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Search of human proteins with 239756241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily
a-like [Homo sapiens]
(899 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 1840 0.0
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 1251 0.0
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 810 0.0
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 721 0.0
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 713 0.0
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 640 0.0
gi|239750781 PREDICTED: golgi autoantigen, golgin subfamily a-li... 531 e-151
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 419 e-117
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 416 e-116
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 403 e-112
gi|148746195 trichohyalin [Homo sapiens] 335 1e-91
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 270 4e-72
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 268 2e-71
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 256 7e-68
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 254 3e-67
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 253 6e-67
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 251 2e-66
gi|221219020 NYD-SP11 protein [Homo sapiens] 239 6e-63
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi... 219 7e-57
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 205 2e-52
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 183 7e-46
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 174 4e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 174 4e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 174 4e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 174 4e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 174 4e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 174 4e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 174 4e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 174 4e-43
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 170 5e-42
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 1840 bits (4766), Expect = 0.0
Identities = 899/899 (100%), Positives = 899/899 (100%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET
Sbjct: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY
Sbjct: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
Query: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE
Sbjct: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE
Sbjct: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE
Sbjct: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
Query: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ
Sbjct: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
Query: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW
Sbjct: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480
EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480
Query: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
Query: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
Query: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
Query: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840
EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG
Sbjct: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840
Query: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSPPI 899
QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSPPI
Sbjct: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSPPI 899
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 1251 bits (3238), Expect = 0.0
Identities = 657/846 (77%), Positives = 693/846 (81%), Gaps = 128/846 (15%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGT ATDTKKKKIN+GTNPET
Sbjct: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPET 60
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TTS GCHSPED EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY
Sbjct: 61 TTSEGCHSPED----------EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 110
Query: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
SQDAARKFEDGNL GESKDLAGRLHHSWHFAGE
Sbjct: 111 SQDAARKFEDGNL----------------------------GESKDLAGRLHHSWHFAGE 142
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
LQRALSAVST HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL LAESE
Sbjct: 143 LQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESE 202
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE
Sbjct: 203 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 262
Query: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
RLREQEGKMREQEEKM RQEKRLREQEKELREQEKELREQK+LREQEEQMQEQEEKMWEQ
Sbjct: 263 RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQ 322
Query: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480
EQ EKM+EE++++E+EKK R++EE M+E QEEKMQKQEENM
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMRE--------------------QEEKMQKQEENM 422
Query: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR
Sbjct: 423 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 482
Query: 541 EQEDQMWEQEEKMRDQEQKMWDQEERM-----------------------------EKKT 571
EQEDQMWEQEEKMRDQEQKMWDQEERM EKKT
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKT 542
Query: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM+EQEEKMWEQEE
Sbjct: 543 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE 602
Query: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
KMQEQEEKMWEQEEKMWEQE E+ ++ EQ+E +WE E EKMQEQEEK+WEQE
Sbjct: 603 KMQEQEEKMWEQEEKMWEQE----EEDKMQEQEEMMWEQE-----EKMQEQEEKMWEQE- 652
Query: 692 MEKKTQEQEKKTWDQEKMRE-EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM 750
EKMRE EE MRE+E+KM+ +EE MREQEEKMQ QEEKM+EQEE+M
Sbjct: 653 ---------------EKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697
Query: 751 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKM 810
QEEKMW QEEKMW Q+ EK+W E+M+ E+EE++RDQ+EKM +E++
Sbjct: 698 RGQEEKMWGQEEKMWGQE------EKMWGQEEMR------EKEERIRDQKEKM---QERL 742
Query: 811 RGQEEK 816
EE+
Sbjct: 743 PEHEER 748
Score = 605 bits (1560), Expect = e-173
Identities = 360/687 (52%), Positives = 469/687 (68%), Gaps = 104/687 (15%)
Query: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELRE-QEKELREQK 341
E EKK Q ++ R+E + Q+ +R + E L + R+ ++ L E K
Sbjct: 70 EDEKKASHQHQEALRRE--IEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESK 127
Query: 342 ELREQ---------EEQMQEQEEKMWEQ------EEKMREQEE---KMWRQEERLWEQEK 383
+L + E Q W + EE +E++ +++R E +K
Sbjct: 128 DLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKK 187
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV-------EKMREEKKMQEQE 436
+ E ++K+R E E ++E + ++ + + QV E R+E++++EQE
Sbjct: 188 KNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 247
Query: 437 KKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
KK R QEEKM ++EER+RE+E KMRE+EE MR QE+++++QE+ + EQE++ +Q++L E
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLRE 307
Query: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEE-MWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Q +E+MQEQEEK+WEQEEK+R+QEE MW QE+++W QEK QM EQE+KMR
Sbjct: 308 Q------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK------QMREQEQKMR 355
Query: 555 DQEQKMWDQEERMEKKTQE--QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
DQE++MW+Q+ER+ +K + +++K W+QEEKM+EEER+REREKKMREEEE MREQEEKM
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKM 415
Query: 613 QEQEEKMQEQEEKMWEQE------------EKMQEQEEKMWEQEEK------MWEQEEKM 654
Q+QEE M EQEEK W+Q+ EKMQEQEEK+WEQEEK MW QE+KM
Sbjct: 416 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 475
Query: 655 WEQQRLPEQKEKLWEHE-KMQEQE-KMQEQEEKIWEQ---------------------EK 691
W Q+++ EQ++++WE E KM++QE KM +QEE++WEQ EK
Sbjct: 476 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEK 535
Query: 692 M--EKKTQEQEKKTWDQE-KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
M EKKTQEQEKKTWDQE KMREEE MREREKKMREEEEMMREQEEKMQEQEEKM+EQEE
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEE 595
Query: 749 EMWEQEEKM-------WEQEEKMWEQQ---RLPEQKEKLWEHE-KMQEQE-KIWEQEEKM 796
+MWEQEEKM WEQEEKMWEQ+ ++ EQ+E +WE E KMQEQE K+WEQEEKM
Sbjct: 596 KMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655
Query: 797 RDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM---E 853
R+QEEKMR QEEKM+GQEEKMR QEEKM GQEEKM QEEKM GQEEKMWGQEEKM E
Sbjct: 656 REQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQE 715
Query: 854 EKMQGQEEKMREQEEKMRGQEEKMREQ 880
EKM GQEE MRE+EE++R Q+EKM+E+
Sbjct: 716 EKMWGQEE-MREKEERIRDQKEKMQER 741
Score = 406 bits (1044), Expect = e-113
Identities = 238/481 (49%), Positives = 325/481 (67%), Gaps = 81/481 (16%)
Query: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515
+K R EE +E++ + N EE + + L QEK++ E + E
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL---------QEKLRLAESEKSE 205
Query: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE 575
+ +++ + + K + Q + +++MW QEE++R+QE KK ++QE
Sbjct: 206 IQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-----------KKIRKQE 254
Query: 576 KKTWDQEEKMREEE-RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ 634
+K W QEE++RE+E +MRE+E+KMR +E+ +REQE++++EQE++++EQ+ K+ EQEE+MQ
Sbjct: 255 EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQK-KLREQEEQMQ 313
Query: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-MQEQE-KMQEQEEKIWEQEKM 692
EQEEKMWEQEEKM EQEEKMW Q+ E+LWE EK M+EQE KM++QEE++WEQ++
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQE------ERLWEQEKQMREQEQKMRDQEERMWEQDE- 366
Query: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
+ +E+E E+MRE+E M E+E+KM+EEE + RE+E+KM+E+EE M+EQEE+M +
Sbjct: 367 --RLREKE------ERMREQEKMWEQEEKMQEEERI-REREKKMREEEETMREQEEKMQK 417
Query: 753 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ-EKIWEQEEKMRDQE----------- 800
QEE MWEQEEK W+QQRLPEQKEKLWE EKMQEQ EKIWEQEEK+RDQE
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 477
Query: 801 -EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEE-------------KMWGQEEKM- 845
EKMR QE++M QEEKMR QE+KMW QEE+MW Q+E KMW QEEKM
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMR 537
Query: 846 ------------WGQEEKM--EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
W QEEKM EE+M+ +E+KMRE+EE MR QEEKM+EQEEKMR QEEK+
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Query: 892 Y 892
+
Sbjct: 598 W 598
Score = 234 bits (597), Expect = 3e-61
Identities = 145/331 (43%), Positives = 226/331 (68%), Gaps = 38/331 (11%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEEL--KKKNAELQEKLPLAESEKSEIQLNVKE 250
+K + +E +E++ E EE+ ++K QEK+ E + E + +++
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 251 LKRKL--------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW------ 296
++K+ E+ + L + + Q++MW+QEE++RE EKK ++QE+K W
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE-EKKTQEQEKKTWDQEEKM 556
Query: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE-LREQEEQMQEQEE 355
R+EER+RE+E KMRE+EE M QE++++EQE+++REQE+++ EQ+E ++EQEE+M EQEE
Sbjct: 557 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 616
Query: 356 KMWEQEE--KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
KMWEQEE KM+EQEE MW QEE++ EQE++M EQE+KMR+QEE+M EQ+E+++ +EE+M
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676
Query: 414 REQEKMWEQVEKMR-EEKKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEE 471
REQE EKM+ +E+KM+EQE+K R QEEKM +EE++ +E+KM +EE MRE+EE
Sbjct: 677 REQE------EKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE-MREKEE 729
Query: 472 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
+++ Q+E M Q+RLPE +E+ E
Sbjct: 730 RIRDQKEKM---------QERLPEHEERCSE 751
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 810 bits (2093), Expect = 0.0
Identities = 457/810 (56%), Positives = 590/810 (72%), Gaps = 114/810 (14%)
Query: 5 PHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSG 64
PHLP HPMMS++TRQ+KLAEAK++ TD+ VGT A+DTKKKKIN+GTNPETTTSG
Sbjct: 43 PHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSG 102
Query: 65 GCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA 124
GCHSPED E+KASHQHQEALRRE+EAQ HTIRILTCQKTEL+ ALYYSQ A
Sbjct: 103 GCHSPED----------EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHA 152
Query: 125 ARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA 184
++ E GE++DL RLH SW FAGEL++A
Sbjct: 153 VKQLE--------------------------------GEARDLISRLHDSWKFAGELEQA 180
Query: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEI 244
LSAV+T+ KKADRYIEELTKERDALSLELYRNTIT+EELK+KNA+LQEKL L ESEKSEI
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ--EEKMWRQEERL 302
QLNVKELKRKLERAK LLPQ Q LQ E +EL+ K++ Q E ++W RL
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKLQAQVEENELWN---RL 294
Query: 303 REQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE 362
+Q QEEKMWRQE++++E E++++ EQEE+++EQEEK+ EQEE
Sbjct: 295 NQQ------QEEKMWRQEEKIQEWEEKIQ-------------EQEEKIREQEEKIREQEE 335
Query: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
KMR QEE MW +EE++ QE+ M E+E+KMR QEE MWE++E++R R++E MWE+
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR------RQEEMMWEK 389
Query: 423 VEKMRE-EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481
EK+RE E+KM EQEK R+QEEK QEEE+IRE+EK+ +E+E M QEEK+++QEE +
Sbjct: 390 EEKIRELEEKMHEQEK-IREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR 447
Query: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE-KMR 540
EQE+K W+Q+ ++EK+ E+EK QEQEE +W QEEKI +QEE+W Q++KM QE K+R
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKRQEQEE-MWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 541 EQEDQMWEQEEKMRDQEQKMWDQEERM---EKKTQEQEKKTWDQEEKMREEERMREREKK 597
+QE+++W QEEK+R+QE+K+ +QEE+M E+K +EQE+ W +EEKM E+E++ E EK+
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM-WREEEKMHEQEKIWEEEKR 565
Query: 598 MREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
+E++M R QEEK++EQEEK+ QEEK+ EQEEK QEQEEKMW+QEEK+ EQEEK+ EQ
Sbjct: 566 QEQEDKMWR-QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
Query: 658 Q-RLPEQKEKLWEHEKM--QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
+ ++ EQ+EK+ E E+M +++EKM EQEEK+ EQE+ K QEQE+ W R+EE
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE---KMQEQEETMW-----RQEEK 676
Query: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774
+RE+EKK+RE+EE +REQEE MQEQEEKM EQEE+M EQEEKM EQEEKM
Sbjct: 677 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM---------- 726
Query: 775 EKLWEHEKMQEQEKIWEQEEKMRDQEEKMR 804
+++EK+WEQE ++R QEEKM+
Sbjct: 727 --------RRQEEKMWEQEVRLRQQEEKMQ 748
Score = 790 bits (2039), Expect = 0.0
Identities = 443/831 (53%), Positives = 576/831 (69%), Gaps = 170/831 (20%)
Query: 1 MWPQPH------------------------------------LPPHPMMSEKTRQNKLAE 24
MWPQPH LP HPMMS++TRQ+KLAE
Sbjct: 3 MWPQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAE 62
Query: 25 AKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKK 84
AK++ TD+ VGT A+DTKKKKIN+GTNPETTTSGGCHSPED E+K
Sbjct: 63 AKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED----------EQK 112
Query: 85 ASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS 144
ASHQHQEALRRE+EAQ HTIRILTCQKTEL+ ALYYSQ A ++ E
Sbjct: 113 ASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE--------------- 157
Query: 145 QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTK 204
GE++DL RLH SW FAGEL++ALSAV+T+ KKADRYIEELTK
Sbjct: 158 -----------------GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 200
Query: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP- 263
ERDALSLELYRNTIT+EELK+KNA+LQEKL L ESEKSEIQLNVKELKRKLERAK LLP
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ 260
Query: 264 -----------------------QVQTNTL--------QEEMWRQEEELREQEKKIRKQE 292
QV+ N L +E+MWRQEE+++E E+KI++QE
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR-EQEEQMQ 351
EK+ QEE++REQE KMR QEE MW +E+++R QE+ + E+E+++R Q+E+ E+EE+M+
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 352 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE-----QKMRDQEERMWEQDERL 406
QEE MWE+EEK+RE EEKM ++E++ EQE++ +E+E +K ++QE +MW Q+E++
Sbjct: 381 RQEEMMWEKEEKIRELEEKM-HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 407 REKEERMREQE-KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
RE+EE++REQE KMW Q EK+ E++K++E+EK+ ++QEE ++EE+I E+E+ R++E+
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIHEQEEIWRQKEK- 497
Query: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
M EQEEK++KQEE +W QEEK +Q +EK++EQEEK+W QEEKIR+QEE
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEKIREQ------------EEKIREQEEKMWRQEEKIREQEE 545
Query: 526 MWGQEKKM------WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM---EKKTQEQEK 576
MW +E+KM W +EK +EQED+MW QEEK+R+QE+K+W QEE++ E+K QEQE+
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEE 605
Query: 577 KTWDQEEKMRE-EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
K W QEEK+RE EE+++E+E+K+RE+EE +REQEE QEQEEKM EQEEKM EQEEKMQE
Sbjct: 606 KMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
QEE MW QEEK+ EQE+K + EQ+EK+ E E+M MQEQEEK+WEQE
Sbjct: 666 QEETMWRQEEKIREQEKK------IREQEEKIREQEEM-----MQEQEEKMWEQE----- 709
Query: 696 TQEQEKKTWDQEKM-REEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
EKM +EE M+E+E+KMR +EE M EQE ++++QEEKMQE
Sbjct: 710 -----------EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 497 bits (1279), Expect = e-140
Identities = 300/688 (43%), Positives = 450/688 (65%), Gaps = 75/688 (10%)
Query: 204 KERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
+ ++AL EL T L + ELQ L ++ +++ ++L +L
Sbjct: 116 QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH------- 168
Query: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL 323
+ W+ EL + + Q++K R E L ++ + + + ++ L
Sbjct: 169 ---------DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEEL 219
Query: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
+E+ +L+E+ + + +K E Q+ +E K + K+ ++++ + + L ++ +
Sbjct: 220 KEKNAKLQEKLQLVESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE-EKKMQEQEKKTRDQ 442
+ + Q ++ E +W RL +++E EKMW Q EK++E E+K+QEQE+K R+Q
Sbjct: 276 SVSAKLQAQVEENE-LWN---RLNQQQE-----EKMWRQEEKIQEWEEKIQEQEEKIREQ 326
Query: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
EEK IRE+E+KMR +EE M E+EEKM++QEE MWE+EEK + Q+E +WE
Sbjct: 327 EEK------IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK------MRRQEEMMWE 374
Query: 503 -QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
+EKM+ QEE +WE+EEKIR+ EE +++K+ QE+ R++E+++ EQE K ++QE KMW
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE-KRQEQEAKMW 433
Query: 562 DQEERM---EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE--------- 609
QEE++ E+K +EQEKK W QEEK+ E+E++RE EK+ +E+EEM R++E
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIHEQEEIW 492
Query: 610 ---EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
EKM EQEEK+++QEEK+W QEEK++EQEEK+ EQEEKMW QEEK+ EQ+ + ++EK
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
+ E EK+ E+EK QEQE+K+W QE+ K +EQE+K W R+EE +RE+E+K +E+E
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEE---KIREQEEKVW-----RQEEKIREQEEKRQEQE 604
Query: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLWEHE-KMQ 784
E M +QEEK++EQEEK+QEQEE++ EQEEK+ EQEE EQ+ ++ EQ+EK+ E E KMQ
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 664
Query: 785 EQEK-IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 843
EQE+ +W QEEK+R+QE+K+R QEEK+R QEE M+ QEEKMW QEEKM QEEKM QEE
Sbjct: 665 EQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724
Query: 844 KMWGQEEKMEEKMQGQEEKMREQEEKMR 871
KM QEEKM E QE ++R+QEEKM+
Sbjct: 725 KMRRQEEKMWE----QEVRLRQQEEKMQ 748
Score = 452 bits (1162), Expect = e-127
Identities = 290/660 (43%), Positives = 434/660 (65%), Gaps = 71/660 (10%)
Query: 283 EQEKKIRKQEEKMWRQE-----ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
E E+K Q ++ R+E +R + E + ++ + +++ E E R+ L
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 338 REQKELREQEEQ----MQEQEEKMWEQEEKMREQEE----KMWRQ---EERLWEQEKQMR 386
+ + + EQ + Q++K E++ ++ + +++R +E L E+ +++
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 387 EQEQKMRDQEERMWEQDERLREKEERMR---EQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
E+ Q + ++ + + L+ K ER + Q+++ Q E K++Q K + Q
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--QAEADHLGKELQSVSAKLQAQV 285
Query: 444 EKMQEEERI-REREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLW 501
E+ + R+ +++E+KM +EE ++E EEK+Q+QEE + EQEEK Q++++ Q+E +W
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 502 E-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW-RQEKMREQEDQMWEQEEKMRDQEQK 559
E +EKM+ QEE +WE+EEK+R QEEM MW ++EKMR QE+ MWE+EEK+R+ E+K
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEM------MWEKEEKMRRQEEMMWEKEEKIRELEEK 399
Query: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
M +QE K +EQE+K +EEK+RE+E+ +E+E KM +EE +REQEEK++EQE+KM
Sbjct: 400 MHEQE-----KIREQEEKR-QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 453
Query: 620 QEQEEKMWEQE-----EKMQEQEEKMWEQEEKM------WEQEEKMWEQQ-RLPEQKEKL 667
QEEK+ EQE EK QEQEE MW QEEK+ W Q+EKM EQ+ ++ +Q+EK+
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEE-MWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512
Query: 668 W-EHEKMQEQE-KMQEQEEKIWEQE----------KMEKKTQEQEKKTWDQEKMRE-EES 714
W + EK++EQE K++EQEEK+W QE + E+K EQE K W++EK +E E+
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE-KIWEEEKRQEQEDK 571
Query: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQ 773
M +E+K+RE+EE + QEEK++EQEEK QEQEE+MW+QEEK+ EQEEK+ EQ +++ EQ
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 774 KEKLWEHEKM--QEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
+EK+ E E+M +++EK+ EQEEKM +QEEKM+ QEE M QEEK+R QE+K+ QEEK+
Sbjct: 632 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
QEE M QEEKMW QEEKM E QEEKM+EQEEKMR QEEKM EQE ++R QEEK+
Sbjct: 692 REQEEMMQEQEEKMWEQEEKMCE----QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 747
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 721 bits (1860), Expect = 0.0
Identities = 401/706 (56%), Positives = 515/706 (72%), Gaps = 93/706 (13%)
Query: 1 MWPQPHLPPHP------------MMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTK 48
MWPQPHLP HP MMS++TRQ+KLAEAK++ TD+ VGT A+DTK
Sbjct: 88 MWPQPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTK 147
Query: 49 KKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILT 108
KKKIN+GTNPETTTSGGCHSPED E+KASHQHQEALRRE+EAQ HTIRILT
Sbjct: 148 KKKINNGTNPETTTSGGCHSPED----------EQKASHQHQEALRRELEAQVHTIRILT 197
Query: 109 CQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLA 168
CQKTEL+ ALYYSQ A ++ E GE++DL
Sbjct: 198 CQKTELQMALYYSQHAVKQLE--------------------------------GEARDLI 225
Query: 169 GRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA 228
RLH SW FAGEL++ALSAV+T+ KKADRYIEELTKERDALSLELYRNTIT+EELK+KNA
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 285
Query: 229 ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI 288
+LQEKL L ESEKSEIQLNVKELKRKLERAK LLPQ Q LQ E +EL+ K+
Sbjct: 286 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKL 342
Query: 289 RKQ--EEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQ 346
+ Q E ++W RL +Q QEEKMWRQE++++E E++++EQE+++REQ
Sbjct: 343 QAQVEENELWN---RLNQQ------QEEKMWRQEEKIQEWEEKIQEQEEKIREQ------ 387
Query: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
EEK+ EQEEKMR QEE MW +EE++ QE+ M E+E+KMR QEE MWE++E++
Sbjct: 388 -------EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 440
Query: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETM 466
RE EE+M EQEK+ EQ EK +EE+K++EQEK+ + + ++EE+IRE+E+K+RE+EE M
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM 500
Query: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE- 525
QEEK+ +QE+ +EEK +Q+ + Q+EK+ EQE++ Q+EKI EQEEKIR QEE
Sbjct: 501 WRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 526 MWGQEKKMW-RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
MW QE+KM ++EK+REQE+++W QEEK+R+QE+K+ +QEE K +EQE+ T +QEEK
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE----KIREQEEMTQEQEEK 614
Query: 585 MRE-EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
M E EE+M E+E+KM+E+EE MR QEEK++EQE+K++EQEEK+ EQEE MQEQEEKMWEQ
Sbjct: 615 MGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 644 EEKMWEQEEKMWEQ-QRLPEQKEKLWEHE--KMQEQEKMQEQEEKI 686
EEKM EQEEKM EQ +++ Q+EK+WE E Q++EKMQE +E +
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 408 bits (1049), Expect = e-113
Identities = 255/596 (42%), Positives = 390/596 (65%), Gaps = 65/596 (10%)
Query: 204 KERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
+ ++AL EL T L + ELQ L ++ +++ ++L +L +
Sbjct: 177 QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAG 236
Query: 264 QVQ-----TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWR 318
+++ T +++ R EEL ++ + + + +E L+E+ K++E+ + +
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 296
Query: 319 QEKRLREQEKELR---EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
++ ++ KEL+ E+ K L Q++L+ + + + ++ + + K++ Q E E
Sbjct: 297 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV---SAKLQAQVE-----E 348
Query: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
LW + Q QEE+MW Q+E+++E EE+++EQE+ K++EQ
Sbjct: 349 NELWNRLNQQ---------QEEKMWRQEEKIQEWEEKIQEQEE------------KIREQ 387
Query: 436 EKKTRDQEEKMQ-EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 494
E+K R+QEEKM+ +EE + E+E+KMR +EE M E+EEKM++QEE MWE+EEK +
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK------IR 441
Query: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
E +EK+ EQEK++EQEEK ++EEKIR+QE+ QE KMWRQE +++ EQEEK+R
Sbjct: 442 ELEEKMHEQEKIREQEEKR-QEEEKIREQEKRQEQEAKMWRQE------EKIREQEEKIR 494
Query: 555 DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 614
+QE+KMW QEE K EQEK +EEK +E+E M +E+K+RE+EE+ R Q+EK+ E
Sbjct: 495 EQEEKMWRQEE----KIHEQEKIR--EEEKRQEQEEMWRQEEKIREQEEIWR-QKEKIHE 547
Query: 615 QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWEHEKM 673
QEEK+++QEEKMW QEEKM +QEEK+ EQEEK+W QEEK+ EQ +++ EQ+EK+ E E+M
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEM 607
Query: 674 --QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE-SMREREKKMREEEEMMR 730
+++EKM EQEEK+ EQE EK +++EK +EK+RE+E +RE+E+K+RE+EEMM+
Sbjct: 608 TQEQEEKMGEQEEKMCEQE--EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 665
Query: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLWEHEKMQE 785
EQEEKM EQEEKM EQEE+M EQEEKM QEEKMWEQ+ RL +Q+EK+ EH++ E
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 402 bits (1032), Expect = e-111
Identities = 264/604 (43%), Positives = 370/604 (61%), Gaps = 77/604 (12%)
Query: 283 EQEKKIRKQEEKMWRQE-----ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
E E+K Q ++ R+E +R + E + ++ + +++ E E R+ L
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228
Query: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
+ + + EQ + Q++K R E L ++ + + + +E
Sbjct: 229 HDSWKFAGELEQALSA----------VATQKKKADRYIEELTKERDALSLELYRNTITDE 278
Query: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
+ E++ +L+EK + + E EK Q+ ++E K+ E+ K Q++ E + + + +
Sbjct: 279 ELKEKNAKLQEKLQLV-ESEKSEIQLN-VKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 458 KMREEEETMREQEEKM----QKQEENMWEQEEK--EWQQQRLPEQKEKLWEQEKMQEQEE 511
+ + + E+ E Q+QEE MW QEEK EW+ EK+QEQEE
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE--------------EKIQEQEE 382
Query: 512 KIWEQEEKIRDQEE-MWGQEKKMW-RQEKMREQEDQMWEQEEKMRDQEQKMWDQEER--- 566
KI EQEEKIR+QEE M QE+ MW ++EKMR QE+ MWE+EEKMR QE+ MW++EE+
Sbjct: 383 KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 442
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
+E+K EQEK +QEEK +EEE++RE+EK+ +E +M R QEEK++EQEEK++EQEEKM
Sbjct: 443 LEEKMHEQEKIR-EQEEKRQEEEKIREQEKRQEQEAKMWR-QEEKIREQEEKIREQEEKM 500
Query: 627 WEQEEKMQEQE-----EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
W QEEK+ EQE EK EQEE MW QEEK+ EQ+ + QKEK+ E E EK+++
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEE-MWRQEEKIREQEEIWRQKEKIHEQE-----EKIRK 554
Query: 682 QEEKIWEQEK----MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
QEEK+W QE+ E+K +EQE+K W R+EE +RE+E+K+RE+EE +REQEE Q
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVW-----RQEEKIREQEEKIREQEEKIREQEEMTQ 609
Query: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-KIWEQEEKM 796
EQEEKM EQEE+M EQEEKM EQEEKM Q+ EK++EQE KI EQEEK+
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE------------EKIREQEKKIREQEEKI 657
Query: 797 RDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKM 856
R+QEE M+ QEEKM QEEKM QEEKM QEEKM QEEKMW QE ++ QEEKM+E
Sbjct: 658 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
Query: 857 QGQE 860
+ E
Sbjct: 718 EHLE 721
Score = 395 bits (1016), Expect = e-110
Identities = 250/574 (43%), Positives = 370/574 (64%), Gaps = 38/574 (6%)
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
EQ+ QE RE E ++ ++ EL+ Q +++ + + +
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230
Query: 371 MWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
W+ L + + Q++K R EE E+D E E++ E+ K++E+
Sbjct: 231 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 290
Query: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---EKMQKQEENMWEQ-EE 485
++ E EK + + ++E +R ER K + +++ E + +++Q + Q EE
Sbjct: 291 LQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 348
Query: 486 KEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
E + +Q+EK+W QE K+QE EEKI EQEEKIR+QEE K ++EKMR QE+
Sbjct: 349 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEE 403
Query: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEE 603
MWE+EEKMR QE+ MW++EE K + QE+ W++EEK+RE EE+M E+EK +RE+EE
Sbjct: 404 MMWEKEEKMRRQEEMMWEKEE----KMRRQEEMMWEKEEKIRELEEKMHEQEK-IREQEE 458
Query: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
R++EEK++EQE K QEQE KMW QEEK++EQEEK+ EQEEKMW QEEK+ EQ+++ E+
Sbjct: 459 K-RQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Query: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEK----MEKKTQEQEKKTWDQEKMR--EEESMRE 717
+++ + E +++EK++EQEE IW Q++ E+K ++QE+K W QE+ +EE +RE
Sbjct: 517 EKRQEQEEMWRQEEKIREQEE-IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Query: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEK 776
+E+K+ +EE +REQEEK++EQEEK++EQEE EQEEKM EQEEKM EQ+ ++ EQ+EK
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEK 635
Query: 777 LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEE 836
+ +++EKI EQE+K+R+QEEK+R QEE M+ QEEKM QEEKM QEEKM QEE
Sbjct: 636 M-----RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 837 KMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKM 870
KM QEEKMW QE ++ + QEEKM+E +E +
Sbjct: 691 KMRRQEEKMWEQEVRLRQ----QEEKMQEHQEHL 720
Score = 383 bits (983), Expect = e-106
Identities = 236/536 (44%), Positives = 344/536 (64%), Gaps = 34/536 (6%)
Query: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
E EQK Q + ++ + R+ +K Q+ + +++ E + RD ++
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228
Query: 447 QEEERIR-EREKKMR----EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
+ + E E+ + ++++ R EE ++++ E + L E+ KL
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL- 287
Query: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
QEK+Q E + E + +++ + + K + Q++++ + D + ++ + + + Q
Sbjct: 288 -QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 346
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMRE--------EERMREREKKMREEEEMMREQEEKMQ 613
++ E + Q+QE+K W QEEK++E EE++RE+E+K+RE+EE MR QEE M
Sbjct: 347 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 406
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E+EEKM+ QEE MWE+EEKM+ QEE MWE+EEK+ E EEKM EQ+++ EQ+EK E EK+
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 466
Query: 674 QEQEKMQEQEEKIWEQEK----MEKKTQEQEKKTWDQE-KMREEESMREREKKMREEEEM 728
+EQEK QEQE K+W QE+ E+K +EQE+K W QE K+ E+E +RE EK R+E+E
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK--RQEQEE 524
Query: 729 MREQEEKMQEQEE------KMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLW-EH 780
M QEEK++EQEE K+ EQEE++ +QEEKMW QEEKM +Q+ ++ EQ+EK+W +
Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584
Query: 781 EKMQEQE-KIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMW 839
EK++EQE KI EQEEK+R+QEE + QEEKM QEEKM QEEKM QEEKM QEEK+
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644
Query: 840 GQEEKMWGQEEKM---EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
QE+K+ QEEK+ EE MQ QEEKM EQEEKM QEEKM+EQEEKMR QEEK++
Sbjct: 645 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 700
Score = 291 bits (745), Expect = 2e-78
Identities = 183/470 (38%), Positives = 288/470 (61%), Gaps = 36/470 (7%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E+ + R L E + E L+ + ++++ +K+E++ + ++ RK E
Sbjct: 257 EELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV---KELKRKLE 313
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSL-IPGESKDLAGRLHHS-----WHFAGELQR 183
L P L G L VS L E +L RL+ W ++Q
Sbjct: 314 RAKLLLPQQ-QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 372
Query: 184 ALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---ELQEKLPLAESE 240
+ + +K E++ ++ + + + E+++++ E +EK+ E
Sbjct: 373 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE-------------MWRQEEELREQEKK 287
E + ++EL+ K+ + + Q + +E+ MWRQEE++REQE+K
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 288 IRKQEEKMWRQEERLREQEGKMREQE-----EKMWRQEKRLREQEKELREQEKELREQKE 342
IR+QEEKMWRQEE++ EQE K+RE+E E+MWRQE+++REQE+ R++EK ++++
Sbjct: 493 IREQEEKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402
+R+QEE+M QEEKM +QEEK+REQEEK+WRQEE++ EQE+++REQE+K+R+QEE EQ
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQ 611
Query: 403 DERLREKEERMREQE-KMWEQVEKMR-EEKKMQEQEKKTRDQEEKMQE-EERIREREKKM 459
+E++ E+EE+M EQE KM EQ EKMR +E+K++EQEKK R+QEEK++E EE ++E+E+KM
Sbjct: 612 EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 671
Query: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLWEQEKMQE 508
E+EE M EQEEKMQ+QEE M QEEK W+Q+ RL +Q+EK+ E ++ E
Sbjct: 672 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 713 bits (1840), Expect = 0.0
Identities = 395/699 (56%), Positives = 506/699 (72%), Gaps = 94/699 (13%)
Query: 5 PHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSG 64
PHLP HPMMS++TRQ+KLAEAK++ TD+ VGT A+DTKKKKIN+GTNPETTTSG
Sbjct: 43 PHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSG 102
Query: 65 GCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA 124
GCHSPED E+KASHQHQEALRRE+EAQ HTIRILTCQKTEL+ ALYYSQ A
Sbjct: 103 GCHSPED----------EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHA 152
Query: 125 ARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA 184
++ E GE++DL RLH SW FAGEL++A
Sbjct: 153 VKQLE--------------------------------GEARDLISRLHDSWKFAGELEQA 180
Query: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEI 244
LSAV+T+ KKADRYIEELTKERDALSLELYRNTIT+EELK+KNA+LQEKL L ESEKSEI
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ--EEKMWRQEERL 302
QLNVKELKRKLERAK LLPQ Q LQ E +EL+ K++ Q E ++W RL
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKLQAQVEENELWN---RL 294
Query: 303 REQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE 362
+Q QEEKMWRQE++++E E++++EQE+++REQ EEK+ EQEE
Sbjct: 295 NQQ------QEEKMWRQEEKIQEWEEKIQEQEEKIREQ-------------EEKIREQEE 335
Query: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
KMR QEE MW +EE++ QE+ M E+E+KMR EE MWE++E++RE EE+M EQEK+ EQ
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395
Query: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE----- 477
EK +EE+K++EQEK+ + + ++EE+IRE+E+K+RE+E+ M QEEK+ +QE
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 455
Query: 478 ------ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE-MWGQE 530
E MW QEEK +Q+ + QKEK+ EQEK+++QEEK+W QEEK+ DQEE + QE
Sbjct: 456 EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE 515
Query: 531 KKMWRQE-KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEE 589
+KMWRQE K+REQE+++ EQEEK+R+QE+ M +QEE+M EQE+K +QE+ R+EE
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG----EQEEKMQEQEKMRRQEE 571
Query: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
++RE+E+K+RE++E +REQEEK+ EQEEK++EQEE M EQEEKM EQEEKM EQEEKM E
Sbjct: 572 KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 631
Query: 650 QEEKMWEQQRLPEQKEKLWEHE--KMQEQEKMQEQEEKI 686
QEEKM Q+EK+WE E Q++EKMQE +E +
Sbjct: 632 QEEKM------RRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 635 bits (1639), Expect = 0.0
Identities = 366/724 (50%), Positives = 474/724 (65%), Gaps = 185/724 (25%)
Query: 1 MWPQPH------------------------------------LPPHPMMSEKTRQNKLAE 24
MWPQPH LP HPMMS++TRQ+KLAE
Sbjct: 3 MWPQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAE 62
Query: 25 AKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKK 84
AK++ TD+ VGT A+DTKKKKIN+GTNPETTTSGGCHSPED E+K
Sbjct: 63 AKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED----------EQK 112
Query: 85 ASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS 144
ASHQHQEALRRE+EAQ HTIRILTCQKTEL+ ALYYSQ A ++ E
Sbjct: 113 ASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE--------------- 157
Query: 145 QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTK 204
GE++DL RLH SW FAGEL++ALSAV+T+ KKADRYIEELTK
Sbjct: 158 -----------------GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 200
Query: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP- 263
ERDALSLELYRNTIT+EELK+KNA+LQEKL L ESEKSEIQLNVKELKRKLERAK LLP
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ 260
Query: 264 -----------------------QVQTNTL--------QEEMWRQEEELREQEKKIRKQE 292
QV+ N L +E+MWRQEE+++E E+KI++QE
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLR---------------------EQEKELR 331
EK+ QEE++REQE KMR QEE MW +E+++R E+E+++R
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR 380
Query: 332 EQEKELREQKELREQE------------EQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
E E+++ EQ+++REQE E+ QEQE KMW QEEK+REQEEK+ QE+++W
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 380 EQEKQMREQ----EQKMRDQEERMWEQDERLREKE------ERMREQEKMWEQVEKM-RE 428
QE+++ EQ E++ R ++E MW Q+E++RE+E E+M EQEK+ +Q EK+ R+
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 429 EKKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
E+KM +QE+K R+QEEKM ++EE+IRE+E+K+RE+EE +REQEE MQ+QEE M EQEEK
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 488 WQQQRLPEQKEKLWEQ--------EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
+Q+++ Q+EK+ EQ EK++EQEEKIWEQEEKIR+QEEM M
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM------------M 608
Query: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
+EQE++MWEQEEKM +QE+KM +QEE+M + QE+K W+Q E R+R++E+KM+
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRR----QEEKMWEQ------EVRLRQQEEKMQ 658
Query: 600 EEEE 603
E +E
Sbjct: 659 EHQE 662
Score = 409 bits (1052), Expect = e-114
Identities = 258/586 (44%), Positives = 378/586 (64%), Gaps = 43/586 (7%)
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
EQ+ QE RE E ++ ++ EL+ Q +++ + + +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 371 MWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
W+ L + + Q++K R EE E+D E E++ E+ K++E+
Sbjct: 170 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 229
Query: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---EKMQKQEENMWEQ-EE 485
++ E EK + + ++E +R ER K + +++ E + +++Q + Q EE
Sbjct: 230 LQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 486 KEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
E + +Q+EK+W QE K+QE EEKI EQEEKIR+QEE K ++EKMR QE+
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEE 342
Query: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEE 603
MWE+EEKMR QE+ MW++EE+M + E+ W++EEK+RE EE+M E+EK +RE+EE
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRL----EEMMWEKEEKIRELEEKMHEQEK-IREQEE 397
Query: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
R++EEK++EQE K QEQE KMW QEEK++EQEEK+ EQE+KMW QEEK+ EQ+++ E+
Sbjct: 398 K-RQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 455
Query: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQ-EKM--EKKTQEQEKKTWDQEKMR--EEESMRER 718
+++ + E +++EK++EQEE IW Q EKM ++K ++QE+K W QE+ +EE +RE+
Sbjct: 456 EKRQEQEEMWRQEEKIREQEE-IWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
E+KM +EE +REQEEK++EQEEK++EQEE M EQEEKM EQEEKM EQ+++ Q+EK+
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR 574
Query: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
E E EKI EQ+EK+R+QEEK+ QEEK+R QEE M+ QEEKMW QEEKM QEEKM
Sbjct: 575 EQE-----EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Query: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
++ EEKM+ QEEKM EQE ++R QEEKM+E +E +
Sbjct: 630 -----------QEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 397 bits (1019), Expect = e-110
Identities = 257/596 (43%), Positives = 389/596 (65%), Gaps = 60/596 (10%)
Query: 204 KERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
+ ++AL EL T L + ELQ L ++ +++ ++L +L
Sbjct: 116 QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH------- 168
Query: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL 323
+ W+ EL + + Q++K R E L ++ + + + ++ L
Sbjct: 169 ---------DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEEL 219
Query: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
+E+ +L+E+ + + +K E Q+ +E K + K+ ++++ + + L ++ +
Sbjct: 220 KEKNAKLQEKLQLVESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE-EKKMQEQEKKTRDQ 442
+ + Q ++ E +W RL +++E EKMW Q EK++E E+K+QEQE+K R+Q
Sbjct: 276 SVSAKLQAQVEENE-LWN---RLNQQQE-----EKMWRQEEKIQEWEEKIQEQEEKIREQ 326
Query: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
EEK IRE+E+KMR +EE M E+EEKM++QEE MWE+EEK +RL +E +WE
Sbjct: 327 EEK------IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK---MRRL---EEMMWE 374
Query: 503 -QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
+EK++E EEK+ EQE KIR+QEE +E+K+ QEK +EQE +MW QEEK+R+QE+K+
Sbjct: 375 KEEKIRELEEKMHEQE-KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 562 DQEERM---EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 618
+QE++M E+K EQEK +EEK +E+E M +E+K+RE+EE+ R Q+EKM EQ EK
Sbjct: 434 EQEKKMWRQEEKIHEQEKIR--EEEKRQEQEEMWRQEEKIREQEEIWR-QKEKMHEQ-EK 489
Query: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWEHEKM--QE 675
+++QEEK+W QEEKM +QEEK+ EQEEKMW QEEK+ EQ +++ EQ+EK+ E E+M ++
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 676 QEKMQEQEEKIWEQEKM---EKKTQEQEKKTWDQ-EKMRE-EESMREREKKMREEEEMMR 730
+EKM EQEEK+ EQEKM E+K +EQE+K +Q EK+RE EE + E+E+K+RE+EEMM+
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609
Query: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLWEHEKMQE 785
EQEEKM EQEEKM EQEE+M EQEEKM QEEKMWEQ+ RL +Q+EK+ EH++ E
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 376 bits (966), Expect = e-104
Identities = 236/542 (43%), Positives = 345/542 (63%), Gaps = 41/542 (7%)
Query: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
E EQK Q + ++ + R+ +K Q+ + +++ E + RD ++
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 447 QEEERIR-EREKKMR----EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
+ + E E+ + ++++ R EE ++++ E + L E+ KL
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL- 226
Query: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
QEK+Q E + E + +++ + + K + Q++++ + D + ++ + + + Q
Sbjct: 227 -QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMRE--------EERMREREKKMREEEEMMREQEEKMQ 613
++ E + Q+QE+K W QEEK++E EE++RE+E+K+RE+EE MR QEE M
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E+EEKM+ QEE MWE+EEKM+ EE MWE+EEK+ E EEKM EQ+++ EQ+EK E EK+
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405
Query: 674 QEQEKMQEQEEKIWEQEK----MEKKTQEQEKKTWDQE-KMREEESMREREKKMREEEEM 728
+EQEK QEQE K+W QE+ E+K +EQEKK W QE K+ E+E +RE EK R+E+E
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK--RQEQEE 463
Query: 729 MREQEEKMQEQEE------KMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLW-EH 780
M QEEK++EQEE KM EQE+ + +QEEK+W QEEKM +Q+ ++ EQ+EK+W +
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQEK-IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522
Query: 781 EKMQEQE-KIWEQEEKMRDQEEKMRGQEEKMRGQEEKM------RGQEEKMWGQEEKMWG 833
EK++EQE KI EQEEK+R+QEE M+ QEEKM QEEKM R QEEK+ QEEK+
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 834 QEEKMWGQEEKMWGQEEKM---EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Q+EK+ QEEK+W QEEK+ EE MQ QEEKM EQEEKM QEEKM+EQEEKMR QEEK
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 891 IY 892
++
Sbjct: 643 MW 644
Score = 288 bits (736), Expect = 2e-77
Identities = 181/476 (38%), Positives = 289/476 (60%), Gaps = 43/476 (9%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E+ + R L E + E L+ + ++++ +K+E++ + ++ RK E
Sbjct: 196 EELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV---KELKRKLE 252
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSL-IPGESKDLAGRLHHS-----WHFAGELQR 183
L P L G L VS L E +L RL+ W ++Q
Sbjct: 253 RAKLLLPQQ-QLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
Query: 184 ALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---ELQEKLPLAESE 240
+ + +K E++ ++ + + + E+++++ E +EK+ E
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE-------------MWRQEEELREQEKK 287
E + ++EL+ K+ + + Q + +E+ MWRQEE++REQE+K
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 288 IRKQEEKMWRQEERLREQEGKMREQE-----EKMWRQEKRLREQEKELREQEKELREQKE 342
IR+QE+KMWRQEE++ EQE K+RE+E E+MWRQE+++REQE+ R++EK + EQ++
Sbjct: 432 IREQEKKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK-MHEQEK 489
Query: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402
+R+QEE++ QEEKM +QEEK+REQEEKMWRQEE++ EQE+++REQE+K+R+QEE M EQ
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 403 DERLREKEERMREQEKMWEQVEKMREEK--------KMQEQEKKTRDQEEKMQE-EERIR 453
+E++ E+EE+M+EQEKM Q EK+RE++ K++EQE+K +QEEK++E EE ++
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLWEQEKMQE 508
E+E+KM E+EE M EQEEKMQ+QEE M QEEK W+Q+ RL +Q+EK+ E ++ E
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 153 bits (386), Expect = 8e-37
Identities = 126/411 (30%), Positives = 202/411 (49%), Gaps = 73/411 (17%)
Query: 532 KMWRQEKMREQEDQMWEQEEKMR--------DQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
K RQ K+ E ++Q+ + + D ++K + E T D+++
Sbjct: 53 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQK 112
Query: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
+ + RE + + +R + E + + + + + E + ++ ++ +
Sbjct: 113 ASHQHQEALRRE--LEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS 170
Query: 644 EEKMWEQEEKMWEQQRLPEQKEK----LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
+ E E+ + + QK+K + E K ++ ++ I ++E EK + Q
Sbjct: 171 WKFAGELEQAL---SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 700 EK-KTWDQEKMREEESMREREKKMREEEEMMREQE---------EKMQEQEEKMQEQ--E 747
EK + + EK + +++E ++K+ + ++ +Q+ +++Q K+Q Q E
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 748 EEMW-----EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
E+W +QEEKMW QEEK+ E WE EKI EQEEK+R+QEEK
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQE-----------WE-------EKIQEQEEKIREQEEK 329
Query: 803 MRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK---MEEKMQGQ 859
+R QEEKMR QEE M +EEKM QEE MW +EEKM EE MW +EEK +EEKM Q
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 860 E------------------EKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
E EK +EQE KM QEEK+REQEEK+R QE+K++
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 640 bits (1650), Expect = 0.0
Identities = 369/648 (56%), Positives = 454/648 (70%), Gaps = 112/648 (17%)
Query: 5 PHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSG 64
PHLP HPMMS++TRQ+KLAEAK++ TD+ VGT A+DTKKKKIN+GTNPETTTSG
Sbjct: 31 PHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSG 90
Query: 65 GCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA 124
GCHSPED E+KASHQHQEALRRE+EAQ TIRILTCQKTEL+ ALYYSQ A
Sbjct: 91 GCHSPED----------EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHA 140
Query: 125 ARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA 184
++ E GE++DL RLH SW FAGEL++A
Sbjct: 141 VKQLE--------------------------------GEARDLISRLHDSWKFAGELEQA 168
Query: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEI 244
LSAV+T+ KKADRYIEELTKERDALSLELYRNTIT+EELK+KNA+LQEKL L ESEKSEI
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ--EEKMWRQEERL 302
QLNVKELKRKLERAK LLPQ Q LQ E +EL+ K++ Q E ++W RL
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKLQAQVEENELWN---RL 282
Query: 303 REQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE 362
+Q QEEKMWRQE E++QE+EEK+ EQEE
Sbjct: 283 NQQ------QEEKMWRQE---------------------------EKIQEREEKIQEQEE 309
Query: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
K+REQEEKM RQEE +WE+E +KMR QEE MWE++E++RE EE+M EQEK+ EQ
Sbjct: 310 KIREQEEKMRRQEEMMWEKE-------EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 362
Query: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
EK +EE+K++EQEK+ + + ++EE+IRE+E+K+RE+EE M+EQEEKM +QEE MWE
Sbjct: 363 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWE 422
Query: 483 QEEKEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
QEE+ + EQ+EK+ QE K++EQE+KI EQEEKIR+QEEM ++ +EKM E
Sbjct: 423 QEEE------MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ-----EEKMGE 471
Query: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
QE +M EQE KM++QE+KM R E+K +EQEKK +QEEK+RE+E M M+E+
Sbjct: 472 QEGKMCEQEAKMQEQEEKM----RRQEEKIREQEKKIREQEEKIREQEEM------MQEQ 521
Query: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
EE M EQEEKM EQEEKMQEQEEKM QEEKM+EQE ++ +QEEKM E
Sbjct: 522 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 346 bits (888), Expect = 5e-95
Identities = 219/487 (44%), Positives = 324/487 (66%), Gaps = 51/487 (10%)
Query: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERA 258
I LT ++ L + LY + ++L+ + +L +L + E++ + + + ++A
Sbjct: 120 IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKA 179
Query: 259 KFLLPQV--QTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE 313
+ ++ + + L E++R +EEL+E+ K+ +EK+ E E + ++E +
Sbjct: 180 DRYIEELTKERDALSLELYRNTITDEELKEKNAKL---QEKLQLVESEKSEIQLNVKELK 236
Query: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
K+ R + L +Q+ L+ + L ++ + + Q Q +E ++W + + +QEEKMWR
Sbjct: 237 RKLERAKLLLPQQQ--LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ--QQEEKMWR 292
Query: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM-WEQVEKMRE-EKK 431
QEE++ E+E++++EQE+K+R+QEE+M Q+E + EKEE+MR QE+M WE+ EK+RE E+K
Sbjct: 293 QEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREE------EETMREQEEKMQKQEENMWEQEE 485
M EQEK R+QEEK QEEE+IRE+EK+ +E EE +REQEEK+++QEE M EQEE
Sbjct: 353 MHEQEK-IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411
Query: 486 KEWQQQRLPEQKEKLWEQEK-MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
K + EQ+EK+WEQE+ MQEQEEK+ QEEKIR+QE+ K+REQE+
Sbjct: 412 K------MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEK------------KIREQEE 453
Query: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR-EEERMREREKKMREEEE 603
++ EQEE M++QE+KM +QE +M EQE K +QEEKMR +EE++RE+EKK+RE+EE
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKM----CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509
Query: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
+REQEE MQEQEEKM EQEEKM EQEEKMQEQEEKM QEEKM EQE RL +Q
Sbjct: 510 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQE------VRLRQQ 563
Query: 664 KEKLWEH 670
+EK+ EH
Sbjct: 564 EEKMQEH 570
Score = 345 bits (886), Expect = 8e-95
Identities = 213/502 (42%), Positives = 317/502 (63%), Gaps = 37/502 (7%)
Query: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
E EQK Q + ++ + + R+ +K Q+ + +++ E + RD ++
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 447 QEEERIR-EREKKMR----EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
+ + E E+ + ++++ R EE ++++ E + L E+ KL
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL- 214
Query: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
QEK+Q E + E + +++ + + K + Q++++ + D + ++ + + + Q
Sbjct: 215 -QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
++ E + Q+QE+K W QEEK++E E E ++EQEEK++EQEEKM+
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQERE-------------EKIQEQEEKIREQEEKMRR 320
Query: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
QEE MWE+EEKM+ QEE MWE+EEK+ E EEKM EQ+++ EQ+EK E EK++EQEK QE
Sbjct: 321 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 380
Query: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKM--REEESMREREKKMREEEEMMREQEEKMQEQ 739
QE K+W QE+ K +EQE+K +QE+M +EE M E+E+KM E+EE M+EQEEKM+ Q
Sbjct: 381 QEAKMWRQEE---KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLWEHE-KMQEQEKIWEQEEKMR 797
EEK++EQE+++ EQEEK+ EQEE M EQ+ ++ EQ+ K+ E E KMQ EQEEKMR
Sbjct: 438 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ------EQEEKMR 491
Query: 798 DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
QEEK+R QE+K+R QEEK+R QEE M QEEKMW QEEKM QEEKM ++ EEKM+
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM----QEQEEKMR 547
Query: 858 GQEEKMREQEEKMRGQEEKMRE 879
QEEKMREQE ++R QEEKM+E
Sbjct: 548 RQEEKMREQEVRLRQQEEKMQE 569
Score = 340 bits (873), Expect = 3e-93
Identities = 214/517 (41%), Positives = 335/517 (64%), Gaps = 52/517 (10%)
Query: 238 ESEKSEIQLNVKELKRKLERA--KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
E E+ + + L+R+LE + Q LQ ++ + +++ E + R ++
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 296 ---WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR-EQEKELREQKELREQEEQMQ 351
W+ L + + Q++K R + L ++ L E + +EL+E+ ++Q
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215
Query: 352 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 411
E+ + + ++ +++ +++ R+ ER ++ +Q+++ + + + ++ + + K +
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKLERA-----KLLLPQQQLQAEADHLGKELQSVSAKLQ 270
Query: 412 RMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE-EERIREREKKMREEEETMREQE 470
E+ ++W ++ + +EEK M QE+K +++EEK+QE EE+IRE+E+KMR +EE M E+E
Sbjct: 271 AQVEENELWNRLNQQQEEK-MWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE 329
Query: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
EKM++QEE MWE+EEK + E +EK+ EQEK++EQEEK ++EEKIR+QE+ QE
Sbjct: 330 EKMRRQEEMMWEKEEK------IRELEEKMHEQEKIREQEEKR-QEEEKIREQEKRQEQE 382
Query: 531 KKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKM-REE 588
KMWRQ EK+REQE+++ EQEE M++QE+KM +QEE+M EQE++ +QEEKM R+E
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM----WEQEEEMQEQEEKMRRQE 438
Query: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMW 648
E++RE+EKK+RE+EE +REQEE MQEQEEKM EQE KM EQE KMQEQEEKM QEEK+
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498
Query: 649 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEK 708
EQE+K + EQ+EK+ E E+M MQEQEEK+WEQE EK +++EK
Sbjct: 499 EQEKK------IREQEEKIREQEEM-----MQEQEEKMWEQE--EKMCEQEEK------- 538
Query: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
M+E+E+KMR +EE MREQE ++++QEEKMQE
Sbjct: 539 ------MQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 333 bits (854), Expect = 4e-91
Identities = 223/510 (43%), Positives = 317/510 (62%), Gaps = 48/510 (9%)
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
EQ+ QE RE E +++ ++ EL+ Q +++ + + +
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 157
Query: 371 MWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
W+ L + + Q++K R EE E+D E E++ E+ K++E+
Sbjct: 158 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 217
Query: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---EKMQKQEENMWEQ-EE 485
++ E EK + + ++E +R ER K + +++ E + +++Q + Q EE
Sbjct: 218 LQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Query: 486 KEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEE-MWGQEKKMW-RQEKMREQ 542
E + +Q+EK+W Q EK+QE+EEKI EQEEKIR+QEE M QE+ MW ++EKMR Q
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335
Query: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
E+ MWE+EEK+R+ E+KM +QE K +EQE+K +EEK+RE+E+ +E+E KM +E
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQE-----KIREQEEKR-QEEEKIREQEKRQEQEAKMWRQE 389
Query: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ-RLP 661
E +REQEEK++EQEE MQEQEEKM EQEEKM EQEE+M EQEEKM QEEK+ EQ+ ++
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449
Query: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
EQ+EK+ E E+M MQEQEEK+ EQ E K EQE K +QE E MR +E+K
Sbjct: 450 EQEEKIREQEEM-----MQEQEEKMGEQ---EGKMCEQEAKMQEQE-----EKMRRQEEK 496
Query: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
+RE+E+ +REQEEK++EQEE MQEQEE+MWEQEEKM EQEEKM EQ+ E
Sbjct: 497 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE------------E 544
Query: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMR 811
KM+ QEEKMR+QE ++R QEEKM+
Sbjct: 545 KMR------RQEEKMREQEVRLRQQEEKMQ 568
Score = 286 bits (731), Expect = 8e-77
Identities = 185/464 (39%), Positives = 277/464 (59%), Gaps = 65/464 (14%)
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
E+E+ Q ++ ++E Q + Q+ Q + Q +++ E + + ++
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 521 RDQEEMWGQ-EKKMWRQEKMREQEDQMWEQEEKMRDQ-----------EQKMWDQEERME 568
D + G+ E+ + +++ D+ E+ K RD ++++ ++ +++
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215
Query: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE----------KMQEQEEK 618
+K Q E + + + ++E +R ER K + ++++ E + K+Q Q E+
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Query: 619 M-------QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Q+QEEKMW QEEK+QE+EEK+ EQEEK+ EQEEKM Q+E +WE E
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKM------RRQEEMMWEKE 329
Query: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
EKM+ QEE +WE+E+ K +E E+K +QEK+RE+E R+ E+K+RE+E+ +E
Sbjct: 330 -----EKMRRQEEMMWEKEE---KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QE 380
Query: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
QE KM QEEK++EQEE++ EQEE M EQEEKM EQ+ EK+WE
Sbjct: 381 QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE------------------EKMWE 422
Query: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851
QEE+M++QEEKMR QEEK+R QE+K+R QEEK+ QEE M QEEKM QE KM QE K
Sbjct: 423 QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK 482
Query: 852 M---EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
M EEKM+ QEEK+REQE+K+R QEEK+REQEE M+ QEEK++
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 526
>gi|239750781 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 307
Score = 531 bits (1369), Expect = e-151
Identities = 264/265 (99%), Positives = 264/265 (99%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET
Sbjct: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY
Sbjct: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
Query: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE
Sbjct: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL LAESE
Sbjct: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESE 240
Query: 241 KSEIQLNVKELKRKLERAKFLLPQV 265
KSEIQLNVKELKRKLERAKFLLPQV
Sbjct: 241 KSEIQLNVKELKRKLERAKFLLPQV 265
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 419 bits (1076), Expect = e-117
Identities = 239/445 (53%), Positives = 323/445 (72%), Gaps = 47/445 (10%)
Query: 198 YIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLER 257
YIE+LTKERDALSLELYRNTIT+EELK+KNAELQEKL L ESEKSEIQLNVK+LKRKLER
Sbjct: 191 YIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER 250
Query: 258 AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ--EEKMW-----RQEERLREQEGKMR 310
A+ LLPQ Q LQ E R +EL+ K++ Q E ++W +QEE++ QE K++
Sbjct: 251 AQLLLPQQQ---LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ 307
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKE-LREQEEQMQEQEEKMWEQEEKMREQEE 369
EQEEKM QE ++REQE+++ QE+++ EQ+E +REQE++M QEEK+ EQEEK+REQEE
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE 367
Query: 370 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
KMWRQEE++ REQ++K+++QEE MW Q+E++RE+EE + QEKMW R+E
Sbjct: 368 KMWRQEEKI-------REQDEKIQEQEEEMWRQEEKIREQEE--KRQEKMW------RQE 412
Query: 430 KKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-E 487
KKM+EQ++K R+QEE+M ++EE+IRE E+ M+++EE +RE EEKMQ++EE M EQEEK +
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 488 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKMREQEDQM 546
Q++++ EQ+EK W QEK+ +QEEKIWEQEEK MW QE+KMW Q EKM+EQE++M
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK------MWRQEEKMWEQEEKMQEQEEKM 526
Query: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
QEEKMR+QE ++W QEE+M QEQE + + EE++ + + E E R
Sbjct: 527 QRQEEKMREQEVRLWQQEEKM----QEQEVRLQELEERLGKLGQKAELLGGAGRESGSQR 582
Query: 607 --------EQEEKMQEQEEKMQEQE 623
+ E K QE + Q+Q+
Sbjct: 583 LPTLTPILQVELKSQEAQSLQQQQD 607
Score = 319 bits (817), Expect = 8e-87
Identities = 211/591 (35%), Positives = 341/591 (57%), Gaps = 82/591 (13%)
Query: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER---MWEQDERLREKEERMRE 415
EQ+ K+R + R++ E+ Q+ E E + +++ R W++D+ L E E+ +
Sbjct: 40 EQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQC 99
Query: 416 QEKMWEQVEKMREEKKMQE----QEKKTRDQEEKMQEEERIREREKKMREEEETMREQ-- 469
+E + + +++ +++ KK D+ + ++R++KM E+ T R++
Sbjct: 100 KESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSS-----FKKRQEKMNEKNYTFRKRVV 154
Query: 470 ---------EEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLWEQEKM------------Q 507
E QK+ EN +E + R+ EKL ++ +
Sbjct: 155 IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDE 214
Query: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
E +EK E +EK+R E + + + K + + Q+ +++++ + ++ + + +
Sbjct: 215 ELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV 274
Query: 568 EKKTQEQ--EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
K Q Q E + W+ + +EE KM +EE ++EQEEKM EQE K++EQEEK
Sbjct: 275 SAKLQAQVEENELWNLLNQQQEE--------KMWRQEEKIQEQEEKMCEQELKIREQEEK 326
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLW-EHEKMQEQ-EKMQEQ 682
MW QEEKM EQEEK+ EQE+KMW QEEK+ EQ +++ EQ+EK+W + EK++EQ EK+QEQ
Sbjct: 327 MWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386
Query: 683 EEKIWEQE---------------KMEKKTQEQEKKTWDQEK--MREEESMREREKKMREE 725
EE++W QE + EKK +EQ++K +QE+ R+EE +RE E+ M+++
Sbjct: 387 EEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
EE +RE EEKMQE+EEKMQEQEE++ QEEK+ EQEEK W Q++L +Q+EK+WE E
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE---- 502
Query: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM 845
EK+W QEEKM +QEEKM+ QEEKM+ QEEKMR QE ++W QEEKM QE ++ EE++
Sbjct: 503 -EKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Query: 846 WGQEEKMEEKMQGQEEKMREQ---------EEKMRGQE-EKMREQEEKMRG 886
G+ + E + G + Q + +++ QE + +++Q++ RG
Sbjct: 562 -GKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRG 611
Score = 304 bits (778), Expect = 3e-82
Identities = 194/497 (39%), Positives = 303/497 (60%), Gaps = 71/497 (14%)
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQ-------------TNTLQEEMWRQEEELR 282
L ESE S K+ K L+R F LP + ++ ++ +++E++
Sbjct: 90 LEESEDS------KQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMN 143
Query: 283 EQEKKIRKQE--EKMW----------RQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
E+ RK+ +K W R E L E+ EK +E++
Sbjct: 144 EKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALS 203
Query: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
E + +EL+E+ ++QE+ + ++ +++ + + R+ ER Q+ +Q
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERA-----QLLLPQQ 258
Query: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
+++ + +R+ ++ + + K + E+ ++W + + +EEK M QE+K ++QEEKM E+E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEK-MWRQEEKIQEQEEKMCEQE 317
Query: 451 -RIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQE---- 504
+IRE+E+KM +EE M EQEEK+++QE+ MW QEEK Q++++ EQ+EK+W QE
Sbjct: 318 LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR 377
Query: 505 ----KMQEQEEKIWEQEEKIRDQEE-----MWGQEKKMWRQ-EKMREQEDQMWEQEEKMR 554
K+QEQEE++W QEEKIR+QEE MW QEKKM Q EK+REQE++MW QEEK+R
Sbjct: 378 EQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR 437
Query: 555 DQEQKMWDQEERM---EKKTQEQEKKTWDQEEKM-REEERMREREKKMREEEEMMREQEE 610
+ E+ M DQEE++ E+K QE+E+K +QEEK+ R+EE+++E+E+K +E++++ QEE
Sbjct: 438 ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK-QEE 496
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
K+ EQEEKM QEEKMWEQEEKMQEQEEKM QEEKM EQE ++W+Q+
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE------------ 544
Query: 671 EKMQEQE-KMQEQEEKI 686
EKMQEQE ++QE EE++
Sbjct: 545 EKMQEQEVRLQELEERL 561
Score = 303 bits (777), Expect = 4e-82
Identities = 195/510 (38%), Positives = 322/510 (63%), Gaps = 49/510 (9%)
Query: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
E LK+ L + + ++ S ++ N E+K ++ + + + + T ++ + ++
Sbjct: 101 ESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE-KNYTFRKRVVIKKPW 159
Query: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQ-------EKELREQ 333
LR E +K+ E +E + +M EK+ ++ L + ++EL+E+
Sbjct: 160 LRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEK 219
Query: 334 EKELREQKELREQEE---QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ------EKQ 384
EL+E+ L E E+ Q+ ++ K + ++ ++++ + +RL ++ + Q
Sbjct: 220 NAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQ 279
Query: 385 MREQEQKM-----RDQEERMWEQDERLREKEERMREQE-KMWEQVEKM-REEKKMQEQEK 437
+ +E ++ + QEE+MW Q+E+++E+EE+M EQE K+ EQ EKM R+E+KM EQE+
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 438 KTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW-QQQRLPE 495
K R+QE+KM ++EE+IRE+E+K+RE+EE M QEEK+++Q+E + EQEE+ W Q++++ E
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEE-MWGQEKKMWR-QEKMREQEDQMWEQEEKM 553
Q+EK QEKM QE+K+ EQ+EKIR+QEE MW QE+K+ +E M++QE+++ E EEKM
Sbjct: 400 QEEK--RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 554 RDQEQKMWDQEE---RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
+++E+KM +QEE R E+K QEQE+KTW QE+ +++EE++ E+E+KM +EE M EQEE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE-------------- 656
KMQEQEEKMQ QEEKM EQE ++ +QEEKM EQE ++ E EE++ +
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRE 577
Query: 657 --QQRLPEQKEKLWEHEKMQEQEKMQEQEE 684
QRLP L K QE + +Q+Q++
Sbjct: 578 SGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 201 bits (510), Expect = 3e-51
Identities = 122/346 (35%), Positives = 204/346 (58%), Gaps = 69/346 (19%)
Query: 175 WHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL 234
W ++ + + K R E++ ++ + + + + E++++++ ++QE+
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ- 386
Query: 235 PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEK 294
+EEMWRQEE++REQE+ K++EK
Sbjct: 387 ------------------------------------EEEMWRQEEKIREQEE---KRQEK 407
Query: 295 MWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE-QKELREQEEQMQEQ 353
MWRQE+++REQ+ K+REQEE+MWRQE+++RE E+ +++QE++LRE +++++E+EE+MQEQ
Sbjct: 408 MWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467
Query: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
EEK+ QEEK++EQEEK WRQ E+L +QE+++ EQE+KM QEE+MWEQ+E+++E+EE+M
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQ-EKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM 526
Query: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM 473
+ R+E+KM+EQE + QEEKMQ E+E ++E EE++
Sbjct: 527 Q------------RQEEKMREQEVRLWQQEEKMQ-------------EQEVRLQELEERL 561
Query: 474 QK--QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
K Q+ + +E QRLP L + K QE + +Q+
Sbjct: 562 GKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 139 bits (351), Expect = 9e-33
Identities = 125/453 (27%), Positives = 207/453 (45%), Gaps = 85/453 (18%)
Query: 14 SEKTRQNKLAEA----KKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSP 69
S K RQ K+ E +K+ + W G T + + + + G +
Sbjct: 134 SFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIE 193
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
+ T++ A E + + +E + E Q+ +R++ +K+E++ + +D RK E
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEK-LRLVESEKSEIQLNV---KDLKRKLE 249
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSL-IPGESKDLAGRLHHS-----WHFAGELQR 183
L P L + G L VS L E +L L+ W ++Q
Sbjct: 250 RAQLLLPQQ-QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 184 ALSAVSTRHKKADRYIEELTKERDALSLE----------LYRNTITNEELKKKNAELQEK 233
+ + K E++ ++ + + + ++R E ++K E +EK
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Query: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR---- 289
+ E + E ++E + ++ R + + + Q QE+MWRQE+++REQ++KIR
Sbjct: 369 MWRQEEKIREQDEKIQEQEEEMWRQEEKIRE-QEEKRQEKMWRQEKKMREQDEKIREQEE 427
Query: 290 ------------------------------------KQEEKMWRQEERLREQEGKMREQE 313
QE QEE+++ QE K++EQE
Sbjct: 428 EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE-----QEEKIQRQEEKIQEQE 482
Query: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
EK WRQEK L+++EK + EQEE+M QEEKMWEQEEKM+EQEEKM R
Sbjct: 483 EKTWRQEKLLKQEEK--------------IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
QEE++ EQE ++ +QE+KM++QE R+ E +ERL
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 40.8 bits (94), Expect = 0.006
Identities = 36/201 (17%), Positives = 92/201 (45%), Gaps = 14/201 (6%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL---QEKLPL 236
+L+ + +K E++ ++ + + E T E+L K+ ++ +EK+
Sbjct: 449 KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWR 507
Query: 237 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW 296
E + E + ++E + K++R + + + + +W+QEE+++EQE ++++ EE++
Sbjct: 508 QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVR-----LWQQEEKMQEQEVRLQELEERLG 562
Query: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
+ ++ G RE + + + E + +E + ++Q R +Q ++
Sbjct: 563 KLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQ 622
Query: 357 MWEQEEKM-----REQEEKMW 372
+ +E + R+ K W
Sbjct: 623 LASGKEALPSCSSRKLRAKRW 643
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 416 bits (1069), Expect = e-116
Identities = 238/445 (53%), Positives = 322/445 (72%), Gaps = 47/445 (10%)
Query: 198 YIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLER 257
YIE+LTKERDA SLELYRNTIT+EELK+KNAELQEKL L ESEKSEIQLNVK+LKRKLER
Sbjct: 191 YIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER 250
Query: 258 AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ--EEKMW-----RQEERLREQEGKMR 310
A+ LLPQ Q LQ E R +EL+ K++ Q E ++W +QEE++ QE K++
Sbjct: 251 AQLLLPQQQ---LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ 307
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKE-LREQEEQMQEQEEKMWEQEEKMREQEE 369
EQEEKM QE ++REQE+++ QE+++ EQ+E +REQE++M QEEK+ EQEEK+REQEE
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE 367
Query: 370 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
KMWRQEE++ REQ++K+++QEE MW Q+E++RE+EE + QEKMW R+E
Sbjct: 368 KMWRQEEKI-------REQDEKIQEQEEEMWRQEEKIREQEE--KRQEKMW------RQE 412
Query: 430 KKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-E 487
KKM+EQ++K R+QEE+M ++EE+IRE E+ M+++EE +RE EEKMQ++EE M EQEEK +
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 488 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKMREQEDQM 546
Q++++ EQ+EK W QEK+ +QEEKIWEQEEK MW QE+KMW Q EKM+EQE++M
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK------MWRQEEKMWEQEEKMQEQEEKM 526
Query: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
QEEKMR+QE ++W QEE+M QEQE + + EE++ + + E E R
Sbjct: 527 QRQEEKMREQEVRLWQQEEKM----QEQEVRLQELEERLGKLGQKAELLGGAGRESGSQR 582
Query: 607 --------EQEEKMQEQEEKMQEQE 623
+ E K QE + Q+Q+
Sbjct: 583 LPTLTPILQVELKSQEAQSLQQQQD 607
Score = 319 bits (818), Expect = 6e-87
Identities = 215/590 (36%), Positives = 341/590 (57%), Gaps = 80/590 (13%)
Query: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER---MWEQDERLREKEERMRE 415
EQ+ K+R + R++ E+ Q+ E E + +++ R W++D+ L E E+ +
Sbjct: 40 EQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQC 99
Query: 416 QEKMWEQVEKMREEKKMQE----QEKKTRDQEEKMQEEERIREREKKMREEEETMREQ-- 469
+E + + +++ +++ KK D+ + ++R++KM E+ T R++
Sbjct: 100 KESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSS-----FKKRQEKMNEKNYTFRKRVV 154
Query: 470 ---------EEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
E QK+ EN +E + R+ EKL +E++ E
Sbjct: 155 IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKL-----TKERDAPSLELYRN 209
Query: 520 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD------------QEQKMWDQEERM 567
EE+ +EK QEK+R E + E + ++D +Q++ + +R+
Sbjct: 210 TITDEEL--KEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRL 267
Query: 568 EKKTQEQEKKTWDQEEKMREEERM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
K+ Q K Q E+ + +++E+KM +EE ++EQEEKM EQE K++EQEEKM
Sbjct: 268 GKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327
Query: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLW-EHEKMQEQ-EKMQEQE 683
W QEEKM EQEEK+ EQE+KMW QEEK+ EQ +++ EQ+EK+W + EK++EQ EK+QEQE
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE 387
Query: 684 EKIWEQE---------------KMEKKTQEQEKKTWDQEK--MREEESMREREKKMREEE 726
E++W QE + EKK +EQ++K +QE+ R+EE +RE E+ M+++E
Sbjct: 388 EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQE 447
Query: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
E +RE EEKMQE+EEKMQEQEE++ QEEK+ EQEEK W Q++L +Q+EK+WE E
Sbjct: 448 EKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE----- 502
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
EK+W QEEKM +QEEKM+ QEEKM+ QEEKMR QE ++W QEEKM QE ++ EE++
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL- 561
Query: 847 GQEEKMEEKMQGQEEKMREQ---------EEKMRGQE-EKMREQEEKMRG 886
G+ + E + G + Q + +++ QE + +++Q++ RG
Sbjct: 562 GKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRG 611
Score = 305 bits (780), Expect = 2e-82
Identities = 194/497 (39%), Positives = 303/497 (60%), Gaps = 71/497 (14%)
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQ-------------TNTLQEEMWRQEEELR 282
L ESE S K+ K L+R F LP + ++ ++ +++E++
Sbjct: 90 LEESEDS------KQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMN 143
Query: 283 EQEKKIRKQE--EKMW----------RQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
E+ RK+ +K W R E L E+ EK +E++
Sbjct: 144 EKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPS 203
Query: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
E + +EL+E+ ++QE+ + ++ +++ + + R+ ER Q+ +Q
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERA-----QLLLPQQ 258
Query: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
+++ + +R+ ++ + + K + E+ ++W + + +EEK M QE+K ++QEEKM E+E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEK-MWRQEEKIQEQEEKMCEQE 317
Query: 451 -RIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQE---- 504
+IRE+E+KM +EE M EQEEK+++QE+ MW QEEK Q++++ EQ+EK+W QE
Sbjct: 318 LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR 377
Query: 505 ----KMQEQEEKIWEQEEKIRDQEE-----MWGQEKKMWRQ-EKMREQEDQMWEQEEKMR 554
K+QEQEE++W QEEKIR+QEE MW QEKKM Q EK+REQE++MW QEEK+R
Sbjct: 378 EQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR 437
Query: 555 DQEQKMWDQEERM---EKKTQEQEKKTWDQEEKM-REEERMREREKKMREEEEMMREQEE 610
+ E+ M DQEE++ E+K QE+E+K +QEEK+ R+EE+++E+E+K +E++++ QEE
Sbjct: 438 ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK-QEE 496
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
K+ EQEEKM QEEKMWEQEEKMQEQEEKM QEEKM EQE ++W+Q+
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE------------ 544
Query: 671 EKMQEQE-KMQEQEEKI 686
EKMQEQE ++QE EE++
Sbjct: 545 EKMQEQEVRLQELEERL 561
Score = 302 bits (773), Expect = 1e-81
Identities = 195/510 (38%), Positives = 321/510 (62%), Gaps = 49/510 (9%)
Query: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
E LK+ L + + ++ S ++ N E+K ++ + + + + T ++ + ++
Sbjct: 101 ESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNE-KNYTFRKRVVIKKPW 159
Query: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK-------RLREQEKELREQ 333
LR E +K+ E +E + +M EK+ ++ R ++EL+E+
Sbjct: 160 LRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEK 219
Query: 334 EKELREQKELREQEE---QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ------EKQ 384
EL+E+ L E E+ Q+ ++ K + ++ ++++ + +RL ++ + Q
Sbjct: 220 NAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQ 279
Query: 385 MREQEQKM-----RDQEERMWEQDERLREKEERMREQE-KMWEQVEKM-REEKKMQEQEK 437
+ +E ++ + QEE+MW Q+E+++E+EE+M EQE K+ EQ EKM R+E+KM EQE+
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 438 KTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW-QQQRLPE 495
K R+QE+KM ++EE+IRE+E+K+RE+EE M QEEK+++Q+E + EQEE+ W Q++++ E
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEE-MWGQEKKMWR-QEKMREQEDQMWEQEEKM 553
Q+EK QEKM QE+K+ EQ+EKIR+QEE MW QE+K+ +E M++QE+++ E EEKM
Sbjct: 400 QEEK--RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 554 RDQEQKMWDQEE---RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
+++E+KM +QEE R E+K QEQE+KTW QE+ +++EE++ E+E+KM +EE M EQEE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE-------------- 656
KMQEQEEKMQ QEEKM EQE ++ +QEEKM EQE ++ E EE++ +
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRE 577
Query: 657 --QQRLPEQKEKLWEHEKMQEQEKMQEQEE 684
QRLP L K QE + +Q+Q++
Sbjct: 578 SGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 201 bits (510), Expect = 3e-51
Identities = 122/346 (35%), Positives = 204/346 (58%), Gaps = 69/346 (19%)
Query: 175 WHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL 234
W ++ + + K R E++ ++ + + + + E++++++ ++QE+
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ- 386
Query: 235 PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEK 294
+EEMWRQEE++REQE+ K++EK
Sbjct: 387 ------------------------------------EEEMWRQEEKIREQEE---KRQEK 407
Query: 295 MWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE-QKELREQEEQMQEQ 353
MWRQE+++REQ+ K+REQEE+MWRQE+++RE E+ +++QE++LRE +++++E+EE+MQEQ
Sbjct: 408 MWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467
Query: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
EEK+ QEEK++EQEEK WRQ E+L +QE+++ EQE+KM QEE+MWEQ+E+++E+EE+M
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQ-EKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM 526
Query: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM 473
+ R+E+KM+EQE + QEEKMQ E+E ++E EE++
Sbjct: 527 Q------------RQEEKMREQEVRLWQQEEKMQ-------------EQEVRLQELEERL 561
Query: 474 QK--QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
K Q+ + +E QRLP L + K QE + +Q+
Sbjct: 562 GKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 140 bits (352), Expect = 7e-33
Identities = 125/453 (27%), Positives = 207/453 (45%), Gaps = 85/453 (18%)
Query: 14 SEKTRQNKLAEA----KKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSP 69
S K RQ K+ E +K+ + W G T + + + + G +
Sbjct: 134 SFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIE 193
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
+ T++ A E + + +E + E Q+ +R++ +K+E++ + +D RK E
Sbjct: 194 KLTKERDAPSLELYRNTITDEELKEKNAELQEK-LRLVESEKSEIQLNV---KDLKRKLE 249
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSL-IPGESKDLAGRLHHS-----WHFAGELQR 183
L P L + G L VS L E +L L+ W ++Q
Sbjct: 250 RAQLLLPQQ-QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 184 ALSAVSTRHKKADRYIEELTKERDALSLE----------LYRNTITNEELKKKNAELQEK 233
+ + K E++ ++ + + + ++R E ++K E +EK
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Query: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR---- 289
+ E + E ++E + ++ R + + + Q QE+MWRQE+++REQ++KIR
Sbjct: 369 MWRQEEKIREQDEKIQEQEEEMWRQEEKIRE-QEEKRQEKMWRQEKKMREQDEKIREQEE 427
Query: 290 ------------------------------------KQEEKMWRQEERLREQEGKMREQE 313
QE QEE+++ QE K++EQE
Sbjct: 428 EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE-----QEEKIQRQEEKIQEQE 482
Query: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
EK WRQEK L+++EK + EQEE+M QEEKMWEQEEKM+EQEEKM R
Sbjct: 483 EKTWRQEKLLKQEEK--------------IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
QEE++ EQE ++ +QE+KM++QE R+ E +ERL
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 40.8 bits (94), Expect = 0.006
Identities = 36/201 (17%), Positives = 92/201 (45%), Gaps = 14/201 (6%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL---QEKLPL 236
+L+ + +K E++ ++ + + E T E+L K+ ++ +EK+
Sbjct: 449 KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWR 507
Query: 237 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW 296
E + E + ++E + K++R + + + + +W+QEE+++EQE ++++ EE++
Sbjct: 508 QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVR-----LWQQEEKMQEQEVRLQELEERLG 562
Query: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
+ ++ G RE + + + E + +E + ++Q R +Q ++
Sbjct: 563 KLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQ 622
Query: 357 MWEQEEKM-----REQEEKMW 372
+ +E + R+ K W
Sbjct: 623 LASGKEALPSCSSRKLRAKRW 643
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 403 bits (1035), Expect = e-112
Identities = 223/447 (49%), Positives = 357/447 (79%), Gaps = 21/447 (4%)
Query: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277
ITNEELK+KNAELQE+L L E+EKSEIQL++KELKRKLE K LPQ + ++ Q
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ------EGQVREQ 57
Query: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
E ++REQE ++R+QE ++ QE ++REQEG++REQE ++ QE ++REQE ++REQE ++
Sbjct: 58 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 117
Query: 338 REQK-ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 396
REQ+ ++REQE Q++EQE ++ EQE ++REQE ++ QE ++ EQE Q+REQE ++R+QE
Sbjct: 118 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 177
Query: 397 ERMWEQDERLREKEERMREQE-KMWEQVEKMRE-EKKMQEQEKKTRDQEEKMQ-EEERIR 453
++ EQ+ ++RE+E +M EQE +M EQ E+M E E++MQ+QE++ +QEE+M+ +EE++
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQEKMQEQEEK 512
E+E++++++EE +++QEE+M+KQEE M EQEE+ Q++++ +QKE+ ++E+ EQEE+
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ EQEE++R+QEE ++ +E+MREQE+QM +QEE+M +Q+++MW+Q+E+M K
Sbjct: 298 MREQEEQMREQEEQMREQ-----EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK--- 349
Query: 573 EQEKKTWDQEEKM-REEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
QE++ +QEE+M ++EE++R++E++MR++EE MR+QEE+M++QEE+M EQ+E+M EQ+E
Sbjct: 350 -QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKE 408
Query: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
+M+EQEE+M EQ+E+M +QEE M EQ+
Sbjct: 409 QMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 351 bits (901), Expect = 2e-96
Identities = 214/482 (44%), Positives = 336/482 (69%), Gaps = 53/482 (10%)
Query: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
+E L+EK ++E+ ++ E EK + ++E ++K + + +E ++RE+E ++RE+
Sbjct: 6 NEELKEKNAELQEELQLVE-TEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQ 64
Query: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIR 521
E +REQE ++++QE + EQE + + EQ+ ++ EQE +++EQE ++ EQE ++R
Sbjct: 65 EGQVREQEGQVREQEGQVREQEGQ------VREQEGQVREQEGQVREQEGQVREQEGQVR 118
Query: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
+QE GQ +REQE Q+ EQE ++R+QE ++ +QE ++ +EQE + +Q
Sbjct: 119 EQE---GQ---------VREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQ 162
Query: 582 EEKMREEE-RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E ++RE+E ++RE+E ++RE+E +REQE +M EQE +M EQEE+M EQEE+MQ+QEE+M
Sbjct: 163 EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM 222
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
EQEE+M +QEE+M EQ+ EQ +K E + QE E+M++QEE++ EQE+ ++ +EQ
Sbjct: 223 GEQEEQMRKQEEQMGEQE---EQVQKQEEQVQKQE-EQMRKQEEQMREQEEQMREQEEQM 278
Query: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
K +E+ +EE E+E++MRE+EE MREQEE+M+EQEE+M+EQEE+M +QEE+MWEQ
Sbjct: 279 LK--QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336
Query: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
+E+MWEQ+ E++W+QEE+M +QEE+M+ QEE++R QEE+MR Q
Sbjct: 337 KEQMWEQK------------------EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQ 378
Query: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
EE+M QEE+M QEE+M Q+E+M Q+E+M E QEE+M EQ+E+MR QEE M EQ
Sbjct: 379 EEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE----QEEQMGEQKEQMRKQEEHMGEQ 434
Query: 881 EE 882
+E
Sbjct: 435 KE 436
Score = 344 bits (882), Expect = 2e-94
Identities = 205/473 (43%), Positives = 338/473 (71%), Gaps = 48/473 (10%)
Query: 300 ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
E L+E+ +++E+ + + ++ ++ KEL+ ++L K QE Q++EQE ++ E
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELK---RKLETDKIPLPQEGQVREQEGQVRE 63
Query: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
QE ++REQE ++ QE ++ EQE Q+REQE ++R+QE ++ EQ+ ++RE+E ++REQE
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEE-RIREREKKMREEEETMREQEEKMQKQEE 478
+ +E +++EQE + R+QE +++E+E ++RE+E ++RE+E +REQE ++++QE
Sbjct: 124 VRE-----QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 479 NMWEQEEKEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
+ EQE + + EQ+ ++ EQE +M EQEE++ EQEE+++ QEE G++ +E
Sbjct: 179 QVREQEGQ------VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ-----EE 227
Query: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREK 596
+MR+QE+QM EQEE+++ QE+++ QEE+M K QEE+MRE EE+MRE+E+
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK-----------QEEQMREQEEQMREQEE 276
Query: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
+M +++E EQEE+ EQEE+M+EQEE+M EQEE+M+EQEE+M EQEE+M +QEE+MWE
Sbjct: 277 QMLKQKEQT-EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 657 Q-QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Q +++ EQKE++W+ E E+M EQEE++ +QE+ +K +EQ +K +EE M
Sbjct: 336 QKEQMWEQKEQMWKQE-----EQMGEQEEQMQKQEEQVRKQEEQMRK--------QEEQM 382
Query: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
R++E++MR++EE M EQ+E+M EQ+E+M+EQEE+M EQ+E+M +QEE M EQ+
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 315 bits (808), Expect = 9e-86
Identities = 197/502 (39%), Positives = 340/502 (67%), Gaps = 78/502 (15%)
Query: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
R +EL+E+ EL+E+ +L E E+ E + ++E + K+ + L QE
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKS---------EIQLHIKELKRKLETDKIPL-PQEG 52
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Q+REQE ++R+QE ++ EQ+ ++RE+E ++REQE + +E +++EQE + R+QE
Sbjct: 53 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-----QEGQVREQEGQVREQE 107
Query: 444 EKMQEEE-RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
+++E+E ++RE+E ++RE+E +REQE ++++QE + EQE + + EQ+ ++ E
Sbjct: 108 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ------VREQEGQVRE 161
Query: 503 QE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
QE +++EQE ++ EQE ++R+QE GQ +REQE QM EQE +M +QE++M
Sbjct: 162 QEGQVREQEGQVREQEGQVREQE---GQ---------VREQEGQMGEQEGQMGEQEEQMG 209
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
+QEE+M+K +EE+M E+E++MR++EE M EQEE++Q+QEE++Q+
Sbjct: 210 EQEEQMQK-----------------QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK 252
Query: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM--QEQEKM 679
QEE+M +QEE+M+EQEE+M EQEE+M +Q+E+ ++++ EQ+E++ E E+ +++E+M
Sbjct: 253 QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQM 312
Query: 680 QEQEEKIWEQE----KMEKKTQEQEKKTWDQEKM--REEESMREREKKMREEEEMMREQE 733
+EQEE++ EQE K E++ EQ+++ W+Q++ ++EE M E+E++M+++EE +R+QE
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE 372
Query: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
E+M++QEE+M++QEE+M +QEE+M EQ+E+M EQ +E++ EQE
Sbjct: 373 EQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ------------------KEQMREQE 414
Query: 794 EKMRDQEEKMRGQEEKMRGQEE 815
E+M +Q+E+MR QEE M Q+E
Sbjct: 415 EQMGEQKEQMRKQEEHMGEQKE 436
Score = 300 bits (768), Expect = 4e-81
Identities = 177/409 (43%), Positives = 294/409 (71%), Gaps = 16/409 (3%)
Query: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
+P + +++ + QEE + EK Q + ++K+ + QE Q+ EQE +
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 553 MRDQEQKMWDQE---ERMEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEEEMMREQ 608
+R+QE ++ +QE E + +EQE + +QE ++RE+E ++RE+E ++RE+E +REQ
Sbjct: 61 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ-RLPEQKEKL 667
E +++EQE +++EQE ++ EQE +++EQE ++ EQE ++ EQE ++ EQ+ ++ EQ+ ++
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 180
Query: 668 WEHE-KMQEQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
E E +++EQE +M EQE ++ EQE+ + +EQ +K +++ +EE MR++E++M E+
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ-EEQMGEQEEQMRKQEEQMGEQ 239
Query: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
EE +++QEE++Q+QEE+M++QEE+M EQEE+M EQEE+M +Q+ EQ+E+ E E
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQE---- 295
Query: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM 845
E++ EQEE+MR+QEE+MR QEE+MR QEE+M QEE+MW Q+E+MW Q+E+MW QEE+M
Sbjct: 296 -EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Query: 846 WGQEEKM---EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
QEE+M EE+++ QEE+MR+QEE+MR QEE+MR+QEE+M Q+E++
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Score = 236 bits (603), Expect = 5e-62
Identities = 134/318 (42%), Positives = 227/318 (71%), Gaps = 29/318 (9%)
Query: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277
+ +E + + E Q + + + E Q+ +E + + + + + Q + +M Q
Sbjct: 145 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQ 204
Query: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
EE++ EQE++++KQEE+M QEE++R+QE +M EQEE++ +QE+++++QE+++R+QE+++
Sbjct: 205 EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQM 264
Query: 338 REQKE-LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 396
REQ+E +REQEEQM +Q+E+ EQEE+ EQEE+M QEE++ EQE+QMREQE++MR+QE
Sbjct: 265 REQEEQMREQEEQMLKQKEQT-EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 397 ERMWEQDERLREKEERMREQ-EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ-EEERIRE 454
E+M +Q+E++ E++E+M EQ E+MW+Q E+M E QEE+MQ +EE++R+
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGE-------------QEEQMQKQEEQVRK 370
Query: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 514
+E++MR++EE MR+QEE+M+KQEE M EQ+E+ +Q +E+M+EQEE++
Sbjct: 371 QEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ------------KEQMREQEEQMG 418
Query: 515 EQEEKIRDQEEMWGQEKK 532
EQ+E++R QEE G++K+
Sbjct: 419 EQKEQMRKQEEHMGEQKE 436
Score = 159 bits (402), Expect = 1e-38
Identities = 86/262 (32%), Positives = 174/262 (66%), Gaps = 15/262 (5%)
Query: 162 GESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNE 221
G+ ++ G++ GE + + + +K + E++ ++ + + + + E
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE---EQMGEQEEQMRKQEEQMGEQEE 241
Query: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281
+++K+ ++Q++ ++ +++ ++++ + E+ +L Q + +E+ QEE++
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQ---MLKQKEQTEQEEQTGEQEEQM 298
Query: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341
REQE+++R+QEE+M QEE++REQE +M +QEE+MW Q++++ EQ++++ +QE+++ EQ
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQ- 357
Query: 342 ELREQEEQMQE-----QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 396
E++ Q QE QEE+M +QEE+MR+QEE+M +QEE++ EQ++QM EQ+++MR+QE
Sbjct: 358 ---EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQE 414
Query: 397 ERMWEQDERLREKEERMREQEK 418
E+M EQ E++R++EE M EQ++
Sbjct: 415 EQMGEQKEQMRKQEEHMGEQKE 436
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 335 bits (858), Expect = 1e-91
Identities = 218/752 (28%), Positives = 448/752 (59%), Gaps = 77/752 (10%)
Query: 189 STRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNV 248
S ++ ++ +L +ER LY E+L+K+ LQE E+ E+Q
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE-------EEEELQREE 917
Query: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR---EQEKKIRKQEEKMWRQEERLREQ 305
+E +R+ E+ + + Q +E++ R+E E R E+E++ RK ++ ++E+ L E+
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 306 EGKMREQE-EKMWRQEKRLREQEKELREQEKELREQKE----LREQEEQMQEQEEKMWEQ 360
K R QE EK +R+E+ L+++E++L +E+E R ++E R+++E QE+E+ + E+
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 361 EEKMREQE-EKMWRQEERLWEQEKQM--REQEQKMRDQEERMWEQDERLREKEERMREQE 417
EK R QE E+ +R+EE L ++E+Q+ E+E + R + ER + ++E L+++EE++ +E
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI--REREKKMREEEETMREQEEKMQK 475
E+++ QE+E++ R++EE QEEE++ EREK+ R+E E +EE++Q+
Sbjct: 1098 P---------EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 476 QEENMWEQEEKEWQQQRLPEQ---KEKLWEQEKM---QEQEEKIWEQEEKIRDQEEMWGQ 529
+EE + +E ++ ++Q L Q +E+L ++E+ +EQE++ E+E + R++EE+ Q
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 530 EKKM-WRQEKMREQEDQMWEQEE-----------KMRDQEQ--KMWDQEERMEKKTQEQE 575
++K +R E R WE E+ K R+ EQ ++ D + R + Q+ +
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 576 KKTWDQEEKMREEERMR--EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE-- 631
+Q+E+ RE+ER R +R++ EEE++ RE++++ + ++ K QE+++ + E+ E
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 632 -KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE---KMQEQEEKIW 687
+ QE + K E+E+ + E+EE+ +Q ++++ + E+++ QE K E+E+++
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQ----ERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM--REQEEKMQEQEEKMQE 745
QE+ E+K ++E++ QE RE++ ++R++K REEE+ + +E++ K +E+E++++
Sbjct: 1385 RQER-ERKFLKEEQQLRCQE--REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 746 QEEE---MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
QE E + E+++ E+ K E+++L +++E+ H + + K E+E+++R QE
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH-RQERDRKFLEEEQQLRRQERD 1500
Query: 803 MRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK 862
+ +E+++R QE + + EE +++ Q ++ + QEE+ ++E+ +++ Q ++ K
Sbjct: 1501 RKFREQELRSQEPERKFLEE----EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 863 MREQEEKMRGQEEKM---REQEEKMRGQEEKI 891
RE+E+ + +EE+ +E++ K R +E+K+
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Score = 323 bits (828), Expect = 4e-88
Identities = 251/829 (30%), Positives = 450/829 (54%), Gaps = 124/829 (14%)
Query: 172 HHSWHFAGELQ-RALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE--LKKKNA 228
H + F E Q R + R K + ++ + +D + E E L+K+
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 229 ELQEKLPLAESEKSEIQLNVKELKRK-LERAKFLLPQVQTNTLQEEMWR--QEEELREQE 285
+LQE+ P + E E + +++L+R+ L R + Q Q +E+ R QEEE REQ+
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 286 KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE----LREQEKELREQK 341
++ R+Q+E+ +QEER REQ+ + REQEE+ +Q +R +E+E+ REQE+E REQ+
Sbjct: 319 EERREQQERREQQEER-REQQLR-REQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 342 ELREQE---EQMQEQEEKMWEQEEKMREQE---EKMWRQEERLWEQEKQMREQEQKMRDQ 395
REQ+ EQ +E+++ +++ REQ+ E+ R+E++L +++ REQE++ +Q
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE----QEKKTRDQEEKMQEEER 451
+ +++RL+ ++E R+ K E+ E+ +E++ Q+ QE++ R++ K++EEER
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ-- 509
RE++ R E++ REQEE+ +E+ + QEE+E QQRL +++ EQE+ +EQ
Sbjct: 497 ---REQQERREQQLRREQEER---REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 510 ---EEKIWEQEEK----IRDQEEMWGQ----EKKMWRQEKMREQEDQMWEQEEKMRDQEQ 558
EEK EQE + R+QEE Q E++ +Q REQE+++ E++++ +E
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL---EQRLKREEV 607
Query: 559 KMWDQEERMEK----------------KTQEQEKKTWDQ---EEKMREEERMREREKKMR 599
+ +QEER E+ K++EQE++ Q E++ R E+R++ E++ R
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 600 EEEEMMREQEEKMQEQEEKMQEQEE-------------------------------KMWE 628
E+ + RE EE+ +EQE +EQE+ + E
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 629 QEEKMQEQEEKMWEQE-EKMWEQEEKMWEQQRLPEQKEKL---WEHEKMQEQEK------ 678
+ + QEQEEK +E E W++EE+ QQ+ EQ+ W+ E+ E+ +
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 679 --MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM--REQEE 734
++EQ E+ E+ +++ Q + ++E+ R + RE+E + EEEE + RE+ +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 735 KMQEQEEKMQEQEEEMWEQEEK-----MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
++QE+E+ +QE +E QE++ W+ EE+ ++ K L E + ++Q
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 790 WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE----------EKMWGQEEKMW 839
E+EE R++ EK R QE++ + +EE+ QEE+ +E E+ + +++K+
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 840 GQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
+EE++ G EE + + Q +E+K RE+EE + +E+ +RE+ EK R QE
Sbjct: 968 QKEEQLLG-EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Score = 322 bits (826), Expect = 8e-88
Identities = 219/796 (27%), Positives = 459/796 (57%), Gaps = 108/796 (13%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSE-----IQ 245
RH++ ++ +E ++R E R+ + EE +++ + + K L ++ E ++
Sbjct: 433 RHEQ--KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 246 LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ-----EKKIRKQEEKMWRQEE 300
L +E + + ER + L + Q ++ + RQEEE R Q E+++R+++E+ R+E+
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE--RREQ 548
Query: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQ--------- 351
L+ +E K EQE + R ++ E+ +L ++E+E R+Q+ REQEE+++
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 352 -----EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
E+ E+ ++EE E+ +++ + EE+ +++Q+R ++Q+ R+Q + E++ERL
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 407 -----REKEERMREQEKMWEQVEKMRE--------------------EKKMQEQEKKTRD 441
RE EE REQE E+ E+ RE + K+ + +K
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 442 QEEKMQEEERIREREKKMR--EEEETMREQEEKMQKQEEN-MWEQEEK-EWQQQRLP--- 494
Q + ++EE+ R RE +++ EEE R+Q+E+ Q+++ W+ EEK E +QRL
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 495 ---EQKEKLWEQEKMQEQEEKIW-EQEEKIRDQEEMWGQEKKMW------------RQEK 538
EQ+E+ E+ Q++E++ E+EEK + + + +EK++ R ++
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 539 MREQEDQMWEQEEKMRDQEQKM-----WDQEERMEKKTQEQEKKTWDQEEKMREEERMRE 593
++E+ED + E +E+ R QEQ+ W EE +++ K QE+ +E++ ++E
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 594 REKKMREEEEMMR---EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE-EKMWEQEEKMWE 649
E++++ EE R EQE + +E+E+ QE+E+ + E+ EK + QE E+ + +++K+ +
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM 709
+EE++ ++ PE++ + +K +E+E++Q++EE++ +E+ +++ QE E++ ++++
Sbjct: 969 KEEQLLGEE--PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 710 REEES-----------MREREKKMREEEEMMREQEEKMQEQEEKMQEQE-EEMWEQEEKM 757
++EE ++ERE++ REEEE+ +E+E+ + E+ E + QE E + +EE++
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 758 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK-MRDQEEKMRGQE-EKMRGQEE 815
++EE++ ++ PE++ + + +E+E++ ++EE+ +R++ EK R QE E+ +EE
Sbjct: 1087 QQEEEQLLREE--PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 816 KMRGQEEKMWGQE-EKMWGQE-EKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873
+++ +EE++ +E EK QE E+ + +EE++ +EE++ ++ ++EK R++ E+ +
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL---LREEQEKRRQERERQYRE 1201
Query: 874 EEKMREQEEKMRGQEE 889
EE+++ Q+ K R ++E
Sbjct: 1202 EEELQRQKRKQRYRDE 1217
Score = 320 bits (820), Expect = 4e-87
Identities = 233/812 (28%), Positives = 460/812 (56%), Gaps = 126/812 (15%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
R ++ +R + L +E + LE + LK+++ E + + LAE E+ + + +K
Sbjct: 648 RREQQERREQRLKREEEEERLE--------QRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 251 LKRKLE-----RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL--R 303
K + A +V + ++E R+ +E ++EK+ R++ E W++EER +
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE--QEEKRRRRESELQWQEEERAHRQ 757
Query: 304 EQEGKMREQEEKMWRQEKR-------------LREQ-EKELREQEKELREQKELREQEEQ 349
+QE + R W+ E++ LREQ E++LR +E++ REQ+ L E+EE+
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 350 MQ--------EQEEKMWEQEEKM--REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 399
Q E+E + E+EE++ RE+ +++ +E+ L E +++ R QEQ+ RDQ+ R
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR-RDQKWRW 876
Query: 400 WEQDERLREK----------EERMREQEKMWEQVEKM----REEKKMQEQEKKTRDQEEK 445
++ER R + E+ +EQ+ + E+ E++ RE+++ QEQE++ R++E+
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Query: 446 MQEEERI--REREKKMREEEETMREQEEKMQKQEENMW-EQEEKEWQQQRLPEQKEKLWE 502
QEEE++ EREK+ R+E E +++K+Q++EE + E+ EK +Q+R + +E E
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE---E 993
Query: 503 QEKMQEQEEKIWEQEEKIRDQE---------EMWGQEKKMWRQEK----MREQEDQMWEQ 549
+E QE+E+ + E+ EK R QE E+ +E+++ R+E+ ++E+E Q E+
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 550 EEKMRDQEQKMWDQEE-----RMEKKTQEQEKKTWDQEEKMREE---ERMREREKKMREE 601
EE +++EQ + ++ E +E++ +++E+ ++E+ +REE R +ERE++ REE
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113
Query: 602 EEMMREQEEKMQEQEEKMQEQE-EKMWEQEEKMQEQEEKMWEQE---EKMWEQEEKMWEQ 657
EE+ +E+E+ ++E+ EK + QE E+ + +EE++Q++EE++ +E + E E + E+
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 658 QRLPEQKEKLWEHE---KMQEQEKMQEQEEKIWEQEKMEKKTQEQE----KKTWDQEKM- 709
+ L +++E+L E + QE+E+ +EE++ Q++ ++ E + K W+ EK
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 710 -----------REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
RE E R+ E + + ++ + + EQ+E+ +EQE W+Q ++ +
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 759 EQEEKMWEQQ---------RLPEQKEKLWE--HEKMQEQE---KIWEQEEKMRDQEEK-M 803
+EE++ ++ + E+K+ L E EK + QE K E+E+ ++++EE+ +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 804 RGQEEKMRGQEEKMRGQEE--KMWGQEEKMWGQE-EKMWGQEEKMWGQEEKMEEKMQGQE 860
R QE + +EE++R QE+ K +E+++ QE E+ + +EE+ +E+ ++ Q ++
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 861 EKMREQEEKMRGQE--EKMREQEEKMRGQEEK 890
K RE+E+++ QE K RE+E+++R QE +
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Score = 320 bits (820), Expect = 4e-87
Identities = 218/763 (28%), Positives = 447/763 (58%), Gaps = 120/763 (15%)
Query: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
E+ ++ L + PL E E QL +E +++ +R LP+ + ++E R++
Sbjct: 775 EKSERGRQRLSARPPLREQR--ERQLRAEERQQREQR---FLPEEE----EKEQRRRQRR 825
Query: 281 LREQEKKIRKQEEKMWRQE--ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
RE+E + ++EE++ R+E ++L+E+E ++E +E+ QE+R ++ + E+E++ R
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885
Query: 339 E---------QKELREQEEQMQEQEEKMW--EQEEKMREQEEKMWRQEERLWEQEKQM-- 385
Q++LR++++ +QE+EE++ E+E++ R+++E+ +R+EE+L ++E+Q+
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
E+E++ R + ER + +D++L++KEE++ +E E+++ QE+EKK R++EE
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEP---------EKRRRQEREKKYREEEEL 996
Query: 446 MQEEERI--REREKKMR---------------EEEETMREQEEKMQKQEENMWEQEEKEW 488
QEEE++ EREK+ R EEE+ +RE+ EK + QE +EE+E
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 489 QQ---QRLPEQKE--KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
QQ Q L E++E + E E+ +EE++ ++EE++ +E + ++ R+ + RE+E
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP--EKRRRQERERQCREEE 1114
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE---ERMREREKKMRE 600
+ E+E+ +R++ +K QE +E++ +E+E+ ++E+ +REE R +E E++ RE
Sbjct: 1115 ELQQEEEQLLREEREKRRRQE--LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK--------------MWEQEEK 646
EEE+ +E+E+ ++E++EK +++ E+ + +EE++Q Q+ K WE E++
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 647 MWEQEEKMWEQQRLPEQKEKL-------------WEHEKMQEQEKMQEQEEKIW------ 687
++ K++ + R EQ +L +H ++QE+ +EQE + W
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 688 --EQEKMEKKTQE---------QEKKTWDQEKMREEESMREREKKMREEEEMMREQEE-- 734
E+E++E++ Q+ QE+K +E+ E+ +E ++K REEE++++E+EE
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 735 -KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM----QEQEKI 789
+ QE++ K +E+E EQ K E+E+++ Q+R +++ L E +++ +EQ+
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER---ERKFLKEEQQLRCQEREQQLR 1409
Query: 790 WEQEEKMRDQEEKMRGQE--EKMRGQEEKMRGQE-EKMWGQEEKMWGQE-EKMWGQEEKM 845
+++ K R++E+++ QE K R +E+++R QE E+ + +EE+ QE + + +EE++
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 846 WGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
+ E+ + Q ++ K E+E+++R QE + +E+++R QE
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Score = 320 bits (819), Expect = 5e-87
Identities = 243/872 (27%), Positives = 470/872 (53%), Gaps = 169/872 (19%)
Query: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYR----NTITNEELKKKNAELQEKLPLA 237
QR L + +K +R +EL +ER + R + ++ +++ + +E+
Sbjct: 268 QRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 238 ESEKSEIQLNVKELKRKLE-RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQE---- 292
E + + + ++L+R+ E R + L + Q +E+ R+E+E +E+++R+++
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 293 EKMWRQEERLREQEGKMREQE---EKMWRQEKRLREQEKELREQEKELREQK---ELREQ 346
E+ R+E++LR ++ REQ+ E+ R+E++LR +++ REQE+E EQK E REQ
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE-----QEQKMRDQEERMWE 401
+ +++E + W + E+ E+ E+ R+++ +QE++ RE +E++ R+Q+ER +
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 402 Q----------------------DERLREKEERMREQEKMWEQVEKMREEKKMQE----- 434
Q +RLR +++ REQE+ EQ+ K EEK++++
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 435 ---------------------QEKKTRDQEEKMQ-----------EEERIREREKKMREE 462
Q++ R+QEE+++ E+E RE+ K E
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 463 EETMREQEEKMQKQEENMWEQ---EEKEWQQQRLP-EQKEKLWEQEKMQEQEEKIWEQE- 517
EE R+Q K ++QEE +Q E++E ++QRL E++E+ EQ +E EE+ EQE
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685
Query: 518 ---------EKIRDQEEMW---------GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
E+I+ + W ++ K++ + + +E + + EQEEK R +E +
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 560 M-WDQEERMEKKTQEQEKK---TWD-QEEKMREEERMR---------EREKKMREEEEMM 605
+ W +EER ++ QE+E++ TW Q E+ E R R +RE+++R EE
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805
Query: 606 REQ----EEKMQEQEEKMQEQEEK---MWEQEEKMQEQE--EKMWEQEEKMWEQEEKMWE 656
REQ EE+ +EQ + + + EK E+EE++Q +E +++ E+E+ + E +E+
Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 657 QQRLPEQKEKLWEHEK-------------------MQEQEKMQEQEEKIWEQEKMEKKTQ 697
Q++ +QK + W+ E+ +EQ+ +QE+EE++ +E+ +++ Q
Sbjct: 866 QEQRRDQKWR-WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 698 EQEKKTWDQEKMREEESM---REREKKMREEEEMMREQEEKMQEQEEKM--QEQEEEMWE 752
EQE++ ++E++++EE EREK+ R+E E +++K+Q++EE++ +E E+ +
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984
Query: 753 QEEKMWEQEEKMW--EQQRLPEQKEKL----WEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806
+ EK + +EE++ E+Q L E++EK WE + ++ E E+E+ +R++ EK R Q
Sbjct: 985 EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 807 E-EKMRGQEEKMRGQEEKMWGQE---------EKMWGQEEKMWGQEEKMWGQEEKMEEKM 856
E E+ +EE+++ +EE++ G+E E+ + +EE++ +EE++ +EE + +
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL-REEPEKRRR 1103
Query: 857 QGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Q +E + RE+EE + +E+ +RE+ EK R QE
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Score = 317 bits (812), Expect = 3e-86
Identities = 197/743 (26%), Positives = 439/743 (59%), Gaps = 54/743 (7%)
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
LQ+ L + ++ + E+L K + LE R + LK++ E +++L E E
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR---EQRLKREQEERRDQLLKREEE 584
Query: 241 KSEIQLNVKELKRKLERAKFL-LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
+ + +L ++ +R +R K + +++ +E+ ++EE E+ +++ K EE+ R++
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 300 ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK--- 356
++LR ++ + REQ K +E+RL ++ K RE E+E REQ+ E++EQ +E+ +
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLK--REHEEERREQELAEEEQEQARERIKSRIP 702
Query: 357 --MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL---REKEE 411
W+ E + ++ K++ + + Q ++ ++E++ R + E W+++ER +++EE
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 412 RMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK-MQEEERIREREKKMREEEETMREQE 470
+ R+ W+ EK ++ R+Q E+ ++ EER + ++ + EEEE + +
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
++ ++++E + +EE++ Q++ +Q ++ E++ +QE +E+ QE++ RDQ+ W E
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQE--EEDGLQEDQERRRSQEQR-RDQKWRWQLE 879
Query: 531 KKMWRQEKMREQEDQMWEQ---EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
++ R+ + + EQ E+++ +E++ +EER +++ QEQE++ ++E+ +E
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 588 EERM--REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE 645
EE++ EREK+ R+E E +++K+Q++EE++ + E E++ +++ EK + +EE
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE-----EPEKRRRQEREKKYREEE 994
Query: 646 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705
++ ++EE++ ++R ++++ WE + ++++++Q++EE++ +E+ +++ QE+E++ +
Sbjct: 995 ELQQEEEQLLREEREKRRRQE-WERQ-YRKKDELQQEEEQLLREEREKRRLQERERQYRE 1052
Query: 706 QEKMREEESM-----------REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE 754
+E++++EE +E E++ R+EEE+ +E+E+ ++E+ EK + QE E +E
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 755 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK-MRGQEEKMRGQ 813
E+ +QE E+Q L E++EK + QE E+ + +EE+++ +EE+ +R + EK R Q
Sbjct: 1113 EEELQQE----EEQLLREEREK----RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 814 E-EKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG 872
E E+ +EE++ +EE++ +E++ QE + ++ + EE++Q Q+ K R ++E R
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERE---RQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 873 QEEKMREQEEKMRGQEEKIYCVG 895
+ E E++ ++ K+YC G
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKG 1244
Score = 310 bits (794), Expect = 4e-84
Identities = 209/724 (28%), Positives = 429/724 (59%), Gaps = 51/724 (7%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL-NVK 249
R + DR +EE +R + + E + +E QE+L + ++ + +L +
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAEGE---EQSEKQERLEQRDRQRRDEELWRQR 177
Query: 250 ELKRKLERAKFLLPQVQTNTLQE-EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK 308
+ ++ E + Q+Q+ E E + EE+LR +E +++ + +Q++R Q+
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 309 MREQEEKMWRQ-EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
+E+EEK WR+ E LR++E++L+E+E + Q+EL+E+EEQ+++ E + +E + EQ
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQ--RQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 368 EEKMWRQEERL-WEQEKQMREQEQKMRDQEERMWEQDER----LREKEERMREQEKMWEQ 422
+++ R+E++L +QE++ REQ+++ R+Q+ER +Q+ER LR ++E REQ+ EQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ----EEKMQKQEE 478
E+ RE++ +EQE++ R+Q+ ++ E+++R RE+++R E++ REQ E++++++++
Sbjct: 356 EEERREQQLRREQEEERREQQ--LRREQQLR-REQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD----QEEMWGQEKKMW 534
EQ+ + QQ R +++E+ ++ + + +E+++ ++E+ RD +EE E++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
+Q+ R+QE++ E+ K+ ++E++ QE R ++ +EQE++ + ++ EEER+++R
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERRE-QQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
+R E+++ REQEE+ +E+ ++ +EEK EQE + Q + + E+ +++ ++EE+
Sbjct: 532 ---LRSEQQLRREQEER---REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585
Query: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
+Q+ EQ+E+L + K +E E+++++E + +++++++ E+E++ Q+ ++ EE
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERR---EQRLKREEPEEERR---QQLLKSEEQ 639
Query: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQ-----EQEEEMWEQEEKMWEQEEKMWE-QQ 768
R++++R E++ REQ K +E+EE+++ E EEE EQE EQE+ +
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE 828
R+P+ + +L E E Q K++ + K Q + QEEK R +E +++ QEE+ ++
Sbjct: 700 RIPKWQWQL-ESEADARQSKVYSRPRKQEGQRRRQE-QEEKRRRRESELQWQEEERAHRQ 757
Query: 829 EKMWGQEEKMWGQEEKMWGQEEKMEEKMQ--GQEEKMREQEEKMRGQEEKMREQEEKMRG 886
+ QEE+ W EEK E Q +REQ E+ EE+ + ++ +
Sbjct: 758 Q----QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 887 QEEK 890
+EEK
Sbjct: 814 EEEK 817
Score = 310 bits (793), Expect = 5e-84
Identities = 223/779 (28%), Positives = 451/779 (57%), Gaps = 96/779 (12%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
R K+ + E +++D L E + EE +K+ + +E+ E E + + +
Sbjct: 1008 REKRRRQEWERQYRKKDELQQE--EEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEEL--REQEKKIRKQEEKMWRQEERLREQEGK 308
+R+ R + L Q + +EE+ ++EE+L E EK+ R++ E+ R+EE L+++E +
Sbjct: 1066 EERETRRRQELERQYRK---EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 309 M-REQEEKMWRQ--EKRLREQEKELREQEKELRE----------QKELREQEEQMQEQEE 355
+ RE+ EK RQ E++ RE+E+ +E+E+ LRE +++ RE+EE QE+E+
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE-------------- 401
+ E++EK R++ E+ +R+EE L Q+++ R +++ R + WE
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 402 -----------QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
+D +LR+++ + Q + EQ E+ RE+++ + Q++ EE+ E E
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 451 RIRE---REKKMREEEETMREQ-EEKMQKQEENMWEQE------EKEWQQQRLPEQKEKL 500
+E R++K +EE++ +RE+ EEK ++QE + +E E+E Q R E+ K
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 501 WEQE-KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE---KMREQEDQM-WEQEEKMRD 555
E+E + QEQ K E+E+++R QE +E+K ++E + +E+E Q+ +++ K R+
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQE----RERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM--REREKKMREEEEMMREQEEKM- 612
+EQ++ QE + + +EQ+ + ++E K EEE+ +ER +K REEE++++E+EE+
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 613 --QEQEEKMQEQEEKMWEQE--EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
QE++ K E+E+++ QE K +EQE + E E K E+E+++ QQR Q++ L
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR---QRKFLQ 1535
Query: 669 EHEKMQEQE----KMQEQEEKIWEQEKMEKKTQEQE--KKTWDQEKMREEESMR--EREK 720
E ++++ QE + Q+++ K E+E++ ++ +EQ+ ++ D++ EE+ +R E+E+
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 721 KMREEEEMMREQE---EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
K E+E+ +R QE + QE++ K +E E+ + E+EE+ ++E+ ++ E++ +L
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER---DRKFLEEEPQL 1652
Query: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMR-GQEEKMRGQE--EKMRGQEEKMWGQE-EKMWG 833
E+ EQ+ +++ K R++E+ ++ G+E+++R QE K R +E+++ QE E+ +
Sbjct: 1653 RRQER--EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 834 QEEKMWGQE--EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
QEE+ ++ E+ + +EE++ ++ + ++ + +E+ K+ +E+ E+EE+ ++E+
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Score = 305 bits (782), Expect = 1e-82
Identities = 225/783 (28%), Positives = 440/783 (56%), Gaps = 92/783 (11%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
R ++ +R ++L +E++ E EE +++ +++L + + E QL ++
Sbjct: 340 RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL-REQEGKM 309
R+ ++ L + Q ++++ R+++ REQE++ +Q+ + R+E+RL REQE +
Sbjct: 400 QLRREQQ----LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 310 ----REQEEKMWRQEKRL----REQEKELRE-----QEKELREQKELREQEEQMQEQEEK 356
RE+E + QE+R R+QE+E RE +E+E REQ+E REQ Q++ ++E+
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ--QLRREQEE 513
Query: 357 MWEQEEKMREQEEKMW---RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
EQ K +E+EE++ R E++L ++++ REQ K R++E+R+ ++ R K E+
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK-REEEKRLEQERREQRLKREQE 572
Query: 414 REQEKMWEQVEKMREEKKMQEQEKKT-----RDQEEKMQEEERIREREKKMREEEETMRE 468
++++ ++ E+ R+++ +EQE++ R++ E++++EER RE+ K E EE R+
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER-REQRLKREEPEEERRQ 631
Query: 469 QEEKMQKQEENMWEQ---EEKEWQQQRLP-EQKEKLWEQEKMQEQEEKIWEQE------- 517
Q K ++QEE +Q E++E ++QRL E++E+ EQ +E EE+ EQE
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 518 ---EKIRDQEEMW---------GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM-WDQE 564
E+I+ + W ++ K++ + + +E + + EQEEK R +E ++ W +E
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 565 ERMEKKTQEQEKKT-----WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
ER ++ QE+E++ W EEK + +RE+ E EE+ Q ++ +
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
E+EEK + ++ + ++E + +EE+ ++ E+ Q+L E+++ L E ++ + ++
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA---QQLQEEEDGLQEDQERRRSQEQ 868
Query: 680 QEQEEKIWEQEKMEKKTQE--------QEKKTWDQEKMREEES---MREREKKMREEEEM 728
+ ++ W+ E+ K+ + QE+ +Q+ ++EEE EREK+ R+E+E
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 729 M-REQEEKMQEQEEKMQEQEEEMWEQE-EKMWEQEEKMW--EQQRLPEQKEKLWEHE--- 781
RE+E+ QE+E+ ++E+ E+ QE E+ + +++K+ E+Q L E+ EK E
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988
Query: 782 KMQEQEKIWEQEEK-MRDQEEKMRGQE---------EKMRGQEEKMRGQEEKMWGQE-EK 830
K +E+E++ ++EE+ +R++ EK R QE E + +E+ +R + EK QE E+
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
+ +EE++ +EE++ G EE+ + Q E + R++EE + +E+ +RE+ EK R QE +
Sbjct: 1049 QYREEEELQQEEEQLLG-EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 891 IYC 893
C
Sbjct: 1108 RQC 1110
Score = 305 bits (782), Expect = 1e-82
Identities = 216/770 (28%), Positives = 441/770 (57%), Gaps = 91/770 (11%)
Query: 193 KKADRYIEELTKERDAL---SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249
+K R EEL +E + L E R + +KK+ QE+ L E+ + +L +
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 250 ELKRK------LERAKFLLPQVQTNTLQE--EMWRQEEELREQEKKIRKQEEKMWRQEER 301
E + + E + L + +T QE +R+EEEL+++E+++ ++E + R++ER
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
R+ RE+EE +E+ LRE+ ++ R QE E ++ RE+EE QE+E+ + E+
Sbjct: 1107 ERQ----CREEEELQQEEEQLLREEREKRRRQELE----RQYREEEEVQQEEEQLLREEP 1158
Query: 362 EKMREQE-EKMWRQEERLWEQEKQ-MREQEQKMRDQEERMWEQDERLREKEERMREQEK- 418
EK R QE E+ +R+EE L ++E+Q +RE+++K R + ER + ++E L+ ++ + R +++
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 419 -------MWEQVE-----------KMREEKKMQE-QEKKTRDQEEKMQEEERIREREKKM 459
WE + K RE ++ ++ ++ + RD++ + + + E++++
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278
Query: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW------EQEKMQEQEEKI 513
RE+E +Q ++ +EE + +E+KE +++ Q+EK E+ + QE + K
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 514 WEQEEKIRDQEE--MWGQEK-KMWRQEKMREQED--QMWEQEEKMRDQEQKMWDQEERME 568
E+E+ ++++EE + QE+ + +R+E++R QE + E+E+++R QE++ +E +
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 569 KKTQEQEKK-TWDQEEKMREEERM---REREKKMREEEEMMREQEEK---MQEQEEKMQE 621
+ QE+E++ D++ K REEE+ +ER++K REEE+ +R QE + ++E+++ QE
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 622 QEEKMWEQEEKMQEQEEKM---WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE- 677
+ K E+E+ +QE+EE+ E++ K E+E+++ Q+R K +EQE
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER----------DRKFREQEL 1508
Query: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE----SMREREKKMREEEEMMREQE 733
+ QE E K E+E+ + Q Q K +++++R +E ++R++K REEE++ +E+E
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 734 EKMQEQEE-----KMQEQEEEMWEQEEKMWEQEEKMWE---QQRLPEQKEKLWEHEKMQE 785
E+ ++E +++EQ+ EQE K E E+++ QQ+L +++++ + ++
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628
Query: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQ--EEKMRGQEEKMWGQEEKMW--GQEEKMWGQ 841
QE+ EQ+ ++++ K +E ++R Q E+++R ++ + +EE++ G+E+++ Q
Sbjct: 1629 QER-EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE-EKMREQEEKMRGQEEK 890
E +EE+ + + Q +E K ++E+++R QE E+ +EE++R + E+
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Score = 305 bits (782), Expect = 1e-82
Identities = 218/796 (27%), Positives = 456/796 (57%), Gaps = 80/796 (10%)
Query: 162 GESKDLAGR--LHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTIT 219
GE ++ R L + ELQ+ + + R E + R+ L+ +
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 220 NEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 279
EE +K+ +++L E+ E+Q ++L R+ E K +++ +EE +QEE
Sbjct: 1125 REEREKRR---RQELERQYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEE 1180
Query: 280 E--LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-------WRQEKRLREQEKEL 330
E LRE+++K R++ E+ +R+EE L+ Q+ K R ++E W EK ++ ++
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Query: 331 ------REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
EQ ++L E +LR+++ Q Q+ + + EQ+E+ REQE + W+Q +R + +E+Q
Sbjct: 1241 YCKGRENEQFRQL-EDSQLRDRQSQ-QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298
Query: 385 MREQEQKMRDQEERMWEQDERL--REKEERMREQE-----KMWEQVEKMREEKKMQEQEK 437
+ +EQK + +R +++++L E+EE+ R QE + EQ+ + REE+ ++ QE+
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 438 KTRDQEEKM----------QEEERIR--EREKKMREEEETMR--EQEEKMQKQEENMWEQ 483
+ +EE++ +EE+R+R ERE+K +EE+ +R E+E+++++ + + +
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
EE++ +Q + + +Q + QE+E K E+E+++R + +E++ QE+ EQ+
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER-EEQQ 1477
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM---REREKKMRE 600
E++ K ++EQ++ QE ++K +EQE ++ + E K EEE+ ++R++K +
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQER--DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 601 EEEMMREQE---EKMQEQEEKMQEQEEKMWEQEEKM---QEQEEKMWEQEEKMWEQEEK- 653
EE+ +R QE ++ Q+++ K +E+E+ E+EE+ QE++ K +E+K+ QE++
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 654 --MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE---- 707
M ++Q+L Q+ + + + + K +E E+ + E+E+ + QE+++K ++E
Sbjct: 1596 KFMEDEQQLRRQEGQ--QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 708 -KMREEESMREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEEMWEQE-EKMWEQEE 762
+ RE++ +R++K REEE++++E EE + QE++ K +E+E+++ QE E+ + QEE
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 763 KMWEQQRLPE--QKEKLWEHEKMQEQEKIWEQEEKMRDQEE-KMRGQEEKMRGQEEKMRG 819
+ +Q L ++E+ E QEQ + E+ K+ ++E+ + +E+++R QE +
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 820 QEEKMWGQEEKMWGQEEKMWGQE-EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
+EE+ QE +E+++ QE ++ + +EE++ ++ + Q+ + ++++ K R +EE+++
Sbjct: 1774 REEEQLRQER----EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 879 --EQEEKMRGQEEKIY 892
EQE+++R + ++ Y
Sbjct: 1830 LEEQEQRLRQERDRQY 1845
Score = 303 bits (775), Expect = 6e-82
Identities = 222/768 (28%), Positives = 439/768 (57%), Gaps = 89/768 (11%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
ELQ+ + ++ R E + R L+ + EE +K+ + +E+
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC---R 1111
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE--LREQEKKIRKQE-EKMW 296
E+ E+Q ++L R+ ER K +++ +EE +QEEE LRE+ +K R+QE E+ +
Sbjct: 1112 EEEELQQEEEQLLRE-EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 297 RQEERLREQEGKM-REQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R+EE L+++E ++ RE+ QEKR +E+E++ RE+E+ R++++ R ++E + +
Sbjct: 1171 REEEELQQEEEQLLREE------QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 356 KMWEQE-----------------EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
WE E E+ R+ E+ R + + + + EQ+++ R+QE R
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR 1284
Query: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
W+Q +R +EE++ + EQ E R ++K QE+++ R++ E E+ R +E ++K
Sbjct: 1285 RWQQRDRHFPEEEQLERE----EQKEAKRRDRKSQEEKQLLREERE---EKRRRQETDRK 1337
Query: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE---KMQEQEEKIWE 515
REEE+ ++E+EE+ +++E + E+E + Q EQ K E+E + QE+E K +
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRHQ---EQGRKFLEEEQRLRRQERERKFLK 1394
Query: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE--EKMRDQEQKMWDQEERMEKKTQE 573
+E+++R QE Q+ + R K RE+E Q+ QE K R++EQ++ ++ER K +E
Sbjct: 1395 EEQQLRCQER--EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV-RRQERERKFLEE 1451
Query: 574 QEKKTWDQEEKMREEERM-----------REREKKMREEEEMMREQE--EKMQEQEEKMQ 620
+++ ++ K REEE++ +ER++K EEE+ +R QE K +EQE + Q
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 621 EQEEKMWEQEEKM-QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM----QE 675
E E K E+E+++ ++Q ++ + QEE+ ++E+ QQR ++ K E E++ +E
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER--GQQRRQDRDRKFREEEQLRQEREE 1569
Query: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTW-DQEKMREEESM----REREKKMREEEEMMR 730
Q+ +++ ++ + E+ + + QEQE+K D++++R +E +ER++K RE+E++++
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 731 EQEEKM---QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
E+EE+ QE++ K E+E ++ QE EQ+ + ++ E+++ L E E+ Q +
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQER---EQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Query: 788 KIWEQEEKMRDQEEKMRGQ--EEKMRGQEEKMRGQE-EKMWGQEEKMWGQEEKMWGQEEK 844
+ E++ K R++E+++R Q E K +E+++R QE E+ + +EE++ + E+ + ++
Sbjct: 1687 Q--ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 845 MWG---QEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE-KMRGQE 888
+ +EE++ + + Q+ + +E++ K R +E+ +E+EE ++R QE
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Score = 296 bits (759), Expect = 4e-80
Identities = 208/664 (31%), Positives = 394/664 (59%), Gaps = 67/664 (10%)
Query: 276 RQEEELREQEKKIRK-QEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE 334
RQEE+ R E + R+ +EE R+ ++ +EQE ++ E EE+ +QE RL +++++ R++E
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQE-RLEQRDRQRRDEE 172
Query: 335 -----KELREQKELREQEEQMQE---QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
+E +E++E R +EEQ+Q E + + EE++R +E R++ R +Q+++
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE 232
Query: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT--RDQEE 444
Q++ +++EE+ W + E + KEE ++E+ Q E EE+++++ E++ R+++E
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292
Query: 445 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP---------- 494
+ Q+++R+R ++ R++EE REQ+E+ ++Q+E +QEE+ QQ R
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 495 -EQKEKLWEQEKMQEQEEKIWEQ----EEKIRDQEEMWGQEKKMWRQEKMREQE---DQM 546
EQ+E+ EQ+ +EQEE+ EQ E+++R ++++ +++ Q+ REQ+ +Q
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW----DQEEK----MREEERMREREKKM 598
+E+++R ++Q +QEE ++ EQE++ +QEE+ REEE ER ++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE--TERHEQE 470
Query: 599 REEEEMMREQEEKMQEQEEKMQEQE--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
R ++++ R+QEE+ +E+ K++E+E E+ +E++++ ++E+ EQ K E+EE++
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL-- 528
Query: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716
QQRL +++ E E+ +EQ ++ +EEK EQE+ E++ + ++++ DQ REEE +
Sbjct: 529 QQRLRSEQQLRREQEERREQ-LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Query: 717 EREKKMREE--------EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
+R K+ +EE EE+ R ++E+ +EQ K +E EEE +Q K EQEE+ +QQ
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR-QQQ 646
Query: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ---EEKMRGQEEKMRGQEEK-M 824
EQ+E+ + K +E+E+ EQ K R+ EE+ R Q EE+ E+++ + K
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLK-REHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Query: 825 WGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK---MREQE 881
W E + ++ K++ + K GQ + E QEEK R +E +++ QEE+ ++QE
Sbjct: 706 WQLESEADARQSKVYSRPRKQEGQRRRQE-----QEEKRRRRESELQWQEEERAHRQQQE 760
Query: 882 EKMR 885
E+ R
Sbjct: 761 EEQR 764
Score = 288 bits (738), Expect = 1e-77
Identities = 184/619 (29%), Positives = 372/619 (60%), Gaps = 49/619 (7%)
Query: 292 EEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQ 351
EEK R + + + + +E++++ + R E+E R ++K +++EL E EEQ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 352 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ----KMRDQEERMWEQDERLR 407
+QE EQ ++ R EE +WRQ + E+E++ E+EQ K + EE E+ R R
Sbjct: 157 KQERL--EQRDRQRRDEE-LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 408 E--------KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459
E +EE+ +++ + ++V + EEK+ +++E R +EEK+QEEE R+RE +
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE--L 271
Query: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
+EEEE +R K+++QE QEE++ QQ+ EQ+ + ++E+ +EQ+E+ EQ+E+
Sbjct: 272 QEEEEQLR----KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 520 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
QEE +E+++ R+++ R ++ EQEE+ R+Q+ + +EER E++ + +++
Sbjct: 328 REQQEER--REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 580 DQ----EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
+Q E+++R E+++R RE+++R E+++ REQ+ + ++Q + QE+E + E++ +E
Sbjct: 386 EQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 636 QEEKMWEQEEKMW---EQEEKMWEQQR--------LPEQKEKLW---EHEKMQEQEKMQE 681
Q K ++E + W E+E + EQ+R E++ + W E E+ +EQ++ +E
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Q+ + ++E+ E++ + QE++ Q+++R E+ +R +++ R E++++ +EEK EQE
Sbjct: 505 QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR--EQLLKREEEKRLEQER 562
Query: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
+ Q + E E+ +++ ++EE+ +Q+ EQ+E+L + K +E E++ EQEE+ R+Q
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL-EQEER-REQRL 620
Query: 802 KMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEE 861
K EE+ R Q K QEE+ +++++ ++++ Q K +EE++E++++ + E
Sbjct: 621 KREEPEEERRQQLLKSEEQEER---RQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 862 KMREQEEKMRGQEEKMREQ 880
+ R ++E ++E+ RE+
Sbjct: 678 EERREQELAEEEQEQARER 696
Score = 257 bits (656), Expect = 4e-68
Identities = 182/613 (29%), Positives = 366/613 (59%), Gaps = 52/613 (8%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK--LPLAESEKSEIQLNV 248
R +K+ + L +ER+ E R T+ + +++ LQE+ PL E+ +
Sbjct: 1310 RDRKSQEEKQLLREERE----EKRRRQETDRKFREEEQLLQEREEQPLRRQERDR-KFRE 1364
Query: 249 KELKRKLERAKFLLPQVQTNTLQEE--MWRQEEELR--EQEKKIRKQEEKMWRQEERL-- 302
+EL+ + + KFL + + + E ++E++LR E+E+++R+ ++ +R+EE+
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Query: 303 -REQEGKMREQEEKMWRQ--EKRLREQEKELR-EQEKELREQKE-LREQEEQM---QEQE 354
+E++ K RE+E+++ RQ E++ E+E++LR E+ ++ RE+++ L+E+EEQ QE++
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Query: 355 EKMWEQEEKMREQE--EKMWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDE-RLREKE 410
K E+E+++R QE K QE R E E++ E+EQ++ R Q +R + Q+E +LR +E
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 411 ---ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE-RIREREKKMREEEETM 466
+R +++++ + + E++R+E++ Q+ ++ RD++ +++E++ R +E+E+K E+E+ +
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
R QE + Q ++ E++ K + ++L +++E+ +Q QE++ K E+E ++R QE
Sbjct: 1605 RRQEGQQQLRQ----ERDRKFREDEQLLQEREE--QQLHRQERDRKFLEEEPQLRRQER- 1657
Query: 527 WGQEKKMWRQEKMREQEDQMWE-QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKM 585
Q+ + R K RE+E + E +E+++R QE+ +EE + + QE+E+K +E+++
Sbjct: 1658 -EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 586 REEERMREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEE---KMQEQEEK 639
R + E E+K REEE++ +E E+ + QE+ K+ E+E+ E+EE + QE++ K
Sbjct: 1717 RRQ----ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 640 MWEQEEKMWEQEE---KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT 696
E+E+ E+EE + E R ++E+L + + Q+ Q + WE+E+++ +
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 697 QEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK-MQEQEEKMQEQEEEMWEQEE 755
QEQ + + R EE +EK REE+E+ +E+E+K QE+E K++E+ ++EE
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892
Query: 756 KMWEQEEKMWEQQ 768
+ Q ++ Q+
Sbjct: 1893 QRHRQVGEIKSQE 1905
Score = 243 bits (619), Expect = 8e-64
Identities = 154/584 (26%), Positives = 343/584 (58%), Gaps = 50/584 (8%)
Query: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
++EK R + +++ QE++++ +E ++ E+E R+++R EQE+++ E E++
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ-EQERELAEGEEQ 154
Query: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
QE EQ +R R EE R++++ E+ E+ EE+++Q + + E+ +EE+
Sbjct: 155 SEKQERL--EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH---ETEEFPDEEQ 209
Query: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK--MQEQ 509
+R RE + +Q+++ ++Q+ E+EEKE W + + ++++
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE-------------WRKRETVLRKE 256
Query: 510 EEKIWEQE-EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
EEK+ E+E ++ R+ +E Q +K+ RQE RE++++ +Q+ R+Q+ + +EER E
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE 628
++ + +E++ ++++ R E+++R RE++ R E+++ REQEE+ +EQ+ + +++EE+ +
Sbjct: 317 QQEERREQQERREQQEERREQQLR-REQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 629 QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE 688
Q + Q+ + + E+ +E+++ +Q+L +++ E + +EQ+ +EQEE+ E
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 689 QEKMEK------KTQEQEKKTW---DQEKMREEESMREREKKMREEEE-----MMREQEE 734
Q+ ++ K +++E++ W ++E R E+ R+++ K +EEE + E+EE
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 735 KMQEQEEKMQE---QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
+ ++QE + Q+ ++EE EQ K E+EE++ QQRL +++ E E+ +EQ E
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERL--QQRLRSEQQLRREQEERREQLLKRE 553
Query: 792 QEEKMRDQ--EEKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+E+++ + E++++ ++E+ R Q E+ R Q+ QEE++ E+++ +E +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL---EQRLKREEVERL 610
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
QEE+ E++++ +E + +++ ++ +E++ R Q++ R Q+E+
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Score = 222 bits (566), Expect = 1e-57
Identities = 149/506 (29%), Positives = 302/506 (59%), Gaps = 59/506 (11%)
Query: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481
Q + EEK+ + K++ Q+ + +E++R E + EEE R ++ K Q+QE +
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ-KRQEQERELA 149
Query: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
E EE+ +Q+RL EQ Q ++E++W Q ++ +++EE +E+++ + +
Sbjct: 150 EGEEQSEKQERL--------EQRDRQRRDEELWRQRQEWQEREERRAEEEQL---QSCKG 198
Query: 542 QEDQMWEQEEKMR----------DQEQKMWDQEERMEKKTQEQEKKTW--------DQEE 583
E + + EE++R +E+K + ER ++ QE+E+K W +EE
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 584 KMREEERMREREKKMREEEEMMR--EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641
K++EEE R+RE ++EEEE +R E++E +E++E+ Q+Q+ EQ+ + +++EE+
Sbjct: 259 KLQEEEPQRQRE--LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE-KMEKKTQEQE 700
+QEE+ +QE + +++R +Q + E E+ +EQ+ +EQEE+ EQ+ + E++ + +E
Sbjct: 317 QQEERREQQERREQQEERREQQLRR--EQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ---EEKMQEQEEEMWEQEEKM 757
++ ++++R E+ +R RE+++R E+++ REQ+ + ++Q E++++ +++ EQEE+
Sbjct: 375 QQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 758 WEQE-EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK----MRDQEEKMRGQEEKMRG 812
EQ+ E+ +QRL ++E+ + K +E+ + EQE + RDQEE+ R E ++
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR--ERWLKL 491
Query: 813 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEK--- 869
+EE+ R Q+E+ +E+++ ++E+ Q K +EE+++++++ +++ REQEE+
Sbjct: 492 EEEERREQQER---REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 870 -MRGQEEKMREQEEK----MRGQEEK 890
++ +EEK EQE + R QEE+
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEER 574
Score = 113 bits (283), Expect = 7e-25
Identities = 101/393 (25%), Positives = 190/393 (48%), Gaps = 47/393 (11%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKF-EDG 131
Q+ Q ++++ + +E LR+E E Q + R +K LE Q+ RKF ED
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLS-RQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 132 NLGTPSSFNLALSQA----FRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE---LQRA 184
L Q FR L+ + R F E L+R
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDE------QLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEI 244
RH + ++ EE + L E + +E +K E +++L E E+ +
Sbjct: 1656 EREQQLRHDRDRKFREE-----EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE 304
Q + +++LER Q++ T QE++ RQE K + +++ + R+E++LR
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQER----YRKILEEEQLRPEREEQQLRR 1766
Query: 305 QEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM 364
QE + +EE+ RQE+ EQ+ +E +++ RE+++LR++ E E+++
Sbjct: 1767 QERDRKFREEEQLRQERE--EQQLRSQESDRKFREEEQLRQERE------------EQQL 1812
Query: 365 REQEEKMWRQEERLWEQEK-QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
R Q+ R + WE+E+ Q+ EQEQ++R + +R + +E+ +E+ RE++++W++
Sbjct: 1813 RPQQ----RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE- 1867
Query: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIRERE 456
E+K+ QE+E+K R++ + Q++E R R+
Sbjct: 1868 ---EEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Score = 38.9 bits (89), Expect = 0.022
Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 10/109 (9%)
Query: 791 EQEEKMR-DQEEKM---RGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
++E++ R D +E + R QEE R E + R EE+ GQ + QE+ + E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEP-GQRRRQKRQEQ----ERELAE 150
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
G+E+ +++ Q ++ R EE R Q ++ +E+EE+ +E+ C G
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWR-QRQEWQEREERRAEEEQLQSCKG 198
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 270 bits (690), Expect = 4e-72
Identities = 147/231 (63%), Positives = 169/231 (73%), Gaps = 52/231 (22%)
Query: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
MREEERMREREKKMREEEEMMREQEEKMQEQEEKM+EQEEKMWEQEEKMQEQEEKMWEQE
Sbjct: 1 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 60
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
EKMWEQEEKMWEQQRLPEQKEK+WE + E+++E+EE++ +E+K W
Sbjct: 61 EKMWEQEEKMWEQQRLPEQKEKMWEQD-----ERLREKEERM------------REQKMW 103
Query: 705 DQ-EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763
Q EKMRE++ + +E+KM+E+EE M+EQEE M EQEEKMQEQEE+MWEQEEKM EQEEK
Sbjct: 104 QQVEKMREKK--KTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 161
Query: 764 MWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
M R+QEEKM+GQEEKMR E
Sbjct: 162 M--------------------------------REQEEKMQGQEEKMRDVE 180
Score = 254 bits (650), Expect = 2e-67
Identities = 133/189 (70%), Positives = 156/189 (82%), Gaps = 19/189 (10%)
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
+EE+MR EREKKMREEEEMMREQEEKMQEQEEKM+EQEEKMWEQEEKMQEQEEKM
Sbjct: 3 EEERMR------EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKM 56
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ-EKMEKKTQEQ 699
WEQEEKMWEQEEKMWEQQRLPEQKEK+WE ++ +++ + +E+K+W+Q EKM +K
Sbjct: 57 WEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREK---- 112
Query: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759
KKT +EE M+E+E+KM+E+EEMM EQEEKMQEQEEKM EQEE+M EQEEKM E
Sbjct: 113 -KKT-------QEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE 164
Query: 760 QEEKMWEQQ 768
QEEKM Q+
Sbjct: 165 QEEKMQGQE 173
Score = 248 bits (633), Expect = 2e-65
Identities = 134/185 (72%), Positives = 155/185 (83%), Gaps = 11/185 (5%)
Query: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
MREEE MREREKKMREEEEMMREQEEKMQEQEEKM+EQEE+MWEQEEKM EQEEKMWEQ+
Sbjct: 1 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 60
Query: 769 -RLPEQKEKLWEHEKMQEQ-EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWG 826
++ EQ+EK+WE +++ EQ EK+WEQ+E++R++EE+MR E+KM Q EKMR EK
Sbjct: 61 EKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMR--EQKMWQQVEKMR---EKKKT 115
Query: 827 QEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRG 886
QEEKM QEEKM QEE MW QEEKM+E QEEKM EQEEKMR QEEKMREQEEKM+G
Sbjct: 116 QEEKMQEQEEKMQEQEEMMWEQEEKMQE----QEEKMWEQEEKMREQEEKMREQEEKMQG 171
Query: 887 QEEKI 891
QEEK+
Sbjct: 172 QEEKM 176
Score = 244 bits (622), Expect = 3e-64
Identities = 133/227 (58%), Positives = 172/227 (75%), Gaps = 30/227 (13%)
Query: 318 RQEKRLREQEKELREQEKELREQKE-LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376
R+E+R+RE+EK++RE+E+ +REQ+E ++EQEE+M+EQEEKMWEQEEKM+EQEEKMW QEE
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 377 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE 436
++WEQE++M EQ Q++ +Q+E+MWEQDERLREKEERMREQ KMW+QVEKMRE+KK
Sbjct: 62 KMWEQEEKMWEQ-QRLPEQKEKMWEQDERLREKEERMREQ-KMWQQVEKMREKKK----- 114
Query: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
QEEKMQE+ E+KM+E+EE M EQEEKMQ+QEE MWEQEEK +Q
Sbjct: 115 ----TQEEKMQEQ------EEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ------ 158
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
+EKM+EQEEK+ QEEK+RD E G+ + Q+ QE
Sbjct: 159 ------EEKMREQEEKMQGQEEKMRDVEPAGGEAGEGSPQDNPTAQE 199
Score = 238 bits (608), Expect = 1e-62
Identities = 129/194 (66%), Positives = 150/194 (77%), Gaps = 24/194 (12%)
Query: 697 QEQEKKTWDQEKMREEESM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
+E+E+ ++KMREEE M RE+E+KM+E+EE MREQEEKM EQEEKMQEQEE+MWEQEE
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 756 KMWEQEEKMWEQQRLPEQKEKLWEH--------EKMQEQEKIWEQEEKMRDQEEKMRGQE 807
KMWEQEEKMWEQQRLPEQKEK+WE E+M+EQ K+W+Q EKMR EK + QE
Sbjct: 62 KMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQ-KMWQQVEKMR---EKKKTQE 117
Query: 808 EKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867
EKM+ QEEKM+ QEE MW QEEKM QEEKMW Q EEKM+ QEEKMREQE
Sbjct: 118 EKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQ-----------EEKMREQEEKMREQE 166
Query: 868 EKMRGQEEKMREQE 881
EKM+GQEEKMR+ E
Sbjct: 167 EKMQGQEEKMRDVE 180
Score = 236 bits (601), Expect = 9e-62
Identities = 131/211 (62%), Positives = 158/211 (74%), Gaps = 36/211 (17%)
Query: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
M+EEER+REREKKMREEEE MREQEEKMQ+QEE M EQEEK W+Q+ EK
Sbjct: 1 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE------------EK 48
Query: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE-----QKM 560
MQEQEEK+WEQEEK MW QE+KMW Q+++ EQ+++MWEQ+E++R++E QKM
Sbjct: 49 MQEQEEKMWEQEEK------MWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKM 102
Query: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
W Q E+M +K KKT QEEKM+E+ E+KM+E+EEMM EQEEKMQEQEEKM
Sbjct: 103 WQQVEKMREK-----KKT--QEEKMQEQ------EEKMQEQEEMMWEQEEKMQEQEEKMW 149
Query: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
EQEEKM EQEEKM+EQEEKM QEEKM + E
Sbjct: 150 EQEEKMREQEEKMREQEEKMQGQEEKMRDVE 180
Score = 223 bits (567), Expect = 8e-58
Identities = 118/204 (57%), Positives = 159/204 (77%), Gaps = 30/204 (14%)
Query: 426 MREEKKMQEQEKKTRDQEEKMQE-EERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
MREE++M+E+EKK R++EE M+E EE+++E+E+KMRE+EE M EQEEKMQ+QEE MWEQE
Sbjct: 1 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 60
Query: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKMRE-- 541
EK W EQ+EK+WEQ+++ EQ+EK+WEQ+E++R++EE +E+KMW+Q EKMRE
Sbjct: 61 EKMW------EQEEKMWEQQRLPEQKEKMWEQDERLREKEERM-REQKMWQQVEKMREKK 113
Query: 542 --QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
QE++M EQEEKM++QE+ MW+QEE+M QEQE+K W+QEEK MR
Sbjct: 114 KTQEEKMQEQEEKMQEQEEMMWEQEEKM----QEQEEKMWEQEEK-------------MR 156
Query: 600 EEEEMMREQEEKMQEQEEKMQEQE 623
E+EE MREQEEKMQ QEEKM++ E
Sbjct: 157 EQEEKMREQEEKMQGQEEKMRDVE 180
Score = 204 bits (520), Expect = 2e-52
Identities = 100/181 (55%), Positives = 153/181 (84%), Gaps = 8/181 (4%)
Query: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335
R+EE +RE+EKK+R++EE M QEE+++EQE KMREQEEKMW QE++++EQE+++ EQE+
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 336 ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE----QEQK 391
++ EQ+E +++++ EQ+EKMWEQ+E++RE+EE+M +E+++W+Q ++MRE QE+K
Sbjct: 62 KMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERM--REQKMWQQVEKMREKKKTQEEK 119
Query: 392 MRDQEERMWEQDERLREKEERMREQ-EKMWEQVEKMRE-EKKMQEQEKKTRDQEEKMQEE 449
M++QEE+M EQ+E + E+EE+M+EQ EKMWEQ EKMRE E+KM+EQE+K + QEEKM++
Sbjct: 120 MQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRDV 179
Query: 450 E 450
E
Sbjct: 180 E 180
Score = 204 bits (519), Expect = 3e-52
Identities = 110/195 (56%), Positives = 153/195 (78%), Gaps = 23/195 (11%)
Query: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
R+EER+RE+E KMRE+EE M QE++++EQE+++REQE+++ EQ EE+MQEQEEK
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ------EEKMQEQEEK 55
Query: 357 MWEQEEKMREQEEKMWRQE------ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 410
MWEQEEKM EQEEKMW Q+ E++WEQ++++RE+E++MR+Q +MW+Q E++REK+
Sbjct: 56 MWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQ--KMWQQVEKMREKK 113
Query: 411 ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE-EERIREREKKMREEEETMREQ 469
+ ++EKM EQ E+KMQEQE+ +QEEKMQE EE++ E+E+KMRE+EE MREQ
Sbjct: 114 K--TQEEKMQEQ------EEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 165
Query: 470 EEKMQKQEENMWEQE 484
EEKMQ QEE M + E
Sbjct: 166 EEKMQGQEEKMRDVE 180
Score = 200 bits (509), Expect = 4e-51
Identities = 110/194 (56%), Positives = 141/194 (72%), Gaps = 27/194 (13%)
Query: 566 RMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624
R E++ +E+EKK ++EE MRE EE+M+E+E+KMRE+EE M EQEEKMQEQEEKM EQEE
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 625 KMWEQEEKM------QEQEEKMWEQEEKMWEQEE-----KMWEQQRLPEQKEKLWEHEKM 673
KMWEQEEKM EQ+EKMWEQ+E++ E+EE KMW+Q +K+K E +
Sbjct: 62 KMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQ 121
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
+++EKMQEQEE +WEQ E+K QEQE+K W+Q E+KMRE+EE MREQE
Sbjct: 122 EQEEKMQEQEEMMWEQ---EEKMQEQEEKMWEQ------------EEKMREQEEKMREQE 166
Query: 734 EKMQEQEEKMQEQE 747
EKMQ QEEKM++ E
Sbjct: 167 EKMQGQEEKMRDVE 180
Score = 197 bits (502), Expect = 3e-50
Identities = 109/195 (55%), Positives = 152/195 (77%), Gaps = 19/195 (9%)
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE-EKK 431
R+EER+ E+EK+MRE+E+ MR+QEE+M EQ+E++RE+E EKMWEQ EKM+E E+K
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE------EKMWEQEEKMQEQEEK 55
Query: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
M EQE+K +QEEKM E++R+ E+++KM E++E +RE+EE+M +E+ MW+Q EK ++
Sbjct: 56 MWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERM--REQKMWQQVEK--MRE 111
Query: 492 RLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKMREQEDQMWEQ 549
+ Q+EK+ EQ EKMQEQEE +WEQEEK+++QEE KMW Q EKMREQE++M EQ
Sbjct: 112 KKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEE------KMWEQEEKMREQEEKMREQ 165
Query: 550 EEKMRDQEQKMWDQE 564
EEKM+ QE+KM D E
Sbjct: 166 EEKMQGQEEKMRDVE 180
Score = 196 bits (498), Expect = 8e-50
Identities = 117/210 (55%), Positives = 148/210 (70%), Gaps = 42/210 (20%)
Query: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
+EE+M E+E+KM+E+EE M EQEEKM EQEEKM EQ+ EK+WE E EKMQE
Sbjct: 3 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE------EKMWEQE-----EKMQE 51
Query: 682 QEEKIWEQEKMEKKTQEQEKKTWDQ-EKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
QEEK+WE QE+K W+Q EKM E++ + E+++KM E++E +RE+EE+M+EQ+
Sbjct: 52 QEEKMWE----------QEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQK 101
Query: 741 -----EKMQE----QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
EKM+E QEE+M EQEEKM EQEE MWEQ+ EK+ E E EK+WE
Sbjct: 102 MWQQVEKMREKKKTQEEKMQEQEEKMQEQEEMMWEQE------EKMQEQE-----EKMWE 150
Query: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821
QEEKMR+QEEKMR QEEKM+GQEEKMR E
Sbjct: 151 QEEKMREQEEKMREQEEKMQGQEEKMRDVE 180
Score = 181 bits (458), Expect = 4e-45
Identities = 104/206 (50%), Positives = 144/206 (69%), Gaps = 36/206 (17%)
Query: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
++E +R ER K + + +E M QEE+++EQE+K+R+QEEKMW QEE+++EQE
Sbjct: 1 MREEERMREREKKMREE------EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 54
Query: 308 KMREQEEKMWRQEK------RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
KM EQEEKMW QE+ RL EQ++++ EQ++ L RE+EE+M+EQ KMW+Q
Sbjct: 55 KMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERL------REKEERMREQ--KMWQQV 106
Query: 362 EKMRE----QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417
EKMRE QEEKM QEE++ EQE+ M EQE+KM++QEE+MWEQ+E++RE+EE+MREQ
Sbjct: 107 EKMREKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ- 165
Query: 418 KMWEQVEKMREEKKMQEQEKKTRDQE 443
E+KMQ QE+K RD E
Sbjct: 166 -----------EEKMQGQEEKMRDVE 180
Score = 170 bits (431), Expect = 5e-42
Identities = 90/181 (49%), Positives = 131/181 (72%), Gaps = 13/181 (7%)
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
+ E ++ +E K + E + + +E+M QEE++ EQE+K+++QEEKMW QEE
Sbjct: 2 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 61
Query: 301 RLREQEGKM------REQEEKMWRQEKRLREQEKELREQE-----KELREQKELREQEEQ 349
++ EQE KM EQ+EKMW Q++RLRE+E+ +REQ+ +++RE+K + QEE+
Sbjct: 62 KMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKK--KTQEEK 119
Query: 350 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
MQEQEEKM EQEE M EQEEKM QEE++WEQE++MREQE+KMR+QEE+M Q+E++R+
Sbjct: 120 MQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRDV 179
Query: 410 E 410
E
Sbjct: 180 E 180
Score = 160 bits (405), Expect = 5e-39
Identities = 92/161 (57%), Positives = 118/161 (73%), Gaps = 21/161 (13%)
Query: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-KIWEQEEKMR 797
+EE+M+E+E++M E+EE M EQEEKM EQ+ EKM+EQE K+WEQEEKM+
Sbjct: 3 EEERMREREKKMREEEEMMREQEEKMQEQE------------EKMREQEEKMWEQEEKMQ 50
Query: 798 DQEEKMRGQEEKMRGQEEKMRGQE------EKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851
+QEEKM QEEKM QEEKM Q+ EKMW Q+E++ +EE+M +E+KMW Q EK
Sbjct: 51 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERM--REQKMWQQVEK 108
Query: 852 MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
M EK + QEEKM+EQEEKM+ QEE M EQEEKM+ QEEK++
Sbjct: 109 MREKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMW 149
Score = 160 bits (405), Expect = 5e-39
Identities = 84/185 (45%), Positives = 128/185 (69%), Gaps = 28/185 (15%)
Query: 231 QEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRK 290
+E++ E + E + ++E + K++ + + +E+MW QEE+++EQE+K+ +
Sbjct: 4 EERMREREKKMREEEEMMREQEEKMQEQ-----EEKMREQEEKMWEQEEKMQEQEEKMWE 58
Query: 291 QEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQ----------------E 334
QEEKMW QEE++ EQ+ ++ EQ+EKMW Q++RLRE+E+ +REQ E
Sbjct: 59 QEEKMWEQEEKMWEQQ-RLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQE 117
Query: 335 KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 394
+++ +EQEE+MQEQEE MWEQEEKM+EQEEKMW QEE++ EQE++MREQE+KM+
Sbjct: 118 EKM------QEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQG 171
Query: 395 QEERM 399
QEE+M
Sbjct: 172 QEEKM 176
Score = 120 bits (302), Expect = 4e-27
Identities = 71/163 (43%), Positives = 111/163 (68%), Gaps = 12/163 (7%)
Query: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKL-ERAKFLLPQVQTNTLQEEMWRQEE 279
+E ++K E +EK+ E + E + + E + K+ E+ + + Q + +E+MW Q+E
Sbjct: 29 QEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDE 88
Query: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
LRE+E+++R E+KMW+Q E++RE K + QEEKM QE++++EQE+ + EQE
Sbjct: 89 RLREKEERMR--EQKMWQQVEKMRE---KKKTQEEKMQEQEEKMQEQEEMMWEQE----- 138
Query: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
++++EQEE+M EQEEKM EQEEKMREQEEKM QEE++ + E
Sbjct: 139 -EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRDVE 180
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/128 (36%), Positives = 71/128 (55%), Gaps = 7/128 (5%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE E++ E R E++ +++ L+EK +K Q+ K+K + K
Sbjct: 60 EEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEK 119
Query: 260 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQ 319
+ + +E MW QEE+++E QEEKMW QEE++REQE KMREQEEKM Q
Sbjct: 120 MQEQEEKMQEQEEMMWEQEEKMQE-------QEEKMWEQEEKMREQEEKMREQEEKMQGQ 172
Query: 320 EKRLREQE 327
E+++R+ E
Sbjct: 173 EEKMRDVE 180
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 268 bits (684), Expect = 2e-71
Identities = 203/559 (36%), Positives = 297/559 (53%), Gaps = 106/559 (18%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP LPPHP MSEKT+Q KLA AKKK Y Q G+ GA +KKKIN G++P+T
Sbjct: 1 MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGA--NRKKKIN-GSSPDT 57
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TSGG HSP D+ + E A T+ L Q EL AL
Sbjct: 58 ATSGGYHSPGDS-----------------ATGIYGEGRASSTTLEDLESQYQELAVAL-- 98
Query: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
D + S ++ R S E K H H +
Sbjct: 99 ---------DSSSAIISQLTENINSLVRTSK-----------EEK------KHEIHLVQK 132
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
L R+L K ++ E L E A ++ E+L+ + L+++L ES
Sbjct: 133 LGRSL------FKLKNQTAEPLAPEPPAGPSKV-------EQLQDETNHLRKEL---ESV 176
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
++Q V+ + LL + Q L+E QEE LREQE+++R+QEE++ QEE
Sbjct: 177 GRQLQAEVEN-----NQMLSLLNRRQEERLRE----QEERLREQEERLREQEERLCEQEE 227
Query: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE-LREQEEQMQEQEEKMWE 359
RLREQE ++REQEE++ QE+RLRE E+ L EQE+ L EQ+E LREQEE++ EQEE++ E
Sbjct: 228 RLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCE 287
Query: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
QEE++REQEE++ QEERL EQE+++ EQE+++R+QEER+ EQ E++ QE++
Sbjct: 288 QEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQ--------EKLPGQERL 339
Query: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
E+VEK+ E QE + +E+ER+ ERE+ + E EE + ++E++++Q+E
Sbjct: 340 LEEVEKLLE-------------QERRQEEQERLLERERLLEEVEELL--EQERLRQQDER 384
Query: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMWRQEK 538
+W+QE ++ E+L E E+M E E ++EQ + R E E K Q +
Sbjct: 385 LWQQETL--------QELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLE 436
Query: 539 MREQEDQMWEQEEKMRDQE 557
+ +E + E+ R E
Sbjct: 437 QQVKELKKSGGAEEPRGSE 455
Score = 200 bits (508), Expect = 6e-51
Identities = 106/306 (34%), Positives = 202/306 (66%), Gaps = 34/306 (11%)
Query: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
E ++++ ++K+ E++ Q + E + ++ + QEE++ EQEE++R+Q
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNR--------RQEERLREQEERLREQ 211
Query: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
EE ++REQE+++ EQEE++R+QE+++ +QEER+ EQE++ + EE
Sbjct: 212 EE------------RLREQEERLCEQEERLREQEERLREQEERL----CEQEERLREHEE 255
Query: 584 KMRE-EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
++ E EER+ E+E+++RE+EE + EQEE++ EQEE+++EQEE++ EQEE+++EQEE++ E
Sbjct: 256 RLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCE 315
Query: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM---------E 693
QEE++ EQEE++ EQ++LP Q+ L E EK+ EQE+ QE++E++ E+E++ +
Sbjct: 316 QEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQ 375
Query: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQ 753
++ ++Q+++ W QE ++E E +RE E+ + E + EQ + + E++ + + +
Sbjct: 376 ERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQL 435
Query: 754 EEKMWE 759
E+++ E
Sbjct: 436 EQQVKE 441
Score = 196 bits (498), Expect = 8e-50
Identities = 119/342 (34%), Positives = 221/342 (64%), Gaps = 29/342 (8%)
Query: 314 EKMWRQEKRLREQEKELREQEKELREQK--ELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
+K+ R +L+ Q E E K +L+++ ++++ E + Q + E + +
Sbjct: 131 QKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQML 190
Query: 372 W----RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427
RQEERL EQE+++REQE+++R+QEER+ EQ+ERLRE+EER+REQE+
Sbjct: 191 SLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEE--------- 241
Query: 428 EEKKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
++ EQE++ R+ EE++ ++EER+ E+E+++RE+EE + EQEE++ +QEE + EQEE
Sbjct: 242 ---RLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEE- 297
Query: 487 EWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
RL EQ+E+L EQ E++ EQEE++ EQEE++ +QE++ GQE+ + EK+ EQE +
Sbjct: 298 -----RLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERR 352
Query: 546 MWEQEEKMRDQEQKMWDQEERME-KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
E++E++ ++E+ + + EE +E ++ ++Q+++ W Q+E ++E ER+RE E+ + E
Sbjct: 353 Q-EEQERLLERERLLEEVEELLEQERLRQQDERLW-QQETLQELERLRELERMLELGWEA 410
Query: 605 MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
+ EQ + + E++ + + + E++++E ++ +E +
Sbjct: 411 LYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPR 452
Score = 189 bits (481), Expect = 8e-48
Identities = 122/342 (35%), Positives = 215/342 (62%), Gaps = 20/342 (5%)
Query: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK---MREQEDQMWEQEE 551
E+K ++ +K+ K+ Q + E G K Q++ +R++ + + Q +
Sbjct: 122 EKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQ 181
Query: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEEMMREQEE 610
+ Q + R E++ +EQE++ +QEE++RE EER+ E+E+++RE+EE +REQEE
Sbjct: 182 AEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEE 241
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWE 669
++ EQEE+++E EE++ EQEE++ EQEE++ EQEE++ EQEE++ EQ +RL EQ+E+L E
Sbjct: 242 RLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCE 301
Query: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
E E+++EQEE++ EQ E++ +EQE++ +QEK+ +E + E +K+ E+E
Sbjct: 302 QE-----ERLREQEERLCEQ---EERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQ 353
Query: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE--QE 787
EQE + + E++ E+ EE+ EQ E++ +Q+E++W+Q+ L ++ E+L E E+M E E
Sbjct: 354 EEQERLL--ERERLLEEVEELLEQ-ERLRQQDERLWQQETL-QELERLRELERMLELGWE 409
Query: 788 KIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
++EQ + R E++ E K Q E+ + +K G EE
Sbjct: 410 ALYEQRAEPRSGFEEL-NNENKSTLQLEQQVKELKKSGGAEE 450
Score = 187 bits (476), Expect = 3e-47
Identities = 115/341 (33%), Positives = 216/341 (63%), Gaps = 26/341 (7%)
Query: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
+R +E + + + +++ + + K Q E + + E++++ +R+E E+
Sbjct: 116 VRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELES 175
Query: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQE 524
+ Q + + E N Q++RL EQ+E+L EQE +++EQEE++ EQEE++R+QE
Sbjct: 176 VGRQLQA--EVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQE 233
Query: 525 E-MWGQEKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE 582
E + QE+++ Q E++RE E+++ EQEE++ +QE+++ +QEER+ EQE++ +QE
Sbjct: 234 ERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERL----HEQEERLCEQE 289
Query: 583 EKMRE-EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE-----EKMWEQEEKMQEQ 636
E++RE EER+ E+E+++RE+EE + EQEE+++EQEE++ EQE E++ E+ EK+ EQ
Sbjct: 290 ERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQ 349
Query: 637 EEKMWEQE-----EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI---WE 688
E + EQE E++ E+ E++ EQ+RL +Q E+LW+ E +QE E+++E E + WE
Sbjct: 350 ERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWE 409
Query: 689 ---QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
+++ E ++ +E ++ ++ E+ ++E +K EE
Sbjct: 410 ALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEE 450
Score = 181 bits (459), Expect = 3e-45
Identities = 121/333 (36%), Positives = 201/333 (60%), Gaps = 50/333 (15%)
Query: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKM-REEEEMMREQEEKMQEQEEKMQEQE 623
E+++ +T K+ +++ E + + R +EE +REQEE+++EQEE+++EQE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQE 219
Query: 624 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE-QQRLPEQKEKLWEHEKMQEQEKMQEQ 682
E++ EQEE+++EQEE++ EQEE++ EQEE++ E ++RL EQ+E+L E E E+++EQ
Sbjct: 220 ERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQE-----ERLREQ 274
Query: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742
EE++ EQ EE + E+E+++RE+EE + EQEE+++EQEE+
Sbjct: 275 EERLHEQ----------------------EERLCEQEERLREQEERLCEQEERLREQEER 312
Query: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ-EQEKIWEQEEKMRDQEE 801
+ EQEE + EQEE++ EQ EK+ Q+RL E+ EKL E E+ Q EQE++ E+E + + EE
Sbjct: 313 LCEQEERLREQEERLCEQ-EKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEE 371
Query: 802 KMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM----W-GQEEKMEEKM 856
+ ++E++R Q+E++W QE QE + + E+M W E+ E
Sbjct: 372 LL---------EQERLRQQDERLWQQETL---QELERLRELERMLELGWEALYEQRAEPR 419
Query: 857 QGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
G EE E + + Q E+ ++ +K G EE
Sbjct: 420 SGFEELNNENKSTL--QLEQQVKELKKSGGAEE 450
Score = 155 bits (391), Expect = 2e-37
Identities = 90/227 (39%), Positives = 153/227 (67%), Gaps = 22/227 (9%)
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
EQ + E +E ++ ++ E E+ + R +EE +REQEE+++EQEE+++EQE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQE 219
Query: 748 EEMWEQEEKMWEQEEKMWEQQ-RLPEQKEKLWEHEKM--QEQEKIWEQEEKMRDQEEKMR 804
E + EQEE++ EQEE++ EQ+ RL EQ+E+L EHE+ +++E++ EQEE++R+QEE++
Sbjct: 220 ERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLH 279
Query: 805 GQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM--EEKMQGQE-- 860
QEE++ QEE++R QEE++ QEE++ QEE++ QEE++ QEE++ +EK+ GQE
Sbjct: 280 EQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERL 339
Query: 861 ----EKMREQEEKMRGQE-----EKMRE------QEEKMRGQEEKIY 892
EK+ EQE + QE E++ E ++E++R Q+E+++
Sbjct: 340 LEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLW 386
Score = 148 bits (374), Expect = 2e-35
Identities = 105/336 (31%), Positives = 193/336 (57%), Gaps = 30/336 (8%)
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
+T ++EKK E ++ R K + E + + + E++Q++ + ++
Sbjct: 117 RTSKEEKK----HEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKE 172
Query: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
E + Q + E + + + +++RL EQ+E+L E E E+++EQEE++ EQ
Sbjct: 173 LESVGRQLQAEVENNQMLSLLNRR--QEERLREQEERLREQE-----ERLREQEERLCEQ 225
Query: 690 E----KMEKKTQEQEKKTWDQ-EKMRE--------EESMREREKKMREEEEMMREQEEKM 736
E + E++ +EQE++ +Q E++RE EE + E+E+++RE+EE + EQEE++
Sbjct: 226 EERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERL 285
Query: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWEHEKMQEQEKIWEQEEK 795
EQEE+++EQEE + EQEE++ EQEE++ EQ +RL EQ+E+L E EK+ QE++ E+ EK
Sbjct: 286 CEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEK 345
Query: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEK 855
+ +QE R QEE+ R E + +E + ++E++ Q+E++W QE + + E+
Sbjct: 346 LLEQE---RRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELER 402
Query: 856 M--QGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
M G E ++ E G EE E + ++ +++
Sbjct: 403 MLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQ 438
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 256 bits (654), Expect = 7e-68
Identities = 195/654 (29%), Positives = 338/654 (51%), Gaps = 117/654 (17%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP+LPPHPMM E++RQNKLA AKKK +Y+Q G+ GA TKKKK + ++PET
Sbjct: 1 MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAK-TKKKKTD--SSPET 57
Query: 61 TTSGGCHSPEDTQ-------------------QNRAQLKEEKK-ASHQHQEALRREIEAQ 100
TTSGGCHSP D+Q +N LK++KK HQ +EA + E
Sbjct: 58 TTSGGCHSPGDSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIH 117
Query: 101 D------HTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGC 154
TI ILT +K +L+T LY+++ AAR FE+
Sbjct: 118 KAQMERLETINILTLEKADLKTTLYHTKRAARHFEE------------------------ 153
Query: 155 VSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELY 214
ESKDLAGRL +S EL+RAL AVST+ ++ DR + R+A+
Sbjct: 154 --------ESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRS----SSCREAVLQRWL 201
Query: 215 RNTITNEELKKKNA-ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273
+ TI L + ++ E L + E+ E ++K + + + + + V+ TL+EE
Sbjct: 202 QQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKM-SVEARTLKEE 260
Query: 274 MWRQEEELREQEKKIRKQE------------------EKMWRQEERLREQ----EGKMRE 311
R ++E E+ + + + E++ + + LR++ EGK++
Sbjct: 261 KKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQS 320
Query: 312 QEEKMW-------RQEKRLREQEKELREQEKE-LREQKELREQEEQMQEQEEKMWEQEEK 363
Q E Q++RL+EQE+ LREQE + +REQ+ L EQ E+++EQ++ + EQ E+
Sbjct: 321 QVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGER 380
Query: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
+R+QE+++ +QEERL ++E+++++QE+++ DQEER+W+++ERL+++EER+ + ++
Sbjct: 381 LRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQN--HKL 438
Query: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE-ETMREQEEKMQKQ------ 476
+K E + E +++ +Q E++++E ++K+ EE E Q ++++ Q
Sbjct: 439 DKQLAEPQC-SFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASHQNQQLETQLSLVAL 497
Query: 477 -------EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E+EE +PE E + ++ + E++ +E + Q
Sbjct: 498 PGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQ 557
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
+ + MRE ++E + + + + + R+ +K +E + K + +E
Sbjct: 558 PSGV--TDGMRE-SFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQE 608
Score = 128 bits (321), Expect = 3e-29
Identities = 118/536 (22%), Positives = 252/536 (47%), Gaps = 79/536 (14%)
Query: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN--TLQEEMWRQEEEL 281
KKK + + + S +EL LE + + Q+ N +L+++ + E +L
Sbjct: 47 KKKKTDSSPETTTSGGCHSPGDSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQL 106
Query: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ- 340
E +K + + + E + + + + ++ ++ R E+E ++ L+
Sbjct: 107 EEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSL 166
Query: 341 KELREQEEQM-----QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
+ ++E E + Q+QEE ++ RE + W Q+ + E+ Q
Sbjct: 167 QRIQELERALCAVSTQQQEE---DRSSSCREAVLQRWLQQT-IKERALLNAHVTQVTESL 222
Query: 396 EERMWEQDERLRE-KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454
++ E+DE + K ER R QE+MW+ + R K EEK ++ RI+E
Sbjct: 223 KQVQLERDEYAKHIKGERARWQERMWKMSVEARTLK------------EEKKRDIHRIQE 270
Query: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 514
E+ + E + M E ++ EQ + E + R ++++ E K+
Sbjct: 271 LERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLR-----------QEVEGLEGKLQ 319
Query: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574
Q E + + +EQ+ ++ EQEE +R+QE
Sbjct: 320 SQVENNQALSLL------------SKEQKQRLQEQEEMLREQEA---------------- 351
Query: 575 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ 634
+++RE+ER+ E+ +++RE+++ ++EQ E++++QE+++++QEE++ ++EE++Q
Sbjct: 352 --------QRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQ 403
Query: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ-EKMQEQEEKIWEQEKME 693
+QE+++W+QEE++W++EE++ +Q E++ L ++ K+ +Q + Q E + ++K
Sbjct: 404 KQEKRLWDQEERLWKKEERLQKQ----EERLALSQNHKLDKQLAEPQCSFEDLNNEKKSA 459
Query: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749
+ ++Q K+ QEK+ EE + + E ++ + + + +EEE
Sbjct: 460 LQLEQQVKEL--QEKLDEEHLEAASHQNQQLETQLSLVALPGEGDGGQHLDSEEEE 513
Score = 120 bits (300), Expect = 7e-27
Identities = 87/350 (24%), Positives = 183/350 (52%), Gaps = 37/350 (10%)
Query: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE--------KMREEERMREREK 596
Q+ E E ++ Q++++ Q E +K E K ++ E K + + ++
Sbjct: 87 QLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKR 146
Query: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM--WEQE--- 651
R EE ++ ++Q +++QE E + + QE++ +E + W Q+
Sbjct: 147 AARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLQRWLQQTIK 206
Query: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711
E+ + + E L + + +++ + E+ QE+M K + E +T +EK R+
Sbjct: 207 ERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEA--RTLKEEKKRD 264
Query: 712 EESMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
++E E+ + E + M E E++Q++ + ++++ E + + + E
Sbjct: 265 IHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVEN 324
Query: 761 EEKMW-----EQQRLPEQKEKLWEHE--KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813
+ + ++QRL EQ+E L E E +++EQE++ EQ E++R+Q++ ++ Q E++R Q
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
E+++R QEE++ +EE++ QE+++W QEE++W K EE++Q QEE++
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLW----KKEERLQKQEERL 430
Score = 117 bits (293), Expect = 5e-26
Identities = 110/423 (26%), Positives = 205/423 (48%), Gaps = 32/423 (7%)
Query: 376 ERLWEQEKQMREQ-EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
E L +Q+KQ+ Q E+ + E Q ERL E+ + + + + E
Sbjct: 93 ESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFE 152
Query: 435 QEKKTRDQEEKMQEE-ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
+E K D ++Q +RI+E E+ + +E++ +E + + W QQ +
Sbjct: 153 EESK--DLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVL-----QRWLQQTI 205
Query: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553
E+ L Q E Q E+ + + G E+ W++ + + +EEK
Sbjct: 206 KERA--LLNAHVTQVTESLKQVQLERDEYAKHIKG-ERARWQERMWKMSVEARTLKEEKK 262
Query: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613
RD + + E K Q E + E++++ K +R+E E + E K+Q
Sbjct: 263 RDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGL---EGKLQ 319
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK- 672
Q E Q EQ++++QEQEE + EQE +++ EQ+RL EQ E+L E +K
Sbjct: 320 SQVENNQALSLLSKEQKQRLQEQEEMLREQEA------QRVREQERLCEQNERLREQQKT 373
Query: 673 MQEQ-EKMQEQEEKIWEQE----KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
+QEQ E++++QE+++ +QE K E++ Q+QEK+ WDQ EE ++ E+ ++EE
Sbjct: 374 LQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ----EERLWKKEERLQKQEER 429
Query: 728 MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE-QQRLPEQKEKLWEHEKMQEQ 786
+ Q K+ +Q + Q E++ +++ + E+++ E Q++L E+ + H+ Q +
Sbjct: 430 LALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASHQNQQLE 489
Query: 787 EKI 789
++
Sbjct: 490 TQL 492
Score = 90.9 bits (224), Expect = 5e-18
Identities = 77/343 (22%), Positives = 174/343 (50%), Gaps = 30/343 (8%)
Query: 550 EEKMRDQEQKMWDQEERMEK--------KTQEQEKKTWDQEEKMREEERMREREKKMREE 601
EE+ +D ++ +R+++ TQ+QE+ D+ RE R ++ ++E
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALCAVSTQQQEE---DRSSSCREAVLQRWLQQTIKER 208
Query: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE-EKMWEQEEKMWEQQRL 660
+ + + ++ E++E + + +E+MW+ E +EEK + R+
Sbjct: 209 ALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRI 268
Query: 661 PEQKEKLWE-HEKMQEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
E + L E +M E + + EQ + E K QE + + + + E+ +
Sbjct: 269 QELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQAL 328
Query: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQKEKL 777
+E+++ ++EQEE ++EQE + ++E + EQ E++ EQ++ + EQ +RL +Q+++L
Sbjct: 329 SLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRL 388
Query: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK 837
+ QE+ ++EE+++ QE+++ QEE++ +EE+++ QEE++ Q K
Sbjct: 389 ----RKQEERLR-KEEERLQKQEKRLWDQEERLWKKEERLQKQEERL------ALSQNHK 437
Query: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
+ +K + + E + +++ + E++++ +EK+ E+
Sbjct: 438 L----DKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEE 476
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 254 bits (649), Expect = 3e-67
Identities = 200/652 (30%), Positives = 340/652 (52%), Gaps = 113/652 (17%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP+LPPHPMM E++RQNKLA AKKK +Y+Q G+ GA TKKKK + ++PET
Sbjct: 1 MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAK-TKKKKTD--SSPET 57
Query: 61 TTSGGCHSPEDTQ-------------------QNRAQLKEEKK-ASHQHQEALRREIEA- 99
TTSGG HSP D+Q +N LK++KK HQ +EA + E
Sbjct: 58 TTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIH 117
Query: 100 -----QDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGC 154
Q TI ILT +K +L+T LY+++ AAR FE+
Sbjct: 118 KAQMEQLETINILTLEKADLKTTLYHTKRAARHFEE------------------------ 153
Query: 155 VSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELY 214
ESKDLAGRL +S EL+RALSAVST+ ++ DR + R+A+
Sbjct: 154 --------ESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRS----SSCREAVLQRRL 201
Query: 215 RNTITNEELKKKNA-ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273
+ TI L + ++ E L + E+ E ++K + + + + + V+ TL+EE
Sbjct: 202 QQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKM-SVEARTLKEE 260
Query: 274 MWRQEEELREQEKKIRKQE------------------EKMWRQEERLREQ----EGKMRE 311
R ++E E+ + + + E++ + + LR++ EGK++
Sbjct: 261 KKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQS 320
Query: 312 QEEKMW-------RQEKRLREQEKELREQEKE-LREQKELREQEEQMQEQEEKMWEQEEK 363
Q E Q++RL+EQE+ LREQE + +REQ+ L EQ E+++EQ++ + EQ E+
Sbjct: 321 QVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGER 380
Query: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER--MREQEKMWE 421
+R+QE+++ +QEERL ++E+++++QE+++ DQEER+W+++ERL+++EER + + K+ +
Sbjct: 381 LRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDK 440
Query: 422 QV-------EKMREEKKMQEQ-EKKTRDQEEKMQEE--ERIREREKKMREEEETMREQEE 471
Q+ E + EKK Q E++ ++ +EK+ EE E +R +++ + + E
Sbjct: 441 QLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGE 500
Query: 472 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 531
Q + E+EE +PE E + ++ + E++ +E + Q
Sbjct: 501 GDGGQHLDS-EEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPS 559
Query: 532 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
+ + MRE ++E + + + + + R+ +K +E + K + +E
Sbjct: 560 GV--TDGMRE-SFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQE 608
Score = 130 bits (327), Expect = 5e-30
Identities = 114/532 (21%), Positives = 257/532 (48%), Gaps = 73/532 (13%)
Query: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN--TLQEEMWRQEEEL 281
KKK + + + S +EL LE + + Q+ N +L+++ + E +L
Sbjct: 47 KKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQL 106
Query: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ- 340
E +K + + Q E + + + + ++ ++ R E+E ++ L+
Sbjct: 107 EEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSL 166
Query: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
+ ++E E + + E++ +E + R+ ++ ++ + ++ + +++
Sbjct: 167 QRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQ 226
Query: 401 -EQDERLRE-KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
E+DE + K ER R QE+MW+ + R K EEK ++ RI+E E+
Sbjct: 227 LERDEYAKHIKGERARWQERMWKMSVEARTLK------------EEKKRDIHRIQELERS 274
Query: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
+ E + M E ++ EQ + E + R ++++ E K+ Q E
Sbjct: 275 LSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLR-----------QEVEGLEGKLQSQVE 323
Query: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
+ + +EQ+ ++ EQEE +R+QE
Sbjct: 324 NNQALSLL------------SKEQKQRLQEQEEMLREQEA-------------------- 351
Query: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
+++RE+ER+ E+ +++RE+++ ++EQ E++++QE+++++QEE++ ++EE++Q+QE+
Sbjct: 352 ----QRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEK 407
Query: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ-EKMQEQEEKIWEQEKMEKKTQ 697
++W+QEE++W++EE++ +Q E++ L ++ K+ +Q + Q E + ++K + +
Sbjct: 408 RLWDQEERLWKKEERLQKQ----EERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLE 463
Query: 698 EQEKKTWDQEKMREE--ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
+Q K+ QEK+ EE E+ +R +++ + ++ E Q +E+E
Sbjct: 464 QQVKEL--QEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEE 513
Score = 120 bits (301), Expect = 6e-27
Identities = 86/351 (24%), Positives = 185/351 (52%), Gaps = 37/351 (10%)
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE--------KMREEERMRERE 595
+Q+ E E ++ Q++++ Q E +K E K +Q E K + + +
Sbjct: 86 NQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTK 145
Query: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
+ R EE ++ ++Q +++QE E + + QE++ +E + + ++
Sbjct: 146 RAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTI 205
Query: 656 EQQRL-----PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+++ L + E L + + +++ + E+ QE+M K + E +T +EK R
Sbjct: 206 KERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEA--RTLKEEKKR 263
Query: 711 EEESMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEEEMWEQEEKMWE 759
+ ++E E+ + E + M E E++Q++ + ++++ E + + + E
Sbjct: 264 DIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVE 323
Query: 760 QEEKMW-----EQQRLPEQKEKLWEHE--KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812
+ + ++QRL EQ+E L E E +++EQE++ EQ E++R+Q++ ++ Q E++R
Sbjct: 324 NNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRK 383
Query: 813 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
QE+++R QEE++ +EE++ QE+++W QEE++W K EE++Q QEE++
Sbjct: 384 QEQRLRKQEERLRKEEERLQKQEKRLWDQEERLW----KKEERLQKQEERL 430
Score = 117 bits (293), Expect = 5e-26
Identities = 88/447 (19%), Positives = 217/447 (48%), Gaps = 49/447 (10%)
Query: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
+L E + L++Q+K++ Q L E ++ E + EQ E + + + L+
Sbjct: 87 QLNENIESLKQQKKQVEHQ--LEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHT 144
Query: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD 441
++ R E++ +D R+ +R++E E + ++ ++ ++ Q + +
Sbjct: 145 KRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQT 204
Query: 442 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 501
+E+ + + + +++ + R++ K K E W++ + + ++EK
Sbjct: 205 IKERALLNAHVTQVTESLKQVQ-LERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKR 263
Query: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
+ ++QE E + E + ++ + + + E+++D+ + +
Sbjct: 264 DIHRIQELERSLSELKNQMAEPPSL---------------APPAVTSVVEQLQDEAKHLR 308
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
+ E +E K Q Q E +E++++++E+EEM+REQE + ++E++ E
Sbjct: 309 QEVEGLEGKLQSQV------ENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCE 362
Query: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Q E++ EQ++ +QEQ E++ +QE+++ +QEE++ +E+E++Q+
Sbjct: 363 QNERLREQQKTLQEQGERLRKQEQRLRKQEERL------------------RKEEERLQK 404
Query: 682 QEEKIWEQE----KMEKKTQEQEKKTWDQEKMREEESMRERE---KKMREEEEMMREQEE 734
QE+++W+QE K E++ Q+QE++ + + ++ + E + + + E++ + E+
Sbjct: 405 QEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQ 464
Query: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQE 761
+++E +EK+ E+ E Q + E +
Sbjct: 465 QVKELQEKLDEEHLEAASQRNQQLETQ 491
Score = 105 bits (261), Expect = 2e-22
Identities = 96/421 (22%), Positives = 208/421 (49%), Gaps = 56/421 (13%)
Query: 421 EQVEKMREEKKMQEQE----KKTRDQEEKMQEE--ERIREREKKMREEEETMREQEEKMQ 474
E +E ++++KK E + KKT ++ K Q E E I + + + T+ + +
Sbjct: 90 ENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAAR 149
Query: 475 KQEENMWEQEEK-EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
EE + + ++ QR+ E + L Q++E++ E + + +++
Sbjct: 150 HFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERA 209
Query: 534 WRQEKMREQEDQMWEQEEKMRDQ-------EQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
+ + + + +Q + RD+ E+ W +ERM K + E +EEK R
Sbjct: 210 LLNAHVTQVTESL-KQVQLERDEYAKHIKGERARW--QERMWKMSVEARTL---KEEKKR 263
Query: 587 EEERMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEE----KMWEQEE 631
+ R++E E+ + E + M E E++Q++ + ++++ E K+ Q E
Sbjct: 264 DIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVE 323
Query: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Q EQ++++ EQEE + EQ E ++++EQE++ EQ E++ EQ+K
Sbjct: 324 NNQALSLLSKEQKQRLQEQEEMLREQ-----------EAQRVREQERLCEQNERLREQQK 372
Query: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW 751
++ E+ +K +Q ++EE +R+ E++++++E+ + +QEE++ ++EE++Q+QEE +
Sbjct: 373 TLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERL- 430
Query: 752 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK---MQEQEKIWEQEEKMRDQEEKMRGQEE 808
Q K+ +Q P+ + +EK +Q ++++ E +EK+ ++ + Q
Sbjct: 431 -----ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRN 485
Query: 809 K 809
+
Sbjct: 486 Q 486
Score = 95.1 bits (235), Expect = 3e-19
Identities = 102/495 (20%), Positives = 231/495 (46%), Gaps = 30/495 (6%)
Query: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
+E + K +++ K ++Q + + ++KKT E + + +E
Sbjct: 15 EESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQEL 74
Query: 463 EETMREQEEKMQKQEENMWE-QEEKEWQQQRLPEQKEKLWEQEKMQ-EQEEKIWEQEEKI 520
+ + + EN+ +++K+ + +L E K+ E K Q EQ E I I
Sbjct: 75 AVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETI-----NI 129
Query: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK-KTQEQEKKTW 579
E+ + + R E++ + +++ Q++ + E + TQ+QE+
Sbjct: 130 LTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEE--- 186
Query: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
D+ RE R ++ ++E + + + ++ E++E + + +E+
Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQER 246
Query: 640 MWEQE-EKMWEQEEKMWEQQRLPEQKEKLWE-HEKMQEQEKMQEQE-EKIWEQEKMEKKT 696
MW+ E +EEK + R+ E + L E +M E + + EQ + E K
Sbjct: 247 MWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKH 306
Query: 697 QEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
QE + + + + E+ + +E+++ ++EQEE ++EQE + ++E + EQ E+
Sbjct: 307 LRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNER 366
Query: 757 MWEQEEKMWEQ-QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
+ EQ++ + EQ +RL +Q+++L + QE+ ++EE+++ QE+++ QEE++ +EE
Sbjct: 367 LREQQKTLQEQGERLRKQEQRL----RKQEERLR-KEEERLQKQEKRLWDQEERLWKKEE 421
Query: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE 875
+++ QEE++ Q K+ +K + + E + +++ + E++++ +E
Sbjct: 422 RLQKQEERL------ALSQNHKL----DKQLAEPQCSFEDLNNEKKSALQLEQQVKELQE 471
Query: 876 KMREQEEKMRGQEEK 890
K+ E+ + Q +
Sbjct: 472 KLDEEHLEAASQRNQ 486
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 253 bits (646), Expect = 6e-67
Identities = 199/652 (30%), Positives = 339/652 (51%), Gaps = 113/652 (17%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP+LPPHPMM E++RQNKLA AKKK +Y+Q G+ GA TKKKK + ++PET
Sbjct: 1 MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAK-TKKKKTD--SSPET 57
Query: 61 TTSGGCHSPEDTQ-------------------QNRAQLKEEKK-ASHQHQEALRREIEA- 99
TTSGG HSP D+Q +N LK++KK HQ +EA + E
Sbjct: 58 TTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIH 117
Query: 100 -----QDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGC 154
Q TI ILT +K +L+T LY+++ AAR FE+
Sbjct: 118 KAQMEQLETINILTLEKADLKTTLYHTKRAARHFEE------------------------ 153
Query: 155 VSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELY 214
ESKDLAGRL +S EL+RAL AVST+ ++ DR + R+A+
Sbjct: 154 --------ESKDLAGRLQYSLQHIQELERALCAVSTQQQEEDRS----SSCREAVLQRRL 201
Query: 215 RNTITNEELKKKNA-ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273
+ TI L + ++ E L + E+ E ++K + + + + + V+ TL+EE
Sbjct: 202 QQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKM-SVEARTLKEE 260
Query: 274 MWRQEEELREQEKKIRKQE------------------EKMWRQEERLREQ----EGKMRE 311
R ++E E+ + + + E++ + + LR++ EGK++
Sbjct: 261 KKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQS 320
Query: 312 QEEKMW-------RQEKRLREQEKELREQEKE-LREQKELREQEEQMQEQEEKMWEQEEK 363
Q E Q++RL+EQE+ LREQE + +REQ+ L EQ E+++EQ++ + EQ E+
Sbjct: 321 QVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGER 380
Query: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER--MREQEKMWE 421
+R+QE+++ +QEERL ++E+++++QE+++ DQEER+W+++ERL+++EER + + K+ +
Sbjct: 381 LRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDK 440
Query: 422 QV-------EKMREEKKMQEQ-EKKTRDQEEKMQEE--ERIREREKKMREEEETMREQEE 471
Q+ E + EKK Q E++ ++ +EK+ EE E +R +++ + + E
Sbjct: 441 QLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGE 500
Query: 472 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 531
Q + E+EE +PE E + ++ + E++ +E + Q
Sbjct: 501 GDGGQHLDS-EEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPS 559
Query: 532 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
+ + MRE ++E + + + + + R+ +K +E + K + +E
Sbjct: 560 GV--TDGMRE-SFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQE 608
Score = 129 bits (324), Expect = 1e-29
Identities = 114/532 (21%), Positives = 257/532 (48%), Gaps = 73/532 (13%)
Query: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN--TLQEEMWRQEEEL 281
KKK + + + S +EL LE + + Q+ N +L+++ + E +L
Sbjct: 47 KKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQL 106
Query: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ- 340
E +K + + Q E + + + + ++ ++ R E+E ++ L+
Sbjct: 107 EEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSL 166
Query: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
+ ++E E + + E++ +E + R+ ++ ++ + ++ + +++
Sbjct: 167 QHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQ 226
Query: 401 -EQDERLRE-KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
E+DE + K ER R QE+MW+ + R K EEK ++ RI+E E+
Sbjct: 227 LERDEYAKHIKGERARWQERMWKMSVEARTLK------------EEKKRDIHRIQELERS 274
Query: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
+ E + M E ++ EQ + E + R ++++ E K+ Q E
Sbjct: 275 LSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLR-----------QEVEGLEGKLQSQVE 323
Query: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
+ + +EQ+ ++ EQEE +R+QE
Sbjct: 324 NNQALSLL------------SKEQKQRLQEQEEMLREQEA-------------------- 351
Query: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
+++RE+ER+ E+ +++RE+++ ++EQ E++++QE+++++QEE++ ++EE++Q+QE+
Sbjct: 352 ----QRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEK 407
Query: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ-EKMQEQEEKIWEQEKMEKKTQ 697
++W+QEE++W++EE++ +Q E++ L ++ K+ +Q + Q E + ++K + +
Sbjct: 408 RLWDQEERLWKKEERLQKQ----EERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLE 463
Query: 698 EQEKKTWDQEKMREE--ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
+Q K+ QEK+ EE E+ +R +++ + ++ E Q +E+E
Sbjct: 464 QQVKEL--QEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEE 513
Score = 119 bits (299), Expect = 1e-26
Identities = 86/351 (24%), Positives = 184/351 (52%), Gaps = 37/351 (10%)
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE--------KMREEERMRERE 595
+Q+ E E ++ Q++++ Q E +K E K +Q E K + + +
Sbjct: 86 NQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTK 145
Query: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
+ R EE ++ ++Q + +QE E + + QE++ +E + + ++
Sbjct: 146 RAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQTI 205
Query: 656 EQQRL-----PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+++ L + E L + + +++ + E+ QE+M K + E +T +EK R
Sbjct: 206 KERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEA--RTLKEEKKR 263
Query: 711 EEESMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEEEMWEQEEKMWE 759
+ ++E E+ + E + M E E++Q++ + ++++ E + + + E
Sbjct: 264 DIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVE 323
Query: 760 QEEKMW-----EQQRLPEQKEKLWEHE--KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812
+ + ++QRL EQ+E L E E +++EQE++ EQ E++R+Q++ ++ Q E++R
Sbjct: 324 NNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRK 383
Query: 813 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
QE+++R QEE++ +EE++ QE+++W QEE++W K EE++Q QEE++
Sbjct: 384 QEQRLRKQEERLRKEEERLQKQEKRLWDQEERLW----KKEERLQKQEERL 430
Score = 112 bits (280), Expect = 2e-24
Identities = 105/407 (25%), Positives = 198/407 (48%), Gaps = 55/407 (13%)
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE----------EKMQEEERIRE 454
+L E E +++Q+K QVE EE K E E EK + +
Sbjct: 87 QLNENIESLKQQKK---QVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYH 143
Query: 455 REKKMREEEETMREQEEKMQKQEENMWEQEE-------KEWQQQRLPEQKEKLWEQEKMQ 507
++ R EE ++ ++Q +++ E E ++ ++ R +E + ++ Q
Sbjct: 144 TKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQ 203
Query: 508 EQEEK------IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE--------QEEKM 553
+E+ + + E ++ + + K + E+ R QE +MW+ +EEK
Sbjct: 204 TIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE-RMWKMSVEARTLKEEKK 262
Query: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613
RD + + E K Q E + E++++ K +R+E E + E K+Q
Sbjct: 263 RDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGL---EGKLQ 319
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK- 672
Q E Q EQ++++QEQEE + EQE +++ EQ+RL EQ E+L E +K
Sbjct: 320 SQVENNQALSLLSKEQKQRLQEQEEMLREQEA------QRVREQERLCEQNERLREQQKT 373
Query: 673 MQEQ-EKMQEQEEKIWEQE----KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
+QEQ E++++QE+++ +QE K E++ Q+QEK+ WDQ EE ++ E+ ++EE
Sbjct: 374 LQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ----EERLWKKEERLQKQEER 429
Query: 728 MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE-QQRLPEQ 773
+ Q K+ +Q + Q E++ +++ + E+++ E Q++L E+
Sbjct: 430 LALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEE 476
Score = 93.2 bits (230), Expect = 1e-18
Identities = 102/495 (20%), Positives = 230/495 (46%), Gaps = 30/495 (6%)
Query: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
+E + K +++ K ++Q + + ++KKT E + + +E
Sbjct: 15 EESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQEL 74
Query: 463 EETMREQEEKMQKQEENMWE-QEEKEWQQQRLPEQKEKLWEQEKMQ-EQEEKIWEQEEKI 520
+ + + EN+ +++K+ + +L E K+ E K Q EQ E I I
Sbjct: 75 AVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETI-----NI 129
Query: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM-EKKTQEQEKKTW 579
E+ + + R E++ + +++ Q + + E + TQ+QE+
Sbjct: 130 LTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQEE--- 186
Query: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
D+ RE R ++ ++E + + + ++ E++E + + +E+
Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQER 246
Query: 640 MWEQE-EKMWEQEEKMWEQQRLPEQKEKLWE-HEKMQEQEKMQEQE-EKIWEQEKMEKKT 696
MW+ E +EEK + R+ E + L E +M E + + EQ + E K
Sbjct: 247 MWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKH 306
Query: 697 QEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
QE + + + + E+ + +E+++ ++EQEE ++EQE + ++E + EQ E+
Sbjct: 307 LRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNER 366
Query: 757 MWEQEEKMWEQ-QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
+ EQ++ + EQ +RL +Q+++L + QE+ ++EE+++ QE+++ QEE++ +EE
Sbjct: 367 LREQQKTLQEQGERLRKQEQRL----RKQEERLR-KEEERLQKQEKRLWDQEERLWKKEE 421
Query: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE 875
+++ QEE++ Q K+ +K + + E + +++ + E++++ +E
Sbjct: 422 RLQKQEERL------ALSQNHKL----DKQLAEPQCSFEDLNNEKKSALQLEQQVKELQE 471
Query: 876 KMREQEEKMRGQEEK 890
K+ E+ + Q +
Sbjct: 472 KLDEEHLEAASQRNQ 486
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 251 bits (642), Expect = 2e-66
Identities = 191/651 (29%), Positives = 335/651 (51%), Gaps = 111/651 (17%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP+LPPHPMM E++RQNKLA AKKK +Y+Q G+ GA TKKKK + ++PET
Sbjct: 1 MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAK-TKKKKTD--SSPET 57
Query: 61 TTSGGCHSPEDTQ-------------------QNRAQLKEEKK-ASHQHQEALRREIEAQ 100
TTSGG HSP D+Q +N LK++KK HQ +EA + E
Sbjct: 58 TTSGGGHSPGDSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIH 117
Query: 101 D------HTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGC 154
TI ILT +K +L+T LY+++ AAR FE+
Sbjct: 118 KAQMERLETINILTLEKADLKTTLYHTKRAARHFEE------------------------ 153
Query: 155 VSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELY 214
ESKDLAGRL +S EL+RAL AVST+ ++ DR + R+A+
Sbjct: 154 --------ESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRS----SSCREAVLHRRL 201
Query: 215 RNTITNEELKKKNA-ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273
+ TI L + ++ E L + E+ E ++K + + + + + V+ TL+EE
Sbjct: 202 QQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKM-SVEARTLKEE 260
Query: 274 MWRQEEELREQEKKIRKQEEKMWR------------------QEERLREQ----EGKMRE 311
R ++E E+ + + + +M + + + LR++ EGK++
Sbjct: 261 KKRDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQS 320
Query: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQE-EQMQEQEEKMWEQEEKMREQEEK 370
Q E +EQ++ L+EQE+ LREQ+ R +E E++ EQ E++ EQ++ ++EQ E+
Sbjct: 321 QVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGER 380
Query: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK 430
+ +QE+RL +QE+++R++E++++ QE+R+W+Q+ERL +KEER+++QE+ + + +K
Sbjct: 381 LRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDK 440
Query: 431 KMQEQ----EKKTRDQEEKMQEEERIREREKKMREEE-ETMREQEEKMQKQ--------- 476
++ E E +++ +Q E++++E ++K+ EE E +Q ++++ Q
Sbjct: 441 QLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQQNQQLETQLSLVALPGE 500
Query: 477 ----EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 532
+ E+EE +PE E + ++ + E++ +E + Q
Sbjct: 501 GDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSG 560
Query: 533 MWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
+ + MRE ++E + + + + + R+ +K +E + K + +E
Sbjct: 561 V--TDGMRE-SFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQE 608
Score = 125 bits (315), Expect = 1e-28
Identities = 99/442 (22%), Positives = 229/442 (51%), Gaps = 29/442 (6%)
Query: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
+L E + L++Q+K++ Q L E ++ E + E+ E + + + L+
Sbjct: 87 QLNENIESLKQQKKQVEHQ--LEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHT 144
Query: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERM---REQEKMWEQVEKMREEKKMQEQEKK 438
++ R E++ +D R+ +R++E E + Q++ ++ RE + ++
Sbjct: 145 KRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQT 204
Query: 439 TRDQEEKMQEEERIREREKKMR-EEEETMREQEEKMQKQEENMWE--------QEEKEWQ 489
+++ ++ E K+++ E +E + + + + +E MW+ +EEK+
Sbjct: 205 IKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRD 264
Query: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
R+ E + L E + + + + E E K RQE + E ++ Q
Sbjct: 265 IHRIQELERSLSELKNQMAKPPSL--APPAVTSVVEQLQDEAKHLRQE-VEGLEGKLQSQ 321
Query: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE-EKMREEERMREREKKMREEEEMMREQ 608
E + +Q++R+ QEQE+ +QE +++RE+ER+ E+ +++RE+++ ++EQ
Sbjct: 322 VENNQALSLLSKEQKQRL----QEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQ 377
Query: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
E++++QE+++++QEE++ ++EE++Q+QE+++W+QEE++W++EE++ +Q E++ L
Sbjct: 378 GERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQ----EERLALS 433
Query: 669 EHEKMQEQ-EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
++ K+ +Q + Q E + ++K + ++Q K+ QEK+ EE ++ + E +
Sbjct: 434 QNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKEL--QEKLDEEHLEAASQQNQQLETQ 491
Query: 728 MMREQEEKMQEQEEKMQEQEEE 749
+ + + + +EEE
Sbjct: 492 LSLVALPGEGDGGQHLDSEEEE 513
Score = 117 bits (293), Expect = 5e-26
Identities = 84/350 (24%), Positives = 184/350 (52%), Gaps = 37/350 (10%)
Query: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE--------KMREEERMREREK 596
Q+ E E ++ Q++++ Q E +K E K ++ E K + + ++
Sbjct: 87 QLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKR 146
Query: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
R EE ++ ++Q +++QE E + + QE++ +E + + ++ +
Sbjct: 147 AARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIK 206
Query: 657 QQRL-----PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711
++ L + E L + + +++ + E+ QE+M K + E +T +EK R+
Sbjct: 207 ERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEA--RTLKEEKKRD 264
Query: 712 EESMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
++E E+ + E + M + E++Q++ + ++++ E + + + E
Sbjct: 265 IHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVEN 324
Query: 761 EEKMW-----EQQRLPEQKEKLWEHE--KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813
+ + ++QRL EQ+E L E E +++EQE++ EQ E++R+Q++ ++ Q E++R Q
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
E+++R QEE++ +EE++ QE+++W QEE++W K EE++Q QEE++
Sbjct: 385 EQRLRKQEERLRKEEERLQKQEKRLWDQEERLW----KKEERLQKQEERL 430
Score = 103 bits (258), Expect = 5e-22
Identities = 95/421 (22%), Positives = 209/421 (49%), Gaps = 56/421 (13%)
Query: 421 EQVEKMREEKKMQEQE----KKTRDQEEKMQEE--ERIREREKKMREEEETMREQEEKMQ 474
E +E ++++KK E + KKT ++ K Q E E I + + + T+ + +
Sbjct: 90 ENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAAR 149
Query: 475 KQEENMWEQEEK-EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
EE + + ++ QR+ E + L Q++E++ E + + +++
Sbjct: 150 HFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERA 209
Query: 534 WRQEKMREQEDQMWEQEEKMRDQ-------EQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
+ + + + +Q + RD+ E+ W +ERM K + E +EEK R
Sbjct: 210 LLNAHVTQVTESL-KQVQLERDEYAKHIKGERARW--QERMWKMSVEARTL---KEEKKR 263
Query: 587 EEERMREREKKMREEEEMMREQE-----------EKMQEQEEKMQEQEE----KMWEQEE 631
+ R++E E+ + E + M + E++Q++ + ++++ E K+ Q E
Sbjct: 264 DIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVE 323
Query: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Q EQ++++ EQEE + EQ E ++++EQE++ EQ E++ EQ+K
Sbjct: 324 NNQALSLLSKEQKQRLQEQEEMLREQ-----------EVQRVREQERLCEQNERLREQQK 372
Query: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW 751
++ E+ +K +Q ++EE +R+ E++++++E+ + +QEE++ ++EE++Q+QEE +
Sbjct: 373 TLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERL- 430
Query: 752 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK---MQEQEKIWEQEEKMRDQEEKMRGQEE 808
Q K+ +Q P+ + +EK +Q ++++ E +EK+ ++ + Q+
Sbjct: 431 -----ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQQN 485
Query: 809 K 809
+
Sbjct: 486 Q 486
Score = 91.7 bits (226), Expect = 3e-18
Identities = 76/353 (21%), Positives = 177/353 (50%), Gaps = 30/353 (8%)
Query: 550 EEKMRDQEQKMWDQEERMEK--------KTQEQEKKTWDQEEKMREEERMREREKKMREE 601
EE+ +D ++ +R+++ TQ+QE+ D+ RE R ++ ++E
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALCAVSTQQQEE---DRSSSCREAVLHRRLQQTIKER 208
Query: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE-EKMWEQEEKMWEQQRL 660
+ + + ++ E++E + + +E+MW+ E +EEK + R+
Sbjct: 209 ALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRI 268
Query: 661 PEQKEKLWE--HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
E + L E ++ + + EQ + E K QE + + + + E+ +
Sbjct: 269 QELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQAL 328
Query: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQKEKL 777
+E+++ ++EQEE ++EQE + ++E + EQ E++ EQ++ + EQ +RL +Q+++L
Sbjct: 329 SLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRL 388
Query: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK 837
+ QE+ ++EE+++ QE+++ QEE++ +EE+++ QEE++ Q K
Sbjct: 389 ----RKQEERLR-KEEERLQKQEKRLWDQEERLWKKEERLQKQEERL------ALSQNHK 437
Query: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
+ +K + + E + +++ + E++++ +EK+ E+ + Q+ +
Sbjct: 438 L----DKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQQNQ 486
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 239 bits (611), Expect = 6e-63
Identities = 181/725 (24%), Positives = 398/725 (54%), Gaps = 65/725 (8%)
Query: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFL 261
L K + + LE T+ E KK+ + +K P + + + V ++KR++ +
Sbjct: 1367 LKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKE--- 1423
Query: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
+ +M + EE+ E+K+ KQE K+ E Q+ K K W + K
Sbjct: 1424 ---------ERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWK------KAWDEWK 1468
Query: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
++ + ++ + KE +K L ++EE++ + EK+ +EE ++E ++ W + +++WE
Sbjct: 1469 QVHGETRKSWKAWKE-EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWEN 1527
Query: 382 EKQMREQEQKMRDQEE--------RMWEQDERLREKEERMREQEKMWEQV--EKMREEKK 431
+ +EQ+ +D+EE R E+ E+ +E+R ++E W ++ ++ R EKK
Sbjct: 1528 MLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKK 1587
Query: 432 MQEQEKKTRDQEEKMQEEERIREREK--------KMREEEETMREQEEKMQKQEENMWEQ 483
++E+K +EEK+ +EER +E+ K+ +++ M + E K ++EE + ++
Sbjct: 1588 RAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQR 1647
Query: 484 EEKEWQQ-QRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQ--EKKMWRQEKM 539
EK Q+ ++L ++++KL ++ EK+ +EEK+ ++ K+ + + + Q E+ R++ +
Sbjct: 1648 GEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL 1707
Query: 540 REQEDQMWEQEEKMR-DQEQKMWDQEE--RMEKKTQEQEKKTWDQEEKMR-EEERMRERE 595
QE ++ ++ E++ D E+ W +EE + E K E++KK ++EE + + E++ E E
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767
Query: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
K+ +EEE++ +++EK+ + +EKM E+EE++ + E++ E++ K+ ++ E+ E++
Sbjct: 1768 TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELT 1827
Query: 656 EQQRLPEQKEKLWEHEK--MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM-REE 712
+ + + QK+ L + +K QE+EK+ +++E + + E+ T +++ + K+
Sbjct: 1828 KNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNK--ERLTHSKKQLVQVKNKLGMFN 1885
Query: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPE 772
+ + + E+K+ +E+E + +++EK+ E E+K+ + E+ + +++EK+ +++ K+ ++ + +
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ 1945
Query: 773 QKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR---GQEEKMRGQ------EEKMRGQEEK 823
K++L + ++EK E K R EEKMR G+E +G+ + KM E++
Sbjct: 1946 GKKRLRGELDIAKEEKALNLEMK-RLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE 2004
Query: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
++ E+ EEK+ E+++ EE E +G+ E R Q ++GQ + + +
Sbjct: 2005 LF---ERKLSLEEKILLHEDRILAMEE--SEIAKGKLEFTRGQRIFVQGQRKLAKASRKL 2059
Query: 884 MRGQE 888
++ +E
Sbjct: 2060 IKKRE 2064
Score = 226 bits (575), Expect = 1e-58
Identities = 192/776 (24%), Positives = 410/776 (52%), Gaps = 113/776 (14%)
Query: 231 QEKLPLAESEKSEIQLNVKELK--RKLERAKFLLPQVQTNTLQ--EEMWRQEEELREQEK 286
QE+ LA+ E+ Q VK + R++ +A+ Q + Q E++ ++ E+L ++ K
Sbjct: 1604 QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
Query: 287 KIRKQEEKMWRQEERLREQEGKMREQE-------EKMWRQEKRLREQEKELREQEKELR- 338
K+ K+ EK+ R+EE+L ++ GK+ E + E++ ++E+ L QEKEL ++ +EL
Sbjct: 1664 KLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEW 1723
Query: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
+ +EL +EE++ ++E K+ E+++K+ E+EE + Q E+L E+E ++ ++E+ + ++E+
Sbjct: 1724 DMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEK 1783
Query: 399 MWEQDERLREKEERM-REQEKMWEQVEKMREEK-------------KMQEQEKKTRDQEE 444
+ + E++ E+EER+ R++E++ E+ K+ +++ KM +KK QE+
Sbjct: 1784 LAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEK 1843
Query: 445 K--MQEEERIRER-----------------------------------EKKMREEEETMR 467
K QE+E++ +R E+K+ +E+ET+
Sbjct: 1844 KNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVI 1903
Query: 468 EQEEKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
+++EK+ + E+ + + E+ +Q++L ++K KL EK Q +K E I +E+
Sbjct: 1904 KKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKA 1962
Query: 527 WGQEKKMWRQEKMR---------EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
E K +EKMR + E ++ KM EQ++++++ +E+K E +
Sbjct: 1963 LNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDR 2022
Query: 578 TWDQEEK----------------MREEERMREREKKMREEEEMMREQEEKMQE---QEEK 618
EE ++ + ++ + +K+ ++ E + ++ K+ + +K
Sbjct: 2023 ILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQK 2082
Query: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM----WE----QQRLPEQKEKLWEH 670
+ E K+ ++E KM + + ++ +E ++ ++ K+ W+ + L + ++KL
Sbjct: 2083 LTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARK 2142
Query: 671 EKM--QEQEKMQEQEEKIWEQE-KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
++ + +M +EEK+ E+E K+ +K E ++ + EEE + +++ R+ +E
Sbjct: 2143 QRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKE 2202
Query: 728 MMR--EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
R + +EK Q +++ E EE E+ E + ++ EK Q+ L ++E+ E E+ +E
Sbjct: 2203 AKRGDKPKEKFSSQVDEV-ESEEHFSEEMESLLDELEK---QESLSSEEEEEREEEEERE 2258
Query: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE-EKMWGQEEKMWGQEE- 843
+E++ E+EE+ +++EE Q EK +++K + +++K QE E+++ ++E++ +EE
Sbjct: 2259 EEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEET 2318
Query: 844 KMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK-MRGQEEKIYCVGSPP 898
+ EE+ EE +EE RE+E + ++ K++EQ K +RG+E + + P
Sbjct: 2319 ESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVP 2374
Score = 223 bits (568), Expect = 6e-58
Identities = 171/707 (24%), Positives = 385/707 (54%), Gaps = 51/707 (7%)
Query: 221 EELKKKNAELQEKLPLAESEKS-EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 279
EE +K+ + +EKL A + S E ++ ++ K K E K + + ++ +E+ ++ EE
Sbjct: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEE 1542
Query: 280 ELREQEKKIRKQEEKMWR--QEERLREQEGKMREQEEKMWRQEKRLREQEKEL-REQEKE 336
E+ +E+ R+ EEK + +E+R ++E K K R EK+ ++E++L +E+EK
Sbjct: 1543 EVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL 1602
Query: 337 LREQKELREQE--------------EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
+E+++L ++E +M + E K ++EE + ++ EK+ ++ E+L ++
Sbjct: 1603 AQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKR 1662
Query: 383 KQMREQEQKMRDQEERMWEQDERLRE---------KEERMREQEKMWEQVEKMREEKKMQ 433
K++ ++ +K+ +EE++ ++ +L E +E REQ W++ E +E ++++
Sbjct: 1663 KKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELE 1722
Query: 434 -EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
+ E+ + +EE QEE ++ E +KK+ EEEE + Q EK+ ++E + ++EE
Sbjct: 1723 WDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE------L 1776
Query: 493 LPEQKEKLWE-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
L ++KEKL + +EKM E+EE++ + E++ +++ Q+++ W +++M ++
Sbjct: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK 1836
Query: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
K QE+K QE+ EK Q +E +++E ++++ + + K+ +++ + EEK
Sbjct: 1837 KNLAQEKKNLAQEK--EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEK 1894
Query: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
+ +++E + +++EK+ E E+K+ + E+ + +++EK+ +++ K+ ++ + + K++L
Sbjct: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954
Query: 672 KMQEQEKMQEQEEKIWEQEKM------EKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
+ ++EK E K +EKM E ++ + +T Q KM + E E+K+ E
Sbjct: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVE-QELFERKLSLE 2013
Query: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR-LPEQKEKLWEHEKMQ 784
E+++ ++ + +E ++ + + E + + + K+ + R L +++E L ++
Sbjct: 2014 EKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESL--SKEPA 2071
Query: 785 EQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK 844
+ KI + +K+ E K+ +E KM + + +E ++ ++ K+ + K W EK
Sbjct: 2072 KLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL---DIKEWDFSEK 2128
Query: 845 MWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+ K E+K+ ++ K+ + +M +EEKM E+E K+ + ++
Sbjct: 2129 R-SELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEV 2174
Score = 219 bits (559), Expect = 7e-57
Identities = 158/638 (24%), Positives = 358/638 (56%), Gaps = 58/638 (9%)
Query: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK----MREQEEKMWRQEKRLREQ 326
QE + +E RE+E+ +K + + +E ++ ++GK + M ++ + E+
Sbjct: 1334 QEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEK 1393
Query: 327 ---EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
+K ++ K +++++++ + + +M ++E M E+ E+M EEK+ +QE +L E+
Sbjct: 1394 KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Q+ K + W++ +++ + R+ K W++ EK++ ++E+K
Sbjct: 1454 TPSWQDWK------KAWDEWKQVHGET---RKSWKAWKE----EWEKRLLQEEEKLHQAG 1500
Query: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
EK+ EE + + +KK++ EE ++ ENM + KE Q+ +++E E+
Sbjct: 1501 EKLSPEEEMLQEDKKLKWEE---------WKQVWENMLSSKSKE---QQYKDEEEVTLEE 1548
Query: 504 EKMQEQEEK---IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
E +E EEK + E++ I+++ + +K R EK R QE++ QEE+ QE++
Sbjct: 1549 EVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ 1608
Query: 561 WDQEER-----MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
QEER K TQ+ + + + ++EE + +R +K+ +E E + ++ +K+ ++
Sbjct: 1609 LAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKK 1668
Query: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM-WEQQRLPEQKEKL-WEHEKM 673
EK+ +EEK+ ++ K+ E + + ++ E++ ++E+ + W+++ L ++ E+L W+ E++
Sbjct: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728
Query: 674 Q-EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
++E++ ++E K+ E++K K +E+E W +EK+ EEE+ K+ +EEE++ ++
Sbjct: 1729 SWKEEELNQEEGKLVEEKK--KLAEEEEALAWQREKLSEEET------KLAQEEELLIQE 1780
Query: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQEQEKIWE 791
+EK+ + +EKM E+EE + + E++ E++ K+ +++R E+L +++ + Q+K
Sbjct: 1781 KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLA 1840
Query: 792 QEEK-MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE 850
QE+K + ++EK+ ++E + +E++ ++++ + K+ G K+ Q E+ QE+
Sbjct: 1841 QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL-GMFNKILAQVEEKLTQEK 1899
Query: 851 ----KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
K +EK+ E+K+ + E+ + ++EK+ +++ K+
Sbjct: 1900 ETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
Score = 211 bits (538), Expect = 2e-54
Identities = 173/730 (23%), Positives = 373/730 (51%), Gaps = 117/730 (16%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALS-----LELYRNTITN--EEL--KKKNAEL 230
+L + ++ + KK + E++ +E + L+ L +N + EEL +++N +
Sbjct: 1650 KLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDW 1709
Query: 231 QEKLPLAESEKSEI---QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 287
QEK E E+ E +L+ KE + E K + + + +E + Q E+L E+E K
Sbjct: 1710 QEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETK 1769
Query: 288 IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK-------ELREQ 340
+ ++EE + +++E+L + + KM E+EE++ R+ ++L E++ +L ++ + EL +
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN 1829
Query: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM--------------R 386
K + Q++ + ++++ + +++EK+ +++E + +ERL +KQ+
Sbjct: 1830 KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILA 1889
Query: 387 EQEQKMRDQEERMWEQDERLREKEERM--------REQEKMWEQVEKMREEKKMQEQEKK 438
+ E+K+ ++E + ++ E+L E E+++ ++QEK+ ++ K+ EK M + +K+
Sbjct: 1890 QVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949
Query: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQK 497
R + + +EE+ + K++ EE+ + E +E + K E ++ K Q +Q L E+K
Sbjct: 1950 LRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERK 2009
Query: 498 EKLWEQEKMQEQEEKIWEQEEK----------------IRDQEEMWGQEKKMWRQ----- 536
L +EK+ E++I EE ++ Q ++ +K+ ++
Sbjct: 2010 LSL--EEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLS 2067
Query: 537 -------------EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
+K+ E ++ ++E KM ++ ++ +E R+ + + + K WD E
Sbjct: 2068 KEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE 2127
Query: 584 KMRE----EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW---EQEEKMQEQ 636
K E E+++ +++K+ + M +EEKM E+E K+ + ++ E+E ++E+
Sbjct: 2128 KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEE 2187
Query: 637 E-----EKMWEQ----------EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
E ++ W + +EK Q +++ ++ E+ E L + + QE +E
Sbjct: 2188 EVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEE 2247
Query: 682 QEEKIWEQEKMEKKTQEQEKKTWDQE----KMREEESMREREKKMREEEEMMREQEEKMQ 737
+EE+ E+E+ E++ +E+E++ ++E K E+E +++KK +++E ++E+EE +
Sbjct: 2248 EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFE 2307
Query: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
E+EE M E+E E EE E+EE ++ + +KE L K ++Q K+ EQ K
Sbjct: 2308 EKEEIMSEEETESLSDEE---EEEESCSLEEEVDREKEIL----KKEKQFKLQEQRRK-- 2358
Query: 798 DQEEKMRGQE 807
+RG+E
Sbjct: 2359 ----SLRGRE 2364
Score = 209 bits (532), Expect = 9e-54
Identities = 170/702 (24%), Positives = 367/702 (52%), Gaps = 91/702 (12%)
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL-QEKLPLAES 239
L + + + R + D +EL +E + L ++ + EEL ++ +L +EK LAE
Sbjct: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-KIRKQEEKMWRQ 298
E++ L Q + + +E QEEEL QEK K+ + +EKM +
Sbjct: 1753 EEA------------------LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE 1794
Query: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
EERL + ++ E++ K+ ++ +R +EL + + L ++K L ++++ + +++EK+
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
Query: 359 EQEEKMREQEEKMWRQEERLWEQE-------KQMREQEQKMRDQEERMWEQDERLREKEE 411
+++E + +E++ +++L + + K + + E+K+ ++E + ++ E+L E E+
Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Query: 412 RM--------REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463
++ ++QEK+ ++ K+ EK M + +K+ R + + +EE+ + K++ EE+
Sbjct: 1915 KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEK 1974
Query: 464 ETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEKMQEQEEKIWEQEEK--- 519
+ E +E + K E ++ K Q +Q L E+K L +EK+ E++I EE
Sbjct: 1975 MRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL--EEKILLHEDRILAMEESEIA 2032
Query: 520 -------------IRDQEEMWGQEKKMWRQ------------------EKMREQEDQMWE 548
++ Q ++ +K+ ++ +K+ E ++ +
Sbjct: 2033 KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ 2092
Query: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK----MREEERMREREKKMREEEEM 604
+E KM ++ ++ +E R+ + + + K WD EK ++E+++ +++K+ +
Sbjct: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRR 2152
Query: 605 MREQEEKMQEQEEKM-QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
M +EEKM E+E K+ ++ E + + EE+ +EE++ ++ W + + E +R +
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK---EAKRGDKP 2209
Query: 664 KEKLWEH-EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722
KEK ++++ +E E+ E + ++ + ++ +E++ ++E+ REEE +RE E++
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 723 REEEEMMREQEEKMQEQ--EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
+EEEE +Q EK +E+ ++K ++++EE+ E+EE E+EE M E E+ E L +
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE-----EETESLSDE 2324
Query: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK-MRGQE 821
E +E+E +EE R++E + ++ K++ Q K +RG+E
Sbjct: 2325 E--EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
Score = 202 bits (514), Expect = 1e-51
Identities = 164/600 (27%), Positives = 317/600 (52%), Gaps = 64/600 (10%)
Query: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
L+++ K L E + + + +++ ++ QE +RE + QE + +E RE+E
Sbjct: 1294 LKKESKVLLEDLDW----DVVPPEKKPIFIQEGAIREDMIQGVTQEV-IRHKEVMPREEE 1348
Query: 390 QKMRDQEERMW-EQDERLREKEERMREQEK----MWEQVEKMREEKKMQEQEKKTRDQEE 444
Q + + + E+ + + +K +++ E M +++ K E+K Q+ K+ R +
Sbjct: 1349 QAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQ 1408
Query: 445 KMQEEERIR----EREKKMREEEETMREQEEKMQKQEENM-----------WEQEEKEWQ 489
K ++ +I+ + E+ M EE E M EEK+ KQE + W++ EW+
Sbjct: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
Query: 490 QQRLPEQKE-KLWEQE---KMQEQEEKIWEQEEKIRDQEEM--------WGQEKKMWRQE 537
Q +K K W++E ++ ++EEK+ + EK+ +EEM W + K++W
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENM 1528
Query: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER-EK 596
+ ++Q ++ EE++ +E+ + EE+ ++ T+EQ + +E K R R R EK
Sbjct: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQ--RHIQEEHKWARIHRKRARAEK 1586
Query: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
K +EE + ++EEK+ ++E ++ ++E K+ + K+ + + +M + E K ++EE
Sbjct: 1587 KRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEE---- 1642
Query: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716
L ++ EKL QE EK+ ++ +K+ +K EK +E+EK K+ E +++
Sbjct: 1643 --TLAQRGEKL-----SQEAEKLAQKRKKL--AKKWEKVAREEEKLAKKGGKLAEVKNIL 1693
Query: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
+ + EE REQ QE +E QE EE W+ EE W++EE E+ +L E+K+K
Sbjct: 1694 AQ----KVEELPQREQNLDWQE-KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK 1748
Query: 777 LWEHEK--MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834
L E E+ ++EK+ E+E K+ +EE + ++EK+ +EKM +EE++ + E++ +
Sbjct: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
Query: 835 EEKMWGQEEKMW--GQEEKMEEKMQGQEEKMREQEEKMRGQE-EKMREQEEKMRGQEEKI 891
+ K+ Q+ + W EE + KM ++K QE+K QE EK+ +++E + +E++
Sbjct: 1809 KMKL-AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
Score = 144 bits (364), Expect = 3e-34
Identities = 152/644 (23%), Positives = 309/644 (47%), Gaps = 116/644 (18%)
Query: 193 KKADRYI---EELTKERDAL----SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQ 245
+K +R+I EELTK + L +L + + E K+K A+ +E L + + +
Sbjct: 1814 QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQE--KEKLAQRKENLLYNKERLTHSK 1871
Query: 246 LNVKELKRKLERAKFLLPQVQTNTLQEE--MWRQEEELREQEKKIRKQEEKMWRQEERLR 303
+ ++K KL +L QV+ QE+ + +++E+L E EKK+ + E+ + +++E+L
Sbjct: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLA 1931
Query: 304 EQEGKMREQEEKMWRQEKRLR------EQEKELREQEKELREQK--------ELREQEEQ 349
+++ K+ E+ M + +KRLR ++EK L + K L E+K L + E
Sbjct: 1932 QEKMKLA-LEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP 1990
Query: 350 MQEQEEKMWEQEEKMREQ----EEKMWRQEERLWEQEK---------------------- 383
++ KM + E+++ E+ EEK+ E+R+ E+
Sbjct: 1991 ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQR 2050
Query: 384 -------------------------------QMREQEQKMRDQEERMWEQDERLREKEER 412
++ E+K+ +E +M + L KE R
Sbjct: 2051 KLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERR 2110
Query: 413 MR-EQEKM----WEQVEKMRE----EKKMQEQEKKTRDQEEKM-QEEERIREREKKM-RE 461
+ EQ K+ W+ EK E EKK+ +++K ++ +M +EE++ E E K+ R+
Sbjct: 2111 LSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARK 2170
Query: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ----KEKLWEQEKMQEQEEKIWEQE 517
E + + EE+ +EE + ++ W++++ ++ KEK Q E EE E+
Sbjct: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEM 2230
Query: 518 EKIRDQ---EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574
E + D+ +E E++ R+E+ +E+++ E+EE+ +++E+ +E+++EK+ +E+
Sbjct: 2231 ESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEE---GEEKQVEKEEEEK 2287
Query: 575 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM----QEQEEKMQEQEEKMWEQE 630
+KK +K +++E ++E+E+ E+EE+M E+E + +E+EE +EE E+E
Sbjct: 2288 KKK-----KKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKE 2342
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQR-LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
+E++ K+ EQ K E++ R +P K + + + +++ E
Sbjct: 2343 ILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVL--KSPLKKLMSTALEM 2400
Query: 690 EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
++ +++ +W+ +K E R+ M +E E+M + E
Sbjct: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYE 2444
Score = 125 bits (314), Expect = 2e-28
Identities = 113/468 (24%), Positives = 238/468 (50%), Gaps = 56/468 (11%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
+++ AL + KK R ++ KE AL+LE+ R E K + E +E L E+
Sbjct: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLA----EEKMRLVEGKETLSKGET 1989
Query: 240 EKSEIQLNVKELKRKL-ERA-----KFLLPQVQTNTLQE--------EMWRQEEELREQE 285
++ Q + +++++L ER K LL + + ++E E R + + +
Sbjct: 1990 PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ 2049
Query: 286 KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE 345
+K+ K K+ ++ E L ++ K+ + + + +K R++ K +E+ K + ++ L
Sbjct: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKAL---QKLTRDERKLTQEEIKMTKMKRALFV 2106
Query: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 405
+E ++ ++ K+ +E E+ ++ + E++L +++++ + ++M ++EE+M E++ +
Sbjct: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
Query: 406 LREKEERM---REQEKMWEQVEKM----REEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
L K + E+E E+ E + R +K +E ++ + +E+ + + + E E+
Sbjct: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV-ESEEH 2225
Query: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
EE E++ ++ EK + E+EE+E +++R E+E+++E+EE+ E+EE
Sbjct: 2226 FSEEMESLLDELEKQESLSSE--EEEEREEEEER---------EEEEVREEEEERKEEEE 2274
Query: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Q E +EKK ++EK +E ++ E+EE ++E+ M EE E + E+E
Sbjct: 2275 GEEKQVEKEEEEKKKKKKEKKKE---EVQEKEEVFEEKEEIM--SEEETESLSDEEE--- 2326
Query: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
EEE E+ RE+E + +E++ K+QEQ K E++
Sbjct: 2327 --------EEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
Score = 43.1 bits (100), Expect = 0.001
Identities = 70/391 (17%), Positives = 163/391 (41%), Gaps = 53/391 (13%)
Query: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
+E ++ + + +++ Q KK ++ +R ++ +ER+ K E + E E +
Sbjct: 1070 EESEVAIKPSKGQRRGQAGVKK--HSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAA 1127
Query: 616 EEKMQEQEE-KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ--QRLPEQKEKLWEHEK 672
+M+E W + + + + QE+ + + + + Q++ ++++K +K
Sbjct: 1128 PIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQK 1187
Query: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE----EEEM 728
++++ K + +E K+ +E EQ + + R + R + +++
Sbjct: 1188 LKKKHKKKGKEAKVINEETTPP-VMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDL 1246
Query: 729 MREQEEKMQEQEEKMQEQ--------EEEMWEQEEKMWE----------QEEKM------ 764
R ++ + KM E +EM WE +E K+
Sbjct: 1247 CRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLD 1306
Query: 765 WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM 824
W+ +P +K+ ++ E ++ I +++ +E M +EE+ + + M G EE
Sbjct: 1307 WDV--VPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQ 1364
Query: 825 W----GQE------------EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ-EEKMREQE 867
G++ +++ +EEK Q+ G++ +E+ G+ + +M ++E
Sbjct: 1365 VILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEE 1424
Query: 868 EKMRGQEEKMREQEEKMRGQEEKIYCVGSPP 898
M + E+M EEK+ QE K+ + P
Sbjct: 1425 RDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
sapiens]
Length = 1002
Score = 219 bits (559), Expect = 7e-57
Identities = 196/731 (26%), Positives = 352/731 (48%), Gaps = 91/731 (12%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
+ Q+ QL+EEKK HQ Q ALR +++ TI IL +K EL+TAL ++Q AAR+ E
Sbjct: 189 QQNQEITDQLEEEKKECHQKQGALREQLQVHIQTIGILVSEKAELQTALAHTQHAARQKE 248
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
GES+DLA RL +S GEL+RALSAVS
Sbjct: 249 --------------------------------GESEDLASRLQYSRRRVGELERALSAVS 276
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249
T+ KKADRY +ELTKERDAL LELY+NT +NE+LK++ +EL+EKL + +EK+ +QLN++
Sbjct: 277 TQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLE 336
Query: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
EL++KLE + LL Q + + +Q ++ E+ ++ ++ +L+ + K
Sbjct: 337 ELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKY 396
Query: 310 REQ---EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
E E MWRQ + +++ EQ LRE+KE ++QE E + E +M E
Sbjct: 397 AENLKGESAMWRQ------RMQQMSEQVHTLREEKEC--SMSRVQELETSLAELRNQMAE 448
Query: 367 QEEK-----MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL----REKEERMREQE 417
E++L + + +R++ + + Q + + +E L RE+EER+ E E
Sbjct: 449 PPPPEPPAGPSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELE 508
Query: 418 K---MW-EQVEKMREEKKMQEQEKKT--RDQEEKMQEEERIREREKKMREEEETMREQEE 471
+ +W EQ E R+ + + ++ T R + + +E++ E + + E
Sbjct: 509 RAAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITS 568
Query: 472 KMQKQEENMWEQEEKEWQ-QQRLPEQKE----KLWEQEKMQEQEEK-IWEQEEKIRDQEE 525
+Q ++ E +K + Q++L E KE K E + +Q+Q ++ + ++ + ++
Sbjct: 569 ALQSEQHVKRELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQ 628
Query: 526 MWGQEKKMWRQEKMREQ-EDQMWEQEEKMRD----QEQKMWDQEERMEKKTQEQEKKTWD 580
+ +++ + Q ++ Q DQ+ +QE + + Q++ + +ER+E TQ+ ++
Sbjct: 629 LTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQ 688
Query: 581 QEEKMREEE---RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
E RE E+ EEEE + M E ++ +E + + E
Sbjct: 689 LSLMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAE 748
Query: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE-----------------HEKMQ-EQEKM 679
E+ ++ EQ + L +K E H +Q EK+
Sbjct: 749 EEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKL 808
Query: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Q + ++ QEK + K + +E + + E +++ E + + +++E+ + +E
Sbjct: 809 QSRFMELM-QEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEY 867
Query: 740 EEKMQEQEEEM 750
++ + +EEM
Sbjct: 868 ISRLAQDKEEM 878
Score = 195 bits (495), Expect = 2e-49
Identities = 210/840 (25%), Positives = 381/840 (45%), Gaps = 107/840 (12%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP LPP P MSE+TRQ+KLA AKKK +Y+Q N GV TGA KKKKI +G+NPET
Sbjct: 1 MWPQPRLPPRPAMSEETRQSKLAAAKKKLREYQQRNSPGVPTGA--KKKKKIKNGSNPET 58
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TTSGGCHSPEDT ++ A + L + + ++ T + + +
Sbjct: 59 TTSGGCHSPEDTPKDNAATLQP-----SDDTVLPGGVPSPGASL-------TSMAASQNH 106
Query: 121 SQDAARKFEDGNLGTPSSFNL-ALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAG 179
D D S+ +L LSQ G L C S + + GE + L
Sbjct: 107 DADNVPNLMDETKTFSSTESLRQLSQQLNG--LVCESATCVNGEGPASSANLKDLESRYQ 164
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP---- 235
+L AL + +K+ + IE+L ++ ++ +L +E +K L+E+L
Sbjct: 165 QLAVALDSSYVTNKQLNITIEKLKQQNQEITDQLEEE---KKECHQKQGALREQLQVHIQ 221
Query: 236 ---LAESEKSEIQLNVKE----LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI 288
+ SEK+E+Q + ++K ++ L ++Q + R+ EL +
Sbjct: 222 TIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSR------RRVGELERALSAV 275
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK---ELRE 345
Q++K R + L ++ +R + K + + L++++ EL E+ + L +K +L
Sbjct: 276 STQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNL 335
Query: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ-EQKMRDQEERMWEQD- 403
+E Q + + ++ Q+ R + +Q ++ E+ Q+ Q M + E+D
Sbjct: 336 EELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDK 395
Query: 404 --ERLREKEERMREQ-EKMWEQVEKMREEK-----KMQEQEKKTRDQEEKMQEEERIRER 455
E L+ + R++ ++M EQV +REEK ++QE E + +M E E
Sbjct: 396 YAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPP-PEP 454
Query: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515
E E+ ++ + E ++K+ E + Q + + Q E +L +EQEE++ E
Sbjct: 455 PAGPSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDN---EGLSRL-----NREQEERLLE 506
Query: 516 QEEKIRDQEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
E E+WG++ + RQ E M+ + + R+ ++++ + + K T E
Sbjct: 507 LER----AAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNE 562
Query: 574 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKM 633
+ T ++ E+ + RE +K+ E +EK+ E +E + E K
Sbjct: 563 NMEIT-----------------SALQSEQHVKRELGKKLGELQEKLSELKETV---ELKS 602
Query: 634 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
QE + ++++ + ++ + Q+L +KE L H ++ Q ++ +Q + +QE
Sbjct: 603 QEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVL--HNQLLLQTQLVDQ---LQQQEAQG 657
Query: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQ 753
K E ++ + + R E + ++ ++ + M E ++EE+ E+EEE
Sbjct: 658 KAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHPGEGDGLDREEEEDEEEEE---- 713
Query: 754 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE--QEKIWEQEEKMRDQEEKMRGQEEKMR 811
EE + Q +P E L E M + EE ++ ++RGQ ++ R
Sbjct: 714 -------EEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEE----EQARLRGQLKEQR 762
Score = 65.1 bits (157), Expect = 3e-10
Identities = 85/443 (19%), Positives = 199/443 (44%), Gaps = 48/443 (10%)
Query: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
EK+++Q + + +Q L E+K++ +++ ++ ++ Q I E+ Q
Sbjct: 185 EKLKQQNQEITDQ---------LEEEKKECHQKQGALREQLQVHIQTIGILVSEKAELQT 235
Query: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER 590
Q R++E + + +++ +++ + E + + +Q+K +E +E +
Sbjct: 236 ALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA 295
Query: 591 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
+R K + E +++++ +++E+ + ++ M E++Q K E E + +Q
Sbjct: 296 LRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLEELQ----KKLEMTELLLQQ 351
Query: 651 EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
E P+ ++L + M+E+ +++ ++ ME Q Q ++ E ++
Sbjct: 352 FSSRCEA---PDANQQL--QQAMEERAQLEAHLGQV-----MESVRQLQMERDKYAENLK 401
Query: 711 EEESM-REREKKMREEEEMMREQEE----KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
E +M R+R ++M E+ +RE++E ++QE E + E +M E
Sbjct: 402 GESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEV 461
Query: 766 EQQRLPEQKEKLWEHE--------KMQEQEKI----WEQEEKMRDQEE--KMRGQEEKMR 811
EQQ E + E E ++Q+ E + EQEE++ + E ++ G++ + R
Sbjct: 462 EQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGEQAEAR 521
Query: 812 GQ----EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867
Q + R + Q ++ Q ++ K+ + ++ +Q ++ RE
Sbjct: 522 RQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVKRELG 581
Query: 868 EKMRGQEEKMREQEE--KMRGQE 888
+K+ +EK+ E +E +++ QE
Sbjct: 582 KKLGELQEKLSELKETVELKSQE 604
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 205 bits (521), Expect = 2e-52
Identities = 167/480 (34%), Positives = 247/480 (51%), Gaps = 91/480 (18%)
Query: 1 MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPET 60
MWPQP LPPHP MSEKT+Q KLA AKKK Y Q G+ GA +KKK+N G++P+T
Sbjct: 1 MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGA--NRKKKVN-GSSPDT 57
Query: 61 TTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY 120
TSGG HSP D+ + E A T++ L Q EL AL
Sbjct: 58 ATSGGYHSPGDS-----------------ATGIYGEGRASSTTLQDLESQYQELAVAL-- 98
Query: 121 SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
D + S ++ R S E K H H +
Sbjct: 99 ---------DSSSAIISQLTENINSLVRTSK-----------EEK------KHEIHLVQK 132
Query: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
L R+L K ++ E L E A ++ E+L+ + L+++L ES
Sbjct: 133 LGRSL------FKLKNQTAEPLAPEPPAGPSKV-------EQLQDETNHLRKEL---ESV 176
Query: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE---MWRQEEELREQEKKIRKQEEKMWR 297
++Q V+ + LL + Q L+E+ + QEE L EQE+++ +QEE++
Sbjct: 177 GRQLQAEVEN-----NQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLCE 231
Query: 298 QEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357
QEERLREQE ++REQEE++ QE+RL EQE+ L EQE+ L EQ++L Q E++ E+ EK+
Sbjct: 232 QEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLCEQEKLPGQ-ERLLEEVEKL 290
Query: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD-----ERLREKE-- 410
EQE + EQE + + ERL ++ +++ EQE ++R Q+ER+W+Q+ ERLRE E
Sbjct: 291 LEQERRQEEQERLL--ERERLLDEVEELLEQE-RLRQQDERLWQQETLRELERLRELERL 347
Query: 411 ---ERMREQEKM----WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463
ER+RE E+M WE + + R E + E+ + + +Q E++++E EK EE
Sbjct: 348 RELERLRELERMLELGWEALYEQRAEPR-SGFEELNNENKSTLQLEQQVKELEKSGGAEE 406
Score = 158 bits (399), Expect = 2e-38
Identities = 103/331 (31%), Positives = 196/331 (59%), Gaps = 21/331 (6%)
Query: 243 EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE--- 299
+++ +EL L+ + ++ Q+ T + + +EE + + ++K +++ +
Sbjct: 86 DLESQYQELAVALDSSSAIISQL-TENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQT 144
Query: 300 -ERLREQEGKMREQEEKMWRQEKRLREQEKEL-REQEKELREQKEL----REQEEQMQEQ 353
E L + + E++ + LR++ + + R+ + E+ + L R QEE+++EQ
Sbjct: 145 AEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQ 204
Query: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
EE++ EQEE++ EQEE++ QEERL EQE+++REQE+++R+QEER+ EQ+ERL E+EER+
Sbjct: 205 EERLHEQEERLHEQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERL 264
Query: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM 473
EQE+ + EK+ ++++ E+ +K +QE + +E+ER+ ERE+ + E EE + ++E++
Sbjct: 265 CEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELL--EQERL 322
Query: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE-------EKIWEQEEKIRDQEEM 526
++Q+E +W+QE + +RL E E+L E E+++E E E ++EQ + R E
Sbjct: 323 RQQDERLWQQETLR-ELERLRE-LERLRELERLRELERMLELGWEALYEQRAEPRSGFEE 380
Query: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
E K Q + + +E + E+ R E
Sbjct: 381 LNNENKSTLQLEQQVKELEKSGGAEEPRGSE 411
Score = 156 bits (394), Expect = 9e-38
Identities = 83/241 (34%), Positives = 155/241 (64%), Gaps = 15/241 (6%)
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEE 602
+Q+ ++ +R + + + Q + + Q QEE++RE EER+ E+E+++ E+E
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQE 219
Query: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
E + EQEE++ EQEE+++EQEE++ EQEE++ EQEE++ EQEE++ EQEE++ EQ++LP
Sbjct: 220 ERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLCEQEKLPG 279
Query: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKM---------EKKTQEQEKKTWDQEKMREEE 713
Q+ L E EK+ EQE+ QE++E++ E+E++ +++ ++Q+++ W QE +RE E
Sbjct: 280 QERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELE 339
Query: 714 SMREREK-----KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
+RE E+ ++RE E M+ E + EQ + + EE+ + + + E+++ E +
Sbjct: 340 RLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELE 399
Query: 769 R 769
+
Sbjct: 400 K 400
Score = 147 bits (372), Expect = 3e-35
Identities = 100/282 (35%), Positives = 169/282 (59%), Gaps = 38/282 (13%)
Query: 551 EKMRDQEQKMWDQEERMEKKTQ-EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
E+++D+ + + E + ++ Q E E R+EER+RE+E+++ E+EE + EQE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQE 219
Query: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
E++ EQEE++ EQEE++ EQEE+++EQEE++ EQEE++ EQEE RL EQ+E+L E
Sbjct: 220 ERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEE------RLCEQEERLCE 273
Query: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
EK+ QE++ E+ EK+ EQE+ +++ E+E + ERE+ + E EE++
Sbjct: 274 QEKLPGQERLLEEVEKLLEQER-----RQE-----------EQERLLERERLLDEVEELL 317
Query: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE--QE 787
++E++++Q+E +W+QE + E++ E +RL E E+L E E+M E E
Sbjct: 318 ---------EQERLRQQDERLWQQE--TLRELERLRELERLRE-LERLRELERMLELGWE 365
Query: 788 KIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
++EQ + R E++ E K Q E+ + EK G EE
Sbjct: 366 ALYEQRAEPRSGFEEL-NNENKSTLQLEQQVKELEKSGGAEE 406
Score = 140 bits (352), Expect = 7e-33
Identities = 84/276 (30%), Positives = 168/276 (60%), Gaps = 32/276 (11%)
Query: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERL----REKEERMREQEKMWEQVEKMREEKK 431
E+L ++ +R++ + + Q + E ++ L R +EER+REQE+ +
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEE------------R 207
Query: 432 MQEQEKKTRDQEEKM-QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 490
+ EQE++ +QEE++ ++EER+ E+E+++RE+EE +REQEE++ +QEE + EQEE
Sbjct: 208 LHEQEERLHEQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEE----- 262
Query: 491 QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 550
RL EQ+E+L EQEK+ Q E++ E+ EK+ +QE +++++ +E++ ++ +++ EQ
Sbjct: 263 -RLCEQEERLCEQEKLPGQ-ERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQ- 319
Query: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
E++R Q++++W QE +E + + E++RE ER+RE E+ + E + EQ
Sbjct: 320 ERLRQQDERLWQQETL-------RELERLRELERLRELERLRELERMLELGWEALYEQRA 372
Query: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
+ + E++ + + + E++++E E+ +E +
Sbjct: 373 EPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPR 408
Score = 137 bits (345), Expect = 4e-32
Identities = 82/251 (32%), Positives = 162/251 (64%), Gaps = 16/251 (6%)
Query: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKM------QEEERIREREKKMREEEETMREQE 470
E++ ++ +R+E + ++ + + +M ++EER+RE+E+++ E+EE + EQE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQE 219
Query: 471 EKMQKQEENMWEQEEK-EWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQEEMWG 528
E++ +QEE + EQEE+ Q++RL EQ+E+L EQE ++ EQEE++ EQEE++ +QE++ G
Sbjct: 220 ERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLCEQEKLPG 279
Query: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK-KTQEQEKKTWDQE----- 582
QE+ + EK+ EQE + E++E++ ++E+ + + EE +E+ + ++Q+++ W QE
Sbjct: 280 QERLLEEVEKLLEQERRQ-EEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLREL 338
Query: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
E++RE ER+RE E+ +RE E M+ E + EQ + + E++ + + + E+++ E
Sbjct: 339 ERLRELERLRELER-LRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKE 397
Query: 643 QEEKMWEQEEK 653
E+ +E +
Sbjct: 398 LEKSGGAEEPR 408
Score = 130 bits (328), Expect = 4e-30
Identities = 92/322 (28%), Positives = 183/322 (56%), Gaps = 32/322 (9%)
Query: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
+R +E + + + +++ + + K Q E + + E++++ +R+E E+
Sbjct: 116 VRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELES 175
Query: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE-KMQEQEEKIWEQEEKIRDQE 524
+ Q + + E N Q++RL EQ+E+L EQE ++ EQEE++ EQEE++ +QE
Sbjct: 176 VGRQLQA--EVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLCEQE 233
Query: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
E ++ +E++REQE+++ EQEE++ +QE+++ +QEER+ EQEK QE
Sbjct: 234 ERLREQ-----EERLREQEERLHEQEERLCEQEERLCEQEERL----CEQEKLP-GQERL 283
Query: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
+ E E++ E+E++ EE+E + E+E + E EE + ++E++++Q+E++W
Sbjct: 284 LEEVEKLLEQERRQ-EEQERLLERERLLDEVEELL---------EQERLRQQDERLW--- 330
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Q+E + E +RL E E+L E E+++E E+M E + +++ E ++ +E
Sbjct: 331 -----QQETLRELERLRE-LERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNE 384
Query: 705 DQEKMREEESMREREKKMREEE 726
++ ++ E+ ++E EK EE
Sbjct: 385 NKSTLQLEQQVKELEKSGGAEE 406
Score = 130 bits (328), Expect = 4e-30
Identities = 89/263 (33%), Positives = 155/263 (58%), Gaps = 24/263 (9%)
Query: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKM----QEQEEKMWEQEEKMQEQEEKMWEQE 644
E++++ +R+E E + Q + E + + + QEE++ EQEE++ EQEE++ EQE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQE 219
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE----KMEKKTQEQE 700
E++ EQEE RL EQ+E+L E E E+++EQEE++ EQE + E++ EQE
Sbjct: 220 ERLCEQEE------RLCEQEERLREQE-----ERLREQEERLHEQEERLCEQEERLCEQE 268
Query: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
++ +QEK+ +E + E +K+ E+E EQE + + E++ ++ EE+ EQ E++ +Q
Sbjct: 269 ERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLL--ERERLLDEVEELLEQ-ERLRQQ 325
Query: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
+E++W+Q+ L E E+L E E+++E E++ E E + E + Q + R E++
Sbjct: 326 DERLWQQETLRE-LERLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEEL-NN 383
Query: 821 EEKMWGQEEKMWGQEEKMWGQEE 843
E K Q E+ + EK G EE
Sbjct: 384 ENKSTLQLEQQVKELEKSGGAEE 406
Score = 126 bits (316), Expect = 1e-28
Identities = 83/304 (27%), Positives = 165/304 (54%), Gaps = 33/304 (10%)
Query: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE-EKMWEQEEKMQEQEEKMWEQEEKM 647
E + + +EE++ +K+ K++ Q E + + + E++ ++ +
Sbjct: 110 ENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHL 169
Query: 648 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707
++ E + Q + + ++ +++E+++EQEE++ EQE+ + EQE
Sbjct: 170 RKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEE---RLHEQE------- 219
Query: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
E + E+E+++ E+EE +REQEE+++EQEE++ EQEE + EQEE++ EQEE++ EQ
Sbjct: 220 -----ERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLCEQ 274
Query: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
++LP Q+ L E EK+ EQE+ E++E++ ++E + EE + ++E++R Q+E++W
Sbjct: 275 EKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELL--EQERLRQQDERLW-- 330
Query: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Q+E + E E + + E++RE E + E + EQ + R
Sbjct: 331 -------------QQETLRELERLRELERLRELERLRELERMLELGWEALYEQRAEPRSG 377
Query: 888 EEKI 891
E++
Sbjct: 378 FEEL 381
Score = 106 bits (264), Expect = 1e-22
Identities = 63/184 (34%), Positives = 117/184 (63%), Gaps = 17/184 (9%)
Query: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKM----QEQEEEMWEQEEKMWEQEEKMWEQQ 768
E +++ +R+E E + Q + E + + + QEE + EQEE++ EQEE
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEE------ 213
Query: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE 828
RL EQ+E+L E E E++ EQEE++R+QEE++R QEE++ QEE++ QEE++ QE
Sbjct: 214 RLHEQEERLCEQE-----ERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQE 268
Query: 829 EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
E++ ++EK+ GQE + E+ +E++ + +E++ + E++ + E++ EQE ++R Q+
Sbjct: 269 ERLC-EQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQE-RLRQQD 326
Query: 889 EKIY 892
E+++
Sbjct: 327 ERLW 330
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 183 bits (464), Expect = 7e-46
Identities = 157/635 (24%), Positives = 321/635 (50%), Gaps = 60/635 (9%)
Query: 283 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKE----L 337
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
Query: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
+Q E+ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 63 TDQVEVNAQNS-VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
D L RM+ E EK E++ ++R + +++E E + + +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEK--------EEKSESRQERYEIEETETVTKSYQ 173
Query: 458 K--MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK--MQEQEEKI 513
K R+ EE +E +EK +++EE E Q + + E+K ++E M + +I
Sbjct: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233
Query: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
+E K ++ E E + EKM E+E+K R + ++ + E E+ E
Sbjct: 234 SSEEPKQEEEREQGSDE--ISHHEKM--------EEEDKERAEAERARLEAEERERIKAE 283
Query: 574 QEKKTWDQEEKMREEERM--REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Q+KK D+ ++ EE+ +ERE++ EE E MRE+E++ E+ ++++E+E++ E+ +
Sbjct: 284 QDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
+++E+E++ E+ +++ E+E++ E+++ +E+ E K++EQ++ ++ EEK ++
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE--EKAKVEEQKRNKQLEEKKHAMQE 401
Query: 692 MEKKTQEQEKKT---WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
+ K ++ E+K W EK +E+ ++ K + EE+ + Q ++ + QE+K ++E
Sbjct: 402 TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461
Query: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE---------KMQEQEKIWEQ------- 792
E+ ++EK+ + +E E + ++K+ E + K++ E + +
Sbjct: 462 EI--KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
Query: 793 ---EEKMRDQEEKMRGQEE--KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWG 847
E + Q E + EE + RG+ E ++ K QE + +E K +E +
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 579
Query: 848 QEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+EE+ K + + K+RE+EEK R +EE R + E
Sbjct: 580 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 614
Score = 172 bits (437), Expect = 1e-42
Identities = 150/630 (23%), Positives = 309/630 (49%), Gaps = 44/630 (6%)
Query: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ----EK 233
A E +R R K+ + + ++T + + + +N++ +EE K Q ++
Sbjct: 38 ARERRRRARQERLRQKQEEESLGQVTDQVEVNA----QNSVPDEEAKTTTTNTQVEGDDE 93
Query: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
E + K L+ LER K P + +L R + + E E ++++
Sbjct: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 153
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
+ ++ + E E + ++ WR + ++++KE E+E+E ++ + E + ++ +
Sbjct: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE 213
Query: 354 EEKMWEQEEKM-------REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
E+ QEE + + E+ ++EER EQ +KM ++++ E +
Sbjct: 214 EKTTESQEETVVMSLKNGQISSEEPKQEEER--EQGSDEISHHEKMEEEDKERAEAERAR 271
Query: 407 REKEERMR----EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
E EER R + +K+ ++ ++ E+K QE++ R+ EE+ ER+RE EK+ EE
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER----ERMREEEKRAAEE 327
Query: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ---EQEEKIWEQEEK 519
+ ++E+E++ ++ + + E+E++ ++++ +++EK +E+ + E+EEK +E+K
Sbjct: 328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387
Query: 520 IRDQ--EEMWGQEKKMWRQEKMREQEDQMWEQEEKMR-DQEQKMWDQEERMEKKTQEQEK 576
Q E+ ++ + EK+ ++ + W E+K + D+ Q +++ EK T+ Q K
Sbjct: 388 RNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK 447
Query: 577 KTWDQEEK--MREEERMREREKKMRE-EEEMMREQEEKMQEQEEKMQEQE---EKMWEQE 630
+ QE+K ++EE E+ KK +E +EE+ + K E K Q E K+ E
Sbjct: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
+ + K E ++ +RL E + + E E + ++ Q+Q+E E E
Sbjct: 508 NTFSRPGGRA-SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
Query: 691 KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE---KMQEQEEKMQEQE 747
+++KK +E+ K ++E+ R++E E ++K+REEEE R +EE + E EK Q+
Sbjct: 567 ELKKKREERRKVLEEEEQRRKQE---EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP 623
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
E+ ++K ++ ++ E+ E L
Sbjct: 624 EDGLSDDKKPFKCFTPKGSSLKIEERAEFL 653
Score = 166 bits (420), Expect = 9e-41
Identities = 163/632 (25%), Positives = 302/632 (47%), Gaps = 81/632 (12%)
Query: 250 ELKRKLERAKFLLPQVQTNTL--QEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE--- 304
E +R+L R K +++ + Q +EE RE+ ++ R++ + ++EE L +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 305 -----QEGKMREQEEKMWRQEKRLREQEKEL---REQEKELREQKELREQEEQMQEQEEK 356
+ + ++E K ++ ++ R +E R QK L+E E+ +E +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 357 MWEQ--------------EEKMREQEEKMWRQEERLWEQEKQM---REQEQKMRDQEERM 399
+ + E + E+EEK ++ER +E + Q+ RD EE
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR--------DQEEKMQEEER 451
E E+ E+EE+ + QVE M EEK + QE+ EE QEEER
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
E+ E M E++++ + E E EE+E + EQ +K+ ++ E EE
Sbjct: 245 --EQGSDEISHHEKMEEEDKERAEAERARLEAEERE---RIKAEQDKKIADERARIEAEE 299
Query: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM--EK 569
K QE + R+ EE +E+MRE+E + E+ ++++++E++ ++ +R+ E+
Sbjct: 300 KAAAQERERREAEE----------RERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 570 KTQEQEKKTWDQEEKMREEERMR---EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
K +E++ +EEK EER R E E+K + EE+ ++ ++++E++ MQE + K
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQ---KRNKQLEEKKHAMQETKIK- 405
Query: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKMQEQEE 684
EK++++ E W E+K E + + ++ E+K + + EK+QE + ++EE
Sbjct: 406 ---GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE 462
Query: 685 KIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE---KKMREEEEMM-----REQEEKM 736
E+ K +K+ +E+ K D++K E + E K++ E R +
Sbjct: 463 IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK 522
Query: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE---KMQEQEKIWEQE 793
+ + E + + E + E E + +E+ + +Q+ L E K +E+ K+ E+E
Sbjct: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 582
Query: 794 EKMRDQEE---KMRGQEEKMRGQEEKMRGQEE 822
E+ R QEE K+R +EEK R +EE R + E
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAE 614
Score = 152 bits (384), Expect = 1e-36
Identities = 117/484 (24%), Positives = 250/484 (51%), Gaps = 44/484 (9%)
Query: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
M + E++ + +K +E ER R +++ E+ ++ + Q+++E
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
++ +Q E + Q + ++E K ++ +E E+ R+E+ ++ ++ E E
Sbjct: 61 QVTDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALE 116
Query: 552 KMRDQEQKMWD----------QEERMEKKTQEQEKKTWDQEEKMREEE----RMREREKK 597
+ ++ + + D Q + E +T E+E+K+ ++E+ EE ++
Sbjct: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
Query: 598 MREEEEMMREQEEKMQEQEEKM------QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
R+ EE +E +EK +E+EEK + Q E M E++ ++E + + E
Sbjct: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE 236
Query: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI-WEQEKMEKKTQEQEKKTWDQE--- 707
E E++R + +++ HEKM+E++K + + E+ E E+ E+ EQ+KK D+
Sbjct: 237 EPKQEEER-EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295
Query: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
+ E+ + +ERE++ EE E MRE+E++ E+ ++++E+E+ E+ +++ E+E++ E+
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 768 QRLPEQKEKLWEHEKM------QEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821
++ +++EK E+ +E+ K+ EQ+ + +E+K QE K++G EK+ +
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG--EKVEQKI 413
Query: 822 EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE---EKMR 878
E W E+K QE+K+ Q + Q E+ K+Q + EK++E + + +E EK++
Sbjct: 414 EGKWVNEKK--AQEDKL--QTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469
Query: 879 EQEE 882
+ +E
Sbjct: 470 KDKE 473
Score = 144 bits (364), Expect = 3e-34
Identities = 148/629 (23%), Positives = 290/629 (46%), Gaps = 90/629 (14%)
Query: 325 EQEKELREQEKE-LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
E+ +ELR Q++E +R + E + ++EE E+ + R++ + ++EE L +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Q+ Q EE E ++ E++ + E R +K++QE ++ ++ +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE--RRQKRLQEALERQKEFD 122
Query: 444 EKMQEEE-RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
+ + + R + E E+EEK + ++E +E EE E + + W
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKND---WR 178
Query: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
+ ++E+K E+EE+ + + G+ + E M E++ ++E + +
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQV----EVMVEEKTTESQEETVVMSLKNGQIS 234
Query: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
EE +++ +EQ EKM EE++ R ++ R E E E+E EQ++K+ ++
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE---ERERIKAEQDKKIADE 291
Query: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
++ E EEK QE + E EE+ E E++R E+++++ E EK + E+
Sbjct: 292 RARI-EAEEKAAAQERERREAEER----ERMREEEKRAAEERQRIKEEEK-----RAAEE 341
Query: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR----EREKKMREEEEMMREQEEK--- 735
++I E+ EK+ E+ ++ ++EK EE R E EK EE++ ++ EEK
Sbjct: 342 RQRIKEE---EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
Query: 736 MQEQE---EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKIW 790
MQE + EK++++ E W E+K E + + ++ E+K + + EK+QE + +
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF 458
Query: 791 EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE---------------------------- 822
++EE ++ +K + +E+++ ++ +G E
Sbjct: 459 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 518
Query: 823 ---------------KMWGQEEKMWGQEEKMWGQEEKMWGQEEKME----EKMQGQEEKM 863
K + + G+ E ++ K QE +E +K + + K+
Sbjct: 519 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 578
Query: 864 REQEEKMRGQEE---KMREQEEKMRGQEE 889
E+EE+ R QEE K+RE+EEK R +EE
Sbjct: 579 LEEEEQRRKQEEADRKLREEEEKRRLKEE 607
Score = 125 bits (313), Expect = 2e-28
Identities = 105/417 (25%), Positives = 209/417 (50%), Gaps = 44/417 (10%)
Query: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
++E+M+ + E+I Q D+EE + ++ RQE++R+++++ E ++ DQ
Sbjct: 14 KREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEE--ESLGQVTDQV---- 66
Query: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE---- 617
E + ++E KT ++ ++ E+ R EE + +E ++ Q+E
Sbjct: 67 --EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 618 -----------KMQEQ--EEKMWEQEEKMQEQEEKMWEQEE-----KMWEQEEKMWEQQR 659
+MQ E + E+EEK + ++E+ +E EE K +++ + ++
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDWRDAEEN 183
Query: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
E KEK E E+ ++ + E + ++ +EK + +E + ++ EE +E E
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
++ +E EKM+E++++ E E E EE+ + K + +++ +++ ++
Sbjct: 244 REQGSDEI---SHHEKMEEEDKERAEAERARLEAEER---ERIKAEQDKKIADERARIEA 297
Query: 780 HEKMQEQEKIW-EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
EK QE+ E EE+ R +EE+ R EE+ R +EE+ R EE+ +EE+ EE+
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ--EEKMREQEEKMRGQ--EEKI 891
+EE+ EE+ + + +EEK + +E+K Q E+K QE K++G+ E+KI
Sbjct: 358 RIKEEEKRAAEERQRARAE-EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413
Score = 113 bits (283), Expect = 7e-25
Identities = 130/575 (22%), Positives = 264/575 (45%), Gaps = 89/575 (15%)
Query: 71 DTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFED 130
DT +N KEEK S Q R EIE + + + QK + A ++ K E+
Sbjct: 140 DTAENETTEKEEKSESRQE----RYEIEETETVTK--SYQKNDWRDAEENKKEDKEKEEE 193
Query: 131 -------GNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQR 183
G++G + + + + S V SL G+ + E ++
Sbjct: 194 EEEKPKRGSIG-ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE------EREQ 246
Query: 184 ALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSE 243
+S K +EE KER E R + EE ++ AE +K+ E++
Sbjct: 247 GSDEISHHEK-----MEEEDKER----AEAERARLEAEERERIKAEQDKKI---ADERAR 294
Query: 244 IQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR 303
I+ K ++ ER + + E +RE+EK+ ++ +++ +E+R
Sbjct: 295 IEAEEKAAAQERERREA---------------EERERMREEEKRAAEERQRIKEEEKRAA 339
Query: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE----LREQEEQMQEQEEKMWE 359
E+ +++E+E++ + +R++E+EK E+ + R ++E + EQ+ Q +E+K
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
QE K++ EK+ ++ E W EK+ +E + + +++ E+ +++ K E+++E +
Sbjct: 400 QETKIK--GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPT 457
Query: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
+++ E++++EK +++E K +E + +R+K E + E K EN
Sbjct: 458 FKK-EEIKDEKIKKDKEPK--------EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 508
Query: 480 MW---------EQEEKEWQQQ-----RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
+ + +E E Q RL E + + E E +E E+ +Q+E + EE
Sbjct: 509 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES-EEFEKLKQKQQEAALELEE 567
Query: 526 MWGQEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKMWDQEERMEKKTQEQEKKTWDQE 582
+ +KK + K+ E+E+Q +QEE K+R++E+K +EE ++ + EK+ E
Sbjct: 568 L---KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
Query: 583 EKMREEER------MREREKKMREEEEMMREQEEK 611
+ + ++++ + K+ E E + + +K
Sbjct: 625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 659
Score = 103 bits (258), Expect = 5e-22
Identities = 85/371 (22%), Positives = 179/371 (48%), Gaps = 48/371 (12%)
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE-- 624
M+ + +E + +EE E ER+ + EEE + QE+ + QE+E
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 625 KMWEQEE-----KMQEQE-------------------EKMWEQEEKMWEQEEKMWEQQR- 659
++ +Q E + ++E E++ +EE+ ++ ++ E+Q+
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 660 -----------LPEQK--EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW-D 705
LP ++ E+E +++EK + ++E+ +E E+ E T+ +K W D
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDWRD 179
Query: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
E+ ++E+ +E E++ + + + E + ++ +E+ + QEE + + E+
Sbjct: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR---DQEEKMRGQEEKMRGQEEKMRGQEE 822
+++ + +++ HEKM+E++K + E+ R ++ E+++ +++K E EE
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE 299
Query: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKM---EEKMQGQEEKMREQEEKMRGQEEKMRE 879
K QE + EE+ +EE+ EE+ EE+ + EE+ R +EE+ R EE+ R
Sbjct: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
Query: 880 QEEKMRGQEEK 890
+EE+ R EE+
Sbjct: 360 KEEEKRAAEER 370
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1877 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1994 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2528
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2529 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2573
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2574 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2045
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2098
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2144
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2145 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2262
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2498
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2499 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2542
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2543 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2601
Query: 765 WEQQR 769
EQ R
Sbjct: 2602 EEQHR 2606
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1793 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1850 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1903
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1904 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1955 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 2008
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2367
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2427 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2486 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2544 ERQRLVASMEEARRRQHE 2561
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1167
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1168 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1222 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1338 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1455
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1512
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1569
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1686
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1708
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1819
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2173
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2234 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2408 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2463 QQEAKLLQLKSEEMQTV 2479
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1632
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1633 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2106
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2165
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2224
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1075
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1076 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1135
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1374
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1730
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAEL 1757
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1349
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1350 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1407 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1579
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1700 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1754
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1755 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1799
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1860 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1960
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2015
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2016 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2135 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2549
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1881 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1998 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2532
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2533 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2577
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2578 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2049
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2102
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2148
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2149 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2266
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2502
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2503 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2546
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2547 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2605
Query: 765 WEQQR 769
EQ R
Sbjct: 2606 EEQHR 2610
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1797 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1854 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1907
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1908 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1959 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 2012
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2312
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2371
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2372 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2431 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2490 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2548 ERQRLVASMEEARRRQHE 2565
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1113 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1171
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1172 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1226 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1342 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1459
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1516
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1573
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1690
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1810
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1712
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1823
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2177
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2238 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2412 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2467 QQEAKLLQLKSEEMQTV 2483
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1636
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1637 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2110
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2169
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2228
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1031 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1079
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1080 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1139
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1140 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1199
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1200 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1320 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1378
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1734
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAEL 1761
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1353
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1354 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1411 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1583
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1584 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1704 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1758
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1759 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1803
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1864 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1964
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2019
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2020 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2139 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2196
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2553
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1877 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1994 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2528
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2529 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2573
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2574 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2045
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2098
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2144
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2145 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2262
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2498
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2499 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2542
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2543 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2601
Query: 765 WEQQR 769
EQ R
Sbjct: 2602 EEQHR 2606
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1793 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1850 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1903
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1904 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1955 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 2008
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2367
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2427 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2486 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2544 ERQRLVASMEEARRRQHE 2561
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1167
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1168 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1222 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1338 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1455
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1512
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1569
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1686
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1708
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1819
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2173
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2234 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2408 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2463 QQEAKLLQLKSEEMQTV 2479
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1632
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1633 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2106
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2165
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2224
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1075
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1076 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1135
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1374
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1730
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAEL 1757
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1349
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1350 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1407 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1579
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1700 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1754
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1755 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1799
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1860 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1960
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2015
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2016 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2135 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2549
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1845 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1962 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2496
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2497 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2541
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2542 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2013
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2066
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2112
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2113 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2230
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2466
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2467 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2510
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2511 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2569
Query: 765 WEQQR 769
EQ R
Sbjct: 2570 EEQHR 2574
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1761 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1818 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1871
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1872 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1923 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 1976
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2276
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2335
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2336 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2395 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2454 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2512 ERQRLVASMEEARRRQHE 2529
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1077 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1135
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1136 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1190 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1245
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1246 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1306 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1423
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1480
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1537
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1654
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1774
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1676
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1787
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2141
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2202 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2375
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2376 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2431 QQEAKLLQLKSEEMQTV 2447
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1600
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1601 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2074
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2133
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2192
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 995 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1043
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1044 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1103
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1104 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1163
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1164 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1284 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1342
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1698
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAEL 1725
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1317
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1318 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1375 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1547
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1548 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1607
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1668 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1722
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1723 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1767
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1828 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1928
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 1983
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 1984 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2103 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2160
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2517
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 2014 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 2131 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2665
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2666 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2710
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2711 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2182
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2235
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2281
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2282 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2399
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2635
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2636 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2679
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2680 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2738
Query: 765 WEQQR 769
EQ R
Sbjct: 2739 EEQHR 2743
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1930 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1987 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 2040
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 2041 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 2092 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 2145
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2445
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2504
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2505 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2564 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2623 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2681 ERQRLVASMEEARRRQHE 2698
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1246 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1304
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1305 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1359 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1414
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1415 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1475 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1592
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1649
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1706
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1823
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1943
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1845
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1956
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2310
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2371 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2545 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2600 QQEAKLLQLKSEEMQTV 2616
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1769
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1770 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2243
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2302
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2361
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1164 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1212
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1213 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1272
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1273 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1332
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1333 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1453 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1511
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1867
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAEL 1894
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1486
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1487 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1544 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1716
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1717 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1837 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1891
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1892 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1936
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1997 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 2097
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2152
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2153 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2272 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2329
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2686
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1855 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1972 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2506
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2507 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2551
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2552 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2023
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2076
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2122
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2123 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2240
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2476
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2477 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2520
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2521 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2579
Query: 765 WEQQR 769
EQ R
Sbjct: 2580 EEQHR 2584
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1771 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1828 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1881
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1882 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1933 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 1986
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2286
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2287 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2345
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2346 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2405 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2464 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2522 ERQRLVASMEEARRRQHE 2539
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1087 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1145
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1146 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1200 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1255
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1256 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1316 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1433
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1490
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1547
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1664
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1784
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1686
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1797
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2151
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2212 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2385
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2386 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2440
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2441 QQEAKLLQLKSEEMQTV 2457
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1610
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1611 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2084
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2143
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2202
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2440
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1005 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1053
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1054 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1113
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1114 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1173
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1174 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1234 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1294 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1352
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1708
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAEL 1735
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1327
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1328 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1385 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1557
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1558 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1617
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1678 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1732
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1733 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1777
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1838 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1938
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 1993
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 1994 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2113 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2170
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2527
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1863 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1919
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 1980 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2514
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2515 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2559
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2560 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 1999 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2031
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2084
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2130
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2131 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2248
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2484
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2485 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2528
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2529 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2587
Query: 765 WEQQR 769
EQ R
Sbjct: 2588 EEQHR 2592
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1779 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1836 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1889
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1890 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1941 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 1994
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2234
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2294
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2295 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2353
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2354 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2413 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2472 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2530 ERQRLVASMEEARRRQHE 2547
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1095 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1153
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1154 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1208 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1263
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1264 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1324 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1382
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1441
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1498
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1555
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1672
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1792
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1694
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1805
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2159
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2220 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2393
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2394 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2448
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2449 QQEAKLLQLKSEEMQTV 2465
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1618
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1619 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2092
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2151
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2210
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2448
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1013 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1061
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1062 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1121
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1122 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1181
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1182 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1241
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1242 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1302 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1360
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1716
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAEL 1743
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1288
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1335
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1336 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1393 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1565
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1566 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1625
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1686 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1740
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1741 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1785
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1846 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1946
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2001
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2002 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2121 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2178
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2535
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 174 bits (440), Expect = 4e-43
Identities = 179/765 (23%), Positives = 371/765 (48%), Gaps = 81/765 (10%)
Query: 182 QRALSAVSTRHKKADRYIEE-LTKERDALSLELYRNTITNEELKKKNAELQEKL------ 234
+R L + +HK AD IEE L + R A EL R E+ ++ +++E++
Sbjct: 1904 RRRLEEQAAQHK-AD--IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1960
Query: 235 -PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
A + K+E++L + ++ E Q + ++ EEE R +E + R Q+
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEE 348
+ +EE R+++ + E E + E+ R +E+ +E ++L+ QK L+ +E+
Sbjct: 2021 -LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 349 ------QMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Q +EQE ++ +QE+ + +Q R E+ ++ R Q ++ Q R E
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 402 QDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
+ ERL++ EE+ + + + EK+R+E + + + +Q Q++ E EK +
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEK 519
E+T+R++ + Q+ + EE + Q+ L E+ ++L E + Q ++ E+
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 520 IRDQEEMWGQEKKMWRQEK----MREQEDQ---MWEQEEKMRDQEQKMW------DQEER 566
+R Q E + K E +R++++ + E+ EKM+ ++ + R
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 567 MEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMQEQEEK 625
+ + +E + EKM +E+ +E +++ E E++++Q+E QEQ ++QE +E+
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE--KMQEQE 683
M +Q + + ++ E E + Q E E +RL + ++ + E++ + ++Q
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQ--RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2437
Query: 684 EKIWEQ-EKMEKKTQEQ-----------EKKTWDQEKMREEESMREREK-KMREEEEMMR 730
E+I E+ + E TQE+ ++ D E++RE + EREK K+++E ++++
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497
Query: 731 EQEEKMQ--EQEEKMQEQE--EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
+ E+MQ +QE+ +QE + ++ + E+ Q E+ EQ++ + E+L++ E + Q
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA--KLEQLFQDEVAKAQ 2555
Query: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
+ EQ+ + + E++ ++ + EE R Q E G K QEE
Sbjct: 2556 QLREEQQRQQQQMEQE---RQRLVASMEEARRRQHEAEEGVRRK---QEEL--------- 2600
Query: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
+++E++ + QEE + E+ +++R Q + + EQ E++
Sbjct: 2601 ---QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Score = 149 bits (376), Expect = 1e-35
Identities = 148/725 (20%), Positives = 331/725 (45%), Gaps = 82/725 (11%)
Query: 56 TNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELE 115
+N E T + + + R EE++ + +E +++ + A++ R E+E
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 116 TALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSW 175
++A R E + LA A +
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQK--------------------------- 2072
Query: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLP 235
E + AV + ++ + +++ D L E E ++ E +E
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-------EAARRAAEEAEEARV 2125
Query: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
AE E ++ + V+E +R + A EE + + + +K+RK+ E+
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSA-------------EEQAQARAQAQAAAEKLRKEAEQ- 2171
Query: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
R + ++ +R+++ EK + E+ LR++ + +E LR Q E+ Q+
Sbjct: 2172 -EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
Query: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER---LREKEER 412
+ E+ ++++ + + RQ ++ E+ +R Q +++ + R+ E + R LR+K+
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-EAENRALILRDKDNT 2289
Query: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER---EKKMREEEETMREQ 469
R ++ E+++++ EE + + ++ EE+ ++R EK ++E+ + ++E
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 470 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 529
+ E ++E + Q +RL E KE++ +Q + Q + + E+ R E
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKM 585
E+ R +M + + E ++ R Q +++ ++ R E TQE+ + +++
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQEEKMQEQEEKMWEQE 644
+ ER+RE ++ E+E ++++ + +Q + E+MQ Q+E++ ++ + +Q+ + E
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS----FLSE 2525
Query: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
+ Q E+ EQ++ + E+L++ E + Q+ +EQ+ +Q++ME
Sbjct: 2526 KDSLLQRERFIEQEK--AKLEQLFQDEVAKAQQLREEQQR---QQQQME----------- 2569
Query: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
QE+ R SM E ++ E EE +R ++E++Q+ E++ ++QEE + E+ +++ EQ + +
Sbjct: 2570 -QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2628
Query: 765 WEQQR 769
EQ R
Sbjct: 2629 EEQHR 2633
Score = 144 bits (362), Expect = 5e-34
Identities = 177/858 (20%), Positives = 384/858 (44%), Gaps = 70/858 (8%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
++ A+L+ E A+ Q ++ L E+ + +L K E + + +++ +
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
G F +A R L + +D A + + E A+ +
Sbjct: 1820 AGR---FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+A+ ++E E + L R +E +++ E Q A+ E+ QL K
Sbjct: 1877 TEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR-KASD 1930
Query: 253 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312
+LER K L+ E+ RQ ++ E+ ++ EK + L + G++R
Sbjct: 1931 SELERQKGLV---------EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
E R +++ + + R+++ E++ RE EE++Q K EE+ Q +
Sbjct: 1982 AEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAAL 2035
Query: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
+ ERL + ++ R ++ + R + + +K + E+ + +K +E ++
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 433 QEQEKKTRDQ-----EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
+QE+ DQ E + E E + E R Q E+ ++ +++ EQ +
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155
Query: 488 WQQQRLPEQKEKLWEQE---KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Q Q E+ K EQE + Q ++ + +++ + E+ ++ RQ+ EQE
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
Query: 545 QMWEQEEKMRDQEQKMWDQE-ERMEKK-TQEQEKKTWDQEEKMREEERMREREK-KMREE 601
+ + D ++ + D+E +R++ + T+ +++ +EE +M E K K R E
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275
Query: 602 EE----MMREQEEK---MQEQEEKMQEQEEKMWEQEEKMQEQ-------EEKMWEQ---- 643
E ++R+++ +QE+ EKM++ E+ QE EE + +Q
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2335
Query: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
E+ + E+ + + E RL + E L + +++ +++ + QE+K +++ ++TQ ++ T
Sbjct: 2336 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR-T 2394
Query: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM-WEQEE 762
+ E+ R+ E E E+ EM R Q + +E ++ ++Q EE+ E+ + +E
Sbjct: 2395 LEAERQRQLEMSAEAERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQE 2453
Query: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKMRGQEEKMRGQEEKMRG 819
K+ Q L Q+++ +H+ + +E I E E EK++ + + ++ + E+M+ +++
Sbjct: 2454 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512
Query: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE-------KMQGQEEKMREQEEKMRG 872
QE + ++ +++ + +E + ++ K+E+ K Q E+ + Q+++M
Sbjct: 2513 QETQ--ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 873 QEEKM-REQEEKMRGQEE 889
+ +++ EE R Q E
Sbjct: 2571 ERQRLVASMEEARRRQHE 2588
Score = 142 bits (359), Expect = 1e-33
Identities = 165/757 (21%), Positives = 329/757 (43%), Gaps = 83/757 (10%)
Query: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
EE KE A+ L T LKK A+ + + P ++ + E++ +E+ +L++
Sbjct: 1136 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRH 1194
Query: 260 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-- 316
++ E WR+ +L E+ + + Q + R+ E+L Q RE + +
Sbjct: 1195 ------GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---------- 366
W Q+ R R+++ Q L + + +REQ Q Q E++ EK+ E
Sbjct: 1249 WLQDARRRQEQI----QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304
Query: 367 -----------------------QEEKMWRQEERLWEQEKQMR----------EQEQKMR 393
++ K+ E + ++ +R Q K
Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
+ R E++ERL E ++R E+E++ E + +++++ E + + Q E+ +E + R
Sbjct: 1365 SETLRRMEEEERLAE-QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1423
Query: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
+E+ +R EE + Q++K QEE ++ E + Q Q E E+ +++ +EE
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-ERSRLRIEEEIR 1482
Query: 514 WEQEEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
+ + + + G E ++ R E+ Q+ Q E+ E++R Q Q D+ +R +
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQ 1539
Query: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
E + + E RE++R + +++R + E E E ++++ E + Q + E
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAE---EAERRLRQAEVERARQVQVALET 1596
Query: 630 EEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
++ E E K EK + E + E+ Q + E Q+ E + +EE
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Query: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
E E+ + K E + E++ +++S+ + E + ++EE E+E + + + E+ ++
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE---AEREARRRGKAEEQAVRQ 1713
Query: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKE--KLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
E+ EQE + Q + QQRL ++E +L + EQ++ +EE R Q E
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 806 QEEKMRGQEE--KMRGQEE-----KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
+++ + E K+R + E K +EE E+ E + E EE +
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1833
Query: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVG 895
+ + ++ +E+ R++ E R EK+ +G
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Score = 137 bits (345), Expect = 4e-32
Identities = 165/857 (19%), Positives = 389/857 (45%), Gaps = 66/857 (7%)
Query: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Q++ AQ + EK+ +EA RR +A++ +R + ELE ++ A++
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQ----R 1735
Query: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRA------LS 186
L ++ +G + + ++ A EL + L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795
Query: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
A R ++ R E +K+R +R EL ++ A L+ LAE K + QL
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFR------ELAEEAARLRA---LAEEAKRQRQL 1846
Query: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK-----KIRKQEEKMWRQEER 301
++ R+ A+ +L + + + E E+ +EK ++R+ E Q R
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWE 359
L EQ + + E+ Q ++ + E E ++ E LR+++++ E+ ++ EK
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966
Query: 360 QEEKM-------REQEEKMWRQEERLWEQEKQMR----EQEQKMRDQEERMWE----QDE 404
+ ++ R E R +E+ + + R E+E++ R+ EER+ + ++E
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
R+++ + E E++ +VE+ R ++ EQE + Q + ++R++ EK +
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086
Query: 465 TMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
++ ++ +QE+++ +Q E E ++ E +E + E+ Q + E+ E+++
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146
Query: 523 QEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
E Q + + EK+R++ EQE R Q ++ ++++ E+ KK
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2200
Query: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
E+ +R++ ++ + +R + E Q+ + E+ ++++ + + Q +++E+ +
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Q E++ + + R+ + L +K Q +QE+ EK+ + + +
Sbjct: 2261 RVQMEELSKLKA------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 701 KKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
++ ++ EE+ ++R +KM +E+ ++ +++ + E +Q+Q+E EQ ++
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2374
Query: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
E +E+M +Q Q + + Q Q ++ + E+++ + +M + + ++ R
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2434
Query: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-EKMREQEEKMRGQEEKM 877
Q E++ EK+ ++ QE+ Q +++ + + E++RE ++ ++EK+
Sbjct: 2435 KQAEEI---GEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2489
Query: 878 REQEEKMRGQEEKIYCV 894
+++ + ++ + E++ V
Sbjct: 2490 QQEAKLLQLKSEEMQTV 2506
Score = 135 bits (341), Expect = 1e-31
Identities = 172/898 (19%), Positives = 392/898 (43%), Gaps = 98/898 (10%)
Query: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
E T Q L+EE A Q +E R + Q+ E E A ++A R+ E
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQ-----------QQAEAERA---REEAERELE 1659
Query: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
L + L L QA + ++ + + ++ + R
Sbjct: 1660 RWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEE-------LKKKNAELQEKLPLAESEKS 242
+K + E ++R A EL R E+ L+++ A LQ + A ++
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 243 EIQLNVKELKRKLE---RAKFLLPQVQTNTLQEEMWRQE------EELREQEKKIRKQEE 293
E++ + +++ ++E +K + +T ++ R E EL E+ ++R E
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 294 KMWRQEERLREQEGKMREQEEKMWRQE-------KRLR-EQEKELREQEKELREQKELRE 345
+ RQ + E + R + E++ ++ RL+ E E L+E+E E + L E
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 346 Q--------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE----QEKQMREQEQKMR 393
EEQ + + + E+ ++R+ + +++ L E Q +Q+ E+ ++
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958
Query: 394 DQEERMWEQDERLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
E+ L + R+R + K ++E R+ + E+E++ R+ EE++Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018
Query: 448 -----EEERIREREKKMREEE------ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
EEE R+R+ + E E E R E+ +++ + ++ Q++ E+
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Query: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
K + ++ +++ ++ +QE+ + DQ + G+ + + E+ ++ Q E+ Q
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQ--LRGEAE---AARRAAEEAEEARVQAEREAAQ 2133
Query: 557 EQKMWDQEERMEKKTQEQEKKTWDQE---EKMREEERMREREKKMREEEEMMREQEEKMQ 613
++ ++ ER+++ +EQ + + EK+R+E +E ++ + E+ +R+++
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADA 2192
Query: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
E E+ + E+ + ++ + QE + EE ++ E QRL + + ++
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA-ARQRS 2251
Query: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Q +E++ ++ E K++ + + + + ++K + ++E +KM++ E
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311
Query: 734 EKMQEQEEKMQEQEEEMWEQ----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 787
QE Q EE++ +Q E+ + E+ + + E RL + E L + +++ +++
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 788 KIWEQEEKMRDQ-EEKMRGQEEKMRGQEEK---MRGQEEKMWGQEEKMWGQEEKMWGQEE 843
++ E +E+M Q E+ +G + + + ++ M + E++ + +M + + +
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431
Query: 844 KMWGQEEKMEEKMQGQEEKMRE----------QEEKMRGQEEKMREQEEKMRGQEEKI 891
+ Q E++ EK+ E +E Q ++ E++RE ++ ++EK+
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2489
Score = 133 bits (335), Expect = 6e-31
Identities = 152/747 (20%), Positives = 338/747 (45%), Gaps = 71/747 (9%)
Query: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
+KA +E L K LS E +K L E P A + +SE++L + +L+
Sbjct: 1054 QKAQAEVEGLGKGVARLSAEA-----------EKVLALPEPSPAAPTLRSELELTLGKLE 1102
Query: 253 RKLERAKFLLPQVQTNTL--------QEEMWRQEEELREQE----------------KKI 288
+ + L +++T +L +E + EE+L+E + KK+
Sbjct: 1103 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1162
Query: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQE-------KRLREQEKELREQEKELREQK 341
R Q E + LR++ +E E++ ++ +R RE+ +L E+ + + Q
Sbjct: 1163 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1222
Query: 342 ELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
++R++E EQ+ Q E + + + R++E++ + ++ QE+ +
Sbjct: 1223 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1282
Query: 401 EQDERLREKEERMREQEKMWEQVEKMREEK----KMQEQEKKTRDQEEKMQE-EERIRER 455
E+ ER EK E + K + K E + K Q + + ++ K+Q E + +
Sbjct: 1283 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342
Query: 456 EKKMR---EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
+R E T+ Q K + E+EE+ +QQR E++E+L E E E++ +
Sbjct: 1343 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQ 1401
Query: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
+ E + + Q E +E + QE++ +E+ + +++ R ++++ + E + Q
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461
Query: 573 EQEKKTWDQE-EKMREEERMR---------EREKKMREEE-EMMREQEEKMQEQEEKMQE 621
+ ++ E ++R EE +R ER++ E E + +R + E+ + Q+ + QE
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 622 QEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
+ E++ Q +++ Q + + E ++ + E E+QR + E+L + E+ Q
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
+ E+ + + + Q + ++ E + E+ ++EE + + E+ + +
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
++ E E E E ++ + K E RL Q E++ + + + + E ++EE R+
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 801 EKMRGQEEKMRGQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
+ + +E+ +R + E+++ Q + G ++ E+++ ++ + E+ E++ Q
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL----IRLRAETEQGEQQRQ 1757
Query: 858 GQEEKMREQEEKMRGQEEKMREQEEKM 884
EE++ + + +K +E E ++
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAEL 1784
Score = 130 bits (328), Expect = 4e-30
Identities = 148/712 (20%), Positives = 323/712 (45%), Gaps = 60/712 (8%)
Query: 187 AVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEELKKKNAELQEKLPLAESEK 241
AV + ++ +EE+ + + + + Y N I + EL+ + Q + + ++K
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
Query: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
++Q + + ++ + ++ T T Q + E +R+ EE EER
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET--------LRRMEE-----EER 1376
Query: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
L EQ+ R +E + + + E++++L E + + Q E +E Q + QEE + +E
Sbjct: 1377 LAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMW 420
+ Q++K QEE +Q+R+ + + R E ER R + EE +R
Sbjct: 1434 AAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEEN 479
E E+ R + + Q + R +E + Q+ + E E+ R+ ++E+ R+++ +++
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1548
Query: 480 MWEQE---EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
E E EK+ Q L E + + E E+ Q E E+ +++ E + + Q
Sbjct: 1549 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV--ERARQVQVALETAQRSAEAELQ 1606
Query: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
K ++ + E ++++ + E E++ Q+Q + +EE RE ER + +
Sbjct: 1607 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1666
Query: 597 ---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
++R + E + +Q+ Q + EK +E+ E+ + K +EQ + E E+ E++ +
Sbjct: 1667 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 654 MWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
+ E QQRL ++E + +++ + + EQ+ ++ E+E + + +E T ++++
Sbjct: 1727 LAEGTAQQRLAAEQELI----RLRAETEQGEQQRQLLEEE-LARLQREAAAATQKRQELE 1781
Query: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
E + K+R E E++ + + +E+ E+ ++ E E + + L
Sbjct: 1782 AELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE---------L 1826
Query: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
E+ +L + ++++ +E+ R + E R EK+ E R + E +EK
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
+ E++ E Q ++EE+ + + E+ ++R + E+++
Sbjct: 1887 E-AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937
Score = 124 bits (311), Expect = 4e-28
Identities = 153/715 (21%), Positives = 325/715 (45%), Gaps = 123/715 (17%)
Query: 70 EDTQQNRAQLKEE---KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR 126
EDT + R Q++EE KAS + A + E+E + IR ++D R
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS-------------NAEDTLR 1987
Query: 127 KFEDGNLGTPSSFNLALSQAFRGSPLG-CVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185
E L LA + R V SL E A R + E++R
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE---AARQRKA--ALEEVERLK 2042
Query: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEE------LKKKNAELQEKLPLAES 239
+ V + +R +E ++ L+ E + + EE +++K ELQ+ L +S
Sbjct: 2043 AKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ-----EEMWRQEEELREQEK-------- 286
+++ + +R E A+ Q + Q EE R ++ EQ +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Query: 287 --KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
K+RK+ E+ R + ++ +R+++ EK + E+ LR++ + +E LR
Sbjct: 2162 AEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2219
Query: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Q E+ Q+ + E+ ++++ + + RQ ++ E+ +R Q +++ + R+ ++
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279
Query: 405 RL--REKEERMR----EQEKMWEQVEK----------------MREEKKMQEQ---EKKT 439
L R+K+ R E EKM + E+ + EE Q++ EK
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339
Query: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQK 497
+++ + +QE R++ + +++++E +EQ ++Q+ +E M +Q EE + Q+ L ++
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 498 EKLWE------------------QEKMQEQEEKIWEQEEKIRDQ---EEMWGQEK----- 531
++ E Q + +E ++ +Q E+I ++ E+ QEK
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 532 --KMWRQ------EKMREQEDQMWEQEEKMRDQ--------EQKMWDQEERMEKKTQEQE 575
++ RQ E++RE ++ ++EK++ + E+ Q+E++ ++TQ +
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 576 KKTWDQEEKMREEERMREREKKMREE---EEMMREQE--EKMQEQEEKMQEQEEKMWEQE 630
+ +++ + + ER E+EK E+ +E+ + Q+ E+ Q Q+++M+++ +++
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---V 2576
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
M+E + E EE + ++E++ + ++ Q+E+L E + +E++Q EE+
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 170 bits (431), Expect = 5e-42
Identities = 97/425 (22%), Positives = 234/425 (55%), Gaps = 20/425 (4%)
Query: 318 RQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER 377
R ++ RE+ +E R+ E+E ++E R ++++ ++++ E+ R++E++ RQ +R
Sbjct: 56 RNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR----HRERQRDREKERERQTDR 111
Query: 378 LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEK 437
E+++Q ++ + +++E + ER R+++ + + + EK RE + +E+++
Sbjct: 112 --ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 497
+T E+ +++ER RE+ ++ R E E RE+E K + + + E+E + + E+K
Sbjct: 170 QT----ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225
Query: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
+ ++ ++++ K + EK ++E E++ R ++ + D+ +++ + +++E
Sbjct: 226 R---QTDRERDRQRKTEREREKQAERER--ASERETERDKERERERDRDRDRDRRQKERE 280
Query: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
+ Q +R ++ E++++T + E+ RE ER RER +K E E RE+E + + + +
Sbjct: 281 R----QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336
Query: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
+ +E+E K Q E +E+ + + + E+E + E++R + + E E+ ++++
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERER-ERERDRQSAREREERERDRDRD 395
Query: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
+ +E+E + + +++T++Q ++ D+E R E REREK+ E + R+ + +
Sbjct: 396 RQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Query: 738 EQEEK 742
Q ++
Sbjct: 456 RQRKR 460
Score = 168 bits (425), Expect = 2e-41
Identities = 111/415 (26%), Positives = 231/415 (55%), Gaps = 18/415 (4%)
Query: 279 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
E R++E++ R+++ + R+ +R RE+ + +++ K R +R R++EKE RE++ + R
Sbjct: 55 ERNRQKERERRREKRQTERETDRKRERR-REKDRHRKRDRHRERQRDREKE-RERQTD-R 111
Query: 339 EQKELREQEEQMQEQEEKMWEQE-EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
E+ RE+E Q++ E+ E+E E+ R+++ R+ ER + EK+ Q + R ++
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT 171
Query: 398 RMWEQDERLREKE-----ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Q ER REK ER R++EK + ++ E + +E+E++T + E+ ++ +R
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 453 REREKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLPEQKEKLWEQE-KMQEQE 510
R+R++K E E E+E +++ E E+E E++ + R QKE+ + + K Q +
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 511 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKK 570
E+ E E K Q E + ++ ++E+ RE+E + Q E RD+E++ + +R +
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM 351
Query: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE 630
+E+ ++T + + E ER RERE+ + + RE+EE+ ++++ Q++ E+ E++
Sbjct: 352 DRERNRQTGREGRRQAERERERERER----DRQSAREREERERDRDRDRQKERERQTEKD 407
Query: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Q + EK E+E+ ++E + ++ +K+K E ++ ++ ++ ++ K
Sbjct: 408 RDGQRETEKQREREK---DRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 166 bits (419), Expect = 1e-40
Identities = 122/457 (26%), Positives = 250/457 (54%), Gaps = 34/457 (7%)
Query: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQE-GKMREQEEKMWRQEK 321
P Q + + + + ++ +++ +Q+E+ R+E+R E+E + RE+ + R K
Sbjct: 31 PGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRK 90
Query: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE-EKMREQEEKMWRQEERLWE 380
R R +E++ R++EKE RE++ RE++ Q +++ + E+E E RE E RQ + E
Sbjct: 91 RDRHRERQ-RDREKE-RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRE 148
Query: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
+E+Q ++++ R + Q ER R+KE RE+EK ++ RE ++ +E+E KT
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKE---REREK---NRQERRERERQREKENKTE 202
Query: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLPEQKEK 499
D+ ER RERE++ E ET R+++ ++ + E+E EK+ +++R E++
Sbjct: 203 DRHS-----ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERET- 256
Query: 500 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
E++K +E+E ++ + + E K+ R E+ RE E + Q E+ R++E+
Sbjct: 257 --ERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERN 314
Query: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
+ ER ++ +E++++T E +R +ERE+K + + EM RE+ + + +
Sbjct: 315 RKRERERERERERERQRET--------ERDREKERERKRKRQTEMDRERNRQTGREGRRQ 366
Query: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
E+E E+E + Q + E+ E+ +++ + +++ + ++ E EK +E+EK
Sbjct: 367 AERER---ERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKD 423
Query: 680 QEQE---EKIWEQEKMEKKTQEQEKKTWDQEKMREEE 713
+E E E+ E+EK + + +++E++T D++ R+ +
Sbjct: 424 RESERGRERGREREKQKGRERDRERQT-DRQAGRQRK 459
Score = 164 bits (414), Expect = 4e-40
Identities = 105/440 (23%), Positives = 232/440 (52%), Gaps = 28/440 (6%)
Query: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Q K D ++R ER R+KE R +++ E+ + E++ ++ + RD+ + Q
Sbjct: 44 QAHKDADGDDR-----ERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQ 98
Query: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
+ R +ERE++ E + RE+E QK+ E E+E + + ++ Q+E+ E+++
Sbjct: 99 RD-REKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRER--ERQRDA 155
Query: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
E+E + E+ R E ++K RE+E E+ E+ R +E++ ++
Sbjct: 156 EKERERQTDRERQRQTER---------NRQKEREREKNRQERRERERQREKENKTEDRHS 206
Query: 568 EK-KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
E+ + +E+E++T + E+ R+ +R R+R++K E E E+E + + E+ +E+E +
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266
Query: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686
++ + Q+E+ + + K + E+ E +R ++E+ E E+ +E+ + +E+E +
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETER---KRERQRERERERERNRKRERERER 323
Query: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746
+ + +++T+ +K ++++ R+ E RER ++ E E+E + + + ++ +
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE---EKMRDQEEKM 803
E E E++ Q+E+ +++ + ++ E EK +E+EK E E E+ R++ EK
Sbjct: 384 EREERERDRDRDRQKER---ERQTEKDRDGQRETEKQREREKDRESERGRERGRER-EKQ 439
Query: 804 RGQEEKMRGQEEKMRGQEEK 823
+G+E Q ++ G++ K
Sbjct: 440 KGRERDRERQTDRQAGRQRK 459
Score = 159 bits (402), Expect = 1e-38
Identities = 116/490 (23%), Positives = 240/490 (48%), Gaps = 60/490 (12%)
Query: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
+R QE R + + + ++E Q++ E+ E+ + RE + K R+ E+ +
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREK--D 86
Query: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
+ ++ ++ RD+E+ Q +R R+ R RE+E+ Q E+ RE ++ E+ + +
Sbjct: 87 RHRKRDRHRERQRDREKERERQTDRERD---RQREKERN-RQKERERETEREGERGRDRQ 142
Query: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
++ +E +R E+E++ + + E R+ E QK+ E EK Q++R
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER-----EKNRQERR-------- 189
Query: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
+ E+ E+E K D+ G+E++ +E+ E E + Q ++ RD+++K
Sbjct: 190 --------ERERQREKENKTEDRHSERGRERE---RERETETETERKRQTDRERDRQRKT 238
Query: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
+ E+ ++ + E++T +E+ RE +R R+R+++ +E E R+ + K Q + E+ +
Sbjct: 239 EREREKQAERERASERETERDKERERERDRDRDRDRRQKERE---RQTDRKRQRRTERDR 295
Query: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
E E K Q E+ +E+E + E+ E+E E ++ E+++ +
Sbjct: 296 ETERKRERQRERERERERNRKRERERERERER----------------ERQRETERDREK 339
Query: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK-MREEEEMMREQEEKMQEQ 739
E+E K Q +M+++ Q + ++ RE E RER+++ RE EE R+++ Q++
Sbjct: 340 ERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKE 399
Query: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
E+ E++ + + EK E+E + +E E+ +E+EK +E Q
Sbjct: 400 RERQTEKDRDGQRETEKQRERE----------KDRESERGRERGREREKQKGRERDRERQ 449
Query: 800 EEKMRGQEEK 809
++ G++ K
Sbjct: 450 TDRQAGRQRK 459
Score = 155 bits (392), Expect = 2e-37
Identities = 113/472 (23%), Positives = 245/472 (51%), Gaps = 52/472 (11%)
Query: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
E R Q + D E+ +++ER R REK+ + E ET R++E + +K ++
Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKR-QTERETDRKRERRREKDRHRKRDR 93
Query: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
+ +Q+ +++E+ ++E+ +++E++ Q+E+ R+ E E+ R+++
Sbjct: 94 HRE--RQRDREKERERQTDRERDRQREKERNRQKERERETER---------EGERGRDRQ 142
Query: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
+ E+ RD E+ ER + +E++++T E+ R++ER RE+ ++ R E E
Sbjct: 143 TDGQRERERQRDAEK------ERERQTDRERQRQT----ERNRQKEREREKNRQERRERE 192
Query: 604 MMREQEEKMQEQ--EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
RE+E K +++ E + + E+ E E + + Q ++ +++ K + EK E++R
Sbjct: 193 RQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252
Query: 662 E---QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
E +++K E E+ +++++ + Q+E+ + ++ ++ E++++T ++++ R+ E RER
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET-ERKRERQRERERER 311
Query: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
E+ + E E RE+E + Q + E+ +E+E E + + ++E + Q E+
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER 371
Query: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
E E+ ++++ E+EE+ RD++ + + E+ Q EK R + + Q E+
Sbjct: 372 ERERERDRQSAREREERERDRDRDRQKERER---QTEKDRDGQRETEKQRER-------- 420
Query: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
EK E +G+E + RE+ EK +G+E Q ++ G++ K
Sbjct: 421 -----------EKDRESERGRE-RGRER-EKQKGRERDRERQTDRQAGRQRK 459
Score = 152 bits (385), Expect = 1e-36
Identities = 107/442 (24%), Positives = 234/442 (52%), Gaps = 28/442 (6%)
Query: 447 QEEERIR---EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
QE R R + K ++ Q+E+ +++E+ E+E +++R +K++ ++
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERR--REKDRHRKR 91
Query: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563
++ +E++ ++ E+ D+E +EK+ RQ +E+E + + E+ RD++ +
Sbjct: 92 DRHRERQRDREKERERQTDRERDRQREKERNRQ---KERERETEREGERGRDRQTDGQRE 148
Query: 564 EERMEKKTQEQEKKT----WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ--EE 617
ER +E+E++T Q E+ R++ER RE+ ++ R E E RE+E K +++ E
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSER 208
Query: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE---QKEKLWEHEKMQ 674
+ + E+ E E + + Q ++ +++ K + EK E++R E +++K E E+ +
Sbjct: 209 GRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDR 268
Query: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
++++ + Q+E+ + ++ ++ E++++T ++++ R+ E RERE+ + E E RE+E
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRET-ERKRERQRERERERERNRKRERERERERER 327
Query: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
+ Q + E+ +E+E E + + ++E + Q E+ E E+ ++++ E+EE
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Query: 795 KMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE 854
+ RD++ Q+E+ R E+ GQ E EK Q E+ +E + + + E
Sbjct: 388 RERDRDRDR--QKERERQTEKDRDGQRE-----TEK---QREREKDRESERGRERGRERE 437
Query: 855 KMQGQEEKMREQEEKMRGQEEK 876
K +G+E Q ++ G++ K
Sbjct: 438 KQKGRERDRERQTDRQAGRQRK 459
Score = 149 bits (376), Expect = 1e-35
Identities = 105/438 (23%), Positives = 228/438 (52%), Gaps = 30/438 (6%)
Query: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
HK AD E ++++ R T + K++ +++ + + + KE
Sbjct: 46 HKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKER 105
Query: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-QEGKMR 310
+R+ +R E RQ E+ R ++K+ ++ E R+ ER R+ Q R
Sbjct: 106 ERQTDR---------------ERDRQREKERNRQKERERETE---REGERGRDRQTDGQR 147
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
E+E + +++R R+ ++E + Q + R+++ RE+ Q + + E+ E+E K ++ +
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE-ERMREQEKMWEQVEKMREE 429
R+ ER E+E + + ++ D+E + ER REK+ ER R E+ E+ +K RE
Sbjct: 208 RGRERER--ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER-DKERER 264
Query: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
++ +++++ R +E + Q + + + R ++ RE E Q E+ +++E N + E+E +
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Query: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE-KKMWRQEKMREQE---DQ 545
++R ++++ E+++ +E+E K Q E R++ G+E ++ +E+ RE+E
Sbjct: 325 RER---ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381
Query: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
E+EE+ RD+++ + ER +K ++ +++T Q E+ ++ E R RE+ E++
Sbjct: 382 AREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Query: 606 REQEEKMQEQEEKMQEQE 623
RE++ + Q + ++++
Sbjct: 442 RERDRERQTDRQAGRQRK 459
Score = 141 bits (355), Expect = 3e-33
Identities = 111/406 (27%), Positives = 218/406 (53%), Gaps = 44/406 (10%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
RH+K DR+ E ++RD E R T+ E ++ E E++ + +E
Sbjct: 87 RHRKRDRHRE---RQRDR---EKERERQTDRERDRQR----------EKERNRQKERERE 130
Query: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMR 310
+R+ ER + QT+ Q E RQ + +E+E++ ++ + RQ ER R++E R
Sbjct: 131 TEREGERGR----DRQTDG-QRERERQRDAEKERERQTDRERQ---RQTERNRQKE---R 179
Query: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQE-EQMQEQEEKMWEQEEKMREQEE 369
E+E+ RQE+R RE+++E +E + E R + RE+E E+ E E + Q ++ R+++
Sbjct: 180 EREKN--RQERRERERQRE-KENKTEDRHSERGRERERERETETETERKRQTDRERDRQR 236
Query: 370 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
K R+ E+ E+E R E++ +ER E+D R R+++ R +E+E+ + R+
Sbjct: 237 KTEREREKQAERE---RASERETERDKERERERD-RDRDRDRRQKERERQTD-----RKR 287
Query: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
++ E++++T + E+ +E ER RER +K E E RE+E + + + + E+E K +
Sbjct: 288 QRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKR 347
Query: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Q + ++ + +E ++ E + E+ R+++ +E++ +++ R+++ + Q
Sbjct: 348 QTEMDRERNRQTGREGRRQAE----RERERERERDRQSAREREERERDRDRDRQKERERQ 403
Query: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
EK RD +++ Q ER + + E+ ++ + EK + ER RER+
Sbjct: 404 TEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQ 449
Score = 114 bits (286), Expect = 3e-25
Identities = 79/350 (22%), Positives = 173/350 (49%), Gaps = 11/350 (3%)
Query: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
+Q +W + D ++ +E ++ Q K D +++ R ++ RER ++ R+
Sbjct: 11 DQLGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQ 70
Query: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
E RE + K + + EK + ++ + ++ +E+E + E+ ++E++ Q+
Sbjct: 71 TE---RETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKER 127
Query: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
+ E+ E + ++ + +E+E + +++ E++T + ++ E+ R++E RE+ +
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR--QTERNRQKEREREKNR 185
Query: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
+ R E E RE+E K E++ E+ E + E E E K + Q++ E
Sbjct: 186 QERRERERQREKENK---TEDRHSERGRERERERETETETERKRQTDRERDRQRKTERER 242
Query: 781 EKMQEQEKIWEQE-EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMW 839
EK E+E+ E+E E+ +++E + ++ R Q+E+ R + K + E+ E K
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302
Query: 840 GQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Q E+ +E + K + + E+ RE+E + + ++ +E+E K + Q E
Sbjct: 303 RQRER--ERERERNRKRERERERERERERQRETERDREKERERKRKRQTE 350
Score = 112 bits (280), Expect = 2e-24
Identities = 90/354 (25%), Positives = 179/354 (50%), Gaps = 43/354 (12%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
E +R A R ++ DR + T+ RN E +K E +E+ E
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTE----------RNRQKEREREKNRQERRERERQREK 197
Query: 240 E-KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
E K+E + + + +R+ ER + +T T E RQ + R++++K ++ EK Q
Sbjct: 198 ENKTEDRHSERGRERERER------ETETET---ERKRQTDRERDRQRKTEREREK---Q 245
Query: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
ER R E RE E R+ +R R+++++ R++E+E + ++ + + E+ +E E K
Sbjct: 246 AERERASE---RETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302
Query: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Q E+ RE+E R+ ER E+E++ Q + RD+E+ + ER R+++ M +
Sbjct: 303 RQRERERERERNRKRERER--ERERERERQRETERDREK----ERERKRKRQTEMDRERN 356
Query: 419 MWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 478
E R+ ++ +E+E++ RD++ + EER R+R++ ++E E E++ Q++ E
Sbjct: 357 RQTGREGRRQAERERERERE-RDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETE 415
Query: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 532
E+E + +E +E+ +E+E++ + ++ R + G+++K
Sbjct: 416 KQRERE----------KDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 88.6 bits (218), Expect = 2e-17
Identities = 75/275 (27%), Positives = 144/275 (52%), Gaps = 22/275 (8%)
Query: 192 HKKADRYIE---ELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNV 248
+K DR+ E E +ER+ E R T+ E ++ +E+ AE E++ +
Sbjct: 199 NKTEDRHSERGRERERERET-ETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEG 307
++ +R+ ER + + Q+E RQ + R++ ++ R+ E K RQ ER RE+E
Sbjct: 258 RDKERERERDR----DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERER 313
Query: 308 -----KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE 362
+ RE+E + RQ + R++EK E+E++ + Q E+ + + +E + Q E
Sbjct: 314 NRKRERERERERERERQRETERDREK---ERERKRKRQTEMDRERNRQTGREGR--RQAE 368
Query: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
+ RE+E + RQ R E+E++ R++++ + + ER E+D + + E+ RE+EK E
Sbjct: 369 RERERERERDRQSAR--EREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRES 426
Query: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
E+ RE + +E++K E+ + + R+R++
Sbjct: 427 -ERGRERGREREKQKGRERDRERQTDRQAGRQRKR 460
Score = 48.1 bits (113), Expect = 4e-05
Identities = 46/194 (23%), Positives = 95/194 (48%), Gaps = 19/194 (9%)
Query: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
R ++ DR + T ERD E R E +++ +E+ E E+ + +E
Sbjct: 279 RERQTDRKRQRRT-ERDR-ETERKRERQRERERERERNRKRER----ERERERERERQRE 332
Query: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMR 310
+R E+ + + QT +E + E R Q ++ R++E + RQ R RE+ + R
Sbjct: 333 TERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDR 392
Query: 311 EQEEKMWRQEKRLREQEKEL-------REQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
+++ RQ++R R+ EK+ +++E+E + +E E+ +E+E++ + ++
Sbjct: 393 DRD----RQKERERQTEKDRDGQRETEKQRERE--KDRESERGRERGREREKQKGRERDR 446
Query: 364 MREQEEKMWRQEER 377
R+ + + RQ +R
Sbjct: 447 ERQTDRQAGRQRKR 460
Score = 44.3 bits (103), Expect = 5e-04
Identities = 40/194 (20%), Positives = 90/194 (46%), Gaps = 8/194 (4%)
Query: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
E +R R + DR E + + E RN E +++ +++ E+
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR----ET 333
Query: 240 EKSEIQLNVKELKRKLERAKFLLPQV-QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
E+ + ++ KR+ E + Q + Q E R+ E R+++ ++E + R
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRD 393
Query: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
+R +E+E + E++ R+ ++ RE+EK+ RE E+ RE+ RE+++ + E+
Sbjct: 394 RDRQKERE-RQTEKDRDGQRETEKQREREKD-RESERG-RERGREREKQKGRERDRERQT 450
Query: 359 EQEEKMREQEEKMW 372
+++ + + ++
Sbjct: 451 DRQAGRQRKRSTLY 464
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.120 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,881,270
Number of Sequences: 37866
Number of extensions: 2966671
Number of successful extensions: 327774
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1997
Number of HSP's successfully gapped in prelim test: 1204
Number of HSP's that attempted gapping in prelim test: 24241
Number of HSP's gapped (non-prelim): 69131
length of query: 899
length of database: 18,247,518
effective HSP length: 111
effective length of query: 788
effective length of database: 14,044,392
effective search space: 11066980896
effective search space used: 11066980896
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.