEPTPVCEREAE 1815



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 87/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 532
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 533  SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556

Query: 593  G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 635
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613

Query: 636  VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 694
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662

Query: 695  LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 754
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718

Query: 755  SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 794
                     G  S    RE CVC  G +L       C+P  +C C
Sbjct: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 88/389 (22%), Positives = 139/389 (35%), Gaps = 54/389 (13%)

Query: 61   QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118
            Q    +C P +E  C   +  +    +FDG         +Y+L       V   G     
Sbjct: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYIL-------VRIPGEIIVA 1477

Query: 119  VTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGRI 174
               K      P+   +  +    L     IHK  +     KV V+ ++  LP S  +  +
Sbjct: 1478 HIEKCSMNQAPS-GRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE--L 1534

Query: 175  SVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225
            S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P+
Sbjct: 1535 SIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDPD 1588

Query: 226  NDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGP 282
            +D    NGT+  +   I ++  SW       +     R     C E    Q      C  
Sbjct: 1589 DDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CID 1639

Query: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDW 342
            L       F  CH  V PE F +   ++           C AL++YVA C    + I+ W
Sbjct: 1640 LL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-W 1693

Query: 343  RAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---SA 399
            R    C ++CPE   Y+ C  PC A             C     E C C  G +L    +
Sbjct: 1694 RTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPHS 1752

Query: 400  DRCVPLNNGCGCWANGTYHEAGSEFWADG 428
             +C+P    C C  +        E W  G
Sbjct: 1753 AQCIP-EKECACTDSEDQPRTAGEIWNGG 1780



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81

Query: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 1305
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133

Query: 1306 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 1364
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190

Query: 1365 AGKLCGACGNFDGDQTNDWHDSQE 1388
             GK CG CGN++  Q++D+   QE
Sbjct: 191  KGKSCGLCGNYNDIQSDDFIILQE 214


>gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2852

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 73   PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 127

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 128  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 182

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 183  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 242

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 243  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 293

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 294  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 353

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 354  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 409

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 410  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 444

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 445  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 499

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 500  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 558

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 559  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 616

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 617  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 673

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 674  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 732

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 733  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 792

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 793  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 852

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 853  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 912

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 913  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 965

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 966  ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1021

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1022 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1077

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1078 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1133

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1134 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1170



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 44   GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 102

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 103  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 156

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 157  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 215

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 216  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 273

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 274  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 333

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 334  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 393

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 394  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 428

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 429  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 484

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 485  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 544

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 545  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 604

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 605  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 659

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 660  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 717

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 718  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 777

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 778  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 816



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 30   RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 89

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 90   FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 147

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 148  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 205

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 206  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 265

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 266  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 323

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 324  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 383

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 384  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 438

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 439  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 482

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 483  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 542

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 543  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 590



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 1953 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2006

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2053

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2054 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2108

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2109 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2168

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2169 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2226

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2227 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2270

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2271 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2326

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2327 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2385

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2386 QH-QCQAPDTIVPVDLGCPSPR 2406



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2012 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2068

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2069 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2122

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2123 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2169

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2170 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2222

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2223 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2277

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2278 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2335

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2336 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2390



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 891  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 939

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 940  ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 987

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 988  PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1099

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1100 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1156

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1157 AV-DWRTPRLCPYDC 1170



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2029 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2083

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2084 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2141

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2142 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2199

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2200 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2243

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2244 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2298

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2299 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2356

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2357 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2415

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2416 VALLLPTKDPCC 2427



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 811  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 868

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 869  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 901


>gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2924

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 145  PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 199

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 200  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 254

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 255  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 314

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 315  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 365

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 366  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 425

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 426  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 481

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 482  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 516

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 517  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 571

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 572  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 630

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 631  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 688

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 689  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 745

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 746  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 804

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 805  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 864

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 865  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 924

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 925  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 984

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 985  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 1037

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 1038 ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1093

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1094 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1149

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1150 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1205

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1206 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1242



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 116  GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 174

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 175  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 228

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 229  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 287

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 288  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 345

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 346  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 405

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 406  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 465

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 466  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 500

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 501  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 556

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 557  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 616

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 617  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 676

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 677  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 731

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 732  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 789

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 790  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 849

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 850  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 888



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 102  RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 161

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 162  FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 219

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 220  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 277

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 278  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 337

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 338  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 395

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 396  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 455

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 456  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 510

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 511  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 554

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 555  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 614

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 615  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 662



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 2025 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2078

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2125

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2126 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2180

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2181 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2240

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2241 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2298

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2299 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2342

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2343 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2398

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2399 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2457

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2458 QH-QCQAPDTIVPVDLGCPSPR 2478



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2084 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2140

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2141 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2194

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2195 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2241

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2242 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2294

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2295 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2349

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2350 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2407

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2408 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2462



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 963  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 1011

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 1012 ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 1059

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 1060 PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1171

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1172 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1228

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1229 AV-DWRTPRLCPYDC 1242



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2101 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2155

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2156 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2213

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2214 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2271

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2272 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2315

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2316 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2370

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2371 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2428

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2429 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2487

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2488 VALLLPTKDPCC 2499



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 883  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 940

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 941  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 973


>gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2852

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 73   PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 127

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 128  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 182

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 183  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 242

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 243  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 293

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 294  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 353

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 354  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 409

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 410  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 444

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 445  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 499

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 500  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 558

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 559  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 616

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 617  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 673

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 674  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 732

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 733  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 792

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 793  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 852

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 853  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 912

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 913  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 965

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 966  ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1021

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1022 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1077

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1078 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1133

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1134 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1170



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 44   GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 102

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 103  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 156

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 157  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 215

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 216  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 273

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 274  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 333

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 334  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 393

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 394  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 428

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 429  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 484

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 485  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 544

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 545  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 604

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 605  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 659

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 660  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 717

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 718  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 777

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 778  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 816



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 30   RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 89

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 90   FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 147

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 148  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 205

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 206  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 265

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 266  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 323

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 324  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 383

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 384  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 438

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 439  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 482

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 483  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 542

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 543  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 590



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 1953 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2006

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2053

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2054 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2108

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2109 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2168

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2169 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2226

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2227 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2270

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2271 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2326

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2327 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2385

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2386 QH-QCQAPDTIVPVDLGCPSPR 2406



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2012 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2068

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2069 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2122

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2123 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2169

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2170 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2222

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2223 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2277

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2278 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2335

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2336 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2390



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 891  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 939

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 940  ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 987

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 988  PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1099

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1100 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1156

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1157 AV-DWRTPRLCPYDC 1170



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2029 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2083

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2084 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2141

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2142 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2199

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2200 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2243

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2244 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2298

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2299 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2356

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2357 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2415

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2416 VALLLPTKDPCC 2427



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 811  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 868

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 869  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 901


>gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2924

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 145  PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 199

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 200  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 254

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 255  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 314

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 315  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 365

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 366  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 425

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 426  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 481

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 482  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 516

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 517  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 571

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 572  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 630

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 631  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 688

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 689  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 745

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 746  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 804

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 805  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 864

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 865  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 924

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 925  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 984

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 985  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 1037

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 1038 ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1093

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1094 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1149

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1150 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1205

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1206 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1242



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 116  GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 174

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 175  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 228

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 229  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 287

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 288  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 345

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 346  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 405

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 406  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 465

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 466  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 500

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 501  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 556

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 557  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 616

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 617  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 676

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 677  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 731

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 732  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 789

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 790  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 849

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 850  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 888



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 102  RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 161

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 162  FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 219

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 220  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 277

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 278  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 337

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 338  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 395

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 396  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 455

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 456  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 510

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 511  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 554

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 555  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 614

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 615  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 662



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 2025 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2078

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2125

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2126 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2180

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2181 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2240

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2241 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2298

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2299 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2342

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2343 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2398

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2399 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2457

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2458 QH-QCQAPDTIVPVDLGCPSPR 2478



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2084 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2140

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2141 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2194

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2195 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2241

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2242 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2294

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2295 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2349

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2350 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2407

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2408 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2462



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 963  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 1011

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 1012 ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 1059

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 1060 PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1171

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1172 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1228

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1229 AV-DWRTPRLCPYDC 1242



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2101 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2155

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2156 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2213

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2214 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2271

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2272 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2315

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2316 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2370

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2371 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2428

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2429 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2487

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2488 VALLLPTKDPCC 2499



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 883  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 940

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 941  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 973


>gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2852

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 73   PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 127

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 128  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 182

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 183  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 242

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 243  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 293

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 294  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 353

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 354  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 409

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 410  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 444

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 445  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 499

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 500  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 558

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 559  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 616

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 617  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 673

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 674  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 732

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 733  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 792

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 793  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 852

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 853  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 912

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 913  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 965

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 966  ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1021

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1022 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1077

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1078 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1133

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1134 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1170



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 44   GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 102

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 103  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 156

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 157  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 215

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 216  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 273

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 274  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 333

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 334  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 393

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 394  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 428

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 429  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 484

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 485  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 544

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 545  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 604

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 605  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 659

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 660  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 717

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 718  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 777

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 778  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 816



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 30   RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 89

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 90   FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 147

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 148  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 205

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 206  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 265

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 266  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 323

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 324  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 383

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 384  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 438

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 439  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 482

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 483  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 542

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 543  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 590



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 1953 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2006

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2053

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2054 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2108

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2109 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2168

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2169 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2226

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2227 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2270

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2271 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2326

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2327 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2385

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2386 QH-QCQAPDTIVPVDLGCPSPR 2406



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2012 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2068

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2069 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2122

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2123 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2169

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2170 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2222

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2223 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2277

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2278 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2335

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2336 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2390



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 891  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 939

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 940  ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 987

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 988  PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1099

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1100 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1156

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1157 AV-DWRTPRLCPYDC 1170



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2029 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2083

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2084 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2141

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2142 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2199

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2200 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2243

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2244 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2298

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2299 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2356

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2357 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2415

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2416 VALLLPTKDPCC 2427



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 811  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 868

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 869  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 901


>gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2924

 Score =  297 bits (761), Expect = 4e-80
 Identities = 305/1178 (25%), Positives = 452/1178 (38%), Gaps = 205/1178 (17%)

Query: 69   PNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENR-G 127
            P  ++ C  WG  H  +FDG  +   G  +Y L     +G        F++   N+ + G
Sbjct: 145  PERDSICRAWGQHHVETFDGLYYYLSGKGSYTL-----VGRHEPEGQSFSIQVHNDPQCG 199

Query: 128  NPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA 187
            +   +  R V++  +G    IH  +  +V   G+   LP  +   R+   Q A   ++  
Sbjct: 200  SSPYTCSRAVSLFFVGEQ-EIHLAK--EVTHGGMRVQLPHVMGSARLQ--QLAGYVIVRH 254

Query: 188  DFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 247
                 +++D    V + +     G   GLCGN + +P +D V  +G L   +  +  SW+
Sbjct: 255  QSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQ 314

Query: 248  --APGWDP------LCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVP 299
              AP   P      L    C    P   +   EQ E       L P    PF  CHA+V 
Sbjct: 315  EQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEAL-----LRP----PFDACHAYVS 365

Query: 300  PESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSH- 357
            P  F   C  D+C   GD    C+ALA Y  AC  AG  ++ WR Q+  C + C E +  
Sbjct: 366  PLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFT 425

Query: 358  YEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTY 417
            Y  C   CPASC    P  +    E  CV+GC C  G +     CV     C C  +GT 
Sbjct: 426  YNECIACCPASC---HPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAE-CPCEFHGTL 481

Query: 418  HEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAW 477
            +  GS    D  C+  C C    G   C+ A C                     AEC   
Sbjct: 482  YPPGSVVKED--CNT-CTC--TSGKWECSTAVC--------------------PAECSVT 516

Query: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRG-SQAVSYTRSVTL 536
            GD H+ T DG R+ F  TC+Y+L+         +  FTVT+ N   G +Q  +  +SV++
Sbjct: 517  GDIHFTTFDGRRYTFPATCQYILA-----KSRSSGTFTVTLQNAPCGLNQDGACVQSVSV 571

Query: 537  QIY---NHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
             ++      +TL+      L  D   +  P+  D+     LS   + V T  G+ + +D 
Sbjct: 572  ILHQDPRRQVTLTQAGD-VLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDR 630

Query: 594  DSF-VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPA--------GWQVGGAQGCGE 644
            +   + L+V   +     GLCG +N +  DD  +  G P          W+   A  C  
Sbjct: 631  EGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSA--CSP 688

Query: 645  CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
             VS     PC    Q +     AC V+  T    APC   + P  YF+ C  DAC+  G 
Sbjct: 689  LVSGSPLDPCDVHLQAASYSVQACSVL--TGEMFAPCSAFLSPVPYFEQCRRDACRC-GQ 745

Query: 705  PGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764
            P  LC  +A Y   C+  G  +    R   C L C A   Y  C   C  +C  L++PE 
Sbjct: 746  P-CLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEA 804

Query: 765  C---------ESACREGCVC--DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPG--- 810
            C            C EGC C  D       D CVP  QC C   G  YP G+   P    
Sbjct: 805  CGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGH 864

Query: 811  -------PECERRCECG--PGGHV-----------------TCQE--------------- 829
                     C+ R      P G V                 TC++               
Sbjct: 865  CHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLS 924

Query: 830  -----------GAACGPHEECRL----------EDGVQACHATGCGR------------- 855
                       G AC   EEC            +  +  CH   C R             
Sbjct: 925  GCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAST 984

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEK---NAAGDLQRLLV 912
            C A G  HY T DG  +D  G+C   L +       D  FS+++E     ++G + R   
Sbjct: 985  CTAYGDRHYRTFDGLPFDFVGACKVHLVK----STSDVSFSVIVENVNCYSSGMICR--- 1037

Query: 913  TVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGR-------NMVLQTTKGLRLLFD 965
                + +S+  G  + V  +    P     +    E          +V    + + LL+D
Sbjct: 1038 ----KFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWD 1093

Query: 966  GDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCG 1025
                + +     ++G+L GLCGNF+    ++   P     ++ + FG++W    ++  C 
Sbjct: 1094 QRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSW----AAVECP 1149

Query: 1026 EGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDL--CAQ 1083
            +   P+   +C+        + + C  L +    F  C  V+  + ++  C+ D   C+Q
Sbjct: 1150 DTLDPR--DMCVLNPLREPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCSQ 1205

Query: 1084 KGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121
             GD    C S++AY   C   GVAV  WRT   CP  C
Sbjct: 1206 GGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCPYDC 1242



 Score =  254 bits (649), Expect = 4e-67
 Identities = 233/821 (28%), Positives = 317/821 (38%), Gaps = 90/821 (10%)

Query: 440  GGSLVCTPASCGLGEVCGLLPSGQ--HGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCE 497
            GG  V  PA C         P  Q  +   P   + C+AWG  H  T DG  +   G   
Sbjct: 116  GGECV-HPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGS 174

Query: 498  YLLSAPCHGPPLGAENFTVTVANEHR-GSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD 556
            Y L    H P    ++F++ V N+ + GS   + +R+V+L              +++   
Sbjct: 175  YTLVGR-HEPE--GQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQ---EIHLAKEVTHG 228

Query: 557  GVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNY 616
            G+ V LP  + S     L+G  V+V   S  +LA+DG S V +++         GLCGN 
Sbjct: 229  GMRVQLPHVMGSARLQQLAGY-VIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN 287

Query: 617  NQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCT------PEQQESFGGPDACGV 670
            N DP DDL    GK     V       E      P P T      P  Q++ G     GV
Sbjct: 288  NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQ--GV 345

Query: 671  ISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQL 726
                +  L P    CH  V P  +   C  D CQ  G     C A+A Y  AC  AG  L
Sbjct: 346  YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPL 405

Query: 727  GEWRRP-DFCPLQCPAHSH-YELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGD 784
              WR     C + C   +  Y  C   CP SC   ++    E AC +GC C  G +    
Sbjct: 406  QGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDG 465

Query: 785  TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDG 844
             CV   +C C   G  YP      PG   +  C                     C    G
Sbjct: 466  GCVAPAECPCEFHGTLYP------PGSVVKEDCNT-------------------CTCTSG 500

Query: 845  VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 903
               C    C   C   G IH+ T DGR Y    +C Y+LA+          F++ L+   
Sbjct: 501  KWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAK----SRSSGTFTVTLQNAP 556

Query: 904  AG---------DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL 954
             G          +  +L     + V+L Q   V +  +   +P             ++ L
Sbjct: 557  CGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFL 616

Query: 955  Q--TTKGLRLLFDGDA-HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETF 1011
            +  T  G+R+L+D +   L + +   +     GLCG FNGN  DDF+ P G   S+ + F
Sbjct: 617  RVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLF 676

Query: 1012 GAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSE 1071
            G +W+   +      G     C V L  + A Y S +AC  L      FA C A LSP  
Sbjct: 677  GNSWKTLSACSPLVSGSPLDPCDVHL--QAASY-SVQACSVLTGEM--FAPCSAFLSPVP 731

Query: 1072 YFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICT 1131
            YF QC  D C  +  +  LC +LA Y   C+  G+ V        C L C A   YS C 
Sbjct: 732  YFEQCRRDAC--RCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCV 789

Query: 1132 RTCQGSCAALSGLTGC---------TTRCFEGCEC-DDRFLLSQG-VCIPVQDCGCTHNG 1180
              C  +C  L+    C            C EGC C  D +L +Q  +C+P   C C   G
Sbjct: 790  APCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQG 849

Query: 1181 RYLPVNSSLLTSDCSERCSCSS---SSGLTCQAAGCPPGRV 1218
               P   S + S     C C     S      AA CP G+V
Sbjct: 850  VDYPPGDSDIPS--LGHCHCKDGVMSCDSRAPAAACPAGQV 888



 Score =  161 bits (407), Expect = 5e-39
 Identities = 154/588 (26%), Positives = 227/588 (38%), Gaps = 47/588 (7%)

Query: 816  RCECGPGGHVTCQEGAACGPHE--ECRLEDGV----QACHATGCGR---CLANGGIHYIT 866
            R +C P    +C  G  C      +CR  +      Q  +  G  R   C A G  H  T
Sbjct: 102  RAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVET 161

Query: 867  LDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-------LVTVAGQVV 919
             DG  Y L G  SY L  V   +P  + FSI +  +               L  V  Q +
Sbjct: 162  FDGLYYYLSGKGSYTL--VGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEI 219

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFR 979
             LA+  +VT  G  V LP  +G  R+      ++++      L +DG + + + +     
Sbjct: 220  HLAK--EVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELL 277

Query: 980  GRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAE 1039
            G   GLCGN N +  DD V  +G     V  F  +W+    ++  G        P CL +
Sbjct: 278  GWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQ 337

Query: 1040 ETAPYES-NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYT 1098
                 +   E C  L  P  PF  C A +SP  +   C  DLC   GD A  CR+LA Y 
Sbjct: 338  NPGTMQGVYEQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYA 395

Query: 1099 AACQAAGVAVKPWRTD-SFCPLHCPAHSH-YSICTRTCQGSCAALSGLTGCTTRCFEGCE 1156
             AC  AG  ++ WRT    C +HC   +  Y+ C   C  SC   +        C +GC 
Sbjct: 396  RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCY 455

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
            C +  +   G C+   +C C  +G   P   S++  DC+  C+C+S     C  A CP  
Sbjct: 456  CPNGLIFEDGGCVAPAECPCEFHGTLYP-PGSVVKEDCN-TCTCTSGK-WECSTAVCP-- 510

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYR 1276
                  AE          C ++   + TTFDG R    +   Y L+        T+    
Sbjct: 511  ------AE----------CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQN 554

Query: 1277 VVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDG 1336
                +       ++V  +        VTLT    V +      +P     +  + R    
Sbjct: 555  APCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV 614

Query: 1337 SLLVRQKAGVQVWLGANG-KVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
             L VR   GV+V     G ++ + V         G CG F+G+  +D+
Sbjct: 615  FLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDF 662



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 118/502 (23%), Positives = 190/502 (37%), Gaps = 87/502 (17%)

Query: 755  SCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLH----DGRYYPLGEVFYPG 810
            S P+LS  EG   A       +     +  TCVP+ +  C+     +G+   + +  +  
Sbjct: 2025 SAPALSIVEGLAEALATTTEAN-----TSTTCVPIAEQDCVRHICLEGQLIRVNQSQHC- 2078

Query: 811  PECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGR 870
            P+      CG  G      G  C P  EC       AC      RC     + ++T DG 
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWEC-------AC------RCSIFPDLSFVTFDGS 2125

Query: 871  VYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRL-----------LVTVAGQVV 919
               L     Y+L+Q       DE  ++ +    + +L  L           +  +A QV 
Sbjct: 2126 HVALFKEAIYILSQ-----SPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVT 2180

Query: 920  SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLM---SIPS 976
                 ++VTVD + V  PV+    R+   G   ++ T   +++ +   + L++   S  S
Sbjct: 2181 IDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTS 2240

Query: 977  PFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVET---FGAAWRVPGSSKGCGE------G 1027
              +G   GLCG  +G+ ++D  L +GS     E    F  +W+VP S    G+       
Sbjct: 2241 KAQGH--GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDS 2298

Query: 1028 CGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            C    C  CL        +  AC +   P+   + C+  +  ++Y +Q            
Sbjct: 2299 CATTDCSPCL--RMVSNRTFSACHRFVPPE---SFCELWIRDTKYVQQP----------- 2342

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTG- 1146
               C +L  Y A C    V ++ WR   +CP  C + S Y  C   C+       G+ G 
Sbjct: 2343 ---CVALTVYVAMCHKFHVCIE-WRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGP 2398

Query: 1147 -----CTTRCFEGCECDDRFLLSQ---GVCIPVQDCGCTHN---GRYLPVNSSLLTSDCS 1195
                 C     EGC C +  +L +    +CIP   C CT +    R L    +   S C 
Sbjct: 2399 LDPEHCQV-LGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCC 2457

Query: 1196 ERCSCSSSSGLTCQAAGCPPGR 1217
            +   C +   +     GCP  R
Sbjct: 2458 QH-QCQAPDTIVPVDLGCPSPR 2478



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 105/415 (25%), Positives = 157/415 (37%), Gaps = 79/415 (19%)

Query: 447  PASCGLGEVCGL-LPSGQHGCQPV--STAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAP 503
            P  CG   + GL +  G   C P+      C  + D  +VT DG          Y+LS  
Sbjct: 2084 PPRCG---ILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS 2140

Query: 504  -----------CHGPPLGAEN---FTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSAR- 548
                       C    LG  N   F + + N             VT+  +N  +T+  + 
Sbjct: 2141 PDEMLTVHVLDCKSANLGHLNWPPFCLVMLN------MTHLAHQVTIDRFNRKVTVDLQP 2194

Query: 549  -WPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRL----RVPA 603
             WP   +         F+++   H ++      + T S + + +   S + +    +   
Sbjct: 2195 VWPPVSRYG-------FRIEDTGHMYM------ILTPSDIQIQWLHSSGLMIVEASKTSK 2241

Query: 604  AYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECV-SKPCPSPCTPEQQESF 662
            A    LCG+C     D A+DL    G      VGGA+     + S   PS  T   Q  F
Sbjct: 2242 AQGHGLCGICDG---DAANDLTLKDGSV----VGGAEDPAPFLDSWQVPSSLTSVGQTRF 2294

Query: 663  GGPDACGVISAT-------DGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
              PD+C     +       +   + CH  VPP  + +  + D   VQ      C A+  Y
Sbjct: 2295 R-PDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQP----CVALTVY 2349

Query: 716  VAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSC--PVSCP----SLSAPEGCESAC 769
            VA C      + EWRR D+CP  C + S Y+ C  +C  P +C         PE C+   
Sbjct: 2350 VAMCHKFHVCI-EWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQ-VL 2407

Query: 770  REGCVCDAGFVL---SGDTCVPVGQCGCLHD-GRYYPLGEVFYPGPE--CERRCE 818
             EGCVC  G +L       C+P  +C C    G    LGE +       C+ +C+
Sbjct: 2408 GEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQ 2462



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 77/315 (24%), Positives = 117/315 (37%), Gaps = 43/315 (13%)

Query: 46   PCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTG 105
            PCH   C       ++G     L    +TC  +GD HY +FDG  FDF G C   L    
Sbjct: 963  PCHTCVC-------QRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHL---- 1011

Query: 106  CLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTAL 165
               V +     F+V  +N N  +  +   + +++  +G ++ +  D+ G           
Sbjct: 1012 ---VKSTSDVSFSVIVENVNCYSSGMICRKFISI-NVGNSLIVFDDDSG--------NPS 1059

Query: 166  PVSVADGRISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDR 222
            P S  D +  V         +  F    + + +D    V V     + G + GLCGN D 
Sbjct: 1060 PESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 223  NPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSC---PTCPEDRLEQYEGPGF 279
               N+   P      +   +G SW A         EC  +      C  + L +      
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAV--------ECPDTLDPRDMCVLNPLREPFAKKE 1171

Query: 280  CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV--CMGGGDHDILCKALASYVAACQAAGV 337
            C  L       F  CH  V    F+  C+ D   C  GGD +  C ++++Y   C   GV
Sbjct: 1172 CSILLSEV---FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGV 1228

Query: 338  VIEDWRAQVGCEITC 352
             + DWR    C   C
Sbjct: 1229 AV-DWRTPRLCPYDC 1242



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 112/432 (25%), Positives = 157/432 (36%), Gaps = 65/432 (15%)

Query: 67   CLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNE 124
            C P +E  C   ++ D  + +FDG          Y+L+ +       + LT   +  K+ 
Sbjct: 2101 CCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS-----PDEMLTVHVLDCKSA 2155

Query: 125  NRGN---PAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            N G+   P    V ++ +  L   ++I +    KV V+      PVS    RI       
Sbjct: 2156 NLGHLNWPPFCLV-MLNMTHLAHQVTIDRFN-RKVTVDLQPVWPPVSRYGFRIEDTGHMY 2213

Query: 182  KALLVADFGLQVSYDWNWR-VDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTL----- 235
              L  +D  +Q  +      V+ +  S   G   GLCG  D +  ND    +G++     
Sbjct: 2214 MILTPSDIQIQWLHSSGLMIVEASKTSKAQGH--GLCGICDGDAANDLTLKDGSVVGGAE 2271

Query: 236  --APSIPIWG--GSWRAPGWDPLCWDECRGS-CPTCPEDRLEQYEGPGFCGPLAPGTGGP 290
              AP +  W    S  + G      D C  + C  C                L   +   
Sbjct: 2272 DPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPC----------------LRMVSNRT 2315

Query: 291  FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI 350
            F+ CH  VPPESF +  + D           C AL  YVA C    V IE WR    C  
Sbjct: 2316 FSACHRFVPPESFCELWIRDTKYVQQP----CVALTVYVAMCHKFHVCIE-WRRSDYCPF 2370

Query: 351  TCPENSHYEVCGPPC--PASCPSP--APLTTPAVCEGPCVEGCQCDAGFVL---SADRCV 403
             C  +S Y+ C   C  P +C      PL  P  C+    EGC C  G +L    +  C+
Sbjct: 2371 LCSSDSTYQACVTACEPPKTCQDGILGPL-DPEHCQ-VLGEGCVCSEGTILHRRHSALCI 2428

Query: 404  PLNNGCGCWANGTYHEAGSEFW---ADGTCSQWCRCGP-----GGGSLVCTPASC-GLGE 454
            P    C C  +     A  E W     G C   C+          G     P SC   GE
Sbjct: 2429 P-EAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGE 2487

Query: 455  VCGLLPSGQHGC 466
            V  LLP+    C
Sbjct: 2488 VALLLPTKDPCC 2499



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)

Query: 1121 CPAHSHYSICT-----------RTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCI 1169
            CPA   +  C+           RTC+     LS        C  GC C    L     C 
Sbjct: 883  CPAGQVFVNCSDLHTDLELSRERTCEQQLLNLS--VSARGPCLSGCACPQGLLRHGDACF 940

Query: 1170 PVQDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSS 1204
              ++C CT  G+ Y P     + S C   C C   S
Sbjct: 941  LPEECPCTWKGKEYFP--GDQVMSPC-HTCVCQRGS 973


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score =  281 bits (719), Expect = 3e-75
 Identities = 309/1235 (25%), Positives = 442/1235 (35%), Gaps = 223/1235 (18%)

Query: 75   CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
            C  WG  H+ +FD   +DF GTCNY+ A T            F+V    + R  P  S  
Sbjct: 45   CSTWGAGHFSTFDHHVYDFSGTCNYIFAAT-----CKDAFPTFSV----QLRRGPDGSIS 95

Query: 135  RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVS 194
            R++    LG ++    + I  V+  GV++ LP + ++G      G S  L+     L++ 
Sbjct: 96   RIIV--ELGASVVTVSEAIISVKDIGVIS-LPYT-SNGLQITPFGQSVRLVAKQLELELE 151

Query: 195  YDW--NWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGT-LAPSIPIWGGSWRAPGW 251
              W  +  + V +   Y G +CGLCGN D    N+ V   G  L P           PG 
Sbjct: 152  VVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPG- 210

Query: 252  DPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV 311
              +C      +    P   + Q +    C  L              V  E F   C  DV
Sbjct: 211  -EIC------TFQDIPSTHVRQAQHARICTQLLT-----LVAPECSVSKEPFVLSCQADV 258

Query: 312  CMGG--GDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI-TCPENSHYEVCGPPCPAS 368
                  G  +  C  L+ Y   C   G  +  WR+   C +  CP N  Y+ CG  C  +
Sbjct: 259  AAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKT 318

Query: 369  CPSPAPLTTPAVCEGPCVEGCQCDAGFVLSA----DRCVPLNNGCGCWANGTYHEAGSEF 424
            C +P        C   C  GC C  G VL+       CVP+   C C  +G  +  G   
Sbjct: 319  CSNPQHS-----CSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQ-CPCVLHGAMYAPGEVT 372

Query: 425  WADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVT 484
             A     Q CRC  G    VCT   C                       C   G     T
Sbjct: 373  IA---ACQTCRCTLG--RWVCTERPC--------------------PGHCSLEGGSFVTT 407

Query: 485  LDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLT 544
             D   + F GTC Y+L      P L  +   + V ++   S + +   +V        + 
Sbjct: 408  FDARPYRFHGTCTYIL---LQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIV 464

Query: 545  LSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAA 604
            +S      +  +G    LP++  ++     +   + + T+ GL L        +  V   
Sbjct: 465  ISQ--DEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVG 522

Query: 605  --YAASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPC 654
              +     GLCGN+N D  DD     G   G        W+ G      E  +     PC
Sbjct: 523  PQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGNCPAALERET----DPC 578

Query: 655  TPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVAT 714
            +  Q         C ++  T      CH  V PA +++ C+  AC  +     +C A+  
Sbjct: 579  SMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGD 638

Query: 715  YVAACQAAGAQLGEWRRP-DFCPLQCPAHSHYELCGDSCPVSCPSLS--APEGCESACR- 770
            YV AC   G  L  WR   D C + C  ++ +     +C  +C SLS  A E   SA   
Sbjct: 639  YVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPV 698

Query: 771  EGCVC-DAGFVLSGDTCVPVGQCGCLHDGRYYPL----------------GEVFYP---- 809
            +GC C D  ++     CV   QC C+ +G  + L                G +  P    
Sbjct: 699  DGCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQ 758

Query: 810  -----------------------GPECERRCE------------CGPGGHVTCQEG---- 830
                                   G  C   C+            C PG    C EG    
Sbjct: 759  MFLASCQAPKTFKSCSQSSENKFGAACAPTCQMLATGVACVPTKCEPG--CVCAEGLYEN 816

Query: 831  --AACGPHEECRLE-DGVQ---------ACHATGCGR--------------CLANGGIHY 864
                C P EEC  E  GV           C    C R              C   G  H 
Sbjct: 817  ADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHV 876

Query: 865  ITLDGRVYDLHGSCSYVLA-QVCHPKPGDEDFSIVLEK----NAAGDLQRLLVTVAGQVV 919
            IT DG+ +   G+C Y+LA  VC        F I+ E     N+     R +    G + 
Sbjct: 877  ITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLS 936

Query: 920  SLAQGQQVTVDGEA--VALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSP 977
             +   +  TV GE   V L V  G + +  +   + +     L L+++    +L+ I   
Sbjct: 937  VVLADRNYTVTGEEPHVQLGVTPGALSLVVD---ISIPGRYNLTLIWNRHMTILIRIARA 993

Query: 978  FRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCL 1037
             +  LCGLCGNFNGN  DDF   +   ASS      +W+    S  CG+         C 
Sbjct: 994  SQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWK---ESPLCGDVSFV--TDPCS 1048

Query: 1038 AEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLA 1095
                    +   C  + +    FATC + +    Y+  CV D C     GD   LC ++A
Sbjct: 1049 LNAFRRSWAERKCSVINSQ--TFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVA 1106

Query: 1096 AYTAACQAAGVAVKPWRTDSFCPLHCPAHS--------------------HYSICTRTCQ 1135
            AY  AC   GV V  WRT +FCP++C  ++                    HY  C    Q
Sbjct: 1107 AYAQACLDKGVCV-DWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQ 1165

Query: 1136 GSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIP 1170
                  S + GC       C  D+ F   +GVC+P
Sbjct: 1166 PQSVPGSNIEGC-----YNCSQDEYFDHEEGVCVP 1195



 Score =  261 bits (668), Expect = 3e-69
 Identities = 257/1054 (24%), Positives = 403/1054 (38%), Gaps = 195/1054 (18%)

Query: 473  ECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 532
            +C  WG  H+ T D H +DF GTC Y+ +A C         F+V +     GS +     
Sbjct: 44   QCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKD---AFPTFSVQLRRGPDGSIS----- 95

Query: 533  SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSL--A 590
             + +++    +T+S        + GV ++LP+  + L       +  +V     L L   
Sbjct: 96   RIIVELGASVVTVSEAIISVKDI-GV-ISLPYTSNGLQITPFGQSVRLVAKQLELELEVV 153

Query: 591  FDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGA----QGCGE-C 645
            +  DS + + V   Y   +CGLCGN++    ++  +  GK        A       GE C
Sbjct: 154  WGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPGEIC 213

Query: 646  VSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLD--ACQVQG 703
              +  PS    + Q +      C  +     P       V    +   C  D  A    G
Sbjct: 214  TFQDIPSTHVRQAQHA----RICTQLLTLVAPECS----VSKEPFVLSCQADVAAAPQPG 265

Query: 704  HPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPL-QCPAHSHYELCGDSCPVSCPSLSAP 762
                 C  ++ Y   C   G  +  WR P  C + QCPA+  Y+ CG +C  +C +    
Sbjct: 266  PQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSN--PQ 323

Query: 763  EGCESACREGCVCDAGFVLS----GDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCE 818
              C S+C  GC C  G VL+      TCVPV QC C+  G  Y  GEV            
Sbjct: 324  HSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTI---------- 373

Query: 819  CGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHYITLDGRVYDLHGS 877
                        AAC   + CR   G   C    C G C   GG    T D R Y  HG+
Sbjct: 374  ------------AAC---QTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGT 418

Query: 878  CSYVLAQVCHPK-PGDEDFSIVLEKNAAGDLQRLLVTVA----GQVVSLAQGQQVTVDGE 932
            C+Y+L Q   P+ P D     V +K+     +  LV V        + ++Q + VT +GE
Sbjct: 419  CTYILLQ--SPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGE 476

Query: 933  AVALPVAVGRVRVTAE-GRNMVLQTTKGLRLLFDGDA--HLLMSIPSPFRGRLCGLCGNF 989
            A  LP     + V  +   ++ + T+ GL L+          +++   FRG+  GLCGNF
Sbjct: 477  AKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNF 536

Query: 990  NGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEA 1049
            NG+ +DDF    G A  +   F  +WR                CP  L  ET P   ++ 
Sbjct: 537  NGDTTDDFTTSMGIAEGTASLFVDSWRAGN-------------CPAALERETDPCSMSQL 583

Query: 1050 --------CGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAAC 1101
                    C  L      F  C A ++P+ ++++CVY  C  +     +C +L  Y  AC
Sbjct: 584  NKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHAC 643

Query: 1102 QAAGVAVKPWRTD-SFCPLHCPAHSHYSICTRTCQGSCAALSG-LTGC--TTRCFEGCEC 1157
               GV +  WR+    C + C  ++ +S  ++ C+ +C +LS   T C  +    +GC C
Sbjct: 644  SLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNC 703

Query: 1158 DDRFLLSQ-GVCIPVQDCGCTHNG-RYLPVNSSLLTSDCSERC----------------- 1198
             D   L+Q G C+    C C   G +++    S + +  +  C                 
Sbjct: 704  PDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLAS 763

Query: 1199 --------SCSSSS-----------------GLTCQAAGCPPGRVC-------------- 1219
                    SCS SS                 G+ C    C PG VC              
Sbjct: 764  CQAPKTFKSCSQSSENKFGAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVP 823

Query: 1220 -----------------EVKAEARNCWATRG------------LCVLSVGANLTTFDGAR 1250
                             E+  + R C  +RG             C L    ++ TFDG R
Sbjct: 824  PEECPCEFSGVSYPGGAELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQR 883

Query: 1251 GATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKG 1310
                    Y L++   G+ ++ P ++++ E  IC        +    F  G+  +  ++ 
Sbjct: 884  FVFDGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRN 943

Query: 1311 VWVNGLRVDLPAEKLASV--SVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKL 1368
              V G   + P  +L     ++S   D S+  R    + +W   +  + + ++      L
Sbjct: 944  YTVTG---EEPHVQLGVTPGALSLVVDISIPGRYNLTL-IW-NRHMTILIRIARASQDPL 998

Query: 1369 CGACGNFDGDQTNDWHD------SQEKPAMEKWR 1396
            CG CGNF+G+  +D+        S E   +  W+
Sbjct: 999  CGLCGNFNGNMKDDFETRSRYVASSELELVNSWK 1032



 Score =  187 bits (475), Expect = 6e-47
 Identities = 217/861 (25%), Positives = 316/861 (36%), Gaps = 158/861 (18%)

Query: 50   VTCRPQETCKEQGGQGVCLPN-YEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLG 108
            VT    +TC+   G+ VC        C L G     +FD R + F GTC Y+L  +  L 
Sbjct: 371  VTIAACQTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLP 430

Query: 109  VSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVS 168
                 +  +  +  + +      S V VV ++     I I +DE+  V  NG    LP  
Sbjct: 431  EDGALMAVYDKSGVSHSE----TSLVAVVYLSRQD-KIVISQDEV--VTNNGEAKWLPYK 483

Query: 169  VADGRISVAQGASKALLVA-DFGLQVSYDWN--WRVDVTLPSSYHGAVCGLCGNMDRNPN 225
              +  I+V +  S  L +A  FGL++       ++  VT+   + G   GLCGN + +  
Sbjct: 484  TRN--ITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTT 541

Query: 226  NDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPT--------CPEDRLEQYEGP 277
            +D     G    +  ++  SWRA            G+CP         C   +L +    
Sbjct: 542  DDFTTSMGIAEGTASLFVDSWRA------------GNCPAALERETDPCSMSQLNKVCAE 589

Query: 278  GFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGV 337
              C  L   TG  F  CHA V P  F+K CV   C        +C AL  YV AC   GV
Sbjct: 590  THCSMLLR-TGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGV 648

Query: 338  VIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFV 396
            ++  WR+ V  C I C  N+ +      C  +C S +   T        V+GC C  G  
Sbjct: 649  LLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTY 708

Query: 397  LS----------------------ADRCVPLN-------NG------------CGCWANG 415
            L+                      A++   +N       NG              C A  
Sbjct: 709  LNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPK 768

Query: 416  TYHEA--GSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVC--GLLPSGQHGCQPVST 471
            T+      SE      C+  C+    G  + C P  C  G VC  GL  +    C P   
Sbjct: 769  TFKSCSQSSENKFGAACAPTCQMLATG--VACVPTKCEPGCVCAEGLYENADGQCVPPEE 826

Query: 472  AECQ---------------------------------------AWGDPHYVTLDGHRFDF 492
              C+                                        +G+ H +T DG RF F
Sbjct: 827  CPCEFSGVSYPGGAELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVF 886

Query: 493  QGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRK 552
             G CEY+L+    G       F +   N   G+  V+ +R++ + +   S+ L+    R 
Sbjct: 887  DGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLA---DRN 943

Query: 553  LQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGL 612
              V G    +  QL     A     D+ +     L+L ++    + +R+  A    LCGL
Sbjct: 944  YTVTGEEPHV--QLGVTPGALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGL 1001

Query: 613  CGNYNQDPADDLKAVGGKPAGWQVGGAQG------CGECVSKPCPSPCTPEQQESFGGPD 666
            CGN+N +  DD +      A  ++           CG+        PC+           
Sbjct: 1002 CGNFNGNMKDDFETRSRYVASSELELVNSWKESPLCGDV--SFVTDPCSLNAFRRSWAER 1059

Query: 667  ACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQ--GHPGGLCPAVATYVAACQAAGA 724
             C VI++     A CH  V    Y++ C+ DAC     G    LC AVA Y  AC   G 
Sbjct: 1060 KCSVINSQ--TFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGV 1117

Query: 725  QLGEWRRPDFCPLQC--------PAHSHYELCGD-SC-----PVSCPSLSAPEGCESACR 770
             + +WR P FCP+ C          H  Y+   + +C     P  CP  S P+    +  
Sbjct: 1118 CV-DWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCP--SQPQSVPGSNI 1174

Query: 771  EGCV-C--DAGFVLSGDTCVP 788
            EGC  C  D  F      CVP
Sbjct: 1175 EGCYNCSQDEYFDHEEGVCVP 1195



 Score =  170 bits (431), Expect = 8e-42
 Identities = 157/578 (27%), Positives = 248/578 (42%), Gaps = 64/578 (11%)

Query: 840  RLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVL 899
            RL+D  Q   A   G+C   G  H+ T D  VYD  G+C+Y+ A  C  K     FS+ L
Sbjct: 31   RLKDSPQT--APDKGQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATC--KDAFPTFSVQL 86

Query: 900  EKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVL---QT 956
             +   G + R++V +   VV++++      D   ++LP     +++T  G+++ L   Q 
Sbjct: 87   RRGPDGSISRIIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQL 146

Query: 957  TKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWR 1016
               L +++  D+HL++ +   + G++CGLCGNF+G  +++FV   G        F A  +
Sbjct: 147  ELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEP-HKFAALQK 205

Query: 1017 VPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQC 1076
            +       GE C  Q  P   +      +    C QL     P    +  +S   +   C
Sbjct: 206  LDDP----GEICTFQDIP---STHVRQAQHARICTQLLTLVAP----ECSVSKEPFVLSC 254

Query: 1077 VYDLCA--QKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPL-HCPAHSHYSICTRT 1133
              D+ A  Q G +   C +L+ Y+  C   G  V+ WR+   C +  CPA+  Y  C   
Sbjct: 255  QADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSA 314

Query: 1134 CQGSCAALSGLTGCTTRCFEGCECDDRFLL----SQGVCIPVQDCGCT-HNGRYLPVNSS 1188
            C  +C+  +    C++ C  GC C +  +L    +   C+PV  C C  H   Y P   +
Sbjct: 315  CVKTCS--NPQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVT 372

Query: 1189 LLTSDCSERCSCSSSSGLTCQAAGCPPGR-VCEVKAEARNCWATRGLCVLSVGANLTTFD 1247
            +                  CQ   C  GR VC      R C    G C L  G+ +TTFD
Sbjct: 373  I----------------AACQTCRCTLGRWVC----TERPC---PGHCSLEGGSFVTTFD 409

Query: 1248 GARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTP 1307
                       Y L  + P L        V  +  + H +T  V  V++  QD +V ++ 
Sbjct: 410  ARPYRFHGTCTYIL-LQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIV-ISQ 467

Query: 1308 NKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQ--VWLGANGKVAVIVSNDHA 1365
            ++ V  NG    LP  K  +++V R     L +    G++  V L    +  V V     
Sbjct: 468  DEVVTNNGEAKWLP-YKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFR 526

Query: 1366 GKLCGACGNFDGDQTNDWHDSQ---EKPA---MEKWRA 1397
            G+  G CGNF+GD T+D+  S    E  A   ++ WRA
Sbjct: 527  GQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRA 564


>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
          Length = 1503

 Score =  208 bits (529), Expect = 3e-53
 Identities = 184/560 (32%), Positives = 237/560 (42%), Gaps = 85/560 (15%)

Query: 657  EQQESFG-GPDACGVISATDGPLAP----CHGLVPPAQYFQGCLLDACQVQGHPGGLCPA 711
            E  ESF  G D C V      P  P    CH    P+    GC        G P   CP 
Sbjct: 962  EPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPS--LVGCPPSQLLPPG-PQHCCPT 1018

Query: 712  VATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELC-GDSCP-VSCPSL---SAPEGCE 766
             A  ++ C + G    E   PD C   C       LC   +CP +SCP     + P  C 
Sbjct: 1019 CAEALSNC-SEGLLGSELAPPDPC-YTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCC 1076

Query: 767  SACR---EGCVCDAGFVLSG-----DTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCE 818
              CR   + CV     V SG     DTC     C C+        G V      C+ +  
Sbjct: 1077 PVCRAPTQSCVHQGREVASGERWTVDTCT---SCSCM-------AGTV-----RCQSQ-R 1120

Query: 819  CGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCL-------ANGGIHYITLDGRV 871
            C P          +CGP +   L  G  +C    C RCL       A G  HY T DGR+
Sbjct: 1121 CSP---------LSCGPDKAPALSPG--SC----CPRCLPRPASCMAFGDPHYRTFDGRL 1165

Query: 872  YDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGD-----LQRLLVTVAGQVVSLAQGQQ 926
                GSCSYVLA+ CH      DFS+ +  +  G       Q + V +    V L Q   
Sbjct: 1166 LHFQGSCSYVLAKDCH----SGDFSVHVTNDDRGRSGVAWTQEVAVLLGDMAVRLLQDGA 1221

Query: 927  VTVDGEAVALP-VAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGL 985
            VTVDG  VALP +    + V   G  ++L    GL++L+DG + + +S+P  ++GR CGL
Sbjct: 1222 VTVDGHPVALPFLQEPLLYVELRGHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGL 1281

Query: 986  CGNFNGNWSDDFVLPNGSAASSVETFGAAWRV-PGSSKGCGEGCGPQGCPVCLAEETAPY 1044
            CGNFNG   DD   P G    S   FG +W+V  G   G     G +  P   A   A  
Sbjct: 1282 CGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSEGLWPGRPCSAGREVDPCRAAGYRARR 1341

Query: 1045 ESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA---QKGDKAFLCRSLAAYTAAC 1101
            E+N  CG L++   PF+ C AV+ P  +F  CVYDLCA        A LC +L AY + C
Sbjct: 1342 EANARCGVLKS--SPFSRCHAVVPPEPFFAACVYDLCACGPGSSADACLCDALEAYASHC 1399

Query: 1102 QAAGVAVKPWRTDSFCPLHCPAHSHYSI------CTRTCQGSCAALSGLTG-CTTRCFEG 1154
            + AGV    WR  + C + CP    +        C RTC      L  L   C   C  G
Sbjct: 1400 RQAGV-TPTWRGPTLCVVGCPLERGFVFDECGPPCPRTCFNQHIPLGELAAHCVRPCVPG 1458

Query: 1155 CECDDRFLLSQGVCIPVQDC 1174
            C+C    +  +  CIP + C
Sbjct: 1459 CQCPAGLVEHEAHCIPPEAC 1478



 Score =  195 bits (495), Expect = 3e-49
 Identities = 132/369 (35%), Positives = 174/369 (47%), Gaps = 26/369 (7%)

Query: 47   CHGVTCRPQETCKEQGGQGV--CLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATT 104
            C  ++C P +      G     CLP   A+C  +GDPHY +FDGR   FQG+C+YVLA  
Sbjct: 1121 CSPLSCGPDKAPALSPGSCCPRCLPR-PASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKD 1179

Query: 105  GCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTA 164
               G        F+V   N++RG   V++ + V V      + + +D  G V V+G   A
Sbjct: 1180 CHSG-------DFSVHVTNDDRGRSGVAWTQEVAVLLGDMAVRLLQD--GAVTVDGHPVA 1230

Query: 165  LPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNP 224
            LP  + +  + V       +L A  GLQV +D   +V+V++P SY G  CGLCGN +   
Sbjct: 1231 LPF-LQEPLLYVELRGHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFA 1289

Query: 225  NNDQVFPNGTLAPSIPIWGGSWRAPG--WDPLCWDECRGSCPTCPEDRLEQYEGPGFCGP 282
             +D   P G L PS   +G SW+     W        R   P        + E    CG 
Sbjct: 1290 QDDLQGPEGLLLPSEAAFGNSWQVSEGLWPGRPCSAGREVDPCRAAGYRARREANARCGV 1349

Query: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDVCM---GGGDHDILCKALASYVAACQAAGVVI 339
            L      PF+ CHA VPPE FF  CV D+C    G      LC AL +Y + C+ AGV  
Sbjct: 1350 L---KSSPFSRCHAVVPPEPFFAACVYDLCACGPGSSADACLCDALEAYASHCRQAGVT- 1405

Query: 340  EDWRAQVGCEITCP--ENSHYEVCGPPCPASC-PSPAPL-TTPAVCEGPCVEGCQCDAGF 395
              WR    C + CP      ++ CGPPCP +C     PL    A C  PCV GCQC AG 
Sbjct: 1406 PTWRGPTLCVVGCPLERGFVFDECGPPCPRTCFNQHIPLGELAAHCVRPCVPGCQCPAGL 1465

Query: 396  VLSADRCVP 404
            V     C+P
Sbjct: 1466 VEHEAHCIP 1474



 Score =  194 bits (494), Expect = 4e-49
 Identities = 169/577 (29%), Positives = 235/577 (40%), Gaps = 86/577 (14%)

Query: 258  ECRGSCPTCPEDRLEQYEGPGF-----------CGPLAPGTGGPFTTCHAHVPPESFFKG 306
            +C   C  C  +  +   G  F           C P   G   P   CH    P     G
Sbjct: 946  DCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGP--PSLRCHRRQCPS--LVG 1001

Query: 307  CVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCP 366
            C     +  G     C   A  ++ C + G++  +      C     ++  +      CP
Sbjct: 1002 CPPSQLLPPGPQHC-CPTCAEALSNC-SEGLLGSELAPPDPCYTCQCQDLTWLCIHQACP 1059

Query: 367  A-SCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFW 425
              SCP     T P    G C   C+      +   R V                A  E W
Sbjct: 1060 ELSCPLSERHTPP----GSCCPVCRAPTQSCVHQGREV----------------ASGERW 1099

Query: 426  ADGTCSQWCRCGPGG---GSLVCTPASCGLGEVCGLLP-SGQHGCQPVSTAECQAWGDPH 481
               TC+  C C  G     S  C+P SCG  +   L P S    C P   A C A+GDPH
Sbjct: 1100 TVDTCTS-CSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLP-RPASCMAFGDPH 1157

Query: 482  YVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNH 541
            Y T DG    FQG+C Y+L+  CH     + +F+V V N+ RG   V++T+ V + + + 
Sbjct: 1158 YRTFDGRLLHFQGSCSYVLAKDCH-----SGDFSVHVTNDDRGRSGVAWTQEVAVLLGDM 1212

Query: 542  SLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRV 601
            ++ L       + VDG  VALPF  + LL+  L G  V++    GL + +DG S V + V
Sbjct: 1213 AVRLLQ--DGAVTVDGHPVALPFLQEPLLYVELRGHTVILHAQPGLQVLWDGQSQVEVSV 1270

Query: 602  PAAYAASLCGLCGNYNQDPADDLKAVGG--KPA------GWQVGGAQGCGECVSKPCPS- 652
            P +Y    CGLCGN+N    DDL+   G   P+       WQV      G    +PC + 
Sbjct: 1271 PGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSE----GLWPGRPCSAG 1326

Query: 653  ----PCTPEQQESFGGPDA-CGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGG 707
                PC      +    +A CGV+ ++  P + CH +VPP  +F  C+ D C     PG 
Sbjct: 1327 REVDPCRAAGYRARREANARCGVLKSS--PFSRCHAVVPPEPFFAACVYDLCAC--GPGS 1382

Query: 708  -----LCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSH--YELCGDSCPVSCPSLS 760
                 LC A+  Y + C+ AG     WR P  C + CP      ++ CG  CP +C +  
Sbjct: 1383 SADACLCDALEAYASHCRQAGV-TPTWRGPTLCVVGCPLERGFVFDECGPPCPRTCFNQH 1441

Query: 761  APEG-----CESACREGCVCDAGFVLSGDTCVPVGQC 792
             P G     C   C  GC C AG V     C+P   C
Sbjct: 1442 IPLGELAAHCVRPCVPGCQCPAGLVEHEAHCIPPEAC 1478



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 57/229 (24%), Positives = 85/229 (37%), Gaps = 21/229 (9%)

Query: 1166 GVCIPVQDC---GCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVK 1222
            G C PV       C H GR +          C+  CSC + + + CQ+  C P      K
Sbjct: 1073 GSCCPVCRAPTQSCVHQGREVASGERWTVDTCTS-CSCMAGT-VRCQSQRCSPLSCGPDK 1130

Query: 1223 AEARN-------CWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWY 1275
            A A +       C      C+     +  TFDG          Y L+  C     ++   
Sbjct: 1131 APALSPGSCCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGDFSVH-- 1188

Query: 1276 RVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLP--AEKLASVSVSRT 1333
              V              +V +   D  V L  +  V V+G  V LP   E L  V +   
Sbjct: 1189 --VTNDDRGRSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELR-- 1244

Query: 1334 PDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTND 1382
               ++++  + G+QV      +V V V   + G+ CG CGNF+G   +D
Sbjct: 1245 -GHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDD 1292



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 67/243 (27%), Positives = 82/243 (33%), Gaps = 46/243 (18%)

Query: 640  QGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDAC 699
            +G   C  KPCP    P       GP  C V          CH  +   +  Q    D  
Sbjct: 806  EGSMRCQKKPCPPALCPHPSP---GPCFCPV----------CHSCLSQGREHQ----DGE 848

Query: 700  QVQGHPGGLCP-------AVATYVAACQAAGAQLGEWRRPDFCPL--QCPAHSHYELCGD 750
            + +G P G C         V+     C     +L    R   CP    C AH      G 
Sbjct: 849  EFEG-PAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGS 907

Query: 751  SC---PVSCPSLSAPEGCESACREGCVCDAGFVLSGD-TCVPVGQCG-CLHDGRYYPLGE 805
                   +C S    EG  +  R  C+        G   C P  QC  C H+GR Y  GE
Sbjct: 908  RWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCP--QCSDCEHEGRKYEPGE 965

Query: 806  VFYPGPE-CE-RRCECGPGGHVT-------CQEGAACGPHEECRLEDGVQACHATGCGRC 856
             F PG + CE   CE  P G  +       C     C P +   L  G Q C  T C   
Sbjct: 966  SFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQ--LLPPGPQHCCPT-CAEA 1022

Query: 857  LAN 859
            L+N
Sbjct: 1023 LSN 1025



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 69/258 (26%), Positives = 85/258 (32%), Gaps = 54/258 (20%)

Query: 214 CGLCGNMDRNPNNDQVFPNGTLAPSIPI-WGGSWR------APGWDPL-----CWDECRG 261
           C  C    +   + + FP+ T A  + + W GS        AP   P      C  +C G
Sbjct: 659 CDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDG 718

Query: 262 SCPTCPEDRLEQYEGPGFCGP--LAPGTGGPFTTCHAHV--PPESFFKGCVLDVCMGGGD 317
            C    E  L   E P    P  L    GG F TC      PP     GC   +   G  
Sbjct: 719 -CEYLGESYLSNQEFPDPREPCNLCTCLGG-FVTCGRRPCEPP-----GCSHPLIPSG-- 769

Query: 318 HDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTT 377
           H         Y     A+G  + D         TC E S      P  PA CP P+P   
Sbjct: 770 HCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSP--- 826

Query: 378 PAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCG 437
                GPC                C   ++   C + G  H+ G EF       +WCRC 
Sbjct: 827 -----GPCF---------------CPVCHS---CLSQGREHQDGEEFEGPAGSCEWCRCQ 863

Query: 438 PGGGSLV---CTPASCGL 452
            G  S V   C P  C L
Sbjct: 864 AGQVSCVRLQCPPLPCKL 881



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 38/124 (30%), Positives = 46/124 (37%), Gaps = 31/124 (25%)

Query: 351 TCPENSHYEVCGPP---CPASCPSPAP-------LTTPAVCEGPCVEGCQCDAGFVLSAD 400
           +C E +  E C PP   CP  C             TTP     PC   C+C  G +    
Sbjct: 172 SCSELNCLESCTPPGECCPICCTEGGSHWEHGQEWTTPG---DPC-RICRCLEGHIQCRQ 227

Query: 401 R-CV--------PLNNGC-----GCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCT 446
           R C         PL   C     GC+ NG  H +G    +   CS  CRC    GS+ C 
Sbjct: 228 RECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSH-CRC--ANGSVQCE 284

Query: 447 PASC 450
           P  C
Sbjct: 285 PLPC 288



 Score = 37.7 bits (86), Expect = 0.078
 Identities = 65/243 (26%), Positives = 82/243 (33%), Gaps = 62/243 (25%)

Query: 641 GCGECVSKPCPSPCTPEQQ-----ESFGGP-DACGVISATDG---------PLAPCHGLV 685
           G G+C  + CP  C  E++     ESF  P D C      +G         P APC   +
Sbjct: 473 GPGQCCPR-CPD-CILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL 530

Query: 686 PPAQYFQGCLLDACQVQGHPGGLC---PAVATYVAACQAAGAQLGEWRRPDFCPLQCPAH 742
           P       C   A   + +P G     P+    +  C +   Q    R     PL CP  
Sbjct: 531 PGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARR---CVPLPCP-- 585

Query: 743 SHYELCGDSCPVSCPSLSAPEGCE-----------------SACREGCVCDAGFVLSGDT 785
               L G+ CP  CP   AP GC                    CR  C+C  G V     
Sbjct: 586 EPVLLPGECCP-QCP---APAGCPRPGAAHARHQEYFSPPGDPCRR-CLCLDGSVSCQRL 640

Query: 786 CVPVGQC-------------GCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAA 832
             P   C             GCL+ G+ +  GE F         C C  G  V+C E  A
Sbjct: 641 PCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGS-VSC-EPKA 698

Query: 833 CGP 835
           C P
Sbjct: 699 CAP 701



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 34/108 (31%), Positives = 42/108 (38%), Gaps = 16/108 (14%)

Query: 762 PEGCE---SACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCE 818
           PEG      AC   CVC  G    G         GC  +G+ Y  GE F   P+    C 
Sbjct: 104 PEGARWEPDACT-ACVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGETF--SPDACTTCR 160

Query: 819 CGPGGHVTCQEGAACGPHEECRLEDGVQACHATG--CGRCLANGGIHY 864
           C  G  V CQ     GP   C   + +++C   G  C  C   GG H+
Sbjct: 161 CLTGA-VQCQ-----GP--SCSELNCLESCTPPGECCPICCTEGGSHW 200



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 118/496 (23%), Positives = 154/496 (31%), Gaps = 95/496 (19%)

Query: 389 CQCDAGFVLSADRCVP---LNNGCGCWANGTYHEAGSEFWADGTCSQWCRC--------G 437
           C C  G    A  C P   L +  GC  NG  +  G  F  D   +  CRC        G
Sbjct: 117 CVCQDG----AAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTT--CRCLTGAVQCQG 170

Query: 438 PGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVT--LDGHRFDFQGT 495
           P    L C  +    GE C +  + + G       E    GDP  +   L+GH    Q  
Sbjct: 171 PSCSELNCLESCTPPGECCPICCT-EGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE 229

Query: 496 CEYLLSAPCHGPP---LGAENFTVTVANEHRGSQAV------SYTRSVTLQIYNHSLT-- 544
           C  L   P    P       +       EHR  + V      S+ R     +    L   
Sbjct: 230 CASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCP 289

Query: 545 -LSARWPRKLQ------VDGV-FVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 596
            +  R P K+        DG  +    +Q          G  V  +  +G     + +  
Sbjct: 290 PVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECP 349

Query: 597 VRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTP 656
           V    P A  AS   LC     D  +  + V  +P G      + C  CV +        
Sbjct: 350 V---TPCALPASGRQLCPACELDGEEFAEGVQWEPDG------RPCTACVCQD------- 393

Query: 657 EQQESFGGPDACGVISATDGPLAPC-HGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATY 715
                  G   CG +     P APC H   PP      C  D+C                
Sbjct: 394 -------GVPKCGAVLC---PPAPCQHPTQPPGACCPSC--DSCTYHSQVYANGQNFTDA 441

Query: 716 VAACQAAGAQLGE------------WRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAP- 762
            + C A   Q G               RP   P QC       +  +   V   S S P 
Sbjct: 442 DSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPR 501

Query: 763 EGC-ESACREGCV---------CDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVF-YPGP 811
           + C E  C+EG                 L G TC P    GC   G+ YP G  F +P  
Sbjct: 502 DPCQECRCQEGHAHCQPRPCPRAPCAHPLPG-TCCPNDCSGCAFGGKEYPSGADFPHPSD 560

Query: 812 ECERRCECGPGGHVTC 827
            C R C C   G+V C
Sbjct: 561 PC-RLCRC-LSGNVQC 574



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 11/87 (12%)

Query: 366 PASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCG--CWANGTYHEAGSE 423
           P +C +   LT    C+GP      C        + C P    C   C   G++ E G E
Sbjct: 153 PDACTTCRCLTGAVQCQGPSCSELNC-------LESCTPPGECCPICCTEGGSHWEHGQE 205

Query: 424 FWADGTCSQWCRCGPGGGSLVCTPASC 450
           +   G   + CRC    G + C    C
Sbjct: 206 WTTPGDPCRICRCLE--GHIQCRQREC 230


>gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]
          Length = 2639

 Score =  205 bits (521), Expect = 3e-52
 Identities = 181/720 (25%), Positives = 278/720 (38%), Gaps = 144/720 (20%)

Query: 611  GLCGNYNQDPADDLKAVGGKPAGWQVGGA---QGCGECVSKP--CPSPCTPEQQESFGGP 665
            GLCGN+N    DD K   G       G A   +    C  K      PC+   + +    
Sbjct: 427  GLCGNFNGLEGDDFKTASGLVEATGAGFANTWKAQSSCHDKLDWLDDPCSLNIESANYAE 486

Query: 666  DACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQ 725
              C ++  T+ P   CH  V PA+Y++ C  D C  Q +   LC A+++Y  AC A G  
Sbjct: 487  HWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGVM 546

Query: 726  LGEWRRPDFCPL---QCPAHSHYELCGDSCPVSCPSLSAPEGCESACRE------GCVC- 775
            L  WR    C      CP    +     +C  +C SLS     +S C E      GC C 
Sbjct: 547  LWGWRE-HVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSE---ADSHCLEGFAPVDGCGCP 602

Query: 776  DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPG------------- 822
            D  F+     CVP+ +C C H G Y   G+V       E RC C  G             
Sbjct: 603  DHTFLDEKGRCVPLAKCSCYHRGLYLEAGDVVV---RQEERCVCRDGRLHCRQIRLIGQS 659

Query: 823  ---------------------GHVTCQEGAACGPHEEC---------RLEDGVQAC---- 848
                                   ++CQ  AA   H EC          ++DG   C    
Sbjct: 660  CTAPKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPDGLMDDGRGGCVVEK 719

Query: 849  ----------HATG------CGRCLANGGI------------------HYITLDGRVYDL 874
                      +++G      C  C    G                   HYIT DG+ YD 
Sbjct: 720  ECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDF 779

Query: 875  HGSCSYVLAQ-VCHPKPGDEDFSIVLEKNAAGDL-----QRLLVTVAGQVVSLAQGQQVT 928
             G CSYV  Q  C        FSI+ E    G       + + + +    + L    +V 
Sbjct: 780  DGHCSYVAVQDYCGQNSSLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVV 839

Query: 929  V---DGEAVALPVAVGRVRVTAE-GRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCG 984
            +   +G  VA          T E G+ +V++++ G+ +++D    + + +   ++G +CG
Sbjct: 840  IQRDEGHHVAY--------TTREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYKGTVCG 891

Query: 985  LCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPY 1044
            LCGNF+   ++DF   +    SS   FG +W+   +         P     C        
Sbjct: 892  LCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTCPDVSTNPEP-----CSLNPHRRS 946

Query: 1045 ESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTAACQ 1102
             + + C  L++    F+ C + + P  ++  CV+D C+    GD    C ++A+Y   C 
Sbjct: 947  WAEKQCSILKS--SVFSICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQECT 1004

Query: 1103 AAGVAVKPWRTDSFCPLHC----PAHS---HYSICTRTCQGSCAALSGL-TGCTTRCFEG 1154
              G  V  WRT   CP+ C    P H    HY  C      +C  ++G+ +  +    EG
Sbjct: 1005 KEGACVF-WRTPDLCPIFCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEG 1063

Query: 1155 C--EC-DDRFLLSQGV--CIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQ 1209
            C   C  DR +  + +  C+    CGC     + P  +S+ T +  + C C++SS + C+
Sbjct: 1064 CYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASVPTEETCKSCVCTNSSQVVCR 1123



 Score =  139 bits (350), Expect = 2e-32
 Identities = 121/484 (25%), Positives = 191/484 (39%), Gaps = 76/484 (15%)

Query: 385  CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLV 444
            CV GC C  G +        +   C C  N   + +G++   D  C+  C C  G    V
Sbjct: 697  CVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVD--CNT-CTCKRG--RWV 751

Query: 445  CTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPC 504
            CT A C             HG        C  +G  HY+T DG  +DF G C Y+     
Sbjct: 752  CTQAVC-------------HGT-------CSIYGSGHYITFDGKYYDFDGHCSYVAVQDY 791

Query: 505  HGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVD-GVFVALP 563
             G      +F++   N   G+  V+ ++++ + +    L L  +    +Q D G  VA  
Sbjct: 792  CGQNSSLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYT 851

Query: 564  FQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADD 623
                        G  +VV +++G+ + +D  + V +++  +Y  ++CGLCGN++    +D
Sbjct: 852  --------TREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNND 903

Query: 624  LKAVGGKPAGWQVGGAQGCGECVSKP----CPSPCTPEQQESFGGPDACGVISATDGPLA 679
                       ++       E  + P     P PC+            C ++ ++    +
Sbjct: 904  FTTRDHMVVSSELDFGNSWKEAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSS--VFS 961

Query: 680  PCHGLVPPAQYFQGCLLDACQVQ--GHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPL 737
             CH  V P  +++ C+ D+C     G     C AVA+Y   C   GA +  WR PD CP+
Sbjct: 962  ICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQECTKEGACV-FWRTPDLCPI 1020

Query: 738  QC----PAHS---HYELCGDSCPVSCP---------SLSAPEGCESAC-REGCVCDAGFV 780
             C    P H    HYE CG+    +C          S+S  EGC   C ++  + +    
Sbjct: 1021 FCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDL- 1079

Query: 781  LSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTC-----------QE 829
                 CV   +CGC  +  +YP G    P  E  + C C     V C           Q+
Sbjct: 1080 ---KKCVTADKCGCYVEDTHYPPG-ASVPTEETCKSCVCTNSSQVVCRPEEGKILNQTQD 1135

Query: 830  GAAC 833
            GA C
Sbjct: 1136 GAFC 1139



 Score =  133 bits (335), Expect = 1e-30
 Identities = 126/510 (24%), Positives = 193/510 (37%), Gaps = 114/510 (22%)

Query: 970  LLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCG 1029
            L +++    +G++ GLCGNFNG   DDF   +G   ++   F   W+   S   C +   
Sbjct: 413  LFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGLVEATGAGFANTWKAQSS---CHDKLD 469

Query: 1030 PQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAF 1089
                P  L  E+A Y +   C  L+  + PF  C + + P+EY+++C YD C  + ++  
Sbjct: 470  WLDDPCSLNIESANY-AEHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDC 528

Query: 1090 LCRSLAAYTAACQAAGVAVKPWRTDSFCPL---HCPAHSHYSICTRTCQGSCAALSGLTG 1146
            LC +L++Y  AC A GV +  WR +  C      CP    +     TCQ +C +LS    
Sbjct: 529  LCAALSSYARACTAKGVMLWGWR-EHVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSEADS 587

Query: 1147 CTTRCF---EGCECDDR-FLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSC-- 1200
                 F   +GC C D  FL  +G C+P+  C C H G YL     ++  +  ERC C  
Sbjct: 588  HCLEGFAPVDGCGCPDHTFLDEKGRCVPLAKCSCYHRGLYLEAGDVVVRQE--ERCVCRD 645

Query: 1201 --------------------------------SSSSGLTCQ--AAG-----CPPGRVC-- 1219
                                            S    L+CQ  AAG     C  G VC  
Sbjct: 646  GRLHCRQIRLIGQSCTAPKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPD 705

Query: 1220 -----------------------------EVKAEARNCWATRG--LCVLSVGANLTTFDG 1248
                                         ++K +   C   RG  +C  +V     +  G
Sbjct: 706  GLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYG 765

Query: 1249 ARGATTSPG-VYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQD---GMVT 1304
            +    T  G  Y+    C            VA    C G+  ++G   I  ++   G   
Sbjct: 766  SGHYITFDGKYYDFDGHC----------SYVAVQDYC-GQNSSLGSFSIITENVPCGTTG 814

Query: 1305 LTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGS-----------LLVRQKAGVQVWLGAN 1353
            +T +K + +   R +L  E    V + R                L+V    G+ V     
Sbjct: 815  VTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKR 874

Query: 1354 GKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
              V + ++  + G +CG CGNFD    ND+
Sbjct: 875  TTVFIKLAPSYKGTVCGLCGNFDHRSNNDF 904



 Score =  130 bits (326), Expect = 1e-29
 Identities = 114/406 (28%), Positives = 169/406 (41%), Gaps = 38/406 (9%)

Query: 57   TCKEQGGQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLT 115
            TC  + G+ VC       TC ++G  HY +FDG+ +DF G C+YV     C   S+ G  
Sbjct: 742  TCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLG-- 799

Query: 116  PFTVTTKNENRGNPAVSYVRVVTVAALGTNISIH-KDEIGKVRVNGVLTALPVSVADGRI 174
             F++ T+N   G   V+  + + +    T + +  K  +   R  G   A       G+ 
Sbjct: 800  SFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTREV-GQY 858

Query: 175  SVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGT 234
             V + ++        G+ V +D    V + L  SY G VCGLCGN D   NND    +  
Sbjct: 859  LVVESST--------GIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHM 910

Query: 235  LAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTC 294
            +  S   +G SW+     P C D      P C  +   +      C  L       F+ C
Sbjct: 911  VVSSELDFGNSWKEA---PTCPDVSTNPEP-CSLNPHRRSWAEKQCSILKSSV---FSIC 963

Query: 295  HAHVPPESFFKGCVLDVCM--GGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 352
            H+ V P+ F++ CV D C    GGD +  C A+ASY   C   G  +  WR    C I C
Sbjct: 964  HSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQECTKEGACV-FWRTPDLCPIFC 1022

Query: 353  PENS-------HYEVCGPPCPASCPSPAPL---TTPAVCEGPCVEGCQCDAG-FVLSADR 401
               +       HYE CG     +C +   +    + +  EG C   C  D   +     +
Sbjct: 1023 DYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEG-CYPRCPKDRPIYEEDLKK 1081

Query: 402  CVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTP 447
            CV  +  CGC+   T++  G+    + TC   C C      +VC P
Sbjct: 1082 CVTADK-CGCYVEDTHYPPGASVPTEETCKS-CVC-TNSSQVVCRP 1124



 Score =  127 bits (319), Expect = 8e-29
 Identities = 122/451 (27%), Positives = 172/451 (38%), Gaps = 56/451 (12%)

Query: 54   PQETCKEQGGQGVCLPNYEATCWLW---------GDPHYHSFDGRKFDFQGTCNYVLATT 104
            P  TC   G Q V + + +  CW W         GDPHY +FDG  + +QG C YVL   
Sbjct: 1912 PMPTCSN-GLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEE 1970

Query: 105  GCLGVSTQGLTPFTV-TTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLT 163
                V   G+         N+    P    VR  T   L   + +   ++ +V+VN    
Sbjct: 1971 ISPSVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMPMQV-QVQVNRQAV 2029

Query: 164  ALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYH---GAVCGLCGNM 220
            ALP     G      G +  + + + G+ VSY+      V LP  YH       G CG  
Sbjct: 2030 ALPYK-KYGLEVYQSGINYVVDIPELGVLVSYN-GLSFSVRLP--YHRFGNNTKGQCGTC 2085

Query: 221  DRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCP---TCPEDRLEQYEGP 277
                ++D + P+G +  +       W       L  D  +  CP   +  +       G 
Sbjct: 2086 TNTTSDDCILPSGEIVSNCEAAADQW-------LVNDPSKPHCPHSSSTTKRPAVTVPGG 2138

Query: 278  GFCGPLAPGTGGP---------FTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASY 328
            G   P    T  P         F  CHA VPP+ ++  CV D C   G   + C +L +Y
Sbjct: 2139 GKTTPHKDCTPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPGS-SLECASLQAY 2197

Query: 329  VAACQAAGVVIEDWRAQV--GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCV 386
             A C    + + DWR      C + CP +  Y+ CGP    +C S +      V     V
Sbjct: 2198 AALCAQQNICL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQNNTV----LV 2252

Query: 387  EGCQCDAG---FVLSADRCVPLNNGCGC-WANGTYHEAGSEFWADGTCSQWCRCGPGGGS 442
            EGC C  G   +    D CV     CGC   +    E G  F  D  C   C C  GG  
Sbjct: 2253 EGCFCPEGTMNYAPGFDVCV---KTCGCVGPDNVPREFGEHFEFD--CKN-CVCLEGGSG 2306

Query: 443  LVCTPASCGLGEVCGLLPSGQHGCQPVSTAE 473
            ++C P  C    V   +  G +    V+ A+
Sbjct: 2307 IICQPKRCSQKPVTHCVEDGTYLATEVNPAD 2337



 Score =  127 bits (318), Expect = 1e-28
 Identities = 114/425 (26%), Positives = 167/425 (39%), Gaps = 42/425 (9%)

Query: 816  RCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDL 874
            + EC P    TC  G      +  R+ED    C    C   C   G  HY+T DG  Y  
Sbjct: 1905 KVECEPPPMPTCSNGL-----QPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSY 1959

Query: 875  HGSCSYVLAQVCHPKPGDEDFSIVLEK-----NAAGDLQRLLV-------TVAGQVVSLA 922
             G+C+YVL +     P  ++F + ++      N      R L+        +   V  + 
Sbjct: 1960 QGNCTYVLVE--EISPSVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMP 2017

Query: 923  QGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTK-GLRLLFDGDAHLLMSIPSP---F 978
               QV V+ +AVALP     + V   G N V+   + G+ + ++G   L  S+  P   F
Sbjct: 2018 MQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDIPELGVLVSYNG---LSFSVRLPYHRF 2074

Query: 979  RGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSK-GCGEGCGPQGCPVCL 1037
                 G CG      SDD +LP+G   S+ E     W V   SK  C         P   
Sbjct: 2075 GNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVT 2134

Query: 1038 AE---ETAPYES---NEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLC 1091
                 +T P++    +  C  +++    FA C A++ P  Y+  CV+D C   G  +  C
Sbjct: 2135 VPGGGKTTPHKDCTPSPLCQLIKD--SLFAQCHALVPPQHYYDACVFDSCFMPG-SSLEC 2191

Query: 1092 RSLAAYTAACQAAGVAVKPWR--TDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT 1149
             SL AY A C    + +  WR  T   C + CP+H  Y  C    + +C + S      T
Sbjct: 2192 ASLQAYAALCAQQNICL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQN-NT 2249

Query: 1150 RCFEGCECDDRFL-LSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTC 1208
               EGC C +  +  + G  + V+ CGC                DC         SG+ C
Sbjct: 2250 VLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVPREFGEHFEFDCKNCVCLEGGSGIIC 2309

Query: 1209 QAAGC 1213
            Q   C
Sbjct: 2310 QPKRC 2314



 Score =  117 bits (294), Expect = 6e-26
 Identities = 119/428 (27%), Positives = 183/428 (42%), Gaps = 56/428 (13%)

Query: 459  LPSGQHGCQPVSTAE-------------CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCH 505
            +P+  +G QPV   +             C  WGDPHYVT DG  + +QG C Y+L     
Sbjct: 1913 MPTCSNGLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEIS 1972

Query: 506  GPPLGAENFTVTVANEH-RGSQAVSYTRSVTLQIYNHSLTLSA----RWPRKLQVDGVFV 560
                  +NF V + N H   +  VS  R++ ++     + +          ++QV+   V
Sbjct: 1973 P---SVDNFGVYIDNYHCDPNDKVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAV 2029

Query: 561  ALPFQLDSLLHAHLSGADVVVTTTS-GLSLAFDGDSFVRLRVP-AAYAASLCGLCGNYNQ 618
            ALP++    L  + SG + VV     G+ ++++G SF  +R+P   +  +  G CG    
Sbjct: 2030 ALPYKKYG-LEVYQSGINYVVDIPELGVLVSYNGLSF-SVRLPYHRFGNNTKGQCGTCTN 2087

Query: 619  DPADDLKAVGGK-PAGWQVGGAQGCGECVSKP-CPSPCTPEQQESF---GGPDACGVISA 673
              +DD     G+  +  +    Q      SKP CP   +  ++ +    GG         
Sbjct: 2088 TTSDDCILPSGEIVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDC 2147

Query: 674  TDGPL---------APCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGA 724
            T  PL         A CH LVPP  Y+  C+ D+C + G     C ++  Y A C     
Sbjct: 2148 TPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPG-SSLECASLQAYAALCAQQNI 2206

Query: 725  QLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG---F 779
             L +WR      C ++CP+H  Y+ CG +   +C S S+ +   +   EGC C  G   +
Sbjct: 2207 CL-DWRNHTHGACLVECPSHREYQACGPAEEPTCKSSSSQQN-NTVLVEGCFCPEGTMNY 2264

Query: 780  VLSGDTCVPVGQCGCL-HDGRYYPLGEVFYPGPECERRCECGPGGH-VTCQ-EGAACGPH 836
                D CV    CGC+  D      GE F    +C + C C  GG  + CQ +  +  P 
Sbjct: 2265 APGFDVCVKT--CGCVGPDNVPREFGEHF--EFDC-KNCVCLEGGSGIICQPKRCSQKPV 2319

Query: 837  EECRLEDG 844
              C +EDG
Sbjct: 2320 THC-VEDG 2326



 Score =  104 bits (259), Expect = 7e-22
 Identities = 84/319 (26%), Positives = 129/319 (40%), Gaps = 30/319 (9%)

Query: 474 CQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 533
           C  WG+ HY T DG  F F G C+Y  ++ C G     + F V +      ++A +   S
Sbjct: 37  CSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRG---SYKEFAVHLKRGPGQAEAPAGVES 93

Query: 534 VTLQIYNHSLTLSARWPRKLQV-DGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592
           + L I + ++ L+    R L V +G  V+ P     LL    S A   V + +GL+L ++
Sbjct: 94  ILLTIKDDTIYLT----RHLAVLNGAVVSTPHYSPGLL-IEKSDAYTKVYSRAGLTLMWN 148

Query: 593 GDSFVRLRVPAAYAASLCGLCGNYNQ-DPADDLKAVGGKPAGWQVGGAQG-------CGE 644
            +  + L +   +    CGLCG+YN      +  + G   +  + G  Q        C +
Sbjct: 149 REDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLFSPLEFGNMQKINQPDVVCED 208

Query: 645 CVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGH 704
              +  P+ C+  + E       C  +   +   A C  LVP   Y + C  D C+  G 
Sbjct: 209 PEEEVAPASCSEHRAE-------CERLLTAEA-FADCQDLVPLEPYLRACQQDRCRCPGG 260

Query: 705 PGGLCPAVATYVAACQAAGAQLGEWRRPDF-----CPLQCPAHSHYELCGDSCPVSCPSL 759
              +C  VA +   C  AG + G WR             CP +  Y   G  C  +C  L
Sbjct: 261 DTCVCSTVAEFSRQCSHAGGRPGNWRTATSAVSPGASKTCPGNLVYLESGSPCMDTCSHL 320

Query: 760 SAPEGCESACREGCVCDAG 778
                CE    +GC C  G
Sbjct: 321 EVSSLCEEHRMDGCFCPEG 339



 Score =  102 bits (254), Expect = 3e-21
 Identities = 109/392 (27%), Positives = 157/392 (40%), Gaps = 39/392 (9%)

Query: 136 VVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVA---DFGLQ 192
           VV +A    N+ + K + G V +N +   LP   A    SV + +S  ++V+      LQ
Sbjct: 348 VVLLADKKKNVVVFKSD-GSVLLNELQVNLPHVTAS--FSVFRPSSYHIMVSMAIGVRLQ 404

Query: 193 VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 252
           V      ++ VTL  +  G V GLCGN +    +D    +G +  +   +  +W+A    
Sbjct: 405 VQLAPVMQLFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGLVEATGAGFANTWKAQS-- 462

Query: 253 PLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVC 312
             C D+       C  +         +C  L   T  PF  CH+ V P  ++K C  D C
Sbjct: 463 -SCHDKLDWLDDPCSLNIESANYAEHWCS-LLKKTETPFGRCHSAVDPAEYYKRCKYDTC 520

Query: 313 MGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCEI---TCPENSHYEVCGPPCPASC 369
               + D LC AL+SY  AC A GV++  WR  V C     +CP +  +      C  +C
Sbjct: 521 NCQNNEDCLCAALSSYARACTAKGVMLWGWREHV-CNKDVGSCPNSQVFLYNLTTCQQTC 579

Query: 370 PSPAPLTTPAVCEGPCVEGCQC-DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADG 428
            S +   +  +     V+GC C D  F+    RCVPL   C C+  G Y EAG     D 
Sbjct: 580 RSLSEADSHCLEGFAPVDGCGCPDHTFLDEKGRCVPLAK-CSCYHRGLYLEAG-----DV 633

Query: 429 TCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVS--------TAECQAWGDP 480
              Q  RC    G L C      +G+ C   P     C  ++           CQ     
Sbjct: 634 VVRQEERCVCRDGRLHCRQIRL-IGQSC-TAPKIHMDCSNLTALATSKPRALSCQTLAAG 691

Query: 481 HY--------VTLDGHRFDFQGTCEYLLSAPC 504
           +Y        V  DG   D +G C      PC
Sbjct: 692 YYHTECVSGCVCPDGLMDDGRGGCVVEKECPC 723



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 28/317 (8%)

Query: 856  CLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKN-----AAGDLQRL 910
            C   G  HY T DG V+   G C Y  A  C  +   ++F++ L++      A   ++ +
Sbjct: 37   CSTWGNFHYKTFDGDVFRFPGLCDYNFASDC--RGSYKEFAVHLKRGPGQAEAPAGVESI 94

Query: 911  LVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL 970
            L+T+    + L +   V ++G  V+ P     + +        + +  GL L+++ +  L
Sbjct: 95   LLTIKDDTIYLTRHLAV-LNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLTLMWNREDAL 153

Query: 971  LMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGP 1030
            ++ + + FR   CGLCG++NG  S    L +G   S +E FG   ++      C +   P
Sbjct: 154  MLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLFSPLE-FGNMQKINQPDVVCED---P 209

Query: 1031 QGCPVCLAEETAPYESNE---ACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDK 1087
            +       EE AP   +E    C +L   +  FA CQ ++    Y R C  D C   G  
Sbjct: 210  E-------EEVAPASCSEHRAECERLLTAEA-FADCQDLVPLEPYLRACQQDRCRCPGGD 261

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSF-----CPLHCPAHSHYSICTRTCQGSCAALS 1142
              +C ++A ++  C  AG     WRT +          CP +  Y      C  +C+ L 
Sbjct: 262  TCVCSTVAEFSRQCSHAGGRPGNWRTATSAVSPGASKTCPGNLVYLESGSPCMDTCSHLE 321

Query: 1143 GLTGCTTRCFEGCECDD 1159
              + C     +GC C +
Sbjct: 322  VSSLCEEHRMDGCFCPE 338



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 84/328 (25%), Positives = 127/328 (38%), Gaps = 33/328 (10%)

Query: 75  CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYV 134
           C  WG+ HY +FDG  F F G C+Y  A + C G        F V  K       A + V
Sbjct: 37  CSTWGNFHYKTFDGDVFRFPGLCDYNFA-SDCRG----SYKEFAVHLKRGPGQAEAPAGV 91

Query: 135 RVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVA--DGRISVAQGASKALLVADFGLQ 192
             +        ++I  D I   R   VL    VS       + + +  +   + +  GL 
Sbjct: 92  ESIL-------LTIKDDTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLT 144

Query: 193 VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 252
           + ++    + + L + +    CGLCG+ +   +  +   +G L   +  +G   +    D
Sbjct: 145 LMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLFSPLE-FGNMQKINQPD 203

Query: 253 PLCWDECRGSCP-TCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV 311
            +C D      P +C E R E       C  L   T   F  C   VP E + + C  D 
Sbjct: 204 VVCEDPEEEVAPASCSEHRAE-------CERLL--TAEAFADCQDLVPLEPYLRACQQDR 254

Query: 312 CMGGGDHDILCKALASYVAACQAAGVVIEDWRAQV-----GCEITCPENSHYEVCGPPCP 366
           C   G    +C  +A +   C  AG    +WR        G   TCP N  Y   G PC 
Sbjct: 255 CRCPGGDTCVCSTVAEFSRQCSHAGGRPGNWRTATSAVSPGASKTCPGNLVYLESGSPCM 314

Query: 367 ASCPSPAPLTTPAVCEGPCVEGCQCDAG 394
            +C   + L   ++CE   ++GC C  G
Sbjct: 315 DTC---SHLEVSSLCEEHRMDGCFCPEG 339



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 30/92 (32%), Positives = 47/92 (51%), Gaps = 11/92 (11%)

Query: 1294 VHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGAN 1353
            V +F  DG V L        N L+V+LP    AS SV R     ++V    GV++ +   
Sbjct: 358  VVVFKSDGSVLL--------NELQVNLP-HVTASFSVFRPSSYHIMVSMAIGVRLQVQLA 408

Query: 1354 GKVAVIVSNDHA--GKLCGACGNFDGDQTNDW 1383
              + + V+ D A  G++ G CGNF+G + +D+
Sbjct: 409  PVMQLFVTLDQASQGQVQGLCGNFNGLEGDDF 440


>gi|37693519 BMP-binding endothelial regulator precursor protein
           [Homo sapiens]
          Length = 685

 Score =  185 bits (469), Expect = 3e-46
 Identities = 132/448 (29%), Positives = 191/448 (42%), Gaps = 43/448 (9%)

Query: 368 SCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRC---VPLNNGCGCWANGTYHEAGSEF 424
           +C +     +  VC+  C     CD G     + C   VP  +   C       + G E 
Sbjct: 255 NCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDIKVCKFGNKIFQDG-EM 313

Query: 425 WADGTCSQWCRCGPGGGSL---VCTP-ASCGLGEVCGLLPSGQHGCQPVSTAE---CQAW 477
           W+   C+  C C  G        C P +SC  G++       + GC P+ T +   C  +
Sbjct: 314 WSSINCTI-CACVKGRTECRNKQCIPISSCPQGKILN-----RKGCCPICTEKPGVCTVF 367

Query: 478 GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQ 537
           GDPHY T DG  F+FQGTC+Y+L+  C  P   A  F V V N+ R +++ S+T+SV L 
Sbjct: 368 GDPHYNTFDGRTFNFQGTCQYVLTKDCSSP---ASPFQVLVKNDARRTRSFSWTKSVELV 424

Query: 538 IYNHSLTL----SARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDG 593
           +    ++L    + RW      +G  +ALP +     H  L G  + VTT +GL +++DG
Sbjct: 425 LGESRVSLQQHLTVRW------NGSRIALPCRAPHF-HIDLDGYLLKVTTKAGLEISWDG 477

Query: 594 DSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGK--------PAGWQVGGAQGCGEC 645
           DSFV +         LCGLCGNYN    DDL    G            W+V   + C   
Sbjct: 478 DSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRP 537

Query: 646 VSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHP 705
             KP P  C    +        C  + + +     CH  V  A +++ C+ D C+   H 
Sbjct: 538 QRKPVPELCQGTVKVKLRAHRECQKLKSWE--FQTCHSTVDYATFYRSCVTDMCECPVHK 595

Query: 706 GGLCPAVATYVAACQAAGAQLGEWRRPDFCPL-QCPAHSHYELCGDSCPVSCPSLSAPEG 764
              C +   Y  ACQ  G ++  W     C   QC   + Y+ CG  C  +C + +    
Sbjct: 596 NCYCESFLAYTRACQREGIKV-HWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIGP 654

Query: 765 CESACREGCVCDAGFVLSGDTCVPVGQC 792
           C   C  GC C A  VL    C+    C
Sbjct: 655 CNKPCVAGCHCPANLVLHKGRCIKPVLC 682



 Score =  157 bits (396), Expect = 9e-38
 Identities = 109/364 (29%), Positives = 163/364 (44%), Gaps = 24/364 (6%)

Query: 47  CHGVTCRPQETC---KEQGGQGVC--LPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVL 101
           C    C P  +C   K    +G C         C ++GDPHY++FDGR F+FQGTC YVL
Sbjct: 331 CRNKQCIPISSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVL 390

Query: 102 ATTGCLGVSTQGLTPFTVTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGV 161
            T  C    +   +PF V  KN+ R   + S+ + V +    + +S+ +     VR NG 
Sbjct: 391 -TKDC----SSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLT--VRWNGS 443

Query: 162 LTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMD 221
             ALP       I +     K    A  GL++S+D +  V+V       G +CGLCGN +
Sbjct: 444 RIALPCRAPHFHIDLDGYLLKVTTKA--GLEISWDGDSFVEVMAAPHLKGKLCGLCGNYN 501

Query: 222 RNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLE-QYEGPGFC 280
            +  +D +  +G     +  +  SWR    +  C    R   P   +  ++ +      C
Sbjct: 502 GHKRDDLIGGDGNFKFDVDDFAESWRVES-NEFCNRPQRKPVPELCQGTVKVKLRAHREC 560

Query: 281 GPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIE 340
             L       F TCH+ V   +F++ CV D+C      +  C++  +Y  ACQ  G+ + 
Sbjct: 561 QKLK---SWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVH 617

Query: 341 DWRAQVGCEIT-CPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSA 399
            W  Q  C  T C   + Y+ CGP C  +C +   +     C  PCV GC C A  VL  
Sbjct: 618 -WEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEI---GPCNKPCVAGCHCPANLVLHK 673

Query: 400 DRCV 403
            RC+
Sbjct: 674 GRCI 677



 Score =  155 bits (391), Expect = 3e-37
 Identities = 125/440 (28%), Positives = 186/440 (42%), Gaps = 41/440 (9%)

Query: 748  CGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVF 807
            C DS  V     S P GC+   +EGC C+   +      + V    C    + +  GE+ 
Sbjct: 261  CRDSTVVCKRKCSHPGGCDQG-QEGC-CEECLLRVPPEDIKV----CKFGNKIFQDGEM- 313

Query: 808  YPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC--------GRCLAN 859
            +    C   C C  G    C+    C P   C      +  +  GC        G C   
Sbjct: 314  WSSINCTI-CACVKG-RTECRN-KQCIPISSCPQG---KILNRKGCCPICTEKPGVCTVF 367

Query: 860  GGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVV 919
            G  HY T DGR ++  G+C YVL + C           VL KN A   +    T + ++V
Sbjct: 368  GDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQ---VLVKNDARRTRSFSWTKSVELV 424

Query: 920  ------SLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMS 973
                  SL Q   V  +G  +ALP       +  +G  + + T  GL + +DGD+ + + 
Sbjct: 425  LGESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKAGLEISWDGDSFVEVM 484

Query: 974  IPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGC 1033
                 +G+LCGLCGN+NG+  DD +  +G+    V+ F  +WRV  S++ C     PQ  
Sbjct: 485  AAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVE-SNEFCNR---PQRK 540

Query: 1034 PV---CLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFL 1090
            PV   C         ++  C +L++ +  F TC + +  + ++R CV D+C     K   
Sbjct: 541  PVPELCQGTVKVKLRAHRECQKLKSWE--FQTCHSTVDYATFYRSCVTDMCECPVHKNCY 598

Query: 1091 CRSLAAYTAACQAAGVAVKPWRTDSFC-PLHCPAHSHYSICTRTCQGSCAALSGLTGCTT 1149
            C S  AYT ACQ  G+ V  W     C    C   + Y  C   C  +C   + +  C  
Sbjct: 599  CESFLAYTRACQREGIKVH-WEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNK 657

Query: 1150 RCFEGCECDDRFLLSQGVCI 1169
             C  GC C    +L +G CI
Sbjct: 658  PCVAGCHCPANLVLHKGRCI 677



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 60/268 (22%), Positives = 96/268 (35%), Gaps = 25/268 (9%)

Query: 1121 CPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNG 1180
            C       +C R C        G  GC   C               + +P +D      G
Sbjct: 259  CTCRDSTVVCKRKCSHPGGCDQGQEGCCEECL--------------LRVPPEDIKVCKFG 304

Query: 1181 RYLPVNSSLLTSDCSERCSC----SSSSGLTC-QAAGCPPGRVCEVKAEARNCWATRGLC 1235
              +  +  + +S     C+C    +      C   + CP G++   K     C    G+C
Sbjct: 305  NKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICTEKPGVC 364

Query: 1236 VLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH 1295
             +    +  TFDG          Y L+  C    +  P+  +V               V 
Sbjct: 365  TVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPAS--PFQVLVKNDARRTRSFSWTKSVE 422

Query: 1296 IFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLL-VRQKAGVQVWLGANG 1354
            +   +  V+L  +  V  NG R+ LP     +       DG LL V  KAG+++    + 
Sbjct: 423  LVLGESRVSLQQHLTVRWNGSRIALPCR---APHFHIDLDGYLLKVTTKAGLEISWDGDS 479

Query: 1355 KVAVIVSNDHAGKLCGACGNFDGDQTND 1382
             V V+ +    GKLCG CGN++G + +D
Sbjct: 480  FVEVMAAPHLKGKLCGLCGNYNGHKRDD 507



 Score = 31.6 bits (70), Expect = 5.6
 Identities = 32/94 (34%), Positives = 40/94 (42%), Gaps = 22/94 (23%)

Query: 384 PCVEGCQCDAGFVL-SADRCV-----PLNN------GC-GCWANGTYHEAGSEFWADGTC 430
           PCV   QC  G V  S  RCV     PL +       C GC   G  ++ G EF  +G  
Sbjct: 127 PCVLR-QCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEG-- 183

Query: 431 SQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQH 464
           S+  +C   GG   C      + EVC +L   QH
Sbjct: 184 SKCTKCSCTGGRTQC------VREVCPILSCPQH 211



 Score = 31.6 bits (70), Expect = 5.6
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 11/68 (16%)

Query: 769 CREGCVCDAGF---VLSGDTCVPVGQC-----GCLHDGRYYPLGEVFYP-GPECERRCEC 819
           C+EG V ++G    V   +    +G C     GC+ +G  Y  GE F P G +C  +C C
Sbjct: 133 CQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKC-TKCSC 191

Query: 820 GPGGHVTC 827
             GG   C
Sbjct: 192 -TGGRTQC 198


>gi|239750277 PREDICTED: hypothetical protein XP_002347351 [Homo
            sapiens]
          Length = 2134

 Score =  144 bits (363), Expect = 6e-34
 Identities = 139/532 (26%), Positives = 207/532 (38%), Gaps = 89/532 (16%)

Query: 769  CREGCVCDAGFVL-SGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTC 827
            C+ GC C  G V  S   CV    C C   GR Y  G V   G  C    EC      TC
Sbjct: 1253 CKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVG--CN---EC------TC 1301

Query: 828  QEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSY-VLAQVC 886
             +G+      EC+       CH  G G        H  T DG+ Y   G C Y  L   C
Sbjct: 1302 IKGSWSCTQNECQT-----ICHIYGEG--------HVRTFDGKSYSFDGLCQYSFLEDYC 1348

Query: 887  HPKPGDEDFSIVLE-----KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDG-EAVALPVAV 940
              + G   F I+ E     ++     ++++V    Q + L  G+   V   E+    +  
Sbjct: 1349 GHENGT--FRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTESKKCELNA 1406

Query: 941  GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLP 1000
                +   G  ++L+   G+ +++D +  L + +   + G++CGLCGN NG+  DDF   
Sbjct: 1407 NAYSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTR 1466

Query: 1001 NGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESN--------EACGQ 1052
              S AS    FG +W+   +S+ C +             +T P +SN          C  
Sbjct: 1467 YSSVASGALEFGNSWK---TSQECSD----------TVAQTFPCDSNPYCKAWAVRKCEI 1513

Query: 1053 LRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
            LR+    F  C   + PS Y   C+ + CA   +G     C ++A Y  AC A GV V  
Sbjct: 1514 LRD--STFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVCVS- 1570

Query: 1111 WRTDSFCPLHCPAHS-------HYSIC----TRTCQGSCAA---LSGLTGCTTRCFEGCE 1156
            WR  + CP++C  ++       HY  C     +TC+         S L GC  +C +   
Sbjct: 1571 WRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEGCYAKCPDSAP 1630

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
              D   +    C+ + +C C +N   +P    ++  +C   C C +   L C     P  
Sbjct: 1631 YLDENTMK---CVSLSECSCFYND-VIPA-GGVIEDNCGRTCYCIAGQ-LECSET-APTN 1683

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTS-PGVYELSSRCPG 1267
                V         T    +LS GA +T   G      S P +   SS   G
Sbjct: 1684 STFAVS-------TTTATTILSTGAAITLVTGGPSTAASIPAITTSSSETTG 1728



 Score =  135 bits (340), Expect = 3e-31
 Identities = 153/599 (25%), Positives = 222/599 (37%), Gaps = 102/599 (17%)

Query: 261  GSCPTCPEDRLEQYE-GPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHD 319
            G CP       E  E G   C  +    G  F  C       + +K   +D      D  
Sbjct: 669  GDCPNAVGKSYEVCEDGIQHCNKII---GTYFEKCGKVAALSNDYKMICIDEYCQTRDKT 725

Query: 320  ILCKALASYVAACQAAGV-VIEDWRAQ--VGCEIT-CPENSHYEVCGPPCPASCPSPAPL 375
              C   +     C + G    E WR+   V CE   CPE   Y+ CGP  PA+C + AP 
Sbjct: 726  STCDTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYKECGPSNPATCSNVAPF 785

Query: 376  TTPAVCEGPCVEGCQCDAGFVLS----ADRCVPLNNGCGCWANGTYHEAGSEFWADGTCS 431
                  +  CV GC C  G++L       +CV L   C C ++GT ++ G     +G C 
Sbjct: 786  Q-----DSECVSGCTCPEGYLLDDIGEKGKCV-LKAECPCESSGTVYQPGEV--REGPCG 837

Query: 432  QWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFD 491
              C C     S  CT A C                       C+  G     T DG +++
Sbjct: 838  SQCTCQDAKWS--CTEALC--------------------PGRCKVEGSS-LTTFDGVKYN 874

Query: 492  FQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGS-QAVSYTRSVTL----------QIYN 540
            F G C +L         +  E+++++V      S Q  +   SVTL           ++N
Sbjct: 875  FPGNCHFLA--------VHNEDWSISVELRPCPSGQTGTCLNSVTLLLNSSVPVDKYVFN 926

Query: 541  HSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLR 600
               T++     K++  G + +   Q+ +   ++L      V T   + L       ++L 
Sbjct: 927  SDGTVTND---KIRNQGYYYSDKIQIFNASSSYLQ-----VETYFHVKLQIQIVPVMQLY 978

Query: 601  V--PAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSKPC 650
            V  P        GLCG+YN    DD         K        W++     C     K  
Sbjct: 979  VSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEM---MSC----PKGN 1031

Query: 651  PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCP 710
            PS C   ++E F     CG++  + GPLA CH +V P  Y + C    C  +     LC 
Sbjct: 1032 PSSCISIEKEKFAERH-CGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQDCLCT 1090

Query: 711  AVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPE---GCES 767
             +  YV AC      +  W R   C   CP+   ++    +C  SC SLS  +     E 
Sbjct: 1091 ILGNYVKACAEKETYIVGW-RTGLCEHSCPSGLVFKYNVKACNSSCRSLSERDRSCDVED 1149

Query: 768  ACREGCVC-DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPEC---ERRCECGPG 822
               +GC C DA +  +   CV   QC C      Y   EV  PG      + +C C  G
Sbjct: 1150 VPVDGCTCPDAMYQNNEGNCVLKSQCDC------YINDEVMQPGKLIHIDDNKCVCRDG 1202



 Score =  127 bits (319), Expect = 8e-29
 Identities = 124/482 (25%), Positives = 191/482 (39%), Gaps = 87/482 (18%)

Query: 384  PCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSL 443
            PC  GC C  G V ++       N C C   G  ++ GS       C++ C C  G  S 
Sbjct: 1252 PCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSV--TSVGCNE-CTCIKGSWS- 1307

Query: 444  VCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEY-LLSA 502
             CT                Q+ CQ +    C  +G+ H  T DG  + F G C+Y  L  
Sbjct: 1308 -CT----------------QNECQTI----CHIYGEGHVRTFDGKSYSFDGLCQYSFLED 1346

Query: 503  PCHGPPLGAENFTVTVANEHRG--SQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFV 560
             C     G EN T  +  E        ++ +R + +   + ++ L          DG   
Sbjct: 1347 YC-----GHENGTFRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQ---------DGKVT 1392

Query: 561  ALPF------QLDSLLHA-HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLC 613
            A+        +L++  ++ H  G  +++   +G+ + +D ++ + + +   +   +CGLC
Sbjct: 1393 AVKSTESKKCELNANAYSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLC 1452

Query: 614  GNYNQDPADDLK------AVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDA 667
            GN N D  DD        A G    G     +Q C + V++    PC             
Sbjct: 1453 GNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQ--TFPCDSNPYCKAWAVRK 1510

Query: 668  CGVISATDGPLAPCHGLVPPAQYFQGCLLD--ACQVQGHPGGLCPAVATYVAACQAAGAQ 725
            C ++   D     CH  V P+ Y   C+ +  AC ++G   G C AVA Y  AC A G  
Sbjct: 1511 CEIL--RDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVC 1568

Query: 726  LGEWRRPDFCPLQCPAHS-------HYELCGDSCPVSCPS-------LSAPEGCESACRE 771
            +  WR+P+ CP+ C  ++       HYE CG     +C          S  EGC + C  
Sbjct: 1569 V-SWRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEGCYAKCP- 1626

Query: 772  GCVCDAGFVLSGDT--CVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQE 829
                D+   L  +T  CV + +C C ++    P G V      C R C C   G + C E
Sbjct: 1627 ----DSAPYLDENTMKCVSLSECSCFYND-VIPAGGVI--EDNCGRTCYC-IAGQLECSE 1678

Query: 830  GA 831
             A
Sbjct: 1679 TA 1680



 Score =  127 bits (318), Expect = 1e-28
 Identities = 131/545 (24%), Positives = 194/545 (35%), Gaps = 80/545 (14%)

Query: 694  CLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD---FCPLQ-CPAHSHYELCG 749
            C+ + CQ +      C   +     C + G    E  R D    C  Q CP    Y+ CG
Sbjct: 714  CIDEYCQTRDKTS-TCDTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYKECG 772

Query: 750  DSCPVSCPSLSAPEGCESACREGCVCDAGFVLSG----DTCVPVGQCGCLHDGRYYPLGE 805
             S P +C +++  +  +S C  GC C  G++L        CV   +C C   G  Y  GE
Sbjct: 773  PSNPATCSNVAPFQ--DSECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGE 830

Query: 806  VFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHY 864
            V        R   CG                 +C  +D   +C    C GRC   G    
Sbjct: 831  V--------REGPCG----------------SQCTCQDAKWSCTEALCPGRCKVEGS-SL 865

Query: 865  ITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQG 924
             T DG  Y+  G+C ++          +ED+SI +E       Q          V+L   
Sbjct: 866  TTFDGVKYNFPGNCHFLAVH-------NEDWSISVELRPCPSGQ---TGTCLNSVTLLLN 915

Query: 925  QQVTVDGEAVALPVAVGRVRVTAEG------------RNMVLQTTK----GLRLLFDGDA 968
              V VD         V   ++  +G             +  LQ        L++      
Sbjct: 916  SSVPVDKYVFNSDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQIQIVPVM 975

Query: 969  HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGC 1028
             L +S+P        GLCG++N    DDF+        + + F  +W +    KG     
Sbjct: 976  QLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMSCPKG----- 1030

Query: 1029 GPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKA 1088
             P  C     E+ A       CG L +  GP A+C  +++P  Y  +C    C  +  + 
Sbjct: 1031 NPSSCISIEKEKFA----ERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQD 1086

Query: 1089 FLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGL-TGC 1147
             LC  L  Y  AC      +  WRT   C   CP+   +    + C  SC +LS     C
Sbjct: 1087 CLCTILGNYVKACAEKETYIVGWRT-GLCEHSCPSGLVFKYNVKACNSSCRSLSERDRSC 1145

Query: 1148 TTR--CFEGCECDD-RFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSS 1204
                   +GC C D  +  ++G C+    C C  N   +     +   D   +C C    
Sbjct: 1146 DVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPGKLIHIDD--NKCVCRDGI 1203

Query: 1205 GLTCQ 1209
             L CQ
Sbjct: 1204 -LLCQ 1207



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 96/389 (24%), Positives = 151/389 (38%), Gaps = 32/389 (8%)

Query: 63   GQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTT 121
            G   C  N  +  C ++G+ H  +FDG+ + F G C Y      C   +      F + T
Sbjct: 1304 GSWSCTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGT----FRILT 1359

Query: 122  KNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            ++       ++  R + VA    NI +     GKV       +    +     S+     
Sbjct: 1360 ESVPCCEDGLTCSRKIIVAFQDQNIVLQD---GKVTAVKSTESKKCELNANAYSIHTVGL 1416

Query: 182  KALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPI 241
              +L    G+ V +D N R+ V L  +++G VCGLCGN + +  +D      ++A     
Sbjct: 1417 YLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALE 1476

Query: 242  WGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPE 301
            +G SW+       C D    + P C  +   +      C  L   T   F  CH  V P 
Sbjct: 1477 FGNSWKT---SQECSDTVAQTFP-CDSNPYCKAWAVRKCEILRDST---FRDCHNKVDPS 1529

Query: 302  SFFKGCVLDVCMGG--GDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENS--- 356
            ++   C+ + C     G +   C A+A Y  AC A GV +  WR    C + C   +   
Sbjct: 1530 AYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVCV-SWRKPNLCPVYCDYYNAPG 1588

Query: 357  ----HYEVCGPPCPASCPSP-APLTTPAVCEGPCVEGCQCDAGFV-LSADRCVPLNNGCG 410
                HYE CG     +C          ++ EG C   C   A ++  +  +CV L+  C 
Sbjct: 1589 ECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEG-CYAKCPDSAPYLDENTMKCVSLSE-CS 1646

Query: 411  CWANGTYHEAGSEFWADGTCSQWCRCGPG 439
            C+ N      G     +  C + C C  G
Sbjct: 1647 CFYNDVIPAGGV---IEDNCGRTCYCIAG 1672



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 105/457 (22%), Positives = 172/457 (37%), Gaps = 55/457 (12%)

Query: 5    ECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGG- 63
            EC   C+ P+    D +  +G  +L    P +    +  P       C  Q TC++    
Sbjct: 789  ECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQDAKWS 848

Query: 64   --QGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPF---- 117
              + +C       C + G     +FDG K++F G C+++        +S + L P     
Sbjct: 849  CTEALC----PGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHNEDWSISVE-LRPCPSGQ 902

Query: 118  TVTTKNE-----NRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADG 172
            T T  N      N   P   YV         ++ ++  D   K+R  G   +        
Sbjct: 903  TGTCLNSVTLLLNSSVPVDKYV-------FNSDGTVTND---KIRNQGYYYS-------D 945

Query: 173  RISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQV 229
            +I +   +S  L V  +    LQ+      ++ V++P +      GLCG+ +    +D +
Sbjct: 946  KIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFM 1005

Query: 230  FPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGG 289
                 L  +   +  SW        C      SC +  +++  +      CG L   + G
Sbjct: 1006 SSQNILEKTSQAFANSWEMMS----CPKGNPSSCISIEKEKFAERH----CGILL-DSSG 1056

Query: 290  PFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCE 349
            P  +CH  V P+ + + C    C      D LC  L +YV AC      I  WR  + CE
Sbjct: 1057 PLASCHPIVNPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRTGL-CE 1115

Query: 350  ITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQC-DAGFVLSADRCVPLNNG 408
             +CP    ++     C +SC S +        E   V+GC C DA +  +   CV L + 
Sbjct: 1116 HSCPSGLVFKYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCV-LKSQ 1174

Query: 409  CGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 445
            C C+ N    + G     D       +C    G L+C
Sbjct: 1175 CDCYINDEVMQPGKLIHIDDN-----KCVCRDGILLC 1206



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 33/200 (16%)

Query: 1060 FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAV-KPWRTDS--F 1116
            F  C  V + S  ++    D   Q  DK   C + +  +  C + G    + WR+DS   
Sbjct: 697  FEKCGKVAALSNDYKMICIDEYCQTRDKTSTCDTYSELSRLCASDGPGTFESWRSDSDVV 756

Query: 1117 CPLH-CPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLL----SQGVCIPV 1171
            C    CP    Y  C  +   +C+ ++      + C  GC C + +LL     +G C+  
Sbjct: 757  CETQRCPEQHIYKECGPSNPATCSNVAPFQD--SECVSGCTCPEGYLLDDIGEKGKCVLK 814

Query: 1172 QDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWA 1230
             +C C  +G  Y P    +    C  +C+C  +   +C  A C PGR C+V+        
Sbjct: 815  AECPCESSGTVYQP--GEVREGPCGSQCTCQDAK-WSCTEALC-PGR-CKVE-------- 861

Query: 1231 TRGLCVLSVGANLTTFDGAR 1250
                     G++LTTFDG +
Sbjct: 862  ---------GSSLTTFDGVK 872



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 58/235 (24%), Positives = 97/235 (41%), Gaps = 26/235 (11%)

Query: 1151 CFEGCECDDRFLL-SQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQ 1209
            C  GC C +  +  S+G+C+   DC C+  GR      S+ +  C+E C+C   S  +C 
Sbjct: 1253 CKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYD-EGSVTSVGCNE-CTCIKGSW-SCT 1309

Query: 1210 AAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQ 1269
               C    +C +  E                 ++ TFDG   +      Y       G +
Sbjct: 1310 QNECQT--ICHIYGEG----------------HVRTFDGKSYSFDGLCQYSFLEDYCGHE 1351

Query: 1270 NTIPWYRVVAE-VQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASV 1328
            N    +R++ E V  C        ++ + FQD  + L   K   V         E  A+ 
Sbjct: 1352 NGT--FRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTE-SKKCELNANA 1408

Query: 1329 SVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
                T    L+++ + G+ V    N +++VI+  +  GK+CG CGN +GD  +D+
Sbjct: 1409 YSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDF 1463


>gi|239744587 PREDICTED: hypothetical protein XP_002343203 [Homo
            sapiens]
          Length = 2134

 Score =  144 bits (363), Expect = 6e-34
 Identities = 139/532 (26%), Positives = 207/532 (38%), Gaps = 89/532 (16%)

Query: 769  CREGCVCDAGFVL-SGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTC 827
            C+ GC C  G V  S   CV    C C   GR Y  G V   G  C    EC      TC
Sbjct: 1253 CKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVG--CN---EC------TC 1301

Query: 828  QEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSY-VLAQVC 886
             +G+      EC+       CH  G G        H  T DG+ Y   G C Y  L   C
Sbjct: 1302 IKGSWSCTQNECQT-----ICHIYGEG--------HVRTFDGKSYSFDGLCQYSFLEDYC 1348

Query: 887  HPKPGDEDFSIVLE-----KNAAGDLQRLLVTVAGQVVSLAQGQQVTVDG-EAVALPVAV 940
              + G   F I+ E     ++     ++++V    Q + L  G+   V   E+    +  
Sbjct: 1349 GHENGT--FRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTESKKCELNA 1406

Query: 941  GRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLP 1000
                +   G  ++L+   G+ +++D +  L + +   + G++CGLCGN NG+  DDF   
Sbjct: 1407 NAYSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTR 1466

Query: 1001 NGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESN--------EACGQ 1052
              S AS    FG +W+   +S+ C +             +T P +SN          C  
Sbjct: 1467 YSSVASGALEFGNSWK---TSQECSD----------TVAQTFPCDSNPYCKAWAVRKCEI 1513

Query: 1053 LRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDKAFLCRSLAAYTAACQAAGVAVKP 1110
            LR+    F  C   + PS Y   C+ + CA   +G     C ++A Y  AC A GV V  
Sbjct: 1514 LRD--STFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVCVS- 1570

Query: 1111 WRTDSFCPLHCPAHS-------HYSIC----TRTCQGSCAA---LSGLTGCTTRCFEGCE 1156
            WR  + CP++C  ++       HY  C     +TC+         S L GC  +C +   
Sbjct: 1571 WRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEGCYAKCPDSAP 1630

Query: 1157 CDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG 1216
              D   +    C+ + +C C +N   +P    ++  +C   C C +   L C     P  
Sbjct: 1631 YLDENTMK---CVSLSECSCFYND-VIPA-GGVIEDNCGRTCYCIAGQ-LECSET-APTN 1683

Query: 1217 RVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTS-PGVYELSSRCPG 1267
                V         T    +LS GA +T   G      S P +   SS   G
Sbjct: 1684 STFAVS-------TTTATTILSTGAAITLVTGGPSTAASIPAITTSSSETTG 1728



 Score =  132 bits (333), Expect = 2e-30
 Identities = 152/599 (25%), Positives = 221/599 (36%), Gaps = 102/599 (17%)

Query: 261  GSCPTCPEDRLEQYE-GPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHD 319
            G CP       E  E G   C  +    G  F  C       + +K   +D      D  
Sbjct: 669  GDCPNAVGKSYEVCEDGIQHCNKII---GTYFEKCGKVAALSNDYKMICIDEYCQTRDKT 725

Query: 320  ILCKALASYVAACQAAGV-VIEDWRAQ--VGCEIT-CPENSHYEVCGPPCPASCPSPAPL 375
              C   +     C + G    E WR+   V C    CPE   Y+ CGP  PA+C + AP 
Sbjct: 726  STCDTYSELSRLCASDGPGTFESWRSDSDVVCGTQRCPEQHIYKECGPSNPATCSNVAPF 785

Query: 376  TTPAVCEGPCVEGCQCDAGFVLS----ADRCVPLNNGCGCWANGTYHEAGSEFWADGTCS 431
                  +  CV GC C  G++L       +CV L   C C ++GT ++ G     +G C 
Sbjct: 786  Q-----DSECVSGCTCPEGYLLDDIGEKGKCV-LKAECPCESSGTVYQPGEV--REGPCG 837

Query: 432  QWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFD 491
              C C     S  CT A C                       C+  G     T DG +++
Sbjct: 838  SQCTCQDAKWS--CTEALC--------------------PGRCKVEGSS-LTTFDGVKYN 874

Query: 492  FQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGS-QAVSYTRSVTL----------QIYN 540
            F G C +L         +  E+++++V      S Q  +   SVTL           ++N
Sbjct: 875  FPGNCHFLA--------VHNEDWSISVELRPCPSGQTGTCLNSVTLLLNSSVPVDKYVFN 926

Query: 541  HSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLR 600
               T++     K++  G + +   Q+ +   ++L      V T   + L       ++L 
Sbjct: 927  SDGTVTND---KIRNQGYYYSDKIQIFNASSSYLQ-----VETYFHVKLQIQIVPVMQLY 978

Query: 601  V--PAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSKPC 650
            V  P        GLCG+YN    DD         K        W++     C     K  
Sbjct: 979  VSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEM---MSC----PKGN 1031

Query: 651  PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCP 710
            PS C   ++E F     CG++  + GPLA CH +V P  Y + C    C  +     LC 
Sbjct: 1032 PSSCISIEKEKFAERH-CGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQDCLCT 1090

Query: 711  AVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPE---GCES 767
             +  YV AC      +  W R   C   CP+   ++    +C  SC SLS  +     E 
Sbjct: 1091 ILGNYVKACAEKETYIVGW-RTGLCEHSCPSGLVFKYNVKACNSSCRSLSERDRSCDVED 1149

Query: 768  ACREGCVC-DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPEC---ERRCECGPG 822
               +GC C DA +  +   CV   QC C      Y   EV  PG      + +C C  G
Sbjct: 1150 VPVDGCTCPDAMYQNNEGNCVLKSQCDC------YINDEVMQPGKLIHIDDNKCVCRDG 1202



 Score =  127 bits (319), Expect = 8e-29
 Identities = 124/482 (25%), Positives = 191/482 (39%), Gaps = 87/482 (18%)

Query: 384  PCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSL 443
            PC  GC C  G V ++       N C C   G  ++ GS       C++ C C  G  S 
Sbjct: 1252 PCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSV--TSVGCNE-CTCIKGSWS- 1307

Query: 444  VCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEY-LLSA 502
             CT                Q+ CQ +    C  +G+ H  T DG  + F G C+Y  L  
Sbjct: 1308 -CT----------------QNECQTI----CHIYGEGHVRTFDGKSYSFDGLCQYSFLED 1346

Query: 503  PCHGPPLGAENFTVTVANEHRG--SQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFV 560
             C     G EN T  +  E        ++ +R + +   + ++ L          DG   
Sbjct: 1347 YC-----GHENGTFRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQ---------DGKVT 1392

Query: 561  ALPF------QLDSLLHA-HLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLC 613
            A+        +L++  ++ H  G  +++   +G+ + +D ++ + + +   +   +CGLC
Sbjct: 1393 AVKSTESKKCELNANAYSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLC 1452

Query: 614  GNYNQDPADDLK------AVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDA 667
            GN N D  DD        A G    G     +Q C + V++    PC             
Sbjct: 1453 GNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQ--TFPCDSNPYCKAWAVRK 1510

Query: 668  CGVISATDGPLAPCHGLVPPAQYFQGCLLD--ACQVQGHPGGLCPAVATYVAACQAAGAQ 725
            C ++   D     CH  V P+ Y   C+ +  AC ++G   G C AVA Y  AC A G  
Sbjct: 1511 CEIL--RDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVC 1568

Query: 726  LGEWRRPDFCPLQCPAHS-------HYELCGDSCPVSCPS-------LSAPEGCESACRE 771
            +  WR+P+ CP+ C  ++       HYE CG     +C          S  EGC + C  
Sbjct: 1569 V-SWRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEGCYAKCP- 1626

Query: 772  GCVCDAGFVLSGDT--CVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQE 829
                D+   L  +T  CV + +C C ++    P G V      C R C C   G + C E
Sbjct: 1627 ----DSAPYLDENTMKCVSLSECSCFYND-VIPAGGVI--EDNCGRTCYC-IAGQLECSE 1678

Query: 830  GA 831
             A
Sbjct: 1679 TA 1680



 Score =  126 bits (317), Expect = 1e-28
 Identities = 131/545 (24%), Positives = 194/545 (35%), Gaps = 80/545 (14%)

Query: 694  CLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD---FCPLQ-CPAHSHYELCG 749
            C+ + CQ +      C   +     C + G    E  R D    C  Q CP    Y+ CG
Sbjct: 714  CIDEYCQTRDKTS-TCDTYSELSRLCASDGPGTFESWRSDSDVVCGTQRCPEQHIYKECG 772

Query: 750  DSCPVSCPSLSAPEGCESACREGCVCDAGFVLSG----DTCVPVGQCGCLHDGRYYPLGE 805
             S P +C +++  +  +S C  GC C  G++L        CV   +C C   G  Y  GE
Sbjct: 773  PSNPATCSNVAPFQ--DSECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGE 830

Query: 806  VFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHY 864
            V        R   CG                 +C  +D   +C    C GRC   G    
Sbjct: 831  V--------REGPCG----------------SQCTCQDAKWSCTEALCPGRCKVEGS-SL 865

Query: 865  ITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQG 924
             T DG  Y+  G+C ++          +ED+SI +E       Q          V+L   
Sbjct: 866  TTFDGVKYNFPGNCHFLAVH-------NEDWSISVELRPCPSGQ---TGTCLNSVTLLLN 915

Query: 925  QQVTVDGEAVALPVAVGRVRVTAEG------------RNMVLQTTK----GLRLLFDGDA 968
              V VD         V   ++  +G             +  LQ        L++      
Sbjct: 916  SSVPVDKYVFNSDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQIQIVPVM 975

Query: 969  HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGC 1028
             L +S+P        GLCG++N    DDF+        + + F  +W +    KG     
Sbjct: 976  QLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMSCPKG----- 1030

Query: 1029 GPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKA 1088
             P  C     E+ A       CG L +  GP A+C  +++P  Y  +C    C  +  + 
Sbjct: 1031 NPSSCISIEKEKFA----ERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQD 1086

Query: 1089 FLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGL-TGC 1147
             LC  L  Y  AC      +  WRT   C   CP+   +    + C  SC +LS     C
Sbjct: 1087 CLCTILGNYVKACAEKETYIVGWRT-GLCEHSCPSGLVFKYNVKACNSSCRSLSERDRSC 1145

Query: 1148 TTR--CFEGCECDD-RFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSS 1204
                   +GC C D  +  ++G C+    C C  N   +     +   D   +C C    
Sbjct: 1146 DVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPGKLIHIDD--NKCVCRDGI 1203

Query: 1205 GLTCQ 1209
             L CQ
Sbjct: 1204 -LLCQ 1207



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 96/389 (24%), Positives = 151/389 (38%), Gaps = 32/389 (8%)

Query: 63   GQGVCLPNY-EATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFTVTT 121
            G   C  N  +  C ++G+ H  +FDG+ + F G C Y      C   +      F + T
Sbjct: 1304 GSWSCTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGT----FRILT 1359

Query: 122  KNENRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGAS 181
            ++       ++  R + VA    NI +     GKV       +    +     S+     
Sbjct: 1360 ESVPCCEDGLTCSRKIIVAFQDQNIVLQD---GKVTAVKSTESKKCELNANAYSIHTVGL 1416

Query: 182  KALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPI 241
              +L    G+ V +D N R+ V L  +++G VCGLCGN + +  +D      ++A     
Sbjct: 1417 YLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALE 1476

Query: 242  WGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPE 301
            +G SW+       C D    + P C  +   +      C  L   T   F  CH  V P 
Sbjct: 1477 FGNSWKT---SQECSDTVAQTFP-CDSNPYCKAWAVRKCEILRDST---FRDCHNKVDPS 1529

Query: 302  SFFKGCVLDVCMGG--GDHDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENS--- 356
            ++   C+ + C     G +   C A+A Y  AC A GV +  WR    C + C   +   
Sbjct: 1530 AYHDVCIEEACACDMEGKYLGFCTAVAMYAEACSAVGVCV-SWRKPNLCPVYCDYYNAPG 1588

Query: 357  ----HYEVCGPPCPASCPSP-APLTTPAVCEGPCVEGCQCDAGFV-LSADRCVPLNNGCG 410
                HYE CG     +C          ++ EG C   C   A ++  +  +CV L+  C 
Sbjct: 1589 ECRWHYEPCGTVTAKTCKDQLVGQKFSSLLEG-CYAKCPDSAPYLDENTMKCVSLSE-CS 1646

Query: 411  CWANGTYHEAGSEFWADGTCSQWCRCGPG 439
            C+ N      G     +  C + C C  G
Sbjct: 1647 CFYNDVIPAGGV---IEDNCGRTCYCIAG 1672



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 105/457 (22%), Positives = 172/457 (37%), Gaps = 55/457 (12%)

Query: 5    ECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGG- 63
            EC   C+ P+    D +  +G  +L    P +    +  P       C  Q TC++    
Sbjct: 789  ECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQDAKWS 848

Query: 64   --QGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPF---- 117
              + +C       C + G     +FDG K++F G C+++        +S + L P     
Sbjct: 849  CTEALC----PGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHNEDWSISVE-LRPCPSGQ 902

Query: 118  TVTTKNE-----NRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADG 172
            T T  N      N   P   YV         ++ ++  D   K+R  G   +        
Sbjct: 903  TGTCLNSVTLLLNSSVPVDKYV-------FNSDGTVTND---KIRNQGYYYS-------D 945

Query: 173  RISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQV 229
            +I +   +S  L V  +    LQ+      ++ V++P +      GLCG+ +    +D +
Sbjct: 946  KIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFM 1005

Query: 230  FPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGG 289
                 L  +   +  SW        C      SC +  +++  +      CG L   + G
Sbjct: 1006 SSQNILEKTSQAFANSWEMMS----CPKGNPSSCISIEKEKFAERH----CGILL-DSSG 1056

Query: 290  PFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCE 349
            P  +CH  V P+ + + C    C      D LC  L +YV AC      I  WR  + CE
Sbjct: 1057 PLASCHPIVNPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRTGL-CE 1115

Query: 350  ITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQC-DAGFVLSADRCVPLNNG 408
             +CP    ++     C +SC S +        E   V+GC C DA +  +   CV L + 
Sbjct: 1116 HSCPSGLVFKYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCV-LKSQ 1174

Query: 409  CGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 445
            C C+ N    + G     D       +C    G L+C
Sbjct: 1175 CDCYINDEVMQPGKLIHIDDN-----KCVCRDGILLC 1206



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 33/200 (16%)

Query: 1060 FATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAV-KPWRTDS--F 1116
            F  C  V + S  ++    D   Q  DK   C + +  +  C + G    + WR+DS   
Sbjct: 697  FEKCGKVAALSNDYKMICIDEYCQTRDKTSTCDTYSELSRLCASDGPGTFESWRSDSDVV 756

Query: 1117 CPLH-CPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLL----SQGVCIPV 1171
            C    CP    Y  C  +   +C+ ++      + C  GC C + +LL     +G C+  
Sbjct: 757  CGTQRCPEQHIYKECGPSNPATCSNVAPFQD--SECVSGCTCPEGYLLDDIGEKGKCVLK 814

Query: 1172 QDCGCTHNGR-YLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWA 1230
             +C C  +G  Y P    +    C  +C+C  +   +C  A C PGR C+V+        
Sbjct: 815  AECPCESSGTVYQP--GEVREGPCGSQCTCQDAK-WSCTEALC-PGR-CKVE-------- 861

Query: 1231 TRGLCVLSVGANLTTFDGAR 1250
                     G++LTTFDG +
Sbjct: 862  ---------GSSLTTFDGVK 872



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 58/235 (24%), Positives = 97/235 (41%), Gaps = 26/235 (11%)

Query: 1151 CFEGCECDDRFLL-SQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQ 1209
            C  GC C +  +  S+G+C+   DC C+  GR      S+ +  C+E C+C   S  +C 
Sbjct: 1253 CKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYD-EGSVTSVGCNE-CTCIKGSW-SCT 1309

Query: 1210 AAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQ 1269
               C    +C +  E                 ++ TFDG   +      Y       G +
Sbjct: 1310 QNECQT--ICHIYGEG----------------HVRTFDGKSYSFDGLCQYSFLEDYCGHE 1351

Query: 1270 NTIPWYRVVAE-VQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASV 1328
            N    +R++ E V  C        ++ + FQD  + L   K   V         E  A+ 
Sbjct: 1352 NGT--FRILTESVPCCEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTE-SKKCELNANA 1408

Query: 1329 SVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDW 1383
                T    L+++ + G+ V    N +++VI+  +  GK+CG CGN +GD  +D+
Sbjct: 1409 YSIHTVGLYLILKFQNGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDF 1463


>gi|239755776 PREDICTED: similar to Mucin-19 [Homo sapiens]
          Length = 1950

 Score =  134 bits (336), Expect = 8e-31
 Identities = 143/552 (25%), Positives = 210/552 (38%), Gaps = 99/552 (17%)

Query: 307  CVLDVCMGGGDHDILCKALASYVAACQAAGV-VIEDWRAQ--VGCEIT-CPENSHYEVCG 362
            C+ + C    D    C   +     C + G    E WR+   V CE   CPE   Y+ CG
Sbjct: 692  CIDEYCQTR-DKTSTCDTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYKECG 750

Query: 363  PPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLS----ADRCVPLNNGCGCWANGTYH 418
            P  PA+C + AP       +  CV GC C  G++L       +CV L   C C ++GT +
Sbjct: 751  PSNPATCSNVAPFQ-----DSECVSGCTCPEGYLLDDIGEKGKCV-LKAECPCESSGTVY 804

Query: 419  EAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWG 478
            + G     +G C   C C     S  CT A C                       C+  G
Sbjct: 805  QPGEV--REGPCGSQCTCQDAKWS--CTEALC--------------------PGRCKVEG 840

Query: 479  DPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGS-QAVSYTRSVTL- 536
                 T DG +++F G C +L         +  E+++++V      S Q  +   SVTL 
Sbjct: 841  SS-LTTFDGVKYNFPGNCHFLA--------VHNEDWSISVELRPCPSGQTGTCLNSVTLL 891

Query: 537  ---------QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGL 587
                      ++N   T++     K++  G + +   Q+ +   ++L      V T   +
Sbjct: 892  LNSSVPVDKYVFNSDGTVTND---KIRNQGYYYSDKIQIFNASSSYLQ-----VETYFHV 943

Query: 588  SLAFDGDSFVRLRV--PAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVG 637
             L       ++L V  P        GLCG+YN    DD         K        W++ 
Sbjct: 944  KLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEM- 1002

Query: 638  GAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLD 697
                C     K  PS C   ++E F     CG++  + GPLA CH +V P  Y + C   
Sbjct: 1003 --MSC----PKGNPSSCISIEKEKFAERH-CGILLDSSGPLASCHPIVNPKPYHEECKKY 1055

Query: 698  ACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCP 757
             C  +     LC  +  YV AC      +  W R   C   CP+   ++    +C  SC 
Sbjct: 1056 TCTCENSQDCLCTILGNYVKACAEKETYIVGW-RTGLCEHSCPSGLVFKYNVKACNSSCR 1114

Query: 758  SLSAPE---GCESACREGCVC-DAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGP-- 811
            SLS  +     E    +GC C DA +  +   CV   QC C      Y   EV  PG   
Sbjct: 1115 SLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDC------YINDEVMQPGKLI 1168

Query: 812  -ECERRCECGPG 822
               + +C C  G
Sbjct: 1169 HTDDNKCVCRDG 1180



 Score =  131 bits (329), Expect = 5e-30
 Identities = 139/589 (23%), Positives = 206/589 (34%), Gaps = 92/589 (15%)

Query: 650  CPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLC 709
            CP+      +    G   CG ++A                Y   C+ + CQ +      C
Sbjct: 660  CPNAVGKSYEVCEDGIQKCGKVAALSN------------DYKMICIDEYCQTRDKTS-TC 706

Query: 710  PAVATYVAACQAAGAQLGEWRRPD---FCPLQ-CPAHSHYELCGDSCPVSCPSLSAPEGC 765
               +     C + G    E  R D    C  Q CP    Y+ CG S P +C +++  +  
Sbjct: 707  DTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYKECGPSNPATCSNVAPFQ-- 764

Query: 766  ESACREGCVCDAGFVLSG----DTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGP 821
            +S C  GC C  G++L        CV   +C C   G  Y  GEV        R   CG 
Sbjct: 765  DSECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEV--------REGPCG- 815

Query: 822  GGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSY 880
                            +C  +D   +C    C GRC   G     T DG  Y+  G+C +
Sbjct: 816  ---------------SQCTCQDAKWSCTEALCPGRCKVEGS-SLTTFDGVKYNFPGNCHF 859

Query: 881  VLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAV 940
            +          +ED+SI +E       Q          V+L     V VD         V
Sbjct: 860  LAVH-------NEDWSISVELRPCPSGQ---TGTCLNSVTLLLNSSVPVDKYVFNSDGTV 909

Query: 941  GRVRVTAEG------------RNMVLQTTK----GLRLLFDGDAHLLMSIPSPFRGRLCG 984
               ++  +G             +  LQ        L++       L +S+P        G
Sbjct: 910  TNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVG 969

Query: 985  LCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPY 1044
            LCG++N    DDF+        + + F  +W +    KG      P  C     E+ A  
Sbjct: 970  LCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMSCPKG-----NPSSCISIEKEKFA-- 1022

Query: 1045 ESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAA 1104
                 CG L +  GP A+C  +++P  Y  +C    C  +  +  LC  L  Y  AC   
Sbjct: 1023 --ERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEK 1080

Query: 1105 GVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGL-TGCTTR--CFEGCECDD-R 1160
               +  WRT   C   CP+   +    + C  SC +LS     C       +GC C D  
Sbjct: 1081 ETYIVGWRT-GLCEHSCPSGLVFKYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAM 1139

Query: 1161 FLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQ 1209
            +  ++G C+    C C  N   +     + T D   +C C     L CQ
Sbjct: 1140 YQNNEGNCVLKSQCDCYINDEVMQPGKLIHTDD--NKCVCRDGI-LLCQ 1185



 Score =  103 bits (258), Expect = 9e-22
 Identities = 86/315 (27%), Positives = 126/315 (40%), Gaps = 55/315 (17%)

Query: 978  FRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCL 1037
            F+G++CGLCGN NG+  DDF     S AS    FG +W+   +S+ C +           
Sbjct: 1260 FQGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWK---TSQECSD----------T 1306

Query: 1038 AEETAPYESN--------EACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCA--QKGDK 1087
              +T P +SN          C  LR+    F  C   + PS Y   C+ + CA   +G  
Sbjct: 1307 VAQTFPCDSNPYCKAWAVRKCEILRD--STFRDCHNKVDPSAYHDVCIEEACACDMEGKY 1364

Query: 1088 AFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHS-------HYSIC----TRTCQG 1136
               C ++A Y  AC A GV V  WR  + CP++C  ++       HY  C     +TC+ 
Sbjct: 1365 LGFCTAVAMYAEACSAVGVCVS-WRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKD 1423

Query: 1137 SCAA---LSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSD 1193
                    S L GC  +C +     D   +    C+ + +C C +N   +P    ++  +
Sbjct: 1424 QLVGQKFSSLLEGCYAKCPDSAPYLDENTMK---CVSLSECSCFYND-VIPA-GGVIEDN 1478

Query: 1194 CSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGAT 1253
            C   C C +   L C     P      V         T    +LS GA +T   G     
Sbjct: 1479 CGRTCYCIAGQ-LECSET-APTNSTFAVS-------TTTATTILSTGAAITLVTGGPSTA 1529

Query: 1254 TS-PGVYELSSRCPG 1267
             S P +   SS   G
Sbjct: 1530 ASIPAITTSSSETTG 1544



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 75/256 (29%), Positives = 106/256 (41%), Gaps = 38/256 (14%)

Query: 600  RVPAAYAASLCGLCGNYNQDPADDLK------AVGGKPAGWQVGGAQGCGECVSKPCPSP 653
            ++  A+   +CGLCGN N D  DD        A G    G     +Q C + V++  P  
Sbjct: 1255 KIIVAFQGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQTFPCD 1314

Query: 654  CTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDAC--QVQGHPGGLCPA 711
              P  +        C ++   D     CH  V P+ Y   C+ +AC   ++G   G C A
Sbjct: 1315 SNPYCKA--WAVRKCEILR--DSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTA 1370

Query: 712  VATYVAACQAAGAQLGEWRRPDFCPLQCPAHS-------HYELCGDSCPVSCPS------ 758
            VA Y  AC A G  +  WR+P+ CP+ C  ++       HYE CG     +C        
Sbjct: 1371 VAMYAEACSAVGVCV-SWRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQK 1429

Query: 759  -LSAPEGCESACREGCVCDAGFVLSGDT--CVPVGQCGCLHDGRYYPLGEVFYPGPECER 815
              S  EGC + C      D+   L  +T  CV + +C C ++    P G V      C R
Sbjct: 1430 FSSLLEGCYAKCP-----DSAPYLDENTMKCVSLSECSCFYND-VIPAGGVI--EDNCGR 1481

Query: 816  RCECGPGGHVTCQEGA 831
             C C   G + C E A
Sbjct: 1482 TCYC-IAGQLECSETA 1496



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 105/457 (22%), Positives = 172/457 (37%), Gaps = 55/457 (12%)

Query: 5    ECGLACSNPQIPGTDWVDMEGAAMLYNGQPLKVLLPLLSPDPCHGVTCRPQETCKEQGG- 63
            EC   C+ P+    D +  +G  +L    P +    +  P       C  Q TC++    
Sbjct: 767  ECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQDAKWS 826

Query: 64   --QGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPF---- 117
              + +C       C + G     +FDG K++F G C+++        +S + L P     
Sbjct: 827  CTEALC----PGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHNEDWSISVE-LRPCPSGQ 880

Query: 118  TVTTKNE-----NRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADG 172
            T T  N      N   P   YV         ++ ++  D   K+R  G   +        
Sbjct: 881  TGTCLNSVTLLLNSSVPVDKYV-------FNSDGTVTND---KIRNQGYYYS-------D 923

Query: 173  RISVAQGASKALLVADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQV 229
            +I +   +S  L V  +    LQ+      ++ V++P +      GLCG+ +    +D +
Sbjct: 924  KIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFM 983

Query: 230  FPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGG 289
                 L  +   +  SW        C      SC +  +++  +      CG L   +G 
Sbjct: 984  SSQNILEKTSQAFANSWEMMS----CPKGNPSSCISIEKEKFAERH----CGILLDSSG- 1034

Query: 290  PFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDWRAQVGCE 349
            P  +CH  V P+ + + C    C      D LC  L +YV AC      I  WR  + CE
Sbjct: 1035 PLASCHPIVNPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRTGL-CE 1093

Query: 350  ITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQC-DAGFVLSADRCVPLNNG 408
             +CP    ++     C +SC S +        E   V+GC C DA +  +   CV L + 
Sbjct: 1094 HSCPSGLVFKYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCV-LKSQ 1152

Query: 409  CGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 445
            C C+ N    + G     D       +C    G L+C
Sbjct: 1153 CDCYINDEVMQPGKLIHTDDN-----KCVCRDGILLC 1184



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 63/243 (25%), Positives = 95/243 (39%), Gaps = 24/243 (9%)

Query: 208  SYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCP 267
            ++ G VCGLCGN + +  +D      ++A     +G SW+       C D    + P C 
Sbjct: 1259 AFQGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKT---SQECSDTVAQTFP-CD 1314

Query: 268  EDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGG--GDHDILCKAL 325
             +   +      C  L   T   F  CH  V P ++   C+ + C     G +   C A+
Sbjct: 1315 SNPYCKAWAVRKCEILRDST---FRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAV 1371

Query: 326  ASYVAACQAAGVVIEDWRAQVGCEITCPENS-------HYEVCGPPCPASCPSP-APLTT 377
            A Y  AC A GV +  WR    C + C   +       HYE CG     +C         
Sbjct: 1372 AMYAEACSAVGVCV-SWRKPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQLVGQKF 1430

Query: 378  PAVCEGPCVEGCQCDAGFV-LSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRC 436
             ++ EG C   C   A ++  +  +CV L+  C C+ N      G     +  C + C C
Sbjct: 1431 SSLLEG-CYAKCPDSAPYLDENTMKCVSLSE-CSCFYNDVIPAGGV---IEDNCGRTCYC 1485

Query: 437  GPG 439
              G
Sbjct: 1486 IAG 1488



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 51/197 (25%), Positives = 82/197 (41%), Gaps = 33/197 (16%)

Query: 1063 CQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAV-KPWRTDS--FCPL 1119
            C  V + S  ++    D   Q  DK   C + +  +  C + G    + WR+DS   C  
Sbjct: 678  CGKVAALSNDYKMICIDEYCQTRDKTSTCDTYSELSRLCASDGPGTFESWRSDSDVVCET 737

Query: 1120 H-CPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLL----SQGVCIPVQDC 1174
              CP    Y  C  +   +C+ ++      + C  GC C + +LL     +G C+   +C
Sbjct: 738  QRCPEQHIYKECGPSNPATCSNVAPFQD--SECVSGCTCPEGYLLDDIGEKGKCVLKAEC 795

Query: 1175 GCTHNGR-YLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRG 1233
             C  +G  Y P    +    C  +C+C  +   +C  A C PGR C+V+           
Sbjct: 796  PCESSGTVYQP--GEVREGPCGSQCTCQDAK-WSCTEALC-PGR-CKVE----------- 839

Query: 1234 LCVLSVGANLTTFDGAR 1250
                  G++LTTFDG +
Sbjct: 840  ------GSSLTTFDGVK 850


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.470 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,133,893
Number of Sequences: 37866
Number of extensions: 3825689
Number of successful extensions: 13954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 10279
Number of HSP's gapped (non-prelim): 2088
length of query: 1403
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1288
effective length of database: 13,892,928
effective search space: 17894091264
effective search space used: 17894091264
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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