Guide to the Human Genome
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Search of human proteins with 118600995

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118600995 cripto, FRL-1, cryptic family 1B [Homo sapiens]
         (223 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118600995 cripto, FRL-1, cryptic family 1B [Homo sapiens]          487   e-138
gi|14211837 cryptic [Homo sapiens]                                    482   e-136
gi|4507425 teratocarcinoma-derived growth factor 1 [Homo sapiens]      92   5e-19
gi|169164915 PREDICTED: similar to hCG1644233 [Homo sapiens]           76   3e-14
gi|169163540 PREDICTED: similar to hCG1644233 [Homo sapiens]           76   3e-14
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]             54   1e-07
gi|148833508 notch1 preproprotein [Homo sapiens]                       49   3e-06
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]             48   8e-06
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]               44   1e-04
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]               44   1e-04
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]     44   1e-04
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]               44   1e-04
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]       44   1e-04
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]                43   2e-04
gi|110347437 latent transforming growth factor beta binding prot...    42   3e-04
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             42   5e-04
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]                42   5e-04
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]                42   5e-04
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...    41   7e-04
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]                41   0.001
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]             41   0.001
gi|88702793 slit-like 2 [Homo sapiens]                                 41   0.001
gi|134244285 Notch homolog 3 [Homo sapiens]                            40   0.001
gi|110347412 latent transforming growth factor beta binding prot...    40   0.001
gi|110347431 latent transforming growth factor beta binding prot...    40   0.001
gi|41393583 EGF-like-domain, multiple 7 [Homo sapiens]                 40   0.002
gi|7705889 EGF-like-domain, multiple 7 [Homo sapiens]                  40   0.002
gi|122937283 6720455I24Rik homolog [Homo sapiens]                      40   0.002
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]    40   0.002
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]            40   0.002

>gi|118600995 cripto, FRL-1, cryptic family 1B [Homo sapiens]
          Length = 223

 Score =  487 bits (1254), Expect = e-138
 Identities = 223/223 (100%), Positives = 223/223 (100%)

Query: 1   MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE 60
           MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE
Sbjct: 1   MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE 60

Query: 61  VTGSAEGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR 120
           VTGSAEGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR
Sbjct: 61  VTGSAEGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR 120

Query: 121 SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL 180
           SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL
Sbjct: 121 SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL 180

Query: 181 LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL 223
           LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL
Sbjct: 181 LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL 223


>gi|14211837 cryptic [Homo sapiens]
          Length = 223

 Score =  482 bits (1240), Expect = e-136
 Identities = 222/223 (99%), Positives = 222/223 (99%)

Query: 1   MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE 60
           MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE
Sbjct: 1   MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGE 60

Query: 61  VTGSAEGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR 120
           VTGSAEGWGPEEPLPYS AFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR
Sbjct: 61  VTGSAEGWGPEEPLPYSRAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRR 120

Query: 121 SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL 180
           SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL
Sbjct: 121 SECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLL 180

Query: 181 LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL 223
           LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL
Sbjct: 181 LLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL 223


>gi|4507425 teratocarcinoma-derived growth factor 1 [Homo sapiens]
          Length = 188

 Score = 91.7 bits (226), Expect = 5e-19
 Identities = 36/69 (52%), Positives = 42/69 (60%)

Query: 90  CCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCL 149
           CC NGGTC+LGSFC CP  F GR CEHD R+  CG++ H  W  + C LC+C  G L C 
Sbjct: 82  CCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCF 141

Query: 150 PLQTPDRCD 158
           P      CD
Sbjct: 142 PQAFLPGCD 150


>gi|169164915 PREDICTED: similar to hCG1644233 [Homo sapiens]
          Length = 195

 Score = 75.9 bits (185), Expect = 3e-14
 Identities = 31/69 (44%), Positives = 38/69 (55%)

Query: 90  CCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCL 149
           CC NGGTC+LGSFC C   F G  CEH  R+  CG++ H     + C +C+C  G L C 
Sbjct: 101 CCLNGGTCMLGSFCACLPSFYGWNCEHGVRKENCGSVPHDTRLPKKCSMCKCWHGQLRCF 160

Query: 150 PLQTPDRCD 158
           P      CD
Sbjct: 161 PQAFLPGCD 169


>gi|169163540 PREDICTED: similar to hCG1644233 [Homo sapiens]
          Length = 195

 Score = 75.9 bits (185), Expect = 3e-14
 Identities = 31/69 (44%), Positives = 38/69 (55%)

Query: 90  CCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCL 149
           CC NGGTC+LGSFC C   F G  CEH  R+  CG++ H     + C +C+C  G L C 
Sbjct: 101 CCLNGGTCMLGSFCACLPSFYGWNCEHGVRKENCGSVPHDTRLPKKCSMCKCWHGQLRCF 160

Query: 150 PLQTPDRCD 158
           P      CD
Sbjct: 161 PQAFLPGCD 169


>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
          Length = 763

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 27/59 (45%), Positives = 30/59 (50%), Gaps = 5/59 (8%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC 136
           G G   R  C   CR GGTCV  + CVCP+ FTG +CE D    EC    H  W   AC
Sbjct: 510 GNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKD--IDECALRTHTCWNDSAC 566



 Score = 28.9 bits (63), Expect = 3.7
 Identities = 11/25 (44%), Positives = 15/25 (60%), Gaps = 1/25 (4%)

Query: 131 WTLRACHLCRCIFGALHCLPLQTPD 155
           WT  +C  CRC+ G + C PL  P+
Sbjct: 662 WT-HSCQQCRCLEGEVDCWPLTCPN 685


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 25/54 (46%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 91   CRNGGTCVLG--SF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRC 141
            C NGGTCV G  SF C+CP  FTG YC+HD    +     HG      C   RC
Sbjct: 992  CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRC 1045



 Score = 42.0 bits (97), Expect = 4e-04
 Identities = 22/50 (44%), Positives = 27/50 (54%), Gaps = 10/50 (20%)

Query: 83   GASARPRCCRNGGTCVLGS------FCVCPAHFTGRYCEHDQRRSECGAL 126
            G   +P  C+NGGTC + S       C CPA F G  CE+D R   CG+L
Sbjct: 1310 GCKGKP--CKNGGTCAVASNTARGFICKCPAGFEGATCENDAR--TCGSL 1355



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 27/77 (35%), Positives = 33/77 (42%), Gaps = 10/77 (12%)

Query: 87  RPRCCRNGGTCVLG---SFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC---HLCR 140
           RP  C NGG+C  G   +FC C   F G +CE D          +GA     C   + C 
Sbjct: 912 RPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGA-NCTDCVDSYTCT 970

Query: 141 CI--FGALHCLPLQTPD 155
           C   F  +HC    TPD
Sbjct: 971 CPAGFSGIHC-ENNTPD 986



 Score = 38.5 bits (88), Expect = 0.005
 Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 11/63 (17%)

Query: 91  CRNGGTCVLGSF---CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH------LCRC 141
           C+NGG CV G     C CP  +TG+YC  D    EC  + +       CH       C C
Sbjct: 266 CKNGGACVDGVNTYNCRCPPEWTGQYCTEDV--DECQLMPNACQNGGTCHNTHGGYNCVC 323

Query: 142 IFG 144
           + G
Sbjct: 324 VNG 326



 Score = 37.7 bits (86), Expect = 0.008
 Identities = 26/64 (40%), Positives = 29/64 (45%), Gaps = 7/64 (10%)

Query: 74  LPYSWAFGEG--ASARPRCCRNGGTCVLG----SF-CVCPAHFTGRYCEHDQRRSECGAL 126
           LPY+ A  E   A   P  CRNGG C       SF CVCP  + G+ CE D         
Sbjct: 819 LPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPC 878

Query: 127 EHGA 130
            HGA
Sbjct: 879 RHGA 882



 Score = 37.7 bits (86), Expect = 0.008
 Identities = 25/84 (29%), Positives = 29/84 (34%), Gaps = 15/84 (17%)

Query: 91   CRNGGTCVLGSF---CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC----------- 136
            C+NGG C        C CP+ +TG YC+      E  A   G    R C           
Sbjct: 1068 CKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGN 1127

Query: 137  -HLCRCIFGALHCLPLQTPDRCDP 159
             H CRC  G          D C P
Sbjct: 1128 THHCRCQAGYTGSYCEDLVDECSP 1151



 Score = 35.4 bits (80), Expect = 0.039
 Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 87  RPRCCRNGGTC--VLGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAW---TLRACHLCR 140
           +P  CR+GGTC   +GS+ CVC A  TG  CE           ++G     T    H C 
Sbjct: 185 KPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECA 244

Query: 141 CIFG 144
           C+ G
Sbjct: 245 CLPG 248



 Score = 34.3 bits (77), Expect = 0.088
 Identities = 23/66 (34%), Positives = 26/66 (39%), Gaps = 13/66 (19%)

Query: 88  PRCCRNGGTCVL---GSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH------L 138
           P  C+NGGTC     G  CVC   +TG  C  +       A  HGA     CH       
Sbjct: 303 PNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGA----TCHDRVASFY 358

Query: 139 CRCIFG 144
           C C  G
Sbjct: 359 CECPHG 364



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 22/76 (28%), Positives = 32/76 (42%), Gaps = 9/76 (11%)

Query: 91  CRNGGTCV--LGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCI----F 143
           C + G C+  +  F C CP  FTG  C++D         ++GA  L   +   C+    +
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY 558

Query: 144 GALHCLPLQTPDRCDP 159
              HC      D CDP
Sbjct: 559 TGTHC--EVDIDECDP 572



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 7/65 (10%)

Query: 91   CRNGGTCV--LGSF-CVCPAHFTGRYCEHDQRRSECGALEHG--AWTLRACHLCRCIFG- 144
            C +GGTC    GS+ C CP  +TG  C++     +    ++G   W     + C C  G 
Sbjct: 1030 CLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGW 1089

Query: 145  -ALHC 148
              L+C
Sbjct: 1090 TGLYC 1094



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 91  CRNGGTCVLGSF----CVCPAHFTGRYCEH-DQRRSECGALEHGAWTLRACHLCRC 141
           CRNGGTC L +     C CP  ++G+ C+  D   S   A         A ++C C
Sbjct: 111 CRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHC 166



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 91   CRNGGTCV--LGSF-CVCPAHFTGRYCEHD 117
            C N GTCV  +G + C CP  F G  CE D
Sbjct: 1238 CFNNGTCVDQVGGYSCTCPPGFVGERCEGD 1267



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 13/28 (46%), Positives = 16/28 (57%), Gaps = 3/28 (10%)

Query: 91   CRNGGTCVLG---SFCVCPAHFTGRYCE 115
            C NGGTC+ G     C+C   FTG  C+
Sbjct: 1357 CLNGGTCISGPRSPTCLCLGPFTGPECQ 1384



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 12/75 (16%)

Query: 91  CRNGGTCVLG-----SFCVCPAHFTGRYCEHDQRRSECGA--LEHGAWTLRACHLCRCIF 143
           C  G  C        + C CP+ +TG  C  D      GA   EH    +       C  
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFEC-- 438

Query: 144 GALHCLPLQTPDRCD 158
               CL   T  RC+
Sbjct: 439 ---QCLQGYTGPRCE 450



 Score = 29.6 bits (65), Expect = 2.2
 Identities = 14/34 (41%), Positives = 18/34 (52%), Gaps = 4/34 (11%)

Query: 88  PRCCRNGGTCV----LGSFCVCPAHFTGRYCEHD 117
           P  C+NGGTC     +   C C   FTG+ CE +
Sbjct: 224 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEEN 257



 Score = 28.1 bits (61), Expect = 6.3
 Identities = 14/43 (32%), Positives = 17/43 (39%), Gaps = 3/43 (6%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGA 130
           C NGGTC   + G  C CP  +    C  +          HGA
Sbjct: 687 CHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA 729



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 91  CRNGGTCVL---GSFCVCPAHFTGRYCEHD 117
           CR+G +C     G  C C A ++GR CE D
Sbjct: 878 CRHGASCQNTHGGYRCHCQAGYSGRNCETD 907


>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
          Length = 810

 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 29/74 (39%), Positives = 34/74 (45%), Gaps = 14/74 (18%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH 137
           G G   R  C   CR GGTCV  + CVCP+ FTG +CE D      G +E        CH
Sbjct: 510 GNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIE--------CH 561

Query: 138 ---LCRCIFGALHC 148
               C  + G  HC
Sbjct: 562 NHSRCVNLPGWYHC 575



 Score = 28.9 bits (63), Expect = 3.7
 Identities = 11/25 (44%), Positives = 15/25 (60%), Gaps = 1/25 (4%)

Query: 131 WTLRACHLCRCIFGALHCLPLQTPD 155
           WT  +C  CRC+ G + C PL  P+
Sbjct: 709 WT-HSCQQCRCLEGEVDCWPLTCPN 732


>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
          Length = 839

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 3/40 (7%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHD 117
           G G + +  C   CRNGG C+  + C CP  FTG  CE D
Sbjct: 539 GNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 578



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 11/75 (14%)

Query: 91  CRNGGTCVLGSFCVCPAHFTGRYC--EHDQRRSECGALEHG--------AWTLRACHLCR 140
           C+NG        C C       +C  E D R S     ++G         W ++ C  CR
Sbjct: 688 CQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW-VQNCQQCR 746

Query: 141 CIFGALHCLPLQTPD 155
           C+ G + C PL  PD
Sbjct: 747 CLQGEVDCWPLPCPD 761


>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
          Length = 815

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 3/40 (7%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHD 117
           G G + +  C   CRNGG C+  + C CP  FTG  CE D
Sbjct: 515 GNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 554



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 11/75 (14%)

Query: 91  CRNGGTCVLGSFCVCPAHFTGRYC--EHDQRRSECGALEHG--------AWTLRACHLCR 140
           C+NG        C C       +C  E D R S     ++G         W ++ C  CR
Sbjct: 664 CQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW-VQNCQQCR 722

Query: 141 CIFGALHCLPLQTPD 155
           C+ G + C PL  PD
Sbjct: 723 CLQGEVDCWPLPCPD 737


>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 3/40 (7%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHD 117
           G G + +  C   CRNGG C+  + C CP  FTG  CE D
Sbjct: 516 GNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 555



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 11/75 (14%)

Query: 91  CRNGGTCVLGSFCVCPAHFTGRYC--EHDQRRSECGALEHG--------AWTLRACHLCR 140
           C+NG        C C       +C  E D R S     ++G         W ++ C  CR
Sbjct: 665 CQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW-VQNCQQCR 723

Query: 141 CIFGALHCLPLQTPD 155
           C+ G + C PL  PD
Sbjct: 724 CLQGEVDCWPLPCPD 738


>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
          Length = 866

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 3/40 (7%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHD 117
           G G + +  C   CRNGG C+  + C CP  FTG  CE D
Sbjct: 566 GNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 605



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 11/75 (14%)

Query: 91  CRNGGTCVLGSFCVCPAHFTGRYC--EHDQRRSECGALEHG--------AWTLRACHLCR 140
           C+NG        C C       +C  E D R S     ++G         W ++ C  CR
Sbjct: 715 CQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW-VQNCQQCR 773

Query: 141 CIFGALHCLPLQTPD 155
           C+ G + C PL  PD
Sbjct: 774 CLQGEVDCWPLPCPD 788


>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 3/40 (7%)

Query: 81  GEGASARPRC---CRNGGTCVLGSFCVCPAHFTGRYCEHD 117
           G G + +  C   CRNGG C+  + C CP  FTG  CE D
Sbjct: 516 GNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 555



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 11/75 (14%)

Query: 91  CRNGGTCVLGSFCVCPAHFTGRYC--EHDQRRSECGALEHG--------AWTLRACHLCR 140
           C+NG        C C       +C  E D R S     ++G         W ++ C  CR
Sbjct: 665 CQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW-VQNCQQCR 723

Query: 141 CIFGALHCLPLQTPD 155
           C+ G + C PL  PD
Sbjct: 724 CLQGEVDCWPLPCPD 738


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 28/92 (30%), Positives = 38/92 (41%), Gaps = 4/92 (4%)

Query: 79  AFGEGASARPRCCRNGGTCVLG-SFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH 137
           +FG   S     CRNGGTC+LG   C CP  +TG  C         G     + + +   
Sbjct: 515 SFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGG 574

Query: 138 LCRCIFGALHCLPLQTPDRCD---PKDFLASH 166
            C  + GA  C P  +   C+   PK +   H
Sbjct: 575 TCDSVTGACRCPPGVSGTNCEDGCPKGYYGKH 606



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 4/55 (7%)

Query: 91  CRNGGTCVLGSF--CVCPAHFTGRYCEH--DQRRSECGALEHGAWTLRACHLCRC 141
           C +GG CV GS   C CP  F G  C++  D+ R+  G  +H        +LC C
Sbjct: 133 CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCEC 187



 Score = 37.4 bits (85), Expect = 0.010
 Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 12/71 (16%)

Query: 91   CRNGGTC-VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHL-CRCIFGALHC 148
            CRNGG C      C C   +TGR+CE       C    +GA    ACHL C C   +  C
Sbjct: 1307 CRNGGLCHASNGSCSCGLGWTGRHCE-----LACPPGRYGA----ACHLECSCHNNST-C 1356

Query: 149  LPLQTPDRCDP 159
             P     RC P
Sbjct: 1357 EPATGTCRCGP 1367



 Score = 36.2 bits (82), Expect = 0.023
 Identities = 32/96 (33%), Positives = 41/96 (42%), Gaps = 16/96 (16%)

Query: 67   GWGPEEPLPYSWAFGEGASARPRC-CRNGGTC-VLGSFCVCPAHFTGRYCEHDQRRSECG 124
            G   E P P  +    GA  +  C C++G  C  +   C+CPA F G +CE   R  E G
Sbjct: 1371 GQACEHPCPPGF---HGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCE---RGCEPG 1424

Query: 125  ALEHGAWTLRACH-LCRCIFGALHCLPLQTPDRCDP 159
            +   G      CH  C C  GA  C P+     C P
Sbjct: 1425 SFGEG------CHQRCDCDGGA-PCDPVTGLCLCPP 1453



 Score = 35.8 bits (81), Expect = 0.030
 Identities = 26/109 (23%), Positives = 39/109 (35%), Gaps = 2/109 (1%)

Query: 80   FGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLC 139
            FG G   R +C        +   C CPA + G +CEH       G     A    A   C
Sbjct: 909  FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC 968

Query: 140  RCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLLLLPCALLH 188
              + G+  C   +   RC   +   +H +G +   A +      C  +H
Sbjct: 969  DAVNGSCLCPAGRRGPRC--AETCPAHTYGHNCSQACACFNGASCDPVH 1015



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 30/96 (31%), Positives = 36/96 (37%), Gaps = 4/96 (4%)

Query: 65   AEGWGPEEPLPYSWAFGEGASARPRC-CRNGGTC-VLGSFCVCPAHFTGRYCEHD-QRRS 121
            A GW     L    A   G + R  C C+NGGTC  +   C CP  + G  CE +   R 
Sbjct: 1021 APGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRD 1080

Query: 122  ECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRC 157
                  H    L    LC    G   C    T D+C
Sbjct: 1081 VRAGCRHSGGCLNG-GLCDPHTGRCLCPAGWTGDKC 1115



 Score = 32.7 bits (73), Expect = 0.26
 Identities = 26/99 (26%), Positives = 35/99 (35%), Gaps = 18/99 (18%)

Query: 75   PYSWAFGEGASARPRC--------CRNGGTCVLGSFC-------VCPAHFTGRYCEHDQR 119
            P  WA   G +    C        CR+ G C+ G  C       +CPA +TG  C+    
Sbjct: 1064 PEGWA---GLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCL 1120

Query: 120  RSECGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRCD 158
            R   G       +      C  + GA  C P  T   C+
Sbjct: 1121 RGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCE 1159



 Score = 30.8 bits (68), Expect = 0.97
 Identities = 33/100 (33%), Positives = 37/100 (37%), Gaps = 22/100 (22%)

Query: 83  GASARPRCCRNGGTC--VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTL------R 134
           G +    C   G  C  V G  C CP   TG  CE D           G W L       
Sbjct: 737 GVNCSSSCSCGGAPCHGVTGQ-CRCPPGRTGEDCEAD--------CPEGRWGLGCQEICP 787

Query: 135 AC-HLCRC--IFGALHCLPLQTPDRCDPKDFLASHAHGPS 171
           AC H  RC    GA  CLP     RC  +D   +  +GPS
Sbjct: 788 ACQHAARCDPETGACLCLPGFVGSRC--QDVCPAGWYGPS 825



 Score = 30.8 bits (68), Expect = 0.97
 Identities = 23/80 (28%), Positives = 30/80 (37%), Gaps = 13/80 (16%)

Query: 71  EEPLPYSWAFGEGASARPRC-CRNGGTCVLGS-FCVCPAHFTGRYCEHDQRRSECGALEH 128
           ++  P  W    G S + RC C N G C   +  C C   +TG  C+         A + 
Sbjct: 814 QDVCPAGWY---GPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQR--------ACDT 862

Query: 129 GAWTLRACHLCRCIFGALHC 148
           G W     H C C  G   C
Sbjct: 863 GHWGPDCSHPCNCSAGHGSC 882



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 20/61 (32%), Positives = 24/61 (39%), Gaps = 5/61 (8%)

Query: 78  WAFGEGASARPRCCR-NGGTC-VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRA 135
           WAFG G S   +C + +  +C      C C A F G  C   Q   E G    G W    
Sbjct: 644 WAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERC---QAECELGYFGPGCWQACT 700

Query: 136 C 136
           C
Sbjct: 701 C 701



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 33/97 (34%), Positives = 37/97 (38%), Gaps = 17/97 (17%)

Query: 83   GASARPRC-CRNGGTCVLGS-FCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH-LC 139
            GA+    C C N  TC   +  C C   F G+ CEH      C    HGA     C  LC
Sbjct: 1341 GAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEH-----PCPPGFHGA----GCQGLC 1391

Query: 140  RCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAP 176
             C  GA  C P+     C P  F   H H    G  P
Sbjct: 1392 WCQHGA-PCDPISGRCLC-PAGF---HGHFCERGCEP 1423



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 11/80 (13%)

Query: 79   AFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHL 138
            +FGEG   R  C        +   C+CP   +G  C  D RR + G          +C L
Sbjct: 1425 SFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGP---------SCTL 1475

Query: 139  -CRCIFGALHCLPLQTPDRC 157
             C C  GA  C P+     C
Sbjct: 1476 HCDCGGGA-DCDPVSGQCHC 1494



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 21/70 (30%), Positives = 26/70 (37%), Gaps = 10/70 (14%)

Query: 91   CRNGGTCVLGS-FCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCL 149
            C NGG+C   +  C CP  F G  C              G +     H+C C  GA  C 
Sbjct: 1221 CLNGGSCDAATGACRCPTGFLGTDCNL--------TCPQGRFGPNCTHVCGCGQGAA-CD 1271

Query: 150  PLQTPDRCDP 159
            P+     C P
Sbjct: 1272 PVTGTCLCPP 1281



 Score = 28.1 bits (61), Expect = 6.3
 Identities = 19/76 (25%), Positives = 28/76 (36%), Gaps = 14/76 (18%)

Query: 80  FGEGASARPRCCRNGGTC-VLGSFCVCPAHFTGRYCEHD----------QRRSECGALEH 128
           +G   S    C    G+C  +   C+C A + G  CE            ++R +C   +H
Sbjct: 865 WGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQC---QH 921

Query: 129 GAWTLRACHLCRCIFG 144
           GA        C C  G
Sbjct: 922 GAACDHVSGACTCPAG 937


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 11/67 (16%)

Query: 49  SPLNWTSSHFGEVTGSAEGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAH 108
           +P N TS   G   G+A G GP          G  A   P  C NGG CV    C+CP  
Sbjct: 59  APRNATSVDSGAPGGAAPG-GP----------GFRAFLCPLICHNGGVCVKPDRCLCPPD 107

Query: 109 FTGRYCE 115
           F G++C+
Sbjct: 108 FAGKFCQ 114



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 10/45 (22%)

Query: 83  GASARP--RCCRNGGTC-------VLGSF-CVCPAHFTGRYCEHD 117
           GAS +    C ++ G C       + GSF CVCPA F G  CE D
Sbjct: 599 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 643


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 40/127 (31%), Positives = 49/127 (38%), Gaps = 26/127 (20%)

Query: 85   SARPRCCRNGGTC----VLGSFCVCPAHFTGRYCEHDQ----RRSECGALEHGAWTLR-- 134
            + R R C+NGG C         CVCPA FTG  CEH Q        CG     A  +   
Sbjct: 3847 TCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGP---DATCVNRP 3903

Query: 135  --ACHLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLLLLPCALLHRLLR 192
                + CRC  G       ++  RC+    + +    PS  GA S L L      H  LR
Sbjct: 3904 DGRGYTCRCHLG-------RSGLRCEEGVTVTT----PSLSGAGSYLALPALTNTHHELR 3952

Query: 193  PDAPAHP 199
             D    P
Sbjct: 3953 LDVEFKP 3959



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 36/124 (29%), Positives = 49/124 (39%), Gaps = 27/124 (21%)

Query: 49   SPLNWTSSHFGEVTGSAEGWGPEEPLPYSWAFGEG-------ASARPRCCRNGGTCV-LG 100
            SP    S+HF    G     G    L YS+   +G       +    + C++G TC+  G
Sbjct: 4064 SPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAG 4123

Query: 101  SF---CVCPAHFTGRYCEHD----QRRSECGALEHGAWTLRACHLCRCIFGALHCLPLQT 153
             +   C+C   F G  CEH+    Q R  C    HG      C   RC+     CLP  +
Sbjct: 4124 EYEFQCLCRDGFKGDLCEHEENPCQLREPC---LHGG----TCQGTRCL-----CLPGFS 4171

Query: 154  PDRC 157
              RC
Sbjct: 4172 GPRC 4175


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 25/64 (39%), Positives = 31/64 (48%), Gaps = 16/64 (25%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH---LCRCIFG 144
           C++GGTC   V G  CVCP  F GR+CE +  R EC +          CH   LC  +  
Sbjct: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELE--RDECAS--------SPCHSGGLCEDLAD 480

Query: 145 ALHC 148
             HC
Sbjct: 481 GFHC 484



 Score = 34.3 bits (77), Expect = 0.088
 Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 7/65 (10%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGA--WTLRACHLCRC--IF 143
           C +GG C     G  C CP  F+G  CE D    E     +GA  + L   + C C   F
Sbjct: 469 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 528

Query: 144 GALHC 148
           G  +C
Sbjct: 529 GGKNC 533



 Score = 33.9 bits (76), Expect = 0.11
 Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 5/51 (9%)

Query: 79  AFGEGASARPRCCRNGGTCV---LGSFCVCPAHFTGRYCEHDQRRSECGAL 126
           A  + +S  P  C NGGTCV       C+C   + GR C H+   ++C  L
Sbjct: 710 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN--TNDCNPL 758



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 8/51 (15%)

Query: 91  CRNGGTCVLGS----FCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH 137
           C NGGTC+        C CP  ++GR CE  +         +G     +CH
Sbjct: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG----SCH 363



 Score = 31.6 bits (70), Expect = 0.57
 Identities = 13/28 (46%), Positives = 19/28 (67%), Gaps = 3/28 (10%)

Query: 91  CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
           CRNGGTC+  + +F C CP+ + G  C+
Sbjct: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCD 634



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 20/66 (30%), Positives = 25/66 (37%), Gaps = 8/66 (12%)

Query: 91  CRNGGTCV---LGSFCVCPAHFTGRYCEH-----DQRRSECGALEHGAWTLRACHLCRCI 142
           C  G TCV    G  C CP    G  C+          S      HG+  +  C+ CRC+
Sbjct: 798 CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 857

Query: 143 FGALHC 148
            G   C
Sbjct: 858 DGRRDC 863



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 4/41 (9%)

Query: 81  GEGASARPRCCRNGGTCVL---GSF-CVCPAHFTGRYCEHD 117
           G   +A    C   G CV    G+F C+C + FTG YC  +
Sbjct: 558 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 25/64 (39%), Positives = 31/64 (48%), Gaps = 16/64 (25%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH---LCRCIFG 144
           C++GGTC   V G  CVCP  F GR+CE +  R EC +          CH   LC  +  
Sbjct: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELE--RDECAS--------SPCHSGGLCEDLAD 518

Query: 145 ALHC 148
             HC
Sbjct: 519 GFHC 522



 Score = 34.3 bits (77), Expect = 0.088
 Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 7/65 (10%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGA--WTLRACHLCRC--IF 143
           C +GG C     G  C CP  F+G  CE D    E     +GA  + L   + C C   F
Sbjct: 507 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566

Query: 144 GALHC 148
           G  +C
Sbjct: 567 GGKNC 571



 Score = 33.9 bits (76), Expect = 0.11
 Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 5/51 (9%)

Query: 79  AFGEGASARPRCCRNGGTCV---LGSFCVCPAHFTGRYCEHDQRRSECGAL 126
           A  + +S  P  C NGGTCV       C+C   + GR C H+   ++C  L
Sbjct: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN--TNDCNPL 796



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 8/51 (15%)

Query: 91  CRNGGTCVLGS----FCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH 137
           C NGGTC+        C CP  ++GR CE  +         +G     +CH
Sbjct: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG----SCH 363



 Score = 31.6 bits (70), Expect = 0.57
 Identities = 13/28 (46%), Positives = 19/28 (67%), Gaps = 3/28 (10%)

Query: 91  CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
           CRNGGTC+  + +F C CP+ + G  C+
Sbjct: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCD 672



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 20/66 (30%), Positives = 25/66 (37%), Gaps = 8/66 (12%)

Query: 91  CRNGGTCV---LGSFCVCPAHFTGRYCEH-----DQRRSECGALEHGAWTLRACHLCRCI 142
           C  G TCV    G  C CP    G  C+          S      HG+  +  C+ CRC+
Sbjct: 836 CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895

Query: 143 FGALHC 148
            G   C
Sbjct: 896 DGRRDC 901



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 4/41 (9%)

Query: 81  GEGASARPRCCRNGGTCVL---GSF-CVCPAHFTGRYCEHD 117
           G   +A    C   G CV    G+F C+C + FTG YC  +
Sbjct: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 636


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
           domains 1 [Homo sapiens]
          Length = 1138

 Score = 41.2 bits (95), Expect = 7e-04
 Identities = 19/38 (50%), Positives = 24/38 (63%), Gaps = 1/38 (2%)

Query: 83  GASARPRC-CRNGGTCVLGSFCVCPAHFTGRYCEHDQR 119
           GA  R +C C+NGGTC   S CVCP+ + G +CE   R
Sbjct: 312 GADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDR 349



 Score = 31.2 bits (69), Expect = 0.74
 Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 1/46 (2%)

Query: 80  FGEGASARPRCCRNGGTCV-LGSFCVCPAHFTGRYCEHDQRRSECG 124
           +G G +     C +GG C      CVCP  FTG  CE   R    G
Sbjct: 220 WGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFG 265


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 8/35 (22%)

Query: 91   CRNGGTC--------VLGSFCVCPAHFTGRYCEHD 117
            C NGGTC        ++   C CP HFTGR+CE D
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 12/28 (42%), Positives = 18/28 (64%), Gaps = 3/28 (10%)

Query: 91   CRNGGTCVLGS---FCVCPAHFTGRYCE 115
            CRN GTC+  +   FC CP  ++G+ C+
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ 2371



 Score = 32.7 bits (73), Expect = 0.26
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 7/43 (16%)

Query: 91  CRNGGTC----VLGSF-CVCPAHFTGRYCEHDQRRSECGALEH 128
           C NGG C    + G F C+CP  +TG++C   QR + C  L +
Sbjct: 818 CMNGGLCHESTIPGQFVCLCPPLYTGQFCH--QRYNLCDLLHN 858



 Score = 31.2 bits (69), Expect = 0.74
 Identities = 13/28 (46%), Positives = 15/28 (53%), Gaps = 3/28 (10%)

Query: 91   CRNGGTC---VLGSFCVCPAHFTGRYCE 115
            C N G C     G  C+CP  +TG YCE
Sbjct: 1088 CMNEGFCQKSAHGFTCICPRGYTGAYCE 1115



 Score = 31.2 bits (69), Expect = 0.74
 Identities = 14/31 (45%), Positives = 15/31 (48%), Gaps = 3/31 (9%)

Query: 88   PRCCRNGGTCVL---GSFCVCPAHFTGRYCE 115
            P  C  G TC+    G  C CP   TG YCE
Sbjct: 2659 PHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 21/71 (29%), Positives = 28/71 (39%), Gaps = 24/71 (33%)

Query: 91   CRNGGTCV---LGSFCVCPAHFTGRYC---------EHD-----QRRSECGALEHGAWTL 133
            C NGGTC+      +C C   + G +C         EHD      R + C +L HG    
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHG---- 2674

Query: 134  RACHLCRCIFG 144
               + C C  G
Sbjct: 2675 ---YTCFCPLG 2682



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 16/44 (36%), Positives = 20/44 (45%), Gaps = 4/44 (9%)

Query: 91   CRNGGTCVLGSF----CVCPAHFTGRYCEHDQRRSECGALEHGA 130
            C NGG CV G      C C   F+G++CE +          HGA
Sbjct: 1131 CLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGA 1174



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 12/31 (38%), Positives = 15/31 (48%), Gaps = 4/31 (12%)

Query: 91  CRNGGTCVL----GSFCVCPAHFTGRYCEHD 117
           CRN  TC+        C+C   F G+ CE D
Sbjct: 860 CRNNSTCLALVDANQHCICREEFEGKNCEID 890



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 91  CRNGGTCVLGS---FCVCPAHFTGRYCEHD 117
           C+N GTCV  +   FC C   + G +CE D
Sbjct: 937 CKNNGTCVDLTNRFFCNCEPEYHGPFCELD 966



 Score = 28.9 bits (63), Expect = 3.7
 Identities = 22/70 (31%), Positives = 27/70 (38%), Gaps = 8/70 (11%)

Query: 53   WTSSHFGEVTGSA----EGWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGS----FCV 104
            W + H     G+     E    E P  YS    + AS     C NG TCV  S     C+
Sbjct: 2338 WCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCL 2397

Query: 105  CPAHFTGRYC 114
            CP   +G  C
Sbjct: 2398 CPYGRSGPLC 2407



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 21/72 (29%), Positives = 27/72 (37%), Gaps = 21/72 (29%)

Query: 91  CRNGGTC-----------------VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTL 133
           C+NG TC                 V G  C+C   + G  CE D       A EH + T 
Sbjct: 690 CKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNS-TC 748

Query: 134 RACHL---CRCI 142
           +  HL   C C+
Sbjct: 749 KDLHLSYQCVCL 760


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)

Query: 77   SWAFGEGASARPRCCRNGGTC--VLGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTL 133
            SW   +     P  C +GGTC  ++G F C CP  FTGR CE D         ++GA   
Sbjct: 3857 SWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGA--- 3913

Query: 134  RACHLCRCIFGALHCL 149
                +C+   G+ +C+
Sbjct: 3914 ----ICQNFPGSFNCV 3925



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 23/65 (35%), Positives = 28/65 (43%), Gaps = 7/65 (10%)

Query: 91   CRNGGTC--VLGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRA--CHLCRCIFGA 145
            C+NG  C    GSF CVC   +TG+ CE      EC    +G         + C C FG 
Sbjct: 3909 CKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGV 3968

Query: 146  L--HC 148
               HC
Sbjct: 3969 FGKHC 3973



 Score = 30.8 bits (68), Expect = 0.97
 Identities = 14/29 (48%), Positives = 16/29 (55%), Gaps = 4/29 (13%)

Query: 91   CRNGGTCVLGSF----CVCPAHFTGRYCE 115
            C+NGG+C  G      C CP   TGR CE
Sbjct: 4435 CQNGGSCEPGLHSGFTCSCPDSHTGRTCE 4463



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 4/37 (10%)

Query: 82   EGASARPRCCRNGGTCV---LGSFCVCPAHFTGRYCE 115
            EGA  R  C ++GGTC+       C C    TG+YCE
Sbjct: 4163 EGACTRSPC-QHGGTCMDYWSWQQCHCKEGLTGKYCE 4198



 Score = 28.5 bits (62), Expect = 4.8
 Identities = 12/28 (42%), Positives = 16/28 (57%), Gaps = 3/28 (10%)

Query: 91   CRNGGTCVLGS---FCVCPAHFTGRYCE 115
            C NGG+C  G    +C CP    G++CE
Sbjct: 3947 CFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 18/32 (56%), Positives = 20/32 (62%), Gaps = 4/32 (12%)

Query: 88  PRCCRNGGTCVLGS----FCVCPAHFTGRYCE 115
           P  C NGGTC LG+     C+CP  FTG YCE
Sbjct: 411 PSTCLNGGTCHLGTRHHLACLCPEGFTGLYCE 442


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 40.4 bits (93), Expect = 0.001
 Identities = 35/106 (33%), Positives = 40/106 (37%), Gaps = 15/106 (14%)

Query: 81   GEGASARPRCCRNGGTCV--LGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC- 136
            G    + PRC  NG TCV  +G F C CP  +TG  CE D      GA  H A T R C 
Sbjct: 1167 GPPLDSGPRCLHNG-TCVDLVGGFRCTCPPGYTGLRCEADINECRSGAC-HAAHT-RDCL 1223

Query: 137  --------HLCRCIFGALHCLPLQTPDRCDPKDFLASHAHGPSAGG 174
                     LC   F    C  + +P    P          P  GG
Sbjct: 1224 QDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGG 1269



 Score = 37.4 bits (85), Expect = 0.010
 Identities = 30/89 (33%), Positives = 35/89 (39%), Gaps = 15/89 (16%)

Query: 91   CRNGGTCV---LGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGA-- 145
            C+ GG CV      +CVCP   TG +CE +         +HG         CR   G   
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGG-------TCRGYMGGYM 1107

Query: 146  LHCLPLQTPDRC-DPKDFLASH--AHGPS 171
              CLP    D C D  D  AS    HG S
Sbjct: 1108 CECLPGYNGDNCEDDVDECASQPCQHGGS 1136



 Score = 37.0 bits (84), Expect = 0.014
 Identities = 17/33 (51%), Positives = 22/33 (66%), Gaps = 3/33 (9%)

Query: 88  PRCCRNGGTCVLG--SF-CVCPAHFTGRYCEHD 117
           P  C NGGTCV G  SF C+C   +TG +C+H+
Sbjct: 930 PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 11/63 (17%)

Query: 91  CRNGGTCVLGSF---CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC------HLCRC 141
           C NGGTCV G     C CP  +TG++C  D    EC    +       C      H C C
Sbjct: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV--DECQLQPNACHNGGTCFNTLGGHSCVC 302

Query: 142 IFG 144
           + G
Sbjct: 303 VNG 305



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 17/30 (56%), Positives = 20/30 (66%), Gaps = 3/30 (10%)

Query: 91  CRNGGTCV--LGSF-CVCPAHFTGRYCEHD 117
           CRN  TC+  +G F C+C A FTG YCE D
Sbjct: 440 CRNQATCLDRIGQFTCICMAGFTGTYCEVD 469



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 13/26 (50%), Positives = 20/26 (76%), Gaps = 1/26 (3%)

Query: 91   CRNGGTCV-LGSFCVCPAHFTGRYCE 115
            C+NGG CV  G++C+CP  ++GR C+
Sbjct: 1009 CQNGGRCVQTGAYCLCPPGWSGRLCD 1034



 Score = 35.8 bits (81), Expect = 0.030
 Identities = 17/29 (58%), Positives = 21/29 (72%), Gaps = 3/29 (10%)

Query: 91  CRNGGTCVL--GSF-CVCPAHFTGRYCEH 116
           CR+GGTC+   GSF C CPA +TG  CE+
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCEN 196



 Score = 35.4 bits (80), Expect = 0.039
 Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 5/74 (6%)

Query: 91  CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRA--CHLCRCIFGA 145
           C NGG C   V G  C CP+ F+G  C+ D          +GA  +     + CRC  G 
Sbjct: 478 CVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGF 537

Query: 146 LHCLPLQTPDRCDP 159
              L  +  D C P
Sbjct: 538 EGTLCDRNVDDCSP 551



 Score = 35.0 bits (79), Expect = 0.051
 Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 13/67 (19%)

Query: 87  RPRCCRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACH------ 137
           +P  C NGGTC   + G  CVC   +TG  C  +          HGA     CH      
Sbjct: 281 QPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGA----TCHDRVASF 336

Query: 138 LCRCIFG 144
            C C  G
Sbjct: 337 YCACPMG 343



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 17/37 (45%), Positives = 18/37 (48%), Gaps = 7/37 (18%)

Query: 86  ARPRC----CRNGGTCV---LGSFCVCPAHFTGRYCE 115
           AR  C    CR GGTC    +G  C CP    GR CE
Sbjct: 734 ARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE 770



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 20/66 (30%), Positives = 24/66 (36%), Gaps = 5/66 (7%)

Query: 91  CRNGGTCVLGS----FCVCPAHFTGRYCEHDQRRSECG-ALEHGAWTLRACHLCRCIFGA 145
           C +G  C +G      C CP  + GR C  D      G    HG   L      RC   A
Sbjct: 128 CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPA 187

Query: 146 LHCLPL 151
            +  PL
Sbjct: 188 GYTGPL 193



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 15/32 (46%), Positives = 16/32 (50%), Gaps = 4/32 (12%)

Query: 88  PRCCRNGGTC----VLGSFCVCPAHFTGRYCE 115
           P  CRNGGTC     L   C C   F G+ CE
Sbjct: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE 234



 Score = 28.9 bits (63), Expect = 3.7
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 17/80 (21%)

Query: 86  ARPRCCRN----------GGTCV--LGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWT 132
           A PRC R+           GTC   + SF C CP  + G +CE D       +  +G   
Sbjct: 880 AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTC 939

Query: 133 LRACH----LCRCIFGALHC 148
           +   +    LCR  +   HC
Sbjct: 940 VDGVNSFSCLCRPGYTGAHC 959



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 15/43 (34%), Positives = 18/43 (41%), Gaps = 9/43 (20%)

Query: 101 SFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC-HLCRCI 142
           + C CP  FTG  C+ D      GA          C HL RC+
Sbjct: 375 AICTCPPGFTGGACDQDVDECSIGA--------NPCEHLGRCV 409



 Score = 27.7 bits (60), Expect = 8.2
 Identities = 20/55 (36%), Positives = 22/55 (40%), Gaps = 5/55 (9%)

Query: 95  GTCVLG--SF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC--HLCRCIFG 144
           G CV G  SF C C   +TG  CE            HG   L     +LCRC  G
Sbjct: 557 GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSG 611


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score = 40.4 bits (93), Expect = 0.001
 Identities = 23/80 (28%), Positives = 30/80 (37%), Gaps = 9/80 (11%)

Query: 45  KHRQSPLNWTSSHFGEVTGSAEGWGPEEP---------LPYSWAFGEGASARPRCCRNGG 95
           + RQ  LNW      E     +   P  P          P     G+     P  C NGG
Sbjct: 65  RKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGG 124

Query: 96  TCVLGSFCVCPAHFTGRYCE 115
            CV    C+CP  F G++C+
Sbjct: 125 VCVKPDRCLCPPDFAGKFCQ 144



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 10/45 (22%)

Query: 83  GASARP--RCCRNGGTC-------VLGSF-CVCPAHFTGRYCEHD 117
           GAS +    C ++ G C       + GSF CVCPA F G  CE D
Sbjct: 629 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 673


>gi|110347431 latent transforming growth factor beta binding protein
           4 isoform a [Homo sapiens]
          Length = 1624

 Score = 40.4 bits (93), Expect = 0.001
 Identities = 23/80 (28%), Positives = 30/80 (37%), Gaps = 9/80 (11%)

Query: 45  KHRQSPLNWTSSHFGEVTGSAEGWGPEEP---------LPYSWAFGEGASARPRCCRNGG 95
           + RQ  LNW      E     +   P  P          P     G+     P  C NGG
Sbjct: 102 RKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGG 161

Query: 96  TCVLGSFCVCPAHFTGRYCE 115
            CV    C+CP  F G++C+
Sbjct: 162 VCVKPDRCLCPPDFAGKFCQ 181



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 10/45 (22%)

Query: 83  GASARP--RCCRNGGTC-------VLGSF-CVCPAHFTGRYCEHD 117
           GAS +    C ++ G C       + GSF CVCPA F G  CE D
Sbjct: 666 GASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 710


>gi|41393583 EGF-like-domain, multiple 7 [Homo sapiens]
          Length = 273

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 32/103 (31%), Positives = 40/103 (38%), Gaps = 16/103 (15%)

Query: 67  GWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGAL 126
           GW     LP +     GA+     CRNGG+CV    C CPA + G  C+ D    EC A 
Sbjct: 91  GWKRTSGLPGAC----GAAICQPPCRNGGSCVQPGRCRCPAGWRGDTCQSDV--DECSAR 144

Query: 127 EHG----AWTLRACHLCRCIFG------ALHCLPLQTPDRCDP 159
             G           + C+C  G         C+P   P R  P
Sbjct: 145 RGGCPQRCVNTAGSYWCQCWEGHSLSADGTLCVPKGGPPRVAP 187


>gi|7705889 EGF-like-domain, multiple 7 [Homo sapiens]
          Length = 273

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 32/103 (31%), Positives = 40/103 (38%), Gaps = 16/103 (15%)

Query: 67  GWGPEEPLPYSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGAL 126
           GW     LP +     GA+     CRNGG+CV    C CPA + G  C+ D    EC A 
Sbjct: 91  GWKRTSGLPGAC----GAAICQPPCRNGGSCVQPGRCRCPAGWRGDTCQSDV--DECSAR 144

Query: 127 EHG----AWTLRACHLCRCIFG------ALHCLPLQTPDRCDP 159
             G           + C+C  G         C+P   P R  P
Sbjct: 145 RGGCPQRCVNTAGSYWCQCWEGHSLSADGTLCVPKGGPPRVAP 187


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 82  EGASARPRCCRNGGTC--VLGSF-CVCPAHFTGRYCEHDQRRSECGALEHG--AWTLRAC 136
           E    R   CRNGG+C  + G++ C CPA F G +CE +    +    +HG    +    
Sbjct: 791 ERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGA 850

Query: 137 HLCRC--IFGALHCLPLQTP 154
           +LC C   F   HC  +  P
Sbjct: 851 YLCVCPESFFGYHCETVSDP 870



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 35/114 (30%), Positives = 42/114 (36%), Gaps = 10/114 (8%)

Query: 91  CRNGGTCVLG--SF-CVCPAHFTGRYCEHDQRRSECGALEHG--AWTLRACHLCRCIFGA 145
           C+NGGTC  G  SF C CPA F G  CE  Q   +    +HG          +C C  G 
Sbjct: 320 CQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGY 379

Query: 146 LHCLPLQTPDRCDPKDFLASHAHGPSAGGAPSLLLLLPCALLHRLLRPDAPAHP 199
                    D C P   L   +     G    L     CA   + LR +   HP
Sbjct: 380 TGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCL-----CAEPFKGLRCETGDHP 428



 Score = 37.7 bits (86), Expect = 0.008
 Identities = 27/81 (33%), Positives = 32/81 (39%), Gaps = 17/81 (20%)

Query: 91  CRNGGTCVLGS--FCVCPAHFTGRYCEHDQRRSECG----------ALEHGAWTLRACHL 138
           CRNGG C+  +   C CP  F G  CE +     C            +EHG   L  CH 
Sbjct: 474 CRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT 533

Query: 139 CRCIFGALHCLPLQTPDRCDP 159
                 A H LP  +P   DP
Sbjct: 534 DH---NASHSLP--SPCDSDP 549



 Score = 37.4 bits (85), Expect = 0.010
 Identities = 16/28 (57%), Positives = 17/28 (60%), Gaps = 3/28 (10%)

Query: 91  CRNGGTCVLGS---FCVCPAHFTGRYCE 115
           CRNGGTC        C CP  FTGR+CE
Sbjct: 589 CRNGGTCKEAGGEYHCSCPYRFTGRHCE 616



 Score = 36.2 bits (82), Expect = 0.023
 Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 7/69 (10%)

Query: 87  RPRCCRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHG--AWTLRACHLCRC 141
           R + C +GG+C   V G  C+C   + G +CE ++         +G     L   ++CRC
Sbjct: 758 RSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRC 817

Query: 142 IFG--ALHC 148
             G   +HC
Sbjct: 818 PAGFVGVHC 826



 Score = 35.0 bits (79), Expect = 0.051
 Identities = 15/28 (53%), Positives = 19/28 (67%), Gaps = 3/28 (10%)

Query: 91  CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
           C NGGTC   +G + C CP  F+GR+CE
Sbjct: 628 CHNGGTCFHYIGKYKCDCPPGFSGRHCE 655



 Score = 34.7 bits (78), Expect = 0.067
 Identities = 31/88 (35%), Positives = 37/88 (42%), Gaps = 21/88 (23%)

Query: 89  RCCRNGGTC----VLGS---FCVCPAHFTGRYCEHDQRRSEC--------GALEHGAWTL 133
           R C NGG C    V G+    C C + FTGR C  D   +EC        G   HG  + 
Sbjct: 276 RPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDV--NECASQPCQNGGTCTHGINSF 333

Query: 134 RACHLCRCIFGALHCLPLQTPDRCDPKD 161
           R    C   FG   C   Q+P  CD K+
Sbjct: 334 RC--QCPAGFGGPTCETAQSP--CDTKE 357



 Score = 33.9 bits (76), Expect = 0.11
 Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 4/57 (7%)

Query: 91  CRNGGTCV---LGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFG 144
           C NGGTCV    G  C CP  F G  C  ++   +C     G        LC+C  G
Sbjct: 438 CHNGGTCVDADQGYVCECPEGFMGLDC-RERVPDDCECRNGGRCLGANTTLCQCPLG 493



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 15/28 (53%), Positives = 17/28 (60%), Gaps = 3/28 (10%)

Query: 91   CRNGGTCVLGS---FCVCPAHFTGRYCE 115
            C+NGGTCV G+    C C   F GR CE
Sbjct: 1316 CQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 17/40 (42%), Positives = 19/40 (47%), Gaps = 6/40 (15%)

Query: 91  CRNGGTCV---LGSFCVCPAHFTGRYCEHDQRRSECGALE 127
           C NGGTC       FC C A + GR C   Q   +CG  E
Sbjct: 666 CVNGGTCEDRDTDFFCHCQAGYMGRRC---QAEVDCGPPE 702



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 12/82 (14%)

Query: 88  PRCCRNGGTCV--LGSF-CVCPAHFTGRYCEHDQRRSECGALEHGAWTLRAC------HL 138
           P  C NGG+CV  +G++ C+C   F G  CE          L         C      ++
Sbjct: 393 PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYV 452

Query: 139 CRCI--FGALHCLPLQTPDRCD 158
           C C   F  L C   + PD C+
Sbjct: 453 CECPEGFMGLDCRE-RVPDDCE 473



 Score = 28.5 bits (62), Expect = 4.8
 Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 9/75 (12%)

Query: 91  CRNGGTCVLGS---FCVCPAHFTGRYCEHDQ-RRSECGALEHGAWTLRAC--HLCRC--I 142
           C NGG+C        C CP  F G++CE  +      G   +G     A   + C C   
Sbjct: 550 CFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYR 609

Query: 143 FGALHCLPLQTPDRC 157
           F   HC  +  PD C
Sbjct: 610 FTGRHC-EIGKPDSC 623


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score = 39.7 bits (91), Expect = 0.002
 Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 6/69 (8%)

Query: 91   CRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCLP 150
            C++GGTC+ G+ C CP  F G  CE       C   E+G   L    +C+C  G     P
Sbjct: 1366 CQHGGTCLAGNLCTCPYGFVGPRCETMVCNRHC---ENGGQCLTP-DICQCKPGWYG--P 1419

Query: 151  LQTPDRCDP 159
              +   CDP
Sbjct: 1420 TCSTALCDP 1428



 Score = 35.8 bits (81), Expect = 0.030
 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 6/87 (6%)

Query: 91   CRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCLP 150
            C NGG+C   + C+CP  F G +C++      C   ++G   +R  ++C C  G  +   
Sbjct: 1430 CLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPPC---KNGGHCMRN-NVCVCREG--YTGR 1483

Query: 151  LQTPDRCDPKDFLASHAHGPSAGGAPS 177
                  CDP         GPS    PS
Sbjct: 1484 RFQKSICDPTCMNGGKCVGPSTCSCPS 1510



 Score = 34.3 bits (77), Expect = 0.088
 Identities = 17/54 (31%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 91   CRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFG 144
            C+N G C+  + C C     G  C+ +     C   +HG  T  A +LC C +G
Sbjct: 1334 CKNHGKCIKPNICQCLPGHGGATCDEEHCNPPC---QHGG-TCLAGNLCTCPYG 1383



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 11/25 (44%), Positives = 16/25 (64%)

Query: 91   CRNGGTCVLGSFCVCPAHFTGRYCE 115
            C+NGG C+  S C CP+ + G  C+
Sbjct: 1526 CKNGGECIAPSICHCPSSWEGVRCQ 1550



 Score = 32.7 bits (73), Expect = 0.26
 Identities = 12/24 (50%), Positives = 16/24 (66%)

Query: 91   CRNGGTCVLGSFCVCPAHFTGRYC 114
            C NGG CV  S C CP+ ++G+ C
Sbjct: 1494 CMNGGKCVGPSTCSCPSGWSGKRC 1517



 Score = 28.9 bits (63), Expect = 3.7
 Identities = 16/45 (35%), Positives = 21/45 (46%), Gaps = 7/45 (15%)

Query: 75   PYSWAFGEGASAR-PRC---CRNGGTCVLGSFCVCPAHFTGRYCE 115
            P SW   EG   + P C   C  GG C+  + C C   ++G  CE
Sbjct: 1541 PSSW---EGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCE 1582


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score = 39.7 bits (91), Expect = 0.002
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 14/75 (18%)

Query: 81   GEGASARPRC----CRNGGTC---VLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTL 133
            G+     P C    C+NGGTC   + G+ C C + F G  C+ D          HGA   
Sbjct: 4084 GQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGA--- 4140

Query: 134  RACHLCRCIFGALHC 148
                LC    G+ HC
Sbjct: 4141 ----LCENTHGSYHC 4151



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 12/29 (41%), Positives = 16/29 (55%), Gaps = 4/29 (13%)

Query: 91   CRNGGTC----VLGSFCVCPAHFTGRYCE 115
            C+NGG C      G +C C A + G +CE
Sbjct: 4022 CQNGGVCNPSPAGGYYCKCSALYIGTHCE 4050


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.482 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,147,988
Number of Sequences: 37866
Number of extensions: 585622
Number of successful extensions: 2735
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2097
Number of HSP's gapped (non-prelim): 654
length of query: 223
length of database: 18,247,518
effective HSP length: 98
effective length of query: 125
effective length of database: 14,536,650
effective search space: 1817081250
effective search space used: 1817081250
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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