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Search of human proteins with 119220552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119220552 sidekick 1 [Homo sapiens]
(2213 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119220552 sidekick 1 [Homo sapiens] 4463 0.0
gi|222352127 sidekick 2 [Homo sapiens] 2611 0.0
gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken) ... 315 2e-85
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 314 7e-85
gi|75709184 contactin 3 [Homo sapiens] 301 4e-81
gi|4827022 contactin 2 precursor [Homo sapiens] 294 7e-79
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 291 4e-78
gi|7657361 contactin 6 [Homo sapiens] 290 1e-77
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 290 1e-77
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 289 2e-77
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 284 8e-76
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 283 1e-75
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 282 2e-75
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 281 7e-75
gi|7657359 contactin 5 isoform long [Homo sapiens] 274 8e-73
gi|28373129 contactin 5 isoform short [Homo sapiens] 274 8e-73
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 272 3e-72
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 266 1e-70
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 265 3e-70
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 265 5e-70
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 265 5e-70
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 261 4e-69
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 260 1e-68
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 258 3e-68
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 258 3e-68
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 256 1e-67
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 253 1e-66
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 245 3e-64
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 241 4e-63
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 239 3e-62
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 4463 bits (11575), Expect = 0.0
Identities = 2213/2213 (100%), Positives = 2213/2213 (100%)
Query: 1 MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGG 60
MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGG
Sbjct: 1 MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGG 60
Query: 61 DTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGN 120
DTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGN
Sbjct: 61 DTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGN 120
Query: 121 RLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQ 180
RLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQ
Sbjct: 121 RLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQ 180
Query: 181 RKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAI 240
RKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAI
Sbjct: 181 RKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAI 240
Query: 241 TLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPG 300
TLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPG
Sbjct: 241 TLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPG 300
Query: 301 NRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPY 360
NRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPY
Sbjct: 301 NRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPY 360
Query: 361 VCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQW 420
VCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQW
Sbjct: 361 VCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQW 420
Query: 421 YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP 480
YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP
Sbjct: 421 YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP 480
Query: 481 VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI 540
VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI
Sbjct: 481 VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI 540
Query: 541 APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD
Sbjct: 541 APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
Query: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660
PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA
Sbjct: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660
Query: 661 RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSN 720
RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSN
Sbjct: 661 RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSN 720
Query: 721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780
VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR
Sbjct: 721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780
Query: 781 TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ 840
TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ
Sbjct: 781 TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ 840
Query: 841 YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFING 900
YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFING
Sbjct: 841 YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFING 900
Query: 901 INQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960
INQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS
Sbjct: 901 INQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960
Query: 961 TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLT 1020
TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLT
Sbjct: 961 TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLT 1020
Query: 1021 HTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN 1080
HTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN
Sbjct: 1021 HTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN 1080
Query: 1081 ISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTP 1140
ISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTP
Sbjct: 1081 ISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTP 1140
Query: 1141 YTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS 1200
YTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS
Sbjct: 1141 YTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS 1200
Query: 1201 QYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA 1260
QYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA
Sbjct: 1201 QYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA 1260
Query: 1261 GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD 1320
GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD
Sbjct: 1261 GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD 1320
Query: 1321 LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGP 1380
LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGP
Sbjct: 1321 LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGP 1380
Query: 1381 PVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT 1440
PVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT
Sbjct: 1381 PVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT 1440
Query: 1441 DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV 1500
DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV
Sbjct: 1441 DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV 1500
Query: 1501 PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG
Sbjct: 1501 PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
Query: 1561 DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE 1620
DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE
Sbjct: 1561 DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE 1620
Query: 1621 LEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAY 1680
LEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAY
Sbjct: 1621 LEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAY 1680
Query: 1681 NIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY 1740
NIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY
Sbjct: 1681 NIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY 1740
Query: 1741 YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA 1800
YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA
Sbjct: 1741 YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA 1800
Query: 1801 APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW 1860
APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW
Sbjct: 1801 APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW 1860
Query: 1861 QRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTL 1920
QRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTL
Sbjct: 1861 QRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTL 1920
Query: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
Query: 1981 VNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKN 2040
VNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKN
Sbjct: 1981 VNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKN 2040
Query: 2041 CSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDED 2100
CSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDED
Sbjct: 2041 CSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDED 2100
Query: 2101 ICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRA 2160
ICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRA
Sbjct: 2101 ICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRA 2160
Query: 2161 QGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV 2213
QGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV
Sbjct: 2161 QGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV 2213
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 2611 bits (6767), Expect = 0.0
Identities = 1274/2172 (58%), Positives = 1636/2172 (75%), Gaps = 48/2172 (2%)
Query: 84 WALLALQLHLLRAL-AQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDD 142
W LLAL H +RA AQDDV+PYFKTEP Q+HLEGNRLVLTC+AEGSWPLEFKW+ ++
Sbjct: 7 WTLLAL--HQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNN 64
Query: 143 SELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTV 202
ELT +S EY+Y+I SL + AGFYRC+VRNRMGALLQR++EVQVAYMGSF + ++ ++V
Sbjct: 65 RELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSV 124
Query: 203 SQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQ 262
S G AA++ I S+P+PQVTWFR+G KI PS+RIAITLEN LVIL+T DAG YYVQ
Sbjct: 125 SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
Query: 263 AVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPV 322
AVN+KNG+NKTS I L++ G + +APTI++PP N SVVAG+SE TLEC+A+ARP+
Sbjct: 185 AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
Query: 323 EDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFI 382
L + WK++GV ++ G+ RRLTI NPT +D G Y CEA L S+ A+L +
Sbjct: 245 IKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
Query: 383 IEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG 442
+EPP F EPE I+AE+E+ VDI CQA GVP P++ WYKDA + + R++ GG
Sbjct: 305 LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 364
Query: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502
L+I L P+D+G+FQCFA N GE+QT TYL VT+IAP T+ P+D+TV DGM+ +L CE
Sbjct: 365 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 424
Query: 503 VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSL 562
SGAP+PAITW++ ILASGSV++PRF LESG L I+P I DAG YTC A N+ G
Sbjct: 425 TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
Query: 563 NASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTS 622
ASA L VW RT I PP+D VIKGT A++ CG THDPRV++RY+W+KD L S
Sbjct: 485 EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544
Query: 623 RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSH 682
RI ++++GSL ISQTWSGDIG Y+C ++S GGNDSR A L V +LPH+P++ + + ++
Sbjct: 545 RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVE 604
Query: 683 SHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFR 742
A+ L+W +PFDGNSP++ YI+E+SENN+PW V L++V P+ T VTV GL PAR+YQFR
Sbjct: 605 RRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFR 664
Query: 743 VCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802
+CAVN+VG+GQ+S +T R+ LPEEPP+APP+N++ASGRTNQSIM+QWQPPPE+ NG+L+
Sbjct: 665 LCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILK 724
Query: 803 GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTE 862
GYI+RY LAGLP YQ +NIT +VN L+ DLIIWT YEI+VAAYN AGLGV+S VTE
Sbjct: 725 GYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTE 784
Query: 863 YTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVT 922
+TLQGVPT PP NV EA NSTTI+F WN P QFINGINQGYKL+AW + E VT+VT
Sbjct: 785 WTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT 844
Query: 923 IAPDFH-GVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT 981
P+F +H G ++ LKKFT YFTSVLCFTTPGDGP STPQLV T ED PG VGHLSF+
Sbjct: 845 ARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFS 904
Query: 982 EILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041
EILDTSLKVSWQEP EKNGI+TGY+ISWE Y R ++R+TH L + T EY++ GL++LTTY
Sbjct: 905 EILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTY 964
Query: 1042 TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSIS 1101
TI+VAA+T+ G G V++STISSGVPP+LPG P+NL ISNI PRS TLQFRPGYDGKTSIS
Sbjct: 965 TIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSIS 1024
Query: 1102 RWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSP 1161
RW+VE QVG +G+ EEW+ +++ NEPDA+ +E+P+L P+T Y FRM+QVNIVG SP S
Sbjct: 1025 RWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQ 1084
Query: 1162 SSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ 1221
SR IQTLQAPPD+AP +V++RTASETSL LRW+PLP+ +YNGNPESVGY+IKY RSD
Sbjct: 1085 PSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGH 1144
Query: 1222 SSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPE 1281
++ VV DR+ER++TIE+LEEW EY +Q+QAFNA+G+GPWS+ V GRTRESVPS+ P
Sbjct: 1145 GKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPT 1204
Query: 1282 NVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLA 1341
NVSA A +S+ +L+ W+ VPE D+NGL+LGYK++++ KD D +PR +V GN ++SA L
Sbjct: 1205 NVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLT 1264
Query: 1342 GLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP 1401
GL K+VLYE+QVLAFTRIG+G PS P ILERT DD PGPP+ ++FPEVR TSVR++WQPP
Sbjct: 1265 GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
Query: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
PNGIIL YQI +RL +++ +T T + + RQ+TAT L PES Y+FR++A+TR+GWG
Sbjct: 1325 AAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG 1384
Query: 1462 EPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPR 1521
E EA V+TTEKR+RP PP +V Q +V ARS+ L W PGSDG SP+RY+T+Q RELP
Sbjct: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444
Query: 1522 GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581
G W +S+S+SH A++ +VDRL+PFTSYK R+KATNDIGDS+FS E+E++TTLQ P E
Sbjct: 1445 GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA 1504
Query: 1582 PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALH 1641
P +S TPHTT+SVLI+WQPP ++ +NG+L G+RI YREL YE G + + NP A
Sbjct: 1505 PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATW 1564
Query: 1642 AELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAP 1701
AELT+ S + ++ S T EL +L K+RRYE+ M+ YN +GE P+S P EVFVGEA P
Sbjct: 1565 AELTSMYSMRNLSRPSL-TQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP 1623
Query: 1702 AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEP 1761
AP+NV V TA+QL+VTW+PPP +SQNG+IQGYKIY+WEA N TE++K LFL E
Sbjct: 1624 TAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAEN 1683
Query: 1762 VVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821
V+LKNLT +T Y+VS++AFNAAGDGP+S P QG+T QAAP APS + FSE+T+T++NVS
Sbjct: 1684 SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743
Query: 1822 WGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA 1881
W P NGIL+GYR+VYEP +PV GVSK+VTV+V+GN WLKV+DL +GVTY FR++A
Sbjct: 1744 WEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 1803
Query: 1882 RTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARP 1941
+T TYGPE++AN+T GP EG+PG P ++ + +S + + W+ G G P T YVIEARP
Sbjct: 1804 KTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARP 1863
Query: 1942 SDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVE 2001
SDEGLWD+ +KDIP+ +SYT S+D L+ GV+Y+FRV+AVN+ G+G PS+PS +V AQ
Sbjct: 1864 SDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
Query: 2002 APFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY-KNCSTG----KGISTMEESVTL 2056
PFYEEWWFL+V+AL LI ILL+VF L++ GQ+KKY K +G G E ++L
Sbjct: 1924 NPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSL 1983
Query: 2057 DNGGFAALELSSRHLNVKSTFSKKNG--TRSPPRPSPGGLHYSDEDICNKYNGAVLTESV 2114
D F ALEL++R L+VK++F +KNG TRSPPRPSPG LHYSDED+ KYN + ES
Sbjct: 1984 DESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDV-TKYNDLIPAESS 2042
Query: 2115 SLKEKSADASESEATDSDYE---DALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYE 2171
SL EK ++ S+S+ +DS+YE + HSFVNHY+SDPTYYNSW+R+ +G + A +
Sbjct: 2043 SLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRA--QAY 2100
Query: 2172 AVAGSEAGAQLHPVITTQSA---GGVYTP---------------------------AGPG 2201
+ S++G H +T ++ G ++ P PG
Sbjct: 2101 SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG 2160
Query: 2202 ARTPLTGFSSFV 2213
+R P+ GFSSFV
Sbjct: 2161 SRAPIAGFSSFV 2172
>gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken)
[Homo sapiens]
Length = 399
Score = 315 bits (808), Expect = 2e-85
Identities = 162/328 (49%), Positives = 211/328 (64%), Gaps = 10/328 (3%)
Query: 320 RPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
RP+ L + WK++GV ++ G+ RRLTI NPT +D G Y CEA L S+ A+
Sbjct: 54 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 113
Query: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA 439
L ++EPP F EPE I+AE+E+ VDI CQA GVP P++ WYKDA + + R++
Sbjct: 114 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173
Query: 440 SGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAIL 499
GGL+I L P+D+G+FQCFA N GE+QT TYL VT+IAP T+ P+D+TV DGM+ +L
Sbjct: 174 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233
Query: 500 RCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
CE SGAP+PAITW++ ILASGSV++PRF LESG L I+P I DAG YTC A N+
Sbjct: 234 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 293
Query: 560 GSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV---------WK 610
G ASA L VW RT I PP+D VIKGT A++ CG THDPRV++R + W
Sbjct: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRPGAPSGGHWT 353
Query: 611 KDNVALTPSSTSR-IVVEKDGSLLISQT 637
D++ P R V GS L++ T
Sbjct: 354 YDSLYSHPQMRLRGAQVGTRGSRLLANT 381
Score = 90.9 bits (224), Expect = 1e-17
Identities = 82/283 (28%), Positives = 121/283 (42%), Gaps = 32/283 (11%)
Query: 437 VLASGG-------LRIQKLRPEDSGIFQCFA---SNEGGEIQTHTYLDVTNIAPVFTQRP 486
VL SGG L I D+G ++C A S+ + YL V P F + P
Sbjct: 68 VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE-PPQFVKEP 126
Query: 487 VDTTVTDGMTAI--LRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVF 544
+ +T M + + C+ G P P+ITW ++ ++ ++ RF GGLQI+ +
Sbjct: 127 -ERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE--KLTRFRQRNDGGLQISGLV 183
Query: 545 IQDAGNYTCYAANTEGSLNASATLTVWN-RTSIVHPPEDHVVIKGTTATLHCGATHDPRV 603
D G + C+A N G + S L V + +I P D VI G + L C + PR
Sbjct: 184 PDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRP 243
Query: 604 SLRYVWKKDNVALTPSSTS--RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMAR 661
++ W+K L S R + GSLLIS T D G Y+C + G D A
Sbjct: 244 AI--TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 301
Query: 662 LEV-----IELPHSPQNLLVSPNSS------HSHAVVLSWVRP 693
L V I P Q+++ +S H V + +RP
Sbjct: 302 LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQLRP 344
Score = 47.8 bits (112), Expect = 1e-04
Identities = 54/218 (24%), Positives = 91/218 (41%), Gaps = 27/218 (12%)
Query: 104 PYFKTEPGLPQIHLEGNRLV-LTCLAEGSWPLEFKWMRDDS-----ELTTYS--SEYKYI 155
P F EP I E ++V + C A+G P W +D + +LT + ++
Sbjct: 120 PQFVKEPER-HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ 178
Query: 156 IPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPI 215
I L D G ++C RN G + + + TV G + +L
Sbjct: 179 ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL-ACET 237
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAIT----LEN-QLVILATTTSDAGAYYVQAVNEKNGE 270
+ PRP +TW ++G +I+ S + + LE+ L+I T SDAG Y A N + +
Sbjct: 238 SGAPRPAITW-QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 296
Query: 271 NKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
++ + + R I PP ++SV+ G+
Sbjct: 297 EASADLVVWARTR-----------ITKPPQDQSVIKGT 323
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 314 bits (804), Expect = 7e-85
Identities = 328/1247 (26%), Positives = 516/1247 (41%), Gaps = 150/1247 (12%)
Query: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELT-------TYSSEYKYIIPSLQKLDAGFYRCVV 171
G+++ L+C G+ E W R+ L T + I+ + K D G Y+C V
Sbjct: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFV 387
Query: 172 RNRMGALLQRKSEVQVAYMGS---FMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
R L + VQV + K VS L + + P P +TW +
Sbjct: 388 RKDK---LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL-MCNVKGTPLPTITWTLD 443
Query: 229 GHKIIP--SNRIA--ITLENQLV----ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
I+ S+RI+ IT E +V I ++ D G Y A N S + L
Sbjct: 444 DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANN--------SAGVVLY 495
Query: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGL 340
AR P + P N + +AG +T + C P S+ W +N S L
Sbjct: 496 QARI----NVRGPASIRPMKNITAIAGR-DTYIHCRVIGYPY--YSIKWYKN-----SNL 543
Query: 341 HSFGRR---------LTISN-PTSADTGPYVCEAALPGSAFEPARATA---FLFIIEPPY 387
F R L +S+ D G Y C + +P +T+ + + PP+
Sbjct: 544 LPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLV-----QPQLSTSQSVHVTVKVPPF 598
Query: 388 FTAEPESRISAEVEETVDIGCQAMGVPLP-TLQWYKDAISI-SRLQNPRYKVLASGGLRI 445
R S + + V I C + LP T+ W KD I L + + LRI
Sbjct: 599 IQPFEFPRFS--IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRI 656
Query: 446 QKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSG 505
L +G + C A NE ++ + L + + P F +P D G IL C G
Sbjct: 657 SNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGKAVILNCSAEG 715
Query: 506 APKPAITWKRENHILASGSVRIPRFM---------LLESGGLQIAPVFIQDAGNYTCYAA 556
P P I WK S +P+F +L +G L I V +D+G Y C +
Sbjct: 716 YPVPTIVWK------FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS 769
Query: 557 NTEGS-LNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVA 615
N G+ ++ S LTV I P + +G + C A + + +R W+K++
Sbjct: 770 NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRI 827
Query: 616 LTPS------STSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPH 669
+ P ST + E +L I T D G +SC ++ G D + +L V E P
Sbjct: 828 INPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
Query: 670 SPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKV--HLSNVGPEMTG 727
P+ + + + L W FDGNSPI Y +E + W +V P++
Sbjct: 888 PPE---IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944
Query: 728 VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMV 787
T+ + P+ TY R+ A N +G+ + S E + + E P PP+ + ++QSI V
Sbjct: 945 ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT-ITADEAAPDGPPQEVHLEPISSQSIRV 1003
Query: 788 QWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNI---TSPEVNYCLVTDLIIWTQYEIQ 844
W+ P + NG++RGY + YR G +Q I TS + + +L +TQY +
Sbjct: 1004 TWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
Query: 845 VAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQG 904
V A N AG G S+ + TL+ VP+ PP+NVQ A + +I W+ ++ +NGI QG
Sbjct: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
Query: 905 YKLLAW----PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960
++++ W + E + T P + L+K+T Y VL FT GDG S
Sbjct: 1124 FRVIYWANLMDGELGEIKNITTTQPSL------ELDGLEKYTNYSIQVLAFTRAGDGVRS 1177
Query: 961 TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQI-SWEVYGRNDSRL 1019
T+ED PG + + + VSW PL+ NGII Y + Y S
Sbjct: 1178 EQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEF 1237
Query: 1020 THTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVIS 1079
+ +S Y+I LS Y++ V AVT+ G G SS I + P L AP+ ++
Sbjct: 1238 EASPDS--FSYRIPNLSRNRQYSVWVVAVTSAGRG--NSSEIITVEP--LAKAPARILT- 1290
Query: 1080 NISPRSATLQFRPGYDGKTSISRWI--VEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPN 1137
+ G T + W+ + A+GD V ++ N + +
Sbjct: 1291 --------------FSG-TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR 1335
Query: 1138 LTPYTHYRFRMKQVNIVGPSPYS-------PSSRVIQTL--QAPPDVAPTSVTVRTASET 1188
+ +++ F ++ V YS S +I L Q PPD +TV + +
Sbjct: 1336 RSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD--QPRLTVSKTTSS 1393
Query: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEY 1248
S+ L W+P NG GY ++Y S+ S ER + +E L+ Y
Sbjct: 1394 SITLSWLP----GDNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWY 1447
Query: 1249 ELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILL 1295
+ + A N VG G SE++ +T P + E ++++T++ L
Sbjct: 1448 KFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRL 1494
Score = 207 bits (526), Expect = 1e-52
Identities = 285/1192 (23%), Positives = 470/1192 (39%), Gaps = 118/1192 (9%)
Query: 124 LTCLAEGSWPLEFKWMRDDSEL------------TTYSSEYKYI-IPSLQKLDAGFYRCV 170
L C +G+ W DD + T+ + Y+ I S Q D G YRC
Sbjct: 426 LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
Query: 171 VRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGH 230
N G +L + + + V S + T GR ++ I YP + W++ +
Sbjct: 486 ANNSAGVVLYQ-ARINVRGPASIRPM-KNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSN 542
Query: 231 KIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPET 290
++P N + EN G + V ++ E + + ++ + + T ++
Sbjct: 543 -LLPFNHRQVAFENN-----------GTLKLSDVQKEVDEGEYT--CNVLVQPQLSTSQS 588
Query: 291 MAPTIVVPPGNRSV----VAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLH----- 341
+ T+ VPP + + + C+ + + +++TW+++G I L
Sbjct: 589 VHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLP-ITITWQKDGRPIPGSLGVTIDN 647
Query: 342 -SFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEV 400
F L ISN + G Y C A +A E L + PP F +P +
Sbjct: 648 IDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ---LIVRVPPKFVVQPRDQ-DGIY 703
Query: 401 EETVDIGCQAMGVPLPTLQW-YKDAISISRLQ----NPRYKVLASGGLRIQKLRPEDSGI 455
+ V + C A G P+PT+ W + + + Q N R +VL++G L I+ + EDSG
Sbjct: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
Query: 456 FQCFASNE-GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWK 514
+ C SN+ G ++ YL V I + T P T T G + C G + W+
Sbjct: 764 YLCKVSNDVGADVSKSMYLTV-KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822
Query: 515 RENHILASGSVRIPRFMLLES-------GGLQIAPVFIQDAGNYTCYAANTEGSLNASAT 567
+E+ I+ + + R+++ LQI P +D+G ++C+A N+ G
Sbjct: 823 KEDRII---NPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQ 879
Query: 568 LTVWNRTSIVHPPEDHVV-IKGTTATLHCGATHDPRVSLR-YVWKKDNVALTPSSTSRIV 625
LTV PPE + +K T TL D + Y + N + + S R
Sbjct: 880 LTVQEPPD---PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT- 935
Query: 626 VEKDGSLLISQTWSGDI---GDYSCEIV-------SEGGNDSRMARLEVIELPHSPQNLL 675
KD S ++ DI YS + SE N+ + E PQ +
Sbjct: 936 --KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP-DGPPQEVH 992
Query: 676 VSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTG----VTVS 731
+ P SS S V + N I Y + E ++ + + + +G T+
Sbjct: 993 LEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLD 1052
Query: 732 GLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQP 791
L Y V A N G G S E L E+ PS PP+N+ A + +SI + W
Sbjct: 1053 NLNKFTQYGLVVQACNRAGTGPSSQEIITTTL-EDVPSYPPENVQAIATSPESISISWST 1111
Query: 792 PPETEHNGVLRGYILRYRLAGLPGEYQQ-RNITSPEVNYCLVTDLIIWTQYEIQVAAYNG 850
+ NG+L+G+ + Y + GE + +NIT+ + + L L +T Y IQV A+
Sbjct: 1112 LSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL-DGLEKYTNYSIQVLAFTR 1170
Query: 851 AGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAW 910
AG GV S + T + VP PP V+ A +++ + W PP + +NGI + Y +
Sbjct: 1171 AGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSWLPPLK--LNGIIRKYTVFC- 1226
Query: 911 PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQED 970
P ++ +PD I NL + Y V+ T+ G G S V
Sbjct: 1227 SHPYPTVISEFEASPDSFSYR---IPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAK 1283
Query: 971 KPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEY 1030
P + L+F+ + T P + G S V DS T +L +
Sbjct: 1284 APARI--LTFSGTVTTPWMKDIVLPCKAVG-----DPSPAVKWMKDSNGTPSLVTIDGRR 1336
Query: 1031 KIQGLSSLTTYTI---DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSAT 1087
I S T+ D + + S I + +P L +S + S T
Sbjct: 1337 SIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSIT 1396
Query: 1088 LQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFR 1147
L + PG +G +SI +I++ + E+W + P + + NL T Y+F
Sbjct: 1397 LSWLPGDNGGSSIRGYILQYSED---NSEQWGSF---PISPSERSYRLENLKCGTWYKFT 1450
Query: 1148 MKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPE 1207
+ N VGP S +TL P + + + T +RL + D G
Sbjct: 1451 LTAQNGVGPGRISEIIEA-KTLGKEPQFSKEQELFASINTTRVRLNLIGWND----GGCP 1505
Query: 1208 SVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVG 1259
+ ++Y AQ S L + + + +L+E YELQM+ N+ G
Sbjct: 1506 ITSFTLEYRPFGTTVWTTAQRTS--LSKSYILYDLQEATWYELQMRVCNSAG 1555
Score = 204 bits (519), Expect = 8e-52
Identities = 265/1112 (23%), Positives = 442/1112 (39%), Gaps = 95/1112 (8%)
Query: 117 LEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYK----YIIPSLQKLDAGFYRCVVR 172
+ G R+ L C A G +++W++D+ L K +I +++ D+G Y C V
Sbjct: 237 MAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296
Query: 173 NRMG-ALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHK 231
NR G A + + V+ + RK S + + +T +++W+R G
Sbjct: 297 NRYGTAKVIGRLYVKQPLKATI---SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEI 353
Query: 232 IIPSNRIAITLEN--QLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPE 289
+ P + IT N L++ SD GAY Q K +K S ++ + + GTP+
Sbjct: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAY--QCFVRK---DKLSAQDYVQVVLEDGTPK 408
Query: 290 TMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW--------KRNGVRITSGLH 341
++ + VV+ + +L C P+ ++TW K RI+ +
Sbjct: 409 ------IISAFSEKVVSPAEPVSLMCNVKGTPLP--TITWTLDDDPILKGGSHRISQMIT 460
Query: 342 SFGR---RLTISNPTSADTGPYVCEA-ALPGSAFEPARATAFLFIIEPPYFTAEPESRIS 397
S G L IS+ D G Y C A G AR + P + P I+
Sbjct: 461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARIN-----VRGP-ASIRPMKNIT 514
Query: 398 AEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPE-DSGIF 456
A I C+ +G P +++WYK++ ++ + + +G L++ ++ E D G +
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNS-NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEY 573
Query: 457 QCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKP-AITWKR 515
C + ++ T + VT P F Q + G + C V P ITW++
Sbjct: 574 TCNVLVQ-PQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK 632
Query: 516 ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS 575
+ + GS+ + + + L+I+ + + GNYTC A N ++ + L V
Sbjct: 633 DGRPI-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK 691
Query: 576 IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP-----SSTSRIVVEKDG 630
V P D I G L+C A P ++ VWK A P + RI V +G
Sbjct: 692 FVVQPRDQDGIYGKAVILNCSAEGYPVPTI--VWKFSKGAGVPQFQPIALNGRIQVLSNG 749
Query: 631 SLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP----HSPQNLLVSPNSSHSHAV 686
SLLI D G Y C++ ++ G D + +++P P L + +
Sbjct: 750 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSC 809
Query: 687 VLSWVRPFDGNSPILYYIVE----LSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFR 742
G PI+ + ++ + + V VG E+ T F
Sbjct: 810 TA------HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFF 863
Query: 743 VC-AVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVL 801
C A+N G + + + + P +PP K++ A ++I ++W + N +
Sbjct: 864 SCHAINSYGEDRGIIQLT-VQEPPDPPEIEIKDVKA-----RTITLRW--TMGFDGNSPI 915
Query: 802 RGYILRYRLAGLPGEYQQR-NITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAV 860
GY + + + QR SP++N + D+ + Y I++ A N G S +
Sbjct: 916 TGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL 975
Query: 861 TEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTV 920
T + P PPQ V E ++S +I+ W P + NGI +GY++
Sbjct: 976 TITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF 1035
Query: 921 VTIAPDFHGVHHGH-ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPG-AVGHL 978
I+ D G + + NL KFT Y V G GP S + T ED P ++
Sbjct: 1036 NIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
Query: 979 SFTEILDTSLKVSWQEPLEK--NGIITGYQISWEVYGRN--DSRLTHTLNSTTHE--YKI 1032
S+ +SW ++ NGI+ G+++ +Y N D L N TT + ++
Sbjct: 1096 QAIATSPESISISWSTLSKEALNGILQGFRV---IYWANLMDGELGEIKNITTTQPSLEL 1152
Query: 1033 QGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRP 1092
GL T Y+I V A T G G V S I + D+PG P+ + + S + + P
Sbjct: 1153 DGLEKYTNYSIQVLAFTRAGDG-VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLP 1211
Query: 1093 GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVN 1152
I ++ V + E E PD+ IPNL+ Y + V
Sbjct: 1212 PLKLNGIIRKYTV------FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVT 1265
Query: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRT 1184
G S V +AP + S TV T
Sbjct: 1266 SAGRGNSSEIITVEPLAKAPARILTFSGTVTT 1297
Score = 169 bits (428), Expect = 3e-41
Identities = 101/372 (27%), Positives = 182/372 (48%), Gaps = 26/372 (6%)
Query: 1468 VITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTY 1527
+I +E P PP + +V AR++ L+W G DG SPI + ++ + W +
Sbjct: 877 IIQLTVQEPPDPPE---IEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSDSWDSA 932
Query: 1528 --SSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSV 1585
+ +S + + + + P ++Y +R+ A N IG S+ S+E +T + P PP V
Sbjct: 933 QRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL-TITADEAAPDGPPQEV 991
Query: 1586 SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELT 1645
P ++ S+ + W+ P+ NG+++GY+I YRE Y G + +
Sbjct: 992 HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYRE--YSTGGNFQFNII----------- 1038
Query: 1646 AQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP 1705
+V++S S + L +L K+ +Y +++ A N G P+S + E P+ P
Sbjct: 1039 ------SVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPP 1092
Query: 1706 QNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRL 1765
+NVQ + + ++W E+ NG +QG+++ YW E ++K + +P + L
Sbjct: 1093 ENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL 1152
Query: 1766 KNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEP 1825
L +T Y + + AF AGDG +S+ RT + PG P+ + + +++ + VSW P
Sbjct: 1153 DGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP 1212
Query: 1826 AAANGILQGYRV 1837
NGI++ Y V
Sbjct: 1213 LKLNGIIRKYTV 1224
Score = 165 bits (417), Expect = 5e-40
Identities = 156/574 (27%), Positives = 257/574 (44%), Gaps = 59/574 (10%)
Query: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125
PPD P + I ++ R+ TL++ G+DG + I+ + +E + + W + +
Sbjct: 885 PPD----PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECK----NKSDSWDSAQRTK 936
Query: 1126 N-EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL-QAPPDVAPTSVTVR 1183
+ P I ++ P + Y RM N +G S PS+ + T +A PD P V +
Sbjct: 937 DVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKS--EPSNELTITADEAAPDGPPQEVHLE 994
Query: 1184 TASETSLRLRWVPLPDSQYNG--NPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEE 1241
S S+R+ W NG +GYR + Q + ++ S E +T++
Sbjct: 995 PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDN 1053
Query: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
L ++ +Y L +QA N G GP S+ + T E VPS PENV A A S I ++W+++
Sbjct: 1054 LNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLS 1113
Query: 1302 EQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL-LAGLRKFVLYELQVLAFTRIG 1360
++ NG++ G+++++ A +D E I TQ +L L GL K+ Y +QVLAFTR G
Sbjct: 1114 KEALNGILQGFRVIYWANLMDGE-LGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG 1172
Query: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASS 1420
+GV S I RTK+D PGPP + + V + W PP + NGII Y + +
Sbjct: 1173 DGVRSEQ-IFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVF--CSHP 1229
Query: 1421 SPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPP 1480
P + E + +L+ Y + A T G G E +IT E + AP
Sbjct: 1230 YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE--IITVEPLAK-APA 1286
Query: 1481 R--------------ELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQT 1526
R ++++P V S ++W+ S+G + G
Sbjct: 1287 RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTID--------GRRSI 1338
Query: 1527 YSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVS 1586
+S+ + ++ ++ S A N+ G S E +Q P +P +VS
Sbjct: 1339 FSNG------SFIIRTVKAEDSGYYSCIANNNWG----SDEIILNLQVQVPPDQPRLTVS 1388
Query: 1587 ATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE 1620
T T+SS+ + W P ++ ++GY + Y E
Sbjct: 1389 KT--TSSSITLSWLP--GDNGGSSIRGYILQYSE 1418
Score = 160 bits (404), Expect = 2e-38
Identities = 165/657 (25%), Positives = 266/657 (40%), Gaps = 71/657 (10%)
Query: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSS-PHTFTT 1427
I++ T + P PP + +V+ ++ + W + N I GY I + S S T
Sbjct: 877 IIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935
Query: 1428 VEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ 1487
+V + T D+ P S Y R+ AK R G EP IT ++ PP+E V
Sbjct: 936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQE--VHL 993
Query: 1488 AEVTARSLRLQWVPGSDGASP--IRYFTMQVRELPRG---EWQTYSSSISHEATACVVDR 1542
++++S+R+ W IR + + RE G ++ S S ++ +D
Sbjct: 994 EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053
Query: 1543 LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPP 1602
L FT Y L ++A N G S E TTL+DVP PP +V A + S+ I W
Sbjct: 1054 LNKFTQYGLVVQACNRAGTGPSSQEI-ITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112
Query: 1603 RDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMC 1662
E+LNG+LQG+R+ Y A L + N ++T
Sbjct: 1113 SKEALNGILQGFRVIY----------------------WANLMDGELGEIKNITTTQPSL 1150
Query: 1663 ELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW 1722
EL L+KY Y + + A+ G+ S + E P P V+ +AS + V+W
Sbjct: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSW 1209
Query: 1723 DPPPPESQNGNIQGYKIY----YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSI 1778
PP NG I+ Y ++ Y S+ E + R+ NL+ + +Y V +
Sbjct: 1210 --LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSY------RIPNLSRNRQYSVWV 1261
Query: 1779 SAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVV 1838
A +AG G S+ AP L FS T+ W I+ + V
Sbjct: 1262 VAVTSAGRGNSSEIITVEPLAKAPAR--ILTFSG----TVTTPW-----MKDIVLPCKAV 1310
Query: 1839 YEPLAPVQ------GVSKVVTVEVRGNW--QRWLKVRDLTKGVTYFFRVQARTITYGPEL 1890
+P V+ G +VT++ R + +R + + ++ A E+
Sbjct: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
Query: 1891 QANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMF 1950
N+ + P PR + ++S +TL W G +G + GY+++ + W F
Sbjct: 1371 ILNLQV---QVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSF 1427
Query: 1951 VKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEE 2007
P S + + L+ L+ G Y+F + A N G G S A + E F +E
Sbjct: 1428 ----PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480
Score = 138 bits (347), Expect = 7e-32
Identities = 299/1532 (19%), Positives = 568/1532 (37%), Gaps = 200/1532 (13%)
Query: 117 LEGNRLVLTCLAEGS---WPLEFKWMRDDSELTTYS-----SEYKYIIPSLQKLDAGF-Y 167
+ GN V C+ S + W +D L + S S I +Q D + Y
Sbjct: 136 MRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNY 195
Query: 168 RCVVRNRMGALLQRKSEVQVAYMG------SFMDT-DQRKTVSQGRAAILNLLPITSYPR 220
RC+ R+R ++ + ++ S +D D RK ++ R + +P
Sbjct: 196 RCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELP--CKALGHPE 253
Query: 221 PQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
P W ++ + S R T+ L+I SD+G+Y + N
Sbjct: 254 PDYRWLKDNMPLELSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNR------------YG 300
Query: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG------- 333
A+ +G P + + S+ +L C S ED ++W RNG
Sbjct: 301 TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSC--SVTGTEDQELSWYRNGEILNPGK 358
Query: 334 -VRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFII----EPPYF 388
VRIT H L + + +D G Y C + A ++ ++ P
Sbjct: 359 NVRITGINHE---NLIMDHMVKSDGGAYQCFVRK-----DKLSAQDYVQVVLEDGTPKII 410
Query: 389 TAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY-KVLASGG----- 442
+A E +S E V + C G PLPT+ W D I + + R +++ S G
Sbjct: 411 SAFSEKVVSPA--EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSY 468
Query: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPV-DTTVTDGMTAILRC 501
L I + D G+++C A+N G + ++V A + RP+ + T G + C
Sbjct: 469 LNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI---RPMKNITAIAGRDTYIHC 525
Query: 502 EVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ-DAGNYTCYAANTEG 560
V G P +I W + +++L ++ +G L+++ V + D G YTC +
Sbjct: 526 RVIGYPYYSIKWYKNSNLLPFNHRQVA---FENNGTLKLSDVQKEVDEGEYTCNVL-VQP 581
Query: 561 SLNASATLTVWNRTS-IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPS 619
L+ S ++ V + + P E G + C + + W+KD + P
Sbjct: 582 QLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD-LPITITWQKDGRPI-PG 639
Query: 620 STSRIV--VEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
S + ++ SL IS G+Y+C +E ++L V P +V
Sbjct: 640 SLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV----RVPPKFVVQ 695
Query: 678 PNSS---HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLT 734
P + AV+L+ P+ + + S+ + + + ++ L
Sbjct: 696 PRDQDGIYGKAVILNCSAE---GYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL 752
Query: 735 PARTYQ----FRVCAV-NEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQS----- 784
+ + +C V N+VG + + +P S P + G+ +
Sbjct: 753 IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAH 812
Query: 785 ----IMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ 840
I+V+W+ + + ++ + RY +++ EV +++ L I
Sbjct: 813 GEKPIIVRWE-----KEDRIINPEMARYL------------VSTKEVGEEVISTLQILPT 855
Query: 841 YEIQVAAYNGAGLGVFS--RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFI 898
++ + + R + + T+Q P P ++ + T+++ I
Sbjct: 856 VREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPI 915
Query: 899 NGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGP 958
G + K + D+ + ++P + I ++ + Y + G
Sbjct: 916 TGYDIECKNKSDSWDSAQRTK--DVSPQLNSAT---IIDIHPSSTYSIRMYAKNRIGKSE 970
Query: 959 PSTPQLVWTQEDKP-GAVGHLSFTEILDTSLKVSWQEPLE--KNGIITGYQISWEVYGRN 1015
PS + E P G + I S++V+W+ P + +NGII GYQI + Y
Sbjct: 971 PSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG 1030
Query: 1016 DSRLTHTLNSTT----HEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPG 1071
+ + ++ T Y + L+ T Y + V A GTG + I++ + D+P
Sbjct: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLE-DVPS 1089
Query: 1072 -APSNLVISNISPRSATLQFRP-------GYDGKTSISRW--IVEGQVGAIGDEEEWVTL 1121
P N+ SP S ++ + G + W +++G++G I + +T
Sbjct: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKN----ITT 1145
Query: 1122 YEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPS--SRVIQTLQAPPDVAPTS 1179
+ LE+ L YT+Y ++ G S +R + + PP
Sbjct: 1146 TQPS-------LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPP----AG 1194
Query: 1180 VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTI 1239
V AS + + + W LP + NG + + + S + +++ + + I
Sbjct: 1195 VKAAAASASMVFVSW--LPPLKLNG----IIRKYTVFCSHPYPTVISEFEASPDSFSYRI 1248
Query: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
L +Y + + A + G G SE++ V A + +IL +
Sbjct: 1249 PNLSRNRQYSVWVVAVTSAGRGNSSEII--------------TVEPLAKAPARILTFSGT 1294
Query: 1300 VPEQDQNGLILGYKILFRAKDLDPEPRSHIVR-GNHTQSALLAGLRKFVLYELQVLA--- 1355
V ++L K + DP P ++ N T S + R+ + +
Sbjct: 1295 VTTPWMKDIVLPCKAVG-----DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349
Query: 1356 -------FTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGII 1408
++ I N + I+ + P RL + +S+ + W P + I
Sbjct: 1350 KAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSI 1409
Query: 1409 LGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATV 1468
GY + Y + + + + + + R + +L + Y F L+A+ G G E
Sbjct: 1410 RGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIE 1467
Query: 1469 ITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528
T +E + L A + +RL + +DG PI FT++ R W T
Sbjct: 1468 AKTLGKEPQFSKEQELF--ASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTT-- 1523
Query: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
+ + + + ++ L+ T Y+L+++ N G
Sbjct: 1524 AQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
Score = 123 bits (309), Expect = 2e-27
Identities = 114/493 (23%), Positives = 197/493 (39%), Gaps = 23/493 (4%)
Query: 167 YRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR--PQVT 224
Y C N G + + ++ + + + +G A+ + +S V+
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Query: 225 WFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKN--GENKTSPFIHLSIA 282
W ++ ++ +R IT L I D G Y + + GE + S L ++
Sbjct: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVS 218
Query: 283 RDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHS 342
P AP+I+ +R +AG L C A P D + ++
Sbjct: 219 ----DPANSAPSILDGFDHRKAMAGQ-RVELPCKALGHPEPDYRWLKDNMPLELSGRFQK 273
Query: 343 FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEE 402
L I N +D+G YVCE + + + A+ L++ +P T P ++ + V
Sbjct: 274 TVTGLLIENIRPSDSGSYVCEVS---NRYGTAKVIGRLYVKQPLKATISPR-KVKSSVGS 329
Query: 403 TVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASN 462
V + C G L WY++ ++ +N R + L + + D G +QCF
Sbjct: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
Query: 463 EGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENH-ILA 521
+ Q + + + + P + V+ L C V G P P ITW ++ IL
Sbjct: 390 DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILK 449
Query: 522 SGSVRIPRFMLLES---GGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
GS RI + + E L I+ ++D G Y C A N+ G + A + V SI
Sbjct: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI-R 508
Query: 579 PPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTW 638
P ++ I G +HC P S++ W K N L P + ++ E +G+L +S
Sbjct: 509 PMKNITAIAGRDTYIHCRVIGYPYYSIK--WYK-NSNLLPFNHRQVAFENNGTLKLSDVQ 565
Query: 639 SG-DIGDYSCEIV 650
D G+Y+C ++
Sbjct: 566 KEVDEGEYTCNVL 578
Score = 117 bits (294), Expect = 1e-25
Identities = 139/616 (22%), Positives = 252/616 (40%), Gaps = 57/616 (9%)
Query: 978 LSFTEILDTSLKVSWQEPLEKNGIITGYQI-------SWEVYGRNDSRLTHTLNSTTHEY 1030
+ ++ ++ + W + N ITGY I SW+ R ++ LNS T
Sbjct: 891 IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKD-VSPQLNSAT--- 946
Query: 1031 KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQF 1090
I + +TY+I + A +G ++ + G P + + IS +S + +
Sbjct: 947 -IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTW 1005
Query: 1091 RPGYDGKTSISRWIVEG-QVG----AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYR 1145
+ K + I+ G Q+G + G ++ + + D+++ + NL +T Y
Sbjct: 1006 KAP---KKHLQNGIIRGYQIGYREYSTGGNFQF-NIISVDTSGDSEVYTLDNLNKFTQYG 1061
Query: 1146 FRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGN 1205
++ N G P S + TL+ P P +V S S+ + W L NG
Sbjct: 1062 LVVQACNRAGTGP-SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGI 1120
Query: 1206 PESVGYRIKYWRSDLQSSAVAQVVS-DRLEREFTIEELEEWMEYELQMQAFNAVGAGPWS 1264
+ G+R+ YW ++L + ++ + + ++ LE++ Y +Q+ AF G G S
Sbjct: 1121 LQ--GFRVIYW-ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRS 1177
Query: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
E + RT+E VP P V A A S++ + ++W +P NG+I Y + P
Sbjct: 1178 EQIFTRTKEDVPGP-PAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTVF--CSHPYPT 1232
Query: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
S + S + L + Y + V+A T G G S + +E A P L
Sbjct: 1233 VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL---AKAPARIL 1289
Query: 1385 VFPEVRLT----SVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ---- 1436
F T + + + +P+ + + S+ + T++ ++
Sbjct: 1290 TFSGTVTTPWMKDIVLPCKAVGDPSPAV-----KWMKDSNGTPSLVTIDGRRSIFSNGSF 1344
Query: 1437 FTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLR 1496
T A +S Y S WG + ++ + + P PR + ++ T+ S+
Sbjct: 1345 IIRTVKAEDSGYY---SCIANNNWGS--DEIILNLQVQVPPDQPR---LTVSKTTSSSIT 1396
Query: 1497 LQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKAT 1556
L W+PG +G S IR + +Q E +W ++ S S + ++ L+ T YK L A
Sbjct: 1397 LSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR--LENLKCGTWYKFTLTAQ 1454
Query: 1557 NDIGDSDFSSETEAVT 1572
N +G S EA T
Sbjct: 1455 NGVGPGRISEIIEAKT 1470
Score = 116 bits (290), Expect = 3e-25
Identities = 205/928 (22%), Positives = 335/928 (36%), Gaps = 164/928 (17%)
Query: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKI-----------LFRAKDLDPEPRSH 1328
P + + V + I L WT D N I GY I R KD+ P+ S
Sbjct: 888 PPEIEIKDVKARTITLRWTM--GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSA 945
Query: 1329 IVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE 1388
+ H S Y +++ A RIG PS L + + GPP +
Sbjct: 946 TIIDIHPSST----------YSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEP 995
Query: 1389 VRLTSVRIVWQPPEE--PNGIILGYQIAYRLASSSPH---TFTTVEVGATVRQFTATDLA 1443
+ S+R+ W+ P++ NGII GYQI YR S+ + +V+ +T +L
Sbjct: 996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN 1055
Query: 1444 PESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQWVPG 1502
+ Y + A R G G P +ITT + P+ P E + QA T+ S+ + W
Sbjct: 1056 KFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENV--QAIATSPESISISWSTL 1112
Query: 1503 S--------DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLK 1554
S G I + + EL GE + +I+ + +D L +T+Y +++
Sbjct: 1113 SKEALNGILQGFRVIYWANLMDGEL--GEIK----NITTTQPSLELDGLEKYTNYSIQVL 1166
Query: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGY 1614
A GD SE T +DVPG PP V A + S V + W PP LNG+++ Y
Sbjct: 1167 AFTRAGDG-VRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSWLPPL--KLNGIIRKY 1222
Query: 1615 RIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYE 1674
++ H T S F+ +S S + +L + R+Y
Sbjct: 1223 TVF---------------------CSHPYPTVISEFE---ASPDSFSYRIPNLSRNRQYS 1258
Query: 1675 VIMTAYNIIGESPASAPVEVFVGEAAPA--MAPQNVQVTPLTASQL---EVTWDPPPPES 1729
V + A G +S + V APA + TP + + DP P
Sbjct: 1259 VWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318
Query: 1730 QNGNIQGYKIYYWEADSQNETEKMKV-----LFLPEPVVRLKNLTSHTKYLVSISAFNAA 1784
W DS + + +F + + Y I+ N
Sbjct: 1319 ------------WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
Query: 1785 GDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAP 1844
D + Q Q P P L S+ TS+++ +SW ++GY + Y
Sbjct: 1367 SDEIILNLQV----QVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS 1421
Query: 1845 VQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSP- 1903
Q S ++ +R ++ +L G Y F + A+ GP + I G
Sbjct: 1422 EQWGSFPISPS-----ERSYRLENLKCGTWYKFTLTAQN-GVGPGRISEIIEAKTLGKEP 1475
Query: 1904 --GSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSY 1961
+++ + + + + L + G P T + +E RP +W R++ S
Sbjct: 1476 QFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW----TTAQRTSLSK 1531
Query: 1962 TLSLDKLRQGVTYEFRVVAVNEAGYGEPS-------------NPSTAVSAQVEAPFYEEW 2008
+ L L++ YE ++ N AG E P Q E
Sbjct: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNE 1591
Query: 2009 WFLLVMALSSLIVILLVVFALVL----HGQNKKYKNCSTGKGISTMEESVTLDNGGFAAL 2064
+++ +S ++V +L++F L+L + ++ K K ++ M
Sbjct: 1592 GLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEM-------------- 1637
Query: 2065 ELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADAS 2124
L S++ T SK+ T P +L E E D S
Sbjct: 1638 -LMSKNTRTSDTLSKQQQTLRMHIDIP--------------RAQLLIEERDTMETIDDRS 1682
Query: 2125 ESEATDSDYEDALPKHSF----VNHYMS 2148
TD+D+ +A + S HY S
Sbjct: 1683 TVLLTDADFGEAAKQKSLTVTHTVHYQS 1710
Score = 68.2 bits (165), Expect = 9e-11
Identities = 76/299 (25%), Positives = 118/299 (39%), Gaps = 38/299 (12%)
Query: 406 IGCQAMGVPLPTLQWY----KDAISISRLQNPRYKVLASGGLRIQKLRPED------SGI 455
+ C A G+P TL+WY ++ + +++ V +G L+I P
Sbjct: 44 VPCPAAGIPPVTLRWYLATGEEIYDVPGIRH----VHPNGTLQIFPFPPSSFSTLIHDNT 99
Query: 456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAIT--- 512
+ C A N G+I++ + +T R D G A+ +C + + + IT
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Query: 513 WKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA-GNYTC-----YAANTEGSLNASA 566
W+++ L SGS RF++ +G L I V +D NY C Y T S +A
Sbjct: 160 WEKDTVSLVSGS----RFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
Query: 567 TLT--VWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRI 624
++ + SI+ + + G L C A P Y W KDN+ L S +
Sbjct: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPD--YRWLKDNMPLELSGRFQK 273
Query: 625 VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHS 683
V LLI D G Y CE+ + G + RL V P +SP S
Sbjct: 274 TVT---GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV----KQPLKATISPRKVKS 325
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 301 bits (772), Expect = 4e-81
Identities = 276/1030 (26%), Positives = 439/1030 (42%), Gaps = 88/1030 (8%)
Query: 104 PYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKY------- 154
P F EP + + E ++ L C A G+ ++W + S++ S E++Y
Sbjct: 26 PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDM-SMEHRYKLNGGNL 84
Query: 155 -IIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVS--QGRAAILN 211
+I + D G Y+C N +G ++ R++++Q AY+ +F T R TVS +G+ +L
Sbjct: 85 VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFK-TKMRSTVSVREGQGVVLL 143
Query: 212 LLPITSYPRPQVTW-FREGHKIIP--SNRIAITLENQLVILATTTSDAGAY---YVQAVN 265
P W F E + S R L I SD G Y V
Sbjct: 144 CGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVT 203
Query: 266 EKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDL 325
+P + R G P I V A S LEC A P+ +
Sbjct: 204 NARVLGSPTPLV----LRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQI 259
Query: 326 SVTWKRN-GVRITSG--LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFI 382
+ W+R+ G+ +S L F L I N D G Y C A S + +
Sbjct: 260 N--WRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAE--NSRGKNVARGRLTYY 315
Query: 383 IEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG 442
+P + + I+ VE+++ C+A G P P+ +W K+ ++ + + + +G
Sbjct: 316 AKPHWVQLIKDVEIA--VEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQ---IENGA 370
Query: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD--TTVTDGMTAILR 500
L I L DSG+FQC A N+ G + + L V AP F++ P+ V G L
Sbjct: 371 LTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLD 430
Query: 501 CEVSGAPKPAITWKRENHILASGSVRIP---RFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
C+ +P+ +WK+ G V + R LL GGL+IA V DAG YTC A N
Sbjct: 431 CKPRASPRALSSWKK-------GDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAEN 483
Query: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVW-------- 609
G N + L V T I P + V G + L C HDP + + + W
Sbjct: 484 QFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALAD 543
Query: 610 -KKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP 668
KKD S ++ G L+I G Y C + + + S A L V P
Sbjct: 544 FKKDG-----SHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSP 598
Query: 669 HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVG--PEMT 726
P+N+ V + + LSW D +SP++ Y ++ +P+ V V PE+
Sbjct: 599 GPPENVKVDEITDTT--AQLSWKEGKDNHSPVISYSIQA---RTPFSVGWQTVTTVPEVI 653
Query: 727 G-----VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRT 781
TV L P Y+FRV A N++G G+ S + ++ E P PP + G +
Sbjct: 654 DGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGS 713
Query: 782 NQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEV-NYCLVTDLII-WT 839
+++ W P PE NG GY++ +R G+ + Q +TSP+ Y + I+ ++
Sbjct: 714 RSELVITWDPVPEELQNGEGFGYVVAFRPLGVT-TWIQTVVTSPDTPRYVFRNESIVPYS 772
Query: 840 QYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFIN 899
YE++V YN G G FS T ++ + PT P V +++S+ I+ WN P + N
Sbjct: 773 PYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSN 832
Query: 900 GINQGYKLLAWPADA-PEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGP 958
G GY++ W E+ + + +A + + LK AY+T+V + + G GP
Sbjct: 833 GHLLGYEVRYWNGGGKEESSSKMKVAGN---ETSARLRGLKSNLAYYTAVRAYNSAGAGP 889
Query: 959 PSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYGRND 1016
S V T++ P DT + ++W++ +E +TGY++ + +N+
Sbjct: 890 FSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNN 949
Query: 1017 SRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNL 1076
++ +T N T+ E L Y I+V A T G G +S I + S
Sbjct: 950 VQVLNT-NKTSAELV---LPIKEDYIIEVKATTDGGDG-TSSEQIRIPRITSMDARGSTS 1004
Query: 1077 VISNISPRSA 1086
ISN+ P S+
Sbjct: 1005 AISNVHPMSS 1014
Score = 151 bits (381), Expect = 8e-36
Identities = 107/371 (28%), Positives = 170/371 (45%), Gaps = 28/371 (7%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP + V E+T + +L W G D SP+ +++Q R WQT ++
Sbjct: 595 RGSPGPPENVKVD--EITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEV 652
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I + V L P+ Y+ R+ A+N IG + S +E V T + VP PP V+
Sbjct: 653 IDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGG 712
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
+ S ++I W P +E NG GY + +R L G T +T+ +T+ +
Sbjct: 713 SRSELVITWDPVPEELQNGEGFGYVVAFRPL----GVTTWIQTV---------VTSPDTP 759
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
+ V + + + Y YEV + YN GE P S VF E P +AP V
Sbjct: 760 RYVFRNES--------IVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSA 811
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
L++S++EV+W+ P + NG++ GY++ YW + E+ + E RL+ L S
Sbjct: 812 NSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKS 871
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAA-- 1828
+ Y ++ A+N+AG GP S T + P P T T + ++W + A
Sbjct: 872 NLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMEN 931
Query: 1829 NGILQGYRVVY 1839
+ GY+V Y
Sbjct: 932 ESEVTGYKVFY 942
Score = 137 bits (346), Expect = 9e-32
Identities = 115/423 (27%), Positives = 193/423 (45%), Gaps = 16/423 (3%)
Query: 1048 VTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEG 1107
V V TG+ + S+ + + PG P N+ + I+ +A L ++ G D + + + ++
Sbjct: 576 VCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQA 635
Query: 1108 QVG-AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVI 1166
+ ++G + VT E + + L P+ Y FR+ N +G S S +
Sbjct: 636 RTPFSVGWQT--VTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKV 693
Query: 1167 QTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVA 1226
+T +A P+V P+ V S + L + W P+P+ NG E GY + + + +
Sbjct: 694 RTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNG--EGFGYVVAFRPLGVTTWIQT 751
Query: 1227 QVVSDRLERE-FTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSA 1285
V S R F E + + YE+++ +N G GP+S V + E P+ AP VSA
Sbjct: 752 VVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSA 811
Query: 1286 EAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHI-VRGNHTQSALLAGLR 1344
++SS++I ++W ++P + NG +LGY++ + E S + V GN T SA L GL+
Sbjct: 812 NSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNET-SARLRGLK 870
Query: 1345 KFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPE-- 1402
+ Y V A+ G G P + + TK P P V T V + W+ +
Sbjct: 871 SNLAYYTAVRAYNSAGAG-PFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAM 929
Query: 1403 EPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462
E + GY++ YR +S + V+V T + L + YI + A T G G
Sbjct: 930 ENESEVTGYKVFYRTSSQN-----NVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGT 984
Query: 1463 PLE 1465
E
Sbjct: 985 SSE 987
Score = 111 bits (277), Expect = 9e-24
Identities = 111/440 (25%), Positives = 176/440 (40%), Gaps = 38/440 (8%)
Query: 1359 IGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLA 1418
+ GV S + +PGPP + E+ T+ ++ W+ ++ + ++ Y I R
Sbjct: 579 VQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTP 638
Query: 1419 SSSP-HTFTTVEVGATVRQFTAT--DLAPESAYIFRLSAKTRQGWGEP-LEATVITTEKR 1474
S T TTV + TAT +L P Y FR+ A + G GEP L + + TE+
Sbjct: 639 FSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEA 698
Query: 1475 ERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHE 1534
PP E V + L + W P + F V P G + ++
Sbjct: 699 VPEVPPSE--VNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSP 756
Query: 1535 ATACVVDR---LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHT 1591
T V R + P++ Y++++ N+ G+ FS T V + ++ P P VSA +
Sbjct: 757 DTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVT-TVFSAEEEPTVAPSQVSANSLS 815
Query: 1592 TSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFK 1651
+S + + W + NG L GY E+ Y G G E + K +A
Sbjct: 816 SSEIEVSWNTIPWKLSNGHLLGY-----EVRYWNGGGKEESSSKMKVA------------ 858
Query: 1652 TVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVT 1711
T L LK Y + AYN G P SA V V + P+ P NV V
Sbjct: 859 -----GNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNV-VW 912
Query: 1712 PLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSH 1771
T +++ + W+ + GYK++Y SQN + + +V L
Sbjct: 913 NATDTKVLLNWEQVKAMENESEVTGYKVFY-RTSSQNNVQVLNTNKTSAELV----LPIK 967
Query: 1772 TKYLVSISAFNAAGDGPKSD 1791
Y++ + A GDG S+
Sbjct: 968 EDYIIEVKATTDGGDGTSSE 987
Score = 79.3 bits (194), Expect = 4e-14
Identities = 77/295 (26%), Positives = 129/295 (43%), Gaps = 14/295 (4%)
Query: 1658 TSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVE-VFVGEAAPAMAPQNVQVTPLTAS 1716
T+T+ EL + YE + A N IG S P E V EA P + P V + S
Sbjct: 659 TATVVELN---PWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRS 715
Query: 1717 QLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVL-FLPEPVVRLKNLTSHTKYL 1775
+L +TWDP P E QNG GY + + + + P V R +++ ++ Y
Sbjct: 716 ELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYE 775
Query: 1776 VSISAFNAAGDGPKSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGEP--AAANGIL 1832
V + +N G+GP S + + P APS ++ + ++S+ + VSW +NG L
Sbjct: 776 VKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHL 835
Query: 1833 QGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQA 1892
GY V Y + S ++V GN + ++R L + Y+ V+A A
Sbjct: 836 LGYEVRYWNGGGKEESSS--KMKVAGN-ETSARLRGLKSNLAYYTAVRAYNSAGAGPFSA 892
Query: 1893 NITAGPAEGSPGS-PRDVLVTKSASELTLQW--TEGHSGDTPTTGYVIEARPSDE 1944
+ + P P +V+ + +++ L W + ++ TGY + R S +
Sbjct: 893 TVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQ 947
Score = 60.5 bits (145), Expect = 2e-08
Identities = 39/106 (36%), Positives = 53/106 (50%), Gaps = 4/106 (3%)
Query: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPR--S 1957
GSPG P +V V + + + L W EG +P Y I+AR W V +P
Sbjct: 596 GSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQT-VTTVPEVID 654
Query: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
++T ++ +L V YEFRVVA N+ G GEPS PS V + P
Sbjct: 655 GKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVP 700
Score = 45.8 bits (107), Expect = 5e-04
Identities = 54/217 (24%), Positives = 74/217 (34%), Gaps = 21/217 (9%)
Query: 1799 QAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRG 1858
+ +PG P + EIT TT +SW E + + Y + V + EV
Sbjct: 595 RGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVID 654
Query: 1859 NWQRWLKVRDLTKGVTYFFRVQARTITYG------------PELQANITAGPAEGSPGSP 1906
V +L V Y FRV A G E + G GS
Sbjct: 655 GKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSR 714
Query: 1907 RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLD 1966
++++T LQ EG GYV+ RP W V P Y +
Sbjct: 715 SELVITWDPVPEELQNGEGF-------GYVVAFRPLGVTTWIQTVVTSP-DTPRYVFRNE 766
Query: 1967 KLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
+ YE +V N G G P +P T V + E P
Sbjct: 767 SIVPYSPYEVKVGVYNNKGEG-PFSPVTTVFSAEEEP 802
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 294 bits (752), Expect = 7e-79
Identities = 280/1058 (26%), Positives = 447/1058 (42%), Gaps = 96/1058 (9%)
Query: 98 AQDDVAPYFKTEPG---LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKY 154
+Q P F+ +P P+ E +++L C A S P ++W + +E+
Sbjct: 31 SQTTFGPVFEDQPLSVLFPEESTE-EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQ 89
Query: 155 IIPS-------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVS--QG 205
++ + DAG Y+C+ N +G ++ R++ ++ ++ F ++R V +G
Sbjct: 90 LVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEF-SKEERDPVKAHEG 148
Query: 206 RAAILNLLPITSYPRPQVTWF-REGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQ 262
+L P YP W E IP++ L I T SD G Y
Sbjct: 149 WGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
Query: 263 AVNEKNGENKT--SPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320
A + + K+ S F L++A + AP+I + + TLEC A
Sbjct: 209 ATSHMDFSTKSVFSKFAQLNLAAE--DTRLFAPSIKARFPAETYALVGQQVTLECFAFGN 266
Query: 321 PVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFL 380
PV + W++ ++ + L I + + D G Y CEA R T
Sbjct: 267 PVP--RIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAEN-----SKGRDTVQG 319
Query: 381 FIIEPPYFTAEPE-----SRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY 435
II A+PE S A++ + GC A G P PT++W ++ ++ QN R
Sbjct: 320 RII----VQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS-QN-RV 373
Query: 436 KVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTV--TD 493
+VLA G LR KL EDSG++QC A N+ G I L V +AP F PV +
Sbjct: 374 EVLA-GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAAR 432
Query: 494 GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTC 553
G ++ C+ APK + W + IL + S R + G L I + D G YTC
Sbjct: 433 GGEILIPCQPRAAPKAVVLWSKGTEILVNSS----RVTVTPDGTLIIRNISRSDEGKYTC 488
Query: 554 YAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDN 613
+A N G N++ L+V + T I P + G TL C A+HDP + L + W D+
Sbjct: 489 FAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDD 548
Query: 614 VAL---TPSSTSR--IVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP 668
+ P R V E G L I G Y+C + + S+ A + V P
Sbjct: 549 FPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP 608
Query: 669 HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVEL-SENNSPWK---VHLSNVGPE 724
P ++V + LSW R FD +SPI Y ++ + WK + +N+
Sbjct: 609 GPPGGVVV--RDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGN 666
Query: 725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQS 784
V GLTP Y+FRV A N +G G+ S +S++ E PS P + G
Sbjct: 667 AETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGE 726
Query: 785 IMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII--WTQYE 842
++V W P NG GY+L +R G +Q + + Y + ++ + +T +E
Sbjct: 727 LIVNWTPMSREYQNGDGFGYLLSFRRQG-STHWQTARVPGADAQYFVYSNESVRPYTPFE 785
Query: 843 IQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGIN 902
+++ +YN G G S Y+ + P P V + V+S+ + W P QQ +NGI
Sbjct: 786 VKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGIL 844
Query: 903 QGYKLLAWPADAPEAVT--VVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960
GY++ W A EA V T D ++ L T Y +V + G GP S
Sbjct: 845 LGYEIRYWKAGDKEAAADRVRTAGLD----TSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
Query: 961 TPQLVWTQEDKP-GAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYGRNDS 1017
T + P G++S+T +SL + W P +TGY++ ++ ND
Sbjct: 901 PSANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLYQ----NDL 955
Query: 1018 RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLV---TSSTISSGVPPD---LPG 1071
LT TL+ T + I++ +G LV T+ G+P + +
Sbjct: 956 HLTPTLHLTGKNW------------IEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRN 1003
Query: 1072 APSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQV 1109
+++++ N++ R A PG S++ I+ G +
Sbjct: 1004 GGTSMMVENMAVRPAP---HPGTVISHSVAMLILIGSL 1038
Score = 142 bits (359), Expect = 3e-33
Identities = 103/382 (26%), Positives = 178/382 (46%), Gaps = 34/382 (8%)
Query: 1465 EATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEW 1524
EATV+ R P PP ++V ++ +++L W G D SPI +T+Q R P G+W
Sbjct: 599 EATVLV---RGPPGPPGGVVV--RDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKW 653
Query: 1525 Q---TYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581
+ T ++I A V L P+ Y+ R+ A+N +G + S + + T + P
Sbjct: 654 KQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVA 713
Query: 1582 PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALH 1641
P +S +++ W P E NG GY + +R T +T + P
Sbjct: 714 PSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQ-----GSTHWQTARVP---- 764
Query: 1642 AELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAP 1701
A + + ++ S ++ Y +EV + +YN G+ P S V+ E P
Sbjct: 765 ---GADAQYFVYSNES---------VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEP 812
Query: 1702 AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEA-DSQNETEKMKVLFLPE 1760
+AP V +++S++ VTW+ P + NG + GY+I YW+A D + ++++ L +
Sbjct: 813 RVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGL-D 870
Query: 1761 PVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNV 1820
R+ L +TKY V++ A+N AG GP S T + P P +S++L++
Sbjct: 871 TSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSI 930
Query: 1821 SWGE--PAAANGILQGYRVVYE 1840
W P + GY+++Y+
Sbjct: 931 KWDPVVPFRNESAVTGYKMLYQ 952
Score = 129 bits (323), Expect = 4e-29
Identities = 97/351 (27%), Positives = 168/351 (47%), Gaps = 10/351 (2%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
PG P +V+ +I + L + G+D + I+++ ++ + G ++ V E +
Sbjct: 608 PGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQ-VRTNPANIEGN 666
Query: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
A+ ++ LTP+ Y FR+ NI+G S S I+T +A P VAP+ ++ +
Sbjct: 667 AETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGE 726
Query: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVV-SDRLEREFTIEELEEWMEY 1248
L + W P+ NG + GY + + R A+V +D ++ E + + +
Sbjct: 727 LIVNWTPMSREYQNG--DGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPF 784
Query: 1249 ELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGL 1308
E++++++N G GP S + E P AP V A+ VSS+++ +TW V +QD NG+
Sbjct: 785 EVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPV-QQDMNGI 843
Query: 1309 ILGYKILFRAKDLDPEPRSHIVR-GNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTP 1367
+LGY+I + K D E + VR SA ++GL Y + V A+ R G G P++P
Sbjct: 844 LLGYEIRY-WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG-PASP 901
Query: 1368 LILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYR 1416
T P P + +S+ I W P P + GY++ Y+
Sbjct: 902 SANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
Score = 97.1 bits (240), Expect = 2e-19
Identities = 86/366 (23%), Positives = 153/366 (41%), Gaps = 50/366 (13%)
Query: 1160 SPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS---------QYNGNPESVG 1210
S S ++ PP P V VR +T+++L W D+ Q P
Sbjct: 595 SASKEATVLVRGPPG-PPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKW 653
Query: 1211 YRIKYWRSDLQSSA-VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVR 1268
+++ ++++ +A AQV+ L WM+YE ++ A N +G G P +
Sbjct: 654 KQVRTNPANIEGNAETAQVLG-----------LTPWMDYEFRVIASNILGTGEPSGPSSK 702
Query: 1269 GRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSH 1328
RTRE+ PS AP +S + ++++ WT + + QNG GY + FR +
Sbjct: 703 IRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQG-------- 754
Query: 1329 IVRGNHTQSALLAG------------LRKFVLYELQVLAFTRIGNGVPSTPLILERTKDD 1376
H Q+A + G +R + +E+++ ++ R G+G S ++ +++
Sbjct: 755 ---STHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE 811
Query: 1377 APGPPVRLVFPEVRLTSVRIVWQPPEEP-NGIILGYQIAYRLASSSPHTFTTVEVGATVR 1435
P ++ V + + + W+P ++ NGI+LGY+I Y A V
Sbjct: 812 PRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDT 871
Query: 1436 QFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
+ L P + Y + A R G G + TT K PP + ++ SL
Sbjct: 872 SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNI---SWTFSSSSL 928
Query: 1496 RLQWVP 1501
++W P
Sbjct: 929 SIKWDP 934
Score = 57.0 bits (136), Expect = 2e-07
Identities = 38/130 (29%), Positives = 59/130 (45%), Gaps = 7/130 (5%)
Query: 1877 FRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSA-SELTLQWTEGHSGDTPTTGY 1935
+ A+T+ +A + G PG P V+V + + L W+ G +P Y
Sbjct: 585 YTCMAQTVVDSASKEATVLV---RGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKY 641
Query: 1936 VIEARPSDEGLWDMFVKDIPRS--ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993
++AR G W V+ P + + T + L + YEFRV+A N G GEPS PS
Sbjct: 642 TLQARTPPAGKWKQ-VRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPS 700
Query: 1994 TAVSAQVEAP 2003
+ + + AP
Sbjct: 701 SKIRTREAAP 710
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 291 bits (746), Expect = 4e-78
Identities = 322/1152 (27%), Positives = 495/1152 (42%), Gaps = 132/1152 (11%)
Query: 385 PPYFTAEP--ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVL---- 438
PP FT P ++ +S V + CQA G P P + W K +S N R++V+
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFI---CQATGDPRPKIVWNKKGKKVS---NQRFEVIEFDD 76
Query: 439 ASGG-LRIQKLR-PEDSGIFQCFASNEGGEIQTHTYLDVTNIA------PVFTQRPVDTT 490
SG LRIQ LR P D I++C ASN GEI T L V P P
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 491 VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGN 550
V TA + C SG P P ITW ++ + S R L SG LQI D G
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKD-FLPVDTSNNNGRIKQLRSGALQIEQSEESDQGK 195
Query: 551 YTCYAANTEGSLNASATLTVWNRTSIVHP-----PEDHVVIKGTTATLHCGATHDPRVSL 605
Y C A N+ G+ SA ++ R V P P +H ++ G + + C A P +
Sbjct: 196 YECVATNSAGT-RYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV 254
Query: 606 RYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVI 665
+++ ++ LTP I G ++ +Y+C +S G +A++ V
Sbjct: 255 KWMLGAED--LTPEDDMPI-----GRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVK 307
Query: 666 ELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGN-SPILYYIVELSENNSPWKVHLSNVGPE 724
LP P +V+ +++ S + L+W GN P+ YYI++ NS +++ G
Sbjct: 308 ALPKPPGTPVVTESTATS--ITLTWD---SGNPEPVSYYIIQHKPKNSE-ELYKEIDGVA 361
Query: 725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQS 784
T +V+GL+P Y+FRV AVN +GRG S E E+ PS+ P+++ A ++ +
Sbjct: 362 TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQTSEQAPSSAPRDVQARMLSSTT 420
Query: 785 IMVQWQPPPETEHNGVLRGYILRYRLAGLP--GEYQQRNITSPEVNYCLVTDLIIWTQYE 842
I+VQW+ P E NG ++GY + Y + + + N+ ++ + +L+ Y
Sbjct: 421 ILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLVPQKTYS 476
Query: 843 IQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGIN 902
++V A+ G G S + T GVP P N + E + T+I W PP I
Sbjct: 477 VKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTI---- 531
Query: 903 QGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTP 962
Y+L+ + E +TI P G + + LK + Y+ + + G G +
Sbjct: 532 ANYELVYKDGEHGEEQR-ITIEP---GTSY-RLQGLKPNSLYYFRLAARSPQGLGASTAE 586
Query: 963 QLVWTQEDKPGAVGH-LSFTEILDTSLKVSWQ-EPLEK-NGIITGYQISWEVYGRNDSRL 1019
T + KP A +S T TS+ VSWQ P+EK NGIIT Y I + D +
Sbjct: 587 ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP 646
Query: 1020 THTLN--STTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP-GAPSNL 1076
L S T +Y ++ L T Y I V A T VG G S ++ D+P G P +
Sbjct: 647 HEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTNEDVPSGPPRKV 705
Query: 1077 VISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQ-MLE- 1134
+ ++ S + +R K GQ+ G + +V + E EP Q ML+
Sbjct: 706 EVEAVNSTSVKVSWRSPVPNKQ-------HGQIR--GYQVHYVRM--ENGEPKGQPMLKD 754
Query: 1135 -------------------IPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDV 1175
I L P T Y + G S +++ T A P
Sbjct: 755 VMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS-KPKLVSTTGAVPG- 812
Query: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235
P V T T+L ++W P D+ GYR+K+ R D++ + E
Sbjct: 813 KPRLVINHTQMNTAL-IQWHPPVDT----FGPLQGYRLKFGRKDMEPLTTLEF--SEKED 865
Query: 1236 EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENVSAEAVSSTQIL 1294
FT ++ + Y ++ A N VG G E+V+ E VP+ P+N+ +E +ST +
Sbjct: 866 HFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQ 923
Query: 1295 LTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVL 1354
L+W ++NG+I Y +L+R ++ P ++ T + L GL+ Y+++V
Sbjct: 924 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVR 982
Query: 1355 AFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE------VRLTSVRIVWQPPEEPNGII 1408
A T G G P +P + RT PV VF + V TSV + W+ PE N
Sbjct: 983 AHTSKGPG-PYSPSVQFRTL------PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNS-A 1034
Query: 1409 LGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATV 1468
+ ++I Y EV Q +L PE +Y F L+ + G T
Sbjct: 1035 MPFKILYDDGK------MVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTA 1088
Query: 1469 ITTEK--RERPA 1478
T R +PA
Sbjct: 1089 KTAPDVLRTKPA 1100
Score = 221 bits (564), Expect = 5e-57
Identities = 273/1105 (24%), Positives = 447/1105 (40%), Gaps = 154/1105 (13%)
Query: 568 LTVWNRTSIVHPPE------DHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSST 621
LT + RT PP D + G A+ C AT DPR + VW K + S+
Sbjct: 12 LTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKI--VWNKKGKKV--SNQ 67
Query: 622 SRIVVEKD---GSLLISQTWSG--DIGDYSCEIVSEGGNDSRMARLEVI---ELPHSPQN 673
V+E D GS+L Q D Y C + G S RL V+ ++P
Sbjct: 68 RFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPT 127
Query: 674 LLVSPN---------------SSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHL 718
+ + P +S + ++W + F V+ S NN K
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDF--------LPVDTSNNNGRIKQLR 179
Query: 719 SNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP---SAPPKN- 774
S + + + ++ A N G +YSA + + P S PP N
Sbjct: 180 SGA------LQIEQSEESDQGKYECVATNSAGT-RYSAPANLYVRVRRVPPRFSIPPTNH 232
Query: 775 -IVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVT 833
I+ G N + + P P +++ L +PE + +
Sbjct: 233 EIMPGGSVNITCVAVGSPMP-----------YVKWMLGA--------EDLTPEDDMPIGR 273
Query: 834 DLIIWTQYEIQVAAYNGAGLGVFS--RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW- 890
+++ Q A Y + A+ + T++ +P P V TE+ +T+I W
Sbjct: 274 NVLELNDVR-QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST-ATSITLTWD 331
Query: 891 --NPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSV 948
NP P + Y + P ++ E + D + L ++ Y V
Sbjct: 332 SGNPEPVSY-------YIIQHKPKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRV 380
Query: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKNGIITGYQI 1007
+ G GPPS P L T E P + +L T++ V W+EP E NG I GY++
Sbjct: 381 VAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV 440
Query: 1008 -----------SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLV 1056
+W + DS++T I L TY++ V A T++G G +
Sbjct: 441 YYTMDPTQHVNNWMKHNVADSQIT----------TIGNLVPQKTYSVKVLAFTSIGDGPL 490
Query: 1057 TSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEE 1116
SS I +PG P N S S L + P +I+ + + + G G+E+
Sbjct: 491 -SSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--PRSDTIANYELVYKDGEHGEEQ 547
Query: 1117 EWVTLYEEENEPDAQMLEIPNLTPYTHYRFRM--KQVNIVGPSPYSPSSRVIQTLQAPPD 1174
+T+ EP + L P + Y FR+ + +G S S+R T+Q+ P
Sbjct: 548 R-ITI-----EPGTSY-RLQGLKPNSLYYFRLAARSPQGLGASTAEISAR---TMQSKPS 597
Query: 1175 VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLE 1234
P ++ + S TS+ + W P P + NG Y IKY D + +++ +
Sbjct: 598 APPQDISCTSPSSTSILVSWQPPPVEKQNGIITE--YSIKYTAVDGEDDKPHEILGIPSD 655
Query: 1235 R-EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQI 1293
++ +E+LE+W EY + + A VG GP S V RT E VPS P V EAV+ST +
Sbjct: 656 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 715
Query: 1294 LLTWTSVPEQDQNGLILGYKILF-RAKDLDPEPRSHI-----------VRGNHTQSALLA 1341
++W S Q+G I GY++ + R ++ +P+ + + +++
Sbjct: 716 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIIS 775
Query: 1342 GLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP 1401
GL+ Y L V A+T G+G S P ++ T PG P RLV ++ + I W PP
Sbjct: 776 GLQPETSYSLTVTAYTTKGDGARSKPKLVS-TTGAVPGKP-RLVINHTQMNTALIQWHPP 833
Query: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
+ G + GY++ + P TT+E FTATD+ ++Y+FRLSA+ + G+G
Sbjct: 834 VDTFGPLQGYRLKFGRKDMEP--LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 891
Query: 1462 EPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPG--SDGASPIRYFTMQVREL 1519
E + + E+ P + T+ S++L W P ++ I +T+ R++
Sbjct: 892 EEMVKEISIPEEVPTGFPQN---LHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI 948
Query: 1520 PRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG 1579
I T + L+P T+Y ++++A G +S + T D
Sbjct: 949 -NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1007
Query: 1580 EPPGSVSATPHTTSSVLIQWQPPRD 1604
V A T SVL+ W+ P +
Sbjct: 1008 AKNFHVKAVMKT--SVLLSWEIPEN 1030
Score = 210 bits (534), Expect = 1e-53
Identities = 204/781 (26%), Positives = 341/781 (43%), Gaps = 81/781 (10%)
Query: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
E + T +++P V E+ ++T I LTW S + + I+ +K +++L E
Sbjct: 299 EAIAQITVKALPKPPGTPVVTES-TATSITLTWDSGNPEPVSYYIIQHKPK-NSEELYKE 356
Query: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
+ G T +AGL + YE +V+A IG G PS P +L +T + AP R
Sbjct: 357 -----IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP-VLTQTSEQAPSSAPRD 410
Query: 1385 VFPEV-RLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT-DL 1442
V + T++ + W+ PEEPNG I GY++ Y + + H ++ Q T +L
Sbjct: 411 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM-DPTQHVNNWMKHNVADSQITTIGNL 469
Query: 1443 APESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLV-PQAEVTARSLRLQWVP 1501
P+ Y ++ A T G G PL + + + P P P++E S+ L W P
Sbjct: 470 VPQKTYSVKVLAFTSIGDG-PLSSDIQVITQTGVPGQPLNFKAEPESET---SILLSWTP 525
Query: 1502 GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGD 1561
+ I + + ++ GE Q + T+ + L+P + Y RL A + G
Sbjct: 526 PR--SDTIANYELVYKDGEHGEEQRITIE---PGTSYRLQGLKPNSLYYFRLAARSPQGL 580
Query: 1562 SDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYREL 1621
++E A T+Q P PP +S T +++S+L+ WQPP E NG++ Y I Y +
Sbjct: 581 GASTAEISA-RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAV 639
Query: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
+ E E + S +T L L+K+ Y + +TA+
Sbjct: 640 DGEDDKPHEI---------------------LGIPSDTTKYLLEQLEKWTEYRITVTAHT 678
Query: 1682 IIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY 1741
+G P S V + E P+ P+ V+V + ++ ++V+W P P Q+G I+GY+++Y
Sbjct: 679 DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 738
Query: 1742 --WEADSQNETEKMKVLFLPEPVVRLKNLTSH----------TKYLVSISAFNAAGDGPK 1789
E +K + L + + T H T Y ++++A+ GDG +
Sbjct: 739 VRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 798
Query: 1790 SDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVY-----EPLAP 1844
S P+ T A PG P L + T + W P G LQGYR+ + EPL
Sbjct: 799 SKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT 857
Query: 1845 VQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITYGPELQANITAGPAEGSP 1903
++ K + D+ KG +Y FR+ AR + +G E+ I+ P E
Sbjct: 858 LEFSEK----------EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI-PEEVPT 906
Query: 1904 GSPRDVL---VTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960
G P+++ T ++ +L+ Q + T Y + R + L M +P
Sbjct: 907 GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-- 964
Query: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAV-SAQVEAPFYEEWWFLLVMALSSL 2019
T++L L+ TY+ +V A G G P +PS + V+ F + + VM S L
Sbjct: 965 -TMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVL 1022
Query: 2020 I 2020
+
Sbjct: 1023 L 1023
Score = 202 bits (514), Expect = 3e-51
Identities = 259/1058 (24%), Positives = 431/1058 (40%), Gaps = 126/1058 (11%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGEN 271
T PRP++ W ++G K+ I ++ L I T A Y + GE
Sbjct: 48 TGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEI 107
Query: 272 KTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
S L++ R+ P PTI + P VV + T+ C AS P D +TW +
Sbjct: 108 SVST--RLTVLREDQIPRGF-PTIDMGP-QLKVVERTRTATMLCAASGNP--DPEITWFK 161
Query: 332 NGVRITSGLHSFGR-------RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIE 384
+ + + + ++ GR L I +D G Y C A A A ++ +
Sbjct: 162 DFLPVDTSNNN-GRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRR 220
Query: 385 -PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGL 443
PP F+ P + +V+I C A+G P+P ++W A ++ + + L
Sbjct: 221 VPPRFSIPPTNH-EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDD---MPIGRNVL 276
Query: 444 RIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEV 503
+ +R S + C A + G I+ + V + P PV T T T+I
Sbjct: 277 ELNDVR--QSANYTCVAMSTLGVIEAIAQITVKAL-PKPPGTPVVTEST--ATSITLTWD 331
Query: 504 SGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCY-----AANT 558
SG P+P ++ + + + E G+ + Y+ Y A N
Sbjct: 332 SGNPEPV------SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNN 385
Query: 559 EG-SLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGATHDPRVSLRYV------- 608
G + LT + + P D ++ TT + +P ++
Sbjct: 386 IGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD 445
Query: 609 -------WKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMAR 661
W K NVA + +T G+L+ +T+S + ++ + +G S +
Sbjct: 446 PTQHVNNWMKHNVADSQITTI-------GNLVPQKTYSVKVLAFTS--IGDGPLSSDIQV 496
Query: 662 LEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNV 721
+ +P P N P S S ++LSW P + + E+ ++ +
Sbjct: 497 ITQTGVPGQPLNFKAEPESETS--ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE-- 552
Query: 722 GPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRT 781
T + GL P Y FR+ A + G G +AE S + + PSAPP++I + +
Sbjct: 553 --PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM-QSKPSAPPQDISCTSPS 609
Query: 782 NQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE----YQQRNITSPEVNYCLVTDLII 837
+ SI+V WQPPP + NG++ Y ++Y + GE ++ I S Y L+ L
Sbjct: 610 STSILVSWQPPPVEKQNGIITEYSIKY--TAVDGEDDKPHEILGIPSDTTKY-LLEQLEK 666
Query: 838 WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQF 897
WT+Y I V A+ G G S +V T + VP+ PP+ V+ EAVNST+++ W P
Sbjct: 667 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 726
Query: 898 INGINQGYKL------LAWPADAPEAVTVVTIAP----DFHGVHHGHITNLKKFTAYFTS 947
+G +GY++ P P V+ D H I+ L+ T+Y +
Sbjct: 727 QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 786
Query: 948 VLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQI 1007
V +TT GDG S P+LV T PG + ++T+L + W P++ G + GY++
Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRL 845
Query: 1008 SWEVYGRNDSRLTHTLNSTTHE--YKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGV 1065
+GR D TL + E + + +Y ++A VG G IS +
Sbjct: 846 K---FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEIS--I 900
Query: 1066 PPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEE 1124
P ++P G P NL + S L ++P ++ + G I ++ LY +
Sbjct: 901 PEEVPTGFPQNLHSEGTTSTSVQLSWQPP----------VLAERNGII---TKYTLLYRD 947
Query: 1125 ENEPDAQM----------LEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPD 1174
N P M + + L P T Y +++ GP PYSPS +Q P D
Sbjct: 948 INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPS---VQFRTLPVD 1004
Query: 1175 -VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGY 1211
V + V+ +TS+ L W +P++ + P + Y
Sbjct: 1005 QVFAKNFHVKAVMKTSVLLSW-EIPENYNSAMPFKILY 1041
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 290 bits (742), Expect = 1e-77
Identities = 280/1012 (27%), Positives = 445/1012 (43%), Gaps = 74/1012 (7%)
Query: 84 WALLALQLHLLRALAQDDVA--PYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWM 139
W L+ L L L+ + A D + P F EP + + L + ++L C A G ++W
Sbjct: 5 WKLVIL-LPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWK 63
Query: 140 RDDSELT-TYSSEYKYIIPSLQ------KLDAGFYRCVVRNRMGALLQRKSEVQVAYMGS 192
++ +++ T S Y+ SL D G Y+C+ N +G +L RK+++Q AY+
Sbjct: 64 QNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIED 123
Query: 193 FMDTDQRKTVS--QGRAAILNLLPITSYPRPQVTWFREGHKII--PSNRIAITLEN-QLV 247
F +T R TVS +G+ +L P + W + + NR ++ E L
Sbjct: 124 F-ETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLY 182
Query: 248 ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAG 307
I SD G Y N++ + P L + R G P I V A
Sbjct: 183 IAKVEPSDVGNYTCFITNKEAQRSVQGPPTPL-VQRTDGVMGEYEPKIEVRFPETIQAAK 241
Query: 308 SSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRR---LTISNPTSADTGPYVCEA 364
S LEC A PV D+S W+R G + + L I N D G Y C A
Sbjct: 242 DSSVKLECFALGNPVPDIS--WRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIA 299
Query: 365 A-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKD 423
+ L G A L PP + + ++ + + + C+A G P P W K+
Sbjct: 300 SNLRGRNL----AKGQLIFYAPPEWEQKIQNT-HLSIYDNLLWECKASGKPNPWYTWLKN 354
Query: 424 AISISRLQNPRYKV-LASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVF 482
+ NP ++ + +G L I L DSG++QC A N+ I + L V AP F
Sbjct: 355 GERL----NPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDF 410
Query: 483 TQRPVD--TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI 540
++ PV + V G ++ C+ + P+ AI+WKR L R LLE G L+I
Sbjct: 411 SKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSK----RIFLLEDGSLKI 466
Query: 541 APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
+ DAG+YTC A N G+ + +L V RT I PP V G + L C +HD
Sbjct: 467 YNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHD 526
Query: 601 PRVSLRYVW--KKDNVALTP--SSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGND 656
P + + +VW D + L + RI E G L+I G Y C + + +
Sbjct: 527 PSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESL 586
Query: 657 SRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKV 716
S +A + V P P+++ V SS + LSW D NSPI + + + +P+ V
Sbjct: 587 SAVADIIVRGPPGPPEDVQVEDISSTTSQ--LSWRAGPDNNSPIQIFTI---QTRTPFSV 641
Query: 717 HLSNVG--PEMT-----GVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPS 769
V PE+ TV GL+P Y+FRV A N +G G+ S + L P
Sbjct: 642 GWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPV 701
Query: 770 APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNY 829
P NI G + +++ W+ PE NG GYI+ +R G + + ++S E +
Sbjct: 702 VAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVG-STTWSKEKVSSVESSR 760
Query: 830 CLVTD--LIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQ 887
+ + +I + +E++V YN G G S Y+ + P P+ ++ +++ ++
Sbjct: 761 FVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEME 820
Query: 888 FLWNPPPQQFINGINQGYKLLAWPADAPEA-VTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
WN G GY++L W D+ E+ + + ++ + V +IT LK T YF
Sbjct: 821 VSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGN---VTTKNITGLKANTIYFA 877
Query: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQ--EPLEKNGIITG 1004
SV + T G GP S P V T++ P ++ ++ L ++W+ + +E + G
Sbjct: 878 SVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLG 937
Query: 1005 YQISWEVYGRNDSRLTHTL--NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG 1054
Y+I +Y +N TH L N+T+ E + Y I++ V+ G G
Sbjct: 938 YKI---LYRQNRQSKTHILETNNTSAELLVPFEED---YLIEIRTVSDGGDG 983
Score = 129 bits (324), Expect = 3e-29
Identities = 103/374 (27%), Positives = 167/374 (44%), Gaps = 34/374 (9%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQ---TYSSS 1530
R P PP ++ V ++++ + +L W G D SPI+ FT+Q R WQ T
Sbjct: 595 RGPPGPPEDVQVE--DISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEI 652
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
++ + V L P+ Y+ R+ A N IG + S +E + T VP P ++
Sbjct: 653 LNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGG 712
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
+ S ++I W+ +E NG GY I +R + GS T +K + + S F
Sbjct: 713 SRSELVITWESIPEELQNGEGFGYIIMFRPV----GSTTWSKEKVSSVE-------SSRF 761
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
N S + +EV + YN GE S V+ GE P +AP+ +
Sbjct: 762 VYRNES----------IIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSL 811
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLT- 1769
+AS++EV+W+ G + GY++ YW DS+ E M V KN+T
Sbjct: 812 QSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSK---ESMIGKIRVSGNVTTKNITG 868
Query: 1770 --SHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
++T Y S+ A+N AG GP S P T ++ P P ++T++ L ++W
Sbjct: 869 LKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKT 928
Query: 1828 ANGILQ--GYRVVY 1839
+ GY+++Y
Sbjct: 929 MENESEVLGYKILY 942
Score = 108 bits (271), Expect = 4e-23
Identities = 88/371 (23%), Positives = 164/371 (44%), Gaps = 11/371 (2%)
Query: 1051 VGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG 1110
V T L + S ++ + PG P ++ + +IS ++ L +R G D + I + ++ +
Sbjct: 579 VQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTP 638
Query: 1111 AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQ 1170
+ T+ E N + L+P+ Y FR+ N +G S S +++T
Sbjct: 639 FSVGWQAVATVPEILNGKTYNATVV-GLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKA 697
Query: 1171 APPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKY---WRSDLQSSAVAQ 1227
+ P VAP ++ S + L + W +P+ NG E GY I + + V+
Sbjct: 698 SVPVVAPVNIHGGGGSRSELVITWESIPEELQNG--EGFGYIIMFRPVGSTTWSKEKVSS 755
Query: 1228 VVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEA 1287
V S R + E + +E+++ +N G G S V + E P AP S ++
Sbjct: 756 VESSRFV--YRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQS 813
Query: 1288 VSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFV 1347
S++++ ++W ++ G +LGY++L+ D I + + + GL+
Sbjct: 814 FSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANT 873
Query: 1348 LYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPE--EPN 1405
+Y V A+ G G PS+P + TK P P + ++ + + + W+ + E
Sbjct: 874 IYFASVRAYNTAGTG-PSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENE 932
Query: 1406 GIILGYQIAYR 1416
+LGY+I YR
Sbjct: 933 SEVLGYKILYR 943
Score = 97.1 bits (240), Expect = 2e-19
Identities = 100/423 (23%), Positives = 164/423 (38%), Gaps = 39/423 (9%)
Query: 1163 SRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQ--------YNGNPESVGYRIK 1214
S V + P P V V S T+ +L W PD+ P SVG+
Sbjct: 587 SAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGW--- 643
Query: 1215 YWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRE 1273
Q+ A + + T+ L W+EYE ++ A N++G G SE RT+
Sbjct: 644 ------QAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKA 697
Query: 1274 SVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGN 1333
SVP AP N+ S +++++TW S+PE+ QNG GY I+FR + + +
Sbjct: 698 SVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKV---S 754
Query: 1334 HTQSALLAGLRKFVL----YELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEV 1389
+S+ + ++ +E++V + G G ST I+ +D+ P
Sbjct: 755 SVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSF 814
Query: 1390 RLTSVRIVWQPP--EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESA 1447
+ + + W G +LGY++ Y S + V V T L +
Sbjct: 815 SASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTI 874
Query: 1448 YIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW--VPGSDG 1505
Y + A G G +TT+K PP + ++T L L W V +
Sbjct: 875 YFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANI---AWKLTNSKLCLNWEHVKTMEN 931
Query: 1506 ASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPF-TSYKLRLKATNDIGDSDF 1564
S + + + R+ S + E + L PF Y + ++ +D GD
Sbjct: 932 ESEVLGYKILYRQ------NRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSS 985
Query: 1565 SSE 1567
S E
Sbjct: 986 SEE 988
Score = 83.2 bits (204), Expect = 3e-15
Identities = 95/372 (25%), Positives = 154/372 (41%), Gaps = 37/372 (9%)
Query: 1266 VVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILG------YKILFRAK 1319
+VRG P PE+V E +SST L+W + P+ + I + + ++A
Sbjct: 593 IVRG------PPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAV 646
Query: 1320 DLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379
PE + T +A + GL +V YE +V+A IG G PS P L RTK P
Sbjct: 647 ATVPE-----ILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPV 701
Query: 1380 -PPVRLVFPEVRLTSVRIVWQ--PPEEPNGIILGYQIAYRLASS---SPHTFTTVEVGAT 1433
PV + + + I W+ P E NG GY I +R S S ++VE
Sbjct: 702 VAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRF 761
Query: 1434 VRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPR-----ELLVPQA 1488
V + + P S + ++ +G G T++ + + E PR +
Sbjct: 762 V--YRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEM 819
Query: 1489 EVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTS 1548
EV+ ++ G + Y+T +E G+ + +S T + L+ T
Sbjct: 820 EVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIR-----VSGNVTTKNITGLKANTI 874
Query: 1549 YKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLN 1608
Y ++A N G SS VTT + P +PP ++ A T S + + W+ +
Sbjct: 875 YFASVRAYNTAGTGP-SSPPVNVTTKKSPPSQPPANI-AWKLTNSKLCLNWEHVKTMENE 932
Query: 1609 GLLQGYRIYYRE 1620
+ GY+I YR+
Sbjct: 933 SEVLGYKILYRQ 944
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/179 (29%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 1848 VSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTI--------------TYGPELQAN 1893
VS ++EV W V DL KGV +F R+ ++ Y +Q
Sbjct: 523 VSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTT 582
Query: 1894 ITAGPA------EGSPGSPRDVLVTKSASELT-LQWTEGHSGDTPTTGYVIEARPSDEGL 1946
+ + A G PG P DV V +S + L W G ++P + I+ R
Sbjct: 583 LESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVG 642
Query: 1947 WDMFVKDIPR--SATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
W V +P + +Y ++ L V YEFRVVA N G GEPS PS + + P
Sbjct: 643 WQA-VATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVP 700
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 290 bits (741), Expect = 1e-77
Identities = 322/1155 (27%), Positives = 495/1155 (42%), Gaps = 134/1155 (11%)
Query: 385 PPYFTAEP--ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVL---- 438
PP FT P ++ +S V + CQA G P P + W K +S N R++V+
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFI---CQATGDPRPKIVWNKKGKKVS---NQRFEVIEFDD 76
Query: 439 ASGG-LRIQKLR-PEDSGIFQCFASNEGGEIQTHTYLDVTNIA------PVFTQRPVDTT 490
SG LRIQ LR P D I++C ASN GEI T L V P P
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 491 VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLES---------GGLQIA 541
V TA + C SG P P ITW ++ + S R L S G LQI
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKD-FLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
Query: 542 PVFIQDAGNYTCYAANTEGS-LNASATLTVWNRTSIVH-------PPEDHVVIKGTTATL 593
D G Y C A N+ G+ +A A L V + PP +H ++ G + +
Sbjct: 196 QSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNI 255
Query: 594 HCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
C A P ++++ ++ LTP I G ++ +Y+C +S
Sbjct: 256 TCVAVGSPMPYVKWMLGAED--LTPEDDMPI-----GRNVLELNDVRQSANYTCVAMSTL 308
Query: 654 GNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGN-SPILYYIVELSENNS 712
G +A++ V LP P +V+ +++ S + L+W GN P+ YYI++ NS
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATS--ITLTWD---SGNPEPVSYYIIQHKPKNS 363
Query: 713 PWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPP 772
+++ G T +V+GL+P Y+FRV AVN +GRG S E E+ PS+ P
Sbjct: 364 E-ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQTSEQAPSSAP 421
Query: 773 KNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLP--GEYQQRNITSPEVNYC 830
+++ A ++ +I+VQW+ P E NG ++GY + Y + + + N+ ++
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-- 477
Query: 831 LVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW 890
+ +L+ Y ++V A+ G G S + T GVP P N + E + T+I W
Sbjct: 478 TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSW 536
Query: 891 NPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLC 950
PP I Y+L+ + E +TI P G + + LK + Y+ +
Sbjct: 537 TPPRSDTI----ANYELVYKDGEHGEEQR-ITIEP---GTSY-RLQGLKPNSLYYFRLAA 587
Query: 951 FTTPGDGPPSTPQLVWTQEDKPGAVGH-LSFTEILDTSLKVSWQ-EPLEK-NGIITGYQI 1007
+ G G + T + KP A +S T TS+ VSWQ P+EK NGIIT Y I
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 1008 SWEVYGRNDSRLTHTLN--STTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGV 1065
+ D + L S T +Y ++ L T Y I V A T VG G S ++
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRT 706
Query: 1066 PPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEE 1124
D+P G P + + ++ S + +R K GQ+ G + +V + E
Sbjct: 707 NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ-------HGQIR--GYQVHYVRM--E 755
Query: 1125 ENEP------------DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAP 1172
EP DAQ + I L P T Y + G S +++ T A
Sbjct: 756 NGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS-KPKLVSTTGAV 814
Query: 1173 PDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDR 1232
P P V T T+L ++W P D+ GYR+K+ R D++ +
Sbjct: 815 PG-KPRLVINHTQMNTAL-IQWHPPVDT----FGPLQGYRLKFGRKDMEPLTTLEF--SE 866
Query: 1233 LEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENVSAEAVSST 1291
E FT ++ + Y ++ A N VG G E+V+ E VP+ P+N+ +E +ST
Sbjct: 867 KEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTST 924
Query: 1292 QILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYEL 1351
+ L+W ++NG+I Y +L+R ++ P ++ T + L GL+ Y++
Sbjct: 925 SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDV 983
Query: 1352 QVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE------VRLTSVRIVWQPPEEPN 1405
+V A T G G P +P + RT PV VF + V TSV + W+ PE N
Sbjct: 984 KVRAHTSKGPG-PYSPSVQFRTL------PVDQVFAKNFHVKAVMKTSVLLSWEIPENYN 1036
Query: 1406 GIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLE 1465
+ ++I Y EV Q +L PE +Y F L+ + G
Sbjct: 1037 S-AMPFKILYDDGK------MVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHR 1089
Query: 1466 ATVITTEK--RERPA 1478
T T R +PA
Sbjct: 1090 VTAKTAPDVLRTKPA 1104
Score = 229 bits (584), Expect = 2e-59
Identities = 278/1096 (25%), Positives = 454/1096 (41%), Gaps = 132/1096 (12%)
Query: 568 LTVWNRTSIVHPPE------DHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSST 621
LT + RT PP D + G A+ C AT DPR + VW K + S+
Sbjct: 12 LTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKI--VWNKKGKKV--SNQ 67
Query: 622 SRIVVEKD---GSLLISQTWSG--DIGDYSCEIVSEGGNDSRMARLEVI---ELPHSPQN 673
V+E D GS+L Q D Y C + G S RL V+ ++P
Sbjct: 68 RFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPT 127
Query: 674 LLVSPN---------------SSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHL 718
+ + P +S + ++W + F V+ S NN K
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDF--------LPVDTSNNNGRIK--- 176
Query: 719 SNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVAS 778
++ ++ G TP R ++ E +G+Y + SAP V
Sbjct: 177 -----QLRSESIGG-TPIRG-ALQIEQSEESDQGKYECVATNSAGTRY--SAPANLYVRE 227
Query: 779 GRTNQSIMVQWQPPPETEHNGVLRGYI-LRYRLAGLPGEYQQRNI----TSPEVNYCLVT 833
R + + ++ PP T H + G + + G P Y + + +PE + +
Sbjct: 228 LREVRRVPPRFSIPP-TNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGR 286
Query: 834 DLIIWTQYEIQVAAYNGAGLGVFS--RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW- 890
+++ Q A Y + A+ + T++ +P P V TE+ +T+I W
Sbjct: 287 NVLELNDVR-QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST-ATSITLTWD 344
Query: 891 --NPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSV 948
NP P + Y + P ++ E + D + L ++ Y V
Sbjct: 345 SGNPEPVSY-------YIIQHKPKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRV 393
Query: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKNGIITGYQI 1007
+ G GPPS P L T E P + +L T++ V W+EP E NG I GY++
Sbjct: 394 VAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV 453
Query: 1008 -----------SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLV 1056
+W + DS++T I L TY++ V A T++G G +
Sbjct: 454 YYTMDPTQHVNNWMKHNVADSQIT----------TIGNLVPQKTYSVKVLAFTSIGDGPL 503
Query: 1057 TSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEE 1116
SS I +PG P N S S L + P +I+ + + + G G+E+
Sbjct: 504 -SSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--PRSDTIANYELVYKDGEHGEEQ 560
Query: 1117 EWVTLYEEENEPDAQMLEIPNLTPYTHYRFRM--KQVNIVGPSPYSPSSRVIQTLQAPPD 1174
+T+ EP + L P + Y FR+ + +G S S+R T+Q+ P
Sbjct: 561 R-ITI-----EPGTSY-RLQGLKPNSLYYFRLAARSPQGLGASTAEISAR---TMQSKPS 610
Query: 1175 VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLE 1234
P ++ + S TS+ + W P P + NG Y IKY D + +++ +
Sbjct: 611 APPQDISCTSPSSTSILVSWQPPPVEKQNGIITE--YSIKYTAVDGEDDKPHEILGIPSD 668
Query: 1235 R-EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQI 1293
++ +E+LE+W EY + + A VG GP S V RT E VPS P V EAV+ST +
Sbjct: 669 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 728
Query: 1294 LLTWTSVPEQDQNGLILGYKILF-RAKDLDP--EPRSHIVRGNHTQSALLAGLRKFVLYE 1350
++W S Q+G I GY++ + R ++ +P +P V Q +++GL+ Y
Sbjct: 729 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYS 788
Query: 1351 LQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILG 1410
L V A+T G+G S P ++ T PG P RLV ++ + I W PP + G + G
Sbjct: 789 LTVTAYTTKGDGARSKPKLVS-TTGAVPGKP-RLVINHTQMNTALIQWHPPVDTFGPLQG 846
Query: 1411 YQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVIT 1470
Y++ + P TT+E FTATD+ ++Y+FRLSA+ + G+GE + +
Sbjct: 847 YRLKFGRKDMEP--LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 904
Query: 1471 TEKRERPAPPRELLVPQAEVTARSLRLQWVPG--SDGASPIRYFTMQVRELPRGEWQTYS 1528
E+ P + T+ S++L W P ++ I +T+ R++
Sbjct: 905 PEEVPTGFPQN---LHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI-NIPLLPME 960
Query: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSAT 1588
I T + L+P T+Y ++++A G +S + T D V A
Sbjct: 961 QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAV 1020
Query: 1589 PHTTSSVLIQWQPPRD 1604
T SVL+ W+ P +
Sbjct: 1021 MKT--SVLLSWEIPEN 1034
Score = 212 bits (539), Expect = 4e-54
Identities = 201/772 (26%), Positives = 341/772 (44%), Gaps = 72/772 (9%)
Query: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
E + T +++P V E+ ++T I LTW S + + I+ +K +++L E
Sbjct: 312 EAIAQITVKALPKPPGTPVVTES-TATSITLTWDSGNPEPVSYYIIQHKPK-NSEELYKE 369
Query: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
+ G T +AGL + YE +V+A IG G PS P +L +T + AP R
Sbjct: 370 -----IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP-VLTQTSEQAPSSAPRD 423
Query: 1385 VFPEV-RLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT-DL 1442
V + T++ + W+ PEEPNG I GY++ Y + + H ++ Q T +L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM-DPTQHVNNWMKHNVADSQITTIGNL 482
Query: 1443 APESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLV-PQAEVTARSLRLQWVP 1501
P+ Y ++ A T G G PL + + + P P P++E S+ L W P
Sbjct: 483 VPQKTYSVKVLAFTSIGDG-PLSSDIQVITQTGVPGQPLNFKAEPESET---SILLSWTP 538
Query: 1502 GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGD 1561
+ I + + ++ GE Q + T+ + L+P + Y RL A + G
Sbjct: 539 PR--SDTIANYELVYKDGEHGEEQRITIE---PGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 1562 SDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYREL 1621
++E A T+Q P PP +S T +++S+L+ WQPP E NG++ Y I Y +
Sbjct: 594 GASTAEISA-RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAV 652
Query: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
+ E E + S +T L L+K+ Y + +TA+
Sbjct: 653 DGEDDKPHEI---------------------LGIPSDTTKYLLEQLEKWTEYRITVTAHT 691
Query: 1682 IIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY 1741
+G P S V + E P+ P+ V+V + ++ ++V+W P P Q+G I+GY+++Y
Sbjct: 692 DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 751
Query: 1742 WEADS---QNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH 1798
++ + + V+ + + L T Y ++++A+ GDG +S P+ T
Sbjct: 752 VRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 811
Query: 1799 QAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVY-----EPLAPVQGVSKVVT 1853
A PG P L + T + W P G LQGYR+ + EPL ++ K
Sbjct: 812 GAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK--- 867
Query: 1854 VEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITYGPELQANITAGPAEGSPGSPRDVL-- 1910
+ D+ KG +Y FR+ AR + +G E+ I+ P E G P+++
Sbjct: 868 -------EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI-PEEVPTGFPQNLHSE 919
Query: 1911 -VTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLR 1969
T ++ +L+ Q + T Y + R + L M +P T++L L+
Sbjct: 920 GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT---TMTLTGLK 976
Query: 1970 QGVTYEFRVVAVNEAGYGEPSNPSTAV-SAQVEAPFYEEWWFLLVMALSSLI 2020
TY+ +V A G G P +PS + V+ F + + VM S L+
Sbjct: 977 PDTTYDVKVRAHTSKGPG-PYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLL 1027
Score = 197 bits (502), Expect = 7e-50
Identities = 265/1072 (24%), Positives = 437/1072 (40%), Gaps = 150/1072 (13%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLE------NQLVILATTTSDAGAYYVQAVNEKNG 269
T PRP++ W ++G K+ SN+ +E + L I T A Y + G
Sbjct: 48 TGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVG 105
Query: 270 ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW 329
E S L++ R+ P PTI + P VV + T+ C AS P D +TW
Sbjct: 106 EISVS--TRLTVLREDQIPRGF-PTIDMGP-QLKVVERTRTATMLCAASGNP--DPEITW 159
Query: 330 KRNGVRITSGLHSFGR----------------RLTISNPTSADTGPYVCEAALPGSAFEP 373
++ + + + ++ GR L I +D G Y C A SA
Sbjct: 160 FKDFLPVDTS-NNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVAT--NSAGTR 216
Query: 374 ARATAFLFIIE-------PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS 426
A A L++ E PP F+ P + +V+I C A+G P+P ++W A
Sbjct: 217 YSAPANLYVRELREVRRVPPRFSIPPTNH-EIMPGGSVNITCVAVGSPMPYVKWMLGAED 275
Query: 427 ISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRP 486
++ + + L + +R S + C A + G I+ + V + P P
Sbjct: 276 LTPEDD---MPIGRNVLELNDVR--QSANYTCVAMSTLGVIEAIAQITVKAL-PKPPGTP 329
Query: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ 546
V T T T+I SG P+P ++ + + + E G+ +
Sbjct: 330 VVTEST--ATSITLTWDSGNPEPV------SYYIIQHKPKNSEELYKEIDGVATTRYSVA 381
Query: 547 DAGNYTCY-----AANTEG-SLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGAT 598
Y+ Y A N G + LT + + P D ++ TT +
Sbjct: 382 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 441
Query: 599 HDPRVSLRYV--------------WKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGD 644
+P ++ W K NVA + +T G+L+ +T+S +
Sbjct: 442 EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI-------GNLVPQKTYSVKVLA 494
Query: 645 YSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYI 704
++ + +G S + + +P P N P S S ++LSW P +
Sbjct: 495 FTS--IGDGPLSSDIQVITQTGVPGQPLNFKAEPESETS--ILLSWTPPRSDTIANYELV 550
Query: 705 VELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLP 764
+ E+ ++ + T + GL P Y FR+ A + G G +AE S +
Sbjct: 551 YKDGEHGEEQRITIE----PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM- 605
Query: 765 EEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE----YQQR 820
+ PSAPP++I + ++ SI+V WQPPP + NG++ Y ++Y + GE ++
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY--TAVDGEDDKPHEIL 663
Query: 821 NITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEA 880
I S Y L+ L WT+Y I V A+ G G S +V T + VP+ PP+ V+ EA
Sbjct: 664 GIPSDTTKY-LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA 722
Query: 881 VNSTTIQFLWNPPPQQFINGINQGYKL------LAWPADAPEAVTVVTI-APDFHGVHHG 933
VNST+++ W P +G +GY++ P P V+ A D
Sbjct: 723 VNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDM------ 776
Query: 934 HITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQ 993
I+ L+ T+Y +V +TT GDG S P+LV T PG + ++T+L + W
Sbjct: 777 IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQWH 835
Query: 994 EPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHE--YKIQGLSSLTTYTIDVAAVTAV 1051
P++ G + GY++ +GR D TL + E + + +Y ++A V
Sbjct: 836 PPVDTFGPLQGYRLK---FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKV 892
Query: 1052 GTGLVTSSTISSGVPPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG 1110
G G IS +P ++P G P NL + S L ++P ++ + G
Sbjct: 893 GFGEEMVKEIS--IPEEVPTGFPQNLHSEGTTSTSVQLSWQPP----------VLAERNG 940
Query: 1111 AIGDEEEWVTLYEEENEPDAQM----------LEIPNLTPYTHYRFRMKQVNIVGPSPYS 1160
I ++ LY + N P M + + L P T Y +++ GP PYS
Sbjct: 941 II---TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS 997
Query: 1161 PSSRVIQTLQAPPD-VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGY 1211
PS +Q P D V + V+ +TS+ L W +P++ + P + Y
Sbjct: 998 PS---VQFRTLPVDQVFAKNFHVKAVMKTSVLLSW-EIPENYNSAMPFKILY 1045
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 289 bits (740), Expect = 2e-77
Identities = 320/1338 (23%), Positives = 537/1338 (40%), Gaps = 159/1338 (11%)
Query: 119 GNRLVLTCLAEGSWPLEFKWMR-------DDSELTTYSSEYKYIIPSLQKLDAGFYRCVV 171
G+ ++L+C GS +W R D++ S +I S QK +G Y+C
Sbjct: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
Query: 172 RNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILN-------LLPITSYPRPQVT 224
RK++ + ++ + VS ++N + P P VT
Sbjct: 449 T--------RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVT 500
Query: 225 WFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARD 284
W + I+ R NQ + TT + +N + + +
Sbjct: 501 WALDDEPIV---RDGSHRTNQYTMSDGTT-------ISHMNVTGPQIRDGGVYRCTARNL 550
Query: 285 VGTPETMA------PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITS 338
VG+ E A P + N + VAG +T + C P S+ W ++ + +
Sbjct: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGR-DTLINCRVIGYPY--YSIKWYKDALLLPD 607
Query: 339 GLHSFGRRLTISNPT--------SADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTA 390
R++ N T D G Y+C + + + + PP
Sbjct: 608 N----HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL--SISQSVHVAVKVPPLI-- 659
Query: 391 EPESRISAEVEETVDIGCQAMGVPLPT-LQWYKDA---ISISRLQNPRYKVLASGGLRIQ 446
+P A + + + I C +P + W KD IS S + + ++S L+I
Sbjct: 660 QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS--LQIS 717
Query: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506
+ + +G + C ASN + L + + P F +P + G +L C V G
Sbjct: 718 SVSLKHNGNYTCIASNAAATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGY 776
Query: 507 PKPAITWKRENHILASGSVR----IP---RFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
P P + WK H SG+ + +P R +L + L I V +D G Y C A+N
Sbjct: 777 PPPKVMWK---HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
Query: 560 GS-LNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP 618
G+ ++ S LTV I P + IKG L+C A + + +R W+K + + P
Sbjct: 834 GTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDP 891
Query: 619 SSTSRIVV-------EKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSP 671
R + E +L + GD +SC ++ G D + +L V E P P
Sbjct: 892 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 951
Query: 672 QNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPW--KVHLSNVGPEMTGVT 729
+ + + ++ L W + FDGNS I + +E + W K N+ P +
Sbjct: 952 E---LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQAN 1008
Query: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
+ L PA Y R+ + N++GR + S E + + E P PP ++ T+QSI V W
Sbjct: 1009 IVDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1067
Query: 790 QPPPETEHNGVLRGYILRYR--LAGLPGEYQ--QRNITSPEVNYCLVTDLIIWTQYEIQV 845
+ P + NGV+RGY + YR G G+Y + T Y L +L + QY + V
Sbjct: 1068 KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTL-DNLKKFAQYGVVV 1126
Query: 846 AAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGY 905
A+N AG G S + TL+ VP+ PP+NV+ ++ S W+ PP+ +NG+ +GY
Sbjct: 1127 QAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGY 1186
Query: 906 KLLAW----PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPST 961
+++ W + E + T + ++KFT Y VL +T GDG S+
Sbjct: 1187 RVIFWSLYVDGEWGEMQNITTTR------ERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1240
Query: 962 PQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTH 1021
+ T+ED PG + +S+ VSW P + NG+I Y I G +
Sbjct: 1241 VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSE 1300
Query: 1022 TLNSTTH-EYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN 1080
S Y+I L+ Y + VAAVT+ G G S V + G +IS
Sbjct: 1301 YETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG-----NSSEKVTIEPAGKAPAKIIS- 1354
Query: 1081 ISPRSATLQFRPGYDGKTSISRWIVEGQV--GAIGDEEEWVTLYEEENEPDAQMLEIPNL 1138
G T + W+ + ++ ++GD V ++ + + +
Sbjct: 1355 --------------FGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHR 1400
Query: 1139 TPYTHYRFRMKQVNIVGPSPYSPSSR---------VIQTLQAPPDVAPTSVTVRTASETS 1189
+T+ ++ V Y+ ++ V +Q PPD +TV S +S
Sbjct: 1401 LIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD--QPRLTVSKTSASS 1458
Query: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249
+ L W+P NG G+ ++Y S S V ER F ++ L+ Y+
Sbjct: 1459 ITLTWIP----GDNGGSSIRGFVLQY--SVDNSEEWKDVFISSSERSFKLDSLKCGTWYK 1512
Query: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
+++ A N+VG+G SE++ +T PS + + ++ST L ++ + G
Sbjct: 1513 VKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARL---NLQGWNNGGCP 1569
Query: 1310 LGYKILFRAKDLDPEPRS----HIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPS 1365
+ A L+ P+ +R N + L LR+ YEL++ A G G
Sbjct: 1570 I------TAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG-NE 1622
Query: 1366 TPLILERTKDDAPGPPVR 1383
T D + PP++
Sbjct: 1623 TAQFATLDYDGSTIPPIK 1640
Score = 239 bits (610), Expect = 2e-62
Identities = 365/1639 (22%), Positives = 625/1639 (38%), Gaps = 197/1639 (12%)
Query: 24 GPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRR-- 81
G G PR P +PS R SR AP G + A GR R A P RR
Sbjct: 3 GAGEPRREEPP-PQPSAGLR-----SRESGAPSAGGWERAERGRGAAARPATGPPPRRIG 56
Query: 82 ---GWWALLALQL--HLLRALAQDDVAPYFKTEPGLPQIHLEGN-RLVLTCLAEGSWPLE 135
G W + L L L +A +D + L Q+ + +V+ C A GS
Sbjct: 57 PLYGMWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAA 116
Query: 136 FKWMRDDSELTTYSSEYKYIIPSLQKLDAGF--------------------YRCVVRNRM 175
+W + + Y +P ++ + A Y C N
Sbjct: 117 LRWY-------LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAA 169
Query: 176 GALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR--PQVTWFREGHKII 233
G + V+ + + + + +G A+ L +S V+W ++ II
Sbjct: 170 GKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSII 229
Query: 234 PSNRIAITLENQLVILATTTSDAGAYYVQAVNEK-NGENKTSPFIHLSIARDVGTPETMA 292
P +R IT L I DA + Y K +GE + S LS+ P
Sbjct: 230 PEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT----DPAESI 285
Query: 293 PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGR--RLTIS 350
PTI+ ++ V AG + L C AS P+ ++ W ++G + + R LTIS
Sbjct: 286 PTILDGFHSQEVWAGHT-VELPCTASGYPIP--AIRWLKDGRPLPADSRWTKRITGLTIS 342
Query: 351 NPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQA 410
+ + D+G Y+CE + F A AT L +I+P + T P+ ++ + TV + C
Sbjct: 343 DLRTEDSGTYICEVT---NTFGSAEATGILMVIDPLHVTLTPK-KLKTGIGSTVILSCAL 398
Query: 411 MGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTH 470
G P T++WY++ + + + L++ L I + SG +QCFA+ + Q
Sbjct: 399 TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDF 458
Query: 471 TYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENH-ILASGSVRIPR 529
+ + + P + V G L C GAP P +TW ++ I+ GS R +
Sbjct: 459 AIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQ 518
Query: 530 FMLLES---GGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVI 586
+ + + + + I+D G Y C A N GS A + V SI + +
Sbjct: 519 YTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-RAMRNITAV 577
Query: 587 KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG-DIGDY 645
G ++C P S++ W KD AL R VV ++G+L ++ G D G+Y
Sbjct: 578 AGRDTLINCRVIGYPYYSIK--WYKD--ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 633
Query: 646 SCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFD----GNSPIL 701
C ++ + PQ L S H V ++PF+ +L
Sbjct: 634 LCSVLIQ------------------PQ--LSISQSVHVAVKVPPLIQPFEFPPASIGQLL 673
Query: 702 YYIVELSENNSPWKVHLSNVGPEM---TGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET 758
Y +S + P ++ G + +GVT+ + Q ++ G A
Sbjct: 674 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
Query: 759 SRLMLPEEPP---SAPPKNIVASGRTN--------QSIMVQWQPPPETE-HNGVLRGYIL 806
+ + E PP+ +V + + V PPP+ + G
Sbjct: 734 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
Query: 807 RYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQ 866
+Y L G Q +S + + L D+ + A NG G + +
Sbjct: 794 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYL-----CQASNGVGTDISKSMFLTVKIP 848
Query: 867 GVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYK--LLAWPAD----APEAVTV 920
+ T+ P +TTI + + +N +G + ++ W P+ V
Sbjct: 849 AMITSHP---------NTTIAIKGH---AKELNCTARGERPIIIRWEKGDTVIDPDRVMR 896
Query: 921 VTIAPDFHGVHHGHITNLK---KFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGH 977
IA +G LK + + F S + G+ V D P
Sbjct: 897 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP----E 952
Query: 978 LSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDS----RLTHTLNSTTHEYKIQ 1033
L E+ S+ + W + + N IITG+ I ++ ++DS + T ++ T ++ I
Sbjct: 953 LEIREVKARSMNLRWTQRFDGNSIITGFDIEYK--NKSDSWDFKQSTRNISPTINQANIV 1010
Query: 1034 GLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPG 1093
L + Y+I + + +G + S G P ++ + ++ +S + ++
Sbjct: 1011 DLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKA- 1069
Query: 1094 YDGKTSISRWIVEG-QVG----AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRM 1148
K + ++ G Q+G + G ++ ++ E + D+++ + NL + Y +
Sbjct: 1070 --PKKELQNGVIRGYQIGYRENSPGSNGQY-SIVEMKATGDSEVYTLDNLKKFAQYGVVV 1126
Query: 1149 KQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPES 1208
+ N G P S S TL+ P P +V + + + W P S NG +
Sbjct: 1127 QAFNRAGTGP-SSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK- 1184
Query: 1209 VGYRIKYWRSDLQSS-AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVV 1267
GYR+ +W + Q ++ ER + +E++ Y +Q+ A+ G G S V+
Sbjct: 1185 -GYRVIFWSLYVDGEWGEMQNITTTRER-VELRGMEKFTNYSVQVLAYTQAGDGVRSSVL 1242
Query: 1268 RGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRS 1327
+T+E VP P + A S++ ++++W +P NG+I Y I + S
Sbjct: 1243 YIQTKEDVP-GPPAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPS 1299
Query: 1328 HIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG-------- 1379
+A L + Y L V A T G G S + +E AP
Sbjct: 1300 EYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE-PAGKAPAKIISFGGT 1358
Query: 1380 ------PPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGAT 1433
VRL V + + W E + I + +RL HT T+ + A
Sbjct: 1359 VTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD-GHRLI----HTNGTLLLRAV 1413
Query: 1434 VRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR 1493
A +S Y + +A G+ + ++ PP + + ++ +A
Sbjct: 1414 --------KAEDSGY-YTCTATNTGGFDTIIVNLLV-------QVPPDQPRLTVSKTSAS 1457
Query: 1494 SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRL 1553
S+ L W+PG +G S IR F +Q EW+ IS + +D L+ T YK++L
Sbjct: 1458 SITLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFKLDSLKCGTWYKVKL 1515
Query: 1554 KATNDIGDSDFSSETEAVT 1572
A N +G S EA T
Sbjct: 1516 AAKNSVGSGRISEIIEAKT 1534
Score = 169 bits (428), Expect = 3e-41
Identities = 119/432 (27%), Positives = 201/432 (46%), Gaps = 30/432 (6%)
Query: 1475 ERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHE 1534
+ P P EL + EV ARS+ L+W DG S I F ++ + W S+ +
Sbjct: 945 QEPPDPPELEI--REVKARSMNLRWTQRFDGNSIITGFDIEYKN-KSDSWDFKQSTRNIS 1001
Query: 1535 AT---ACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHT 1591
T A +VD L P + Y +R+ + N IG S+ S E ++T + P PP V+ P T
Sbjct: 1002 PTINQANIVD-LHPASVYSIRMYSFNKIGRSEPSKEL-TISTEEAAPDGPPMDVTLQPVT 1059
Query: 1592 TSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFK 1651
+ S+ + W+ P+ E NG+++GY+I YRE GS Q S
Sbjct: 1060 SQSIQVTWKAPKKELQNGVIRGYQIGYRE--NSPGSN-----------------GQYSIV 1100
Query: 1652 TVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVT 1711
+ ++ S + L +LKK+ +Y V++ A+N G P+S+ + E P+ P+NV+
Sbjct: 1101 EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRAL 1160
Query: 1712 PLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSH 1771
+T+ ++W PP + NG ++GY++ +W E +M+ + V L+ +
Sbjct: 1161 SITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKF 1220
Query: 1772 TKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGI 1831
T Y V + A+ AGDG +S +T + PG P+ + +++++ VSW P NG+
Sbjct: 1221 TNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV 1280
Query: 1832 LQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQ 1891
++ Y + +P G E Q + ++ L +G Y V A T
Sbjct: 1281 IRKYTIFCS--SPGSGQPAPSEYETSPE-QLFYRIAHLNRGQQYLLWVAAVTSAGRGNSS 1337
Query: 1892 ANITAGPAEGSP 1903
+T PA +P
Sbjct: 1338 EKVTIEPAGKAP 1349
Score = 168 bits (426), Expect = 5e-41
Identities = 167/644 (25%), Positives = 275/644 (42%), Gaps = 77/644 (11%)
Query: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSS-PHTFTT 1427
+++ T + P PP L EV+ S+ + W + N II G+ I Y+ S S +T
Sbjct: 939 LIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQST 997
Query: 1428 VEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ 1487
+ T+ Q DL P S Y R+ + + G EP + I+TE+ PP + V
Sbjct: 998 RNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD--VTL 1055
Query: 1488 AEVTARSLRLQW-VPGSD-GASPIRYFTMQVREL---PRGEWQTYSSSISHEATACVVDR 1542
VT++S+++ W P + IR + + RE G++ + ++ +D
Sbjct: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
Query: 1543 LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPP 1602
L+ F Y + ++A N G SSE A TTL+DVP +PP +V A T+ +I W P
Sbjct: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINA-TTLEDVPSQPPENVRALSITSDVAVISWSEP 1174
Query: 1603 RDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMC 1662
+LNG+L+GYR+ + L Y G E + N ++T
Sbjct: 1175 PRSTLNGVLKGYRVIFWSL-YVDGEWGEMQ---------------------NITTTRERV 1212
Query: 1663 ELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW 1722
EL ++K+ Y V + AY G+ S+ + + E P P ++ P +AS + V+W
Sbjct: 1213 ELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPSSASSVVVSW 1271
Query: 1723 DPPPPESQNGNIQGYKIYY------WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLV 1776
PP NG I+ Y I+ A S+ ET ++ + R+ +L +YL+
Sbjct: 1272 --LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY------RIAHLNRGQQYLL 1323
Query: 1777 SISAFNAAGDGPKSDPQQGRTHQAAPGAPS-FLAFSEITSTTLNVSWGEPAAANGILQGY 1835
++A +AG G S+ T + A AP+ ++F +T P + G
Sbjct: 1324 WVAAVTSAGRGNSSEKV---TIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVG----- 1375
Query: 1836 RVVYEPLAPVQGV--SKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQAR-------TITY 1886
+P V+ S+ + V + R + T G V+A T T
Sbjct: 1376 ----DPAPAVKWTKDSEDSAIPVSMDGHRLIH----TNGTLLLRAVKAEDSGYYTCTATN 1427
Query: 1887 GPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGL 1946
I + P PR + SAS +TL W G +G + G+V++ +
Sbjct: 1428 TGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEE 1487
Query: 1947 WDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1990
W KD+ S++ + LD L+ G Y+ ++ A N G G S
Sbjct: 1488 W----KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
Score = 115 bits (289), Expect = 4e-25
Identities = 167/731 (22%), Positives = 287/731 (39%), Gaps = 83/731 (11%)
Query: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHT-QSA 1338
P + V + + L WT D N +I G+ I ++ K + + + T A
Sbjct: 950 PPELEIREVKARSMNLRWTQ--RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA 1007
Query: 1339 LLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVW 1398
+ L +Y +++ +F +IG PS L + + GPP+ + V S+++ W
Sbjct: 1008 NIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1067
Query: 1399 QPPEEP--NGIILGYQIAYRLAS-SSPHTFTTVEVGAT--VRQFTATDLAPESAYIFRLS 1453
+ P++ NG+I GYQI YR S S ++ VE+ AT +T +L + Y +
Sbjct: 1068 KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1127
Query: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV--PGSDGASPIRY 1511
A R G G P + + T + P+ P E V +T+ + W P S ++
Sbjct: 1128 AFNRAGTG-PSSSEINATTLEDVPSQPPEN-VRALSITSDVAVISWSEPPRSTLNGVLKG 1185
Query: 1512 FTMQVREL-PRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEA 1570
+ + L GEW + I+ + + FT+Y +++ A GD SS
Sbjct: 1186 YRVIFWSLYVDGEWGEMQN-ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLY- 1243
Query: 1571 VTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTE 1630
+ T +DVPG PP + A P + SSV++ W PP NG+++ Y I+ GSG
Sbjct: 1244 IQTKEDVPG-PPAGIKAVPSSASSVVVSWLPPTKP--NGVIRKYTIFCSS----PGSGQP 1296
Query: 1631 AKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASA 1690
A S ++T S + HL + ++Y + + A G +S
Sbjct: 1297 AP---------------SEYET---SPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
Query: 1691 PVEVFVGEAAPA--MAPQNVQVTPLTAS---QLEVTWDPPPPESQNGNIQGYKIYYWEAD 1745
V + APA ++ TP DP P W D
Sbjct: 1339 KVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVK------------WTKD 1386
Query: 1746 SQNETEKMKV----LFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAA 1801
S++ + + L + L+ + + + +A N G Q
Sbjct: 1387 SEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII---VNLLVQVP 1443
Query: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQ 1861
P P L S+ +++++ ++W ++G+ + Y V + V + + +
Sbjct: 1444 PDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYS----VDNSEEWKDVFISSS-E 1497
Query: 1862 RWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRD----VLVTKSASE 1917
R K+ L G Y ++ A+ + I A P +D + + +
Sbjct: 1498 RSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHAR 1557
Query: 1918 LTLQ-WTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976
L LQ W ++G P T V+E RP W R+ +S + L +LR+ YE
Sbjct: 1558 LNLQGW---NNGGCPITAIVLEYRPKGTWAWQGL-----RANSSGEVFLTELREATWYEL 1609
Query: 1977 RVVAVNEAGYG 1987
R+ A N AG G
Sbjct: 1610 RMRACNSAGCG 1620
Score = 70.1 bits (170), Expect = 2e-11
Identities = 71/293 (24%), Positives = 130/293 (44%), Gaps = 22/293 (7%)
Query: 593 LHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSE 652
L C + DP ++++ ++ A+ S ++ +G+LL+ + D G Y+C +
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 653 GGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS-ENN 711
GG D+ + L ++++P L VS S+ S + L+W+ +G S I ++++ S +N+
Sbjct: 1429 GGFDTIIVNL-LVQVPPDQPRLTVSKTSASS--ITLTWIPGDNGGSSIRGFVLQYSVDNS 1485
Query: 712 SPWK-VHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSA 770
WK V +S+ + L Y+ ++ A N VG G+ S EP +
Sbjct: 1486 EEWKDVFISS---SERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFS 1542
Query: 771 PPKNIVAS-GRTNQSIMVQ-WQPPPETEHNG--VLRGYILRYRLAGLPGEYQQRNITSPE 826
+++ T+ + +Q W +NG + +L YR G R +S E
Sbjct: 1543 KDQHLFTHINSTHARLNLQGW-------NNGGCPITAIVLEYRPKGTWAWQGLRANSSGE 1595
Query: 827 VNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTE 879
V +T+L T YE+++ A N AG G + G P ++ Q E
Sbjct: 1596 V---FLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGE 1645
Score = 42.0 bits (97), Expect = 0.007
Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 5/140 (3%)
Query: 1864 LKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWT 1923
LK++ +G + FF A +YG + + + P P + A + L+WT
Sbjct: 912 LKLKPADRGDSVFFSCHAIN-SYGED--RGLIQLTVQEPPDPPELEIREVKARSMNLRWT 968
Query: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNE 1983
+ G++ TG+ IE + + WD S T ++ L Y R+ + N+
Sbjct: 969 QRFDGNSIITGFDIEYKNKSDS-WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
Query: 1984 AGYGEPSNPSTAVSAQVEAP 2003
G EPS T +S + AP
Sbjct: 1028 IGRSEPSKELT-ISTEEAAP 1046
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 284 bits (726), Expect = 8e-76
Identities = 251/1003 (25%), Positives = 439/1003 (43%), Gaps = 88/1003 (8%)
Query: 124 LTCLAEGSWPLEFKWMRD-------DSELTTYSSEYKYIIPSLQKLD--AGFYRCVVRNR 174
+ C A+G+ F W +D D + ++ + IP+ + G YRC N+
Sbjct: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
Query: 175 MGALLQRKSEVQVAYMGSF-MDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFR-EGHKI 232
+G + + E V + F + V +G +L P P + W E I
Sbjct: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHI 174
Query: 233 IPSNRIAITLENQLVILATTTSDAGAYY------------VQAVNEKNGENKTSPFIHLS 280
R+ ++ + L D+ Y VQ + K N S
Sbjct: 175 EQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSS 234
Query: 281 IARDVGTP----ETMAPTIVVPP---GNRS--VVAGSSETTLECIASARPVEDLSVTWKR 331
+ ++G+ + P +++PP G+ S + LEC A P V W +
Sbjct: 235 SSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQ--VDWNK 292
Query: 332 NGVRITSGLHS---FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYF 388
G + G + +G+ L I N + D G Y C A+ + A + + EPP +
Sbjct: 293 IGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTAS---NFLGTATHDFHVIVEEPPRW 349
Query: 389 TAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYK--VLASGGLRIQ 446
T +P+S + + + + C+A G P PT++W ++ S + N + V+ +
Sbjct: 350 TKKPQSAVYSTGSNGILL-CEAEGEPQPTIKW---RVNGSPVDNHPFAGDVVFPREISFT 405
Query: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD-GMTAILRCEVSG 505
L+P + ++QC ASN G I + +DV ++ P+ + + T G +A L CE
Sbjct: 406 NLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFA 465
Query: 506 APKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNAS 565
+P+ ++W++ + + R+ + E+G LQI +DAG+Y+C+ N G +
Sbjct: 466 SPEAVVSWQKVEEVKP---LEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVT 522
Query: 566 ATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRV--SLRYVWKKDNVALTPSSTS- 622
A L + N T + P++ + K LHC + D + SL+ W KD A + T
Sbjct: 523 ANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTED 582
Query: 623 -RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSS 681
RI+++ +L IS D G Y C + + + + ++ V+++P P+NL +S +
Sbjct: 583 GRIIID-GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQN 641
Query: 682 HSHAVVLSWVRPFDGNSPILYYIVELSENNSP---WKVHLSNVGPEMTGVTVSGLTPART 738
S V L+W D NS I YIVE N W+ L+ V + T V + L P
Sbjct: 642 RS--VRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE-ELTRVQGKKTTVILP-LAPFVR 697
Query: 739 YQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHN 798
YQFRV AVNEVGR Q S + P P P+NI + ++++W+P E N
Sbjct: 698 YQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQN 757
Query: 799 GVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSR 858
G Y + ++ G P E+++ +T+ + V ++ Y+++V A N G G +
Sbjct: 758 GPGLEYRVTWKPQGAPVEWEEETVTNHTLR---VMTPAVYAPYDVKVQAINQLGSGPDPQ 814
Query: 859 AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADA---- 914
+VT Y+ + P P + +NST ++ W+ P+ ++G +GY++ W +
Sbjct: 815 SVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDG 874
Query: 915 ---PEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDK 971
P+ V ++ + + G + +L F+ + +VL + + G GP S P + T E
Sbjct: 875 RTHPKEVNILRFSGQRNS---GMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGV 931
Query: 972 PGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQI-------SWEVYGRNDSRLTHTLN 1024
P L ++ + +SW P + NG +TGY + ++E+ ND +T
Sbjct: 932 PEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSK 991
Query: 1025 STTHEYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSG 1064
+ H + L++ T Y + A T+ G G SST+ G
Sbjct: 992 PSWH---LSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEG 1031
Score = 142 bits (358), Expect = 4e-33
Identities = 136/540 (25%), Positives = 236/540 (43%), Gaps = 55/540 (10%)
Query: 984 LDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTI 1043
L SLK+SW + E ++E+ G D R+ + T +S++T
Sbjct: 560 LKHSLKLSWSKDGE----------AFEINGTEDGRIIIDGANLT-------ISNVTLEDQ 602
Query: 1044 DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRW 1103
+ +A T L +++ I+ D+P P NL +S RS L + G D ++IS +
Sbjct: 603 GIYCCSA-HTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEY 661
Query: 1104 IVEGQVGAIGDEEE---WVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS 1160
IVE + G++EE W L + + +L L P+ Y+FR+ VN VG S S
Sbjct: 662 IVEFE----GNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNEVGRSQPS 714
Query: 1161 PSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL 1220
S +T A PD P ++ V+ + + ++W PL + NG + YR+ +
Sbjct: 715 QPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--PGLEYRVTWKPQGA 772
Query: 1221 QSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAP 1280
+ V++ R T + Y++++QA N +G+GP + V + E P AP
Sbjct: 773 PVEWEEETVTNHTLRVMTPAV---YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829
Query: 1281 ENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKI-LFRAKDL-----DPEPRSHIVRGNH 1334
+ ++ST + +TW++VP+ +G + GY+I ++ K L P+ + +
Sbjct: 830 VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889
Query: 1335 TQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSV 1394
S ++ L F + L VLA+ G G S P I + T + P P L +V +
Sbjct: 890 RNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQ-TPEGVPEQPTFLKVIKVDKDTA 948
Query: 1395 RIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATV---RQFTATDLAPESAYIFR 1451
+ W P++ NG + GY + Y++ + + ++ T + ++L + Y F
Sbjct: 949 TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY 1008
Query: 1452 LSAKTRQGWGEPLEATVITTEKRER------------PAPPRELLVPQAEVTARSLRLQW 1499
L A T QG G+P+ T + + P E+ P AE R + W
Sbjct: 1009 LRACTSQGCGKPITEESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNW 1068
Score = 126 bits (316), Expect = 3e-28
Identities = 99/416 (23%), Positives = 182/416 (43%), Gaps = 39/416 (9%)
Query: 1477 PAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV---RELPRGEWQTYSSSISH 1533
P PP L + + + RS+RL W G+D S I + ++ +E P G W+ +
Sbjct: 628 PDPPENLHLSERQ--NRSVRLTWEAGADHNSNISEYIVEFEGNKEEP-GRWEELTRVQGK 684
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ T V+ L PF Y+ R+ A N++G S S ++ T P P ++
Sbjct: 685 KTT--VILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPK 742
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
++I+W+P + NG YR+ + K P+ E + + +
Sbjct: 743 EMIIKWEPLKSMEQNGPGLEYRVTW-------------KPQGAPVEWEEETVTNHTLRVM 789
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ Y Y+V + A N +G P V ++ GE P AP V +
Sbjct: 790 TPAV------------YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVI 837
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVR----LKN 1767
++ ++VTW P + +G ++GY+I +W+ S T +V L R + +
Sbjct: 838 NSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPS 897
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L + +++ +++ A+N+ G GP+S+P +T + P P+FL ++ T +SWG P
Sbjct: 898 LDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKK 957
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART 1883
NG L GY + Y+ + + ++ + + + + +L Y F ++A T
Sbjct: 958 LNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACT 1013
Score = 47.0 bits (110), Expect = 2e-04
Identities = 47/183 (25%), Positives = 75/183 (40%), Gaps = 22/183 (12%)
Query: 386 PYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY----KVLASG 441
P + + +++ +E I C+A G P PT W KD NP Y +++ S
Sbjct: 35 PTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG-------NPFYFTDHRIIPSN 87
Query: 442 GLRIQKLRPED-----SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
++ E G ++CFASN+ G + + P F + +D V +G
Sbjct: 88 NSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGD 147
Query: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGN-YTC 553
+L C G P I W +I + R + + G L A V +D+ N Y C
Sbjct: 148 PIVLPCNPPKGLPPLHIYWM---NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCC 204
Query: 554 YAA 556
+AA
Sbjct: 205 FAA 207
Score = 43.9 bits (102), Expect = 0.002
Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 7/115 (6%)
Query: 1892 ANITAGPAEGSPGSPRDV-LVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDE--GLWD 1948
A+IT P P ++ L + + L W G ++ + Y++E + E G W+
Sbjct: 617 ADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE 676
Query: 1949 MFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
++ R T + L V Y+FRV+AVNE G +PS PS AP
Sbjct: 677 ----ELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727
Score = 38.1 bits (87), Expect = 0.097
Identities = 87/381 (22%), Positives = 132/381 (34%), Gaps = 44/381 (11%)
Query: 117 LEGNRLVLTCLAEGSWPLEFKWMRDDSEL-------TTYSSEYKYIIPSLQKLDAGFYRC 169
L+G L+L C AEG + W + +L Y K I ++ D G YRC
Sbjct: 269 LKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLK--IENVSYQDKGNYRC 326
Query: 170 VVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREG 229
N +G V V + Q S G IL L P+P + W R
Sbjct: 327 TASNFLGT-ATHDFHVIVEEPPRWTKKPQSAVYSTGSNGIL-LCEAEGEPQPTIKW-RVN 383
Query: 230 HKIIPSNRIA--ITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGT 287
+ ++ A + ++ + Y +A N +H +I +
Sbjct: 384 GSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASN-----------VHGTILANANI 432
Query: 288 PET-MAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR-NGVRITSG--LHSF 343
+ P I G L C A P + V+W++ V+ G H +
Sbjct: 433 DVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASP--EAVVSWQKVEEVKPLEGRRYHIY 490
Query: 344 -GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPES-RISA--E 399
L I+ T D G Y C +A TA L I P++ RI
Sbjct: 491 ENGTLQINRTTEEDAGSYSCWVE---NAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHM 547
Query: 400 VEETVDIGCQAMGVPLPTLQWYKD--AISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQ 457
+E + C + L W KD A I+ ++ R ++ L I + ED GI+
Sbjct: 548 LELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLEDQGIYC 606
Query: 458 CFAS---NEGGEIQTHTYLDV 475
C A + +I T LDV
Sbjct: 607 CSAHTALDSAADITQVTVLDV 627
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 283 bits (724), Expect = 1e-75
Identities = 322/1164 (27%), Positives = 495/1164 (42%), Gaps = 143/1164 (12%)
Query: 385 PPYFTAEP--ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVL---- 438
PP FT P ++ +S V + CQA G P P + W K +S N R++V+
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFI---CQATGDPRPKIVWNKKGKKVS---NQRFEVIEFDD 76
Query: 439 ASGG-LRIQKLR-PEDSGIFQCFASNEGGEIQTHTYLDVTNIA------PVFTQRPVDTT 490
SG LRIQ LR P D I++C ASN GEI T L V P P
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 491 VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLES---------GGLQIA 541
V TA + C SG P P ITW ++ + S R L S G LQI
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKD-FLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
Query: 542 PVFIQDAGNYTCYAANTEGS-LNASATLTVWNRTSIVH-------PPEDHVVIKGTTATL 593
D G Y C A N+ G+ +A A L V + PP +H ++ G + +
Sbjct: 196 QSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNI 255
Query: 594 HCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
C A P ++++ ++ LTP I G ++ +Y+C +S
Sbjct: 256 TCVAVGSPMPYVKWMLGAED--LTPEDDMPI-----GRNVLELNDVRQSANYTCVAMSTL 308
Query: 654 GNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGN-SPILYYIVELSENNS 712
G +A++ V LP P +V+ +++ S + L+W GN P+ YYI++ NS
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATS--ITLTWD---SGNPEPVSYYIIQHKPKNS 363
Query: 713 PWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPP 772
+++ G T +V+GL+P Y+FRV AVN +GRG S E E+ PS+ P
Sbjct: 364 E-ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQTSEQAPSSAP 421
Query: 773 KNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLP--GEYQQRNITSPEVNYC 830
+++ A ++ +I+VQW+ P E NG ++GY + Y + + + N+ ++
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEP--NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT-- 477
Query: 831 LVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW 890
+ +L+ Y ++V A+ G G S + T GVP P N + E + T+I W
Sbjct: 478 TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSW 536
Query: 891 NPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLC 950
PP I Y+L+ + E +TI P G + + LK + Y+ +
Sbjct: 537 TPPRSDTI----ANYELVYKDGEHGEEQR-ITIEP---GTSY-RLQGLKPNSLYYFRLAA 587
Query: 951 FTTPGDGPPSTPQLVWTQEDKPGAVGH-LSFTEILDTSLKVSWQ-EPLEK-NGIITGYQI 1007
+ G G + T + KP A +S T TS+ VSWQ P+EK NGIIT Y I
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 1008 SWEVYGRNDSRLTHTLN--STTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGV 1065
+ D + L S T +Y ++ L T Y I V A T VG G S ++
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRT 706
Query: 1066 PPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEE 1124
D+P G P + + ++ S + +R K GQ+ G + +V + E
Sbjct: 707 NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ-------HGQIR--GYQVHYVRM--E 755
Query: 1125 ENEPDAQ-MLE--------------------IPNLTPYTHYRFRMKQVNIVGPSPYSPSS 1163
EP Q ML+ I L P T Y + G S
Sbjct: 756 NGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS-KP 814
Query: 1164 RVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSS 1223
+++ T A P P V T T+L ++W P D+ GYR+K+ R D++
Sbjct: 815 KLVSTTGAVPG-KPRLVINHTQMNTAL-IQWHPPVDT----FGPLQGYRLKFGRKDMEPL 868
Query: 1224 AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPEN 1282
+ E FT ++ + Y ++ A N VG G E+V+ E VP+ P+N
Sbjct: 869 TTLEF--SEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQN 924
Query: 1283 VSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAG 1342
+ +E +ST + L+W ++NG+I Y +L+R ++ P ++ T + L G
Sbjct: 925 LHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTG 983
Query: 1343 LRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE------VRLTSVRI 1396
L+ Y+++V A T G G P +P + RT PV VF + V TSV +
Sbjct: 984 LKPDTTYDVKVRAHTSKGPG-PYSPSVQFRTL------PVDQVFAKNFHVKAVMKTSVLL 1036
Query: 1397 VWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKT 1456
W+ PE N + ++I Y EV Q +L PE +Y F L+ +
Sbjct: 1037 SWEIPENYNS-AMPFKILYDDGK------MVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1089
Query: 1457 RQGWGEPLEATVITTEK--RERPA 1478
G T T R +PA
Sbjct: 1090 NSAGGLQHRVTAKTAPDVLRTKPA 1113
Score = 221 bits (564), Expect = 5e-57
Identities = 275/1105 (24%), Positives = 453/1105 (40%), Gaps = 141/1105 (12%)
Query: 568 LTVWNRTSIVHPPE------DHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSST 621
LT + RT PP D + G A+ C AT DPR + VW K + S+
Sbjct: 12 LTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKI--VWNKKGKKV--SNQ 67
Query: 622 SRIVVEKD---GSLLISQTWSG--DIGDYSCEIVSEGGNDSRMARLEVI---ELPHSPQN 673
V+E D GS+L Q D Y C + G S RL V+ ++P
Sbjct: 68 RFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPT 127
Query: 674 LLVSPN---------------SSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHL 718
+ + P +S + ++W + F V+ S NN K
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDF--------LPVDTSNNNGRIK--- 176
Query: 719 SNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVAS 778
++ ++ G TP R ++ E +G+Y + SAP V
Sbjct: 177 -----QLRSESIGG-TPIRG-ALQIEQSEESDQGKYECVATNSAGTRY--SAPANLYVRE 227
Query: 779 GRTNQSIMVQWQPPPETEHNGVLRGYI-LRYRLAGLPGEYQQRNI----TSPEVNYCLVT 833
R + + ++ PP T H + G + + G P Y + + +PE + +
Sbjct: 228 LREVRRVPPRFSIPP-TNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGR 286
Query: 834 DLIIWTQYEIQVAAYNGAGLGVFS--RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW- 890
+++ Q A Y + A+ + T++ +P P V TE+ +T+I W
Sbjct: 287 NVLELNDVR-QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST-ATSITLTWD 344
Query: 891 --NPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSV 948
NP P + Y + P ++ E + D + L ++ Y V
Sbjct: 345 SGNPEPVSY-------YIIQHKPKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRV 393
Query: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKNGIITGYQI 1007
+ G GPPS P L T E P + +L T++ V W+EP E NG I GY++
Sbjct: 394 VAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV 453
Query: 1008 -----------SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLV 1056
+W + DS++T I L TY++ V A T++G G +
Sbjct: 454 YYTMDPTQHVNNWMKHNVADSQIT----------TIGNLVPQKTYSVKVLAFTSIGDGPL 503
Query: 1057 TSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEE 1116
SS I +PG P N S S L + P +I+ + + + G G+E+
Sbjct: 504 -SSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--PRSDTIANYELVYKDGEHGEEQ 560
Query: 1117 EWVTLYEEENEPDAQMLEIPNLTPYTHYRFRM--KQVNIVGPSPYSPSSRVIQTLQAPPD 1174
+T+ EP + L P + Y FR+ + +G S S+R T+Q+ P
Sbjct: 561 R-ITI-----EPGTSY-RLQGLKPNSLYYFRLAARSPQGLGASTAEISAR---TMQSKPS 610
Query: 1175 VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLE 1234
P ++ + S TS+ + W P P + NG Y IKY D + +++ +
Sbjct: 611 APPQDISCTSPSSTSILVSWQPPPVEKQNGIITE--YSIKYTAVDGEDDKPHEILGIPSD 668
Query: 1235 R-EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQI 1293
++ +E+LE+W EY + + A VG GP S V RT E VPS P V EAV+ST +
Sbjct: 669 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 728
Query: 1294 LLTWTSVPEQDQNGLILGYKILF-RAKDLDPEPRSHI-----------VRGNHTQSALLA 1341
++W S Q+G I GY++ + R ++ +P+ + + +++
Sbjct: 729 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIIS 788
Query: 1342 GLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP 1401
GL+ Y L V A+T G+G S P ++ T PG P RLV ++ + I W PP
Sbjct: 789 GLQPETSYSLTVTAYTTKGDGARSKPKLVS-TTGAVPGKP-RLVINHTQMNTALIQWHPP 846
Query: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
+ G + GY++ + P TT+E FTATD+ ++Y+FRLSA+ + G+G
Sbjct: 847 VDTFGPLQGYRLKFGRKDMEP--LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1462 EPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPG--SDGASPIRYFTMQVREL 1519
E + + E+ P + T+ S++L W P ++ I +T+ R++
Sbjct: 905 EEMVKEISIPEEVPTGFPQN---LHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI 961
Query: 1520 PRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG 1579
I T + L+P T+Y ++++A G +S + T D
Sbjct: 962 -NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020
Query: 1580 EPPGSVSATPHTTSSVLIQWQPPRD 1604
V A T SVL+ W+ P +
Sbjct: 1021 AKNFHVKAVMKT--SVLLSWEIPEN 1043
Score = 210 bits (534), Expect = 1e-53
Identities = 204/781 (26%), Positives = 341/781 (43%), Gaps = 81/781 (10%)
Query: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
E + T +++P V E+ ++T I LTW S + + I+ +K +++L E
Sbjct: 312 EAIAQITVKALPKPPGTPVVTES-TATSITLTWDSGNPEPVSYYIIQHKPK-NSEELYKE 369
Query: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
+ G T +AGL + YE +V+A IG G PS P +L +T + AP R
Sbjct: 370 -----IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP-VLTQTSEQAPSSAPRD 423
Query: 1385 VFPEV-RLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT-DL 1442
V + T++ + W+ PEEPNG I GY++ Y + + H ++ Q T +L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM-DPTQHVNNWMKHNVADSQITTIGNL 482
Query: 1443 APESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLV-PQAEVTARSLRLQWVP 1501
P+ Y ++ A T G G PL + + + P P P++E S+ L W P
Sbjct: 483 VPQKTYSVKVLAFTSIGDG-PLSSDIQVITQTGVPGQPLNFKAEPESET---SILLSWTP 538
Query: 1502 GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGD 1561
+ I + + ++ GE Q + T+ + L+P + Y RL A + G
Sbjct: 539 PR--SDTIANYELVYKDGEHGEEQRITIE---PGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 1562 SDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYREL 1621
++E A T+Q P PP +S T +++S+L+ WQPP E NG++ Y I Y +
Sbjct: 594 GASTAEISA-RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAV 652
Query: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
+ E E + S +T L L+K+ Y + +TA+
Sbjct: 653 DGEDDKPHEI---------------------LGIPSDTTKYLLEQLEKWTEYRITVTAHT 691
Query: 1682 IIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY 1741
+G P S V + E P+ P+ V+V + ++ ++V+W P P Q+G I+GY+++Y
Sbjct: 692 DVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 751
Query: 1742 --WEADSQNETEKMKVLFLPEPVVRLKNLTSH----------TKYLVSISAFNAAGDGPK 1789
E +K + L + + T H T Y ++++A+ GDG +
Sbjct: 752 VRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 811
Query: 1790 SDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVY-----EPLAP 1844
S P+ T A PG P L + T + W P G LQGYR+ + EPL
Sbjct: 812 SKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT 870
Query: 1845 VQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITYGPELQANITAGPAEGSP 1903
++ K + D+ KG +Y FR+ AR + +G E+ I+ P E
Sbjct: 871 LEFSEK----------EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI-PEEVPT 919
Query: 1904 GSPRDVL---VTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960
G P+++ T ++ +L+ Q + T Y + R + L M +P
Sbjct: 920 GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-- 977
Query: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAV-SAQVEAPFYEEWWFLLVMALSSL 2019
T++L L+ TY+ +V A G G P +PS + V+ F + + VM S L
Sbjct: 978 -TMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVL 1035
Query: 2020 I 2020
+
Sbjct: 1036 L 1036
Score = 199 bits (505), Expect = 3e-50
Identities = 265/1075 (24%), Positives = 437/1075 (40%), Gaps = 147/1075 (13%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLE------NQLVILATTTSDAGAYYVQAVNEKNG 269
T PRP++ W ++G K+ SN+ +E + L I T A Y + G
Sbjct: 48 TGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVG 105
Query: 270 ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW 329
E S L++ R+ P PTI + P VV + T+ C AS P D +TW
Sbjct: 106 EISVS--TRLTVLREDQIPRGF-PTIDMGP-QLKVVERTRTATMLCAASGNP--DPEITW 159
Query: 330 KRNGVRITSGLHSFGR----------------RLTISNPTSADTGPYVCEAALPGSAFEP 373
++ + + + ++ GR L I +D G Y C A SA
Sbjct: 160 FKDFLPVDTS-NNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVAT--NSAGTR 216
Query: 374 ARATAFLFIIE-------PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS 426
A A L++ E PP F+ P + +V+I C A+G P+P ++W A
Sbjct: 217 YSAPANLYVRELREVRRVPPRFSIPPTNH-EIMPGGSVNITCVAVGSPMPYVKWMLGAED 275
Query: 427 ISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRP 486
++ + + L + +R S + C A + G I+ + V + P P
Sbjct: 276 LTPEDD---MPIGRNVLELNDVR--QSANYTCVAMSTLGVIEAIAQITVKAL-PKPPGTP 329
Query: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ 546
V T T T+I SG P+P ++ + + + E G+ +
Sbjct: 330 VVTEST--ATSITLTWDSGNPEPV------SYYIIQHKPKNSEELYKEIDGVATTRYSVA 381
Query: 547 DAGNYTCY-----AANTEG-SLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGAT 598
Y+ Y A N G + LT + + P D ++ TT +
Sbjct: 382 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 441
Query: 599 HDPRVSLRYV--------------WKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGD 644
+P ++ W K NVA + +T G+L+ +T+S +
Sbjct: 442 EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI-------GNLVPQKTYSVKVLA 494
Query: 645 YSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYI 704
++ + +G S + + +P P N P S S ++LSW P +
Sbjct: 495 FTS--IGDGPLSSDIQVITQTGVPGQPLNFKAEPESETS--ILLSWTPPRSDTIANYELV 550
Query: 705 VELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLP 764
+ E+ ++ + T + GL P Y FR+ A + G G +AE S +
Sbjct: 551 YKDGEHGEEQRITIE----PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM- 605
Query: 765 EEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE----YQQR 820
+ PSAPP++I + ++ SI+V WQPPP + NG++ Y ++Y + GE ++
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY--TAVDGEDDKPHEIL 663
Query: 821 NITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEA 880
I S Y L+ L WT+Y I V A+ G G S +V T + VP+ PP+ V+ EA
Sbjct: 664 GIPSDTTKY-LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA 722
Query: 881 VNSTTIQFLWNPPPQQFINGINQGYKL------LAWPADAPEAVTVVTIAP----DFHGV 930
VNST+++ W P +G +GY++ P P V+ D
Sbjct: 723 VNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTE 782
Query: 931 HHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKV 990
H I+ L+ T+Y +V +TT GDG S P+LV T PG + ++T+L +
Sbjct: 783 HDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-I 841
Query: 991 SWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHE--YKIQGLSSLTTYTIDVAAV 1048
W P++ G + GY++ +GR D TL + E + + +Y ++A
Sbjct: 842 QWHPPVDTFGPLQGYRLK---FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSAR 898
Query: 1049 TAVGTGLVTSSTISSGVPPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEG 1107
VG G IS +P ++P G P NL + S L ++P ++
Sbjct: 899 NKVGFGEEMVKEIS--IPEEVPTGFPQNLHSEGTTSTSVQLSWQPP----------VLAE 946
Query: 1108 QVGAIGDEEEWVTLYEEENEPDAQM----------LEIPNLTPYTHYRFRMKQVNIVGPS 1157
+ G I ++ LY + N P M + + L P T Y +++ GP
Sbjct: 947 RNGII---TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003
Query: 1158 PYSPSSRVIQTLQAPPD-VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGY 1211
PYSPS +Q P D V + V+ +TS+ L W +P++ + P + Y
Sbjct: 1004 PYSPS---VQFRTLPVDQVFAKNFHVKAVMKTSVLLSW-EIPENYNSAMPFKILY 1054
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 282 bits (722), Expect = 2e-75
Identities = 257/1023 (25%), Positives = 437/1023 (42%), Gaps = 89/1023 (8%)
Query: 86 LLALQLHLLRALAQDD--VAPYFKTEPG---LPQIHLEGNRLVLTCLAEGSWPLEFKWMR 140
L+ + + A++++D P F+ +P P+ LEG ++ L C A S +KW
Sbjct: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEG-KVSLNCRARASPFPVYKWRM 68
Query: 141 DDSELTTYSSEYKYIIPSL------QKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFM 194
++ ++ S Y + +L ++ DAG Y C+ N G + ++ + Y+ F
Sbjct: 69 NNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
Query: 195 DTDQRKT-VSQGRAAILNLLPITSYPRP-QVTWFREGHKI---IPSNRIAITLENQLVIL 249
++ + V +G+ +L P +P W + + R L I
Sbjct: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
Query: 250 ATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSS 309
SD G Y + ++ S FI L I T + IVV + + G +
Sbjct: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPL-IPIPERTTKPYPADIVVQFKDVYALMGQN 247
Query: 310 ETTLECIASARPVEDLSVTWKR--NGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA-L 366
TLEC A PV D + W++ + T+ + + G L I N D G Y CEA +
Sbjct: 248 -VTLECFALGNPVPD--IRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENI 304
Query: 367 PGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIG------CQAMGVPLPTLQW 420
G AR Y A PE + + VDIG C A G P+PT++W
Sbjct: 305 RGKDKHQARI----------YVQAFPEW-VEHINDTEVDIGSDLYWPCVATGKPIPTIRW 353
Query: 421 YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP 480
K+ + + G LR+ + E++G++QC A N G I + L + +AP
Sbjct: 354 LKNGYAYHK-----------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAP 402
Query: 481 VFTQRPVDTTV--TDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGL 538
F P+ + G I+ C+ APKP +W + L + S R ++ E G L
Sbjct: 403 TFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSS----RILIWEDGSL 458
Query: 539 QIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGAT 598
+I + D G YTC+A N G N++ TL + + T I+ P + + G AT+ C A+
Sbjct: 459 EINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAAS 518
Query: 599 HDPRVSLRYVWKKDNVALTPSSTS-----RIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
DP + L +VW + + + + +++ +G LLI G Y+C +
Sbjct: 519 FDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIV 578
Query: 654 GNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVE----LSE 709
N S A L V P P L + + +V L+W R D +SPI Y ++ LS+
Sbjct: 579 DNSSASADLVVRGPPGPPGGLRI--EDIRATSVALTWSRGSDNHSPISKYTIQTKTILSD 636
Query: 710 NNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPS 769
+ K + M L P Y+FRV A N +GRG+ S ++R+ P+
Sbjct: 637 DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
Query: 770 APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNY 829
P ++ G N+ + + W P H G GYI+ ++ E+++ +T+P+
Sbjct: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFD-GEEWKKVTVTNPDTGR 755
Query: 830 CLVTD--LIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQ 887
+ D + T ++++V A+N G G +S + Q P+ P V + ++S+ I
Sbjct: 756 YVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEIS 815
Query: 888 FLWNPPPQQFINGINQGYKLLAWPA-DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
W + + I + Y++ W A D EA V + + + NL T YF
Sbjct: 816 VHW----EHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQ---EYSARLENLLPDTQYFI 868
Query: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITG 1004
V + G GPPS +T++ P + + + ++W L +TG
Sbjct: 869 EVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTG 928
Query: 1005 YQISWEVYGRNDSRLTHTLNSTTHEYKIQ-GLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
Y++ + G++D +L +TH++ I+ + Y ++V A + G G+V+ I S
Sbjct: 929 YKVLYRPDGQHDGKL-----YSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKI-S 982
Query: 1064 GVP 1066
G P
Sbjct: 983 GAP 985
Score = 120 bits (300), Expect = 2e-26
Identities = 95/373 (25%), Positives = 159/373 (42%), Gaps = 32/373 (8%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP L + ++ A S+ L W GSD SPI +T+Q + + +W+ +
Sbjct: 590 RGPPGPPGGLRIE--DIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI 647
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I A L P+ Y+ R+ ATN +G + S + + T P P V
Sbjct: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 707
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
+ I W P E G GY + ++ + G + T+ NP +
Sbjct: 708 RNRELTITWAPLSREYHYGNNFGYIVAFKPFD---GEEWKKVTVTNP----------DTG 754
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
+ V+ T + ++V + A+N G+ P S + + AP+ AP V V
Sbjct: 755 RYVHKDET--------MSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV 806
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
L++S++ V W+ + ++ Y+I YW A + E + E RL+NL
Sbjct: 807 KVLSSSEISVHWEHVLEKI----VESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLP 862
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
T+Y + + A N+AG GP SD + T +A P P + S + + ++W A +
Sbjct: 863 DTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSN 922
Query: 1830 -GILQGYRVVYEP 1841
+ GY+V+Y P
Sbjct: 923 ESTVTGYKVLYRP 935
Score = 92.0 bits (227), Expect = 6e-18
Identities = 85/359 (23%), Positives = 153/359 (42%), Gaps = 30/359 (8%)
Query: 972 PGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT----LNSTT 1027
PG G L +I TS+ ++W + + I+ Y I + +D + T +
Sbjct: 593 PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNM 652
Query: 1028 HEYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSGVPPDLPGAPSNLVISNISPR 1084
+ L Y V A +G G + ++ + G P++ APS++ R
Sbjct: 653 EAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNV--APSDVGGGGGRNR 710
Query: 1085 SATLQFRPGYDGKTSISRWIVEGQ-VGAIG-----DEEEWVTLYEEENEPDAQMLEIPNL 1138
T+ + P +SR G G I D EEW + + + + +
Sbjct: 711 ELTITWAP-------LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETM 763
Query: 1139 TPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLP 1198
+P T ++ ++K N G PYS + VI + Q P APT V V+ S + + + W +
Sbjct: 764 SPSTAFQVKVKAFNNKGDGPYSLVA-VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVL 822
Query: 1199 DSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAV 1258
+ Y+I+YW + + A +V E +E L +Y +++ A N+
Sbjct: 823 EKIVES------YQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSA 876
Query: 1259 GAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR 1317
G GP S+++ T+++ PS P +S+ S ++ ++TW V + GYK+L+R
Sbjct: 877 GCGPPSDMIEAFTKKAPPSQPPRIISS-VRSGSRYIITWDHVVALSNESTVTGYKVLYR 934
Score = 85.9 bits (211), Expect = 4e-16
Identities = 102/445 (22%), Positives = 172/445 (38%), Gaps = 56/445 (12%)
Query: 1355 AFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIA 1414
A T + N S L++ PGPP L ++R TSV + W + + I Y I
Sbjct: 574 AQTIVDNSSASADLVVR----GPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQ 629
Query: 1415 YRLASSSPHTFTTVE---VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEP-LEATVIT 1470
+ S + + + A DL P Y FR+ A G GEP + + I
Sbjct: 630 TKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIK 689
Query: 1471 TEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS 1530
T+ P + V R L + W P S F V P + +
Sbjct: 690 TDGAAPNVAPSD--VGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 747
Query: 1531 ISHEATACVV---DRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSA 1587
+++ T V + + P T++++++KA N+ GD +S + + QD P E P V
Sbjct: 748 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSL-VAVINSAQDAPSEAPTEVGV 806
Query: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
++S + + W + L +++ Y+I Y A +
Sbjct: 807 KVLSSSEISVHW----EHVLEKIVESYQIRY----------------------WAAHDKE 840
Query: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
+ V +S L +L +Y + + A N G P S +E F +A P+ P+
Sbjct: 841 EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI 900
Query: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNE-----TEKMKVLFLPEPV 1762
+ + + S+ +TWD S + GYK+ Y D Q++ T K + P+
Sbjct: 901 IS-SVRSGSRYIITWDHVVALSNESTVTGYKVLY-RPDGQHDGKLYSTHKHSI---EVPI 955
Query: 1763 VRLKNLTSHTKYLVSISAFNAAGDG 1787
R +Y+V + A + GDG
Sbjct: 956 PR------DGEYVVEVRAHSDGGDG 974
Score = 70.5 bits (171), Expect = 2e-11
Identities = 57/245 (23%), Positives = 98/245 (40%), Gaps = 8/245 (3%)
Query: 1241 ELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
+L WMEYE ++ A N +G G P R +T + P+ AP +V + ++ +TW
Sbjct: 659 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 718
Query: 1300 VPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALL---AGLRKFVLYELQVLAF 1356
+ + G GY + F K D E + N + + ++++V AF
Sbjct: 719 LSREYHYGNNFGYIVAF--KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAF 776
Query: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416
G+G S ++ +D P + + + + + W+ E I+ YQI Y
Sbjct: 777 NNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRYW 834
Query: 1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRER 1476
A V+V + +L P++ Y + A G G P + T+K
Sbjct: 835 AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP 894
Query: 1477 PAPPR 1481
PPR
Sbjct: 895 SQPPR 899
Score = 64.7 bits (156), Expect = 1e-09
Identities = 92/365 (25%), Positives = 143/365 (39%), Gaps = 29/365 (7%)
Query: 1266 VVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRA------K 1319
VVRG P P + E + +T + LTW+ D + I Y I + K
Sbjct: 588 VVRG------PPGPPGGLRIEDIRATSVALTWSR--GSDNHSPISKYTIQTKTILSDDWK 639
Query: 1320 DLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379
D +P I+ GN ++A L ++ YE +V+A +G G PS P +T AP
Sbjct: 640 DAKTDPP--IIEGN-MEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
Query: 1380 -PPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ 1436
P + R + I W P E G GY +A++ TV T R
Sbjct: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRY 756
Query: 1437 FTATD-LAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
+ ++P +A+ ++ A +G G VI + + P E+ V + S+
Sbjct: 757 VHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISV 816
Query: 1496 RLQWVPGSDGAS-PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLK 1554
+ V S IRY+ +E Q S S ++ L P T Y + +
Sbjct: 817 HWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSAR-----LENLLPDTQYFIEVG 871
Query: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGY 1614
A N G S EA T + P +PP +S+ + S +I W S + GY
Sbjct: 872 ACNSAGCGPPSDMIEAFTK-KAPPSQPPRIISSV-RSGSRYIITWDHVVALSNESTVTGY 929
Query: 1615 RIYYR 1619
++ YR
Sbjct: 930 KVLYR 934
Score = 48.5 bits (114), Expect = 7e-05
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1881 ARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEAR 1940
A+TI A++ G PG R + A+ + L W+ G +P + Y I+ +
Sbjct: 574 AQTIVDNSSASADLVVRGPPGPPGGLR--IEDIRATSVALTWSRGSDNHSPISKYTIQTK 631
Query: 1941 PSDEGLWDMFVKDIP--RSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSA 1998
W D P ++D L + YEFRVVA N G GEPS PS +
Sbjct: 632 TILSDDWKDAKTDPPIIEGNMEAARAVD-LIPWMEYEFRVVATNTLGRGEPSIPSNRIKT 690
Query: 1999 QVEAP 2003
AP
Sbjct: 691 DGAAP 695
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 281 bits (718), Expect = 7e-75
Identities = 254/1003 (25%), Positives = 427/1003 (42%), Gaps = 87/1003 (8%)
Query: 104 PYFKTEPG---LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSL- 159
P F+ +P P+ LEG ++ L C A S +KW ++ ++ S Y + +L
Sbjct: 41 PIFEEQPINTIYPEESLEG-KVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLV 99
Query: 160 -----QKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKT-VSQGRAAILNLL 213
++ DAG Y C+ N G + ++ + Y+ F ++ + V +G+ +L
Sbjct: 100 INNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCD 159
Query: 214 PITSYPRP-QVTWFREGHKI---IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNG 269
P +P W + + R L I SD G Y +
Sbjct: 160 PPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSIT 219
Query: 270 ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW 329
++ S FI L I T + IVV + + G + TLEC A PV D + W
Sbjct: 220 KSVFSKFIPL-IPIPERTTKPYPADIVVQFKDVYALMGQN-VTLECFALGNPVPD--IRW 275
Query: 330 KR--NGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA-LPGSAFEPARATAFLFIIEPP 386
++ + T+ + + G L I N D G Y CEA + G AR
Sbjct: 276 RKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARI---------- 325
Query: 387 YFTAEPESRISAEVEETVDIG------CQAMGVPLPTLQWYKDAISISRLQNPRYKVLAS 440
Y A PE + + VDIG C A G P+PT++W K+ + +
Sbjct: 326 YVQAFPEW-VEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------- 373
Query: 441 GGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTV--TDGMTAI 498
G LR+ + E++G++QC A N G I + L + +AP F P+ + G I
Sbjct: 374 GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVI 433
Query: 499 LRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANT 558
+ C+ APKP +W + L + S R ++ E G L+I + D G YTC+A N
Sbjct: 434 IECKPKAAPKPKFSWSKGTEWLVNSS----RILIWEDGSLEINNITRNDGGIYTCFAENN 489
Query: 559 EGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP 618
G N++ TL + + T I+ P + + G AT+ C A+ DP + L +VW + +
Sbjct: 490 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 549
Query: 619 SSTS-----RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQN 673
+ + +++ +G LLI G Y+C + N S A L V P P
Sbjct: 550 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGG 609
Query: 674 LLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVE----LSENNSPWKVHLSNVGPEMTGVT 729
L + + +V L+W R D +SPI Y ++ LS++ K + M
Sbjct: 610 LRI--EDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAAR 667
Query: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
L P Y+FRV A N +GRG+ S ++R+ P+ P ++ G N+ + + W
Sbjct: 668 AVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITW 727
Query: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTD--LIIWTQYEIQVAA 847
P H G GYI+ ++ E+++ +T+P+ + D + T ++++V A
Sbjct: 728 APLSREYHYGNNFGYIVAFKPFD-GEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKA 786
Query: 848 YNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL 907
+N G G +S + Q P+ P V + ++S+ I W + + I + Y++
Sbjct: 787 FNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW----EHVLEKIVESYQI 842
Query: 908 LAWPA-DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVW 966
W A D EA V + + + NL T YF V + G GPPS +
Sbjct: 843 RYWAAHDKEEAANRVQVTSQ---EYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAF 899
Query: 967 TQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYGRNDSRLTHTLN 1024
T++ P + + + ++W L +TGY++ + G++D +L
Sbjct: 900 TKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKL----- 954
Query: 1025 STTHEYKIQ-GLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVP 1066
+TH++ I+ + Y ++V A + G G+V+ I SG P
Sbjct: 955 YSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKI-SGAP 996
Score = 120 bits (300), Expect = 2e-26
Identities = 95/373 (25%), Positives = 159/373 (42%), Gaps = 32/373 (8%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP L + ++ A S+ L W GSD SPI +T+Q + + +W+ +
Sbjct: 601 RGPPGPPGGLRIE--DIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI 658
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I A L P+ Y+ R+ ATN +G + S + + T P P V
Sbjct: 659 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 718
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
+ I W P E G GY + ++ + G + T+ NP +
Sbjct: 719 RNRELTITWAPLSREYHYGNNFGYIVAFKPFD---GEEWKKVTVTNP----------DTG 765
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
+ V+ T + ++V + A+N G+ P S + + AP+ AP V V
Sbjct: 766 RYVHKDET--------MSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV 817
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
L++S++ V W+ + ++ Y+I YW A + E + E RL+NL
Sbjct: 818 KVLSSSEISVHWEHVLEKI----VESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLP 873
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
T+Y + + A N+AG GP SD + T +A P P + S + + ++W A +
Sbjct: 874 DTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSN 933
Query: 1830 -GILQGYRVVYEP 1841
+ GY+V+Y P
Sbjct: 934 ESTVTGYKVLYRP 946
Score = 92.0 bits (227), Expect = 6e-18
Identities = 85/359 (23%), Positives = 153/359 (42%), Gaps = 30/359 (8%)
Query: 972 PGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT----LNSTT 1027
PG G L +I TS+ ++W + + I+ Y I + +D + T +
Sbjct: 604 PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNM 663
Query: 1028 HEYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSGVPPDLPGAPSNLVISNISPR 1084
+ L Y V A +G G + ++ + G P++ APS++ R
Sbjct: 664 EAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNV--APSDVGGGGGRNR 721
Query: 1085 SATLQFRPGYDGKTSISRWIVEGQ-VGAIG-----DEEEWVTLYEEENEPDAQMLEIPNL 1138
T+ + P +SR G G I D EEW + + + + +
Sbjct: 722 ELTITWAP-------LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETM 774
Query: 1139 TPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLP 1198
+P T ++ ++K N G PYS + VI + Q P APT V V+ S + + + W +
Sbjct: 775 SPSTAFQVKVKAFNNKGDGPYSLVA-VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVL 833
Query: 1199 DSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAV 1258
+ Y+I+YW + + A +V E +E L +Y +++ A N+
Sbjct: 834 EKIVES------YQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSA 887
Query: 1259 GAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR 1317
G GP S+++ T+++ PS P +S+ S ++ ++TW V + GYK+L+R
Sbjct: 888 GCGPPSDMIEAFTKKAPPSQPPRIISS-VRSGSRYIITWDHVVALSNESTVTGYKVLYR 945
Score = 85.9 bits (211), Expect = 4e-16
Identities = 102/445 (22%), Positives = 172/445 (38%), Gaps = 56/445 (12%)
Query: 1355 AFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIA 1414
A T + N S L++ PGPP L ++R TSV + W + + I Y I
Sbjct: 585 AQTIVDNSSASADLVVR----GPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQ 640
Query: 1415 YRLASSSPHTFTTVE---VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEP-LEATVIT 1470
+ S + + + A DL P Y FR+ A G GEP + + I
Sbjct: 641 TKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIK 700
Query: 1471 TEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS 1530
T+ P + V R L + W P S F V P + +
Sbjct: 701 TDGAAPNVAPSD--VGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 758
Query: 1531 ISHEATACVV---DRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSA 1587
+++ T V + + P T++++++KA N+ GD +S + + QD P E P V
Sbjct: 759 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSL-VAVINSAQDAPSEAPTEVGV 817
Query: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
++S + + W + L +++ Y+I Y A +
Sbjct: 818 KVLSSSEISVHW----EHVLEKIVESYQIRY----------------------WAAHDKE 851
Query: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
+ V +S L +L +Y + + A N G P S +E F +A P+ P+
Sbjct: 852 EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI 911
Query: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNE-----TEKMKVLFLPEPV 1762
+ + + S+ +TWD S + GYK+ Y D Q++ T K + P+
Sbjct: 912 IS-SVRSGSRYIITWDHVVALSNESTVTGYKVLY-RPDGQHDGKLYSTHKHSI---EVPI 966
Query: 1763 VRLKNLTSHTKYLVSISAFNAAGDG 1787
R +Y+V + A + GDG
Sbjct: 967 PR------DGEYVVEVRAHSDGGDG 985
Score = 70.5 bits (171), Expect = 2e-11
Identities = 57/245 (23%), Positives = 98/245 (40%), Gaps = 8/245 (3%)
Query: 1241 ELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
+L WMEYE ++ A N +G G P R +T + P+ AP +V + ++ +TW
Sbjct: 670 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 729
Query: 1300 VPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALL---AGLRKFVLYELQVLAF 1356
+ + G GY + F K D E + N + + ++++V AF
Sbjct: 730 LSREYHYGNNFGYIVAF--KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAF 787
Query: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416
G+G S ++ +D P + + + + + W+ E I+ YQI Y
Sbjct: 788 NNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRYW 845
Query: 1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRER 1476
A V+V + +L P++ Y + A G G P + T+K
Sbjct: 846 AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP 905
Query: 1477 PAPPR 1481
PPR
Sbjct: 906 SQPPR 910
Score = 64.7 bits (156), Expect = 1e-09
Identities = 92/365 (25%), Positives = 143/365 (39%), Gaps = 29/365 (7%)
Query: 1266 VVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRA------K 1319
VVRG P P + E + +T + LTW+ D + I Y I + K
Sbjct: 599 VVRG------PPGPPGGLRIEDIRATSVALTWSR--GSDNHSPISKYTIQTKTILSDDWK 650
Query: 1320 DLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379
D +P I+ GN ++A L ++ YE +V+A +G G PS P +T AP
Sbjct: 651 DAKTDPP--IIEGN-MEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 707
Query: 1380 -PPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ 1436
P + R + I W P E G GY +A++ TV T R
Sbjct: 708 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRY 767
Query: 1437 FTATD-LAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
+ ++P +A+ ++ A +G G VI + + P E+ V + S+
Sbjct: 768 VHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISV 827
Query: 1496 RLQWVPGSDGAS-PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLK 1554
+ V S IRY+ +E Q S S ++ L P T Y + +
Sbjct: 828 HWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSAR-----LENLLPDTQYFIEVG 882
Query: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGY 1614
A N G S EA T + P +PP +S+ + S +I W S + GY
Sbjct: 883 ACNSAGCGPPSDMIEAFTK-KAPPSQPPRIISSV-RSGSRYIITWDHVVALSNESTVTGY 940
Query: 1615 RIYYR 1619
++ YR
Sbjct: 941 KVLYR 945
Score = 48.5 bits (114), Expect = 7e-05
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1881 ARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEAR 1940
A+TI A++ G PG R + A+ + L W+ G +P + Y I+ +
Sbjct: 585 AQTIVDNSSASADLVVRGPPGPPGGLR--IEDIRATSVALTWSRGSDNHSPISKYTIQTK 642
Query: 1941 PSDEGLWDMFVKDIP--RSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSA 1998
W D P ++D L + YEFRVVA N G GEPS PS +
Sbjct: 643 TILSDDWKDAKTDPPIIEGNMEAARAVD-LIPWMEYEFRVVATNTLGRGEPSIPSNRIKT 701
Query: 1999 QVEAP 2003
AP
Sbjct: 702 DGAAP 706
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 274 bits (700), Expect = 8e-73
Identities = 268/1039 (25%), Positives = 431/1039 (41%), Gaps = 75/1039 (7%)
Query: 92 HLLRALAQD---DVAPYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELT 146
H A QD D P F EP + + ++ L C G+ ++W+R+ +E+
Sbjct: 84 HSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEID 143
Query: 147 TYSSEYKYII---------PSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMD-T 196
S+Y+Y + PS K D+G Y+C+ N +G++L R++ +Q AY+G+F T
Sbjct: 144 L-ESDYRYSLIDGTFIISNPSEAK-DSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT 201
Query: 197 DQRKTVSQGRAAILNLLPITSYPRPQVTW-FREGHKIIP--SNRIAITLENQLVILATTT 253
+V +G+ +L P P +W F E + S R L I T
Sbjct: 202 RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQT 261
Query: 254 SDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTL 313
SD G+Y N SP L++ D G P I V A + +
Sbjct: 262 SDVGSYICLVKNTVTNARVLSPPTPLTLRND-GVMGEYEPKIEVHFPFTVTAAKGTTVKM 320
Query: 314 ECIASARPVEDLSVTW-KRNG-VRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAF 371
EC A PV ++TW K NG + + L L I N D G Y C A ++
Sbjct: 321 ECFALGNPVP--TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE---NSR 375
Query: 372 EPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQ 431
L + P++ E + + + C+A G P PT +W K+ + +S
Sbjct: 376 GKNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS--- 431
Query: 432 NPRYKV-LASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTT 490
P+ +V + +G L I + D+G++QC A N+ G I L + AP F + T
Sbjct: 432 -PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKT 490
Query: 491 --VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA 548
VT ++ C+ G+PKP I+WK+ + + R +L G L+I D
Sbjct: 491 IIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASKSDE 546
Query: 549 GNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV 608
G Y C N GS A+L+V T I P+ + G + L+C A HD + + +
Sbjct: 547 GKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFY 606
Query: 609 WKKDNVALTPSST-----SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLE 663
W + S L+I G Y C + + + S A L
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAEL- 665
Query: 664 VIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGP 723
++ P P +++ + S A LSW D +SPI Y ++ S + V
Sbjct: 666 LVRGPPGPPGIVIVEEITESTAT-LSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPE 724
Query: 724 EMTGVTVSG----LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779
+TG S L P Y+FRV A N +G G S + + E P P N+
Sbjct: 725 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
Query: 780 RTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII-- 837
+++ W+P E NG GYI+ +R G G ++++ +TS E + + D +
Sbjct: 785 GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRG-WKEKMVTSSEASKFIYRDESVPP 843
Query: 838 WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQF 897
T +E++V YN G G FS+ V + +G P+A P +V+ +V+ + I W +
Sbjct: 844 LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL 903
Query: 898 INGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPG 955
G QG+++ W E A TV T + + +T L+ T Y +V + G
Sbjct: 904 --GRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI----LTGLEGNTLYHFTVRAYNGAG 957
Query: 956 DGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYG 1013
GPPS+ T++ P E + + + W+ PL + GY++ + G
Sbjct: 958 YGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG 1017
Query: 1014 RNDSRLTHTLNSTTHEYKIQGLSSLT---TYTIDVAAVTAVGTGLVTSS-TISSGVPPDL 1069
++S++ T K+Q + L Y I+V A + G G +S + S +
Sbjct: 1018 HSNSQVIET-------QKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 1070
Query: 1070 PGAPSNLVISNISPRSATL 1088
A S L + S S TL
Sbjct: 1071 TSAQSTLHSLSTSSSSVTL 1089
Score = 126 bits (316), Expect = 3e-28
Identities = 110/407 (27%), Positives = 186/407 (45%), Gaps = 38/407 (9%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTL--YEEEN 1126
PG P +++ I+ +ATL + P D + IS + ++ + ++G W T+ E
Sbjct: 671 PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLG----WQTVKTVPEII 726
Query: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
D + +L P+ Y FR+ N +G S SR+I+T +A P APT+V+ R+
Sbjct: 727 TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR 786
Query: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTI 1239
L + W P+ + NG E GY + + W+ + +S+ A S + R+ ++
Sbjct: 787 RHELVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEA---SKFIYRDESV 841
Query: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
L +E+++ +N G GP+S++V + E PSAAP +V A +VS ++IL+ W
Sbjct: 842 PPL---TPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKH 898
Query: 1300 VPEQ--DQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS-ALLAGLRKFVLYELQVLAF 1356
+ E G +GY KD++ E + V+ +S +L GL LY V A+
Sbjct: 899 IKESLGRPQGFEVGY-----WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 953
Query: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIA 1414
G G PS+ + K P L + E + + V + W+P P ++GY++
Sbjct: 954 NGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLANESEVVGYKVF 1012
Query: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
YR S +V T + L YI + A + G G
Sbjct: 1013 YRQEGHS-----NSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDG 1054
Score = 124 bits (312), Expect = 8e-28
Identities = 102/372 (27%), Positives = 166/372 (44%), Gaps = 32/372 (8%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP ++V E+T + L W P +D SPI + +Q R WQT +
Sbjct: 668 RGPPGPPGIVIVE--EITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEI 725
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I+ + + + L P+ Y+ R+ ATN IG D S+ + + T + VP P +VS
Sbjct: 726 ITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSG 785
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
++I W+P +E NG GY + +R +GT K +T+ +
Sbjct: 786 RRHELVIAWEPVSEEFQNGEGFGYIVAFRP------NGTRGWKEKM-------VTSSEAS 832
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
K + + + +EV + YN G+ P S V + E P+ AP +V+
Sbjct: 833 KFIYRDES--------VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKA 884
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
T ++ S++ V W + G QG+++ YW+ Q +T + E V L L
Sbjct: 885 TSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEG 942
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGE--PAA 1827
+T Y ++ A+N AG GP S T ++ P APS L + E + +++ W P A
Sbjct: 943 NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLA 1001
Query: 1828 ANGILQGYRVVY 1839
+ GY+V Y
Sbjct: 1002 NESEVVGYKVFY 1013
Score = 102 bits (255), Expect = 3e-21
Identities = 105/427 (24%), Positives = 178/427 (41%), Gaps = 54/427 (12%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVE--VGATV 1434
PGPP ++ E+ ++ + W P + + I Y + R S T TV + +
Sbjct: 671 PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDM 730
Query: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEAT--VITTEKRERPAPPRELLVPQAEVTA 1492
A DL P Y FR+ A G G+P + + T E + AP V
Sbjct: 731 ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGRR 787
Query: 1493 RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQTYSSSISHEATACVVDR-LRPFTSY 1549
L + W P S+ F V P G W+ + S + D + P T +
Sbjct: 788 HELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 847
Query: 1550 KLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNG 1609
++++ N+ GD FS + + + + P P V AT + S +L+ W+ + ESL G
Sbjct: 848 EVKVGVYNNKGDGPFS-QIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-ESL-G 904
Query: 1610 LLQGYRI-YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668
QG+ + Y++++E E + +TV + + LT L+
Sbjct: 905 RPQGFEVGYWKDMEQE-----------------------DTAETVKTRGNESFVILTGLE 941
Query: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728
Y + AYN G P S+ V ++ P+ AP N++ SQ+ + W+P P
Sbjct: 942 GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ-QGSQVSLGWEPVIPL 1000
Query: 1729 SQNGNIQGYKIYYWEADSQN----ETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNA 1783
+ + GYK++Y + N ET+K++ V+ LP+ V Y++ + A++
Sbjct: 1001 ANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGV----------YIIEVRAYSE 1050
Query: 1784 AGDGPKS 1790
GDG S
Sbjct: 1051 GGDGTAS 1057
Score = 96.3 bits (238), Expect = 3e-19
Identities = 104/442 (23%), Positives = 174/442 (39%), Gaps = 50/442 (11%)
Query: 1173 PDVAPTSVTVRTASETSLRLRWVPLPD-----SQYN---GNPESVGYRIKYWRSDLQSSA 1224
P P V V +E++ L W P D S YN +P S+G++
Sbjct: 670 PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV--------KT 721
Query: 1225 VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENV 1283
V ++++ +E ++ L W+EYE ++ A N +G G S R RT E+VP AP NV
Sbjct: 722 VPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 780
Query: 1284 SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343
S + ++++ W V E+ QNG GY + FR RG + +
Sbjct: 781 SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG---------TRGWKEKMVTSSEA 831
Query: 1344 RKFVL----------YELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS 1393
KF+ +E++V + G+G S +++ + + P + V ++
Sbjct: 832 SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 891
Query: 1394 VRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453
+ + W+ +E G G+++ Y T TV+ T L + Y F +
Sbjct: 892 ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 951
Query: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1513
A G+G P TT+K P L + E + L W P A+
Sbjct: 952 AYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQVSLGWEPVIPLANESEVVG 1008
Query: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573
+V R E + S I + VV L Y + ++A ++ GD SS+
Sbjct: 1009 YKV--FYRQEGHSNSQVIETQKLQAVVP-LPDAGVYIIEVRAYSEGGDGTASSQIR---- 1061
Query: 1574 LQDVPGEPPGSVSATPHTTSSV 1595
VP G +++ T S+
Sbjct: 1062 ---VPSYSGGKITSAQSTLHSL 1080
Score = 54.3 bits (129), Expect = 1e-06
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959
G PG P V+V + + S TL W+ +P + Y ++AR W VK +P T
Sbjct: 669 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-VKTVPEIIT 727
Query: 1960 S---YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
+++D L V YEFRVVA N G G+PS PS + P
Sbjct: 728 GDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773
Score = 46.2 bits (108), Expect = 4e-04
Identities = 87/337 (25%), Positives = 127/337 (37%), Gaps = 52/337 (15%)
Query: 1701 PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPE 1760
P P V V +T S ++W P + I Y + +A S V +PE
Sbjct: 670 PPGPPGIVIVEEITESTATLSWSPAA--DNHSPISSYNL---QARSPFSLGWQTVKTVPE 724
Query: 1761 PVV------RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQG-RTHQAAPG-APSFLAFSE 1812
+ +L +Y + A N G G S P + RT++A P AP+ ++
Sbjct: 725 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
Query: 1813 ITSTTLNVSWGEPAAA---NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW-QRWLKVRD 1868
L ++W EP + NG GY V + P K+VT + R V
Sbjct: 785 GRRHELVIAW-EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPP 843
Query: 1869 LTKGVTYFFRVQARTITY---GPELQANITAGPAEGSPGS-PRDVLVTK-SASELTLQWT 1923
LT F V+ GP Q + AEG P + P DV T S SE+ + W
Sbjct: 844 LTP-----FEVKVGVYNNKGDGPFSQIVVICS-AEGEPSAAPTDVKATSVSVSEILVAWK 897
Query: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLS---------LDKLRQGVTY 1974
++ E+ +G + KD+ + T+ T+ L L Y
Sbjct: 898 -----------HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLY 946
Query: 1975 EFRVVAVNEAGYGEPS---NPSTAVSAQVEAPFYEEW 2008
F V A N AGYG PS + +T S +AP W
Sbjct: 947 HFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW 983
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 274 bits (700), Expect = 8e-73
Identities = 269/1045 (25%), Positives = 436/1045 (41%), Gaps = 74/1045 (7%)
Query: 84 WALLALQLHLLRALAQD-DVAPYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWMR 140
W L+ L L + L++ D P F EP + + ++ L C G+ ++W+R
Sbjct: 5 WKLM-LFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLR 63
Query: 141 DDSELTTYSSEYKYII---------PSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMG 191
+ +E+ S+Y+Y + PS K D+G Y+C+ N +G++L R++ +Q AY+G
Sbjct: 64 NGTEIDL-ESDYRYSLIDGTFIISNPSEAK-DSGHYQCLATNTVGSILSREATLQFAYLG 121
Query: 192 SFMD-TDQRKTVSQGRAAILNLLPITSYPRPQVTW-FREGHKIIP--SNRIAITLENQLV 247
+F T +V +G+ +L P P +W F E + S R L
Sbjct: 122 NFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLY 181
Query: 248 ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAG 307
I TSD G+Y N SP L++ D G P I V A
Sbjct: 182 ISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRND-GVMGEYEPKIEVHFPFTVTAAK 240
Query: 308 SSETTLECIASARPVEDLSVTW-KRNG-VRITSGLHSFGRRLTISNPTSADTGPYVCEAA 365
+ +EC A PV ++TW K NG + + L L I N D G Y C A
Sbjct: 241 GTTVKMECFALGNPVP--TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
Query: 366 LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425
++ L + P++ E + + + C+A G P PT +W K+ +
Sbjct: 299 ---NSRGKNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGV 354
Query: 426 SISRLQNPRYKV-LASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQ 484
+S P+ +V + +G L I + D+G++QC A N+ G I L + AP F
Sbjct: 355 PLS----PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL 410
Query: 485 RPVDTT--VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAP 542
+ T VT ++ C+ G+PKP I+WK+ + + R +L G L+I
Sbjct: 411 NQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILN 466
Query: 543 VFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPR 602
D G Y C N GS A+L+V T I P+ + G + L+C A HD
Sbjct: 467 ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 526
Query: 603 VSLRYVWKKDNVALTPSST-----SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDS 657
+ + + W + S L+I G Y C + + + S
Sbjct: 527 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS 586
Query: 658 RMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVH 717
A L ++ P P +++ + S A LSW D +SPI Y ++ S
Sbjct: 587 DEAEL-LVRGPPGPPGIVIVEEITESTAT-LSWSPAADNHSPISSYNLQARSPFSLGWQT 644
Query: 718 LSNVGPEMTGVTVSG----LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPK 773
+ V +TG S L P Y+FRV A N +G G S + + E P P
Sbjct: 645 VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT 704
Query: 774 NIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVT 833
N+ +++ W+P E NG GYI+ +R G G ++++ +TS E + +
Sbjct: 705 NVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRG-WKEKMVTSSEASKFIYR 763
Query: 834 DLII--WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWN 891
D + T +E++V YN G G FS+ V + +G P+A P +V+ +V+ + I W
Sbjct: 764 DESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK 823
Query: 892 PPPQQFINGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVL 949
+ G QG+++ W E A TV T + + +T L+ T Y +V
Sbjct: 824 HIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI----LTGLEGNTLYHFTVR 877
Query: 950 CFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQI 1007
+ G GPPS+ T++ P E + + + W+ PL + GY++
Sbjct: 878 AYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKV 937
Query: 1008 SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLT---TYTIDVAAVTAVGTGLVTSS-TISS 1063
+ G ++S++ T K+Q + L Y I+V A + G G +S + S
Sbjct: 938 FYRQEGHSNSQVIET-------QKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPS 990
Query: 1064 GVPPDLPGAPSNLVISNISPRSATL 1088
+ A S L + S S TL
Sbjct: 991 YSGGKITSAQSTLHSLSTSSSSVTL 1015
Score = 126 bits (316), Expect = 3e-28
Identities = 110/407 (27%), Positives = 186/407 (45%), Gaps = 38/407 (9%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTL--YEEEN 1126
PG P +++ I+ +ATL + P D + IS + ++ + ++G W T+ E
Sbjct: 597 PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLG----WQTVKTVPEII 652
Query: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
D + +L P+ Y FR+ N +G S SR+I+T +A P APT+V+ R+
Sbjct: 653 TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR 712
Query: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTI 1239
L + W P+ + NG E GY + + W+ + +S+ A S + R+ ++
Sbjct: 713 RHELVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEA---SKFIYRDESV 767
Query: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
L +E+++ +N G GP+S++V + E PSAAP +V A +VS ++IL+ W
Sbjct: 768 PPL---TPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKH 824
Query: 1300 VPEQ--DQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS-ALLAGLRKFVLYELQVLAF 1356
+ E G +GY KD++ E + V+ +S +L GL LY V A+
Sbjct: 825 IKESLGRPQGFEVGY-----WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 879
Query: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIA 1414
G G PS+ + K P L + E + + V + W+P P ++GY++
Sbjct: 880 NGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLANESEVVGYKVF 938
Query: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
YR S +V T + L YI + A + G G
Sbjct: 939 YRQEGHS-----NSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDG 980
Score = 124 bits (312), Expect = 8e-28
Identities = 102/372 (27%), Positives = 166/372 (44%), Gaps = 32/372 (8%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP ++V E+T + L W P +D SPI + +Q R WQT +
Sbjct: 594 RGPPGPPGIVIVE--EITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEI 651
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I+ + + + L P+ Y+ R+ ATN IG D S+ + + T + VP P +VS
Sbjct: 652 ITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSG 711
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
++I W+P +E NG GY + +R +GT K +T+ +
Sbjct: 712 RRHELVIAWEPVSEEFQNGEGFGYIVAFRP------NGTRGWKEKM-------VTSSEAS 758
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
K + + + +EV + YN G+ P S V + E P+ AP +V+
Sbjct: 759 KFIYRDES--------VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKA 810
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
T ++ S++ V W + G QG+++ YW+ Q +T + E V L L
Sbjct: 811 TSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEG 868
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGE--PAA 1827
+T Y ++ A+N AG GP S T ++ P APS L + E + +++ W P A
Sbjct: 869 NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLA 927
Query: 1828 ANGILQGYRVVY 1839
+ GY+V Y
Sbjct: 928 NESEVVGYKVFY 939
Score = 102 bits (255), Expect = 3e-21
Identities = 105/427 (24%), Positives = 178/427 (41%), Gaps = 54/427 (12%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVE--VGATV 1434
PGPP ++ E+ ++ + W P + + I Y + R S T TV + +
Sbjct: 597 PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDM 656
Query: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEAT--VITTEKRERPAPPRELLVPQAEVTA 1492
A DL P Y FR+ A G G+P + + T E + AP V
Sbjct: 657 ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGRR 713
Query: 1493 RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQTYSSSISHEATACVVDR-LRPFTSY 1549
L + W P S+ F V P G W+ + S + D + P T +
Sbjct: 714 HELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 773
Query: 1550 KLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNG 1609
++++ N+ GD FS + + + + P P V AT + S +L+ W+ + ESL G
Sbjct: 774 EVKVGVYNNKGDGPFS-QIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-ESL-G 830
Query: 1610 LLQGYRI-YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668
QG+ + Y++++E E + +TV + + LT L+
Sbjct: 831 RPQGFEVGYWKDMEQE-----------------------DTAETVKTRGNESFVILTGLE 867
Query: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728
Y + AYN G P S+ V ++ P+ AP N++ SQ+ + W+P P
Sbjct: 868 GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ-QGSQVSLGWEPVIPL 926
Query: 1729 SQNGNIQGYKIYYWEADSQN----ETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNA 1783
+ + GYK++Y + N ET+K++ V+ LP+ V Y++ + A++
Sbjct: 927 ANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGV----------YIIEVRAYSE 976
Query: 1784 AGDGPKS 1790
GDG S
Sbjct: 977 GGDGTAS 983
Score = 96.3 bits (238), Expect = 3e-19
Identities = 104/442 (23%), Positives = 174/442 (39%), Gaps = 50/442 (11%)
Query: 1173 PDVAPTSVTVRTASETSLRLRWVPLPD-----SQYN---GNPESVGYRIKYWRSDLQSSA 1224
P P V V +E++ L W P D S YN +P S+G++
Sbjct: 596 PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV--------KT 647
Query: 1225 VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENV 1283
V ++++ +E ++ L W+EYE ++ A N +G G S R RT E+VP AP NV
Sbjct: 648 VPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 706
Query: 1284 SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343
S + ++++ W V E+ QNG GY + FR RG + +
Sbjct: 707 SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG---------TRGWKEKMVTSSEA 757
Query: 1344 RKFVL----------YELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS 1393
KF+ +E++V + G+G S +++ + + P + V ++
Sbjct: 758 SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 817
Query: 1394 VRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453
+ + W+ +E G G+++ Y T TV+ T L + Y F +
Sbjct: 818 ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 877
Query: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1513
A G+G P TT+K P L + E + L W P A+
Sbjct: 878 AYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQVSLGWEPVIPLANESEVVG 934
Query: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573
+V R E + S I + VV L Y + ++A ++ GD SS+
Sbjct: 935 YKV--FYRQEGHSNSQVIETQKLQAVVP-LPDAGVYIIEVRAYSEGGDGTASSQIR---- 987
Query: 1574 LQDVPGEPPGSVSATPHTTSSV 1595
VP G +++ T S+
Sbjct: 988 ---VPSYSGGKITSAQSTLHSL 1006
Score = 54.3 bits (129), Expect = 1e-06
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959
G PG P V+V + + S TL W+ +P + Y ++AR W VK +P T
Sbjct: 595 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-VKTVPEIIT 653
Query: 1960 S---YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
+++D L V YEFRVVA N G G+PS PS + P
Sbjct: 654 GDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699
Score = 46.2 bits (108), Expect = 4e-04
Identities = 87/337 (25%), Positives = 127/337 (37%), Gaps = 52/337 (15%)
Query: 1701 PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPE 1760
P P V V +T S ++W P + I Y + +A S V +PE
Sbjct: 596 PPGPPGIVIVEEITESTATLSWSPAA--DNHSPISSYNL---QARSPFSLGWQTVKTVPE 650
Query: 1761 PVV------RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQG-RTHQAAPG-APSFLAFSE 1812
+ +L +Y + A N G G S P + RT++A P AP+ ++
Sbjct: 651 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 710
Query: 1813 ITSTTLNVSWGEPAAA---NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW-QRWLKVRD 1868
L ++W EP + NG GY V + P K+VT + R V
Sbjct: 711 GRRHELVIAW-EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPP 769
Query: 1869 LTKGVTYFFRVQARTITY---GPELQANITAGPAEGSPGS-PRDVLVTK-SASELTLQWT 1923
LT F V+ GP Q + AEG P + P DV T S SE+ + W
Sbjct: 770 LTP-----FEVKVGVYNNKGDGPFSQIVVICS-AEGEPSAAPTDVKATSVSVSEILVAWK 823
Query: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLS---------LDKLRQGVTY 1974
++ E+ +G + KD+ + T+ T+ L L Y
Sbjct: 824 -----------HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLY 872
Query: 1975 EFRVVAVNEAGYGEPS---NPSTAVSAQVEAPFYEEW 2008
F V A N AGYG PS + +T S +AP W
Sbjct: 873 HFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW 909
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 272 bits (695), Expect = 3e-72
Identities = 296/1175 (25%), Positives = 480/1175 (40%), Gaps = 115/1175 (9%)
Query: 88 ALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNR--LVLTCLAEGSWPLEFKWMRD---- 141
AL++ L L +D V P T+ P+ ++ R +V+ C A+G P F W R+
Sbjct: 29 ALEVPLDPKLLEDLVQPPTITQQS-PKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHF 87
Query: 142 ----DSELTTYSSEYKYIIPSLQKLDA----GFYRCVVRNRMGALLQRKSEVQVAYMGSF 193
D +T II + + A G Y+C RN GA + + + V S
Sbjct: 88 DIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVS--NNIVVRPSRSP 145
Query: 194 MDTDQRK---TVSQGRAAILNLLPITSYPRPQVTWFREGHKIIP-SNRIAITLENQLVIL 249
+ T ++ T+ G++ +L P P P + W + +P S R++ L L
Sbjct: 146 LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFS 205
Query: 250 ATTTSDAGAYYV--------QAVNEKN---------GENKTSPFIHLSIARDVGTPETMA 292
D Y+ Q + +K E + +LS G +
Sbjct: 206 NVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRE 265
Query: 293 --PTIVVPPGNRS--VVAGSSETTLECIASARPVEDLSVTW-KRNGV--RITSGLHSFGR 345
PT + P GN S + +LECIA P + W K +G+ + + +F +
Sbjct: 266 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTP--IIYWAKEDGMLPKNRTVYKNFEK 323
Query: 346 RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVD 405
L I + + AD+G Y C A +A T + + PY+ P++ + + E+
Sbjct: 324 TLQIIHVSEADSGNYQCIAK---NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTL 380
Query: 406 IGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGG 465
I C+A G P P + W + + I + + + + ++ S ++QC ASNE G
Sbjct: 381 I-CRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439
Query: 466 EIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGS 524
+ + +++V P + T V A+L C G+P P I W + A GS
Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKG----AKGS 495
Query: 525 -VRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDH 583
+ ++L E+G L+I G YTC A N G L + + T IV PE
Sbjct: 496 ALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYA 555
Query: 584 VVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIG 643
VV +G+ + C HD +SL +W KDN L S R V+KD L+++ D G
Sbjct: 556 VVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL--PSDERFTVDKD-HLVVADVSDDDSG 612
Query: 644 DYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPN--------SSHSHAVVLSWVRPFD 695
Y+C + + S A L V+ +P + PN +V LSW D
Sbjct: 613 TYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDD 672
Query: 696 GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSG---LTPARTYQFRVCAVNEVGRG 752
NSPI +I+E + + K L + E++G + L+P Y FRV AVN +G+
Sbjct: 673 NNSPITKFIIEYED--AMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKS 730
Query: 753 QYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG 812
S + + + P P + G ++++ W+P E NG Y + +R
Sbjct: 731 LPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQK- 789
Query: 813 LPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAP 872
G+ + ++ V+ +V+ + Y I+V A N G V ++ + +P
Sbjct: 790 -DGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVA 848
Query: 873 PQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAP---DFHG 929
P NV+ VNST + W+P P + I G QGY++ W + I F G
Sbjct: 849 PGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQG 908
Query: 930 VH-HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSL 988
HG + L+ F+ Y +V G+GP S ++ T E P A L SL
Sbjct: 909 SKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSL 968
Query: 989 KVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLN--------STTHEYKIQGLSSLTT 1040
+ W P NGI+T Y + ++ TH L + + ++ L+ T
Sbjct: 969 TLEWDPPSHPNGILTEYTLKYQPINS-----THELGPLVDLKIPANKTRWTLKNLNFSTR 1023
Query: 1041 YTIDVAAVTAVGTG------LVTSSTISSGVPPDLPGAPSNLV---ISNISPRSATLQFR 1091
Y A T+ G+G VT+ + +PPD+ V ISN++ +A
Sbjct: 1024 YKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYAN 1083
Query: 1092 PG--YDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMK 1149
Y+G ++ ++ + G G +EEW +E + L P T Y+ R
Sbjct: 1084 ISWEYEGPEHVNFYV---EYGVAGSKEEW---RKEIVNGSRSFFGLKGLMPGTAYKVR-- 1135
Query: 1150 QVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRT 1184
V VG S + S V +T P +A V + T
Sbjct: 1136 -VGAVGDSGFVSSEDVFET---GPAMASRQVDIAT 1166
Score = 176 bits (445), Expect = 3e-43
Identities = 168/688 (24%), Positives = 288/688 (41%), Gaps = 72/688 (10%)
Query: 1477 PAPPREL-LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPR--GEWQTYSSSISH 1533
P PP +L L Q + +S++L W PG D SPI F ++ + G W +
Sbjct: 647 PNPPFDLELTDQLD---KSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGT 703
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ TA + +L P+ +Y R+ A N IG S S +E T P + P +V
Sbjct: 704 QTTAQL--KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPD 761
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
+++I W+P NG Y++ +R+ + G + T + + A S V
Sbjct: 762 NLVITWKPLNGFESNGPGLQYKVSWRQKD-----GDDEWT--------SVVVANVSKYIV 808
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ + T + Y + + A N +G +P A V GE P +AP NV+V +
Sbjct: 809 SGTPT-----------FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVV 857
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK----MKVLFLPEPVVR--LKN 1767
++ EV WDP P +S G++QGY+IYYW+ S ++ + K+L L
Sbjct: 858 NSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPG 917
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L + Y +++ N G+GP S + T + P APS L T +L + W P+
Sbjct: 918 LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSH 977
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRW-LKVRDLTKGVTYFFRVQ------ 1880
NGIL Y + Y+P+ + +V +++ N RW LK + + ++F Q
Sbjct: 978 PNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1037
Query: 1881 -------ARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTT 1933
T+ L ++ AG + +PR +T +A+E + + G
Sbjct: 1038 SQITEEAVTTVDEAGILPPDVGAGKVQAV--NPRISNLTAAAAETYANISWEYEGPEHVN 1095
Query: 1934 GYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGY--GEPSN 1991
YV + W K+I + S+ L L G Y+ RV AV ++G+ E
Sbjct: 1096 FYVEYGVAGSKEEWR---KEIVNGSRSF-FGLKGLMPGTAYKVRVGAVGDSGFVSSEDVF 1151
Query: 1992 PSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY-----KNCSTGKG 2046
+ A + + WF+ +M +L++++L++ + + KY ++
Sbjct: 1152 ETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPE 1211
Query: 2047 ISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYN 2106
I M+E D+G F + H +K + S L E + ++N
Sbjct: 1212 IQPMKE----DDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFN 1267
Query: 2107 --GAVLTESVSLKEKS-ADASESEATDS 2131
G+ + + KEK A+ +ES S
Sbjct: 1268 EDGSFIGQYSGKKEKEPAEGNESSEAPS 1295
Score = 154 bits (388), Expect = 1e-36
Identities = 140/554 (25%), Positives = 243/554 (43%), Gaps = 43/554 (7%)
Query: 1042 TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSIS 1101
T+D + +AV + V + T + D+P P +L +++ +S L + PG D + I+
Sbjct: 621 TLDSVSASAVLS--VVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPIT 678
Query: 1102 RWIVEGQVGAIGDEEEWVTLYEEENEPDA-QMLEIPNLTPYTHYRFRMKQVNIVGPSPYS 1160
++I+E + D L+ + E Q L+PY +Y FR+ VN +G S S
Sbjct: 679 KFIIEYE-----DAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPS 733
Query: 1161 PSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL 1220
+S T + PD PT+V + +L + W PL + NG + Y++ + + D
Sbjct: 734 EASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNG--PGLQYKVSWRQKDG 791
Query: 1221 QSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAP 1280
+ VV++ ++ + ++ Y +++QA N +G P VV G + E +P AP
Sbjct: 792 DDEWTSVVVAN--VSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAP 849
Query: 1281 ENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILF-RAKDLDPEPRSHI------VRGN 1333
NV V+ST + W VP + G + GY+I + + + R HI +G+
Sbjct: 850 GNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGS 909
Query: 1334 HTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS 1393
T +L GL F Y L V G G P++P + T + P P L L S
Sbjct: 910 KTH-GMLPGLEPFSHYTLNVRVVNGKGEG-PASPDRVFNTPEGVPSAPSSLKIVNPTLDS 967
Query: 1394 VRIVWQPPEEPNGIILGYQIAYRLASSSPH--TFTTVEVGATVRQFTATDLAPESAYIFR 1451
+ + W PP PNGI+ Y + Y+ +S+ +++ A ++T +L + Y F
Sbjct: 968 LTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFY 1027
Query: 1452 LSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGS-------- 1503
A+T G G + +TT PP V +V A + R+ + +
Sbjct: 1028 FYAQTSAGSGSQITEEAVTTVDEAGILPPD---VGAGKVQAVNPRISNLTAAAAETYANI 1084
Query: 1504 ----DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDI 1559
+G + ++ + EW+ ++ + + L P T+YK+R+ A +
Sbjct: 1085 SWEYEGPEHVNFYVEYGVAGSKEEWR--KEIVNGSRSFFGLKGLMPGTAYKVRVGA---V 1139
Query: 1560 GDSDFSSETEAVTT 1573
GDS F S + T
Sbjct: 1140 GDSGFVSSEDVFET 1153
Score = 109 bits (273), Expect = 3e-23
Identities = 131/511 (25%), Positives = 204/511 (39%), Gaps = 43/511 (8%)
Query: 1376 DAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP---HTFTTVEVGA 1432
D P PP L + SV++ W P ++ N I + I Y A P H T V
Sbjct: 645 DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQ 704
Query: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA 1492
T Q L+P Y FR+ A G P EA+ K P V
Sbjct: 705 TTAQLK---LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP-DKNPTAVEGLGSEP 760
Query: 1493 RSLRLQWVP--GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYK 1550
+L + W P G + P + + R+ + ++S + + +V F Y
Sbjct: 761 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD--EWTSVVVANVSKYIVSGTPTFVPYL 818
Query: 1551 LRLKATNDIGDSDFSSETEAVT--TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLN 1608
++++A ND+G F+ E V + +D+P PG+V ++ + W P +S+
Sbjct: 819 IKVQALNDMG---FAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIR 875
Query: 1609 GLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668
G LQGYRIYY + T++ + +N H E T S T M L L+
Sbjct: 876 GHLQGYRIYYWK--------TQSSSKRN--RRHIE----KKILTFQGSKTHGM--LPGLE 919
Query: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728
+ Y + + N GE PAS P VF AP ++++ T L + WD PP
Sbjct: 920 PFSHYTLNVRVVNGKGEGPAS-PDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPS 976
Query: 1729 SQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVR--LKNLTSHTKYLVSISAFNAAGD 1786
NG + Y + Y +S +E + L +P R LKNL T+Y A +AG
Sbjct: 977 HPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGS 1036
Query: 1787 GPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQ 1846
G + + T A P + ++ + +S AAA + Y + +
Sbjct: 1037 GSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAA----ETYANISWEYEGPE 1092
Query: 1847 GVSKVVTVEVRGNWQRWLKVRDLTKGVTYFF 1877
V+ V V G+ + W K ++ G FF
Sbjct: 1093 HVNFYVEYGVAGSKEEWRK--EIVNGSRSFF 1121
Score = 47.0 bits (110), Expect = 2e-04
Identities = 36/112 (32%), Positives = 47/112 (41%), Gaps = 7/112 (6%)
Query: 1895 TAGPAEGSPGSPRDVLVTKSASE-LTLQWTEGHSGDTPTTGYVIEARPS--DEGLWDMFV 1951
T P P P D+ +T + + L WT G ++P T ++IE + GLW
Sbjct: 639 TPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH--- 695
Query: 1952 KDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
S T T L KL V Y FRV+AVN G PS S + P
Sbjct: 696 HQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP 746
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 266 bits (681), Expect = 1e-70
Identities = 253/986 (25%), Positives = 408/986 (41%), Gaps = 65/986 (6%)
Query: 84 WALLALQLHLLRALAQDDV--APYFKTEPGLPQIHL--EGNRLVLTCLAEGSWPLEFKWM 139
W LL LQ +L LA D P F EP L E ++ L C +G+ +W
Sbjct: 5 WELLVLQSFIL-CLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWK 63
Query: 140 RDDSELTTYSSEYKYIIPSLQKL--------DAGFYRCVVRNRMGALLQRKSEVQVAYMG 191
+ +++ T +++Y + L DAG Y+C N G ++ R++++Q AY+
Sbjct: 64 LNGTDVDT-GMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLD 122
Query: 192 SFMDTDQRKTVS--QGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLEN-QLVI 248
+F T R TVS +G+ +L P W + NR ++ E L I
Sbjct: 123 NFK-TRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
Query: 249 LATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
SD G Y N P L I R+ G P I V A
Sbjct: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPL-ILRNDGVMGEYEPKIEVQFPETVPTAKG 240
Query: 309 SETTLECIASARPVEDLSVTWKR---NGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA 365
+ LEC A PV ++ W+R + + H L I N D G Y C A
Sbjct: 241 ATVKLECFALGNPVP--TIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
Query: 366 LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425
S + F +P + + + I +EE V C+A G P PT +W K+
Sbjct: 299 --NSRGKNVARGQLTFYAQPNWI--QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE 354
Query: 426 SISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQR 485
+ L R ++ G L I + D+G++QC A N+ G I ++ L V + P F++
Sbjct: 355 PL--LTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRT 411
Query: 486 PVD--TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPV 543
+ T V G ++ C+ +PKP TWK+ IL R + E G L+I V
Sbjct: 412 LLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE----RITISEDGNLRIINV 467
Query: 544 FIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRV 603
DAG+YTC A N G+ +++ L V + T ++ PP V G + L C THD +
Sbjct: 468 TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL 527
Query: 604 SLRYVWKKDNVAL----TPSSTSRI-VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSR 658
+ + W + + R+ + G L+I G Y C + + S
Sbjct: 528 DIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSA 587
Query: 659 MARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHL 718
A L V P P+ + + + + LSW D +SPI Y+++ +P+ V
Sbjct: 588 AADLIVRGPPGPPEAVTIDEITDTT--AQLSWRPGPDNHSPITMYVIQA---RTPFSVGW 642
Query: 719 SNVG--PEMTG-----VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAP 771
V PE+ TV GL P Y+FR A N +G G+ S + + E P
Sbjct: 643 QAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVT 702
Query: 772 PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCL 831
P N+ G + +++ W+ PE NG GY++ +R G ++ Y
Sbjct: 703 PANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVF 762
Query: 832 VTDLI-IWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW 890
+ + ++ +E++V +N G G FS Y+ + PT PP ++ ++++T I+ W
Sbjct: 763 RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW 822
Query: 891 NPPPQQFINGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSV 948
P ++ G QGY++ W + E A + T+ ITNLK Y +V
Sbjct: 823 ASPLEK-NRGRIQGYEVKYWRHEDKEENARKIRTVG----NQTSTKITNLKGSVLYHLAV 877
Query: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQ 1006
+ + G GP S V T++ P D+ + ++W + L+ + GY+
Sbjct: 878 KAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYK 937
Query: 1007 ISWEVYGRNDSRLTHTLNSTTHEYKI 1032
+ + + R S N T+ E +
Sbjct: 938 VLYR-WNRQSSTSVIETNKTSVELSL 962
Score = 165 bits (417), Expect = 5e-40
Identities = 192/748 (25%), Positives = 306/748 (40%), Gaps = 91/748 (12%)
Query: 384 EPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYK-DAISISRLQNPRYKVLASGG 442
EP PE+ +A+ TV + C A+G P+PT+ W + D I+R R+K ++G
Sbjct: 224 EPKIEVQFPETVPTAK-GATVKLECFALGNPVPTIIWRRADGKPIARKAR-RHK--SNGI 279
Query: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502
L I + ED+G+++C A N G+ L P + Q+ D V C+
Sbjct: 280 LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFY-AQPNWIQKINDIHVAMEENVFWECK 338
Query: 503 VSGAPKPAITWKRENHILASGSVRIPRFML-LESGGLQIAPVFIQDAGNYTCYAANTEGS 561
+G PKP W L +G + R + +E G L I V + DAG Y C A N G
Sbjct: 339 ANGRPKPTYKW------LKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 392
Query: 562 LNASATLTVWNRTSIVHPPEDHVVIKGTT-------ATLHCGATHDPRVSLRYVWKKDNV 614
+ ++A L+V V P ++K T + C P+ Y WKK
Sbjct: 393 IFSNAELSV----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV--YTWKKGRD 446
Query: 615 ALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNL 674
L RI + +DG+L I D G Y+C + G S L V + P +
Sbjct: 447 IL--KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD----PTRV 500
Query: 675 LVSPNS---------------SHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLS 719
+V P+S +H H++ + + F+G ++++ + H
Sbjct: 501 MVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG------HLIDFDRDGD----HFE 550
Query: 720 NVGPEMTGVTVSGLTPARTYQFR-----VCAVN-EVGRGQYSAETSRLMLPEEPPSAPPK 773
VG G +G R Q + VC V V R +A+ L P PP+
Sbjct: 551 RVG----GQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD-----LIVRGPPGPPE 601
Query: 774 NIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVN----- 828
+ T+ + + W+P P+ ++ + Y+++ R G Q T PE+
Sbjct: 602 AVTIDEITDTTAQLSWRPGPD--NHSPITMYVIQARTPFSVG--WQAVSTVPELIDGKTF 657
Query: 829 YCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTTIQ 887
V L W +YE + A N G+G SR + T + +P P NV + + +
Sbjct: 658 TATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELV 717
Query: 888 FLWNPPPQQFINGINQGYKLLAWP-ADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
W P++ NG GY + P +TV+ A V ++ F+ +
Sbjct: 718 ITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE--SVHPFSPFEV 775
Query: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKN-GIITG 1004
V F G+GP S +V++ E++P F L T ++V W PLEKN G I G
Sbjct: 776 KVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQG 835
Query: 1005 YQIS-WEVYGRNDS-RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTIS 1062
Y++ W + ++ R T+ + T KI L Y + V A + GTG +S+T++
Sbjct: 836 YEVKYWRHEDKEENARKIRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTG-PSSATVN 893
Query: 1063 SGVPPDLPGAPSNLVISNISPRSATLQF 1090
P P +I N S L +
Sbjct: 894 VTTRKPPPSQPPGNIIWNSSDSKIILNW 921
Score = 122 bits (305), Expect = 5e-27
Identities = 95/371 (25%), Positives = 157/371 (42%), Gaps = 29/371 (7%)
Query: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
R P PP + + E+T + +L W PG D SPI + +Q R WQ S+
Sbjct: 594 RGPPGPPEAVTID--EITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPEL 651
Query: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
I + V L P+ Y+ R A N IG + S +E T + +P P +VS
Sbjct: 652 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 711
Query: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
+ S ++I W+ +E NG GY + +R K L +A +S
Sbjct: 712 SKSELVITWETVPEELQNGRGFGYVVAFRPYG------------KMIWMLTVLASADASR 759
Query: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
+ S + + +EV + +N GE P S V+ E P P ++
Sbjct: 760 YVFRNES---------VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 810
Query: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
L+A+ +EV W P E G IQGY++ YW + + E + + ++ NL
Sbjct: 811 RSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKG 869
Query: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
Y +++ A+N+AG GP S T + P P + + + ++W + A +
Sbjct: 870 SVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDN 929
Query: 1830 -GILQGYRVVY 1839
++GY+V+Y
Sbjct: 930 ESEVKGYKVLY 940
Score = 114 bits (285), Expect = 1e-24
Identities = 104/434 (23%), Positives = 175/434 (40%), Gaps = 27/434 (6%)
Query: 1173 PDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDR 1232
P P +VT+ ++T+ +L W P PD+ + R + S V +++ +
Sbjct: 596 PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 655
Query: 1233 LEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSST 1291
T+ L W+EYE + A N +G G P + RT E++P P NVS S +
Sbjct: 656 TFTA-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 714
Query: 1292 QILLTWTSVPEQDQNGLILGYKILFRAKD--------LDPEPRSHIVRGNHTQSALLAGL 1343
++++TW +VPE+ QNG GY + FR L S V N + +
Sbjct: 715 ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNES-------V 767
Query: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEE 1403
F +E++V F G G S ++ +++ PP + + T + + W P E
Sbjct: 768 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827
Query: 1404 PN-GIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462
N G I GY++ Y + T+L Y + A G G
Sbjct: 828 KNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG- 886
Query: 1463 PLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRG 1522
P ATV T ++ P+ P ++ + + L V D S ++ + + R
Sbjct: 887 PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR----- 941
Query: 1523 EWQTYSSSISHEATACVVDRLRPF-TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581
W SS+ E V+ PF Y + +K +D GD SSE + + +
Sbjct: 942 -WNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGS-SSEQIRIPKISNAYARG 999
Query: 1582 PGSVSATPHTTSSV 1595
G+ ++ T S++
Sbjct: 1000 SGASTSNACTLSAI 1013
Score = 113 bits (283), Expect = 2e-24
Identities = 91/358 (25%), Positives = 161/358 (44%), Gaps = 24/358 (6%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTLYEEENEP 1128
PG P + I I+ +A L +RPG D + I+ ++++ + ++G + V+ E +
Sbjct: 597 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA--VSTVPELIDG 654
Query: 1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASET 1188
+ L P+ Y FR N++G S S +T +A P+V P +V+ S++
Sbjct: 655 KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 714
Query: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTIEE 1241
L + W +P+ NG GY + + W + +SA D F E
Sbjct: 715 ELVITWETVPEELQNG--RGFGYVVAFRPYGKMIWMLTVLASA------DASRYVFRNES 766
Query: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
+ + +E+++ FN G GP+S + E P+ P ++ A ++S+T I + W S P
Sbjct: 767 VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-P 825
Query: 1302 EQDQNGLILGYKILF-RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
+ G I GY++ + R +D + R GN T S + L+ VLY L V A+ G
Sbjct: 826 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAG 884
Query: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPE--EPNGIILGYQIAYR 1416
G PS+ + T+ P P + + + + W + + + GY++ YR
Sbjct: 885 TG-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR 941
Score = 102 bits (254), Expect = 4e-21
Identities = 112/463 (24%), Positives = 188/463 (40%), Gaps = 59/463 (12%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVEVGATVRQ 1436
PGPP + E+ T+ ++ W+P + + I Y I R S +TV +
Sbjct: 597 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 656
Query: 1437 FTAT--DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA-- 1492
FTAT L P Y FR A G GEP + ++R A P V A V+
Sbjct: 657 FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS---EKRRTEEALPE---VTPANVSGGG 710
Query: 1493 ---RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQ-TYSSSISHEATACVVDRLRPF 1546
L + W + R F V P G+ W T +S + + PF
Sbjct: 711 GSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPF 770
Query: 1547 TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDES 1606
+ +++++ N+ G+ FS T V + ++ P +PP S+ A + + + + W P +++
Sbjct: 771 SPFEVKVGVFNNKGEGPFSPTT-VVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN 829
Query: 1607 LNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTH 1666
G +QGY + Y E + + + +T+ N T ++T+
Sbjct: 830 -RGRIQGYEVKYWRHEDKEENARKIRTVGN----------------------QTSTKITN 866
Query: 1667 LKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPP 1726
LK Y + + AYN G P+SA V V + P+ P N+ + + S++ + WD
Sbjct: 867 LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVK 925
Query: 1727 PESQNGNIQGYKIYY-WEADSQN---ETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFN 1782
++GYK+ Y W S ET K V +L Y++ I F+
Sbjct: 926 ALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL---------SLPFDEDYIIEIKPFS 976
Query: 1783 AAGDGPKSD----PQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821
GDG S+ P+ + GA + A + +T+ +S
Sbjct: 977 DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMIS 1019
Score = 71.6 bits (174), Expect = 8e-12
Identities = 91/371 (24%), Positives = 146/371 (39%), Gaps = 67/371 (18%)
Query: 1578 PGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNP 1637
P PP +V+ T ++ + W+P D +P
Sbjct: 596 PPGPPEAVTIDEITDTTAQLSWRPGPDN-----------------------------HSP 626
Query: 1638 IALHAELTAQSSFKTVNSSSTSTMCEL----------THLKKYRRYEVIMTAYNIIGESP 1687
I ++ + A++ F +V + ST+ EL L + YE A N+IG
Sbjct: 627 ITMYV-IQARTPF-SVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 684
Query: 1688 ASAPVEV-FVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY----- 1741
S P E EA P + P NV + S+L +TW+ P E QNG GY + +
Sbjct: 685 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 744
Query: 1742 --WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQ 1799
W + + +F R +++ + + V + FN G+GP S + +
Sbjct: 745 MIWMLTVLASADASRYVF------RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 798
Query: 1800 AAPGAPSFLAFS-EITSTTLNVSWGEPAAAN-GILQGYRVVY-EPLAPVQGVSKVVTVEV 1856
P P F+ +++T + V W P N G +QGY V Y + K+ TV
Sbjct: 799 EEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV-- 856
Query: 1857 RGNWQRWLKVRDLTKGVTYFFRVQA-RTITYGP-ELQANITA-GPAEGSPGSPRDVLVTK 1913
GN Q K+ +L V Y V+A + GP N+T P P P +++
Sbjct: 857 -GN-QTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQP--PGNIIWNS 912
Query: 1914 SASELTLQWTE 1924
S S++ L W +
Sbjct: 913 SDSKIILNWDQ 923
Score = 54.7 bits (130), Expect = 1e-06
Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 4/96 (4%)
Query: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPR--S 1957
G PG P V + + + + L W G +P T YVI+AR W V +P
Sbjct: 595 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 653
Query: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993
++T ++ L V YEFR VA N G GEPS PS
Sbjct: 654 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS 689
Score = 42.7 bits (99), Expect = 0.004
Identities = 57/215 (26%), Positives = 77/215 (35%), Gaps = 23/215 (10%)
Query: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTV-EVRGNW 1860
PG P + EIT TT +SW P N V+ G V TV E+
Sbjct: 597 PGPPEAVTIDEITDTTAQLSW-RPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 655
Query: 1861 QRWLKVRDLTKGVTYFFR-VQARTITYG-----------PELQANITAGPAEGSPGSPRD 1908
V L V Y FR V A I G E +T G GS +
Sbjct: 656 TFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 715
Query: 1909 VLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKL 1968
+++T LQ G GYV+ RP + +W M A+ Y + +
Sbjct: 716 LVITWETVPEELQNGRGF-------GYVVAFRPYGKMIW-MLTVLASADASRYVFRNESV 767
Query: 1969 RQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
+E +V N G G P +P+T V + E P
Sbjct: 768 HPFSPFEVKVGVFNNKGEG-PFSPTTVVYSAEEEP 801
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 265 bits (678), Expect = 3e-70
Identities = 276/1014 (27%), Positives = 422/1014 (41%), Gaps = 113/1014 (11%)
Query: 327 VTWKRNGVRITSGLHSFGRRLTISNPT------------SADTGPYVCEAALPGSAFEPA 374
+ WK++G+ + G+ R+ +SN + D G Y CEA+L S +
Sbjct: 72 IKWKKDGIHLALGMDE--RKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIIS 129
Query: 375 RATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQ-NP 433
R TA + + P F ++ ES ++A + +TV + C+ +G P+PT+ W K+ ++ + +
Sbjct: 130 R-TAKVAVAGPLRFLSQTES-VTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDS 187
Query: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNE-----GGEIQTHTYLDV-TNIAPVFTQRPV 487
R VL SG L+I +L+P D GI++C A N G E + D + F QRP
Sbjct: 188 RVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPS 247
Query: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
+ +G A+L C VSG P P+ TW R ++ +R ++ LL L I+ V D
Sbjct: 248 NVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI---QLRSKKYSLLGGSNLLISNVTDDD 304
Query: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRY 607
+G YTC +++ASA LTV ++ P + + C + P ++
Sbjct: 305 SGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVN- 363
Query: 608 VWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE- 666
W K+ + PS +IV +L I D G Y C +E GN A+L V +
Sbjct: 364 -WMKNGDVVIPSDYFQIV--GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
Query: 667 -------LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLS 719
LP +P++++ P S V LSW P + I + V S + L+
Sbjct: 421 AIPSSSVLPSAPRDVV--PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN 478
Query: 720 NVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779
P +TV L P Y FRV A NE G G+ S PE P +N+ A
Sbjct: 479 TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVS 538
Query: 780 RTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWT 839
+ SI++ W+PP NG ++GY L +++NI ++Y L L +T
Sbjct: 539 TSPTSILITWEPPAYA--NGPVQGYRL---FCTEVSTGKEQNIEVDGLSYKL-EGLKKFT 592
Query: 840 QYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFIN 899
+Y ++ AYN G GV + +T TL VP+APPQNV E VNS +I+ W PPP N
Sbjct: 593 EYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQN 652
Query: 900 GINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPP 959
G GYK+ + T+ P+ T L+K + Y V T G GPP
Sbjct: 653 GFITGYKIR--HRKTTRRGEMETLEPNNLWY---LFTGLEKGSQYSFQVSAMTVNGTGPP 707
Query: 960 S------TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG 1013
S TP+ + P L + + +SW PL N ++ GY I + V
Sbjct: 708 SNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-MSWTPPLNPNIVVRGYIIGYGV-- 764
Query: 1014 RNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG--LVTSSTISSGVPP---- 1067
+ T ++S Y I+ L S + Y I + A G G L S+T S P
Sbjct: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPV 824
Query: 1068 -------DLPGAPSNLVISNISP-------------RSATLQFRPGYDGKTS-----ISR 1102
D P + +L + P R + + KTS R
Sbjct: 825 DYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
Query: 1103 WIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPS 1162
W A E+ +L L P T Y F + S +S +
Sbjct: 885 WRTSFSASAKYKSEDTTSL----------SYTATGLKPNTMYEFSVMVTKNRRSSTWSMT 934
Query: 1163 SRVIQTLQAPPDVAPTSVTV--RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYW---R 1217
+ T +A P AP +TV R ++ + W P N + Y + Y
Sbjct: 935 AHA-TTYEAAPTSAPKDLTVITREGKPRAVIVSWQP----PLEANGKITAYILFYTLDKN 989
Query: 1218 SDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRT 1271
+ + + DRL + I +L Y ++QA N+ G GP S+ + RT
Sbjct: 990 IPIDDWIMETISGDRLTHQ--IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
Score = 192 bits (487), Expect = 4e-48
Identities = 263/1098 (23%), Positives = 434/1098 (39%), Gaps = 146/1098 (13%)
Query: 358 GPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPT 417
G + A L + F+ TA F+ EP + + D G +P
Sbjct: 19 GASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRG-------VPV 71
Query: 418 LQWYKDAISISRLQNPRYKVLASGGLRIQKL-----RPEDSGIFQCFAS-NEGGEIQTHT 471
++W KD I ++ + R + L++G L IQ + D G++QC AS + G I + T
Sbjct: 72 IKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRT 131
Query: 472 YLDVTNIAPV-FTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP-- 528
V P+ F + T G T +L+CEV G P P I W++ L IP
Sbjct: 132 -AKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTP----IPGD 186
Query: 529 -RFMLLESGGLQIAPVFIQDAGNYTCYAAN-------TEGSLNASATLTVWNRTSIVHPP 580
R ++L SG LQI+ + D G Y C A N E + + + + + P
Sbjct: 187 SRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRP 246
Query: 581 EDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG 640
+ V I+G A L C + P S ++ ++ + L S + +LLIS
Sbjct: 247 SNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLL---GGSNLLISNVTDD 303
Query: 641 DIGDYSCEIVSEGGNDSRMARLEVIELP---HSPQNLLVSPNS--------SHSHAVVLS 689
D G Y+C + + N S A L V+ P + P NL + S ++
Sbjct: 304 DSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVN 363
Query: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749
W++ D P Y+ + N + + G+ + ++ A NE
Sbjct: 364 WMKNGDVVIPSDYFQIVGGSN-----------------LRILGVVKSDEGFYQCVAENEA 406
Query: 750 GRGQYSAETSRLMLPEEP-------PSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802
G Q SA+ L++P+ PSA P+++V +++ + + W+PP E + N ++
Sbjct: 407 GNAQTSAQ---LIVPKPAIPSSSVLPSA-PRDVVPVLVSSRFVRLSWRPPAEAKGN--IQ 460
Query: 803 GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAV-- 860
+ + + G + N T P V +L Y +V AYN G G S+ +
Sbjct: 461 TFTVFFSREG-DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKV 519
Query: 861 -TEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVT 919
T+ LQ VP P +N+Q + + T+I W PP + NG QGY+L +
Sbjct: 520 ATQPELQ-VP-GPVENLQAVSTSPTSILITWEPP--AYANGPVQGYRLFCTEVSTGKEQN 575
Query: 920 VVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLS 979
+ + G+ + + LKKFT Y L + G G + V T D P A
Sbjct: 576 I-----EVDGLSY-KLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
Query: 980 FTEILDT-SLKVSWQEPLE--KNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLS 1036
E++++ S+KVSW P +NG ITGY+I R TL Y GL
Sbjct: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE--METLEPNNLWYLFTGLE 687
Query: 1037 SLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDL-----PGAPSNLVISNISPRS--ATLQ 1089
+ Y+ V+A+T GTG ++ + DL P PS+L ++ P++ +
Sbjct: 688 KGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSL---HVRPQTNCIIMS 744
Query: 1090 FRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQM--LEIPNLTPYTHYRFR 1147
+ P + + +I+ VG + Y E D++ I L +HY
Sbjct: 745 WTPPLNPNIVVRGYIIGYGVG---------SPYAETVRVDSKQRYYSIERLESSSHYVIS 795
Query: 1148 MKQVNIVG---PSPYSPSSRVIQTLQAP-------------------PDVAPTSVTVRTA 1185
+K N G P S ++R I P P + P V
Sbjct: 796 LKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL 855
Query: 1186 SETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEW 1245
+ ++R+ W + E Y ++ WR+ +SA + D +T L+
Sbjct: 856 THDAVRVSWADNSVPKNQKTSEVRLYTVR-WRTSFSASAKYK-SEDTTSLSYTATGLKPN 913
Query: 1246 MEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPEN--VSAEAVSSTQILLTWTSVPEQ 1303
YE + + WS T E+ P++AP++ V ++++W P
Sbjct: 914 TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ--PPL 971
Query: 1304 DQNGLILGYKILFRAKDLDPEPRSHI---VRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
+ NG I Y ILF D + I + G+ ++ L +Y ++ A G
Sbjct: 972 EANGKITAY-ILFYTLDKNIPIDDWIMETISGDRLTHQIM-DLNLDTMYYFRIQARNSKG 1029
Query: 1361 NGVPSTPLILERTKDDAP 1378
G S P++ K + P
Sbjct: 1030 VGPLSDPILFRTLKVEHP 1047
Score = 156 bits (394), Expect = 2e-37
Identities = 180/668 (26%), Positives = 279/668 (41%), Gaps = 84/668 (12%)
Query: 990 VSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVT 1049
V+W KNG + +++ G ++ R+ + S Y Q ++ +A
Sbjct: 362 VNWM----KNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFY--QCVAENEAGNAQTSAQL 415
Query: 1050 AVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQV 1109
V + SS++ LP AP ++V +S R L +RP + K +I + V
Sbjct: 416 IVPKPAIPSSSV-------LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF--F 466
Query: 1110 GAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQT- 1168
GD E +P + L + NL P Y FR+ N GP S +V
Sbjct: 467 SREGDNRERAL---NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQP 523
Query: 1169 -LQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQ 1227
LQ P V ++ + S TS+ + W P Y P GYR+ + +++ +
Sbjct: 524 ELQVPGPVE--NLQAVSTSPTSILITWEP---PAYANGPVQ-GYRL--FCTEVSTGKEQN 575
Query: 1228 VVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEA 1287
+ D L + +E L+++ EY L+ A+N G G ++ + T VPSA P+NVS E
Sbjct: 576 IEVDGLS--YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV 633
Query: 1288 VSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFV 1347
V+S I ++W P QNG I GYKI R E + + N+ L GL K
Sbjct: 634 VNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET--LEPNNLW-YLFTGLEKGS 690
Query: 1348 LYELQVLAFTRIGNGVPSTPLILERTKDD-----APGPPVRL-VFPEVRLTSVRIVWQPP 1401
Y QV A T G G PS E ++D P P L V P+ + + W PP
Sbjct: 691 QYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT--NCIIMSWTPP 748
Query: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
PN ++ GY I Y + SP+ TV V + R ++ L S Y+ L A G G
Sbjct: 749 LNPNIVVRGYIIGYGV--GSPYA-ETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEG 805
Query: 1462 EPLEATVITTEKRERPAPPREL-----------------LVPQAEVTARSL-----RLQW 1499
PL + TT P P + ++P V A +L R+ W
Sbjct: 806 VPLYESA-TTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW 864
Query: 1500 ----VPGSDGASPIRYFTMQVRELPRGEWQTYS---SSISHEATACVVDRLRPFTSYKLR 1552
VP + S +R +T++ R + S +S+S+ AT L+P T Y+
Sbjct: 865 ADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATG-----LKPNTMYEFS 919
Query: 1553 LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH--TTSSVLIQWQPPRDESLNGL 1610
+ T + S +S A TT + P P ++ +V++ WQPP + NG
Sbjct: 920 VMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE--ANGK 976
Query: 1611 LQGYRIYY 1618
+ Y ++Y
Sbjct: 977 ITAYILFY 984
Score = 135 bits (339), Expect = 6e-31
Identities = 241/1071 (22%), Positives = 392/1071 (36%), Gaps = 140/1071 (13%)
Query: 482 FTQRPVDTTVTDGMTAILRCEV-SGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI 540
F P D G +L C S P I WK++ LA G R L +G L I
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDE--RKQQLSNGSLLI 99
Query: 541 APVFIQ-----DAGNYTCYAA--NTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATL 593
+ D G Y C A+ ++ ++ +A + V + E G T L
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 594 HCGATHDPRVSLRYVWKKDNVALTP-SSTSRIVVEKDGSLLISQTWSGDIGDYSCEI--- 649
C +P ++ W+K+ LTP SR+VV G+L IS+ GDIG Y C
Sbjct: 160 KCEVIGEPMPTIH--WQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNP 217
Query: 650 -VSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS 708
S GN+ A + ++ P + L S+ A+ +G +L E
Sbjct: 218 ASSRTGNE---AEVRILSDPGLHRQLYFLQRPSNVVAI--------EGKDAVL----ECC 262
Query: 709 ENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
+ P G E+ + + + V + G Y+ +
Sbjct: 263 VSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTY-------- 314
Query: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVN 828
KN S +++V PP H L Y + E P VN
Sbjct: 315 ----KNENISASAELTVLV---PPWFLNHPSNLYAY----ESMDIEFECTVSGKPVPTVN 363
Query: 829 YCLVTDLIIWTQYEIQVAAYNGAGLGV------FSRAVTEYTLQGVPTAPPQNVQTEAVN 882
+ D++I + Y V N LGV F + V E T+ V A+
Sbjct: 364 WMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
Query: 883 STTIQFLWNPPPQQFINGINQGYKLLAW--PADAPEAVTVVTIAPDFHGVHHGH------ 934
S+++ L + P ++ + L+W PA+A + T+ G +
Sbjct: 424 SSSV--LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQ 481
Query: 935 -------ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDK--PGAVGHLSFTEILD 985
+ NLK Y V+ + G G S P V TQ + PG V +L
Sbjct: 482 PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSP 541
Query: 986 TSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDV 1045
TS+ ++W+ P NG + GY++ + + YK++GL T Y++
Sbjct: 542 TSILITWEPPAYANGPVQGYRLFCTEVSTGKEQ---NIEVDGLSYKLEGLKKFTEYSLRF 598
Query: 1046 AAVTAVGTGLVTSSTISSGVPPDLPGAP-SNLVISNISPRSATLQFRPGYDGKTS--ISR 1102
A G G V++ I+ D+P AP N+ + ++ RS + + P G + I+
Sbjct: 599 LAYNRYGPG-VSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITG 657
Query: 1103 WIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS-- 1160
+ + + E E + EP+ L + Y F++ + + G P S
Sbjct: 658 YKIRHRKTTRRGEMETL-------EPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNW 710
Query: 1161 -----PSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKY 1215
P + + ++ Q P P+S+ VR + + + W P N N GY I Y
Sbjct: 711 YTAETPENDLDES-QVPDQ--PSSLHVRPQTNCII-MSWTP----PLNPNIVVRGYIIGY 762
Query: 1216 WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRE- 1273
+ S V D +R ++IE LE Y + ++AFN G G P E R+
Sbjct: 763 ---GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITD 819
Query: 1274 ---------------------SVPSAAPENVSAEAVSSTQILLTWT--SVPEQDQNGLIL 1310
S P P V A A++ + ++W SVP+ + +
Sbjct: 820 PTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVR 879
Query: 1311 GYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPL-- 1368
Y + +R + + S GL+ +YE V+ + S
Sbjct: 880 LYTVRWRTSF--SASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA 937
Query: 1369 -ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTT 1427
E AP + ++ E + +V + WQPP E NG I Y + Y L + P
Sbjct: 938 TTYEAAPTSAP-KDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWI 996
Query: 1428 VE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERP 1477
+E + DL ++ Y FR+ A+ +G G + + T K E P
Sbjct: 997 METISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHP 1047
Score = 130 bits (328), Expect = 1e-29
Identities = 169/681 (24%), Positives = 265/681 (38%), Gaps = 90/681 (13%)
Query: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYR 1212
++ P P PSS V+ + AP DV P V+ R +RL W P +++ N +V +
Sbjct: 415 LIVPKPAIPSSSVLPS--APRDVVPVLVSSRF-----VRLSWRPPAEAKGNIQTFTVFFS 467
Query: 1213 IKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTR 1272
+ D + A+ L+ T+ L+ Y ++ A+N G G S+ ++ T+
Sbjct: 468 RE---GDNRERALNTTQPGSLQ--LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ 522
Query: 1273 ESVPSAAP-ENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR 1331
+ P EN+ A + S T IL+TW P NG + GY++ E +
Sbjct: 523 PELQVPGPVENLQAVSTSPTSILITWE--PPAYANGPVQGYRLFCTEVSTGKEQNIEV-- 578
Query: 1332 GNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRL 1391
S L GL+KF Y L+ LA+ R G GV + + + D PP + V
Sbjct: 579 --DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNS 636
Query: 1392 TSVRIVWQPPEE--PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYI 1449
S+++ W PP NG I GY+I +R + T+E FT L S Y
Sbjct: 637 RSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE-METLEPNNLWYLFTG--LEKGSQYS 693
Query: 1450 FRLSAKTRQGWGEPLEATVITT-----EKRERPAPPRELLV-PQAEVTARSLRLQWVPGS 1503
F++SA T G G P T ++ + P P L V PQ S W P
Sbjct: 694 FQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMS----WTPPL 749
Query: 1504 DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACV--VDRLRPFTSYKLRLKATNDIGD 1561
+ +R + + G Y+ ++ ++ ++RL + Y + LKA N+ G+
Sbjct: 750 NPNIVVRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGE 804
Query: 1562 SD---FSSETEAVTTLQD-------------------VPGEPPGSVSATPHTTSSVLIQW 1599
S+ T ++T D P PP V A T +V + W
Sbjct: 805 GVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW 864
Query: 1600 QPPRDESL--NGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSS 1657
D S+ N R+Y + +A + +K+ +++S
Sbjct: 865 A---DNSVPKNQKTSEVRLY-------------------TVRWRTSFSASAKYKSEDTTS 902
Query: 1658 TSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQ 1717
S T LK YE + S S EAAP AP+++ V
Sbjct: 903 LSYTA--TGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
Query: 1718 LEVTWDPPPPESQNGNIQGYKIYY-WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLV 1776
V PP NG I Y ++Y + + + M+ + ++ +L T Y
Sbjct: 961 RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
Query: 1777 SISAFNAAGDGPKSDPQQGRT 1797
I A N+ G GP SDP RT
Sbjct: 1021 RIQARNSKGVGPLSDPILFRT 1041
Score = 115 bits (288), Expect = 5e-25
Identities = 106/421 (25%), Positives = 179/421 (42%), Gaps = 56/421 (13%)
Query: 1476 RPAPPRELLVPQAE-------VTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528
+PA P ++P A V++R +RL W P ++ I+ FT+ + +
Sbjct: 419 KPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN 478
Query: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQ-DVPGEPPGSVSA 1587
++ + V L+P Y R+ A N+ G + S + T + VPG P ++ A
Sbjct: 479 TT-QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPG-PVENLQA 536
Query: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
+ +S+LI W+PP NG +QGYR++ E+
Sbjct: 537 VSTSPTSILITWEPPA--YANGPVQGYRLFCTEV-------------------------- 568
Query: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
S+ K N +L LKK+ Y + AYN G ++ + V P+ PQN
Sbjct: 569 STGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQN 628
Query: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRL-K 1766
V + + + ++V+W PPP +QNG I GYKI + + + E E ++ P + L
Sbjct: 629 VSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE----PNNLWYLFT 684
Query: 1767 NLTSHTKYLVSISAFNAAGDGPKSD------PQQGRTHQAAPGAPSFLAFSEITSTTLNV 1820
L ++Y +SA G GP S+ P+ P PS L T+ + +
Sbjct: 685 GLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-M 743
Query: 1821 SWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQ 1880
SW P N +++GY + Y +P ++ V V+ + QR+ + L Y ++
Sbjct: 744 SWTPPLNPNIVVRGYIIGYGVGSP---YAETVRVDSK---QRYYSIERLESSSHYVISLK 797
Query: 1881 A 1881
A
Sbjct: 798 A 798
Score = 102 bits (254), Expect = 4e-21
Identities = 146/648 (22%), Positives = 244/648 (37%), Gaps = 87/648 (13%)
Query: 1274 SVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGN 1333
SV +AP +V VSS + L+W P + G I + + F +++ D R+
Sbjct: 426 SVLPSAPRDVVPVLVSSRFVRLSWR--PPAEAKGNIQTFTVFF-SREGDNRERALNTTQP 482
Query: 1334 HTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPL-ILERTKDDAPGPPVRLVFPEVRLT 1392
+ + L+ +Y +V+A+ G G S P+ + + + PGP L T
Sbjct: 483 GSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPT 542
Query: 1393 SVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRL 1452
S+ I W+PP NG + GY++ S+ +EV + L + Y R
Sbjct: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKEQ--NIEVDGL--SYKLEGLKKFTEYSLRF 598
Query: 1453 SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVP---GSDGASPI 1509
A R G G + + T APP+ V V +RS+++ W+P G+
Sbjct: 599 LAYNRYGPGVSTDDITVVTLSDVPSAPPQN--VSLEVVNSRSIKVSWLPPPSGTQNGFIT 656
Query: 1510 RYFTMQVRELPRGEWQTYS--------------SSISHEATACVVDRLRPFTSYKLRLKA 1555
Y + RGE +T S S + +A V+ P +++
Sbjct: 657 GYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716
Query: 1556 TNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESL--NGLLQG 1613
ND+ +S VP +P S+ P T + +++ W PP + ++ G + G
Sbjct: 717 ENDLDESQ-------------VPDQP-SSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIG 761
Query: 1614 YRI---------------YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658
Y + YY E+ S I+L A A S++T
Sbjct: 762 YGVGSPYAETVRVDSKQRYYSIERLESSS-------HYVISLKAFNNAGEGVPLYESATT 814
Query: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718
++ + T Y Y ++ + P S P + P + P VQ LT +
Sbjct: 815 RSITDPTDPVDY---------YPLLDDFPTSVP-----DLSTPMLPPVGVQAVALTHDAV 860
Query: 1719 EVTW-DPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVS 1777
V+W D P++Q + W S + + K K L +T Y S
Sbjct: 861 RVSWADNSVPKNQKTSEVRLYTVRWRT-SFSASAKYKSEDTTSLSYTATGLKPNTMYEFS 919
Query: 1778 ISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAF--SEITSTTLNVSWGEPAAANGILQG 1834
+ S T++AAP AP L E + VSW P ANG +
Sbjct: 920 VMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITA 979
Query: 1835 YRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQAR 1882
Y +++ L + + + G+ + ++ DL Y+FR+QAR
Sbjct: 980 Y-ILFYTLDKNIPIDDWIMETISGD-RLTHQIMDLNLDTMYYFRIQAR 1025
Score = 67.8 bits (164), Expect = 1e-10
Identities = 85/342 (24%), Positives = 131/342 (38%), Gaps = 55/342 (16%)
Query: 1679 AYNIIGESPASA----PVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNI 1734
A N G + SA P + AP++V +++ + ++W PP GNI
Sbjct: 402 AENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA--EAKGNI 459
Query: 1735 QGYKIYYWEADSQNETEKMKVLFLPEP---VVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
Q + +++ S+ + + L +P + + NL Y + A+N G G S
Sbjct: 460 QTFTVFF----SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQ 515
Query: 1792 PQQGRTHQA--APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVS 1849
P + T PG L + T++ ++W PA ANG +QGYR+ ++
Sbjct: 516 PIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVS----TG 571
Query: 1850 KVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQAN----ITAGPAEGSPGS 1905
K +EV G K+ L K Y R A YGP + + +T +P
Sbjct: 572 KEQNIEVDG---LSYKLEGLKKFTEYSLRFLAYN-RYGPGVSTDDITVVTLSDVPSAPPQ 627
Query: 1906 PRDVLVTKSASELTLQWTEGHSGDTP--TTGYVIEARPSDE----------GLWDMFVKD 1953
+ V S S + + W SG TGY I R + LW +F
Sbjct: 628 NVSLEVVNSRS-IKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTG- 685
Query: 1954 IPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTA 1995
L +G Y F+V A+ G G PSN TA
Sbjct: 686 --------------LEKGSQYSFQVSAMTVNGTGPPSNWYTA 713
Score = 58.9 bits (141), Expect = 5e-08
Identities = 69/270 (25%), Positives = 97/270 (35%), Gaps = 23/270 (8%)
Query: 40 LAPRPGPE-----PSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLL 94
L P PG PS GD G RC R A G +L+ L
Sbjct: 180 LTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPASSRTGNEAEVRILS-DPGLH 237
Query: 95 RALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKY 154
R L YF P + +EG VL C G P F W+R + + S +Y
Sbjct: 238 RQL-------YFLQRPS-NVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSL 289
Query: 155 I------IPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAA 208
+ I ++ D+G Y CVV + + +E+ V F++ +
Sbjct: 290 LGGSNLLISNVTDDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDI 348
Query: 209 ILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKN 268
++ P P V W + G +IPS+ I + L IL SD G Y A NE
Sbjct: 349 EFECT-VSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAG 407
Query: 269 GENKTSPFIHLSIARDVGTPETMAPTIVVP 298
++ I A + AP VVP
Sbjct: 408 NAQTSAQLIVPKPAIPSSSVLPSAPRDVVP 437
Score = 32.3 bits (72), Expect = 5.3
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Query: 1960 SYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNP-STAVSAQVEAP 2003
S L++ L+ Y FRVVA NE G GE S P A +++ P
Sbjct: 484 SLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP 528
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 265 bits (676), Expect = 5e-70
Identities = 242/938 (25%), Positives = 389/938 (41%), Gaps = 55/938 (5%)
Query: 165 GFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQ-GRAAILNLLPITSYPRPQV 223
G Y+C RN+ G L + +QV+ + + V Q G L P P P +
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVI 167
Query: 224 TWFREGHKIIPSNRIAITLEN-----QLVILATTTSD----AGAYYVQAVNEKNG----- 269
W + I ++ N V+L +D A ++ + +KN
Sbjct: 168 FWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
Query: 270 -----ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPV 322
N +S H + G E P+ + P G S +V + LECIAS P
Sbjct: 228 LTNHPYNDSSLRNHPDMYSARGVAER-TPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 286
Query: 323 EDLSVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
D++ W + G + S +F + L I+N + D+G Y C L + R T
Sbjct: 287 PDIA--WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC---LASNKMGSIRHTIS 341
Query: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI-SRLQNPRYKVL 438
+ + PY+ EP++ I A E+ + C+A G P PT+QW + + S NP +V
Sbjct: 342 VRVKAAPYWLDEPKNLILAPGEDG-RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV- 399
Query: 439 ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTA 497
A + + + ++QC SNE G + + ++ V ++ P + + R V
Sbjct: 400 AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 459
Query: 498 ILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
L C G+P P + W + ++ + + E+G L+I + +D G YTC A N
Sbjct: 460 RLDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
Query: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALT 617
G L V + T I PED V +GTT L C HDP + L W KD+
Sbjct: 517 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD---E 573
Query: 618 PSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
P + ++D SL I D G Y+C +E D A L V+ P P++L ++
Sbjct: 574 PLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELT 633
Query: 678 PNSSHSHAVVLSWVRPFDGNSPILYYIVELSENN-SPWKVHLSNVGPEMTGVTVSGLTPA 736
+ S V L+W+ NSPI Y+V+ E+ P H + P V L+P
Sbjct: 634 DLAERS--VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPY 691
Query: 737 RTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETE 796
YQFRV A+NEVG S + R PP + P ++ G ++ + W P T
Sbjct: 692 VNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATS 751
Query: 797 HNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF 856
G YI+++R + N+T Y +V ++ YEI+V A N G G
Sbjct: 752 AFGPNLRYIVKWRRRETREAW--NNVTVWGSRY-VVGQTPVYVPYEIRVQAENDFGKGPE 808
Query: 857 SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPE 916
+V Y+ + P A P V+ +NST I WN + G + Y+ W +
Sbjct: 809 PESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLL 868
Query: 917 A---VTVVTIAPDFHGVH-HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKP 972
V+ F G G ++ L ++ Y ++ GDGP S + T E P
Sbjct: 869 KNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVP 928
Query: 973 GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG--RNDSRLTHTLNSTTHEY 1030
A + ++ + W P NGI+ GY + + + + ++ + ++
Sbjct: 929 SAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKF 988
Query: 1031 KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPD 1068
+Q ++ Y ++A T VG+G + T S PP+
Sbjct: 989 TVQRTDPVSRYRFTLSARTQVGSG--EAVTEESPAPPN 1024
Score = 130 bits (326), Expect = 2e-29
Identities = 107/420 (25%), Positives = 185/420 (44%), Gaps = 25/420 (5%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
P P +L +++++ RS L + PG + I+ ++V+ + D+ + ++ P
Sbjct: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEE----DQFQPGVWHDHSKYPG 679
Query: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
+ + L+PY +Y+FR+ +N VG S S S +T APP+ P V + +
Sbjct: 680 SVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNN 739
Query: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249
+ + W P+ + G ++ Y +K+ R + + + V + + + ++ YE
Sbjct: 740 MEITWTPMNATSAFG--PNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPVYVPYE 794
Query: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
+++QA N G GP E V G + E P AAP V ++ST I L W V G +
Sbjct: 795 IRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQL 854
Query: 1310 LGYKILF-RAKDL-----DPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGV 1363
Y+ + R L + R +++ L + Y+L+++ G+G
Sbjct: 855 REYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG- 913
Query: 1364 PSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPH 1423
P + T + P P R + L ++ + W PE PNGI++GY + Y + +
Sbjct: 914 PRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKV 973
Query: 1424 TFTTVE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
VE +FT P S Y F LSA+T+ G GE + E PAPP E
Sbjct: 974 GKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAV--------TEESPAPPNE 1025
Score = 126 bits (317), Expect = 2e-28
Identities = 112/437 (25%), Positives = 177/437 (40%), Gaps = 40/437 (9%)
Query: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRE--LPRGEWQTYSSSISH 1533
RP PR+L + ++ RS+RL W+PG SPI + +Q E G W +S
Sbjct: 623 RPDRPRDLEL--TDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGS 680
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+A + RL P+ +Y+ R+ A N++G S S +E T P PG V +
Sbjct: 681 VNSAVL--RLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKN 738
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
++ I W P S G Y + +R E +T S V
Sbjct: 739 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNN--------------VTVWGSRYVV 784
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ Y YE+ + A N G+ P V + GE P AP V+V +
Sbjct: 785 GQTPV-----------YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM 833
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVRLKNLTS- 1770
++ + + W+ ++ G ++ Y+ YYW S +N K P RL+ + S
Sbjct: 834 NSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSR 893
Query: 1771 ---HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
++ Y + + N GDGP+S+ ++ T + P AP + T+N+ W P
Sbjct: 894 LFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEH 953
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITY 1886
NGI+ GY + Y + V K + N Q V+ Y F + ART +
Sbjct: 954 PNGIMIGYTLKYVAFNGTK-VGKQIVENFSPN-QTKFTVQRTDPVSRYRFTLSARTQVGS 1011
Query: 1887 GPELQANITAGPAEGSP 1903
G + A P E +P
Sbjct: 1012 GEAVTEESPAPPNEATP 1028
Score = 74.7 bits (182), Expect = 9e-13
Identities = 96/423 (22%), Positives = 164/423 (38%), Gaps = 47/423 (11%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-----HTFTTVEVGA 1432
P P L ++ SVR+ W P + N I Y + + P H+ V +
Sbjct: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS 683
Query: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL--VPQAEV 1490
V + L+P Y FR+ A G P ++ + R APP V
Sbjct: 684 AVLR-----LSPYVNYQFRVIAINEVGSSHP---SLPSERYRTSGAPPESNPGDVKGEGT 735
Query: 1491 TARSLRLQWVP--GSDGASP-IRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFT 1547
++ + W P + P +RY R R W ++++ + VV + +
Sbjct: 736 RKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW----NNVTVWGSRYVVGQTPVYV 791
Query: 1548 SYKLRLKATNDIGDSDFSSETEAVTTL--QDVPGEPPGSVSATPHTTSSVLIQWQPPRDE 1605
Y++R++A ND G E E+V +D P P V ++++ +QW +
Sbjct: 792 PYEIRVQAENDFGKGP---EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD 848
Query: 1606 SLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELT 1665
++ G L+ YR YY E+ LKN ++ Q+SF ++
Sbjct: 849 TVQGQLREYRAYY---------WRESSLLKN--LWVSQKRQQASFPGDRLRGV-----VS 892
Query: 1666 HLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPP 1725
L Y Y++ M N G+ P S E E P+ AP+ +V + + WD
Sbjct: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWD-- 949
Query: 1726 PPESQNGNIQGYKIYYWEADSQNETEKMKVLFLP-EPVVRLKNLTSHTKYLVSISAFNAA 1784
PE NG + GY + Y + +++ F P + ++ ++Y ++SA
Sbjct: 950 HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQV 1009
Query: 1785 GDG 1787
G G
Sbjct: 1010 GSG 1012
Score = 60.8 bits (146), Expect = 1e-08
Identities = 103/484 (21%), Positives = 182/484 (37%), Gaps = 52/484 (10%)
Query: 1577 VPGEP--PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTL 1634
V G P P + T SV + W P ++ N + Y + + E +++ G +
Sbjct: 620 VLGRPDRPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEEDQFQPGVWHD---- 673
Query: 1635 KNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEV 1694
H++ +VNS+ + L Y Y+ + A N +G S S P E
Sbjct: 674 ------HSKYPG-----SVNSA-------VLRLSPYVNYQFRVIAINEVGSSHPSLPSER 715
Query: 1695 FVGEAAPAMA-PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKM 1753
+ AP + P +V+ + +E+TW P S G Y I W E
Sbjct: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY-IVKWRRRETREAWNN 774
Query: 1754 KVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSE 1812
++ VV + + Y + + A N G GP+ + G + + P AP+ +
Sbjct: 775 VTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRV 832
Query: 1813 ITSTTLNVSWGEPAA--ANGILQGYRVVY----EPLAPVQGVSKVVTVEVRGNWQRWLKV 1866
+ ST +++ W + G L+ YR Y L + K G+ R +
Sbjct: 833 MNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVS 892
Query: 1867 RDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE-LTLQWTEG 1925
R V GP + P EG P +PR V + E + L+W
Sbjct: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFRVRQPNLETINLEWDHP 951
Query: 1926 HSGDTPTTGYVIE-ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEA 1984
+ GY ++ + + V++ + T +T+ + Y F + A +
Sbjct: 952 EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQ--RTDPVSRYRFTLSARTQV 1009
Query: 1985 GYGE--------PSNPSTAVSAQV--EAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQ 2034
G GE P N +T +A +A + WF+ +M +L+V++L++ + +
Sbjct: 1010 GSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSR 1069
Query: 2035 NKKY 2038
KY
Sbjct: 1070 GGKY 1073
Score = 58.2 bits (139), Expect = 9e-08
Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 50/339 (14%)
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASG 441
+ +PP T + + + + I C+A G P P+ W +++ + ++PR +
Sbjct: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 442 GLRIQKL----RPED-SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
G + RPE+ G +QCFA N+ G ++ + +P++ + +D V +G
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
Query: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AGNYTC 553
L+C G P P I W + + R+ + +G L + V +QD +Y+C
Sbjct: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG---HNGDLYFSNVMLQDMQTDYSC 207
Query: 554 YA----ANTEGSLNASATLTV-----WNRTSIVHPPE----------------------D 582
A +T N TL V +N +S+ + P+
Sbjct: 208 NARFHFTHTIQQKN-PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 583 HVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI 642
+V++G L C A+ P + + K ++ PS ++ + +L I+ D
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKF-ENFNKALRITNVSEEDS 322
Query: 643 GDYSCEIVSEGGNDSRMARLEVIELPH---SPQNLLVSP 678
G+Y C ++ G+ + V P+ P+NL+++P
Sbjct: 323 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361
Score = 57.8 bits (138), Expect = 1e-07
Identities = 88/392 (22%), Positives = 146/392 (37%), Gaps = 36/392 (9%)
Query: 114 QIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI-----IPSLQKLDAGFYR 168
Q+ L G L+L C+A G + W + +L + ++++ I ++ + D+G Y
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 326
Query: 169 CVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
C+ N+MG+ ++ V+V ++D + ++ G L + P+P V W
Sbjct: 327 CLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRL-VCRANGNPKPTVQWMVN 384
Query: 229 GHKI--IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVG 286
G + P N + ++ T S Y NE +G + F+ +
Sbjct: 385 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE-HGYLLANAFVSVL------ 437
Query: 287 TPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF--G 344
+ P ++ P V + T L+C P+ L G + G +
Sbjct: 438 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 494
Query: 345 RRLTISNPTSADTGPYVCEAA-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403
L I D G Y C A + G A R L + +P PE ++ A T
Sbjct: 495 GSLEIKMIRKEDQGIYTCVATNILGKAENQVR----LEVKDPTRIYRMPEDQV-ARRGTT 549
Query: 404 VDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFAS 461
V + C+ P T+ W KD + + N K L I + D G + C AS
Sbjct: 550 VQLECRVKHDPSLKLTVSWLKDDEPL-YIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
Query: 462 NEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
E + YL V RP D +TD
Sbjct: 607 TELDQDLAKAYLTVLG----RPDRPRDLELTD 634
Score = 35.4 bits (80), Expect = 0.63
Identities = 45/193 (23%), Positives = 72/193 (37%), Gaps = 16/193 (8%)
Query: 464 GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASG 523
GG I+ +D+T + Q D V ++ CE G P P+ W R +
Sbjct: 22 GGAIEIP--MDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF--N 77
Query: 524 SVRIPRFMLLESGGLQIAPVFI-----QDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
+ PR + G + + G Y C+A N G+ S + + S +
Sbjct: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLW 136
Query: 579 PPE--DHVVI-KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
P E D VV+ +G TL C P + ++ + + R+ +G L S
Sbjct: 137 PKENLDPVVVQEGAPLTLQCNP--PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
Query: 636 QTWSGDI-GDYSC 647
D+ DYSC
Sbjct: 195 NVMLQDMQTDYSC 207
Score = 34.7 bits (78), Expect = 1.1
Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 4/110 (3%)
Query: 667 LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSP--WKVHLSNVGPE 724
+P +P+ V + + L W P N ++ Y ++ N K + N P
Sbjct: 927 VPSAPRRFRV--RQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPN 984
Query: 725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKN 774
T TV P Y+F + A +VG G+ E S E P+A N
Sbjct: 985 QTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 265 bits (676), Expect = 5e-70
Identities = 242/938 (25%), Positives = 389/938 (41%), Gaps = 55/938 (5%)
Query: 165 GFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQ-GRAAILNLLPITSYPRPQV 223
G Y+C RN+ G L + +QV+ + + V Q G L P P P +
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVI 167
Query: 224 TWFREGHKIIPSNRIAITLEN-----QLVILATTTSD----AGAYYVQAVNEKNG----- 269
W + I ++ N V+L +D A ++ + +KN
Sbjct: 168 FWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
Query: 270 -----ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPV 322
N +S H + G E P+ + P G S +V + LECIAS P
Sbjct: 228 LTNHPYNDSSLRNHPDMYSARGVAER-TPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 286
Query: 323 EDLSVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
D++ W + G + S +F + L I+N + D+G Y C L + R T
Sbjct: 287 PDIA--WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC---LASNKMGSIRHTIS 341
Query: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI-SRLQNPRYKVL 438
+ + PY+ EP++ I A E+ + C+A G P PT+QW + + S NP +V
Sbjct: 342 VRVKAAPYWLDEPKNLILAPGEDG-RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV- 399
Query: 439 ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTA 497
A + + + ++QC SNE G + + ++ V ++ P + + R V
Sbjct: 400 AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 459
Query: 498 ILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
L C G+P P + W + ++ + + E+G L+I + +D G YTC A N
Sbjct: 460 RLDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
Query: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALT 617
G L V + T I PED V +GTT L C HDP + L W KD+
Sbjct: 517 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD---E 573
Query: 618 PSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
P + ++D SL I D G Y+C +E D A L V+ P P++L ++
Sbjct: 574 PLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELT 633
Query: 678 PNSSHSHAVVLSWVRPFDGNSPILYYIVELSENN-SPWKVHLSNVGPEMTGVTVSGLTPA 736
+ S V L+W+ NSPI Y+V+ E+ P H + P V L+P
Sbjct: 634 DLAERS--VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPY 691
Query: 737 RTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETE 796
YQFRV A+NEVG S + R PP + P ++ G ++ + W P T
Sbjct: 692 VNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATS 751
Query: 797 HNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF 856
G YI+++R + N+T Y +V ++ YEI+V A N G G
Sbjct: 752 AFGPNLRYIVKWRRRETREAW--NNVTVWGSRY-VVGQTPVYVPYEIRVQAENDFGKGPE 808
Query: 857 SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPE 916
+V Y+ + P A P V+ +NST I WN + G + Y+ W +
Sbjct: 809 PESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLL 868
Query: 917 A---VTVVTIAPDFHGVH-HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKP 972
V+ F G G ++ L ++ Y ++ GDGP S + T E P
Sbjct: 869 KNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVP 928
Query: 973 GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG--RNDSRLTHTLNSTTHEY 1030
A + ++ + W P NGI+ GY + + + + ++ + ++
Sbjct: 929 SAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKF 988
Query: 1031 KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPD 1068
+Q ++ Y ++A T VG+G + T S PP+
Sbjct: 989 TVQRTDPVSRYRFTLSARTQVGSG--EAVTEESPAPPN 1024
Score = 130 bits (326), Expect = 2e-29
Identities = 107/420 (25%), Positives = 185/420 (44%), Gaps = 25/420 (5%)
Query: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
P P +L +++++ RS L + PG + I+ ++V+ + D+ + ++ P
Sbjct: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEE----DQFQPGVWHDHSKYPG 679
Query: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
+ + L+PY +Y+FR+ +N VG S S S +T APP+ P V + +
Sbjct: 680 SVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNN 739
Query: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249
+ + W P+ + G ++ Y +K+ R + + + V + + + ++ YE
Sbjct: 740 MEITWTPMNATSAFG--PNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPVYVPYE 794
Query: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
+++QA N G GP E V G + E P AAP V ++ST I L W V G +
Sbjct: 795 IRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQL 854
Query: 1310 LGYKILF-RAKDL-----DPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGV 1363
Y+ + R L + R +++ L + Y+L+++ G+G
Sbjct: 855 REYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG- 913
Query: 1364 PSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPH 1423
P + T + P P R + L ++ + W PE PNGI++GY + Y + +
Sbjct: 914 PRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKV 973
Query: 1424 TFTTVE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
VE +FT P S Y F LSA+T+ G GE + E PAPP E
Sbjct: 974 GKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAV--------TEESPAPPNE 1025
Score = 129 bits (324), Expect = 3e-29
Identities = 116/458 (25%), Positives = 179/458 (39%), Gaps = 46/458 (10%)
Query: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRE--LPRGEWQTYSSSISH 1533
RP PR+L + ++ RS+RL W+PG SPI + +Q E G W +S
Sbjct: 623 RPDRPRDLEL--TDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGS 680
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+A + RL P+ +Y+ R+ A N++G S S +E T P PG V +
Sbjct: 681 VNSAVL--RLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKN 738
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
++ I W P S G Y + +R E +T S V
Sbjct: 739 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNN--------------VTVWGSRYVV 784
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ Y YE+ + A N G+ P V + GE P AP V+V +
Sbjct: 785 GQTPV-----------YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM 833
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVRLKNLTS- 1770
++ + + W+ ++ G ++ Y+ YYW S +N K P RL+ + S
Sbjct: 834 NSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSR 893
Query: 1771 ---HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
++ Y + + N GDGP+S+ ++ T + P AP + T+N+ W P
Sbjct: 894 LFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEH 953
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYG 1887
NGI+ GY + Y + V K + N Q V+ Y F + ART
Sbjct: 954 PNGIMIGYTLKYVAFNGTK-VGKQIVENFSPN-QTKFTVQRTDPVSRYRFTLSART---- 1007
Query: 1888 PELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEG 1925
Q E SP P + A T W G
Sbjct: 1008 ---QVGSGEAVTEESPAPPNEAYTNNQADIATQGWFIG 1042
Score = 74.7 bits (182), Expect = 9e-13
Identities = 96/423 (22%), Positives = 164/423 (38%), Gaps = 47/423 (11%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-----HTFTTVEVGA 1432
P P L ++ SVR+ W P + N I Y + + P H+ V +
Sbjct: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS 683
Query: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL--VPQAEV 1490
V + L+P Y FR+ A G P ++ + R APP V
Sbjct: 684 AVLR-----LSPYVNYQFRVIAINEVGSSHP---SLPSERYRTSGAPPESNPGDVKGEGT 735
Query: 1491 TARSLRLQWVP--GSDGASP-IRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFT 1547
++ + W P + P +RY R R W ++++ + VV + +
Sbjct: 736 RKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW----NNVTVWGSRYVVGQTPVYV 791
Query: 1548 SYKLRLKATNDIGDSDFSSETEAVTTL--QDVPGEPPGSVSATPHTTSSVLIQWQPPRDE 1605
Y++R++A ND G E E+V +D P P V ++++ +QW +
Sbjct: 792 PYEIRVQAENDFGKGP---EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD 848
Query: 1606 SLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELT 1665
++ G L+ YR YY E+ LKN ++ Q+SF ++
Sbjct: 849 TVQGQLREYRAYY---------WRESSLLKN--LWVSQKRQQASFPGDRLRGV-----VS 892
Query: 1666 HLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPP 1725
L Y Y++ M N G+ P S E E P+ AP+ +V + + WD
Sbjct: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWD-- 949
Query: 1726 PPESQNGNIQGYKIYYWEADSQNETEKMKVLFLP-EPVVRLKNLTSHTKYLVSISAFNAA 1784
PE NG + GY + Y + +++ F P + ++ ++Y ++SA
Sbjct: 950 HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQV 1009
Query: 1785 GDG 1787
G G
Sbjct: 1010 GSG 1012
Score = 60.1 bits (144), Expect = 2e-08
Identities = 102/480 (21%), Positives = 182/480 (37%), Gaps = 49/480 (10%)
Query: 1577 VPGEP--PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTL 1634
V G P P + T SV + W P ++ N + Y + + E +++ G +
Sbjct: 620 VLGRPDRPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEEDQFQPGVWHD---- 673
Query: 1635 KNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEV 1694
H++ +VNS+ + L Y Y+ + A N +G S S P E
Sbjct: 674 ------HSKYPG-----SVNSA-------VLRLSPYVNYQFRVIAINEVGSSHPSLPSER 715
Query: 1695 FVGEAAPAMA-PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKM 1753
+ AP + P +V+ + +E+TW P S G Y I W E
Sbjct: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY-IVKWRRRETREAWNN 774
Query: 1754 KVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSE 1812
++ VV + + Y + + A N G GP+ + G + + P AP+ +
Sbjct: 775 VTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRV 832
Query: 1813 ITSTTLNVSWGEPAA--ANGILQGYRVVY----EPLAPVQGVSKVVTVEVRGNWQRWLKV 1866
+ ST +++ W + G L+ YR Y L + K G+ R +
Sbjct: 833 MNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVS 892
Query: 1867 RDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE-LTLQWTEG 1925
R V GP + P EG P +PR V + E + L+W
Sbjct: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFRVRQPNLETINLEWDHP 951
Query: 1926 HSGDTPTTGYVIE-ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEA 1984
+ GY ++ + + V++ + T +T+ + Y F + A +
Sbjct: 952 EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQ--RTDPVSRYRFTLSARTQV 1009
Query: 1985 GYGE------PSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY 2038
G GE P+ P+ A + +A + WF+ +M +L+V++L++ + + KY
Sbjct: 1010 GSGEAVTEESPAPPNEAYTNN-QADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKY 1068
Score = 58.2 bits (139), Expect = 9e-08
Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 50/339 (14%)
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASG 441
+ +PP T + + + + I C+A G P P+ W +++ + ++PR +
Sbjct: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 442 GLRIQKL----RPED-SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
G + RPE+ G +QCFA N+ G ++ + +P++ + +D V +G
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
Query: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AGNYTC 553
L+C G P P I W + + R+ + +G L + V +QD +Y+C
Sbjct: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG---HNGDLYFSNVMLQDMQTDYSC 207
Query: 554 YA----ANTEGSLNASATLTV-----WNRTSIVHPPE----------------------D 582
A +T N TL V +N +S+ + P+
Sbjct: 208 NARFHFTHTIQQKN-PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 583 HVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI 642
+V++G L C A+ P + + K ++ PS ++ + +L I+ D
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKF-ENFNKALRITNVSEEDS 322
Query: 643 GDYSCEIVSEGGNDSRMARLEVIELPH---SPQNLLVSP 678
G+Y C ++ G+ + V P+ P+NL+++P
Sbjct: 323 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361
Score = 57.8 bits (138), Expect = 1e-07
Identities = 88/392 (22%), Positives = 146/392 (37%), Gaps = 36/392 (9%)
Query: 114 QIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI-----IPSLQKLDAGFYR 168
Q+ L G L+L C+A G + W + +L + ++++ I ++ + D+G Y
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 326
Query: 169 CVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
C+ N+MG+ ++ V+V ++D + ++ G L + P+P V W
Sbjct: 327 CLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRL-VCRANGNPKPTVQWMVN 384
Query: 229 GHKI--IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVG 286
G + P N + ++ T S Y NE +G + F+ +
Sbjct: 385 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE-HGYLLANAFVSVL------ 437
Query: 287 TPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF--G 344
+ P ++ P V + T L+C P+ L G + G +
Sbjct: 438 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 494
Query: 345 RRLTISNPTSADTGPYVCEAA-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403
L I D G Y C A + G A R L + +P PE ++ A T
Sbjct: 495 GSLEIKMIRKEDQGIYTCVATNILGKAENQVR----LEVKDPTRIYRMPEDQV-ARRGTT 549
Query: 404 VDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFAS 461
V + C+ P T+ W KD + + N K L I + D G + C AS
Sbjct: 550 VQLECRVKHDPSLKLTVSWLKDDEPL-YIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
Query: 462 NEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
E + YL V RP D +TD
Sbjct: 607 TELDQDLAKAYLTVLG----RPDRPRDLELTD 634
Score = 35.4 bits (80), Expect = 0.63
Identities = 45/193 (23%), Positives = 72/193 (37%), Gaps = 16/193 (8%)
Query: 464 GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASG 523
GG I+ +D+T + Q D V ++ CE G P P+ W R +
Sbjct: 22 GGAIEIP--MDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF--N 77
Query: 524 SVRIPRFMLLESGGLQIAPVFI-----QDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
+ PR + G + + G Y C+A N G+ S + + S +
Sbjct: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLW 136
Query: 579 PPE--DHVVI-KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
P E D VV+ +G TL C P + ++ + + R+ +G L S
Sbjct: 137 PKENLDPVVVQEGAPLTLQCNP--PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
Query: 636 QTWSGDI-GDYSC 647
D+ DYSC
Sbjct: 195 NVMLQDMQTDYSC 207
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 261 bits (668), Expect = 4e-69
Identities = 253/990 (25%), Positives = 412/990 (41%), Gaps = 83/990 (8%)
Query: 122 LVLTCLAEGSWPLEFKWMRD--------DSELTTYSSEYKYIIPSLQKLDA----GFYRC 169
+V+ C A+G P F W R+ D +T II + + A G Y+C
Sbjct: 58 IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQC 117
Query: 170 VVRNRMGALLQRKSEVQVAYMGSFMDTDQRK---TVSQGRAAILNLLPITSYPRPQVTWF 226
RN GA + + + V S + T ++ T+ G++ +L P P P + W
Sbjct: 118 TARNERGAAVS--NNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWM 175
Query: 227 REGHKIIP-SNRIAITLENQLVILATTTSDAGAYYV--------QAVNEKN--------- 268
+ +P S R++ L L D Y+ Q + +K
Sbjct: 176 DNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISV 235
Query: 269 GENKTSPFIHLSIARDVGTPETMA--PTIVVPPGNRS--VVAGSSETTLECIASARPVED 324
E + +LS G + PT + P GN S + +LECIA P
Sbjct: 236 DELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTP- 294
Query: 325 LSVTW-KRNGV--RITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLF 381
+ W K +G+ + + +F + L I + + AD+G Y C A +A T +
Sbjct: 295 -IIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAK---NALGAIHHTISVR 350
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASG 441
+ PY+ P++ + + E+ I C+A G P P + W + + I + + +
Sbjct: 351 VKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGD 409
Query: 442 GLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTAILR 500
+ ++ S ++QC ASNE G + + +++V P + T V A+L
Sbjct: 410 TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 469
Query: 501 CEVSGAPKPAITWKRENHILASGS-VRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
C G+P P I W + A GS + ++L E+G L+I G YTC A N
Sbjct: 470 CAFFGSPLPTIEWFKG----AKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKL 525
Query: 560 GSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPS 619
G L + + T IV PE VV +G+ + C HD +SL +W KDN L
Sbjct: 526 GMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL--P 583
Query: 620 STSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPN 679
S R V+KD L+++ D G Y+C + + S A L V+++P+ P +L ++
Sbjct: 584 SDERFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQ 642
Query: 680 SSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSG---LTPA 736
S V LSW D NSPI +I+E + + K L + E++G + L+P
Sbjct: 643 LDKS--VQLSWTPGDDNNSPITKFIIEYED--AMHKPGLWHHQTEVSGTQTTAQLKLSPY 698
Query: 737 RTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETE 796
Y FRV AVN +G+ S + + + P P + G ++++ W+P E
Sbjct: 699 VNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFE 758
Query: 797 HNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF 856
NG Y + +R G+ + ++ V+ +V+ + Y I+V A N G
Sbjct: 759 SNGPGLQYKVSWRQK--DGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPE 816
Query: 857 SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPE 916
V ++ + +P P NV+ VNST + W+P P + I G QGY++ W +
Sbjct: 817 PAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSS 876
Query: 917 AVTVVTIAP---DFHGVH-HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKP 972
I F G HG + L+ F+ Y +V G+GP S ++ T E P
Sbjct: 877 KRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVP 936
Query: 973 GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLN-------- 1024
A L SL + W P NGI+T Y + ++ TH L
Sbjct: 937 SAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINS-----THELGPLVDLKIP 991
Query: 1025 STTHEYKIQGLSSLTTYTIDVAAVTAVGTG 1054
+ + ++ L+ T Y A T+ G+G
Sbjct: 992 ANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1021
Score = 152 bits (384), Expect = 4e-36
Identities = 115/416 (27%), Positives = 188/416 (45%), Gaps = 39/416 (9%)
Query: 1477 PAPPREL-LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPR--GEWQTYSSSISH 1533
P PP +L L Q + +S++L W PG D SPI F ++ + G W +
Sbjct: 631 PNPPFDLELTDQLD---KSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGT 687
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ TA + +L P+ +Y R+ A N IG S S +E T P + P +V
Sbjct: 688 QTTAQL--KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPD 745
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
+++I W+P NG Y++ +R+ + G + T + + A S V
Sbjct: 746 NLVITWKPLNGFESNGPGLQYKVSWRQKD-----GDDEWT--------SVVVANVSKYIV 792
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ + T + Y + + A N +G +P A V GE P +AP NV+V +
Sbjct: 793 SGTPT-----------FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVV 841
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK----MKVLFLPEPVVR--LKN 1767
++ EV WDP P +S G++QGY+IYYW+ S ++ + K+L L
Sbjct: 842 NSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPG 901
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L + Y +++ N G+GP S + T + P APS L T +L + W P+
Sbjct: 902 LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSH 961
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART 1883
NGIL Y + Y+P+ + +V +++ N RW +++L Y F A+T
Sbjct: 962 PNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRW-TLKNLNFSTRYKFYFYAQT 1016
Score = 147 bits (370), Expect = 1e-34
Identities = 116/426 (27%), Positives = 196/426 (46%), Gaps = 23/426 (5%)
Query: 1056 VTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDE 1115
V++S + S V D+P P +L +++ +S L + PG D + I+++I+E + D
Sbjct: 619 VSASAVLSVV--DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYE-----DA 671
Query: 1116 EEWVTLYEEENEPDA-QMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPD 1174
L+ + E Q L+PY +Y FR+ VN +G S S +S T + PD
Sbjct: 672 MHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPD 731
Query: 1175 VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLE 1234
PT+V + +L + W PL + NG + Y++ + + D + VV++
Sbjct: 732 KNPTAVEGLGSEPDNLVITWKPLNGFESNG--PGLQYKVSWRQKDGDDEWTSVVVAN--V 787
Query: 1235 REFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQIL 1294
++ + ++ Y +++QA N +G P VV G + E +P AP NV V+ST
Sbjct: 788 SKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAE 847
Query: 1295 LTWTSVPEQDQNGLILGYKILF-RAKDLDPEPRSHI------VRGNHTQSALLAGLRKFV 1347
+ W VP + G + GY+I + + + R HI +G+ T +L GL F
Sbjct: 848 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTH-GMLPGLEPFS 906
Query: 1348 LYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGI 1407
Y L V G G P++P + T + P P L L S+ + W PP PNGI
Sbjct: 907 HYTLNVRVVNGKGEG-PASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI 965
Query: 1408 ILGYQIAYRLASSSPH--TFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLE 1465
+ Y + Y+ +S+ +++ A ++T +L + Y F A+T G G +
Sbjct: 966 LTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQIT 1025
Query: 1466 ATVITT 1471
+TT
Sbjct: 1026 EEAVTT 1031
Score = 105 bits (263), Expect = 4e-22
Identities = 114/421 (27%), Positives = 172/421 (40%), Gaps = 37/421 (8%)
Query: 1376 DAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP---HTFTTVEVGA 1432
D P PP L + SV++ W P ++ N I + I Y A P H T V
Sbjct: 629 DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQ 688
Query: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA 1492
T Q L+P Y FR+ A G P EA+ K P V
Sbjct: 689 TTAQLK---LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP-DKNPTAVEGLGSEP 744
Query: 1493 RSLRLQWVP--GSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYK 1550
+L + W P G + P + + R+ + ++S + + +V F Y
Sbjct: 745 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD--EWTSVVVANVSKYIVSGTPTFVPYL 802
Query: 1551 LRLKATNDIGDSDFSSETEAVT--TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLN 1608
++++A ND+G F+ E V + +D+P PG+V ++ + W P +S+
Sbjct: 803 IKVQALNDMG---FAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIR 859
Query: 1609 GLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668
G LQGYRIYY + T++ + +N H E T S T M L L+
Sbjct: 860 GHLQGYRIYYWK--------TQSSSKRN--RRHIE----KKILTFQGSKTHGM--LPGLE 903
Query: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728
+ Y + + N GE PAS P VF AP ++++ T L + WD PP
Sbjct: 904 PFSHYTLNVRVVNGKGEGPAS-PDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPS 960
Query: 1729 SQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVR--LKNLTSHTKYLVSISAFNAAGD 1786
NG + Y + Y +S +E + L +P R LKNL T+Y A +AG
Sbjct: 961 HPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGS 1020
Query: 1787 G 1787
G
Sbjct: 1021 G 1021
Score = 92.8 bits (229), Expect = 3e-18
Identities = 135/595 (22%), Positives = 225/595 (37%), Gaps = 66/595 (11%)
Query: 1565 SSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYE 1624
S AV ++ DVP PP + T SV + W P D N + + I Y + ++
Sbjct: 618 SVSASAVLSVVDVPN-PPFDLELTDQLDKSVQLSWTPGDDN--NSPITKFIIEYEDAMHK 674
Query: 1625 AGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIG 1684
G + S T T +L L Y Y + A N IG
Sbjct: 675 PGLWHHQTEV---------------------SGTQTTAQLK-LSPYVNYSFRVMAVNSIG 712
Query: 1685 ESPASAPVEVFVGEAA-PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWE 1743
+S S E ++ +A+ P P V+ L +TW P NG YK+ + +
Sbjct: 713 KSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ 772
Query: 1744 ADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPG 1803
D +E + V + + +V + YL+ + A N G P+ G + + P
Sbjct: 773 KDGDDEWTSVVVANVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPM 830
Query: 1804 -APSFLAFSEITSTTLNVSWGEPA---AANGILQGYRVVYEPLAPVQGVSKVVT--VEVR 1857
AP + + + ST V W +P + G LQGYR+ Y Q SK +E +
Sbjct: 831 VAPGNVRVNVVNSTLAEVHW-DPVPLKSIRGHLQGYRIYYWK---TQSSSKRNRRHIEKK 886
Query: 1858 GNWQRWLKVRDLTKGVTYF--FRVQARTIT---YGPELQANITAGPAEGSPGSPRDV-LV 1911
+ K + G+ F + + R + GP + P EG P +P + +V
Sbjct: 887 ILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTP-EGVPSAPSSLKIV 945
Query: 1912 TKSASELTLQWTEGHSGDTPTTGYVIEARP--SDEGLWDMFVKDIPRSATSYTLSLDKLR 1969
+ LTL+W + T Y ++ +P S L + IP + T +TL L
Sbjct: 946 NPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLK--NLN 1003
Query: 1970 QGVTYEFRVVAVNEAGYGEPSNPSTAVS-----AQVEAPFYEEWWFLLVMALSSLIVILL 2024
Y+F A AG G + A + + WF+ +M +L++++L
Sbjct: 1004 FSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILIL 1063
Query: 2025 VVFALVLHGQNKKY-----KNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSK 2079
++ + + KY ++ I M+E D+G F + H +K
Sbjct: 1064 LIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKE----DDGTFGEYSDAEDHKPLKKGSRT 1119
Query: 2080 KNGTRSPPRPSPGGLHYSDEDICNKYN--GAVLTESVSLKEKS-ADASESEATDS 2131
+ S L E + ++N G+ + + KEK A+ +ES S
Sbjct: 1120 PSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPS 1174
Score = 84.7 bits (208), Expect = 9e-16
Identities = 168/795 (21%), Positives = 304/795 (38%), Gaps = 91/795 (11%)
Query: 117 LEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQ-----KLDAGFYRCVV 171
L GN L L C+AEG W ++D L + YK +LQ + D+G Y+C+
Sbjct: 277 LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIA 336
Query: 172 RNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHK 231
+N +GA + V+V ++ Q +S G L + P+P+++W G
Sbjct: 337 KNALGA-IHHTISVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVP 394
Query: 232 I-IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPET 290
I I + + ++ +I + + A Y + + G + F+++ + P
Sbjct: 395 IEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNV-----LAEP-- 447
Query: 291 MAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTIS 350
P I+ P V + L+C P+ + G + ++ T+
Sbjct: 448 --PRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLE 505
Query: 351 NPTSA--DTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGC 408
P + TG Y C A + A+ L I +P + +PE + + V C
Sbjct: 506 IPVAQKDSTGTYTCVAR---NKLGMAKNEVHLEIKDPTWIVKQPEYAV-VQRGSMVSFEC 561
Query: 409 QAM--GVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGE 466
+ T+ W KD L + + L + + +DSG + C A+
Sbjct: 562 KVKHDHTLSLTVLWLKDN---RELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDS 618
Query: 467 IQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRC-----EVSGAPKPAITWKRENHILA 521
+ L V ++ P D +TD + ++ + + +P + E+ +
Sbjct: 619 VSASAVLSVVDV----PNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHK 674
Query: 522 SGSVRIPRFMLLESGGLQIAPVFIQDAGNYT--CYAANTEG-SLNASATLTVWNRTSIVH 578
G + SG A + + NY+ A N+ G SL + A+ + S
Sbjct: 675 PG---LWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKAS--E 729
Query: 579 PPEDHVVIKG----------TTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEK 628
P ++ ++G T L+ ++ P + + W++ + + +VV
Sbjct: 730 PDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKD---GDDEWTSVVVAN 786
Query: 629 DGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNL-LVSP--------N 679
++S T Y ++ + ND A + + HS ++L +V+P N
Sbjct: 787 VSKYIVSGT--PTFVPYLIKV--QALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVN 842
Query: 680 SS----HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVH---LSNVGPEMTGVTVSG 732
S+ H V L +R I Y+ + S + + L+ G + G+ + G
Sbjct: 843 STLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGM-LPG 901
Query: 733 LTPARTYQFRVCAVNEVGRGQYSAETSRLM-LPEEPPSAPPKNIVASGRTNQSIMVQWQP 791
L P Y V VN G+G+ A R+ PE PSA P ++ T S+ ++W P
Sbjct: 902 LEPFSHYTLNVRVVN--GKGEGPASPDRVFNTPEGVPSA-PSSLKIVNPTLDSLTLEWDP 958
Query: 792 PPETEHNGVLRGYILRYRLAGLP---GEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAY 848
P + NG+L Y L+Y+ G I + + + L +L T+Y+ A
Sbjct: 959 P--SHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTL-KNLNFSTRYKFYFYAQ 1015
Query: 849 NGAGLG--VFSRAVT 861
AG G + AVT
Sbjct: 1016 TSAGSGSQITEEAVT 1030
Score = 65.9 bits (159), Expect = 4e-10
Identities = 77/342 (22%), Positives = 133/342 (38%), Gaps = 50/342 (14%)
Query: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA 439
L +++PP T + + E + I C+A G P P+ W ++ ++P +
Sbjct: 34 LDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 93
Query: 440 SGGLRIQKLRPED-----SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTD 493
G I + E G++QC A NE G ++ + + +P++T+ ++ T+
Sbjct: 94 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQS 153
Query: 494 GMTAILRCEVS-GAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA-GNY 551
G + +L C G P P I W + S R+ + + +G L + V +D +Y
Sbjct: 154 GQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGL---NGDLYFSNVLPEDTREDY 210
Query: 552 TCYA-----------------------ANTEGSLNASATLTVWNRTSIVHPP-------- 580
CYA N + N S T ++S PP
Sbjct: 211 ICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 270
Query: 581 -EDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWS 639
+ ++G +L C A P + W K++ L + T EK +L I
Sbjct: 271 ASNKEELRGNVLSLECIAEGLPTPII--YWAKEDGMLPKNRTVYKNFEK--TLQIIHVSE 326
Query: 640 GDIGDYSCEIVSEGGNDSRMARLEVIELPH---SPQNLLVSP 678
D G+Y C + G + V P+ +PQNL++SP
Sbjct: 327 ADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSP 368
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 260 bits (664), Expect = 1e-68
Identities = 251/1010 (24%), Positives = 419/1010 (41%), Gaps = 60/1010 (5%)
Query: 84 WALLALQLHLLRALAQDDVAPYFKTEPGLPQIHL-EGNRLVLTCLAEGSWPLEFKWMRD- 141
W LL LL + ++ + P TE ++ + + + L C A G ++F+W RD
Sbjct: 9 WPLLLCSPCLLIQIPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDG 68
Query: 142 -------DSELTTYSSEYKYIIP------SLQKLDAGFYRCVVRNRMGALLQRKSEVQVA 188
+ +T Y S + + + G YRC N++G + + +
Sbjct: 69 VHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAE 128
Query: 189 YMGSF-MDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKII---PSNRIAITLEN 244
+ +T + V +G + +L P S ++ W KI+ R+ +
Sbjct: 129 GAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNS--KILHIKQDERVTMGQNG 186
Query: 245 QLVILATTTSDAGAYYVQAVNEKNGEN--KTSPFIHLSIARDVGTPETMAPTIVVPPGNR 302
L TSD + Y+ + + P I L + + + P ++ P +
Sbjct: 187 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEP-IDLRV-KATNSMIDRKPRLLFPTNSS 244
Query: 303 S--VVAGSSETTLECIASARPVEDLSVTWKRNGV-----RITSGLHSFGRRLTISNPTSA 355
S V LECIA P ++ W R R+T H+ + L +
Sbjct: 245 SHLVALQGQPLVLECIAEGFPTP--TIKWLRPSGPMPADRVTYQNHN--KTLQLLKVGEE 300
Query: 356 DTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPL 415
D G Y C L ++ AR ++ + PY+ +P+S + ET + CQ G P
Sbjct: 301 DDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQ 356
Query: 416 PTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDV 475
P + W + I + L + + G L + ++P D+ + QC A N G + + Y+ V
Sbjct: 357 PEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYV 416
Query: 476 TNI-APVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLE 534
+ A + T G TA L C+ GAP P++ W E+ + ++ RF
Sbjct: 417 VQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDED---GTTVLQDERFFPYA 473
Query: 535 SGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLH 594
+G L I + D G Y C AAN + ++ A L V + T I P + KG+ T
Sbjct: 474 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT 533
Query: 595 CGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGG 654
C A+ DP + W+ D L S +DG L+I D G+YSC +E
Sbjct: 534 CQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELD 593
Query: 655 NDSRMARLEVIELPHSPQNLLVSPNSSHSHAVV-LSWVRPFDGNSPILYYIVELSENN-S 712
A+L V+ P L++S + + V +SW D N+PI Y +E + +
Sbjct: 594 VVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMA 653
Query: 713 PWKVH-LSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAP 771
P K + L V T T+ L+P Y FRV A+N+ G G+ S + ++ PE P
Sbjct: 654 PEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKN 712
Query: 772 PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCL 831
P ++ G ++++ W+P + N Y +++R G G +Q++ ++ P + +
Sbjct: 713 PVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP---FLV 769
Query: 832 VTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWN 891
V++ + YEI+V A N G G + Y+ + P A P+ E +NS+ + W
Sbjct: 770 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 829
Query: 892 PPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITN-----LKKFTAYFT 946
P + G +GY + W + + I D H V + T+ L+ +++Y
Sbjct: 830 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKD-HVVVPANTTSVILSGLRPYSSYHL 888
Query: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQ 1006
V F G GP S T E PG L +TSL + WQ PL NG++TGY
Sbjct: 889 EVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYV 947
Query: 1007 ISWEVYGR-NDSRLTHTL-NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG 1054
+S+ +L+ L + + + LS Y + A T G G
Sbjct: 948 LSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG 997
Score = 154 bits (389), Expect = 9e-37
Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 21/405 (5%)
Query: 1070 PGAPSNLVISNI---SPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEEN 1126
PG LV+S++ + + + P D I ++ +E + + E+ W +L +
Sbjct: 607 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK-WYSLGKVPG 665
Query: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
+ L+ L+PY HY FR+ +N GP SP S + T +A P+ P V
Sbjct: 666 NQTSTTLK---LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 722
Query: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246
T++ + W PL +N V YR+++ + Q+VSD + ++
Sbjct: 723 TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 777
Query: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
YE+++QA N+ G GP +V G + E P A PE E ++S+ +L+ W V
Sbjct: 778 PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 837
Query: 1307 GLILGYKILF------RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
G + GY + + R + H+V +T S +L+GLR + Y L+V AF G
Sbjct: 838 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897
Query: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR-LAS 1419
+G P++ T + PG P L TS+ + WQPP NG++ GY ++Y L
Sbjct: 898 SG-PASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 955
Query: 1420 SSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL 1464
+ +R TDL+P Y F+L A T++G GE +
Sbjct: 956 GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAI 1000
Score = 146 bits (368), Expect = 3e-34
Identities = 223/1033 (21%), Positives = 392/1033 (37%), Gaps = 112/1033 (10%)
Query: 219 PRPQVTWFREGHKIIPSNRIAITL-----ENQLVILATTTSDAGAYYVQAVNEKNGENKT 273
P Q W R+G P + +T+ I ++ A + Q + NK
Sbjct: 58 PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 115
Query: 274 SPFIHLSIARDV-GTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRN 332
+ I G P+ T+ + V E+ + E L + W +
Sbjct: 116 GTAMSHEIRLMAEGAPKWPKETV------KPVEVEEGESVVLPCNPPPSAEPLRIYWMNS 169
Query: 333 GV-------RITSGLHSFGRRLTISNPTSADT-GPYVCEAALPGSAF----EP----ARA 376
+ R+T G + L +N ++D Y+C A PG+ EP +A
Sbjct: 170 KILHIKQDERVTMGQNG---NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKA 226
Query: 377 TAFLFIIEPPY-FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDA--ISISRLQNP 433
T + +P F S + A + + + C A G P PT++W + + + R+
Sbjct: 227 TNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQ 286
Query: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
+ L++ K+ ED G ++C A N G + H Y AP + +P
Sbjct: 287 NHNKT----LQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 341
Query: 494 GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTC 553
G TA L C+V G P+P +TW R N I + ++ + + G L ++ V D C
Sbjct: 342 GETARLDCQVQGRPQPEVTW-RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQC 399
Query: 554 YAANTEGSLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGATHDPRVSLRYVWKK 611
A N G L A+A + V + + ++ ++ ++G+TA L C A P S++++
Sbjct: 400 EARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL--- 456
Query: 612 DNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV---IELP 668
D T R +G+L I + D G Y C ++ N + MA L+V ++
Sbjct: 457 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 516
Query: 669 HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGV 728
P++ + S V + FD P L + + W+ G ++ +
Sbjct: 517 QGPRSTIEKKGSR----VTFTCQASFD---PSL-------QPSITWR----GDGRDLQEL 558
Query: 729 TVSGLTPARTYQFRVCAVNEVGRGQYSA---------ETSRLMLPEEPPSAPPKNIVASG 779
S + + +++ +G YS E+ +L P P+ +++
Sbjct: 559 GDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 618
Query: 780 R--TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII 837
T + V W P + HN + Y + + + E P L
Sbjct: 619 HLLTQSQVRVSWSPAED--HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 676
Query: 838 WTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQ 896
+ Y +V A N G G S + T T + P P +V+ E +T + W P
Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWM 736
Query: 897 FINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGD 956
N Y++ W I D V ++N F Y V + G
Sbjct: 737 DWNAPQVQYRV-QWRPQGTRGPWQEQIVSDPFLV----VSNTSTFVPYEIKVQAVNSQGK 791
Query: 957 GPPSTPQLVWTQEDKPGAVGHLSFTEILDTS-LKVSWQ--EPLEKNGIITGYQISWEVYG 1013
GP + ++ ED P A+ L EIL++S + V W+ + + G + GY ++ Y
Sbjct: 792 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT---YW 848
Query: 1014 RNDSRLTHT----------LNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
R S+ H+ + + T + GL ++Y ++V A G+G + T S+
Sbjct: 849 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST 908
Query: 1064 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYE 1123
P +PG P L + S S L+++P ++ +++ G + + L
Sbjct: 909 --PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQ---LSF 963
Query: 1124 EENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVR 1183
+P+ + + +L+P+ YRF+++ GP L D S
Sbjct: 964 NLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA--- 1020
Query: 1184 TASETSLRLRWVP 1196
TA E + WVP
Sbjct: 1021 TAGENYSVVSWVP 1033
Score = 132 bits (332), Expect = 4e-30
Identities = 133/576 (23%), Positives = 237/576 (41%), Gaps = 50/576 (8%)
Query: 1477 PAP-PRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV--RELPRGEWQTYSSSISH 1533
P P PR +L +T +R+ W P D +PI + ++ +E+ +W + +
Sbjct: 607 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 666
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ + + +L P+ Y R+ A N G + S +E V T + P + P V + T+
Sbjct: 667 QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 724
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
+++I W+P R N YR+ +R GT E F V
Sbjct: 725 NMVITWKPLRWMDWNAPQVQYRVQWRP------QGTRGPW--------QEQIVSDPFLVV 770
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+++ST + YE+ + A N G+ P + GE P P+ + L
Sbjct: 771 SNTST-----------FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL 819
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKV----LFLPEPV--VRLKN 1767
+S + V W P G+++GY + YW SQ + K + + +P V L
Sbjct: 820 NSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSG 879
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L ++ Y + + AFN G GP S+ T + PG P L ++T+L + W P +
Sbjct: 880 LRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLS 938
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYG 1887
NG+L GY + Y PL +G ++ +R R + DL+ + Y F++QA T G
Sbjct: 939 HNGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQA-TTKEG 995
Query: 1888 PELQANITAGPAEGSPGSP--RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEG 1945
P +A + G G ++ T + + W + +A ++G
Sbjct: 996 PG-EAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKG 1054
Query: 1946 LWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP-- 2003
+ + + + +SYT L+ YE + E + T + +V P
Sbjct: 1055 GASLSPQYVSYNQSSYTQW--DLQPDTDYEIHL--FKERMFRHQMAVKTNGTGRVRLPPA 1110
Query: 2004 -FYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY 2038
F E WF+ ++ L++++L++ + + KY
Sbjct: 1111 GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKY 1146
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 258 bits (660), Expect = 3e-68
Identities = 243/969 (25%), Positives = 402/969 (41%), Gaps = 59/969 (6%)
Query: 124 LTCLAEGSWPLEFKWMRD--------DSELTTYSSEYKYIIP------SLQKLDAGFYRC 169
L C A G ++F+W RD + +T Y S + + + G YRC
Sbjct: 55 LKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114
Query: 170 VVRNRMGALLQRKSEVQVAYMGSF-MDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
N++G + + + + +T + V +G + +L P S ++ W
Sbjct: 115 FASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNS 174
Query: 229 GHKII---PSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGEN--KTSPFIHLSIAR 283
KI+ R+ + L TSD + Y+ + + P I L + +
Sbjct: 175 --KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEP-IDLRV-K 230
Query: 284 DVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPVEDLSVTWKRNGV-----RI 336
+ P ++ P + S V LECIA P ++ W R R+
Sbjct: 231 ATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTP--TIKWLRPSGPMPADRV 288
Query: 337 TSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRI 396
T H+ + L + D G Y C L ++ AR ++ + PY+ +P+S +
Sbjct: 289 TYQNHN--KTLQLLKVGEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHL 343
Query: 397 SAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIF 456
ET + CQ G P P + W + I + L + + G L + ++P D+ +
Sbjct: 344 YGP-GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 457 QCFASNEGGEIQTHTYLDVTNI-APVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKR 515
QC A N G + + Y+ V + A + T G TA L C+ GAP P++ W
Sbjct: 403 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 462
Query: 516 ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS 575
E+ + ++ RF +G L I + D G Y C AAN + ++ A L V + T
Sbjct: 463 ED---GTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ 519
Query: 576 IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
I P + KG+ T C A+ DP + W+ D L S +DG L+I
Sbjct: 520 ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIH 579
Query: 636 QTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVV-LSWVRPF 694
D G+YSC +E A+L V+ P L++S + + V +SW
Sbjct: 580 SLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAE 639
Query: 695 DGNSPILYYIVELSENN-SPWKVH-LSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRG 752
D N+PI Y +E + +P K + L V T T+ L+P Y FRV A+N+ G G
Sbjct: 640 DHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPG 698
Query: 753 QYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG 812
+ S + ++ PE P P ++ G ++++ W+P + N Y +++R G
Sbjct: 699 EPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQG 758
Query: 813 LPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAP 872
G +Q++ ++ P + +V++ + YEI+V A N G G + Y+ + P A
Sbjct: 759 TRGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI 815
Query: 873 PQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHH 932
P+ E +NS+ + W P + G +GY + W + + I D H V
Sbjct: 816 PELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKD-HVVVP 874
Query: 933 GHITN-----LKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTS 987
+ T+ L+ +++Y V F G GP S T E PG L +TS
Sbjct: 875 ANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTS 933
Query: 988 LKVSWQEPLEKNGIITGYQISWEVYGR-NDSRLTHTL-NSTTHEYKIQGLSSLTTYTIDV 1045
L + WQ PL NG++TGY +S+ +L+ L + + + LS Y +
Sbjct: 934 LLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQL 993
Query: 1046 AAVTAVGTG 1054
A T G G
Sbjct: 994 QATTKEGPG 1002
Score = 154 bits (389), Expect = 9e-37
Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 21/405 (5%)
Query: 1070 PGAPSNLVISNI---SPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEEN 1126
PG LV+S++ + + + P D I ++ +E + + E+ W +L +
Sbjct: 612 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK-WYSLGKVPG 670
Query: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
+ L+ L+PY HY FR+ +N GP SP S + T +A P+ P V
Sbjct: 671 NQTSTTLK---LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 727
Query: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246
T++ + W PL +N V YR+++ + Q+VSD + ++
Sbjct: 728 TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 782
Query: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
YE+++QA N+ G GP +V G + E P A PE E ++S+ +L+ W V
Sbjct: 783 PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 1307 GLILGYKILF------RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
G + GY + + R + H+V +T S +L+GLR + Y L+V AF G
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR-LAS 1419
+G P++ T + PG P L TS+ + WQPP NG++ GY ++Y L
Sbjct: 903 SG-PASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 960
Query: 1420 SSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL 1464
+ +R TDL+P Y F+L A T++G GE +
Sbjct: 961 GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAI 1005
Score = 146 bits (368), Expect = 3e-34
Identities = 223/1033 (21%), Positives = 392/1033 (37%), Gaps = 112/1033 (10%)
Query: 219 PRPQVTWFREGHKIIPSNRIAITL-----ENQLVILATTTSDAGAYYVQAVNEKNGENKT 273
P Q W R+G P + +T+ I ++ A + Q + NK
Sbjct: 63 PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 120
Query: 274 SPFIHLSIARDV-GTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRN 332
+ I G P+ T+ + V E+ + E L + W +
Sbjct: 121 GTAMSHEIRLMAEGAPKWPKETV------KPVEVEEGESVVLPCNPPPSAEPLRIYWMNS 174
Query: 333 GV-------RITSGLHSFGRRLTISNPTSADT-GPYVCEAALPGSAF----EP----ARA 376
+ R+T G + L +N ++D Y+C A PG+ EP +A
Sbjct: 175 KILHIKQDERVTMGQNG---NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKA 231
Query: 377 TAFLFIIEPPY-FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDA--ISISRLQNP 433
T + +P F S + A + + + C A G P PT++W + + + R+
Sbjct: 232 TNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQ 291
Query: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
+ L++ K+ ED G ++C A N G + H Y AP + +P
Sbjct: 292 NHNKT----LQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 346
Query: 494 GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTC 553
G TA L C+V G P+P +TW R N I + ++ + + G L ++ V D C
Sbjct: 347 GETARLDCQVQGRPQPEVTW-RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQC 404
Query: 554 YAANTEGSLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGATHDPRVSLRYVWKK 611
A N G L A+A + V + + ++ ++ ++G+TA L C A P S++++
Sbjct: 405 EARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL--- 461
Query: 612 DNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV---IELP 668
D T R +G+L I + D G Y C ++ N + MA L+V ++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 669 HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGV 728
P++ + S V + FD P L + + W+ G ++ +
Sbjct: 522 QGPRSTIEKKGSR----VTFTCQASFD---PSL-------QPSITWR----GDGRDLQEL 563
Query: 729 TVSGLTPARTYQFRVCAVNEVGRGQYSA---------ETSRLMLPEEPPSAPPKNIVASG 779
S + + +++ +G YS E+ +L P P+ +++
Sbjct: 564 GDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623
Query: 780 R--TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII 837
T + V W P + HN + Y + + + E P L
Sbjct: 624 HLLTQSQVRVSWSPAED--HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 681
Query: 838 WTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQ 896
+ Y +V A N G G S + T T + P P +V+ E +T + W P
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWM 741
Query: 897 FINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGD 956
N Y++ W I D V ++N F Y V + G
Sbjct: 742 DWNAPQVQYRV-QWRPQGTRGPWQEQIVSDPFLV----VSNTSTFVPYEIKVQAVNSQGK 796
Query: 957 GPPSTPQLVWTQEDKPGAVGHLSFTEILDTS-LKVSWQ--EPLEKNGIITGYQISWEVYG 1013
GP + ++ ED P A+ L EIL++S + V W+ + + G + GY ++ Y
Sbjct: 797 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT---YW 853
Query: 1014 RNDSRLTHT----------LNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
R S+ H+ + + T + GL ++Y ++V A G+G + T S+
Sbjct: 854 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST 913
Query: 1064 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYE 1123
P +PG P L + S S L+++P ++ +++ G + + L
Sbjct: 914 --PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQ---LSF 968
Query: 1124 EENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVR 1183
+P+ + + +L+P+ YRF+++ GP L D S
Sbjct: 969 NLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA--- 1025
Query: 1184 TASETSLRLRWVP 1196
TA E + WVP
Sbjct: 1026 TAGENYSVVSWVP 1038
Score = 132 bits (332), Expect = 4e-30
Identities = 133/576 (23%), Positives = 237/576 (41%), Gaps = 50/576 (8%)
Query: 1477 PAP-PRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV--RELPRGEWQTYSSSISH 1533
P P PR +L +T +R+ W P D +PI + ++ +E+ +W + +
Sbjct: 612 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 671
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ + + +L P+ Y R+ A N G + S +E V T + P + P V + T+
Sbjct: 672 QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 729
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
+++I W+P R N YR+ +R GT E F V
Sbjct: 730 NMVITWKPLRWMDWNAPQVQYRVQWRP------QGTRGPW--------QEQIVSDPFLVV 775
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+++ST + YE+ + A N G+ P + GE P P+ + L
Sbjct: 776 SNTST-----------FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL 824
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKV----LFLPEPV--VRLKN 1767
+S + V W P G+++GY + YW SQ + K + + +P V L
Sbjct: 825 NSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSG 884
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L ++ Y + + AFN G GP S+ T + PG P L ++T+L + W P +
Sbjct: 885 LRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLS 943
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYG 1887
NG+L GY + Y PL +G ++ +R R + DL+ + Y F++QA T G
Sbjct: 944 HNGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQA-TTKEG 1000
Query: 1888 PELQANITAGPAEGSPGSP--RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEG 1945
P +A + G G ++ T + + W + +A ++G
Sbjct: 1001 PG-EAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKG 1059
Query: 1946 LWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP-- 2003
+ + + + +SYT L+ YE + E + T + +V P
Sbjct: 1060 GASLSPQYVSYNQSSYTQW--DLQPDTDYEIHL--FKERMFRHQMAVKTNGTGRVRLPPA 1115
Query: 2004 -FYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY 2038
F E WF+ ++ L++++L++ + + KY
Sbjct: 1116 GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKY 1151
Score = 107 bits (267), Expect = 1e-22
Identities = 194/807 (24%), Positives = 302/807 (37%), Gaps = 106/807 (13%)
Query: 106 FKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKL--- 162
F T + L+G LVL C+AEG KW+R + Y+ +LQ L
Sbjct: 244 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVG 303
Query: 163 --DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR 220
D G YRC+ N +G+ + V V ++ Q G A L+ + P+
Sbjct: 304 EEDDGEYRCLAENSLGS-ARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD-CQVQGRPQ 361
Query: 221 PQVTWFREGHKIIPSNRIAITLE-----NQLVILATTTSDAGAYYVQAVNEKNGENKTSP 275
P+VTW G IP +A + L++ SD +A N ++G +
Sbjct: 362 PEVTWRING---IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN-RHGLLLANA 417
Query: 276 FIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETT-LECIASARPVEDLSVTW-KRNG 333
+I++ P ++ N++ +A T L C A PV SV W +G
Sbjct: 418 YIYV----------VQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP--SVQWLDEDG 465
Query: 334 VRITSGLHSF---GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTA 390
+ F L I + + DTG Y C AA + A L + + T
Sbjct: 466 TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAA---NDQNNVTIMANLKVKDATQITQ 522
Query: 391 EPESRISAEVEETVDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKL 448
P S I + V CQA P P++ W D + L + + G L I L
Sbjct: 523 GPRSTIEKK-GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSL 581
Query: 449 RPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPK 508
D G + C AS E +++ L V V + PV V + + + +V +
Sbjct: 582 DYSDQGNYSCVASTELDVVESRAQLLV-----VGSPGPVPRLVLSDLHLLTQSQVRVSWS 636
Query: 509 PAITWKRENHILASGSVRIPRFMLLESGGLQIAP----VFIQDAGNYTCYAANTEGSLNA 564
PA E+H + I ++ +E ++AP + GN T ++
Sbjct: 637 PA-----EDH-----NAPIEKYD-IEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHY 685
Query: 565 SATLTVWNR--------------TSIVHPPEDHVVIKG----------TTATLHCGATHD 600
+ +T N+ T P ++ V +KG T L +
Sbjct: 686 TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNA 745
Query: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660
P+V R W+ T +V D L++S T + + + V+ G
Sbjct: 746 PQVQYRVQWRPQG---TRGPWQEQIV-SDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQ 801
Query: 661 RLEVIELPHSPQNL--LVSPNSSHSHAVVLSWVRPFD--------GNSPILYYIVELSEN 710
PQ + L +S AV++ W RP D + Y+
Sbjct: 802 VTIGYSGEDYPQAIPELEGIEILNSSAVLVKW-RPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 711 NSPWKVHLSN--VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
+S +H + V T V +SGL P +Y V A N GRG A PE P
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN--GRGSGPASEFTFSTPEGVP 918
Query: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQ-QRNITSPEV 827
P+ + ++N S++++WQPP HNGVL GY+L Y G+ Q N+ PE+
Sbjct: 919 -GHPEALHLECQSNTSLLLRWQPP--LSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPEL 975
Query: 828 NYCLVTDLIIWTQYEIQVAAYNGAGLG 854
+TDL +Y Q+ A G G
Sbjct: 976 RTHNLTDLSPHLRYRFQLQATTKEGPG 1002
Score = 68.6 bits (166), Expect = 7e-11
Identities = 90/422 (21%), Positives = 157/422 (37%), Gaps = 38/422 (9%)
Query: 274 SPFIHLSIARDVGTPETMAPTIVVPPG-NRSVVAGSSETTLECIASARPVEDLSVTWKRN 332
SP + + I + M P ++ R VV + + +L+C AS +P ++ W R+
Sbjct: 15 SPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKP--EVQFRWTRD 72
Query: 333 GVR----------ITSGLHSFGRRLTISNPTSAD--TGPYVCEAALPGSAFEPARATAFL 380
GV + HS +T +N A G Y C A+ + A +
Sbjct: 73 GVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFAS---NKLGTAMSHEIR 129
Query: 381 FIIE-PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA 439
+ E P + E + E E+V + C P ++ ++ + Q+ R +
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQ 189
Query: 440 SGGLRIQKLRPEDS-GIFQCFASNEGGEI------------QTHTYLDVTNIAPVFTQRP 486
+G L + D+ + C A G T++ +D T
Sbjct: 190 NGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSS 249
Query: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ 546
G +L C G P P I W R + + + V + LQ+ V +
Sbjct: 250 SHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN----HNKTLQLLKVGEE 305
Query: 547 DAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLR 606
D G Y C A N+ GS + +TV +H P+ H+ G TA L C P+ +
Sbjct: 306 DDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV- 364
Query: 607 YVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE 666
W+ + + + + + + G+L++S D CE + G A + V++
Sbjct: 365 -TWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ 423
Query: 667 LP 668
LP
Sbjct: 424 LP 425
Score = 57.8 bits (138), Expect = 1e-07
Identities = 73/329 (22%), Positives = 129/329 (39%), Gaps = 39/329 (11%)
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI---SRLQNPRYKVL 438
++EPP T + R+ + + + C+A G P +W +D + L Y+
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 439 ASGGLRI----QKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVF---TQRPVDTTV 491
SG I GI++CFASN+ G +H + AP + T +PV+ V
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE--V 148
Query: 492 TDGMTAILRCEVSGAPKP-AITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AG 549
+G + +L C + +P I W + R+ + ++G L A V D
Sbjct: 149 EEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERV---TMGQNGNLYFANVLTSDNHS 205
Query: 550 NYTCYA---------ANTEGSLNASATLTVWNRTSIVHPPEDH----VVIKGTTATLHCG 596
+Y C+A L AT ++ +R + P + V ++G L C
Sbjct: 206 DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECI 265
Query: 597 ATHDPRVSLRYVWKKDNVALTPSSTSRIVVEK-DGSLLISQTWSGDIGDYSCEIVSEGGN 655
A P +++ W + + P R+ + + +L + + D G+Y C + G+
Sbjct: 266 AEGFPTPTIK--WLRPS---GPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGS 320
Query: 656 DSRMARLEVIELP---HSPQNLLVSPNSS 681
+ V P H PQ+ L P +
Sbjct: 321 ARHAYYVTVEAAPYWLHKPQSHLYGPGET 349
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 258 bits (660), Expect = 3e-68
Identities = 243/969 (25%), Positives = 402/969 (41%), Gaps = 59/969 (6%)
Query: 124 LTCLAEGSWPLEFKWMRD--------DSELTTYSSEYKYIIP------SLQKLDAGFYRC 169
L C A G ++F+W RD + +T Y S + + + G YRC
Sbjct: 55 LKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114
Query: 170 VVRNRMGALLQRKSEVQVAYMGSF-MDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
N++G + + + + +T + V +G + +L P S ++ W
Sbjct: 115 FASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNS 174
Query: 229 GHKII---PSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGEN--KTSPFIHLSIAR 283
KI+ R+ + L TSD + Y+ + + P I L + +
Sbjct: 175 --KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEP-IDLRV-K 230
Query: 284 DVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPVEDLSVTWKRNGV-----RI 336
+ P ++ P + S V LECIA P ++ W R R+
Sbjct: 231 ATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTP--TIKWLRPSGPMPADRV 288
Query: 337 TSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRI 396
T H+ + L + D G Y C L ++ AR ++ + PY+ +P+S +
Sbjct: 289 TYQNHN--KTLQLLKVGEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHL 343
Query: 397 SAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIF 456
ET + CQ G P P + W + I + L + + G L + ++P D+ +
Sbjct: 344 YGP-GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 457 QCFASNEGGEIQTHTYLDVTNI-APVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKR 515
QC A N G + + Y+ V + A + T G TA L C+ GAP P++ W
Sbjct: 403 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 462
Query: 516 ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS 575
E+ + ++ RF +G L I + D G Y C AAN + ++ A L V + T
Sbjct: 463 ED---GTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ 519
Query: 576 IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
I P + KG+ T C A+ DP + W+ D L S +DG L+I
Sbjct: 520 ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIH 579
Query: 636 QTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVV-LSWVRPF 694
D G+YSC +E A+L V+ P L++S + + V +SW
Sbjct: 580 SLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAE 639
Query: 695 DGNSPILYYIVELSENN-SPWKVH-LSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRG 752
D N+PI Y +E + +P K + L V T T+ L+P Y FRV A+N+ G G
Sbjct: 640 DHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPG 698
Query: 753 QYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG 812
+ S + ++ PE P P ++ G ++++ W+P + N Y +++R G
Sbjct: 699 EPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQG 758
Query: 813 LPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAP 872
G +Q++ ++ P + +V++ + YEI+V A N G G + Y+ + P A
Sbjct: 759 TRGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI 815
Query: 873 PQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHH 932
P+ E +NS+ + W P + G +GY + W + + I D H V
Sbjct: 816 PELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKD-HVVVP 874
Query: 933 GHITN-----LKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTS 987
+ T+ L+ +++Y V F G GP S T E PG L +TS
Sbjct: 875 ANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTS 933
Query: 988 LKVSWQEPLEKNGIITGYQISWEVYGR-NDSRLTHTL-NSTTHEYKIQGLSSLTTYTIDV 1045
L + WQ PL NG++TGY +S+ +L+ L + + + LS Y +
Sbjct: 934 LLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQL 993
Query: 1046 AAVTAVGTG 1054
A T G G
Sbjct: 994 QATTKEGPG 1002
Score = 154 bits (389), Expect = 9e-37
Identities = 113/405 (27%), Positives = 185/405 (45%), Gaps = 21/405 (5%)
Query: 1070 PGAPSNLVISNI---SPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEEN 1126
PG LV+S++ + + + P D I ++ +E + + E+ W +L +
Sbjct: 612 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK-WYSLGKVPG 670
Query: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
+ L+ L+PY HY FR+ +N GP SP S + T +A P+ P V
Sbjct: 671 NQTSTTLK---LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 727
Query: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246
T++ + W PL +N V YR+++ + Q+VSD + ++
Sbjct: 728 TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 782
Query: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
YE+++QA N+ G GP +V G + E P A PE E ++S+ +L+ W V
Sbjct: 783 PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 1307 GLILGYKILF------RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
G + GY + + R + H+V +T S +L+GLR + Y L+V AF G
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR-LAS 1419
+G P++ T + PG P L TS+ + WQPP NG++ GY ++Y L
Sbjct: 903 SG-PASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 960
Query: 1420 SSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL 1464
+ +R TDL+P Y F+L A T++G GE +
Sbjct: 961 GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAI 1005
Score = 146 bits (368), Expect = 3e-34
Identities = 223/1033 (21%), Positives = 392/1033 (37%), Gaps = 112/1033 (10%)
Query: 219 PRPQVTWFREGHKIIPSNRIAITL-----ENQLVILATTTSDAGAYYVQAVNEKNGENKT 273
P Q W R+G P + +T+ I ++ A + Q + NK
Sbjct: 63 PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 120
Query: 274 SPFIHLSIARDV-GTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRN 332
+ I G P+ T+ + V E+ + E L + W +
Sbjct: 121 GTAMSHEIRLMAEGAPKWPKETV------KPVEVEEGESVVLPCNPPPSAEPLRIYWMNS 174
Query: 333 GV-------RITSGLHSFGRRLTISNPTSADT-GPYVCEAALPGSAF----EP----ARA 376
+ R+T G + L +N ++D Y+C A PG+ EP +A
Sbjct: 175 KILHIKQDERVTMGQNG---NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKA 231
Query: 377 TAFLFIIEPPY-FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDA--ISISRLQNP 433
T + +P F S + A + + + C A G P PT++W + + + R+
Sbjct: 232 TNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQ 291
Query: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
+ L++ K+ ED G ++C A N G + H Y AP + +P
Sbjct: 292 NHNKT----LQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 346
Query: 494 GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTC 553
G TA L C+V G P+P +TW R N I + ++ + + G L ++ V D C
Sbjct: 347 GETARLDCQVQGRPQPEVTW-RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQC 404
Query: 554 YAANTEGSLNASATLTVWNRTSIVHPPED--HVVIKGTTATLHCGATHDPRVSLRYVWKK 611
A N G L A+A + V + + ++ ++ ++G+TA L C A P S++++
Sbjct: 405 EARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL--- 461
Query: 612 DNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV---IELP 668
D T R +G+L I + D G Y C ++ N + MA L+V ++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 669 HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGV 728
P++ + S V + FD P L + + W+ G ++ +
Sbjct: 522 QGPRSTIEKKGSR----VTFTCQASFD---PSL-------QPSITWR----GDGRDLQEL 563
Query: 729 TVSGLTPARTYQFRVCAVNEVGRGQYSA---------ETSRLMLPEEPPSAPPKNIVASG 779
S + + +++ +G YS E+ +L P P+ +++
Sbjct: 564 GDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623
Query: 780 R--TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII 837
T + V W P + HN + Y + + + E P L
Sbjct: 624 HLLTQSQVRVSWSPAED--HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 681
Query: 838 WTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQ 896
+ Y +V A N G G S + T T + P P +V+ E +T + W P
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWM 741
Query: 897 FINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGD 956
N Y++ W I D V ++N F Y V + G
Sbjct: 742 DWNAPQVQYRV-QWRPQGTRGPWQEQIVSDPFLV----VSNTSTFVPYEIKVQAVNSQGK 796
Query: 957 GPPSTPQLVWTQEDKPGAVGHLSFTEILDTS-LKVSWQ--EPLEKNGIITGYQISWEVYG 1013
GP + ++ ED P A+ L EIL++S + V W+ + + G + GY ++ Y
Sbjct: 797 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT---YW 853
Query: 1014 RNDSRLTHT----------LNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
R S+ H+ + + T + GL ++Y ++V A G+G + T S+
Sbjct: 854 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST 913
Query: 1064 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYE 1123
P +PG P L + S S L+++P ++ +++ G + + L
Sbjct: 914 --PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQ---LSF 968
Query: 1124 EENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVR 1183
+P+ + + +L+P+ YRF+++ GP L D S
Sbjct: 969 NLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA--- 1025
Query: 1184 TASETSLRLRWVP 1196
TA E + WVP
Sbjct: 1026 TAGENYSVVSWVP 1038
Score = 132 bits (332), Expect = 4e-30
Identities = 133/576 (23%), Positives = 237/576 (41%), Gaps = 50/576 (8%)
Query: 1477 PAP-PRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV--RELPRGEWQTYSSSISH 1533
P P PR +L +T +R+ W P D +PI + ++ +E+ +W + +
Sbjct: 612 PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 671
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+ + + +L P+ Y R+ A N G + S +E V T + P + P V + T+
Sbjct: 672 QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 729
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
+++I W+P R N YR+ +R GT E F V
Sbjct: 730 NMVITWKPLRWMDWNAPQVQYRVQWRP------QGTRGPW--------QEQIVSDPFLVV 775
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+++ST + YE+ + A N G+ P + GE P P+ + L
Sbjct: 776 SNTST-----------FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL 824
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKV----LFLPEPV--VRLKN 1767
+S + V W P G+++GY + YW SQ + K + + +P V L
Sbjct: 825 NSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSG 884
Query: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
L ++ Y + + AFN G GP S+ T + PG P L ++T+L + W P +
Sbjct: 885 LRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLS 943
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYG 1887
NG+L GY + Y PL +G ++ +R R + DL+ + Y F++QA T G
Sbjct: 944 HNGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQA-TTKEG 1000
Query: 1888 PELQANITAGPAEGSPGSP--RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEG 1945
P +A + G G ++ T + + W + +A ++G
Sbjct: 1001 PG-EAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKG 1059
Query: 1946 LWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP-- 2003
+ + + + +SYT L+ YE + E + T + +V P
Sbjct: 1060 GASLSPQYVSYNQSSYTQW--DLQPDTDYEIHL--FKERMFRHQMAVKTNGTGRVRLPPA 1115
Query: 2004 -FYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY 2038
F E WF+ ++ L++++L++ + + KY
Sbjct: 1116 GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKY 1151
Score = 107 bits (267), Expect = 1e-22
Identities = 194/807 (24%), Positives = 302/807 (37%), Gaps = 106/807 (13%)
Query: 106 FKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKL--- 162
F T + L+G LVL C+AEG KW+R + Y+ +LQ L
Sbjct: 244 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVG 303
Query: 163 --DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR 220
D G YRC+ N +G+ + V V ++ Q G A L+ + P+
Sbjct: 304 EEDDGEYRCLAENSLGS-ARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD-CQVQGRPQ 361
Query: 221 PQVTWFREGHKIIPSNRIAITLE-----NQLVILATTTSDAGAYYVQAVNEKNGENKTSP 275
P+VTW G IP +A + L++ SD +A N ++G +
Sbjct: 362 PEVTWRING---IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN-RHGLLLANA 417
Query: 276 FIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETT-LECIASARPVEDLSVTW-KRNG 333
+I++ P ++ N++ +A T L C A PV SV W +G
Sbjct: 418 YIYV----------VQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP--SVQWLDEDG 465
Query: 334 VRITSGLHSF---GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTA 390
+ F L I + + DTG Y C AA + A L + + T
Sbjct: 466 TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAA---NDQNNVTIMANLKVKDATQITQ 522
Query: 391 EPESRISAEVEETVDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKL 448
P S I + V CQA P P++ W D + L + + G L I L
Sbjct: 523 GPRSTIEKK-GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSL 581
Query: 449 RPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPK 508
D G + C AS E +++ L V V + PV V + + + +V +
Sbjct: 582 DYSDQGNYSCVASTELDVVESRAQLLV-----VGSPGPVPRLVLSDLHLLTQSQVRVSWS 636
Query: 509 PAITWKRENHILASGSVRIPRFMLLESGGLQIAP----VFIQDAGNYTCYAANTEGSLNA 564
PA E+H + I ++ +E ++AP + GN T ++
Sbjct: 637 PA-----EDH-----NAPIEKYD-IEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHY 685
Query: 565 SATLTVWNR--------------TSIVHPPEDHVVIKG----------TTATLHCGATHD 600
+ +T N+ T P ++ V +KG T L +
Sbjct: 686 TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNA 745
Query: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660
P+V R W+ T +V D L++S T + + + V+ G
Sbjct: 746 PQVQYRVQWRPQG---TRGPWQEQIV-SDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQ 801
Query: 661 RLEVIELPHSPQNL--LVSPNSSHSHAVVLSWVRPFD--------GNSPILYYIVELSEN 710
PQ + L +S AV++ W RP D + Y+
Sbjct: 802 VTIGYSGEDYPQAIPELEGIEILNSSAVLVKW-RPVDLAQVKGHLRGYNVTYWREGSQRK 860
Query: 711 NSPWKVHLSN--VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
+S +H + V T V +SGL P +Y V A N GRG A PE P
Sbjct: 861 HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN--GRGSGPASEFTFSTPEGVP 918
Query: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQ-QRNITSPEV 827
P+ + ++N S++++WQPP HNGVL GY+L Y G+ Q N+ PE+
Sbjct: 919 -GHPEALHLECQSNTSLLLRWQPP--LSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPEL 975
Query: 828 NYCLVTDLIIWTQYEIQVAAYNGAGLG 854
+TDL +Y Q+ A G G
Sbjct: 976 RTHNLTDLSPHLRYRFQLQATTKEGPG 1002
Score = 68.6 bits (166), Expect = 7e-11
Identities = 90/422 (21%), Positives = 157/422 (37%), Gaps = 38/422 (9%)
Query: 274 SPFIHLSIARDVGTPETMAPTIVVPPG-NRSVVAGSSETTLECIASARPVEDLSVTWKRN 332
SP + + I + M P ++ R VV + + +L+C AS +P ++ W R+
Sbjct: 15 SPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKP--EVQFRWTRD 72
Query: 333 GVR----------ITSGLHSFGRRLTISNPTSAD--TGPYVCEAALPGSAFEPARATAFL 380
GV + HS +T +N A G Y C A+ + A +
Sbjct: 73 GVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFAS---NKLGTAMSHEIR 129
Query: 381 FIIE-PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA 439
+ E P + E + E E+V + C P ++ ++ + Q+ R +
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQ 189
Query: 440 SGGLRIQKLRPEDS-GIFQCFASNEGGEI------------QTHTYLDVTNIAPVFTQRP 486
+G L + D+ + C A G T++ +D T
Sbjct: 190 NGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSS 249
Query: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ 546
G +L C G P P I W R + + + V + LQ+ V +
Sbjct: 250 SHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN----HNKTLQLLKVGEE 305
Query: 547 DAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLR 606
D G Y C A N+ GS + +TV +H P+ H+ G TA L C P+ +
Sbjct: 306 DDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV- 364
Query: 607 YVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE 666
W+ + + + + + + G+L++S D CE + G A + V++
Sbjct: 365 -TWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ 423
Query: 667 LP 668
LP
Sbjct: 424 LP 425
Score = 57.8 bits (138), Expect = 1e-07
Identities = 73/329 (22%), Positives = 129/329 (39%), Gaps = 39/329 (11%)
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI---SRLQNPRYKVL 438
++EPP T + R+ + + + C+A G P +W +D + L Y+
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 439 ASGGLRI----QKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVF---TQRPVDTTV 491
SG I GI++CFASN+ G +H + AP + T +PV+ V
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE--V 148
Query: 492 TDGMTAILRCEVSGAPKP-AITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AG 549
+G + +L C + +P I W + R+ + ++G L A V D
Sbjct: 149 EEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERV---TMGQNGNLYFANVLTSDNHS 205
Query: 550 NYTCYA---------ANTEGSLNASATLTVWNRTSIVHPPEDH----VVIKGTTATLHCG 596
+Y C+A L AT ++ +R + P + V ++G L C
Sbjct: 206 DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECI 265
Query: 597 ATHDPRVSLRYVWKKDNVALTPSSTSRIVVEK-DGSLLISQTWSGDIGDYSCEIVSEGGN 655
A P +++ W + + P R+ + + +L + + D G+Y C + G+
Sbjct: 266 AEGFPTPTIK--WLRPS---GPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGS 320
Query: 656 DSRMARLEVIELP---HSPQNLLVSPNSS 681
+ V P H PQ+ L P +
Sbjct: 321 ARHAYYVTVEAAPYWLHKPQSHLYGPGET 349
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 256 bits (655), Expect = 1e-67
Identities = 241/951 (25%), Positives = 386/951 (40%), Gaps = 66/951 (6%)
Query: 165 GFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQ-GRAAILNLLPITSYPRPQV 223
G Y+C RN+ G L + +QV+ + + V Q G L P P P +
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVI 167
Query: 224 TWFREGHKIIPSNRIAITLEN-----QLVILATTTSD----AGAYYVQAVNEKNG----- 269
W + I ++ N V+L +D A ++ + +KN
Sbjct: 168 FWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
Query: 270 -----ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPV 322
N +S H + G E P+ + P G S +V + LECIAS P
Sbjct: 228 LTNHPYNDSSLRNHPDMYSARGVAER-TPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 286
Query: 323 EDLSVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
D++ W + G + S +F + L I+N + D+G Y C L + R T
Sbjct: 287 PDIA--WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC---LASNKMGSIRHTIS 341
Query: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI-SRLQNPRYKVL 438
+ + PY+ EP++ I A E+ + C+A G P PT+QW + + S NP +V
Sbjct: 342 VRVKAAPYWLDEPKNLILAPGEDG-RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV- 399
Query: 439 ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTA 497
A + + + ++QC SNE G + + ++ V ++ P + + R V
Sbjct: 400 AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 459
Query: 498 ILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
L C G+P P + W + ++ + + E+G L+I + +D G YTC A N
Sbjct: 460 RLDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
Query: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALT 617
G L V + T I PED V +GTT L C HDP + L W KD+
Sbjct: 517 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD---E 573
Query: 618 PSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
P + ++D SL I D G Y+C +E D A L V+ +P N L +
Sbjct: 574 PLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAA 633
Query: 678 PNSSH-------------SHAVVLSWVRPFDGNSPILYYIVELSENN-SPWKVHLSNVGP 723
+V L+W+ NSPI Y+V+ E+ P H + P
Sbjct: 634 LPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP 693
Query: 724 EMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQ 783
V L+P YQFRV A+NEVG S + R PP + P ++ G
Sbjct: 694 GSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKN 753
Query: 784 SIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEI 843
++ + W P T G YI+++R + N+T Y +V ++ YEI
Sbjct: 754 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAW--NNVTVWGSRY-VVGQTPVYVPYEI 810
Query: 844 QVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQ 903
+V A N G G +V Y+ + P A P V+ +NST I WN + G +
Sbjct: 811 RVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLR 870
Query: 904 GYKLLAWPADAPEA---VTVVTIAPDFHGVH-HGHITNLKKFTAYFTSVLCFTTPGDGPP 959
Y+ W + V+ F G G ++ L ++ Y ++ GDGP
Sbjct: 871 EYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPR 930
Query: 960 STPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG--RNDS 1017
S + T E P A + ++ + W P NGI+ GY + + + +
Sbjct: 931 SETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGK 990
Query: 1018 RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPD 1068
++ + ++ +Q ++ Y ++A T VG+G + T S PP+
Sbjct: 991 QIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG--EAVTEESPAPPN 1039
Score = 132 bits (331), Expect = 5e-30
Identities = 108/427 (25%), Positives = 188/427 (44%), Gaps = 25/427 (5%)
Query: 1063 SGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLY 1122
+ +P P P +L +++++ RS L + PG + I+ ++V+ + D+ + +
Sbjct: 632 AALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEE----DQFQPGVWH 687
Query: 1123 EEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV 1182
+ P + + L+PY +Y+FR+ +N VG S S S +T APP+ P V
Sbjct: 688 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKG 747
Query: 1183 RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEEL 1242
+ ++ + W P+ + G ++ Y +K+ R + + + V + + +
Sbjct: 748 EGTRKNNMEITWTPMNATSAFG--PNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQT 802
Query: 1243 EEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPE 1302
++ YE+++QA N G GP E V G + E P AAP V ++ST I L W V
Sbjct: 803 PVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYS 862
Query: 1303 QDQNGLILGYKILF-RAKDL-----DPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAF 1356
G + Y+ + R L + R +++ L + Y+L+++
Sbjct: 863 DTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVV 922
Query: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416
G+G P + T + P P R + L ++ + W PE PNGI++GY + Y
Sbjct: 923 NGRGDG-PRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYV 981
Query: 1417 LASSSPHTFTTVE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRE 1475
+ + VE +FT P S Y F LSA+T+ G GE + E
Sbjct: 982 AFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAV--------TEE 1033
Query: 1476 RPAPPRE 1482
PAPP E
Sbjct: 1034 SPAPPNE 1040
Score = 126 bits (317), Expect = 2e-28
Identities = 112/437 (25%), Positives = 177/437 (40%), Gaps = 40/437 (9%)
Query: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRE--LPRGEWQTYSSSISH 1533
RP PR+L + ++ RS+RL W+PG SPI + +Q E G W +S
Sbjct: 638 RPDRPRDLEL--TDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGS 695
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
+A + RL P+ +Y+ R+ A N++G S S +E T P PG V +
Sbjct: 696 VNSAVL--RLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKN 753
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
++ I W P S G Y + +R E +T S V
Sbjct: 754 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNN--------------VTVWGSRYVV 799
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
+ Y YE+ + A N G+ P V + GE P AP V+V +
Sbjct: 800 GQTPV-----------YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM 848
Query: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVRLKNLTS- 1770
++ + + W+ ++ G ++ Y+ YYW S +N K P RL+ + S
Sbjct: 849 NSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSR 908
Query: 1771 ---HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
++ Y + + N GDGP+S+ ++ T + P AP + T+N+ W P
Sbjct: 909 LFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEH 968
Query: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITY 1886
NGI+ GY + Y + V K + N Q V+ Y F + ART +
Sbjct: 969 PNGIMIGYTLKYVAFNGTK-VGKQIVENFSPN-QTKFTVQRTDPVSRYRFTLSARTQVGS 1026
Query: 1887 GPELQANITAGPAEGSP 1903
G + A P E +P
Sbjct: 1027 GEAVTEESPAPPNEATP 1043
Score = 111 bits (277), Expect = 9e-24
Identities = 229/1085 (21%), Positives = 405/1085 (37%), Gaps = 162/1085 (14%)
Query: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASG 441
+ +PP T + + + + I C+A G P P+ W +++ + ++PR +
Sbjct: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 442 GLRIQKL----RPED-SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
G + RPE+ G +QCFA N+ G ++ + +P++ + +D V +G
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
Query: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AGNYTC 553
L+C G P P I W + + R+ + +G L + V +QD +Y+C
Sbjct: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG---HNGDLYFSNVMLQDMQTDYSC 207
Query: 554 YA----ANTEGSLNASATLTV-----WNRTSIVHPPE----------------------D 582
A +T N TL V +N +S+ + P+
Sbjct: 208 NARFHFTHTIQQKN-PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 583 HVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI 642
+V++G L C A+ P + + K ++ PS ++ + +L I+ D
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKF-ENFNKALRITNVSEEDS 322
Query: 643 GDYSCEIVSEGGNDSRMARLEVIELPH---SPQNLLVSPNSSHSHAVVLSWVRPFDGN-S 698
G+Y C ++ G+ + V P+ P+NL+++P V +GN
Sbjct: 323 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG------RLVCRANGNPK 376
Query: 699 PILYYIVELSENNSPWKVHLSNVGPEMTGVTV----SGLTPARTYQFRVCAVNEVGRGQY 754
P + ++V N P + N E+ G T+ + ++ YQ NE G
Sbjct: 377 PTVQWMV----NGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS--NEHGYLLA 430
Query: 755 SAETSRLMLPEEPPSAPPKN----IVASGRTNQSIMVQWQPPP------ETEHNGVLRGY 804
+A S L +P P P+N ++ RT P P + + + G
Sbjct: 431 NAFVSVLDVP--PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 488
Query: 805 ILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYT 864
Y L E + + C+ T+++ + ++++ + ++ +
Sbjct: 489 YHVYENGSL--EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT--RIYRMPEDQVA 544
Query: 865 LQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIA 924
+G V+ + T+ +L + P N + + +++T+ +A
Sbjct: 545 RRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK----------EDDSLTIFGVA 594
Query: 925 PDFHGVHH-GHITNLKKFTA--YFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT 981
G + T L + A Y T + TP T +L + +P L T
Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLADQATP------TNRLAALPKGRPDRPRDLELT 648
Query: 982 EILDTSLKVSWQEPLEKNGIITGYQISWEV------YGRNDSRLTHTLNSTTHEYKIQGL 1035
++ + S++++W N IT Y + +E + S+ ++NS + L
Sbjct: 649 DLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSA-----VLRL 703
Query: 1036 SSLTTYTIDVAAVTAVGT---GLVTSSTISSGVPPDL-------PGAPSNLVISNISPRS 1085
S Y V A+ VG+ L + +SG PP+ G N + +P +
Sbjct: 704 SPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMN 763
Query: 1086 ATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYR 1145
AT F P I +W A + W + Y P Y Y
Sbjct: 764 ATSAFGPNL---RYIVKWRRRETREAWNNVTVWGSRYVVGQTP-----------VYVPYE 809
Query: 1146 FRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGN 1205
R++ N G P P S + + + P APT V VR + T++ L+W + G
Sbjct: 810 IRVQAENDFGKGP-EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQ 868
Query: 1206 PESVGYRIKYWRSD--------LQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNA 1257
YR YWR Q A DRL + L + Y+L+M N
Sbjct: 869 LRE--YRAYYWRESSLLKNLWVSQKRQQASFPGDRLRG--VVSRLFPYSNYKLEMVVVNG 924
Query: 1258 VGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR 1317
G GP SE T E VPS AP + I L W PE NG+++GY + +
Sbjct: 925 RGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWDH-PEH-PNGIMIGYTLKYV 981
Query: 1318 AKDLDPEPRSHIVRGNHTQSALLAGLRKFV-LYELQVLAFTRIGNGVPSTPLILERTKDD 1376
A + + + + Q+ V Y + A T++G+G E ++
Sbjct: 982 AFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG--------EAVTEE 1033
Query: 1377 APGPP 1381
+P PP
Sbjct: 1034 SPAPP 1038
Score = 74.7 bits (182), Expect = 9e-13
Identities = 96/423 (22%), Positives = 164/423 (38%), Gaps = 47/423 (11%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-----HTFTTVEVGA 1432
P P L ++ SVR+ W P + N I Y + + P H+ V +
Sbjct: 639 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS 698
Query: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL--VPQAEV 1490
V + L+P Y FR+ A G P ++ + R APP V
Sbjct: 699 AVLR-----LSPYVNYQFRVIAINEVGSSHP---SLPSERYRTSGAPPESNPGDVKGEGT 750
Query: 1491 TARSLRLQWVP--GSDGASP-IRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFT 1547
++ + W P + P +RY R R W ++++ + VV + +
Sbjct: 751 RKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW----NNVTVWGSRYVVGQTPVYV 806
Query: 1548 SYKLRLKATNDIGDSDFSSETEAVTTL--QDVPGEPPGSVSATPHTTSSVLIQWQPPRDE 1605
Y++R++A ND G E E+V +D P P V ++++ +QW +
Sbjct: 807 PYEIRVQAENDFGKGP---EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD 863
Query: 1606 SLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELT 1665
++ G L+ YR YY E+ LKN ++ Q+SF ++
Sbjct: 864 TVQGQLREYRAYY---------WRESSLLKN--LWVSQKRQQASFPGDRLRGV-----VS 907
Query: 1666 HLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPP 1725
L Y Y++ M N G+ P S E E P+ AP+ +V + + WD
Sbjct: 908 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWD-- 964
Query: 1726 PPESQNGNIQGYKIYYWEADSQNETEKMKVLFLP-EPVVRLKNLTSHTKYLVSISAFNAA 1784
PE NG + GY + Y + +++ F P + ++ ++Y ++SA
Sbjct: 965 HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQV 1024
Query: 1785 GDG 1787
G G
Sbjct: 1025 GSG 1027
Score = 62.4 bits (150), Expect = 5e-09
Identities = 103/497 (20%), Positives = 187/497 (37%), Gaps = 50/497 (10%)
Query: 1562 SDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYREL 1621
+D ++ T + L + P + T SV + W P ++ N + Y + + E
Sbjct: 622 ADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEED 679
Query: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
+++ G + H++ +VNS+ + L Y Y+ + A N
Sbjct: 680 QFQPGVWHD----------HSKYPG-----SVNSA-------VLRLSPYVNYQFRVIAIN 717
Query: 1682 IIGESPASAPVEVFVGEAAPAMA-PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY 1740
+G S S P E + AP + P +V+ + +E+TW P S G Y I
Sbjct: 718 EVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY-IV 776
Query: 1741 YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA 1800
W E ++ VV + + Y + + A N G GP+ + G + +
Sbjct: 777 KWRRRETREAWNNVTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGED 834
Query: 1801 AP-GAPSFLAFSEITSTTLNVSWGEPAA--ANGILQGYRVVY----EPLAPVQGVSKVVT 1853
P AP+ + + ST +++ W + G L+ YR Y L + K
Sbjct: 835 YPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ 894
Query: 1854 VEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTK 1913
G+ R + R V GP + P EG P +PR V +
Sbjct: 895 ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFRVRQ 953
Query: 1914 SASE-LTLQWTEGHSGDTPTTGYVIE-ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQG 1971
E + L+W + GY ++ + + V++ + T +T+ +
Sbjct: 954 PNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQ--RTDPV 1011
Query: 1972 VTYEFRVVAVNEAGYGE--------PSNPSTAVSAQV--EAPFYEEWWFLLVMALSSLIV 2021
Y F + A + G GE P N +T +A +A + WF+ +M +L+V
Sbjct: 1012 SRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLV 1071
Query: 2022 ILLVVFALVLHGQNKKY 2038
++L++ + + KY
Sbjct: 1072 LILLIVCFIKRSRGGKY 1088
Score = 55.8 bits (133), Expect = 4e-07
Identities = 83/374 (22%), Positives = 140/374 (37%), Gaps = 32/374 (8%)
Query: 114 QIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI-----IPSLQKLDAGFYR 168
Q+ L G L+L C+A G + W + +L + ++++ I ++ + D+G Y
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 326
Query: 169 CVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
C+ N+MG+ ++ V+V ++D + ++ G L + P+P V W
Sbjct: 327 CLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRL-VCRANGNPKPTVQWMVN 384
Query: 229 GHKI--IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVG 286
G + P N + ++ T S Y NE +G + F+ +
Sbjct: 385 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE-HGYLLANAFVSVL------ 437
Query: 287 TPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF--G 344
+ P ++ P V + T L+C P+ L G + G +
Sbjct: 438 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 494
Query: 345 RRLTISNPTSADTGPYVCEAA-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403
L I D G Y C A + G A R L + +P PE ++ A T
Sbjct: 495 GSLEIKMIRKEDQGIYTCVATNILGKAENQVR----LEVKDPTRIYRMPEDQV-ARRGTT 549
Query: 404 VDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFAS 461
V + C+ P T+ W KD + + N K L I + D G + C AS
Sbjct: 550 VQLECRVKHDPSLKLTVSWLKDDEPL-YIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
Query: 462 NEGGEIQTHTYLDV 475
E + YL V
Sbjct: 607 TELDQDLAKAYLTV 620
Score = 35.4 bits (80), Expect = 0.63
Identities = 45/193 (23%), Positives = 72/193 (37%), Gaps = 16/193 (8%)
Query: 464 GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASG 523
GG I+ +D+T + Q D V ++ CE G P P+ W R +
Sbjct: 22 GGAIEIP--MDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF--N 77
Query: 524 SVRIPRFMLLESGGLQIAPVFI-----QDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
+ PR + G + + G Y C+A N G+ S + + S +
Sbjct: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLW 136
Query: 579 PPE--DHVVI-KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
P E D VV+ +G TL C P + ++ + + R+ +G L S
Sbjct: 137 PKENLDPVVVQEGAPLTLQCNP--PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
Query: 636 QTWSGDI-GDYSC 647
D+ DYSC
Sbjct: 195 NVMLQDMQTDYSC 207
Score = 34.7 bits (78), Expect = 1.1
Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 4/110 (3%)
Query: 667 LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSP--WKVHLSNVGPE 724
+P +P+ V + + L W P N ++ Y ++ N K + N P
Sbjct: 942 VPSAPRRFRV--RQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPN 999
Query: 725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKN 774
T TV P Y+F + A +VG G+ E S E P+A N
Sbjct: 1000 QTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1049
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 253 bits (646), Expect = 1e-66
Identities = 292/1119 (26%), Positives = 467/1119 (41%), Gaps = 98/1119 (8%)
Query: 384 EPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDA--ISISRLQNPRYKVLASG 441
EPP F EP+ +I CQA G P P + W K ++ R + + A
Sbjct: 31 EPPRFIKEPKDQIGVS-GGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGA 89
Query: 442 GLRIQKLR-PEDSGIFQCFASNEGGEIQTHTYLDV------TNIAPVFTQRPVDTTVTDG 494
LRIQ LR P D +++C A N GEI H L V + P P V
Sbjct: 90 VLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERT 149
Query: 495 MTAILRCEVSGAPKPAITWKRE----NHILASGSVRIPRFMLLES----GGLQIAPVFIQ 546
TA + C SG P P ITW ++ + ++G ++ R ES G LQI
Sbjct: 150 RTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEET 209
Query: 547 DAGNYTCYAANTEG-SLNASATLTVWNRTSI--VHP-----PEDHVVIKGTTATLHCGAT 598
D G Y C A N+ G ++ A L V + V P P H ++ G + C A
Sbjct: 210 DQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV 269
Query: 599 HDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSR 658
P ++ W + LTP + G ++ T D +Y+C +S G
Sbjct: 270 GSPMPYVK--WMQGAEDLTPEDDMPV-----GRNVLELTDVKDSANYTCVAMSSLGVIEA 322
Query: 659 MARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGN-SPILYYIVELSENNSPWKVH 717
+A++ V LP +P +V+ N++ S + ++W GN P+ YY++E +
Sbjct: 323 VAQITVKSLPKAPGTPMVTENTATS--ITITW---DSGNPDPVSYYVIEYKSKSQDGPYQ 377
Query: 718 LSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVA 777
+ T ++ GL+P Y+ V AVN +G+G S E+ E+ P++ P+N+ A
Sbjct: 378 IKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPS-ESVVTRTGEQAPASAPRNVQA 435
Query: 778 SGRTNQSIMVQWQPPPETEHNGVLRGYILRYRL--AGLPGEYQQRNITSPEVNYCLVTDL 835
+ +++VQW+ P E NG++RGY + Y + G +Q+ N+ + V L
Sbjct: 436 RMLSATTMIVQWEEP--VEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT--TVGSL 491
Query: 836 IIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQ 895
+ Y ++V A+ G G S + T QGVP P N++ EA + T+I W+PP Q
Sbjct: 492 LEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQ 550
Query: 896 QFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPG 955
+ I Y+LL D V F + +LK T Y + + G
Sbjct: 551 ESI----IKYELLFREGDHGREV-----GRTFDPTTSYVVEDLKPNTEYAFRLAARSPQG 601
Query: 956 DGPPSTPQLVWTQEDKPGAVGH-LSFTEILDTSLKVSWQEPLEK--NGIITGYQISWEVY 1012
G + T + KP A + + T++ VSW+ P + NG + GY + +
Sbjct: 602 LGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661
Query: 1013 GRND--SRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP 1070
G D + + + TT + ++ L T Y I A T VG G SS + D+P
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG-PESSPVVVRTDEDVP 720
Query: 1071 GAPSNLVISN-ISPRSATLQFRPGYDGKT-------SISRWIVEGQVGAIGDEEEWVTLY 1122
AP V + ++ + + +R G+ + +EG + V L
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 1123 EEENEPD---AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTS 1179
+ + E D + I NL P T Y + + G S +V+ T A + +
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARS-KPKVVVTKGAV--LGRPT 837
Query: 1180 VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTI 1239
++V+ E SL RW P + + +GYR+++ R D S+ +A + E +T
Sbjct: 838 LSVQQTPEGSLLARWEPPAGT---AEDQVLGYRLQFGRED--STPLATLEFPPSEDRYTA 892
Query: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEA-VSSTQILLTWT 1298
+ + Y ++ A + G G + V E P P+ + A S+ +LL W
Sbjct: 893 SGVHKGATYVFRLAARSRGGLGEEAAEVLS-IPEDTPRGHPQILEAAGNASAGTVLLRWL 951
Query: 1299 SVPEQDQNGLILGYKILFR-AKDLDPEPRSHIVRGNH--TQSAL-LAGLRKFVLYELQVL 1354
++NG I+ Y + R A L P + + ++AL L GL+ Y+LQV
Sbjct: 952 PPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVR 1011
Query: 1355 AFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIA 1414
A TR G G P +P + RT P + TSV + W+ P+ N Y+I
Sbjct: 1012 AHTRRGPG-PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNS-PTPYKIQ 1069
Query: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453
Y T++V + T L P + Y F L+
Sbjct: 1070 Y--------NGLTLDVDGRTTKKLITHLKPHTFYNFVLT 1100
Score = 199 bits (506), Expect = 3e-50
Identities = 273/1084 (25%), Positives = 429/1084 (39%), Gaps = 158/1084 (14%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLENQL-----VILATTTSDAGAYYVQAVNEKNGE 270
T P+P+VTW ++G K+ I + + T D Y A +N
Sbjct: 57 TGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVA---QNSV 113
Query: 271 NKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWK 330
+ + L++ R+ P P I + P VV + T+ C AS P D +TW
Sbjct: 114 GEITVHAKLTVLREDQLPSGF-PNIDMGP-QLKVVERTRTATMLCAASGNP--DPEITWF 169
Query: 331 RNGVRITSGLHSFGR----------------RLTISNPTSADTGPYVCEAALPGSAFEPA 374
++ + + S GR L I + D G Y C A SA
Sbjct: 170 KDFLPVDPSA-SNGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVAT--NSAGVRY 226
Query: 375 RATAFLFIIE-------PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI 427
+ A L++ E P F+ P S V+I C A+G P+P ++W + A +
Sbjct: 227 SSPANLYVRELREVRRVAPRFSILPMSH-EIMPGGNVNITCVAVGSPMPYVKWMQGAEDL 285
Query: 428 SRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPV 487
+ + + G ++ +DS + C A + G I+ + V ++ P P+
Sbjct: 286 TPEDD-----MPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL-PKAPGTPM 339
Query: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
T T T+I SG P P + +++ Q P I++
Sbjct: 340 VTENT--ATSITITWDSGNPDP-----------------VSYYVIEYKSKSQDGPYQIKE 380
Query: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVH-----PPEDHVV----------------- 585
T Y+ G L+ ++ +W S V+ PP + VV
Sbjct: 381 DITTTRYSI---GGLSPNSEYEIW--VSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQA 435
Query: 586 --IKGTTATLHCGATHDPRVSLRYV--------------WKKDNVALTPSSTSRIVVEKD 629
+ TT + +P +R W+K NV + +T
Sbjct: 436 RMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTV------- 488
Query: 630 GSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS 689
GSLL +T++ + ++ V +G + +P P NL S S + LS
Sbjct: 489 GSLLEDETYTVRVLAFTS--VGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS--ITLS 544
Query: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749
W P I+ Y + E + +V T V L P Y FR+ A +
Sbjct: 545 WSPP--RQESIIKYELLFREGDHGREV--GRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
Query: 750 GRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYR 809
G G ++ + L + PSAPP+++ + +I+V W+PPP HNG L GY +RYR
Sbjct: 601 GLGAFTPVVRQRTL-QSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659
Query: 810 -LAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGV 868
L E ++ N P L+ L WTQY I A+ G G S V T + V
Sbjct: 660 PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV 719
Query: 869 PTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGY-----KLLAWPADAPEAVTVVTI 923
P+APP+ V+ EA+N+T I+ LW P +G +GY ++ A P + V +
Sbjct: 720 PSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML 779
Query: 924 A-----PDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGH- 977
A D + ITNL+ TAY +V +T GDG S P++V T K +G
Sbjct: 780 ADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVT---KGAVLGRP 836
Query: 978 -LSFTEILDTSLKVSWQEPL-EKNGIITGYQISWEVYGRNDSRLTHTLNSTTHE--YKIQ 1033
LS + + SL W+ P + GY++ +GR DS TL E Y
Sbjct: 837 TLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ---FGREDSTPLATLEFPPSEDRYTAS 893
Query: 1034 GLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP-GAPSNL-VISNISPRSATLQFR 1091
G+ TY +AA + G G + +S +P D P G P L N S + L++
Sbjct: 894 GVHKGATYVFRLAARSRGGLGEEAAEVLS--IPEDTPRGHPQILEAAGNASAGTVLLRWL 951
Query: 1092 PGYDGKTS---ISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQ-MLEIPNLTPYTHYRFR 1147
P + + + + + GA+G E T EP A+ L + L P T Y +
Sbjct: 952 PPVPAERNGAIVKYTVAVREAGALGPARE--TELPAAAEPGAENALTLQGLKPDTAYDLQ 1009
Query: 1148 MKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPE 1207
++ GP P+SP R L+ V+P + V+ +TS+ L W PD+ + P
Sbjct: 1010 VRAHTRRGPGPFSPPVRYRTFLR--DQVSPKNFKVKMIMKTSVLLSW-EFPDNYNSPTPY 1066
Query: 1208 SVGY 1211
+ Y
Sbjct: 1067 KIQY 1070
Score = 193 bits (490), Expect = 2e-48
Identities = 270/1140 (23%), Positives = 445/1140 (39%), Gaps = 139/1140 (12%)
Query: 480 PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQ 539
P F + P D G A C+ +G PKP +TW ++ + S F L+
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 540 IAPVFI-QDAGNYTCYAANTEGSLNASATLTVWNRT-------SIVHPPEDHVVIKGTTA 591
I P+ +D Y C A N+ G + A LTV +I P+ VV + TA
Sbjct: 93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 592 TLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKD----------GSLLISQTWSGD 641
T+ C A+ +P + W KD + + PS+++ + + G+L I + D
Sbjct: 153 TMLCAASGNPDPEI--TWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETD 210
Query: 642 IGDYSCEIVSEGG-NDSRMARLEVIELPHSPQNLLVSPNSS---HSHAVVLSWVRPFDGN 697
G Y C + G S A L V EL + V+P S SH ++ GN
Sbjct: 211 QGKYECVATNSAGVRYSSPANLYVRELREVRR---VAPRFSILPMSHEIMPG------GN 261
Query: 698 SPILYYIVELSENNSPWKVHLSNVGPE---MTGVTVSGLTPARTYQFRVC-AVNEVGRGQ 753
I V W ++ PE G V LT + C A++ +G +
Sbjct: 262 VNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIE 321
Query: 754 YSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGL 813
A+ + LP+ P + + + T SI + W ++ + + Y++ Y+
Sbjct: 322 AVAQITVKSLPKAPGTP-----MVTENTATSITITW----DSGNPDPVSYYVIEYKSKSQ 372
Query: 814 PGEYQ-QRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAP 872
G YQ + +IT+ + + L ++YEI V+A N G G S +V T + P +
Sbjct: 373 DGPYQIKEDITTTRYS---IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 429
Query: 873 PQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDF----- 927
P+NVQ +++TT+ W P + NG+ +GY++ T+ P+
Sbjct: 430 PRNVQARMLSATTMIVQWEEPVEP--NGLIRGYRV------------YYTMEPEHPVGNW 475
Query: 928 --HGVHHGHIT---NLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTE 982
H V +T +L + Y VL FT+ GDGP S P V TQ+ PG +L
Sbjct: 476 QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535
Query: 983 ILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYT 1042
+TS+ +SW P +++ I Y++ + G + + T + TT Y ++ L T Y
Sbjct: 536 RSETSITLSWSPPRQES--IIKYELLFR-EGDHGREVGRTFDPTT-SYVVEDLKPNTEYA 591
Query: 1043 IDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISR 1102
+AA + G G T + P ++ ++ + + +RP
Sbjct: 592 FRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP------- 644
Query: 1103 WIVEGQVGA-IGDEEEWVTLYEEENE--------PDAQMLEIPNLTPYTHYRFRMKQVNI 1153
E GA +G + L E+ E P + + L +T YR
Sbjct: 645 ---ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTE 701
Query: 1154 VGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRW-VPLPDSQYNGNPESVGYR 1212
VGP P S S V++T + P P V + T++R+ W P P Q+ + GY+
Sbjct: 702 VGPGPES-SPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG---QIRGYQ 757
Query: 1213 IKYWR------------SDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA 1260
+ Y R D+ + D E E I L+ Y + + A+ G
Sbjct: 758 VHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGD 817
Query: 1261 GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD 1320
G S+ T+ +V +S + +L W P +LGY++ F +D
Sbjct: 818 GARSKPKVVVTKGAV--LGRPTLSVQQTPEGSLLARW-EPPAGTAEDQVLGYRLQFGRED 874
Query: 1321 LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG- 1379
P +A +G+ K Y ++ A +R G G + +L +D G
Sbjct: 875 STPLATLEFPPSEDRYTA--SGVHKGATYVFRLAARSRGGLGEEAAE-VLSIPEDTPRGH 931
Query: 1380 PPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYRLASS-SPHTFTTVEVGA---T 1433
P + +V + W P P E NG I+ Y +A R A + P T + A
Sbjct: 932 PQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGA 991
Query: 1434 VRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR 1493
T L P++AY ++ A TR+G G T R++ +P +
Sbjct: 992 ENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKN---FKVKMIMKT 1048
Query: 1494 SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRL 1553
S+ L W + SP Y + ++ + + T ++ L+P T Y L
Sbjct: 1049 SVLLSWEFPDNYNSPTPY---------KIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVL 1099
Score = 187 bits (475), Expect = 1e-46
Identities = 198/756 (26%), Positives = 312/756 (41%), Gaps = 80/756 (10%)
Query: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
E V T +S+P A P ++T I +TW S + ++ YK +++D +
Sbjct: 321 EAVAQITVKSLPKA-PGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS--KSQDGPYQ 377
Query: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
+ I ++ + GL YE+ V A IG G PS ++ RT + AP R
Sbjct: 378 IKEDITTTRYS----IGGLSPNSEYEIWVSAVNSIGQGPPSESVVT-RTGEQAPASAPRN 432
Query: 1385 VFPEVRLTSVRIV-WQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLA 1443
V + + IV W+ P EPNG+I GY++ Y + P T L
Sbjct: 433 VQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLL 492
Query: 1444 PESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGS 1503
+ Y R+ A T G G PL + ++ P P L T S+ L W P
Sbjct: 493 EDETYTVRVLAFTSVGDG-PLSDPIQVKTQQGVPGQPMNLRAEARSET--SITLSWSPPR 549
Query: 1504 DGASPIRYFTMQVRELPRGE--WQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGD 1561
S I+Y + RE G +T+ + S+ VV+ L+P T Y RL A + G
Sbjct: 550 Q-ESIIKY-ELLFREGDHGREVGRTFDPTTSY-----VVEDLKPNTEYAFRLAARSPQGL 602
Query: 1562 SDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYREL 1621
F+ TLQ P PP V ++++L+ W+PP E+ NG L GY + YR L
Sbjct: 603 GAFTPVVRQ-RTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661
Query: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
E E + T+T L L+K+ +Y + A+
Sbjct: 662 GSEDPEPKEVNGIP---------------------PTTTQILLEALEKWTQYRITTVAHT 700
Query: 1682 IIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY 1741
+G P S+PV V E P+ P+ V+ L A+ + V W P P Q+G I+GY+++Y
Sbjct: 701 EVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHY 760
Query: 1742 WE-----------------ADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAA 1784
AD+Q ET+ E + + NL T Y ++++A+
Sbjct: 761 VRMEGAEARGPPRIKDVMLADAQWETDDTA-----EYEMVITNLQPETAYSITVAAYTMK 815
Query: 1785 GDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA-ANGILQGYRVVYEPLA 1843
GDG +S P+ T A G P+ L+ + +L W PA A + GYR+ +
Sbjct: 816 GDGARSKPKVVVTKGAVLGRPT-LSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGR-- 872
Query: 1844 PVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSP 1903
+ + + T+E + R+ + KG TY FR+ AR+ E A + + P +
Sbjct: 873 --EDSTPLATLEFPPSEDRYT-ASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPR 929
Query: 1904 GSPR--DVLVTKSASELTLQWTEGHSGDT--PTTGYVIEARPSDEGLWDMFVKDIPRSA- 1958
G P+ + SA + L+W + Y + R + L ++P +A
Sbjct: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG-ALGPARETELPAAAE 988
Query: 1959 --TSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNP 1992
L+L L+ Y+ +V A G G S P
Sbjct: 989 PGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPP 1024
Score = 179 bits (454), Expect = 3e-44
Identities = 206/814 (25%), Positives = 341/814 (41%), Gaps = 109/814 (13%)
Query: 967 TQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNST 1026
T + P A G TE TS+ ++W N Y + D + T
Sbjct: 327 TVKSLPKAPGTPMVTENTATSITITWDSG---NPDPVSYYVIEYKSKSQDGPYQIKEDIT 383
Query: 1027 THEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSA 1086
T Y I GLS + Y I V+AV ++G G + S ++ AP N+ +S +
Sbjct: 384 TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 443
Query: 1087 TLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRF 1146
+Q+ + I + V + + E V +++ N D+ + + +L Y
Sbjct: 444 IVQWEEPVEPNGLIRGYRVYYTM----EPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTV 499
Query: 1147 RMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNP 1206
R+ VG P S +V +T Q P P ++ SETS+ L W P
Sbjct: 500 RVLAFTSVGDGPLSDPIQV-KTQQGVPG-QPMNLRAEARSETSITLSWSP-------PRQ 550
Query: 1207 ESVGYRIKY---WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPW 1263
ES+ IKY +R V + + +E+L+ EY ++ A + G G +
Sbjct: 551 ESI---IKYELLFREGDHGREVGRTFDPTTS--YVVEDLKPNTEYAFRLAARSPQGLGAF 605
Query: 1264 SEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR-AKDLD 1322
+ VVR RT +S PSA P++V +V ST IL++W P + NG ++GY + +R D
Sbjct: 606 TPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSED 665
Query: 1323 PEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPV 1382
PEP+ T LL L K+ Y + +A T +G G S+P+++ RT +D P P
Sbjct: 666 PEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVV-RTDEDVPSAPP 724
Query: 1383 RLVFPE-VRLTSVRIVWQPPE--EPNGIILGYQIAY-----------------RLASSSP 1422
R V E + T++R++W+ P +G I GYQ+ Y LA +
Sbjct: 725 RKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQW 784
Query: 1423 HTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
T T E + T+L PE+AY ++A T +G G + V+ T+ P
Sbjct: 785 ETDDTAEY-----EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS 839
Query: 1483 L-LVPQAEVTAR-------------SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528
+ P+ + AR RLQ+ G + ++P + E P E Y+
Sbjct: 840 VQQTPEGSLLARWEPPAGTAEDQVLGYRLQF--GREDSTP-----LATLEFPPSE-DRYT 891
Query: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVP-GEPPGSVSA 1587
+S H+ V ++L ++ +G+ E ++ +D P G P +A
Sbjct: 892 ASGVHKGATYV---------FRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILEAA 938
Query: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
+ +VL++W PP NG + Y + R EAG+ A+ + P A AE A+
Sbjct: 939 GNASAGTVLLRWLPPVPAERNGAIVKYTVAVR----EAGALGPARETELPAA--AEPGAE 992
Query: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
++ L LK Y++ + A+ G P S PV + ++P+N
Sbjct: 993 NAL------------TLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR-YRTFLRDQVSPKN 1039
Query: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY 1741
+V + + + ++W+ P + YKI Y
Sbjct: 1040 FKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQY 1070
Score = 174 bits (441), Expect = 9e-43
Identities = 225/910 (24%), Positives = 363/910 (39%), Gaps = 117/910 (12%)
Query: 1069 LPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEP 1128
LP AP +++ + S T+ + G +S +++E + + Y+ + +
Sbjct: 331 LPKAPGTPMVTENTATSITITWDSG--NPDPVSYYVIEYKSKSQDGP------YQIKEDI 382
Query: 1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASET 1188
I L+P + Y + VN +G P S S V +T + P AP +V R S T
Sbjct: 383 TTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV-VTRTGEQAPASAPRNVQARMLSAT 441
Query: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKY----------WRSDLQSSAVAQVVSDRLEREFT 1238
++ ++W + N GYR+ Y W+ ++ V LE E
Sbjct: 442 TMIVQW----EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDE-- 495
Query: 1239 IEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWT 1298
Y +++ AF +VG GP S+ ++ +T++ VP P N+ AEA S T I L+W
Sbjct: 496 --------TYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSW- 545
Query: 1299 SVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTR 1358
S P Q+ I+ Y++LFR D E + T S ++ L+ Y ++ A +
Sbjct: 546 SPPRQES---IIKYELLFREGDHGREVGRTF---DPTTSYVVEDLKPNTEYAFRLAARSP 599
Query: 1359 IGNGVPSTPLILERTKDDAPG-PPVRLVFPEVRLTSVRIVWQPP--EEPNGIILGYQIAY 1415
G G TP++ +RT P PP + VR T++ + W+PP E NG ++GY + Y
Sbjct: 600 QGLGA-FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRY 658
Query: 1416 R-LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR 1474
R L S P + T Q L + Y A T G G V+ T++
Sbjct: 659 RPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDED 718
Query: 1475 ERPAPPRELLVPQAEVTARSLRLQWVPGSDGAS-------PIRYFTMQVRE--------- 1518
APPR+ V + A ++R+ W + G + Y M+ E
Sbjct: 719 VPSAPPRK--VEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKD 776
Query: 1519 --LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQD 1576
L +W+T + +E V+ L+P T+Y + + A GD S+ + V T
Sbjct: 777 VMLADAQWET-DDTAEYEM---VITNLQPETAYSITVAAYTMKGDGA-RSKPKVVVTKGA 831
Query: 1577 VPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKN 1636
V G P SV TP S+L +W+PP + + +L GYR+ + G E T
Sbjct: 832 VLGRPTLSVQQTPE--GSLLARWEPPAGTAEDQVL-GYRLQF---------GREDST--- 876
Query: 1637 PIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFV 1696
P+A T+ + + + K Y + A + G +A V + +
Sbjct: 877 PLA------------TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEV-LSI 923
Query: 1697 GEAAPAMAPQNVQVTP-LTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKV 1755
E P PQ ++ +A + + W PP P +NG I Y + EA + + ++
Sbjct: 924 PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETEL 983
Query: 1756 LFLPEP----VVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFS 1811
EP + L+ L T Y + + A G GP S P + RT +P
Sbjct: 984 PAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVK 1043
Query: 1812 EITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTK 1871
I T++ +SW P N Y++ Y L T++V G + L + L
Sbjct: 1044 MIMKTSVLLSWEFPDNYNSPTP-YKIQYNGL----------TLDVDGRTTKKL-ITHLKP 1091
Query: 1872 GVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTP 1931
Y F + R + G LQ +TA A V A + + P
Sbjct: 1092 HTFYNFVLTNRGSSLG-GLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP 1150
Query: 1932 TTGYVIEARP 1941
Y I P
Sbjct: 1151 VQSYFIVMVP 1160
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 245 bits (626), Expect = 3e-64
Identities = 276/1113 (24%), Positives = 463/1113 (41%), Gaps = 127/1113 (11%)
Query: 293 PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF-------GR 345
P + P +++ ++G + + C A+ P +TW + G +++S G
Sbjct: 33 PVFIKVPEDQTGLSGGVASFV-CQATGEPKP--RITWMKKGKKVSSQRFEVIEFDDGAGS 89
Query: 346 RLTISN-PTSADTGPYVCEAALPGSAFEPARATAFLFIIE----PPYFTA---EPESRIS 397
L I D Y C A ++ +A L ++E PP F + P+ ++
Sbjct: 90 VLRIQPLRVQRDEAIYECTAT---NSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKV- 145
Query: 398 AEVEETVDIGCQAMGVPLPTLQWYKDAISIS-RLQNPRYKVLASGGLRIQKLRPEDSGIF 456
E T + C A G P P + W+KD + + N R K L SG L+I+ D G +
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 457 QCFASNEGG---EIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW 513
+C A+N G + Y+ V +AP F+ P V G + L C GAP P + W
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKW 265
Query: 514 KR-ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWN 572
+ + + R +L S ++ A NYTC A ++ G + A+A +TV
Sbjct: 266 MMGAEELTKEDEMPVGRNVLELSNVVRSA--------NYTCVAISSLGMIEATAQVTV-- 315
Query: 573 RTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDN--------VALTPSSTSRI 624
++ PP D VV + TTAT S+ W N + + T
Sbjct: 316 -KALPKPPIDLVVTE-TTAT-----------SVTLTWDSGNSEPVTYYGIQYRAAGTEGP 362
Query: 625 VVEKDGSLLISQTWSG--DIGDYSCEIVSEG----GNDSRMARLEVIELPHSPQNLLVSP 678
E DG + G +Y+ +++ G S R E S V
Sbjct: 363 FQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQA 422
Query: 679 NSSHSHAVVLSWVRPFDGNSPI----LYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLT 734
+ +++ W P + N + +YY + + W H ++ G TV L
Sbjct: 423 RMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG---LLTTVGSLL 479
Query: 735 PARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPE 794
P TY RV A VG G S T ++ + P A P + A ++ I + W PP+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSP-TIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQ 537
Query: 795 TEHNGVLRGYILRYRLA--GLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAG 852
I+ Y L E QQ +T + + DL T Y Q+AA + G
Sbjct: 538 ER--------IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMG 589
Query: 853 LGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA 912
+GVF+ + T Q P+APPQ V ++ STT++ W PPP NG+ Y +
Sbjct: 590 VGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAV 649
Query: 913 DAPEAVTVVTIAPDFHGVHHGH----ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQ 968
D + V G+ H + L+K+T Y V T G GP S+P LV T
Sbjct: 650 DGEDRGRHVV-----DGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 969 EDKP-GAVGHLSFTEILDTSLKVSWQEPL--EKNGIITGYQISWEVYGRNDSR----LTH 1021
ED P G + + T++ V W+ P+ +++G I GYQ+++ + R +
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1022 TLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNI 1081
+ + E I GL+ TTY++ VAA T G G + I + +PG P+ ++IS
Sbjct: 765 VMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT-TTGAVPGRPT-MMISTT 822
Query: 1082 SPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPY 1141
+ +A LQ+ P + + + ++ DE T+ + D Q + L
Sbjct: 823 AMNTALLQWHPPKELPGELLGYRLQ---YCRADEARPNTI---DFGKDDQHFTVTGLHKG 876
Query: 1142 THYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQ 1201
T Y FR+ N G + I+T + P P ++ V + ++ L W P ++
Sbjct: 877 TTYIFRLAAKNRAGLG--EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAE 934
Query: 1202 YNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAG 1261
NG + Y + + D+ S Q ++ + FT+ L+ Y+++++A+ + G+G
Sbjct: 935 RNG--RIISYTVVF--RDINSQQELQNIT--TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
Query: 1262 PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDL 1321
P S ++ RT V +N A T +LL+W VP+ ++ + +KIL+ + +
Sbjct: 989 PLSPSIQSRTM-PVEQVFAKNFRVAAAMKTSVLLSW-EVPDSYKSA--VPFKILYNGQSV 1044
Query: 1322 DPEPRSHIVRGNHTQSALLAGLRKFVLYELQVL 1354
+ + H+ L+A L+ Y ++
Sbjct: 1045 EVD--------GHSMRKLIADLQPNTEYSFVLM 1069
Score = 206 bits (523), Expect = 3e-52
Identities = 217/813 (26%), Positives = 340/813 (41%), Gaps = 88/813 (10%)
Query: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL 1339
P ++ ++T + LTW S + + Y I +RA + + V G T
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTEGPFQE--VDGVATTRYS 375
Query: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIV-W 1398
+ GL F Y +VLA IG G PS + RT + AP P R V + S +V W
Sbjct: 376 IGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQW 434
Query: 1399 QPPEEPNGIILGYQIAYRLASSSP----HTFTTVEVGATVRQFTATDLAPESAYIFRLSA 1454
+PPEEPNG++ GY++ Y S P H T + G T L P Y R+ A
Sbjct: 435 EPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT-DAGLLT---TVGSLLPGITYSLRVLA 490
Query: 1455 KTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARS-LRLQWVPGSDGASPIRYFT 1513
T G G P + T++ PA P + QAEV + + ++L W+ P
Sbjct: 491 FTAVGDGPPSPTIQVKTQQGV-PAQPADF---QAEVESDTRIQLSWL-----LPPQERII 541
Query: 1514 MQVRELPRGEWQTYSSSISHEATAC-VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVT 1572
M E + ++ + T+ ++ L+P T Y+ +L A +D+G F+ EA
Sbjct: 542 MYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEA-R 600
Query: 1573 TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK 1632
T Q P PP V +++V + W PP +S NG++ Y + YEA G +
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSV-----AYEAVDGED-- 653
Query: 1633 TLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPV 1692
+ S + +L L+K+ Y V + A+ +G P S+PV
Sbjct: 654 --------------RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 1693 EVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK 1752
V E P+ P+ V+V PL ++ + V W P P Q+G I+GY++ Y ++
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 1753 ---MKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLA 1809
V+ + LT T Y V+++A+ GDG +S P+ T A PG P+ +
Sbjct: 760 PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMI 819
Query: 1810 FSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDL 1869
+ +T L + W P G L GYR+ Y ++ T++ G + V L
Sbjct: 820 STTAMNTAL-LQWHPPKELPGELLGYRLQY----CRADEARPNTIDF-GKDDQHFTVTGL 873
Query: 1870 TKGVTYFFRVQART-ITYGPELQANITAGPAEGSPGSPRDVLVTKSASELT-LQWTEGHS 1927
KG TY FR+ A+ G E + I P + G P+++ VT + T L W
Sbjct: 874 HKGTTYIFRLAAKNRAGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTSTTELAW----- 927
Query: 1928 GDTPTTGYVIEARPSDEGLWDMFVKDI------PRSATSYTLSLDKLRQGVTYEFRVVAV 1981
D P V+ R + + +DI T +L L+ TY+ +V A
Sbjct: 928 -DPP----VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAW 982
Query: 1982 NEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLI-------VILLVVFALVLHGQ 2034
G G S + + VE F + + M S L+ V F ++ +GQ
Sbjct: 983 TSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQ 1042
Query: 2035 NKKYKNCSTGKGISTM----EESVTLDNGGFAA 2063
+ + S K I+ + E S L N G +A
Sbjct: 1043 SVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSA 1075
Score = 172 bits (436), Expect = 3e-42
Identities = 250/1075 (23%), Positives = 417/1075 (38%), Gaps = 141/1075 (13%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLE----NQLVILATTTSDAGAYYVQAVNEKNGEN 271
T P+P++TW ++G K+ I + + L I A Y GE
Sbjct: 57 TGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEI 116
Query: 272 KTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
TS LS+ + P P+I + P VV + T+ C A P D ++W +
Sbjct: 117 NTS--AKLSVLEEEQLPPGF-PSIDMGP-QLKVVEKARTATMLCAAGGNP--DPEISWFK 170
Query: 332 NGVRITSGLHSFGR-------RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIE 384
+ + + S GR L I + +D G Y C A A A ++ +
Sbjct: 171 DFLPVDPAT-SNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRR 229
Query: 385 -PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGL 443
P F+ P S+ +V++ C A+G P+P ++W A +++ + G
Sbjct: 230 VAPRFSIPPSSQ-EVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDE-----MPVGRN 283
Query: 444 RIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD-GMTAILRCE 502
++ S + C A + G I+ + V + P+D VT+ T++
Sbjct: 284 VLELSNVVRSANYTCVAISSLGMIEATAQVTV----KALPKPPIDLVVTETTATSVTLTW 339
Query: 503 VSGAPKPAITW-------KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYA 555
SG +P + E V R+ + GGL + + A
Sbjct: 340 DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI---GGLSPFSEYA-----FRVLA 391
Query: 556 ANTEG---------------------------SLNASATLTVWNRTSIVHPPEDHVVIKG 588
N+ G L+AS L W P E + +++G
Sbjct: 392 VNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE-----PPEEPNGLVRG 446
Query: 589 TTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCE 648
+ P W K N T ++ GSLL T+S + ++
Sbjct: 447 YRVYYTPDSRRPPN-----AWHKHN-------TDAGLLTTVGSLLPGITYSLRVLAFTA- 493
Query: 649 IVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS 708
V +G + +P P + S + LSW+ P I+Y +V +
Sbjct: 494 -VGDGPPSPTIQVKTQQGVPAQPADFQAEVES--DTRIQLSWLLP-PQERIIMYELVYWA 549
Query: 709 ENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
+ + H P + T+ L P Y+F++ A +++G G ++ T + P
Sbjct: 550 AEDED-QQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTP 606
Query: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNIT---SP 825
SAPP+ ++ + ++ V W PPP NGV+ Y + Y + GE + R++ S
Sbjct: 607 SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE--AVDGEDRGRHVVDGISR 664
Query: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTT 885
E + + L WT+Y + V A+ G G S V T + VP+ PP+ V+ E +NST
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 886 IQFLWNPPPQQFINGINQGYKL--LAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTA 943
+ W P +G +GY++ + P + ++ I+ L T
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM-LAEAQETTISGLTPETT 783
Query: 944 YFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIIT 1003
Y +V +TT GDG S P++V T PG + T ++T+L + W P E G +
Sbjct: 784 YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELL 842
Query: 1004 GYQISWEVYGRNDSRLTHTLN--STTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTI 1061
GY++ Y R D +T++ + + GL TTY +AA G G I
Sbjct: 843 GYRLQ---YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899
Query: 1062 SSGVPPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTS---ISRWIVEGQVGAIGDEEE 1117
+ P DLP G P NL ++ ++ + L + P + + IS +V +
Sbjct: 900 RT--PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDIN------- 950
Query: 1118 WVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPD-VA 1176
+ E +N + L P T Y +++ G P SPS IQ+ P + V
Sbjct: 951 --SQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSRTMPVEQVF 1005
Query: 1177 PTSVTVRTASETSLRLRWVPLPDSQ---------YNGNPESV-GYRIKYWRSDLQ 1221
+ V A +TS+ L W +PDS YNG V G+ ++ +DLQ
Sbjct: 1006 AKNFRVAAAMKTSVLLSW-EVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1059
Score = 158 bits (400), Expect = 5e-38
Identities = 169/621 (27%), Positives = 259/621 (41%), Gaps = 56/621 (9%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQP-PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ 1436
P PP+ LV E TSV + W EP + Y I YR A+ + F V+ AT R
Sbjct: 319 PKPPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYR-AAGTEGPFQEVDGVATTR- 373
Query: 1437 FTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLR 1496
++ L+P S Y FR+ A G G P EA T ++ +PPR V ++A ++
Sbjct: 374 YSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRR--VQARMLSASTML 431
Query: 1497 LQWVPGSDGASPIR----YFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLR 1552
+QW P + +R Y+T R P W +++ T V L P +Y LR
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRR-PPNAWHKHNTDAGLLTT---VGSLLPGITYSLR 487
Query: 1553 LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQ 1612
+ A +GD S T V T Q VP + P A + + + + W P E
Sbjct: 488 VLAFTAVGDGP-PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQE------- 538
Query: 1613 GYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRR 1672
RI EL Y A AE Q T + +S+ T L LK
Sbjct: 539 --RIIMYELVYWA----------------AEDEDQQHKVTFDPTSSYT---LEDLKPDTL 577
Query: 1673 YEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNG 1732
Y + A + +G + +E ++ P+ PQ V + ++ + V+W PPP +S+NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 1733 NIQGYKIYYWEADSQNE-TEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
I Y + Y D ++ + + L L T+Y V + A G GP+S
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 1792 PQQGRTHQAAP-GAPSFLAFSEITSTTLNVSW--GEPAAANGILQGYRVVYEPLAPVQGV 1848
P RT + P G P + + ST ++V W P+ +G ++GY+V Y L +
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757
Query: 1849 SKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGS-PGSPR 1907
+ +V + + LT TY V A T T G ++ G+ PG P
Sbjct: 758 GLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYT-TKGDGARSKPKIVTTTGAVPGRPT 816
Query: 1908 DVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDK 1967
++ T + + LQW GY ++ +DE + D + +T++
Sbjct: 817 MMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI--DFGKDDQHFTVT--G 872
Query: 1968 LRQGVTYEFRVVAVNEAGYGE 1988
L +G TY FR+ A N AG GE
Sbjct: 873 LHKGTTYIFRLAAKNRAGLGE 893
Score = 49.7 bits (117), Expect = 3e-05
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 22/214 (10%)
Query: 1797 THQAAPGAPSFLAFSEITSTTLNVSW----GEPAAANGILQGYRVVYEPLAPVQGVSKVV 1852
T +A P P L +E T+T++ ++W EP GI YR P Q V V
Sbjct: 314 TVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGI--QYRAAGTE-GPFQEVDGVA 370
Query: 1853 TVEVRGNWQRWLKVRDLTKGVTYFFRVQA-RTITYGPELQANITAGPAEGSPGSPRDVLV 1911
T + L+ Y FRV A +I GP +A + A E +P SP +
Sbjct: 371 TTR--------YSIGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQ 421
Query: 1912 TK--SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLR 1969
+ SAS + +QW + GY + P + + K + ++ L
Sbjct: 422 ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKH--NTDAGLLTTVGSLL 479
Query: 1970 QGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
G+TY RV+A G G PS P+ V Q P
Sbjct: 480 PGITYSLRVLAFTAVGDGPPS-PTIQVKTQQGVP 512
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 241 bits (616), Expect = 4e-63
Identities = 277/1122 (24%), Positives = 463/1122 (41%), Gaps = 136/1122 (12%)
Query: 293 PTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF-------GR 345
P + P +++ ++G + + C A+ P +TW + G +++S G
Sbjct: 33 PVFIKVPEDQTGLSGGVASFV-CQATGEPKP--RITWMKKGKKVSSQRFEVIEFDDGAGS 89
Query: 346 RLTISN-PTSADTGPYVCEAALPGSAFEPARATAFLFIIE----PPYFTA---EPESRIS 397
L I D Y C A ++ +A L ++E PP F + P+ ++
Sbjct: 90 VLRIQPLRVQRDEAIYECTAT---NSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKV- 145
Query: 398 AEVEETVDIGCQAMGVPLPTLQWYKDAISIS-RLQNPRYKVLASGGLRIQKLRPEDSGIF 456
E T + C A G P P + W+KD + + N R K L SG L+I+ D G +
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 457 QCFASNEGG---EIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW 513
+C A+N G + Y+ V +AP F+ P V G + L C GAP P + W
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKW 265
Query: 514 KR-ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWN 572
+ + + R +L S ++ A NYTC A ++ G + A+A +TV
Sbjct: 266 MMGAEELTKEDEMPVGRNVLELSNVVRSA--------NYTCVAISSLGMIEATAQVTV-- 315
Query: 573 RTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDN--------VALTPSSTSRI 624
++ PP D VV + TTAT S+ W N + + T
Sbjct: 316 -KALPKPPIDLVVTE-TTAT-----------SVTLTWDSGNSEPVTYYGIQYRAAGTEGP 362
Query: 625 VVEKDGSLLISQTWSG--DIGDYSCEIVSEG----GNDSRMARLEVIELPHSPQNLLVSP 678
E DG + G +Y+ +++ G S R E S V
Sbjct: 363 FQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQA 422
Query: 679 NSSHSHAVVLSWVRPFDGNSPI----LYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLT 734
+ +++ W P + N + +YY + + W H ++ G TV L
Sbjct: 423 RMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG---LLTTVGSLL 479
Query: 735 PARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPE 794
P TY RV A VG G S T ++ + P A P + A ++ I + W PP+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSP-TIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQ 537
Query: 795 TEHNGVLRGYILRYRLA--GLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAG 852
I+ Y L E QQ +T + + DL T Y Q+AA + G
Sbjct: 538 ER--------IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMG 589
Query: 853 LGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA 912
+GVF+ + T Q P+APPQ V ++ STT++ W PPP NG+ Y +
Sbjct: 590 VGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAV 649
Query: 913 DAPEAVTVVTIAPDFHGVHHGH----ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQ 968
D + V G+ H + L+K+T Y V T G GP S+P LV T
Sbjct: 650 DGEDRGRHVV-----DGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 969 EDKP-GAVGHLSFTEILDTSLKVSWQEPL--EKNGIITGYQISWEVYGRNDSRLTHTL-- 1023
ED P G + + T++ V W+ P+ +++G I GYQ+++ + R +
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1024 -----------NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGA 1072
S +E I GL+ TTY++ VAA T G G + I + +PG
Sbjct: 765 VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT-TTGAVPGR 823
Query: 1073 PSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQM 1132
P+ ++IS + +A LQ+ P + + + ++ DE T+ + D Q
Sbjct: 824 PT-MMISTTAMNTALLQWHPPKELPGELLGYRLQ---YCRADEARPNTI---DFGKDDQH 876
Query: 1133 LEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRL 1192
+ L T Y FR+ N G + I+T + P P ++ V + ++ L
Sbjct: 877 FTVTGLHKGTTYIFRLAAKNRAGLG--EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTEL 934
Query: 1193 RWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQM 1252
W P ++ NG + Y + + D+ S Q ++ + FT+ L+ Y++++
Sbjct: 935 AWDPPVLAERNG--RIISYTVVF--RDINSQQELQNIT--TDTRFTLTGLKPDTTYDIKV 988
Query: 1253 QAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGY 1312
+A+ + G+GP S ++ RT V +N A T +LL+W VP+ ++ + +
Sbjct: 989 RAWTSKGSGPLSPSIQSRTM-PVEQVFAKNFRVAAAMKTSVLLSW-EVPDSYKSA--VPF 1044
Query: 1313 KILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVL 1354
KIL+ + ++ + H+ L+A L+ Y ++
Sbjct: 1045 KILYNGQSVEVD--------GHSMRKLIADLQPNTEYSFVLM 1078
Score = 202 bits (515), Expect = 2e-51
Identities = 219/823 (26%), Positives = 345/823 (41%), Gaps = 99/823 (12%)
Query: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL 1339
P ++ ++T + LTW S + + Y I +RA + + V G T
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTEGPFQE--VDGVATTRYS 375
Query: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIV-W 1398
+ GL F Y +VLA IG G PS + RT + AP P R V + S +V W
Sbjct: 376 IGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQW 434
Query: 1399 QPPEEPNGIILGYQIAYRLASSSP----HTFTTVEVGATVRQFTATDLAPESAYIFRLSA 1454
+PPEEPNG++ GY++ Y S P H T + G T L P Y R+ A
Sbjct: 435 EPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT-DAGLLT---TVGSLLPGITYSLRVLA 490
Query: 1455 KTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARS-LRLQWVPGSDGASPIRYFT 1513
T G G P + T++ PA P + QAEV + + ++L W+ P
Sbjct: 491 FTAVGDGPPSPTIQVKTQQGV-PAQPADF---QAEVESDTRIQLSWL-----LPPQERII 541
Query: 1514 MQVRELPRGEWQTYSSSISHEATAC-VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVT 1572
M E + ++ + T+ ++ L+P T Y+ +L A +D+G F+ EA
Sbjct: 542 MYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEA-R 600
Query: 1573 TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK 1632
T Q P PP V +++V + W PP +S NG++ Y + YEA G +
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSV-----AYEAVDGED-- 653
Query: 1633 TLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPV 1692
+ S + +L L+K+ Y V + A+ +G P S+PV
Sbjct: 654 --------------RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 1693 EVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK 1752
V E P+ P+ V+V PL ++ + V W P P Q+G I+GY++ Y ++ E
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN-GEPRG 758
Query: 1753 MKVL---------FLPEP----VVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQ 1799
+ ++ + PE + LT T Y V+++A+ GDG +S P+ T
Sbjct: 759 LPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTG 818
Query: 1800 AAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGN 1859
A PG P+ + + +T L + W P G L GYR+ Y ++ T++ G
Sbjct: 819 AVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQY----CRADEARPNTIDF-GK 872
Query: 1860 WQRWLKVRDLTKGVTYFFRVQART-ITYGPELQANITAGPAEGSPGSPRDVLVTKSASEL 1918
+ V L KG TY FR+ A+ G E + I P + G P+++ VT +
Sbjct: 873 DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTST 931
Query: 1919 T-LQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDI------PRSATSYTLSLDKLRQG 1971
T L W D P V+ R + + +DI T +L L+
Sbjct: 932 TELAW------DPP----VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPD 981
Query: 1972 VTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLI-------VILL 2024
TY+ +V A G G S + + VE F + + M S L+
Sbjct: 982 TTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSA 1041
Query: 2025 VVFALVLHGQNKKYKNCSTGKGISTM----EESVTLDNGGFAA 2063
V F ++ +GQ+ + S K I+ + E S L N G +A
Sbjct: 1042 VPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSA 1084
Score = 172 bits (437), Expect = 3e-42
Identities = 253/1083 (23%), Positives = 419/1083 (38%), Gaps = 148/1083 (13%)
Query: 216 TSYPRPQVTWFREGHKIIPSNRIAITLE----NQLVILATTTSDAGAYYVQAVNEKNGEN 271
T P+P++TW ++G K+ I + + L I A Y GE
Sbjct: 57 TGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEI 116
Query: 272 KTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
TS LS+ + P P+I + P VV + T+ C A P D ++W +
Sbjct: 117 NTS--AKLSVLEEEQLPPGF-PSIDMGP-QLKVVEKARTATMLCAAGGNP--DPEISWFK 170
Query: 332 NGVRITSGLHSFGR-------RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIE 384
+ + + S GR L I + +D G Y C A A A ++ +
Sbjct: 171 DFLPVDPAT-SNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRR 229
Query: 385 -PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGL 443
P F+ P S+ +V++ C A+G P+P ++W A +++ + G
Sbjct: 230 VAPRFSIPPSSQ-EVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDE-----MPVGRN 283
Query: 444 RIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD-GMTAILRCE 502
++ S + C A + G I+ + V + P+D VT+ T++
Sbjct: 284 VLELSNVVRSANYTCVAISSLGMIEATAQVTV----KALPKPPIDLVVTETTATSVTLTW 339
Query: 503 VSGAPKPAITW-------KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYA 555
SG +P + E V R+ + GGL + + A
Sbjct: 340 DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSI---GGLSPFSEYA-----FRVLA 391
Query: 556 ANTEG---------------------------SLNASATLTVWNRTSIVHPPEDHVVIKG 588
N+ G L+AS L W P E + +++G
Sbjct: 392 VNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWE-----PPEEPNGLVRG 446
Query: 589 TTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCE 648
+ P W K N T ++ GSLL T+S + ++
Sbjct: 447 YRVYYTPDSRRPPN-----AWHKHN-------TDAGLLTTVGSLLPGITYSLRVLAFTA- 493
Query: 649 IVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS 708
V +G + +P P + S + LSW+ P I+Y +V +
Sbjct: 494 -VGDGPPSPTIQVKTQQGVPAQPADFQAEVES--DTRIQLSWLLP-PQERIIMYELVYWA 549
Query: 709 ENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
+ + H P + T+ L P Y+F++ A +++G G ++ T + P
Sbjct: 550 AEDED-QQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTP 606
Query: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNIT---SP 825
SAPP+ ++ + ++ V W PPP NGV+ Y + Y + GE + R++ S
Sbjct: 607 SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE--AVDGEDRGRHVVDGISR 664
Query: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTT 885
E + + L WT+Y + V A+ G G S V T + VP+ PP+ V+ E +NST
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 886 IQFLWNPPPQQFINGINQGYKLL------AWPADAPEAVTVVTI----APDFHGVHHGHI 935
+ W P +G +GY++ P P V+ P+ + I
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
Query: 936 TNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEP 995
+ L T Y +V +TT GDG S P++V T PG + T ++T+L + W P
Sbjct: 785 SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPP 843
Query: 996 LEKNGIITGYQISWEVYGRNDSRLTHTLN--STTHEYKIQGLSSLTTYTIDVAAVTAVGT 1053
E G + GY++ Y R D +T++ + + GL TTY +AA G
Sbjct: 844 KELPGELLGYRLQ---YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900
Query: 1054 GLVTSSTISSGVPPDLP-GAPSNLVISNISPRSATLQFRPGYDGKTS---ISRWIVEGQV 1109
G I + P DLP G P NL ++ ++ + L + P + + IS +V +
Sbjct: 901 GEEFEKEIRT--PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDI 958
Query: 1110 GAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL 1169
+ E +N + L P T Y +++ G P SPS IQ+
Sbjct: 959 N---------SQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR 1006
Query: 1170 QAPPD-VAPTSVTVRTASETSLRLRWVPLPDSQ---------YNGNPESV-GYRIKYWRS 1218
P + V + V A +TS+ L W +PDS YNG V G+ ++ +
Sbjct: 1007 TMPVEQVFAKNFRVAAAMKTSVLLSW-EVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIA 1065
Query: 1219 DLQ 1221
DLQ
Sbjct: 1066 DLQ 1068
Score = 156 bits (394), Expect = 2e-37
Identities = 170/630 (26%), Positives = 260/630 (41%), Gaps = 65/630 (10%)
Query: 1378 PGPPVRLVFPEVRLTSVRIVWQP-PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ 1436
P PP+ LV E TSV + W EP + Y I YR A+ + F V+ AT R
Sbjct: 319 PKPPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYR-AAGTEGPFQEVDGVATTR- 373
Query: 1437 FTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLR 1496
++ L+P S Y FR+ A G G P EA T ++ +PPR V ++A ++
Sbjct: 374 YSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRR--VQARMLSASTML 431
Query: 1497 LQWVPGSDGASPIR----YFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLR 1552
+QW P + +R Y+T R P W +++ T V L P +Y LR
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRR-PPNAWHKHNTDAGLLTT---VGSLLPGITYSLR 487
Query: 1553 LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQ 1612
+ A +GD S T V T Q VP + P A + + + + W P E
Sbjct: 488 VLAFTAVGDGP-PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQE------- 538
Query: 1613 GYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRR 1672
RI EL Y A AE Q T + +S+ T L LK
Sbjct: 539 --RIIMYELVYWA----------------AEDEDQQHKVTFDPTSSYT---LEDLKPDTL 577
Query: 1673 YEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNG 1732
Y + A + +G + +E ++ P+ PQ V + ++ + V+W PPP +S+NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 1733 NIQGYKIYYWEADSQNE-TEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
I Y + Y D ++ + + L L T+Y V + A G GP+S
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 1792 PQQGRTHQAAP-GAPSFLAFSEITSTTLNVSW--GEPAAANGILQGYRVVYEPLAPVQGV 1848
P RT + P G P + + ST ++V W P+ +G ++GY+V Y L +
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757
Query: 1849 SKVVTVEVRGNWQRW---------LKVRDLTKGVTYFFRVQARTITYGPELQANITAGPA 1899
+ +V +W + LT TY V A T T G ++
Sbjct: 758 GLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYT-TKGDGARSKPKIVTT 816
Query: 1900 EGS-PGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSA 1958
G+ PG P ++ T + + LQW GY ++ +DE + D +
Sbjct: 817 TGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI--DFGKDD 874
Query: 1959 TSYTLSLDKLRQGVTYEFRVVAVNEAGYGE 1988
+T++ L +G TY FR+ A N AG GE
Sbjct: 875 QHFTVT--GLHKGTTYIFRLAAKNRAGLGE 902
Score = 49.7 bits (117), Expect = 3e-05
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 22/214 (10%)
Query: 1797 THQAAPGAPSFLAFSEITSTTLNVSW----GEPAAANGILQGYRVVYEPLAPVQGVSKVV 1852
T +A P P L +E T+T++ ++W EP GI YR P Q V V
Sbjct: 314 TVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGI--QYRAAGTE-GPFQEVDGVA 370
Query: 1853 TVEVRGNWQRWLKVRDLTKGVTYFFRVQA-RTITYGPELQANITAGPAEGSPGSPRDVLV 1911
T + L+ Y FRV A +I GP +A + A E +P SP +
Sbjct: 371 TTR--------YSIGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQ 421
Query: 1912 TK--SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLR 1969
+ SAS + +QW + GY + P + + K + ++ L
Sbjct: 422 ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKH--NTDAGLLTTVGSLL 479
Query: 1970 QGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
G+TY RV+A G G PS P+ V Q P
Sbjct: 480 PGITYSLRVLAFTAVGDGPPS-PTIQVKTQQGVP 512
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 239 bits (609), Expect = 3e-62
Identities = 293/1295 (22%), Positives = 516/1295 (39%), Gaps = 215/1295 (16%)
Query: 721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780
+G T V VS + P Y + +++ Y++ +R++ PP +
Sbjct: 12 IGTSETQVDVSNVVPGTRYDITISSISTT----YTSPVTRIVTTNVTKPGPPVFLAGERV 67
Query: 781 TNQSIMVQWQPPPETEHNGVLRGYILRYR--LAGLPGEYQQRNITSPEVNYCLVTDLIIW 838
+ I++ W PP NG + YI++Y+ + Y Q + P+ L+T+L
Sbjct: 68 GSAGILLSWNTPPNP--NGRIISYIVKYKEVCPWMQTVYTQVR-SKPDSLEVLLTNLNPG 124
Query: 839 TQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQ--- 895
T YEI+VAA N AG+GVFS T + P N+ EA N++ ++ +W P Q
Sbjct: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAP-GKVVNLTVEAYNASAVKLIWYLPRQPNG 183
Query: 896 --------------------------QFING----INQGYKLLAWPADAPEAVTVVTIAP 925
+ G N+ + W +P + T+ + P
Sbjct: 184 KITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP-SPTLGRVTP 242
Query: 926 DFHGVHHGH------------------ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWT 967
H +T+L+ +T Y V TT ST +V T
Sbjct: 243 PSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRT 300
Query: 968 QEDKP-GAVGHLSFTEILDTSLKVSWQEPLEKNGIITG-YQISWEVYGRNDSRLTHTLNS 1025
E P G + I S + W P I+TG + E+YG + L ++
Sbjct: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPT----IVTGKFSYRVELYGPSGRILDNSTKD 356
Query: 1026 TTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRS 1085
++ L+ T Y + +AA T+ GTG S IS PPD+PGA +L ++ +
Sbjct: 357 L--KFAFTNLTPFTMYDVYIAAETSAGTG--PKSNISVFTPPDVPGAVFDLQLAEVESTQ 412
Query: 1086 ATLQFRPGYDGKTSISRW----------------IVEGQVGAIGDE---------EEWVT 1120
+ ++ I+++ ++ G I D E V
Sbjct: 413 VRITWKKPRQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVG 472
Query: 1121 LYEEENEPDAQMLE----IPNLTPYTHYRFRMKQVNIVGPSPYSPS-----------SRV 1165
LYE E + + I N P ++ R + + P + + S V
Sbjct: 473 LYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYV 532
Query: 1166 IQTL-----------------QAPPDV--------APTSVTV---RTASETSLRLRWVPL 1197
I+ L + PP V P+S+ + + S +S+ L W P
Sbjct: 533 IRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDP- 591
Query: 1198 PDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNA 1257
+Y N + Y I + +L ++ Q+ + ++ F I L+++ +Y++++ A
Sbjct: 592 --PEY-PNGKITHYTI--YAMELDTNRAFQITT--IDNSFLITGLKKYTKYKMRVAASTH 644
Query: 1258 VGAGPWSEV--VRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKIL 1315
VG SE + RT E P ++P++V V++ +I L W+ P + NG+I+ Y++L
Sbjct: 645 VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWS--PPEKPNGIIIAYEVL 702
Query: 1316 FRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKD 1375
++ D + ++ T +L LR LY + V ++TR G+G + L+ RT +
Sbjct: 703 YKNID------TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSE 756
Query: 1376 DAP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLAS-SSPHTFTTVEVGAT 1433
P P + + + + + + PP PNGII Y I + ++ + T T +
Sbjct: 757 TVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQN 816
Query: 1434 VRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR 1493
++ L + YI +SA T +G G I TE+ +PP++ V Q ++
Sbjct: 817 IKV-----LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQ--LSGV 869
Query: 1494 SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS-SSISHEATACVVDRLRPFTSYKLR 1552
+++L W P + I Y+T+ V W S +I+ T+ + L Y
Sbjct: 870 TVKLSWQPPLEPNGIILYYTVYV-------WNRSSLKTINVTETSLELSDLDYNVEYSAY 922
Query: 1553 LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQ 1612
+ A+ GD S + T + P +PP V ++SS+++ W PP NG++Q
Sbjct: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPP--SKPNGIIQ 980
Query: 1613 GYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRR 1672
Y +YYR + T LH E+T TV ST+ + + Y
Sbjct: 981 YYSVYYR---------NTSGTFMQNFTLH-EVTNDFDNMTV-----STIIDKLTIFSY-- 1023
Query: 1673 YEVIMTAYNIIGESPASAP-VEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQN 1731
Y +TA +G S+ +EV+ + P N+ ++++ + V+W PP +
Sbjct: 1024 YTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN-- 1081
Query: 1732 GNIQGYKIYYWEADSQNETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKS 1790
G YY Q ++ L E + NL +T Y++ I+ G
Sbjct: 1082 ----GLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTY 1137
Query: 1791 DPQ-QGRTHQAAP-GAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGV 1848
Q +T + P +P F ++ST++ +SW P NG + Y + + P +
Sbjct: 1138 TAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ--GPNENY 1195
Query: 1849 SKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART 1883
S + + ++ + +L+ Y F ART
Sbjct: 1196 SFITS-------DNYIILEELSPFTLYSFFAAART 1223
Score = 227 bits (578), Expect = 1e-58
Identities = 270/1167 (23%), Positives = 463/1167 (39%), Gaps = 148/1167 (12%)
Query: 670 SPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVT 729
SPQ++ V ++ + L W P N I+ Y V ++ + + S T +
Sbjct: 668 SPQDVEVIDVTADE--IRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTST-----TDII 720
Query: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
+ L P Y V + G G + + E P + P+NI ++ I + +
Sbjct: 721 LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
Query: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYN 849
PP + NG+++ Y + Y E + N TS N + L +TQY I+V+A
Sbjct: 781 LPP--SSPNGIIQKYTI-YLKRSNGNEERTINTTSLTQN---IKVLKKYTQYIIEVSAST 834
Query: 850 GAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLA 909
G GV S ++ T + P +PPQ+ + ++ T++ W PP + NGI Y +
Sbjct: 835 LKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEP--NGIILYYTVYV 892
Query: 910 WPADAPEAVTVVTIA-----PDFHGVHHGHITNLKKFTAYFT--SVLCFTTPGDGPPSTP 962
W + + + V + D++ + ++T +F T +++ F TP P P
Sbjct: 893 WNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPP 952
Query: 963 QLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT 1022
+ V+ + + +S+ + W P + NGII Y VY RN S T
Sbjct: 953 KDVY-------------YANLSSSSIILFWTPPSKPNGIIQYY----SVYYRNTSG-TFM 994
Query: 1023 LNSTTHEYK-----------IQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP- 1070
N T HE I L+ + YT + A T+VG G +S I D+P
Sbjct: 995 QNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPE 1054
Query: 1071 GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDA 1130
G NL +IS + + + P + ++ + YE
Sbjct: 1055 GFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYE------- 1107
Query: 1131 QMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSL 1190
+ + NL YT Y ++ G S + I+T + P+ +P T + S TS+
Sbjct: 1108 RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSV 1167
Query: 1191 RLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYEL 1250
L W D N + Y + + S + + +EEL + Y
Sbjct: 1168 LLSW----DPPVKPNGAIISYDLTLQGPNENYSFITS------DNYIILEELSPFTLYSF 1217
Query: 1251 QMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLIL 1310
A G GP S ++ T ESVP A P+N++ +S + L W+ P G++
Sbjct: 1218 FAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS--PSPLPGGIVK 1274
Query: 1311 GYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLIL 1370
Y + D +I A L GL Y ++V AFT++GNG + ++
Sbjct: 1275 VYSFKIHEHETDTIYYKNI--SGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVK 1332
Query: 1371 ERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEV 1430
T++ P + SV + W PP++ NGII Y + S+ +V
Sbjct: 1333 FTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNST--------KV 1384
Query: 1431 GATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEV 1490
+T L ++Y+F++ A T G G+ V T + P + ++V
Sbjct: 1385 SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTN---IAFSDV 1441
Query: 1491 TARSLRLQWVPGSDGASPIRYF-----TMQVRELPRGEWQT------------YSSSISH 1533
+ S L W+ + + YF T Q+R EW++ Y + ++
Sbjct: 1442 QSTSATLTWIRPD---TILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498
Query: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
E V L+ F Y+ ++ A+ + G + +S + TL P PP +V +
Sbjct: 1499 E----TVYGLKKFRWYRFQVAASTNAGYGN-ASNWISTKTLPGPPDGPPENVHVVATSPF 1553
Query: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
S+ I W P ++ G Y + K++ N + + +
Sbjct: 1554 SISISWSEP------AVITGPTCYL----------IDVKSVDND---------EFNISFI 1588
Query: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAY--NIIG---ESPASAPVEVFVGEAAPAMAPQNV 1708
S+ + E+ L+ + RY V++TA+ NI E +SA + V E+AP P N+
Sbjct: 1589 KSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNM 1648
Query: 1709 --QVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEP----V 1762
Q P ++ ++T+ PP NGNIQ Y+ + D + + + + +
Sbjct: 1649 TFQKIPDEVTKFQLTF--LPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVI 1706
Query: 1763 VRLKNLTSHTKYLVSISAFNAAGDGPK 1789
L+ L Y +S+ A N+AG GPK
Sbjct: 1707 AMLEGLKGGHTYNISVYAVNSAGAGPK 1733
Score = 216 bits (551), Expect = 2e-55
Identities = 312/1343 (23%), Positives = 537/1343 (39%), Gaps = 173/1343 (12%)
Query: 717 HLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET--SRLMLPEEPPSAPPKN 774
+++++ E + L P + V A +G G + + +R +P KN
Sbjct: 520 YITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKN 579
Query: 775 IVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTD 834
I +S SI++ W PP G I Y + + + + + N L+T
Sbjct: 580 ISSS-----SILLYWDPPEYPN------GKITHYTIYAMELDTNRAFQITTIDNSFLITG 628
Query: 835 LIIWTQYEIQVAAYNGAGLGVFSRA--VTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNP 892
L +T+Y+++VAA G S + T + P + PQ+V+ V + I+ W+P
Sbjct: 629 LKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSP 688
Query: 893 PPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFT 952
P + NGI Y++L D T+ + NL+ T Y SV +T
Sbjct: 689 PEKP--NGIIIAYEVLYKNID--------TLYMKNTSTTDIILRNLRPHTLYNISVRSYT 738
Query: 953 TPGDGPPSTPQL-VWTQEDKP-GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWE 1010
G G + L V T E P A ++++ I +++S+ P NGII Y I +
Sbjct: 739 RFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK 798
Query: 1011 VYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP 1070
N+ R T+N+T+ I+ L T Y I+V+A T G G V S+ IS D P
Sbjct: 799 RSNGNEER---TINTTSLTQNIKVLKKYTQYIIEVSASTLKGEG-VRSAPISILTEEDAP 854
Query: 1071 GA-PSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
+ P + + +S + L ++P + I + V + + T+ E
Sbjct: 855 DSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTV-----YVWNRSSLKTINVTETS-- 907
Query: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
LE+ +L Y + G + QT + P P V S +S
Sbjct: 908 ---LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSS 964
Query: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSD----LQSSAVAQVVS--DRLEREFTIEELE 1243
+ L W P S+ NG + Y Y+R+ +Q+ + +V + D + I++L
Sbjct: 965 IILFWT--PPSKPNG---IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLT 1019
Query: 1244 EWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPE 1302
+ Y + A +VG G S+++ T + +P N++ E++SST I ++W VP
Sbjct: 1020 IFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW--VPP 1077
Query: 1303 QDQNGLILGYKILFRAKDLDPEPRSHI--VRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
NGL+ Y L L PR H+ + +S L K+ Y L++ T G
Sbjct: 1078 AQPNGLVFYYVSLI----LQQTPR-HVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKG 1132
Query: 1361 NGVPSTPLILERTKDDAP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLAS 1419
T + +T++D P P+ F + TSV + W PP +PNG I+ Y + +
Sbjct: 1133 FSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ-GP 1191
Query: 1420 SSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAP 1479
+ ++F T + +L+P + Y F +A+TR+G G P T++ AP
Sbjct: 1192 NENYSFITSD-----NYIILEELSPFTLYSFFAAARTRKGLG-PSSILFFYTDESVPLAP 1245
Query: 1480 PRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQT-YSSSISHEATAC 1538
P+ L + T+ + L+W P ++ ++ ++ E E T Y +IS T
Sbjct: 1246 PQNLTL--INCTSDFVWLKWSPSPLPGGIVKVYSFKIHE---HETDTIYYKNISGFKTEA 1300
Query: 1539 VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQ 1598
+ L P ++Y +R+ A +G+ + S TT + VP + ++ + SVL++
Sbjct: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP-DVVQNMQCMATSWQSVLVK 1359
Query: 1599 WQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658
W PP+ NG++ Y + + T +L A +S+ +ST
Sbjct: 1360 WDPPK--KANGIITQYMVTVERNSTKVSPQDHMYTF-------IKLLANTSYVFKVRAST 1410
Query: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718
S GE S + E P++ P N+ + + ++
Sbjct: 1411 SA-----------------------GEGDESTCHVSTLPETVPSV-PTNIAFSDVQSTSA 1446
Query: 1719 EVTWDPPPPESQNGNIQGYKI---------YYWEADSQNETEKMKVLF---LPEPVVRLK 1766
+TW P++ G Q YKI WE++ E +K++ L+ L E V
Sbjct: 1447 TLTW--IRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETV--Y 1502
Query: 1767 NLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSEITSTTLNVSWGEP 1825
L Y ++A AG G S+ +T P G P + + ++++SW EP
Sbjct: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
Query: 1826 AAANGILQGYRVVYEPLAPVQGVSKVVTVE-----VRGNWQ-RWLKVRDLTKGVTYFFRV 1879
A G P + V V E ++ N + + ++++DL Y +
Sbjct: 1563 AVITG----------PTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVI 1612
Query: 1880 QARTITYGPELQANITAGPAEGSPGSPRDVLVTKSAS-------------------ELTL 1920
A T NI+A EG + V +SA +LT
Sbjct: 1613 TAFT--------GNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTF 1664
Query: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
+G+ ++ + + I ++ T L+ L+ G TY V A
Sbjct: 1665 LPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYA 1724
Query: 1981 VNEAGYGEPSNPSTAVSAQVEAP 2003
VN AG G P P ++ ++AP
Sbjct: 1725 VNSAGAG-PKVP-MRITMDIKAP 1745
Score = 134 bits (336), Expect = 1e-30
Identities = 216/992 (21%), Positives = 372/992 (37%), Gaps = 106/992 (10%)
Query: 579 PPEDHVV--IKGTTATLHCGATHDPRVSLRY----VWKKDNV-ALTPSSTSRIVVEKDGS 631
PP+D V + G T L +P + Y VW + ++ + + TS + + D +
Sbjct: 857 PPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYN 916
Query: 632 LLISQ--TWSGDIGDYSCEIVSEGGNDSRMARLEVIE-LPHSPQNLLVSPNSSHSHAVVL 688
+ S T S GD G S + + E P P + N S S +++L
Sbjct: 917 VEYSAYVTASTRFGD--------GKTRSNIISFQTPEGAPSDPPKDVYYANLSSS-SIIL 967
Query: 689 SWVRPFDGNSPILYYIVELSENNSPWKVH--LSNVGPEMTGVTVSGLTPART----YQFR 742
W P N I YY V + + + L V + +TVS + T Y F
Sbjct: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
Query: 743 VCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802
+ A VG G S++ + ++ P N+ ++ +I V W PP + NG++
Sbjct: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQP--NGLVF 1085
Query: 803 GYILRYRLAGLPGEYQQRNITSPEVNY---CLVTDLIIWTQYEIQVAAYNGAGLG-VFSR 858
Y+ L + R++ P V Y +L +T Y +++ G ++
Sbjct: 1086 YYV------SLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTA 1139
Query: 859 AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL-LAWPADAPEA 917
+ T + VP P + ++ST++ W+PP + NG Y L L P +
Sbjct: 1140 QLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKP--NGAIISYDLTLQGPNENYSF 1197
Query: 918 VTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVG- 976
+T ++ + L FT Y T G GP S +T E P A
Sbjct: 1198 IT---------SDNYIILEELSPFTLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQ 1247
Query: 977 HLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLS 1036
+L+ + + W GI+ Y + D+ ++ E K+ GL
Sbjct: 1248 NLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEH-ETDTIYYKNISGFKTEAKLVGLE 1306
Query: 1037 SLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDG 1096
++TY+I V+A T VG G S+ + +P N+ S +S +++ P
Sbjct: 1307 PVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKA 1366
Query: 1097 KTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGP 1156
I++++V V + P M L T Y F+++ G
Sbjct: 1367 NGIITQYMVT------------VERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGE 1414
Query: 1157 SPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS------QYNGNPESVG 1210
S+ + TL PT++ TS L W+ PD+ Y +
Sbjct: 1415 G--DESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI-RPDTILGYFQNYKITTQLRA 1471
Query: 1211 YRIKYWRSD--LQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVR 1268
+ K W S+ ++ + + L E T+ L+++ Y Q+ A G G S +
Sbjct: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEE-TVYGLKKFRWYRFQVAASTNAGYGNASNWIS 1530
Query: 1269 GRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILG---YKILFRAKDLDPEP 1325
+T P PENV A S I ++W+ + +I G Y I ++ D D
Sbjct: 1531 TKTLPGPPDGPPENVHVVATSPFSISISWS------EPAVITGPTCYLIDVKSVDNDEFN 1584
Query: 1326 RSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGN-------GVPSTPLILERTKDDAP 1378
S I ++ + L F Y + + AFT GN G S +I+ +
Sbjct: 1585 ISFIKSNEENKTIEIKDLEIFTRYSVVITAFT--GNISAAYVEGKSSAEMIVTTLESAPK 1642
Query: 1379 GPPVRLVFPEV--RLTSVRIVWQPPEEPNGIILGYQ-IAYRLASSSPHTFTTVEVGATVR 1435
PP + F ++ +T ++ + PP +PNG I YQ + YR + + +
Sbjct: 1643 DPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTN 1702
Query: 1436 QFTATDL-APESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR- 1493
F L + + + +S G + + T + PA P+ P + T +
Sbjct: 1703 TFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKL 1762
Query: 1494 -------SLRLQWVPGSDGASPIRYFTMQVRE 1518
++R+ SD PI+ + V E
Sbjct: 1763 LVTSTTITIRMPICYYSDDHGPIKNVQVLVTE 1794
Score = 87.8 bits (216), Expect = 1e-16
Identities = 108/462 (23%), Positives = 188/462 (40%), Gaps = 65/462 (14%)
Query: 1425 FTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL 1484
F + +G + Q +++ P + Y +S+ + + P+ T I T +P PP +
Sbjct: 7 FLLLFIGTSETQVDVSNVVPGTRYDITISSISTT-YTSPV--TRIVTTNVTKPGPP--VF 61
Query: 1485 VPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISH-EATACVVDRL 1543
+ V + + L W + I + ++ +E+ Y+ S ++ ++ L
Sbjct: 62 LAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNL 121
Query: 1544 RPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPR 1603
P T+Y++++ A N G FS + T + PG+ +++ + S+V + W PR
Sbjct: 122 NPGTTYEIKVAAENSAGIGVFS-DPFLFQTAESAPGKVV-NLTVEAYNASAVKLIWYLPR 179
Query: 1604 DESLNGLLQGYRIYYREL----------------------EYEAGSGTEAKTLKNPIALH 1641
NG + ++I + E S + + +P
Sbjct: 180 QP--NGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTL 237
Query: 1642 AELTAQSSFKTVNSSSTSTMCEL------------THLKKYRRYEVIMTAYNIIGESPAS 1689
+T S +T +SSST T E+ THL+ Y Y ++A E+
Sbjct: 238 GRVTPPS--RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATT--EAGYI 293
Query: 1690 APVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQ-- 1747
V E+ P PQN +T + WDPP + + Y++ + +
Sbjct: 294 DSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFS---YRVELYGPSGRIL 350
Query: 1748 -NETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPS 1806
N T+ +K F NLT T Y V I+A +AG GPKS+ T PGA
Sbjct: 351 DNSTKDLKFAFT--------NLTPFTMYDVYIAAETSAGTGPKSNISVF-TPPDVPGAVF 401
Query: 1807 FLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGV 1848
L +E+ ST + ++W +P NGI+ YRV + L P G+
Sbjct: 402 DLQLAEVESTQVRITWKKPRQPNGIINQYRV--KVLVPETGI 441
Score = 77.4 bits (189), Expect = 1e-13
Identities = 133/575 (23%), Positives = 212/575 (36%), Gaps = 110/575 (19%)
Query: 543 VFIQDAGNYTCY----AANTEGSLNASATLTVWNRTSI-VHPPEDHVVIKGTTATLHCGA 597
+ +++ +T Y AA T L S+ L + S+ + PP++ +I T+
Sbjct: 1204 IILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD------ 1257
Query: 598 THDPRVSLRYVWKKDNVALTPSSTSRI----VVEKDGSLLISQTWSG-----------DI 642
+VW K + + P ++ + E + + + SG +
Sbjct: 1258 ---------FVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPV 1308
Query: 643 GDYSCEI-----VSEGGNDSRMARLEVIE-LPHSPQNLLVSPNSSHSHAVVLSWVRPFDG 696
YS + V G S + + E +P QN+ S S V++ W P
Sbjct: 1309 STYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS--VLVKWDPPKKA 1366
Query: 697 NSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSA 756
N I Y+V + N++ V P+ T L +Y F+V A G G S
Sbjct: 1367 NGIITQYMVTVERNST-------KVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDEST 1419
Query: 757 ETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE 816
LPE PS P NI S + S + W P + GY Y++
Sbjct: 1420 -CHVSTLPETVPSVPT-NIAFSDVQSTSATLTWIRPD------TILGYFQNYKITTQLRA 1471
Query: 817 YQQRNITSPE------VNYCLVTDLIIWTQYEI--------QVAAYNGAGLGVFSRAVTE 862
+ + S E + Y L T Y + QVAA AG G S ++
Sbjct: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWIST 1531
Query: 863 YTLQGVPTAPPQNVQTEAVNSTTIQFLWNPP-----PQQF---INGINQGYKLLAWPADA 914
TL G P PP+NV A + +I W+ P P + + ++ +++
Sbjct: 1532 KTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSN 1591
Query: 915 PEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFT-----TPGDGPPSTPQLVWTQE 969
E T+ I +L+ FT Y + FT +G S +V T E
Sbjct: 1592 EENKTI-------------EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLE 1638
Query: 970 DKP-GAVGHLSFTEILD--TSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLN-- 1024
P +++F +I D T ++++ P + NG I YQ VY +D N
Sbjct: 1639 SAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL--VYREDDPTAVQIHNLS 1696
Query: 1025 --STTHEYKI---QGLSSLTTYTIDVAAVTAVGTG 1054
T+ + I +GL TY I V AV + G G
Sbjct: 1697 IIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAG 1731
Score = 48.9 bits (115), Expect = 5e-05
Identities = 49/197 (24%), Positives = 82/197 (41%), Gaps = 10/197 (5%)
Query: 1760 EPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLN 1819
E V + N+ T+Y ++IS+ + P + + T+ PG P FLA + S +
Sbjct: 16 ETQVDVSNVVPGTRYDITISSISTTYTSPVT--RIVTTNVTKPGPPVFLAGERVGSAGIL 73
Query: 1820 VSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRW-LKVRDLTKGVTYFFR 1878
+SW P NG + Y V Y+ + P + V +VR + + +L G TY +
Sbjct: 74 LSWNTPPNPNGRIISYIVKYKEVCPWM---QTVYTQVRSKPDSLEVLLTNLNPGTTYEIK 130
Query: 1879 VQARTITYGPELQANITAGPAEGSPGSPRDVLV-TKSASELTLQWTEGHSGDTPTTGYVI 1937
V A AE +PG ++ V +AS + L W + T + I
Sbjct: 131 VAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI 190
Query: 1938 EARPSDEGLWDMFVKDI 1954
+ + G+ VKD+
Sbjct: 191 SVKHARSGI---VVKDV 204
Score = 35.0 bits (79), Expect = 0.82
Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 7/145 (4%)
Query: 1858 GNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE 1917
G + + V ++ G Y + + + TY + +T + PG P + + S
Sbjct: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTK--PGPPVFLAGERVGSA 70
Query: 1918 -LTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976
+ L W + + Y+++ + + ++ + + S + L L G TYE
Sbjct: 71 GILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQ-VRSKPDSLEVLLTNLNPGTTYEI 129
Query: 1977 RVVAVNEAGYGEPSNP---STAVSA 1998
+V A N AG G S+P TA SA
Sbjct: 130 KVAAENSAGIGVFSDPFLFQTAESA 154
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,480,035
Number of Sequences: 37866
Number of extensions: 4953813
Number of successful extensions: 37549
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 364
Number of HSP's successfully gapped in prelim test: 716
Number of HSP's that attempted gapping in prelim test: 18721
Number of HSP's gapped (non-prelim): 8738
length of query: 2213
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2095
effective length of database: 13,779,330
effective search space: 28867696350
effective search space used: 28867696350
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.