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Search of human proteins with 118918423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118918423 hypothetical protein LOC286207 [Homo sapiens]
(520 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118918423 hypothetical protein LOC286207 [Homo sapiens] 1014 0.0
gi|221219020 NYD-SP11 protein [Homo sapiens] 77 3e-14
gi|45439327 periplakin [Homo sapiens] 71 2e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 3e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 70 4e-12
gi|166295204 hypothetical protein LOC80127 [Homo sapiens] 69 8e-12
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 69 1e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 4e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 67 4e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 67 5e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 67 5e-11
gi|221139761 zinc finger protein 853 [Homo sapiens] 65 1e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 65 1e-10
gi|148746195 trichohyalin [Homo sapiens] 65 1e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 1e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 64 3e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 64 3e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 64 3e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 64 3e-10
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 64 4e-10
gi|153791839 sodium channel associated protein 1 [Homo sapiens] 64 4e-10
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 63 7e-10
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 62 1e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 62 1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 1e-09
gi|109134347 NY-REN-58 antigen [Homo sapiens] 62 1e-09
gi|109134355 NY-REN-58 antigen [Homo sapiens] 62 1e-09
gi|4758650 kinesin family member 5C [Homo sapiens] 62 2e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 62 2e-09
gi|33946313 ninein isoform 4 [Homo sapiens] 62 2e-09
>gi|118918423 hypothetical protein LOC286207 [Homo sapiens]
Length = 520
Score = 1014 bits (2623), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD 60
MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD
Sbjct: 1 MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD 60
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE
Sbjct: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
Query: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR
Sbjct: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
Query: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR
Sbjct: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
Query: 241 VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD 300
VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD
Sbjct: 241 VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD 300
Query: 301 TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR 360
TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR
Sbjct: 301 TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR 360
Query: 361 ASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA 420
ASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA
Sbjct: 361 ASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA 420
Query: 421 CPHQESQSHGPPKESRPSIQLPRTGSLLPQLSDITPYQPGDLGLVPRQVHIPPNPQDLRL 480
CPHQESQSHGPPKESRPSIQLPRTGSLLPQLSDITPYQPGDLGLVPRQVHIPPNPQDLRL
Sbjct: 421 CPHQESQSHGPPKESRPSIQLPRTGSLLPQLSDITPYQPGDLGLVPRQVHIPPNPQDLRL 480
Query: 481 LSYITRVGTFRAHSSPEMRAPGSLKRLEKFSLPEVPLRPK 520
LSYITRVGTFRAHSSPEMRAPGSLKRLEKFSLPEVPLRPK
Sbjct: 481 LSYITRVGTFRAHSSPEMRAPGSLKRLEKFSLPEVPLRPK 520
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 77.4 bits (189), Expect = 3e-14
Identities = 97/422 (22%), Positives = 194/422 (45%), Gaps = 68/422 (16%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQI------RDLEDRLARYQR 57
K++ ++ + E +K ++E + E LA+E ++ + R++ ++ +
Sbjct: 1580 KRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
Query: 58 KWDELAVQEKMFRQEFEQLANNKKEI--------------------VAFLKRTLNQQVDE 97
K + LA + + QE E+LA +K++ +A +K L Q+V+E
Sbjct: 1640 KEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEE 1699
Query: 98 ITDLNEQL--QNLQLAKEMEKDAFEAQ-LAQVRHEFQETKDQLTTENIILGGKLAALEE- 153
+ + L Q +LA+E+E+ ++ + L+ E + + +L E KLA EE
Sbjct: 1700 LPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEK----KKLAEEEEA 1755
Query: 154 FRLQKEEVTDKFTLL--EEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANE 211
Q+E+++++ T L EE++ QE E A + EK +++RL ++ R L+ +
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKE--KLAQHKEKMPE-EEERLGRK---REQLIEKK 1809
Query: 212 FHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLEN 271
W + + +N I Q ++Q+ L QE E+L R+ NL E L +
Sbjct: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
Query: 272 TQK--VMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALK 329
++K V ++K G M K +L+Q+E++ Q + K
Sbjct: 1870 SKKQLVQVKNKLG------MFNK-----------------ILAQVEEKLTQEKETVIKKK 1906
Query: 330 SQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDV 389
+ + +L Q + L + Q++LA E K++ +LE A+VQ L+ L + ++E+ ++
Sbjct: 1907 EKLAETEKKLVQVEDSLAKKQEKLAQE-KMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
Query: 390 DV 391
++
Sbjct: 1966 EM 1967
Score = 61.2 bits (147), Expect = 2e-09
Identities = 86/359 (23%), Positives = 159/359 (44%), Gaps = 18/359 (5%)
Query: 11 GKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDL----EDRLARYQRKWDELAVQE 66
GK +E KKK ++E +A + E +E Q +L +++LA+++ K E +E
Sbjct: 1740 GKLVEEKKKLAEEEEALAWQREKLSE-EETKLAQEEELLIQEKEKLAQHKEKMPE---EE 1795
Query: 67 KMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQ-LAQ 125
+ ++ EQL K ++ +R +N + + Q LA+E + A E + LAQ
Sbjct: 1796 ERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQ 1855
Query: 126 VRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYN 185
+ K++LT L L F +V +K T +E V K++ + +
Sbjct: 1856 RKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE---- 1911
Query: 186 LEKKSVLDKDRLRKE---IIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVS 242
EKK V +D L K+ + Q +A E V + KE + L+M R++
Sbjct: 1912 TEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLA 1971
Query: 243 QQGMKLLQENEQL-KGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK-KCQEQQQD 300
++ M+L++ E L KG +Q ++ + Q++ R +KI+L + E+ +
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031
Query: 301 TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKV 359
K E Q +L ++ L +R+ LS + + L+ LQ+ +E+K+
Sbjct: 2032 AKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKL 2090
Score = 55.1 bits (131), Expect = 2e-07
Identities = 84/390 (21%), Positives = 167/390 (42%), Gaps = 46/390 (11%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFE 74
E ++ G K+E ++ + LA++ + + + ++++ YQ+K LA ++K QE E
Sbjct: 1794 EEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK--NLAQEKKNLAQEKE 1851
Query: 75 QLANNK------KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAF---EAQLAQ 125
+LA K KE + K+ L Q +++ N+ L ++ EK+ + +LA+
Sbjct: 1852 KLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE 1911
Query: 126 VRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEE-QVRKQENEFRDYAY 184
+ + +D L + L + L L+K V K L E + K+E A
Sbjct: 1912 TEKKLVQVEDSLAKKQEKLAQEKMKLA---LEKAMVQGKKRLRGELDIAKEEK-----AL 1963
Query: 185 NLEKKSVLDKDRLR----KEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
NLE K L ++++R KE + + + T E +R + I L R
Sbjct: 1964 NLEMKR-LAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDR 2022
Query: 241 VSQQGMKLLQENEQLKGR-------------QNNLCKQLELLENTQKVMARHKRGHQKII 287
+ ++E+E KG+ Q L K L ++ +++ KI+
Sbjct: 2023 ILA-----MEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKIL 2077
Query: 288 LMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLS---LQLEQQQV 344
L K +++++ T+E ++ + L + +L ++ L + S +L + +
Sbjct: 2078 KALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK 2137
Query: 345 DLQRLQQELANEQKVRASLEAALVQATSFL 374
L R Q++LAN+ + + E + + S L
Sbjct: 2138 KLARKQRKLANKMRRMINKEEKMTEEESKL 2167
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/252 (21%), Positives = 114/252 (45%), Gaps = 34/252 (13%)
Query: 141 NIILGGKLAALEEFRL------QKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDK 194
N+ +G +++ EE + Q + K + + R+ E RD + +E+ + L++
Sbjct: 1380 NVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEE 1439
Query: 195 DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAI---KENNGITLQMARVSQQGM--KLL 249
+++E + + W+ K+A K+ +G T + + ++ +LL
Sbjct: 1440 KVVKQE---------GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLL 1490
Query: 250 QENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQ----------- 298
QE E+L L + E+L+ +K+ + + Q ML+ K +EQQ
Sbjct: 1491 QEEEKLHQAGEKLSPEEEMLQEDKKL--KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEE 1548
Query: 299 QDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQK 358
+ ++E EE +++ EQR +Q + + +R + + Q++ L + +++LA E++
Sbjct: 1549 EVSREGEEKEQQVTE-EQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEER 1607
Query: 359 VRASLEAALVQA 370
A E L QA
Sbjct: 1608 QLAQEERKLAQA 1619
Score = 38.1 bits (87), Expect = 0.020
Identities = 51/255 (20%), Positives = 111/255 (43%), Gaps = 44/255 (17%)
Query: 33 LAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQE-KMFRQEFEQLANNKKE-------IV 84
L K+ K+ Q R L +++ R K +++ +E K+ R+ E + ++++E ++
Sbjct: 2132 LTKDEKKLARKQ-RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVI 2190
Query: 85 AFLKRT----------------LNQQVDEITDLNEQLQNLQ-LAKEMEKDAFEAQLAQVR 127
FLKR + QVDE+ + ++ L E+EK + +
Sbjct: 2191 PFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE 2250
Query: 128 HEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLE 187
E +E +++ EE R ++EE ++ E+QV K+E E + +
Sbjct: 2251 REEEEEREE---------------EEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
Query: 188 KKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMK 247
K+ V +K+ + +E + +++ E + ++ E +++E ++ + +Q
Sbjct: 2296 KEEVQEKEEVFEE---KEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKL 2352
Query: 248 LLQENEQLKGRQNNL 262
Q + L+GR+ L
Sbjct: 2353 QEQRRKSLRGRERVL 2367
Score = 31.6 bits (70), Expect = 1.8
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 9/91 (9%)
Query: 337 LQLEQQQVDLQRLQQELANEQKV-------RASLEAALVQATSFL-QNILQMHRDEEDS- 387
LQL Q+Q + +QQ++ E+ + L+ Q L +N+ HRDE+ +
Sbjct: 990 LQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENLTLSHRDEKPAF 1049
Query: 388 DVDVTFQPWHKEMLQQLLVMLSSTVATRPQK 418
+DV+ K L+ V S VA +P K
Sbjct: 1050 SLDVSMPSELKSSLKPPTVSEESEVAIKPSK 1080
Score = 30.8 bits (68), Expect = 3.1
Identities = 59/369 (15%), Positives = 160/369 (43%), Gaps = 45/369 (12%)
Query: 17 KKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQE---F 73
KK+ + + E L EMK ++R +E + + + E + Q KM + E F
Sbjct: 1947 KKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
Query: 74 EQLANNKKEIVAFLKRTLNQQVDEITDLN-EQLQNLQLAKEMEKDAFEAQLAQVRHEFQE 132
E+ + +++I+ R L + EI E + ++ + ++ +A ++
Sbjct: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESL 2066
Query: 133 TKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEE---------QVRKQENEFRDYA 183
+K+ I+ + +E +L +EE+ K T ++ + + + + +++
Sbjct: 2067 SKEPAKLNKILKALQKLTRDERKLTQEEI--KMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
Query: 184 YNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQ 243
++ EK+S L KD K++ ++ +AN+ +R I + +T + +++++
Sbjct: 2125 FS-EKRSELTKDE--KKLARKQRKLANKM------------RRMINKEEKMTEEESKLAR 2169
Query: 244 QGMKLLQENEQLKG-RQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQ----- 297
+ +++ ++E+ G + + L+ +K R + +K + + E+
Sbjct: 2170 KHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEE 2229
Query: 298 ---------QQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQR 348
+Q++ +EE + E+ +++ + + K + + Q+E+++ + ++
Sbjct: 2230 MESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKK 2289
Query: 349 LQQELANEQ 357
++E E+
Sbjct: 2290 KKKEKKKEE 2298
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 71.2 bits (173), Expect = 2e-12
Identities = 92/399 (23%), Positives = 175/399 (43%), Gaps = 62/399 (15%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEIT----------DLNEQLQNLQ- 109
EL QE+ +R EQL + + E+ A +R +V E+T ++ ++LQ L+
Sbjct: 1194 ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLRE 1253
Query: 110 --LAKEMEKDAFEAQLAQVRHEFQ---ETKDQLTTENIILGGKLAALEEFRLQKEEVTDK 164
+ K + + ++ Q++ E Q +TK Q+ T+ ++ ++ +E KEEV
Sbjct: 1254 EIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVV--QEILQFQEDPQTKEEVASL 1311
Query: 165 FTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETT 224
L E+ +KQ + R+ A +++ + K+ + +RV V E +
Sbjct: 1312 RAKLSEEQKKQVDLERERA--SQEEQIARKEEELSRVKERV--VQQEVVRYEEEPGLRAE 1367
Query: 225 KRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQ 284
A E+ + L +Q KL E +L+ R+ L +QLE LE ++ +R Q
Sbjct: 1368 ASAFAESIDVEL------RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421
Query: 285 KIILMLTKKCQEQ---------------QQDTKEAEELRLLLSQLEQRSLQLQVDNQALK 329
++ L QE+ QQD ++A E LL QLE+ + Q+ L+
Sbjct: 1422 RLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELE 1481
Query: 330 SQRDQL----------------SLQLEQ--QQVDLQRLQQELANEQKVRASLEAALVQAT 371
+ R +L S+Q+E+ + ++QRL+ L E + + L+ + +
Sbjct: 1482 TLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLE 1541
Query: 372 SFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSS 410
+ L L+ H + ++D + HK L++ + L +
Sbjct: 1542 ARLSE-LEFHNSKSSKELDFLREENHKLQLERQNLQLET 1579
Score = 50.4 bits (119), Expect = 4e-06
Identities = 72/344 (20%), Positives = 158/344 (45%), Gaps = 57/344 (16%)
Query: 14 LEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELA-VQEKMFRQE 72
L+ ++ KE V ++ L++E K+ ++ R+ + + RK +EL+ V+E++ +QE
Sbjct: 1296 LQFQEDPQTKEEVASLRAKLSEEQKKQVDLE-RERASQEEQIARKEEELSRVKERVVQQE 1354
Query: 73 ---FEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHE 129
+E+ + E AF + +++ ++ +I L +L+ LQ + E QL ++ E
Sbjct: 1355 VVRYEEEPGLRAEASAFAE-SIDVELRQIDKLRAELRRLQ----RRRTELERQLEELERE 1409
Query: 130 FQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKK 189
++ + + E L +LAALE+ ++ E +K T ++ V +Q
Sbjct: 1410 -RQARREAEREVQRLQQRLAALEQ---EEAEAREKVTHTQKVVLQQ-------------- 1451
Query: 190 SVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLL 249
D + R+ + R+ L + + ET +R + L+ A V ++ +L
Sbjct: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLA-----ALEKAEVKEK--VVL 1501
Query: 250 QENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL 309
E+ Q++ + + ++++ L+++ + +R KR + E L
Sbjct: 1502 SESVQVE--KGDTEQEIQRLKSSLEEESRSKR-----------------ELDVEVSRLEA 1542
Query: 310 LLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL 353
LS+LE + + + L+ + +L L+ + Q++ +RLQ E+
Sbjct: 1543 RLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEI 1586
Score = 43.1 bits (100), Expect = 6e-04
Identities = 71/308 (23%), Positives = 138/308 (44%), Gaps = 53/308 (17%)
Query: 97 EITDLNEQ-LQNLQLAKEMEKDAFEAQLAQVRHE-FQETKDQLTTENIILGGKLAALEEF 154
E+ +N Q LQNL+ A + + E + V HE Q + E E +
Sbjct: 848 EVYAINRQRLQNLEFALNLLRQQPEVE---VTHETLQRNRPDSGVE-----------EAW 893
Query: 155 RLQKE--EVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVN--LVAN 210
+++KE E T++ LE +V+ + E ++SV+ RKE++++V ++
Sbjct: 894 KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVV-----RKEVLKKVPDPVLEE 948
Query: 211 EFHKVTTNRMWETTKRAI--KENNGITLQMARVSQQGMK-----LLQENEQLKGRQNNLC 263
F ++ E K + +E + LQ+ + Q+ +++E +++ +
Sbjct: 949 SFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQAD 1008
Query: 264 KQLELLENTQKVMARHKRGHQKIILMLTKKC-------QEQQQDTKEAEELRLLLS-QLE 315
+ L+L E + + R K + +L+L ++ Q+ E E ++L QLE
Sbjct: 1009 EVLQLREELE-ALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLE 1067
Query: 316 QRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQ 375
QLQ D+Q ++DQL E+Q+ +L LQ +L +K RA E + ++
Sbjct: 1068 AEYQQLQEDHQ----RQDQLR---EKQEEELSFLQDKLKRLEKERAMAEGKIT-----VK 1115
Query: 376 NILQMHRD 383
+L++ +D
Sbjct: 1116 EVLKVEKD 1123
Score = 34.7 bits (78), Expect = 0.22
Identities = 79/406 (19%), Positives = 156/406 (38%), Gaps = 82/406 (20%)
Query: 47 DLEDRLAR-YQRKWDELAVQEKMFRQ-----EFEQLANNKKEIVAFLKRTLNQQVDEITD 100
D+ +RL + Q+ W+ LA E Q E ++ ++K + +A + L Q
Sbjct: 612 DVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSL--- 668
Query: 101 LNEQLQNLQLAKEMEK-------------DAFEAQLAQVRHEFQETKDQLTTENIILGGK 147
L E QNLQ AK+ + EA++ ++ F + Q+ L
Sbjct: 669 LGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSA 728
Query: 148 LAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLE-KKSVLDKDRLRKEIIQRVN 206
AA E F + V + ++ + L+ +K++LD+ R++ +Q++
Sbjct: 729 KAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKIC 788
Query: 207 LVANEFHKVTTNRMWETTK-RAIKE-NNGITLQM---ARVSQQGMKLLQENEQLKGR--- 258
+ ++ + + E K R++ + NG + + AR+ K+ +E L +
Sbjct: 789 ANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTE 848
Query: 259 ---------QN-----NLCKQLELLENTQKVMARHKRGH--------QKIILMLTKKCQE 296
QN NL +Q +E T + + R++ +K + T++ ++
Sbjct: 849 VYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQ 908
Query: 297 QQQDTKEAEE---------------------------LRLLLSQLEQRSLQLQVDNQALK 329
+ + K +E L QL++ + Q NQ L+
Sbjct: 909 LENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQ 968
Query: 330 SQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQ 375
+ + L LQL + + + QE ++ +R +E QA LQ
Sbjct: 969 EELEALQLQLRALEQETRDGGQEYVVKEVLR--IEPDRAQADEVLQ 1012
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 3e-12
Identities = 109/462 (23%), Positives = 182/462 (39%), Gaps = 77/462 (16%)
Query: 34 AKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQL-------------ANNK 80
A+E +RD+++ Q+K E Q++ + EQL A +
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
Query: 81 KEIVAFLKRTLNQQVDEI----TDLNEQLQNLQLAKE-MEKDAFEAQLAQVRHEFQETKD 135
KE + K L ++ + DL EQLQ L AKE +E FEAQ Q + TK
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ--QQNSVIEVTKG 788
Query: 136 QL-------TTENIILGGKLAA----LEEFRLQKEEVTDKF------------TLLEEQV 172
QL T ++ G++ L+ R Q E+ D T LE+Q
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
Query: 173 RKQENEFRDYAYNLEK----------KSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWE 222
E E EK K++ +R + E+ R+ E + R E
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE 908
Query: 223 TTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRG 282
T + + + ++ + LL+ Q + + +QLE L KV K
Sbjct: 909 RT----QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV---QKLK 961
Query: 283 HQKIILMLTKKCQEQQQDTKE-AEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQ 341
Q+ +L + QE Q++ KE A + R L+ L++ S L D L+ Q + L QL
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
Query: 342 QQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEML 401
Q + ++QE+ ++K+R + E +Q ++ E +T KE
Sbjct: 1022 QDDSQRLVEQEV--QEKLRETQEYNRIQ------------KELEREKASLTLSLMEKE-- 1065
Query: 402 QQLLVMLSSTVATRPQKAACPHQESQSHGPPKESRPSIQLPR 443
Q+LLV+ + + + +A ++ G KE ++L R
Sbjct: 1066 QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR 1107
Score = 69.3 bits (168), Expect = 8e-12
Identities = 79/304 (25%), Positives = 138/304 (45%), Gaps = 42/304 (13%)
Query: 81 KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTE 140
+E +A L +TL ++ +E+ L Q+Q L+ +EM+K A E ++ QE L E
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV--DLQQE 1477
Query: 141 NI-ILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRK 199
I L + LE + +E K T+ EQ+R+ E + R+ N+ + +L+ ++
Sbjct: 1478 QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLLELEK--- 1533
Query: 200 EIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKL-LQENEQLKGR 258
++M E+ + +++ L+ V+ + + L L+EN
Sbjct: 1534 -----------------KDQMIESQRGQVQD-----LKKQLVTLECLALELEENHHKMEC 1571
Query: 259 QNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRS 318
Q L K+LE TQ+V H + L L ++ QE Q + + +L S +
Sbjct: 1572 QQKLIKELEGQRETQRVALTH------LTLDLEERSQELQAQSSQIHDLE---SHSTVLA 1622
Query: 319 LQLQVDNQALKSQRDQ---LSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQ 375
+LQ +Q +KSQR+Q L Q E DL+R QEL +++ LE + T L+
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE 1682
Query: 376 NILQ 379
L+
Sbjct: 1683 EDLE 1686
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/388 (20%), Positives = 175/388 (45%), Gaps = 43/388 (11%)
Query: 22 KKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKK 81
++E + V+ +E+++ Q LE +L ++K ++M + Q+ + KK
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK-------DQMIESQRGQVQDLKK 1550
Query: 82 EIVAF--LKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTT 139
++V L L + ++ + ++ L+ +E ++ A + QE + Q +
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 140 ENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQEN-----EFRDYAYNLEKK--SVL 192
+ + E + + +EV + +EE R++E+ E RD L+K+ VL
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 193 DKDRLRK-----EIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMK 247
+ R R+ E ++++ L E + T + +RA + Q + +
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 248 LLQENEQLKGRQNNLCKQLELLENT-QKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
L + ++++ +Q ++ + EL + Q++ H++ + +L+ ++ +E
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLL-----------SQREQE 1779
Query: 307 LRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQE----LANEQKVRA- 361
+ +L QL++ Q ++ Q+L+SQ D+ L Q+ +L+ LQQE E++V+
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
Query: 362 --SLEAALVQATSFLQ---NILQMHRDE 384
+L+ AL QA L+ LQ H+++
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQ 1867
Score = 60.5 bits (145), Expect = 4e-09
Identities = 91/425 (21%), Positives = 173/425 (40%), Gaps = 96/425 (22%)
Query: 52 LARYQRKWDELAVQEKMFRQEFEQLA------NNKKEIVAFLKRTLNQQVDEITDLNEQL 105
LAR ++ EL+ E + E L + E +A K LNQQ+ ++ + N+ +
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
Query: 106 QNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKL-----------AALEEF 154
+ A E ++A + LA E ++ ++ L +N L +L A L +
Sbjct: 630 CSRMEAAEQARNALQVDLA----EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 155 RLQKEEVTDKF-----------TLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEI-I 202
+ +KEE+ K T LE+ ++ + + A +++K L +++ E+ +
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRL 745
Query: 203 QRVN-------------------LVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQ 243
Q V L ++ F N + E TK ++ Q V Q
Sbjct: 746 QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 244 QGMKLLQ-----ENEQLKGRQNNLCKQLELLENTQKV-MARHKRGHQKIILMLTKKCQE- 296
++ L+ E Q + ++ +QL E K + + K H+K + L +K ++
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865
Query: 297 ----QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRD-----------QLSLQLEQ 341
QQ+ K E L +LE R + Q + +A+++QR+ Q+ L+ E+
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925
Query: 342 QQV------------------DLQRLQQEL----ANEQKVRASLEAALVQATSFLQNILQ 379
++V L+RL+Q++ EQ+ L+ L +A L+ +
Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 380 MHRDE 384
HRD+
Sbjct: 986 QHRDD 990
Score = 59.3 bits (142), Expect = 8e-09
Identities = 83/378 (21%), Positives = 169/378 (44%), Gaps = 44/378 (11%)
Query: 2 APKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
A +K V++ ++ E ++ ++E A+E ++M+ ++ + E + QR+ +
Sbjct: 850 AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEER 909
Query: 62 LAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEA 121
+ + + + E +KE V+ L+ TL Q E+ D ++QL+ L+ +++K +
Sbjct: 910 TQAESALCQMQLE----TEKERVSLLE-TLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
Query: 122 QLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRD 181
++ + QE + +L LAAL+E + +LL++++ Q+ + D
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQE---------ESSSLLQDKMDLQK-QVED 1014
Query: 182 YAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAI----KENNGITLQ 237
L + D RL ++ +Q E++++ E + KE + LQ
Sbjct: 1015 LKSQLVAQD--DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
Query: 238 MA-RVSQQGMKLL-QENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQ 295
A + QQ + L Q+ ++ +G Q L Q+ELL K K+
Sbjct: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK----------------EKEAD 1116
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELAN 355
Q+ + EEL S + ++ L+ + Q K+ + QL L+ + Q++ +Q+ N
Sbjct: 1117 FLAQEAQLLEELE--ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
Query: 356 EQKVR---ASLEAALVQA 370
+ + + ASL +AL QA
Sbjct: 1175 QAQAQAQLASLYSALQQA 1192
Score = 56.2 bits (134), Expect = 7e-08
Identities = 88/419 (21%), Positives = 187/419 (44%), Gaps = 30/419 (7%)
Query: 23 KEPVVAVEPPLAKEMKEFYHIQ------IRDLEDRLARYQRKWDELAVQEKMFRQEFEQL 76
K+ +V +E LA E++E +H I++LE + + L + + QE +
Sbjct: 1549 KKQLVTLEC-LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 77 ANNKKEIVAF---LKRTLNQQVDEITDLNEQLQNLQLAKE---MEKDAFEAQLAQVRHEF 130
++ ++ + L R L ++ E+ EQ++ LQ KE + + + +L +
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI 1667
Query: 131 QETKDQLTTENIILGGKLAALE-EFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKK 189
Q +DQ T + IL L ++ R + E+T + L++E+ + + + +LE
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727
Query: 190 SVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR---VSQQGM 246
++ +D+ ++ Q+ ++ + K + + R + E + + Q + V QQ +
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787
Query: 247 KLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
+ +E +LK + +L QL+ Q+ +A+ Q++ + ++ Q Q Q+ + E+
Sbjct: 1788 QEAREQGELK--EQSLQSQLD---EAQRALAQRD---QELEALQQEQQQAQGQEERVKEK 1839
Query: 307 LRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVD---LQRLQQELANEQKVRASL 363
L LEQ + L+ + L+ ++Q E+ V+ +Q L++ L + +
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
Query: 364 EAALVQATSFLQNILQMHRDEEDS--DVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA 420
E AL+ Q H E + D + Q KE Q+L + + + ++R Q+ A
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958
Score = 51.6 bits (122), Expect = 2e-06
Identities = 86/431 (19%), Positives = 166/431 (38%), Gaps = 51/431 (11%)
Query: 35 KEMKEFYHIQIRDLEDRLARYQRKW--DELAVQEKMFRQEFEQLANNKKEIVAFLKRTLN 92
++ K + ++ L ++ + +R W ELA + +E +L KE ++
Sbjct: 845 EQQKAAHEKEVNQLREKWEK-ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 93 QQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE 152
Q+ +E T L +QL E E+ + L Q + E + QL +
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLR----------Q 953
Query: 153 EFRLQKEEVTDKFTLLEEQVRKQENEFRDYA---------YNLEKKSVL-DKDRLRKEII 202
+ ++QK + + +L+ Q+++ + E ++ A E S+L DK L+K++
Sbjct: 954 DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013
Query: 203 Q-RVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNN 261
+ LVA + + + + R +E N I ++ R L E EQ
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ------- 1066
Query: 262 LCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQL 321
+L +L+ + Q+ + L + QE Q + KE L +Q+E ++
Sbjct: 1067 ---RLLVLQEADSI-------RQQELSALRQDMQEAQGEQKE------LSAQMELLRQEV 1110
Query: 322 QVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMH 381
+ +Q QL +LE + Q+L+ L ++ A L+ L S L+ +
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
Query: 382 RDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGPPKESRPSIQL 441
+ + + + Q L S +RP+ + G + + L
Sbjct: 1171 QPGNQAQAQAQLASLYSALQQ----ALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL 1226
Query: 442 PRTGSLLPQLS 452
+ G LL LS
Sbjct: 1227 FKRGPLLTALS 1237
Score = 50.4 bits (119), Expect = 4e-06
Identities = 80/354 (22%), Positives = 149/354 (42%), Gaps = 33/354 (9%)
Query: 71 QEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEF 130
QE E+ A+ + + + LK + + E+ D +L L + + + +E + +R
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR--- 310
Query: 131 QETKDQLTTENIILGGKLAAL----EEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNL 186
ET + L T + L A+L +E +L ++V T QV +E +
Sbjct: 311 -ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT----QVMVEEGDNIAQGSGH 365
Query: 187 EKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGM 246
E LD + Q + V T R ++A+++ + Q+A +
Sbjct: 366 ENSLELDSSIFSQFDYQDADKALTLVRSVLTRR-----RQAVQD---LRQQLAGCQEAVN 417
Query: 247 KLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
L Q+++Q + L ++L+ L + +A Q + L+K E++ K EE
Sbjct: 418 LLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK---ERELLQKAREE 474
Query: 307 LRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAA 366
LR L LEQ + +L+ N L+ Q D Q E+QQ +L +E Q++ LEA
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA- 533
Query: 367 LVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA 420
+ + L ++ + E S ++ E+L+Q +++ +A Q A
Sbjct: 534 --KQSESLSELITLREALESSHLE-------GELLRQEQTEVTAALARAEQSIA 578
Score = 48.9 bits (115), Expect = 1e-05
Identities = 83/387 (21%), Positives = 170/387 (43%), Gaps = 38/387 (9%)
Query: 33 LAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLN 92
L + +K+ + + + D +A+ + L + +F Q Q A+ +V + L
Sbjct: 341 LQQVIKDITQVMVEE-GDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLV---RSVLT 396
Query: 93 QQVDEITDLNEQLQNLQLAKEM---EKDAFEAQLAQVRHEFQET---KDQLTTENIILGG 146
++ + DL +QL Q A + + D +E + +R Q+ +D L + + L G
Sbjct: 397 RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Query: 147 KLAALEEFR--LQK--EEVTDKFTLLEEQ---VRKQENEFR---DYAYNLEKK------- 189
++ +L + R LQK EE+ + +LE++ +R+ E + D A +++
Sbjct: 457 EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
Query: 190 SVLDKDRLRKEIIQRVNLVANEF--HKVTTNRMWETT----KRAIKENNGITLQMARVSQ 243
+V +++RL+ E++ + +E +T E++ + +E +T +AR Q
Sbjct: 517 AVRERERLQ-EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 244 QGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKE 303
+L LK +L L + +A K G + +L L ++ Q +
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 304 AEE----LRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKV 359
AE+ L++ L++ E+R L N L++Q + + Q DL+ +Q+E QK
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 360 RASLEAALVQATSFLQNILQMHRDEED 386
+ AT+ L+ + Q + +E+
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEE 722
Score = 47.0 bits (110), Expect = 4e-05
Identities = 88/406 (21%), Positives = 164/406 (40%), Gaps = 60/406 (14%)
Query: 35 KEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQ 94
++ ++ Q++ LE+RL + + ++ + + +++ Q K + + N
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK----WEGKQNSL 1311
Query: 95 VDEITDLNEQLQNLQLA-KEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEE 153
E+ +L+E + +LQ + E EAQ R Q K+ LT + L AA+ E
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQ--GERELLQAAKENLTAQVEHLQ---AAVVE 1366
Query: 154 FRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFH 213
R Q +LEE +R + + K ++ +R R + +Q +
Sbjct: 1367 ARAQASAAG----ILEEDLRTARSALK------LKNEEVESERERAQALQEQGEL----- 1411
Query: 214 KVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQ 273
KV + A++EN +A ++Q + +E E L+G+ L KQ E+
Sbjct: 1412 KVAQGK-------ALQEN------LALLTQTLAEREEEVETLRGQIQELEKQREM----- 1453
Query: 274 KVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRD 333
K + + L L K+ QE ++ +EL S LE + +Q Q L QR+
Sbjct: 1454 -----QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 334 QL-SLQ---------LEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRD 383
Q+ L+ LE Q ++L++ Q + +++ L+ LV + + H
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
Query: 384 EEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSH 429
E + +E + L L+ + R Q+ Q SQ H
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA--QSSQIH 1612
Score = 46.2 bits (108), Expect = 7e-05
Identities = 89/410 (21%), Positives = 166/410 (40%), Gaps = 76/410 (18%)
Query: 34 AKEMKEFYHIQIRDLEDRLARYQRKWDELAV------QEKMFRQEFEQL-----ANNKKE 82
+++++E IQ +++D+ RYQ +L +E +QE EQL A +E
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQE 2071
Query: 83 IVAFLKRTLNQQ--VDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTE 140
+ K+ L Q+ +EI L++ ++ LQL AQ Q E +ET+ + E
Sbjct: 2072 NMIQEKQNLGQEREEEEIRGLHQSVRELQLTL--------AQKEQEILELRETQQRNNLE 2123
Query: 141 NIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKE 200
+ K + +EE L K LE +++++ + E + + +++ +
Sbjct: 2124 ALPHSHKTSPMEEQSL-------KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDL 2176
Query: 201 IIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQN 260
+ TK ++ +LQ + Q L +++EQ +
Sbjct: 2177 ALSLAQ-----------------TKASVS-----SLQEVAMFLQASVLERDSEQQR---- 2210
Query: 261 NLCKQLELLENTQKVMARHK-----------RGHQKIILMLTKKCQ-EQQQDTKEAEELR 308
L +LEL + H RG Q + L + E D E + R
Sbjct: 2211 -LQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269
Query: 309 LLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALV 368
L L+Q +L++D L+ QL LEQ + + ++L++E A SLE +
Sbjct: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKRE-AMRAAQAGSLEISKA 2328
Query: 369 QATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQK 418
A+S Q Q R +++SD E+ ++++++ + R QK
Sbjct: 2329 TASSPTQ---QDGRGQKNSDAKCV-----AELQKEVVLLQAQLTLERKQK 2370
Score = 33.5 bits (75), Expect = 0.48
Identities = 76/394 (19%), Positives = 164/394 (41%), Gaps = 47/394 (11%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQ----LQNLQLAKEMEK 116
+L ++E++ + +Q+A N+ LK + Q + T + + LQ +E+EK
Sbjct: 17 QLVLEEQVLALQ-QQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEK 75
Query: 117 DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQE 176
EA + ++ ++ E ++ LEE + + E + + T L + K +
Sbjct: 76 -RLEATGGPIPQRWENVEEPNLDELLV------RLEEEQQRCESLAEVNTQLRLHMEKAD 128
Query: 177 NEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANE------FHKVTTNRMWETTKRAIKE 230
+ ++EK +V D R R E++++ + E + K R+ + +
Sbjct: 129 VVNKALREDVEKLTV-DWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 231 NNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHK---RGHQKII 287
+ + M+L E+ +L G C +L + +++ + R +++
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 288 LMLTKKCQEQQQDTKEAEELRLLLSQ--LEQRSLQLQVD----------------NQALK 329
L+L K + +++ + ++EL L SQ LE+ LQ +V + +K
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 330 SQRDQLSLQLEQQQVDLQRLQQELA-NEQKVRASLEAALVQATSFL----QNILQMHRDE 384
+ R+ + + LE +L + L+ N Q+ + SL+ + T + NI Q E
Sbjct: 308 ALRETVEI-LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 385 EDSDVDVT-FQPWHKEMLQQLLVMLSSTVATRPQ 417
++D + F + + + L ++ S + R Q
Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 70.5 bits (171), Expect = 4e-12
Identities = 90/393 (22%), Positives = 172/393 (43%), Gaps = 79/393 (20%)
Query: 34 AKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQ 93
AKE + Y +IR LE+ L +++ E + E E N + K+ L++
Sbjct: 862 AKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ-LSE 920
Query: 94 QVDEITDLNEQLQNLQ---------LAKEMEK---------DAFEAQLAQVRHEFQETKD 135
++ E ++ EQL+ L+ L K +EK +A +++++ E K+
Sbjct: 921 KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE 980
Query: 136 ----QLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQ--------------EN 177
+L L K E+ RL ++ D+ L+EE++R E
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQ 1040
Query: 178 EFRDYAYNLEKKSVL--DKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGIT 235
+D Y LE KS L D+ RL K++ +V+ + E + E N
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE---------------ERNNSD 1085
Query: 236 LQMARVSQQGMKLLQ-ENEQLK---GRQNNLCKQLELLENTQKVMAR-------HKRGHQ 284
L R+S+ ++ Q NE L+ RQ+ C ++ L + + +R ++ +
Sbjct: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
Query: 285 KIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQ-------LQVDNQ--ALKSQRDQL 335
+++ + + E + D E+EE QL R L+ +QVD++ +L Q+DQL
Sbjct: 1146 GLVVQMEARIAELE-DRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL 1204
Query: 336 SLQLEQQQVDLQRLQQEL----ANEQKVRASLE 364
SL+L+ + ++ ++E+ ++++K++ LE
Sbjct: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
Score = 63.2 bits (152), Expect = 6e-10
Identities = 81/370 (21%), Positives = 160/370 (43%), Gaps = 23/370 (6%)
Query: 36 EMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQV 95
E K I++ +L+ +L + + + + R E+L + E V TL Q++
Sbjct: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE-NSTLQQRL 672
Query: 96 DEIT-DLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEF 154
+E +L + L+ L K ME++ + ++ ++ + E D+L + + AL E
Sbjct: 673 EESEGELRKNLEELFQVK-MEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE 731
Query: 155 RLQ-KEEVTDKFTLLEEQ---VRKQENEFRDYAYNL-EKKSVLDK--DRLRKEIIQRVNL 207
LQ K+++ D EEQ +RK+E E L E+ S D+ D+L+++ +
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 208 VANEFHKVTTNRMWETTKRAIKENN--GITLQMARVSQQGMKLLQENEQLKGRQNNLCKQ 265
+ + T N ++ E + G +++ + ++ KL +E+L+ R L +Q
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 266 LELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLL-----------SQL 314
+E L+ + + ++ I L + +++ KEA R L SQ
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 315 EQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFL 374
Q QL + Q++QL + + + L + + QK A + A +T L
Sbjct: 912 TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLEL 971
Query: 375 QNILQMHRDE 384
QN L ++++
Sbjct: 972 QNQLDEYKEK 981
Score = 55.8 bits (133), Expect = 9e-08
Identities = 83/370 (22%), Positives = 170/370 (45%), Gaps = 51/370 (13%)
Query: 2 APKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
A ++SV +A K +EV +A +++ + ++++ L++ + Q + +E
Sbjct: 791 ALRESVEEATKNVEV----------LASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
Query: 62 LAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEA 121
L + +++ E L ++ A K TL + EI L E L + A++ EK+A A
Sbjct: 841 LERRVAQLQRQIEDLKGDE----AKAKETLKKYEGEIRQLEEALVH---ARKEEKEAVSA 893
Query: 122 QLAQVRHEFQETK---DQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENE 178
+ A + +E + + Q T E L KL KEE K EQ+R+ +NE
Sbjct: 894 RRA-LENELEAAQGNLSQTTQEQKQLSEKL---------KEESEQK-----EQLRRLKNE 938
Query: 179 FRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQM 238
+ ++L K ++L+KE+ V E + +T + + KE N ++
Sbjct: 939 MENERWHLGKTI----EKLQKEMADIV-----EASRTSTLEL-QNQLDEYKEKN--RREL 986
Query: 239 ARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQK--VMARHKRGHQKIILMLTKKCQE 296
A + +Q + E E+ + + ++ L+E + A+ + ++ +L T K E
Sbjct: 987 AEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
Query: 297 QQQDTKE--AEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELA 354
+ + K ++ L+ Q+E + QL+++ + ++ D LS ++ + + +++L+ EL
Sbjct: 1047 YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELL 1106
Query: 355 NEQKVRASLE 364
E+ R LE
Sbjct: 1107 QERAARQDLE 1116
Score = 53.5 bits (127), Expect = 5e-07
Identities = 79/364 (21%), Positives = 154/364 (42%), Gaps = 55/364 (15%)
Query: 35 KEMKEFYHIQIRDLEDRLARYQRKWD--------------ELAVQEK-------MFRQEF 73
K +E + +IRDL+D+L+ + D E +Q K + ++E
Sbjct: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
Query: 74 EQLANNKKEIVAFLKRTLNQQV----DEITDLNEQLQ-NLQLAKEMEKDAFEAQLAQVRH 128
E L ++ + LK L ++V E+ L EQ LQ +E ++A +
Sbjct: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809
Query: 129 EFQETKDQ---------LTTENIILGGKLAALE----EFRLQKEEVTDKFTLLEEQVRKQ 175
+DQ L EN L G+ LE + + Q E++ +E ++K
Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869
Query: 176 ENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGIT 235
E E R +++++ + KE + + NE N + +TT +E ++
Sbjct: 870 EGEIRQL-----EEALVHARKEEKEAVSARRALENELEAAQGN-LSQTT----QEQKQLS 919
Query: 236 LQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQ 295
++ S+Q +L + +++ + +L K +E L QK MA + L L +
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL---QKEMADIVEASRTSTLELQNQLD 976
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELAN 355
E ++ K EL + QL++++L+ + +D++ L +E++ D QR Q E
Sbjct: 977 EYKE--KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL-MEEELRDYQRAQDEALT 1033
Query: 356 EQKV 359
++++
Sbjct: 1034 KRQL 1037
Score = 37.4 bits (85), Expect = 0.033
Identities = 49/243 (20%), Positives = 99/243 (40%), Gaps = 31/243 (12%)
Query: 169 EEQVRKQENE--FRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTT--------- 217
++++ +Q NE + YN K+ D D K ++VNLV F K+ T
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATK---RKVNLV---FEKIQTLKSRAAGSA 596
Query: 218 ---NRMWETT---KRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELL-- 269
N+ +T K +++ + +T+++A + +Q ++ + +K + + LE L
Sbjct: 597 QGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS 656
Query: 270 ------ENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
E + R + ++ L + Q + + + E+R L QL + +L
Sbjct: 657 QHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 324 DNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRD 383
++ ++ L +L Q + DLQ L ++ + E L L+ + H
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 384 EED 386
E D
Sbjct: 777 EMD 779
>gi|166295204 hypothetical protein LOC80127 [Homo sapiens]
Length = 529
Score = 69.3 bits (168), Expect = 8e-12
Identities = 72/373 (19%), Positives = 166/373 (44%), Gaps = 19/373 (5%)
Query: 8 SKAGKELEVKKKGGKKEPVVAVEPPL---AKEMKEFYHIQIRDLEDRLARYQRKWDELAV 64
SK + + K KG + ++ + + AK + ++ E +Y+ LA
Sbjct: 3 SKGKDKKKGKSKGKDTKKLIKTDESVVDRAKANASLWEARLEVTELSRIKYRDTSRILAK 62
Query: 65 QEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLA 124
+ +++ ++ + ++++LK+ ++ + I L +QL + + EKD E +
Sbjct: 63 SNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYT 122
Query: 125 QVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAY 184
+ +E + Q E ++ +L A+ +F+ +K +V + L+E +R E ++
Sbjct: 123 RQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLR 182
Query: 185 NLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQ 244
LE + +K RL +E +++ ++A H ++ + + KEN+ + +A ++
Sbjct: 183 RLESRFFEEKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKENDYLQKALAYHLKE 242
Query: 245 GMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEA 304
L + +++L+ L Q E+ + K +KI+ ++ ++ Q Q K
Sbjct: 243 TDALQKNSQKLQESHTLLLHQKEINDLLVK---------EKIMQLVQQRSQIQTLQKKVV 293
Query: 305 E---ELRLLLSQLEQRSLQLQ----VDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQ 357
L + + E L+LQ ++NQA + + D+L L+ + ++ R+++ N
Sbjct: 294 NLETALSYMTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKDREMNRVKKLAKNIL 353
Query: 358 KVRASLEAALVQA 370
R +E + A
Sbjct: 354 DERTEVERFFLDA 366
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 68.9 bits (167), Expect = 1e-11
Identities = 85/416 (20%), Positives = 178/416 (42%), Gaps = 58/416 (13%)
Query: 13 ELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQE 72
E ++K+ G+ + A + + + + H Q + E++LA+ Q+K +L + + ++
Sbjct: 783 EADIKRSEGELQQASA-KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 841
Query: 73 FEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQE 132
++ KK++ L Q D + L +Q ++ + +E++L E ++
Sbjct: 842 VAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901
Query: 133 TKDQLT-TENI-------------ILGGKLAALEE-FRLQKEEVTDKFTLLEEQVRKQEN 177
TK L EN+ IL KL+A E+ + EE KF E+++ K +
Sbjct: 902 TKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961
Query: 178 EFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQ 237
+ ++ L+KK + + +L+KE+ N E +++ K+ N L+
Sbjct: 962 KAKEMQETLKKKLLDQEAKLKKEL---------------ENTALELSQKE-KQFNAKMLE 1005
Query: 238 MARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQ 297
MA+ + G+ ++ + + N +Q+E L H+R +I + KK +Q
Sbjct: 1006 MAQANSAGI-----SDAVSRLETNQKEQIESLTEV------HRRELNDVISIWEKKLNQQ 1054
Query: 298 QQDTKEAEELRLL-----LSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQE 352
++ +E E++L +++L+Q+ L + + + + L + +Q L LQ++
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQ 1114
Query: 353 LANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVML 408
L + S Q+ ++ E +VD+ LQ+ LV L
Sbjct: 1115 LKQKS----------AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
Score = 64.3 bits (155), Expect = 3e-10
Identities = 100/480 (20%), Positives = 205/480 (42%), Gaps = 78/480 (16%)
Query: 2 APKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLAR-YQRKWD 60
A + S+ +E E K K +K+ + AKEM+E ++ D E +L + +
Sbjct: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQK--AKEMQETLKKKLLDQEAKLKKELENTAL 990
Query: 61 ELAVQEKMFRQEFEQLANNKK----EIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEK 116
EL+ +EK F + ++A + V+ L+ +Q++ +T+++ + N ++ +K
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 117 DAFEAQLAQVRHEFQ-ETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQ 175
+A+ Q HE Q + K+Q E L K+ F +KEE+ + T L+E+ KQ
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAE---LKQKILL---FGCEKEEMNKEITWLKEEGVKQ 1104
Query: 176 ENEFRDYAYNLEKKSV----LDKDR-----------------------LRKEIIQRVNLV 208
+ + L++KS L +D L++++++ L
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 209 ANEFHKV--------TTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQN 260
+ KV TT+ +++ K + +++N + + ++ + +E+L + +
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN------KSLEDKSLEFKKLSEELAIQLD 1218
Query: 261 NLCKQLE-LLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLL-LSQLEQRS 318
CK+ E LLE + IL CQ + KEA ++ +S+LE +
Sbjct: 1219 ICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 319 LQLQVDNQALKSQRDQLSLQLEQQQ--------------VDLQRLQQELANEQKVRASLE 364
QL + L Q + QLE+++ + + LQ+E N+Q+ + E
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 365 AALVQATSFLQN----ILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA 420
+ + Q L + M + ++ V+++ + L L V L ++++ ++AA
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSL---SKQLTDLNVQLQNSISLSEKEAA 1395
Score = 60.1 bits (144), Expect = 5e-09
Identities = 73/375 (19%), Positives = 164/375 (43%), Gaps = 41/375 (10%)
Query: 44 QIRDLEDRLARYQRKWDELAVQEKMFRQEF---EQLANNKKEIVAFLKRTLNQQVDEITD 100
Q+ + E+++ + + L +++ ++E +Q A+ K+ + LK+ L++ ++ +T
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 101 LNEQLQ----------------NLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIIL 144
+ E+L+ N+QL + EA ++ +R ++ E K +L + L
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
Query: 145 GGKLAALEEFRLQK-EEVTDKFTLLEEQVRKQENEFRDY---------AYNLEKKSVLDK 194
K+ L + ++ E+V D E +K ++ F + L+ K +K
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
Query: 195 DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQ 254
D + + ++ F + + +K KE+N T + Q ++++ +
Sbjct: 1478 DEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET----ELKSQTARIMELEDH 1533
Query: 255 LKGRQNNLCKQLELLEN-TQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQ 313
+ + + E+L+N Q+ HK QK + + +E+ KEAEE L
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQK-LQHFQELGEEKDNRVKEAEEKIL---T 1589
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR-ASLEAALVQATS 372
LE + ++ + + K + + ++L ++ ++ +L+ L+ L +E + A L+ Q +
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIA 1649
Query: 373 FL--QNILQMHRDEE 385
+ Q + QM EE
Sbjct: 1650 AIKKQLLSQMEEKEE 1664
Score = 57.4 bits (137), Expect = 3e-08
Identities = 86/391 (21%), Positives = 176/391 (45%), Gaps = 53/391 (13%)
Query: 44 QIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNE 103
++R +E L+ Y+ K+ EL +M ++E KK++ L ++ ++ + I +L E
Sbjct: 142 RLRRMERSLSSYRGKYSELVTAYQMLQRE-------KKKLQGILSQSQDKSLRRIAELRE 194
Query: 104 QLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQ----KE 159
+LQ Q AK+ ++ F+A L E KDQ + +L +++ L++ RL+
Sbjct: 195 ELQMDQQAKKHLQEEFDASL--------EEKDQYIS---VLQTQVSLLKQ-RLRNGPMNV 242
Query: 160 EVTDKFTLLEEQVR---KQENEFRDYAYNLEK-KSVLDKDRLRKEIIQRVNLVANEFHKV 215
+V LE Q K+EN D +E SV + L++ + ++ NL+
Sbjct: 243 DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL------- 295
Query: 216 TTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLK----GRQNNLCKQLELLEN 271
R ET + ++ +T + + +Q + LQE E++K + L QL +N
Sbjct: 296 --KRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
Query: 272 TQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQ 331
+ + + K +++ TK+ + + KE E ++QL R Q+ + L+ Q
Sbjct: 354 LIEQLEQDK----GMVIAETKRQMHETLEMKEEE-----IAQLRSRIKQMTTQGEELREQ 404
Query: 332 RDQLS-LQLEQQQVDLQRLQQELANEQKVRASLEAAL--VQATSFLQNI-LQMHRDEEDS 387
+++ E+ + L Q+ +K++A ++ + ++ TS + I LQ
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQ 464
Query: 388 DVDVTFQPWHKEMLQQLLVMLSSTVATRPQK 418
+V + +E + +L + +A + Q+
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLHEKELARKEQE 495
Score = 54.7 bits (130), Expect = 2e-07
Identities = 78/368 (21%), Positives = 159/368 (43%), Gaps = 54/368 (14%)
Query: 18 KKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLA 77
++G KKE + + AKE + HI + E + ++K E++
Sbjct: 917 REGQKKEIEILTQKLSAKE--DSIHILNEEYETKFKNQEKK--------------MEKVK 960
Query: 78 NNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQE-TKDQ 136
KE+ LK+ L +D+ L ++L+N L ++ F A++ ++ D
Sbjct: 961 QKAKEMQETLKKKL---LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 137 LTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDR 196
++ ++ +L E + + E+ D ++ E+++ +Q E ++ + + + +K++
Sbjct: 1018 VSRLETNQKEQIESLTE--VHRRELNDVISIWEKKLNQQAEELQE----IHEIQLQEKEQ 1071
Query: 197 LRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKEN---NGITLQMARVSQQGMKLLQENE 253
E+ Q++ L E ++ W + +K++ N + Q+ + S L Q+
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITW-LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
Query: 254 QLKGRQNNLCKQLE--LLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKE-AEELRLL 310
+LK L L L ENT QEQ + K AEE +
Sbjct: 1131 KLKAHLEKLEVDLNKSLKENTF--------------------LQEQLVELKMLAEEDKRK 1170
Query: 311 LSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQA 370
+S+L + + Q+LKS ++ + LE + ++ ++L +ELA + + AL++A
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
Query: 371 -TSFLQNI 377
T+ L NI
Sbjct: 1231 KTNELINI 1238
Score = 51.2 bits (121), Expect = 2e-06
Identities = 70/374 (18%), Positives = 167/374 (44%), Gaps = 58/374 (15%)
Query: 44 QIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNE 103
++RDL+ Y+ + EL E + ++ N K++ L+ N+ EIT + E
Sbjct: 554 KLRDLQQEAETYRTRILEL---ESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
Query: 104 ----QLQNLQLAK--------EMEKDAFEAQLAQVRHEFQETKDQLTTE-NIILGGKLAA 150
+L++L+ + ++ K ++ ++ ++R + ++ K+ L + II +
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 151 LEEFRLQKEEV--TDKFTLLEE---------QVRKQENEFRDYAYNLEKKSVLDKDRLRK 199
+ E L+K +V T+ +L E ++ ++ + +D ++++ D +
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 200 EIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQ 259
Q+V+ + E H+V+ R T++A+K+ +++Q + L + ++ LK Q
Sbjct: 731 HHQQQVDSIIKE-HEVSIQR----TEKALKD---------QINQLELLLKERDKHLKEHQ 776
Query: 260 NNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSL 319
+ +EN + + R + Q+ L Q ++ + L+QL+Q+ L
Sbjct: 777 AH-------VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 320 QLQVDNQAL-------KSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATS 372
L+ + L ++Q+ + +L+ ++ +Q L Q+L +K + +E + T
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL---EKQNSEMEQKVKSLTQ 886
Query: 373 FLQNILQMHRDEED 386
++ L+ E++
Sbjct: 887 VYESKLEDGNKEQE 900
Score = 47.4 bits (111), Expect = 3e-05
Identities = 69/358 (19%), Positives = 161/358 (44%), Gaps = 47/358 (13%)
Query: 65 QEKMFRQEFEQLANNKKE--IVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQ 122
QE + ++ E + ++K++ ++ K L +Q+DE E++++L +A EK Q
Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA---EKTKLITQ 347
Query: 123 LAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTD------KFTLLEEQVRKQE 176
L ++ ++ + +I K E +++EE+ + T E++R+Q+
Sbjct: 348 LRDAKNLIEQLEQDKGM--VIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQK 405
Query: 177 NEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITL 236
+ A+ +K++ + + R L A ++ T K + +E +
Sbjct: 406 EKSERAAFEELEKALSTAQKTEEA---RRKLKAEMDEQIKT-----IEKTSEEERISLQQ 457
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
+++RV Q+ + +++++ + E K+ H++ + LTKK Q
Sbjct: 458 ELSRVKQEVVDVMKKSSE---------------EQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQ---ALKSQRDQLSLQLEQQQVDLQRLQQEL 353
++++ +E ++ L SQ E + + + Q AL+ Q L + + L+ LQQE
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 354 ANEQ----KVRASLEAALVQATSFLQNI---LQMHRDEEDSDVDVTFQPWHKEMLQQL 404
+ ++ +SLE +L + + +++ L+ +++ + ++ V + HK L+ L
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK-HKTELESL 619
Score = 44.7 bits (104), Expect = 2e-04
Identities = 72/321 (22%), Positives = 132/321 (41%), Gaps = 48/321 (14%)
Query: 10 AGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQE--- 66
AG E E +K G + +V ++ L KE ++LE Y ++ +E QE
Sbjct: 1933 AGAEREKQKLG---KEIVRLQKDLRMLRKEHQ----QELEILKKEYDQEREEKIKQEQED 1985
Query: 67 ---------KMFRQEFE-QLANNKKEIVAFLKRTLN--QQVD-EITDLNEQLQNLQLAKE 113
K +EF QLA ++E+ +K T+N Q+V+ E+ + +++ N L K
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
Query: 114 MEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVR 173
EKD + A+ E + +++ T A + + + Q EE+ K+ ++++
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAREEEMT---------AKVRDLQTQLEELQKKY---QQKLE 2093
Query: 174 KQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNG 233
++EN D +E ++ L + + +I L EF + N R K
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQ---KTTLISDSKLKEQEFREQIHN----LEDRLKKYEKN 2146
Query: 234 ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENT--QKVMARHKRGHQKIILMLT 291
+ +G L + L G + E L + +M R + K+I +
Sbjct: 2147 VYATTVGTPYKGGNLYHTDVSLFGEPT----EFEYLRKVLFEYMMGRETKTMAKVITTVL 2202
Query: 292 KKCQEQQQDTKEAEELRLLLS 312
K +Q Q E E+ RL+ +
Sbjct: 2203 KFPDDQTQKILEREDARLMFT 2223
Score = 43.5 bits (101), Expect = 5e-04
Identities = 86/426 (20%), Positives = 172/426 (40%), Gaps = 41/426 (9%)
Query: 26 VVAVEPPLAKEMKEFYHI---------QIRDLEDRL--------ARYQRKWDE--LAVQE 66
V +++ L + KE H+ +++ LEDRL A +RK ++ A+++
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653
Query: 67 KMFRQ---EFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQL 123
++ Q + EQ + ++ L L ++ E+ L E+L++++ ++ +
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 124 AQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR-DY 182
+ QE D K++ L+ +KE++ + +E+ E R Y
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 183 AYNLEKKSVLD-KDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQ-MAR 240
L K + K + +I + E +K + + + ++ +NN Q +
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833
Query: 241 VSQQGMKLLQENEQLKGRQNNLCKQLEL-LENTQKVMARHKRGHQKIILMLTKKCQE--- 296
V K LQE E C+ LE ++ + R K H+ + LT K ++
Sbjct: 1834 VFDDVQKTLQEKELT-------CQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA 1886
Query: 297 -QQQDTKEAEELRLLLSQLEQRSLQLQVDNQAL---KSQRDQLSLQLEQQQVDLQRLQQE 352
QQ D + + LL E++S V + L ++Q + L +L + + Q+L +E
Sbjct: 1887 LQQMDGRN-KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKE 1945
Query: 353 LANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTV 412
+ QK L Q L+ R+E+ + H L+QL+ ++ +
Sbjct: 1946 IVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQL 2005
Query: 413 ATRPQK 418
A + Q+
Sbjct: 2006 AQKEQE 2011
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.0 bits (162), Expect = 4e-11
Identities = 106/441 (24%), Positives = 177/441 (40%), Gaps = 75/441 (17%)
Query: 15 EVKKKGGKKEPVVAVEP--PLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQE 72
E K K ++E ++ + LAKE K LEDR+A + E E+ +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKL--------LEDRIAEFTTNLTE----EEEKSKS 1017
Query: 73 FEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQE 132
+L N + ++ L+ L ++ + +L + + L E + Q+A+++ + E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL----EGDSTDLSDQIAELQAQIAE 1073
Query: 133 TKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQV--------------RKQENE 178
K QL + L LA +EE QK K LE Q+ K E +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 179 FRDYAYNLEK---------KSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIK 229
RD LE S + LR + Q VN++ K T +T + I+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL-----KKTLEEEAKTHEAQIQ 1188
Query: 230 ENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQ-------KVMARHKRG 282
E + SQ +L ++ EQ K + NL K + LEN + KV+ + K
Sbjct: 1189 E------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 283 HQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDN-QALKSQRDQLSLQLEQ 341
+ + + QE Q E E +R L+ + LQ+++DN L SQ D S +L +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELAD-KVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 342 Q----QVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWH 397
+ LQ Q+ L E + + SL L Q + + +EE++
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA---------- 1351
Query: 398 KEMLQQLLVMLSSTVATRPQK 418
K L++ + L + VA +K
Sbjct: 1352 KHNLEKQIATLHAQVADMKKK 1372
Score = 56.6 bits (135), Expect = 5e-08
Identities = 77/308 (25%), Positives = 133/308 (43%), Gaps = 39/308 (12%)
Query: 91 LNQQVDEITDLNEQLQNL---QLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGK 147
+++Q +E+ E+L + QLA E E +Q+ E + ++QL E +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL---- 895
Query: 148 LAALEEFRLQKEEVTDKFTLLEE-----QVRKQENEFRDYAYNLEKKSVLD-----KDRL 197
A EE R + +T K LEE + R +E E R EKK + +++L
Sbjct: 896 CAEAEELRAR---LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 198 RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKG 257
+E R L + KVTT E + ++E I + Q KL +E + L+
Sbjct: 953 EEEESARQKL---QLEKVTT----EAKLKKLEEEQII------LEDQNCKLAKEKKLLED 999
Query: 258 RQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQR 317
R L E K +A+ K H+ +I L ++ + +++ +E E+ R +LE
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR---RKLEGD 1056
Query: 318 SLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNI 377
S L L++Q +L +QL +++ + LQ LA ++ A AL + I
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 378 LQMHRDEE 385
++ D E
Sbjct: 1114 SELQEDLE 1121
Score = 55.8 bits (133), Expect = 9e-08
Identities = 79/381 (20%), Positives = 166/381 (43%), Gaps = 28/381 (7%)
Query: 10 AGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMF 69
A KE E++ + E A + K+++E QI +L++ L + ++ Q++
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIREL-ESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 70 RQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDA--FEAQLAQVR 127
+E E L K E+ L T QQ E+ EQ N+ L K +E++A EAQ+ ++R
Sbjct: 1138 GEELEAL---KTELEDTLDSTAAQQ--ELRSKREQEVNI-LKKTLEEEAKTHEAQIQEMR 1191
Query: 128 HEF----QETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYA 183
+ +E +QL + A + ++ E+ ++ +L + E++ +
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 184 YNLEKKSVL--DKDRLRKEIIQRVNLVANEFHKVT--TNRMWETTKRAIKENNGITLQMA 239
L++ V + +R+R E+ +V + E VT ++ + + K+ + + Q+
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 240 RVSQ-------QGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK 292
+ Q + L + +Q++ +N+ +QLE E + + + + + K
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK 1371
Query: 293 KCQEQQQDTKEAEELRLLLSQ----LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQR 348
K ++ + AEE++ L + L QR + L+ + +L +L+ VDL
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH 1431
Query: 349 LQQELANEQKVRASLEAALVQ 369
+Q N +K + + L +
Sbjct: 1432 QRQSACNLEKKQKKFDQLLAE 1452
Score = 52.8 bits (125), Expect = 8e-07
Identities = 79/393 (20%), Positives = 172/393 (43%), Gaps = 35/393 (8%)
Query: 44 QIRDLEDRLARYQRKWDELAVQ-EKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLN 102
+ +L RL +++ +E+ E +E E+ + + E K+ + Q + E+ +
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAE-----KKKMQQNIQELEEQL 952
Query: 103 EQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQ---LTTENIILGGKLAALEEFRLQKE 159
E+ ++ + ++EK EA+L ++ E +DQ L E +L ++A EF
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA---EFTTNLT 1009
Query: 160 EVTDKFTLLEEQVRKQENEFRDYAYNL--EKKSVLDKDRLRKEIIQRVNLVANEFHKVTT 217
E +K L + K E D L E+K + ++ R+++ ++++ ++
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 218 NRMWETTKRAIKENNGITLQMARVSQQGMK---LLQENEQLKGRQNNLCKQLELLENTQK 274
++ E + K+ + +ARV ++ + L++ +L+ + + L + LE ++
Sbjct: 1070 -QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN 1128
Query: 275 VMARHKR--GHQKIIL------MLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQ 326
+ KR G + L L +Q+ +K +E+ +L LE+ + + Q
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 327 ALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEED 386
++ + Q +L +Q L++ ++ AN +K + +LE + + ++ +LQ D E
Sbjct: 1189 EMRQKHSQAVEELAEQ---LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 387 SDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKA 419
V Q LQ+L V + R + A
Sbjct: 1246 KRKKVEAQ------LQELQVKFNEGERVRTELA 1272
Score = 52.0 bits (123), Expect = 1e-06
Identities = 78/376 (20%), Positives = 153/376 (40%), Gaps = 57/376 (15%)
Query: 16 VKKKGGKKEPVVAVEPPLAK---EMKEFYHIQIRDLEDRLARYQRKWDELAVQE------ 66
++KK K + ++A E ++ E ++ + R+ E + R +E Q+
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498
Query: 67 -KMFRQEFEQLANNKKEIVAFL------KRTLNQQVDEITDLNEQLQNLQLAKEMEKDAF 119
K FR E E L ++K ++ + KR L QQV+E+ E+L++ A E K
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 120 EAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEF 179
E L ++ +F+ + + + E+ +K L QVR+ E E
Sbjct: 1559 EVNLQAMKAQFER--------------------DLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 180 RDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQM- 238
D E+K RK++ ++L E H + N+ AIK+ + QM
Sbjct: 1599 ED-----ERKQRSMAVAARKKL--EMDLKDLEAHIDSANK---NRDEAIKQLRKLQAQMK 1648
Query: 239 --------ARVSQQG-MKLLQENEQ-LKGRQNNLCKQLELLENTQKVMARHKRGHQKIIL 288
R S++ + +ENE+ LK + + + E L ++ + ++ ++
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708
Query: 289 MLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQR 348
+ + +E L ++QLE+ + Q + + + + + +LQ++Q DL
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768
Query: 349 LQQELANEQKVRASLE 364
+ + R LE
Sbjct: 1769 ERSHAQKNENARQQLE 1784
Score = 49.7 bits (117), Expect = 7e-06
Identities = 94/454 (20%), Positives = 183/454 (40%), Gaps = 58/454 (12%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELA 63
KK++ + K E + + +++ AVE LA+++++ ++ +LE + + ELA
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEE-LAEQLEQTKRVKA-NLEKAKQTLENERGELA 1230
Query: 64 VQEKMFRQEFEQLANNKKEIVAFLK----------RTLNQQVDEITDLNEQLQN---LQL 110
+ K+ Q + +K++ A L+ R + D++T L +L N L
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 111 AKEMEKDAFEAQLAQVRHEFQETKDQLTTEN---IILGGKLAALEE----FRLQKEEVTD 163
+ + + + + Q+T++ L EN + L KL +E+ FR Q EE +
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350
Query: 164 KFTLLEEQVRKQENEFRDYAYNLEKK-SVLDKDRLRKEIIQR--VNLVANEFHKVTTNRM 220
LE+Q+ + D +E L+ K +Q+ L KV
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK 1410
Query: 221 WETTK-RAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARH 279
E TK R +E + + + + Q L E +Q K Q LL + + A++
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSACNL--EKKQKKFDQ--------LLAEEKTISAKY 1460
Query: 280 KRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQ----- 334
+ +K + + EE ++LE+ + Q + + + L S +D
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 335 ---------LSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEE 385
L Q+E+ + L+ L+ EL + + LE L + + LQ RDE+
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ-GRDEQ 1579
Query: 386 DSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKA 419
+ K++++Q+ M + R Q++
Sbjct: 1580 SEEK-------KKQLVRQVREMEAELEDERKQRS 1606
Score = 42.7 bits (99), Expect = 8e-04
Identities = 40/189 (21%), Positives = 90/189 (47%), Gaps = 17/189 (8%)
Query: 238 MARVSQQGMKLLQENEQL-KGRQNNLCKQLEL--LENTQKVMARHKRGHQKIILMLTKKC 294
+ +VS+Q +++ + E+L K R+ L + L +E Q + K L L ++
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK-------LQLQEQL 889
Query: 295 QEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQ----LSLQLEQQQVDLQRLQ 350
Q + + EAEELR L+ +Q ++ D +A + ++ L + ++ Q ++Q L+
Sbjct: 890 QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 351 QELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSS 410
++L E+ R L+ V + L+ + + ED + + + K++L+ + ++
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE---KKLLEDRIAEFTT 1006
Query: 411 TVATRPQKA 419
+ +K+
Sbjct: 1007 NLTEEEEKS 1015
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 67.0 bits (162), Expect = 4e-11
Identities = 61/346 (17%), Positives = 169/346 (48%), Gaps = 28/346 (8%)
Query: 44 QIRDLEDRLARYQRK-WDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLN 102
+IR+ E+++ R + W++ +EKM RQE ++ K+E + + + ++ ++I +L
Sbjct: 390 KIREQEEKMRRQEEMMWEK---EEKMRRQE--EMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 103 EQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEE-FRLQKEEV 161
E++ + +E E+ E + + + + QE + ++ + K+ EE R Q+E++
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE----EKIREQEEKIREQEEKM 500
Query: 162 TDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTN--R 219
+ + EQ + +E E R + ++ +K R ++EI ++ + + K+ +
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQE--EKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 220 MWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARH 279
MW ++ + I Q +V +Q K+ ++ E+++ ++ + +Q E+ + ++ M
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 280 KRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQL 339
+ K C+++++ ++ E++R ++ ++ +++ + ++ Q + +
Sbjct: 619 EE----------KMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE---MMQ 665
Query: 340 EQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEE 385
EQ++ ++ ++ E+K++ E Q + +++ + EE
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Score = 51.2 bits (121), Expect = 2e-06
Identities = 71/448 (15%), Positives = 186/448 (41%), Gaps = 63/448 (14%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFE 74
E+K+K K + + L + K + +++L+ +L R + L + ++ + E +
Sbjct: 279 ELKEKNAKLQEKLQ----LVESEKSEIQLNVKELKRKLERAK-----LLLPQQQLQAEAD 329
Query: 75 QLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETK 134
L + + A L+ + + + LN+Q + +E + +E ++ + + +E +
Sbjct: 330 HLGKELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 388
Query: 135 DQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDK 194
+++ + E+ R Q+E + +K EE++R+QE + + E+K +
Sbjct: 389 EKIREQE----------EKMRRQEEMMWEK----EEKMRRQE----EMMWEKEEKMRRQE 430
Query: 195 DRL--RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN 252
+ + ++E I+ + +E K+ + I+E Q A++ +Q K+ ++
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 490
Query: 253 EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLS 312
E+++ ++ + +Q E + +K+ KR Q+ + +K +EQ++ ++ E++
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 313 QLEQRSLQLQVDNQALKSQ--------------------------------RDQLSLQLE 340
++ ++ ++ + + Q R+Q + E
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 341 QQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEED-SDVDVTFQPWHKE 399
Q++ ++ ++ E+K++ E Q + ++ EE + + Q ++
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 670
Query: 400 MLQQLLVMLSSTVATRPQKAACPHQESQ 427
M +Q M + Q+ QE +
Sbjct: 671 MWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 66.6 bits (161), Expect = 5e-11
Identities = 66/352 (18%), Positives = 173/352 (49%), Gaps = 28/352 (7%)
Query: 44 QIRDLEDRLARYQRK-WDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLN 102
+IR+ E+++ R + W++ +EKM RQE ++ K+E + L+ + ++ ++I +L
Sbjct: 329 KIREQEEKMRRQEEMMWEK---EEKMRRQE--EMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 103 EQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVT 162
E++ + +E E+ E + + + + QE + ++ + E+ R Q+E++
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE----------EKIREQEEKIR 433
Query: 163 D---KFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRK-EIIQRVNLVANEFHKVTTN 218
+ K EE++ +QE + +++ ++++R+ E I R +E K+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 219 --RMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVM 276
++W ++ + I Q ++ +Q K+ ++ E+++ ++ + +Q E+++ ++ M
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 277 ARH--KRGHQKIILMLTKKCQEQQQDTKEAEE-LRLLLSQLEQRSLQLQVDNQALKSQRD 333
K Q+ + +K +EQ++ +E +E +R ++ ++ +++ + ++ Q +
Sbjct: 554 GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613
Query: 334 QLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEE 385
++ Q E+ +++Q++ E+K+R E Q Q +M +E
Sbjct: 614 KMWEQEEKMCEQEEKMQEQ---EEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 58.2 bits (139), Expect = 2e-08
Identities = 61/357 (17%), Positives = 157/357 (43%), Gaps = 33/357 (9%)
Query: 60 DELAVQEKMFRQEFEQLANNKKEI---VAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEK 116
+EL + +++ + + + K EI V LKR L + + Q + L KE++
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 117 DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQE 176
+ + Q +E +Q E + + ++E+ + +E +K EE++R+QE
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEK--MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 177 NEFR---DYAYNLEKKSVLDKDRL----------------RKEIIQRVNLVANEFHKVTT 217
+ R + + E+K ++ + ++E I+ + +E K+
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE 394
Query: 218 NRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMA 277
+ I+E Q A++ +Q K+ ++ E+++ ++ + +Q E + +K+
Sbjct: 395 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 278 RHKRGHQKIILMLTKKCQEQQ------QDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQ 331
KR Q+ + +K +EQ+ + E E++R ++ ++ ++ + ++ Q
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 332 RDQLSLQ---LEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEE 385
+++ Q + +Q+ ++ ++++ ++++ E + + +Q +M R EE
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Score = 35.0 bits (79), Expect = 0.17
Identities = 37/180 (20%), Positives = 87/180 (48%), Gaps = 34/180 (18%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE----LAVQEKMFR 70
E ++K ++E + + +E +E +IR+ E+ + + K E + QEKM R
Sbjct: 513 EQEEKMWRQEEKIREQEEKIREQEE----KIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 71 QEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQL-QNLQLAKEMEKDAFEAQ--LAQVR 127
Q E+ ++E + K + +Q ++I + E++ + ++ +E E+ +E + + +
Sbjct: 569 Q--EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 626
Query: 128 HEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLE 187
+ QE + E+ R Q+E++ ++ E ++R+QE + +++ +LE
Sbjct: 627 EKMQEQE-----------------EKMRRQEEKMWEQ----EVRLRQQEEKMQEHQEHLE 665
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 66.6 bits (161), Expect = 5e-11
Identities = 63/318 (19%), Positives = 146/318 (45%), Gaps = 25/318 (7%)
Query: 71 QEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEF 130
QE LA ++K + + L ++++ L Q+Q L +EM + E + + +
Sbjct: 231 QEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRK 290
Query: 131 QETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKS 190
QE K E L E + E +K E+++R+QE E R+ ++K
Sbjct: 291 QEEKMWRQEER---------LREQEGKMREQEEKMWRQEKRLREQEKELRE-----QEKE 336
Query: 191 VLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQ 250
+ ++ LR++ E + +MWE ++ ++ + Q R+ +Q ++ +
Sbjct: 337 LREQKELREQ---------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 251 ENEQLKGRQNNLCKQLE-LLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL 309
+ ++++ ++ + +Q E L E +++ + K Q + KK QEQ++ T++ EE
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Query: 310 LLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQ-QVDLQRLQQELANEQKVRASLEAALV 368
++ +R +++ + + ++ Q +++ Q E + + + QQ+ EQK + + +
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 369 QATSFLQNILQMHRDEED 386
+ + + RD+E+
Sbjct: 508 EQEEKIWEQEEKIRDQEE 525
Score = 60.5 bits (145), Expect = 4e-09
Identities = 65/366 (17%), Positives = 180/366 (49%), Gaps = 34/366 (9%)
Query: 22 KKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKK 81
++E + E + K+ ++ + + R L ++ + + + +++ QEK R++ ++L +K
Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEER-LREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335
Query: 82 EIVAFLKRTLNQQVDEITDLNEQL--QNLQLAKEMEK-----DAFEAQLAQVRHEFQETK 134
E+ ++ L +Q +++ + E++ Q ++ ++ EK + Q Q+R + Q+ +
Sbjct: 336 ELRE--QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393
Query: 135 DQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL--EEQVRKQENEFRDYAYNL-EKKSV 191
DQ +L EE ++E++ ++ + E+++++QE + RD + E++ +
Sbjct: 394 DQ-EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Query: 192 LDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKR-----AIKENNGITLQMARVSQQGM 246
++++ +E + + + K N MWE ++ + E + ++ +Q
Sbjct: 453 REREKKMREEEETMREQEEKMQKQEEN-MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 247 KLLQENEQLK------GRQNNLCKQLELLENTQKVMARHKRGHQKIILM------LTKKC 294
K+ ++ E+++ G++ + +Q ++ E ++ + ++ + M + KK
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571
Query: 295 QEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRL--QQE 352
QEQ++ T + EE ++ +R +++ + + ++ Q +++ Q E+ Q +++ Q+E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 353 LANEQK 358
EQ+
Sbjct: 632 KMQEQE 637
Score = 43.1 bits (100), Expect = 6e-04
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 36/253 (14%)
Query: 135 DQLTTENIILGGKLAALEEFR--LQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVL 192
++LT E L +LE +R + EE+ K L+E++ E+E + N+
Sbjct: 200 EELTKERDAL-----SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNV------ 248
Query: 193 DKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN 252
KE+ +++ +V TN + E R +E + Q ++ +Q K+ ++
Sbjct: 249 ------KELKRKLERAKFLLPQVQTNTLQEEMWRQEEE---LREQEKKIRKQEEKMWRQE 299
Query: 253 EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLS 312
E+L+ ++ + +Q E + +K + + K+ +EQ+++ +E +ELR
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQE-----------KELREQEKELREQKELREQEE 348
Query: 313 QLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATS 372
Q++++ ++ + ++ Q +++ Q E+ ++++++ EQK+R E Q
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ---EQKMRDQEERMWEQDER 405
Query: 373 FLQNILQMHRDEE 385
+ +M E+
Sbjct: 406 LREKEERMREQEK 418
Score = 38.9 bits (89), Expect = 0.012
Identities = 54/302 (17%), Positives = 140/302 (46%), Gaps = 22/302 (7%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQE-KMFRQEF 73
E +KK ++E ++ + +E +E Q + ++ + Q + +++ QE KM+ QE
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 652
Query: 74 -----EQLANNKKEIVAFLKRTLNQQVDEITD-LNEQLQNLQLAKEMEKDAFEAQLAQVR 127
++L K+++ K +++ E + + EQ + + +E EK ++ + +
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712
Query: 128 HEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLE 187
+E + ++ E ++ + ++E + +E ++ EE++ +QE + + E
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPE 772
Query: 188 KKSVL---DKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQ 244
+K L +K + +++I ++ + ++ K+ R E R +E ++ Q
Sbjct: 773 QKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM---RGQEEKMRGQEE---------KMRGQ 820
Query: 245 GMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEA 304
K+ + E++ G++ + Q E + ++ M +G ++ + +K + Q++ +E
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
Query: 305 EE 306
EE
Sbjct: 881 EE 882
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 65.5 bits (158), Expect = 1e-10
Identities = 86/380 (22%), Positives = 167/380 (43%), Gaps = 61/380 (16%)
Query: 3 PKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDEL 62
P S E+ + + G++E + + ++ H Q++ + L Q+ +
Sbjct: 67 PAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDG 126
Query: 63 AVQEKMFRQEFEQLANNKK-----EIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKD 117
Q +QE Q ++++ +++ ++ QQV E L +Q + LQ + E+
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQ 186
Query: 118 AFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQEN 177
+ Q Q++ + QE ++ Q++E + LL++Q + Q+
Sbjct: 187 VLQQQ-EQLQQQVQE-------------------QQLLQQQQEQLQQQQLLQQQEQLQQQ 226
Query: 178 EFRDYAYNLEKKSVL----DKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNG 233
+F+ L+++ L + +L+++++Q+ ++A +
Sbjct: 227 QFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQ--------------------QQAQLQQQL 266
Query: 234 ITLQMARVSQQGMKLLQENEQLKGRQNN--LCKQLELLENTQ---KVMARHKRGHQKIIL 288
+ Q A++ QQ LLQ+ EQL+ +Q L +Q E L+ Q + + ++ L
Sbjct: 267 LEQQQAQLQQQ--LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELEL 324
Query: 289 MLTKKCQEQQ--QDTKEAEELRLLLSQLEQRSLQLQVDN--QALKSQRDQLSLQLEQQQV 344
M EQ+ Q +E E + L Q EQR LQL++ Q L+ Q +Q QLEQQ+V
Sbjct: 325 MPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEV 384
Query: 345 DLQRLQQEL-ANEQKVRASL 363
L+ EL A +Q+V+ L
Sbjct: 385 QLELTPVELGAQQQEVQLEL 404
Score = 58.2 bits (139), Expect = 2e-08
Identities = 89/365 (24%), Positives = 155/365 (42%), Gaps = 68/365 (18%)
Query: 104 QLQNLQLAKEMEKDAFEAQLAQVRH--EFQETKDQLTTENIILGGKLAALEEFRLQKEEV 161
QLQ L+ E ++ QL Q + E Q+ Q + + +LQ+E
Sbjct: 90 QLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLS-----------QLQQE-- 136
Query: 162 TDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMW 221
K + Q K E + L+ + V ++ RL++ Q+ L + + +
Sbjct: 137 --KHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQ---QQEQLQTQQAQEQQVLQQQ 191
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
E ++ ++E + Q ++ QQ +LLQ+ EQL+ Q +Q E L+ Q+++ ++
Sbjct: 192 EQLQQQVQEQQLLQQQQEQLQQQ--QLLQQQEQLQ--QQQFQQQQEQLQQQQQLLLLQQQ 247
Query: 282 GHQKIILMLTKKCQEQQQDTKEAE---ELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQ 338
G + L+ ++ Q QQQ ++ + + +LLL Q EQ LQ Q Q L+ Q++QL Q
Sbjct: 248 GQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQ--LQQQQQQQLLQQQQEQLQQQ 305
Query: 339 ----------------LEQQQVD------LQRLQQELANEQKVRASLEAALVQATSFLQN 376
LE VD L++ +QEL +Q++ E Q
Sbjct: 306 QLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQE----------QR 355
Query: 377 ILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGPPKESR 436
LQ+ EE ++ + ++ L+Q V L T P + QE Q P +
Sbjct: 356 QLQLKLQEELQQLEQQLEQ-QQQQLEQQEVQLELT----PVELGAQQQEVQLELTPVQ-- 408
Query: 437 PSIQL 441
P +QL
Sbjct: 409 PELQL 413
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/345 (19%), Positives = 145/345 (42%), Gaps = 54/345 (15%)
Query: 3 PKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDEL 62
P++ + +L+ +K + E L + ++ Q+++ + RL + Q +
Sbjct: 122 PQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQE-QQRLQQQQEQLQTQ 180
Query: 63 AVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQ 122
QE+ Q+ EQL +E ++ Q ++ EQLQ Q ++ E+ + Q
Sbjct: 181 QAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQ 240
Query: 123 LAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDY 182
L ++ + Q + L + L +L ++ +LQ++ LL++Q + Q+ + +
Sbjct: 241 LLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQ------LLLQQQEQLQQQQQQQL 294
Query: 183 AYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVS 242
+++L+++ +Q L E +V M + L +
Sbjct: 295 LQQ-------QQEQLQQQQLQPPPLEPEEEEEVELELM------------PVDLGSEQEL 335
Query: 243 QQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTK 302
+Q + L+ ++L+ +Q QL+L E Q+ L ++ ++QQQ
Sbjct: 336 EQQRQELERQQELERQQEQRQLQLKLQEELQQ---------------LEQQLEQQQQ--- 377
Query: 303 EAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQ 347
QLEQ+ +QL++ L +Q+ ++ L+L Q +LQ
Sbjct: 378 ----------QLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQ 412
Score = 39.3 bits (90), Expect = 0.009
Identities = 44/177 (24%), Positives = 80/177 (45%), Gaps = 15/177 (8%)
Query: 240 RVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQ 299
R Q+ ++L Q +Q + +Q Q E L+ Q + ++ Q L++ QE+ Q
Sbjct: 83 RPGQRELQLQQLEQQPEPQQQ---PQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQ 139
Query: 300 DTKEAE---ELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQ-LEQQQVDLQRLQ----- 350
E EL+L+ Q + + Q+Q + Q L+ Q++QL Q ++QQV Q+ Q
Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQ-EQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 351 --QELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLL 405
Q+L +Q+ + + L Q Q Q +++ + ++ QQLL
Sbjct: 199 QEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLL 255
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 65.5 bits (158), Expect = 1e-10
Identities = 77/324 (23%), Positives = 152/324 (46%), Gaps = 28/324 (8%)
Query: 74 EQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQET 133
E+ N K ++A ++ Q + TDL ++ N+++ + + L Q E + T
Sbjct: 652 EEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKAT 711
Query: 134 KDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKK-SVL 192
K +L +N I ++EE + + + +K LLEE+ KQ+ E + EK+ S+L
Sbjct: 712 KARLADKNKIY----ESIEEAKSEAMKEMEK-KLLEERTLKQKVE--NLLLEAEKRCSLL 764
Query: 193 DKDRLRK-----EIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGM- 246
D D + E++++ +++ + +T ET KR + +N+ + +Q +V+ M
Sbjct: 765 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQND-LKMQTQQVNTLKMS 823
Query: 247 --KLLQENEQLKGRQNNLCKQ-LELLENTQKVMARHKRGHQKIIL---MLTKKCQEQQQD 300
+L QEN L + NL KQ EL + Q + K ++ T + ++
Sbjct: 824 EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVREL 883
Query: 301 TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR 360
+E EE L +L+Q+ +LQ + +L +Q L++ + D ++L + +A EQ
Sbjct: 884 KEECEEKTKLGKELQQKKQELQDERDSLAAQ-----LEITLTKADSEQLARSIAEEQ--Y 936
Query: 361 ASLEAALVQATSFLQNILQMHRDE 384
+ LE + ++ ++ H+ E
Sbjct: 937 SDLEKEKIMKELEIKEMMARHKQE 960
Score = 42.0 bits (97), Expect = 0.001
Identities = 59/270 (21%), Positives = 114/270 (42%), Gaps = 32/270 (11%)
Query: 89 RTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKL 148
R L ++ +E T L ++LQ + + E+D+ AQL E TK ++ L +
Sbjct: 881 RELKEECEEKTKLGKELQQKKQELQDERDSLAAQL-----EITLTK----ADSEQLARSI 931
Query: 149 AALEEFRLQKEEVTDKFTLLEEQVR-KQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNL 207
A + L+KE++ + + E R KQE +D ++ + + + V
Sbjct: 932 AEEQYSDLEKEKIMKELEIKEMMARHKQELTEKD-------ATIASLEETNRTLTSDVAN 984
Query: 208 VANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLE 267
+ANE K N + + + + A + Q K L LK + N K E
Sbjct: 985 LANE--KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVN--KLAE 1040
Query: 268 LLENTQKV-------MARHKRGHQKIILMLT----KKCQEQQQDTKEAEELRLLLSQLEQ 316
++ + V + R ++ ++K+ + L K Q+ + KE E++ +++ Q
Sbjct: 1041 IMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQ 1100
Query: 317 RSLQLQVDNQALKSQRDQLSLQLEQQQVDL 346
++LQ+ + S +QL QL+ + L
Sbjct: 1101 IRIELQMTLDSKDSDIEQLRSQLQALHIGL 1130
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 65.5 bits (158), Expect = 1e-10
Identities = 79/350 (22%), Positives = 157/350 (44%), Gaps = 36/350 (10%)
Query: 45 IRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQ 104
+R+ + R Q + +E++ ++ EQ ++ F + L Q L E+
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE 1380
Query: 105 --LQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVT 162
L+ + ++ K+ + + + + ++ +D+ E EE +L ++E
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE-----------EEQQLSRQERD 1429
Query: 163 DKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANE---FHKVTTNR 219
KF E+QVR+QE E + LE++ L ++R RK + L E H+ +R
Sbjct: 1430 RKFREEEQQVRRQERERKF----LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 220 MW---ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVM 276
+ E R + + Q R + K L+E +QL +Q +Q + L+ Q+ +
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ----RQRKFLQEEQQ-L 1540
Query: 277 ARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLS 336
R +RG Q+ +K +E++Q +E EE +L ++R + +++ Q ++ Q +
Sbjct: 1541 RRQERGQQRR-QDRDRKFREEEQLRQEREEQQL---SRQERDRKFRLEEQKVRRQEQERK 1596
Query: 337 LQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEED 386
++QQ+ Q QQ+L E+ + + L+Q + Q+HR E D
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE----REEQQLHRQERD 1642
Score = 57.8 bits (138), Expect = 2e-08
Identities = 78/384 (20%), Positives = 174/384 (45%), Gaps = 37/384 (9%)
Query: 12 KELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQ 71
++L +++ ++E + E L +E + Q+R + Q + ++ +E+ R+
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 72 EFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQ 131
E +QL ++E ++ ++ + + Q L+ +E +D + + RHE +
Sbjct: 422 E-QQLRREQEE----------ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 132 ETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSV 191
K QL + Q+EE +++ LEE+ R+++ E R+ E++
Sbjct: 471 RRKQQLKRD----------------QEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 192 LDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQE 251
++ R+E +R+ ++ + E ++ +K L+ R +Q +K QE
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQE-ERREQLLKREEEKRLEQER-REQRLKREQE 572
Query: 252 N--EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL 309
+QL R+ +Q E +++ R KR + + ++ Q +++ E E +
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 310 LLS---QLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAA 366
LL Q E+R QL+ + Q + QR L + E+++++ QRL++E E++ + E
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQR--LKREEEEERLE-QRLKREHEEERREQELAEEE 689
Query: 367 LVQATSFLQNILQMHRDEEDSDVD 390
QA +++ + + + +S+ D
Sbjct: 690 QEQARERIKSRIPKWQWQLESEAD 713
Score = 55.8 bits (133), Expect = 9e-08
Identities = 74/349 (21%), Positives = 157/349 (44%), Gaps = 13/349 (3%)
Query: 44 QIRDLEDRLARYQ-RKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLN 102
Q+++ ED L Q R+ + +++ +R + E+ ++ + + K L +Q+ + L
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL-YAKPALQEQLRKEQQLL 906
Query: 103 EQLQNLQLAKEMEKDAFEAQLAQVRHE--FQETKDQLTTENIILGGKLAALEEFRLQKEE 160
++ + +E EK + Q Q R E Q+ ++QL E + ++R K+
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 161 VTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRM 220
+ LL E+ K+ + R+ Y E++ ++++L +E ++ E + +
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 221 WETTKRAIKENNGITLQMARVSQ--QGMKLLQENEQLKGRQNNLCKQLELLENTQKVMAR 278
+ ++ ++E R Q + +L QE EQL G + ++ EL +K
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 279 HKRGHQKIILMLTKKC-QEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSL 337
+ Q + K+ QE+++ +E EEL+ Q E++ L+ + + + + Q
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQ----QEEEQLLREEREKRRRQELERQYRE 1142
Query: 338 QLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEED 386
+ E QQ + Q L++E E++ R LE + Q Q+ R+E++
Sbjct: 1143 EEEVQQEEEQLLREE--PEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Score = 55.1 bits (131), Expect = 2e-07
Identities = 73/350 (20%), Positives = 161/350 (46%), Gaps = 47/350 (13%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFE 74
E +K+ K+E V+ E +E + ++++ E++L + +R+ EL + + Q+ +
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQ 298
Query: 75 QLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETK 134
+L ++ L+R +Q +E + E+ + Q +E +++ E QL + + E +E +
Sbjct: 299 RLRREQQ-----LRR---KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 135 DQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDK 194
+ E +L R Q+EE ++ E+Q+R+++ R+ E++ ++
Sbjct: 351 LRREQEEERREQQLR-----REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 195 DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQ 254
R++ ++R + E Q R Q+ + Q++EQ
Sbjct: 406 QLRREQQLRREQQLRRE-------------------------QQLRREQEEERHEQKHEQ 440
Query: 255 LKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQL 314
+ R+ L ++ E + K +R Q+ ++ Q+ ++D +E R L +
Sbjct: 441 ER-REQRLKREQEERRDWLKREEETERHEQE------RRKQQLKRDQEEERRERWLKLEE 493
Query: 315 EQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLE 364
E+R Q + Q L+ ++++ Q ++Q + +RLQQ L +EQ++R E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543
Score = 54.7 bits (130), Expect = 2e-07
Identities = 69/308 (22%), Positives = 138/308 (44%), Gaps = 34/308 (11%)
Query: 44 QIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNE 103
Q RD E R+Q++ +E++ R+E ++ A + K+ L ++ +E E
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKE-AKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 104 QLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTD 163
+ + +++ ++ E L + + + +++L + G+ EE RL+++E
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE---QGRKFLEEEQRLRRQERER 1390
Query: 164 KFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWET 223
KF E+Q+R QE E ++ D+DR +E Q+++ +
Sbjct: 1391 KFLKEEQQLRCQERE---------QQLRQDRDRKFREEEQQLSRQERD------------ 1429
Query: 224 TKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGH 283
R +E Q R ++ K L+E +QL+ ++ ++ E L ++ H++
Sbjct: 1430 --RKFREEE----QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 284 QKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQ 343
+ L ++ + Q++D K E+ L SQ +R L+ + Q + QR + LQ EQQ
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQ--ELRSQEPERKF-LEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 344 VDLQRLQQ 351
+R QQ
Sbjct: 1541 RRQERGQQ 1548
Score = 53.9 bits (128), Expect = 3e-07
Identities = 83/361 (22%), Positives = 166/361 (45%), Gaps = 43/361 (11%)
Query: 49 EDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQ-LQN 107
E +L R +R +++ FR+E EQL ++E ++ Q+ D L EQ ++
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREE-EQLRQEREE-----QQLSRQERDRKFRLEEQKVRR 1590
Query: 108 LQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTL 167
+ ++ +D + + + + + ++ +D+ E+ L L EE +L ++E KF
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL---LQEREEQQLHRQERDRKFLE 1647
Query: 168 LEEQVRKQENEF-----RDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWE 222
E Q+R+QE E RD + E++ + + + + +R E ++ R E
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL---RRQE 1704
Query: 223 TTKRAIKENNGITLQ-MARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
++ ++E + Q + R ++ +L QE EQ + R+ + ++LE Q R +R
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE--RYRKILEEEQ---LRPER 1759
Query: 282 GHQKIILM-LTKKCQEQQQDTKEAEELRLLLSQL-----EQRSLQLQVDNQALKSQR--- 332
Q++ +K +E++Q +E EE +L + E+ L+ + + Q L+ Q+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 333 ----DQLSLQLEQQQVDLQRLQQELANEQKVR---ASLEAALVQATSFLQNILQMHRDEE 385
++ LQLE+Q+ QRL+QE + + A+ E + + Q Q R E
Sbjct: 1820 KYRWEEEQLQLEEQE---QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 386 D 386
+
Sbjct: 1877 E 1877
Score = 53.9 bits (128), Expect = 3e-07
Identities = 78/337 (23%), Positives = 148/337 (43%), Gaps = 45/337 (13%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQL 105
R DR R + + QE+ F ++ +QL ++E L++ +++ E L ++
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQL--RRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 106 QNLQLAKEMEKDAFEAQLAQVRHEFQET-----KDQLTTENIILGGKLAALEEFRLQKEE 160
+ QL ++ F + Q+R + +E +D+ E L L EE +L+++E
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL---LQEGEEQQLRRQE 1688
Query: 161 VTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRM 220
KF E+Q+R+QE E+K + ++ +LR++ ++R + + T
Sbjct: 1689 RDRKFREEEQQLRRQER---------ERKFLQEEQQLRRQELERKFREEEQLRQETEQ-- 1737
Query: 221 WETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHK 280
E +R + + + R ++ +L ++ K R+ +QL Q++ ++
Sbjct: 1738 -EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE---EQLRQEREEQQLRSQES 1793
Query: 281 RGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQ------LEQRSLQLQVDNQALKSQRDQ 334
+K +E++Q +E EE +L Q E+ LQL+ Q L+ +RD+
Sbjct: 1794 ----------DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR 1843
Query: 335 LSLQLEQ--QQVDLQRLQQEL--ANEQKVRASLEAAL 367
EQ Q +R +QEL EQK R E L
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKL 1880
Score = 53.1 bits (126), Expect = 6e-07
Identities = 68/293 (23%), Positives = 136/293 (46%), Gaps = 35/293 (11%)
Query: 93 QQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE 152
+Q E+ + EQ + + ++ ++ + +L + R E+QE +++ E E
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE-----------E 191
Query: 153 EFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEF 212
+ + K T++F EEQ+R++E L +K +K + R+E RV E
Sbjct: 192 QLQSCKGHETEEFP-DEEQLRRRE------LLELRRKGREEKQQQRRERQDRV--FQEEE 242
Query: 213 HKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENT 272
K R ET R +E LQ +Q +L +E EQL+ + ++L
Sbjct: 243 EKEWRKR--ETVLRKEEEK----LQEEEPQRQ-RELQEEEEQLRKLER---QELRRERQE 292
Query: 273 QKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR 332
++ + R Q++ ++ +EQQ++ +E +E R Q E+R QL+ + + + Q+
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERR--EQQEERREQQLRREQEERREQQ 350
Query: 333 DQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEE 385
+ + E+++ L+R Q+E EQ++R + Q L+ Q+ R+++
Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ---LRREQQLRREQQ 400
Score = 50.8 bits (120), Expect = 3e-06
Identities = 81/410 (19%), Positives = 169/410 (41%), Gaps = 72/410 (17%)
Query: 13 ELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQ- 71
+ E K + G++ ++ PPL ++ + Q+R E+R R QR E +E+ RQ
Sbjct: 772 QAEEKSERGRQR--LSARPPLREQRER----QLR-AEERQQREQRFLPEEEEKEQRRRQR 824
Query: 72 -EFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKD------------- 117
E E+ +E +R QQ+ E D ++ Q + ++E +D
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 118 ---------AFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL 168
A + QL + + QE +++L E + ++R +++ ++ LL
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 169 EEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAI 228
E+ K+ + R+ Y +KK +++L E E KR
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGE---------------------EPEKRRR 983
Query: 229 KENNGITLQMARVSQQGMKLLQENEQLKGRQN--NLCKQLELLENTQKVMARHKRGHQKI 286
+E + + Q+ +LL+E + + RQ ++ + L+ ++ + R +R +++
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043
Query: 287 ILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDL 346
QE+++ +E EEL+ QL + + + + R + LQ E++Q+
Sbjct: 1044 --------QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 347 QRLQQELANEQKVRASLEAALVQATSFL----------QNILQMHRDEED 386
+ ++ E++ + E L Q L Q + + +R+EE+
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Score = 48.1 bits (113), Expect = 2e-05
Identities = 77/395 (19%), Positives = 164/395 (41%), Gaps = 68/395 (17%)
Query: 15 EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMF----- 69
E++++ ++E V E L +E E + L R R+ +EL +E+
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPE------KRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 70 ---RQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQ---------NLQLAKEMEKD 117
RQE E+ ++E+ ++ + D+ +DL Q + N K E +
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 118 AFEAQLAQVRHEFQETKDQLTTENI--ILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQ 175
F + E + +D+ + +++ +LG + E ++ + D+ EEQ+ ++
Sbjct: 1249 QFR------QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 176 ENEF--RDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNG 233
E + R + E+K +L ++R K Q + E ++ R + +R ++
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK- 1361
Query: 234 ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKK 293
+ R +QG K L+E ++L+ ++ ++ + L+ Q++ +
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQE----RERKFLKEEQQL-----------------R 1400
Query: 294 CQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL 353
CQE++Q ++ + + + + Q + +RD+ + EQQ +R ++ L
Sbjct: 1401 CQEREQQLRQDRDRKFR-----------EEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449
Query: 354 ANEQKVRASLEAALVQATSFLQ--NILQMHRDEED 386
EQ++R + LQ Q+HR E D
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/368 (20%), Positives = 160/368 (43%), Gaps = 49/368 (13%)
Query: 12 KELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQ 71
+E +K++ K+ E L +E +E ++ E+R + ++ E +++++ R+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 72 EFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQ 131
E E+L ++ ++ L ++ E E+ Q L ++E E E + Q+R E Q
Sbjct: 606 EVERLEQEERR-----EQRLKREEPE----EERRQQLLKSEEQE----ERRQQQLRREQQ 652
Query: 132 ETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSV 191
E ++Q RL++EE ++ LE++++++ E R E++
Sbjct: 653 ERREQ------------------RLKREEEEER---LEQRLKREHEEERREQELAEEEQE 691
Query: 192 LDKDRLRKEIIQ-----RVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGM 246
++R++ I + A + + R E +R ++ + + + Q
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 247 KLLQENEQLKGRQNNLCKQLELLENT----QKVMARHK-RGHQKIILMLTKKCQEQQQDT 301
+ +Q + ++ + Q + E + Q++ AR R ++ L ++ Q +Q+
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 302 KEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQ-----RLQQELANE 356
E EE Q +R +LQ + + QR + + QL++++ LQ R QE +
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 357 QKVRASLE 364
QK R LE
Sbjct: 872 QKWRWQLE 879
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 65.1 bits (157), Expect = 1e-10
Identities = 93/453 (20%), Positives = 196/453 (43%), Gaps = 62/453 (13%)
Query: 35 KEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLA---NNKKEIVAFLKRTL 91
K+MK+ + + L +A + K+DE + Q+ +L N + ++ LK L
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 92 NQQ--VDEITDLNEQL-------QNLQLAKEMEKDAFEAQLAQVRHEF---QETKDQLTT 139
Q+ ++++ L ++L N+ L +E E + + + +++ ++ + T QL +
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 140 ENIILGGKLAALEEFRLQK-----EEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVL-- 192
E + G + A+ LQK E+T K L E + K+E ++ ++SV
Sbjct: 275 E-LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
Query: 193 -------DKDRLRKEIIQRVNLVANEFHK--VTTNRMWETTKRAIKENNGITLQMARVSQ 243
KD +++ R++ H+ V + E T++ +E + + + +
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 244 QGMKLLQENE-------QLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
+ +L Q+ E QL+ N L +LLE +++ H R ++ L K +
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQL--HSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQV------------ 344
+QQ +L+L LS+LE++ + ++ L+ Q D+ Q ++QQ
Sbjct: 452 EQQ----VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 345 --DLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQ 402
DL+++ +++ ++ + +LEA L ++ +NI + ++ ED + +L
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSK---ENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 403 QLLVMLSSTVATRPQKAACPHQESQSHGPPKES 435
QL + Q +S+SH +E+
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Score = 53.9 bits (128), Expect = 3e-07
Identities = 83/430 (19%), Positives = 181/430 (42%), Gaps = 51/430 (11%)
Query: 7 VSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQE 66
+ K ++L K + G+ E V + +E Q+ L ++L + QE
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQ---LQEKNHTLQEQVTQLTEKLKNQSESHKQ--AQE 596
Query: 67 KMFRQEFEQLANNK--KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLA 124
+ Q EQ A+ + ++ V L+ ++N+ ++ + E++ L + + + + + A
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 125 QVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAY 184
+ + ++ L T L K L + Q ++VT K +E + E+ ++Y
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY-- 714
Query: 185 NLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQ 244
K+ L ++ +E+ ++ + + +V +A KE LQ R
Sbjct: 715 ---KEKYLSLEQKTEELEGQIKKLEADSLEV----------KASKEQALQDLQQQR---- 757
Query: 245 GMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE----QQQD 300
Q N L+ R L KQLE+ +K + R L L KK + +Q+
Sbjct: 758 -----QLNTDLELRATELSKQLEM----EKEIVSSTR------LDLQKKSEALESIKQKL 802
Query: 301 TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR 360
TK+ EE ++L E S + ++ ++ L ++ +L++ +++ + L EL+ +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 361 ASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQ-KA 419
+ + +L + S + +++ + + KE+ QL V + +T+ + + K
Sbjct: 863 SKVSDSLKNSKSEFEK-----ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 420 ACPHQESQSH 429
+ ++ SH
Sbjct: 918 SLEKEKEASH 927
Score = 52.0 bits (123), Expect = 1e-06
Identities = 84/423 (19%), Positives = 190/423 (44%), Gaps = 42/423 (9%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYH---IQIRDLEDRLARYQRKWD 60
+K+ + +L+V+ + KE ++ L KE KE H +++ ++++L + Q
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQK-ELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 61 ELAVQEKMFR---QEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQN--LQLAKEME 115
+ +E+ + E +Q + KK+ + L+ L V + T+L +LQ Q A+E+
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 116 KDAFEAQLAQVRHE-FQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRK 174
+ + + Q +E QET QL ++ G+ + L R + V +K +L +E +
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSD---FYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 175 QENEFRDYAYNLEK----KSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKE 230
N+ + +++ K+ L++D +KE Q++ + + + K + E
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKE--QQLQERCKALQDIQKEKSLK-EKELVNE 1122
Query: 231 NNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILML 290
+ + +Q ++ + NE+LK + K++ L++ ++++ + K Q
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ------ 1176
Query: 291 TKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ 350
+A+ L+ + Q E+R+ Q+ D +K + ++L + +++ L
Sbjct: 1177 -----------GKADSLKAAVEQ-EKRNQQILKDQ--VKKEEEELKKEFIEKEAKLHSEI 1222
Query: 351 QELANEQKVRASLEAAL-VQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLS 409
+E K EA L +Q T+ +N+ + ++ + S V+ + L+ + +L
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 410 STV 412
+TV
Sbjct: 1283 ATV 1285
Score = 33.5 bits (75), Expect = 0.48
Identities = 49/219 (22%), Positives = 86/219 (39%), Gaps = 29/219 (13%)
Query: 230 ENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILM 289
+ + +TL V L +E K L K+LE + Q+ A+ ++
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEE----KWYSEELKKELEKYQGLQQQEAKP----DGLVTD 132
Query: 290 LTKKCQEQQQDTKEAEELRLLLSQL----EQRSLQLQVDNQALKSQRDQLSLQLEQQQVD 345
+ + Q +Q +EA+ + Q+ EQ++ QL + +KS+ D+ E +
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 346 LQRLQQELANEQKV----------------RASLEAALVQATSFLQNI-LQMHRDEEDSD 388
+ RL +EL E V A L+ LVQ + + N+ L+ R+ E
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 389 VDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQ 427
+ + + L S +A PQ+ A QE Q
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ 291
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 63.9 bits (154), Expect = 3e-10
Identities = 98/385 (25%), Positives = 165/385 (42%), Gaps = 66/385 (17%)
Query: 44 QIRDLEDRLARYQRKWD-ELAVQEKMFRQEF---EQLANNKKEIVAFLKRTLNQQVDEIT 99
+IR+LE ++ Q D E A + K +Q+ E+L K E+ L T QQ E+
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ--ELR 1169
Query: 100 DLNEQ-LQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLT-------------------- 138
EQ + L+ A + E + EAQ+ ++R + + ++LT
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 139 -TENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRL 197
EN L G+L L + K+EV K LE QV++ +++ D +R
Sbjct: 1230 EKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSK------------CSDGERA 1274
Query: 198 RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN----- 252
R E+ +V+ + NE V T + E +AIK + ++ Q +LLQE
Sbjct: 1275 RAELNDKVHKLQNEVESV-TGMLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKL 1332
Query: 253 ------EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
QL+ +N+L QL+ ++ + RH I L +KK + T EA E
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 307 LRLLLSQLEQRSLQLQVDNQA-----LKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRA 361
Q E +L Q + +A L+ +++L +L+ VDL +Q ++N +K +
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 362 SLEAALVQATSFLQNILQMHRDEED 386
+ L + +NI + DE D
Sbjct: 1452 KFDQLLAEE----KNISSKYADERD 1472
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/319 (24%), Positives = 134/319 (42%), Gaps = 45/319 (14%)
Query: 67 KMFRQEFEQLANNK---KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQL 123
K F + +QL K + A+LK Q T + LQ + +EM+ E Q
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 124 AQVRH--------EFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFT--------- 166
+ R E ++ QLT E +L +L A E + EE+ +
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923
Query: 167 LLEEQVRKQENEFRDYAYNLEKKSVLDK-----DRLRKEIIQRVNLVANEFHKVTTNRMW 221
L E + R +E E R E+K + + ++L +E R L + KVT
Sbjct: 924 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL---QLEKVTA---- 976
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
+ IK+ L M Q KL +E + L+ R ++L L E K + + K
Sbjct: 977 ---EAKIKKLEDEILVM---DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 282 GHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQ 341
H+ +I L + +++++ +E E+L+ +LE + L++Q +L +QL +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLK---RKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 342 QQVDLQ----RLQQELANE 356
++ +LQ RL E+A +
Sbjct: 1088 KEEELQAALARLDDEIAQK 1106
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/411 (21%), Positives = 182/411 (44%), Gaps = 66/411 (16%)
Query: 4 KKSVSKAGKEL--EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
K+++ K +L E++ G K+ V + K+ Q+++L+ + + +R E
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEV--------EHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 62 LAVQEKMFRQEFEQL------ANNKKEIVAFLKRTLNQQVDEITDL--NEQLQNLQLAKE 113
L + + E E + A K +A +L+ Q+ + +L E Q L ++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 114 M-----EKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL 168
+ E+++ + QL + Q + ++T NI L L++F E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 169 EEQVRK--QENEFRDYAYNLEKKSVLDKDRLRKEIIQRV-------NLVAN------EFH 213
++++ Q+ E + AY+ +K+ K+RL++E+ V LV+N +F
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKT---KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 214 KVTTNRMWETTKRA---------IKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCK 264
++ ++K A +E L +AR ++ ++ +E E R N + K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE----RTNKMLK 1510
Query: 265 -QLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
++E L +++ + ++ +K L + +E + +E E+ L E L+L+V
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQATEDAKLRLEV 1567
Query: 324 DNQALKSQ-------RDQLSLQLEQQ-QVDLQRLQQELANEQKVRASLEAA 366
+ QALK Q RD+ + + +Q Q L + EL +E+K RA AA
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/424 (20%), Positives = 181/424 (42%), Gaps = 58/424 (13%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT----LNQQVDEITDL 101
R L L + QRK+D+L +EK ++ ++ E A K T L + ++E +
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 102 NEQLQ--NLQLAKEMEK-DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQK 158
E+L+ N L EME + + + + HE +++K L T+ +EE + Q
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----------MEEMKTQL 1548
Query: 159 EEVTDKFTLLEEQVRKQENEFR----DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHK 214
EE+ D+ E+ + E + + +L+ + ++++ R+ +QR + H+
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--LQR------QLHE 1600
Query: 215 VTTNRMWETTKRAI-----KENNG----ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQ 265
T E +RA+ K+ G + LQ + + +++ +L+ + + ++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 266 LELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL------------LLSQ 313
LE ++ + + ++K L + Q+D AE R L S
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL--ANEQKVRASLEAALVQAT 371
L R+ LQ + + L+++ QL +LE++Q +++ + + A +Q + S E A ++T
Sbjct: 1721 LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 372 SFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGP 431
+ + + ++ ++ EM + ST+A K A ++ +
Sbjct: 1780 AQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 432 PKES 435
K++
Sbjct: 1836 EKQA 1839
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/313 (24%), Positives = 127/313 (40%), Gaps = 58/313 (18%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
+L Q K F++E E ++ EI A K + DL + ++L A+ K
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---- 1704
Query: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
Q E +E ++L + L G+ A +E R LE ++ + E E
Sbjct: 1705 ----QADLEKEELAEELASS---LSGRNALQDEKRR-----------LEARIAQLEEELE 1746
Query: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
+ N+E S DR+RK Q+ ++NE T + ++N Q+ R
Sbjct: 1747 EEQGNMEAMS----DRVRKAT-QQAEQLSNEL---------ATERSTAQKNESARQQLER 1792
Query: 241 VSQQGMKLLQENE-QLKGRQNNLCKQLEL----LENTQKVMARHKRGHQKIILMLTKKCQ 295
+++ L E E +K + + LE LE + AR K+ K + KK +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR--DQLSLQLEQQQVDLQRLQQEL 353
E +LL ++R + Q QA K QL QLE+ + + QR+
Sbjct: 1853 E------------ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--- 1897
Query: 354 ANEQKVRASLEAA 366
AN +K++ L+ A
Sbjct: 1898 ANRRKLQRELDEA 1910
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/133 (22%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
++ + ++ K E ++L+ + + L ++ LL+ + +++ + L K QE
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ-QELAN 355
++ E E L + E R QLQ + + + Q L QLE+++ Q+LQ +++
Sbjct: 920 LEEILHEMEAR---LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 356 EQKVRASLEAALV 368
E K++ + LV
Sbjct: 977 EAKIKKLEDEILV 989
Score = 35.8 bits (81), Expect = 0.097
Identities = 57/305 (18%), Positives = 128/305 (41%), Gaps = 43/305 (14%)
Query: 6 SVSKAGKELEVKKKGGKKEPVVAVEPPLA-KEMKEFYHIQIRDLEDRLARYQRKWDELAV 64
+ +A K+ +++K+ +E ++ A ++ K +I LE+ L Q + ++
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 65 QEKMFRQEFEQLANN--KKEIVAFLKRTLNQQVD-EITDLNEQLQNLQLAKEMEKDAFEA 121
+ + Q+ EQL+N + A + QQ++ + +L +L ++ A K F++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA---VKSKFKS 1814
Query: 122 QLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRD 181
+A + + + ++Q+ E K AA + + QK++ + L E RK ++++
Sbjct: 1815 TIAALEAKIAQLEEQVEQE---AREKQAATKSLK-QKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 182 YAYNLEKKSVLDKDRLR-KEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
A +K R K++ +++ E ++ NR R
Sbjct: 1871 QA---------EKGNARVKQLKRQLEEAEEESQRINANR--------------------R 1901
Query: 241 VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD 300
Q+ + E+ + GR+ N K N + + G +++I E++ D
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVI--ENADGSEEETD 1959
Query: 301 TKEAE 305
T++A+
Sbjct: 1960 TRDAD 1964
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 63.9 bits (154), Expect = 3e-10
Identities = 98/385 (25%), Positives = 165/385 (42%), Gaps = 66/385 (17%)
Query: 44 QIRDLEDRLARYQRKWD-ELAVQEKMFRQEF---EQLANNKKEIVAFLKRTLNQQVDEIT 99
+IR+LE ++ Q D E A + K +Q+ E+L K E+ L T QQ E+
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ--ELR 1176
Query: 100 DLNEQ-LQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLT-------------------- 138
EQ + L+ A + E + EAQ+ ++R + + ++LT
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 139 -TENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRL 197
EN L G+L L + K+EV K LE QV++ +++ D +R
Sbjct: 1237 EKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSK------------CSDGERA 1281
Query: 198 RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN----- 252
R E+ +V+ + NE V T + E +AIK + ++ Q +LLQE
Sbjct: 1282 RAELNDKVHKLQNEVESV-TGMLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKL 1339
Query: 253 ------EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
QL+ +N+L QL+ ++ + RH I L +KK + T EA E
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 307 LRLLLSQLEQRSLQLQVDNQA-----LKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRA 361
Q E +L Q + +A L+ +++L +L+ VDL +Q ++N +K +
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 362 SLEAALVQATSFLQNILQMHRDEED 386
+ L + +NI + DE D
Sbjct: 1459 KFDQLLAEE----KNISSKYADERD 1479
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/319 (24%), Positives = 134/319 (42%), Gaps = 45/319 (14%)
Query: 67 KMFRQEFEQLANNK---KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQL 123
K F + +QL K + A+LK Q T + LQ + +EM+ E Q
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 124 AQVRH--------EFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFT--------- 166
+ R E ++ QLT E +L +L A E + EE+ +
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930
Query: 167 LLEEQVRKQENEFRDYAYNLEKKSVLDK-----DRLRKEIIQRVNLVANEFHKVTTNRMW 221
L E + R +E E R E+K + + ++L +E R L + KVT
Sbjct: 931 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL---QLEKVTA---- 983
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
+ IK+ L M Q KL +E + L+ R ++L L E K + + K
Sbjct: 984 ---EAKIKKLEDEILVM---DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 282 GHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQ 341
H+ +I L + +++++ +E E+L+ +LE + L++Q +L +QL +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLK---RKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 342 QQVDLQ----RLQQELANE 356
++ +LQ RL E+A +
Sbjct: 1095 KEEELQAALARLDDEIAQK 1113
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/411 (21%), Positives = 182/411 (44%), Gaps = 66/411 (16%)
Query: 4 KKSVSKAGKEL--EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
K+++ K +L E++ G K+ V + K+ Q+++L+ + + +R E
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEV--------EHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 62 LAVQEKMFRQEFEQL------ANNKKEIVAFLKRTLNQQVDEITDL--NEQLQNLQLAKE 113
L + + E E + A K +A +L+ Q+ + +L E Q L ++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 114 M-----EKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL 168
+ E+++ + QL + Q + ++T NI L L++F E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 169 EEQVRK--QENEFRDYAYNLEKKSVLDKDRLRKEIIQRV-------NLVAN------EFH 213
++++ Q+ E + AY+ +K+ K+RL++E+ V LV+N +F
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKT---KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 214 KVTTNRMWETTKRA---------IKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCK 264
++ ++K A +E L +AR ++ ++ +E E R N + K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE----RTNKMLK 1517
Query: 265 -QLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
++E L +++ + ++ +K L + +E + +E E+ L E L+L+V
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQATEDAKLRLEV 1574
Query: 324 DNQALKSQ-------RDQLSLQLEQQ-QVDLQRLQQELANEQKVRASLEAA 366
+ QALK Q RD+ + + +Q Q L + EL +E+K RA AA
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/424 (20%), Positives = 181/424 (42%), Gaps = 58/424 (13%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT----LNQQVDEITDL 101
R L L + QRK+D+L +EK ++ ++ E A K T L + ++E +
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 102 NEQLQ--NLQLAKEMEK-DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQK 158
E+L+ N L EME + + + + HE +++K L T+ +EE + Q
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----------MEEMKTQL 1555
Query: 159 EEVTDKFTLLEEQVRKQENEFR----DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHK 214
EE+ D+ E+ + E + + +L+ + ++++ R+ +QR + H+
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--LQR------QLHE 1607
Query: 215 VTTNRMWETTKRAI-----KENNG----ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQ 265
T E +RA+ K+ G + LQ + + +++ +L+ + + ++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 266 LELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL------------LLSQ 313
LE ++ + + ++K L + Q+D AE R L S
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL--ANEQKVRASLEAALVQAT 371
L R+ LQ + + L+++ QL +LE++Q +++ + + A +Q + S E A ++T
Sbjct: 1728 LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 372 SFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGP 431
+ + + ++ ++ EM + ST+A K A ++ +
Sbjct: 1787 AQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 432 PKES 435
K++
Sbjct: 1843 EKQA 1846
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/313 (24%), Positives = 127/313 (40%), Gaps = 58/313 (18%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
+L Q K F++E E ++ EI A K + DL + ++L A+ K
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---- 1711
Query: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
Q E +E ++L + L G+ A +E R LE ++ + E E
Sbjct: 1712 ----QADLEKEELAEELASS---LSGRNALQDEKRR-----------LEARIAQLEEELE 1753
Query: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
+ N+E S DR+RK Q+ ++NE T + ++N Q+ R
Sbjct: 1754 EEQGNMEAMS----DRVRKAT-QQAEQLSNEL---------ATERSTAQKNESARQQLER 1799
Query: 241 VSQQGMKLLQENE-QLKGRQNNLCKQLEL----LENTQKVMARHKRGHQKIILMLTKKCQ 295
+++ L E E +K + + LE LE + AR K+ K + KK +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR--DQLSLQLEQQQVDLQRLQQEL 353
E +LL ++R + Q QA K QL QLE+ + + QR+
Sbjct: 1860 E------------ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--- 1904
Query: 354 ANEQKVRASLEAA 366
AN +K++ L+ A
Sbjct: 1905 ANRRKLQRELDEA 1917
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/133 (22%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
++ + ++ K E ++L+ + + L ++ LL+ + +++ + L K QE
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ-QELAN 355
++ E E L + E R QLQ + + + Q L QLE+++ Q+LQ +++
Sbjct: 927 LEEILHEMEAR---LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 356 EQKVRASLEAALV 368
E K++ + LV
Sbjct: 984 EAKIKKLEDEILV 996
Score = 35.8 bits (81), Expect = 0.097
Identities = 57/305 (18%), Positives = 128/305 (41%), Gaps = 43/305 (14%)
Query: 6 SVSKAGKELEVKKKGGKKEPVVAVEPPLA-KEMKEFYHIQIRDLEDRLARYQRKWDELAV 64
+ +A K+ +++K+ +E ++ A ++ K +I LE+ L Q + ++
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 65 QEKMFRQEFEQLANN--KKEIVAFLKRTLNQQVD-EITDLNEQLQNLQLAKEMEKDAFEA 121
+ + Q+ EQL+N + A + QQ++ + +L +L ++ A K F++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA---VKSKFKS 1821
Query: 122 QLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRD 181
+A + + + ++Q+ E K AA + + QK++ + L E RK ++++
Sbjct: 1822 TIAALEAKIAQLEEQVEQE---AREKQAATKSLK-QKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 182 YAYNLEKKSVLDKDRLR-KEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
A +K R K++ +++ E ++ NR R
Sbjct: 1878 QA---------EKGNARVKQLKRQLEEAEEESQRINANR--------------------R 1908
Query: 241 VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD 300
Q+ + E+ + GR+ N K N + + G +++I E++ D
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVI--ENADGSEEETD 1966
Query: 301 TKEAE 305
T++A+
Sbjct: 1967 TRDAD 1971
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 63.9 bits (154), Expect = 3e-10
Identities = 98/385 (25%), Positives = 165/385 (42%), Gaps = 66/385 (17%)
Query: 44 QIRDLEDRLARYQRKWD-ELAVQEKMFRQEF---EQLANNKKEIVAFLKRTLNQQVDEIT 99
+IR+LE ++ Q D E A + K +Q+ E+L K E+ L T QQ E+
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ--ELR 1176
Query: 100 DLNEQ-LQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLT-------------------- 138
EQ + L+ A + E + EAQ+ ++R + + ++LT
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 139 -TENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRL 197
EN L G+L L + K+EV K LE QV++ +++ D +R
Sbjct: 1237 EKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSK------------CSDGERA 1281
Query: 198 RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN----- 252
R E+ +V+ + NE V T + E +AIK + ++ Q +LLQE
Sbjct: 1282 RAELNDKVHKLQNEVESV-TGMLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKL 1339
Query: 253 ------EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
QL+ +N+L QL+ ++ + RH I L +KK + T EA E
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 307 LRLLLSQLEQRSLQLQVDNQA-----LKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRA 361
Q E +L Q + +A L+ +++L +L+ VDL +Q ++N +K +
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 362 SLEAALVQATSFLQNILQMHRDEED 386
+ L + +NI + DE D
Sbjct: 1459 KFDQLLAEE----KNISSKYADERD 1479
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/319 (24%), Positives = 134/319 (42%), Gaps = 45/319 (14%)
Query: 67 KMFRQEFEQLANNK---KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQL 123
K F + +QL K + A+LK Q T + LQ + +EM+ E Q
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 124 AQVRH--------EFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFT--------- 166
+ R E ++ QLT E +L +L A E + EE+ +
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930
Query: 167 LLEEQVRKQENEFRDYAYNLEKKSVLDK-----DRLRKEIIQRVNLVANEFHKVTTNRMW 221
L E + R +E E R E+K + + ++L +E R L + KVT
Sbjct: 931 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL---QLEKVTA---- 983
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
+ IK+ L M Q KL +E + L+ R ++L L E K + + K
Sbjct: 984 ---EAKIKKLEDEILVM---DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 282 GHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQ 341
H+ +I L + +++++ +E E+L+ +LE + L++Q +L +QL +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLK---RKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 342 QQVDLQ----RLQQELANE 356
++ +LQ RL E+A +
Sbjct: 1095 KEEELQAALARLDDEIAQK 1113
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/411 (21%), Positives = 182/411 (44%), Gaps = 66/411 (16%)
Query: 4 KKSVSKAGKEL--EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
K+++ K +L E++ G K+ V + K+ Q+++L+ + + +R E
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEV--------EHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 62 LAVQEKMFRQEFEQL------ANNKKEIVAFLKRTLNQQVDEITDL--NEQLQNLQLAKE 113
L + + E E + A K +A +L+ Q+ + +L E Q L ++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 114 M-----EKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL 168
+ E+++ + QL + Q + ++T NI L L++F E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 169 EEQVRK--QENEFRDYAYNLEKKSVLDKDRLRKEIIQRV-------NLVAN------EFH 213
++++ Q+ E + AY+ +K+ K+RL++E+ V LV+N +F
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKT---KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 214 KVTTNRMWETTKRA---------IKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCK 264
++ ++K A +E L +AR ++ ++ +E E R N + K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE----RTNKMLK 1517
Query: 265 -QLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
++E L +++ + ++ +K L + +E + +E E+ L E L+L+V
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQATEDAKLRLEV 1574
Query: 324 DNQALKSQ-------RDQLSLQLEQQ-QVDLQRLQQELANEQKVRASLEAA 366
+ QALK Q RD+ + + +Q Q L + EL +E+K RA AA
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/424 (20%), Positives = 181/424 (42%), Gaps = 58/424 (13%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT----LNQQVDEITDL 101
R L L + QRK+D+L +EK ++ ++ E A K T L + ++E +
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 102 NEQLQ--NLQLAKEMEK-DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQK 158
E+L+ N L EME + + + + HE +++K L T+ +EE + Q
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----------MEEMKTQL 1555
Query: 159 EEVTDKFTLLEEQVRKQENEFR----DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHK 214
EE+ D+ E+ + E + + +L+ + ++++ R+ +QR + H+
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--LQR------QLHE 1607
Query: 215 VTTNRMWETTKRAI-----KENNG----ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQ 265
T E +RA+ K+ G + LQ + + +++ +L+ + + ++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 266 LELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL------------LLSQ 313
LE ++ + + ++K L + Q+D AE R L S
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL--ANEQKVRASLEAALVQAT 371
L R+ LQ + + L+++ QL +LE++Q +++ + + A +Q + S E A ++T
Sbjct: 1728 LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 372 SFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGP 431
+ + + ++ ++ EM + ST+A K A ++ +
Sbjct: 1787 AQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 432 PKES 435
K++
Sbjct: 1843 EKQA 1846
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/313 (24%), Positives = 127/313 (40%), Gaps = 58/313 (18%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
+L Q K F++E E ++ EI A K + DL + ++L A+ K
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---- 1711
Query: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
Q E +E ++L + L G+ A +E R LE ++ + E E
Sbjct: 1712 ----QADLEKEELAEELASS---LSGRNALQDEKRR-----------LEARIAQLEEELE 1753
Query: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
+ N+E S DR+RK Q+ ++NE T + ++N Q+ R
Sbjct: 1754 EEQGNMEAMS----DRVRKAT-QQAEQLSNEL---------ATERSTAQKNESARQQLER 1799
Query: 241 VSQQGMKLLQENE-QLKGRQNNLCKQLEL----LENTQKVMARHKRGHQKIILMLTKKCQ 295
+++ L E E +K + + LE LE + AR K+ K + KK +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR--DQLSLQLEQQQVDLQRLQQEL 353
E +LL ++R + Q QA K QL QLE+ + + QR+
Sbjct: 1860 E------------ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--- 1904
Query: 354 ANEQKVRASLEAA 366
AN +K++ L+ A
Sbjct: 1905 ANRRKLQRELDEA 1917
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/133 (22%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
++ + ++ K E ++L+ + + L ++ LL+ + +++ + L K QE
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ-QELAN 355
++ E E L + E R QLQ + + + Q L QLE+++ Q+LQ +++
Sbjct: 927 LEEILHEMEAR---LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 356 EQKVRASLEAALV 368
E K++ + LV
Sbjct: 984 EAKIKKLEDEILV 996
Score = 34.3 bits (77), Expect = 0.28
Identities = 57/274 (20%), Positives = 110/274 (40%), Gaps = 53/274 (19%)
Query: 6 SVSKAGKELEVKKKGGKKEPVVAVEPPLA-KEMKEFYHIQIRDLEDRLARYQRKWDELAV 64
+ +A K+ +++K+ +E ++ A ++ K +I LE+ L Q + ++
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 65 QEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLA 124
+ + Q+ EQL+N +A + T + L Q KE+ E + A
Sbjct: 1765 RVRKATQQAEQLSNE----LATERSTAQKNESARQQLERQ------NKELRSKLHEMEGA 1814
Query: 125 QVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAY 184
V+ +F+ T +AALE K LEEQV ++ E
Sbjct: 1815 -VKSKFKST--------------IAALEA----------KIAQLEEQVEQEARE-----K 1844
Query: 185 NLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQ 244
KS+ KD+ KEI+ +V +M E K ++ N Q+ R ++
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVE---------DERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 245 GMKLLQENEQLKGRQNNLCKQLELLENTQKVMAR 278
+E++++ + L ++L+ + + M R
Sbjct: 1896 AE---EESQRINANRRKLQRELDEATESNEAMGR 1926
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 63.9 bits (154), Expect = 3e-10
Identities = 98/385 (25%), Positives = 165/385 (42%), Gaps = 66/385 (17%)
Query: 44 QIRDLEDRLARYQRKWD-ELAVQEKMFRQEF---EQLANNKKEIVAFLKRTLNQQVDEIT 99
+IR+LE ++ Q D E A + K +Q+ E+L K E+ L T QQ E+
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ--ELR 1169
Query: 100 DLNEQ-LQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLT-------------------- 138
EQ + L+ A + E + EAQ+ ++R + + ++LT
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 139 -TENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRL 197
EN L G+L L + K+EV K LE QV++ +++ D +R
Sbjct: 1230 EKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSK------------CSDGERA 1274
Query: 198 RKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQEN----- 252
R E+ +V+ + NE V T + E +AIK + ++ Q +LLQE
Sbjct: 1275 RAELNDKVHKLQNEVESV-TGMLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKL 1332
Query: 253 ------EQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEE 306
QL+ +N+L QL+ ++ + RH I L +KK + T EA E
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 307 LRLLLSQLEQRSLQLQVDNQA-----LKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRA 361
Q E +L Q + +A L+ +++L +L+ VDL +Q ++N +K +
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 362 SLEAALVQATSFLQNILQMHRDEED 386
+ L + +NI + DE D
Sbjct: 1452 KFDQLLAEE----KNISSKYADERD 1472
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/319 (24%), Positives = 134/319 (42%), Gaps = 45/319 (14%)
Query: 67 KMFRQEFEQLANNK---KEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQL 123
K F + +QL K + A+LK Q T + LQ + +EM+ E Q
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 124 AQVRH--------EFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFT--------- 166
+ R E ++ QLT E +L +L A E + EE+ +
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923
Query: 167 LLEEQVRKQENEFRDYAYNLEKKSVLDK-----DRLRKEIIQRVNLVANEFHKVTTNRMW 221
L E + R +E E R E+K + + ++L +E R L + KVT
Sbjct: 924 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL---QLEKVTA---- 976
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR 281
+ IK+ L M Q KL +E + L+ R ++L L E K + + K
Sbjct: 977 ---EAKIKKLEDEILVM---DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 282 GHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQ 341
H+ +I L + +++++ +E E+L+ +LE + L++Q +L +QL +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLK---RKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 342 QQVDLQ----RLQQELANE 356
++ +LQ RL E+A +
Sbjct: 1088 KEEELQAALARLDDEIAQK 1106
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/411 (21%), Positives = 182/411 (44%), Gaps = 66/411 (16%)
Query: 4 KKSVSKAGKEL--EVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDE 61
K+++ K +L E++ G K+ V + K+ Q+++L+ + + +R E
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEV--------EHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 62 LAVQEKMFRQEFEQL------ANNKKEIVAFLKRTLNQQVDEITDL--NEQLQNLQLAKE 113
L + + E E + A K +A +L+ Q+ + +L E Q L ++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 114 M-----EKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLL 168
+ E+++ + QL + Q + ++T NI L L++F E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 169 EEQVRK--QENEFRDYAYNLEKKSVLDKDRLRKEIIQRV-------NLVAN------EFH 213
++++ Q+ E + AY+ +K+ K+RL++E+ V LV+N +F
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKT---KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 214 KVTTNRMWETTKRA---------IKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCK 264
++ ++K A +E L +AR ++ ++ +E E R N + K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE----RTNKMLK 1510
Query: 265 -QLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
++E L +++ + ++ +K L + +E + +E E+ L E L+L+V
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQATEDAKLRLEV 1567
Query: 324 DNQALKSQ-------RDQLSLQLEQQ-QVDLQRLQQELANEQKVRASLEAA 366
+ QALK Q RD+ + + +Q Q L + EL +E+K RA AA
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/424 (20%), Positives = 181/424 (42%), Gaps = 58/424 (13%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT----LNQQVDEITDL 101
R L L + QRK+D+L +EK ++ ++ E A K T L + ++E +
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 102 NEQLQ--NLQLAKEMEK-DAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQK 158
E+L+ N L EME + + + + HE +++K L T+ +EE + Q
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----------MEEMKTQL 1548
Query: 159 EEVTDKFTLLEEQVRKQENEFR----DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHK 214
EE+ D+ E+ + E + + +L+ + ++++ R+ +QR + H+
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--LQR------QLHE 1600
Query: 215 VTTNRMWETTKRAI-----KENNG----ITLQMARVSQQGMKLLQENEQLKGRQNNLCKQ 265
T E +RA+ K+ G + LQ + + +++ +L+ + + ++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 266 LELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL------------LLSQ 313
LE ++ + + ++K L + Q+D AE R L S
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL--ANEQKVRASLEAALVQAT 371
L R+ LQ + + L+++ QL +LE++Q +++ + + A +Q + S E A ++T
Sbjct: 1721 LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 372 SFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAACPHQESQSHGP 431
+ + + ++ ++ EM + ST+A K A ++ +
Sbjct: 1780 AQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 432 PKES 435
K++
Sbjct: 1836 EKQA 1839
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/313 (24%), Positives = 127/313 (40%), Gaps = 58/313 (18%)
Query: 61 ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE 120
+L Q K F++E E ++ EI A K + DL + ++L A+ K
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---- 1704
Query: 121 AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR 180
Q E +E ++L + L G+ A +E R LE ++ + E E
Sbjct: 1705 ----QADLEKEELAEELASS---LSGRNALQDEKRR-----------LEARIAQLEEELE 1746
Query: 181 DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR 240
+ N+E S DR+RK Q+ ++NE T + ++N Q+ R
Sbjct: 1747 EEQGNMEAMS----DRVRKAT-QQAEQLSNEL---------ATERSTAQKNESARQQLER 1792
Query: 241 VSQQGMKLLQENE-QLKGRQNNLCKQLEL----LENTQKVMARHKRGHQKIILMLTKKCQ 295
+++ L E E +K + + LE LE + AR K+ K + KK +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 296 EQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR--DQLSLQLEQQQVDLQRLQQEL 353
E +LL ++R + Q QA K QL QLE+ + + QR+
Sbjct: 1853 E------------ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--- 1897
Query: 354 ANEQKVRASLEAA 366
AN +K++ L+ A
Sbjct: 1898 ANRRKLQRELDEA 1910
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/133 (22%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQE 296
++ + ++ K E ++L+ + + L ++ LL+ + +++ + L K QE
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 297 QQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ-QELAN 355
++ E E L + E R QLQ + + + Q L QLE+++ Q+LQ +++
Sbjct: 920 LEEILHEMEAR---LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 356 EQKVRASLEAALV 368
E K++ + LV
Sbjct: 977 EAKIKKLEDEILV 989
Score = 34.3 bits (77), Expect = 0.28
Identities = 57/274 (20%), Positives = 110/274 (40%), Gaps = 53/274 (19%)
Query: 6 SVSKAGKELEVKKKGGKKEPVVAVEPPLA-KEMKEFYHIQIRDLEDRLARYQRKWDELAV 64
+ +A K+ +++K+ +E ++ A ++ K +I LE+ L Q + ++
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 65 QEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLA 124
+ + Q+ EQL+N +A + T + L Q KE+ E + A
Sbjct: 1758 RVRKATQQAEQLSNE----LATERSTAQKNESARQQLERQ------NKELRSKLHEMEGA 1807
Query: 125 QVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAY 184
V+ +F+ T +AALE K LEEQV ++ E
Sbjct: 1808 -VKSKFKST--------------IAALEA----------KIAQLEEQVEQEARE-----K 1837
Query: 185 NLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQ 244
KS+ KD+ KEI+ +V +M E K ++ N Q+ R ++
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVE---------DERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 245 GMKLLQENEQLKGRQNNLCKQLELLENTQKVMAR 278
+E++++ + L ++L+ + + M R
Sbjct: 1889 AE---EESQRINANRRKLQRELDEATESNEAMGR 1919
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 63.5 bits (153), Expect = 4e-10
Identities = 85/379 (22%), Positives = 172/379 (45%), Gaps = 28/379 (7%)
Query: 1 MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD 60
MA K + KE E+ K K++ + L +E + +Q++ D LA + + D
Sbjct: 853 MANMKEEFEKTKE-ELAKTEAKRKELEEKMVTLMQEKNDL-QLQVQAEADSLADAEERCD 910
Query: 61 ELA---VQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAK---EM 114
+L +Q + +E + A +++EI A L + DE ++L + + +L+L E
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 115 EKDAFEAQLAQVRHEF---QETKDQLTTENIILG-GKLAALEEFRLQKEEVTDKFTLLEE 170
EK A E ++ + E ET +LT E L L++ LQ EE DK L +
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD--LQAEE--DKVNTLTK 1026
Query: 171 QVRKQENEFRDYAYNLE--KKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMW--ETTKR 226
K E + D +LE KK +D +R ++++ + L + ++ E K+
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKK 1086
Query: 227 AIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKI 286
E +G+ ++ GM+L ++ ++L+ R L +++E ++ + + +
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 287 ILMLTKKCQEQ--------QQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQ 338
+ ++++ +E + + K E + + LE+ +LQ + L+ + +
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 339 LEQQQVDLQRLQQELANEQ 357
L +Q +LQR++Q+L E+
Sbjct: 1207 LGEQIDNLQRVKQKLEKEK 1225
Score = 49.7 bits (117), Expect = 7e-06
Identities = 88/393 (22%), Positives = 162/393 (41%), Gaps = 70/393 (17%)
Query: 17 KKKGGKKEPVVAVEPPLA--KEMKEFYHIQIRDLEDRLAR-------YQRKWDE------ 61
K KG ++ A+E L+ K +E I DL + AR Y R+ DE
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 62 -LAVQEKMFRQEFEQLANNKKEIV---AFLKRTLNQQVDEITDLNEQLQNLQLAK-EMEK 116
L+ ++ F Q+ E+L +E + + L L + L EQ + Q AK E+++
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 117 DAFEA--QLAQVRHEFQETKDQLTTENIILGGKLAA-LEEFRLQKEEVTDKFTLLEEQVR 173
+A ++AQ R +++ Q T E KLA L++ E V K LE+ +
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 174 KQENEFRDYAYNLEKKSV----LDK-DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAI 228
+ +NE D ++E+ + LDK R +I+ E H + +
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA--------ELEASQ 1475
Query: 229 KENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIIL 288
KE+ ++ ++ ++ + L + E LK NL Q E+ + T+++ KR H
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNL--QQEISDLTEQIAEGGKRIH----- 1528
Query: 289 MLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQR 348
EL + Q+EQ +LQ + ++ LE ++ + R
Sbjct: 1529 -----------------ELEKIKKQVEQEKSELQ-------AALEEAEASLEHEEGKILR 1564
Query: 349 LQQELANEQKVRASLEAALVQATSFLQNILQMH 381
+Q EL +V++ ++ + + + + + H
Sbjct: 1565 IQLEL---NQVKSEVDRKIAEKDEEIDQMKRNH 1594
Score = 47.4 bits (111), Expect = 3e-05
Identities = 76/403 (18%), Positives = 176/403 (43%), Gaps = 27/403 (6%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELA 63
++++SKA E+ + + + + E +E K+ +++D E+ + K L
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEE--LEEAKKKLAQRLQDAEEHVEAVNAKCASLE 1419
Query: 64 VQEKMFRQEFEQLANNKKEIVAFL------KRTLNQQVDEITDLNEQLQNLQLAKEMEKD 117
++ + E E L + + A +R ++ + E E+ A + E
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 118 AFEAQLAQVRHEFQETKDQLTT---ENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRK 174
+ +L ++++ ++E+ DQL T EN L +++ L E + + + +++QV +
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1539
Query: 175 QENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIK-ENNG 233
+++E + A E ++ L+ + + I R+ L N+ ++ E + + + N
Sbjct: 1540 EKSELQ--AALEEAEASLEHEEGK---ILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 234 ITLQMARVSQQGMKLLQENE--QLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLT 291
I + + S ++ N+ +LK + ++E+ N MA + + +
Sbjct: 1595 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 292 KKCQEQQQDT-KEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQ---LEQQQVD-- 345
K Q D + E+L+ L+ +E+R+ LQ + + L++ +Q EQ+ +D
Sbjct: 1655 KDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1714
Query: 346 --LQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEED 386
+Q L + + + LE + Q +++I+Q R+ E+
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE 1757
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/322 (20%), Positives = 135/322 (41%), Gaps = 45/322 (13%)
Query: 120 EAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEF 179
E ++A ++ EF++TK++L + +++E+ +K L QE
Sbjct: 850 EKEMANMKEEFEKTKEELA--------------KTEAKRKELEEKMVTL-----MQEKND 890
Query: 180 RDYAYNLEKKSVLDKDRLRKEIIQ-RVNLVANEFHKVTTNRMWETTKRAIKE---NNGIT 235
E S+ D + ++I+ ++ L A ++ E T+RA E N +T
Sbjct: 891 LQLQVQAEADSLADAEERCDQLIKTKIQLEA---------KIKEVTERAEDEEEINAELT 941
Query: 236 LQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK--- 292
+ ++ + +L ++ + L+ + K+ EN K + G + I LTK
Sbjct: 942 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
Query: 293 ---KCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDN-QALKSQRDQLSLQLEQQ----QV 344
+ +Q D +AEE ++ + L+ QVD+ + Q ++ + LE+ +
Sbjct: 1002 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG 1061
Query: 345 DLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQL 404
DL+ Q+ + + + L+ L + F + LQ + E++ + + Q KE+ ++
Sbjct: 1062 DLKLAQESTMDIENDKQQLDEKL-KKKEFEMSGLQ-SKIEDEQALGMQLQKKIKELQARI 1119
Query: 405 LVMLSSTVATRPQKAACPHQES 426
+ A R +A Q S
Sbjct: 1120 EELEEEIEAERASRAKAEKQRS 1141
>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
Length = 688
Score = 63.5 bits (153), Expect = 4e-10
Identities = 67/341 (19%), Positives = 147/341 (43%), Gaps = 29/341 (8%)
Query: 49 EDRLARYQRKWDELAVQEK---MFRQEFEQLANNKKEIVAFLKRTLNQ----------QV 95
+D+L +Q+ +L V + + Q+F + + I+ L++ L Q +V
Sbjct: 183 KDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKV 242
Query: 96 DEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFR 155
+E+T++ E LQ KE + + + Q+ + + I L + + R
Sbjct: 243 EELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLR 302
Query: 156 LQKEEVTDKFTLLEEQVRKQENEFRDYAY------------NLEKKSVLDKDRLRKEIIQ 203
+ + + L+ + + ENE + NL+K L +++ ++E I+
Sbjct: 303 TENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIE 362
Query: 204 RVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLC 263
++ + F + T R T K +Q++R++++ L E + +G+ +
Sbjct: 363 KMKETVSRFVQDATIR---TKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVI 419
Query: 264 KQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQV 323
K+ + +E + + R RG++ L + Q + ++L+L L++ E R QL+
Sbjct: 420 KEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLET 479
Query: 324 DNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLE 364
D+ + R Q +Q Q ++ +R L +EQ+++ E
Sbjct: 480 DSSE-EISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQE 519
Score = 42.0 bits (97), Expect = 0.001
Identities = 81/403 (20%), Positives = 173/403 (42%), Gaps = 54/403 (13%)
Query: 1 MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMK-EFYHIQIRDLEDRLARYQRKW 59
+A + ++ ++L+ + K +K+ V A A + + + I+ LE RL ++
Sbjct: 239 VAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEA 298
Query: 60 DELAVQ----EKMFRQ---EFEQLANNKKEIVAFLKRTLN-------QQVDEITDLNEQL 105
++L + EK R+ + +L N + E + + ++ Q+ + + ++
Sbjct: 299 NQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKE 358
Query: 106 QNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE----EFRLQKEEV 161
++++ KE + + + E TK Q + L +L+AL+ E + Q E V
Sbjct: 359 EDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERV 418
Query: 162 TDKFTLLEEQVRKQENEFRDYAYNLEK-----KSVLDKDRLRKEIIQRVNLVANEFHKVT 216
+ +EE++ K E R + K + L +R + ++ R+ N ++
Sbjct: 419 IKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLE 478
Query: 217 TNRMWETTK------------RAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCK 264
T+ E ++ + +EN G+ VS+Q +KL QEN+QL+ +L K
Sbjct: 479 TDSSEEISRYQEMIQKLQNVLESERENCGL------VSEQRLKLQQENKQLRKETESLRK 532
Query: 265 QLELLENTQKVMARHKRGHQKIILM---LTKKCQEQQQDTKEA-EELRLLLSQLEQRSLQ 320
LE +K + + + + +E + + + ELR LL+ ++ + +
Sbjct: 533 --IALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANR 590
Query: 321 LQVDNQALKSQRD----QLSLQLEQQQVDLQRL--QQELANEQ 357
+ + + L + L +L +Q++ Q L Q E+ANE+
Sbjct: 591 WKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEK 633
Score = 32.0 bits (71), Expect = 1.4
Identities = 65/300 (21%), Positives = 117/300 (39%), Gaps = 53/300 (17%)
Query: 71 QEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVR-HE 129
QE QLAN +K L +T++Q++D + L ++ E + FE+Q + + +
Sbjct: 134 QEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMT-----EAQIHVFESQKQKDQLFD 188
Query: 130 FQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKK 189
FQ+ QL N + EVT+ +Q K E L KK
Sbjct: 189 FQQLTKQLHVTN---------------ENMEVTN------QQFLKTVTEQSVIIEQLRKK 227
Query: 190 SVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLL 249
K LR + + E VT + + K KE + ++ R +L
Sbjct: 228 LRQAKLELRVAVAK-----VEELTNVTEDLQGQMKK---KEKDVVSAH-GREEASDRRLQ 278
Query: 250 QENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRL 309
Q +K + LC ++ + R + H L K+ +E Q E E R
Sbjct: 279 QLQSSIKQLEIRLCVTIQ-----EANQLRTENTH------LEKQTRELQAKCNELENERY 327
Query: 310 LLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELA---NEQKVRASLEAA 366
+ S+QL + Q+ Q L+ +Q++ D++++++ ++ + +R E A
Sbjct: 328 EAIVRARNSMQLL---EEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVA 384
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 62.8 bits (151), Expect = 7e-10
Identities = 83/380 (21%), Positives = 169/380 (44%), Gaps = 30/380 (7%)
Query: 1 MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD 60
MA K + KE E+ K K++ + L +E + +Q++ D LA + + D
Sbjct: 853 MANMKEEFEKTKE-ELAKTEAKRKELEEKMVTLMQEKNDL-QLQVQAEADALADAEERCD 910
Query: 61 ELA---VQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAK---EM 114
+L +Q + +E + A +++EI A L + DE ++L + + +L+L E
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 115 EKDAFEAQLAQVRHEF---QETKDQLTTENIILG-GKLAALEEFRLQKEEV---TDKFTL 167
EK A E ++ + E ET +LT E L L++ ++++++V T T
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 168 LEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRA 227
LE+QV E EKK +D +R ++++ + L ++ K
Sbjct: 1031 LEQQVDDLEGSLEQ-----EKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLK 1085
Query: 228 IKENNGITLQMARVSQQGM--KLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQK 285
KE LQ +Q + +L ++ ++L+ R L +++E ++ + + +
Sbjct: 1086 KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 286 IILMLTKKCQEQ--------QQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSL 337
+ ++++ +E + + K E + + LE+ +LQ + AL+ +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVA 1205
Query: 338 QLEQQQVDLQRLQQELANEQ 357
+L +Q LQR++Q+L E+
Sbjct: 1206 ELGEQIDSLQRVKQKLEKEK 1225
Score = 47.0 bits (110), Expect = 4e-05
Identities = 80/428 (18%), Positives = 166/428 (38%), Gaps = 62/428 (14%)
Query: 12 KELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQ 71
+E E +K E A +++ + + +L +++ QR +L ++ +
Sbjct: 1171 REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKM 1230
Query: 72 EFEQLANNKKEI----VAFLK--RTLNQQVDEITDLNEQLQNL----------------Q 109
E LA+N + + F K RTL Q+ EI E+ Q L +
Sbjct: 1231 EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE 1290
Query: 110 LAKEM-EKDAFEAQLAQVRHEF----QETKDQLTTENIILGGKLAALEE-------FRLQ 157
++++ EKDA +QL++ + F +E K QL E AL+ R Q
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 158 KEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRL---RKEIIQRVNLVANEFHK 214
EE + L+ + K +E + E ++ + L +K++ QR+ A E +
Sbjct: 1351 YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ-DAEEHVE 1409
Query: 215 VTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQK 274
++ K + N + M V + + +++ + L + + E TQ
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA 1469
Query: 275 VMARHKR--------------------GHQKIILMLTKKCQEQQQD-TKEAEELRLLLSQ 313
+ ++ H + + K Q++ D T++ E + +
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHE 1529
Query: 314 LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSF 373
LE+ QL + L++ ++ LE ++ + R+Q EL +V++ ++ + +
Sbjct: 1530 LEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL---NQVKSEIDRKIAEKDEE 1586
Query: 374 LQNILQMH 381
L + + H
Sbjct: 1587 LDQLKRNH 1594
Score = 40.8 bits (94), Expect = 0.003
Identities = 62/322 (19%), Positives = 132/322 (40%), Gaps = 45/322 (13%)
Query: 120 EAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEF 179
E ++A ++ EF++TK++L + +++E+ +K L QE
Sbjct: 850 EKEMANMKEEFEKTKEELA--------------KTEAKRKELEEKMVTL-----MQEKND 890
Query: 180 RDYAYNLEKKSVLDKDRLRKEIIQ-RVNLVANEFHKVTTNRMWETTKRAIKE---NNGIT 235
E ++ D + ++I+ ++ L A ++ E T+RA E N +T
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEA---------KIKEVTERAEDEEEINAELT 941
Query: 236 LQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK--- 292
+ ++ + +L ++ + L+ + K+ EN K + G + I LTK
Sbjct: 942 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
Query: 293 ---KCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDN-QALKSQRDQLSLQLEQQ----QV 344
+ +Q D + EE ++ + L+ QVD+ + Q +L + LE+ +
Sbjct: 1002 ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG 1061
Query: 345 DLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQL 404
DL+ Q+ + + + L L + + N+ + E++ + + Q KE+ ++
Sbjct: 1062 DLKLAQESTMDTENDKQQLNEKLKKKEFEMSNL--QGKIEDEQALAIQLQKKIKELQARI 1119
Query: 405 LVMLSSTVATRPQKAACPHQES 426
+ A R +A Q S
Sbjct: 1120 EELEEEIEAERASRAKAEKQRS 1141
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 62.4 bits (150), Expect = 1e-09
Identities = 81/395 (20%), Positives = 170/395 (43%), Gaps = 32/395 (8%)
Query: 14 LEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEF 73
L+ K + +K + V+ + E KE +++ L + + + +L+ ++F +
Sbjct: 656 LKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK 715
Query: 74 EQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQET 133
E + KE + L++ L V+E +LN+ L+N Q+ K K L ++ E E
Sbjct: 716 EDVI--LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSED 773
Query: 134 KDQLTTENII--LGGKLAALEE----FRLQKE----EVTDKFTLLEEQVRKQENEFRDYA 183
++ N++ +G LA + E Q++ E+ + L+E+ Q E +
Sbjct: 774 SEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLL 833
Query: 184 YNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTN--RMWETTKRAIKENNGITLQMARV 241
+ E++ VL LRKE+ + + +E + ++ M ++ EN + +Q+ V
Sbjct: 834 RDYEQEKVL----LRKELEE----IQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEV 885
Query: 242 SQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIIL--MLTKKCQEQQQ 299
SQ K NE ++ K+ E L+ + R + I+L L K +
Sbjct: 886 SQTCSKSEIHNE----KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKND 941
Query: 300 DTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL----AN 355
+EL + LE+ + + +K + +L+ + + Q +++EL +
Sbjct: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Query: 356 EQKVRASLEAALVQATSFLQNILQMHRDEEDSDVD 390
+ ++ AS+ + A S+ +L+ + E DV+
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE 1036
Score = 57.4 bits (137), Expect = 3e-08
Identities = 107/450 (23%), Positives = 186/450 (41%), Gaps = 68/450 (15%)
Query: 9 KAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKM 68
KA KEL+ +K + V E + K+ +RDL Y+ E Q +
Sbjct: 976 KAKKELDSSRK---ETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 1032
Query: 69 FRQEFEQLANNKKEIVAFLKRTLNQ---QVDEITDLNEQL----QNLQL-AKEMEKDAFE 120
E E+ ANN + + L R L Q + I NE L + LQ AK +E E
Sbjct: 1033 LDVEKER-ANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 1091
Query: 121 AQLAQVRHEFQETKDQLTTENIIL--GGKLAALEEFR--LQKEEVTDKFTLLEEQVRKQE 176
Q A+ + + ++L E I + LEE + LQKE+ + T+ E ++ K++
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 177 NEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITL 236
+ L + D +RL KE+ Q++ N+ +K+ E ++ IK I
Sbjct: 1152 AQ----QTTLMNMEIADYERLMKELNQKLT---NKNNKI------EDLEQEIK----IQK 1194
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILM---LTKK 293
Q Q+ + LQ + Q +N KQL L T+K +A K+ +++ L +
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQL--LVKTKKELADSKQAETDHLILQASLKGE 1252
Query: 294 CQEQQQDTK----------------------EAEELRLLLSQLEQRSLQLQVDNQALKSQ 331
+ QQ + AE+ + LS +QR LQ + +A K++
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE 1312
Query: 332 RDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDV 391
+ ++ + E +V + + ++ N+ +A E A + I Q+ +DS ++
Sbjct: 1313 QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 392 --------TFQPWHKEMLQQLLVMLSSTVA 413
T Q H +L++ ML TV+
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVS 1402
Score = 48.9 bits (115), Expect = 1e-05
Identities = 98/478 (20%), Positives = 197/478 (41%), Gaps = 84/478 (17%)
Query: 6 SVSKAG---KELE------VKKKGGKKEPVVAVEPP-------LAKEMKEFYHIQIRDLE 49
SV+K G KELE VK+ K ++AV L K+++E + Q+ +L
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQL-ELS 167
Query: 50 DRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQ 109
++L D + K ++E E++ +E + +L++ L+ DE + QLQN+
Sbjct: 168 EQLKFQNNSEDNV----KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNII 223
Query: 110 LAK----EMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKF 165
A + ++ + +L Q++ QE +L + +E + E +K
Sbjct: 224 EANSQHYQKNINSLQEELLQLKAIHQEEVKEL----------MCQIEASAKEHEAEINKL 273
Query: 166 TLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRK------------EIIQRVNLVANEFH 213
L+E + KQ N++KK + + LRK I+ + N +
Sbjct: 274 NELKENLVKQCEASEK---NIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
Query: 214 KVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQ 273
+ +T K +++ + ++ ++ +KL + + +K + + LE N +
Sbjct: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN-E 389
Query: 274 KVMARHKRG------HQKIILMLTKKCQEQQQDTKEAEELR------------LLLSQLE 315
++A+ ++G ++ + + C +Q +E + L+ LS E
Sbjct: 390 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSE 449
Query: 316 QRSLQLQVDNQALKSQRDQLS-------LQLEQQQVDLQRLQQELANEQ-KVRASLEAAL 367
+ L L + Q LK Q + L L E + ++ LQ EL K+ E+
Sbjct: 450 KEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMK 509
Query: 368 VQATSFLQNILQMHR---DEEDSDVDVT--FQPWHKEML--QQLLVMLSSTVATRPQK 418
Q S + + Q R E+D+ ++ Q ++++L Q+L+ L +T+ +K
Sbjct: 510 QQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK 567
Score = 47.4 bits (111), Expect = 3e-05
Identities = 79/389 (20%), Positives = 162/389 (41%), Gaps = 59/389 (15%)
Query: 44 QIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNE 103
+++ LED L EL Q + + E + N K ++ + ++ E DL
Sbjct: 333 KVKHLEDTLK-------ELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEF 385
Query: 104 QLQNLQLAKEMEKDAFE---AQLAQVRHEFQETKDQLTTENIILGGK----LAALEEFRL 156
++ L LAKE + E ++LA + +F T +Q E L + ++ L E L
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
Query: 157 ---QKEEVTDKFTL--LEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANE 211
+KE++T F + L+EQ + E ++ N E + + L+ E+ + ++ E
Sbjct: 446 SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREI-MEILQTELGESAGKISQE 504
Query: 212 FHKVT------TNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNL--- 262
F + + + + + A E + + + R+ + KLL + E + +N +
Sbjct: 505 FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
Query: 263 -----------------CKQLE-----LLENTQKVMARHKRGHQKIILMLTKKCQEQQQD 300
K+LE L E + + K H+++ KKC+ +++
Sbjct: 565 QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD-NFHKKCEREERL 623
Query: 301 T----KEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANE 356
K+ E+ S+LEQ+ +L + ++DQ +LE+ V ++ L ++ +
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED---K 680
Query: 357 QKVRASLEAALVQATSFLQNILQMHRDEE 385
+ + A +++ + Q+ RD E
Sbjct: 681 EVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/364 (21%), Positives = 165/364 (45%), Gaps = 29/364 (7%)
Query: 38 KEFYHIQIRDLEDRLARYQRKWDELA---VQEKMFRQEFEQLANNKKEIVAFLKRTLNQQ 94
K +Q++ +D LA + + D+L +Q + +E + +++E+ A L +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 95 VDEITDLNEQLQNLQLAK---EMEKDAFEAQLAQVRHEF---QETKDQLTTENIILG-GK 147
DE ++L + +L+L E EK A E ++ + E E +LT E L
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 148 LAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLE--KKSVLDKDRLRKEIIQRV 205
AL++ LQ EE DK L + K E + D +LE KK +D +R ++++ +
Sbjct: 1004 QQALDD--LQAEE--DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1059
Query: 206 NLVANEFHKVTTNRMW--ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLC 263
L + ++ E K+ E N + ++ G +L ++ ++L+ R L
Sbjct: 1060 KLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 264 KQLELLENTQKVMARHKRGHQKIILMLTKKCQEQ--------QQDTKEAEELRLLLSQLE 315
++LE + + + + + + ++++ +E + + K E + + LE
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 316 QRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQ 375
+ +LQ + AL+ + +L +Q +LQR++Q+L +K ++ + L TS ++
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL---EKEKSEFKLELDDVTSNME 1236
Query: 376 NILQ 379
I++
Sbjct: 1237 QIIK 1240
Score = 48.9 bits (115), Expect = 1e-05
Identities = 87/441 (19%), Positives = 174/441 (39%), Gaps = 76/441 (17%)
Query: 12 KELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQ 71
+E E +K E A +++ + + +L +++ QR +L ++ F+
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1226
Query: 72 EFEQLANNKKEIVAF------LKRTLNQQVDE-----------ITDLNEQLQNLQ----- 109
E + + +N ++I+ + RTL Q++E + DL Q LQ
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 110 LAKEM-EKDAFEAQLAQVR----HEFQETKDQLTTENIILGGKLAALEE-------FRLQ 157
L++++ EK+A +QL + + + ++ K QL E AL+ R Q
Sbjct: 1287 LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ 1346
Query: 158 KEEVTDKFTLLEEQVRKQENEFRDYAYNLE-------------KKSVLDKDRLRKEIIQR 204
EE T+ L+ + K +E + E KK + + + +E ++
Sbjct: 1347 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 205 VNLVANEFHKVTTNRMW---ETTKRAIKENNGITLQMARVSQQGMKLLQENEQ------- 254
VN + K T +R+ E ++ +N + + + K+L E +Q
Sbjct: 1407 VNAKCSSLEK-TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 255 -LKGRQN---NLCKQLELLENTQKVMARH----KRGHQKIILMLTKKCQEQQQDTKEAEE 306
L+ Q +L +L L+N + H KR ++ + ++ ++ K E
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 307 LRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAA 366
L + QLE ++LQ S ++ LE ++ + R Q E +++A +E
Sbjct: 1526 LEKVRKQLEAEKMELQ-------SALEEAEASLEHEEGKILRAQLEF---NQIKAEIERK 1575
Query: 367 LVQATSFLQNILQMHRDEEDS 387
L + ++ + H DS
Sbjct: 1576 LAEKDEEMEQAKRNHLRVVDS 1596
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/377 (23%), Positives = 151/377 (40%), Gaps = 83/377 (22%)
Query: 47 DLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKR----TL--NQQVDEITD 100
DL+D++A Q + DEL +Q LA ++E+ L R TL N + + +
Sbjct: 1066 DLQDQIAELQAQIDELKLQ----------LAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 101 LNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKE- 159
L Q+ LQ E EK A + + + + E + L TE AA +E R ++E
Sbjct: 1116 LQAQIAELQEDFESEK-ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
Query: 160 EVTDKFTLLEEQVRKQENEFRD---------------------YAYNLEKK--------- 189
EV + LEE+ + E + +D + NLEK
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 190 --------------------------------SVLDKDRLRKEIIQRVNLVANEFHKVTT 217
V + DRLR E+ ++ + + NE V+T
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 218 NRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMA 277
+ E K+ IK +++ Q +LLQE + K ++ +QLE +N+ +
Sbjct: 1295 -LLEEAEKKGIKFAKDAASLESQL-QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 278 RHKRGHQKIILMLTKKCQEQQQDTKEAEELRL-LLSQLEQRSLQLQVDNQALKSQRDQLS 336
+ +K + Q Q DTK+ + L + LE+ +L D +AL + ++ +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 337 LQLEQQQVDLQRLQQEL 353
L ++ + RLQQEL
Sbjct: 1413 LAYDKLEKTKNRLQQEL 1429
Score = 61.6 bits (148), Expect = 2e-09
Identities = 96/435 (22%), Positives = 180/435 (41%), Gaps = 65/435 (14%)
Query: 10 AGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMF 69
A +EL K++ + V ++ L +E K + QI+D+ R A + E Q K F
Sbjct: 1164 AQQELRTKRE----QEVAELKKALEEETKN-HEAQIQDMRQRHATALEELSEQLEQAKRF 1218
Query: 70 RQEFEQ----LANNKKEI---VAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQ 122
+ E+ L + KE+ V L++ + + L+ Q+Q L AK E D +
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH-AKVSEGDRLRVE 1277
Query: 123 LAQVRHEFQETKDQLTT------ENIILGGKLAALEEFRLQ------KEEVTDKFTLLEE 170
LA+ + Q D ++T + I K AA E +LQ +EE K L
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL-SS 1336
Query: 171 QVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKV-----TTNRMWETTK 225
++R+ E E E++ K+ L K+++ + +A+ KV T + E K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKN-LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 226 RAIKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLEL-------LENTQKVMAR 278
+ +K+ ++ ++ + KL + +L+ ++L L+ LE QK +
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 279 HKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLS-----------QLEQRSLQLQVDNQA 327
+ I ++ + + +E E L L+ + E+++ QL+ D +
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 328 LKSQRDQ--------------LSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSF 373
L S +D L Q+E+ + L+ L+ EL + + LE + +
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 374 LQNILQMHRDEEDSD 388
+ LQ RDE++ +
Sbjct: 1576 FERDLQT-RDEQNEE 1589
Score = 58.9 bits (141), Expect = 1e-08
Identities = 93/394 (23%), Positives = 154/394 (39%), Gaps = 71/394 (18%)
Query: 43 IQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLN 102
+ I DLE+RL + E+ RQE E+ KR L+ E TDL
Sbjct: 1034 VMISDLEERLKK-----------EEKTRQELEK-----------AKRKLD---GETTDLQ 1068
Query: 103 EQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVT 162
+Q+ LQ + D + QLA+ E Q + E + L + E + Q E+
Sbjct: 1069 DQIAELQ----AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 163 DKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWE 222
+ F + K E + RD + LE +D L Q+ E + E
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ------ELRTKREQEVAE 1178
Query: 223 TTKRAIKENNGITLQMARVSQQGMKLLQE----NEQLKGRQNNLCKQLELLENTQKVMAR 278
K +E Q+ + Q+ L+E EQ K + NL K + LE K +A
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 279 HKRGHQKIIL-------MLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDN------ 325
+ Q++ L + QE E + LR+ L++ + LQ ++DN
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE-KASKLQNELDNVSTLLE 1297
Query: 326 ----QALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLEAALVQATSFLQNILQMH 381
+ +K +D S LE Q D Q L QE E + + +L + + Q ++ +
Sbjct: 1298 EAEKKGIKFAKDAAS--LESQLQDTQELLQE---ETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 382 RDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATR 415
+EE++ K + +Q+L + S T+
Sbjct: 1353 EEEEEA---------RKNLEKQVLALQSQLADTK 1377
Score = 53.1 bits (126), Expect = 6e-07
Identities = 83/390 (21%), Positives = 176/390 (45%), Gaps = 65/390 (16%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHI--QIRDLEDRLARYQRKWDE 61
K+ +K ELE ++ K + ++ + LA++++ + + ++ RLA +++ +E
Sbjct: 865 KEKQTKVEGELEEMER--KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 62 LA------VQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEME 115
+ V+E+ +E Q+ N+K+ + + L +Q+DE ++LQ +E
Sbjct: 923 ILHDLESRVEEE---EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ-------LE 972
Query: 116 KDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQ 175
K EA++ ++ E +DQ + +F +K+ + D+ Q+ ++
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNS--------------KFIKEKKLMEDRIAECSSQLAEE 1018
Query: 176 ENEFRDYAYNLEKKSVLDKD---RLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENN 232
E + ++ A K+ V+ D RL+KE R E K ETT +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTR-----QELEKAKRKLDGETTDL----QD 1069
Query: 233 GITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK 292
I A++ + ++L ++ E+L+G L + + HK K++ L
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQG---------ALARGDDETL--HKNNALKVVRELQA 1118
Query: 293 KCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQ-RDQLSLQLEQQQVDLQRLQQ 351
+ E Q+D + + R ++ E++ L + +ALK++ D L QQ++ +R +Q
Sbjct: 1119 QIAELQEDFESEKASR---NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR-EQ 1174
Query: 352 ELANEQKVRASLEAALVQATSFLQNILQMH 381
E+A +++ +LE + +Q++ Q H
Sbjct: 1175 EVA---ELKKALEEETKNHEAQIQDMRQRH 1201
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/342 (23%), Positives = 154/342 (45%), Gaps = 41/342 (11%)
Query: 48 LEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVD---EITDLNEQ 104
L++ L +E + F ++ L + ++ L+ Q+++ I L E+
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 105 LQNLQLAKEMEKDA---FEAQLAQVRHEFQETK----DQLTTENIILGGKLAALEEFRLQ 157
+LQ +E E++A E Q+ ++ + +TK D L T + K L++
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404
Query: 158 KEEVTDK---FTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHK 214
+ + +K + LE+ + + E D +L+ + + + L K+ + L+A E K
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN-LEKKQKKFDQLLAEE--K 1461
Query: 215 VTTNRMWETTKRA---IKENNGITLQMARVSQQGMKLLQENEQLKGRQNN-LCKQLELLE 270
+ R E RA +E L +AR ++ ++ +E E RQN L +E L
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE----RQNKQLRADMEDLM 1517
Query: 271 NTQKVMARHKRGHQKIILMLTKKCQEQQQDTK--EAEELRLLLSQLEQRSLQLQVDNQAL 328
+++ + ++ +K +K+ EQQ + + EEL L E L+L+V+ QA+
Sbjct: 1518 SSKDDVGKNVHELEK-----SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 329 KSQRDQLSLQLEQQQVD---------LQRLQQELANEQKVRA 361
K+Q ++ LQ +Q + ++ L+ EL +E+K RA
Sbjct: 1573 KAQFER-DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Score = 48.1 bits (113), Expect = 2e-05
Identities = 62/268 (23%), Positives = 123/268 (45%), Gaps = 37/268 (13%)
Query: 97 EITDLNEQLQ--NLQLAKEMEKDA-FEAQLAQVRHEFQETKDQLTTENIILGGKLAALEE 153
++T E+LQ + +L K EK E +L ++ + Q QL E IL +L A E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQ----QLLEEKNILAEQLQAETE 901
Query: 154 FRLQKEEVTDKFTLLEEQV---------RKQENEFRDYAYNLEKKSVLD-----KDRLRK 199
+ EE+ + ++++ R +E E R+ EKK + +++L +
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 200 EIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQ 259
E R L + KVT E + ++E ++ + Q K ++E + ++ R
Sbjct: 962 EEGARQKL---QLEKVTA----EAKIKKMEE------EILLLEDQNSKFIKEKKLMEDRI 1008
Query: 260 NNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSL 319
QL E K +A+ + + +I L ++ +++++ +E E+ + +L+ +
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK---RKLDGETT 1065
Query: 320 QLQVDNQALKSQRDQLSLQLEQQQVDLQ 347
LQ L++Q D+L LQL +++ +LQ
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQ 1093
Score = 47.8 bits (112), Expect = 2e-05
Identities = 83/379 (21%), Positives = 170/379 (44%), Gaps = 34/379 (8%)
Query: 4 KKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHI--QIRDLEDRLARYQRKWDE 61
K S+ + +E E +K +K+ V+A++ LA K+ I LE+ + + +
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQ-VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 62 LAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEIT-DLNEQLQ---NLQLAKEMEKD 117
L+ R E + LA +K E K L Q++D++T DL+ Q Q NL+ K+ + D
Sbjct: 1404 LSQ-----RLEEKALAYDKLEKT---KNRLQQELDDLTVDLDHQRQVASNLE-KKQKKFD 1454
Query: 118 AFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQEN 177
A+ + + E +D+ E K +L + E ++F +Q+R
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 178 EFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTN-RMWETTKRAIKENNGITL 236
+ ++ K +V + ++ ++ + Q+V + + ++ + E K ++ N
Sbjct: 1515 DLMSSKDDVGK-NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN----- 1568
Query: 237 QMARVSQQGMKLLQENEQLKGRQNNLCKQL-EL---LENTQKVMARHKRGHQKIILMLTK 292
A +Q L +EQ + ++ L KQ+ EL LE+ +K A +K+ + L
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 293 KCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQ-------LEQQQVD 345
+ + K +E+ L +L+ + Q + + ++ RD++ Q L+ + +
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Query: 346 LQRLQQELANEQKVRASLE 364
+ +LQ+ELA+ ++ R E
Sbjct: 1689 ILQLQEELASSERARRHAE 1707
Score = 45.8 bits (107), Expect = 9e-05
Identities = 83/376 (22%), Positives = 150/376 (39%), Gaps = 78/376 (20%)
Query: 46 RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT----LNQQVDEITDL 101
R + L + Q+K+D+L +EK + + ++ E A K T L + ++E +
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 102 NEQL--QNLQLAKEME-------------------KDAFEAQLAQVRHEFQETKDQL-TT 139
E+ QN QL +ME K A E Q+ ++R + +E +D+L T
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 140 ENIIL-------GGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRD------YAYNL 186
E+ L K + + + E+ +K LL +QVR+ E E D A
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 187 EKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGM 246
+KK +D L +I + N +E IK+ + QM ++
Sbjct: 1619 KKKMEIDLKDLEAQI-EAANKARDE---------------VIKQLRKLQAQMKDYQRELE 1662
Query: 247 KLLQENEQLKGRQNNLCKQLELLE----NTQKVMARHKRGHQKIILMLTKKCQEQQQD-- 300
+ +++ + K+L+ LE Q+ +A +R ++ EQ++D
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA---------RRHAEQERDEL 1713
Query: 301 ----TKEAEELRLLLSQ---LEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQEL 353
T A LL + LE R QL+ + + +S + L+ + + + + L EL
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 354 ANEQKVRASLEAALVQ 369
A E+ + A Q
Sbjct: 1774 AAERSAAQKSDNARQQ 1789
Score = 43.1 bits (100), Expect = 6e-04
Identities = 36/181 (19%), Positives = 88/181 (48%), Gaps = 10/181 (5%)
Query: 246 MKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKII---LMLTKKCQEQQQDTK 302
+++ ++ E+L+ + L K E + + +R HQ+++ +L ++ Q + +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 303 EAEELRLLLSQLEQRSLQLQVDNQALKSQRDQ----LSLQLEQQQVDLQRLQQELANEQK 358
EAEE+R L+ +Q ++ D ++ + ++ L + ++ Q +Q L+++L E+
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 359 VRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQK 418
R L+ V A + ++ + + ED + + K++++ + SS +A +K
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE---KKLMEDRIAECSSQLAEEEEK 1021
Query: 419 A 419
A
Sbjct: 1022 A 1022
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 62.0 bits (149), Expect = 1e-09
Identities = 76/386 (19%), Positives = 167/386 (43%), Gaps = 61/386 (15%)
Query: 33 LAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLN 92
+ +E++ + R+L++ + +Y+ +++L + + EFE I+ K
Sbjct: 122 IQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYE 181
Query: 93 QQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE 152
++ + + E+L+N L ++ KD+ + +QL E + L KL LE
Sbjct: 182 SEIARLEEDKEELRNQLLNVDLTKDS-------------KRVEQLAREKVYLCQKLKGLE 228
Query: 153 ----EFRLQKE----EVTDKFTLLEEQVRKQENEFRDYAYNLEKKSV-LDKDRLRKEI-- 201
E + +KE +V + + Q+ + + R + EK+S L +RL KE+
Sbjct: 229 AEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVR--SLEAEKQSANLRAERLEKELQS 286
Query: 202 -IQRVNLVANEFHKVTTNRMWETTK-RAIKENN-----GITLQMARVSQQGMKLLQENEQ 254
++ + N+ HK ++K + +K +N I L+ AR + L +E +
Sbjct: 287 SSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSE---LERERNK 343
Query: 255 LKGRQNNLCKQLELL----------------ENTQKVMARHKRGHQKIILMLTKKCQEQQ 298
++ + L E+L E +KV A + G+QK++++ +K E +
Sbjct: 344 IQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL-ELE 402
Query: 299 QDTKEAEELRL--------LLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ 350
+ E++++ Q E++ Q+ + + + + L+L+QQ V ++ +
Sbjct: 403 NRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAE 462
Query: 351 QELANEQKVRASLEAALVQATSFLQN 376
+E ++ + + +Q TS Q+
Sbjct: 463 KEKNENSDLKQQISSLQIQVTSLAQS 488
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 62.0 bits (149), Expect = 1e-09
Identities = 76/386 (19%), Positives = 167/386 (43%), Gaps = 61/386 (15%)
Query: 33 LAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRTLN 92
+ +E++ + R+L++ + +Y+ +++L + + EFE I+ K
Sbjct: 122 IQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYE 181
Query: 93 QQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE 152
++ + + E+L+N L ++ KD+ + +QL E + L KL LE
Sbjct: 182 SEIARLEEDKEELRNQLLNVDLTKDS-------------KRVEQLAREKVYLCQKLKGLE 228
Query: 153 ----EFRLQKE----EVTDKFTLLEEQVRKQENEFRDYAYNLEKKSV-LDKDRLRKEI-- 201
E + +KE +V + + Q+ + + R + EK+S L +RL KE+
Sbjct: 229 AEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVR--SLEAEKQSANLRAERLEKELQS 286
Query: 202 -IQRVNLVANEFHKVTTNRMWETTK-RAIKENN-----GITLQMARVSQQGMKLLQENEQ 254
++ + N+ HK ++K + +K +N I L+ AR + L +E +
Sbjct: 287 SSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSE---LERERNK 343
Query: 255 LKGRQNNLCKQLELL----------------ENTQKVMARHKRGHQKIILMLTKKCQEQQ 298
++ + L E+L E +KV A + G+QK++++ +K E +
Sbjct: 344 IQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKL-ELE 402
Query: 299 QDTKEAEELRL--------LLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQ 350
+ E++++ Q E++ Q+ + + + + L+L+QQ V ++ +
Sbjct: 403 NRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAE 462
Query: 351 QELANEQKVRASLEAALVQATSFLQN 376
+E ++ + + +Q TS Q+
Sbjct: 463 KEKNENSDLKQQISSLQIQVTSLAQS 488
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 61.6 bits (148), Expect = 2e-09
Identities = 86/400 (21%), Positives = 187/400 (46%), Gaps = 45/400 (11%)
Query: 23 KEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLA--NNK 80
K+ + + LA+++K+ Q+ D ++ LA +R +++ +QE++ R + E A +
Sbjct: 431 KDDEINQQSQLAEKLKQ----QMLDQDELLASTRRDYEK--IQEELTRLQIENEAAKDEV 484
Query: 81 KEIVAFLKRTL------NQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETK 134
KE++ L+ +Q+V++ T NEQL + K + +L+Q++ K
Sbjct: 485 KEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQK 544
Query: 135 DQLTTE-NIIL------GGKLAALEEFRLQKEE--VTDKFTLLEEQVRKQENEFRDYAYN 185
+ T N++L GG + + L + ++FT+ + K ++E +
Sbjct: 545 KRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNR 604
Query: 186 LEKKSVLDKDRLRKEIIQRVNLVANEFH--------KVTTNRM--WETTKRAIKEN-NGI 234
++ D RK L A + K T+ M E +R ++E+ + +
Sbjct: 605 SKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSL 664
Query: 235 TLQMARV-SQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKK 293
+ ++A++ +Q+ M + ++ K L E+ + ++ M H+ HQK + L +
Sbjct: 665 SEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDE 724
Query: 294 CQEQQQDTKEAEELRLLLSQLEQRSL-----QLQVDNQALKSQRDQLSL---QLEQQQVD 345
+E+Q+ E +L L QLEQ L +L++++Q + + ++L L + EQ + D
Sbjct: 725 IEEKQKIIDEIRDLNQKL-QLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQARED 783
Query: 346 LQRLQQELANEQKVRASLEAALVQ-ATSFLQNILQMHRDE 384
L+ L++ ++ E + +L VQ T+ ++ +++ D+
Sbjct: 784 LKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDD 823
Score = 45.4 bits (106), Expect = 1e-04
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 28/345 (8%)
Query: 68 MFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVR 127
MF Q + + N + ++ ++ + N+ L+N+ EME + + A
Sbjct: 319 MFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPE 378
Query: 128 HEFQETKDQLTTE---NIILGGKLAALEE--FRLQKEEVTDKFTLLEEQVRKQENEFRDY 182
E KDQ E N + +A + +KE+ ++ + L Q+ +++E
Sbjct: 379 DEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQ 438
Query: 183 AYNLEK--KSVLDKDRLRKEIIQRVNLVANEFHK--VTTNRMWETTKRAIKENNGITLQM 238
+ EK + +LD+D L + + E + + + K ++ + +
Sbjct: 439 SQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNY 498
Query: 239 ARVSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKR--GHQK-----IILMLT 291
+ SQ+ + NEQL + L ++ L TQ+ +++ + HQK I+ +L
Sbjct: 499 DQKSQEVEDKTRANEQLT---DELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLL 555
Query: 292 KKCQEQQQ--DTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQL---SLQLEQQQVDL 346
K E T + + L + +E+ ++ +KS+ L S QLE Q+D
Sbjct: 556 KDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDS 615
Query: 347 QRL----QQELANEQKVRASLEAALVQATSFLQNILQMHRDEEDS 387
R ++ELA Q + + EA + T ++QN+ Q R E+S
Sbjct: 616 NRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES 660
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 61.6 bits (148), Expect = 2e-09
Identities = 85/336 (25%), Positives = 152/336 (45%), Gaps = 35/336 (10%)
Query: 44 QIRDLEDRLARYQRKWDELAV----------QEKMFRQEFEQLANNKKEIVAFLKRTLNQ 93
+++DLE Q+ +EL + + K QE QL +KK++ KR L Q
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR-LRQ 843
Query: 94 QVDEITDLNEQLQNLQLAK-EMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALE 152
Q EI D + N+++ E E ++ + K+ L EN L K A ++
Sbjct: 844 QA-EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE-LEKENKELV-KRATID 900
Query: 153 EFRLQKEEVTDKFTLLEEQVRKQE--NEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVAN 210
K VT + L+ E+++ Q+ N+ + LEK L+K+RL + +
Sbjct: 901 I----KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLLHD-----EQSTD 950
Query: 211 EFHKVTTNRMWETTKRA--IKENNGITLQMARVSQQGMKLLQENEQLKGRQNNLCKQLEL 268
+ +K+ +++ T K++ IKE L+ AR+ + N+QL+ + K E
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKIAALE-ARLEES----TNYNQQLRQELKTVKKNYEA 1005
Query: 269 LENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQAL 328
L+ Q R + I K +E Q+ T+E +++ L ++E+ + LQ + QAL
Sbjct: 1006 LKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
Query: 329 KSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASLE 364
K+Q QL Q Q + LQ++ + Q+ +L+
Sbjct: 1065 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Score = 58.2 bits (139), Expect = 2e-08
Identities = 83/380 (21%), Positives = 168/380 (44%), Gaps = 41/380 (10%)
Query: 10 AGKELEVKKKGGK-KEPVVAVEPPLAKEMKEFYHIQ--IRDLEDRLARYQRKWDELAV-- 64
A K L+++K+ + + V +E + +E + + Q +DL A+ ++ + L
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549
Query: 65 --QEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQ 122
Q K+ QE E L + + + +V +I N+ L + E +
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609
Query: 123 LAQVRHEFQETKDQ-------------LTTENIILGGKLAALEEFRLQKEEVTDKFTLLE 169
Q++ E + K++ L EN +L K+ L+ + E + + + LE
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 170 EQVRKQE---NEFRDYAYNLE----KKSVLDKDRLR-KEIIQRVNLVANEFHKVTT-NRM 220
+ RK + + F++ + LE + S LD++ L + ++ + + + ++ N+
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 221 WETTKRAIKENNGITLQMA--------RVSQQGMKLLQENEQLKGRQNNLCKQLELLENT 272
E+ K +K+ G+ L A VS QG+ + EN++L+ N K+++ LE+
Sbjct: 730 LESEKEQLKK--GLELLKASFKKTERLEVSYQGLDI--ENQRLQKTLENSNKKIQQLESE 785
Query: 273 QKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQR 332
+ + + QK + L + +Q KE + L SQLE+ QL+ +N+ L+ Q
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 333 DQLSLQLEQQQVDLQRLQQE 352
+ LE+ V + L++E
Sbjct: 846 EIKDTTLEENNVKIGNLEKE 865
Score = 49.7 bits (117), Expect = 7e-06
Identities = 87/397 (21%), Positives = 168/397 (42%), Gaps = 54/397 (13%)
Query: 1 MAPKKSVSKA---GKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQR 57
MA K+S+ ++ G ELE + E A + L E+ E RL + +
Sbjct: 417 MAQKQSMDESLHLGWELEQISR--TSELSEAPQKSLGHEVNEL-------TSSRLLKLEM 467
Query: 58 KWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT--LNQQVD----EITDLNEQLQNLQ-L 110
+ L + R + + N +I+ K L+++V+ EI + LQN Q L
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 111 AKEMEKDAFEAQLAQVRHEFQETKDQ----LTTENIILGGKLAALEE-----FRLQKEEV 161
+K++ K+ +AQL + +E ++ L EN L +++L + + +++
Sbjct: 528 SKDLMKE--KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 162 TDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMW 221
+ +L E +++ ++ + EK+ + + KE +R + NE H +
Sbjct: 586 EKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELENELHHLEKEN-- 641
Query: 222 ETTKRAIKENNGITLQMARVSQQGMKLLQENEQLKGRQN---NLCKQLELLENTQKVMAR 278
E ++ I ++ + Q+ +L +EN +LK + NL QLE LE +
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 279 HK---RGHQKIILMLTKKCQEQQQDTKEAEE--------LRLLLS------QLEQRSLQL 321
R + + + + K + Q + KE E L LL + +LE L
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 322 QVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQK 358
++NQ L+ + + +++Q + +LQ L+ E QK
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Score = 43.9 bits (102), Expect = 4e-04
Identities = 57/264 (21%), Positives = 118/264 (44%), Gaps = 33/264 (12%)
Query: 13 ELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQE 72
EL +++ + E +++ L K ++ RDLEDR + ++ +L EKM + E
Sbjct: 1163 ELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE 1221
Query: 73 FEQ--LANNKKEIVAF-----------LKRTLNQQVDEITDL---NEQLQNLQLAKEMEK 116
E+ L N E VA L T +Q + E L ++ L++L ++E+
Sbjct: 1222 QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQ 1281
Query: 117 DAFEAQLAQVRHEFQE---TKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVR 173
EA+ ++++ ++Q+ T +L + +L LEE + L +
Sbjct: 1282 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1341
Query: 174 KQENEFRDYAYNLEKKSVLDK---DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKE 230
+Q E +D +++E++ +DK R +KE ++ + +F+ + R +
Sbjct: 1342 EQNMESKD-LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPR---------RR 1391
Query: 231 NNGITLQMARVSQQGMKLLQENEQ 254
N ITL+M ++ + + +E ++
Sbjct: 1392 GNWITLKMRKLIKSKKDINRERQK 1415
Score = 42.0 bits (97), Expect = 0.001
Identities = 84/432 (19%), Positives = 174/432 (40%), Gaps = 78/432 (18%)
Query: 29 VEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLK 88
+E L +K+ I+ E+++A + + +E + RQE + + KK A +
Sbjct: 956 LESKLESTLKKSLEIK----EEKIAALEARLEESTNYNQQLRQELKTV---KKNYEALKQ 1008
Query: 89 RTLNQQVDEIT------------DLNEQLQNLQLAKE--MEKDAFEAQLAQVRHEFQETK 134
R +++ + + + E + L K+ +E + A L + +
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1068
Query: 135 DQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVLDK 194
QL T+N L ++ AL+ Q + ++ T L+ Q K + E + N + S++++
Sbjct: 1069 KQLETQNNNLQAQILALQR---QTVSLQEQNTTLQTQNAKLQVE--NSTLNSQSTSLMNQ 1123
Query: 195 DRLRKEIIQRVNLVANEFHKVTTNR--MWETTKRAIKENNGITLQMARVSQQGMKLLQ-- 250
+ +++ + + + NE V R + IK++ + L R + + L+
Sbjct: 1124 NA---QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1180
Query: 251 ------------ENEQLKGRQNNLCKQLELLENTQKV-------MARHKRGHQKIILMLT 291
E+ L+ R N L KQ LE+ +K+ M + H+ +
Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1240
Query: 292 KKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQ 351
K C E + L SQL + + LQ D++ LKS + L+ + + + +L++
Sbjct: 1241 KLCGEN-------DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 352 E----------LANEQKVRASLEAALVQ---------ATSFLQNILQMHRDEEDSDVDVT 392
+ L N+ ++ + L+ L + T LQN + ++ E D+
Sbjct: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Query: 393 FQPWHKEMLQQL 404
Q + + L +L
Sbjct: 1354 EQRQYIDKLNEL 1365
Score = 39.7 bits (91), Expect = 0.007
Identities = 62/344 (18%), Positives = 150/344 (43%), Gaps = 27/344 (7%)
Query: 36 EMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEI------VAFLKR 89
E ++ +++ D + ++ R +++ +E Q +QE EQ+ K + + R
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 90 TLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETK-DQLTTENIILGGKL 148
+ DE+ L E+ + E E ++ +L + EF + + ++L +N +L
Sbjct: 304 SARMYRDELDALREKAVRVDKL-ESEVSRYKERLHDI--EFYKARVEELKEDNQVLLETK 360
Query: 149 AALEEFRLQKEEVTDKFTLLEEQVRKQENEFRDYAY--NLEKKSV--LDKDRLRKEIIQR 204
LE+ +DK LE++ + + + D ++++K + L ++ + E+ Q+
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
Query: 205 VNLVAN-----EFHKVT-TNRMWETTKRAI-KENNGITLQMARVSQQGMKLLQENEQLKG 257
++ + E +++ T+ + E ++++ E N +T S + +KL EN+ L
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT------SSRLLKLEMENQSLTK 474
Query: 258 RQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQR 317
L ++ +E + + ++ +Q++ + E Q+ + + + L L +
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 318 SLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVRA 361
QL+ + L+ ++ LEQ+ L + L ++ A
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Score = 37.4 bits (85), Expect = 0.033
Identities = 66/311 (21%), Positives = 132/311 (42%), Gaps = 50/311 (16%)
Query: 79 NKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDA------FEAQLAQVRHEFQE 132
N E VA + QV + +N +L++ ++ K++ DA + Q++ +QE
Sbjct: 35 NLDEYVALVDGVFLNQV--MLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQE 92
Query: 133 TKDQL---TTENIILGGKLAALEEFRLQKEEVTDKFTLL----EEQVRKQENEFRDYAYN 185
T QL + N+++ GK F Q E K LL Q +K+E EF
Sbjct: 93 TLQQLIMMSLPNVLIIGK----NPFSEQGTEEVKKLLLLLLGCAVQCQKKE-EF------ 141
Query: 186 LEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMA------ 239
+E+ LD D + + + V + V + E T + ++ + MA
Sbjct: 142 IERIQGLDFDT-KAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRL 200
Query: 240 -----RVSQQGMKLLQENEQL------KGRQNNLC-----KQLELLENTQKVMARHKRGH 283
S+ ++L +E + L + C K+ E ++ +A K
Sbjct: 201 IDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKI 260
Query: 284 QKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQ 343
+++ L +K ++ +E E++ + L +L+Q ++ L D ++ + RD+L L ++
Sbjct: 261 RRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD-ALREKA 319
Query: 344 VDLQRLQQELA 354
V + +L+ E++
Sbjct: 320 VRVDKLESEVS 330
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 61.6 bits (148), Expect = 2e-09
Identities = 81/350 (23%), Positives = 148/350 (42%), Gaps = 50/350 (14%)
Query: 35 KEMKEFYHIQI----RDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKKEIVAFLKRT 90
++MKE +H I +LED++ Y+++ DE V K ++ +Q N+ T
Sbjct: 618 EQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE-------THT 670
Query: 91 LNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAA 150
L +Q I+DL ++ LQ + K+A + E ++ + +L E L KL
Sbjct: 671 LEKQ---ISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRL 727
Query: 151 LEEFRL------------QKEEVTDKFTLLEEQVRKQENEFRDY----AYNLEKKSVLDK 194
E L ++ E EE+VR E + +L +K L+K
Sbjct: 728 QHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
Query: 195 DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQENEQ 254
+ LRKE++++ E + E +R + +V+++ LQ
Sbjct: 788 EELRKELLEKHQ---RELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ---S 841
Query: 255 LKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQL 314
L+GR K L+ + +K ++ LT++C E Q+ KE L +
Sbjct: 842 LEGRYRQELKDLQEQQREEKSQWEFEKDE------LTQECAEAQELLKET------LKRE 889
Query: 315 EQRSLQLQVDNQAL-KSQRDQLSLQLEQQQVDLQRLQQELANEQKVRASL 363
+ SL L + + L K+ ++ L+ + ++Q LQ L ++L N + + SL
Sbjct: 890 KTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDL-EDLRNVSETQQSL 938
Score = 45.1 bits (105), Expect = 2e-04
Identities = 99/503 (19%), Positives = 207/503 (41%), Gaps = 118/503 (23%)
Query: 22 KKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWDELAVQEKMFRQEFEQLANNKK 81
+K V E ++M E QI +L+ + + + EL+ + +++ ++L
Sbjct: 1562 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1621
Query: 82 EIVAFLKR-----TLNQQVDEITDLNEQLQNLQLAKEMEKDAFEAQLAQVR---HEFQET 133
E++ ++ L ++ E +L E+L+ ++ + EA+L++V+ H Q+
Sbjct: 1622 EMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQE 1681
Query: 134 ----KDQLTTENII------------LGGKLAALEEFRLQKEEVTD----------KFTL 167
KD+L + + L+ E+ +KE +++ K +L
Sbjct: 1682 NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSL 1741
Query: 168 LEEQVRKQENEFRDYAY---NLEKKSVLDKDRLR--KEIIQRVNLVANEFHKVTTNRMWE 222
LE ++ + E + + + +L+ + V +++++ ++ +Q VNL + + R+ +
Sbjct: 1742 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK--SDLRVTQ 1799
Query: 223 TTKRAIKEN------------------------NGITLQMARVS---------QQGMKLL 249
K A+K+ +G+ Q R+S ++ L
Sbjct: 1800 QEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLW 1859
Query: 250 QENEQLKGRQNNLCKQLELLENTQKVMARHKR---GHQKII-------------LMLTKK 293
QENE+L+ N + EL + +KV HQK + L L ++
Sbjct: 1860 QENERLQTMVQNT--KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRE 1917
Query: 294 CQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQ---------- 343
C + Q++ A ++ LEQ + ++N+ LK ++ +L QL + Q
Sbjct: 1918 CDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSP 1977
Query: 344 ----VDLQRLQQE----LANEQKVRASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQP 395
DLQ LQQ+ + EQ ++ L+ L+QA + I Q ++E ++ T P
Sbjct: 1978 SPHAWDLQLLQQQACPMVPREQFLQ--LQRQLLQA----ERINQHLQEELENRTSETNTP 2031
Query: 396 WHKEMLQQLLVMLSSTVATRPQK 418
+ +QL+ ++ + QK
Sbjct: 2032 QGNQ--EQLVTVMEERMIEVEQK 2052
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/325 (22%), Positives = 151/325 (46%), Gaps = 30/325 (9%)
Query: 89 RTLNQQVDEITDLNEQLQ-NLQLAKEMEKD--AFEAQLAQVRHEFQETKDQ-LTTENIIL 144
R+++ ++E N+ L+ N QL ++++ A+ Q E ++Q + EN L
Sbjct: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
Query: 145 GG-------KLAALEEFRLQKEEVTDKFTLLEEQVR---KQENEFRDYAYNLEKKSVL-D 193
G A + E L+K ++ + L+E+V KQ++ E K+++ D
Sbjct: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
Query: 194 KDRLRKEIIQRVNLVANEFHKVTT-NRMWETTKRAIKENNGIT-LQMARVSQQGMKLLQE 251
E+ Q+V L+ E K+ N + + E + I+ L++ ++ ++ Q+
Sbjct: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1563
Query: 252 NEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLL 311
E +K Q N Q +++EN +K ++ K +Q++ L T+ Q+ Q+ ++ +EL L
Sbjct: 1564 TETVK--QENAAVQ-KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRL 1620
Query: 312 SQLEQRSLQLQVDNQALKSQRDQ---LSLQLEQQQVDLQRLQQELANEQKVRASLEAALV 368
+++ + + + N AL+ + + L +LE+ +V L L E ++ +V
Sbjct: 1621 TEMLCQK-EKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELS-EVKIQTHIV 1678
Query: 369 QATSF-----LQNILQMHRDEEDSD 388
Q + L+ + Q+HR + SD
Sbjct: 1679 QQENHLLKDELEKMKQLHRCPDLSD 1703
Score = 40.8 bits (94), Expect = 0.003
Identities = 73/352 (20%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 38 KEFYHIQIRDLEDRLARYQRKWDELAVQ-EKMFRQEFEQLANNKKEIVAFLKRTLNQQVD 96
KE R+L++ + + + + Q E F+ + +++ + + L+ Q
Sbjct: 792 KELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ--- 848
Query: 97 EITDLNEQLQNLQLAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRL 156
E+ DL EQ + + E EKD + A+ + +ET + T +++L
Sbjct: 849 ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVL------------ 896
Query: 157 QKEEVTDKFTLLEEQVRKQENEFRDYAYNLEKKSVL-DKDRLRKEIIQRVNLVANEFHKV 215
T + +LE+ ++ N + +E++ +L D + LR + +L++++ ++
Sbjct: 897 -----TQEREMLEKTYKEHLN-----SMVVERQQLLQDLEDLRNVSETQQSLLSDQILEL 946
Query: 216 TTNRMWETTKRAIKENNGITLQMARVSQQGMKLLQ--ENEQLKGRQNNLCKQLELLENTQ 273
++ KR ++E + Q Q + L+ E E + RQ + K L +EN
Sbjct: 947 KSSH-----KRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL-AMENIH 1000
Query: 274 KVMA----RHKRGHQKIILMLTKKCQEQQQDTKEAEELRLLLSQLEQRSLQ-------LQ 322
K R + I L K +E QQ T L+ + + ++ LQ
Sbjct: 1001 KATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQ 1060
Query: 323 VDNQALKSQRD-QLSLQLEQQQV--DLQRLQQELANEQKVRASLEAALVQAT 371
Q L+ D LSLQ +Q + ++ E++ Q+ LE LV ++
Sbjct: 1061 QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1112
Score = 30.8 bits (68), Expect = 3.1
Identities = 66/334 (19%), Positives = 140/334 (41%), Gaps = 33/334 (9%)
Query: 71 QEFEQLANNKKEIVAFLKRTLNQQVDE-------ITDLNEQLQNLQLAKEMEK------D 117
Q+ EQL +++ L+R Q V E I+ L ++LQ L+ M
Sbjct: 1060 QQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPAT 1119
Query: 118 AFEAQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQEN 177
F A+ F + E + L+ LE+ +EV D + V++QE
Sbjct: 1120 EFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLED-----DEVRDLGSTGTSSVQRQEV 1174
Query: 178 EFRDYAYNLEKKSVLDK-DRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITL 236
+ + ++E S L+ + R E + N ++ ++ + RA ++ +
Sbjct: 1175 KIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM--LCADCDRASEKKQDLLF 1232
Query: 237 QMARVSQQGMKLLQE----NEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTK 292
++ V ++ +K+L+ + + K ++ ++ + L+ ++M + LT
Sbjct: 1233 DVS-VLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTA 1291
Query: 293 KCQEQQQDTKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQE 352
+ Q + K+ EE+ LE+ +++++N+ L + L L+L+ + LQ +
Sbjct: 1292 EVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEEL----NVLVLRLQGKIEKLQESVVQ 1347
Query: 353 LANEQKVRASLEAALVQATSFLQNILQMHRDEED 386
+ ASLE ++ NILQ+++ E+
Sbjct: 1348 RCDCCLWEASLENLEIEPDG---NILQLNQTLEE 1378
Score = 30.4 bits (67), Expect = 4.1
Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 18/145 (12%)
Query: 248 LLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLT----KKCQEQQQDTKE 303
LL+ +Q+ + L L+ E + +MA H I +K E+ ++
Sbjct: 378 LLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIA 437
Query: 304 A------EELRLLLSQLEQRSLQLQVDNQALKSQ----RDQLSLQLEQQQVDLQRLQQEL 353
A +E +L Q ++ L+L+ + + K++ RD+L+L L++ RL+ EL
Sbjct: 438 ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS----RLENEL 493
Query: 354 ANEQKVRASLEAALVQATSFLQNIL 378
+ A E + L+N+L
Sbjct: 494 LENAEKLAEYENLTNKLQRNLENVL 518
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,494,333
Number of Sequences: 37866
Number of extensions: 868211
Number of successful extensions: 8843
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 816
Number of HSP's that attempted gapping in prelim test: 4608
Number of HSP's gapped (non-prelim): 3088
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.