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Search of human proteins with 239754018
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239754018 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
(338 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239754018 PREDICTED: hypothetical protein LOC100129791 [Homo ... 671 0.0
gi|239748549 PREDICTED: hypothetical protein LOC100129791 [Homo ... 662 0.0
gi|239742533 PREDICTED: hypothetical protein LOC100129791 [Homo ... 662 0.0
gi|157694505 LINE-1 type transposase domain containing 1 [Homo s... 164 1e-40
gi|239751946 PREDICTED: hypothetical protein XP_002348046 [Homo ... 134 9e-32
gi|239746429 PREDICTED: hypothetical protein XP_002344210 [Homo ... 134 9e-32
gi|239757430 PREDICTED: similar to lactation elevated 1 (predict... 134 1e-31
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 49 8e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 49 8e-06
gi|149363685 hypothetical protein LOC23379 [Homo sapiens] 48 1e-05
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 48 1e-05
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 48 1e-05
gi|122937514 unc-13 homolog C [Homo sapiens] 47 3e-05
gi|214010216 SMC6 protein [Homo sapiens] 47 3e-05
gi|13375848 SMC6 protein [Homo sapiens] 47 3e-05
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 45 1e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 44 2e-04
gi|50083279 centrosome protein 4 [Homo sapiens] 44 2e-04
gi|38044112 restin isoform b [Homo sapiens] 44 2e-04
gi|4506751 restin isoform a [Homo sapiens] 44 2e-04
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 44 2e-04
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 44 2e-04
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 44 2e-04
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 44 3e-04
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 44 3e-04
gi|92859701 myosin VI [Homo sapiens] 44 3e-04
gi|4504063 golgin 97 [Homo sapiens] 44 3e-04
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 43 4e-04
gi|148746195 trichohyalin [Homo sapiens] 43 4e-04
gi|56549111 optineurin [Homo sapiens] 43 4e-04
>gi|239754018 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 671 bits (1732), Expect = 0.0
Identities = 338/338 (100%), Positives = 338/338 (100%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ
Sbjct: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
Query: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA
Sbjct: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
Query: 121 MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD
Sbjct: 121 MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
Query: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV
Sbjct: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
Query: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK
Sbjct: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
Query: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM
Sbjct: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
>gi|239748549 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 662 bits (1709), Expect = 0.0
Identities = 335/338 (99%), Positives = 336/338 (99%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ
Sbjct: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
Query: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
TKGK+VENFEKNLEECITRITNTEKCLKELMELKTKAREL EECRSLRSRCDQLEERVSA
Sbjct: 61 TKGKKVENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLRSRCDQLEERVSA 120
Query: 121 MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
MEDEMNEMKQEGK REKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD
Sbjct: 121 MEDEMNEMKQEGKVREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
Query: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV
Sbjct: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
Query: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK
Sbjct: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
Query: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM
Sbjct: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
>gi|239742533 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 662 bits (1709), Expect = 0.0
Identities = 335/338 (99%), Positives = 336/338 (99%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ
Sbjct: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQ 60
Query: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
TKGK+VENFEKNLEECITRITNTEKCLKELMELKTKAREL EECRSLRSRCDQLEERVSA
Sbjct: 61 TKGKKVENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLRSRCDQLEERVSA 120
Query: 121 MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
MEDEMNEMKQEGK REKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD
Sbjct: 121 MEDEMNEMKQEGKVREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
Query: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV
Sbjct: 181 IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV 240
Query: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK
Sbjct: 241 TLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDK 300
Query: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM
Sbjct: 301 QMLRDFVTTRPALQELLKEALNMERNNRYQPLQNHAKM 338
>gi|157694505 LINE-1 type transposase domain containing 1 [Homo
sapiens]
Length = 865
Score = 164 bits (414), Expect = 1e-40
Identities = 96/265 (36%), Positives = 156/265 (58%), Gaps = 8/265 (3%)
Query: 57 EDIQTKGKEV-ENFEKNLEECITRITNTEKCLKELMELKTK---ARELCEECRSLRSRCD 112
E++ +K ++ E E+NL + I + + +E+ LK+ E+ L SR D
Sbjct: 600 EELTSKEADLTEETEENLRSSV--INSIREIKEEIGNLKSSHSGVLEIENSVDDLSSRMD 657
Query: 113 QLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGT 172
LEER+ ++ED++ E ++ K+I E+ ++I + + N+RLIG+PE E
Sbjct: 658 ILEERIDSLEDQIEEFSKDTMQMTKQIISKERQ-RDIEERSRSCNIRLIGIPEK-ESYEN 715
Query: 173 KLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLR 232
+ E+ +++II ENF L + ++++I R+ + +R TPRHI+V+F KEK++R
Sbjct: 716 RAEDIIKEIIDENFAELKKGSSLEIVSACRVPSKIDEKRLTPRHILVKFWNSSDKEKIIR 775
Query: 233 AAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEG 292
A+RE+ +T +G IRLTADLS +TL AR +W +F +L EK F PRI Y AK++F G
Sbjct: 776 ASRERREITYQGTRIRLTADLSLDTLDARSKWSNVFKVLLEKGFNPRILYPAKMAFDFRG 835
Query: 293 EIKYFIDKQMLRDFVTTRPALQELL 317
+ K F+ + RD+V P L+ELL
Sbjct: 836 KTKVFLSIEEFRDYVLHMPTLRELL 860
Score = 86.3 bits (212), Expect = 4e-17
Identities = 42/102 (41%), Positives = 69/102 (67%)
Query: 220 RFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPR 279
+F K++ KE++L+A+RE+ + +G + L ADLS+ TL ++W +FNIL+E +F+P+
Sbjct: 216 KFQKLKNKEEVLKASREEKVLMDEGAVLTLVADLSSATLDISKQWSNVFNILRENDFEPK 275
Query: 280 ISYAAKLSFISEGEIKYFIDKQMLRDFVTTRPALQELLKEAL 321
KL+F +GEIK F D Q LR F + + +++ELLK+ L
Sbjct: 276 FLCEVKLAFKCDGEIKTFSDLQSLRKFASQKSSVKELLKDVL 317
>gi|239751946 PREDICTED: hypothetical protein XP_002348046 [Homo
sapiens]
Length = 132
Score = 134 bits (338), Expect = 9e-32
Identities = 70/132 (53%), Positives = 93/132 (70%), Gaps = 3/132 (2%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRR---SNYSELRE 57
M K Q +K NSK Q+AS PPK+ +SSPA EQ W N+FDEL E GFRR +N S+L+E
Sbjct: 1 MRKNQCKKAENSKNQNASSPPKDHNSSPAREQDWTGNEFDELTEVGFRRWVITNSSKLKE 60
Query: 58 DIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEER 117
+ T+ KEV+N EK L++ +T I + EK + +LMELK AREL E S+ SR DQ EER
Sbjct: 61 HVLTQCKEVKNLEKRLDKLLTGINSLEKNINDLMELKNTARELREAYTSINSRIDQAEER 120
Query: 118 VSAMEDEMNEMK 129
+S +ED++NE+K
Sbjct: 121 ISEIEDQLNEIK 132
>gi|239746429 PREDICTED: hypothetical protein XP_002344210 [Homo
sapiens]
Length = 132
Score = 134 bits (338), Expect = 9e-32
Identities = 70/132 (53%), Positives = 93/132 (70%), Gaps = 3/132 (2%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRR---SNYSELRE 57
M K Q +K NSK Q+AS PPK+ +SSPA EQ W N+FDEL E GFRR +N S+L+E
Sbjct: 1 MRKNQCKKAENSKNQNASSPPKDHNSSPAREQDWTGNEFDELTEVGFRRWVITNSSKLKE 60
Query: 58 DIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEER 117
+ T+ KEV+N EK L++ +T I + EK + +LMELK AREL E S+ SR DQ EER
Sbjct: 61 HVLTQCKEVKNLEKRLDKLLTGINSLEKNINDLMELKNTARELREAYTSINSRIDQAEER 120
Query: 118 VSAMEDEMNEMK 129
+S +ED++NE+K
Sbjct: 121 ISEIEDQLNEIK 132
>gi|239757430 PREDICTED: similar to lactation elevated 1 (predicted)
[Homo sapiens]
Length = 132
Score = 134 bits (337), Expect = 1e-31
Identities = 70/132 (53%), Positives = 93/132 (70%), Gaps = 3/132 (2%)
Query: 1 MGKKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRR---SNYSELRE 57
M K Q +K NSK Q+AS PPK+ +SSPA EQ W N+FDEL E GFRR +N S+L+E
Sbjct: 1 MRKNQCKKAENSKNQNASSPPKDHNSSPAREQDWTGNEFDELTEIGFRRWVITNSSKLKE 60
Query: 58 DIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEER 117
+ T+ KEV+N EK L++ +T I + EK + +LMELK AREL E S+ SR DQ EER
Sbjct: 61 HVLTQCKEVKNLEKRLDKLLTGINSLEKNINDLMELKNTARELREAYTSINSRIDQAEER 120
Query: 118 VSAMEDEMNEMK 129
+S +ED++NE+K
Sbjct: 121 ISEIEDQLNEIK 132
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 48.5 bits (114), Expect = 8e-06
Identities = 56/281 (19%), Positives = 123/281 (43%), Gaps = 27/281 (9%)
Query: 52 YSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRC 111
Y+E + +++ E ++ K++ T EK KE++ LK+ EL ++ L+ +C
Sbjct: 762 YTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC 821
Query: 112 DQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENG 171
+ +E++ A+ E +K+ + +K +E+ + D + + N L+ V + E+
Sbjct: 822 GEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 881
Query: 172 TKLE--NTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEK 229
+ +I++ N N Q + + + SS + R KV+
Sbjct: 882 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR-------KVQDSNA 934
Query: 230 MLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFI 289
+ A KG+ + + L A++ A+ ++E I +K + YA +SF
Sbjct: 935 EILANYRKGQEEI----VTLHAEIKAQ----KKELDTIQECIK-------VKYAPIVSF- 978
Query: 290 SEGEIKYFIDKQMLRDFVTTRPALQELLKEAL--NMERNNR 328
E E K+ ++ L+D ++ + + +E + N + N++
Sbjct: 979 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1019
Score = 36.6 bits (83), Expect = 0.033
Identities = 57/288 (19%), Positives = 124/288 (43%), Gaps = 47/288 (16%)
Query: 50 SNYSELREDIQTKGKEVENFEKNLE---ECI----TRITNTEKCLKELMELKTKARELCE 102
+NY + +E+I T E++ +K L+ ECI I + E+C E K KA E
Sbjct: 938 ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC-----ERKFKATE--- 989
Query: 103 ECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPN-LRLI 161
+ L+ + + ++ S E+E+ + KQE +K I ++ L++ +++ + +
Sbjct: 990 --KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA 1047
Query: 162 GVPESDEENG---------TKLENTLQDIIQEN---------FPNLARQANIQIQEIQRM 203
++DE N T+++N + +++EN NL ++ ++ +++++ +
Sbjct: 1048 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1107
Query: 204 SQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLS---AETLQA 260
+ + + K E+K +E+ VT + + + S AE LQ
Sbjct: 1108 KKSLNG--------TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQI 1159
Query: 261 RREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDKQMLRDFVT 308
+ + I+K + K+ +S+ + + KQ L+ T
Sbjct: 1160 KEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1207
Score = 30.8 bits (68), Expect = 1.8
Identities = 21/92 (22%), Positives = 45/92 (48%), Gaps = 7/92 (7%)
Query: 54 ELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQ 113
EL QT E E +K LE T E ++ ++L+ + EC++L C++
Sbjct: 414 ELSLPSQTSYSENEILKKELE---AMRTFCESAKQDRLKLQNELAHKVAECKALALECER 470
Query: 114 L----EERVSAMEDEMNEMKQEGKFREKRIKR 141
+ +E++ +ED + ++++ E ++K+
Sbjct: 471 VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQ 502
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/181 (18%), Positives = 81/181 (44%), Gaps = 18/181 (9%)
Query: 83 TEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRI--- 139
TE+ +L +LK K E LR++ Q E V + + ++ +E K +K +
Sbjct: 526 TEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMC 585
Query: 140 ----KRNEQSLQEIWDYVKRPNLRL-IGVPESDEENGTKLENTLQDIIQENFPNLA---R 191
++ + + E+ K + +L + +P EN ++++L + + E L R
Sbjct: 586 EMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN---MKSSLSNEVNEKAKKLVEMER 642
Query: 192 QANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGR----VTLKGKPI 247
+ + EI+++ + + +A + ++K ++ + + E G+ +TLK + +
Sbjct: 643 EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTL 702
Query: 248 R 248
+
Sbjct: 703 Q 703
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 48.5 bits (114), Expect = 8e-06
Identities = 56/281 (19%), Positives = 123/281 (43%), Gaps = 27/281 (9%)
Query: 52 YSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRC 111
Y+E + +++ E ++ K++ T EK KE++ LK+ EL ++ L+ +C
Sbjct: 775 YTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC 834
Query: 112 DQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENG 171
+ +E++ A+ E +K+ + +K +E+ + D + + N L+ V + E+
Sbjct: 835 GEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 894
Query: 172 TKLE--NTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEK 229
+ +I++ N N Q + + + SS + R KV+
Sbjct: 895 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR-------KVQDSNA 947
Query: 230 MLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFI 289
+ A KG+ + + L A++ A+ ++E I +K + YA +SF
Sbjct: 948 EILANYRKGQEEI----VTLHAEIKAQ----KKELDTIQECIK-------VKYAPIVSF- 991
Query: 290 SEGEIKYFIDKQMLRDFVTTRPALQELLKEAL--NMERNNR 328
E E K+ ++ L+D ++ + + +E + N + N++
Sbjct: 992 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1032
Score = 36.6 bits (83), Expect = 0.033
Identities = 57/288 (19%), Positives = 124/288 (43%), Gaps = 47/288 (16%)
Query: 50 SNYSELREDIQTKGKEVENFEKNLE---ECI----TRITNTEKCLKELMELKTKARELCE 102
+NY + +E+I T E++ +K L+ ECI I + E+C E K KA E
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC-----ERKFKATE--- 1002
Query: 103 ECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPN-LRLI 161
+ L+ + + ++ S E+E+ + KQE +K I ++ L++ +++ + +
Sbjct: 1003 --KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA 1060
Query: 162 GVPESDEENG---------TKLENTLQDIIQEN---------FPNLARQANIQIQEIQRM 203
++DE N T+++N + +++EN NL ++ ++ +++++ +
Sbjct: 1061 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1120
Query: 204 SQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLS---AETLQA 260
+ + + K E+K +E+ VT + + + S AE LQ
Sbjct: 1121 KKSLNG--------TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQI 1172
Query: 261 RREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDKQMLRDFVT 308
+ + I+K + K+ +S+ + + KQ L+ T
Sbjct: 1173 KEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1220
Score = 30.8 bits (68), Expect = 1.8
Identities = 21/92 (22%), Positives = 45/92 (48%), Gaps = 7/92 (7%)
Query: 54 ELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQ 113
EL QT E E +K LE T E ++ ++L+ + EC++L C++
Sbjct: 427 ELSLPSQTSYSENEILKKELE---AMRTFCESAKQDRLKLQNELAHKVAECKALALECER 483
Query: 114 L----EERVSAMEDEMNEMKQEGKFREKRIKR 141
+ +E++ +ED + ++++ E ++K+
Sbjct: 484 VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQ 515
Score = 30.0 bits (66), Expect = 3.1
Identities = 34/181 (18%), Positives = 81/181 (44%), Gaps = 18/181 (9%)
Query: 83 TEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRI--- 139
TE+ +L +LK K E LR++ Q E V + + ++ +E K +K +
Sbjct: 539 TEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMC 598
Query: 140 ----KRNEQSLQEIWDYVKRPNLRL-IGVPESDEENGTKLENTLQDIIQENFPNLA---R 191
++ + + E+ K + +L + +P EN ++++L + + E L R
Sbjct: 599 EMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN---MKSSLSNEVNEKAKKLVEMER 655
Query: 192 QANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGR----VTLKGKPI 247
+ + EI+++ + + +A + ++K ++ + + E G+ +TLK + +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTL 715
Query: 248 R 248
+
Sbjct: 716 Q 716
>gi|149363685 hypothetical protein LOC23379 [Homo sapiens]
Length = 2266
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/159 (21%), Positives = 68/159 (42%), Gaps = 24/159 (15%)
Query: 50 SNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARE---------- 99
+ Y + +++Q +E N +EE + +I+ +KC +EL LK + E
Sbjct: 52 TEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQD 111
Query: 100 -------LCEEC-------RSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQS 145
+ EEC + L ++ +L+E + +++ E K EK K+ ++
Sbjct: 112 THQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQER 171
Query: 146 LQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQE 184
L E LR IG S + G+ + ++ +++E
Sbjct: 172 LDEFSKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKE 210
Score = 28.5 bits (62), Expect = 8.9
Identities = 29/149 (19%), Positives = 63/149 (42%), Gaps = 12/149 (8%)
Query: 68 NFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAM------ 121
+ ++NL E + + ++ + L T+ ++ C+E + R L +V M
Sbjct: 25 SLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISP 84
Query: 122 ----EDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT 177
++E+ +K E + ++ +K + + QE + VK L+ + E KL+
Sbjct: 85 LQKCQEELGSLKAELEEKKSSLKLYQDTHQE-YARVKEECLKSDAQKKKLEAKVKKLQEA 143
Query: 178 LQDIIQENFPNLARQANIQIQEIQRMSQR 206
Q+ F L + I +E ++ +R
Sbjct: 144 AVKQTQD-FKQLRNEKKILEKEFKKTQER 171
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 47.8 bits (112), Expect = 1e-05
Identities = 53/241 (21%), Positives = 110/241 (45%), Gaps = 33/241 (13%)
Query: 22 KECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRIT 81
+E S+ P +E ++ FDE+ A LR+ QT+G++V+ ++
Sbjct: 20 QEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQME--------- 70
Query: 82 NTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKR 141
LK L + K KA E+ ++ S ++ +E V + E+E++ +K R K I+
Sbjct: 71 -----LKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKN----RLKEIEH 121
Query: 142 NEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQ 201
N + ++ + +K + R + E++ ++LE ++ + Q + Q+ ++
Sbjct: 122 NLSKIMKLDNEIKALDSR----KKQMEKDNSELEEKMEKVFQ--------GTDEQLNDLY 169
Query: 202 RMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAA-REKGRVTLKGKPIRLTADLSAETLQA 260
QR + R R ++ ++E K R +EK + ++ ++L AD E ++A
Sbjct: 170 HNHQR--TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 227
Query: 261 R 261
R
Sbjct: 228 R 228
Score = 42.0 bits (97), Expect = 8e-04
Identities = 48/238 (20%), Positives = 97/238 (40%), Gaps = 32/238 (13%)
Query: 58 DIQTKGKEVENFEKNLEECIT---------RITNTEKCLKELMELKTKARELCEECRSLR 108
DI+ K K + + K++E I + T K + +L E + ++ E+ R +R
Sbjct: 807 DIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMR 866
Query: 109 SRCD-----------------QLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWD 151
D + EE E+ +K+ G+ + ++K Q L+E D
Sbjct: 867 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 926
Query: 152 YVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRR 211
+KR + +G + EE + L++ + R+ I ++ + +++
Sbjct: 927 NIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYY 986
Query: 212 ATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGK-----PIRLTADLSAETLQARREW 264
T I++F ++M E++ + R+ R T +G+ IR AD + RR +
Sbjct: 987 KTLDQAIMKFHSMKM-EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNY 1043
Score = 29.6 bits (65), Expect = 4.0
Identities = 31/172 (18%), Positives = 68/172 (39%), Gaps = 11/172 (6%)
Query: 49 RSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKEL-------MELKTKARELC 101
R+ + DIQ ++E E L + + + CL ++ MELK R++
Sbjct: 612 RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 671
Query: 102 EECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLI 161
++ L+ L+ V + E E + + +I+ N + +Q+ + ++
Sbjct: 672 QQAAKLQG--IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 729
Query: 162 GVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRAT 213
+ + T L+ Q ++E L+ + +EI+ ++ S T
Sbjct: 730 ELKSEKLQISTNLQRRQQ--LEEQTVELSTEVQSLYREIKDAKEQVSPLETT 779
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 47.8 bits (112), Expect = 1e-05
Identities = 53/241 (21%), Positives = 110/241 (45%), Gaps = 33/241 (13%)
Query: 22 KECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRIT 81
+E S+ P +E ++ FDE+ A LR+ QT+G++V+ ++
Sbjct: 159 QEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQME--------- 209
Query: 82 NTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKR 141
LK L + K KA E+ ++ S ++ +E V + E+E++ +K R K I+
Sbjct: 210 -----LKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKN----RLKEIEH 260
Query: 142 NEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQ 201
N + ++ + +K + R + E++ ++LE ++ + Q + Q+ ++
Sbjct: 261 NLSKIMKLDNEIKALDSR----KKQMEKDNSELEEKMEKVFQ--------GTDEQLNDLY 308
Query: 202 RMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAA-REKGRVTLKGKPIRLTADLSAETLQA 260
QR + R R ++ ++E K R +EK + ++ ++L AD E ++A
Sbjct: 309 HNHQR--TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 366
Query: 261 R 261
R
Sbjct: 367 R 367
Score = 42.0 bits (97), Expect = 8e-04
Identities = 48/238 (20%), Positives = 97/238 (40%), Gaps = 32/238 (13%)
Query: 58 DIQTKGKEVENFEKNLEECIT---------RITNTEKCLKELMELKTKARELCEECRSLR 108
DI+ K K + + K++E I + T K + +L E + ++ E+ R +R
Sbjct: 946 DIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMR 1005
Query: 109 SRCD-----------------QLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWD 151
D + EE E+ +K+ G+ + ++K Q L+E D
Sbjct: 1006 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 1065
Query: 152 YVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRR 211
+KR + +G + EE + L++ + R+ I ++ + +++
Sbjct: 1066 NIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYY 1125
Query: 212 ATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGK-----PIRLTADLSAETLQARREW 264
T I++F ++M E++ + R+ R T +G+ IR AD + RR +
Sbjct: 1126 KTLDQAIMKFHSMKM-EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNY 1182
Score = 29.6 bits (65), Expect = 4.0
Identities = 31/172 (18%), Positives = 68/172 (39%), Gaps = 11/172 (6%)
Query: 49 RSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKEL-------MELKTKARELC 101
R+ + DIQ ++E E L + + + CL ++ MELK R++
Sbjct: 751 RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 810
Query: 102 EECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLI 161
++ L+ L+ V + E E + + +I+ N + +Q+ + ++
Sbjct: 811 QQAAKLQG--IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 868
Query: 162 GVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRAT 213
+ + T L+ Q ++E L+ + +EI+ ++ S T
Sbjct: 869 ELKSEKLQISTNLQRRQQ--LEEQTVELSTEVQSLYREIKDAKEQVSPLETT 918
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 46.6 bits (109), Expect = 3e-05
Identities = 41/186 (22%), Positives = 87/186 (46%), Gaps = 22/186 (11%)
Query: 85 KCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQ 144
K L+ + +++T+ EL +L+ D++ V ++ E+ +++ G + +R R
Sbjct: 248 KELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRT-GFVQSRRETR--- 303
Query: 145 SLQEIWDYVK-------RPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQI 197
+I DY+K + +LR + V E E +E+ + I+ + I+I
Sbjct: 304 ---DIHDYIKHLGHMGSKASLRFLNVTE---ERFEYVESVVYQILIDKMGFSDAPNAIKI 357
Query: 198 QEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAET 257
+ QR+ + A PR I+V F + ++ +L+ + + LKG I ++ D+
Sbjct: 358 EFAQRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYK-----LKGTGIGISTDILTHD 412
Query: 258 LQARRE 263
++ R+E
Sbjct: 413 IRERKE 418
>gi|214010216 SMC6 protein [Homo sapiens]
Length = 1091
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/238 (19%), Positives = 101/238 (42%), Gaps = 26/238 (10%)
Query: 26 SSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEK 85
SS T ++ D D S S+L +++ K ++ N +++L I + E+
Sbjct: 651 SSENTRPKFLSRDVD---------SEISDLENEVENKTAQILNLQQHLSALEKDIKHNEE 701
Query: 86 CLKELM----ELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKR 141
LK ELK K R+ E R L + + ++ +EDE E K + K E+ +++
Sbjct: 702 LLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQ 761
Query: 142 NEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQ 201
+++++ +L+ + + ++ + K + + + + A+ ++ +
Sbjct: 762 QKENME---------HLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQK 812
Query: 202 RMSQRYSSRRATPRHII-VRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETL 258
R + Y ++ + + +++MKEK L + R P R+ + SA L
Sbjct: 813 RGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQIC---PERIEVEKSASIL 867
Score = 31.2 bits (69), Expect = 1.4
Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 13/99 (13%)
Query: 37 NDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCL----KELME 92
N EL + N ++ D Q +GK ++E+ +E + + ++ L KEL E
Sbjct: 788 NQLSELADPLKDELNLADSEVDNQKRGKR--HYEEKQKEHLDTLNKKKRELDMKEKELEE 845
Query: 93 LKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQE 131
++AR++C E ++E+ S ++ E+N ++Q+
Sbjct: 846 KMSQARQICPE-------RIEVEKSASILDKEINRLRQK 877
>gi|13375848 SMC6 protein [Homo sapiens]
Length = 1091
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/238 (19%), Positives = 101/238 (42%), Gaps = 26/238 (10%)
Query: 26 SSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEK 85
SS T ++ D D S S+L +++ K ++ N +++L I + E+
Sbjct: 651 SSENTRPKFLSRDVD---------SEISDLENEVENKTAQILNLQQHLSALEKDIKHNEE 701
Query: 86 CLKELM----ELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKR 141
LK ELK K R+ E R L + + ++ +EDE E K + K E+ +++
Sbjct: 702 LLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQ 761
Query: 142 NEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQ 201
+++++ +L+ + + ++ + K + + + + A+ ++ +
Sbjct: 762 QKENME---------HLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQK 812
Query: 202 RMSQRYSSRRATPRHII-VRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETL 258
R + Y ++ + + +++MKEK L + R P R+ + SA L
Sbjct: 813 RGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQIC---PERIEVEKSASIL 867
Score = 31.2 bits (69), Expect = 1.4
Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 13/99 (13%)
Query: 37 NDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCL----KELME 92
N EL + N ++ D Q +GK ++E+ +E + + ++ L KEL E
Sbjct: 788 NQLSELADPLKDELNLADSEVDNQKRGKR--HYEEKQKEHLDTLNKKKRELDMKEKELEE 845
Query: 93 LKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQE 131
++AR++C E ++E+ S ++ E+N ++Q+
Sbjct: 846 KMSQARQICPE-------RIEVEKSASILDKEINRLRQK 877
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 44.7 bits (104), Expect = 1e-04
Identities = 40/200 (20%), Positives = 86/200 (43%), Gaps = 12/200 (6%)
Query: 59 IQTKGKEVENFEKNLEECITRITNTEK--CLKELMELKTKARELCEECRSLRSRCDQLEE 116
+Q + + E ++L+E + NT K E+M+ +++ + EEC+SLR + ++
Sbjct: 978 LQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGR 1037
Query: 117 RVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLEN 176
++ A E+ + ++K +++ L E + R + + E E +LE
Sbjct: 1038 QLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEK 1097
Query: 177 TLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAARE 236
IQE + L ++ + + Q+M T ++ ++E+++ R+
Sbjct: 1098 ATTK-IQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKY---------LEERLIELLRD 1147
Query: 237 KGRVTLKGKPIRLTADLSAE 256
K + K + LSAE
Sbjct: 1148 KDALWQKSDALEFQQKLSAE 1167
Score = 33.1 bits (74), Expect = 0.36
Identities = 32/177 (18%), Positives = 75/177 (42%), Gaps = 10/177 (5%)
Query: 4 KQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKG 63
+Q T + K P P + + M+ ++L+ R+ E+ +
Sbjct: 376 QQKADTASDTKGRQEPIPSDAAQE-------MQELGEKLQALERERTKVEEVNRQ---QS 425
Query: 64 KEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMED 123
++E K L+ + E+ +KE+ L+ + +E L R +L S+ E+
Sbjct: 426 AQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEE 485
Query: 124 EMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQD 180
E+ E+++E K +++ + EQ ++ + ++ +L V + + + + +QD
Sbjct: 486 ELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQD 542
Score = 31.2 bits (69), Expect = 1.4
Identities = 33/139 (23%), Positives = 55/139 (39%), Gaps = 9/139 (6%)
Query: 33 SWMENDFDELREAGFRRSNY-SELREDIQTKGKEVEN--------FEKNLEECITRITNT 83
S N E + A R+ + LRED++ KE+E + K +E R N
Sbjct: 1061 SCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERND 1120
Query: 84 EKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNE 143
+K L +L +L + L E L D L ++ A+E + +E +
Sbjct: 1121 QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCL 1180
Query: 144 QSLQEIWDYVKRPNLRLIG 162
+E V+R + R+ G
Sbjct: 1181 DCKREFSWMVRRHHCRICG 1199
Score = 28.9 bits (63), Expect = 6.8
Identities = 33/173 (19%), Positives = 76/173 (43%), Gaps = 4/173 (2%)
Query: 41 ELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKAREL 100
EL AG + + +Q + E ++ L+E T ++ +E EL+ REL
Sbjct: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQE-EELRQANREL 621
Query: 101 CEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRL 160
+E +++ R LE ++ A++ + ++Q + + E I + L
Sbjct: 622 EKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASL 681
Query: 161 IGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQ-RYSSRRA 212
+ V ++ E K + ++ I ++ +Q ++++ Q++++ R+ RA
Sbjct: 682 LAVRKAKE--AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRA 732
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 44.3 bits (103), Expect = 2e-04
Identities = 41/220 (18%), Positives = 100/220 (45%), Gaps = 25/220 (11%)
Query: 40 DELREAGFRRSNYSELR----EDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKT 95
D++++ F+ S+ + E + + ++K + T+ NT K L+ +ELK+
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 96 K-ARELCEECRSLRSRCDQLEERVSA----MEDEMNEMKQEGKFREKRIKRNEQSLQEIW 150
K A E E+ L+ DQ +R MED+ ++M+++ E +K + E+
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 151 DYVKRPNLRLIGVPESDEENGTKLENTLQDIIQ--ENFPNLARQANIQIQE--------- 199
D++ + + + + E + + + ++++Q ++F L + + +++E
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
Query: 200 --IQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREK 237
+ M +++ H+ + V+ KE+ L+A ++
Sbjct: 1592 NQVYSMKAELETKKKELEHVNL---SVKSKEEELKALEDR 1628
Score = 38.1 bits (87), Expect = 0.011
Identities = 48/242 (19%), Positives = 100/242 (41%), Gaps = 34/242 (14%)
Query: 90 LMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEI 149
L E + K R+L +E + R+R +LE S++E + E K + K ++ +
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELE---SSLEKSLQENKNQSKDLAVHLEAEK------ 598
Query: 150 WDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSS 209
+ N + + E + L++ + E L +Q ++++++ ++
Sbjct: 599 ----NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 210 RRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFN 269
+ II + EM EK L ++ +K + + +E L+AR + +
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLE------KLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 270 ILKEKNFQPRISYAAKL------------SFISEGEIKYFIDKQMLRDFVTTRPALQELL 317
+LK++ + + AK+ S I E E+ ++ L+D + L+ LL
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN---QLELLL 765
Query: 318 KE 319
KE
Sbjct: 766 KE 767
Score = 37.7 bits (86), Expect = 0.015
Identities = 49/246 (19%), Positives = 107/246 (43%), Gaps = 40/246 (16%)
Query: 41 ELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCL--KELMELKTKAR 98
EL++A + + + + K E L++ + + TE+ L K++ E++ + +
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL-ETERILLTKQVAEVEAQKK 850
Query: 99 ELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNL 158
++C E L+ ++D M +++++ E+++K SL +++
Sbjct: 851 DVCTE----------LDAHKIQVQDLMQQLEKQNSEMEQKVK----SLTQVY-------- 888
Query: 159 RLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHII 218
ES E+G K + + I+ E + + Q +EI+ ++Q+ S++ + +
Sbjct: 889 ------ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942
Query: 219 VRF-TKVEMKEKMLRAAREKGR---VTLKGKPIRLTADLSAETLQARREWRPIFNILKEK 274
+ TK + +EK + ++K + TLK K + A L E E KEK
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ-----KEK 997
Query: 275 NFQPRI 280
F ++
Sbjct: 998 QFNAKM 1003
Score = 37.7 bits (86), Expect = 0.015
Identities = 62/273 (22%), Positives = 110/273 (40%), Gaps = 31/273 (11%)
Query: 57 EDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEE 116
+ Q G+E +N K EE I + N +K EL+TK +EL S++S+ EE
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKA--ELETKKKELEHVNLSVKSK----EE 1620
Query: 117 RVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLEN 176
+ A+ED + E + K E + ++ EQ + I +L+ E EE K
Sbjct: 1621 ELKALEDRL-ESESAAKLAELK-RKAEQKIAAI-------KKQLLSQMEEKEEQYKKGTE 1671
Query: 177 TLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAARE 236
+ + R+ +I ++++ + S PR E +E + +
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 237 KGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKLSFISEGEIKY 296
K T + K L +L+ + +R + + +F+ R Y +L + E K
Sbjct: 1732 K---TYEEKISVLQRNLTEKEKLLQRVGQEKEETV-SSHFEMRCQYQERLIKLEHAEAKQ 1787
Query: 297 FIDKQMLRDFVTTRPALQELLKEALNMERNNRY 329
D+ M+ LQE L+ E+N +Y
Sbjct: 1788 HEDQSMIGH-------LQEELE-----EKNKKY 1808
Score = 36.6 bits (83), Expect = 0.033
Identities = 33/145 (22%), Positives = 70/145 (48%), Gaps = 16/145 (11%)
Query: 36 ENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKT 95
+ + ++LRE E ++ K KE+ F+ ++EE EK L++L +T
Sbjct: 639 QTEMEKLREK-------CEQEKETLLKDKEII-FQAHIEEM------NEKTLEKLDVKQT 684
Query: 96 KARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKR 155
+ L E + +LEE +S ++D+ ++MKQE + + K + Q Q++ +K
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ--QQVDSIIKE 742
Query: 156 PNLRLIGVPESDEENGTKLENTLQD 180
+ + ++ ++ +LE L++
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKE 767
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 44.3 bits (103), Expect = 2e-04
Identities = 40/182 (21%), Positives = 81/182 (44%), Gaps = 15/182 (8%)
Query: 66 VENFEKNLEECITRITNTEKCL-KELMELKTKARELCEECRSLRSRCDQLEERVSAMEDE 124
++ K+LE+ I + T++ + E++ L K +LC+E + QLE + +
Sbjct: 280 LQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLET 339
Query: 125 MNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQE 184
++ E K K IKR +Q++ + + + L L + E +L +++
Sbjct: 340 ADKELGEAK---KEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL------LVKS 390
Query: 185 NFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVT--L 242
+ + Q QE QR+S++ S T R + + ++ ++ + R R R+ L
Sbjct: 391 DLETVVHQLE---QEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFL 447
Query: 243 KG 244
KG
Sbjct: 448 KG 449
Score = 28.9 bits (63), Expect = 6.8
Identities = 34/166 (20%), Positives = 71/166 (42%), Gaps = 9/166 (5%)
Query: 81 TNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDE-MNEMKQEGKFREKRI 139
T+ +KC +E +LK + + + L ER+ ++++ ++ + Q +++ I
Sbjct: 105 TSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSI 164
Query: 140 KRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQE 199
Q +Q I + V + VP+ D+ L + IQE +Q Q+QE
Sbjct: 165 AFRRQRMQ-IDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQE-----LQQEVHQLQE 218
Query: 200 IQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGK 245
+++ S R + I +R ++E L R ++L+ +
Sbjct: 219 --KLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 43.9 bits (102), Expect = 2e-04
Identities = 50/288 (17%), Positives = 124/288 (43%), Gaps = 22/288 (7%)
Query: 35 MENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELK 94
ME+ ++L+EA + L+ + K ++NF L+ ++ + + K E K
Sbjct: 682 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741
Query: 95 TKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVK 154
++ ++L ++ + + LE +A + + + +E + RE ++ +++L E+ +
Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 155 RPNLRLIGVPE---SDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRR 211
L + E E ++ ++Q+ + + Q N+ +++++ + +
Sbjct: 802 TLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNMLSSDLEKLRENLADME 860
Query: 212 ATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNIL 271
A +F + + +E+ L A+EK + + ++++ D S++ + E R L
Sbjct: 861 A-------KFREKDEREEQLIKAKEKLENDI-AEIMKMSGDNSSQLTKMNDELR-----L 907
Query: 272 KEKNFQPRISYAAKLSFISEGEIKYFIDKQMLRDFVTTRPALQELLKE 319
KE++ + +L E F+ K + V + QE K+
Sbjct: 908 KERDVE-----ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
Score = 35.8 bits (81), Expect = 0.056
Identities = 25/102 (24%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 35 MENDFDELREAGFRR-SNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMEL 93
++N+ D L+E + ++ +E + + +++E F K +E + L L E
Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132
Query: 94 KTKARELCEECRSLRSRCDQLEERVSAMEDEMNEM-KQEGKF 134
K E R + +LEE S + +++ EM K+E KF
Sbjct: 1133 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF 1174
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 43.9 bits (102), Expect = 2e-04
Identities = 50/288 (17%), Positives = 124/288 (43%), Gaps = 22/288 (7%)
Query: 35 MENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELK 94
ME+ ++L+EA + L+ + K ++NF L+ ++ + + K E K
Sbjct: 717 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776
Query: 95 TKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVK 154
++ ++L ++ + + LE +A + + + +E + RE ++ +++L E+ +
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 155 RPNLRLIGVPE---SDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRR 211
L + E E ++ ++Q+ + + Q N+ +++++ + +
Sbjct: 837 TLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNMLSSDLEKLRENLADME 895
Query: 212 ATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNIL 271
A +F + + +E+ L A+EK + + ++++ D S++ + E R L
Sbjct: 896 A-------KFREKDEREEQLIKAKEKLENDI-AEIMKMSGDNSSQLTKMNDELR-----L 942
Query: 272 KEKNFQPRISYAAKLSFISEGEIKYFIDKQMLRDFVTTRPALQELLKE 319
KE++ + +L E F+ K + V + QE K+
Sbjct: 943 KERDVE-----ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985
Score = 35.8 bits (81), Expect = 0.056
Identities = 25/102 (24%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 35 MENDFDELREAGFRR-SNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMEL 93
++N+ D L+E + ++ +E + + +++E F K +E + L L E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167
Query: 94 KTKARELCEECRSLRSRCDQLEERVSAMEDEMNEM-KQEGKF 134
K E R + +LEE S + +++ EM K+E KF
Sbjct: 1168 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF 1209
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 43.9 bits (102), Expect = 2e-04
Identities = 43/184 (23%), Positives = 85/184 (46%), Gaps = 20/184 (10%)
Query: 41 ELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKT----K 96
ELR R + +++ + +Q + +++K EE I + +TEK L E LKT +
Sbjct: 5008 ELRSQRMSRDSGAQV-DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHE 5066
Query: 97 ARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRP 156
A E E ++L S + E++ A+E++ +++++ G K +S+ +W R
Sbjct: 5067 AEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATL--SRSMTTVWQRWTR- 5123
Query: 157 NLRLIGVPESDEENGTKLENTLQDIIQE--NFPNLARQANIQIQEIQRMSQRYSSRRATP 214
LR + + E L+D + E F N ++A I ++Q S+ +A+
Sbjct: 5124 -LRAVAQDQ---------EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASK 5173
Query: 215 RHII 218
++
Sbjct: 5174 AELL 5177
Score = 31.6 bits (70), Expect = 1.1
Identities = 42/273 (15%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 22 KECSSSPATEQSWMENDFDELRE---------AGFRRSNYSELREDIQTKGKE--VENFE 70
+ C + PA EQ +++ L E +G R+ +L + ++ + +E ++ +
Sbjct: 5960 ESCEADPA-EQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 6018
Query: 71 KNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMED---EMNE 127
+E + + +T+ L + + ++ + ++ ++E++V A+ +
Sbjct: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
Query: 128 MKQEGKFREK--------RIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT-- 177
+ EGK K +++R + SL E+ + L + G + EE+ L T
Sbjct: 6079 LLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS 6138
Query: 178 --LQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAR 235
+Q+ + + +Q +Q+ + + Q + +++ R + R ++ ++ +
Sbjct: 6139 PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSG 6198
Query: 236 EKG-RVTLKGKPIRLTADLSAETLQARREWRPI 267
+ G + + + + + + S+ Q R +W +
Sbjct: 6199 DAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL 6231
Score = 29.3 bits (64), Expect = 5.2
Identities = 36/208 (17%), Positives = 80/208 (38%), Gaps = 22/208 (10%)
Query: 40 DELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARE 99
+E ++ G + S + + T EVE N +C+ + L+EL+ + +E
Sbjct: 1205 NEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQE 1264
Query: 100 LCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLR 159
E+ + + E +Q +++ KR +++ + +
Sbjct: 1265 QAEKILD---------------TENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
Query: 160 LIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQ------RYSSRRAT 213
G+P+ E KLE+TL D ++ + R+ + +++ +R RY + +
Sbjct: 1310 EGGLPDRGHEELRKLESTL-DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS 1368
Query: 214 PRHIIVRFTKVEMKEKMLRAAREKGRVT 241
+ F+ +E L +E + T
Sbjct: 1369 SHERFLSFSSLESLSSELEQTKEFSKRT 1396
Score = 28.5 bits (62), Expect = 8.9
Identities = 44/215 (20%), Positives = 89/215 (41%), Gaps = 24/215 (11%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
K+ S +TG+SK A + ++ ++ D + + G ++ Y+ L + I +
Sbjct: 2437 KESSDRTGDSKVLEAKLHDLQNILDSVSDG---QSKLDAVTQEG--QTLYAHLSKQIVSS 2491
Query: 63 GKEV-----ENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEER 117
+E E F+ L++C+ + C EL + ++ R L ++EER
Sbjct: 2492 IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE-------DQHRKLNLWIHEMEER 2544
Query: 118 VSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLI---GVPESDEENGTKL 174
+ + + E KQ ++ + + E L E+ R +L + G S+E +G
Sbjct: 2545 FNT--ENLGESKQHIPEKKNEVHKVEMFLGEL--LAARESLDKLSQRGQLLSEEGHGAGQ 2600
Query: 175 ENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSS 209
E L + + NL R +++ Q Q + +
Sbjct: 2601 EGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEA 2635
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 43.9 bits (102), Expect = 2e-04
Identities = 43/184 (23%), Positives = 85/184 (46%), Gaps = 20/184 (10%)
Query: 41 ELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKT----K 96
ELR R + +++ + +Q + +++K EE I + +TEK L E LKT +
Sbjct: 5079 ELRSQRMSRDSGAQV-DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHE 5137
Query: 97 ARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRP 156
A E E ++L S + E++ A+E++ +++++ G K +S+ +W R
Sbjct: 5138 AEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATL--SRSMTTVWQRWTR- 5194
Query: 157 NLRLIGVPESDEENGTKLENTLQDIIQE--NFPNLARQANIQIQEIQRMSQRYSSRRATP 214
LR + + E L+D + E F N ++A I ++Q S+ +A+
Sbjct: 5195 -LRAVAQDQ---------EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASK 5244
Query: 215 RHII 218
++
Sbjct: 5245 AELL 5248
Score = 31.6 bits (70), Expect = 1.1
Identities = 42/273 (15%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 22 KECSSSPATEQSWMENDFDELRE---------AGFRRSNYSELREDIQTKGKE--VENFE 70
+ C + PA EQ +++ L E +G R+ +L + ++ + +E ++ +
Sbjct: 6031 ESCEADPA-EQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYR 6089
Query: 71 KNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMED---EMNE 127
+E + + +T+ L + + ++ + ++ ++E++V A+ +
Sbjct: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
Query: 128 MKQEGKFREK--------RIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT-- 177
+ EGK K +++R + SL E+ + L + G + EE+ L T
Sbjct: 6150 LLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS 6209
Query: 178 --LQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAR 235
+Q+ + + +Q +Q+ + + Q + +++ R + R ++ ++ +
Sbjct: 6210 PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSG 6269
Query: 236 EKG-RVTLKGKPIRLTADLSAETLQARREWRPI 267
+ G + + + + + + S+ Q R +W +
Sbjct: 6270 DAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL 6302
Score = 29.3 bits (64), Expect = 5.2
Identities = 36/208 (17%), Positives = 80/208 (38%), Gaps = 22/208 (10%)
Query: 40 DELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARE 99
+E ++ G + S + + T EVE N +C+ + L+EL+ + +E
Sbjct: 1198 NEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQE 1257
Query: 100 LCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLR 159
E+ + + E +Q +++ KR +++ + +
Sbjct: 1258 QAEKILD---------------TENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
Query: 160 LIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQ------RYSSRRAT 213
G+P+ E KLE+TL D ++ + R+ + +++ +R RY + +
Sbjct: 1303 EGGLPDRGHEELRKLESTL-DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS 1361
Query: 214 PRHIIVRFTKVEMKEKMLRAAREKGRVT 241
+ F+ +E L +E + T
Sbjct: 1362 SHERFLSFSSLESLSSELEQTKEFSKRT 1389
Score = 28.5 bits (62), Expect = 8.9
Identities = 44/215 (20%), Positives = 89/215 (41%), Gaps = 24/215 (11%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
K+ S +TG+SK A + ++ ++ D + + G ++ Y+ L + I +
Sbjct: 2430 KESSDRTGDSKVLEAKLHDLQNILDSVSDG---QSKLDAVTQEG--QTLYAHLSKQIVSS 2484
Query: 63 GKEV-----ENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEER 117
+E E F+ L++C+ + C EL + ++ R L ++EER
Sbjct: 2485 IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE-------DQHRKLNLWIHEMEER 2537
Query: 118 VSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLI---GVPESDEENGTKL 174
+ + + E KQ ++ + + E L E+ R +L + G S+E +G
Sbjct: 2538 FNT--ENLGESKQHIPEKKNEVHKVEMFLGEL--LAARESLDKLSQRGQLLSEEGHGAGQ 2593
Query: 175 ENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSS 209
E L + + NL R +++ Q Q + +
Sbjct: 2594 EGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEA 2628
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 43.9 bits (102), Expect = 2e-04
Identities = 41/186 (22%), Positives = 86/186 (46%), Gaps = 16/186 (8%)
Query: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
TKG+ EK ++E ++ +KEL +LK +E +E R+LR++ LE+
Sbjct: 459 TKGE----LEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLR 514
Query: 121 MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLE----- 175
EDE+++ K+ I R + +Q + D VK + + +E E
Sbjct: 515 TEDELSKYKE-------IINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESL 567
Query: 176 NTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAR 235
N+L + +Q++ ++ + + +R++ + + ++ + +F KV E L++
Sbjct: 568 NSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC 627
Query: 236 EKGRVT 241
E+ + T
Sbjct: 628 EQMKQT 633
Score = 38.9 bits (89), Expect = 0.007
Identities = 27/122 (22%), Positives = 60/122 (49%), Gaps = 4/122 (3%)
Query: 31 EQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKEL 90
+++ ++N D+++ A + +++I+ +EVE+ + + I + K EL
Sbjct: 529 QKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESEL 588
Query: 91 M----ELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSL 146
+ L +K +L E SL+S+ D++ S ++ + +MKQ E R+ + E+
Sbjct: 589 LLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR 648
Query: 147 QE 148
+E
Sbjct: 649 KE 650
Score = 31.2 bits (69), Expect = 1.4
Identities = 59/296 (19%), Positives = 114/296 (38%), Gaps = 61/296 (20%)
Query: 14 KQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNL 73
K+ A K C T Q E +EL +A R + EL + +Q K ++E +
Sbjct: 424 KEEADQIRKNCQDMIKTYQESEEIKSNEL-DAKLRVTK-GELEKQMQEKSDQLEMHHAKI 481
Query: 74 EECITRITNTEKCLKELMELKTKARELCEECRSLRSR----------------------- 110
+E ++ + EL L+TK + C E LR+
Sbjct: 482 KELEDLKRTFKEGMDELRTLRTKVK--CLEDERLRTEDELSKYKEIINRQKAEIQNLLDK 539
Query: 111 ---CDQLEERVSAMEDEMNEMKQEGKFREKRI----------KRNEQSLQEIWDYVKRPN 157
DQL+E++ + E+ +K+E + I ++ E L + + N
Sbjct: 540 VKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKN 599
Query: 158 LRLIGVPESDEE-------NGTKLENTLQDIIQENF---PNLARQANIQIQEIQRMSQRY 207
+L S + + ++L++ + + Q N L ++ ++ +E+Q +
Sbjct: 600 AQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAEL 659
Query: 208 SSRRATPRHIIVRFTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARRE 263
+ R+ + + T+VE + L R K ++K DL+ + QARR+
Sbjct: 660 ACRQTEVKAL---STQVEELKDELVTQRRKHASSIK--------DLTKQLQQARRK 704
Score = 28.9 bits (63), Expect = 6.8
Identities = 53/256 (20%), Positives = 111/256 (43%), Gaps = 48/256 (18%)
Query: 54 ELREDIQTKGKEVE-NFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCD 112
+L I+ KEV+ + ++ + + +T ++ KE+ + +A + CEE R + +
Sbjct: 253 QLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEK---E 309
Query: 113 QLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNL---RLIGVPESDEE 169
+ + E E ++++E + EK+++ + L++ + +K+ + RL + E+ E
Sbjct: 310 AMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEG 369
Query: 170 NGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEK 229
T+L I+EI ++ + +S H+I KV+ +
Sbjct: 370 ETTRL----------------------IREIDKLKEDINS------HVI----KVKWAQN 397
Query: 230 MLRAAREKGRVT---LKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQPRISYAAKL 286
L+A + + T LK +LT E Q R+ + + +E AKL
Sbjct: 398 KLKAEMDSHKETKDKLKETTTKLT-QAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKL 456
Query: 287 SFISEGEIKYFIDKQM 302
+++GE ++KQM
Sbjct: 457 R-VTKGE----LEKQM 467
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 43.5 bits (101), Expect = 3e-04
Identities = 60/280 (21%), Positives = 110/280 (39%), Gaps = 35/280 (12%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
+KQ +K +K+ P + P T ++ DF E L+ DI
Sbjct: 467 EKQYKKEVEAKQ--LEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAIL 524
Query: 63 GKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAM- 121
+E+ C + N EK K L ++K + +E + +C +L E +
Sbjct: 525 RQEI---------CTMKNDNLEKENKYLKDIK-----IAKETNAALEKCIKLNEEMITKT 570
Query: 122 ----EDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT 177
+ E+N++K E + + ++S +++ ++ RL EN K E
Sbjct: 571 AFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSEN-VKTERN 629
Query: 178 LQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREK 237
L+ LA + I E +MS S + + +K+++K L+ K
Sbjct: 630 LK---------LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRK 680
Query: 238 GRVTLKGKPIRLTA---DLSAETLQARREWRPIFNILKEK 274
R TL+ K + L DLS +T Q +E + ++ + K
Sbjct: 681 TRDTLRKKSLALETVQNDLS-QTQQQIKEMKEMYQSAEAK 719
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 43.5 bits (101), Expect = 3e-04
Identities = 60/280 (21%), Positives = 110/280 (39%), Gaps = 35/280 (12%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
+KQ +K +K+ P + P T ++ DF E L+ DI
Sbjct: 467 EKQYKKEVEAKQ--LEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAIL 524
Query: 63 GKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAM- 121
+E+ C + N EK K L ++K + +E + +C +L E +
Sbjct: 525 RQEI---------CTMKNDNLEKENKYLKDIK-----IAKETNAALEKCIKLNEEMITKT 570
Query: 122 ----EDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT 177
+ E+N++K E + + ++S +++ ++ RL EN K E
Sbjct: 571 AFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSEN-VKTERN 629
Query: 178 LQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREK 237
L+ LA + I E +MS S + + +K+++K L+ K
Sbjct: 630 LK---------LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRK 680
Query: 238 GRVTLKGKPIRLTA---DLSAETLQARREWRPIFNILKEK 274
R TL+ K + L DLS +T Q +E + ++ + K
Sbjct: 681 TRDTLRKKSLALETVQNDLS-QTQQQIKEMKEMYQSAEAK 719
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 43.5 bits (101), Expect = 3e-04
Identities = 38/163 (23%), Positives = 70/163 (42%), Gaps = 5/163 (3%)
Query: 53 SELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCD 112
S L++ K+++N E +++ + +I +T +++ + + EE S +
Sbjct: 858 SVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKK 917
Query: 113 QLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGT 172
Q EE + EM++E K RE+ KR + +E +R L + + +EE
Sbjct: 918 QQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEE-----RRMKLEMEAKRKQEEEERK 972
Query: 173 KLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPR 215
K E+ + I E LARQ + Q+ + Q R R
Sbjct: 973 KREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALR 1015
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 43.5 bits (101), Expect = 3e-04
Identities = 64/316 (20%), Positives = 135/316 (42%), Gaps = 39/316 (12%)
Query: 37 NDFDELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTK 96
++ DEL GF++ S+++ + K + + E+ LE ++ T++ ELM
Sbjct: 168 DEMDELE--GFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQE---ELMNSNQM 222
Query: 97 ARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRP 156
+ +L ++ L+ LEE+ D + K + + +++ EQ LQ + +
Sbjct: 223 SSDLSQKLEELQRHYSTLEEQ----RDHVIASKTGAESKITALEQKEQELQALIQQLSID 278
Query: 157 NLRLIGVPESDE-------ENGTKLENTLQDII--QENFPNLARQANIQIQEIQRMSQR- 206
++ + E E LE L+ + +E+ L ++ + Q ++ Q+
Sbjct: 279 LQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQL 338
Query: 207 YSSRRATPRHIIVRFTKVEMKEKMLRAARE-----KGRVTLKGKPIRLTADLSAETLQAR 261
++R + + I T+V E+ L+A+ E KG V + I+ A + E+ +
Sbjct: 339 LAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQ 398
Query: 262 REWRPIFNILKEKNFQPRISYAAKLSFISEGEIKYFIDKQMLRDFVTTRPALQELLKE-- 319
++ + E+ F R + A + ++ +++ D T +++L +E
Sbjct: 399 QQ-----ALALEQQFLER-TQALEAQIVA-------LERTRAADQTTAEQGMRQLEQENA 445
Query: 320 ALNMERNNRYQPLQNH 335
AL RN + LQNH
Sbjct: 446 ALKECRNEYERSLQNH 461
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 43.1 bits (100), Expect = 4e-04
Identities = 54/237 (22%), Positives = 106/237 (44%), Gaps = 24/237 (10%)
Query: 57 EDIQTKGKEVENFEKNLEECITRITNTEKCLKELME-LKTKARELCEECRSLRSRCDQL- 114
E ++ + + + E+ L E R+ E+ L+E E L+ + LCE+ LR ++L
Sbjct: 199 ERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLC 258
Query: 115 --EERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPE---SDEE 169
EER+ E+ + E ++ +E+R+ E+ L+E + + RL E EE
Sbjct: 259 EQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEE 318
Query: 170 NGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEK 229
+ E L + QE P R ++E++++ ++ R+ ++ R +E E+
Sbjct: 319 RLREQEERLCE--QEKLPGQER----LLEEVEKLLEQ-ERRQEEQERLLERERLLEEVEE 371
Query: 230 MLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNI----LKEKNFQPRISY 282
+L R L+ + RL + + L+ RE + + L E+ +PR +
Sbjct: 372 LLEQER------LRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGF 422
Score = 36.6 bits (83), Expect = 0.033
Identities = 29/146 (19%), Positives = 67/146 (45%), Gaps = 17/146 (11%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
+K R K Q+A P E + P+ + + + LR+++++
Sbjct: 131 QKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDET--------------NHLRKELESV 176
Query: 63 GKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAME 122
G++++ +N + ++ + ++ + L E + + RE E R R + EER+ E
Sbjct: 177 GRQLQAEVEN-NQMLSLLNRRQE--ERLREQEERLREQEERLREQEERLCEQEERLREQE 233
Query: 123 DEMNEMKQEGKFREKRIKRNEQSLQE 148
+ + E ++ +E+R++ +E+ L E
Sbjct: 234 ERLREQEERLCEQEERLREHEERLCE 259
Score = 31.2 bits (69), Expect = 1.4
Identities = 31/120 (25%), Positives = 55/120 (45%), Gaps = 20/120 (16%)
Query: 54 ELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELME-LKTKARELCEECRSLRSR-- 110
E E ++ + + + E+ L E R+ E+ L E E L+ + LCE+ LR +
Sbjct: 266 EQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEE 325
Query: 111 --CDQ---------LEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLR 159
C+Q LEE +E E + +QE R+ E+ L+E+ + +++ LR
Sbjct: 326 RLCEQEKLPGQERLLEEVEKLLEQERRQEEQE------RLLERERLLEEVEELLEQERLR 379
Score = 28.9 bits (63), Expect = 6.8
Identities = 31/153 (20%), Positives = 70/153 (45%), Gaps = 8/153 (5%)
Query: 92 ELKTKARELCEECR-----SLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSL 146
EL++ R+L E SL +R + EER+ E+ + E ++ + +E+R+ E+ L
Sbjct: 172 ELESVGRQLQAEVENNQMLSLLNR--RQEERLREQEERLREQEERLREQEERLCEQEERL 229
Query: 147 QEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQR 206
+E + ++ RL E E+ +L + + ++ ++ + QE +R+ ++
Sbjct: 230 REQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQE-ERLCEQ 288
Query: 207 YSSRRATPRHIIVRFTKVEMKEKMLRAAREKGR 239
R + + ++ +E+ L E+ R
Sbjct: 289 EERLREQEERLCEQEERLREQEERLCEQEERLR 321
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 43.1 bits (100), Expect = 4e-04
Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 42/271 (15%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPAT-EQSWMENDFDELREAGFRRSNYSELREDIQT 61
++Q R+ ++QS E E+ W + E +E RR+ +L+
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQ--EWQEREERRAEEEQLQS---C 196
Query: 62 KGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQL------- 114
KG E E F EE + R +EL+EL+ K RE E+ + R R D++
Sbjct: 197 KGHETEEFPD--EEQLRR--------RELLELRRKGRE--EKQQQRRERQDRVFQEEEEK 244
Query: 115 --EERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGT 172
+R + + E ++++E R++ ++ E+ L+++ +R LR E ++
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL----ERQELRRERQEEEQQQQRL 300
Query: 173 KLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLR 232
+ E L+ +E + QE +R Q ++ R +R + E +E+ LR
Sbjct: 301 RREQQLRRKQEEE--------RREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 233 AAREKGRVTLKGKPIRLTADLSAETLQARRE 263
+E+ R + + +R + Q RRE
Sbjct: 353 REQEEER---REQQLRREQEEERREQQLRRE 380
Score = 40.0 bits (92), Expect = 0.003
Identities = 59/265 (22%), Positives = 107/265 (40%), Gaps = 15/265 (5%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
K+Q R+ +++ +E ++ + D L+E RR + E R D + +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS-QEQRRDQKWR 875
Query: 63 GKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAME 122
+ E ++ + E+ KE L+ + EL E R R R +Q + E
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY---RE 932
Query: 123 DEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENTLQDII 182
+E + ++E RE+R KR Q + Y K L+ + ++ G + E +
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERER--QYRKDKKLQ----QKEEQLLGEEPEKRRR--- 983
Query: 183 QENFPNLARQANIQIQEIQRMSQRYSSRRAT--PRHIIVRFTKVEMKEKMLRAAREKGRV 240
QE + +Q +E Q + + RR R + + +E++LR REK R+
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043
Query: 241 TLKGKPIRLTADLSAETLQARREWR 265
+ + R +L E Q E R
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEER 1068
Score = 38.1 bits (87), Expect = 0.011
Identities = 52/243 (21%), Positives = 108/243 (44%), Gaps = 27/243 (11%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
+KQ + +++ + EQ + + +E RE RR E RE +
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQ-LRREQEERREQQLRREQEEERREQQLRR 366
Query: 63 GKEVENFEKNL--EECITRITNT--EKCLKELMELKTKARELCEECRSLRSRCDQLEERV 118
+E E E+ L E+ + R E+ L+ +L+ + ++L E + R + + E+++
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQL 425
Query: 119 SA-MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDEENGTKLENT 177
E+E +E K E + RE+R+KR + +E D++KR +EE +
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQ---EERRDWLKR-----------EEETERHEQER 471
Query: 178 LQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREK 237
+ ++ + R+ ++++E +R Q+ R +R + E +E+ L+ E+
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQ------ERREQQLRREQEERREQRLKRQEEE 525
Query: 238 GRV 240
R+
Sbjct: 526 ERL 528
Score = 35.4 bits (80), Expect = 0.073
Identities = 70/348 (20%), Positives = 131/348 (37%), Gaps = 37/348 (10%)
Query: 3 KKQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTK 62
+++ RK + +S P K + + F + + R+ + R+D K
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 63 GKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAME 122
+E E + EE +++ E+ K +E + R+ E+ ME
Sbjct: 1557 FREEEQLRQEREE--QQLSRQERDRKFRLEEQKVRRQ---------------EQERKFME 1599
Query: 123 DEMNEMKQEG-----KFREKRIKRNEQSLQEIWD-YVKRPNLRLIGVPESDEENGTKLEN 176
DE +QEG + R+++ + +EQ LQE + + R + E + + E
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 177 TLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMKEKMLRAARE 236
L+ F R+ +QE + R R R + + E + K L+ ++
Sbjct: 1660 QLRHDRDRKF----REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 237 KGRVTLKGK---PIRLTADLSAETLQARREWRPIF---NILKEKNFQPRISYAAKLSFIS 290
R L+ K +L + E L+ + +R I + E+ Q F
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 291 EGEIKYFIDKQMLRDFVTTRPALQELLKEALNMER-NNRYQPLQNHAK 337
E +++ ++Q LR + R +E E L ER + +P Q K
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREE---EQLRQEREEQQLRPQQRDGK 1820
Score = 31.6 bits (70), Expect = 1.1
Identities = 41/194 (21%), Positives = 82/194 (42%), Gaps = 18/194 (9%)
Query: 35 MENDFDELREAGFRRSNYSE-----LREDIQTKGKEVENFEKNL----EECITRITNTEK 85
+ + +E RE +R E LR + Q + ++ E E+ L E+ + + ++
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 86 CLKELMELKTKARELCEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNE-- 143
+E E + + + EE R R + +Q E ++ E E ++ + RE+R+KR E
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626
Query: 144 ----QSLQEIWDYVKRPNLRLIGVPESDEENGTKL---ENTLQDIIQENFPNLARQANIQ 196
Q L + + +R +L + E K E L+ ++ R+ +
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 197 IQEIQRMSQRYSSR 210
+E ++ +R SR
Sbjct: 687 EEEQEQARERIKSR 700
Score = 31.6 bits (70), Expect = 1.1
Identities = 51/291 (17%), Positives = 113/291 (38%), Gaps = 35/291 (12%)
Query: 4 KQSRKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKG 63
++ + ++Q P++ Q E + + E R R++++ +
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY 1140
Query: 64 KEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSAMED 123
+E E ++ E+ + E + EL+ + RE Q EE++ E
Sbjct: 1141 REEEEVQQEEEQLLRE----EPEKRRRQELERQYRE--------EEELQQEEEQLLREEQ 1188
Query: 124 EMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPES--------------DEE 169
E ++E ++RE+ + ++ Q D +R +L+ PE + E
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 170 NGTKLENT-LQD-IIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVRFTKVEMK 227
+LE++ L+D Q++ +L + + +E +R + R + R + E K
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308
Query: 228 EKMLRAAREKGRVTLKGKPIRLTADLSAETLQARREWRPIFNILKEKNFQP 278
+ ++ EK + +R + + R++R +L+E+ QP
Sbjct: 1309 RRDRKSQEEK-------QLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 29.3 bits (64), Expect = 5.2
Identities = 46/223 (20%), Positives = 90/223 (40%), Gaps = 13/223 (5%)
Query: 41 ELREAGFRRSNYSELREDIQTKGKEVENFEKNLEECITRITNTEKCLKELMELKTKAREL 100
E RE +R E R D + +E E E+ + + E+ + ++L+ + R
Sbjct: 441 ERREQRLKREQ--EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 101 CEECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRL 160
+E R + R +Q E R E +QE + R ++ R+EQ L+ + + +L
Sbjct: 499 QQERREQQLRREQEERR------EQRLKRQEEEERLQQRLRSEQQLRREQEERRE---QL 549
Query: 161 IGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVR 220
+ E + E L+ +E L ++ + Q+ + Q + R + R
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 221 FTKVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETLQARRE 263
+ E +E+ L+ RE+ + + ++ Q RRE
Sbjct: 610 LEQEERREQRLK--REEPEEERRQQLLKSEEQEERRQQQLRRE 650
Score = 29.3 bits (64), Expect = 5.2
Identities = 53/260 (20%), Positives = 92/260 (35%), Gaps = 46/260 (17%)
Query: 4 KQSRKTGNSKKQSASPPPKECSSSPATEQS---WMENDFDELREAGFRRSNYSELREDIQ 60
+QS+ +KQ +E +S W E E R+ E R D
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE------ERAHRQQQEEEQRRDFT 768
Query: 61 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLRSRCDQLEERVSA 120
+ + E E+ + R L+E E + +A E Q E+R
Sbjct: 769 WQWQAEEKSERGRQRLSARPP-----LREQRERQLRAEER-----------QQREQRFLP 812
Query: 121 MEDEMNEMKQEGKFREKRI-----------KRNEQSLQEIWDYVKRPNLRLIGVPESD-- 167
E+E + +++ + REK + + Q LQE D ++ R +
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 168 ------EENGTKLENTL--QDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIV 219
EE + +TL + +QE + + +E+QR + R+ R
Sbjct: 873 KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE 932
Query: 220 RFTKVEMKEKMLRAAREKGR 239
+ +E++LR REK R
Sbjct: 933 EEQLQQEEEQLLREEREKRR 952
>gi|56549111 optineurin [Homo sapiens]
Length = 577
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/219 (25%), Positives = 100/219 (45%), Gaps = 30/219 (13%)
Query: 48 RRSNYSELREDIQTKGK-EVENFEKNLEECI---TRITNTE--KCLKELMELKTKARELC 101
+ SN SE+ + QT+G E EN E+ E + N + KEL E TK E
Sbjct: 267 KTSNRSEI--ETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAE 324
Query: 102 EECRSLRSRCDQLEERVSAMEDEMNEMKQEGKFREKRIK-RNEQSLQEIWDYVKRPNLRL 160
+ L+ +C LE + SA+ E+NE KQE + K+++ + E L EI
Sbjct: 325 LMKKRLQEKCQALERKNSAIPSELNE-KQELVYTNKKLELQVESMLSEI----------- 372
Query: 161 IGVPESDEENGTKLENTLQDIIQENFPNLARQANIQIQEIQRMSQRYSSRRATPRHIIVR 220
E+ T+ E + ++Q L ++ N ++ I+ ++++ S + R ++
Sbjct: 373 -----KMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEK--VDRAVLKE 425
Query: 221 FT-KVEMKEKMLRAAREKGRVTLKGKPIRLTADLSAETL 258
+ K+E+ EK L A+++ +K + DL T+
Sbjct: 426 LSEKLELAEKAL-ASKQLQMDEMKQTIAKQEEDLETMTI 463
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,539,591
Number of Sequences: 37866
Number of extensions: 557159
Number of successful extensions: 4773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 199
Number of HSP's successfully gapped in prelim test: 498
Number of HSP's that attempted gapping in prelim test: 3078
Number of HSP's gapped (non-prelim): 1789
length of query: 338
length of database: 18,247,518
effective HSP length: 103
effective length of query: 235
effective length of database: 14,347,320
effective search space: 3371620200
effective search space used: 3371620200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.