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Search of human proteins with 119395746
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119395746 Kallmann syndrome 1 protein precursor [Homo
sapiens]
(680 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119395746 Kallmann syndrome 1 protein precursor [Homo sapiens] 1417 0.0
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 56 1e-07
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 56 1e-07
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 56 1e-07
gi|110349719 titin isoform N2-A [Homo sapiens] 51 3e-06
gi|110349717 titin isoform novex-2 [Homo sapiens] 51 3e-06
gi|110349713 titin isoform novex-1 [Homo sapiens] 51 3e-06
gi|110349715 titin isoform N2-B [Homo sapiens] 51 3e-06
gi|32307109 WAP four-disulfide core domain 3 precursor [Homo sap... 51 3e-06
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 50 7e-06
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 50 7e-06
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 50 7e-06
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 50 7e-06
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 50 7e-06
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 49 2e-05
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 49 2e-05
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 49 2e-05
gi|56699495 WAP four-disulfide core domain 2 precursor [Homo sap... 46 1e-04
gi|153946389 WAP four-disulfide core domain 8 precursor [Homo sa... 46 1e-04
gi|153946387 WAP four-disulfide core domain 8 precursor [Homo sa... 46 1e-04
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 44 5e-04
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 43 0.001
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 43 0.001
gi|156104903 myomesin 2 [Homo sapiens] 43 0.001
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 42 0.002
gi|222352127 sidekick 2 [Homo sapiens] 42 0.002
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ... 42 0.002
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [... 42 0.002
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 42 0.002
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 42 0.002
>gi|119395746 Kallmann syndrome 1 protein precursor [Homo sapiens]
Length = 680
Score = 1417 bits (3667), Expect = 0.0
Identities = 680/680 (100%), Positives = 680/680 (100%)
Query: 1 MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITR 60
MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITR
Sbjct: 1 MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITR 60
Query: 61 ISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSC 120
ISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSC
Sbjct: 61 ISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSC 120
Query: 121 EFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYK 180
EFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYK
Sbjct: 121 EFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYK 180
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV
Sbjct: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
Query: 241 AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN
Sbjct: 241 AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
Query: 301 STVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
STVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI
Sbjct: 301 STVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
Query: 361 LEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPF 420
LEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPF
Sbjct: 361 LEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPF 420
Query: 421 QRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSG 480
QRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSG
Sbjct: 421 QRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSG 480
Query: 481 MTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEA 540
MTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEA
Sbjct: 481 MTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEA 540
Query: 541 GHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNS 600
GHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNS
Sbjct: 541 GHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNS 600
Query: 601 LPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSA 660
LPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSA
Sbjct: 601 LPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSA 660
Query: 661 HRSHLKHRHPHHYKPSPERY 680
HRSHLKHRHPHHYKPSPERY
Sbjct: 661 HRSHLKHRHPHHYKPSPERY 680
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/385 (21%), Positives = 142/385 (36%), Gaps = 74/385 (19%)
Query: 288 SAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKK 347
S P P RL S ++ V + W E+ + P+ Y + + K + P K
Sbjct: 606 SPGPVP---RLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFE----DKEMAPEKWY 658
Query: 348 RRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLV 407
G Q S L KL P Y + AI +G + + VS + A K +
Sbjct: 659 SLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPG--EPSPVSETVVTPEAAPEKNPVD 715
Query: 408 KTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEAC 467
+G T + + P R ++ AP Q Y V+W P+
Sbjct: 716 VKGEGNETTNMVITWK-PLRWMDWNAPQVQ--------------------YRVQWRPQG- 753
Query: 468 AHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALK 527
T + + ++++ + S Y++ VQ + +
Sbjct: 754 -----TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQ------------------- 789
Query: 528 GKSHKPVGCLGEAGHVLSKVLAKPENL----SASFIVQDVNITGHFSWKMAK-ANLYQPM 582
GK +P +G +G + + + E + S++ +V+ W+ A + +
Sbjct: 790 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVK---------WRPVDLAQVKGHL 840
Query: 583 TGFQVT-WAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGG 641
G+ VT W E S++ I ++P++ + + LRP + Y LEVQ G
Sbjct: 841 RGYNVTYWRE---GSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897
Query: 642 EGPATIKTFRTPELPPSSAHRSHLK 666
GPA+ TF TPE P HL+
Sbjct: 898 SGPASEFTFSTPEGVPGHPEALHLE 922
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/385 (21%), Positives = 142/385 (36%), Gaps = 74/385 (19%)
Query: 288 SAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKK 347
S P P RL S ++ V + W E+ + P+ Y + + K + P K
Sbjct: 611 SPGPVP---RLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFE----DKEMAPEKWY 663
Query: 348 RRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLV 407
G Q S L KL P Y + AI +G + + VS + A K +
Sbjct: 664 SLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPG--EPSPVSETVVTPEAAPEKNPVD 720
Query: 408 KTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEAC 467
+G T + + P R ++ AP Q Y V+W P+
Sbjct: 721 VKGEGNETTNMVITWK-PLRWMDWNAPQVQ--------------------YRVQWRPQG- 758
Query: 468 AHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALK 527
T + + ++++ + S Y++ VQ + +
Sbjct: 759 -----TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQ------------------- 794
Query: 528 GKSHKPVGCLGEAGHVLSKVLAKPENL----SASFIVQDVNITGHFSWKMAK-ANLYQPM 582
GK +P +G +G + + + E + S++ +V+ W+ A + +
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVK---------WRPVDLAQVKGHL 845
Query: 583 TGFQVT-WAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGG 641
G+ VT W E S++ I ++P++ + + LRP + Y LEVQ G
Sbjct: 846 RGYNVTYWRE---GSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 642 EGPATIKTFRTPELPPSSAHRSHLK 666
GPA+ TF TPE P HL+
Sbjct: 903 SGPASEFTFSTPEGVPGHPEALHLE 927
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/385 (21%), Positives = 142/385 (36%), Gaps = 74/385 (19%)
Query: 288 SAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKK 347
S P P RL S ++ V + W E+ + P+ Y + + K + P K
Sbjct: 611 SPGPVP---RLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFE----DKEMAPEKWY 663
Query: 348 RRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLV 407
G Q S L KL P Y + AI +G + + VS + A K +
Sbjct: 664 SLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPG--EPSPVSETVVTPEAAPEKNPVD 720
Query: 408 KTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEAC 467
+G T + + P R ++ AP Q Y V+W P+
Sbjct: 721 VKGEGNETTNMVITWK-PLRWMDWNAPQVQ--------------------YRVQWRPQG- 758
Query: 468 AHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALK 527
T + + ++++ + S Y++ VQ + +
Sbjct: 759 -----TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQ------------------- 794
Query: 528 GKSHKPVGCLGEAGHVLSKVLAKPENL----SASFIVQDVNITGHFSWKMAK-ANLYQPM 582
GK +P +G +G + + + E + S++ +V+ W+ A + +
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVK---------WRPVDLAQVKGHL 845
Query: 583 TGFQVT-WAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGG 641
G+ VT W E S++ I ++P++ + + LRP + Y LEVQ G
Sbjct: 846 RGYNVTYWRE---GSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 642 EGPATIKTFRTPELPPSSAHRSHLK 666
GPA+ TF TPE P HL+
Sbjct: 903 SGPASEFTFSTPEGVPGHPEALHLE 927
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 15/162 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + + + W V + T D R ++T + + YQ+RV AVN G F+ PS+ ++
Sbjct: 27100 YFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYK 27159
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKVFWSWMVSSKS 340
++ DP PP PA +R+A+ST +S +T+ W P + V Y V +
Sbjct: 27160 AA-DPIDPPGPPAKIRIADSTKSS-----ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 27213
Query: 341 LVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQ 382
+ K +TT+ ++ L+P +Y + A+ GQ
Sbjct: 27214 TTVSTKGEVRTTE-----YVVSNLKPGVNYYFRVSAVNCAGQ 27250
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 14/135 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P K L T + + V W+ + +I Y+V++R GI + + + T
Sbjct: 23821 PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKR------RIT 23874
Query: 245 DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPA-PANLRLANSTV 303
D R+++T + Y+FRV+A N G G +P+ + + DP P P N + ++T
Sbjct: 23875 DLRLRVTGLTEDHEYEFRVSAENAAGV-GEPSPATVYYKACDPVFKPGPPTNAHIVDTTK 23933
Query: 304 NSDGSVTVTIVWDLP 318
NS +T+ W P
Sbjct: 23934 NS-----ITLAWGKP 23943
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/207 (24%), Positives = 85/207 (41%), Gaps = 36/207 (17%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P L ++ +++KW N P+ YV++++ G T W +T
Sbjct: 14186 PPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLG--------TRWVKAGKTA 14237
Query: 245 --DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
D ++TD+ QF+V A N G G + S +DP++PP+P +
Sbjct: 14238 GPDCNFRVTDVIEGTEVQFQVRAENEAGV-GHPSEPTEILSIEDPTSPPSPP----LDLH 14292
Query: 303 VNSDGSVTVTIVWDLPEE-PDIPVHHYKVFW------SWM-VSSKSLVPTKKKRRKTTDG 354
V G + I W PE+ P+ Y V WM V+S+ P K + K +G
Sbjct: 14293 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSR---PIKDLKFKVEEG 14349
Query: 355 FQNSVILEKLQPDCDYVVELQAITYWG 381
+ PD +YV+ ++A+ G
Sbjct: 14350 ---------VVPDKEYVLRVRAVNAIG 14367
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E +T W V ++ + R+++ ++ P YQFRV A N G + PS+
Sbjct: 18430 YFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV- 18488
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP PP P N R+ ++T +S +T+ W P
Sbjct: 18489 VAKDPIEPPGPPTNFRVVDTTKHS-----ITLGWGKP 18520
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 19/141 (13%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
G P P K + ++ S + VKW+ K N S P++ Y + E ++THW
Sbjct: 14901 GPPDAPDKPI-VEDVTSNSMLVKWNEPKDNGS--PIL-------GYWLEKREVNSTHWSR 14950
Query: 240 VAQTTDE--RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLR 297
V ++ + + + Y FRV A N G F+ PS +++ DP +PP P R
Sbjct: 14951 VNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP-KTAHDPISPPGPPIPR 15009
Query: 298 LANSTVNSDGSVTVTIVWDLP 318
+ +++ S T+ + W+ P
Sbjct: 15010 VTDTS-----STTIELEWEPP 15025
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA-QT 243
P +L+ +++ V W+ N V Y+V++R E D W TV +
Sbjct: 18701 PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKR--------EADRKTWSTVTPEV 18752
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
+T++ P Y FRV AVN +G T K +S S P P L + T
Sbjct: 18753 KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTK 18812
Query: 304 NSDGSVTVTIVW 315
NS T+ W
Sbjct: 18813 NS-----ATLAW 18819
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 225 YGIHPSEDDATHWQTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E A W V + T R + T + Y+ RV A+N G+ + PSK
Sbjct: 29966 YIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPI- 30024
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLPEE 320
+ DP APP P N R+ ++T S V++ W +PE+
Sbjct: 30025 VAMDPIAPPGKPQNPRVTDTTRTS-----VSLAWSVPED 30058
Score = 39.3 bits (90), Expect = 0.012
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQ---TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + D R+++T + YQFRV AVN G + + +
Sbjct: 29273 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAG-NSEPSEASN 29331
Query: 281 FRSSKDPSAPPAPANL-RLANSTVNSDGSVTVTIVWDLP 318
F S ++PS P P + R+ ++T +S +++ W P
Sbjct: 29332 FISCREPSYTPGPPSAPRVVDTTKHS-----ISLAWTKP 29365
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
TD R+++T + Y+FRVAA N G + PS +R+ D PP P +N V
Sbjct: 24957 TDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRAC-DALYPPGPP----SNPKV 25011
Query: 304 NSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+V++ W P + PV Y V
Sbjct: 25012 TDTSRSSVSLAWSKPIYDGGAPVKGYVV 25039
Score = 38.5 bits (88), Expect = 0.021
Identities = 40/147 (27%), Positives = 63/147 (42%), Gaps = 30/147 (20%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWS-SKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQ- 238
G P KP+ +RF E+++ + + W + N E Y +++R E T+W+
Sbjct: 27655 GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR--------ETSQTNWKM 27706
Query: 239 ---TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS----KHFRSSKDPSAPP 291
+VA+TT ++ ++ YQFRV A N +G S KH P P
Sbjct: 27707 VCSSVARTT---FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKP 27763
Query: 292 APANLRLANSTVNSDGSVTVTIVWDLP 318
N V SDG +++ WD P
Sbjct: 27764 VIYN-------VTSDG---MSLTWDAP 27780
Score = 37.7 bits (86), Expect = 0.035
Identities = 44/200 (22%), Positives = 74/200 (37%), Gaps = 25/200 (12%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N G K + P K +RFT + ++ + W + N P+ Y++++R
Sbjct: 28035 NASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKR-- 28092
Query: 225 YGIHPSEDDATHWQTVAQTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRS 283
E W + + + + YQFRV+AVN G G S +
Sbjct: 28093 ------ETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV-GRPLDSDPVVA 28145
Query: 284 SKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHY--------KVFWSW 334
+ P AP +N T NS +T+ W PE + + Y W
Sbjct: 28146 QIQYTVPDAPGIPEPSNITGNS-----ITLTWARPESDGGSEIQQYILERREKKSTRWVK 28200
Query: 335 MVSSKSLVPTKKKRRKTTDG 354
++S + + T+ K T+G
Sbjct: 28201 VISKRPISETRFKVTGLTEG 28220
Score = 37.0 bits (84), Expect = 0.060
Identities = 48/196 (24%), Positives = 76/196 (38%), Gaps = 20/196 (10%)
Query: 130 KQGDCPAPEKASGFAAACVESCEVDN---ECSGVKKCC-SNGCGHTCQVPKTLYKGVPLK 185
K+ D AP KA E+ N E G+ N G K L P
Sbjct: 17253 KKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGP 17312
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
PR +L +E++ + W + + YVV+RR + + W ++ T+
Sbjct: 17313 PR-DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERR--------DVASAQWSPLSATS 17363
Query: 245 DERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
++ + Y FRVAA N +G F K + + DP PP P L + V
Sbjct: 17364 KKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIK-ALDPLHPPGPPK-DLHHVDV 17421
Query: 304 NSDGSVTVTIVWDLPE 319
+ V++VW+ P+
Sbjct: 17422 D---KTEVSLVWNKPD 17434
Score = 35.4 bits (80), Expect = 0.17
Identities = 41/192 (21%), Positives = 69/192 (35%), Gaps = 31/192 (16%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P P + L + ++KW+ P+ NY + + WQTV
Sbjct: 14083 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPIT-------NYIVEKRDVRRKGWQTVDT 14135
Query: 243 TT-DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANS 301
T D + +T + Y FRVAA N G +T + + P P L + +
Sbjct: 14136 TVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDV 14195
Query: 302 TVNSDGSVTVTIVWDLPE-EPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
T V + W+ P+ + P+ Y ++ K + T+ + T G
Sbjct: 14196 TKRH-----VDLKWEPPKNDGGRPIQRY------VIEKKERLGTRWVKAGKTAG------ 14238
Query: 361 LEKLQPDCDYVV 372
PDC++ V
Sbjct: 14239 -----PDCNFRV 14245
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/203 (21%), Positives = 75/203 (36%), Gaps = 26/203 (12%)
Query: 128 LVKQGDCPAPEKASGFAAACVESCEVDNECSG----VKKCCSN--GCGHTCQVPKTLYKG 181
+V + + P A A + SC V+ G + C N G G + K
Sbjct: 19424 IVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKN 19483
Query: 182 VPLKPRKELR---FTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
P P + + + V W + P+ Y++++R E A +W
Sbjct: 19484 -PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR--------ETQAVNW 19534
Query: 238 QTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V + + ++ T ++ Y+FRV A+N G G + + ++DP PP P
Sbjct: 19535 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGP-GKPSDASKAAYARDPQYPPGPPA 19593
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
T S +V++ W P
Sbjct: 19594 FPKVYDTTRS----SVSLSWGKP 19612
Score = 35.0 bits (79), Expect = 0.23
Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 28/164 (17%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N CG K G P P L + ++Q + V W + ++ Y+++RR
Sbjct: 30211 NKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR-- 30268
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSK 279
E W T+ D RV+ T ++ + Y FRV+A N G + P K
Sbjct: 30269 ------EVPKAAWYTI----DSRVRGTSLVVKGLKENVEYHFRVSAENQF---GISKPLK 30315
Query: 280 HFRSSKDPSAPPAPANLRLANSTVNSDGSVT---VTIVWDLPEE 320
S++P P P N S VT V++ W P++
Sbjct: 30316 ----SEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD 30355
Score = 34.7 bits (78), Expect = 0.30
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 225 YGIHPSEDDATHWQTV------AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS 278
Y + + + W+ V A T ++T + YQFRV A+N G + PS
Sbjct: 16351 YWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPS 16410
Query: 279 KHFRSSKDPSAPPAPANLRLANSTVNS 305
+++DP APP P ++ + T +S
Sbjct: 16411 DP-ATARDPIAPPGPPFPKVTDWTKSS 16436
Score = 33.9 bits (76), Expect = 0.51
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDE---RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + + ++ D+ Y+FRV+A N G + PSK
Sbjct: 17044 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 17103
Query: 281 FRSSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP A P+ P N ++T NS V + W P
Sbjct: 17104 V-FAKDPIAKPSPPVNPEAIDTTCNS-----VDLTWQPP 17136
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/139 (22%), Positives = 56/139 (40%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P K T + + V W + +I Y+V+RR G W
Sbjct: 21654 PPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAG--------QRWIKCN 21705
Query: 242 QTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ T D R +++ + Y+FR+ A N G + S +++ P P N R+
Sbjct: 21706 KKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL 21765
Query: 300 NSTVNSDGSVTVTIVWDLP 318
+++ +S ++I W+ P
Sbjct: 21766 DTSRSS-----ISIAWNKP 21779
Score = 33.1 bits (74), Expect = 0.87
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 7/97 (7%)
Query: 224 NYGIHPSEDDATHWQTV--AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHF 281
NY I + + W T + D +TD+ + Y FRV A N G +A +
Sbjct: 13224 NYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 13283
Query: 282 RSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
+ + P P NL ++ T +S V + W+ P
Sbjct: 13284 KVADPIERPSPPVNLTSSDQTQSS-----VQLKWEPP 13315
Score = 33.1 bits (74), Expect = 0.87
Identities = 31/136 (22%), Positives = 56/136 (41%), Gaps = 18/136 (13%)
Query: 165 SNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRW 223
+N G + + P P ++ E+ + + + W K++ Y+V++R
Sbjct: 22223 TNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR- 22281
Query: 224 NYGIHPSEDDATHWQ----TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGF--TAP 277
+ T WQ TVA+TT ++ ++ YQFR+AA N +G + + P
Sbjct: 22282 -------DTSTTTWQIVSATVARTT---IKACRLKTGCEYQFRIAAENRYGKSTYLNSEP 22331
Query: 278 SKHFRSSKDPSAPPAP 293
+ K P P P
Sbjct: 22332 TVAQYPFKVPGPPGTP 22347
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/169 (20%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 161 KKCCSNGCG--HTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPV 215
K C N CG V + + P P + +++ + + + + W N +
Sbjct: 13560 KVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRI 13619
Query: 216 IYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFT 275
+ R G S+ + VA+T ++++T + +WY +RV A+N G +
Sbjct: 13620 KGYIVERCPRG---SDKWVACGEPVAET---KMEVTGLEEGKWYAYRVKALNRQGASKPS 13673
Query: 276 APSKHFRSSKDPSAPPAPANLR-LANSTVNSDGSVTVTIVWDLPEEPDI 323
P++ ++ AP +++ LA TV + + + EP I
Sbjct: 13674 RPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKI 13722
Score = 32.3 bits (72), Expect = 1.5
Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKF-NISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P + L T++++ + W + N E YV+ +R + W+ V T
Sbjct: 15500 PPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKR------DASRKKAEWEEVTNTA 15553
Query: 245 -DERVQLTDIRPSRWYQFRVAAVNVHG 270
++R + + P+ Y+FRV AVN +G
Sbjct: 15554 VEKRYGIWKLIPNGQYEFRVRAVNKYG 15580
Score = 32.0 bits (71), Expect = 1.9
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 10/108 (9%)
Query: 167 GCGHTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRR 222
G G VPK + PL P ++L TE+ + W + Y+ R
Sbjct: 18779 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 18838
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
E A W + D + +T ++ + Y+FRVAA N G
Sbjct: 18839 ------EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 18880
Score = 32.0 bits (71), Expect = 1.9
Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 21/131 (16%)
Query: 193 TELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT--DERVQL 250
T + + + W + P++ Y + E + WQTV++ +
Sbjct: 21268 TAVTKDSMTISWHEPLSDGGSPIL-------GYHVERKERNGILWQTVSKALVPGNIFKS 21320
Query: 251 TDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSK--DPSAPPAPANLRLANSTVNSDGS 308
+ + Y+FRV A N+ G + PS+ + DP P P N+
Sbjct: 21321 SGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNIT----------R 21370
Query: 309 VTVTIVWDLPE 319
TVT+ W PE
Sbjct: 21371 HTVTLKWAKPE 21381
Score = 31.6 bits (70), Expect = 2.5
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 24/158 (15%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ R G + V W+ + P+ Y + E+ + +W V
Sbjct: 15600 GPPGKPKVLAR----TKGSMLVSWTPPLDNGGSPIT-------GYWLEKREEGSPYWSRV 15648
Query: 241 AQTTDERVQLTDIR-------PSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAP 293
++ +V L + YQFR A+N G + PS + DP PP P
Sbjct: 15649 SRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDP-EVAGDPIFPPGP 15707
Query: 294 ANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+ S ++++ W P ++ P+ Y V
Sbjct: 15708 PSCPEVKDKTKS----SISLGWKPPAKDGGSPIKGYIV 15741
Score = 31.2 bits (69), Expect = 3.3
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P K+++ +++ ++ W P+++ V R G T+ ++
Sbjct: 14482 PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR------TYIPVMSGENK 14535
Query: 246 ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPP-APANLRLANSTVN 304
+ D+ P+ Y FRV AVN G G K+ ++DP PP P ++ + N T
Sbjct: 14536 LSWTVKDLIPNGEYFFRVKAVNKVG-GGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAE 14594
Query: 305 SDGSVTVTIVWDLP 318
+ +TI W P
Sbjct: 14595 A-----MTITWKPP 14603
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 26/145 (17%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQT 239
GVP +P K R T++ + V W + P+I Y+++R+ E ++ W
Sbjct: 19090 GVPSEP-KNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK--------ERNSLLW-- 19138
Query: 240 VAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ D V+ T+ + Y FR+ A+N G+ + P+++ + P P
Sbjct: 19139 -VKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 19197
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPE 319
+ + S TV+++W P+
Sbjct: 19198 VIDVTKS--------TVSLIWARPK 19214
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/139 (23%), Positives = 54/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P ++ T + S + + WS + YVV++R E W VA
Sbjct: 23719 PGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKR--------ETSRLAWTVVA 23770
Query: 242 -QTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
+ +++T + Y FR+ AVN +G G S P P +L + N
Sbjct: 23771 SEVVTNSLKVTKLLEGNEYVFRIMAVNKYGV-GEPLESAPVLMKNPFVLPGPPKSLEVTN 23829
Query: 301 STVNSDGSVTVTIVWDLPE 319
+S +T+ W+ P+
Sbjct: 23830 IAKDS-----MTVCWNRPD 23843
Score = 31.2 bits (69), Expect = 3.3
Identities = 28/124 (22%), Positives = 48/124 (38%), Gaps = 8/124 (6%)
Query: 163 CCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRR 222
C N G + + VP PR ++ +++ + + W+ EP +
Sbjct: 31102 CAKNRFGIDQKTVELDVADVPDPPRG-VKVSDVSRDSVNLTWT-------EPASDGGSKI 31153
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
NY + A W V Q + R + ++ YQFRV A N G + PS+
Sbjct: 31154 TNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTI 31213
Query: 283 SSKD 286
+ +D
Sbjct: 31214 TKED 31217
Score = 30.8 bits (68), Expect = 4.3
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 17/143 (11%)
Query: 179 YKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
+K P P + T++ V W+ + P+ Y ++RR G W
Sbjct: 17699 HKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTG---------KW 17749
Query: 238 QTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V +T D + ++T + Y+FRV A N+ G + S ++ + P PP P
Sbjct: 17750 VRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACR-PIKPPGPP- 17807
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
N + T +VW P
Sbjct: 17808 ---INPKLKDKSRETADLVWTKP 17827
Score = 30.8 bits (68), Expect = 4.3
Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSK-FNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV- 240
P P ++ T+ + ++WS F+ +E + Y+++ + D W V
Sbjct: 28253 PPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM--------CKADLGDWHKVN 28304
Query: 241 -AQTTDERVQLTDIRPSRWYQFRVAAVN-------------VHGTRGFTAPSKHFRSS-K 285
R +TD++ Y+FRV+A+N + TAP ++ K
Sbjct: 28305 AEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFK 28364
Query: 286 DPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE 319
A A++RL + G T T VW P+
Sbjct: 28365 QTHVVRAGASIRL---FIAYQGRPTPTAVWSKPD 28395
Score = 30.4 bits (67), Expect = 5.6
Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 8/86 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P + F ++ G + W + P++ R +Y + E WQ +++
Sbjct: 28451 PPGPITFKDVTRGSATLMWDA-------PLLDGGARIHHYVVEKREASRRSWQVISEKCT 28503
Query: 246 ERV-QLTDIRPSRWYQFRVAAVNVHG 270
++ ++ D+ Y FRV+AVN +G
Sbjct: 28504 RQIFKVNDLAEGVPYYFRVSAVNEYG 28529
Score = 30.0 bits (66), Expect = 7.3
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P L TE+ S + + W + + Y+VQ+R E W VA
Sbjct: 21555 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKR--------ETSRLAWTNVA 21606
Query: 242 QTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
++++T + Y FRV AVN +G G S+ + P P N +
Sbjct: 21607 SEVQVTKLKVTKLLKGNEYIFRVMAVNKYGV-GEPLESEPVLAVNPYGPPDPPKNPEVTT 21665
Query: 301 STVNSDGSVTVTIVWDLPE 319
T +S + + W P+
Sbjct: 21666 ITKDS-----MVVCWGHPD 21679
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Query: 217 YVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTA 276
YV+++R GI + H + + + R+++T + + Y+FRV+A N G +
Sbjct: 22771 YVLEKRDKEGIRWTR---CHKRLIGEL---RLRVTGLIENHDYEFRVSAENAAGLSEPSP 22824
Query: 277 PSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
PS ++ + DP P P N N V +V + W P
Sbjct: 22825 PSA-YQKACDPIYKPGPPN----NPKVIDITRSSVFLSWSKP 22861
Score = 30.0 bits (66), Expect = 7.3
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 3/49 (6%)
Query: 225 YGIHPSEDDATHWQTV---AQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
Y + E D W V A + + D++ + Y FRVAAVNV G
Sbjct: 29376 YVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 29424
Score = 29.6 bits (65), Expect = 9.6
Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 7/109 (6%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
+Y I + W VA+ L + + Y FRV AVN G + PS
Sbjct: 14017 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 14076
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHYKV 330
+ P P L + N T N T + W +PE + P+ +Y V
Sbjct: 14077 CREKLYPPSPPRWLEVINITKN-----TADLKWTVPEKDGGSPITNYIV 14120
Score = 29.6 bits (65), Expect = 9.6
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 249 QLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGS 308
++T + Y+FRV A+N+ G + PS+ + DP PP + N T NS
Sbjct: 20236 KVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV-VALDPIDPPGKP--EVINITRNS--- 20289
Query: 309 VTVTIVWDLPE 319
VT++W P+
Sbjct: 20290 --VTLIWTEPK 20298
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 15/162 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + + + W V + T D R ++T + + YQ+RV AVN G F+ PS+ ++
Sbjct: 20795 YFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYK 20854
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKVFWSWMVSSKS 340
++ DP PP PA +R+A+ST +S +T+ W P + V Y V +
Sbjct: 20855 AA-DPIDPPGPPAKIRIADSTKSS-----ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 20908
Query: 341 LVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQ 382
+ K +TT+ ++ L+P +Y + A+ GQ
Sbjct: 20909 TTVSTKGEVRTTE-----YVVSNLKPGVNYYFRVSAVNCAGQ 20945
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 14/135 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P K L T + + V W+ + +I Y+V++R GI + + + T
Sbjct: 17516 PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKR------RIT 17569
Query: 245 DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPA-PANLRLANSTV 303
D R+++T + Y+FRV+A N G G +P+ + + DP P P N + ++T
Sbjct: 17570 DLRLRVTGLTEDHEYEFRVSAENAAGV-GEPSPATVYYKACDPVFKPGPPTNAHIVDTTK 17628
Query: 304 NSDGSVTVTIVWDLP 318
NS +T+ W P
Sbjct: 17629 NS-----ITLAWGKP 17638
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/207 (24%), Positives = 85/207 (41%), Gaps = 36/207 (17%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P L ++ +++KW N P+ YV++++ G T W +T
Sbjct: 7881 PPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLG--------TRWVKAGKTA 7932
Query: 245 --DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
D ++TD+ QF+V A N G G + S +DP++PP+P +
Sbjct: 7933 GPDCNFRVTDVIEGTEVQFQVRAENEAGV-GHPSEPTEILSIEDPTSPPSPP----LDLH 7987
Query: 303 VNSDGSVTVTIVWDLPEE-PDIPVHHYKVFW------SWM-VSSKSLVPTKKKRRKTTDG 354
V G + I W PE+ P+ Y V WM V+S+ P K + K +G
Sbjct: 7988 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSR---PIKDLKFKVEEG 8044
Query: 355 FQNSVILEKLQPDCDYVVELQAITYWG 381
+ PD +YV+ ++A+ G
Sbjct: 8045 ---------VVPDKEYVLRVRAVNAIG 8062
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E +T W V ++ + R+++ ++ P YQFRV A N G + PS+
Sbjct: 12125 YFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV- 12183
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP PP P N R+ ++T +S +T+ W P
Sbjct: 12184 VAKDPIEPPGPPTNFRVVDTTKHS-----ITLGWGKP 12215
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 19/141 (13%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
G P P K + ++ S + VKW+ K N S P++ Y + E ++THW
Sbjct: 8596 GPPDAPDKPI-VEDVTSNSMLVKWNEPKDNGS--PIL-------GYWLEKREVNSTHWSR 8645
Query: 240 VAQTTDE--RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLR 297
V ++ + + + Y FRV A N G F+ PS +++ DP +PP P R
Sbjct: 8646 VNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP-KTAHDPISPPGPPIPR 8704
Query: 298 LANSTVNSDGSVTVTIVWDLP 318
+ +++ S T+ + W+ P
Sbjct: 8705 VTDTS-----STTIELEWEPP 8720
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA-QT 243
P +L+ +++ V W+ N V Y+V++R E D W TV +
Sbjct: 12396 PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKR--------EADRKTWSTVTPEV 12447
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
+T++ P Y FRV AVN +G T K +S S P P L + T
Sbjct: 12448 KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTK 12507
Query: 304 NSDGSVTVTIVW 315
NS T+ W
Sbjct: 12508 NS-----ATLAW 12514
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 225 YGIHPSEDDATHWQTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E A W V + T R + T + Y+ RV A+N G+ + PSK
Sbjct: 23661 YIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPI- 23719
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLPEE 320
+ DP APP P N R+ ++T S V++ W +PE+
Sbjct: 23720 VAMDPIAPPGKPQNPRVTDTTRTS-----VSLAWSVPED 23753
Score = 39.3 bits (90), Expect = 0.012
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQ---TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + D R+++T + YQFRV AVN G + + +
Sbjct: 22968 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAG-NSEPSEASN 23026
Query: 281 FRSSKDPSAPPAPANL-RLANSTVNSDGSVTVTIVWDLP 318
F S ++PS P P + R+ ++T +S +++ W P
Sbjct: 23027 FISCREPSYTPGPPSAPRVVDTTKHS-----ISLAWTKP 23060
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
TD R+++T + Y+FRVAA N G + PS +R+ D PP P +N V
Sbjct: 18652 TDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRAC-DALYPPGPP----SNPKV 18706
Query: 304 NSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+V++ W P + PV Y V
Sbjct: 18707 TDTSRSSVSLAWSKPIYDGGAPVKGYVV 18734
Score = 38.5 bits (88), Expect = 0.021
Identities = 40/147 (27%), Positives = 63/147 (42%), Gaps = 30/147 (20%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWS-SKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQ- 238
G P KP+ +RF E+++ + + W + N E Y +++R E T+W+
Sbjct: 21350 GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR--------ETSQTNWKM 21401
Query: 239 ---TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS----KHFRSSKDPSAPP 291
+VA+TT ++ ++ YQFRV A N +G S KH P P
Sbjct: 21402 VCSSVARTT---FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKP 21458
Query: 292 APANLRLANSTVNSDGSVTVTIVWDLP 318
N V SDG +++ WD P
Sbjct: 21459 VIYN-------VTSDG---MSLTWDAP 21475
Score = 37.7 bits (86), Expect = 0.035
Identities = 44/200 (22%), Positives = 74/200 (37%), Gaps = 25/200 (12%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N G K + P K +RFT + ++ + W + N P+ Y++++R
Sbjct: 21730 NASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKR-- 21787
Query: 225 YGIHPSEDDATHWQTVAQTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRS 283
E W + + + + YQFRV+AVN G G S +
Sbjct: 21788 ------ETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV-GRPLDSDPVVA 21840
Query: 284 SKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHY--------KVFWSW 334
+ P AP +N T NS +T+ W PE + + Y W
Sbjct: 21841 QIQYTVPDAPGIPEPSNITGNS-----ITLTWARPESDGGSEIQQYILERREKKSTRWVK 21895
Query: 335 MVSSKSLVPTKKKRRKTTDG 354
++S + + T+ K T+G
Sbjct: 21896 VISKRPISETRFKVTGLTEG 21915
Score = 37.0 bits (84), Expect = 0.060
Identities = 48/196 (24%), Positives = 76/196 (38%), Gaps = 20/196 (10%)
Query: 130 KQGDCPAPEKASGFAAACVESCEVDN---ECSGVKKCC-SNGCGHTCQVPKTLYKGVPLK 185
K+ D AP KA E+ N E G+ N G K L P
Sbjct: 10948 KKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGP 11007
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
PR +L +E++ + W + + YVV+RR + + W ++ T+
Sbjct: 11008 PR-DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERR--------DVASAQWSPLSATS 11058
Query: 245 DERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
++ + Y FRVAA N +G F K + + DP PP P L + V
Sbjct: 11059 KKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIK-ALDPLHPPGPPK-DLHHVDV 11116
Query: 304 NSDGSVTVTIVWDLPE 319
+ V++VW+ P+
Sbjct: 11117 D---KTEVSLVWNKPD 11129
Score = 35.4 bits (80), Expect = 0.17
Identities = 41/192 (21%), Positives = 69/192 (35%), Gaps = 31/192 (16%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P P + L + ++KW+ P+ NY + + WQTV
Sbjct: 7778 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPIT-------NYIVEKRDVRRKGWQTVDT 7830
Query: 243 TT-DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANS 301
T D + +T + Y FRVAA N G +T + + P P L + +
Sbjct: 7831 TVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDV 7890
Query: 302 TVNSDGSVTVTIVWDLPE-EPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
T V + W+ P+ + P+ Y ++ K + T+ + T G
Sbjct: 7891 TKRH-----VDLKWEPPKNDGGRPIQRY------VIEKKERLGTRWVKAGKTAG------ 7933
Query: 361 LEKLQPDCDYVV 372
PDC++ V
Sbjct: 7934 -----PDCNFRV 7940
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/203 (21%), Positives = 75/203 (36%), Gaps = 26/203 (12%)
Query: 128 LVKQGDCPAPEKASGFAAACVESCEVDNECSG----VKKCCSN--GCGHTCQVPKTLYKG 181
+V + + P A A + SC V+ G + C N G G + K
Sbjct: 13119 IVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKN 13178
Query: 182 VPLKPRKELR---FTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
P P + + + V W + P+ Y++++R E A +W
Sbjct: 13179 -PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR--------ETQAVNW 13229
Query: 238 QTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V + + ++ T ++ Y+FRV A+N G G + + ++DP PP P
Sbjct: 13230 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGP-GKPSDASKAAYARDPQYPPGPPA 13288
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
T S +V++ W P
Sbjct: 13289 FPKVYDTTRS----SVSLSWGKP 13307
Score = 35.0 bits (79), Expect = 0.23
Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 28/164 (17%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N CG K G P P L + ++Q + V W + ++ Y+++RR
Sbjct: 23906 NKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR-- 23963
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSK 279
E W T+ D RV+ T ++ + Y FRV+A N G + P K
Sbjct: 23964 ------EVPKAAWYTI----DSRVRGTSLVVKGLKENVEYHFRVSAENQF---GISKPLK 24010
Query: 280 HFRSSKDPSAPPAPANLRLANSTVNSDGSVT---VTIVWDLPEE 320
S++P P P N S VT V++ W P++
Sbjct: 24011 ----SEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD 24050
Score = 34.7 bits (78), Expect = 0.30
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 225 YGIHPSEDDATHWQTV------AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS 278
Y + + + W+ V A T ++T + YQFRV A+N G + PS
Sbjct: 10046 YWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPS 10105
Query: 279 KHFRSSKDPSAPPAPANLRLANSTVNS 305
+++DP APP P ++ + T +S
Sbjct: 10106 DP-ATARDPIAPPGPPFPKVTDWTKSS 10131
Score = 33.9 bits (76), Expect = 0.51
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDE---RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + + ++ D+ Y+FRV+A N G + PSK
Sbjct: 10739 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 10798
Query: 281 FRSSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP A P+ P N ++T NS V + W P
Sbjct: 10799 V-FAKDPIAKPSPPVNPEAIDTTCNS-----VDLTWQPP 10831
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/139 (22%), Positives = 56/139 (40%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P K T + + V W + +I Y+V+RR G W
Sbjct: 15349 PPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAG--------QRWIKCN 15400
Query: 242 QTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ T D R +++ + Y+FR+ A N G + S +++ P P N R+
Sbjct: 15401 KKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL 15460
Query: 300 NSTVNSDGSVTVTIVWDLP 318
+++ +S ++I W+ P
Sbjct: 15461 DTSRSS-----ISIAWNKP 15474
Score = 33.1 bits (74), Expect = 0.87
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 7/97 (7%)
Query: 224 NYGIHPSEDDATHWQTV--AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHF 281
NY I + + W T + D +TD+ + Y FRV A N G +A +
Sbjct: 6919 NYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6978
Query: 282 RSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
+ + P P NL ++ T +S V + W+ P
Sbjct: 6979 KVADPIERPSPPVNLTSSDQTQSS-----VQLKWEPP 7010
Score = 33.1 bits (74), Expect = 0.87
Identities = 31/136 (22%), Positives = 56/136 (41%), Gaps = 18/136 (13%)
Query: 165 SNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRW 223
+N G + + P P ++ E+ + + + W K++ Y+V++R
Sbjct: 15918 TNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR- 15976
Query: 224 NYGIHPSEDDATHWQ----TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGF--TAP 277
+ T WQ TVA+TT ++ ++ YQFR+AA N +G + + P
Sbjct: 15977 -------DTSTTTWQIVSATVARTT---IKACRLKTGCEYQFRIAAENRYGKSTYLNSEP 16026
Query: 278 SKHFRSSKDPSAPPAP 293
+ K P P P
Sbjct: 16027 TVAQYPFKVPGPPGTP 16042
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/169 (20%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 161 KKCCSNGCG--HTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPV 215
K C N CG V + + P P + +++ + + + + W N +
Sbjct: 7255 KVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRI 7314
Query: 216 IYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFT 275
+ R G S+ + VA+T ++++T + +WY +RV A+N G +
Sbjct: 7315 KGYIVERCPRG---SDKWVACGEPVAET---KMEVTGLEEGKWYAYRVKALNRQGASKPS 7368
Query: 276 APSKHFRSSKDPSAPPAPANLR-LANSTVNSDGSVTVTIVWDLPEEPDI 323
P++ ++ AP +++ LA TV + + + EP I
Sbjct: 7369 RPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKI 7417
Score = 32.3 bits (72), Expect = 1.5
Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKF-NISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P + L T++++ + W + N E YV+ +R + W+ V T
Sbjct: 9195 PPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKR------DASRKKAEWEEVTNTA 9248
Query: 245 -DERVQLTDIRPSRWYQFRVAAVNVHG 270
++R + + P+ Y+FRV AVN +G
Sbjct: 9249 VEKRYGIWKLIPNGQYEFRVRAVNKYG 9275
Score = 32.0 bits (71), Expect = 1.9
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 10/108 (9%)
Query: 167 GCGHTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRR 222
G G VPK + PL P ++L TE+ + W + Y+ R
Sbjct: 12474 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 12533
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
E A W + D + +T ++ + Y+FRVAA N G
Sbjct: 12534 ------EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12575
Score = 32.0 bits (71), Expect = 1.9
Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 21/131 (16%)
Query: 193 TELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT--DERVQL 250
T + + + W + P++ Y + E + WQTV++ +
Sbjct: 14963 TAVTKDSMTISWHEPLSDGGSPIL-------GYHVERKERNGILWQTVSKALVPGNIFKS 15015
Query: 251 TDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSK--DPSAPPAPANLRLANSTVNSDGS 308
+ + Y+FRV A N+ G + PS+ + DP P P N+
Sbjct: 15016 SGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNIT----------R 15065
Query: 309 VTVTIVWDLPE 319
TVT+ W PE
Sbjct: 15066 HTVTLKWAKPE 15076
Score = 31.6 bits (70), Expect = 2.5
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 24/158 (15%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ R G + V W+ + P+ Y + E+ + +W V
Sbjct: 9295 GPPGKPKVLAR----TKGSMLVSWTPPLDNGGSPIT-------GYWLEKREEGSPYWSRV 9343
Query: 241 AQTTDERVQLTDIR-------PSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAP 293
++ +V L + YQFR A+N G + PS + DP PP P
Sbjct: 9344 SRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDP-EVAGDPIFPPGP 9402
Query: 294 ANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+ S ++++ W P ++ P+ Y V
Sbjct: 9403 PSCPEVKDKTKS----SISLGWKPPAKDGGSPIKGYIV 9436
Score = 31.2 bits (69), Expect = 3.3
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P K+++ +++ ++ W P+++ V R G T+ ++
Sbjct: 8177 PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR------TYIPVMSGENK 8230
Query: 246 ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPP-APANLRLANSTVN 304
+ D+ P+ Y FRV AVN G G K+ ++DP PP P ++ + N T
Sbjct: 8231 LSWTVKDLIPNGEYFFRVKAVNKVG-GGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAE 8289
Query: 305 SDGSVTVTIVWDLP 318
+ +TI W P
Sbjct: 8290 A-----MTITWKPP 8298
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 26/145 (17%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQT 239
GVP +P K R T++ + V W + P+I Y+++R+ E ++ W
Sbjct: 12785 GVPSEP-KNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK--------ERNSLLW-- 12833
Query: 240 VAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ D V+ T+ + Y FR+ A+N G+ + P+++ + P P
Sbjct: 12834 -VKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 12892
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPE 319
+ + S TV+++W P+
Sbjct: 12893 VIDVTKS--------TVSLIWARPK 12909
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/139 (23%), Positives = 54/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P ++ T + S + + WS + YVV++R E W VA
Sbjct: 17414 PGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKR--------ETSRLAWTVVA 17465
Query: 242 -QTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
+ +++T + Y FR+ AVN +G G S P P +L + N
Sbjct: 17466 SEVVTNSLKVTKLLEGNEYVFRIMAVNKYGV-GEPLESAPVLMKNPFVLPGPPKSLEVTN 17524
Query: 301 STVNSDGSVTVTIVWDLPE 319
+S +T+ W+ P+
Sbjct: 17525 IAKDS-----MTVCWNRPD 17538
Score = 31.2 bits (69), Expect = 3.3
Identities = 28/124 (22%), Positives = 48/124 (38%), Gaps = 8/124 (6%)
Query: 163 CCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRR 222
C N G + + VP PR ++ +++ + + W+ EP +
Sbjct: 24797 CAKNRFGIDQKTVELDVADVPDPPRG-VKVSDVSRDSVNLTWT-------EPASDGGSKI 24848
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
NY + A W V Q + R + ++ YQFRV A N G + PS+
Sbjct: 24849 TNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTI 24908
Query: 283 SSKD 286
+ +D
Sbjct: 24909 TKED 24912
Score = 30.8 bits (68), Expect = 4.3
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 17/143 (11%)
Query: 179 YKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
+K P P + T++ V W+ + P+ Y ++RR G W
Sbjct: 11394 HKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTG---------KW 11444
Query: 238 QTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V +T D + ++T + Y+FRV A N+ G + S ++ + P PP P
Sbjct: 11445 VRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACR-PIKPPGPP- 11502
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
N + T +VW P
Sbjct: 11503 ---INPKLKDKSRETADLVWTKP 11522
Score = 30.8 bits (68), Expect = 4.3
Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSK-FNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV- 240
P P ++ T+ + ++WS F+ +E + Y+++ + D W V
Sbjct: 21948 PPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM--------CKADLGDWHKVN 21999
Query: 241 -AQTTDERVQLTDIRPSRWYQFRVAAVN-------------VHGTRGFTAPSKHFRSS-K 285
R +TD++ Y+FRV+A+N + TAP ++ K
Sbjct: 22000 AEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFK 22059
Query: 286 DPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE 319
A A++RL + G T T VW P+
Sbjct: 22060 QTHVVRAGASIRL---FIAYQGRPTPTAVWSKPD 22090
Score = 30.4 bits (67), Expect = 5.6
Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 8/86 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P + F ++ G + W + P++ R +Y + E WQ +++
Sbjct: 22146 PPGPITFKDVTRGSATLMWDA-------PLLDGGARIHHYVVEKREASRRSWQVISEKCT 22198
Query: 246 ERV-QLTDIRPSRWYQFRVAAVNVHG 270
++ ++ D+ Y FRV+AVN +G
Sbjct: 22199 RQIFKVNDLAEGVPYYFRVSAVNEYG 22224
Score = 30.0 bits (66), Expect = 7.3
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P L TE+ S + + W + + Y+VQ+R E W VA
Sbjct: 15250 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKR--------ETSRLAWTNVA 15301
Query: 242 QTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
++++T + Y FRV AVN +G G S+ + P P N +
Sbjct: 15302 SEVQVTKLKVTKLLKGNEYIFRVMAVNKYGV-GEPLESEPVLAVNPYGPPDPPKNPEVTT 15360
Query: 301 STVNSDGSVTVTIVWDLPE 319
T +S + + W P+
Sbjct: 15361 ITKDS-----MVVCWGHPD 15374
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Query: 217 YVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTA 276
YV+++R GI + H + + + R+++T + + Y+FRV+A N G +
Sbjct: 16466 YVLEKRDKEGIRWTR---CHKRLIGEL---RLRVTGLIENHDYEFRVSAENAAGLSEPSP 16519
Query: 277 PSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
PS ++ + DP P P N N V +V + W P
Sbjct: 16520 PSA-YQKACDPIYKPGPPN----NPKVIDITRSSVFLSWSKP 16556
Score = 30.0 bits (66), Expect = 7.3
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 3/49 (6%)
Query: 225 YGIHPSEDDATHWQTV---AQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
Y + E D W V A + + D++ + Y FRVAAVNV G
Sbjct: 23071 YVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 23119
Score = 29.6 bits (65), Expect = 9.6
Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 7/109 (6%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
+Y I + W VA+ L + + Y FRV AVN G + PS
Sbjct: 7712 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7771
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHYKV 330
+ P P L + N T N T + W +PE + P+ +Y V
Sbjct: 7772 CREKLYPPSPPRWLEVINITKN-----TADLKWTVPEKDGGSPITNYIV 7815
Score = 29.6 bits (65), Expect = 9.6
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 249 QLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGS 308
++T + Y+FRV A+N+ G + PS+ + DP PP + N T NS
Sbjct: 13931 KVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV-VALDPIDPPGKP--EVINITRNS--- 13984
Query: 309 VTVTIVWDLPE 319
VT++W P+
Sbjct: 13985 --VTLIWTEPK 13993
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 15/162 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + + + W V + T D R ++T + + YQ+RV AVN G F+ PS+ ++
Sbjct: 20728 YFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYK 20787
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKVFWSWMVSSKS 340
++ DP PP PA +R+A+ST +S +T+ W P + V Y V +
Sbjct: 20788 AA-DPIDPPGPPAKIRIADSTKSS-----ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 20841
Query: 341 LVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQ 382
+ K +TT+ ++ L+P +Y + A+ GQ
Sbjct: 20842 TTVSTKGEVRTTE-----YVVSNLKPGVNYYFRVSAVNCAGQ 20878
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 14/135 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P K L T + + V W+ + +I Y+V++R GI + + + T
Sbjct: 17449 PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKR------RIT 17502
Query: 245 DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPA-PANLRLANSTV 303
D R+++T + Y+FRV+A N G G +P+ + + DP P P N + ++T
Sbjct: 17503 DLRLRVTGLTEDHEYEFRVSAENAAGV-GEPSPATVYYKACDPVFKPGPPTNAHIVDTTK 17561
Query: 304 NSDGSVTVTIVWDLP 318
NS +T+ W P
Sbjct: 17562 NS-----ITLAWGKP 17571
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/207 (24%), Positives = 85/207 (41%), Gaps = 36/207 (17%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P L ++ +++KW N P+ YV++++ G T W +T
Sbjct: 7814 PPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLG--------TRWVKAGKTA 7865
Query: 245 --DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
D ++TD+ QF+V A N G G + S +DP++PP+P +
Sbjct: 7866 GPDCNFRVTDVIEGTEVQFQVRAENEAGV-GHPSEPTEILSIEDPTSPPSPP----LDLH 7920
Query: 303 VNSDGSVTVTIVWDLPEE-PDIPVHHYKVFW------SWM-VSSKSLVPTKKKRRKTTDG 354
V G + I W PE+ P+ Y V WM V+S+ P K + K +G
Sbjct: 7921 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSR---PIKDLKFKVEEG 7977
Query: 355 FQNSVILEKLQPDCDYVVELQAITYWG 381
+ PD +YV+ ++A+ G
Sbjct: 7978 ---------VVPDKEYVLRVRAVNAIG 7995
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E +T W V ++ + R+++ ++ P YQFRV A N G + PS+
Sbjct: 12058 YFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV- 12116
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP PP P N R+ ++T +S +T+ W P
Sbjct: 12117 VAKDPIEPPGPPTNFRVVDTTKHS-----ITLGWGKP 12148
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 19/141 (13%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
G P P K + ++ S + VKW+ K N S P++ Y + E ++THW
Sbjct: 8529 GPPDAPDKPI-VEDVTSNSMLVKWNEPKDNGS--PIL-------GYWLEKREVNSTHWSR 8578
Query: 240 VAQTTDE--RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLR 297
V ++ + + + Y FRV A N G F+ PS +++ DP +PP P R
Sbjct: 8579 VNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP-KTAHDPISPPGPPIPR 8637
Query: 298 LANSTVNSDGSVTVTIVWDLP 318
+ +++ S T+ + W+ P
Sbjct: 8638 VTDTS-----STTIELEWEPP 8653
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA-QT 243
P +L+ +++ V W+ N V Y+V++R E D W TV +
Sbjct: 12329 PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKR--------EADRKTWSTVTPEV 12380
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
+T++ P Y FRV AVN +G T K +S S P P L + T
Sbjct: 12381 KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTK 12440
Query: 304 NSDGSVTVTIVW 315
NS T+ W
Sbjct: 12441 NS-----ATLAW 12447
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 225 YGIHPSEDDATHWQTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E A W V + T R + T + Y+ RV A+N G+ + PSK
Sbjct: 23594 YIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPI- 23652
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLPEE 320
+ DP APP P N R+ ++T S V++ W +PE+
Sbjct: 23653 VAMDPIAPPGKPQNPRVTDTTRTS-----VSLAWSVPED 23686
Score = 39.3 bits (90), Expect = 0.012
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQ---TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + D R+++T + YQFRV AVN G + + +
Sbjct: 22901 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAG-NSEPSEASN 22959
Query: 281 FRSSKDPSAPPAPANL-RLANSTVNSDGSVTVTIVWDLP 318
F S ++PS P P + R+ ++T +S +++ W P
Sbjct: 22960 FISCREPSYTPGPPSAPRVVDTTKHS-----ISLAWTKP 22993
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
TD R+++T + Y+FRVAA N G + PS +R+ D PP P +N V
Sbjct: 18585 TDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRAC-DALYPPGPP----SNPKV 18639
Query: 304 NSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+V++ W P + PV Y V
Sbjct: 18640 TDTSRSSVSLAWSKPIYDGGAPVKGYVV 18667
Score = 38.5 bits (88), Expect = 0.021
Identities = 40/147 (27%), Positives = 63/147 (42%), Gaps = 30/147 (20%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWS-SKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQ- 238
G P KP+ +RF E+++ + + W + N E Y +++R E T+W+
Sbjct: 21283 GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR--------ETSQTNWKM 21334
Query: 239 ---TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS----KHFRSSKDPSAPP 291
+VA+TT ++ ++ YQFRV A N +G S KH P P
Sbjct: 21335 VCSSVARTT---FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKP 21391
Query: 292 APANLRLANSTVNSDGSVTVTIVWDLP 318
N V SDG +++ WD P
Sbjct: 21392 VIYN-------VTSDG---MSLTWDAP 21408
Score = 37.7 bits (86), Expect = 0.035
Identities = 44/200 (22%), Positives = 74/200 (37%), Gaps = 25/200 (12%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N G K + P K +RFT + ++ + W + N P+ Y++++R
Sbjct: 21663 NASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKR-- 21720
Query: 225 YGIHPSEDDATHWQTVAQTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRS 283
E W + + + + YQFRV+AVN G G S +
Sbjct: 21721 ------ETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV-GRPLDSDPVVA 21773
Query: 284 SKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHY--------KVFWSW 334
+ P AP +N T NS +T+ W PE + + Y W
Sbjct: 21774 QIQYTVPDAPGIPEPSNITGNS-----ITLTWARPESDGGSEIQQYILERREKKSTRWVK 21828
Query: 335 MVSSKSLVPTKKKRRKTTDG 354
++S + + T+ K T+G
Sbjct: 21829 VISKRPISETRFKVTGLTEG 21848
Score = 37.0 bits (84), Expect = 0.060
Identities = 48/196 (24%), Positives = 76/196 (38%), Gaps = 20/196 (10%)
Query: 130 KQGDCPAPEKASGFAAACVESCEVDN---ECSGVKKCC-SNGCGHTCQVPKTLYKGVPLK 185
K+ D AP KA E+ N E G+ N G K L P
Sbjct: 10881 KKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGP 10940
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
PR +L +E++ + W + + YVV+RR + + W ++ T+
Sbjct: 10941 PR-DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERR--------DVASAQWSPLSATS 10991
Query: 245 DERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
++ + Y FRVAA N +G F K + + DP PP P L + V
Sbjct: 10992 KKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIK-ALDPLHPPGPPK-DLHHVDV 11049
Query: 304 NSDGSVTVTIVWDLPE 319
+ V++VW+ P+
Sbjct: 11050 D---KTEVSLVWNKPD 11062
Score = 35.4 bits (80), Expect = 0.17
Identities = 41/192 (21%), Positives = 69/192 (35%), Gaps = 31/192 (16%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P P + L + ++KW+ P+ NY + + WQTV
Sbjct: 7711 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPIT-------NYIVEKRDVRRKGWQTVDT 7763
Query: 243 TT-DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANS 301
T D + +T + Y FRVAA N G +T + + P P L + +
Sbjct: 7764 TVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDV 7823
Query: 302 TVNSDGSVTVTIVWDLPE-EPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
T V + W+ P+ + P+ Y ++ K + T+ + T G
Sbjct: 7824 TKRH-----VDLKWEPPKNDGGRPIQRY------VIEKKERLGTRWVKAGKTAG------ 7866
Query: 361 LEKLQPDCDYVV 372
PDC++ V
Sbjct: 7867 -----PDCNFRV 7873
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/203 (21%), Positives = 75/203 (36%), Gaps = 26/203 (12%)
Query: 128 LVKQGDCPAPEKASGFAAACVESCEVDNECSG----VKKCCSN--GCGHTCQVPKTLYKG 181
+V + + P A A + SC V+ G + C N G G + K
Sbjct: 13052 IVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKN 13111
Query: 182 VPLKPRKELR---FTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
P P + + + V W + P+ Y++++R E A +W
Sbjct: 13112 -PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR--------ETQAVNW 13162
Query: 238 QTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V + + ++ T ++ Y+FRV A+N G G + + ++DP PP P
Sbjct: 13163 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGP-GKPSDASKAAYARDPQYPPGPPA 13221
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
T S +V++ W P
Sbjct: 13222 FPKVYDTTRS----SVSLSWGKP 13240
Score = 35.0 bits (79), Expect = 0.23
Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 28/164 (17%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N CG K G P P L + ++Q + V W + ++ Y+++RR
Sbjct: 23839 NKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR-- 23896
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSK 279
E W T+ D RV+ T ++ + Y FRV+A N G + P K
Sbjct: 23897 ------EVPKAAWYTI----DSRVRGTSLVVKGLKENVEYHFRVSAENQF---GISKPLK 23943
Query: 280 HFRSSKDPSAPPAPANLRLANSTVNSDGSVT---VTIVWDLPEE 320
S++P P P N S VT V++ W P++
Sbjct: 23944 ----SEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD 23983
Score = 34.7 bits (78), Expect = 0.30
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 225 YGIHPSEDDATHWQTV------AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS 278
Y + + + W+ V A T ++T + YQFRV A+N G + PS
Sbjct: 9979 YWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPS 10038
Query: 279 KHFRSSKDPSAPPAPANLRLANSTVNS 305
+++DP APP P ++ + T +S
Sbjct: 10039 DP-ATARDPIAPPGPPFPKVTDWTKSS 10064
Score = 33.9 bits (76), Expect = 0.51
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDE---RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + + ++ D+ Y+FRV+A N G + PSK
Sbjct: 10672 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 10731
Query: 281 FRSSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP A P+ P N ++T NS V + W P
Sbjct: 10732 V-FAKDPIAKPSPPVNPEAIDTTCNS-----VDLTWQPP 10764
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/139 (22%), Positives = 56/139 (40%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P K T + + V W + +I Y+V+RR G W
Sbjct: 15282 PPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAG--------QRWIKCN 15333
Query: 242 QTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ T D R +++ + Y+FR+ A N G + S +++ P P N R+
Sbjct: 15334 KKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL 15393
Query: 300 NSTVNSDGSVTVTIVWDLP 318
+++ +S ++I W+ P
Sbjct: 15394 DTSRSS-----ISIAWNKP 15407
Score = 33.1 bits (74), Expect = 0.87
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 7/97 (7%)
Query: 224 NYGIHPSEDDATHWQTV--AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHF 281
NY I + + W T + D +TD+ + Y FRV A N G +A +
Sbjct: 6852 NYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6911
Query: 282 RSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
+ + P P NL ++ T +S V + W+ P
Sbjct: 6912 KVADPIERPSPPVNLTSSDQTQSS-----VQLKWEPP 6943
Score = 33.1 bits (74), Expect = 0.87
Identities = 31/136 (22%), Positives = 56/136 (41%), Gaps = 18/136 (13%)
Query: 165 SNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRW 223
+N G + + P P ++ E+ + + + W K++ Y+V++R
Sbjct: 15851 TNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR- 15909
Query: 224 NYGIHPSEDDATHWQ----TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGF--TAP 277
+ T WQ TVA+TT ++ ++ YQFR+AA N +G + + P
Sbjct: 15910 -------DTSTTTWQIVSATVARTT---IKACRLKTGCEYQFRIAAENRYGKSTYLNSEP 15959
Query: 278 SKHFRSSKDPSAPPAP 293
+ K P P P
Sbjct: 15960 TVAQYPFKVPGPPGTP 15975
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/169 (20%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 161 KKCCSNGCG--HTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPV 215
K C N CG V + + P P + +++ + + + + W N +
Sbjct: 7188 KVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRI 7247
Query: 216 IYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFT 275
+ R G S+ + VA+T ++++T + +WY +RV A+N G +
Sbjct: 7248 KGYIVERCPRG---SDKWVACGEPVAET---KMEVTGLEEGKWYAYRVKALNRQGASKPS 7301
Query: 276 APSKHFRSSKDPSAPPAPANLR-LANSTVNSDGSVTVTIVWDLPEEPDI 323
P++ ++ AP +++ LA TV + + + EP I
Sbjct: 7302 RPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKI 7350
Score = 32.3 bits (72), Expect = 1.5
Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKF-NISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P + L T++++ + W + N E YV+ +R + W+ V T
Sbjct: 9128 PPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKR------DASRKKAEWEEVTNTA 9181
Query: 245 -DERVQLTDIRPSRWYQFRVAAVNVHG 270
++R + + P+ Y+FRV AVN +G
Sbjct: 9182 VEKRYGIWKLIPNGQYEFRVRAVNKYG 9208
Score = 32.0 bits (71), Expect = 1.9
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 10/108 (9%)
Query: 167 GCGHTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRR 222
G G VPK + PL P ++L TE+ + W + Y+ R
Sbjct: 12407 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 12466
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
E A W + D + +T ++ + Y+FRVAA N G
Sbjct: 12467 ------EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12508
Score = 32.0 bits (71), Expect = 1.9
Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 21/131 (16%)
Query: 193 TELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT--DERVQL 250
T + + + W + P++ Y + E + WQTV++ +
Sbjct: 14896 TAVTKDSMTISWHEPLSDGGSPIL-------GYHVERKERNGILWQTVSKALVPGNIFKS 14948
Query: 251 TDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSK--DPSAPPAPANLRLANSTVNSDGS 308
+ + Y+FRV A N+ G + PS+ + DP P P N+
Sbjct: 14949 SGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNIT----------R 14998
Query: 309 VTVTIVWDLPE 319
TVT+ W PE
Sbjct: 14999 HTVTLKWAKPE 15009
Score = 31.6 bits (70), Expect = 2.5
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 24/158 (15%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ R G + V W+ + P+ Y + E+ + +W V
Sbjct: 9228 GPPGKPKVLAR----TKGSMLVSWTPPLDNGGSPIT-------GYWLEKREEGSPYWSRV 9276
Query: 241 AQTTDERVQLTDIR-------PSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAP 293
++ +V L + YQFR A+N G + PS + DP PP P
Sbjct: 9277 SRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDP-EVAGDPIFPPGP 9335
Query: 294 ANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+ S ++++ W P ++ P+ Y V
Sbjct: 9336 PSCPEVKDKTKS----SISLGWKPPAKDGGSPIKGYIV 9369
Score = 31.2 bits (69), Expect = 3.3
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P K+++ +++ ++ W P+++ V R G T+ ++
Sbjct: 8110 PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR------TYIPVMSGENK 8163
Query: 246 ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPP-APANLRLANSTVN 304
+ D+ P+ Y FRV AVN G G K+ ++DP PP P ++ + N T
Sbjct: 8164 LSWTVKDLIPNGEYFFRVKAVNKVG-GGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAE 8222
Query: 305 SDGSVTVTIVWDLP 318
+ +TI W P
Sbjct: 8223 A-----MTITWKPP 8231
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 26/145 (17%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQT 239
GVP +P K R T++ + V W + P+I Y+++R+ E ++ W
Sbjct: 12718 GVPSEP-KNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK--------ERNSLLW-- 12766
Query: 240 VAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ D V+ T+ + Y FR+ A+N G+ + P+++ + P P
Sbjct: 12767 -VKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 12825
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPE 319
+ + S TV+++W P+
Sbjct: 12826 VIDVTKS--------TVSLIWARPK 12842
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/139 (23%), Positives = 54/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P ++ T + S + + WS + YVV++R E W VA
Sbjct: 17347 PGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKR--------ETSRLAWTVVA 17398
Query: 242 -QTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
+ +++T + Y FR+ AVN +G G S P P +L + N
Sbjct: 17399 SEVVTNSLKVTKLLEGNEYVFRIMAVNKYGV-GEPLESAPVLMKNPFVLPGPPKSLEVTN 17457
Query: 301 STVNSDGSVTVTIVWDLPE 319
+S +T+ W+ P+
Sbjct: 17458 IAKDS-----MTVCWNRPD 17471
Score = 31.2 bits (69), Expect = 3.3
Identities = 28/124 (22%), Positives = 48/124 (38%), Gaps = 8/124 (6%)
Query: 163 CCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRR 222
C N G + + VP PR ++ +++ + + W+ EP +
Sbjct: 24730 CAKNRFGIDQKTVELDVADVPDPPRG-VKVSDVSRDSVNLTWT-------EPASDGGSKI 24781
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
NY + A W V Q + R + ++ YQFRV A N G + PS+
Sbjct: 24782 TNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTI 24841
Query: 283 SSKD 286
+ +D
Sbjct: 24842 TKED 24845
Score = 30.8 bits (68), Expect = 4.3
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 17/143 (11%)
Query: 179 YKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
+K P P + T++ V W+ + P+ Y ++RR G W
Sbjct: 11327 HKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTG---------KW 11377
Query: 238 QTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V +T D + ++T + Y+FRV A N+ G + S ++ + P PP P
Sbjct: 11378 VRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACR-PIKPPGPP- 11435
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
N + T +VW P
Sbjct: 11436 ---INPKLKDKSRETADLVWTKP 11455
Score = 30.8 bits (68), Expect = 4.3
Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSK-FNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV- 240
P P ++ T+ + ++WS F+ +E + Y+++ + D W V
Sbjct: 21881 PPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM--------CKADLGDWHKVN 21932
Query: 241 -AQTTDERVQLTDIRPSRWYQFRVAAVN-------------VHGTRGFTAPSKHFRSS-K 285
R +TD++ Y+FRV+A+N + TAP ++ K
Sbjct: 21933 AEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFK 21992
Query: 286 DPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE 319
A A++RL + G T T VW P+
Sbjct: 21993 QTHVVRAGASIRL---FIAYQGRPTPTAVWSKPD 22023
Score = 30.4 bits (67), Expect = 5.6
Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 8/86 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P + F ++ G + W + P++ R +Y + E WQ +++
Sbjct: 22079 PPGPITFKDVTRGSATLMWDA-------PLLDGGARIHHYVVEKREASRRSWQVISEKCT 22131
Query: 246 ERV-QLTDIRPSRWYQFRVAAVNVHG 270
++ ++ D+ Y FRV+AVN +G
Sbjct: 22132 RQIFKVNDLAEGVPYYFRVSAVNEYG 22157
Score = 30.0 bits (66), Expect = 7.3
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P L TE+ S + + W + + Y+VQ+R E W VA
Sbjct: 15183 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKR--------ETSRLAWTNVA 15234
Query: 242 QTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
++++T + Y FRV AVN +G G S+ + P P N +
Sbjct: 15235 SEVQVTKLKVTKLLKGNEYIFRVMAVNKYGV-GEPLESEPVLAVNPYGPPDPPKNPEVTT 15293
Query: 301 STVNSDGSVTVTIVWDLPE 319
T +S + + W P+
Sbjct: 15294 ITKDS-----MVVCWGHPD 15307
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Query: 217 YVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTA 276
YV+++R GI + H + + + R+++T + + Y+FRV+A N G +
Sbjct: 16399 YVLEKRDKEGIRWTR---CHKRLIGEL---RLRVTGLIENHDYEFRVSAENAAGLSEPSP 16452
Query: 277 PSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
PS ++ + DP P P N N V +V + W P
Sbjct: 16453 PSA-YQKACDPIYKPGPPN----NPKVIDITRSSVFLSWSKP 16489
Score = 30.0 bits (66), Expect = 7.3
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 3/49 (6%)
Query: 225 YGIHPSEDDATHWQTV---AQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
Y + E D W V A + + D++ + Y FRVAAVNV G
Sbjct: 23004 YVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 23052
Score = 29.6 bits (65), Expect = 9.6
Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 7/109 (6%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
+Y I + W VA+ L + + Y FRV AVN G + PS
Sbjct: 7645 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7704
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHYKV 330
+ P P L + N T N T + W +PE + P+ +Y V
Sbjct: 7705 CREKLYPPSPPRWLEVINITKN-----TADLKWTVPEKDGGSPITNYIV 7748
Score = 29.6 bits (65), Expect = 9.6
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 249 QLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGS 308
++T + Y+FRV A+N+ G + PS+ + DP PP + N T NS
Sbjct: 13864 KVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV-VALDPIDPPGKP--EVINITRNS--- 13917
Query: 309 VTVTIVWDLPE 319
VT++W P+
Sbjct: 13918 --VTLIWTEPK 13926
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 15/162 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + + + W V + T D R ++T + + YQ+RV AVN G F+ PS+ ++
Sbjct: 20603 YFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYK 20662
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKVFWSWMVSSKS 340
++ DP PP PA +R+A+ST +S +T+ W P + V Y V +
Sbjct: 20663 AA-DPIDPPGPPAKIRIADSTKSS-----ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 20716
Query: 341 LVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQ 382
+ K +TT+ ++ L+P +Y + A+ GQ
Sbjct: 20717 TTVSTKGEVRTTE-----YVVSNLKPGVNYYFRVSAVNCAGQ 20753
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 14/135 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P K L T + + V W+ + +I Y+V++R GI + + + T
Sbjct: 17324 PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKR------RIT 17377
Query: 245 DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPA-PANLRLANSTV 303
D R+++T + Y+FRV+A N G G +P+ + + DP P P N + ++T
Sbjct: 17378 DLRLRVTGLTEDHEYEFRVSAENAAGV-GEPSPATVYYKACDPVFKPGPPTNAHIVDTTK 17436
Query: 304 NSDGSVTVTIVWDLP 318
NS +T+ W P
Sbjct: 17437 NS-----ITLAWGKP 17446
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/207 (24%), Positives = 85/207 (41%), Gaps = 36/207 (17%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P L ++ +++KW N P+ YV++++ G T W +T
Sbjct: 7689 PPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLG--------TRWVKAGKTA 7740
Query: 245 --DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
D ++TD+ QF+V A N G G + S +DP++PP+P +
Sbjct: 7741 GPDCNFRVTDVIEGTEVQFQVRAENEAGV-GHPSEPTEILSIEDPTSPPSPP----LDLH 7795
Query: 303 VNSDGSVTVTIVWDLPEE-PDIPVHHYKVFW------SWM-VSSKSLVPTKKKRRKTTDG 354
V G + I W PE+ P+ Y V WM V+S+ P K + K +G
Sbjct: 7796 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSR---PIKDLKFKVEEG 7852
Query: 355 FQNSVILEKLQPDCDYVVELQAITYWG 381
+ PD +YV+ ++A+ G
Sbjct: 7853 ---------VVPDKEYVLRVRAVNAIG 7870
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 225 YGIHPSEDDATHWQTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E +T W V ++ + R+++ ++ P YQFRV A N G + PS+
Sbjct: 11933 YFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV- 11991
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP PP P N R+ ++T +S +T+ W P
Sbjct: 11992 VAKDPIEPPGPPTNFRVVDTTKHS-----ITLGWGKP 12023
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 19/141 (13%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
G P P K + ++ S + VKW+ K N S P++ Y + E ++THW
Sbjct: 8404 GPPDAPDKPI-VEDVTSNSMLVKWNEPKDNGS--PIL-------GYWLEKREVNSTHWSR 8453
Query: 240 VAQTTDE--RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLR 297
V ++ + + + Y FRV A N G F+ PS +++ DP +PP P R
Sbjct: 8454 VNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP-KTAHDPISPPGPPIPR 8512
Query: 298 LANSTVNSDGSVTVTIVWDLP 318
+ +++ S T+ + W+ P
Sbjct: 8513 VTDTS-----STTIELEWEPP 8528
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA-QT 243
P +L+ +++ V W+ N V Y+V++R E D W TV +
Sbjct: 12204 PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKR--------EADRKTWSTVTPEV 12255
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
+T++ P Y FRV AVN +G T K +S S P P L + T
Sbjct: 12256 KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTK 12315
Query: 304 NSDGSVTVTIVW 315
NS T+ W
Sbjct: 12316 NS-----ATLAW 12322
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 225 YGIHPSEDDATHWQTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E A W V + T R + T + Y+ RV A+N G+ + PSK
Sbjct: 23469 YIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPI- 23527
Query: 283 SSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLPEE 320
+ DP APP P N R+ ++T S V++ W +PE+
Sbjct: 23528 VAMDPIAPPGKPQNPRVTDTTRTS-----VSLAWSVPED 23561
Score = 39.3 bits (90), Expect = 0.012
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQ---TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + D R+++T + YQFRV AVN G + + +
Sbjct: 22776 NYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAG-NSEPSEASN 22834
Query: 281 FRSSKDPSAPPAPANL-RLANSTVNSDGSVTVTIVWDLP 318
F S ++PS P P + R+ ++T +S +++ W P
Sbjct: 22835 FISCREPSYTPGPPSAPRVVDTTKHS-----ISLAWTKP 22868
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
TD R+++T + Y+FRVAA N G + PS +R+ D PP P +N V
Sbjct: 18460 TDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRAC-DALYPPGPP----SNPKV 18514
Query: 304 NSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+V++ W P + PV Y V
Sbjct: 18515 TDTSRSSVSLAWSKPIYDGGAPVKGYVV 18542
Score = 38.5 bits (88), Expect = 0.021
Identities = 40/147 (27%), Positives = 63/147 (42%), Gaps = 30/147 (20%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWS-SKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQ- 238
G P KP+ +RF E+++ + + W + N E Y +++R E T+W+
Sbjct: 21158 GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR--------ETSQTNWKM 21209
Query: 239 ---TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS----KHFRSSKDPSAPP 291
+VA+TT ++ ++ YQFRV A N +G S KH P P
Sbjct: 21210 VCSSVARTT---FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKP 21266
Query: 292 APANLRLANSTVNSDGSVTVTIVWDLP 318
N V SDG +++ WD P
Sbjct: 21267 VIYN-------VTSDG---MSLTWDAP 21283
Score = 37.7 bits (86), Expect = 0.035
Identities = 44/200 (22%), Positives = 74/200 (37%), Gaps = 25/200 (12%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N G K + P K +RFT + ++ + W + N P+ Y++++R
Sbjct: 21538 NASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKR-- 21595
Query: 225 YGIHPSEDDATHWQTVAQTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRS 283
E W + + + + YQFRV+AVN G G S +
Sbjct: 21596 ------ETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV-GRPLDSDPVVA 21648
Query: 284 SKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHY--------KVFWSW 334
+ P AP +N T NS +T+ W PE + + Y W
Sbjct: 21649 QIQYTVPDAPGIPEPSNITGNS-----ITLTWARPESDGGSEIQQYILERREKKSTRWVK 21703
Query: 335 MVSSKSLVPTKKKRRKTTDG 354
++S + + T+ K T+G
Sbjct: 21704 VISKRPISETRFKVTGLTEG 21723
Score = 37.0 bits (84), Expect = 0.060
Identities = 48/196 (24%), Positives = 76/196 (38%), Gaps = 20/196 (10%)
Query: 130 KQGDCPAPEKASGFAAACVESCEVDN---ECSGVKKCC-SNGCGHTCQVPKTLYKGVPLK 185
K+ D AP KA E+ N E G+ N G K L P
Sbjct: 10756 KKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGP 10815
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVAQTT 244
PR +L +E++ + W + + YVV+RR + + W ++ T+
Sbjct: 10816 PR-DLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERR--------DVASAQWSPLSATS 10866
Query: 245 DERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTV 303
++ + Y FRVAA N +G F K + + DP PP P L + V
Sbjct: 10867 KKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIK-ALDPLHPPGPPK-DLHHVDV 10924
Query: 304 NSDGSVTVTIVWDLPE 319
+ V++VW+ P+
Sbjct: 10925 D---KTEVSLVWNKPD 10937
Score = 35.4 bits (80), Expect = 0.17
Identities = 41/192 (21%), Positives = 69/192 (35%), Gaps = 31/192 (16%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P P + L + ++KW+ P+ NY + + WQTV
Sbjct: 7586 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPIT-------NYIVEKRDVRRKGWQTVDT 7638
Query: 243 TT-DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANS 301
T D + +T + Y FRVAA N G +T + + P P L + +
Sbjct: 7639 TVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDV 7698
Query: 302 TVNSDGSVTVTIVWDLPE-EPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVI 360
T V + W+ P+ + P+ Y ++ K + T+ + T G
Sbjct: 7699 TKRH-----VDLKWEPPKNDGGRPIQRY------VIEKKERLGTRWVKAGKTAG------ 7741
Query: 361 LEKLQPDCDYVV 372
PDC++ V
Sbjct: 7742 -----PDCNFRV 7748
Score = 35.0 bits (79), Expect = 0.23
Identities = 43/203 (21%), Positives = 75/203 (36%), Gaps = 26/203 (12%)
Query: 128 LVKQGDCPAPEKASGFAAACVESCEVDNECSG----VKKCCSN--GCGHTCQVPKTLYKG 181
+V + + P A A + SC V+ G + C N G G + K
Sbjct: 12927 IVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKN 12986
Query: 182 VPLKPRKELR---FTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
P P + + + V W + P+ Y++++R E A +W
Sbjct: 12987 -PYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR--------ETQAVNW 13037
Query: 238 QTVAQTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V + + ++ T ++ Y+FRV A+N G G + + ++DP PP P
Sbjct: 13038 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGP-GKPSDASKAAYARDPQYPPGPPA 13096
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
T S +V++ W P
Sbjct: 13097 FPKVYDTTRS----SVSLSWGKP 13115
Score = 35.0 bits (79), Expect = 0.23
Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 28/164 (17%)
Query: 166 NGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWN 224
N CG K G P P L + ++Q + V W + ++ Y+++RR
Sbjct: 23714 NKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR-- 23771
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSK 279
E W T+ D RV+ T ++ + Y FRV+A N G + P K
Sbjct: 23772 ------EVPKAAWYTI----DSRVRGTSLVVKGLKENVEYHFRVSAENQF---GISKPLK 23818
Query: 280 HFRSSKDPSAPPAPANLRLANSTVNSDGSVT---VTIVWDLPEE 320
S++P P P N S VT V++ W P++
Sbjct: 23819 ----SEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD 23858
Score = 34.7 bits (78), Expect = 0.30
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 225 YGIHPSEDDATHWQTV------AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPS 278
Y + + + W+ V A T ++T + YQFRV A+N G + PS
Sbjct: 9854 YWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPS 9913
Query: 279 KHFRSSKDPSAPPAPANLRLANSTVNS 305
+++DP APP P ++ + T +S
Sbjct: 9914 DP-ATARDPIAPPGPPFPKVTDWTKSS 9939
Score = 33.9 bits (76), Expect = 0.51
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDE---RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKH 280
NY + E + W V + + ++ D+ Y+FRV+A N G + PSK
Sbjct: 10547 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 10606
Query: 281 FRSSKDPSAPPA-PANLRLANSTVNSDGSVTVTIVWDLP 318
+KDP A P+ P N ++T NS V + W P
Sbjct: 10607 V-FAKDPIAKPSPPVNPEAIDTTCNS-----VDLTWQPP 10639
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/139 (22%), Positives = 56/139 (40%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P K T + + V W + +I Y+V+RR G W
Sbjct: 15157 PPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAG--------QRWIKCN 15208
Query: 242 QTT--DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ T D R +++ + Y+FR+ A N G + S +++ P P N R+
Sbjct: 15209 KKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL 15268
Query: 300 NSTVNSDGSVTVTIVWDLP 318
+++ +S ++I W+ P
Sbjct: 15269 DTSRSS-----ISIAWNKP 15282
Score = 33.1 bits (74), Expect = 0.87
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 7/97 (7%)
Query: 224 NYGIHPSEDDATHWQTV--AQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHF 281
NY I + + W T + D +TD+ + Y FRV A N G +A +
Sbjct: 6727 NYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6786
Query: 282 RSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
+ + P P NL ++ T +S V + W+ P
Sbjct: 6787 KVADPIERPSPPVNLTSSDQTQSS-----VQLKWEPP 6818
Score = 33.1 bits (74), Expect = 0.87
Identities = 31/136 (22%), Positives = 56/136 (41%), Gaps = 18/136 (13%)
Query: 165 SNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSS-KFNISIEPVIYVVQRRW 223
+N G + + P P ++ E+ + + + W K++ Y+V++R
Sbjct: 15726 TNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR- 15784
Query: 224 NYGIHPSEDDATHWQ----TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGF--TAP 277
+ T WQ TVA+TT ++ ++ YQFR+AA N +G + + P
Sbjct: 15785 -------DTSTTTWQIVSATVARTT---IKACRLKTGCEYQFRIAAENRYGKSTYLNSEP 15834
Query: 278 SKHFRSSKDPSAPPAP 293
+ K P P P
Sbjct: 15835 TVAQYPFKVPGPPGTP 15850
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/169 (20%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 161 KKCCSNGCG--HTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPV 215
K C N CG V + + P P + +++ + + + + W N +
Sbjct: 7063 KVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRI 7122
Query: 216 IYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFT 275
+ R G S+ + VA+T ++++T + +WY +RV A+N G +
Sbjct: 7123 KGYIVERCPRG---SDKWVACGEPVAET---KMEVTGLEEGKWYAYRVKALNRQGASKPS 7176
Query: 276 APSKHFRSSKDPSAPPAPANLR-LANSTVNSDGSVTVTIVWDLPEEPDI 323
P++ ++ AP +++ LA TV + + + EP I
Sbjct: 7177 RPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKI 7225
Score = 32.3 bits (72), Expect = 1.5
Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKF-NISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT 244
P + L T++++ + W + N E YV+ +R + W+ V T
Sbjct: 9003 PPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKR------DASRKKAEWEEVTNTA 9056
Query: 245 -DERVQLTDIRPSRWYQFRVAAVNVHG 270
++R + + P+ Y+FRV AVN +G
Sbjct: 9057 VEKRYGIWKLIPNGQYEFRVRAVNKYG 9083
Score = 32.0 bits (71), Expect = 1.9
Identities = 27/108 (25%), Positives = 41/108 (37%), Gaps = 10/108 (9%)
Query: 167 GCGHTCQVPKTLYKGVPLK---PRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRR 222
G G VPK + PL P ++L TE+ + W + Y+ R
Sbjct: 12282 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 12341
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
E A W + D + +T ++ + Y+FRVAA N G
Sbjct: 12342 ------EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12383
Score = 32.0 bits (71), Expect = 1.9
Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 21/131 (16%)
Query: 193 TELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT--DERVQL 250
T + + + W + P++ Y + E + WQTV++ +
Sbjct: 14771 TAVTKDSMTISWHEPLSDGGSPIL-------GYHVERKERNGILWQTVSKALVPGNIFKS 14823
Query: 251 TDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSK--DPSAPPAPANLRLANSTVNSDGS 308
+ + Y+FRV A N+ G + PS+ + DP P P N+
Sbjct: 14824 SGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNIT----------R 14873
Query: 309 VTVTIVWDLPE 319
TVT+ W PE
Sbjct: 14874 HTVTLKWAKPE 14884
Score = 31.6 bits (70), Expect = 2.5
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 24/158 (15%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ R G + V W+ + P+ Y + E+ + +W V
Sbjct: 9103 GPPGKPKVLAR----TKGSMLVSWTPPLDNGGSPIT-------GYWLEKREEGSPYWSRV 9151
Query: 241 AQTTDERVQLTDIR-------PSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAP 293
++ +V L + YQFR A+N G + PS + DP PP P
Sbjct: 9152 SRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDP-EVAGDPIFPPGP 9210
Query: 294 ANLRLANSTVNSDGSVTVTIVWDLP-EEPDIPVHHYKV 330
+ S ++++ W P ++ P+ Y V
Sbjct: 9211 PSCPEVKDKTKS----SISLGWKPPAKDGGSPIKGYIV 9244
Score = 31.2 bits (69), Expect = 3.3
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P K+++ +++ ++ W P+++ V R G T+ ++
Sbjct: 7985 PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR------TYIPVMSGENK 8038
Query: 246 ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPP-APANLRLANSTVN 304
+ D+ P+ Y FRV AVN G G K+ ++DP PP P ++ + N T
Sbjct: 8039 LSWTVKDLIPNGEYFFRVKAVNKVG-GGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAE 8097
Query: 305 SDGSVTVTIVWDLP 318
+ +TI W P
Sbjct: 8098 A-----MTITWKPP 8106
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 26/145 (17%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQT 239
GVP +P K R T++ + V W + P+I Y+++R+ E ++ W
Sbjct: 12593 GVPSEP-KNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK--------ERNSLLW-- 12641
Query: 240 VAQTTDERVQLTD-----IRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ D V+ T+ + Y FR+ A+N G+ + P+++ + P P
Sbjct: 12642 -VKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 12700
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPE 319
+ + S TV+++W P+
Sbjct: 12701 VIDVTKS--------TVSLIWARPK 12717
Score = 31.2 bits (69), Expect = 3.3
Identities = 32/139 (23%), Positives = 54/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P ++ T + S + + WS + YVV++R E W VA
Sbjct: 17222 PGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKR--------ETSRLAWTVVA 17273
Query: 242 -QTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
+ +++T + Y FR+ AVN +G G S P P +L + N
Sbjct: 17274 SEVVTNSLKVTKLLEGNEYVFRIMAVNKYGV-GEPLESAPVLMKNPFVLPGPPKSLEVTN 17332
Query: 301 STVNSDGSVTVTIVWDLPE 319
+S +T+ W+ P+
Sbjct: 17333 IAKDS-----MTVCWNRPD 17346
Score = 31.2 bits (69), Expect = 3.3
Identities = 28/124 (22%), Positives = 48/124 (38%), Gaps = 8/124 (6%)
Query: 163 CCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRR 222
C N G + + VP PR ++ +++ + + W+ EP +
Sbjct: 24605 CAKNRFGIDQKTVELDVADVPDPPRG-VKVSDVSRDSVNLTWT-------EPASDGGSKI 24656
Query: 223 WNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
NY + A W V Q + R + ++ YQFRV A N G + PS+
Sbjct: 24657 TNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTI 24716
Query: 283 SSKD 286
+ +D
Sbjct: 24717 TKED 24720
Score = 30.8 bits (68), Expect = 4.3
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 17/143 (11%)
Query: 179 YKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHW 237
+K P P + T++ V W+ + P+ Y ++RR G W
Sbjct: 11202 HKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTG---------KW 11252
Query: 238 QTVAQT--TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN 295
V +T D + ++T + Y+FRV A N+ G + S ++ + P PP P
Sbjct: 11253 VRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACR-PIKPPGPP- 11310
Query: 296 LRLANSTVNSDGSVTVTIVWDLP 318
N + T +VW P
Sbjct: 11311 ---INPKLKDKSRETADLVWTKP 11330
Score = 30.8 bits (68), Expect = 4.3
Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSK-FNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV- 240
P P ++ T+ + ++WS F+ +E + Y+++ + D W V
Sbjct: 21756 PPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM--------CKADLGDWHKVN 21807
Query: 241 -AQTTDERVQLTDIRPSRWYQFRVAAVN-------------VHGTRGFTAPSKHFRSS-K 285
R +TD++ Y+FRV+A+N + TAP ++ K
Sbjct: 21808 AEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFK 21867
Query: 286 DPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE 319
A A++RL + G T T VW P+
Sbjct: 21868 QTHVVRAGASIRL---FIAYQGRPTPTAVWSKPD 21898
Score = 30.4 bits (67), Expect = 5.6
Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 8/86 (9%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P + F ++ G + W + P++ R +Y + E WQ +++
Sbjct: 21954 PPGPITFKDVTRGSATLMWDA-------PLLDGGARIHHYVVEKREASRRSWQVISEKCT 22006
Query: 246 ERV-QLTDIRPSRWYQFRVAAVNVHG 270
++ ++ D+ Y FRV+AVN +G
Sbjct: 22007 RQIFKVNDLAEGVPYYFRVSAVNEYG 22032
Score = 30.0 bits (66), Expect = 7.3
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 16/139 (11%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGIHPSEDDATHWQTVA 241
P P L TE+ S + + W + + Y+VQ+R E W VA
Sbjct: 15058 PGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKR--------ETSRLAWTNVA 15109
Query: 242 QTTD-ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLAN 300
++++T + Y FRV AVN +G G S+ + P P N +
Sbjct: 15110 SEVQVTKLKVTKLLKGNEYIFRVMAVNKYGV-GEPLESEPVLAVNPYGPPDPPKNPEVTT 15168
Query: 301 STVNSDGSVTVTIVWDLPE 319
T +S + + W P+
Sbjct: 15169 ITKDS-----MVVCWGHPD 15182
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Query: 217 YVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTA 276
YV+++R GI + H + + + R+++T + + Y+FRV+A N G +
Sbjct: 16274 YVLEKRDKEGIRWTR---CHKRLIGEL---RLRVTGLIENHDYEFRVSAENAAGLSEPSP 16327
Query: 277 PSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLP 318
PS ++ + DP P P N N V +V + W P
Sbjct: 16328 PSA-YQKACDPIYKPGPPN----NPKVIDITRSSVFLSWSKP 16364
Score = 30.0 bits (66), Expect = 7.3
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 3/49 (6%)
Query: 225 YGIHPSEDDATHWQTV---AQTTDERVQLTDIRPSRWYQFRVAAVNVHG 270
Y + E D W V A + + D++ + Y FRVAAVNV G
Sbjct: 22879 YVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKG 22927
Score = 29.6 bits (65), Expect = 9.6
Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 7/109 (6%)
Query: 224 NYGIHPSEDDATHWQTVAQTTDERVQLTD-IRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
+Y I + W VA+ L + + Y FRV AVN G + PS
Sbjct: 7520 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7579
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPE-EPDIPVHHYKV 330
+ P P L + N T N T + W +PE + P+ +Y V
Sbjct: 7580 CREKLYPPSPPRWLEVINITKN-----TADLKWTVPEKDGGSPITNYIV 7623
Score = 29.6 bits (65), Expect = 9.6
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 249 QLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGS 308
++T + Y+FRV A+N+ G + PS+ + DP PP + N T NS
Sbjct: 13739 KVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV-VALDPIDPPGKP--EVINITRNS--- 13792
Query: 309 VTVTIVWDLPE 319
VT++W P+
Sbjct: 13793 --VTLIWTEPK 13801
>gi|32307109 WAP four-disulfide core domain 3 precursor [Homo
sapiens]
Length = 231
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 98 KHQCQSFCE--PLFPKKSYECLTSC-EFLKYILLVKQGDCPAPEKASGFAAACVESCEVD 154
K+ C+ C+ L P + C T C + I ++ DCP + +C++ C D
Sbjct: 37 KNPCKELCQGDELCPAEQKCCTTGCGRICRDIPKGRKRDCPRVIRKQ----SCLKRCITD 92
Query: 155 NECSGVKKCCSNGCGHTCQVP 175
C GVKKCC+ GC +C VP
Sbjct: 93 ETCPGVKKCCTLGCNKSCVVP 113
Score = 43.1 bits (100), Expect = 8e-04
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 14/85 (16%)
Query: 96 LRKHQCQSFC--EPLFPKKSYECLTSCEFLKYILLVKQ------GDCPAPEKASGFAAAC 147
+RK C C + P C C + + KQ G+CPA C
Sbjct: 80 IRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEFGGECPADP------LPC 133
Query: 148 VESCEVDNECSGVKKCCSNGCGHTC 172
E C+ D C KCCS GCG TC
Sbjct: 134 EELCDGDASCPQGHKCCSTGCGRTC 158
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/95 (29%), Positives = 39/95 (41%), Gaps = 10/95 (10%)
Query: 101 CQSFCE--PLFPKKSYECLTSC--EFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNE 156
C+ C+ P+ C T C L I + GDCP C+ C +D
Sbjct: 133 CEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKV-----LVGLCIVGCVMDEN 187
Query: 157 CSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELR 191
C +KCC +GCG C VP L + + P +R
Sbjct: 188 CQAGEKCCKSGCGRFC-VPPVLPPKLTMNPNWTVR 221
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
5 precursor [Homo sapiens]
Length = 1502
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 26/210 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
K +P P + TE + + + W S + EPV Y + + H ++ ++
Sbjct: 317 KALPKPPGTPV-VTESTATSITLTWDSG---NPEPVSYYIIQ------HKPKNSEELYKE 366
Query: 240 VAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ R + + P Y+FRV AVN G + P S + PS+ P R+
Sbjct: 367 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 426
Query: 300 NSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
+ST T+ + W PEEP+ + Y+V++ ++ PT+ +S
Sbjct: 427 SST-------TILVQWKEPEEPNGQIQGYRVYY-------TMDPTQHVNNWMKHNVADSQ 472
Query: 360 I--LEKLQPDCDYVVELQAITYWGQTRLKS 387
I + L P Y V++ A T G L S
Sbjct: 473 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 502
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 26/210 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
K +P P + TE + + + W S + EPV Y + + H ++ ++
Sbjct: 320 KALPKPPGTPV-VTESTATSITLTWDSG---NPEPVSYYIIQ------HKPKNSEELYKE 369
Query: 240 VAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ R + + P Y+FRV AVN G + P S + PS+ P R+
Sbjct: 370 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 429
Query: 300 NSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
+ST T+ + W PEEP+ + Y+V++ ++ PT+ +S
Sbjct: 430 SST-------TILVQWKEPEEPNGQIQGYRVYY-------TMDPTQHVNNWMKHNVADSQ 475
Query: 360 I--LEKLQPDCDYVVELQAITYWGQTRLKS 387
I + L P Y V++ A T G L S
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 505
Score = 31.2 bits (69), Expect = 3.3
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 9/80 (11%)
Query: 239 TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRL 298
T+ T R+Q ++P+ Y FR+AA + G TA PSAPP
Sbjct: 563 TIEPGTSYRLQ--GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP------- 613
Query: 299 ANSTVNSDGSVTVTIVWDLP 318
+ + S S ++ + W P
Sbjct: 614 QDISCTSPSSTSILVSWQPP 633
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 26/210 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
K +P P + TE + + + W S + EPV Y + + H ++ ++
Sbjct: 307 KALPKPPGTPV-VTESTATSITLTWDSG---NPEPVSYYIIQ------HKPKNSEELYKE 356
Query: 240 VAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ R + + P Y+FRV AVN G + P S + PS+ P R+
Sbjct: 357 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 416
Query: 300 NSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
+ST T+ + W PEEP+ + Y+V++ ++ PT+ +S
Sbjct: 417 SST-------TILVQWKEPEEPNGQIQGYRVYY-------TMDPTQHVNNWMKHNVADSQ 462
Query: 360 I--LEKLQPDCDYVVELQAITYWGQTRLKS 387
I + L P Y V++ A T G L S
Sbjct: 463 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 492
Score = 31.2 bits (69), Expect = 3.3
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 9/80 (11%)
Query: 239 TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRL 298
T+ T R+Q ++P+ Y FR+AA + G TA PSAPP
Sbjct: 550 TIEPGTSYRLQ--GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP------- 600
Query: 299 ANSTVNSDGSVTVTIVWDLP 318
+ + S S ++ + W P
Sbjct: 601 QDISCTSPSSTSILVSWQPP 620
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 26/210 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
K +P P + TE + + + W S + EPV Y + + H ++ ++
Sbjct: 320 KALPKPPGTPV-VTESTATSITLTWDSG---NPEPVSYYIIQ------HKPKNSEELYKE 369
Query: 240 VAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ R + + P Y+FRV AVN G + P S + PS+ P R+
Sbjct: 370 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 429
Query: 300 NSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
+ST T+ + W PEEP+ + Y+V++ ++ PT+ +S
Sbjct: 430 SST-------TILVQWKEPEEPNGQIQGYRVYY-------TMDPTQHVNNWMKHNVADSQ 475
Query: 360 I--LEKLQPDCDYVVELQAITYWGQTRLKS 387
I + L P Y V++ A T G L S
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 505
Score = 31.2 bits (69), Expect = 3.3
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 9/80 (11%)
Query: 239 TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRL 298
T+ T R+Q ++P+ Y FR+AA + G TA PSAPP
Sbjct: 563 TIEPGTSYRLQ--GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP------- 613
Query: 299 ANSTVNSDGSVTVTIVWDLP 318
+ + S S ++ + W P
Sbjct: 614 QDISCTSPSSTSILVSWQPP 633
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
4 precursor [Homo sapiens]
Length = 1501
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/210 (24%), Positives = 86/210 (40%), Gaps = 26/210 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQT 239
K +P P + TE + + + W S + EPV Y + + H ++ ++
Sbjct: 320 KALPKPPGTPV-VTESTATSITLTWDSG---NPEPVSYYIIQ------HKPKNSEELYKE 369
Query: 240 VAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLA 299
+ R + + P Y+FRV AVN G + P S + PS+ P R+
Sbjct: 370 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 429
Query: 300 NSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
+ST T+ + W PEEP+ + Y+V++ ++ PT+ +S
Sbjct: 430 SST-------TILVQWKEPEEPNGQIQGYRVYY-------TMDPTQHVNNWMKHNVADSQ 475
Query: 360 I--LEKLQPDCDYVVELQAITYWGQTRLKS 387
I + L P Y V++ A T G L S
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 505
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/204 (26%), Positives = 87/204 (42%), Gaps = 26/204 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGI-HPSEDDATHWQ 238
K +P KP +L TE + + + W S + EPV Y YGI + + +Q
Sbjct: 316 KALP-KPPIDLVVTETTATSVTLTWDSG---NSEPVTY-------YGIQYRAAGTEGPFQ 364
Query: 239 TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKD-PSAPPAPANLR 297
V R + + P Y FRV AVN G RG + + R+ + PS+PP R
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIG-RGPPSEAVRARTGEQAPSSPPRRVQAR 423
Query: 298 LANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQN 357
+ +++ T+ + W+ PEEP+ V Y+V+++ P + T G
Sbjct: 424 MLSAS-------TMLVQWEPPEEPNGLVRGYRVYYT---PDSRRPPNAWHKHNTDAGLLT 473
Query: 358 SVILEKLQPDCDYVVELQAITYWG 381
+V L P Y + + A T G
Sbjct: 474 TV--GSLLPGITYSLRVLAFTAVG 495
Score = 33.9 bits (76), Expect = 0.51
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 9/88 (10%)
Query: 231 EDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAP 290
++D H T T+ L D++P Y+F++AA + G FT + + PSAP
Sbjct: 552 DEDQQHKVTFDPTSS--YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP 609
Query: 291 PAPANLRLANSTVNSDGSVTVTIVWDLP 318
P S GS TV + W P
Sbjct: 610 PQKV-------MCVSMGSTTVRVSWVPP 630
Score = 33.9 bits (76), Expect = 0.51
Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 9/123 (7%)
Query: 529 KSHKPVGCLGEAGHVLSKVLAK-PENLSASFIVQDVNITG-HFSWKM-AKANLYQPMTGF 585
++H VG E+ VL + P V+ +N T H WK+ + + + G+
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744
Query: 586 QVTWAEVTTESRQNSLP---NSIISQSQILP--SDHYVLTVPNLRPSTLYRLEVQVLTPG 640
QVT+ + LP + +++++Q P S+ Y T+ L P T Y + V T
Sbjct: 745 QVTYVRLEN-GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTK 803
Query: 641 GEG 643
G+G
Sbjct: 804 GDG 806
Score = 32.3 bits (72), Expect = 1.5
Identities = 35/131 (26%), Positives = 52/131 (39%), Gaps = 28/131 (21%)
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
TTD R LT ++P Y +V A G+ G +PS +S P N R+A +
Sbjct: 968 TTDTRFTLTGLKPDTTYDIKVRAWTSKGS-GPLSPS--IQSRTMPVEQVFAKNFRVAAAM 1024
Query: 303 VNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTK---KKRRKTTDGFQNSV 359
S V + W++P+ S KS VP K + DG
Sbjct: 1025 KTS-----VLLSWEVPD-----------------SYKSAVPFKILYNGQSVEVDGHSMRK 1062
Query: 360 ILEKLQPDCDY 370
++ LQP+ +Y
Sbjct: 1063 LIADLQPNTEY 1073
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/204 (26%), Positives = 87/204 (42%), Gaps = 26/204 (12%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGI-HPSEDDATHWQ 238
K +P KP +L TE + + + W S + EPV Y YGI + + +Q
Sbjct: 316 KALP-KPPIDLVVTETTATSVTLTWDSG---NSEPVTY-------YGIQYRAAGTEGPFQ 364
Query: 239 TVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKD-PSAPPAPANLR 297
V R + + P Y FRV AVN G RG + + R+ + PS+PP R
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIG-RGPPSEAVRARTGEQAPSSPPRRVQAR 423
Query: 298 LANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQN 357
+ +++ T+ + W+ PEEP+ V Y+V+++ P + T G
Sbjct: 424 MLSAS-------TMLVQWEPPEEPNGLVRGYRVYYT---PDSRRPPNAWHKHNTDAGLLT 473
Query: 358 SVILEKLQPDCDYVVELQAITYWG 381
+V L P Y + + A T G
Sbjct: 474 TV--GSLLPGITYSLRVLAFTAVG 495
Score = 33.9 bits (76), Expect = 0.51
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 9/88 (10%)
Query: 231 EDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAP 290
++D H T T+ L D++P Y+F++AA + G FT + + PSAP
Sbjct: 552 DEDQQHKVTFDPTSS--YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAP 609
Query: 291 PAPANLRLANSTVNSDGSVTVTIVWDLP 318
P S GS TV + W P
Sbjct: 610 PQKV-------MCVSMGSTTVRVSWVPP 630
Score = 32.7 bits (73), Expect = 1.1
Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 529 KSHKPVGCLGEAGHVLSKVLAK-PENLSASFIVQDVNITG-HFSWKM-AKANLYQPMTGF 585
++H VG E+ VL + P V+ +N T H WK+ + + + G+
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744
Query: 586 QVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEG 643
QVT+ + +N P + ++ ++ T+ L P T Y + V T G+G
Sbjct: 745 QVTYVRL-----ENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797
Score = 32.3 bits (72), Expect = 1.5
Identities = 35/131 (26%), Positives = 52/131 (39%), Gaps = 28/131 (21%)
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
TTD R LT ++P Y +V A G+ G +PS +S P N R+A +
Sbjct: 959 TTDTRFTLTGLKPDTTYDIKVRAWTSKGS-GPLSPS--IQSRTMPVEQVFAKNFRVAAAM 1015
Query: 303 VNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTK---KKRRKTTDGFQNSV 359
S V + W++P+ S KS VP K + DG
Sbjct: 1016 KTS-----VLLSWEVPD-----------------SYKSAVPFKILYNGQSVEVDGHSMRK 1053
Query: 360 ILEKLQPDCDY 370
++ LQP+ +Y
Sbjct: 1054 LIADLQPNTEY 1064
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 16/154 (10%)
Query: 229 PSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPS 288
P E + + T V ++D+ P Y F V A N G G S+ FR++
Sbjct: 378 PCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARN--GVSGLVT-SRSFRTASVSI 434
Query: 289 APPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKR 348
P +RL + S +++ W +P P +V W + V+ + +
Sbjct: 435 NQTEPPKVRLEGRSTTS-----LSVSWSIP-----PPQQSRV-WKYEVTYRKKGDSNSYN 483
Query: 349 RKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQ 382
+ T+GF SV L+ L PD Y+V++QA+T GQ
Sbjct: 484 VRRTEGF--SVTLDDLAPDTTYLVQVQALTQEGQ 515
>gi|56699495 WAP four-disulfide core domain 2 precursor [Homo
sapiens]
Length = 124
Score = 45.8 bits (107), Expect = 1e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 1/61 (1%)
Query: 116 CLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGH-TCQV 174
C C + K+G CP C + C+VD++C G KCC NGCG +C
Sbjct: 62 CSAGCATFCSLPNDKEGSCPQVNINFPQLGLCRDQCQVDSQCPGQMKCCRNGCGKVSCVT 121
Query: 175 P 175
P
Sbjct: 122 P 122
Score = 38.5 bits (88), Expect = 0.021
Identities = 17/46 (36%), Positives = 22/46 (47%), Gaps = 4/46 (8%)
Query: 130 KQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVP 175
K G CP + C + C D+EC+ KCCS GC C +P
Sbjct: 32 KTGVCPELQADQN----CTQECVSDSECADNLKCCSAGCATFCSLP 73
>gi|153946389 WAP four-disulfide core domain 8 precursor [Homo
sapiens]
Length = 241
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
Query: 77 CQNHKQC------SKCLEPCKESGDL--RKHQCQSFCEPL-FPKKSYECLT----SCE-- 121
C+ +++C KC++P +E L R C + F K+Y C CE
Sbjct: 72 CKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGN 131
Query: 122 ---FLKY-------ILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHT 171
FL +L+VK G CP C SC D +C KCC + CG
Sbjct: 132 ANNFLNEDACRTACMLIVKDGQCPLFPFTE--RKECPPSCHSDIDCPQTDKCCESRCGFV 189
Query: 172 CQVPKTLYKGVPLKPRKELRFTEL 195
C T+ KG PRK L T++
Sbjct: 190 CARAWTVKKG--FCPRKPLLCTKI 211
Score = 32.3 bits (72), Expect = 1.5
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 110 PKKSYECLTSCEFL-KYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGC 168
P+ C + C F+ VK+G CP K C D EC V+KCCS+ C
Sbjct: 176 PQTDKCCESRCGFVCARAWTVKKGFCP--RKPLLCTKIDKPKCLQDEECPLVEKCCSH-C 232
Query: 169 GHTCQVPK 176
G C P+
Sbjct: 233 GLKCMDPR 240
>gi|153946387 WAP four-disulfide core domain 8 precursor [Homo
sapiens]
Length = 241
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
Query: 77 CQNHKQC------SKCLEPCKESGDL--RKHQCQSFCEPL-FPKKSYECLT----SCE-- 121
C+ +++C KC++P +E L R C + F K+Y C CE
Sbjct: 72 CKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGN 131
Query: 122 ---FLKY-------ILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHT 171
FL +L+VK G CP C SC D +C KCC + CG
Sbjct: 132 ANNFLNEDACRTACMLIVKDGQCPLFPFTE--RKECPPSCHSDIDCPQTDKCCESRCGFV 189
Query: 172 CQVPKTLYKGVPLKPRKELRFTEL 195
C T+ KG PRK L T++
Sbjct: 190 CARAWTVKKG--FCPRKPLLCTKI 211
Score = 32.3 bits (72), Expect = 1.5
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 110 PKKSYECLTSCEFL-KYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGC 168
P+ C + C F+ VK+G CP K C D EC V+KCCS+ C
Sbjct: 176 PQTDKCCESRCGFVCARAWTVKKGFCP--RKPLLCTKIDKPKCLQDEECPLVEKCCSH-C 232
Query: 169 GHTCQVPK 176
G C P+
Sbjct: 233 GLKCMDPR 240
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 43.9 bits (102), Expect = 5e-04
Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 15/139 (10%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVN-VHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
T+ RV ++ + Y F V AVN V G + + +AP LRL +S+
Sbjct: 406 TERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSS 465
Query: 303 VNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILE 362
+S +T+ W PE P+ + Y++ + S+ + T + NSV L+
Sbjct: 466 GSS-----LTLSWAPPERPNGVILDYEM--KYFEKSEGIASTVTSQ-------MNSVQLD 511
Query: 363 KLQPDCDYVVELQAITYWG 381
L+PD YVV+++A T G
Sbjct: 512 GLRPDARYVVQVRARTVAG 530
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 17/142 (11%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKD-PSAPPAPANLRLANST 302
T+ L +++ Y+ +V + +G + SK R++++ PSAPP + T
Sbjct: 709 TERSAVLVNLKKGVTYEIKVRPY-FNEFQGMDSESKTVRTTEEAPSAPPQSVTVL----T 763
Query: 303 VNSDGSVTVTIVWDLPEEPDIP---VHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
V S S ++++ WD P PD + YK+ W + ++ T+ KT D SV
Sbjct: 764 VGSYNSTSISVSWD-PPPPDHQNGIIQEYKI---WCLGNE----TRFHINKTVDAAIRSV 815
Query: 360 ILEKLQPDCDYVVELQAITYWG 381
I+ L P Y VE+ A T G
Sbjct: 816 IIGGLFPGIQYRVEVAASTSAG 837
Score = 30.8 bits (68), Expect = 4.3
Identities = 36/165 (21%), Positives = 65/165 (39%), Gaps = 28/165 (16%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ T++ + + W ++ Y+++ S+ + WQTV
Sbjct: 539 GPPSKPQ----VTDVTKNSVTLSWQPGTPGTLPASAYIIEAF-------SQSVSNSWQTV 587
Query: 241 AQTTDERVQ-LTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN---- 295
A + + +RP+ Y F V A+N G + S R ++D S P +
Sbjct: 588 ANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVR-TQDISPPAQGVDHRQV 646
Query: 296 --------LRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFW 332
+RL N V + TV + W + +P + Y+V +
Sbjct: 647 QKELGDVLVRLHNPVVLT--PTTVQVTWTVDRQPQF-IQGYRVMY 688
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 17/142 (11%)
Query: 244 TDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKD-PSAPPAPANLRLANST 302
T+ L +++ Y+ +V + +G + SK R++++ PSAPP + T
Sbjct: 693 TERSAVLVNLKKGVTYEIKVRPY-FNEFQGMDSESKTVRTTEEAPSAPPQSVTVL----T 747
Query: 303 VNSDGSVTVTIVWDLPEEPDIP---VHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSV 359
V S S ++++ WD P PD + YK+ W + ++ T+ KT D SV
Sbjct: 748 VGSYNSTSISVSWD-PPPPDHQNGIIQEYKI---WCLGNE----TRFHINKTVDAAIRSV 799
Query: 360 ILEKLQPDCDYVVELQAITYWG 381
I+ L P Y VE+ A T G
Sbjct: 800 IIGGLFPGIQYRVEVAASTSAG 821
Score = 30.8 bits (68), Expect = 4.3
Identities = 36/165 (21%), Positives = 65/165 (39%), Gaps = 28/165 (16%)
Query: 181 GVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV 240
G P KP+ T++ + + W ++ Y+++ S+ + WQTV
Sbjct: 523 GPPSKPQ----VTDVTKNSVTLSWQPGTPGTLPASAYIIEAF-------SQSVSNSWQTV 571
Query: 241 AQTTDERVQ-LTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPAN---- 295
A + + +RP+ Y F V A+N G + S R ++D S P +
Sbjct: 572 ANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVR-TQDISPPAQGVDHRQV 630
Query: 296 --------LRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFW 332
+RL N V + TV + W + +P + Y+V +
Sbjct: 631 QKELGDVLVRLHNPVVLT--PTTVQVTWTVDRQPQF-IQGYRVMY 672
>gi|156104903 myomesin 2 [Homo sapiens]
Length = 1465
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/87 (31%), Positives = 43/87 (49%), Gaps = 9/87 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTT- 244
P +L F E++ L + W + PV Y + E+DA W TV QTT
Sbjct: 815 PAYDLTFCEVRDTSLVMLWKAPVYSGSSPVS-------GYFVDFREEDAGEWITVNQTTT 867
Query: 245 -DERVQLTDIRPSRWYQFRVAAVNVHG 270
+ ++++D++ + Y FRV AVN +G
Sbjct: 868 ANRYLKVSDLQQGKTYVFRVRAVNANG 894
Score = 35.4 bits (80), Expect = 0.17
Identities = 31/146 (21%), Positives = 59/146 (40%), Gaps = 16/146 (10%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTV-AQTT 244
P + +E+ + + W +P++Y +++ S + WQ V AQT
Sbjct: 513 PPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEK--------SVVGSGSWQRVNAQTA 564
Query: 245 --DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
R + D+ + Y FRV + N HG + + ++ P AP + + +T
Sbjct: 565 VRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNT 624
Query: 303 VNSDGSVTVTIVWDLPEEPDIPVHHY 328
S V + WD P+ + + +Y
Sbjct: 625 KTS-----VVVQWDRPKHEEDLLGYY 645
Score = 32.0 bits (71), Expect = 1.9
Identities = 20/72 (27%), Positives = 32/72 (44%), Gaps = 2/72 (2%)
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLT--DIRPSRWYQFRVAAVNVHGTRGFTAPSKHFR 282
Y + E +W V + + LT + Y+F++AAVN+ G + PS+HF+
Sbjct: 745 YYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFK 804
Query: 283 SSKDPSAPPAPA 294
P PA
Sbjct: 805 CEAWTMPEPGPA 816
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/216 (20%), Positives = 88/216 (40%), Gaps = 17/216 (7%)
Query: 205 SSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVA 264
SS + +P Y + +Y I+ E D + T D +T ++ Y+ RVA
Sbjct: 582 SSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQIT-TIDNSFLITGLKKYTKYKMRVA 640
Query: 265 AVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIP 324
A G + + F + + +P ++ + + T + + + W PE+P+
Sbjct: 641 ASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE-----IRLKWSPPEKPNGI 695
Query: 325 VHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTR 384
+ Y+V + K++ K TTD +IL L+P Y + +++ T +G
Sbjct: 696 IIAYEVLY------KNIDTLYMKNTSTTD-----IILRNLRPHTLYNISVRSYTRFGHGN 744
Query: 385 LKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPF 420
S+ +S+ + T + E + + +L F
Sbjct: 745 QVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
Score = 39.3 bits (90), Expect = 0.012
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 248 VQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDG 307
V LT++ P Y+ +VAA N G F+ P F SAP NL TV +
Sbjct: 116 VLLTNLNPGTTYEIKVAAENSAGIGVFSDP---FLFQTAESAPGKVVNL-----TVEAYN 167
Query: 308 SVTVTIVWDLPEEPDIPVHHYKV 330
+ V ++W LP +P+ + +K+
Sbjct: 168 ASAVKLIWYLPRQPNGKITSFKI 190
Score = 38.1 bits (87), Expect = 0.027
Identities = 42/161 (26%), Positives = 61/161 (37%), Gaps = 21/161 (13%)
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANST 302
T D + T++ P Y +AA GT P + P P A +L+LA
Sbjct: 354 TKDLKFAFTNLTPFTMYDVYIAAETSAGT----GPKSNISVFTPPDVPGAVFDLQLAEVE 409
Query: 303 VNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVP-TKKKRRKTTDGFQNSVIL 361
S V I W P +P+ ++ Y+V K LVP T T N I
Sbjct: 410 -----STQVRITWKKPRQPNGIINQYRV--------KVLVPETGIILENTLLTGNNEYIN 456
Query: 362 EKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNN 402
+ + P+ +VE Y G + S LH +T N+
Sbjct: 457 DPMAPEIVNIVEPMVGLYEGSAEMSS---DLHSLATFIYNS 494
Score = 36.2 bits (82), Expect = 0.10
Identities = 49/227 (21%), Positives = 91/227 (40%), Gaps = 31/227 (13%)
Query: 169 GHTCQVPKTLY----KGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWN 224
GH QV L + VP + + + + SG++E+ + + + ++Q+
Sbjct: 741 GHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPN-----GIIQK--- 792
Query: 225 YGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSS 284
Y I+ + +T+ TT + ++ Y V+A + G +AP
Sbjct: 793 YTIYLKRSNGNEERTI-NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEE 851
Query: 285 KDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPT 344
P +PP + +V VTV + W P EP+ + +Y V+ W SS
Sbjct: 852 DAPDSPPQ-------DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVY-VWNRSS------ 897
Query: 345 KKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVS 391
KT + + S+ L L + +Y + A T +G + +S +S
Sbjct: 898 ----LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIIS 940
Score = 32.0 bits (71), Expect = 1.9
Identities = 82/401 (20%), Positives = 138/401 (34%), Gaps = 94/401 (23%)
Query: 180 KGVPLKPRKELRFTELQSGQLEVKWS--SKFNISIEPVIYVVQRR-------WNYGIHPS 230
+G P P K++ + L S + + W+ SK N I+ Y V R N+ +H
Sbjct: 945 EGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQ--YYSVYYRNTSGTFMQNFTLHEV 1002
Query: 231 EDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAP 290
+D + TV+ D+ + +Y F + A G ++ + +D
Sbjct: 1003 TNDFDN-MTVSTIIDKLTIFS------YYTFWLTASTSVGNGNKSSDIIEVYTDQD---- 1051
Query: 291 PAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRK 350
P + N T S S + + W P +P+ V +Y S L T + R
Sbjct: 1052 -IPEGF-VGNLTYESISSTAINVSWVPPAQPNGLVFYY--------VSLILQQTPRHVRP 1101
Query: 351 TTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTR 410
++ S+ + L+ DY++++ T G + +A+ L+ + ++ T
Sbjct: 1102 PLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQ--LYIKTEEDVPETSPIINTF 1159
Query: 411 KGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHN 470
K T + P +P GA D LQ
Sbjct: 1160 KNLSSTSVLLSWDPPVKP--NGAIISYDLTLQ---------------------------- 1189
Query: 471 RTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKS 530
+E S +T +NYIIL++LS Y K + +FF T
Sbjct: 1190 --GPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDE-------- 1239
Query: 531 HKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSW 571
S LA P+NL+ +N T F W
Sbjct: 1240 --------------SVPLAPPQNLTL------INCTSDFVW 1260
Score = 30.4 bits (67), Expect = 5.6
Identities = 19/93 (20%), Positives = 45/93 (48%), Gaps = 11/93 (11%)
Query: 293 PANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTT 352
P+++++ N + S ++ + WD PE P+ + HY ++ + ++++ T
Sbjct: 569 PSSIKIIN--YKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITT------- 619
Query: 353 DGFQNSVILEKLQPDCDYVVELQAITYWGQTRL 385
NS ++ L+ Y + + A T+ G++ L
Sbjct: 620 --IDNSFLITGLKKYTKYKMRVAASTHVGESSL 650
Score = 30.4 bits (67), Expect = 5.6
Identities = 27/93 (29%), Positives = 40/93 (43%), Gaps = 12/93 (12%)
Query: 580 QPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPN----------LRPSTL 629
Q + VT E+ + PN II ++L + L + N LRP TL
Sbjct: 670 QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTL 729
Query: 630 YRLEVQVLTPGGEG--PATIKTFRTPELPPSSA 660
Y + V+ T G G +++ + RT E P SA
Sbjct: 730 YNISVRSYTRFGHGNQVSSLLSVRTSETVPDSA 762
Score = 30.0 bits (66), Expect = 7.3
Identities = 39/140 (27%), Positives = 52/140 (37%), Gaps = 17/140 (12%)
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA-NLRLANS 301
T+D + L ++ P Y F AA TR PS D S P AP NL L N
Sbjct: 1199 TSDNYIILEELSPFTLYSFFAAA----RTRKGLGPSSILFFYTDESVPLAPPQNLTLINC 1254
Query: 302 TVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVIL 361
T + VW +P KV+ S+ + T K GF+ L
Sbjct: 1255 TSD--------FVWLKWSPSPLPGGIVKVY-SFKIHEHE---TDTIYYKNISGFKTEAKL 1302
Query: 362 EKLQPDCDYVVELQAITYWG 381
L+P Y + + A T G
Sbjct: 1303 VGLEPVSTYSIRVSAFTKVG 1322
Score = 29.6 bits (65), Expect = 9.6
Identities = 15/39 (38%), Positives = 21/39 (53%)
Query: 621 VPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSS 659
+ L P T + + V T GEGP T+ + RT + PSS
Sbjct: 533 IRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSS 571
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 41.6 bits (96), Expect = 0.002
Identities = 40/181 (22%), Positives = 81/181 (44%), Gaps = 23/181 (12%)
Query: 200 LEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIR---PS 256
+ + W+ F+ + + Y+++ SE++A W + + D + ++ P+
Sbjct: 608 INLTWTKPFDGNSPLIRYILEM--------SENNAP-WTVLLASVDPKATSVTVKGLVPA 658
Query: 257 RWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWD 316
R YQFR+ AVN G F+ ++ ++P P AP +A+ N ++ I W
Sbjct: 659 RSYQFRLCAVNDVGKGQFSKDTERVSLPEEP--PTAPPQNVIASGRTNQ----SIMIQWQ 712
Query: 317 LPEEPDIPVHHYKVFWSWMVS-SKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQ 375
P E H + +++ + +P + + TD N+++LE L +Y +E+
Sbjct: 713 PPPES----HQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
Query: 376 A 376
A
Sbjct: 769 A 769
Score = 37.0 bits (84), Expect = 0.060
Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 37/198 (18%)
Query: 233 DATHWQTVAQTTDE----RVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPS 288
+ W + Q ++E +++ D+ P Y FR+ VN+ GT + PS+ R +
Sbjct: 1037 EGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGT---SPPSQPSRKIQTLQ 1093
Query: 289 APP--APANLRLANSTVNSDGSVTVTIVW-DLPE-----EPDIPVHHYKVFWSWMVSSKS 340
APP APAN+ L ++ S + + W LPE P+ + K S+S
Sbjct: 1094 APPDMAPANVSLRTASETS-----LWLRWMPLPEMEYNGNPESVGYKIKY-------SRS 1141
Query: 341 LVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITY-----WGQTRLKSAKVSLHFT 395
K D + +E L+ +Y V++QA W QT + + S+ +
Sbjct: 1142 DGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSS 1201
Query: 396 -----STHATNNKEQLVK 408
S AT + LV+
Sbjct: 1202 GPTNVSALATTSSSMLVR 1219
Score = 31.2 bits (69), Expect = 3.3
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 12/78 (15%)
Query: 582 MTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGG 641
+TG++++W E +R N+ + LP+ V L T Y +EV +T G
Sbjct: 925 LTGYRISWEEY---NRTNT------RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG 975
Query: 642 EGPATIKTFRT---PELP 656
+G + T + PELP
Sbjct: 976 QGQVSASTISSGVPPELP 993
Score = 30.8 bits (68), Expect = 4.3
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 8/88 (9%)
Query: 245 DERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVN 304
+ V+L ++ Y VAA N G + P+ + +AP AP++++ + T
Sbjct: 1682 ENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPT---QGQTQQAAPSAPSSVKFSELTTT 1738
Query: 305 SDGSVTVTIVWDLPEEPDIPVHHYKVFW 332
S V + W+ P+ P+ + Y++ +
Sbjct: 1739 S-----VNVSWEAPQFPNGILEGYRLVY 1761
>gi|93141049 collagen, type XII, alpha 1 short isoform precursor
[Homo sapiens]
Length = 1899
Score = 41.6 bits (96), Expect = 0.002
Identities = 53/210 (25%), Positives = 83/210 (39%), Gaps = 35/210 (16%)
Query: 169 GHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGI 227
G T +TL +G+ + ++ L+V+W + PV+ Y V G
Sbjct: 759 GRTSDTGRTLMRGLA----RNVQVYNPTPNSLDVRWDP----APGPVLQYRVVYSPVDGT 810
Query: 228 HPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDP 287
PSE V V L + P Y + A+ G G +P++ +
Sbjct: 811 RPSES------IVVPGNTRMVHLERLIPDTLYSVNLVALYSDG-EGNPSPAQGRTLPRS- 862
Query: 288 SAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKK 347
P NLR+ T NS +++ WD D PV Y++ +S V T
Sbjct: 863 ----GPRNLRVFGETTNS-----LSVAWD---HADGPVQQYRIIYSPTVGDPIDEYT--- 907
Query: 348 RRKTTDGFQNSVILEKLQPDCDYVVELQAI 377
T G +N+VIL+ LQPD Y + + A+
Sbjct: 908 ---TVPGRRNNVILQPLQPDTPYKITVIAV 934
Score = 38.1 bits (87), Expect = 0.027
Identities = 76/356 (21%), Positives = 125/356 (35%), Gaps = 103/356 (28%)
Query: 293 PANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTT 352
P NL++ N+T NS +T+ WD V Y++ + + ++ T
Sbjct: 592 PRNLQVYNATSNS-----LTVKWDPASGR---VQKYRITYQPSTGEGN------EQTTTI 637
Query: 353 DGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKG 412
G QNSV+L+KL+PD Y + + ++ G+ G
Sbjct: 638 GGRQNSVVLQKLKPDTPYTITVSSLYPDGE-----------------------------G 668
Query: 413 GIQTQLPFQRRRPTRPLEV--GAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHN 470
G T R T+PL Y + V W E +Y + + P A
Sbjct: 669 GRMT-----GRGKTKPLNTVRNLRVYDPSTSTLNVRWDHAEG-NPRQYKLFYAPAAGGPE 722
Query: 471 RTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKS 530
++ NY IL++L Y VTV P+ +
Sbjct: 723 ELVPIPGNT-----NYAILRNLQPDTSYTVTVVPVYTEGDG------------------- 758
Query: 531 HKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGH---FSWKMAKANLYQPMTGFQV 587
G + G L + LA+ VQ N T + W A P+ ++V
Sbjct: 759 ----GRTSDTGRTLMRGLARN--------VQVYNPTPNSLDVRWDPAPG----PVLQYRV 802
Query: 588 TWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEG 643
++ V + P S+S ++P + ++ + L P TLY + + L GEG
Sbjct: 803 VYSPV-----DGTRP----SESIVVPGNTRMVHLERLIPDTLYSVNLVALYSDGEG 849
Score = 36.2 bits (82), Expect = 0.10
Identities = 89/418 (21%), Positives = 153/418 (36%), Gaps = 82/418 (19%)
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLV 342
S K P AP+NL ++ T S + W P + V YKV + + VS
Sbjct: 214 SVKGPGDLEAPSNLVISERTHRS-----FRVSWTPPSDS---VDRYKVEY-YPVSGG--- 261
Query: 343 PTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAIT--------YWGQTRLKSAKVSLHF 394
K++ + S +L+ L+P+ +YVV + ++ + L VSL+
Sbjct: 262 ---KRQEFYVSRMETSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNI 318
Query: 395 TSTHAT--NNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVG-APFYQDGQLQVKVYWKKTE 451
T + + Q V G I + P + PTRP EV P D QL T+
Sbjct: 319 YDVGPTTMHVQWQPVGGATGYILSYKPVKDTEPTRPKEVRLGPTVNDMQL--------TD 370
Query: 452 DPTVNRYHVRWFPEACAHNRT----TGSEASSGMTHENYIILQDLSFS------------ 495
Y V +A H+ T T E + + + L+D++ S
Sbjct: 371 LVPNTEYAVT--VQAVLHDLTSEPVTVREVTLPLPRPQDLKLRDVTHSTMNVFWEPVPGK 428
Query: 496 -----CKYKVTVQPIRPKSHSKAEAVFFTTPPCS-ALKGKSHKPVGCLGEAGHVLSKVLA 549
+YK + ++ ++E S L S V GE+ V ++
Sbjct: 429 VRKYIVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTLYTVSVSAVHDEGESPPVTAQETT 488
Query: 550 KPENLSASFIVQDVNITG-HFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQ 608
+P + + +V G +W ++ ++ +++TWA + + +
Sbjct: 489 RPVPAPTNLKITEVTSEGFRGTWDHGASD----VSLYRITWAPFGSSDKMET-------- 536
Query: 609 SQILPSDHYVLTVPNLRPSTLYRLEVQVLTP---------GGEGPATIKTFRTPELPP 657
IL D L NL P+T+Y + + + P G E I T + P+ P
Sbjct: 537 --ILNGDENTLVFENLNPNTIYEVSITAIYPDESESDDLIGSERTLPILTTQAPKSGP 592
Score = 30.4 bits (67), Expect = 5.6
Identities = 47/197 (23%), Positives = 68/197 (34%), Gaps = 44/197 (22%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P + L+ S L VKW +P VQ+ + PS + T
Sbjct: 588 PKSGPRNLQVYNATSNSLTVKW--------DPASGRVQK-YRITYQPSTGEGNEQTTTIG 638
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGT------RGFTAPSKHFRSSKDPSAPPAPANL 296
V L ++P Y V+++ G RG T P R NL
Sbjct: 639 GRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVR------------NL 686
Query: 297 RLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSS-KSLVPTKKKRRKTTDGF 355
R+ + + + T+ + WD E YK+F++ + LVP G
Sbjct: 687 RVYDPSTS-----TLNVRWDHAEGNP---RQYKLFYAPAAGGPEELVPIP--------GN 730
Query: 356 QNSVILEKLQPDCDYVV 372
N IL LQPD Y V
Sbjct: 731 TNYAILRNLQPDTSYTV 747
>gi|93141047 collagen, type XII, alpha 1 long isoform precursor [Homo
sapiens]
Length = 3063
Score = 41.6 bits (96), Expect = 0.002
Identities = 53/210 (25%), Positives = 83/210 (39%), Gaps = 35/210 (16%)
Query: 169 GHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVI-YVVQRRWNYGI 227
G T +TL +G+ + ++ L+V+W + PV+ Y V G
Sbjct: 1923 GRTSDTGRTLMRGLA----RNVQVYNPTPNSLDVRWDP----APGPVLQYRVVYSPVDGT 1974
Query: 228 HPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDP 287
PSE V V L + P Y + A+ G G +P++ +
Sbjct: 1975 RPSES------IVVPGNTRMVHLERLIPDTLYSVNLVALYSDG-EGNPSPAQGRTLPRS- 2026
Query: 288 SAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKK 347
P NLR+ T NS +++ WD D PV Y++ +S V T
Sbjct: 2027 ----GPRNLRVFGETTNS-----LSVAWD---HADGPVQQYRIIYSPTVGDPIDEYT--- 2071
Query: 348 RRKTTDGFQNSVILEKLQPDCDYVVELQAI 377
T G +N+VIL+ LQPD Y + + A+
Sbjct: 2072 ---TVPGRRNNVILQPLQPDTPYKITVIAV 2098
Score = 38.1 bits (87), Expect = 0.027
Identities = 76/356 (21%), Positives = 125/356 (35%), Gaps = 103/356 (28%)
Query: 293 PANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTT 352
P NL++ N+T NS +T+ WD V Y++ + + ++ T
Sbjct: 1756 PRNLQVYNATSNS-----LTVKWDPASGR---VQKYRITYQPSTGEGN------EQTTTI 1801
Query: 353 DGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKG 412
G QNSV+L+KL+PD Y + + ++ G+ G
Sbjct: 1802 GGRQNSVVLQKLKPDTPYTITVSSLYPDGE-----------------------------G 1832
Query: 413 GIQTQLPFQRRRPTRPLEV--GAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHN 470
G T R T+PL Y + V W E +Y + + P A
Sbjct: 1833 GRMT-----GRGKTKPLNTVRNLRVYDPSTSTLNVRWDHAEG-NPRQYKLFYAPAAGGPE 1886
Query: 471 RTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKS 530
++ NY IL++L Y VTV P+ +
Sbjct: 1887 ELVPIPGNT-----NYAILRNLQPDTSYTVTVVPVYTEGDG------------------- 1922
Query: 531 HKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGH---FSWKMAKANLYQPMTGFQV 587
G + G L + LA+ VQ N T + W A P+ ++V
Sbjct: 1923 ----GRTSDTGRTLMRGLARN--------VQVYNPTPNSLDVRWDPAPG----PVLQYRV 1966
Query: 588 TWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEG 643
++ V + P S+S ++P + ++ + L P TLY + + L GEG
Sbjct: 1967 VYSPV-----DGTRP----SESIVVPGNTRMVHLERLIPDTLYSVNLVALYSDGEG 2013
Score = 36.2 bits (82), Expect = 0.10
Identities = 89/418 (21%), Positives = 153/418 (36%), Gaps = 82/418 (19%)
Query: 283 SSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLV 342
S K P AP+NL ++ T S + W P + V YKV + + VS
Sbjct: 1378 SVKGPGDLEAPSNLVISERTHRS-----FRVSWTPPSDS---VDRYKVEY-YPVSGG--- 1425
Query: 343 PTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAIT--------YWGQTRLKSAKVSLHF 394
K++ + S +L+ L+P+ +YVV + ++ + L VSL+
Sbjct: 1426 ---KRQEFYVSRMETSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNI 1482
Query: 395 TSTHAT--NNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVG-APFYQDGQLQVKVYWKKTE 451
T + + Q V G I + P + PTRP EV P D QL T+
Sbjct: 1483 YDVGPTTMHVQWQPVGGATGYILSYKPVKDTEPTRPKEVRLGPTVNDMQL--------TD 1534
Query: 452 DPTVNRYHVRWFPEACAHNRT----TGSEASSGMTHENYIILQDLSFS------------ 495
Y V +A H+ T T E + + + L+D++ S
Sbjct: 1535 LVPNTEYAVT--VQAVLHDLTSEPVTVREVTLPLPRPQDLKLRDVTHSTMNVFWEPVPGK 1592
Query: 496 -----CKYKVTVQPIRPKSHSKAEAVFFTTPPCS-ALKGKSHKPVGCLGEAGHVLSKVLA 549
+YK + ++ ++E S L S V GE+ V ++
Sbjct: 1593 VRKYIVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTLYTVSVSAVHDEGESPPVTAQETT 1652
Query: 550 KPENLSASFIVQDVNITG-HFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQ 608
+P + + +V G +W ++ ++ +++TWA + + +
Sbjct: 1653 RPVPAPTNLKITEVTSEGFRGTWDHGASD----VSLYRITWAPFGSSDKMET-------- 1700
Query: 609 SQILPSDHYVLTVPNLRPSTLYRLEVQVLTP---------GGEGPATIKTFRTPELPP 657
IL D L NL P+T+Y + + + P G E I T + P+ P
Sbjct: 1701 --ILNGDENTLVFENLNPNTIYEVSITAIYPDESESDDLIGSERTLPILTTQAPKSGP 1756
Score = 32.0 bits (71), Expect = 1.9
Identities = 44/189 (23%), Positives = 72/189 (38%), Gaps = 30/189 (15%)
Query: 186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTD 245
P K+L F+E+ S + WS V Y +D+ T + + T+
Sbjct: 634 PPKDLSFSEVTSYGFKTNWSPAGE-------NVFSYHITYKEAAGDDEVTVVEPASSTS- 685
Query: 246 ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNS 305
V L+ ++P Y V A GF+ P ++++ AP NL++ + T +S
Sbjct: 686 --VVLSSLKPETLYLVNVTA---EYEDGFSIPLAGEETTEEVKG--APRNLKVTDETTDS 738
Query: 306 DGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQ 365
I W + V Y++ + + +S R TT Q LE L
Sbjct: 739 -----FKITW---TQAPGRVLRYRIIYRPVAGGES-------REVTTPPNQRRRTLENLI 783
Query: 366 PDCDYVVEL 374
PD Y V +
Sbjct: 784 PDTKYEVSV 792
Score = 31.2 bits (69), Expect = 3.3
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 9/60 (15%)
Query: 584 GFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEG 643
G++V+W SL + + + + LP D + NL+P T YR+ V GEG
Sbjct: 934 GYRVSW---------KSLYDDVDTGEKNLPEDAIHTMIENLQPETKYRISVFATYSSGEG 984
Score = 30.4 bits (67), Expect = 5.6
Identities = 47/197 (23%), Positives = 68/197 (34%), Gaps = 44/197 (22%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQ 242
P + L+ S L VKW +P VQ+ + PS + T
Sbjct: 1752 PKSGPRNLQVYNATSNSLTVKW--------DPASGRVQK-YRITYQPSTGEGNEQTTTIG 1802
Query: 243 TTDERVQLTDIRPSRWYQFRVAAVNVHGT------RGFTAPSKHFRSSKDPSAPPAPANL 296
V L ++P Y V+++ G RG T P R NL
Sbjct: 1803 GRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVR------------NL 1850
Query: 297 RLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSS-KSLVPTKKKRRKTTDGF 355
R+ + + + T+ + WD E YK+F++ + LVP G
Sbjct: 1851 RVYDPSTS-----TLNVRWDHAEGNP---RQYKLFYAPAAGGPEELVPIP--------GN 1894
Query: 356 QNSVILEKLQPDCDYVV 372
N IL LQPD Y V
Sbjct: 1895 TNYAILRNLQPDTSYTV 1911
Score = 30.0 bits (66), Expect = 7.3
Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 10/64 (15%)
Query: 449 KTEDPTVNRYHVRWFP---EACAHNRT---TGSEASSGM----THENYIILQDLSFSCKY 498
KT DPT++ + V W P E + T TG + G ++N ++L++L Y
Sbjct: 1094 KTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTY 1153
Query: 499 KVTV 502
KV V
Sbjct: 1154 KVNV 1157
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform
1 precursor [Homo sapiens]
Length = 1436
Score = 41.6 bits (96), Expect = 0.002
Identities = 47/206 (22%), Positives = 81/206 (39%), Gaps = 27/206 (13%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGI---HPSEDDATHWQT 239
P++ K L F E+Q+ QL ++W EP+ Y V R Y + + ++H QT
Sbjct: 383 PMRAPKGLAFAEIQARQLTLQW--------EPLGYNVTRCHTYTVSLCYHYTLGSSHNQT 434
Query: 240 VAQTTD-----ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ + R + ++ P R R+ N G + K D P A
Sbjct: 435 IRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRK----EGKEVTFQTDEDVPSGIA 490
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDG 354
A S + + + W+ P+EP+ + Y++ + + SS V RR T
Sbjct: 491 ----AESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRR-TISK 545
Query: 355 FQNSV--ILEKLQPDCDYVVELQAIT 378
+N + L P Y+ ++A T
Sbjct: 546 LRNETYHVFSNLHPGTTYLFSVRART 571
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform
2 precursor [Homo sapiens]
Length = 1442
Score = 41.6 bits (96), Expect = 0.002
Identities = 47/206 (22%), Positives = 81/206 (39%), Gaps = 27/206 (13%)
Query: 183 PLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGI---HPSEDDATHWQT 239
P++ K L F E+Q+ QL ++W EP+ Y V R Y + + ++H QT
Sbjct: 383 PMRAPKGLAFAEIQARQLTLQW--------EPLGYNVTRCHTYTVSLCYHYTLGSSHNQT 434
Query: 240 VAQTTD-----ERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPA 294
+ + R + ++ P R R+ N G + K D P A
Sbjct: 435 IRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRK----EGKEVTFQTDEDVPSGIA 490
Query: 295 NLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDG 354
A S + + + W+ P+EP+ + Y++ + + SS V RR T
Sbjct: 491 ----AESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRR-TISK 545
Query: 355 FQNSV--ILEKLQPDCDYVVELQAIT 378
+N + L P Y+ ++A T
Sbjct: 546 LRNETYHVFSNLHPGTTYLFSVRART 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,855,465
Number of Sequences: 37866
Number of extensions: 1452597
Number of successful extensions: 5338
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 4518
Number of HSP's gapped (non-prelim): 853
length of query: 680
length of database: 18,247,518
effective HSP length: 109
effective length of query: 571
effective length of database: 14,120,124
effective search space: 8062590804
effective search space used: 8062590804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.