Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 119392083
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
(405 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 817 0.0
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 241 9e-64
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 162 4e-40
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 162 4e-40
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 162 4e-40
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 156 3e-38
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 155 5e-38
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 153 2e-37
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 153 2e-37
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 153 2e-37
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 153 2e-37
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 151 9e-37
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 139 5e-33
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 77 3e-14
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 75 8e-14
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 75 8e-14
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 68 1e-11
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 67 2e-11
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 60 4e-09
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 60 5e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 60 5e-09
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 60 5e-09
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 59 6e-09
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 58 2e-08
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 57 4e-08
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 55 9e-08
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 52 1e-06
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 51 2e-06
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 51 2e-06
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 50 4e-06
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 817 bits (2110), Expect = 0.0
Identities = 405/405 (100%), Positives = 405/405 (100%)
Query: 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV 60
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
Sbjct: 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV 60
Query: 61 LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG 120
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
Sbjct: 61 LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG 120
Query: 121 AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS 180
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
Sbjct: 121 AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS 180
Query: 181 PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA 240
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
Sbjct: 181 PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA 240
Query: 241 LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI 300
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
Sbjct: 241 LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI 300
Query: 301 EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR 360
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
Sbjct: 301 EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR 360
Query: 361 RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 405
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
Sbjct: 361 RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 405
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 241 bits (615), Expect = 9e-64
Identities = 147/373 (39%), Positives = 201/373 (53%), Gaps = 3/373 (0%)
Query: 8 SGGAWLLVAARALL--QLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAG 65
S AW+ +A +L + + L + + LA L +C +L P L + + +
Sbjct: 6 SDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSC 65
Query: 66 WIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELR 125
++ + L+ + LPV +AVL+TG D G G K LD +GFTV A VL N PGA ELR
Sbjct: 66 FLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELR 125
Query: 126 TCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATF 185
CSPRL +LQMD+TKP I A GLW ++NNAG D EL + +
Sbjct: 126 RTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDY 185
Query: 186 RSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDT 245
+ CM VNFFG +E+TK LPLLR S+GR+V V S G P L +YG+SKAAV +
Sbjct: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
Query: 246 FSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
EL WG+KV+ IQPG F T +WEK ++ +L +LP E+ + YG+DYI
Sbjct: 246 MRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRN 305
Query: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQA 365
L LA D +PV+ I A+LA P Y PG+G L + +YLP G+ F +
Sbjct: 306 FLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKR 365
Query: 366 FF-ISHCLPRALQ 377
F +PRAL+
Sbjct: 366 HFGQDKPMPRALR 378
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 162 bits (411), Expect = 4e-40
Identities = 97/275 (35%), Positives = 147/275 (53%), Gaps = 22/275 (8%)
Query: 79 PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVL--ELNSPGAIELRTCCSPRLRLLQ 136
PV ++AVL+TGCDSGFG AK L S GF V A L + G EL + S RLR +Q
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 137 MDLTKPGDISRVLEFTKAHTTST--GLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFF 194
+++ ++ +V+E ++ G+WGLVNNAG + + E + + T++ EVN +
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 195 GALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWG 254
G + +TK LPL+R ++GR+V + S G M P Y +K V D E+ P G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 255 VKVSIIQPGCF-------KTESVRNVGQ--WEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
VKVS+++PG F ES++ + + WE+ LP+ + + YGK Y +
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEE--------LPEVVRKDYGKKYFDEKIA 282
Query: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYP 340
+ +D +PV+DA+T AL A P RY+P
Sbjct: 283 KMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 162 bits (411), Expect = 4e-40
Identities = 97/275 (35%), Positives = 147/275 (53%), Gaps = 22/275 (8%)
Query: 79 PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVL--ELNSPGAIELRTCCSPRLRLLQ 136
PV ++AVL+TGCDSGFG AK L S GF V A L + G EL + S RLR +Q
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 137 MDLTKPGDISRVLEFTKAHTTST--GLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFF 194
+++ ++ +V+E ++ G+WGLVNNAG + + E + + T++ EVN +
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 195 GALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWG 254
G + +TK LPL+R ++GR+V + S G M P Y +K V D E+ P G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 255 VKVSIIQPGCF-------KTESVRNVGQ--WEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
VKVS+++PG F ES++ + + WE+ LP+ + + YGK Y +
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEE--------LPEVVRKDYGKKYFDEKIA 282
Query: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYP 340
+ +D +PV+DA+T AL A P RY+P
Sbjct: 283 KMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 162 bits (411), Expect = 4e-40
Identities = 97/275 (35%), Positives = 147/275 (53%), Gaps = 22/275 (8%)
Query: 79 PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVL--ELNSPGAIELRTCCSPRLRLLQ 136
PV ++AVL+TGCDSGFG AK L S GF V A L + G EL + S RLR +Q
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 137 MDLTKPGDISRVLEFTKAHTTST--GLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFF 194
+++ ++ +V+E ++ G+WGLVNNAG + + E + + T++ EVN +
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 195 GALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWG 254
G + +TK LPL+R ++GR+V + S G M P Y +K V D E+ P G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 255 VKVSIIQPGCF-------KTESVRNVGQ--WEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
VKVS+++PG F ES++ + + WE+ LP+ + + YGK Y +
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEE--------LPEVVRKDYGKKYFDEKIA 282
Query: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYP 340
+ +D +PV+DA+T AL A P RY+P
Sbjct: 283 KMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 156 bits (395), Expect = 3e-38
Identities = 97/274 (35%), Positives = 141/274 (51%), Gaps = 4/274 (1%)
Query: 85 VLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144
V ITGCDSGFG A++LD+ G VLA L GA +LR S RL + +D+TK
Sbjct: 32 VFITGCDSGFGNLLARQLDARGLRVLAACL--TEKGAEQLRGQTSDRLETVTLDVTKMES 89
Query: 145 ISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLL 204
I+ ++ K H GLWGLVNNAG + E + ++VN G +++T +L
Sbjct: 90 IAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSML 149
Query: 205 PLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGC 264
PL+R +RGRIV V S G + + +G Y SK V D E+ +GVK+SI++PG
Sbjct: 150 PLVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGY 208
Query: 265 FKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDA 324
F+T + N+ Q +R + P+ + + YG+ Y + L+ L ++L V D
Sbjct: 209 FRT-GMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDC 267
Query: 325 ITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGL 358
+ AL + PR RY G + YLP L
Sbjct: 268 MEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSL 301
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 155 bits (393), Expect = 5e-38
Identities = 104/300 (34%), Positives = 150/300 (50%), Gaps = 5/300 (1%)
Query: 60 VLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP 119
+L A W L L Q LP + V ITGCDSGFG+ A +LD GF VLA+ L
Sbjct: 6 LLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL--TPS 63
Query: 120 GAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAEL 179
GA +L+ S RL +D+T P + + ++ + H GL+GLVNNAG ++
Sbjct: 64 GAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPW 123
Query: 180 SPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAV 239
F+ + VN G + +T LLPLL+ +RGR++ + S G + G Y SK +
Sbjct: 124 LTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANG-GGYCVSKFGL 182
Query: 240 ALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDY 299
D+ ++ +G++VSI++PG F+T V N+ EK Q A LP YG +
Sbjct: 183 EAFSDSLRRDVAHFGIRVSIVEPGFFRT-PVTNLESLEKTLQACWARLPPATQAHYGGAF 241
Query: 300 I-EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGL 358
+ ++L Q + DLT V + AL A PR RY PG L++ YLP L
Sbjct: 242 LTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASL 301
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 153 bits (387), Expect = 2e-37
Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
+ + + ITGCDSGFG A+ D GF V+A L + A++ T S RLR + +D+
Sbjct: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
T P ++ R ++ K GLWGL+NNAG V+A + + +R +EVN FG + +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
T +LPL++ ++GR++ V S G + G Y SK AV D+ ++ +GV VS
Sbjct: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
Query: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
I+PG FKT V EK K + L ++ Q YG+ YIE + + DL+
Sbjct: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
Query: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359
PVV+ + AL + P+ Y G+ + + ++P L+
Sbjct: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 153 bits (387), Expect = 2e-37
Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
+ + + ITGCDSGFG A+ D GF V+A L + A++ T S RLR + +D+
Sbjct: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
T P ++ R ++ K GLWGL+NNAG V+A + + +R +EVN FG + +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
T +LPL++ ++GR++ V S G + G Y SK AV D+ ++ +GV VS
Sbjct: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
Query: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
I+PG FKT V EK K + L ++ Q YG+ YIE + + DL+
Sbjct: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
Query: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359
PVV+ + AL + P+ Y G+ + + ++P L+
Sbjct: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 153 bits (387), Expect = 2e-37
Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
+ + + ITGCDSGFG A+ D GF V+A L + A++ T S RLR + +D+
Sbjct: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
T P ++ R ++ K GLWGL+NNAG V+A + + +R +EVN FG + +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
T +LPL++ ++GR++ V S G + G Y SK AV D+ ++ +GV VS
Sbjct: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
Query: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
I+PG FKT V EK K + L ++ Q YG+ YIE + + DL+
Sbjct: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
Query: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359
PVV+ + AL + P+ Y G+ + + ++P L+
Sbjct: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 153 bits (387), Expect = 2e-37
Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
+ + + ITGCDSGFG A+ D GF V+A L + A++ T S RLR + +D+
Sbjct: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
T P ++ R ++ K GLWGL+NNAG V+A + + +R +EVN FG + +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
T +LPL++ ++GR++ V S G + G Y SK AV D+ ++ +GV VS
Sbjct: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
Query: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
I+PG FKT V EK K + L ++ Q YG+ YIE + + DL+
Sbjct: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
Query: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359
PVV+ + AL + P+ Y G+ + + ++P L+
Sbjct: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 151 bits (382), Expect = 9e-37
Identities = 99/271 (36%), Positives = 143/271 (52%), Gaps = 4/271 (1%)
Query: 85 VLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144
V ITGCDSGFGK A++LD+ G VLA L GA +LR S RL + +D+TK
Sbjct: 32 VFITGCDSGFGKLLARQLDARGLRVLAACL--TEKGAEQLRGQTSDRLETVTLDVTKTES 89
Query: 145 ISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLL 204
++ ++ K GLWGLVNNAG + A EL F + ++VN G +++T LL
Sbjct: 90 VAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLL 149
Query: 205 PLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGC 264
PL+R +RGR+V V S G + G Y SK V D+ EL +GVKV++I+PG
Sbjct: 150 PLVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGY 208
Query: 265 FKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDA 324
FKT +V + ++ K + E+ +AYG+ ++ + DL+ V +
Sbjct: 209 FKT-AVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSLVTNC 267
Query: 325 ITDALLAARPRRRYYPGQGLGLMYFIHYYLP 355
+ AL+A PR RY G L+Y Y+P
Sbjct: 268 MEHALIACHPRTRYSAGWDAKLLYLPMSYMP 298
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 139 bits (350), Expect = 5e-33
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 9/295 (3%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
++ + V ITGCDSGFG AK+L G VLA G+ +L+ S RL+ +D+
Sbjct: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACF--TEEGSQKLQRDTSYRLQTTLLDV 80
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
TK I ++ + GLW LVNNAG E F + VN G +E+
Sbjct: 81 TKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEV 140
Query: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
T +LP+++ +RGR+V + S G + G Y SK V D+ EL +GVKV I
Sbjct: 141 TLHMLPMVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGVKVCI 199
Query: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
I+PG ++T ++ E R + L LPQE +YG+DY + + +++A +
Sbjct: 200 IEPGNYRT-AILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVAEPRVR 258
Query: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPR 374
V++++ A+++ PR RY PG L+Y LP + F +S LPR
Sbjct: 259 DVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP-----VTDFILSRYLPR 308
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 77.0 bits (188), Expect = 3e-14
Identities = 76/271 (28%), Positives = 112/271 (41%), Gaps = 27/271 (9%)
Query: 80 VATRAVLITGCDSGFGKETAKKL---DSMGFTVLATVLELNSPG----AIELRTCCSPRL 132
+A VLITGC SG G A +L S F V AT+ +L + G A C L
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
Query: 133 RLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVN 192
LQ+D+ ++ E T + LV NAG ++ E S ++VN
Sbjct: 61 ETLQLDVRDSKSVAAARE----RVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVLDVN 115
Query: 193 FFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELL 251
G + + + LP + R GR++ GS G M P Y SK A+ L ++ + LL
Sbjct: 116 VVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLL 175
Query: 252 PWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHS- 310
P+GV +S+I+ G T + V P+E+L + HS
Sbjct: 176 PFGVHLSLIECGPVHTAFMEKV-----------LGSPEEVLDRTDIHTFHRFYQYLAHSK 224
Query: 311 --LRLAMSDLTPVVDAITDALLAARPRRRYY 339
R A + V + AL A +P RY+
Sbjct: 225 QVFREAAQNPEEVAEVFLTALRAPKPTLRYF 255
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 75.5 bits (184), Expect = 8e-14
Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 48/329 (14%)
Query: 37 ALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATR--AVLITGCDSGF 94
+L + A+D++ + P + G L RL + R R V+ITG SG
Sbjct: 9 SLPKVKAMDFITSTAILP----LLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGL 64
Query: 95 GKETAKKLDSMGFTVLAT----------VLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144
GKE AK + G ++ + EL + A +++T + L+ DLT G
Sbjct: 65 GKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQT---HKPYLVTFDLTDSGA 121
Query: 145 ISRVLEFTKAHTTSTGLWG----LVNNAG--HNEVVADAELSPVATFRSCMEVNFFGALE 198
I A +G LVNNAG + + D + V + ME N+FG +
Sbjct: 122 I------VAAAAEILQCFGYVDILVNNAGISYRGTIMD---TTVDVDKRVMETNYFGPVA 172
Query: 199 LTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKV 257
LTK LLP +++ +G IV + S G M P AY SK A D E+ + ++V
Sbjct: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEV 232
Query: 258 SIIQPGCFKTE-SVRNVGQWEKRKQLL---------LANLPQELLQAYGKDYIEHLHGQF 307
++I PG T SV + R ++ + Q++L A GK + +
Sbjct: 233 TVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADL 292
Query: 308 LHSLRLAMSDLTPVVDAITDALLAARPRR 336
L SL + + L P + +L+A+R R+
Sbjct: 293 LPSLAVYLRTLAP---GLFFSLMASRARK 318
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 75.5 bits (184), Expect = 8e-14
Identities = 57/197 (28%), Positives = 93/197 (47%), Gaps = 12/197 (6%)
Query: 78 LPVATRAVLITGCDSGFGKETAKKL---DSMGFTVLATVLELNSPGAIELRT--CCSPRL 132
+ A R VLI+GC SG G E A +L + V+AT+ +L +E L
Sbjct: 1 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL 60
Query: 133 RLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVN 192
+ Q+D+ +++ L + LVNNAG +V E +A ++ + N
Sbjct: 61 TVAQLDVCSDESVAQCLSCIQGEVDV-----LVNNAGMG-LVGPLEGLSLAAMQNVFDTN 114
Query: 193 FFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELL 251
FFGA+ L K +LP + R +G IV + S G Y SK A+ ++ + +LL
Sbjct: 115 FFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLL 174
Query: 252 PWGVKVSIIQPGCFKTE 268
+ + +S+++PG TE
Sbjct: 175 QFNIFISLVEPGPVVTE 191
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 68.2 bits (165), Expect = 1e-11
Identities = 49/183 (26%), Positives = 81/183 (44%), Gaps = 5/183 (2%)
Query: 81 ATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLT 140
A + V++TG G G + + G V+ + + A+E P + D+T
Sbjct: 8 AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL---PGAVFILCDVT 64
Query: 141 KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELT 200
+ D+ ++ T +VNNAGH+ E + FR +E+N G LT
Sbjct: 65 QEDDVKTLVSETIRRFGRLDC--VVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
Query: 201 KGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSII 260
K LP LR S+G ++ + S G + Y +K AV + + + P+GV+V+ I
Sbjct: 123 KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCI 182
Query: 261 QPG 263
PG
Sbjct: 183 SPG 185
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 67.4 bits (163), Expect = 2e-11
Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 15/244 (6%)
Query: 40 LLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLP---VATRAVLITGCDSGFGK 96
LL L LC LL L L A G + L R P + V +TG SG G+
Sbjct: 5 LLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGE 64
Query: 97 ETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLR-----LLQMDLTKPGDISRVLEF 151
E A +L +G +++ + ++ ++ R + L+ +L +DLT G
Sbjct: 65 ELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAA--- 121
Query: 152 TKAHTTSTG-LWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLP-LLRS 209
TKA G + LVNN G ++ + S + +R +E+N+ G + LTK +LP ++
Sbjct: 122 TKAVLQEFGRIDILVNNGGMSQRSLCMDTS-LDVYRKLIELNYLGTVSLTKCVLPHMIER 180
Query: 210 SRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPW-GVKVSIIQPGCFKTE 268
+G+IVTV S G + P Y SK A+ + EL + G+ VS I PG ++
Sbjct: 181 KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN 240
Query: 269 SVRN 272
V N
Sbjct: 241 IVEN 244
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 60.1 bits (144), Expect = 4e-09
Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 7/207 (3%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMG-FTVLATVLELNSPGAIELRTCCSPRLRLLQMD 138
+A R ++TG SG G A++L G V+++ + N A+ + +
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 139 LTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALE 198
+ K D +++ KA G+ LV +AG N +V + + + VN
Sbjct: 94 VGKAEDREQLV--AKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 199 LTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVS 258
L LLP + + RG ++ V S A P LG Y SK A+ L T + EL P ++V+
Sbjct: 152 LLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVN 211
Query: 259 IIQPGCFKTESVR----NVGQWEKRKQ 281
+ PG KT+ + N W+ K+
Sbjct: 212 CVVPGIIKTDFSKVFHGNESLWKNFKE 238
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 59.7 bits (143), Expect = 5e-09
Identities = 59/199 (29%), Positives = 84/199 (42%), Gaps = 29/199 (14%)
Query: 74 RPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATV-----LELNSPGAIELRTCC 128
RP+ L + V++TG G G+E A L MG V+ T L+ +EL
Sbjct: 28 RPEMLQ--GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAAS 85
Query: 129 SPRLRLLQMDLT-------KPGDISRVLEFTKA-HTTSTGLWGLVNNAGHNEVVADAELS 180
+ + D+T + G + L+ H T+T L N H+++
Sbjct: 86 AHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL-----NLFHDDI------- 133
Query: 181 PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA 240
R MEVNF + LT LP+L+ S G IV V S AG + YP + AY SK A+
Sbjct: 134 --HHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALD 191
Query: 241 LLMDTFSCELLPWGVKVSI 259
+ E V VSI
Sbjct: 192 GFFSSIRKEYSVSRVNVSI 210
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 59.7 bits (143), Expect = 5e-09
Identities = 59/199 (29%), Positives = 84/199 (42%), Gaps = 29/199 (14%)
Query: 74 RPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATV-----LELNSPGAIELRTCC 128
RP+ L + V++TG G G+E A L MG V+ T L+ +EL
Sbjct: 28 RPEMLQ--GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAAS 85
Query: 129 SPRLRLLQMDLT-------KPGDISRVLEFTKA-HTTSTGLWGLVNNAGHNEVVADAELS 180
+ + D+T + G + L+ H T+T L N H+++
Sbjct: 86 AHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL-----NLFHDDI------- 133
Query: 181 PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA 240
R MEVNF + LT LP+L+ S G IV V S AG + YP + AY SK A+
Sbjct: 134 --HHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALD 191
Query: 241 LLMDTFSCELLPWGVKVSI 259
+ E V VSI
Sbjct: 192 GFFSSIRKEYSVSRVNVSI 210
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 59.7 bits (143), Expect = 5e-09
Identities = 52/190 (27%), Positives = 85/190 (44%), Gaps = 3/190 (1%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMG-FTVLATVLELNSPGAIELRTCCSPRLRLLQMD 138
+A R ++TG SG G A++L G V+++ + N A+ + +
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 139 LTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALE 198
+ K D +++ KA G+ LV +AG N +V + + + VN
Sbjct: 94 VGKAEDREQLV--AKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 199 LTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVS 258
L LLP + + RG ++ V S A P LG Y SK A+ L T + EL P ++V+
Sbjct: 152 LLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVN 211
Query: 259 IIQPGCFKTE 268
+ PG KT+
Sbjct: 212 CVVPGIIKTD 221
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 59.3 bits (142), Expect = 6e-09
Identities = 69/293 (23%), Positives = 127/293 (43%), Gaps = 27/293 (9%)
Query: 58 LAVLAAAGWIA-------LSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMG-FTV 109
+ +LAAA +A +S L P+ L + V++TG SG GK A + G F
Sbjct: 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT 60
Query: 110 LATVLE---LNSPGAIELRTCCSPRLRL-LQMDLTKPGDISRVLEFTKAHTTSTGLWGLV 165
L E L + IE+ + ++ L + +D+++ D ++V K G ++
Sbjct: 61 LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQ--DYNQVENVIKQAQEKLGPVDML 118
Query: 166 NNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSR-GRIVTVGSPAGDM 224
N V E V+TF M +N+ G++ ++ ++ ++ R GRIV V S AG +
Sbjct: 119 VNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQL 178
Query: 225 PYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLL 284
AY SK A+ L + E+ P+ V +++ P T + + + L+
Sbjct: 179 GLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLI 238
Query: 285 ANL-----PQELLQAYGKDYIE-------HLHGQFLHSLRLAMSDLTPVVDAI 325
+ P+++ + KD I+ G L +L M+ +T + + +
Sbjct: 239 SETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGL 291
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 16/206 (7%)
Query: 76 QRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCC---SPRL 132
+R V VLITG G G+ TA + + ++ + ++N G E C ++
Sbjct: 30 RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLV--LWDINKHGLEETAAKCKGLGAKV 87
Query: 133 RLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAEL--SPVATFRSCME 190
+D + DI + KA + LVNNAG VV ++L + E
Sbjct: 88 HTFVVDCSNREDIYSSAKKVKAEIGDVSI--LVNNAG---VVYTSDLFATQDPQIEKTFE 142
Query: 191 VNFFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCE 249
VN TK LP + +++ G IVTV S AG + P L AY +SK A T + E
Sbjct: 143 VNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDE 202
Query: 250 LLP---WGVKVSIIQPGCFKTESVRN 272
L GVK + + P T ++N
Sbjct: 203 LAALQITGVKTTCLCPNFVNTGFIKN 228
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 56.6 bits (135), Expect = 4e-08
Identities = 58/209 (27%), Positives = 87/209 (41%), Gaps = 17/209 (8%)
Query: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTV---------LATVLELNSPGAIELRTCCSP 130
V + V+IT SG GKE A+ + G + L + + A +T +P
Sbjct: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTF-TP 93
Query: 131 RLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCME 190
+L LL + DIS V + K G ++ N +V A + + M+
Sbjct: 94 KLVLLDLS-----DISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMD 148
Query: 191 VNFFGALELTKGLLPLLRSSR-GRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCE 249
N+FG + LTK LLP + S R G+IV V + G P Y SK A D E
Sbjct: 149 ANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAE 208
Query: 250 LLPWGVKVSIIQPGCFKTESV-RNVGQWE 277
+ + V +S + P ++ V G WE
Sbjct: 209 VEEYDVVISTVSPTFIRSYHVYPEQGNWE 237
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 55.5 bits (132), Expect = 9e-08
Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 24/245 (9%)
Query: 56 AALAVLAAAGW--IALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLAT- 112
A L L A W + ++ +R P+A + L+T G G A++L G V+ +
Sbjct: 4 AGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSS 63
Query: 113 ---------VLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWG 163
V L G T C + K D R++ A G+
Sbjct: 64 RKQQNVDQAVATLQGEGLSVTGTVCH---------VGKAEDRERLV--ATAVKLHGGIDI 112
Query: 164 LVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLL-RSSRGRIVTVGSPAG 222
LV+NA N + +++N +TK ++P + + G +V V S A
Sbjct: 113 LVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAA 172
Query: 223 DMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQL 282
P P Y SK A+ L T + EL P ++V+ + PG KT R + +++++
Sbjct: 173 FSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEES 232
Query: 283 LLANL 287
+ L
Sbjct: 233 MKETL 237
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 52.0 bits (123), Expect = 1e-06
Identities = 66/246 (26%), Positives = 104/246 (42%), Gaps = 27/246 (10%)
Query: 50 RLLPPPAALAVLAAAGWIALSRL---ARPQRLPVATRAVLITGCDSGFGKETAKKLDSMG 106
R L P +AL +A A + + A P + + + V++TG ++G GK+TA +L G
Sbjct: 3 RYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRG 62
Query: 107 FTVLATV--LELNSPGAIELR-TCCSPRLRLLQMDLTKPGDISRVLEF-TKAHTTSTGLW 162
++ +E A ++R + + +DL + + EF K +
Sbjct: 63 GNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL---ASLKSIREFAAKIIEEEERVD 119
Query: 163 GLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSR-GRIVTVGS-- 219
L+NNAG V+ + F VN G LT LL L++S RI+ + S
Sbjct: 120 ILINNAG---VMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLA 176
Query: 220 -PAGDMPYPCL----------GAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTE 268
AG + + L AY SK A+ L S L GV V+ + PG +TE
Sbjct: 177 HVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTE 236
Query: 269 SVRNVG 274
R+ G
Sbjct: 237 LGRHTG 242
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/206 (29%), Positives = 91/206 (44%), Gaps = 21/206 (10%)
Query: 83 RAVLITGCDSGFGKETAKKLDSMGFTVLATVLEL--NSPGAIELRT-CCSPRLRLLQMDL 139
+ V+ITG ++G GKETA++L S G V ++ A E+R + ++ + ++DL
Sbjct: 40 KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
Query: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
+ I E A + L+NNAG V+ F + + VN G L
Sbjct: 100 SDTKSIRAFAEGFLAEEKQLHI--LINNAG---VMMCPYSKTADGFETHLGVNHLGHFLL 154
Query: 200 TKGLLPLLR-SSRGRIVTVGSPA---GDMPYPCLG---------AYGTSKAAVALLMDTF 246
T LL L+ S+ R+V V S A G +P+ L AY SK A L
Sbjct: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
Query: 247 SCELLPWGVKVSIIQPGCFKTESVRN 272
+ L GV + PG ++E VR+
Sbjct: 215 AKRLQGTGVTTYAVHPGVVRSELVRH 240
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 50.8 bits (120), Expect = 2e-06
Identities = 57/204 (27%), Positives = 80/204 (39%), Gaps = 12/204 (5%)
Query: 76 QRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCC---SPRL 132
+R VA VLITG G G++T + + + ++N G E C
Sbjct: 30 RRKSVAGEIVLITGAGHGIGRQTTYEFAKR--QSILVLWDINKRGVEETAAECRKLGVTA 87
Query: 133 RLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVN 192
+D + +I R L K + +VNNAG AD + EVN
Sbjct: 88 HAYVVDCSNREEIYRSLNQVKKEVGDVTI--VVNNAG-TVYPADLLSTKDEEITKTFEVN 144
Query: 193 FFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELL 251
G +TK LLP ++ + G IVTV S G P L Y +SK A + EL
Sbjct: 145 ILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQ 204
Query: 252 ---PWGVKVSIIQPGCFKTESVRN 272
G+K S + P T +N
Sbjct: 205 ALGKTGIKTSCLCPVFVNTGFTKN 228
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/177 (29%), Positives = 76/177 (42%), Gaps = 5/177 (2%)
Query: 85 VLITGCDSGFGKETAKKLDSMGFTVLATVLE--LNSPGAIELRTCCSPRLRLLQMDLTKP 142
VL+TG ++G G+E A +G ++ T L R +P++ + D+ P
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
Query: 143 GDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKG 202
V++F A GL LV N SP AT R M+VNF ++LT
Sbjct: 92 EAPESVVQF--ALDKLGGLDYLVLNHIGGAPAGTRARSPQAT-RWLMQVNFVSYVQLTSR 148
Query: 203 LLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
LP L S+G +V V S G +P Y +K A+ + EL V V+I
Sbjct: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,825,885
Number of Sequences: 37866
Number of extensions: 756805
Number of successful extensions: 3189
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 3072
Number of HSP's gapped (non-prelim): 102
length of query: 405
length of database: 18,247,518
effective HSP length: 105
effective length of query: 300
effective length of database: 14,271,588
effective search space: 4281476400
effective search space used: 4281476400
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.