Search of human proteins with 239750386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239750386 PREDICTED: chromosome 12 open reading frame 64
[Homo sapiens]
         (2250 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239750386 PREDICTED: chromosome 12 open reading frame 64 [Hom...  4890   0.0  
gi|239755901 PREDICTED: chromosome 12 open reading frame 64 [Hom...  4887   0.0  
gi|239744688 PREDICTED: hypothetical protein LOC283310 [Homo sap...  4887   0.0  
gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]            1167   0.0  
gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]            1167   0.0  
gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]            1167   0.0  
gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]            1160   0.0  
gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]            1160   0.0  
gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]            1160   0.0  
gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens]    597   e-170
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]        578   e-164
gi|116284392 mucin 2 precursor [Homo sapiens]                         555   e-157
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]      546   e-155
gi|161019170 mucin 5AC [Homo sapiens]                                 531   e-150
gi|134031945 SCO-spondin [Homo sapiens]                               463   e-130
gi|151301154 mucin 6, gastric [Homo sapiens]                          447   e-125
gi|239750277 PREDICTED: hypothetical protein XP_002347351 [Homo ...   400   e-110
gi|239744587 PREDICTED: hypothetical protein XP_002343203 [Homo ...   400   e-110
gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]             337   8e-92
gi|16554449 zonadhesin isoform 3 [Homo sapiens]                       324   7e-88
gi|27881494 zonadhesin isoform 6 [Homo sapiens]                       324   7e-88
gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo ...   319   2e-86
gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]        319   2e-86
gi|239757282 PREDICTED: similar to Fc fragment of IgG binding pr...   303   1e-81
gi|134268640 tectorin alpha precursor [Homo sapiens]                  300   1e-80
gi|239757286 PREDICTED: similar to Fc fragment of IgG binding pr...   268   6e-71
gi|239755776 PREDICTED: similar to Mucin-19 [Homo sapiens]            247   1e-64
gi|37693519 BMP-binding endothelial regulator precursor protein ...   159   2e-38
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]   144   7e-34
gi|239757284 PREDICTED: similar to Fc fragment of IgG binding pr...   142   3e-33

>gi|239750386 PREDICTED: chromosome 12 open reading frame 64 [Homo
            sapiens]
          Length = 2250

 Score = 4890 bits (12683), Expect = 0.0
 Identities = 2250/2250 (100%), Positives = 2250/2250 (100%)

Query: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60
            MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR
Sbjct: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60

Query: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120
            DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR
Sbjct: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120

Query: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180
            SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS
Sbjct: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180

Query: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240
            GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT
Sbjct: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300
            PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360
            RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH
Sbjct: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360

Query: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420
            CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC
Sbjct: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420

Query: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480
            PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI
Sbjct: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480

Query: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540
            TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG
Sbjct: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540

Query: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600
            ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV
Sbjct: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600

Query: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660
            PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA
Sbjct: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660

Query: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720
            HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC
Sbjct: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720

Query: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780
            NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA
Sbjct: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780

Query: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840
            VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG
Sbjct: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900
            MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN
Sbjct: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900

Query: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960
            DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL
Sbjct: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960

Query: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020
            WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP
Sbjct: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020

Query: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080
            DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC
Sbjct: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080

Query: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140
            LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT
Sbjct: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140

Query: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200
            SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE
Sbjct: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200

Query: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260
            LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS
Sbjct: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260

Query: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320
            SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD
Sbjct: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320

Query: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380
            EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP
Sbjct: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380

Query: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440
            QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR
Sbjct: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560
            NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG
Sbjct: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560

Query: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620
            IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV
Sbjct: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620

Query: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680
            TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY
Sbjct: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680

Query: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740
            VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV
Sbjct: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740

Query: 1741 CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800
            CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP
Sbjct: 1741 CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800

Query: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860
            DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS
Sbjct: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860

Query: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920
            CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF
Sbjct: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920

Query: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV 1980
            LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV
Sbjct: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV 1980

Query: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE 2040
            MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE
Sbjct: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE 2040

Query: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100
            CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV
Sbjct: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100

Query: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR 2160
            YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR
Sbjct: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR 2160

Query: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220
            EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR
Sbjct: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220

Query: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250
            NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN
Sbjct: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250


>gi|239755901 PREDICTED: chromosome 12 open reading frame 64 [Homo
            sapiens]
          Length = 2250

 Score = 4887 bits (12677), Expect = 0.0
 Identities = 2248/2250 (99%), Positives = 2250/2250 (100%)

Query: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60
            MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR
Sbjct: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60

Query: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120
            DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR
Sbjct: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120

Query: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180
            SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS
Sbjct: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180

Query: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240
            GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT
Sbjct: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300
            PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360
            RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH
Sbjct: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360

Query: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420
            CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC
Sbjct: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420

Query: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480
            PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI
Sbjct: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480

Query: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540
            TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG
Sbjct: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540

Query: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600
            ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV
Sbjct: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600

Query: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660
            PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA
Sbjct: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660

Query: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720
            HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC
Sbjct: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720

Query: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780
            NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA
Sbjct: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780

Query: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840
            VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG
Sbjct: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900
            MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN
Sbjct: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900

Query: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960
            DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL
Sbjct: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960

Query: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020
            WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP
Sbjct: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020

Query: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080
            DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC
Sbjct: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080

Query: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140
            LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT
Sbjct: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140

Query: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200
            SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE
Sbjct: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200

Query: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260
            LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS
Sbjct: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260

Query: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320
            SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD
Sbjct: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320

Query: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380
            EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP
Sbjct: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380

Query: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440
            QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR
Sbjct: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560
            NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG
Sbjct: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560

Query: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620
            IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV
Sbjct: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620

Query: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680
            TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY
Sbjct: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680

Query: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740
            VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV
Sbjct: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740

Query: 1741 CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800
            CKVGT+LHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP
Sbjct: 1741 CKVGTVLHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800

Query: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860
            DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS
Sbjct: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860

Query: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920
            CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF
Sbjct: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920

Query: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV 1980
            LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV
Sbjct: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV 1980

Query: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE 2040
            MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE
Sbjct: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE 2040

Query: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100
            CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV
Sbjct: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100

Query: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR 2160
            YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKM+EGIVKLYNEGCCKICKR
Sbjct: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMSEGIVKLYNEGCCKICKR 2160

Query: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220
            EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR
Sbjct: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220

Query: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250
            NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN
Sbjct: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250


>gi|239744688 PREDICTED: hypothetical protein LOC283310 [Homo sapiens]
          Length = 2250

 Score = 4887 bits (12677), Expect = 0.0
 Identities = 2248/2250 (99%), Positives = 2249/2250 (99%)

Query: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60
            MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR
Sbjct: 1    MLKRTNGCQKITFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGR 60

Query: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120
            DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR
Sbjct: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120

Query: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180
            SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS
Sbjct: 121  SISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180

Query: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240
            GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT
Sbjct: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT 240

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300
            PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC
Sbjct: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYC 300

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360
            RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH
Sbjct: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360

Query: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420
            CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC
Sbjct: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420

Query: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480
            PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI
Sbjct: 421  PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSI 480

Query: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540
            TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG
Sbjct: 481  TLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDG 540

Query: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600
            ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV
Sbjct: 541  ERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHV 600

Query: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660
            PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA
Sbjct: 601  PVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALA 660

Query: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720
            HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC
Sbjct: 661  HYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGC 720

Query: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780
            NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA
Sbjct: 721  NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSA 780

Query: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840
            VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG
Sbjct: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRG 840

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900
            MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN
Sbjct: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDN 900

Query: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960
            DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL
Sbjct: 901  DIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITIL 960

Query: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020
            WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP
Sbjct: 961  WDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020

Query: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080
            DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC
Sbjct: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080

Query: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140
            LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT
Sbjct: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMT 1140

Query: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200
            SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE
Sbjct: 1141 SRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLE 1200

Query: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260
            LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS
Sbjct: 1201 LWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSS 1260

Query: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320
            SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD
Sbjct: 1261 SFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILD 1320

Query: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380
            EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP
Sbjct: 1321 EVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEP 1380

Query: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440
            QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR
Sbjct: 1381 QKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCR 1440

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL
Sbjct: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560
            NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG
Sbjct: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTG 1560

Query: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620
            IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV
Sbjct: 1561 IIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEV 1620

Query: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680
            TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY
Sbjct: 1621 TMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAY 1680

Query: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740
            VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV
Sbjct: 1681 VALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV 1740

Query: 1741 CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800
            CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP
Sbjct: 1741 CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEP 1800

Query: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860
            DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS
Sbjct: 1801 DCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLS 1860

Query: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920
            CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF
Sbjct: 1861 CCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEF 1920

Query: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLV 1980
            LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENL+
Sbjct: 1921 LTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLI 1980

Query: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIE 2040
            MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCY IE
Sbjct: 1981 MPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYAIE 2040

Query: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100
            CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV
Sbjct: 2041 CLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVV 2100

Query: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR 2160
            YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR
Sbjct: 2101 YAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKR 2160

Query: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220
            EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR
Sbjct: 2161 EERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVR 2220

Query: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250
            NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN
Sbjct: 2221 NLSVPLYCSGNGTEIMYTLQEPIDCTCQWN 2250


>gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2852

 Score = 1167 bits (3019), Expect = 0.0
 Identities = 548/1385 (39%), Positives = 803/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 39   FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 98

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 99   GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 154

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 155  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 214

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 215  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 274

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 275  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 334

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 335  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 394

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 395  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 454

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 455  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 514

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 515  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 574

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 575  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 634

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 635  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 694

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 695  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 754

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 755  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 811

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 812  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 868

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 869  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 928

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 929  FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 988

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 989  ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1107

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1108 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1167

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1168 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1227

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1228 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1287

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1288 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1347

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P VEGC+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1348 FQTCRDPRAASCRDVPRVEGCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1407

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1408 LPPSQ 1412



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 1941 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 1994

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 1995 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2054

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2055 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2114

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2115 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2173

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2174 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2232

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2233 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2291

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2292 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2351

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2352 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2411

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2412 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2471

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2472 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2531

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2532 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2589

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2590 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2649

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2650 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2709

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2710 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2769

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2770 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2829

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2830 CATNATWVPYTVQEPTDCACQWS 2852



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2004 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2049

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2050 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2106

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2107 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2159

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2160 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2219

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2220 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2267

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2268 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2324

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2325 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2381

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2382 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2440

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2441 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2474



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 354  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 405

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 406  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 429

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 430  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 458

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 459  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 512

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 513  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 571

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 572  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 627

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 628  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 687

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 688  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 744

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 745  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 773



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 73   PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 130

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 131  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 181

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 182  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 235

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 236  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 294

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 295  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 349

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 350  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 400

Query: 1761 CAC 1763
            C C
Sbjct: 401  CPC 403



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2052

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2053 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2103

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2104 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2163

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2164 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2221

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2222 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2269

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2270 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2327

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2328 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2363



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2030 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2089

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2090 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2148

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2149 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2208

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2209 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2263

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2264 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2300



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 713  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 770

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 771  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 825

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 826  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 885

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 886  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 945

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 946  VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 997

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 998  VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1054

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1055 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1110

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1111 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1170


>gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2852

 Score = 1167 bits (3019), Expect = 0.0
 Identities = 548/1385 (39%), Positives = 803/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 39   FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 98

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 99   GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 154

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 155  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 214

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 215  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 274

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 275  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 334

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 335  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 394

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 395  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 454

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 455  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 514

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 515  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 574

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 575  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 634

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 635  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 694

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 695  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 754

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 755  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 811

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 812  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 868

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 869  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 928

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 929  FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 988

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 989  ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1107

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1108 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1167

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1168 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1227

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1228 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1287

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1288 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1347

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P VEGC+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1348 FQTCRDPRAASCRDVPRVEGCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1407

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1408 LPPSQ 1412



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 1941 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 1994

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 1995 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2054

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2055 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2114

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2115 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2173

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2174 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2232

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2233 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2291

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2292 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2351

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2352 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2411

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2412 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2471

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2472 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2531

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2532 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2589

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2590 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2649

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2650 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2709

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2710 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2769

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2770 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2829

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2830 CATNATWVPYTVQEPTDCACQWS 2852



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2004 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2049

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2050 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2106

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2107 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2159

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2160 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2219

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2220 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2267

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2268 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2324

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2325 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2381

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2382 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2440

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2441 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2474



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 354  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 405

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 406  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 429

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 430  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 458

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 459  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 512

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 513  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 571

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 572  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 627

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 628  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 687

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 688  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 744

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 745  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 773



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 73   PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 130

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 131  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 181

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 182  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 235

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 236  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 294

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 295  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 349

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 350  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 400

Query: 1761 CAC 1763
            C C
Sbjct: 401  CPC 403



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2052

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2053 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2103

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2104 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2163

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2164 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2221

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2222 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2269

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2270 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2327

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2328 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2363



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2030 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2089

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2090 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2148

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2149 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2208

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2209 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2263

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2264 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2300



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 713  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 770

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 771  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 825

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 826  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 885

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 886  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 945

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 946  VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 997

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 998  VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1054

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1055 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1110

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1111 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1170


>gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2852

 Score = 1167 bits (3019), Expect = 0.0
 Identities = 548/1385 (39%), Positives = 803/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 39   FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 98

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 99   GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 154

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 155  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 214

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 215  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 274

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 275  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 334

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 335  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 394

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 395  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 454

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 455  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 514

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 515  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 574

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 575  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 634

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 635  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 694

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 695  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 754

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 755  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 811

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 812  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 868

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 869  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 928

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 929  FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 988

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 989  ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1047

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1048 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1107

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1108 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1167

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1168 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1227

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1228 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1287

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1288 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1347

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P VEGC+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1348 FQTCRDPRAASCRDVPRVEGCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1407

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1408 LPPSQ 1412



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 1941 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 1994

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 1995 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2054

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2055 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2114

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2115 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2173

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2174 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2232

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2233 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2291

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2292 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2351

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2352 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2411

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2412 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2471

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2472 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2531

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2532 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2589

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2590 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2649

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2650 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2709

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2710 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2769

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2770 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2829

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2830 CATNATWVPYTVQEPTDCACQWS 2852



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2004 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2049

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2050 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2106

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2107 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2159

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2160 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2219

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2220 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2267

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2268 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2324

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2325 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2381

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2382 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2440

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2441 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2474



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 354  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 405

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 406  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 429

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 430  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 458

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 459  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 512

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 513  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 571

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 572  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 627

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 628  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 687

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 688  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 744

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 745  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 773



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 73   PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 130

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 131  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 181

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 182  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 235

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 236  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 294

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 295  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 349

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 350  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 400

Query: 1761 CAC 1763
            C C
Sbjct: 401  CPC 403



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2007 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2052

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2053 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2103

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2104 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2163

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2164 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2221

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2222 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2269

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2270 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2327

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2328 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2363



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2030 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2089

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2090 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2148

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2149 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2208

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2209 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2263

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2264 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2300



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 713  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 770

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 771  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 825

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 826  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 885

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 886  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 945

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 946  VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 997

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 998  VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1054

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1055 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1110

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1111 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1170


>gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2924

 Score = 1160 bits (3001), Expect = 0.0
 Identities = 545/1385 (39%), Positives = 800/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 111  FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 170

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 171  GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 226

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 227  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 286

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 287  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 346

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 347  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 406

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 407  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 466

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 467  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 526

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 527  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 586

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 587  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 646

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 647  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 706

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 707  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 766

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 767  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 826

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 827  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 883

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 884  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 940

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 941  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 1000

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 1001 FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 1060

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 1061 ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1179

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1180 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1239

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1240 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1299

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1300 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1359

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1360 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1419

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P    C+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1420 FQTCRDPRAASCRDVPRGRSCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1479

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1480 LPPSQ 1484



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 2013 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 2066

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 2067 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2126

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2127 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2186

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2187 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2245

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2246 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2304

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2305 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2363

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2364 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2423

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2424 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2483

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2484 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2543

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2544 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2603

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2604 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2661

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2662 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2721

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2722 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2781

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2782 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2841

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2842 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2901

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2902 CATNATWVPYTVQEPTDCACQWS 2924



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2076 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2121

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2122 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2178

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2179 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2231

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2232 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2291

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2292 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2339

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2340 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2396

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2397 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2453

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2454 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2512

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2513 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2546



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 426  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 477

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 478  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 501

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 502  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 530

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 531  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 584

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 585  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 643

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 644  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 699

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 700  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 759

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 760  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 816

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 817  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 845



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 145  PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 202

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 203  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 253

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 254  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 307

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 308  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 366

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 367  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 421

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 422  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 472

Query: 1761 CAC 1763
            C C
Sbjct: 473  CPC 475



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2124

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2125 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2175

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2176 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2235

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2236 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2293

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2294 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2341

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2342 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2399

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2400 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2435



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2102 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2161

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2162 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2220

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2221 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2280

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2281 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2335

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2336 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2372



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 785  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 842

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 843  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 897

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 898  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 957

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 958  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 1017

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 1018 VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 1069

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 1070 VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1126

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1127 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1182

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1183 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1242


>gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2924

 Score = 1160 bits (3001), Expect = 0.0
 Identities = 545/1385 (39%), Positives = 800/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 111  FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 170

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 171  GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 226

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 227  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 286

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 287  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 346

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 347  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 406

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 407  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 466

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 467  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 526

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 527  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 586

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 587  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 646

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 647  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 706

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 707  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 766

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 767  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 826

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 827  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 883

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 884  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 940

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 941  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 1000

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 1001 FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 1060

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 1061 ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1179

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1180 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1239

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1240 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1299

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1300 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1359

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1360 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1419

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P    C+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1420 FQTCRDPRAASCRDVPRGRSCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1479

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1480 LPPSQ 1484



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 2013 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 2066

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 2067 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2126

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2127 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2186

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2187 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2245

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2246 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2304

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2305 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2363

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2364 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2423

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2424 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2483

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2484 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2543

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2544 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2603

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2604 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2661

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2662 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2721

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2722 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2781

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2782 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2841

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2842 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2901

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2902 CATNATWVPYTVQEPTDCACQWS 2924



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2076 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2121

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2122 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2178

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2179 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2231

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2232 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2291

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2292 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2339

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2340 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2396

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2397 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2453

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2454 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2512

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2513 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2546



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 426  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 477

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 478  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 501

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 502  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 530

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 531  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 584

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 585  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 643

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 644  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 699

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 700  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 759

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 760  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 816

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 817  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 845



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 145  PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 202

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 203  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 253

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 254  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 307

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 308  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 366

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 367  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 421

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 422  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 472

Query: 1761 CAC 1763
            C C
Sbjct: 473  CPC 475



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2124

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2125 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2175

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2176 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2235

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2236 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2293

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2294 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2341

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2342 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2399

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2400 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2435



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2102 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2161

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2162 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2220

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2221 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2280

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2281 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2335

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2336 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2372



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 785  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 842

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 843  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 897

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 898  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 957

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 958  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 1017

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 1018 VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 1069

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 1070 VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1126

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1127 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1182

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1183 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1242


>gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2924

 Score = 1160 bits (3001), Expect = 0.0
 Identities = 545/1385 (39%), Positives = 800/1385 (57%), Gaps = 72/1385 (5%)

Query: 24   YECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFP 83
            + C NG  C     CDC+ F A G RCQ++ N G  RD IC+ WGQ+H ETFDG+YYY  
Sbjct: 111  FSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLS 170

Query: 84   GNCSYIFAKDCGDLEPR---YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIK 140
            G  SY      G  EP    +++ VHN P+C  S Y+C R++SLFF  ++EI +   E+ 
Sbjct: 171  GKGSYTLV---GRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHL-AKEVT 226

Query: 141  KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGN 200
              G+ + LP  +G   +++LA Y++V+    F+LAWDG S +Y+K+S +  G + GLCGN
Sbjct: 227  HGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGN 286

Query: 201  YNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPA-FEAIF 259
             N    DD +      T+D+  F +SW  Q P+      T S    PC    P   + ++
Sbjct: 287  NNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVY 346

Query: 260  FKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYPIQ 318
             +C+ LL+ PF +CH Y+ P  + ASC +DLC++  D  T+CRA  EYARAC+ AG P+Q
Sbjct: 347  EQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQ 406

Query: 319  DWRDDFPACTDKCDD-SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGT 377
             WR     CT  C + +F + +CI+CCP +C     C+ S + C+DGCYCP+GL+ ++G 
Sbjct: 407  GWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG 466

Query: 378  CISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDG 437
            C++   CPC FHG  Y  GS ++++C  C C  G W C+   CP +CSV GD HFTTFDG
Sbjct: 467  CVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDG 526

Query: 438  RHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRG 497
            R Y+F   CQYIL K      FT+TLQ APC  N    C+QS+++IL  D  +QVTL + 
Sbjct: 527  RRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQA 586

Query: 498  GQILTSPNQGF---NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRR 554
            G +L            +   EI+ LSS+F+ ++T  G+++L+  +G R+Y+Q+   W   
Sbjct: 587  GDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVED 646

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIG 614
            T+GLCGTFNGN +DDFLSP G+ E TPQL  N+W+  S C   V    +DPC+++ Q   
Sbjct: 647  TVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAAS 706

Query: 615  YAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPI 673
            Y+   C V+  E+FAPC  ++SP  Y++ CR DAC+CG  CLC  LAHYA+LC +HG+P+
Sbjct: 707  YSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPV 766

Query: 674  DFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCS---------DDCAEGCNCPE 724
            DFR ++  CA+ C+    Y  C + C  +C  L+SPE C          D+C EGC CP 
Sbjct: 767  DFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPP 826

Query: 725  GKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHIC 784
              + +   + CVP   C CH++G  Y PG+      G C C +G + CD  A  +A   C
Sbjct: 827  DTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAA---C 883

Query: 785  PEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG--------- 835
            P G+ + +C     +L    ++ E TC    +N + +   PC+SGC C  G         
Sbjct: 884  PAGQVFVNCSDLHTDLE---LSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACF 940

Query: 836  ---------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLE 868
                                       VC+RG F CT +PC + CT YGDRHY +FDGL 
Sbjct: 941  LPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLP 1000

Query: 869  YDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQ 928
            +D++  C+V L+KS  D   SVI +N  C+ + ++C K + I+VG++ I  +D       
Sbjct: 1001 FDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSP 1060

Query: 929  SGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDK 988
              F L++K     W+ G++ +V+FP++ IT+LWD++TT+H++ GPQW+ +L+GLCGNFD 
Sbjct: 1061 ESF-LDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDL 1119

Query: 989  CTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDI 1048
             T N+M T  NLE+ N + FG SWA  +C    +    C  +  + P+AKKECSIL S++
Sbjct: 1120 KTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEV 1179

Query: 1049 FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            F  C  V+DVT F  NC  DTC C+ GGDCEC C S++AYA++CCQ G+++ WR+  +C 
Sbjct: 1180 FEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCP 1239

Query: 1109 LDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFK 1168
             DC+++N+ LG+GPY L+S    G ++G       +  +    V  +    F++T  L+K
Sbjct: 1240 YDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYK 1299

Query: 1169 EKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAF 1228
             K     +VSLE+A+RPN+FL+V  N +L L  W+    F + A+F  H+G    G  A 
Sbjct: 1300 AKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVAL 1359

Query: 1229 ELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPC 1288
            E  +K   F+  + + +    Y+ +E F+  + F + + + +     +CEWRY+ CA+PC
Sbjct: 1360 ESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPC 1419

Query: 1289 FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV---IPTEP---TL 1342
            F+TC DP A +C+ +P    C+P CP   +LDEVT +CVY  DC+     +PTE      
Sbjct: 1420 FQTCRDPRAASCRDVPRGRSCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNET 1479

Query: 1343 MPPAK 1347
            +PP++
Sbjct: 1480 LPPSQ 1484



 Score =  742 bits (1916), Expect = 0.0
 Identities = 361/923 (39%), Positives = 506/923 (54%), Gaps = 20/923 (2%)

Query: 1337 PTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLN 1396
            P +     P+  + P  ++ E +  +  T  +  T TT +    Q      DC ++ICL 
Sbjct: 2013 PVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQ------DCVRHICLE 2066

Query: 1397 MEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNN 1456
             +    N S +CP+    P CG  G  V+V  D CCP WEC CRCS+  +LS +TFDG++
Sbjct: 2067 GQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSH 2126

Query: 1457 AALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR 1516
             AL+  A YIL + P E++  H+  C             C   LN+T   H++ ++R  R
Sbjct: 2127 VALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNR 2186

Query: 1517 KVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYT 1576
            KV VD   V  P S     IED+G MY+I TP+ + I+W H +G++ +          + 
Sbjct: 2187 KVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGH- 2245

Query: 1577 EGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR--NCTEHDC 1634
             GLCGIC+ D  +DL +++G+++   ED   F++SW++  S     +   R  +C   DC
Sbjct: 2246 -GLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDC 2304

Query: 1635 SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWR 1694
            S C+ +++ R F  CH  V PE FCE +WI  T +    C AL+ YVA+C+KF +CI+WR
Sbjct: 2305 SPCLRMVSNRTFSACHRFVPPESFCE-LWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWR 2363

Query: 1695 TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS---CLNLREDCVCKVGTILHRPH 1751
              DYC   C     YQ CV  CE          G      C  L E CVC  GTILHR H
Sbjct: 2364 RSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRH 2423

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
            SA CIPE +CACTDS   PR  GE WN  +  C  ++C    +I+P++  C       C 
Sbjct: 2424 SALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCL 2483

Query: 1812 REAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDP 1871
            R  EV + +  K  CC   VC C+ TLCE   PTC    +L+      SCCP Y CECDP
Sbjct: 2484 RFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDP 2543

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
              C +   P CR+DQ +I  R  + CC S FC C  C   +P C +GE LTV  N+T  C
Sbjct: 2544 DLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELC 2603

Query: 1932 CPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTA 1991
            CP Y CVCE   CP   + C     LV+     +CCP   CEC+C+ + +P C + E + 
Sbjct: 2604 CPLYQCVCENFRCPQ--VQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQ 2661

Query: 1992 ID----HNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDN 2047
            +D    H+ ++ CGC +Y C K  VC+ +E+ V+ PGQ++++   +  C+T  C    D 
Sbjct: 2662 LDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDP 2721

Query: 2048 HTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTW 2107
             T F+ +N T V C   C+ +Q Y        CCG+C+NVSC F   NGT+ ++  G++W
Sbjct: 2722 LTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW 2781

Query: 2108 HYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQK 2167
              +C  + C  T  GA+++   + CPP NETEC    G V    EGCC+ CK + R C+K
Sbjct: 2782 IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKK 2841

Query: 2168 VIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLY 2227
            V I+  IRK +C S +P+N+ SCDG+CPSA+IYN NI ++ RFCKCCRE G++  SV L+
Sbjct: 2842 VTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLF 2901

Query: 2228 CSGNGTEIMYTLQEPIDCTCQWN 2250
            C+ N T + YT+QEP DC CQW+
Sbjct: 2902 CATNATWVPYTVQEPTDCACQWS 2924



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 123/516 (23%), Positives = 187/516 (36%), Gaps = 105/516 (20%)

Query: 382  ENCP-------CGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTT 434
            ++CP       CG  GLA              V VGG   C   +C  +CS+  D  F T
Sbjct: 2076 QHCPQGAAPPRCGILGLA--------------VRVGGDRCCPLWECACRCSIFPDLSFVT 2121

Query: 435  FDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQ-NLGLV-----CLQSITL------ 482
            FDG H +      YIL +   +    +T+    C+  NLG +     CL  + +      
Sbjct: 2122 FDGSHVALFKEAIYILSQSPDE---MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQ 2178

Query: 483  ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER 542
            +  D FN++VT+            GF       I+    ++++L T   ++I +      
Sbjct: 2179 VTIDRFNRKVTVDLQPVWPPVSRYGF------RIEDTGHMYMIL-TPSDIQIQWLHSSGL 2231

Query: 543  IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG---TPQLHANAWRVSS------- 592
            + ++ +   K +  GLCG  +G+  +D     G + G    P    ++W+V S       
Sbjct: 2232 MIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQ 2291

Query: 593  TCFAPVHVPVVD--PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKC 650
            T F P      D  PC              ++    F+ CH ++ P  + +L   D    
Sbjct: 2292 TRFRPDSCATTDCSPC------------LRMVSNRTFSACHRFVPPESFCELWIRDTKYV 2339

Query: 651  GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHC------SSFCLHSCI 704
               C+  AL  Y  +C +  V I++R +  +C  +C     Y  C         C    +
Sbjct: 2340 QQPCV--ALTVYVAMCHKFHVCIEWR-RSDYCPFLCSSDSTYQACVTACEPPKTCQDGIL 2396

Query: 705  SLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT-PSGL 762
                PE C     EGC C EG   +      C+P   C C    S+  P  L  T  S L
Sbjct: 2397 GPLDPEHC-QVLGEGCVCSEGTILHRRHSALCIPEAKCAC--TDSMGVPRALGETWNSSL 2453

Query: 763  CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPE--LPAGGVNC--------ETTCA 812
              C     +  +   P  +  CP  +     RF +    LP     C        +T C 
Sbjct: 2454 SGCCQHQCQAPDTIVPVDLG-CPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCE 2512

Query: 813  NLAMNFTCTP----------SSPCIS-GCVCAPGVC 837
             LA   TC P           S C S  C C P +C
Sbjct: 2513 GLAP--TCRPGHRLLTHFQEDSCCPSYSCECDPDLC 2546



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/510 (20%), Positives = 172/510 (33%), Gaps = 117/510 (22%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTE- 1339
            Y  C   C  +C    +     +  V+GC  YCP  +I ++    CV P +C    P E 
Sbjct: 426  YNECIACCPASCHPRASCVDSEIACVDGC--YCPNGLIFEDGG--CVAPAEC----PCEF 477

Query: 1340 -PTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNME 1398
              TL PP                                          DC+   C + +
Sbjct: 478  HGTLYPPGSVVKE------------------------------------DCNTCTCTSGK 501

Query: 1399 WQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAA 1458
            W+                               C    CP  CS+  ++   TFDG    
Sbjct: 502  WE-------------------------------CSTAVCPAECSVTGDIHFTTFDGRRYT 530

Query: 1459 LYSMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTT---PIHKIIVN 1512
              +   YIL +        +      C +NQ       G C + ++V     P  ++ + 
Sbjct: 531  FPATCQYILAKSRSSGTFTVTLQNAPCGLNQ------DGACVQSVSVILHQDPRRQVTLT 584

Query: 1513 RLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +    +  D   +  P++     I    S+++ + T  G+ + +      + +    R+ 
Sbjct: 585  QAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRW- 643

Query: 1572 LSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWE-IEKSFEVTMRRPVRNCT 1630
                T GLCG  N +  DD     G   +  +   LF  SW+ +     +    P+  C 
Sbjct: 644  -VEDTVGLCGTFNGNTQDDFLSPVGVPESTPQ---LFGNSWKTLSACSPLVSGSPLDPCD 699

Query: 1631 EHDCS-----QCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWN-YECDALSAYVALC 1684
             H  +     Q   +L   +F PC   +SP  + E+   +         C  L+ Y  LC
Sbjct: 700  VHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLC 759

Query: 1685 NKFDICIQWRTP-DYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC----------L 1733
             +  + + +R     C+LSC   KEY PCV PC  RTC  Q      +C           
Sbjct: 760  RRHGLPVDFRARLPACALSCEASKEYSPCVAPC-GRTC--QDLASPEACGVDGGDDLSRD 816

Query: 1734 NLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               E C C   T L    +  C+P  +C+C
Sbjct: 817  ECVEGCACPPDTYLD-TQADLCVPRNQCSC 845



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 92/363 (25%), Positives = 135/363 (37%), Gaps = 64/363 (17%)

Query: 1433 PEWECPCRCSMLSELSIITFDGNNAALYSMASYILV---RIPGE---IIVAHIEKCSMNQ 1486
            PE +  CR     +  + TFDG    L    SY LV      G+   I V +  +C  + 
Sbjct: 145  PERDSICRA--WGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSP 202

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT 1546
                R   L F        IH      LA++V    + V LP       ++      ++ 
Sbjct: 203  YTCSRAVSLFFVG---EQEIH------LAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVR 253

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
              +   + W    G   ++      L  +T GLCG  N DP DDL   +G +    +D+ 
Sbjct: 254  HQSAFTLAWD---GASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKL---TDDVV 307

Query: 1607 LFIESWEIEKSFE----VTMRRPVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSP 1655
             F+ SW+ +   +     T   P   C + +         QC  LL R  F  CH  VSP
Sbjct: 308  EFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALL-RPPFDACHAYVSP 366

Query: 1656 --------EDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQ-WRTP-DYCSLSCPE 1705
                     D C+ M    T+     C AL+ Y   C +    +Q WRT    C++ C E
Sbjct: 367  LPFTASCTSDLCQSMGDVATW-----CRALAEYARACAQAGRPLQGWRTQLRQCTVHCKE 421

Query: 1706 -GKEYQPCVRPCEARTCLNQWFYGHTSCLNLR----EDCVCKVGTILHRPHSAQCIPEKE 1760
                Y  C+  C A +C     +   SC++      + C C  G I        C+   E
Sbjct: 422  KAFTYNECIACCPA-SC-----HPRASCVDSEIACVDGCYCPNGLIF---EDGGCVAPAE 472

Query: 1761 CAC 1763
            C C
Sbjct: 473  CPC 475



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 84/396 (21%), Positives = 137/396 (34%), Gaps = 66/396 (16%)

Query: 18   PSGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDG 77
            P G+ P  C       + G   C        RC I P++               F TFDG
Sbjct: 2079 PQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLS--------------FVTFDG 2124

Query: 78   IYYYFPGNCSYIFAK-----------DCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFF 126
             +        YI ++           DC      +  W    P CL  +   +       
Sbjct: 2125 SHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNW---PPFCLVMLNMTH------L 2175

Query: 127  SNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYL-K 185
            ++Q  I  +  ++  +   +  P +     IE      ++ T     + W   SG+ + +
Sbjct: 2176 AHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVE 2235

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT---EDIAMFANSWSVQTPDDTKCVLTPS 242
             S+  K +  GLCG  +   ++D  +         ED A F +SW  Q P     V    
Sbjct: 2236 ASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW--QVPSSLTSVGQTR 2293

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF----PFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
              P+ C++           C   L+      F +CH ++ P  +    + D   T   + 
Sbjct: 2294 FRPDSCATT---------DCSPCLRMVSNRTFSACHRFVPPESFCELWIRD---TKYVQQ 2341

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG-- 356
             C A T Y   C      I+  R D+  C   C     ++ C++ C P  T +   LG  
Sbjct: 2342 PCVALTVYVAMCHKFHVCIEWRRSDY--CPFLCSSDSTYQACVTACEPPKTCQDGILGPL 2399

Query: 357  SNLHCL---DGCYCPDGLVM---DNGTCISLENCPC 386
               HC    +GC C +G ++    +  CI    C C
Sbjct: 2400 DPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCAC 2435



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 27/283 (9%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            C  + C   C+I+ D  + +FDG       +    L +S D+     +   K      + 
Sbjct: 2102 CPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLN 2161

Query: 904  CSKSVLISVGDTEIYLNDT--PYKQK-----QSGFFLENKSTYQLWKAGYYIVVYFPEKD 956
                 L+ +  T +    T   + +K     Q  +   ++  +++   G+  ++  P  D
Sbjct: 2162 WPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPS-D 2220

Query: 957  ITILWDRKTTIHI-KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR---VFGDSW 1012
            I I W   + + I +     K +  GLCG  D   +ND+T  +   V  A     F DSW
Sbjct: 2221 IQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSW 2280

Query: 1013 ALGQCESPDETIKPCEAHQNKFPYAKKECS----ILYSDIFASCRNVIDVTSFAKNCHED 1068
                 + P       +        A  +CS    ++ +  F++C   +   SF +    D
Sbjct: 2281 -----QVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRD 2335

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            T         +  C ++  Y   C +  + I WR S  C   C
Sbjct: 2336 T------KYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLC 2372



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/480 (20%), Positives = 164/480 (34%), Gaps = 79/480 (16%)

Query: 1281 YEPCATPCFKTCSD---PEALACKFLPP------VEGCLPYCPKNMILDEVTLKCVYPRD 1331
            Y PC  PC +TC D   PEA              VEGC   CP +  LD     CV    
Sbjct: 785  YSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCA--CPPDTYLDTQADLCVPRNQ 842

Query: 1332 CIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQ 1391
            C      +    PP    +P  ++        +   D   P        Q F    D   
Sbjct: 843  CS--CHFQGVDYPPGDSDIP--SLGHCHCKDGVMSCDSRAPAAACPAG-QVFVNCSDLHT 897

Query: 1392 YICLNME----WQLYNWSLN----------CPKDV----------EMPDCGFRGRPVQVN 1427
             + L+ E     QL N S++          CP+ +          E   C ++G+     
Sbjct: 898  DLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPG 957

Query: 1428 SDICCPEWECPCR--------------CSMLSELSIITFDGNNAALYSMASYILVRIPGE 1473
              +  P   C C+              C+   +    TFDG            LV+   +
Sbjct: 958  DQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSD 1017

Query: 1474 IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE 1533
            +  + I + ++N   SG I   C K +++      I+ +  +     +S +       QE
Sbjct: 1018 VSFSVIVE-NVNCYSSGMI---CRKFISINVGNSLIVFDDDSGNPSPESFLD----DKQE 1069

Query: 1534 LSIEDSGSMYVITTPAGLI-IKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLR 1592
            +     G   ++  P   I + W   T    +H            GLCG  +    +++R
Sbjct: 1070 VHTWRVGFFTLVHFPQEHITLLWDQRT---TVHVQAGPQWQGQLAGLCGNFDLKTINEMR 1126

Query: 1593 MQNGTIITNMEDIGLFIESWEIEKSFE---VTMRRPVRN-CTEHDCSQCIDLLNRRIFIP 1648
                  +TN ++ G    + E   + +   + +  P+R    + +CS    +L   +F  
Sbjct: 1127 TPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECS----ILLSEVFEI 1182

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCNKFDICIQWRTPDYCSLSC 1703
            CH  V    F   C       +   + EC   ++SAY   C +  + + WRTP  C   C
Sbjct: 1183 CHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDC 1242


>gi|169202626 PREDICTED: similar to mucin 5, partial [Homo sapiens]
          Length = 2013

 Score =  597 bits (1540), Expect = e-170
 Identities = 363/1135 (31%), Positives = 549/1135 (48%), Gaps = 102/1135 (8%)

Query: 58   NGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYS 117
            NGR  +C TWG +H++TFDG  + FPG C+Y+F++ CG     + + +  S +      S
Sbjct: 77   NGR--VCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPTLS 134

Query: 118  CYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWD 177
                  L   +   I++    +  NG  + LP +   + I++ + Y  V+   G  L W+
Sbjct: 135  RV----LMKVDGVVIQLTKGSVLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGLVLMWN 190

Query: 178  GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKC 237
                + L+L   +  K+CGLCG++N +     ++        +  F N   +  P + +C
Sbjct: 191  HDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDPTE-QC 248

Query: 238  VLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLS-CHEYIDPYLYIASCVNDLCKTDDD 296
                 + P  CS+G       F  C+ LL     S C   +D   Y+ +C  DLC  +D 
Sbjct: 249  QDPVPEPPRNCSTG-------FGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDT 301

Query: 297  ETY---CRAATEYARACSHAGYPIQDWRD-DFPACTDKCDDSFVHRDCISCCPPTCTFEK 352
            +     C    EY+R C+HAG   QDWR  DF  C  KC ++  + +C S C  TC+ ++
Sbjct: 302  DLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDF--CPQKCPNNMQYHECRSPCADTCSNQE 359

Query: 353  QCLGSNLHCLDGCYCPDGLVMDN---GTCISLENCPCGFHGLAYSVGSKIEQECTECVCV 409
                   HC+ GC+CP+G V+D+     C+ +  C C ++G AY+ G+    +CT C C 
Sbjct: 360  HSRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAPGATYSTDCTNCTCS 419

Query: 410  GGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCE 469
            GG W+C E  CP  CSV+G +HF+TFDG+ Y+  G C Y+L K      FT+  +   C 
Sbjct: 420  GGRWSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCG 479

Query: 470  QNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI----VEIQTLSSLFIL 525
                  CL+S+TL L D     V +   G++    NQ +    I    V I   S+ FI+
Sbjct: 480  LTDSETCLKSVTLSL-DGVQTVVVIKASGEVFL--NQIYTQLPISAANVTIFRPSTFFII 536

Query: 526  LKTTFGLKI-LFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLH 584
             +T+ GL++ L  +   ++++QL    + +T GLCG FN    DDF + SG++E T    
Sbjct: 537  AQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGVVEATAAAF 596

Query: 585  ANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQE--LFAPCHIYISPGLYYQ 641
             N ++  + C   +     DPC+++ +N  YA H C  +      F  CH  + PG YY 
Sbjct: 597  FNTFKTQAAC-PNIRNSFEDPCSLSVENEKYAQHWCSQLTDADGPFGRCHAAVKPGTYYS 655

Query: 642  LCRHDACKCGSS--CLCNALAHYAYLCGQHGVPIDFRTQISFCA---VVCQKGMLYHHCS 696
             C  D C C  S  CLC AL+ Y + C   GV +    +   C      C K M YH+  
Sbjct: 656  NCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLG-GWRDGVCTKPMTTCPKSMTYHYHV 714

Query: 697  SFCLHSCISLSSPE-QCSDDC--AEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPG 753
            S C  +C SLS  +  CS      +GC CP+G F +DT   CV   +C C++RGS+   G
Sbjct: 715  STCQPTCRSLSEGDITCSVGFIPVDGCICPKGTFLDDT-GKCVQASNCPCYHRGSMIPNG 773

Query: 754  ELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCAN 813
            E +     +C C++G + C     P+ V  C     +FDCR   P     G  C+ +C  
Sbjct: 774  ESVHDSGAICTCTHGKLSCIGGQAPAPV--CAAPMVFFDCRNATPG--DTGAGCQKSCHT 829

Query: 814  LAMNFTCTPSSPCISGCVCAPGV------------------------------------- 836
            L M  TC  S  C+ GCVC  G+                                     
Sbjct: 830  LDM--TCY-SPQCVPGCVCPDGLVADGEGGCITAEDCPCVHNEASYRAGQTIRVGCNTCT 886

Query: 837  CRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLI------KSADDSDISV 890
            C   M+ CT  PC A C +YGD HY +FDG  Y +  DC+  L+      K +      V
Sbjct: 887  CDSRMWRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGKDSTQDSFRV 946

Query: 891  IAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVV 950
            + +N  C      CSK++ I +G  E+ L+    K +  G     +  Y + + G Y+VV
Sbjct: 947  VTENVPCGTTGTTCSKAIKIFLGGFELKLSHG--KVEVIGTDESQEVPYTIRQMGIYLVV 1004

Query: 951  YFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGD 1010
               +  + +LWD+KT+I I + P++K ++ GLCGNFD    ND  T +   V +   FG+
Sbjct: 1005 D-TDIGLVLLWDKKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRSRSVVGDVLEFGN 1063

Query: 1011 SWALG-QCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDT 1069
            SW L   C        PC A+  +  +A+K+CSIL+   FA+C   ++   + + C  D 
Sbjct: 1064 SWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACHAHVEPARYYEACVNDA 1123

Query: 1070 CNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN-EGLGEGPY 1123
            C C+ GGDCEC CT++AAYA  C + G+ + WR+ ++C L C+YYN EG  E  Y
Sbjct: 1124 CACDSGGDCECFCTAVAAYAQACHEVGLCVSWRTPSICPLFCDYYNPEGQCEWHY 1178



 Score =  228 bits (580), Expect = 7e-59
 Identities = 148/461 (32%), Positives = 218/461 (47%), Gaps = 47/461 (10%)

Query: 344  CPPTC-TFEKQCLGSNLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQ 401
            C  +C T +  C      C+ GC CPDGLV D  G CI+ E+CPC  +  +Y  G  I  
Sbjct: 823  CQKSCHTLDMTCYSPQ--CVPGCVCPDGLVADGEGGCITAEDCPCVHNEASYRAGQTIRV 880

Query: 402  ECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV------KGTG 455
             C  C C   +W CT+  C   C+V GD H+ TFDG+ YSF G C+Y LV      K + 
Sbjct: 881  GCNTCTCDSRMWRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGKDST 940

Query: 456  KDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVE 515
            +D F +  +  PC    G  C ++I + L   F  +++ G+   I T  +Q         
Sbjct: 941  QDSFRVVTENVPCGTT-GTTCSKAIKIFL-GGFELKLSHGKVEVIGTDESQEVPYT---- 994

Query: 516  IQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSG 575
            I+ +  +++++ T  GL +L+      I+I L+  +K R  GLCG F+    +DF + S 
Sbjct: 995  IRQMG-IYLVVDTDIGLVLLWD-KKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRSR 1052

Query: 576  MIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAA-HCDVIHQELFAPCHIYI 634
             + G      N+W++S +C  P  +   DPC  N     +A   C ++H   FA CH ++
Sbjct: 1053 SVVGDVLEFGNSWKLSPSC--PDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACHAHV 1110

Query: 635  SPGLYYQLCRHDACKCGSS----CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC---- 686
             P  YY+ C +DAC C S     C C A+A YA  C + G+ + +RT  S C + C    
Sbjct: 1111 EPARYYEACVNDACACDSGGDCECFCTAVAAYAQACHEVGLCVSWRTP-SICPLFCDYYN 1169

Query: 687  ---QKGMLYHHCSSFCLHSCISLSSPEQCSDDC--AEGC--NCP-EGKFYEDTLNFCV-- 736
               Q    Y  C   CL +C +      C  D    EGC   CP E   +++    CV  
Sbjct: 1170 PEGQCEWHYQPCGVPCLRTCRNPRG--DCLRDVWGLEGCYPKCPPEAPIFDEDKMQCVAT 1227

Query: 737  ---PIFHCRCHYRGSVYQPGELIPTPSGL--CQCSNGTVKC 772
               P    RCH  G  Y+PG ++P+      C C+   V+C
Sbjct: 1228 CPTPPLPPRCHVHGKSYRPGAVVPSDKNCQSCLCTERGVEC 1268



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 122/499 (24%), Positives = 195/499 (39%), Gaps = 88/499 (17%)

Query: 1287 PCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCI-----PVIPTEPT 1341
            P  ++ S+ +        PV+GC+  CPK   LD+ T KCV   +C       +IP   +
Sbjct: 719  PTCRSLSEGDITCSVGFIPVDGCI--CPKGTFLDD-TGKCVQASNCPCYHRGSMIPNGES 775

Query: 1342 LMPPAKPTVPMFTVWEMI---TPSDITVFDML-------TP-TTGLECEPQKFDPVYDCS 1390
            +                I    P+ +    M+       TP  TG  C  QK     D +
Sbjct: 776  VHDSGAICTCTHGKLSCIGGQAPAPVCAAPMVFFDCRNATPGDTGAGC--QKSCHTLDMT 833

Query: 1391 QYI------CLNMEWQLYNWSLNCPKDVEMP----DCGFR-GRPVQVNSDICCPE---WE 1436
             Y       C+  +  + +    C    + P    +  +R G+ ++V  + C  +   W 
Sbjct: 834  CYSPQCVPGCVCPDGLVADGEGGCITAEDCPCVHNEASYRAGQTIRVGCNTCTCDSRMWR 893

Query: 1437 C---PC--RCSMLSELSIITFDGNNAALYSMASYILVR--IPGEIIVAHIEKCSMNQAPS 1489
            C   PC   C++  +   +TFDG + +      Y LV+    G+       +      P 
Sbjct: 894  CTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGKDSTQDSFRVVTENVPC 953

Query: 1490 GRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQEL--SIEDSGSMYVITT 1547
            G     C K +       KI +     K+    + V     SQE+  +I   G   V+ T
Sbjct: 954  GTTGTTCSKAI-------KIFLGGFELKLSHGKVEVIGTDESQEVPYTIRQMGIYLVVDT 1006

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEG-LCGICNEDPD---DDLRMQNGTIITNME 1603
              GL++ W   T I         NLS   +G +CG+C    D   +D   ++ +++ ++ 
Sbjct: 1007 DIGLVLLWDKKTSIF-------INLSPEFKGRVCGLCGNFDDIAVNDFATRSRSVVGDVL 1059

Query: 1604 DIGLFIESWEIEKSFEVTMRRPVRNCTEHDC------SQCIDLLNRRIFIPCHDKVSPED 1657
            + G    SW++  S    +  P   CT +         QC  +L+   F  CH  V P  
Sbjct: 1060 EFG---NSWKLSPSCPDALA-PKDPCTANPFRKSWAQKQC-SILHGPTFAACHAHVEPAR 1114

Query: 1658 FCEKMWINYTYFWNYE------CDALSAYVALCNKFDICIQWRTPDYCSLSC----PEGK 1707
            + E   +N     +        C A++AY   C++  +C+ WRTP  C L C    PEG+
Sbjct: 1115 YYEAC-VNDACACDSGGDCECFCTAVAAYAQACHEVGLCVSWRTPSICPLFCDYYNPEGQ 1173

Query: 1708 ---EYQPCVRPCEARTCLN 1723
                YQPC  PC  RTC N
Sbjct: 1174 CEWHYQPCGVPC-LRTCRN 1191



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 99/436 (22%), Positives = 158/436 (36%), Gaps = 48/436 (11%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPG---EIIVAHIEKCSMNQAPSGRISGLCF 1497
            CS        TFDG+      + +Y+     G   E     + +   + AP+  +S +  
Sbjct: 81   CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPT--LSRVLM 138

Query: 1498 KKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSH 1557
            K       +  +++      V V+   V LPFS   + I+ S S   +    GL++ W+H
Sbjct: 139  K-------VDGVVIQLTKGSVLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGLVLMWNH 191

Query: 1558 LTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKS 1617
               ++          ++ T GLCG  N  P     + + T +T ME  G   +  +  + 
Sbjct: 192  DDSLL---LELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDPTEQ 247

Query: 1618 FEVTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKM-----WINYTYFWNY 1672
             +  +  P RNC+      C +LL+ ++F  C   V    + E       +   T   + 
Sbjct: 248  CQDPVPEPPRNCST-GFGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDLLSC 306

Query: 1673 ECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS 1731
             C  L+ Y   C       Q WR PD+C   CP   +Y  C  PC A TC NQ  +    
Sbjct: 307  VCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPC-ADTCSNQ-EHSRAC 364

Query: 1732 CLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTL----Y 1787
              +    C C  GT+L       C+P  +CAC          G  ++     CT     +
Sbjct: 365  EDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACV-YNGAAYAPGATYSTDCTNCTCSGGRW 423

Query: 1788 KCLE------------------NGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSK 1829
             C E                  +G    +  DC    T  C+  A  V+  + +      
Sbjct: 424  SCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCGLTDS 483

Query: 1830 EVCGCDTTLCETSIPT 1845
            E C    TL    + T
Sbjct: 484  ETCLKSVTLSLDGVQT 499



 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 123/527 (23%), Positives = 187/527 (35%), Gaps = 58/527 (11%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVR---IPGEIIVAHIEKCSMNQAP 1488
            C E  CP  CS+L      TFDG    ++   SY+L +        ++A + +C +    
Sbjct: 425  CQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCGLTD-- 482

Query: 1489 SGRISGLCFKKLNVTTP-IHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT- 1546
                S  C K + ++   +  ++V + + +V ++ I   LP S+  ++I    + ++I  
Sbjct: 483  ----SETCLKSVTLSLDGVQTVVVIKASGEVFLNQIYTQLPISAANVTIFRPSTFFIIAQ 538

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
            T  GL +    L   + +       L   T GLCG  N    DD R  +G +        
Sbjct: 539  TSLGLQLN-LQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGVVEAT---AA 594

Query: 1607 LFIESWE-------IEKSFEVTMRRPVRN--CTEHDCSQCIDLLNRRIFIPCHDKVSPED 1657
             F  +++       I  SFE      V N    +H CSQ  D      F  CH  V P  
Sbjct: 595  AFFNTFKTQAACPNIRNSFEDPCSLSVENEKYAQHWCSQLTDADGP--FGRCHAAVKPGT 652

Query: 1658 F---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCS---LSCPEGKEYQP 1711
            +   C     N     +  C ALS+YV  C    + +       C+    +CP+   Y  
Sbjct: 653  YYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWRDGVCTKPMTTCPKSMTYHY 712

Query: 1712 CVRPCEARTCLNQWFYGHTSC---LNLREDCVCKVGTILHRPHSAQCIPEKECACTDSED 1768
             V  C+  TC      G  +C       + C+C  GT L    + +C+    C C     
Sbjct: 713  HVSTCQP-TC-RSLSEGDITCSVGFIPVDGCICPKGTFL--DDTGKCVQASNCPCYHRGS 768

Query: 1769 Q-PRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCC 1827
              P       +G I  CT  K    G          + P PVC       M   D     
Sbjct: 769  MIPNGESVHDSGAICTCTHGKLSCIGG---------QAPAPVC----AAPMVFFDCRNAT 815

Query: 1828 SKEV-CGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDPLK-CPSISTPECRED 1885
              +   GC  + C T   TC + Q +     P       +  C   + CP +        
Sbjct: 816  PGDTGAGCQKS-CHTLDMTCYSPQCVPGCVCPDGLVADGEGGCITAEDCPCVHNEASYRA 874

Query: 1886 QFMIQVRQEEPCCFSPF--CVCESCTKPVPLCHDGEFLTVDLNSTHF 1930
               I+V      C S    C  + C     +  DG +LT D  S  F
Sbjct: 875  GQTIRVGCNTCTCDSRMWRCTDDPCLATCAVYGDGHYLTFDGQSYSF 921



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 9/103 (8%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDCIPV 1335
            CEW Y+PC  PC +TC +P     + +  +EGC P CP    I DE  ++CV      P 
Sbjct: 1174 CEWHYQPCGVPCLRTCRNPRGDCLRDVWGLEGCYPKCPPEAPIFDEDKMQCV---ATCPT 1230

Query: 1336 IPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLEC 1378
             P  P      K   P       + PSD      L    G+EC
Sbjct: 1231 PPLPPRCHVHGKSYRP-----GAVVPSDKNCQSCLCTERGVEC 1268



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 9/57 (15%)

Query: 1280 RYEPCATPCFKTCSDPE-ALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV 1335
            +Y  C +PC  TCS+ E + AC+    V GC  +CP+  +LD++         C+PV
Sbjct: 343  QYHECRSPCADTCSNQEHSRACED-HCVAGC--FCPEGTVLDDIG-----QTGCVPV 391


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score =  578 bits (1489), Expect = e-164
 Identities = 356/1136 (31%), Positives = 537/1136 (47%), Gaps = 106/1136 (9%)

Query: 57   GNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVY 116
            G      C  +G     TFDG  Y F G CSY+ A  C             S   +G   
Sbjct: 28   GRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQK----------RSFSIIGDFQ 77

Query: 117  SCYR-SISLFFSNQEEIRIYGHEIKKNGIS-LTLPQTIGQIFIEKLADYI-LVKTTFGFS 173
            +  R S+S++     +I ++ +     G   +++P     +++E  A Y  L    +GF 
Sbjct: 78   NGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFV 137

Query: 174  LAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
               DG     + LS+ +  K+CGLCGN+N    DDF+  +   T D   FANSW++ + +
Sbjct: 138  ARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGE 197

Query: 234  D-TKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFP-FLSCHEYIDPYLYIASCVNDLC 291
               +    PS   N  S  M   + ++ +CQ+L     F  CH  +DP  ++A C   LC
Sbjct: 198  QWCERASPPSSSCNISSGEMQ--KGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLC 255

Query: 292  KTDDD-ETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCT- 349
            +     E  C A  EYAR C+  G  +  W D   AC+  C     +R C+S C  TC  
Sbjct: 256  ECAGGLECACPALLEYARTCAQEGMVLYGWTDH-SACSPVCPAGMEYRQCVSPCARTCQS 314

Query: 350  --FEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECV 407
                + C      C+DGC CP+G ++D G C+    CPC   G  Y  G+ + ++C  C+
Sbjct: 315  LHINEMC---QERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCI 371

Query: 408  CVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAP 467
            C    W C+ ++CP +C V G SHF +FD R+++F G+CQY+L +      F+I ++   
Sbjct: 372  CRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQ 431

Query: 468  CEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPN--QGFNLNGIVEIQTLSSLFIL 525
            C  +   VC +S+T+ L    N  V L  G  +       Q   L G + IQ   +  + 
Sbjct: 432  CADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVR 491

Query: 526  LKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLH 584
            L  ++G  +    DG  R+ ++L+  +  +T GLCG +NGN  DDFL+PSG+ E   +  
Sbjct: 492  L--SYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDF 549

Query: 585  ANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQELFAPCHIYISPGLYYQLC 643
             NAW++   C   +     DPC +N +   ++   C V+    F  CH  +SP  Y + C
Sbjct: 550  GNAWKLHGDC-QDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNC 608

Query: 644  RHDACKC--GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLH 701
            R+D C C  G  CLC ALA YA  C   GV + +R +   C + C KG +Y  C + C  
Sbjct: 609  RYDVCSCSDGRECLCGALASYAAACAGRGVRVAWR-EPGRCELNCPKGQVYLQCGTPCNL 667

Query: 702  SCISLSSP-EQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPS 760
            +C SLS P E+C++ C EGC CP G  Y D    CVP   C C+Y G ++QP ++     
Sbjct: 668  TCRSLSYPDEECNEACLEGCFCPPG-LYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHH 726

Query: 761  GLCQCSNGTVKCDELATPSAV--------HICPEGKEYFDCR-------FPDPELPAGGV 805
             +C C +G + C     P ++         +    K    CR        P   L A G+
Sbjct: 727  TMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGL 786

Query: 806  NCETTCANLAMNFTCTPSSPCISGCVCAPG------------------------------ 835
             C  TC N  +      S  C+SGC+C PG                              
Sbjct: 787  ECTKTCQNYDLECM---SMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVK 843

Query: 836  ------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKS---ADDS 886
                  VCR   +NCT + C A C+  G  HY +FDGL+Y +  +CQ  L++    ++  
Sbjct: 844  IGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPG 903

Query: 887  DISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGY 946
               ++  NK C    + C K V I V   EI L D     K+    +++++ +++ ++G 
Sbjct: 904  TFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRP---MKDETHFEVVESGR 960

Query: 947  YIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR 1006
            YI++    K ++++WDR  +I + +   ++ K+ GLCGNFD   +ND+T+SN L+V    
Sbjct: 961  YIILLLG-KALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSN-LQVEEDP 1018

Query: 1007 V-FGDSWALG-QCESPDET---IKPCEAHQN--KFPYAKKECSILYSDIFASCRNVIDVT 1059
            V FG+SW +  QC    +      P   H N  K       C IL SD+F  C  ++D  
Sbjct: 1019 VDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPE 1078

Query: 1060 SFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
             +   C  DTC+C   GDC C C +IAAYA+ C Q G  + WR++T+C   CE  N
Sbjct: 1079 PYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERN 1134



 Score =  217 bits (553), Expect = 9e-56
 Identities = 217/952 (22%), Positives = 357/952 (37%), Gaps = 172/952 (18%)

Query: 1406 LNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASY 1465
            +NC + +  P C     PV+V     C  W CPC C+  S   I+TFDG N  L    SY
Sbjct: 1917 VNCDRGLR-PSCPNSQSPVKVEETCGC-RWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSY 1974

Query: 1466 ILVRIPGEI--IVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSI 1523
            +L +   +   ++ H   CS   A  G +  +  K   ++  +H  +      +V V+  
Sbjct: 1975 VLFQNKEQDLEVILHNGACSPG-ARQGCMKSIEVKHSALSVELHSDM------EVTVNGR 2027

Query: 1524 VVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDI---HFGFRFNLS-----SY 1575
            +V +P+    + +   G++          ++++HL  I      +  F+  LS     S 
Sbjct: 2028 LVSVPYVGGNMEVNVYGAIMHE-------VRFNHLGHIFTFTPQNNEFQLQLSPKTFASK 2080

Query: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635
            T GLCGIC+E+  +D  +++GT+ T+ + +   ++ W +++  +         C   D S
Sbjct: 2081 TYGLCGICDENGANDFMLRDGTVTTDWKTL---VQEWTVQRPGQTCQPILEEQCLVPDSS 2137

Query: 1636 QCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQ 1692
             C  LL   +F  CH  ++P  F   C++   +        C+ +++Y  LC    +C+ 
Sbjct: 2138 HCQVLL-LPLFAECHKVLAPATFYAICQQDSCHQEQV----CEVIASYAHLCRTNGVCVD 2192

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYG-HTSCLNLREDCVCKVGTILHRPH 1751
            WRTPD+C++SCP    Y  C   C      N    G H S     E C C    ++    
Sbjct: 2193 WRTPDFCAMSCPPSLVYNHCEHGCPRHCDGNVSSCGDHPS-----EGCFCPPDKVMLE-- 2245

Query: 1752 SAQCIPEKECA-CTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVC 1810
               C+PE+ C  C   +       E W      C +  CL    +      C     P C
Sbjct: 2246 -GSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTC 2304

Query: 1811 EREAEVVMGIIDKWTCCSKEVCGCDTTLCETS-IPTCTNSQKLIVGH------------- 1856
                EV     +   CC +  C CD   C+   +P C    +  + +             
Sbjct: 2305 GL-CEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACR 2363

Query: 1857 -------SPLSC-------------CPQYKCECD----PLKCP------------SISTP 1880
                   SP SC             C +Y+C C+     + CP              +T 
Sbjct: 2364 KEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPLGYLASTATNDCGCTTT 2423

Query: 1881 ECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYCV-- 1938
             C  D+  +      P        C+ CT     C D E   + L      C Q  C   
Sbjct: 2424 TCLPDKVCVHRSTIYPVGQFWEEGCDVCT-----CTDMEDAVMGLRVAQ--CSQKPCEDS 2476

Query: 1939 -----------------CEPNLCPMPLLNCAEDMNLVKENVSGQ-CCPTWHC---EC--- 1974
                             C P+ C +   +   D     ++V  Q   P   C   EC   
Sbjct: 2477 CRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRV 2536

Query: 1975 -----------NCENLVMPTCEVGEFTAIDHNFQSDCG----CIQYLCEKDDVCVFQEVS 2019
                       +C  L +P C  G        FQ  C     C    CE+ + C+    +
Sbjct: 2537 KEEVFIQQRNVSCPQLEVPVCPSG--------FQLSCKTSACCPSCRCERMEACMLNG-T 2587

Query: 2020 VLNPGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKK-CDVHQVYTPSPSDY 2078
            V+ PG++++     D C T  C+ +    +GF       + C K  C+   +     ++ 
Sbjct: 2588 VIGPGKTVMI----DVCTTCRCMVQVGVISGFK------LECRKTTCNPCPLGYKEENNT 2637

Query: 2079 G-CCGTCKNVSCKFHMENGTSVVYAVGSTWHYNCTTYECVKTDEGAIILNYTMV-CPPFN 2136
            G CCG C   +C   +  G  +      T    C T+ C   + G       +  CPPF+
Sbjct: 2638 GECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFD 2697

Query: 2137 ETECKMNEGIVKLYNEGCCKICKREERICQKVIIK-SVIRKQDCMSQSPINVASCDGKCP 2195
            E +C    G +      CC  C+  E  C  +  +   ++   C S+  +++  C GKC 
Sbjct: 2698 EHKCLAEGGKIMKIPGTCCDTCEEPE--CNDITARLQYVKVGSCKSEVEVDIHYCQGKCA 2755

Query: 2196 SATIYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTC 2247
            S  +Y+I+I      C CC       + V L+C+ NG+ + + +   ++C C
Sbjct: 2756 SKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCT-NGSVVYHEVLNAMECKC 2806



 Score =  213 bits (542), Expect = 2e-54
 Identities = 136/474 (28%), Positives = 220/474 (46%), Gaps = 46/474 (9%)

Query: 344  CPPTC-TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQE 402
            C  TC  ++ +C+  ++ C+ GC CP G+V     C++LE CPC   G  Y+ G  ++  
Sbjct: 788  CTKTCQNYDLECM--SMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIG 845

Query: 403  CTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK---GTGKDKF 459
            C  CVC    WNCT+  C   CS +G +H+ TFDG  Y F G CQY+LV+   G+    F
Sbjct: 846  CNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTF 905

Query: 460  TITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTL 519
             I +    C  +  + C + +T+++E     ++ L  G   +  P +      +VE    
Sbjct: 906  RILVGNKGC-SHPSVKCKKRVTILVE---GGEIELFDGEVNVKRPMKDETHFEVVE---- 957

Query: 520  SSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG 579
            S  +I+L     L +++      I + L   ++ +  GLCG F+G   +D  S +  +E 
Sbjct: 958  SGRYIILLLGKALSVVWD-RHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEE 1016

Query: 580  TPQLHANAWRVSSTCFAPVHVPV-VDPC----NINQQNIGYAAHCDVIHQELFAPCHIYI 634
             P    N+W+VSS C     VP+   P     NI +Q +   + C ++  ++F  C+  +
Sbjct: 1017 DPVDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTM-VDSSCRILTSDVFQDCNKLV 1075

Query: 635  SPGLYYQLCRHDACKCGS----SCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGM 690
             P  Y  +C +D C C S    +C C+ +A YA++C QHG  + +RT  + C   C++  
Sbjct: 1076 DPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRT-ATLCPQSCEERN 1134

Query: 691  L----------YHHCSSFCLHSCISLSSPEQCSDDCAEGC--NCPEGKFYEDTLNFCVPI 738
            L          Y+ C+  C  +C     P  C   C EGC  +CP GK  ++ L  CV  
Sbjct: 1135 LRENGYECEWRYNSCAPACQVTC-QHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDP 1193

Query: 739  FHCR-CHYRGSVYQPGELI------PTPSGLCQCSNGTVKCDELATPSAVHICP 785
              C  C   G  +  G+ +      P    +C C    + C+    P  + + P
Sbjct: 1194 EDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPP 1247



 Score =  134 bits (337), Expect = 1e-30
 Identities = 104/400 (26%), Positives = 168/400 (42%), Gaps = 52/400 (13%)

Query: 398  KIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKD 457
            K+E+ C      G  W C     P  C+     H  TFDG+++   G C Y+L +   +D
Sbjct: 1935 KVEETC------GCRWTC-----PCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQD 1983

Query: 458  KFTITLQKAPCEQNLGLVCLQSITL---ILEDDFNKQVTLGRGGQILTSPNQGFNLNGIV 514
               + L    C       C++SI +    L  + +  + +   G++++ P  G N+    
Sbjct: 1984 -LEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNM---- 2038

Query: 515  EIQTLSSLFILLKTT-FGLKILFAIDGERIYIQLT-SAWKRRTLGLCGTFNGNIRDDFLS 572
            E+    ++   ++    G    F        +QL+   +  +T GLCG  + N  +DF+ 
Sbjct: 2039 EVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFML 2098

Query: 573  PSGMIEGTPQLHANAWRVS---STCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQELFAP 629
              G +    +     W V     TC          P    Q  +  ++HC V+   LFA 
Sbjct: 2099 RDGTVTTDWKTLVQEWTVQRPGQTC---------QPILEEQCLVPDSSHCQVLLLPLFAE 2149

Query: 630  CHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKG 689
            CH  ++P  +Y +C+ D+C      +C  +A YA+LC  +GV +D+RT   FCA+ C   
Sbjct: 2150 CHKVLAPATFYAICQQDSCH--QEQVCEVIASYAHLCRTNGVCVDWRTP-DFCAMSCPPS 2206

Query: 690  MLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHC-RC----- 743
            ++Y+HC   C   C    +   C D  +EGC CP  K   +    CVP   C +C     
Sbjct: 2207 LVYNHCEHGCPRHCD--GNVSSCGDHPSEGCFCPPDKVMLE--GSCVPEEACTQCIGEDG 2262

Query: 744  --HYRGSVYQPGELIPTPSGLCQCSNG-TVKCDELATPSA 780
              H     + P      P  +C C +G  V C     P+A
Sbjct: 2263 VQHQFLEAWVPDH---QPCQICTCLSGRKVNCTTQPCPTA 2299



 Score =  115 bits (289), Expect = 4e-25
 Identities = 106/373 (28%), Positives = 149/373 (39%), Gaps = 38/373 (10%)

Query: 63   ICKTWGQYHFETFDGIYYYFPGNCSYI-FAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            +C      H  TFDG  +   G+CSY+ F     DLE    V +HN     G+   C +S
Sbjct: 1949 VCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQDLE----VILHNGACSPGARQGCMKS 2004

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFG-----FSLAW 176
            I +  S          E+  NG  +++P   G + +  +   I+ +  F      F+   
Sbjct: 2005 IEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVN-VYGAIMHEVRFNHLGHIFTFTP 2063

Query: 177  DGISGIYLKLS-EDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT 235
               +   L+LS +    K+ GLCG  ++  ++DF++     T D       W+VQ P  T
Sbjct: 2064 QN-NEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQT 2122

Query: 236  KCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDD 295
               +       P SS           CQ+LL   F  CH+ + P  + A C  D C    
Sbjct: 2123 CQPILEEQCLVPDSS----------HCQVLLLPLFAECHKVLAPATFYAICQQDSC---H 2169

Query: 296  DETYCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQC 354
             E  C     YA  C   G  + DWR  DF  C   C  S V+  C   CP  C      
Sbjct: 2170 QEQVCEVIASYAHLCRTNGVCV-DWRTPDF--CAMSCPPSLVYNHCEHGCPRHCDGNVSS 2226

Query: 355  LGSNLHCLDGCYCPDGLVMDNGTCISLENCP--CGFHGLAY---SVGSKIEQECTECVCV 409
             G   H  +GC+CP   VM  G+C+  E C    G  G+ +          Q C  C C+
Sbjct: 2227 CGD--HPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCL 2284

Query: 410  GG-VWNCTEQDCP 421
             G   NCT Q CP
Sbjct: 2285 SGRKVNCTTQPCP 2297



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 108/501 (21%), Positives = 173/501 (34%), Gaps = 110/501 (21%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTEP 1340
            Y  C +PC +TC             V+GC   CP+  +LDE    CV   +C P + +  
Sbjct: 301  YRQCVSPCARTCQSLHINEMCQERCVDGCS--CPEGQLLDEGL--CVESTEC-PCVHSGK 355

Query: 1341 TLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNMEWQ 1400
                                           P T L           DC+  IC N +W 
Sbjct: 356  RY----------------------------PPGTSLS---------RDCNTCICRNSQW- 377

Query: 1401 LYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAALY 1460
                                           C   ECP  C +  +    +FD       
Sbjct: 378  ------------------------------ICSNEECPGECLVTGQSHFKSFDNRYFTFS 407

Query: 1461 SMASYILVRIPGE---IIVAHIEKCSMNQAPSGRISGLCFKKLNVTTP-IHKIIVN-RLA 1515
             +  Y+L R   +    IV    +C+ ++        +C + + V  P +H  +V  +  
Sbjct: 408  GICQYLLARDCQDHSFSIVIETVQCADDR------DAVCTRSVTVRLPGLHNSLVKLKHG 461

Query: 1516 RKVEVDSIVVPLPFSSQELSIEDSGSMYV-ITTPAGLIIKWSH----LTGIIDIHFGFRF 1570
              V +D   V LP    +L I+ + +  V ++    L + W      L  +  ++ G   
Sbjct: 462  AGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAG--- 518

Query: 1571 NLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCT 1630
                 T GLCG  N +  DD    +G     +ED G    +W++    +   ++    C 
Sbjct: 519  ----KTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFG---NAWKLHGDCQDLQKQHSDPCA 571

Query: 1631 EHD-----CSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVA 1682
             +        +   +L    F  CH  VSP  +   C     + +      C AL++Y A
Sbjct: 572  LNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAA 631

Query: 1683 LCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCK 1742
             C    + + WR P  C L+CP+G+ Y  C  PC   TC +  +          E C C 
Sbjct: 632  ACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNL-TCRSLSYPDEECNEACLEGCFCP 690

Query: 1743 VGTILHRPHSAQCIPEKECAC 1763
             G  L+      C+P+ +C C
Sbjct: 691  PG--LYMDERGDCVPKAQCPC 709



 Score = 84.7 bits (208), Expect = 9e-16
 Identities = 63/271 (23%), Positives = 113/271 (41%), Gaps = 17/271 (6%)

Query: 847  YPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV-CS 905
            + CP VCT    RH  +FDG  +     C   L ++ +  D+ VI  N  C       C 
Sbjct: 1944 WTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQ-DLEVILHNGACSPGARQGCM 2002

Query: 906  KSVLISVGDTEIYLND----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILW 961
            KS+ +      + L+     T   +  S  ++       ++ A  + V +     I    
Sbjct: 2003 KSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFT 2062

Query: 962  DRKTTIHIKVGPQ-WKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP 1020
             +     +++ P+ + +K  GLCG  D+  +ND    +     + +     W +   + P
Sbjct: 2063 PQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTV---QRP 2119

Query: 1021 DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCEC 1080
             +T +P    Q   P +   C +L   +FA C  V+   +F   C +D+C+       E 
Sbjct: 2120 GQTCQPILEEQCLVPDSS-HCQVLLLPLFAECHKVLAPATFYAICQQDSCHQ------EQ 2172

Query: 1081 LCTSIAAYAYKCCQEGISIHWRSSTVCSLDC 1111
            +C  IA+YA+ C   G+ + WR+   C++ C
Sbjct: 2173 VCEVIASYAHLCRTNGVCVDWRTPDFCAMSC 2203



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 90/341 (26%), Positives = 131/341 (38%), Gaps = 35/341 (10%)

Query: 1440 RCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKK 1499
            RCS+     + TFDG+   +YS A Y    + G           +    +G+   L    
Sbjct: 34   RCSLFGSDFVNTFDGS---MYSFAGYCSYLLAGGCQKRSFS--IIGDFQNGKRVSLSVY- 87

Query: 1500 LNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLT 1559
            L     IH  +   + +  +     V +P++S+ L +E     Y ++  A   +     +
Sbjct: 88   LGEFFDIHLFVNGTVTQGDQR----VSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGS 143

Query: 1560 GIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE 1619
            G   +    R+   + T GLCG  N   +DD   Q GT+ ++  D   F  SW +    +
Sbjct: 144  GNFQVLLSDRY--FNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYD---FANSWALSSGEQ 198

Query: 1620 VTMRR--PVRNCTEHD-------CSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYT 1667
               R   P  +C             QC  L +  +F  CH  V PE F   CEK      
Sbjct: 199  WCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECA 258

Query: 1668 YFWNYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWF 1726
                  C AL  Y   C +  + +  W     CS  CP G EY+ CV PC ARTC  Q  
Sbjct: 259  GGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPC-ARTC--QSL 315

Query: 1727 YGHTSCLNLRED-CVCKVGTILHRPHSAQCIPEKECACTDS 1766
            + +  C     D C C  G +L       C+   EC C  S
Sbjct: 316  HINEMCQERCVDGCSCPEGQLL---DEGLCVESTECPCVHS 353



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 30/56 (53%), Positives = 33/56 (58%), Gaps = 1/56 (1%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDC 1332
            CEWRY  CA  C  TC  PE LAC  +  VEGC  +CP   ILDE+   CV P DC
Sbjct: 1142 CEWRYNSCAPACQVTCQHPEPLACP-VQCVEGCHAHCPPGKILDELLQTCVDPEDC 1196



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 89/398 (22%), Positives = 141/398 (35%), Gaps = 87/398 (21%)

Query: 1421 GRPVQVNSDIC--------CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI-- 1470
            G  V++  + C        C +  C   CS +     +TFDG          Y+LV+   
Sbjct: 839  GETVKIGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYC 898

Query: 1471 ---PGEI-IVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVP 1526
               PG   I+   + CS    PS +    C K++ +     +I       ++    + V 
Sbjct: 899  GSNPGTFRILVGNKGCSH---PSVK----CKKRVTILVEGGEI-------ELFDGEVNVK 944

Query: 1527 LPFSSQ-ELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLS-SYTEGLCGIC- 1583
             P   +    + +SG   ++     L + W       D H      L  +Y E +CG+C 
Sbjct: 945  RPMKDETHFEVVESGRYIILLLGKALSVVW-------DRHLSISVVLKQTYQEKVCGLCG 997

Query: 1584 NED--PDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRN----CTEHDCSQC 1637
            N D   ++DL   N  +  +  D G    SW++      T + P+ +    C  +   Q 
Sbjct: 998  NFDGIQNNDLTSSNLQVEEDPVDFG---NSWKVSSQCADTRKVPLDSSPATCHNNIMKQT 1054

Query: 1638 I-----DLLNRRIFIPCHDKVSPEDF----------CEKMWINYTYFWNYECDALSAYVA 1682
            +      +L   +F  C+  V PE +          CE +     +     CD ++AY  
Sbjct: 1055 MVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACF-----CDTIAAYAH 1109

Query: 1683 LCNKFDICIQWRTPDYCSLSCPEGK----------EYQPCVRPCEARTCLNQWFYGHTSC 1732
            +C +    + WRT   C  SC E             Y  C   C+  TC       H   
Sbjct: 1110 VCAQHGKVVTWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQV-TC------QHPEP 1162

Query: 1733 LNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQP 1770
            L     CV   G   H P   + + E    C D ED P
Sbjct: 1163 LACPVQCV--EGCHAHCP-PGKILDELLQTCVDPEDCP 1197


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  555 bits (1430), Expect = e-157
 Identities = 338/1131 (29%), Positives = 530/1131 (46%), Gaps = 87/1131 (7%)

Query: 47   GTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVH 106
            G+  Q      N    +C TWG +H++TFDG  + FPG C Y FA DC      + V + 
Sbjct: 20   GSELQTEGRTRNHGHNVCSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRGSYKEFAVHLK 79

Query: 107  NSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILV 166
              P       +   SI L   + + I +  H    NG  ++ P     + IEK   Y  V
Sbjct: 80   RGPG-QAEAPAGVESILLTIKD-DTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAYTKV 137

Query: 167  KTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQS-DDFIILQEDYTEDIAMFAN 225
             +  G +L W+    + L+L    +  +CGLCG+YN +QS  +F  L +        F N
Sbjct: 138  YSRAGLTLMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEF--LSDGVLFSPLEFGN 195

Query: 226  SWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIAS 285
               +  PD           P  CS      E      ++L    F  C + +    Y+ +
Sbjct: 196  MQKINQPDVVCEDPEEEVAPASCSEHRAECE------RLLTAEAFADCQDLVPLEPYLRA 249

Query: 286  CVNDLCKTDDDET-YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCC 344
            C  D C+    +T  C    E++R CSHAG    +WR     C   C  + V+ +  S C
Sbjct: 250  CQQDRCRCPGGDTCVCSTVAEFSRQCSHAGGRPGNWRTA-TLCPKTCPGNLVYLESGSPC 308

Query: 345  PPTCTFEKQCLGSNLHCLDGCYCPDGLVMDN---GTCISLENCPCGFHGLAYSVGSKIEQ 401
              TC+  +       H +DGC+CP+G V D+     C+ +  C C  HG  Y+ G +I  
Sbjct: 309  MDTCSHLEVSSLCEEHRMDGCFCPEGTVYDDIGDSGCVPVSQCHCRLHGHLYTPGQEITN 368

Query: 402  ECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTI 461
            +C +CVC  G W C +  CP  C++ G SH TTFDG+ Y+F G C Y+L KG   D + +
Sbjct: 369  DCEQCVCNAGRWVCKDLPCPGTCALEGGSHITTFDGKTYTFHGDCYYVLAKGDHNDSYAL 428

Query: 462  TLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGF-NLNGIVEIQTLS 520
              + APC       CL+++ L+ +   N  V    G  +L        ++     +   S
Sbjct: 429  LGELAPCGSTDKQTCLKTVVLLADKKKNVVVFKSDGSVLLNELQVNLPHVTASFSVFRPS 488

Query: 521  SLFILLKTTFGLKILFAI-DGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG 579
            S  I++    G+++   +    ++++ L  A + +  GLCG FNG   DDF + SG++E 
Sbjct: 489  SYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGLVEA 548

Query: 580  TPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIH--QELFAPCHIYISP 636
            T    AN W+  S+C   +   + DPC++N ++  YA H C ++   +  F  CH  + P
Sbjct: 549  TGAGFANTWKAQSSCHDKLDW-LDDPCSLNIESANYAEHWCSLLKKTETPFGRCHSAVDP 607

Query: 637  GLYYQLCRHDACKC--GSSCLCNALAHYAYLCGQHGVPI-DFRTQISFCAV-VCQKGMLY 692
              YY+ C++D C C     CLC AL+ YA  C   GV +  +R  +    V  C    ++
Sbjct: 608  AEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQVF 667

Query: 693  HHCSSFCLHSCISLSSPE-QCSDDCA--EGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSV 749
             +  + C  +C SLS  +  C +  A  +GC CP+  F  D    CVP+  C C++RG  
Sbjct: 668  LYNLTTCQQTCRSLSEADSHCLEGFAPVDGCGCPDHTFL-DEKGRCVPLAKCSCYHRGLY 726

Query: 750  YQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCET 809
             + G+++      C C +G + C ++        C   K + DC   +    A       
Sbjct: 727  LEAGDVVVRQEERCVCRDGRLHCRQIRLIG--QSCTAPKIHMDC--SNLTALATSKPRAL 782

Query: 810  TCANLAMNFTCTPSSPCISGCVCAPGV--------------------------------- 836
            +C  LA  +  T    C+SGCVC  G+                                 
Sbjct: 783  SCQTLAAGYYHT---ECVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVDC 839

Query: 837  ----CRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDC-----QVFLIKSADDSD 887
                C+RG + CT   C   C+IYG  HY +FDG  YD+   C     Q +  +++    
Sbjct: 840  NTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGS 899

Query: 888  ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLND--TPYKQKQSGFFLENKSTYQLWKAG 945
             S+I +N  C    + CSK++ I +G TE+ L D      Q+  G  +     Y   + G
Sbjct: 900  FSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHV----AYTTREVG 955

Query: 946  YYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNA 1005
             Y+VV      I ++WD++TT+ IK+ P +K  + GLCGNFD  ++ND TT +++ V + 
Sbjct: 956  QYLVVE-SSTGIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSE 1014

Query: 1006 RVFGDSW-ALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKN 1064
              FG+SW     C       +PC  + ++  +A+K+CSIL S +F+ C + +D   F + 
Sbjct: 1015 LDFGNSWKEAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEA 1074

Query: 1065 CHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
            C  D+C+C+ GGDCEC C+++A+YA +C +EG  + WR+  +C + C+YYN
Sbjct: 1075 CVHDSCSCDTGGDCECFCSAVASYAQECTKEGACVFWRTPDLCPIFCDYYN 1125



 Score =  202 bits (513), Expect = 4e-51
 Identities = 118/433 (27%), Positives = 207/433 (47%), Gaps = 35/433 (8%)

Query: 361  CLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQD 419
            C+ GC CPDGL+ D  G C+  + CPC  +   YS G+KI+ +C  C C  G W CT+  
Sbjct: 796  CVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAV 855

Query: 420  CPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV-----KGTGKDKFTITLQKAPCEQNLGL 474
            C   CS+ G  H+ TFDG++Y F G C Y+ V     + +    F+I  +  PC    G+
Sbjct: 856  CHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVPC-GTTGV 914

Query: 475  VCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKI 534
             C ++I + +      ++ L    +++   ++G +   +         +++++++ G+ +
Sbjct: 915  TCSKAIKIFMG---RTELKLEDKHRVVIQRDEGHH---VAYTTREVGQYLVVESSTGIIV 968

Query: 535  LFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTC 594
            ++      ++I+L  ++K    GLCG F+    +DF +   M+  +     N+W+ + TC
Sbjct: 969  IWD-KRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTC 1027

Query: 595  FAPVHVPVVDPCNINQQNIGYA-AHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGS- 652
              P      +PC++N     +A   C ++   +F+ CH  + P  +Y+ C HD+C C + 
Sbjct: 1028 --PDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACVHDSCSCDTG 1085

Query: 653  ---SCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-------QKGMLYHHCSSFCLHS 702
                C C+A+A YA  C + G  + +RT    C + C       +    Y  C +    +
Sbjct: 1086 GDCECFCSAVASYAQECTKEGACVFWRTP-DLCPIFCDYYNPPHECEWHYEPCGNRSFET 1144

Query: 703  CISLSS-PEQCSDDCAEGC--NCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT 758
            C +++      S    EGC   CP+ +  YE+ L  CV    C C+   + Y PG  +PT
Sbjct: 1145 CRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASVPT 1204

Query: 759  PSGL--CQCSNGT 769
                  C C+N +
Sbjct: 1205 EETCKSCVCTNSS 1217



 Score =  172 bits (435), Expect = 4e-42
 Identities = 131/485 (27%), Positives = 214/485 (44%), Gaps = 46/485 (9%)

Query: 1414 MPDCGFRGRPVQVNS-DICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILV-RIP 1471
            MP C    +PV+V   D CC  WEC C C+   +   +TFDG   +     +Y+LV  I 
Sbjct: 4453 MPTCSNGLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEIS 4512

Query: 1472 GEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNR-----LARKVEVDSIVVP 1526
              +    +   + +  P+ ++S  C + L V     ++++       +  +V+V+   V 
Sbjct: 4513 PSVDNFGVYIDNYHCDPNDKVS--CPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVA 4570

Query: 1527 LPFSSQELSIEDSGSMYVITTP-AGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNE 1585
            LP+    L +  SG  YV+  P  G+++ ++ L+  + + +       + T+G CG C  
Sbjct: 4571 LPYKKYGLEVYQSGINYVVDIPELGVLVSYNGLSFSVRLPY---HRFGNNTKGQCGTCTN 4627

Query: 1586 DPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE-------VTMRRPV-------RNCTE 1631
               DD  + +G I++N E      + W +    +        T +RP        +    
Sbjct: 4628 TTSDDCILPSGEIVSNCEAAA---DQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPH 4684

Query: 1632 HDC--SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYF--WNYECDALSAYVALCNKF 1687
             DC  S    L+   +F  CH  V P+ + +    +  +    + EC +L AY ALC + 
Sbjct: 4685 KDCTPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPGSSLECASLQAYAALCAQQ 4744

Query: 1688 DICIQWR--TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGT 1745
            +IC+ WR  T   C + CP  +EYQ C  P E  TC +     + +   L E C C  GT
Sbjct: 4745 NICLDWRNHTHGACLVECPSHREYQAC-GPAEEPTCKSSSSQQNNTV--LVEGCFCPEGT 4801

Query: 1746 ILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPD-CDE 1804
            + + P    C+  K C C   ++ PR  GE +      C    CLE GS I  +P  C +
Sbjct: 4802 MNYAPGFDVCV--KTCGCVGPDNVPREFGEHFEFDCKNCV---CLEGGSGIICQPKRCSQ 4856

Query: 1805 EPTPVCEREAEVVMGIIDKW-TCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCP 1863
            +P   C  +   +   ++   TCC+  VC C+T+LC+     C    ++     P  CCP
Sbjct: 4857 KPVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLGFEVKSKMVPGRCCP 4916

Query: 1864 QYKCE 1868
             Y CE
Sbjct: 4917 FYWCE 4921



 Score =  134 bits (338), Expect = 8e-31
 Identities = 103/373 (27%), Positives = 162/373 (43%), Gaps = 43/373 (11%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKD-CGDLEP--RYTVWVHNSPKCLGSVYSC 118
            G C  +G  H+ TFDG YY F G+CSY+  +D CG       +++   N P C  +  +C
Sbjct: 858  GTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVP-CGTTGVTC 916

Query: 119  YRSISLFFSNQE-----EIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFS 173
             ++I +F    E     + R+     + + ++ T  + +GQ        Y++V+++ G  
Sbjct: 917  SKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTRE-VGQ--------YLVVESSTGII 967

Query: 174  LAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
            + WD  + +++KL+  +KG  CGLCGN++   ++DF             F NSW      
Sbjct: 968  VIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWK----- 1022

Query: 234  DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKT 293
            +       S  P PCS           +C IL    F  CH  +DP  +  +CV+D C  
Sbjct: 1023 EAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACVHDSCSC 1082

Query: 294  D---DDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPP--TC 348
            D   D E +C A   YA+ C+  G  +  WR     C   CD      +C     P    
Sbjct: 1083 DTGGDCECFCSAVASYAQECTKEGACV-FWRTP-DLCPIFCDYYNPPHECEWHYEPCGNR 1140

Query: 349  TFEKQCLGSNLHC------LDGCY--CPDGLVM---DNGTCISLENCPCGFHGLAYSVGS 397
            +FE     + +H       L+GCY  CP    +   D   C++ + C C      Y  G+
Sbjct: 1141 SFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGA 1200

Query: 398  KI--EQECTECVC 408
             +  E+ C  CVC
Sbjct: 1201 SVPTEETCKSCVC 1213



 Score =  128 bits (321), Expect = 7e-29
 Identities = 135/518 (26%), Positives = 185/518 (35%), Gaps = 93/518 (17%)

Query: 415  CTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK--GTGKDKFTITLQKAPCEQNL 472
            C   +C   C+  GD H+ TFDG +YS+ G C Y+LV+      D F + +    C+ N 
Sbjct: 4472 CWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPND 4531

Query: 473  GLVCLQSITLILEDD-----------FNKQVTLGRGGQILTSPNQGF-----NLNGIVEI 516
             + C +++ +  E                QV + R    L     G       +N +V+I
Sbjct: 4532 KVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDI 4591

Query: 517  QTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGM 576
              L  L      +F +++ +   G              T G CGT      DD + PSG 
Sbjct: 4592 PELGVLVSYNGLSFSVRLPYHRFG------------NNTKGQCGTCTNTTSDDCILPSGE 4639

Query: 577  IEGTPQLHANAWRV-----------SSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQE 625
            I    +  A+ W V           SST   P             ++   +  C +I   
Sbjct: 4640 IVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTPSPLCQLIKDS 4699

Query: 626  LFAPCHIYISPGLYYQLCRHDAC-KCGSSCLCNALAHYAYLCGQHGVPIDFRTQI-SFCA 683
            LFA CH  + P  YY  C  D+C   GSS  C +L  YA LC Q  + +D+R      C 
Sbjct: 4700 LFAQCHALVPPQHYYDACVFDSCFMPGSSLECASLQAYAALCAQQNICLDWRNHTHGACL 4759

Query: 684  VVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKF-YEDTLNFCVPIF--- 739
            V C     Y  C      +C S SS +Q +    EGC CPEG   Y    + CV      
Sbjct: 4760 VECPSHREYQACGPAEEPTCKS-SSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCV 4818

Query: 740  ------------------HCRCHYRGS--VYQPGELIPTPSGLC---------------Q 764
                              +C C   GS  + QP      P   C                
Sbjct: 4819 GPDNVPREFGEHFEFDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGTYLATEVNPADT 4878

Query: 765  CSNGTV-KCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPS 823
            C N TV KC+         +CP G E      P    P     CE+    +  N    P 
Sbjct: 4879 CCNITVCKCNTSLCKEKPSVCPLGFEVKSKMVPGRCCPF--YWCESKGVCVHGNAEYQPG 4936

Query: 824  SPCISG----CVCAPGVCRRGMFN---CTYYPCPAVCT 854
            SP  S     CVC   V    + N   CT+ PC   C+
Sbjct: 4937 SPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCS 4974



 Score =  122 bits (306), Expect = 4e-27
 Identities = 93/372 (25%), Positives = 156/372 (41%), Gaps = 27/372 (7%)

Query: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120
            D  C  WG  H+ TFDG+YY + GNC+Y+  ++       + V++ N         SC R
Sbjct: 4478 DCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPNDKVSCPR 4537

Query: 121  SISLFFSNQEEIRIYGH------EIKKNGISLTLP-QTIGQIFIEKLADYILVKTTFGFS 173
            ++ +    QE +    H      +++ N  ++ LP +  G    +   +Y++     G  
Sbjct: 4538 TLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDIPELGVL 4597

Query: 174  LAWDGISGIYLKLSEDHKGKSC-GLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTP 232
            ++++G+S   ++L     G +  G CG   +  SDD I+   +   +    A+ W V  P
Sbjct: 4598 VSYNGLS-FSVRLPYHRFGNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQWLVNDP 4656

Query: 233  DDTKCVLTPSDFPNPCSSGMPAFEAIFFK-------CQILLQFPFLSCHEYIDPYLYIAS 285
                C  + S    P  +     +    K       CQ++    F  CH  + P  Y  +
Sbjct: 4657 SKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTPSPLCQLIKDSLFAQCHALVPPQHYYDA 4716

Query: 286  CVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRD-DFPACTDKCDDSFVHRDCISCC 344
            CV D C        C +   YA  C+     + DWR+    AC  +C     HR+  +C 
Sbjct: 4717 CVFDSCFMPGSSLECASLQAYAALCAQQNICL-DWRNHTHGACLVECPS---HREYQACG 4772

Query: 345  P---PTCTFEKQCLGSNLHCLDGCYCPDGLV-MDNGTCISLENCPC-GFHGLAYSVGSKI 399
            P   PTC        +N   ++GC+CP+G +    G  + ++ C C G   +    G   
Sbjct: 4773 PAEEPTCK-SSSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVPREFGEHF 4831

Query: 400  EQECTECVCVGG 411
            E +C  CVC+ G
Sbjct: 4832 EFDCKNCVCLEG 4843



 Score =  107 bits (267), Expect = 1e-22
 Identities = 87/354 (24%), Positives = 127/354 (35%), Gaps = 55/354 (15%)

Query: 1903 CVCESCT-KPVPLC-HDGEFLTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKE 1960
            C  + C+ KPV  C  DG +L  ++N    CC    C C  +LC      C     +  +
Sbjct: 4849 CQPKRCSQKPVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLGFEVKSK 4908

Query: 1961 NVSGQCCPTWHCECNCENLVMPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSV 2020
             V G+CCP                                    Y CE   VCV      
Sbjct: 4909 MVPGRCCPF-----------------------------------YWCESKGVCVHGNAEY 4933

Query: 2021 LNPGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGC 2080
              PG  +        C    C ++ DN+T  + +  T V C+  C        +P +  C
Sbjct: 4934 -QPGSPVYS----SKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGE--C 4986

Query: 2081 CGTCKNVSCKFHMENGTSVVYAVG---STWHYNCTTYECVKTDEGAIILNYTMVCPPFNE 2137
            C  C+   C     +   V+   G   S    NCT + CVK     I     + CP F+ 
Sbjct: 4987 CKKCEQTHCIIKRPDNQHVILKPGDFKSDPKNNCTFFSCVKIHNQLISSVSNITCPNFDA 5046

Query: 2138 TECKMNEGIVKLYNEGCCKIC--KREERI-CQKVIIKSVIRKQDCMSQSPINVASCDGKC 2194
            + C    G +     GCCK C  + E R+ C  V + + +    C     +N   C G C
Sbjct: 5047 SICI--PGSITFMPNGCCKTCTPRNETRVPCSTVPVTTEVSYAGCTKTVLMN--HCSGSC 5102

Query: 2195 PSATIYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTCQ 2248
             +  +Y+   ++    C CC+E       V L C  NG  + +T      C CQ
Sbjct: 5103 GTFVMYSAKAQALDHSCSCCKEEKTSQREVVLSCP-NGGSLTHTYTHIESCQCQ 5155



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 76/307 (24%), Positives = 121/307 (39%), Gaps = 33/307 (10%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDS--DISVIAQNKKCFDND 901
            C ++ C   CT +GD HY +FDGL Y Y  +C   L++    S  +  V   N  C  ND
Sbjct: 4472 CWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPND 4531

Query: 902  IVCSKSVLISVGDTEIYLNDTPYKQ---------KQSGFFLENKSTYQLWKAGYYIVVYF 952
             V     LI   +T+  L  T +           +Q+      K   +++++G   VV  
Sbjct: 4532 KVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDI 4591

Query: 953  PEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW 1012
            PE  + + ++  +        ++ N   G CG     TS+D    +   V N     D W
Sbjct: 4592 PELGVLVSYNGLSFSVRLPYHRFGNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQW 4651

Query: 1013 ALGQCESP------DETIKPCEA---------HQNKFPYAKKECSILYSDIFASCRNVID 1057
             +     P        T +P            H++  P     C ++   +FA C  ++ 
Sbjct: 4652 LVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTP--SPLCQLIKDSLFAQCHALVP 4709

Query: 1058 VTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSST--VCSLDCEYYN 1115
               +   C  D+C    G   EC   S+ AYA  C Q+ I + WR+ T   C ++C  + 
Sbjct: 4710 PQHYYDACVFDSCFMP-GSSLEC--ASLQAYAALCAQQNICLDWRNHTHGACLVECPSHR 4766

Query: 1116 EGLGEGP 1122
            E    GP
Sbjct: 4767 EYQACGP 4773



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 97/463 (20%), Positives = 157/463 (33%), Gaps = 90/463 (19%)

Query: 1421 GRPVQVNSDIC--------CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPG 1472
            G  ++V+ + C        C +  C   CS+      ITFDG         SY+ V+   
Sbjct: 832  GAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQ--- 888

Query: 1473 EIIVAHIEKCSMNQA-----------PSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVD 1521
                   + C  N +           P G     C K +       KI + R   K+E  
Sbjct: 889  -------DYCGQNSSLGSFSIITENVPCGTTGVTCSKAI-------KIFMGRTELKLEDK 934

Query: 1522 SIVVPLPFSSQELSI--EDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGL 1579
              VV        ++    + G   V+ +  G+I+ W   T +      F     SY   +
Sbjct: 935  HRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKRTTV------FIKLAPSYKGTV 988

Query: 1580 CGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPV--------RN 1628
            CG+C   +   ++D   ++  ++++  D G    SW+   +       P         R+
Sbjct: 989  CGLCGNFDHRSNNDFTTRDHMVVSSELDFG---NSWKEAPTCPDVSTNPEPCSLNPHRRS 1045

Query: 1629 CTEHDCSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVAL 1683
              E  CS    +L   +F  CH KV P+ F   C     +     + EC   A+++Y   
Sbjct: 1046 WAEKQCS----ILKSSVFSICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQE 1101

Query: 1684 CNKFDICIQWRTPDYCSLSCPEGKEYQPC---VRPCEAR---TCLNQWFYGHTSCLNLRE 1737
            C K   C+ WRTPD C + C        C     PC  R   TC           ++  E
Sbjct: 1102 CTKEGACVFWRTPDLCPIFCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLE 1161

Query: 1738 DCV--CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795
             C   C     ++     +C+   +C C   +        +      E T   C+     
Sbjct: 1162 GCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASV----PTEETCKSCV----- 1212

Query: 1796 IPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTL 1838
                  C      VC  E   ++        C  E+CG + T+
Sbjct: 1213 ------CTNSSQVVCRPEEGKILNQTQDGAFCYWEICGPNGTV 1249



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 78/357 (21%), Positives = 136/357 (38%), Gaps = 43/357 (12%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSM--NQAPS 1489
            C +  CP  C++     I TFDG     +    Y+L +  G+    H +  ++    AP 
Sbjct: 382  CKDLPCPGTCALEGGSHITTFDGKTYTFHGDCYYVLAK--GD----HNDSYALLGELAPC 435

Query: 1490 GRI-SGLCFKKLNVTTPIHK-IIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
            G      C K + +     K ++V +    V ++ + V LP  +   S+    S +++ +
Sbjct: 436  GSTDKQTCLKTVVLLADKKKNVVVFKSDGSVLLNELQVNLPHVTASFSVFRPSSYHIMVS 495

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGL 1607
             A  +     L  ++ +            +GLCG  N    DD +  +G +    E  G 
Sbjct: 496  MAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGLV----EATGA 551

Query: 1608 -FIESWEIEKSFE---------VTMRRPVRNCTEHDCSQCIDLLNR--RIFIPCHDKVSP 1655
             F  +W+ + S            ++     N  EH CS    LL +    F  CH  V P
Sbjct: 552  GFANTWKAQSSCHDKLDWLDDPCSLNIESANYAEHWCS----LLKKTETPFGRCHSAVDP 607

Query: 1656 EDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQWRTPDYCSL---SCPEGKEY 1709
             ++ ++   +     N E   C ALS+Y   C    + +       C+    SCP  + +
Sbjct: 608  AEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQVF 667

Query: 1710 QPCVRPCEARTCLNQWFYGHTSCLN---LREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               +  C+ +TC        + CL      + C C   T L      +C+P  +C+C
Sbjct: 668  LYNLTTCQ-QTC-RSLSEADSHCLEGFAPVDGCGCPDHTFL--DEKGRCVPLAKCSC 720



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 62/259 (23%), Positives = 101/259 (38%), Gaps = 32/259 (12%)

Query: 1520 VDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGI-IDIHFGFRFNLSSYTEG 1578
            ++  VV  P  S  L IE S +   + + AGL + W+    + +++   FR    ++T G
Sbjct: 112  LNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLTLMWNREDALMLELDTKFR----NHTCG 167

Query: 1579 LCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR-----NCTEHD 1633
            LCG  N        + +G + + +E    F    +I +  +V    P       +C+EH 
Sbjct: 168  LCGDYNGLQSYSEFLSDGVLFSPLE----FGNMQKINQP-DVVCEDPEEEVAPASCSEHR 222

Query: 1634 CSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVALCNKFDIC 1690
             ++C  LL    F  C D V  E +   C++            C  ++ +   C+     
Sbjct: 223  -AECERLLTAEAFADCQDLVPLEPYLRACQQDRCRCPGGDTCVCSTVAEFSRQCSHAGGR 281

Query: 1691 I-QWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLRED-----CVCKVG 1744
               WRT   C  +CP    Y     PC   TC       H    +L E+     C C  G
Sbjct: 282  PGNWRTATLCPKTCPGNLVYLESGSPC-MDTC------SHLEVSSLCEEHRMDGCFCPEG 334

Query: 1745 TILHRPHSAQCIPEKECAC 1763
            T+      + C+P  +C C
Sbjct: 335  TVYDDIGDSGCVPVSQCHC 353



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 27/71 (38%), Positives = 34/71 (47%), Gaps = 4/71 (5%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKF-LPPVEGCLPYCPKNM-ILDEVTLKCVYPRDCIP 1334
            CEW YEPC    F+TC     +     +  +EGC P CPK+  I +E   KCV    C  
Sbjct: 1130 CEWHYEPCGNRSFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGC 1189

Query: 1335 VIPTEPTLMPP 1345
             +  E T  PP
Sbjct: 1190 YV--EDTHYPP 1198



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 3/70 (4%)

Query: 1768 DQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCC 1827
            D PR   E W   + +C +  C  N ++  ++ +C+  P P C    + V  + D   CC
Sbjct: 4416 DPPRQENETW--WLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQPVR-VEDPDGCC 4472

Query: 1828 SKEVCGCDTT 1837
                C C  T
Sbjct: 4473 WHWECDCYCT 4482



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 25/101 (24%), Positives = 40/101 (39%), Gaps = 13/101 (12%)

Query: 1909 TKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNLC---------PMPLLNCAEDMNLVK 1959
            TKP P C D +    + N T + C  +   C+ N           P P+  C+  +  V+
Sbjct: 4407 TKP-PECPDFDPPRQE-NETWWLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQPVR 4464

Query: 1960 ENVSGQCCPTWHCECNCENLVMPTCEVGEFTAIDHNFQSDC 2000
                  CC  W C+C C     P      F  + +++Q +C
Sbjct: 4465 VEDPDGCCWHWECDCYCTGWGDP--HYVTFDGLYYSYQGNC 4503



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 21/78 (26%), Positives = 32/78 (41%), Gaps = 16/78 (20%)

Query: 1800 PDCDEEPTPVCEREAEVVMGIIDKWTC-CSKEVCGCDTTL------CETS-IPTCTNSQK 1851
            P+C +   P  E E          W C C    C  + T+      CE   +PTC+N  +
Sbjct: 4410 PECPDFDPPRQENETW--------WLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQ 4461

Query: 1852 LIVGHSPLSCCPQYKCEC 1869
             +    P  CC  ++C+C
Sbjct: 4462 PVRVEDPDGCCWHWECDC 4479


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score =  546 bits (1407), Expect = e-155
 Identities = 340/1127 (30%), Positives = 518/1127 (45%), Gaps = 106/1127 (9%)

Query: 58   NGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHN----SPKCLG 113
            NGR  +C TWG +H++TFDG  + FPG C+Y+F++ C      + V +      S   + 
Sbjct: 73   NGR--VCSTWGDFHYKTFDGDVFRFPGLCNYVFSEHCRAAYEDFNVQLRRGLVGSRPVVT 130

Query: 114  SVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFS 173
             V    + + L  SN          +  NG    LP +   + +E+  DYI V      +
Sbjct: 131  RVVIKAQGLVLEASNGS--------VLINGQREELPYSRTGLLVEQSGDYIKVSIRLVLT 182

Query: 174  LAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAM----FANSWSV 229
              W+G     L+L   +  ++CGLCG++N + +       E Y  +  +    F N   +
Sbjct: 183  FLWNGEDSALLELDPKYANQTCGLCGDFNGLPA-----FNEFYAHNARLTPLQFGNLQKL 237

Query: 230  QTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVND 289
              P + +C   P   P P  +     E I  +   LL   F  CH  +D   Y+A+C  D
Sbjct: 238  DGPTE-QC---PDPLPLPAGNCTDE-EGICHRT--LLGPAFAECHALVDSTAYLAACAQD 290

Query: 290  LCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCT 349
            LC+       C    EY+R C+HAG   ++WR     C   C  +  H++C S C  TC+
Sbjct: 291  LCRCPTCP--CATFVEYSRQCAHAGGQPRNWRCP-ELCPRTCPLNMQHQECGSPCTDTCS 347

Query: 350  FEKQCLGSNLHCLDGCYCPDG---LVMDNGT---CISLENCPCGFHGLAYSVGSKIEQEC 403
              ++      HC+DGC+CP G    V+D+ T   C+ L  CPC   G  YS G+     C
Sbjct: 348  NPQRAQLCEDHCVDGCFCPPGRSCTVLDDITHSGCLPLGQCPCTHGGRTYSPGTSFNTTC 407

Query: 404  TECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITL 463
            + C C GG+W C +  CP  CSV G +H +T+D + Y   G C Y+L K      FT+  
Sbjct: 408  SSCTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYVLSKKCADSSFTVLA 467

Query: 464  QKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI-VEIQTLSSL 522
            +   C       CL+++TL L+           GG  L S      L+   + + T SS 
Sbjct: 468  ELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQLPLSAANITLFTPSSF 527

Query: 523  FILLKTTFGLKILFA-IDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTP 581
            FI+++T  GL++L   +   +++++L  A + +  GLCG FN N  DDF + SG++E T 
Sbjct: 528  FIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFNQNQADDFTALSGVVEATG 587

Query: 582  QLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQ--ELFAPCHIYISPGL 638
               AN W+  + C A       DPC+++ +N  YA H C  +      F+ CH  I+P  
Sbjct: 588  AAFANTWKAQAAC-ANARNSFEDPCSLSVENENYARHWCSRLTDPNSAFSRCHSIINPKP 646

Query: 639  YYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVV-CQKGMLYHH 694
            ++  C  D C C  S  CLC AL+ Y + C   GV + D+R  +    +  C K   Y +
Sbjct: 647  FHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQRYAY 706

Query: 695  CSSFCLHSCISLSSPE-QCSDDCA--EGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQ 751
                C  +C  LS  +  CS      +GC CP G F  D    CVP   C C+  G+V  
Sbjct: 707  VVDACQPTCRGLSEADVTCSVSFVPVDGCTCPAGTFLNDA-GACVPAQECPCYAHGTVLA 765

Query: 752  PGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTC 811
            PGE++     +C C+ G + C   +   +   C     Y DC       P  G  C  +C
Sbjct: 766  PGEVVHDEGAVCSCTGGKLSCLGASLQKSTG-CAAPMVYLDCSNSSAGTP--GAECLRSC 822

Query: 812  ANLAMNFTCTPSSPCISGCVCAPGV----------------------------------- 836
              L +      S+ C+SGCVC PG+                                   
Sbjct: 823  HTLDVGCF---STHCVSGCVCPPGLVSDGSGGCIAEEDCPCVHNEATYKPGETIRVDCNT 879

Query: 837  --CRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK-----SADDSDIS 889
              CR   + C++  C   C  YGD H+ +FDG  Y +   C+  L +     +       
Sbjct: 880  CTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFR 939

Query: 890  VIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIV 949
            ++ +N  C      CSK++ + V   E+ L +  +K    G        Y++   G ++V
Sbjct: 940  IVTENIPCGTTGTTCSKAIKLFVESYELILQEGTFKAVARG--PGGDPPYKIRYMGIFLV 997

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
            +      + + WDRKT++ I++   +K ++ GLCGNFD    ND  T +   V +A  FG
Sbjct: 998  I--ETHGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGDALEFG 1055

Query: 1010 DSWALG-QCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHED 1068
            +SW L   C        PC A+  +  +A+K+CSIL+   FA+CR+ +D T + + C  D
Sbjct: 1056 NSWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACRSQVDSTKYYEACVND 1115

Query: 1069 TCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
             C C+ GGDCEC CT++AAYA  C   G+ + WR+   C L C++YN
Sbjct: 1116 ACACDSGGDCECFCTAVAAYAQACHDAGLCVSWRTPDTCPLFCDFYN 1162



 Score =  134 bits (337), Expect = 1e-30
 Identities = 161/691 (23%), Positives = 250/691 (36%), Gaps = 120/691 (17%)

Query: 1409 PKDVEMPDCGFRGRPVQVN--SDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYI 1466
            PK V    C  +  P++V+  S  C   +EC C CSM       TFDG +       +Y+
Sbjct: 5044 PKPVANVTCVNKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTSYTFRGNCTYV 5103

Query: 1467 LVR-----IPGEIIVAHIEKCSMNQAPSG----RISGLCFKKLNVTTPIHKIIVNRLARK 1517
            L+R          +      C+ +   +     R   + +K +++   +  ++  +    
Sbjct: 5104 LMREIHARFGNLSLYLDNHYCTASATAAAARCPRALSIHYKSMDIVLTV-TMVHGKEEGL 5162

Query: 1518 VEVDSIVVPLPFSSQELSIEDSGS--MYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSY 1575
            +  D I V   FS   + +   G+  M V     G+ + ++       + +    N    
Sbjct: 5163 ILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFNGQVFQARLPYSLFHN---N 5219

Query: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE------------VTMR 1623
            TEG CG C  +  DD   ++GT   + +D+    ++W +  S +             +  
Sbjct: 5220 TEGQCGTCTNNQRDDCLQRDGTTAASCKDMA---KTWLVPDSRKDGCWAPTGTPPTASPA 5276

Query: 1624 RPVRNC-TEHDC--SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYF-WNYECDALSA 1679
             PV +  T   C      DL+  ++F  CH+ V P  F      ++        C +L A
Sbjct: 5277 APVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDHCRGRLEVPCQSLEA 5336

Query: 1680 YVALCNKFDICIQWR--TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLRE 1737
            Y  LC    +C  WR  T   C L+CP  K Y+PC  P +  TC ++          + E
Sbjct: 5337 YAELCRARGVCSDWRGATGGLCDLTCPPTKVYKPC-GPIQPATCNSR--NQSPQLEGMAE 5393

Query: 1738 DCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIP 1797
             C C    IL   H   C+  + C C   +  P+  GE W      C   +   +    P
Sbjct: 5394 GCFCPEDQILFNAHMGICV--QACPCVGPDGFPKFPGERWVSNCQSCVCDEGSVSVQCKP 5451

Query: 1798 IEPDCDEEPTPVCEREAEV-VMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGH 1856
            +  D   +P P C R   V V     +  CC + VC C+TT C  S+P C   Q+ I   
Sbjct: 5452 LPCDAQGQPPP-CNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPVCPPGQESICTQ 5510

Query: 1857 SPLSCCPQYKCE----------------------CDPLKCPSISTP----ECRED----- 1885
                CCP ++C                       C    C S  T     +C+ED     
Sbjct: 5511 EEGDCCPTFRCRPQLCSYNGTFYGVGATFPGALPCHMCTCLSGDTQDPTVQCQEDACNNT 5570

Query: 1886 ---QFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVD---LNSTHFCCPQYYCVC 1939
               Q     R    CC    CV  +C  P     DG+ + ++   +NS    C  Y C  
Sbjct: 5571 TCPQGFEYKRVAGQCCGE--CVQTACLTP-----DGQPVQLNETWVNSHVDNCTVYLCEA 5623

Query: 1940 EPN---LCPMP------------------LLNCAEDMNLVKENVSGQCCPTWHCECNCEN 1978
            E     L P P                    +C ED   V+ N +      WH  C  E 
Sbjct: 5624 EGGVHLLTPQPASCPDVSSCRGSLRKTGCCYSCEEDSCQVRINTT----ILWHQGCETE- 5678

Query: 1979 LVMPTCE-----VGEFTAIDHNFQSDCGCIQ 2004
            + +  CE       +++A     Q  C C Q
Sbjct: 5679 VNITFCEGSCPGASKYSAEAQAMQHQCTCCQ 5709



 Score =  120 bits (301), Expect = 2e-26
 Identities = 136/527 (25%), Positives = 207/527 (39%), Gaps = 68/527 (12%)

Query: 419  DCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGK--DKFTITLQKAPCEQNLGLV- 475
            +C   CS+ G SH++TFDG  Y+F G C Y+L++         ++ L    C  +     
Sbjct: 5073 ECECICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAA 5132

Query: 476  --CLQSITLILED-DFNKQVTLGRG---GQILTSP---NQGFNLNGIVEIQTLSSLFILL 526
              C +++++  +  D    VT+  G   G IL      + GF+ NG++     ++   + 
Sbjct: 5133 ARCPRALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVD 5192

Query: 527  KTTFGLKILFAIDGERIYIQLT-SAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHA 585
                G+ + F  +G+    +L  S +   T G CGT   N RDD L   G    + +  A
Sbjct: 5193 IPALGVSVTF--NGQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMA 5250

Query: 586  NAWRVSST----CFAPVHVPVV-----------DPCNINQQNIGYAAHCDVIHQELFAPC 630
              W V  +    C+AP   P              P     Q +     CD++  ++FA C
Sbjct: 5251 KTWLVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPL-----CDLMLSQVFAEC 5305

Query: 631  HIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQI-SFCAVVCQKG 689
            H  + PG ++  C  D C+      C +L  YA LC   GV  D+R      C + C   
Sbjct: 5306 HNLVPPGPFFNACISDHCRGRLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTCPPT 5365

Query: 690  MLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRGS 748
             +Y  C      +C S +   Q  +  AEGC CPE +  +   +  CV    C     G 
Sbjct: 5366 KVYKPCGPIQPATCNSRNQSPQL-EGMAEGCFCPEDQILFNAHMGICVQACPC-VGPDGF 5423

Query: 749  VYQPGELIPTPSGLCQCSNG--TVKCDELATPSAVHICPEGKEYFDC----RFPDPELPA 802
               PGE   +    C C  G  +V+C  L   +     P  +  F      R  +P  P 
Sbjct: 5424 PKFPGERWVSNCQSCVCDEGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPE 5483

Query: 803  GGVNCETTCANLAMNFTCTPSSPCISGCVCAPG---VCRRGMFNC--TYYPCPAVCTIYG 857
                C TT        TC  S P     VC PG   +C +   +C  T+   P +C+  G
Sbjct: 5484 TVCVCNTT--------TCPQSLP-----VCPPGQESICTQEEGDCCPTFRCRPQLCSYNG 5530

Query: 858  DRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVC 904
               +Y   G  +     C +    S D  D +V  Q   C  N+  C
Sbjct: 5531 T--FYGV-GATFPGALPCHMCTCLSGDTQDPTVQCQEDAC--NNTTC 5572



 Score =  106 bits (265), Expect = 2e-22
 Identities = 90/349 (25%), Positives = 137/349 (39%), Gaps = 68/349 (19%)

Query: 1905 CESCTKPVPLCHDGEFLTVDL-NSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVS 1963
            C++  +P P C+   F+TV    + + CCP+  CVC    CP  L  C      +     
Sbjct: 5454 CDAQGQPPP-CNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPVCPPGQESICTQEE 5512

Query: 1964 GQCCPTWHCECNCENLVMPTCEV-GEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLN 2022
            G CCPT+ C           C   G F  +   F     C    C   D          +
Sbjct: 5513 GDCCPTFRCRPQL-------CSYNGTFYGVGATFPGALPCHMCTCLSGDT--------QD 5557

Query: 2023 PGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCG 2082
            P              T++C E+  N+T           C +  +  +V         CCG
Sbjct: 5558 P--------------TVQCQEDACNNT----------TCPQGFEYKRVAGQ------CCG 5587

Query: 2083 TCKNVSCKFHMENGTSVVYAVGSTW---HY-NCTTYECVKTDEGAIILNYTMVCPPFNET 2138
             C   +C     +G  V   +  TW   H  NCT Y C       ++      CP  + +
Sbjct: 5588 ECVQTACL--TPDGQPV--QLNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCP--DVS 5641

Query: 2139 ECKMNEGIVKLYNEGCCKICKREERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSAT 2198
             C+ +     L   GCC  C  EE  CQ  I  +++  Q C  ++ +N+  C+G CP A+
Sbjct: 5642 SCRGS-----LRKTGCCYSC--EEDSCQVRINTTILWHQGC--ETEVNITFCEGSCPGAS 5692

Query: 2199 IYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTC 2247
             Y+   ++    C CC+E  V   +VPL+C  NG+ I++T     +C C
Sbjct: 5693 KYSAEAQAMQHQCTCCQERRVHEETVPLHCP-NGSAILHTYTHVDECGC 5740



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 101/398 (25%), Positives = 160/398 (40%), Gaps = 48/398 (12%)

Query: 63   ICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHN---SPKCLGSVYSCY 119
            IC  WG  H+ TFDG  Y F GNC+Y+  ++        ++++ N   +     +   C 
Sbjct: 5077 ICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAARCP 5136

Query: 120  RSISLFFSNQEEI----RIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTT------ 169
            R++S+ + + + +     ++G   K+ G+ L     +   F +      ++ TT      
Sbjct: 5137 RALSIHYKSMDIVLTVTMVHG---KEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDI 5193

Query: 170  --FGFSLAWDG-ISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAM--FA 224
               G S+ ++G +    L  S  H     G CG   + Q DD   LQ D T   +    A
Sbjct: 5194 PALGVSVTFNGQVFQARLPYSLFHNNTE-GQCGTCTNNQRDD--CLQRDGTTAASCKDMA 5250

Query: 225  NSWSVQTPDDTK-CVLTPSDFPNPCSSGMPAFEAIFFK-------CQILLQFPFLSCHEY 276
             +W V  PD  K     P+  P   S   P               C ++L   F  CH  
Sbjct: 5251 KTWLV--PDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAECHNL 5308

Query: 277  IDPYLYIASCVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPA-CTDKCDDSF 335
            + P  +  +C++D C+    E  C++   YA  C   G    DWR      C   C  + 
Sbjct: 5309 VPPGPFFNACISDHCR-GRLEVPCQSLEAYAELCRARGV-CSDWRGATGGLCDLTCPPTK 5366

Query: 336  VHRDCISCCPPTCTFEKQCLGSNLHCL-DGCYCPDGLVMDN---GTCISLENCPC-GFHG 390
            V++ C    P TC    Q     L  + +GC+CP+  ++ N   G C+  + CPC G  G
Sbjct: 5367 VYKPCGPIQPATCNSRNQ--SPQLEGMAEGCFCPEDQILFNAHMGICV--QACPCVGPDG 5422

Query: 391  LAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVG 428
                 G +    C  CVC  G  + + Q  P+ C   G
Sbjct: 5423 FPKFPGERWVSNCQSCVCDEG--SVSVQCKPLPCDAQG 5458



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 139/613 (22%), Positives = 212/613 (34%), Gaps = 129/613 (21%)

Query: 1421 GRPVQVNSDICC---PEWECPCR-----CSMLSELSIITFDGNNAALYSMASYILVR-IP 1471
            G  ++V+ + C      WEC  R     C    +   ITFDG+  +      YIL +   
Sbjct: 870  GETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYC 929

Query: 1472 GEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSS 1531
            G+       +      P G     C K + +    +++I+     K      V   P   
Sbjct: 930  GDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVESYELILQEGTFKA-----VARGPGGD 984

Query: 1532 QELSIEDSGSMYVITTPAGLIIKWSHLTGI-IDIHFGFRFNLSSYTEGLCGICNEDPDDD 1590
                I   G   VI T  G+ + W   T + I +H  ++  +     GLCG  +++  +D
Sbjct: 985  PPYKIRYMGIFLVIETH-GMAVSWDRKTSVFIRLHQDYKGRVC----GLCGNFDDNAIND 1039

Query: 1591 LRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDC------SQCIDLLNRR 1644
               ++ +++ +  + G    SW++  S    +  P   CT +         QC  +L+  
Sbjct: 1040 FATRSRSVVGDALEFG---NSWKLSPSCPDALA-PKDPCTANPFRKSWAQKQC-SILHGP 1094

Query: 1645 IFIPCHDKVSPEDFCEKMWINYTYFWNYE------CDALSAYVALCNKFDICIQWRTPDY 1698
             F  C  +V    + E   +N     +        C A++AY   C+   +C+ WRTPD 
Sbjct: 1095 TFAACRSQVDSTKYYEAC-VNDACACDSGGDCECFCTAVAAYAQACHDAGLCVSWRTPDT 1153

Query: 1699 CSLSC----PEGK---EYQPCVRPCEARTCLNQWFY------GHTSCLN--------LRE 1737
            C L C    P G     YQPC  PC  +TC N   +      G   C            E
Sbjct: 1154 CPLFCDFYNPHGGCEWHYQPCGAPC-LKTCRNPSGHCLVDLPGLEGCYPKCPPSQPFFNE 1212

Query: 1738 D---CVCKVG---------------TILHRPHSAQCIPE--------KECACTDSEDQPR 1771
            D   CV + G                      S  C P         + C CT  +    
Sbjct: 1213 DQMKCVAQCGCYDKDGNYYDVGARVPTAENCQSCNCTPSGIQCAHSLEACTCTYEDRTYS 1272

Query: 1772 TAGEIWN--GGIDECTLYKCLENGSIIPIEPDCDEEP--TPVCEREAEV----VMGIIDK 1823
                I+N   G+  C +  C  NG+II     C   P  TP     A V        +  
Sbjct: 1273 YQDVIYNTTDGLGACLIAICGSNGTIIRKAVACPGTPATTPFTFTTAWVPHSTTSPALPV 1332

Query: 1824 WTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCEC-DPLK------CPS 1876
             T C +EVC                      GH P         E  + L+      CP 
Sbjct: 1333 STVCVREVC---------------RWSSWYNGHRPEPGLGGGDFETFENLRQRGYQVCPV 1377

Query: 1877 ISTPECREDQF----MIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCC 1932
            ++  ECR  Q     + ++ Q+  C      +C +  +  PLCHD E   +       CC
Sbjct: 1378 LADIECRAAQLPDMPLEELGQQVDCDRMRGLMCANSQQSPPLCHDYELRVL-------CC 1430

Query: 1933 PQYYCVCEPNLCP 1945
               Y  C P+  P
Sbjct: 1431 E--YVPCGPSPAP 1441



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 69/297 (23%), Positives = 114/297 (38%), Gaps = 36/297 (12%)

Query: 846  YYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKS--ADDSDISVIAQNKKCFDNDIV 903
            +Y C  +C+++G  HY +FDG  Y +  +C   L++   A   ++S+   N  C  +   
Sbjct: 5071 HYECECICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATA 5130

Query: 904  ----CSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQ--LWKAGYYIVVY------ 951
                C +++ I     +I L  T    K+ G  L ++        K G  + V       
Sbjct: 5131 AAARCPRALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMR 5190

Query: 952  --FPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNF-----DKCTSNDMTTSNNLE--- 1001
               P   +++ ++ +          + N   G CG       D C   D TT+ + +   
Sbjct: 5191 VDIPALGVSVTFNGQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMA 5250

Query: 1002 ----VRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKE-CSILYSDIFASCRNVI 1056
                V ++R  G  WA            P  +     P   +  C ++ S +FA C N++
Sbjct: 5251 KTWLVPDSRKDG-CWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAECHNLV 5309

Query: 1057 DVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSST--VCSLDC 1111
                F   C  D C     G  E  C S+ AYA  C   G+   WR +T  +C L C
Sbjct: 5310 PPGPFFNACISDHCR----GRLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTC 5362



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 102/463 (22%), Positives = 173/463 (37%), Gaps = 46/463 (9%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGE---IIVAHIEKCSMNQAP 1488
            C +  CP  CS+     I T+D     L+   SY+L +   +    ++A + KC +    
Sbjct: 419  CQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYVLSKKCADSSFTVLAELRKCGLTDNE 478

Query: 1489 SGRISGLCFKKLNVTTPIHKIIVNRLA-RKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
            +      C K + ++       +   A   V ++SI   LP S+  +++    S +++  
Sbjct: 479  N------CLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQLPLSAANITLFTPSSFFIVVQ 532

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG- 1606
                +     L  ++ +             GLCG  N++  DD    +G +    E  G 
Sbjct: 533  TGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFNQNQADDFTALSGVV----EATGA 588

Query: 1607 LFIESWEIE-------KSFEVTMRRPV--RNCTEHDCSQCIDLLNRRIFIPCHDKVSPED 1657
             F  +W+ +        SFE      V   N   H CS+  D      F  CH  ++P+ 
Sbjct: 589  AFANTWKAQAACANARNSFEDPCSLSVENENYARHWCSRLTD--PNSAFSRCHSIINPKP 646

Query: 1658 F---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCS---LSCPEGKEYQP 1711
            F   C     N     +  C ALS+YV  C    + +       C+    +CP+ + Y  
Sbjct: 647  FHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQRYAY 706

Query: 1712 CVRPCEARTCLNQWFYGHTSCLNL--REDCVCKVGTILHRPHSAQCIPEKECACTDSEDQ 1769
             V  C+  TC        T  ++    + C C  GT L+   +  C+P +EC C  +   
Sbjct: 707  VVDACQP-TCRGLSEADVTCSVSFVPVDGCTCPAGTFLN--DAGACVPAQECPCY-AHGT 762

Query: 1770 PRTAGEIWN--GGIDECTLYKCLENGSIIPIEPDCDEEPTPV-CEREAEVVMGIIDKWTC 1826
                GE+ +  G +  CT  K    G+ +     C      + C   +    G     +C
Sbjct: 763  VLAPGEVVHDEGAVCSCTGGKLSCLGASLQKSTGCAAPMVYLDCSNSSAGTPGAECLRSC 822

Query: 1827 CSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCEC 1869
             + +V GC +T C   +  C     L+   S   C  +  C C
Sbjct: 823  HTLDV-GCFSTHC---VSGCVCPPGLVSDGSG-GCIAEEDCPC 860



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 25/57 (43%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDC 1332
            CEW Y+PC  PC KTC +P       LP +EGC P CP +    +E  +KCV    C
Sbjct: 1167 CEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKCPPSQPFFNEDQMKCVAQCGC 1223



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 64/276 (23%), Positives = 105/276 (38%), Gaps = 26/276 (9%)

Query: 1527 LPFSSQELSIEDSGSMYVITTPAGLIIKWS-HLTGIIDIHFGFRFNLSSYTEGLCGICNE 1585
            LP+S   L +E SG    ++    L   W+   + ++++   +    ++ T GLCG  N 
Sbjct: 157  LPYSRTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALLELDPKY----ANQTCGLCGDFNG 212

Query: 1586 DPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI 1645
             P  +    +   +T ++   L       E+  +  +  P  NCT+ +   C   L    
Sbjct: 213  LPAFNEFYAHNARLTPLQFGNLQKLDGPTEQCPD-PLPLPAGNCTDEE-GICHRTLLGPA 270

Query: 1646 FIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALC-NKFDICIQWRTPDYCSLSCP 1704
            F  CH  V    +      +        C     Y   C +       WR P+ C  +CP
Sbjct: 271  FAECHALVDSTAYLAACAQDLCRCPTCPCATFVEYSRQCAHAGGQPRNWRCPELCPRTCP 330

Query: 1705 EGKEYQPCVRPCEARTCLN----QWFYGHTSCLNLREDCVCKVG---TILHRPHSAQCIP 1757
               ++Q C  PC   TC N    Q    H  C+   + C C  G   T+L     + C+P
Sbjct: 331  LNMQHQECGSPC-TDTCSNPQRAQLCEDH--CV---DGCFCPPGRSCTVLDDITHSGCLP 384

Query: 1758 EKECACTDSEDQPRTAGEIWNGGIDECT----LYKC 1789
              +C CT    +  + G  +N     CT    L++C
Sbjct: 385  LGQCPCTHG-GRTYSPGTSFNTTCSSCTCSGGLWQC 419


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score =  531 bits (1368), Expect = e-150
 Identities = 342/1157 (29%), Positives = 521/1157 (45%), Gaps = 132/1157 (11%)

Query: 58   NGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHN----SPKCLG 113
            NGR  +C TWG +H++TFDG  + FPG C+Y+F++ C      + V +      S   + 
Sbjct: 729  NGR--VCSTWGDFHYKTFDGDVFRFPGLCNYVFSEHCRAAYEDFNVQLRRGLVGSRPVVT 786

Query: 114  SVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFS 173
             V    + + L  SN          +  NG    LP +   + +E+  DYI V      +
Sbjct: 787  RVVIKAQGLVLEASNGS--------VLINGQREELPYSRTGLLVEQSGDYIKVSIRLVLT 838

Query: 174  LAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAM----FANSWSV 229
              W+G     L+L   +  ++CGLCG++N + +       E Y  +  +    F N   +
Sbjct: 839  FLWNGEDSALLELDPKYANQTCGLCGDFNGLPA-----FNEFYAHNARLTPLQFGNLQKL 893

Query: 230  QTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVND 289
              P + +C   P   P P  +     E I  +   LL   F  CH  +D   Y+A+C  D
Sbjct: 894  DGPTE-QC---PDPLPLPAGNCTDE-EGICHRT--LLGPAFAECHALVDSTAYLAACAQD 946

Query: 290  LCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCT 349
            LC+       C    EY+R C+HAG   ++WR     C   C  +  H++C S C  TC+
Sbjct: 947  LCRCPTCP--CATFVEYSRQCAHAGGQPRNWRCP-ELCPRTCPLNMQHQECGSPCTDTCS 1003

Query: 350  FEKQCLGSNLHCLDGCYCPDG---LVMDNGT---CISLENCPCGFHGLAYSVGSKIEQEC 403
              ++      HC+DGC+CP G    V+D+ T   C+ L  CPC   G  YS G+     C
Sbjct: 1004 NPQRAQLCEDHCVDGCFCPPGRSCTVLDDITHSGCLPLGQCPCTHGGRTYSPGTSFNTTC 1063

Query: 404  TECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITL 463
            + C C GG+W C +  CP  CSV G +H +T+D + Y   G C Y+L K      FT+  
Sbjct: 1064 SSCTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYVLSKKCADSSFTVLA 1123

Query: 464  QKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI-VEIQTLSSL 522
            +   C       CL+++TL L+           GG  L S      L+   + + T SS 
Sbjct: 1124 ELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQLPLSAANITLFTPSSF 1183

Query: 523  FILLKTTFGLKILFA-IDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTP 581
            FI+++T  GL++L   +   +++++L  A + +  GLCG FN N  DDF + SG++E T 
Sbjct: 1184 FIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFNQNQADDFTALSGVVEATG 1243

Query: 582  QLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQ--ELFAPCHIYISPGL 638
               AN W+  + C A       DPC+++ +N  YA H C  +      F+ CH  I+P  
Sbjct: 1244 AAFANTWKAQAAC-ANARNSFEDPCSLSVENENYARHWCSRLTDPNSAFSRCHSIINPKP 1302

Query: 639  YYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVV-CQKGMLYHH 694
            ++  C  D C C  S  CLC AL+ Y + C   GV + D+R  +    +  C K   Y +
Sbjct: 1303 FHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQRYAY 1362

Query: 695  CSSFCLHSCISLSSPE-QCSDDCA--EGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQ 751
                C  +C  LS  +  CS      +GC CP G F  D    CVP   C C+  G+V  
Sbjct: 1363 VVDACQPTCRGLSEADVTCSVSFVPVDGCTCPAGTFLNDA-GACVPAQECPCYAHGTVLA 1421

Query: 752  PGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTC 811
            PGE++     +C C+ G + C   +   +   C     Y DC       P  G  C  +C
Sbjct: 1422 PGEVVHDEGAVCSCTGGKLSCLGASLQKSTG-CAAPMVYLDCSNSSAGTP--GAECLRSC 1478

Query: 812  ANLAMNFTCTPSSPCISGCVCAPGV----------------------------------- 836
              L +      S+ C+SGCVC PG+                                   
Sbjct: 1479 HTLDVGCF---STHCVSGCVCPPGLVSDGSGGCIAEEDCPCVHNEATYKPGETIRVDCNT 1535

Query: 837  --CRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK-----SADDSDIS 889
              CR   + C++  C   C  YGD H+ +FDG  Y +   C+  L +     +       
Sbjct: 1536 CTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFR 1595

Query: 890  VIAQNKKCFDNDIVCSKSVLI--------SVGDTEIYLNDTPYKQKQSGF--FLENKSTY 939
            ++ +N  C      CSK++ +        +V   +   N+   ++   GF   L    +Y
Sbjct: 1596 IVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTPDPAANEPAPREASVGFRQRLPPLQSY 1655

Query: 940  QL-------------------WKAGYY-IVVYFPEKDITILWDRKTTIHIKVGPQWKNKL 979
            +L                   +K  Y  I +      + + WDRKT++ I++   +K ++
Sbjct: 1656 ELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFIRLHQDYKGRV 1715

Query: 980  SGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALG-QCESPDETIKPCEAHQNKFPYAK 1038
             GLCGNFD    ND  T +   V +A  FG+SW L   C        PC A+  +  +A+
Sbjct: 1716 CGLCGNFDDNAINDFATRSRSVVGDALEFGNSWKLSPSCPDALAPKDPCTANPFRKSWAQ 1775

Query: 1039 KECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGIS 1098
            K+CSIL+   FA+CR+ +D T + + C  D C C+ GGDCEC CT++AAYA  C   G+ 
Sbjct: 1776 KQCSILHGPTFAACRSQVDSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHDAGLC 1835

Query: 1099 IHWRSSTVCSLDCEYYN 1115
            + WR+   C L C++YN
Sbjct: 1836 VSWRTPDTCPLFCDFYN 1852



 Score =  293 bits (751), Expect = 1e-78
 Identities = 175/568 (30%), Positives = 281/568 (49%), Gaps = 34/568 (5%)

Query: 58  NGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYS 117
           NGR  +C TWG +H++TFDG  + FPG C+Y+F++ CG     + + +  S +      S
Sbjct: 77  NGR--VCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPTLS 134

Query: 118 CYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWD 177
                 L   +   I++    +  NG  + LP +   + I++ + Y  V+   G  L W+
Sbjct: 135 RV----LMKVDGVVIQLTKGSVLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGLVLMWN 190

Query: 178 GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKC 237
               + L+L   +  K+CGLCG++N +     ++        +  F N   +  P + +C
Sbjct: 191 HDDSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDPTE-QC 248

Query: 238 VLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLS-CHEYIDPYLYIASCVNDLCKTDDD 296
                + P  CS+G       F  C+ LL     S C   +D   Y+ +C  DLC  +D 
Sbjct: 249 QDPVPEPPRNCSTG-------FGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDT 301

Query: 297 ETY---CRAATEYARACSHAGYPIQDWRD-DFPACTDKCDDSFVHRDCISCCPPTCTFEK 352
           +     C    EY+R C+HAG   QDWR  DF  C  KC ++  + +C S C  TC+ ++
Sbjct: 302 DLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDF--CPQKCPNNMQYHECRSPCADTCSNQE 359

Query: 353 QCLGSNLHCLDGCYCPDGLVMDN---GTCISLENCPCGFHGLAYSVGSKIEQECTECVCV 409
                  HC+ GC+CP+G V+D+     C+ +  C C ++G AY+ G+    +CT C C 
Sbjct: 360 HSRACEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAPGATYSTDCTNCTCS 419

Query: 410 GGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCE 469
           GG W+C E  CP  CSV+G +HF+TFDG+ Y+  G C Y+L K      FT+  +   C 
Sbjct: 420 GGRWSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCG 479

Query: 470 QNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI----VEIQTLSSLFIL 525
                 CL+S+TL L D     V +   G++    NQ +    I    V I   S+ FI+
Sbjct: 480 LTDSETCLKSVTLSL-DGAQTVVVIKASGEVFL--NQIYTQLPISAANVTIFRPSTFFII 536

Query: 526 LKTTFGLKI-LFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLH 584
            +T+ GL++ L  +   ++++QL    + +T GLCG FN    DDF + SG++E T    
Sbjct: 537 AQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGVVEATAAAF 596

Query: 585 ANAWRVSSTCFAPVHVPVVDPCNINQQN 612
            N ++  + C   +     DPC+++ +N
Sbjct: 597 FNTFKTQAAC-PNIRNSFEDPCSLSVEN 623



 Score =  196 bits (499), Expect = 2e-49
 Identities = 164/571 (28%), Positives = 226/571 (39%), Gaps = 101/571 (17%)

Query: 331  CDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMD-NGTCISLENCPCGFH 389
            C +S        C     T +  C  +  HC+ GC CP GLV D +G CI+ E+CPC  +
Sbjct: 1462 CSNSSAGTPGAECLRSCHTLDVGCFST--HCVSGCVCPPGLVSDGSGGCIAEEDCPCVHN 1519

Query: 390  GLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYI 449
               Y  G  I  +C  C C    W C+ + C   C   GD HF TFDG  YSF G C+YI
Sbjct: 1520 EATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYI 1579

Query: 450  LVK-----GTGKDKFTITLQKAPC------------------------------------ 468
            L +      T    F I  +  PC                                    
Sbjct: 1580 LAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTPDPAANEPAPR 1639

Query: 469  EQNLG----LVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFI 524
            E ++G    L  LQS  LIL++   K V  G GG     P       GI           
Sbjct: 1640 EASVGFRQRLPPLQSYELILQEGTFKAVARGPGGD----PPYKIRYMGI----------F 1685

Query: 525  LLKTTFGLKILFAIDGER---IYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTP 581
            L+  T G+    A+  +R   ++I+L   +K R  GLCG F+ N  +DF + S  + G  
Sbjct: 1686 LVIETHGM----AVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGDA 1741

Query: 582  QLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYA-AHCDVIHQELFAPCHIYISPGLYY 640
                N+W++S +C  P  +   DPC  N     +A   C ++H   FA C   +    YY
Sbjct: 1742 LEFGNSWKLSPSC--PDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACRSQVDSTKYY 1799

Query: 641  QLCRHDACKCGS----SCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-----QKGML 691
            + C +DAC C S     C C A+A YA  C   G+ + +RT    C + C       G  
Sbjct: 1800 EACVNDACACDSGGDCECFCTAVAAYAQACHDAGLCVSWRTP-DTCPLFCDFYNPHGGCE 1858

Query: 692  YHH--CSSFCLHSCISLSSPEQCSDDCAEGC--NCPEGK-FYEDTLNFCVPIFHCRCHYR 746
            +H+  C + CL +C + S          EGC   CP  + F+ +    CV    C C+ +
Sbjct: 1859 WHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKCPPSQPFFNEDQMKCVA--QCGCYDK 1916

Query: 747  -GSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGV 805
             G+ Y  G  +PT    CQ  N         TPS +  C    E   C + D       V
Sbjct: 1917 DGNYYDVGARVPTAEN-CQSCN--------CTPSGIQ-CAHSLEACTCTYEDRTYSYQDV 1966

Query: 806  NCETTCA-NLAMNFTCTPSSPCISGCVCAPG 835
               TT      +   C  +   I   V  PG
Sbjct: 1967 IYNTTDGLGACLIAICGSNGTIIRKAVACPG 1997



 Score =  162 bits (409), Expect = 5e-39
 Identities = 116/396 (29%), Positives = 180/396 (45%), Gaps = 42/396 (10%)

Query: 424 CSVVGDSHFTTFDGRHYSFIGMCQYILVK--GTGKDKFTITLQKAP--CEQNLGLVCLQS 479
           CS  G  H+ TFDG  + F G+C Y+  +  G   + F I L+++       L  V ++ 
Sbjct: 81  CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPTLSRVLMKV 140

Query: 480 ITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAID 539
             ++++    K   L  G  +L      F+ +G++  Q  SS +  ++   GL +++  D
Sbjct: 141 DGVVIQ--LTKGSVLVNGHPVLLP----FSQSGVLIQQ--SSSYTKVEARLGLVLMWNHD 192

Query: 540 GERIYIQLTSAWKRRTLGLCGTFNGN-IRDDFLSPSGMIEGTPQLHANAWRV---SSTCF 595
            + + ++L + +  +T GLCG FNG  +  + LS +  +  TP    N  ++   +  C 
Sbjct: 193 -DSLLLELDTKYANKTCGLCGDFNGMPVVSELLSHNTKL--TPMEFGNLQKMDDPTEQCQ 249

Query: 596 APVHVPVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGS--- 652
            PV  P   P N +    G+    +++H +LF+ C   +  G Y + CR D C C     
Sbjct: 250 DPVPEP---PRNCST---GFGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDL 303

Query: 653 -SCLCNALAHYAYLCGQHG-VPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPE 710
            SC+C+ LA Y+  C   G +P D+R    FC   C   M YH C S C  +C +     
Sbjct: 304 LSCVCHTLAEYSRQCTHAGGLPQDWRGP-DFCPQKCPNNMQYHECRSPCADTCSNQEHSR 362

Query: 711 QCSDDCAEGCNCPEGKFYEDT-LNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGT 769
            C D C  GC CPEG   +D     CVP+  C C Y G+ Y PG    T    C CS G 
Sbjct: 363 ACEDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACVYNGAAYAPGATYSTDCTNCTCSGGR 422

Query: 770 VKCDELATPSAVHICP-------EGKEYF---DCRF 795
             C E+  P    +         +GK+Y    DC +
Sbjct: 423 WSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSY 458



 Score =  141 bits (355), Expect = 8e-33
 Identities = 127/435 (29%), Positives = 179/435 (41%), Gaps = 77/435 (17%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKD-CGD--LEPRYTVWVHNSPKCLGSVYSC 118
            G C  +G  HF TFDG  Y F G+C YI A+D CGD      + +   N P C  +  +C
Sbjct: 1552 GTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFRIVTENIP-CGTTGTTC 1610

Query: 119  YRSISLFFSNQEEIRIYGHEIKKN---------GISLTLP--QTIGQIFIE--------- 158
             ++I LF   +    +   +   N         G    LP  Q+   I  E         
Sbjct: 1611 SKAIKLFVEVRTAPAVSTPDPAANEPAPREASVGFRQRLPPLQSYELILQEGTFKAVARG 1670

Query: 159  ---------KLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDF 209
                     +     LV  T G +++WD  + ++++L +D+KG+ CGLCGN++D   +DF
Sbjct: 1671 PGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDF 1730

Query: 210  IILQEDYTEDIAMFANSW--SVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQ 267
                     D   F NSW  S   PD     L P D   PC++          +C IL  
Sbjct: 1731 ATRSRSVVGDALEFGNSWKLSPSCPD----ALAPKD---PCTANPFRKSWAQKQCSILHG 1783

Query: 268  FPFLSCHEYIDPYLYIASCVNDLCKTD---DDETYCRAATEYARACSHAGYPIQDWRDDF 324
              F +C   +D   Y  +CVND C  D   D E +C A   YA+AC  AG  +  WR   
Sbjct: 1784 PTFAACRSQVDSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHDAGLCV-SWRTP- 1841

Query: 325  PACTDKCDDSFVHRDC---ISCCPPTCTFEKQCLGSNLHC------LDGCY--CPDGLVM 373
              C   CD    H  C      C   C   K C   + HC      L+GCY  CP     
Sbjct: 1842 DTCPLFCDFYNPHGGCEWHYQPCGAPCL--KTCRNPSGHCLVDLPGLEGCYPKCPPSQPF 1899

Query: 374  ---DNGTCISLENCPC-GFHGLAYSVGSKI--EQECTECVCVGGVWNCTEQDCPVQCSVV 427
               D   C++   C C    G  Y VG+++   + C  C       NCT     +QC+  
Sbjct: 1900 FNEDQMKCVA--QCGCYDKDGNYYDVGARVPTAENCQSC-------NCTPSG--IQCAHS 1948

Query: 428  GDSHFTTFDGRHYSF 442
             ++   T++ R YS+
Sbjct: 1949 LEACTCTYEDRTYSY 1963



 Score =  126 bits (316), Expect = 3e-28
 Identities = 166/705 (23%), Positives = 250/705 (35%), Gaps = 133/705 (18%)

Query: 1409 PKDVEMPDCGFRGRPVQVN--SDICCPEWECPCRC-------------SMLSELSIITFD 1453
            PK V    C  +  P++V+  S  C   +EC C C             SM       TFD
Sbjct: 5363 PKPVANVTCVNKHLPIKVSDPSQPCDFHYECECECVGGRGITPGAGICSMWGGSHYSTFD 5422

Query: 1454 GNNAALYSMASYILVRIP----GEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKI 1509
            G +       +Y+L+R      G + +          A +   +  C + L++      I
Sbjct: 5423 GTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAAAARCPRALSIHYKSMDI 5482

Query: 1510 I--VNRLARKVE----VDSIVVPLPFSSQELSIEDSGS--MYVITTPAGLIIKWSHLTGI 1561
            +  V  +  K E     D I V   FS   + +   G+  M V     G+ + ++     
Sbjct: 5483 VLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFNGQVFQ 5542

Query: 1562 IDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE-- 1619
              + +    N    TEG CG C  +  DD   ++GT   + +D+    ++W +  S +  
Sbjct: 5543 ARLPYSLFHN---NTEGQCGTCTNNQRDDCLQRDGTTAASCKDMA---KTWLVPDSRKDG 5596

Query: 1620 ----------VTMRRPVRNC-TEHDC--SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINY 1666
                       +   PV +  T   C      DL+  ++F  CH+ V P  F      ++
Sbjct: 5597 CWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDH 5656

Query: 1667 TYF-WNYECDALSAYVALCNKFDICIQWR--TPDYCSLSCPEGKEYQPCVRPCEARTCLN 1723
                    C +L AY  LC    +C  WR  T   C L+CP  K Y+PC  P +  TC +
Sbjct: 5657 CRGRLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTCPPTKVYKPC-GPIQPATCNS 5715

Query: 1724 QWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDE 1783
            +          + E C C    IL   H   C+  + C C   +  P+  GE W      
Sbjct: 5716 R--NQSPQLEGMAEGCFCPEDQILFNAHMGICV--QACPCVGPDGFPKFPGERWVSNCQS 5771

Query: 1784 CTLYKCLENGSIIPIEPDCDEEPTPVCEREAEV-VMGIIDKWTCCSKEVCGCDTTLCETS 1842
            C   +   +    P+  D   +P P C R   V V     +  CC + VC C+TT C  S
Sbjct: 5772 CVCDEGSVSVQCKPLPCDAQGQPPP-CNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQS 5830

Query: 1843 IPTCTNSQKLIVGHSPLSCCPQYKCE----------------------CDPLKCPSISTP 1880
            +P C   Q+ I       CCP ++C                       C    C S  T 
Sbjct: 5831 LPVCPPGQESICTQEEGDCCPTFRCRPQLCSYNGTFYGVGATFPGALPCHMCTCLSGDTQ 5890

Query: 1881 ----ECRED--------QFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVD---L 1925
                +C+ED        Q     R    CC    CV  +C  P     DG+ + ++   +
Sbjct: 5891 DPTVQCQEDACNNTTCPQGFEYKRVAGQCCGE--CVQTACLTP-----DGQPVQLNETWV 5943

Query: 1926 NSTHFCCPQYYCVCEPN---LCPMP------------------LLNCAEDMNLVKENVSG 1964
            NS    C  Y C  E     L P P                    +C ED   V+ N + 
Sbjct: 5944 NSHVDNCTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCCYSCEEDSCQVRINTT- 6002

Query: 1965 QCCPTWHCECNCENLVMPTCE-----VGEFTAIDHNFQSDCGCIQ 2004
                 WH  C  E + +  CE       +++A     Q  C C Q
Sbjct: 6003 ---ILWHQGCETE-VNITFCEGSCPGASKYSAEAQAMQHQCTCCQ 6043



 Score =  124 bits (312), Expect = 8e-28
 Identities = 164/648 (25%), Positives = 245/648 (37%), Gaps = 100/648 (15%)

Query: 309  ACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCP-PTCTFEKQCLGSNLHCLDGCYC 367
            AC  +  P+       P+    CD++   R          CT  + C+G N   L     
Sbjct: 5307 ACPTSPPPVSSAPLSSPSPAPGCDNAIPLRQVNETWTLENCTVAR-CVGDNRVVL----- 5360

Query: 368  PDGLVMDNGTCISLE--------NCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQD 419
             D   + N TC++          + PC FH            EC EC CVGG        
Sbjct: 5361 LDPKPVANVTCVNKHLPIKVSDPSQPCDFH-----------YEC-ECECVGGRGITPGAG 5408

Query: 420  CPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGK--DKFTITLQKAPCEQNLGLV-- 475
                CS+ G SH++TFDG  Y+F G C Y+L++         ++ L    C  +      
Sbjct: 5409 I---CSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAA 5465

Query: 476  ---CLQSITLILED-DFNKQVTLGRG---GQILTSP---NQGFNLNGIVEIQTLSSLFIL 525
               C +++++  +  D    VT+  G   G IL      + GF+ NG++     ++   +
Sbjct: 5466 AARCPRALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRV 5525

Query: 526  LKTTFGLKILFAIDGERIYIQLT-SAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLH 584
                 G+ + F  +G+    +L  S +   T G CGT   N RDD L   G    + +  
Sbjct: 5526 DIPALGVSVTF--NGQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDM 5583

Query: 585  ANAWRVSST----CFAPVHVPVV-----------DPCNINQQNIGYAAHCDVIHQELFAP 629
            A  W V  +    C+AP   P              P     Q +     CD++  ++FA 
Sbjct: 5584 AKTWLVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPL-----CDLMLSQVFAE 5638

Query: 630  CHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQI-SFCAVVCQK 688
            CH  + PG ++  C  D C+      C +L  YA LC   GV  D+R      C + C  
Sbjct: 5639 CHNLVPPGPFFNACISDHCRGRLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTCPP 5698

Query: 689  GMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGK-FYEDTLNFCVPIFHCRCHYRG 747
              +Y  C      +C S +   Q  +  AEGC CPE +  +   +  CV    C     G
Sbjct: 5699 TKVYKPCGPIQPATCNSRNQSPQL-EGMAEGCFCPEDQILFNAHMGICVQACPC-VGPDG 5756

Query: 748  SVYQPGELIPTPSGLCQCSNG--TVKCDELATPSAVHICPEGKEYFDC----RFPDPELP 801
                PGE   +    C C  G  +V+C  L   +     P  +  F      R  +P  P
Sbjct: 5757 FPKFPGERWVSNCQSCVCDEGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCP 5816

Query: 802  AGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG---VCRRGMFNC--TYYPCPAVCTIY 856
                 C TT        TC  S P     VC PG   +C +   +C  T+   P +C+  
Sbjct: 5817 ETVCVCNTT--------TCPQSLP-----VCPPGQESICTQEEGDCCPTFRCRPQLCSYN 5863

Query: 857  GDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVC 904
            G   +Y   G  +     C +    S D  D +V  Q   C  N+  C
Sbjct: 5864 GT--FYGV-GATFPGALPCHMCTCLSGDTQDPTVQCQEDAC--NNTTC 5906



 Score =  105 bits (261), Expect = 7e-22
 Identities = 89/349 (25%), Positives = 136/349 (38%), Gaps = 68/349 (19%)

Query: 1905 CESCTKPVPLCHDGEFLTVDL-NSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVS 1963
            C++  +P P C+   F+TV    + + CCP+  CVC    CP  L  C      +     
Sbjct: 5788 CDAQGQPPP-CNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPVCPPGQESICTQEE 5846

Query: 1964 GQCCPTWHCECNCENLVMPTCEV-GEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLN 2022
            G CCPT+ C           C   G F  +   F     C    C   D          +
Sbjct: 5847 GDCCPTFRCRPQL-------CSYNGTFYGVGATFPGALPCHMCTCLSGDT--------QD 5891

Query: 2023 PGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCG 2082
            P              T++C E+  N+T           C +  +  +V         CCG
Sbjct: 5892 P--------------TVQCQEDACNNT----------TCPQGFEYKRVAGQ------CCG 5921

Query: 2083 TCKNVSCKFHMENGTSVVYAVGSTW---HY-NCTTYECVKTDEGAIILNYTMVCPPFNET 2138
             C   +C     +G  V   +  TW   H  NCT Y C       ++      CP  + +
Sbjct: 5922 ECVQTACL--TPDGQPV--QLNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCP--DVS 5975

Query: 2139 ECKMNEGIVKLYNEGCCKICKREERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSAT 2198
             C+ +     L   GCC  C  EE  CQ  I  +++  Q C  ++ +N+  C+G CP A+
Sbjct: 5976 SCRGS-----LRKTGCCYSC--EEDSCQVRINTTILWHQGC--ETEVNITFCEGSCPGAS 6026

Query: 2199 IYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTC 2247
             Y+   ++    C CC+E  V   +VPL+C  NG+ I++T    +   C
Sbjct: 6027 KYSAEAQAMQHQCTCCQERRVHEETVPLHCP-NGSAILHTYTHAVQVLC 6074



 Score =  102 bits (253), Expect = 6e-21
 Identities = 103/401 (25%), Positives = 161/401 (40%), Gaps = 50/401 (12%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHN-----SPKCLGSVY 116
            GIC  WG  H+ TFDG  Y F GNC+Y+  ++        ++++ N     S     +  
Sbjct: 5408 GICSMWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAAAA 5467

Query: 117  SCYRSISLFFSNQEEI----RIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTT--- 169
             C R++S+ + + + +     ++G   K+ G+ L     +   F +      ++ TT   
Sbjct: 5468 RCPRALSIHYKSMDIVLTVTMVHG---KEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMR 5524

Query: 170  -----FGFSLAWDG-ISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAM- 222
                  G S+ ++G +    L  S  H     G CG   + Q DD   LQ D T   +  
Sbjct: 5525 VDIPALGVSVTFNGQVFQARLPYSLFHNNTE-GQCGTCTNNQRDD--CLQRDGTTAASCK 5581

Query: 223  -FANSWSVQTPDDTK-CVLTPSDFPNPCSSGMPAFEAIFFK-------CQILLQFPFLSC 273
              A +W V  PD  K     P+  P   S   P               C ++L   F  C
Sbjct: 5582 DMAKTWLV--PDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAEC 5639

Query: 274  HEYIDPYLYIASCVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPA-CTDKCD 332
            H  + P  +  +C++D C+    E  C++   YA  C   G    DWR      C   C 
Sbjct: 5640 HNLVPPGPFFNACISDHCR-GRLEVPCQSLEAYAELCRARGV-CSDWRGATGGLCDLTCP 5697

Query: 333  DSFVHRDCISCCPPTCTFEKQCLGSNLHCL-DGCYCPDGLVMDN---GTCISLENCPC-G 387
             + V++ C    P TC    Q     L  + +GC+CP+  ++ N   G C+  + CPC G
Sbjct: 5698 PTKVYKPCGPIQPATCNSRNQ--SPQLEGMAEGCFCPEDQILFNAHMGICV--QACPCVG 5753

Query: 388  FHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVG 428
              G     G +    C  CVC  G  + + Q  P+ C   G
Sbjct: 5754 PDGFPKFPGERWVSNCQSCVCDEG--SVSVQCKPLPCDAQG 5792



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 98/429 (22%), Positives = 156/429 (36%), Gaps = 48/429 (11%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPG---EIIVAHIEKCSMNQAPSGRISGLCF 1497
            CS        TFDG+      + +Y+     G   E     + +   + AP+  +S +  
Sbjct: 81   CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPT--LSRVLM 138

Query: 1498 KKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSH 1557
            K       +  +++      V V+   V LPFS   + I+ S S   +    GL++ W+H
Sbjct: 139  K-------VDGVVIQLTKGSVLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGLVLMWNH 191

Query: 1558 LTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKS 1617
               ++          ++ T GLCG  N  P     + + T +T ME  G   +  +  + 
Sbjct: 192  DDSLL---LELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPME-FGNLQKMDDPTEQ 247

Query: 1618 FEVTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKM-----WINYTYFWNY 1672
             +  +  P RNC+      C +LL+ ++F  C   V    + E       +   T   + 
Sbjct: 248  CQDPVPEPPRNCST-GFGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDLLSC 306

Query: 1673 ECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTS 1731
             C  L+ Y   C       Q WR PD+C   CP   +Y  C  PC A TC NQ  +    
Sbjct: 307  VCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPC-ADTCSNQ-EHSRAC 364

Query: 1732 CLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTL----Y 1787
              +    C C  GT+L       C+P  +CAC          G  ++     CT     +
Sbjct: 365  EDHCVAGCFCPEGTVLDDIGQTGCVPVSKCACV-YNGAAYAPGATYSTDCTNCTCSGGRW 423

Query: 1788 KCLE------------------NGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSK 1829
             C E                  +G    +  DC    T  C+  A  V+  + +      
Sbjct: 424  SCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCGLTDS 483

Query: 1830 EVCGCDTTL 1838
            E C    TL
Sbjct: 484  ETCLKSVTL 492



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 64/276 (23%), Positives = 105/276 (38%), Gaps = 68/276 (24%)

Query: 784  CPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVC----------- 832
            CP   +Y +CR P          C  TC+N   +  C     C++GC C           
Sbjct: 338  CPNNMQYHECRSP----------CADTCSNQEHSRAC--EDHCVAGCFCPEGTVLDDIGQ 385

Query: 833  ------------------APGV----------CRRGMFNCTYYPCPAVCTIYGDRHYYSF 864
                              APG           C  G ++C   PCP  C++ G  H+ +F
Sbjct: 386  TGCVPVSKCACVYNGAAYAPGATYSTDCTNCTCSGGRWSCQEVPCPGTCSVLGGAHFSTF 445

Query: 865  DGLEYDYISDCQVFLIKSADDSDISVIAQNKKC-FDNDIVCSKSVLISVGDTEIYLNDTP 923
            DG +Y    DC   L K  D S  +V+A+ ++C   +   C KSV +S+   +     T 
Sbjct: 446  DGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCGLTDSETCLKSVTLSLDGAQ-----TV 500

Query: 924  YKQKQSGFFLENKSTYQLWKAGYYIVVYFPEK-----------DITILWDRKTTIHIKVG 972
               K SG    N+   QL  +   + ++ P              + +       + +++ 
Sbjct: 501  VVIKASGEVFLNQIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLA 560

Query: 973  PQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVF 1008
            P+ + +  GLCGNF+   ++D  T + +    A  F
Sbjct: 561  PKLRGQTCGLCGNFNSIQADDFRTLSGVVEATAAAF 596



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 61/278 (21%), Positives = 116/278 (41%), Gaps = 37/278 (13%)

Query: 852  VCTIYGDRHYYSFDGLEYDYISDCQVFLIKSA----DDSDISVIAQNKKC---FDNDIVC 904
            VC+ +G  HY +FDG  + +   C     +      +D +I +    +         ++ 
Sbjct: 80   VCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDFNIQLRRSQESAAPTLSRVLMK 139

Query: 905  SKSVLISVGDTEIYLNDTPYKQ--KQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWD 962
               V+I +    + +N  P      QSG  ++  S+Y   +A   +V         ++W+
Sbjct: 140  VDGVVIQLTKGSVLVNGHPVLLPFSQSGVLIQQSSSYTKVEARLGLV---------LMWN 190

Query: 963  RKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDE 1022
               ++ +++  ++ NK  GLCG+F     N M   + L   N ++       G  +  D+
Sbjct: 191  HDDSLLLELDTKYANKTCGLCGDF-----NGMPVVSELLSHNTKL--TPMEFGNLQKMDD 243

Query: 1023 TIKPCEAHQNKFPYAKKECS--------ILYSDIFASCRNVIDVTSFAKNCHEDTCNCNL 1074
              + C   Q+  P   + CS        +L+  +F+ C  ++DV S+ + C +D C C  
Sbjct: 244  PTEQC---QDPVPEPPRNCSTGFGICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCED 300

Query: 1075 GGDCECLCTSIAAYAYKCCQE-GISIHWRSSTVCSLDC 1111
                 C+C ++A Y+ +C    G+   WR    C   C
Sbjct: 301  TDLLSCVCHTLAEYSRQCTHAGGLPQDWRGPDFCPQKC 338



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 138/641 (21%), Positives = 216/641 (33%), Gaps = 151/641 (23%)

Query: 1421 GRPVQVNSDICC---PEWECPCR-----CSMLSELSIITFDGNNAALYSMASYILVR-IP 1471
            G  ++V+ + C      WEC  R     C    +   ITFDG+  +      YIL +   
Sbjct: 1526 GETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYC 1585

Query: 1472 GEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKI--------IVNRLA-RKVEVDS 1522
            G+       +      P G     C K + +   +             N  A R+  V  
Sbjct: 1586 GDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVEVRTAPAVSTPDPAANEPAPREASVGF 1645

Query: 1523 IVVPLPFSSQELSIEDSG-------------------SMYVITTPAGLIIKWSHLTGI-I 1562
                 P  S EL +++                      ++++    G+ + W   T + I
Sbjct: 1646 RQRLPPLQSYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFI 1705

Query: 1563 DIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM 1622
             +H  ++  +     GLCG  +++  +D   ++ +++ +  + G    SW++  S    +
Sbjct: 1706 RLHQDYKGRVC----GLCGNFDDNAINDFATRSRSVVGDALEFG---NSWKLSPSCPDAL 1758

Query: 1623 RRPVRNCTEHDC------SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE--- 1673
              P   CT +         QC  +L+   F  C  +V    + E   +N     +     
Sbjct: 1759 -APKDPCTANPFRKSWAQKQC-SILHGPTFAACRSQVDSTKYYEAC-VNDACACDSGGDC 1815

Query: 1674 ---CDALSAYVALCNKFDICIQWRTPDYCSLSC----PEGK---EYQPCVRPCEARTCLN 1723
               C A++AY   C+   +C+ WRTPD C L C    P G     YQPC  PC  +TC N
Sbjct: 1816 ECFCTAVAAYAQACHDAGLCVSWRTPDTCPLFCDFYNPHGGCEWHYQPCGAPC-LKTCRN 1874

Query: 1724 QWFY------GHTSCLN--------LRED---CVCKVG---------------TILHRPH 1751
               +      G   C            ED   CV + G                      
Sbjct: 1875 PSGHCLVDLPGLEGCYPKCPPSQPFFNEDQMKCVAQCGCYDKDGNYYDVGARVPTAENCQ 1934

Query: 1752 SAQCIPE--------KECACTDSEDQPRTAGEIWN--GGIDECTLYKCLENGSIIPIEPD 1801
            S  C P         + C CT  +        I+N   G+  C +  C  NG+II     
Sbjct: 1935 SCNCTPSGIQCAHSLEACTCTYEDRTYSYQDVIYNTTDGLGACLIAICGSNGTIIRKAVA 1994

Query: 1802 CDEEP--TPVCEREAEV----VMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVG 1855
            C   P  TP     A V        +   T C +EVC                      G
Sbjct: 1995 CPGTPATTPFTFTTAWVPHSTTSPALPVSTVCVREVC---------------RWSSWYNG 2039

Query: 1856 HSPLSCCPQYKCEC-DPLK------CPSISTPECREDQF----MIQVRQEEPCCFSPFCV 1904
            H P         E  + L+      CP ++  ECR  Q     + ++ Q+  C      +
Sbjct: 2040 HRPEPGLGGGDFETFENLRQRGYQVCPVLADIECRAAQLPDMPLEELGQQVDCDRMRGLM 2099

Query: 1905 CESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNLCP 1945
            C +  +  PLCHD E   +       CC   Y  C P+  P
Sbjct: 2100 CANSQQSPPLCHDYELRVL-------CCE--YVPCGPSPAP 2131



 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 80/340 (23%), Positives = 127/340 (37%), Gaps = 51/340 (15%)

Query: 810  TCANLAMNFTCT-PSSPCI----SGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSF 864
            TC N  +    + PS PC       C C  G   RG+      P   +C+++G  HY +F
Sbjct: 5370 TCVNKHLPIKVSDPSQPCDFHYECECECVGG---RGIT-----PGAGICSMWGGSHYSTF 5421

Query: 865  DGLEYDYISDCQVFLIKS--ADDSDISVIAQNKKCFDNDIV------CSKSVLISVGDTE 916
            DG  Y +  +C   L++   A   ++S+   N  C  +         C +++ I     +
Sbjct: 5422 DGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAAAARCPRALSIHYKSMD 5481

Query: 917  IYLNDTPYKQKQSGFFLENKSTYQ--LWKAGYYIVVY--------FPEKDITILWDRKTT 966
            I L  T    K+ G  L ++        K G  + V          P   +++ ++ +  
Sbjct: 5482 IVLTVTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFNGQVF 5541

Query: 967  IHIKVGPQWKNKLSGLCGNF-----DKCTSNDMTTSNNLE-------VRNARVFGDSWAL 1014
                    + N   G CG       D C   D TT+ + +       V ++R  G  WA 
Sbjct: 5542 QARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVPDSRKDG-CWAP 5600

Query: 1015 GQCESPDETIKPCEAHQNKFPYAKKE-CSILYSDIFASCRNVIDVTSFAKNCHEDTCNCN 1073
                       P  +     P   +  C ++ S +FA C N++    F   C  D C   
Sbjct: 5601 TGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDHCR-- 5658

Query: 1074 LGGDCECLCTSIAAYAYKCCQEGISIHWRSST--VCSLDC 1111
              G  E  C S+ AYA  C   G+   WR +T  +C L C
Sbjct: 5659 --GRLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTC 5696



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 102/463 (22%), Positives = 173/463 (37%), Gaps = 46/463 (9%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGE---IIVAHIEKCSMNQAP 1488
            C +  CP  CS+     I T+D     L+   SY+L +   +    ++A + KC +    
Sbjct: 1075 CQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYVLSKKCADSSFTVLAELRKCGLTDNE 1134

Query: 1489 SGRISGLCFKKLNVTTPIHKIIVNRLA-RKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
            +      C K + ++       +   A   V ++SI   LP S+  +++    S +++  
Sbjct: 1135 N------CLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQLPLSAANITLFTPSSFFIVVQ 1188

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG- 1606
                +     L  ++ +             GLCG  N++  DD    +G +    E  G 
Sbjct: 1189 TGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFNQNQADDFTALSGVV----EATGA 1244

Query: 1607 LFIESWEIE-------KSFEVTMRRPV--RNCTEHDCSQCIDLLNRRIFIPCHDKVSPED 1657
             F  +W+ +        SFE      V   N   H CS+  D      F  CH  ++P+ 
Sbjct: 1245 AFANTWKAQAACANARNSFEDPCSLSVENENYARHWCSRLTD--PNSAFSRCHSIINPKP 1302

Query: 1658 F---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCS---LSCPEGKEYQP 1711
            F   C     N     +  C ALS+YV  C    + +       C+    +CP+ + Y  
Sbjct: 1303 FHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQRYAY 1362

Query: 1712 CVRPCEARTCLNQWFYGHTSCLNL--REDCVCKVGTILHRPHSAQCIPEKECACTDSEDQ 1769
             V  C+  TC        T  ++    + C C  GT L+   +  C+P +EC C  +   
Sbjct: 1363 VVDACQP-TCRGLSEADVTCSVSFVPVDGCTCPAGTFLN--DAGACVPAQECPCY-AHGT 1418

Query: 1770 PRTAGEIWN--GGIDECTLYKCLENGSIIPIEPDCDEEPTPV-CEREAEVVMGIIDKWTC 1826
                GE+ +  G +  CT  K    G+ +     C      + C   +    G     +C
Sbjct: 1419 VLAPGEVVHDEGAVCSCTGGKLSCLGASLQKSTGCAAPMVYLDCSNSSAGTPGAECLRSC 1478

Query: 1827 CSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCEC 1869
             + +V GC +T C   +  C     L+   S   C  +  C C
Sbjct: 1479 HTLDV-GCFSTHC---VSGCVCPPGLVSDGSG-GCIAEEDCPC 1516



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 25/57 (43%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDC 1332
            CEW Y+PC  PC KTC +P       LP +EGC P CP +    +E  +KCV    C
Sbjct: 1857 CEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKCPPSQPFFNEDQMKCVAQCGC 1913



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 42/172 (24%), Positives = 73/172 (42%), Gaps = 12/172 (6%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVR---IPGEIIVAHIEKCSMNQAP 1488
            C E  CP  CS+L      TFDG    ++   SY+L +        ++A + +C +    
Sbjct: 425  CQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAFTVLAELRRCGLTD-- 482

Query: 1489 SGRISGLCFKKLNVTTP-IHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVIT- 1546
                S  C K + ++      ++V + + +V ++ I   LP S+  ++I    + ++I  
Sbjct: 483  ----SETCLKSVTLSLDGAQTVVVIKASGEVFLNQIYTQLPISAANVTIFRPSTFFIIAQ 538

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTI 1598
            T  GL +    L   + +       L   T GLCG  N    DD R  +G +
Sbjct: 539  TSLGLQLN-LQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGVV 589



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 64/276 (23%), Positives = 105/276 (38%), Gaps = 26/276 (9%)

Query: 1527 LPFSSQELSIEDSGSMYVITTPAGLIIKWS-HLTGIIDIHFGFRFNLSSYTEGLCGICNE 1585
            LP+S   L +E SG    ++    L   W+   + ++++   +    ++ T GLCG  N 
Sbjct: 813  LPYSRTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALLELDPKY----ANQTCGLCGDFNG 868

Query: 1586 DPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI 1645
             P  +    +   +T ++   L       E+  +  +  P  NCT+ +   C   L    
Sbjct: 869  LPAFNEFYAHNARLTPLQFGNLQKLDGPTEQCPD-PLPLPAGNCTDEE-GICHRTLLGPA 926

Query: 1646 FIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALC-NKFDICIQWRTPDYCSLSCP 1704
            F  CH  V    +      +        C     Y   C +       WR P+ C  +CP
Sbjct: 927  FAECHALVDSTAYLAACAQDLCRCPTCPCATFVEYSRQCAHAGGQPRNWRCPELCPRTCP 986

Query: 1705 EGKEYQPCVRPCEARTCLN----QWFYGHTSCLNLREDCVCKVG---TILHRPHSAQCIP 1757
               ++Q C  PC   TC N    Q    H  C+   + C C  G   T+L     + C+P
Sbjct: 987  LNMQHQECGSPC-TDTCSNPQRAQLCEDH--CV---DGCFCPPGRSCTVLDDITHSGCLP 1040

Query: 1758 EKECACTDSEDQPRTAGEIWNGGIDECT----LYKC 1789
              +C CT    +  + G  +N     CT    L++C
Sbjct: 1041 LGQCPCTHG-GRTYSPGTSFNTTCSSCTCSGGLWQC 1075



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 9/57 (15%)

Query: 1280 RYEPCATPCFKTCSDPE-ALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPV 1335
            +Y  C +PC  TCS+ E + AC+    V GC  +CP+  +LD++         C+PV
Sbjct: 343  QYHECRSPCADTCSNQEHSRACED-HCVAGC--FCPEGTVLDDIG-----QTGCVPV 391


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score =  463 bits (1191), Expect = e-130
 Identities = 323/1129 (28%), Positives = 488/1129 (43%), Gaps = 127/1129 (11%)

Query: 64   CKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRSIS 123
            C +W  +H+ TFDG +Y+F G C+Y+ A   G  +  + V +    +C    + C R   
Sbjct: 195  CASWSGFHYRTFDGRHYHFLGRCTYLLA---GAADSTWAVHLTPGDRCPQPGH-CQRVTM 250

Query: 124  LFFSNQEEIRIYGHEIKKNGISLTLPQT--IGQIFIEKLADYILVKTTFGFSLAWDGISG 181
                  EE+ I    +   G  +   Q+  +  + ++ L D++++    G  +  D    
Sbjct: 251  ----GPEEVLIQAGNVSVKGQLVPEGQSWLLHGLSLQWLGDWLVLSGGLGVVVRLDRTGS 306

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTP 241
            I + +  +  G++ GLCG YN    DDF+          A F NSW +  P      L  
Sbjct: 307  ISISVDHELWGQTQGLCGLYNGWPEDDFMEPGGGLAMLAATFGNSWRL--PGSESGCLDA 364

Query: 242  SDFPNPCSS----------GMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLC 291
             +    C            G    EA    C  LL+ PF  CH  + P  Y  +C+   C
Sbjct: 365  VEVAQGCDPLGLIDADVEPGHLRAEAQDV-CHQLLEGPFGQCHAQVSPAEYHEACLFAYC 423

Query: 292  --------KTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISC 343
                    +    +  C     Y +AC+     I+  +  F  C   C    ++ DC+S 
Sbjct: 424  AGAMAGSGQEGRQQAVCATFASYVQACARRHIHIRWRKPGF--CERLCPGGQLYSDCVSL 481

Query: 344  CPPTCTF-----EKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSK 398
            CPP+C       E+ C      C+ GC CP GL  +   C+   +CPC +    Y  G  
Sbjct: 482  CPPSCEAVGQGEEESC---REECVSGCECPRGLFWNGTLCVPAAHCPCYYCRQRYVPGDT 538

Query: 399  IEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGM--CQYILVKGTGK 456
            + Q C  CVC  G W+C +  CP +C+V GD H+ TFDGR YSF G   C+Y LV+   K
Sbjct: 539  VRQLCNPCVCRDGRWHCAQALCPAECAVGGDGHYLTFDGRSYSFWGGQGCRYSLVQDYVK 598

Query: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI--- 513
             +  I L+   C+      CL +I++ LED     + L   G +L +  Q   L  I   
Sbjct: 599  GQLLILLEHGACDAGS---CLHAISVSLEDT---HIQLRDSGAVLVN-GQDVGLPWIGAE 651

Query: 514  -VEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLS 572
             + ++  SS F+LL+   G ++L+ +     YI L      +  GLCGTF  N +DDFL+
Sbjct: 652  GLSVRRASSAFLLLRWP-GAQVLWGLSDPVAYITLDPRHAHQVQGLCGTFTQNQQDDFLT 710

Query: 573  PSGMIEGTPQLHANAWRVSSTCFAPVH-VPVVDPCNINQQNIGYA-AHCDVIHQELFAPC 630
            P+G +E +    A+ ++V+     P     ++ PC  + Q   +A A C ++H  +F  C
Sbjct: 711  PAGDVETSIAAFASKFQVAGKGRCPSEDSALLSPCTTHSQRHAFAEAACAILHSSVFQEC 770

Query: 631  HIYISPGLYYQLCRHDACKC--GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQK 688
            H  +    +Y  C    C C  GS CLC  L+ YA  C Q G    +R Q + C V+C  
Sbjct: 771  HRLVDKEPFYLRCLAAVCGCDPGSDCLCPVLSAYARRCAQEGASPPWRNQ-TLCPVMCPG 829

Query: 689  GMLYHHCSSFCLHSCISLSSPEQCSD--DCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYR 746
            G  Y  C+  C   C     PE C +   C  GCNCP G  + D    CVP   C C   
Sbjct: 830  GQEYRECAPACGQHC---GKPEDCGELGSCVAGCNCPLGLLW-DPEGQCVPPSLCPCQLG 885

Query: 747  GSVYQPGELIPTPSGLCQCSN-GTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGV 805
               Y PG         C C   G   C     PS    CP    Y           A G 
Sbjct: 886  ARRYAPGSATMKECNRCICQERGLWNCTARHCPSQA-FCPRELVY-----------APGA 933

Query: 806  NCETTCANLAMNFTCTPSSPCISGCVCAPG------------------------------ 835
             C  TC + + N +C   S    GCVC PG                              
Sbjct: 934  -CLLTCDSPSANHSCPAGST--DGCVCPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQ 990

Query: 836  ------VCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDIS 889
                  VCR   ++CT       C   G  HY +FDGL + Y   C+  L++ A     +
Sbjct: 991  EDCNVCVCRGRQWHCTGQRRSGRCQASGAPHYVTFDGLAFTYPGACEYLLVREASGL-FT 1049

Query: 890  VIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTY-----QLWKA 944
            V AQN  C  + + C+K++ + +  T +++         +G  +     Y      L +A
Sbjct: 1050 VSAQNLPCGASGLTCTKALAVRLEGTVVHML-RGRAVTVNGVSVTPPKVYTGPGLSLRRA 1108

Query: 945  GYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRN 1004
            G ++++      +T+LWD  T + +++ PQ++ +++GLCG+FD   SND+ +   +    
Sbjct: 1109 GLFLLLS-THLGLTLLWDGGTRVLVQLSPQFRGRVAGLCGDFDGDASNDLRSRQGVLEPT 1167

Query: 1005 ARVFGDSWALGQ-CESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAK 1063
            A +   SW L   C  P +   PC  + ++  +A+  C  L   +F  C   +      +
Sbjct: 1168 AELAAHSWRLSPLCPEPGDLPHPCTMNTHRAGWARARCGALLQPLFTLCHAEVPPQQHYE 1227

Query: 1064 NCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCE 1112
             C  D C C+ GGDCECLC++IA YA +C + G  + WRS  +CSL CE
Sbjct: 1228 WCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCE 1276



 Score =  247 bits (631), Expect = 8e-65
 Identities = 162/530 (30%), Positives = 239/530 (45%), Gaps = 57/530 (10%)

Query: 345  PPTCTFEKQCLGSNLHC----LDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIE 400
            P  C        +N  C     DGC CP G V+ +  C+  + CPC   G  Y   + I+
Sbjct: 931  PGACLLTCDSPSANHSCPAGSTDGCVCPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQ 990

Query: 401  QECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFT 460
            ++C  CVC G  W+CT Q    +C   G  H+ TFDG  +++ G C+Y+LV+      FT
Sbjct: 991  EDCNVCVCRGRQWHCTGQRRSGRCQASGAPHYVTFDGLAFTYPGACEYLLVR-EASGLFT 1049

Query: 461  ITLQKAPCEQNLGLVCLQSITLILEDDF-----NKQVTLGRGGQILTSPN----QGFNLN 511
            ++ Q  PC  + GL C +++ + LE         + VT+   G  +T P      G +L 
Sbjct: 1050 VSAQNLPCGAS-GLTCTKALAVRLEGTVVHMLRGRAVTVN--GVSVTPPKVYTGPGLSLR 1106

Query: 512  GIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFL 571
                    + LF+LL T  GL +L+   G R+ +QL+  ++ R  GLCG F+G+  +D  
Sbjct: 1107 R-------AGLFLLLSTHLGLTLLWD-GGTRVLVQLSPQFRGRVAGLCGDFDGDASNDLR 1158

Query: 572  SPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYA-AHCDVIHQELFAPC 630
            S  G++E T +L A++WR+S  C  P  +P   PC +N    G+A A C  + Q LF  C
Sbjct: 1159 SRQGVLEPTAELAAHSWRLSPLCPEPGDLP--HPCTMNTHRAGWARARCGALLQPLFTLC 1216

Query: 631  HIYISPGLYYQLCRHDACKCGSS----CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC 686
            H  + P  +Y+ C +DAC C S     CLC+A+A YA  C +HG  + +R+Q   C++ C
Sbjct: 1217 HAEVPPQQHYEWCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQ-ELCSLQC 1275

Query: 687  QKGMLYHHCSSFCLHSCISLSSPE---QCSD-DCAEGCNCPEGKFYEDTLNFCVPIFHCR 742
            + G +Y  C   C  +C     PE    C    C EGC CPEG         C+    C 
Sbjct: 1276 EGGQVYEACGPTCPPTCHE-QHPEPGWHCQVVACVEGCFCPEGTLLHG--GACLEPASCP 1332

Query: 743  CHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPA 802
            C +  + + PG ++    G C C  G   C              G +   C    P    
Sbjct: 1333 CEWGRNSFPPGSVLQKDCGNCTCQEGQWHC--------------GGDGGHCEELVPACAE 1378

Query: 803  GGVNCETTCANLAMNFTCTPSSPCISGC---VCAPGVCRRGMFNCTYYPC 849
            G   C+     +   + C     C  G     CA   C  G   C+   C
Sbjct: 1379 GEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHC 1428



 Score =  186 bits (473), Expect = 2e-46
 Identities = 105/367 (28%), Positives = 178/367 (48%), Gaps = 19/367 (5%)

Query: 57   GNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVY 116
            G  R G C+  G  H+ TFDG+ + +PG C Y+  ++   L   +TV   N P C  S  
Sbjct: 1007 GQRRSGRCQASGAPHYVTFDGLAFTYPGACEYLLVREASGL---FTVSAQNLP-CGASGL 1062

Query: 117  SCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQ--TIGQIFIEKLADYILVKTTFGFSL 174
            +C +++++         + G  +  NG+S+T P+  T   + + +   ++L+ T  G +L
Sbjct: 1063 TCTKALAVRLEGTVVHMLRGRAVTVNGVSVTPPKVYTGPGLSLRRAGLFLLLSTHLGLTL 1122

Query: 175  AWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDD 234
             WDG + + ++LS   +G+  GLCG+++   S+D    Q        + A+SW +     
Sbjct: 1123 LWDGGTRVLVQLSPQFRGRVAGLCGDFDGDASNDLRSRQGVLEPTAELAAHSWRL----- 1177

Query: 235  TKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTD 294
            +     P D P+PC+           +C  LLQ  F  CH  + P  +   C+ D C  D
Sbjct: 1178 SPLCPEPGDLPHPCTMNTHRAGWARARCGALLQPLFTLCHAEVPPQQHYEWCLYDACGCD 1237

Query: 295  ---DDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFE 351
               D E  C A   YA  C+  G+ ++ WR     C+ +C+   V+  C   CPPTC  +
Sbjct: 1238 SGGDCECLCSAIATYADECARHGHHVR-WRSQ-ELCSLQCEGGQVYEACGPTCPPTCHEQ 1295

Query: 352  KQCLGSNLH---CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVC 408
                G +     C++GC+CP+G ++  G C+   +CPC +   ++  GS ++++C  C C
Sbjct: 1296 HPEPGWHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTC 1355

Query: 409  VGGVWNC 415
              G W+C
Sbjct: 1356 QEGQWHC 1362



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 145/593 (24%), Positives = 215/593 (36%), Gaps = 115/593 (19%)

Query: 1424 VQVNSDICC---PEWECPC-----RCSMLSELSIITFDGNNAALYSMASYILVRIPGEII 1475
            +Q + ++C     +W C       RC        +TFDG          Y+LVR    + 
Sbjct: 989  IQEDCNVCVCRGRQWHCTGQRRSGRCQASGAPHYVTFDGLAFTYPGACEYLLVREASGLF 1048

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRL-ARKVEVDSIVVPLP--FSSQ 1532
                   S    P G     C K L V   +   +V+ L  R V V+ + V  P  ++  
Sbjct: 1049 TV-----SAQNLPCGASGLTCTKALAVR--LEGTVVHMLRGRAVTVNGVSVTPPKVYTGP 1101

Query: 1533 ELSIEDSGSMYVITTPAGLIIKWSHLTGI-IDIHFGFRFNLSSYTEGLCGICNEDPDDDL 1591
             LS+  +G   +++T  GL + W   T + + +   FR  ++    GLCG  + D  +DL
Sbjct: 1102 GLSLRRAGLFLLLSTHLGLTLLWDGGTRVLVQLSPQFRGRVA----GLCGDFDGDASNDL 1157

Query: 1592 RMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS-----------QCIDL 1640
            R + G +    E   L   SW +          P      H C+           +C  L
Sbjct: 1158 RSRQGVLEPTAE---LAAHSWRLSPLC------PEPGDLPHPCTMNTHRAGWARARCGAL 1208

Query: 1641 LNRRIFIPCHDKVSPEDFCEKMWINYTYFW-------NYECDALSAYVALCNKFDICIQW 1693
            L + +F  CH +V P+   E  W  Y              C A++ Y   C +    ++W
Sbjct: 1209 L-QPLFTLCHAEVPPQQHYE--WCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRW 1265

Query: 1694 RTPDYCSLSCPEGKEYQPCVRPCEARTCLNQ-----WFYGHTSCLNLREDCVCKVGTILH 1748
            R+ + CSL C  G+ Y+ C   C   TC  Q     W     +C+   E C C  GT+LH
Sbjct: 1266 RSQELCSLQCEGGQVYEACGPTCPP-TCHEQHPEPGWHCQVVACV---EGCFCPEGTLLH 1321

Query: 1749 -----RPHSAQC-----------IPEKECA-CTDSEDQPRTAGEIWNGG-----IDECTL 1786
                  P S  C           + +K+C  CT  E Q    G+   GG     +  C  
Sbjct: 1322 GGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGD---GGHCEELVPACAE 1378

Query: 1787 YK--CLENGSIIPIEPDCDEEPT--PVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETS 1842
             +  C ENG  +P    CD +       + E     G  +    CS   C     LC+  
Sbjct: 1379 GEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQ 1438

Query: 1843 IPTCTNSQKLIVGHSPLSCCPQYKCECDPLKC--PSI---STPECREDQFMIQVRQEEPC 1897
               C +         P   CPQ    C   +C  P++     P+C      +    EE C
Sbjct: 1439 -DDCGDGT-----DEPSYPCPQGLLACADGRCLPPALLCDGHPDC------LDAADEESC 1486

Query: 1898 CFSPFCVCESCTKPVPLCHDGEFL-TVDLNSTHFCCPQYYCVCEPNLCPMPLL 1949
                 CV    +     C DG  L  + L    + CP       P  CP+P L
Sbjct: 1487 LGQVTCVPGEVS-----CVDGTCLGAIQLCDGVWDCPD-GADEGPGHCPLPSL 1533



 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 35/105 (33%), Positives = 47/105 (44%), Gaps = 7/105 (6%)

Query: 327  CTDKCDDSFVHRDCISC------CPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCIS 380
            CT +C ++ + R    C      CP  C  +   +     C  GC CP GL + N +C+ 
Sbjct: 2882 CTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLP 2941

Query: 381  LENCPCGFHGLAYSVGSKIE-QECTECVCVGGVWNCTEQDCPVQC 424
               CPC  HG  Y+ G+      C  C CV G   CT + CPV C
Sbjct: 2942 RSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVAC 2986



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 84/351 (23%), Positives = 140/351 (39%), Gaps = 42/351 (11%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMAS--YILVR--IPGEIIVAHIEKCSMNQA 1487
            C +  CP  C++  +   +TFDG + + +      Y LV+  + G++++  +E  + +  
Sbjct: 555  CAQALCPAECAVGGDGHYLTFDGRSYSFWGGQGCRYSLVQDYVKGQLLIL-LEHGACD-- 611

Query: 1488 PSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-LSIEDSGSMYVIT 1546
                 +G C   ++V+     I + R +  V V+   V LP+   E LS+  + S +++ 
Sbjct: 612  -----AGSCLHAISVSLEDTHIQL-RDSGAVLVNGQDVGLPWIGAEGLSVRRASSAFLLL 665

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
               G  + W     +  I    R   +   +GLCG   ++  DD     G + T+   I 
Sbjct: 666  RWPGAQVLWGLSDPVAYITLDPRH--AHQVQGLCGTFTQNQQDDFLTPAGDVETS---IA 720

Query: 1607 LFIESWEIE-----KSFEVTMRRPVRNCTEHD-----CSQCIDLLNRRIFIPCHDKVSPE 1656
             F   +++       S +  +  P   CT H            +L+  +F  CH  V  E
Sbjct: 721  AFASKFQVAGKGRCPSEDSALLSP---CTTHSQRHAFAEAACAILHSSVFQECHRLVDKE 777

Query: 1657 DF---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGKEYQPCV 1713
             F   C           +  C  LSAY   C +      WR    C + CP G+EY+ C 
Sbjct: 778  PFYLRCLAAVCGCDPGSDCLCPVLSAYARRCAQEGASPPWRNQTLCPVMCPGGQEYRECA 837

Query: 1714 RPCEARTCLNQWFYGHT-SCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
              C  + C      G   SC+     C C +G +L  P   QC+P   C C
Sbjct: 838  PAC-GQHCGKPEDCGELGSCV---AGCNCPLG-LLWDP-EGQCVPPSLCPC 882



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 27/77 (35%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query: 345  PPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECT 404
            P +C       G+N  C  GC+CP G+++ N  C+  ++CPC   G  Y  GS + + C 
Sbjct: 3103 PASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCE 3162

Query: 405  ECVCVGG-VWNCTEQDC 420
             C CV G + NC+   C
Sbjct: 3163 NCSCVSGLIANCSSWPC 3179



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 86/355 (24%), Positives = 130/355 (36%), Gaps = 55/355 (15%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C+  S     TFDG +       +Y+L          H+        P     G C +  
Sbjct: 195  CASWSGFHYRTFDGRHYHFLGRCTYLLAGAADSTWAVHLTPGDRCPQP-----GHCQR-- 247

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLPFS--SQELSIEDSGSMYVITTPAGLIIKWSHL 1558
             VT    ++++   A  V V   +VP   S     LS++  G   V++   G++++    
Sbjct: 248  -VTMGPEEVLIQ--AGNVSVKGQLVPEGQSWLLHGLSLQWLGDWLVLSGGLGVVVRLDR- 303

Query: 1559 TGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKS- 1617
            TG I I       L   T+GLCG+ N  P+DD     G +       G    SW +  S 
Sbjct: 304  TGSISISVDHE--LWGQTQGLCGLYNGWPEDDFMEPGGGLAMLAATFG---NSWRLPGSE 358

Query: 1618 ------FEVTMRRPVRNCTEHDC------SQCIDLLNRRI---FIPCHDKVSPEDFCEKM 1662
                   EV          + D       ++  D+ ++ +   F  CH +VSP ++ E  
Sbjct: 359  SGCLDAVEVAQGCDPLGLIDADVEPGHLRAEAQDVCHQLLEGPFGQCHAQVSPAEYHEAC 418

Query: 1663 WINYTYF----------WNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGKEYQPC 1712
               Y                 C   ++YV  C +  I I+WR P +C   CP G+ Y  C
Sbjct: 419  LFAYCAGAMAGSGQEGRQQAVCATFASYVQACARRHIHIRWRKPGFCERLCPGGQLYSDC 478

Query: 1713 VRPCEARTCLNQWFYGHTSCLNLREDCV----CKVGTILHRPHSAQCIPEKECAC 1763
            V  C   +C         SC   RE+CV    C  G      +   C+P   C C
Sbjct: 479  VSLCPP-SCEAVGQGEEESC---REECVSGCECPRGLFW---NGTLCVPAAHCPC 526



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 11/87 (12%)

Query: 344  CPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPC------GFHGLAYSVGS 397
            CPP+C   K     + HC++GC CP GL++ +  C+ L  CPC       + G+++ +G+
Sbjct: 2635 CPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGN 2694

Query: 398  KIEQECTECVCVGGVWNCTEQDCPVQC 424
                 C++CVC  G   C    CP+ C
Sbjct: 2695 -----CSQCVCEKGELLCQPGGCPLPC 2716



 Score = 65.1 bits (157), Expect = 8e-10
 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 14/107 (13%)

Query: 330  KCDDSFVHRDCISCCPPTCT-FEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGF 388
            +C    V   C + CP  C   +   +     C  GC CP G ++ NGTC+    CPC  
Sbjct: 4817 ECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTACPCTQ 4876

Query: 389  HGLAYSV-------------GSKIEQECTECVCVGGVWNCTEQDCPV 422
            H L + +             G+ + + CT CVC GG ++C+  DC V
Sbjct: 4877 HSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLVDCQV 4923



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 34/104 (32%), Positives = 42/104 (40%), Gaps = 5/104 (4%)

Query: 682  CAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDD--CAEGCNCPEGKFYEDTLNFCVPIF 739
            C   C  GM    C++ C   C  L     C DD  C +GC CP+G   +D    CVPI 
Sbjct: 4058 CEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQD--GGCVPIG 4115

Query: 740  HCRC-HYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVH 782
            HC C   +G  + PG         C C  G + C     P   H
Sbjct: 4116 HCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTH 4159



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 60/235 (25%), Positives = 78/235 (33%), Gaps = 69/235 (29%)

Query: 686  CQKGMLYHHCSSFCLHSCISLSSPEQC---SDDCAEGCNCPEGKFYEDTLNFCVPIFHCR 742
            C  G   H C   C  SC  LS    C   S  C   C CP G+  +D L  CVP  HCR
Sbjct: 3529 CGGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGL--CVPPAHCR 3586

Query: 743  CHYR--------------GSVY------QPGELIPTPSGLCQCSNGTVKCDELATPSAVH 782
            C Y+              GS +      +PGE++  P   C C  G ++C E+       
Sbjct: 3587 CQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPG 3646

Query: 783  ICPEGKEYFDC----------------RFPDP-----------------ELPAG------ 803
            +      + DC                R P P                   PAG      
Sbjct: 3647 VWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYREC 3706

Query: 804  --GVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIY 856
              G  C  +CA++     C  S  C  GC C  G  +  +       CP V T +
Sbjct: 3707 QPGEGCPFSCAHVTQQVGCF-SEGCEEGCHCPEGTFQHRL--ACVQECPCVLTAW 3758



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 66/312 (21%), Positives = 106/312 (33%), Gaps = 45/312 (14%)

Query: 851  AVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKC-----FDNDIVCS 905
            A C  +   HY +FDG  Y ++  C   L  +AD +    +    +C          +  
Sbjct: 193  ATCASWSGFHYRTFDGRHYHFLGRCTYLLAGAADSTWAVHLTPGDRCPQPGHCQRVTMGP 252

Query: 906  KSVLISVGDTEIYLNDTPYKQK--QSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDR 963
            + VLI  G+  +     P  Q     G  L+    + +   G  +VV           DR
Sbjct: 253  EEVLIQAGNVSVKGQLVPEGQSWLLHGLSLQWLGDWLVLSGGLGVVVRL---------DR 303

Query: 964  KTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESP--- 1020
              +I I V  +   +  GLCG ++    +D           A  FG+SW L   ES    
Sbjct: 304  TGSISISVDHELWGQTQGLCGLYNGWPEDDFMEPGGGLAMLAATFGNSWRLPGSESGCLD 363

Query: 1021 --------------DETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCH 1066
                          D  ++P          A+  C  L    F  C   +    + + C 
Sbjct: 364  AVEVAQGCDPLGLIDADVEPGHLRAE----AQDVCHQLLEGPFGQCHAQVSPAEYHEACL 419

Query: 1067 EDTCNCNLGGD-----CECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDC---EYYNEGL 1118
               C   + G       + +C + A+Y   C +  I I WR    C   C   + Y++ +
Sbjct: 420  FAYCAGAMAGSGQEGRQQAVCATFASYVQACARRHIHIRWRKPGFCERLCPGGQLYSDCV 479

Query: 1119 GEGPYMLASYGQ 1130
               P    + GQ
Sbjct: 480  SLCPPSCEAVGQ 491



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 34/100 (34%), Positives = 42/100 (42%), Gaps = 9/100 (9%)

Query: 329  DKCDDSFVHRDCISCCPPTCT--FEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPC 386
            D C   F    C S C   C      Q       C  GCYCP GL+   G CI  E C C
Sbjct: 4421 DSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNC 4480

Query: 387  GFH------GLAYSVGSKIEQECTECVCVGGVWNCTEQDC 420
             +H      G+  + G +++  C EC C  G  +CT Q C
Sbjct: 4481 -WHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGC 4519



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 11/105 (10%)

Query: 325  PACTDKCDDSFVHRDCISCCPPTCTF---EKQCLGSNLHCLDGCYCPDGLVMDNGTCISL 381
            P C  +  D+    DC + CP +C       QCL     C  GC CP G ++ +G C+ +
Sbjct: 4665 PEC--EAQDTVFTLDCANQCPHSCADLWDRVQCLQGP--CRPGCRCPPGQLVQDGRCVPI 4720

Query: 382  ENCPCGFHGLAYS----VGSKIEQECTECVCVGGVWNCTEQDCPV 422
             +C CG      S        ++ +C  C CV     C  Q+CPV
Sbjct: 4721 SSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPV 4765



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 12/133 (9%)

Query: 656  CNALAHYAYLC-GQHGVPIDFRTQISFCAVVCQKGMLY------HHCSSFCLHSCISLSS 708
            C++LA     C G H    D  TQ   C   C + ML+      H     C   C++   
Sbjct: 2857 CSSLAPGDTTCPGPHSQTRDCNTQP--CTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGP 2914

Query: 709  PEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPS-GLCQCSN 767
              +C+  CA GC CP G F  +    C+P   C C   G +Y  G +    S   C C +
Sbjct: 2915 GIECTGFCAPGCTCPPGLFLHNA--SCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVS 2972

Query: 768  GTVKCDELATPSA 780
            G + C     P A
Sbjct: 2973 GKMACTSERCPVA 2985



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 25/69 (36%), Positives = 34/69 (49%), Gaps = 2/69 (2%)

Query: 702  SCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSG 761
            SC  LS+P   +  C  GC+CP G    +  N CVP   C C + G +Y PG  +  P  
Sbjct: 3105 SCAELSAPRGTNQTCHPGCHCPSGMLLLN--NVCVPTQDCPCAHEGHLYPPGSTVVRPCE 3162

Query: 762  LCQCSNGTV 770
             C C +G +
Sbjct: 3163 NCSCVSGLI 3171



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 5/99 (5%)

Query: 327  CTDKCDDSFVHRDCISCCPPTCTFEKQ---CLGSNLHCLDGCYCPDGLVMDNGTCISLEN 383
            C   C        C + CP  C+  ++   C    + C  GC CP G +  +G C+ + +
Sbjct: 4058 CEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQV-CQKGCRCPKGSLEQDGGCVPIGH 4116

Query: 384  CPC-GFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCP 421
            C C    G +++ GS+ +  C  C C  G  +CT Q CP
Sbjct: 4117 CDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCP 4155



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 47/184 (25%), Positives = 59/184 (32%), Gaps = 46/184 (25%)

Query: 695  CSSFCLHSCISLSSPEQC-SDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGS----V 749
            C++ C HSC  L    QC    C  GC CP G+  +D    CVPI  CRC    +     
Sbjct: 4678 CANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQD--GRCVPISSCRCGLPSANASWE 4735

Query: 750  YQPGELIPTPSGLCQCSNGTVKCDELATP--------------------SAVHICPEGKE 789
              P + +      C C N ++ C     P                         C  G  
Sbjct: 4736 LAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPG 4795

Query: 790  YFDCRFPD------------PELPAGGV------NCETTCANLAMNFTCTPSSPCISGCV 831
               C+  D            PE P G V      +C   C +L     C    PC  GC 
Sbjct: 4796 VAPCQAQDTEQRQECNLQPCPECPPGQVLSACATSCPCLCWHLQPGAICV-QEPCQPGCG 4854

Query: 832  CAPG 835
            C  G
Sbjct: 4855 CPGG 4858



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 50/180 (27%), Positives = 62/180 (34%), Gaps = 38/180 (21%)

Query: 683  AVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCR 742
            A +CQKG++       C  SC+   +   CS  C EGC CP G    DT   C+P+  C 
Sbjct: 2624 ADLCQKGLVPP-----CPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTR--CLPLSECP 2676

Query: 743  CHYRGSVYQPG-ELIPTPSGLCQCSNGTVKCDELATP------------SAVHICPEGKE 789
            C     +  PG   +      C C  G + C     P                 C  G  
Sbjct: 2677 CLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVR 2736

Query: 790  YFDCRFPDPELPA---GGVNCE----------TTCANLAMNFT-CTPSSPCISGCVCAPG 835
                RF  P  P    GG  CE          T C      +T  T  S C   C+ APG
Sbjct: 2737 ---ARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQSCL-APG 2792



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 36/130 (27%), Positives = 52/130 (40%), Gaps = 18/130 (13%)

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSN 358
            YC         C     P+ +       CT    +   +  C   CP +C     C+   
Sbjct: 3290 YCEGPRAQGEVCQALPCPVTN-------CT--AIEGAEYSPCGPPCPRSCDDLVHCVW-- 3338

Query: 359  LHCLDGCYCPDGLVMD-NGT-CISLENCPCG--FHGLAYSVGSKIEQE--CTECVCVGGV 412
              C  GCYCP G V+  NG  C+   +C C     G  +  G+++ +   C  C C+ G 
Sbjct: 3339 -RCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGR 3397

Query: 413  WNCTEQDCPV 422
             NCT+  CPV
Sbjct: 3398 LNCTDLPCPV 3407



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 32/102 (31%), Positives = 38/102 (37%), Gaps = 7/102 (6%)

Query: 688  KGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRC--HY 745
            +G  Y  C   C  SC  L     C   C  GC CP G+        CV   HC C    
Sbjct: 3315 EGAEYSPCGPPCPRSCDDLV---HCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLL 3371

Query: 746  RGSVYQPGELIPTPSGL--CQCSNGTVKCDELATPSAVHICP 785
             G  + PG  +  P G   C C  G + C +L  P     CP
Sbjct: 3372 TGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCP 3413



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 36/139 (25%), Positives = 55/139 (39%), Gaps = 18/139 (12%)

Query: 300  CRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCI----SCCPPTCTFEKQCL 355
            C +     R C+     +   R   P   D C ++    + +    + CP TC      +
Sbjct: 1776 CHSPQNGGRTCAALPGGLHSTRQTKPCPQDGCPNATCSGELMFQPCAPCPLTC----DDI 1831

Query: 356  GSNLHC-------LDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECV 407
               + C         GC+CP+G V+ + G C+    CPC   G  Y  G +I+ +C  C+
Sbjct: 1832 SGQVTCPPDWPCGSPGCWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCI 1891

Query: 408  CVGG-VWNC-TEQDCPVQC 424
            C  G    C    DC V C
Sbjct: 1892 CQDGRPRRCRLNPDCAVDC 1910



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 47/172 (27%), Positives = 58/172 (33%), Gaps = 42/172 (24%)

Query: 686  CQKGMLYHHCSSFCLHSCISLSSPEQC-SDDCAEGCNCPEGKFYEDTLNFCVPIFHCRC- 743
            C  G +   C++ C   C  L     C  + C  GC CP G+   +    CVP   C C 
Sbjct: 4818 CPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHN--GTCVPPTACPCT 4875

Query: 744  ------------HYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYF 791
                          +     PG ++      C C  G   C  +                
Sbjct: 4876 QHSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLV---------------- 4919

Query: 792  DCRFPDPEL-----PAGGVNCETTCANLAMNFTCTPS---SPCISGCVCAPG 835
            DC+ P  E      P     CE TC  L MN T T S   S   SGCVC PG
Sbjct: 4920 DCQVPPGETWQQVAPGELGLCEQTC--LEMNATKTQSNCSSARASGCVCQPG 4969



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 9/94 (9%)

Query: 686  CQKGMLYHHCSSFCLHSCISLSSPEQCSD--DCAEGCNCPEGKFYEDTLNFCVPIFHCRC 743
            C     +H C S C   C +  S + C D   C  GC CP+G    +    C+P   C C
Sbjct: 4423 CTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLL--EQAGGCIPPEECNC 4480

Query: 744  HY-----RGSVYQPGELIPTPSGLCQCSNGTVKC 772
             +      G    PG+ +      C+C  G + C
Sbjct: 4481 WHTSAAGAGMTLAPGDRLQLGCKECECRRGELHC 4514



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 133/558 (23%), Positives = 188/558 (33%), Gaps = 121/558 (21%)

Query: 1712 CVRPCEARTCLNQWFYGHTSCLN--LREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQ 1769
            C   C   +C + W      CL    R  C C  G ++      +C+P   C C      
Sbjct: 4678 CANQCP-HSCADLW--DRVQCLQGPCRPGCRCPPGQLVQ---DGRCVPISSCRCGLP--- 4728

Query: 1770 PRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSK 1829
              +A   W     +     C +N + +     C  +  PV        +G    W+ CS 
Sbjct: 4729 --SANASWELAPAQAVQLDC-QNCTCVNESLVCPHQECPV--------LGPWSAWSSCSA 4777

Query: 1830 EVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCP-QYKCECDPLKCPSISTPECREDQFM 1888
              CG  T        TC        G +P      + + EC+   CP     EC   Q +
Sbjct: 4778 P-CGGGTMERHR---TCEGGP----GVAPCQAQDTEQRQECNLQPCP-----ECPPGQVL 4824

Query: 1889 IQVRQEEPC-CF----SPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNL 1943
                   PC C+       CV E C +P   C  G+ L    N T  C P   C C  + 
Sbjct: 4825 SACATSCPCLCWHLQPGAICVQEPC-QPGCGCPGGQLLH---NGT--CVPPTACPCTQHS 4878

Query: 1944 CPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEVGEFTAIDHNFQSDCGCI 2003
             P  L        L  E  + +  P      NC   V   C  G F+           C 
Sbjct: 4879 LPWGL-------TLTLEEQAQELPPGTVLTRNCTRCV---CHGGAFS-----------CS 4917

Query: 2004 QYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSK 2063
               C+      +Q+V+   PG+     L E  C  +   +             T  NCS 
Sbjct: 4918 LVDCQVPPGETWQQVA---PGELG---LCEQTCLEMNATK-------------TQSNCSS 4958

Query: 2064 KCDVHQVYTPSP--SDYGCCGTCKNVSCKFHMENGTSVVYAVGSTWHYNCTTYECVKTDE 2121
                  V  P    S  G C    +  C +H+       +  GS W   C +  C+    
Sbjct: 4959 ARASGCVCQPGHFRSQAGPCVPEDHCEC-WHLGRP----HLPGSEWQEACESCLCLS--- 5010

Query: 2122 GAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKRE-----ERICQKVIIKSVIRK 2176
            G  +   T  C P     C   E +V L    CC  C+RE        CQ +       K
Sbjct: 5011 GRPVC--TQHCSPLT---CAQGEEMV-LEPGSCCPSCRREAPEEQSPSCQLLTELRNFTK 5064

Query: 2177 QDCMSQSPINVASCDGKCPSATIYNINIESHLRF-CKCCR-----ENGVRNLSVPLYCSG 2230
              C     + V+ C G CPS+T + +  E +L+  C CC      E+ VR L+  L C G
Sbjct: 5065 GTCYLDQ-VEVSYCSGYCPSST-HVMPEEPYLQSQCDCCSYRLDPESPVRILN--LRCLG 5120

Query: 2231 NGTEIMYTLQEPIDCTCQ 2248
              TE +     P+  +CQ
Sbjct: 5121 GHTEPVVL---PVIHSCQ 5135



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 27/94 (28%), Positives = 40/94 (42%), Gaps = 7/94 (7%)

Query: 699  CLHSCISLSSPE---QCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGEL 755
            C  +C+ +++ +    CS   A GC C  G F       CVP  HC C + G  + PG  
Sbjct: 4940 CEQTCLEMNATKTQSNCSSARASGCVCQPGHFRSQA-GPCVPEDHCECWHLGRPHLPGSE 4998

Query: 756  IPTPSGLCQCSNGTVKCDELATPSAVHICPEGKE 789
                   C C +G   C +  +P     C +G+E
Sbjct: 4999 WQEACESCLCLSGRPVCTQHCSPLT---CAQGEE 5029



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 36/158 (22%), Positives = 55/158 (34%), Gaps = 37/158 (23%)

Query: 300  CRAATEYARACSHAGYP------------IQDWRDDFPACTDKCDDSFVHRDCISCCPPT 347
            C   +  +RACS    P             +  +++   CTD      +H  C   CP +
Sbjct: 3487 CLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLH-PCGQPCPRS 3545

Query: 348  C---TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSV--------- 395
            C   +    C   ++ C   C CP G +  +G C+   +C C +   A  +         
Sbjct: 3546 CQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAG 3605

Query: 396  -----------GSKIEQECTECVCVGGVWNCTE-QDCP 421
                       G  +   C  C CV G+  C E  DCP
Sbjct: 3606 SRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCP 3643



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 6/90 (6%)

Query: 341  ISCCPPTCTFEKQCLGSNLHC----LDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSV 395
            +  C  TC  E     +  +C      GC C  G      G C+  ++C C   G  +  
Sbjct: 4937 LGLCEQTC-LEMNATKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDHCECWHLGRPHLP 4995

Query: 396  GSKIEQECTECVCVGGVWNCTEQDCPVQCS 425
            GS+ ++ C  C+C+ G   CT+   P+ C+
Sbjct: 4996 GSEWQEACESCLCLSGRPVCTQHCSPLTCA 5025



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 45/173 (26%), Positives = 60/173 (34%), Gaps = 44/173 (25%)

Query: 686  CQKGMLYHHCS--SFCLHSCISLSSPEQC-SDDCAEGCNCPEGKFYEDTLNFCVPIFHCR 742
            C  G LY  C     C  SC  ++    C S+ C EGC+CPEG F       CV    C 
Sbjct: 3697 CPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLA--CVQ--ECP 3752

Query: 743  CHYR--------------------GSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVH 782
            C                       G     G+ + T  G C C++G + C       ++ 
Sbjct: 3753 CVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSC-------SLD 3805

Query: 783  ICPEGKEYFDCRFPDPELPAGGVNCETTCANL---AMNFTCTPSSPCISGCVC 832
             C E    F      P  P G   C  +C  L     +  C  + P +SG  C
Sbjct: 3806 DCFEADGGF-----GPWSPWG--PCSRSCGGLGTRTRSRQCVLTMPTLSGQGC 3851



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 64/301 (21%), Positives = 95/301 (31%), Gaps = 80/301 (26%)

Query: 1703 CPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN--LREDCVCKVGTILHRPHSAQCIPEKE 1760
            CP G+    C   C    CL         C+    +  C C  G +LH   +  C+P   
Sbjct: 4818 CPPGQVLSACATSCP---CLCWHLQPGAICVQEPCQPGCGCPGGQLLH---NGTCVPPTA 4871

Query: 1761 CACT------------DSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTP 1808
            C CT            + + Q    G +       C  +    + S++    DC   P  
Sbjct: 4872 CPCTQHSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLV----DCQVPPGE 4927

Query: 1809 VCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGH---SPLSCCPQY 1865
              ++ A   +G+ ++ TC         +         C        GH       C P+ 
Sbjct: 4928 TWQQVAPGELGLCEQ-TCLEMNATKTQSNCSSARASGCVCQP----GHFRSQAGPCVPED 4982

Query: 1866 KCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDL 1925
             CEC  L  P +   E +E                    CESC     LC  G  +    
Sbjct: 4983 HCECWHLGRPHLPGSEWQE-------------------ACESC-----LCLSGRPV---- 5014

Query: 1926 NSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCE 1985
                  C Q+   C P       L CA+   +V E   G CCP+  C         P+C+
Sbjct: 5015 ------CTQH---CSP-------LTCAQGEEMVLE--PGSCCPS--CRREAPEEQSPSCQ 5054

Query: 1986 V 1986
            +
Sbjct: 5055 L 5055



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 5/86 (5%)

Query: 686  CQKGMLYHHCSSFCLHSCISLSSPEQCSDDC---AEGCNCPEGKFYEDTLNFCVPIFHCR 742
            C   +++  C+  C  +C  +S    C  D    + GC CPEG+       +CV    C 
Sbjct: 1812 CSGELMFQPCAP-CPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSE-GWCVWPRQCP 1869

Query: 743  CHYRGSVYQPGELIPTPSGLCQCSNG 768
            C   G+ Y PG+ I     LC C +G
Sbjct: 1870 CLVDGARYWPGQRIKADCQLCICQDG 1895



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 28/113 (24%), Positives = 44/113 (38%), Gaps = 25/113 (22%)

Query: 331  CDDSFVHRDCI--SCCPPTCTFEKQCLGS-NLHCLDGCYCPDGLVMDNGTCISLENCPC- 386
            C    ++R+C     CP +C    Q +G  +  C +GC+CP+G       C+  + CPC 
Sbjct: 3697 CPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACV--QECPCV 3754

Query: 387  -------------GFHGLAYSVGSKIEQ------ECTECVCVGGVWNCTEQDC 420
                         G  G     G +++        C  C C  G  +C+  DC
Sbjct: 3755 LTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDC 3807



 Score = 40.8 bits (94), Expect = 0.015
 Identities = 76/323 (23%), Positives = 98/323 (30%), Gaps = 86/323 (26%)

Query: 1700 SLSCP-------EGKEYQPCVRPCEARTCLNQWFYGHTSCL-NLREDCVCKVGTILHRPH 1751
            +L CP       EG EY PC  PC  R+C +        C+   +  C C  G +L   +
Sbjct: 3303 ALPCPVTNCTAIEGAEYSPCGPPC-PRSCDDL-----VHCVWRCQPGCYCPPGQVL-SSN 3355

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPV-- 1809
             A C+    C+C D     R          D C    CLE         +C + P PV  
Sbjct: 3356 GAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEG------RLNCTDLPCPVPG 3409

Query: 1810 --CEREAEVVMGIIDKWTCCSK----------EVCGCDTTLCETSIPTCTNSQKLIVGHS 1857
              C            +WT CS+            C C T   +     CT          
Sbjct: 3410 GWCP---------WSEWTMCSQPCRGQTRSRSRACACPTP--QHGGAPCTGEAGEAGAQH 3458

Query: 1858 PLSCCPQY-KCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVP--- 1913
                CP Y  C  D    P      C  D  + Q  +   C   P        +P P   
Sbjct: 3459 QREACPSYATCPVDGAWGPWGPWSPC--DMCLGQSHRSRACSRPP---TPEGGRPCPGNH 3513

Query: 1914 ----LCHDGEFLTVDL---NSTHFC---CPQYY------CVCEPN------LCPMPLLNC 1951
                 C +      D     S H C   CP+         VC+P        C  PL   
Sbjct: 3514 TQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQL 3573

Query: 1952 AEDMNLVKENVSGQCCPTWHCEC 1974
            ++D         G C P  HC C
Sbjct: 3574 SQD---------GLCVPPAHCRC 3587



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 52/237 (21%), Positives = 72/237 (30%), Gaps = 57/237 (24%)

Query: 1696 PDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHR------ 1749
            P  C   CP G E   C   C  R            C +L+E  VC+   +  +      
Sbjct: 4055 PMPCEAGCPAGMEVVTCANRCPRR------------CSDLQEGIVCQDDQVCQKGCRCPK 4102

Query: 1750 ---PHSAQCIPEKECACTDSEDQPRTAGEIWNGGI---DECTLYKCLENGSIIPIEPDCD 1803
                    C+P   C CTD++      G  W  G    D C    C + G +      C 
Sbjct: 4103 GSLEQDGGCVPIGHCDCTDAQ------GHSWAPGSQHQDACNNCSC-QAGQL-----SCT 4150

Query: 1804 EEPTPVCEREAEVVMGIIDKWTCCSKEVCG-------CDTTLCETSIPTCTNSQKLIVGH 1856
             +P   C             W+ CS   CG         ++   +  P C   Q      
Sbjct: 4151 AQP---CPPPTHCAWSHWSAWSPCSHS-CGPRGQQSRFRSSTSGSWAPECREEQ------ 4200

Query: 1857 SPLSCCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVP 1913
            S    CPQ  C   P  C   +      D + +Q   +   C     +CE     VP
Sbjct: 4201 SQSQPCPQPSC---PPLCLQGTRSRTLGDSW-LQGECQRCSCTPEGVICEDTECAVP 4253



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 18/52 (34%), Positives = 22/52 (42%), Gaps = 5/52 (9%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDC 1332
            Y PC  PC ++C D      +  P   GC  YCP   +L      CV P  C
Sbjct: 3319 YSPCGPPCPRSCDDLVHCVWRCQP---GC--YCPPGQVLSSNGAICVQPGHC 3365



 Score = 33.5 bits (75), Expect = 2.4
 Identities = 35/148 (23%), Positives = 53/148 (35%), Gaps = 38/148 (25%)

Query: 1699 CSLSCPEGKEYQPCVR------PCEARTCLNQWFYGHTSCLNL-REDCVCKVGTILHRPH 1751
            C+  CPE   ++   +      PC  R CL Q       C       C C  G  LH   
Sbjct: 2882 CTAQCPENMLFRSAEQCHQEGGPCP-RLCLTQG--PGIECTGFCAPGCTCPPGLFLH--- 2935

Query: 1752 SAQCIPEKECACTDSEDQPRTAGEIWNGG----IDECTLYKCLENGSIIPIEPDCDEEPT 1807
            +A C+P  +C C       +  G+++  G    +D C    C+        +  C  E  
Sbjct: 2936 NASCLPRSQCPC-------QLHGQLYASGAMARLDSCNNCTCVSG------KMACTSERC 2982

Query: 1808 PVCEREAEVVMGIIDKWTCCSKEVCGCD 1835
            PV    +   +     W+ CS   C C+
Sbjct: 2983 PVACGWSPWTL-----WSLCS---CSCN 3002



 Score = 32.7 bits (73), Expect = 4.1
 Identities = 33/129 (25%), Positives = 47/129 (36%), Gaps = 31/129 (24%)

Query: 1673 ECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC 1732
            +C+    YV+     D+C +   P      CP       C+ P   R+C      GH  C
Sbjct: 2614 DCELGRVYVSA----DLCQKGLVPP-----CPPS-----CLDPKANRSCS-----GH--C 2652

Query: 1733 LNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYK---- 1788
            +   E C C  G +LH     +C+P  EC C   E+          G   +C   K    
Sbjct: 2653 V---EGCRCPPGLLLH---DTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELL 2706

Query: 1789 CLENGSIIP 1797
            C   G  +P
Sbjct: 2707 CQPGGCPLP 2715



 Score = 32.7 bits (73), Expect = 4.1
 Identities = 17/55 (30%), Positives = 22/55 (40%), Gaps = 7/55 (12%)

Query: 783  ICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVC 837
            +CP  K++ DC         G  +C    A    N TC P   C SG +    VC
Sbjct: 3089 MCPRDKQWLDCA-------QGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVC 3136



 Score = 31.6 bits (70), Expect = 9.2
 Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 2/56 (3%)

Query: 807  CETTCANLAMNFTCTPSSPCIS-GCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHY 861
            C  TC +++   TC P  PC S GC C  G    G      +P    C + G R++
Sbjct: 1824 CPLTCDDISGQVTCPPDWPCGSPGCWCPEGQV-LGSEGWCVWPRQCPCLVDGARYW 1878


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score =  447 bits (1150), Expect = e-125
 Identities = 313/1142 (27%), Positives = 505/1142 (44%), Gaps = 117/1142 (10%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            G C TWG  HF TFD   Y F G C+YIFA  C D  P ++V +   P   GS+      
Sbjct: 43   GQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPD--GSISRIIVE 100

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILV---KTTFGFSLAWDG 178
            +        E  I    +K  G+ ++LP T   + I      + +   +      + W  
Sbjct: 101  LGASVVTVSEAII---SVKDIGV-ISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGP 156

Query: 179  ISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCV 238
             S + + +   + G+ CGLCGN++   +++F+  +  + E     A    +Q  DD   +
Sbjct: 157  DSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAA----LQKLDDPGEI 212

Query: 239  LTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDD--- 295
             T  D P+  +    A  A    C  LL      C    +P+  + SC  D+        
Sbjct: 213  CTFQDIPS--THVRQAQHARI--CTQLLTLVAPECSVSKEPF--VLSCQADVAAAPQPGP 266

Query: 296  DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCL 355
              + C   +EY+R CS  G P++ WR        +C  + V+++C S C  TC+  +   
Sbjct: 267  QNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSNPQHSC 326

Query: 356  GSNLHCLDGCYCPDGLVMD----NGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGG 411
             S+  C  GC+CP+G V++    N TC+ +  CPC  HG  Y+ G      C  C C  G
Sbjct: 327  SSS--CTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLG 384

Query: 412  VWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQN 471
             W CTE+ CP  CS+ G S  TTFD R Y F G C YIL++            + P +  
Sbjct: 385  RWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSP----------QLPEDGA 434

Query: 472  LGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGI----------VEIQTLSS 521
            L  V  +S     E      V L R  +I+ S ++    NG           + +   +S
Sbjct: 435  LMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTS 494

Query: 522  LFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGT 580
              + + T+FGL+++  +    + Y+ +   ++ +T GLCG FNG+  DDF +  G+ EGT
Sbjct: 495  THLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGT 554

Query: 581  PQLHANAWRVSSTCFAPVHVPVVDPCNINQQN-IGYAAHCDVIHQE--LFAPCHIYISPG 637
              L  ++WR  + C A +     DPC+++Q N +    HC ++ +   +F  CH  ++P 
Sbjct: 555  ASLFVDSWRAGN-CPAALERET-DPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPA 612

Query: 638  LYYQLCRHDACKCGSSC--LCNALAHYAYLCGQHGVPI-DFRTQISFCAVVCQKGMLYHH 694
             +Y+ C + AC    +   +C AL  Y + C   GV +  +R+ +  C + C     + +
Sbjct: 613  PFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSY 672

Query: 695  CSSFCLHSCISLSS-PEQCSDDCA--EGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQ 751
             S  C  +C+SLS    +C       +GCNCP+G  Y +    CV    C C   G  + 
Sbjct: 673  NSQACERTCLSLSDRATECHHSAVPVDGCNCPDGT-YLNQKGECVRKAQCPCILEGYKFI 731

Query: 752  PGELIPTPSGL-CQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETT 810
              E     +G+ C C NG + C +      +  C   K +  C          G  C  T
Sbjct: 732  LAEQSTVINGITCHCINGRLSCPQ-RPQMFLASCQAPKTFKSCSQSSEN--KFGAACAPT 788

Query: 811  CANLAMNFTCTPSSPCISGCVCAPGV---------------------------------- 836
            C  LA    C P+  C  GCVCA G+                                  
Sbjct: 789  CQMLATGVACVPTK-CEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDCR 847

Query: 837  ---CRRGMFNCTYYP-CPAVCTIYGDRHYYSFDGLEYDYISDCQVFL---IKSADDSD-- 887
               C RG + C     CP+ CT+YG+ H  +FDG  + +  +C+  L   +   +DS   
Sbjct: 848  TCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPT 907

Query: 888  ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYY 947
              ++ +N  C ++ + CS+++ I +G   + L D  Y        ++   T         
Sbjct: 908  FKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGA--LSLV 965

Query: 948  IVVYFPEK-DITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNAR 1006
            + +  P + ++T++W+R  TI I++    ++ L GLCGNF+    +D  T +     +  
Sbjct: 966  VDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSEL 1025

Query: 1007 VFGDSWALGQ-CESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNC 1065
               +SW     C        PC  +  +  +A+++CS++ S  FA+C + +    + + C
Sbjct: 1026 ELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEAC 1085

Query: 1066 HEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN----EGLGEG 1121
              D C C+ GGDCECLC ++AAYA  C  +G+ + WR+   C + C +YN    +G GE 
Sbjct: 1086 VRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEY 1145

Query: 1122 PY 1123
             Y
Sbjct: 1146 QY 1147



 Score =  110 bits (276), Expect = 1e-23
 Identities = 108/435 (24%), Positives = 167/435 (38%), Gaps = 37/435 (8%)

Query: 12  TFFFFSPSGSCPYECLNGAFCSKTGTCDCQIFQAL------------GTRCQIIPNMGNG 59
           TF  F P G+   +  N   C     C C +  A+              RC +   +   
Sbjct: 331 TFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVCTE 390

Query: 60  R--DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYS 117
           R   G C   G     TFD   Y F G C+YI  +     E    + V++      S  S
Sbjct: 391 RPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETS 450

Query: 118 CYRSISLFFSNQEEIRIYGHE-IKKNGISLTLPQTIGQIFI-EKLADYILVKTTFGFSLA 175
               +  + S Q++I I   E +  NG +  LP     I +  + + ++ + T+FG  L 
Sbjct: 451 LVAVV--YLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELV 508

Query: 176 WD--GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
                I   Y+ +    +G++ GLCGN+N   +DDF           ++F +SW      
Sbjct: 509 VQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRA---- 564

Query: 234 DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQ--FPFLSCHEYIDPYLYIASCVNDLC 291
              C        +PCS            C +LL+    F  CH  ++P  +   CV   C
Sbjct: 565 -GNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQAC 623

Query: 292 KTDDDETY-CRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF 350
             ++   + C A  +Y  ACS  G  +  WR     CT  C  +         C  TC  
Sbjct: 624 NYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLS 683

Query: 351 ----EKQCLGSNLHCLDGCYCPDGLVMD-NGTCISLENCPCGFHGLAYSVG--SKIEQEC 403
                 +C  S +  +DGC CPDG  ++  G C+    CPC   G  + +   S +    
Sbjct: 684 LSDRATECHHSAVP-VDGCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGI 742

Query: 404 TECVCVGGVWNCTEQ 418
           T C C+ G  +C ++
Sbjct: 743 T-CHCINGRLSCPQR 756



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 83/353 (23%), Positives = 148/353 (41%), Gaps = 38/353 (10%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIP----GEIIVAHIEKCSMNQA 1487
            C E  CP  CS+     + TFD      +   +YIL++ P       ++A  +K  ++ +
Sbjct: 388  CTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHS 447

Query: 1488 PSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYV-IT 1546
             +  ++ +   + +      KI++++    V  +     LP+ ++ +++    S ++ + 
Sbjct: 448  ETSLVAVVYLSRQD------KIVISQ-DEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMA 500

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
            T  GL +    L  I   +          T GLCG  N D  DD     G          
Sbjct: 501  TSFGLELV-VQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIA---EGTAS 556

Query: 1607 LFIESWE-------IEKSFE-VTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDF 1658
            LF++SW        +E+  +  +M +  + C E  CS    L    +F  CH  V+P  F
Sbjct: 557  LFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSML--LRTGTVFERCHATVNPAPF 614

Query: 1659 ---CEKMWINYTYFWNYECDALSAYVALCNKFDICI-QWRTP-DYCSLSCPEGKEYQPCV 1713
               C     NY   + + C AL  YV  C+   + +  WR+  D C++ C     +    
Sbjct: 615  YKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNS 674

Query: 1714 RPCEARTCL---NQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
            + CE RTCL   ++    H S + + + C C  GT L++    +C+ + +C C
Sbjct: 675  QACE-RTCLSLSDRATECHHSAVPV-DGCNCPDGTYLNQ--KGECVRKAQCPC 723



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 95/433 (21%), Positives = 160/433 (36%), Gaps = 111/433 (25%)

Query: 1374 TGLECEPQKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDI--- 1430
            TG+ C P K +P   C++ +  N + Q       C    E P C F G      +++   
Sbjct: 794  TGVACVPTKCEPGCVCAEGLYENADGQ-------CVPPEECP-CEFSGVSYPGGAELHTD 845

Query: 1431 ------------CCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAH 1478
                        C     CP  C++  E  +ITFDG          YIL           
Sbjct: 846  CRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILAT--------- 896

Query: 1479 IEKCSMNQAPSGRISGLCFKKL--NVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSI 1536
             + C +N +         FK L  NV      +  +R A K+ +  + V L   +  ++ 
Sbjct: 897  -DVCGVNDSQP------TFKILTENVICGNSGVTCSR-AIKIFLGGLSVVLADRNYTVTG 948

Query: 1537 EDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLS---------------SYTEGLCG 1581
            E+      +T  A        L+ ++DI    R+NL+               +  + LCG
Sbjct: 949  EEPHVQLGVTPGA--------LSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCG 1000

Query: 1582 IC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEI-----EKSFEV---TMRRPVRNCT 1630
            +C   N +  DD   ++  + ++  ++   + SW+      + SF     ++    R+  
Sbjct: 1001 LCGNFNGNMKDDFETRSRYVASSELEL---VNSWKESPLCGDVSFVTDPCSLNAFRRSWA 1057

Query: 1631 EHDCSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVALCN 1685
            E  CS    ++N + F  CH KV    +   C +         + EC  DA++AY   C 
Sbjct: 1058 ERKCS----VINSQTFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVAAYAQACL 1113

Query: 1686 KFDICIQWRTPDYCSLSC-------PEGK-------------EYQPCVRPCEARTCLNQW 1725
               +C+ WRTP +C + C        +G               YQPC+ P + ++     
Sbjct: 1114 DKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSN 1173

Query: 1726 FYGHTSCLNLRED 1738
              G   C N  +D
Sbjct: 1174 IEG---CYNCSQD 1183



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 50/269 (18%), Positives = 107/269 (39%), Gaps = 16/269 (5%)

Query: 848  PCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKS 907
            P    C+ +G  H+ +FD   YD+   C      +  D+  +   Q ++  D  I     
Sbjct: 40   PDKGQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSI---SR 96

Query: 908  VLISVGDTEIYLNDTPYKQKQSGF----FLENKSTYQLWKAGYYIVVYFPEKDITILWDR 963
            +++ +G + + +++     K  G     +  N      +     +V    E ++ ++W  
Sbjct: 97   IIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGP 156

Query: 964  KTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDE- 1022
             + + + V  ++  ++ GLCGNFD   +N+  +     +   +      AL + + P E 
Sbjct: 157  DSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFA----ALQKLDDPGEI 212

Query: 1023 -TIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECL 1081
             T +   +   +     + C+ L + +   C   +    F  +C  D       G     
Sbjct: 213  CTFQDIPSTHVRQAQHARICTQLLTLVAPECS--VSKEPFVLSCQADVAAAPQPGPQNSS 270

Query: 1082 CTSIAAYAYKCCQEGISI-HWRSSTVCSL 1109
            C +++ Y+ +C   G  +  WRS  +CS+
Sbjct: 271  CATLSEYSRQCSMVGQPVRRWRSPGLCSV 299



 Score = 38.5 bits (88), Expect = 0.075
 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 15/98 (15%)

Query: 2153 GCCKICKREERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCK 2212
            G C + +++E I  K           CM+   + V  C+G C SA  +NI  +     C 
Sbjct: 2347 GVCSVREQQEEITFK----------GCMAN--VTVTRCEGACISAASFNIITQQVDARCS 2394

Query: 2213 CCRENGVRNLSVPLYC---SGNGTEIMYTLQEPIDCTC 2247
            CCR        + L C   S  G  ++ TLQ    C C
Sbjct: 2395 CCRPLHSYEQQLELPCPDPSTPGRRLVLTLQVFSHCVC 2432



 Score = 33.5 bits (75), Expect = 2.4
 Identities = 31/102 (30%), Positives = 42/102 (41%), Gaps = 23/102 (22%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVI 1336
            C W Y+PC  P     S P+++       +EGC   C ++   D     CV    C+P  
Sbjct: 1153 CTWHYQPCLCP-----SQPQSVPGS---NIEGCY-NCSQDEYFDHEEGVCV---PCMP-- 1198

Query: 1337 PTEPTLMPPAKPTVPM-----FTVWEMITPSDITVFDMLTPT 1373
            PT P   PP  P +P        VW M   S  T   +L+ T
Sbjct: 1199 PTTP--QPPTTPQLPTTGSRPTQVWPMTGTS--TTIGLLSST 1236


>gi|239750277 PREDICTED: hypothetical protein XP_002347351 [Homo
            sapiens]
          Length = 2134

 Score =  400 bits (1027), Expect = e-110
 Identities = 255/942 (27%), Positives = 418/942 (44%), Gaps = 91/942 (9%)

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYI---DPYLYIASCVNDLCKTDDDE 297
            P D PN         E     C  ++   F  C +     + Y  I  C+++ C+T D  
Sbjct: 668  PGDCPNAVGKSYEVCEDGIQHCNKIIGTYFEKCGKVAALSNDYKMI--CIDEYCQTRDKT 725

Query: 298  TYCRAATEYARACSHAGY-PIQDWRDDFPAC--TDKCDDSFVHRDCISCCPPTCTFEKQC 354
            + C   +E +R C+  G    + WR D      T +C +  ++++C    P TC+     
Sbjct: 726  STCDTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYKECGPSNPATCSNVAPF 785

Query: 355  LGSNLHCLDGCYCPDGLVMDN----GTCISLENCPCGFHGLAYSVGSKIEQEC-TECVCV 409
              S   C+ GC CP+G ++D+    G C+    CPC   G  Y  G   E  C ++C C 
Sbjct: 786  QDSE--CVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQ 843

Query: 410  GGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCE 469
               W+CTE  CP +C V G S  TTFDG  Y+F G C ++ V     + ++I+++  PC 
Sbjct: 844  DAKWSCTEALCPGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHN---EDWSISVELRPCP 899

Query: 470  QNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSP---NQGFNLNGIVEIQTLSSLFILL 526
                  CL S+TL+L         +      +T+    NQG+  +  ++I   SS ++ +
Sbjct: 900  SGQTGTCLNSVTLLLNSSVPVDKYVFNSDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQV 959

Query: 527  KTTFGLKILFAI-DGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHA 585
            +T F +K+   I    ++Y+ +       T+GLCG++N    DDF+S   ++E T Q  A
Sbjct: 960  ETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFA 1019

Query: 586  NAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQEL--FAPCHIYISPGLYYQLC 643
            N+W + S    P   P    C   ++      HC ++       A CH  ++P  Y++ C
Sbjct: 1020 NSWEMMS---CPKGNP--SSCISIEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEEC 1074

Query: 644  RHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVVCQKGMLYHHCSSFCL 700
            +   C C +S  CLC  L +Y   C +    I  +RT +  C   C  G+++ +    C 
Sbjct: 1075 KKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACN 1132

Query: 701  HSCISLSSPEQC---SDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIP 757
             SC SLS  ++     D   +GC CP+   Y++    CV    C C+    V QPG+LI 
Sbjct: 1133 SSCRSLSERDRSCDVEDVPVDGCTCPDA-MYQNNEGNCVLKSQCDCYINDEVMQPGKLIH 1191

Query: 758  TPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMN 817
                 C C +G + C ++     +  C  G EY DC  P  +          TC+   + 
Sbjct: 1192 IDDNKCVCRDGILLC-QIPIDLTLQNCSGGAEYVDCSDPKAQR-----RTNRTCSTRNIP 1245

Query: 818  FTCTPSSPCISGCVCAPGV-------------------------------------CRRG 840
                 + PC  GC C  G+                                     C +G
Sbjct: 1246 -VFDENLPCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVGCNECTCIKG 1304

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSA---DDSDISVIAQNKKC 897
             ++CT   C  +C IYG+ H  +FDG  Y +   CQ   ++     ++    ++ ++  C
Sbjct: 1305 SWSCTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPC 1364

Query: 898  FDNDIVCSKSVLISVGDTEIYLND---TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPE 954
             ++ + CS+ ++++  D  I L D   T  K  +S     N + Y +   G Y+++ F +
Sbjct: 1365 CEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKF-Q 1423

Query: 955  KDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL 1014
              I ++WD+ T + + + P W  K+ GLCGN +    +D TT  +     A  FG+SW  
Sbjct: 1424 NGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKT 1483

Query: 1015 GQ-CESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCN 1073
             Q C        PC+++     +A ++C IL    F  C N +D +++   C E+ C C+
Sbjct: 1484 SQECSDTVAQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACD 1543

Query: 1074 LGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
            + G     CT++A YA  C   G+ + WR   +C + C+YYN
Sbjct: 1544 MEGKYLGFCTAVAMYAEACSAVGVCVSWRKPNLCPVYCDYYN 1585



 Score =  207 bits (527), Expect = 9e-53
 Identities = 127/439 (28%), Positives = 201/439 (45%), Gaps = 28/439 (6%)

Query: 358  NLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCT 416
            NL C  GC+CP+G+V ++ G C+   +CPC F G  Y  GS     C EC C+ G W+CT
Sbjct: 1250 NLPCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVGCNECTCIKGSWSCT 1309

Query: 417  EQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK---GTGKDKFTITLQKAPCEQNLG 473
            + +C   C + G+ H  TFDG+ YSF G+CQY  ++   G     F I  +  PC ++ G
Sbjct: 1310 QNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCED-G 1368

Query: 474  LVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLK 533
            L C + I +  +D  N  +  G+   + ++ ++   LN          L+++LK   G+ 
Sbjct: 1369 LTCSRKIIVAFQDQ-NIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKFQNGII 1427

Query: 534  ILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST 593
            +++     R+ + L   W  +  GLCG  NG+++DDF +    +        N+W+ S  
Sbjct: 1428 VIWD-KNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQE 1486

Query: 594  CFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGS 652
            C     V    PC+ N     +A   C+++    F  CH  + P  Y+ +C  +AC C  
Sbjct: 1487 CSDT--VAQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDM 1544

Query: 653  S----CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-------QKGMLYHHCSSFCLH 701
                   C A+A YA  C   GV + +R + + C V C       +    Y  C +    
Sbjct: 1545 EGKYLGFCTAVAMYAEACSAVGVCVSWR-KPNLCPVYCDYYNAPGECRWHYEPCGTVTAK 1603

Query: 702  SCISLSSPEQCSDDCAEGC--NCPEGKFY--EDTLNFCVPIFHCRCHYRGSVYQPGELIP 757
            +C      ++ S    EGC   CP+   Y  E+T+  CV +  C C Y   +   G +  
Sbjct: 1604 TCKDQLVGQKFS-SLLEGCYAKCPDSAPYLDENTMK-CVSLSECSCFYNDVIPAGGVIED 1661

Query: 758  TPSGLCQCSNGTVKCDELA 776
                 C C  G ++C E A
Sbjct: 1662 NCGRTCYCIAGQLECSETA 1680



 Score =  140 bits (352), Expect = 2e-32
 Identities = 112/375 (29%), Positives = 151/375 (40%), Gaps = 32/375 (8%)

Query: 63   ICKTWGQYHFETFDGIYYYFPGNCSYIFAKD-CGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            IC  +G+ H  TFDG  Y F G C Y F +D CG     + +   + P C   + +C R 
Sbjct: 1316 ICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCEDGL-TCSRK 1374

Query: 122  ISLFFSNQEEIRIYGHEIK-KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180
            I + F +Q  +   G     K+  S           I  +  Y+++K   G  + WD  +
Sbjct: 1375 IIVAFQDQNIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKFQNGIIVIWDKNT 1434

Query: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSV-QTPDDTKCVL 239
             + + L  +  GK CGLCGN N    DDF             F NSW   Q   DT    
Sbjct: 1435 RLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQT 1494

Query: 240  TPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETY 299
             P D    C +          KC+IL    F  CH  +DP  Y   C+ + C  D +  Y
Sbjct: 1495 FPCDSNPYCKAWAVR------KCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKY 1548

Query: 300  ---CRAATEYARACSHAGYPIQDWRDDFPACTDKCD-------DSFVHRDCISCCPPTCT 349
               C A   YA ACS  G  +  WR     C   CD         + +  C +    TC 
Sbjct: 1549 LGFCTAVAMYAEACSAVGVCV-SWRKP-NLCPVYCDYYNAPGECRWHYEPCGTVTAKTC- 1605

Query: 350  FEKQCLGSNL-HCLDGCY--CPDGL-VMDNGT--CISLENCPCGFHGLAYSVGSKIEQEC 403
             + Q +G      L+GCY  CPD    +D  T  C+SL  C C F+      G  IE  C
Sbjct: 1606 -KDQLVGQKFSSLLEGCYAKCPDSAPYLDENTMKCVSLSECSC-FYNDVIPAGGVIEDNC 1663

Query: 404  -TECVCVGGVWNCTE 417
               C C+ G   C+E
Sbjct: 1664 GRTCYCIAGQLECSE 1678



 Score =  113 bits (283), Expect = 2e-24
 Identities = 91/370 (24%), Positives = 150/370 (40%), Gaps = 35/370 (9%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            G CK  G     TFDG+ Y FPGNC ++   +       +++ V   P   G   +C  S
Sbjct: 856  GRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHN-----EDWSISVELRPCPSGQTGTCLNS 909

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKL------ADYILVKTTFGFSLA 175
            ++L  ++   +  Y        ++    +  G  + +K+      + Y+ V+T F   L 
Sbjct: 910  VTLLLNSSVPVDKYVFN-SDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQ 968

Query: 176  WD--GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
                 +  +Y+ +  +    + GLCG+YN+   DDF+  Q    +    FANSW + +  
Sbjct: 969  IQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMS-- 1026

Query: 234  DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQF--PFLSCHEYIDPYLYIASCVNDLC 291
                   P   P+ C S +   +     C ILL    P  SCH  ++P  Y   C    C
Sbjct: 1027 ------CPKGNPSSCIS-IEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTC 1079

Query: 292  KTDD-DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF 350
              ++  +  C     Y +AC+     I  WR     C   C    V +  +  C  +C  
Sbjct: 1080 TCENSQDCLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACNSSCRS 1137

Query: 351  ----EKQCLGSNLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTE 405
                ++ C   ++  +DGC CPD +  +N G C+    C C  +      G  I  +  +
Sbjct: 1138 LSERDRSCDVEDVP-VDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPGKLIHIDDNK 1196

Query: 406  CVCVGGVWNC 415
            CVC  G+  C
Sbjct: 1197 CVCRDGILLC 1206



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 82/377 (21%), Positives = 133/377 (35%), Gaps = 67/377 (17%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGR 1491
            C E  CP RC +    S+ TFDG          ++ V      I   +  C     PSG+
Sbjct: 849  CTEALCPGRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHNEDWSISVELRPC-----PSGQ 902

Query: 1492 ISGLCFKK----LNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
             +G C       LN + P+ K + N     V  D I     + S ++ I ++ S Y+   
Sbjct: 903  -TGTCLNSVTLLLNSSVPVDKYVFNSDGT-VTNDKIRNQGYYYSDKIQIFNASSSYLQVE 960

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGL 1607
                +     +  ++ ++     N  + T GLCG  N   +DD  M +  I+        
Sbjct: 961  TYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDF-MSSQNILEKTSQA-- 1017

Query: 1608 FIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI--------------FIPCHDKV 1653
            F  SWE+             +C + + S CI +   +                  CH  V
Sbjct: 1018 FANSWEM------------MSCPKGNPSSCISIEKEKFAERHCGILLDSSGPLASCHPIV 1065

Query: 1654 SPEDF---CEKMWINYTYFWNYECDALSAYVALC-NKFDICIQWRTPDYCSLSCPEGKEY 1709
            +P+ +   C+K         +  C  L  YV  C  K    + WRT   C  SCP G  +
Sbjct: 1066 NPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRT-GLCEHSCPSGLVF 1124

Query: 1710 QPCVRPCEAR---------------------TCLNQWFYGHTSCLNLREDCVCKVGTILH 1748
            +  V+ C +                      TC +  +  +     L+  C C +   + 
Sbjct: 1125 KYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVM 1184

Query: 1749 RPHSAQCIPEKECACTD 1765
            +P     I + +C C D
Sbjct: 1185 QPGKLIHIDDNKCVCRD 1201



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 79/365 (21%), Positives = 137/365 (37%), Gaps = 58/365 (15%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI-------PGEIIVAHIEKCSM 1484
            C + EC   C +  E  + TFDG + +   +  Y  +            I+   +  C  
Sbjct: 1308 CTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCED 1367

Query: 1485 NQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYV 1544
                S +I  + F+  N+     K+   +     + +        ++   SI   G   +
Sbjct: 1368 GLTCSRKII-VAFQDQNIVLQDGKVTAVKSTESKKCE-------LNANAYSIHTVGLYLI 1419

Query: 1545 ITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITN 1601
            +    G+I+ W   + L+ I+D       N +    GLCG  N D  DD   +  ++ + 
Sbjct: 1420 LKFQNGIIVIWDKNTRLSVILDP------NWNGKVCGLCGNNNGDLKDDFTTRYSSVASG 1473

Query: 1602 MEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS-----QCIDLLNRRIFIPCHDKVSPE 1656
              + G    SW+  +    T+ +     +   C      +C ++L    F  CH+KV P 
Sbjct: 1474 ALEFG---NSWKTSQECSDTVAQTFPCDSNPYCKAWAVRKC-EILRDSTFRDCHNKVDPS 1529

Query: 1657 ---DFCEK------MWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGK 1707
               D C +      M   Y  F    C A++ Y   C+   +C+ WR P+ C + C    
Sbjct: 1530 AYHDVCIEEACACDMEGKYLGF----CTAVAMYAEACSAVGVCVSWRKPNLCPVYCDYYN 1585

Query: 1708 -------EYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV--CKVGTILHRPHSAQCIPE 1758
                    Y+PC     A+TC +Q      S  +L E C   C         ++ +C+  
Sbjct: 1586 APGECRWHYEPC-GTVTAKTCKDQLVGQKFS--SLLEGCYAKCPDSAPYLDENTMKCVSL 1642

Query: 1759 KECAC 1763
             EC+C
Sbjct: 1643 SECSC 1647



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 26/57 (45%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDC 1332
            C W YEPC T   KTC D + +  KF   +EGC   CP +   LDE T+KCV   +C
Sbjct: 1590 CRWHYEPCGTVTAKTCKD-QLVGQKFSSLLEGCYAKCPDSAPYLDENTMKCVSLSEC 1645


>gi|239744587 PREDICTED: hypothetical protein XP_002343203 [Homo
            sapiens]
          Length = 2134

 Score =  400 bits (1027), Expect = e-110
 Identities = 255/942 (27%), Positives = 418/942 (44%), Gaps = 91/942 (9%)

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYI---DPYLYIASCVNDLCKTDDDE 297
            P D PN         E     C  ++   F  C +     + Y  I  C+++ C+T D  
Sbjct: 668  PGDCPNAVGKSYEVCEDGIQHCNKIIGTYFEKCGKVAALSNDYKMI--CIDEYCQTRDKT 725

Query: 298  TYCRAATEYARACSHAGY-PIQDWRDDFPAC--TDKCDDSFVHRDCISCCPPTCTFEKQC 354
            + C   +E +R C+  G    + WR D      T +C +  ++++C    P TC+     
Sbjct: 726  STCDTYSELSRLCASDGPGTFESWRSDSDVVCGTQRCPEQHIYKECGPSNPATCSNVAPF 785

Query: 355  LGSNLHCLDGCYCPDGLVMDN----GTCISLENCPCGFHGLAYSVGSKIEQEC-TECVCV 409
              S   C+ GC CP+G ++D+    G C+    CPC   G  Y  G   E  C ++C C 
Sbjct: 786  QDSE--CVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQ 843

Query: 410  GGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCE 469
               W+CTE  CP +C V G S  TTFDG  Y+F G C ++ V     + ++I+++  PC 
Sbjct: 844  DAKWSCTEALCPGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHN---EDWSISVELRPCP 899

Query: 470  QNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSP---NQGFNLNGIVEIQTLSSLFILL 526
                  CL S+TL+L         +      +T+    NQG+  +  ++I   SS ++ +
Sbjct: 900  SGQTGTCLNSVTLLLNSSVPVDKYVFNSDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQV 959

Query: 527  KTTFGLKILFAI-DGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHA 585
            +T F +K+   I    ++Y+ +       T+GLCG++N    DDF+S   ++E T Q  A
Sbjct: 960  ETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFA 1019

Query: 586  NAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQEL--FAPCHIYISPGLYYQLC 643
            N+W + S    P   P    C   ++      HC ++       A CH  ++P  Y++ C
Sbjct: 1020 NSWEMMS---CPKGNP--SSCISIEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEEC 1074

Query: 644  RHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVVCQKGMLYHHCSSFCL 700
            +   C C +S  CLC  L +Y   C +    I  +RT +  C   C  G+++ +    C 
Sbjct: 1075 KKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACN 1132

Query: 701  HSCISLSSPEQC---SDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIP 757
             SC SLS  ++     D   +GC CP+   Y++    CV    C C+    V QPG+LI 
Sbjct: 1133 SSCRSLSERDRSCDVEDVPVDGCTCPDA-MYQNNEGNCVLKSQCDCYINDEVMQPGKLIH 1191

Query: 758  TPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMN 817
                 C C +G + C ++     +  C  G EY DC  P  +          TC+   + 
Sbjct: 1192 IDDNKCVCRDGILLC-QIPIDLTLQNCSGGAEYVDCSDPKAQR-----RTNRTCSTRNIP 1245

Query: 818  FTCTPSSPCISGCVCAPGV-------------------------------------CRRG 840
                 + PC  GC C  G+                                     C +G
Sbjct: 1246 -VFDENLPCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVGCNECTCIKG 1304

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSA---DDSDISVIAQNKKC 897
             ++CT   C  +C IYG+ H  +FDG  Y +   CQ   ++     ++    ++ ++  C
Sbjct: 1305 SWSCTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPC 1364

Query: 898  FDNDIVCSKSVLISVGDTEIYLND---TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPE 954
             ++ + CS+ ++++  D  I L D   T  K  +S     N + Y +   G Y+++ F +
Sbjct: 1365 CEDGLTCSRKIIVAFQDQNIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKF-Q 1423

Query: 955  KDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL 1014
              I ++WD+ T + + + P W  K+ GLCGN +    +D TT  +     A  FG+SW  
Sbjct: 1424 NGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKT 1483

Query: 1015 GQ-CESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCN 1073
             Q C        PC+++     +A ++C IL    F  C N +D +++   C E+ C C+
Sbjct: 1484 SQECSDTVAQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACD 1543

Query: 1074 LGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
            + G     CT++A YA  C   G+ + WR   +C + C+YYN
Sbjct: 1544 MEGKYLGFCTAVAMYAEACSAVGVCVSWRKPNLCPVYCDYYN 1585



 Score =  207 bits (527), Expect = 9e-53
 Identities = 127/439 (28%), Positives = 201/439 (45%), Gaps = 28/439 (6%)

Query: 358  NLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCT 416
            NL C  GC+CP+G+V ++ G C+   +CPC F G  Y  GS     C EC C+ G W+CT
Sbjct: 1250 NLPCKRGCFCPEGMVRNSKGICVFPNDCPCSFGGREYDEGSVTSVGCNECTCIKGSWSCT 1309

Query: 417  EQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK---GTGKDKFTITLQKAPCEQNLG 473
            + +C   C + G+ H  TFDG+ YSF G+CQY  ++   G     F I  +  PC ++ G
Sbjct: 1310 QNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCED-G 1368

Query: 474  LVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLK 533
            L C + I +  +D  N  +  G+   + ++ ++   LN          L+++LK   G+ 
Sbjct: 1369 LTCSRKIIVAFQDQ-NIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKFQNGII 1427

Query: 534  ILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST 593
            +++     R+ + L   W  +  GLCG  NG+++DDF +    +        N+W+ S  
Sbjct: 1428 VIWD-KNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQE 1486

Query: 594  CFAPVHVPVVDPCNINQQNIGYAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGS 652
            C     V    PC+ N     +A   C+++    F  CH  + P  Y+ +C  +AC C  
Sbjct: 1487 CSDT--VAQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDM 1544

Query: 653  S----CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-------QKGMLYHHCSSFCLH 701
                   C A+A YA  C   GV + +R + + C V C       +    Y  C +    
Sbjct: 1545 EGKYLGFCTAVAMYAEACSAVGVCVSWR-KPNLCPVYCDYYNAPGECRWHYEPCGTVTAK 1603

Query: 702  SCISLSSPEQCSDDCAEGC--NCPEGKFY--EDTLNFCVPIFHCRCHYRGSVYQPGELIP 757
            +C      ++ S    EGC   CP+   Y  E+T+  CV +  C C Y   +   G +  
Sbjct: 1604 TCKDQLVGQKFS-SLLEGCYAKCPDSAPYLDENTMK-CVSLSECSCFYNDVIPAGGVIED 1661

Query: 758  TPSGLCQCSNGTVKCDELA 776
                 C C  G ++C E A
Sbjct: 1662 NCGRTCYCIAGQLECSETA 1680



 Score =  140 bits (352), Expect = 2e-32
 Identities = 112/375 (29%), Positives = 151/375 (40%), Gaps = 32/375 (8%)

Query: 63   ICKTWGQYHFETFDGIYYYFPGNCSYIFAKD-CGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            IC  +G+ H  TFDG  Y F G C Y F +D CG     + +   + P C   + +C R 
Sbjct: 1316 ICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCEDGL-TCSRK 1374

Query: 122  ISLFFSNQEEIRIYGHEIK-KNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGIS 180
            I + F +Q  +   G     K+  S           I  +  Y+++K   G  + WD  +
Sbjct: 1375 IIVAFQDQNIVLQDGKVTAVKSTESKKCELNANAYSIHTVGLYLILKFQNGIIVIWDKNT 1434

Query: 181  GIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSV-QTPDDTKCVL 239
             + + L  +  GK CGLCGN N    DDF             F NSW   Q   DT    
Sbjct: 1435 RLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQT 1494

Query: 240  TPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETY 299
             P D    C +          KC+IL    F  CH  +DP  Y   C+ + C  D +  Y
Sbjct: 1495 FPCDSNPYCKAWAVR------KCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKY 1548

Query: 300  ---CRAATEYARACSHAGYPIQDWRDDFPACTDKCD-------DSFVHRDCISCCPPTCT 349
               C A   YA ACS  G  +  WR     C   CD         + +  C +    TC 
Sbjct: 1549 LGFCTAVAMYAEACSAVGVCV-SWRKP-NLCPVYCDYYNAPGECRWHYEPCGTVTAKTC- 1605

Query: 350  FEKQCLGSNL-HCLDGCY--CPDGL-VMDNGT--CISLENCPCGFHGLAYSVGSKIEQEC 403
             + Q +G      L+GCY  CPD    +D  T  C+SL  C C F+      G  IE  C
Sbjct: 1606 -KDQLVGQKFSSLLEGCYAKCPDSAPYLDENTMKCVSLSECSC-FYNDVIPAGGVIEDNC 1663

Query: 404  -TECVCVGGVWNCTE 417
               C C+ G   C+E
Sbjct: 1664 GRTCYCIAGQLECSE 1678



 Score =  113 bits (283), Expect = 2e-24
 Identities = 91/370 (24%), Positives = 150/370 (40%), Gaps = 35/370 (9%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            G CK  G     TFDG+ Y FPGNC ++   +       +++ V   P   G   +C  S
Sbjct: 856  GRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHN-----EDWSISVELRPCPSGQTGTCLNS 909

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKL------ADYILVKTTFGFSLA 175
            ++L  ++   +  Y        ++    +  G  + +K+      + Y+ V+T F   L 
Sbjct: 910  VTLLLNSSVPVDKYVFN-SDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQ 968

Query: 176  WD--GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
                 +  +Y+ +  +    + GLCG+YN+   DDF+  Q    +    FANSW + +  
Sbjct: 969  IQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMS-- 1026

Query: 234  DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQF--PFLSCHEYIDPYLYIASCVNDLC 291
                   P   P+ C S +   +     C ILL    P  SCH  ++P  Y   C    C
Sbjct: 1027 ------CPKGNPSSCIS-IEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTC 1079

Query: 292  KTDD-DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF 350
              ++  +  C     Y +AC+     I  WR     C   C    V +  +  C  +C  
Sbjct: 1080 TCENSQDCLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACNSSCRS 1137

Query: 351  ----EKQCLGSNLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTE 405
                ++ C   ++  +DGC CPD +  +N G C+    C C  +      G  I  +  +
Sbjct: 1138 LSERDRSCDVEDVP-VDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPGKLIHIDDNK 1196

Query: 406  CVCVGGVWNC 415
            CVC  G+  C
Sbjct: 1197 CVCRDGILLC 1206



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 82/377 (21%), Positives = 133/377 (35%), Gaps = 67/377 (17%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGR 1491
            C E  CP RC +    S+ TFDG          ++ V      I   +  C     PSG+
Sbjct: 849  CTEALCPGRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHNEDWSISVELRPC-----PSGQ 902

Query: 1492 ISGLCFKK----LNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
             +G C       LN + P+ K + N     V  D I     + S ++ I ++ S Y+   
Sbjct: 903  -TGTCLNSVTLLLNSSVPVDKYVFNSDGT-VTNDKIRNQGYYYSDKIQIFNASSSYLQVE 960

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGL 1607
                +     +  ++ ++     N  + T GLCG  N   +DD  M +  I+        
Sbjct: 961  TYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDF-MSSQNILEKTSQA-- 1017

Query: 1608 FIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI--------------FIPCHDKV 1653
            F  SWE+             +C + + S CI +   +                  CH  V
Sbjct: 1018 FANSWEM------------MSCPKGNPSSCISIEKEKFAERHCGILLDSSGPLASCHPIV 1065

Query: 1654 SPEDF---CEKMWINYTYFWNYECDALSAYVALC-NKFDICIQWRTPDYCSLSCPEGKEY 1709
            +P+ +   C+K         +  C  L  YV  C  K    + WRT   C  SCP G  +
Sbjct: 1066 NPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRT-GLCEHSCPSGLVF 1124

Query: 1710 QPCVRPCEAR---------------------TCLNQWFYGHTSCLNLREDCVCKVGTILH 1748
            +  V+ C +                      TC +  +  +     L+  C C +   + 
Sbjct: 1125 KYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVM 1184

Query: 1749 RPHSAQCIPEKECACTD 1765
            +P     I + +C C D
Sbjct: 1185 QPGKLIHIDDNKCVCRD 1201



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 79/365 (21%), Positives = 137/365 (37%), Gaps = 58/365 (15%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI-------PGEIIVAHIEKCSM 1484
            C + EC   C +  E  + TFDG + +   +  Y  +            I+   +  C  
Sbjct: 1308 CTQNECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCED 1367

Query: 1485 NQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYV 1544
                S +I  + F+  N+     K+   +     + +        ++   SI   G   +
Sbjct: 1368 GLTCSRKII-VAFQDQNIVLQDGKVTAVKSTESKKCE-------LNANAYSIHTVGLYLI 1419

Query: 1545 ITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITN 1601
            +    G+I+ W   + L+ I+D       N +    GLCG  N D  DD   +  ++ + 
Sbjct: 1420 LKFQNGIIVIWDKNTRLSVILDP------NWNGKVCGLCGNNNGDLKDDFTTRYSSVASG 1473

Query: 1602 MEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS-----QCIDLLNRRIFIPCHDKVSPE 1656
              + G    SW+  +    T+ +     +   C      +C ++L    F  CH+KV P 
Sbjct: 1474 ALEFG---NSWKTSQECSDTVAQTFPCDSNPYCKAWAVRKC-EILRDSTFRDCHNKVDPS 1529

Query: 1657 ---DFCEK------MWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGK 1707
               D C +      M   Y  F    C A++ Y   C+   +C+ WR P+ C + C    
Sbjct: 1530 AYHDVCIEEACACDMEGKYLGF----CTAVAMYAEACSAVGVCVSWRKPNLCPVYCDYYN 1585

Query: 1708 -------EYQPCVRPCEARTCLNQWFYGHTSCLNLREDCV--CKVGTILHRPHSAQCIPE 1758
                    Y+PC     A+TC +Q      S  +L E C   C         ++ +C+  
Sbjct: 1586 APGECRWHYEPC-GTVTAKTCKDQLVGQKFS--SLLEGCYAKCPDSAPYLDENTMKCVSL 1642

Query: 1759 KECAC 1763
             EC+C
Sbjct: 1643 SECSC 1647



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 26/57 (45%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDC 1332
            C W YEPC T   KTC D + +  KF   +EGC   CP +   LDE T+KCV   +C
Sbjct: 1590 CRWHYEPCGTVTAKTCKD-QLVGQKFSSLLEGCYAKCPDSAPYLDENTMKCVSLSEC 1645


>gi|239749951 PREDICTED: similar to mucin 2 [Homo sapiens]
          Length = 2639

 Score =  337 bits (864), Expect = 8e-92
 Identities = 197/652 (30%), Positives = 322/652 (49%), Gaps = 70/652 (10%)

Query: 520  SSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIE 578
            SS  I++    G+++   +    ++++ L  A + +  GLCG FNG   DDF + SG++E
Sbjct: 389  SSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGLVE 448

Query: 579  GTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH-CDVIH--QELFAPCHIYIS 635
             T    AN W+  S+C   +   + DPC++N ++  YA H C ++   +  F  CH  + 
Sbjct: 449  ATGAGFANTWKAQSSCHDKLDW-LDDPCSLNIESANYAEHWCSLLKKTETPFGRCHSAVD 507

Query: 636  PGLYYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAV-VCQKGML 691
            P  YY+ C++D C C ++  CLC AL+ YA  C   GV +  +R  +    V  C    +
Sbjct: 508  PAEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQV 567

Query: 692  YHHCSSFCLHSCISLSSPEQ-CSDDCA--EGCNCPEGKFYEDTLNFCVPIFHCRCHYRGS 748
            + +  + C  +C SLS  +  C +  A  +GC CP+  F ++    CVP+  C C++RG 
Sbjct: 568  FLYNLTTCQQTCRSLSEADSHCLEGFAPVDGCGCPDHTFLDEK-GRCVPLAKCSCYHRGL 626

Query: 749  VYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCE 808
              + G+++      C C +G + C ++        C   K + DC   +    A      
Sbjct: 627  YLEAGDVVVRQEERCVCRDGRLHCRQIRLIG--QSCTAPKIHMDCS--NLTALATSKPRA 682

Query: 809  TTCANLAMNFTCTPSSPCISGCVCAPGV-------------------------------- 836
             +C  LA  +  T    C+SGCVC  G+                                
Sbjct: 683  LSCQTLAAGYYHTE---CVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVD 739

Query: 837  -----CRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK-----SADDS 886
                 C+RG + CT   C   C+IYG  HY +FDG  YD+   C    ++     ++   
Sbjct: 740  CNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLG 799

Query: 887  DISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYK--QKQSGFFLENKSTYQLWKA 944
              S+I +N  C    + CSK++ I +G TE+ L D      Q+  G  +     Y   + 
Sbjct: 800  SFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHV----AYTTREV 855

Query: 945  GYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRN 1004
            G Y+VV      I ++WD++TT+ IK+ P +K  + GLCGNFD  ++ND TT +++ V +
Sbjct: 856  GQYLVVE-SSTGIIVIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSS 914

Query: 1005 ARVFGDSWALGQ-CESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAK 1063
               FG+SW     C       +PC  + ++  +A+K+CSIL S +F+ C + +D   F +
Sbjct: 915  ELDFGNSWKEAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYE 974

Query: 1064 NCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYN 1115
             C  D+C+C+ GGDCEC C+++A+YA +C +EG  + WR+  +C + C+YYN
Sbjct: 975  ACVHDSCSCDTGGDCECFCSAVASYAQECTKEGACVFWRTPDLCPIFCDYYN 1026



 Score =  202 bits (513), Expect = 4e-51
 Identities = 118/433 (27%), Positives = 207/433 (47%), Gaps = 35/433 (8%)

Query: 361  CLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQD 419
            C+ GC CPDGL+ D  G C+  + CPC  +   YS G+KI+ +C  C C  G W CT+  
Sbjct: 697  CVSGCVCPDGLMDDGRGGCVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAV 756

Query: 420  CPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV-----KGTGKDKFTITLQKAPCEQNLGL 474
            C   CS+ G  H+ TFDG++Y F G C Y+ V     + +    F+I  +  PC    G+
Sbjct: 757  CHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVPC-GTTGV 815

Query: 475  VCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKI 534
             C ++I + +      ++ L    +++   ++G +   +         +++++++ G+ +
Sbjct: 816  TCSKAIKIFMG---RTELKLEDKHRVVIQRDEGHH---VAYTTREVGQYLVVESSTGIIV 869

Query: 535  LFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTC 594
            ++      ++I+L  ++K    GLCG F+    +DF +   M+  +     N+W+ + TC
Sbjct: 870  IWD-KRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTC 928

Query: 595  FAPVHVPVVDPCNINQQNIGYA-AHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGS- 652
              P      +PC++N     +A   C ++   +F+ CH  + P  +Y+ C HD+C C + 
Sbjct: 929  --PDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACVHDSCSCDTG 986

Query: 653  ---SCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-------QKGMLYHHCSSFCLHS 702
                C C+A+A YA  C + G  + +RT    C + C       +    Y  C +    +
Sbjct: 987  GDCECFCSAVASYAQECTKEGACVFWRTP-DLCPIFCDYYNPPHECEWHYEPCGNRSFET 1045

Query: 703  CISLSS-PEQCSDDCAEGC--NCPEGK-FYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT 758
            C +++      S    EGC   CP+ +  YE+ L  CV    C C+   + Y PG  +PT
Sbjct: 1046 CRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASVPT 1105

Query: 759  PSGL--CQCSNGT 769
                  C C+N +
Sbjct: 1106 EETCKSCVCTNSS 1118



 Score =  172 bits (435), Expect = 4e-42
 Identities = 131/485 (27%), Positives = 214/485 (44%), Gaps = 46/485 (9%)

Query: 1414 MPDCGFRGRPVQVNS-DICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILV-RIP 1471
            MP C    +PV+V   D CC  WEC C C+   +   +TFDG   +     +Y+LV  I 
Sbjct: 1913 MPTCSNGLQPVRVEDPDGCCWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEIS 1972

Query: 1472 GEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNR-----LARKVEVDSIVVP 1526
              +    +   + +  P+ ++S  C + L V     ++++       +  +V+V+   V 
Sbjct: 1973 PSVDNFGVYIDNYHCDPNDKVS--CPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVA 2030

Query: 1527 LPFSSQELSIEDSGSMYVITTP-AGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNE 1585
            LP+    L +  SG  YV+  P  G+++ ++ L+  + + +       + T+G CG C  
Sbjct: 2031 LPYKKYGLEVYQSGINYVVDIPELGVLVSYNGLSFSVRLPY---HRFGNNTKGQCGTCTN 2087

Query: 1586 DPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE-------VTMRRPV-------RNCTE 1631
               DD  + +G I++N E      + W +    +        T +RP        +    
Sbjct: 2088 TTSDDCILPSGEIVSNCEAAA---DQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPH 2144

Query: 1632 HDC--SQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYF--WNYECDALSAYVALCNKF 1687
             DC  S    L+   +F  CH  V P+ + +    +  +    + EC +L AY ALC + 
Sbjct: 2145 KDCTPSPLCQLIKDSLFAQCHALVPPQHYYDACVFDSCFMPGSSLECASLQAYAALCAQQ 2204

Query: 1688 DICIQWR--TPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGT 1745
            +IC+ WR  T   C + CP  +EYQ C  P E  TC +     + +   L E C C  GT
Sbjct: 2205 NICLDWRNHTHGACLVECPSHREYQAC-GPAEEPTCKSSSSQQNNTV--LVEGCFCPEGT 2261

Query: 1746 ILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPD-CDE 1804
            + + P    C+  K C C   ++ PR  GE +      C    CLE GS I  +P  C +
Sbjct: 2262 MNYAPGFDVCV--KTCGCVGPDNVPREFGEHFEFDCKNCV---CLEGGSGIICQPKRCSQ 2316

Query: 1805 EPTPVCEREAEVVMGIIDKW-TCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCP 1863
            +P   C  +   +   ++   TCC+  VC C+T+LC+     C    ++     P  CCP
Sbjct: 2317 KPVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLGFEVKSKMVPGRCCP 2376

Query: 1864 QYKCE 1868
             Y CE
Sbjct: 2377 FYWCE 2381



 Score =  134 bits (338), Expect = 8e-31
 Identities = 103/373 (27%), Positives = 162/373 (43%), Gaps = 43/373 (11%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKD-CGDLEP--RYTVWVHNSPKCLGSVYSC 118
            G C  +G  H+ TFDG YY F G+CSY+  +D CG       +++   N P C  +  +C
Sbjct: 759  GTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVP-CGTTGVTC 817

Query: 119  YRSISLFFSNQE-----EIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFS 173
             ++I +F    E     + R+     + + ++ T  + +GQ        Y++V+++ G  
Sbjct: 818  SKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTRE-VGQ--------YLVVESSTGII 868

Query: 174  LAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
            + WD  + +++KL+  +KG  CGLCGN++   ++DF             F NSW      
Sbjct: 869  VIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWK----- 923

Query: 234  DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKT 293
            +       S  P PCS           +C IL    F  CH  +DP  +  +CV+D C  
Sbjct: 924  EAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACVHDSCSC 983

Query: 294  D---DDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPP--TC 348
            D   D E +C A   YA+ C+  G  +  WR     C   CD      +C     P    
Sbjct: 984  DTGGDCECFCSAVASYAQECTKEGACV-FWRTP-DLCPIFCDYYNPPHECEWHYEPCGNR 1041

Query: 349  TFEKQCLGSNLHC------LDGCY--CPDGLVM---DNGTCISLENCPCGFHGLAYSVGS 397
            +FE     + +H       L+GCY  CP    +   D   C++ + C C      Y  G+
Sbjct: 1042 SFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGA 1101

Query: 398  KI--EQECTECVC 408
             +  E+ C  CVC
Sbjct: 1102 SVPTEETCKSCVC 1114



 Score =  134 bits (337), Expect = 1e-30
 Identities = 93/337 (27%), Positives = 140/337 (41%), Gaps = 22/337 (6%)

Query: 47  GTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVH 106
           G+  Q      N    +C TWG +H++TFDG  + FPG C Y FA DC      + V + 
Sbjct: 20  GSELQTEGRTRNHGHNVCSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRGSYKEFAVHLK 79

Query: 107 NSP---KCLGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADY 163
             P   +    V S   +I       + I +  H    NG  ++ P     + IEK   Y
Sbjct: 80  RGPGQAEAPAGVESILLTI-----KDDTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAY 134

Query: 164 ILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQS-DDFIILQEDYTEDIAM 222
             V +  G +L W+    + L+L    +  +CGLCG+YN +QS  +F  L +        
Sbjct: 135 TKVYSRAGLTLMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEF--LSDGVLFSPLE 192

Query: 223 FANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLY 282
           F N   +  PD           P  CS      E      ++L    F  C + +    Y
Sbjct: 193 FGNMQKINQPDVVCEDPEEEVAPASCSEHRAECE------RLLTAEAFADCQDLVPLEPY 246

Query: 283 IASCVNDLCKTDDDET-YCRAATEYARACSHAGYPIQDWRDD----FPACTDKCDDSFVH 337
           + +C  D C+    +T  C    E++R CSHAG    +WR       P  +  C  + V+
Sbjct: 247 LRACQQDRCRCPGGDTCVCSTVAEFSRQCSHAGGRPGNWRTATSAVSPGASKTCPGNLVY 306

Query: 338 RDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMD 374
            +  S C  TC+  +       H +DGC+CP+G   D
Sbjct: 307 LESGSPCMDTCSHLEVSSLCEEHRMDGCFCPEGAQAD 343



 Score =  128 bits (321), Expect = 7e-29
 Identities = 135/518 (26%), Positives = 185/518 (35%), Gaps = 93/518 (17%)

Query: 415  CTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK--GTGKDKFTITLQKAPCEQNL 472
            C   +C   C+  GD H+ TFDG +YS+ G C Y+LV+      D F + +    C+ N 
Sbjct: 1932 CWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPND 1991

Query: 473  GLVCLQSITLILEDD-----------FNKQVTLGRGGQILTSPNQGF-----NLNGIVEI 516
             + C +++ +  E                QV + R    L     G       +N +V+I
Sbjct: 1992 KVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDI 2051

Query: 517  QTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGM 576
              L  L      +F +++ +   G              T G CGT      DD + PSG 
Sbjct: 2052 PELGVLVSYNGLSFSVRLPYHRFG------------NNTKGQCGTCTNTTSDDCILPSGE 2099

Query: 577  IEGTPQLHANAWRV-----------SSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQE 625
            I    +  A+ W V           SST   P             ++   +  C +I   
Sbjct: 2100 IVSNCEAAADQWLVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTPSPLCQLIKDS 2159

Query: 626  LFAPCHIYISPGLYYQLCRHDAC-KCGSSCLCNALAHYAYLCGQHGVPIDFRTQI-SFCA 683
            LFA CH  + P  YY  C  D+C   GSS  C +L  YA LC Q  + +D+R      C 
Sbjct: 2160 LFAQCHALVPPQHYYDACVFDSCFMPGSSLECASLQAYAALCAQQNICLDWRNHTHGACL 2219

Query: 684  VVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKF-YEDTLNFCVPIF--- 739
            V C     Y  C      +C S SS +Q +    EGC CPEG   Y    + CV      
Sbjct: 2220 VECPSHREYQACGPAEEPTCKS-SSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCV 2278

Query: 740  ------------------HCRCHYRGS--VYQPGELIPTPSGLC---------------Q 764
                              +C C   GS  + QP      P   C                
Sbjct: 2279 GPDNVPREFGEHFEFDCKNCVCLEGGSGIICQPKRCSQKPVTHCVEDGTYLATEVNPADT 2338

Query: 765  CSNGTV-KCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPS 823
            C N TV KC+         +CP G E      P    P     CE+    +  N    P 
Sbjct: 2339 CCNITVCKCNTSLCKEKPSVCPLGFEVKSKMVPGRCCPF--YWCESKGVCVHGNAEYQPG 2396

Query: 824  SPCISG----CVCAPGVCRRGMFN---CTYYPCPAVCT 854
            SP  S     CVC   V    + N   CT+ PC   C+
Sbjct: 2397 SPVYSSKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCS 2434



 Score =  122 bits (306), Expect = 4e-27
 Identities = 103/412 (25%), Positives = 161/412 (39%), Gaps = 42/412 (10%)

Query: 32  CSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFA 91
           C    TC C        +C    +   GR G    W         G     PGN  Y+ +
Sbjct: 257 CPGGDTCVCSTVAEFSRQC----SHAGGRPG---NWRTATSAVSPGASKTCPGNLVYLES 309

Query: 92  KD-----CGDLEPRYTVWVHNSPKCL---GSVYSCYRSISLFFSNQEEIRIYGHE--IKK 141
                  C  LE       H    C    G+     +++ L    ++ + ++  +  +  
Sbjct: 310 GSPCMDTCSHLEVSSLCEEHRMDGCFCPEGAQADLPKTVVLLADKKKNVVVFKSDGSVLL 369

Query: 142 NGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWD--GISGIYLKLSEDHKGKSCGLC 198
           N + + LP       + + + Y I+V    G  L      +  +++ L +  +G+  GLC
Sbjct: 370 NELQVNLPHVTASFSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLC 429

Query: 199 GNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAI 258
           GN+N ++ DDF           A FAN+W  Q+    K         +PCS  + +    
Sbjct: 430 GNFNGLEGDDFKTASGLVEATGAGFANTWKAQSSCHDKL----DWLDDPCSLNIESANYA 485

Query: 259 FFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET-YCRAATEYARACSHAGY 315
              C +L   + PF  CH  +DP  Y   C  D C   ++E   C A + YARAC+  G 
Sbjct: 486 EHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSSYARACTAKGV 545

Query: 316 PIQDWRDDFPACTD---KCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCL------DGCY 366
            +  WR+    C      C +S V    ++ C  TC   +    ++ HCL      DGC 
Sbjct: 546 MLWGWREH--VCNKDVGSCPNSQVFLYNLTTCQQTC---RSLSEADSHCLEGFAPVDGCG 600

Query: 367 CPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTE 417
           CPD   +D  G C+ L  C C   GL    G  + ++   CVC  G  +C +
Sbjct: 601 CPDHTFLDEKGRCVPLAKCSCYHRGLYLEAGDVVVRQEERCVCRDGRLHCRQ 652



 Score =  122 bits (306), Expect = 4e-27
 Identities = 93/372 (25%), Positives = 156/372 (41%), Gaps = 27/372 (7%)

Query: 61   DGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYR 120
            D  C  WG  H+ TFDG+YY + GNC+Y+  ++       + V++ N         SC R
Sbjct: 1938 DCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPNDKVSCPR 1997

Query: 121  SISLFFSNQEEIRIYGH------EIKKNGISLTLP-QTIGQIFIEKLADYILVKTTFGFS 173
            ++ +    QE +    H      +++ N  ++ LP +  G    +   +Y++     G  
Sbjct: 1998 TLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDIPELGVL 2057

Query: 174  LAWDGISGIYLKLSEDHKGKSC-GLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTP 232
            ++++G+S   ++L     G +  G CG   +  SDD I+   +   +    A+ W V  P
Sbjct: 2058 VSYNGLS-FSVRLPYHRFGNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQWLVNDP 2116

Query: 233  DDTKCVLTPSDFPNPCSSGMPAFEAIFFK-------CQILLQFPFLSCHEYIDPYLYIAS 285
                C  + S    P  +     +    K       CQ++    F  CH  + P  Y  +
Sbjct: 2117 SKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTPSPLCQLIKDSLFAQCHALVPPQHYYDA 2176

Query: 286  CVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRD-DFPACTDKCDDSFVHRDCISCC 344
            CV D C        C +   YA  C+     + DWR+    AC  +C     HR+  +C 
Sbjct: 2177 CVFDSCFMPGSSLECASLQAYAALCAQQNICL-DWRNHTHGACLVECPS---HREYQACG 2232

Query: 345  P---PTCTFEKQCLGSNLHCLDGCYCPDGLV-MDNGTCISLENCPC-GFHGLAYSVGSKI 399
            P   PTC        +N   ++GC+CP+G +    G  + ++ C C G   +    G   
Sbjct: 2233 PAEEPTCK-SSSSQQNNTVLVEGCFCPEGTMNYAPGFDVCVKTCGCVGPDNVPREFGEHF 2291

Query: 400  EQECTECVCVGG 411
            E +C  CVC+ G
Sbjct: 2292 EFDCKNCVCLEG 2303



 Score =  107 bits (267), Expect = 1e-22
 Identities = 87/354 (24%), Positives = 127/354 (35%), Gaps = 55/354 (15%)

Query: 1903 CVCESCT-KPVPLC-HDGEFLTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKE 1960
            C  + C+ KPV  C  DG +L  ++N    CC    C C  +LC      C     +  +
Sbjct: 2309 CQPKRCSQKPVTHCVEDGTYLATEVNPADTCCNITVCKCNTSLCKEKPSVCPLGFEVKSK 2368

Query: 1961 NVSGQCCPTWHCECNCENLVMPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSV 2020
             V G+CCP                                    Y CE   VCV      
Sbjct: 2369 MVPGRCCPF-----------------------------------YWCESKGVCVHGNAEY 2393

Query: 2021 LNPGQSMIKYLEEDFCYTIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGC 2080
              PG  +        C    C ++ DN+T  + +  T V C+  C        +P +  C
Sbjct: 2394 -QPGSPVYS----SKCQDCVCTDKVDNNTLLNVIACTHVPCNTSCSPGFELMEAPGE--C 2446

Query: 2081 CGTCKNVSCKFHMENGTSVVYAVG---STWHYNCTTYECVKTDEGAIILNYTMVCPPFNE 2137
            C  C+   C     +   V+   G   S    NCT + CVK     I     + CP F+ 
Sbjct: 2447 CKKCEQTHCIIKRPDNQHVILKPGDFKSDPKNNCTFFSCVKIHNQLISSVSNITCPNFDA 2506

Query: 2138 TECKMNEGIVKLYNEGCCKIC--KREERI-CQKVIIKSVIRKQDCMSQSPINVASCDGKC 2194
            + C    G +     GCCK C  + E R+ C  V + + +    C     +N   C G C
Sbjct: 2507 SICI--PGSITFMPNGCCKTCTPRNETRVPCSTVPVTTEVSYAGCTKTVLMN--HCSGSC 2562

Query: 2195 PSATIYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTCQ 2248
             +  +Y+   ++    C CC+E       V L C  NG  + +T      C CQ
Sbjct: 2563 GTFVMYSAKAQALDHSCSCCKEEKTSQREVVLSCP-NGGSLTHTYTHIESCQCQ 2615



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 81/322 (25%), Positives = 150/322 (46%), Gaps = 39/322 (12%)

Query: 424 CSVVGDSHFTTFDGRHYSFIGMCQYILV---KGTGKDKFTITLQKAPCEQNLGLVCLQSI 480
           CS  G+ H+ TFDG  + F G+C Y      +G+ K+ F + L++ P +       ++SI
Sbjct: 37  CSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRGSYKE-FAVHLKRGPGQAEAP-AGVESI 94

Query: 481 TLILEDDFNKQVTLGR-----GGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKIL 535
            L ++DD    + L R      G ++++P+    L  ++E    S  +  + +  GL ++
Sbjct: 95  LLTIKDD---TIYLTRHLAVLNGAVVSTPHYSPGL--LIE---KSDAYTKVYSRAGLTLM 146

Query: 536 FAIDGERIYIQLTSAWKRRTLGLCGTFNG-NIRDDFLSPSGMIEGTPQLHANAWRVSS-- 592
           +  + + + ++L + ++  T GLCG +NG     +FLS   +   +P    N  +++   
Sbjct: 147 WNRE-DALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGVLF--SPLEFGNMQKINQPD 203

Query: 593 -TCFAPVHVPVVDPCNINQQNIGYAAHCD-VIHQELFAPCHIYISPGLYYQLCRHDACKC 650
             C  P        C+ ++      A C+ ++  E FA C   +    Y + C+ D C+C
Sbjct: 204 VVCEDPEEEVAPASCSEHR------AECERLLTAEAFADCQDLVPLEPYLRACQQDRCRC 257

Query: 651 --GSSCLCNALAHYAYLCGQHGV-PIDFRTQISF----CAVVCQKGMLYHHCSSFCLHSC 703
             G +C+C+ +A ++  C   G  P ++RT  S      +  C   ++Y    S C+ +C
Sbjct: 258 PGGDTCVCSTVAEFSRQCSHAGGRPGNWRTATSAVSPGASKTCPGNLVYLESGSPCMDTC 317

Query: 704 ISLSSPEQCSDDCAEGCNCPEG 725
             L     C +   +GC CPEG
Sbjct: 318 SHLEVSSLCEEHRMDGCFCPEG 339



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 76/307 (24%), Positives = 121/307 (39%), Gaps = 33/307 (10%)

Query: 844  CTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDS--DISVIAQNKKCFDND 901
            C ++ C   CT +GD HY +FDGL Y Y  +C   L++    S  +  V   N  C  ND
Sbjct: 1932 CWHWECDCYCTGWGDPHYVTFDGLYYSYQGNCTYVLVEEISPSVDNFGVYIDNYHCDPND 1991

Query: 902  IVCSKSVLISVGDTEIYLNDTPYKQ---------KQSGFFLENKSTYQLWKAGYYIVVYF 952
             V     LI   +T+  L  T +           +Q+      K   +++++G   VV  
Sbjct: 1992 KVSCPRTLIVRHETQEVLIKTVHMMPMQVQVQVNRQAVALPYKKYGLEVYQSGINYVVDI 2051

Query: 953  PEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW 1012
            PE  + + ++  +        ++ N   G CG     TS+D    +   V N     D W
Sbjct: 2052 PELGVLVSYNGLSFSVRLPYHRFGNNTKGQCGTCTNTTSDDCILPSGEIVSNCEAAADQW 2111

Query: 1013 ALGQCESP------DETIKPCEA---------HQNKFPYAKKECSILYSDIFASCRNVID 1057
             +     P        T +P            H++  P     C ++   +FA C  ++ 
Sbjct: 2112 LVNDPSKPHCPHSSSTTKRPAVTVPGGGKTTPHKDCTP--SPLCQLIKDSLFAQCHALVP 2169

Query: 1058 VTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSST--VCSLDCEYYN 1115
               +   C  D+C    G   EC   S+ AYA  C Q+ I + WR+ T   C ++C  + 
Sbjct: 2170 PQHYYDACVFDSCFMP-GSSLEC--ASLQAYAALCAQQNICLDWRNHTHGACLVECPSHR 2226

Query: 1116 EGLGEGP 1122
            E    GP
Sbjct: 2227 EYQACGP 2233



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 63/279 (22%), Positives = 129/279 (46%), Gaps = 50/279 (17%)

Query: 852  VCTIYGDRHYYSFDG--------LEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIV 903
            VC+ +G+ HY +FDG         +Y++ SDC+          + +V  +          
Sbjct: 36   VCSTWGNFHYKTFDGDVFRFPGLCDYNFASDCR------GSYKEFAVHLKRGPGQAEAPA 89

Query: 904  CSKSVLISVGDTEIYLN-----------DTPYKQKQSGFFLENKSTYQLWKAGYYIVVYF 952
              +S+L+++ D  IYL             TP+     G  +E    Y            +
Sbjct: 90   GVESILLTIKDDTIYLTRHLAVLNGAVVSTPHYSP--GLLIEKSDAY---------TKVY 138

Query: 953  PEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW 1012
                +T++W+R+  + +++  +++N   GLCG+++   S     S+ + + +   FG+  
Sbjct: 139  SRAGLTLMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGV-LFSPLEFGNMQ 197

Query: 1013 ALGQ----CESPDETIKPCEAHQNKFPYAKKECS-ILYSDIFASCRNVIDVTSFAKNCHE 1067
             + Q    CE P+E + P    +++      EC  +L ++ FA C++++ +  + + C +
Sbjct: 198  KINQPDVVCEDPEEEVAPASCSEHR-----AECERLLTAEAFADCQDLVPLEPYLRACQQ 252

Query: 1068 DTCNCNLGGDCECLCTSIAAYAYKCCQE-GISIHWRSST 1105
            D C C  GGD  C+C+++A ++ +C    G   +WR++T
Sbjct: 253  DRCRCP-GGD-TCVCSTVAEFSRQCSHAGGRPGNWRTAT 289



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 97/463 (20%), Positives = 157/463 (33%), Gaps = 90/463 (19%)

Query: 1421 GRPVQVNSDIC--------CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPG 1472
            G  ++V+ + C        C +  C   CS+      ITFDG         SY+ V+   
Sbjct: 733  GAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQ--- 789

Query: 1473 EIIVAHIEKCSMNQA-----------PSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVD 1521
                   + C  N +           P G     C K +       KI + R   K+E  
Sbjct: 790  -------DYCGQNSSLGSFSIITENVPCGTTGVTCSKAI-------KIFMGRTELKLEDK 835

Query: 1522 SIVVPLPFSSQELSI--EDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGL 1579
              VV        ++    + G   V+ +  G+I+ W   T +      F     SY   +
Sbjct: 836  HRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKRTTV------FIKLAPSYKGTV 889

Query: 1580 CGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPV--------RN 1628
            CG+C   +   ++D   ++  ++++  D G    SW+   +       P         R+
Sbjct: 890  CGLCGNFDHRSNNDFTTRDHMVVSSELDFG---NSWKEAPTCPDVSTNPEPCSLNPHRRS 946

Query: 1629 CTEHDCSQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINYTYFWNYEC--DALSAYVAL 1683
              E  CS    +L   +F  CH KV P+ F   C     +     + EC   A+++Y   
Sbjct: 947  WAEKQCS----ILKSSVFSICHSKVDPKPFYEACVHDSCSCDTGGDCECFCSAVASYAQE 1002

Query: 1684 CNKFDICIQWRTPDYCSLSCPEGKEYQPC---VRPCEAR---TCLNQWFYGHTSCLNLRE 1737
            C K   C+ WRTPD C + C        C     PC  R   TC           ++  E
Sbjct: 1003 CTKEGACVFWRTPDLCPIFCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLE 1062

Query: 1738 DCV--CKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795
             C   C     ++     +C+   +C C   +        +      E T   C+     
Sbjct: 1063 GCYPRCPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASV----PTEETCKSCV----- 1113

Query: 1796 IPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTL 1838
                  C      VC  E   ++        C  E+CG + T+
Sbjct: 1114 ------CTNSSQVVCRPEEGKILNQTQDGAFCYWEICGPNGTV 1150



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 27/71 (38%), Positives = 34/71 (47%), Gaps = 4/71 (5%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKF-LPPVEGCLPYCPKNM-ILDEVTLKCVYPRDCIP 1334
            CEW YEPC    F+TC     +     +  +EGC P CPK+  I +E   KCV    C  
Sbjct: 1031 CEWHYEPCGNRSFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCVTADKCGC 1090

Query: 1335 VIPTEPTLMPP 1345
             +  E T  PP
Sbjct: 1091 YV--EDTHYPP 1099



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 59/276 (21%), Positives = 105/276 (38%), Gaps = 33/276 (11%)

Query: 1509 IIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGF 1568
            ++V +    V ++ + V LP  +   S+    S +++ + A  +     L  ++ +    
Sbjct: 358  VVVFKSDGSVLLNELQVNLPHVTASFSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTL 417

Query: 1569 RFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGL-FIESWEIEKSFE-------- 1619
                    +GLCG  N    DD +  +G +    E  G  F  +W+ + S          
Sbjct: 418  DQASQGQVQGLCGNFNGLEGDDFKTASGLV----EATGAGFANTWKAQSSCHDKLDWLDD 473

Query: 1620 -VTMRRPVRNCTEHDCSQCIDLLNR--RIFIPCHDKVSPEDFCEKMWINYTYFWNYE--- 1673
              ++     N  EH CS    LL +    F  CH  V P ++ ++   +     N E   
Sbjct: 474  PCSLNIESANYAEHWCS----LLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCL 529

Query: 1674 CDALSAYVALCNKFDICIQWRTPDYCSL---SCPEGKEYQPCVRPCEARTCLNQWFYGHT 1730
            C ALS+Y   C    + +       C+    SCP  + +   +  C+ +TC        +
Sbjct: 530  CAALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQVFLYNLTTCQ-QTC-RSLSEADS 587

Query: 1731 SCLN---LREDCVCKVGTILHRPHSAQCIPEKECAC 1763
             CL      + C C   T L      +C+P  +C+C
Sbjct: 588  HCLEGFAPVDGCGCPDHTFL--DEKGRCVPLAKCSC 621



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 3/70 (4%)

Query: 1768 DQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCC 1827
            D PR   E W   + +C +  C  N ++  ++ +C+  P P C    + V  + D   CC
Sbjct: 1876 DPPRQENETW--WLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQPVR-VEDPDGCC 1932

Query: 1828 SKEVCGCDTT 1837
                C C  T
Sbjct: 1933 WHWECDCYCT 1942



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 16/145 (11%)

Query: 1520 VDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGI-IDIHFGFRFNLSSYTEG 1578
            ++  VV  P  S  L IE S +   + + AGL + W+    + +++   FR    ++T G
Sbjct: 112  LNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLTLMWNREDALMLELDTKFR----NHTCG 167

Query: 1579 LCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVR-----NCTEHD 1633
            LCG  N        + +G + + +E    F    +I +  +V    P       +C+EH 
Sbjct: 168  LCGDYNGLQSYSEFLSDGVLFSPLE----FGNMQKINQP-DVVCEDPEEEVAPASCSEHR 222

Query: 1634 CSQCIDLLNRRIFIPCHDKVSPEDF 1658
             ++C  LL    F  C D V  E +
Sbjct: 223  -AECERLLTAEAFADCQDLVPLEPY 246



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 25/101 (24%), Positives = 40/101 (39%), Gaps = 13/101 (12%)

Query: 1909 TKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNLC---------PMPLLNCAEDMNLVK 1959
            TKP P C D +    + N T + C  +   C+ N           P P+  C+  +  V+
Sbjct: 1867 TKP-PECPDFDPPRQE-NETWWLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQPVR 1924

Query: 1960 ENVSGQCCPTWHCECNCENLVMPTCEVGEFTAIDHNFQSDC 2000
                  CC  W C+C C     P      F  + +++Q +C
Sbjct: 1925 VEDPDGCCWHWECDCYCTGWGDP--HYVTFDGLYYSYQGNC 1963



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 21/78 (26%), Positives = 32/78 (41%), Gaps = 16/78 (20%)

Query: 1800 PDCDEEPTPVCEREAEVVMGIIDKWTC-CSKEVCGCDTTL------CETS-IPTCTNSQK 1851
            P+C +   P  E E          W C C    C  + T+      CE   +PTC+N  +
Sbjct: 1870 PECPDFDPPRQENETW--------WLCDCFMATCKYNNTVEIVKVECEPPPMPTCSNGLQ 1921

Query: 1852 LIVGHSPLSCCPQYKCEC 1869
             +    P  CC  ++C+C
Sbjct: 1922 PVRVEDPDGCCWHWECDC 1939


>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
          Length = 2812

 Score =  324 bits (830), Expect = 7e-88
 Identities = 298/1197 (24%), Positives = 482/1197 (40%), Gaps = 185/1197 (15%)

Query: 15   FFSPSGSCPYECLNGAFCSKTGTCDCQIFQA-LGTRCQIIPNMGNGRDGI--------CK 65
            +FSP+      C     C      +CQI Q    T CQ+     NG+ G         C 
Sbjct: 1108 WFSPN------CTEHCRCWPGSRVECQISQCGTHTVCQL----KNGQYGCHPYAGTATCL 1157

Query: 66   TWGQYHFETFDGIYYYFPGNCSYIFAKDCGD-LEPRYTVWVHNSPKCLGSVYSCYRSISL 124
             +G  H+ TFDG ++ F G C+YI A+ CG+  +P + V   N  +    V SC   + +
Sbjct: 1158 VYGDPHYVTFDGRHFGFMGKCTYILAQPCGNSTDPFFRVTAKNEEQGQEGV-SCLSKVYV 1216

Query: 125  FFSNQEEIRIYGHEIKKNGISLTLPQTIGQ-IFIEKLADYILVKTTFGFSLAWDGISGIY 183
                     + G      G  +TLP    + +F+     ++ ++T FG  + WDG   +Y
Sbjct: 1217 TLPESTVTLLKGRRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVRWDGDQQLY 1276

Query: 184  LKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSD 243
            + +S  + GK CGLCGNY+    +D + L      D     NSW     +D +C      
Sbjct: 1277 VTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQVV 1336

Query: 244  FPNPCSSGMPAFEAIFFKCQILLQF--PFLSCHEYIDPYLYIASCVNDLCKTDD-DETYC 300
                C S + +  +    C  L+    PF +C  ++    +  SC+ D+C         C
Sbjct: 1337 NSPSCDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLC 1396

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360
               +     C  AG+ ++ WR+    C   C  +  +  C   CP TC      +  +  
Sbjct: 1397 THMSTMTTTCQDAGHAVKPWREPH-FCPMACPPNSKYSLCAKPCPDTCHSGFSGMFCSDR 1455

Query: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFH--GLAYSVGSK-IEQECTE-CVCVGG----- 411
            C++ C C  G V+    CI    C C  H  G  + VG +  +  C E CVC        
Sbjct: 1456 CVEACECNPGFVLSGLECIPRSQCGC-LHPAGSYFKVGERWYKPGCKELCVCESNNRIRC 1514

Query: 412  -VWNCTEQD----------CPVQ----CSVVGDSHFTTFDGRHYSFIGMCQYILVK---G 453
              W C  Q+          C  Q    C+  GD H+ TFDG  + F+G C Y+L +    
Sbjct: 1515 QPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPCWS 1574

Query: 454  TGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG----FN 509
              +D + +    A  E   G++ +  I  +    F+  ++L RG +++ + ++     + 
Sbjct: 1575 RSQDSYFVV--SATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALPVWL 1632

Query: 510  LNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIY-IQLTSAWKRRTLGLCGTFNGNIRD 568
              G V I+ LSS  +LL T FGL++ +  DG  +  + + S++  +  GLCG +N N  D
Sbjct: 1633 AQGRVTIR-LSSNLVLLYTNFGLQVRY--DGSHLVEVTVPSSYGGQLCGLCGNYNNNSLD 1689

Query: 569  DFLSPSGMIEGTPQLHANAWRVSST----CFAPVHVPVVDPCNINQQNIGYAAHCDVI-- 622
            D L P   + G       AW++  +    CF     P    C  N     +  +C ++  
Sbjct: 1690 DNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKP--SSCQENSMADAWNKNCAILIN 1747

Query: 623  HQELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDFRTQIS 680
             Q  F+ CH  + P   +  C H  C  K  ++ LC +L  YA LC Q G    +R + +
Sbjct: 1748 PQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQAPAWRNR-T 1806

Query: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSD--DCAEGCNCPEGKFYEDTLNFCVPI 738
            FC + C  G  Y  CSS C  +C S+++P  C     CAE C C +G     T   CVP+
Sbjct: 1807 FCPMRCPPGSSYSPCSSPCPDTCSSINNPRDCPKALPCAESCECQKGHILSGTS--CVPL 1864

Query: 739  FHCRCHYRGSVYQP-GELIPTPSG---LCQCSNGTVKCDELATPSAVHICPEGKEYFDCR 794
              C C      Y P GE   T +    LC CS                            
Sbjct: 1865 GQCGCTDPAGSYHPVGERWYTENTCTRLCTCS---------------------------- 1896

Query: 795  FPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCT 854
                      V+   TC       TC P+  C +           G+  C       VC 
Sbjct: 1897 ----------VHNNITC----FQSTCKPNQICWA---------LDGLLRCRASGV-GVCQ 1932

Query: 855  IYGDRHYYSFDGLEYDYISDCQVFLIKSADDS----DISVIAQNKK-------------- 896
            + G+ HY SFDG  +     C + L+K    +       + A+++K              
Sbjct: 1933 LPGESHYVSFDGSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVY 1992

Query: 897  --CFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPE 954
               +D  +   K   + +   ++ L   P   +  G  +++ S Y +      + V F  
Sbjct: 1993 IDIYDAQVTLQKGHRVLINSKQVTL---PAISQIPGVSVKSSSIYSIVNIKIGVQVKF-- 2047

Query: 955  KDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW-- 1012
                   D    + I++   +  K+ G+CGNF+    +++   ++    +   F +SW  
Sbjct: 2048 -------DGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKD 2100

Query: 1013 --ALGQCES--PDETIKPCEAHQN--------KFPYAKKEC-SILYSDIFASCRNVIDVT 1059
                  C+S   DE   P E  +N            A+++C + L + ++A C + ID+T
Sbjct: 2101 KDIDPSCQSLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLT 2160

Query: 1060 SFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDCEYYN 1115
             F  +C      C  GG  + LC ++ A+   C  +G+    WR+S+ C L+C  Y+
Sbjct: 2161 PFLVDCANTL--CEFGGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYS 2215



 Score =  259 bits (663), Expect = 2e-68
 Identities = 246/1023 (24%), Positives = 404/1023 (39%), Gaps = 141/1023 (13%)

Query: 64   CKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVY--SCYRS 121
            C   G  H+ TFDG  ++F G C+Y+  + C          V  + +  G +   S  ++
Sbjct: 1542 CTASGDPHYLTFDGALHHFMGTCTYVLTRPCWSRSQDSYFVVSATNENRGGILEVSYIKA 1601

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGI 179
            + +   +     + G ++  NG  + LP  +  G++ I   ++ +L+ T FG  + +DG 
Sbjct: 1602 VHVTVFDLSISLLRGCKVMLNGHRVALPVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGS 1661

Query: 180  SGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVL 239
              + + +   + G+ CGLCGNYN+   DD +        D      +W +    +  C L
Sbjct: 1662 HLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFL 1721

Query: 240  TPSDFPNPCSSGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCVNDLCKTDDDE 297
                 P+ C     A +A    C IL+  Q PF  CH+ + P    ASCV+  C T  D 
Sbjct: 1722 VGGK-PSSCQENSMA-DAWNKNCAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDT 1779

Query: 298  T-YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF---EKQ 353
            T  CR+   YA  C+ AG     WR+    C  +C     +  C S CP TC+     + 
Sbjct: 1780 TALCRSLQAYASLCAQAGQA-PAWRNR-TFCPMRCPPGSSYSPCSSPCPDTCSSINNPRD 1837

Query: 354  CLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYS-VGSK--IEQECTE-CVC- 408
            C  + L C + C C  G ++   +C+ L  C C     +Y  VG +   E  CT  C C 
Sbjct: 1838 CPKA-LPCAESCECQKGHILSGTSCVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCS 1896

Query: 409  VGGVWNCTEQDC-PVQ------------------CSVVGDSHFTTFDGRHYSFIGMCQYI 449
            V     C +  C P Q                  C + G+SH+ +FDG ++S    C  +
Sbjct: 1897 VHNNITCFQSTCKPNQICWALDGLLRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLV 1956

Query: 450  LVK----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPN 505
            LVK          F I+ +    E       L  + +   D ++ QVTL +G ++L +  
Sbjct: 1957 LVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYI---DIYDAQVTLQKGHRVLINSK 2013

Query: 506  QGFNLNGIVEIQTLS----SLFILLKTTFGLKILFAIDGERIY-IQLTSAWKRRTLGLCG 560
            Q   L  I +I  +S    S++ ++    G+++ F  DG  +  I++ + +  +  G+CG
Sbjct: 2014 Q-VTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKF--DGNHLLEIEIPTTYYGKVCGMCG 2070

Query: 561  TFNGNIRDDFLSPSGMIEGTPQLHANAWR---VSSTCFAPVHVPVVDPCNINQQNIGYAA 617
             FN    D+ + PS  +  +     N+W+   +  +C + +      P    +   G   
Sbjct: 2071 NFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQSLLVDEQQIPAEQQENPSGNCR 2130

Query: 618  HCDV----------IHQELFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYL 665
              D+          +   ++A C   I    +   C +  C+ G     LC AL  +   
Sbjct: 2131 AADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCANTLCEFGGLYQALCQALQAFGAT 2190

Query: 666  CGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLS---SPEQCSDDCAEGCNC 722
            C   G+        SFC + C     Y +C   C  SC  L       +    CAEGC C
Sbjct: 2191 CQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSCSPSCWDLDGRCEGAKVPSACAEGCIC 2250

Query: 723  PEGKFYEDTLNFCVPIFHCRCH--YRGSVYQPGELIPTP-SGLCQCSNGTVKCDELATPS 779
              G  Y  + + CVP   C C   + GS+      + +  +  C C+ G ++C +   PS
Sbjct: 2251 QPG--YVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSGCTEKCVCTGGAIQCGDFRCPS 2308

Query: 780  AVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRR 839
              H                        C+ T  N         +S C+S           
Sbjct: 2309 GSH------------------------CQLTSDN--------SNSNCVS----------- 2325

Query: 840  GMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSAD-----DSDISVIAQN 894
                         C++YGD  Y +FDG  Y         LIK+ D        + V  +N
Sbjct: 2326 --------DKSEQCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRN 2377

Query: 895  KKCFDNDIVCSKSVLISVGDTEIYLND----TPYKQKQSGFFLENKS-TYQLWKAGYYIV 949
            K       +  + V+ +V   ++ L          QK +  +  N+     LW    Y+V
Sbjct: 2378 KMDPPRSSIFLQEVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLV 2437

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
              F   ++ + +  +    I +   ++  +SGLCGN+DK   NDM   +    +N   FG
Sbjct: 2438 TDF---ELVVSFGGRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFG 2494

Query: 1010 DSW 1012
            +SW
Sbjct: 2495 NSW 2497



 Score =  209 bits (532), Expect = 2e-53
 Identities = 208/848 (24%), Positives = 327/848 (38%), Gaps = 140/848 (16%)

Query: 328  TDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCG 387
            T++C  +  +  C   CP +C   +   G    C +GC C  G +  +  CI   +C C 
Sbjct: 1041 TERCPPNARYESC--ACPASCKSPRPSCGPL--CREGCVCNPGFLFSDNHCIQASSCNCF 1096

Query: 388  FHGLAYSVGSK-IEQECTE----------------------CVCVGGVWNCTEQDCPVQC 424
            ++   Y  G++     CTE                      C    G + C        C
Sbjct: 1097 YNNDYYEPGAEWFSPNCTEHCRCWPGSRVECQISQCGTHTVCQLKNGQYGCHPYAGTATC 1156

Query: 425  SVVGDSHFTTFDGRHYSFIGMCQYILVK--GTGKDKFTITLQKAPCEQNLGLVCLQSITL 482
             V GD H+ TFDGRH+ F+G C YIL +  G   D F     K   +   G+ CL  + +
Sbjct: 1157 LVYGDPHYVTFDGRHFGFMGKCTYILAQPCGNSTDPFFRVTAKNEEQGQEGVSCLSKVYV 1216

Query: 483  ILEDDFNKQVTL--GR----GGQILT---SPNQGFNLNGIVEIQTLSSLFILLKTTFGLK 533
             L +     VTL  GR    GGQ +T    P++G  L         S  F+ L+T FGL+
Sbjct: 1217 TLPE---STVTLLKGRRTLVGGQQVTLPAIPSKGVFLGA-------SGRFVELQTEFGLR 1266

Query: 534  ILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRV--- 590
            + +  D +++Y+ ++S +  +  GLCG ++GN  +D L   G   G  +   N+W+    
Sbjct: 1267 VRWDGD-QQLYVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQD 1325

Query: 591  -SSTC--FAPVHVPVVD-PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHD 646
                C  +  V+ P  D     +    G+       H   F  C +++    ++  C  D
Sbjct: 1326 EDQECQKYQVVNSPSCDSSLQSSMSGPGFCGRLVDTHGP-FETCLLHVKAASFFDSCMLD 1384

Query: 647  AC--KCGSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCI 704
             C  +     LC  ++     C   G  +    +  FC + C     Y  C+  C  +C 
Sbjct: 1385 MCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCH 1444

Query: 705  SLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRC-HYRGSVYQPGE--LIPTPSG 761
            S  S   CSD C E C C  G F    L  C+P   C C H  GS ++ GE    P    
Sbjct: 1445 SGFSGMFCSDRCVEACECNPG-FVLSGLE-CIPRSQCGCLHPAGSYFKVGERWYKPGCKE 1502

Query: 762  LCQC-SNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTC 820
            LC C SN  ++C       A   C +    + C        A G              TC
Sbjct: 1503 LCVCESNNRIRCQPWRC-RAQEFCGQQDGIYGCH-------AQGA------------ATC 1542

Query: 821  TPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLI 880
            T S                                 GD HY +FDG  + ++  C   L 
Sbjct: 1543 TAS---------------------------------GDPHYLTFDGALHHFMGTCTYVLT 1569

Query: 881  K----SADDSDISVIAQNK-KCFDNDIVCSKSVLISVGDTEIYLND------TPYKQKQS 929
            +     + DS   V A N+ +    ++   K+V ++V D  I L          ++    
Sbjct: 1570 RPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALP 1629

Query: 930  GFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKC 989
             +  + + T +L      +V+ +    + + +D    + + V   +  +L GLCGN++  
Sbjct: 1630 VWLAQGRVTIRL---SSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNN 1686

Query: 990  TSNDMTTSNNLEVRNARVFGDSWALGQCESPDETI---KPCEAHQNKFPYA-KKECSILY 1045
            + +D    +     ++   G +W L +   P   +   KP    +N    A  K C+IL 
Sbjct: 1687 SLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKPSSCQENSMADAWNKNCAILI 1746

Query: 1046 S--DIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRS 1103
            +    F+ C  V+   S   +C    C     GD   LC S+ AYA  C Q G +  WR+
Sbjct: 1747 NPQGPFSQCHQVVPPQSSFASCVHGQCGTK--GDTTALCRSLQAYASLCAQAGQAPAWRN 1804

Query: 1104 STVCSLDC 1111
             T C + C
Sbjct: 1805 RTFCPMRC 1812



 Score =  175 bits (444), Expect = 4e-43
 Identities = 188/844 (22%), Positives = 309/844 (36%), Gaps = 125/844 (14%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCY 119
            G+C+  G+ H+ +FDG  +  P  C+ +  K C      P + +   +  +  G+     
Sbjct: 1929 GVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRL 1988

Query: 120  RSISLFFSNQEEIRIYGHEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWD 177
              + +   + +     GH +  N   +TLP    I  + ++  + Y +V    G  + +D
Sbjct: 1989 HEVYIDIYDAQVTLQKGHRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFD 2048

Query: 178  GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQ--TPDDT 235
            G   + +++   + GK CG+CGN+ND + D+ ++  ++     + F NSW  +   P   
Sbjct: 2049 GNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQ 2108

Query: 236  KCVLTPSDFP-----NPCSSGMPA-FEAIFFKCQILLQFP-FLSCHEYIDPYLYIASCVN 288
              ++     P     NP  +   A       KC+  L+ P +  C   ID   ++  C N
Sbjct: 2109 SLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCAN 2168

Query: 289  DLCKTDD-DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPT 347
             LC+     +  C+A   +   C   G     WR+    C  +C     + +C+  C P+
Sbjct: 2169 TLCEFGGLYQALCQALQAFGATCQSQGLKPPLWRNS-SFCPLECPAYSSYTNCLPSCSPS 2227

Query: 348  C-TFEKQCLGSNL--HCLDGCYCPDGLVMDNGTCISLENCPC-GFHGLAYSVG-SKIEQE 402
            C   + +C G+ +   C +GC C  G V+    C+    C C   HG +  +G S +   
Sbjct: 2228 CWDLDGRCEGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSG 2287

Query: 403  CTE-CVCVGGVWNCTEQDCP---------------------VQCSVVGDSHFTTFDGRHY 440
            CTE CVC GG   C +  CP                      QCSV GD  + TFDG  Y
Sbjct: 2288 CTEKCVCTGGAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSEQCSVYGDPRYLTFDGFSY 2347

Query: 441  SFIGMCQYILVKGT-----GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLG 495
               G   Y+L+K       G +   +  +         +   + IT +    +  +V L 
Sbjct: 2348 RLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQEVITTV----YGYKVQLQ 2403

Query: 496  RGGQILTS---------PNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQ 546
             G +++ +         PN+   +       TL    + L T F L + F    +   I 
Sbjct: 2404 AGLELVVNNQKMAVPYRPNEHLRV-------TLWGQRLYLVTDFELVVSFG-GRKNAVIS 2455

Query: 547  LTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRV---SSTCFAPVHVPV- 602
            L S ++    GLCG ++ N ++D + PSG +        N+W V    +    P  +P  
Sbjct: 2456 LPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTEDALLRFPRAIPAE 2515

Query: 603  ---------------VDPCNINQQNIGYAAHCDVI--HQELFAPCHIYISPGLYYQLCRH 645
                           V  C+  Q        C V+   Q  FA CH  ++P  + + C  
Sbjct: 2516 EEGQGAELGLRTGLQVSECSPEQLASNSTQACRVLADPQGPFAACHQTVAPEPFQEHCVL 2575

Query: 646  DACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQISF-CAVVCQKGMLYHHCSSFCLHSCI 704
            D C                         D R Q    C V+   G+   +  S    +  
Sbjct: 2576 DLCSAQ----------------------DPREQEELRCQVLSGHGVSSRYHISELYDTLP 2613

Query: 705  SLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCV------PIFHCRCHYRGSVYQPGELIPT 758
            S+     C      G   P           C+      P+  C C   G  YQ G    T
Sbjct: 2614 SI----LCQPGRPRGLRGPLRGRLRQHPRLCLQWHPEPPLADCGCTSNGIYYQLGSSFLT 2669

Query: 759  P--SGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAM 816
               S  C C++  +   E  +  A  +C  G     C FP+          +  C     
Sbjct: 2670 EDCSQRCTCASSRILLCEPFSCRAGEVCTLGNHTQGC-FPESPCLQNPCQNDGQCREQGA 2728

Query: 817  NFTC 820
             FTC
Sbjct: 2729 TFTC 2732



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 98/441 (22%), Positives = 159/441 (36%), Gaps = 58/441 (13%)

Query: 1411 DVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI 1470
            + ++  CG        N    C  +     C +  +   +TFDG +       +YIL + 
Sbjct: 1126 ECQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGFMGKCTYILAQP 1185

Query: 1471 PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLP-F 1529
             G          + N+   G+    C  K+ VT P   + + +  R+  V    V LP  
Sbjct: 1186 CGNSTDPFFRVTAKNEE-QGQEGVSCLSKVYVTLPESTVTLLK-GRRTLVGGQQVTLPAI 1243

Query: 1530 SSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDD 1589
             S+ + +  SG    + T  GL ++W    G   ++       S    GLCG  + + D+
Sbjct: 1244 PSKGVFLGASGRFVELQTEFGLRVRWD---GDQQLYVTVSSTYSGKLCGLCGNYDGNSDN 1300

Query: 1590 DLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRR-PVRNCTEHD------------CSQ 1636
            D    +G+   + E++G    SW+ ++  +   ++  V N    D            C +
Sbjct: 1301 DHLKLDGSPAGDKEELG---NSWQTDQDEDQECQKYQVVNSPSCDSSLQSSMSGPGFCGR 1357

Query: 1637 CIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             +D      F  C   V    F +   ++   F   +   C  +S     C      ++ 
Sbjct: 1358 LVD--THGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKP 1415

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHS 1752
            WR P +C ++CP   +Y  C +PC   TC +  F G        E C C  G +L     
Sbjct: 1416 WREPHFCPMACPPNSKYSLCAKPC-PDTC-HSGFSGMFCSDRCVEACECNPGFVL---SG 1470

Query: 1753 AQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCER 1812
             +CIP  +C C          GE W         YK           P C E    VCE 
Sbjct: 1471 LECIPRSQCGCLHPAGSYFKVGERW---------YK-----------PGCKE--LCVCES 1508

Query: 1813 EAEVVMGIIDKWTCCSKEVCG 1833
               +       W C ++E CG
Sbjct: 1509 NNRI---RCQPWRCRAQEFCG 1526



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 100/427 (23%), Positives = 162/427 (37%), Gaps = 64/427 (14%)

Query: 1427 NSDICCPEWECPCR-------------------CSMLSELSIITFDGNNAALYSMASYIL 1467
            N+ I C  W C  +                   C+   +   +TFDG         +Y+L
Sbjct: 1509 NNRIRCQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVL 1568

Query: 1468 VR-IPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR-KVEVDSIVV 1525
             R        ++    + N+   G +     K ++VT     I + R  +  +    + +
Sbjct: 1569 TRPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVAL 1628

Query: 1526 PLPFSSQELSIEDSGSMYVITTPAGLIIKW--SHLTGIIDIHFGFRFNLSSYTEGLCGIC 1583
            P+  +   ++I  S ++ ++ T  GL +++  SHL  +           SSY   LCG+C
Sbjct: 1629 PVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVP--------SSYGGQLCGLC 1680

Query: 1584 ----NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE----VTMRRPVRNCTEHDCS 1635
                N   DD+LR        +M+ +G    +W++ +S E    +   +P  +C E+  +
Sbjct: 1681 GNYNNNSLDDNLRPDRKLAGDSMQ-LGA---AWKLPESSEPGCFLVGGKP-SSCQENSMA 1735

Query: 1636 Q-----CIDLLNRR-IFIPCHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVALCNK 1686
                  C  L+N +  F  CH  V P+     C              C +L AY +LC +
Sbjct: 1736 DAWNKNCAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQ 1795

Query: 1687 FDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC---LNLREDCVCKV 1743
                  WR   +C + CP G  Y PC  PC   TC +        C   L   E C C+ 
Sbjct: 1796 AGQAPAWRNRTFCPMRCPPGSSYSPCSSPC-PDTCSS--INNPRDCPKALPCAESCECQK 1852

Query: 1744 GTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCD 1803
            G IL       C+P  +C CTD        GE W        L  C  + +I   +  C 
Sbjct: 1853 GHIL---SGTSCVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCSVHNNITCFQSTC- 1908

Query: 1804 EEPTPVC 1810
             +P  +C
Sbjct: 1909 -KPNQIC 1914



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 114/557 (20%), Positives = 203/557 (36%), Gaps = 116/557 (20%)

Query: 1281 YEPCATPCFKTCSD-------PEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCI 1333
            Y PC++PC  TCS        P+AL C      E C   C K  IL   +        C+
Sbjct: 1818 YSPCSSPCPDTCSSINNPRDCPKALPC-----AESC--ECQKGHILSGTS--------CV 1862

Query: 1334 PVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYI 1393
            P+     T   PA    P+   W   T +  T     +    + C      P   C    
Sbjct: 1863 PLGQCGCT--DPAGSYHPVGERW--YTENTCTRLCTCSVHNNITCFQSTCKPNQIC---- 1914

Query: 1394 CLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFD 1453
                      W+L+      +  C   G  V                C +  E   ++FD
Sbjct: 1915 ----------WALD-----GLLRCRASGVGV----------------CQLPGESHYVSFD 1943

Query: 1454 GNNAALYSMASYILVRIPGEIIVAHIEKCSM-NQAPSGRISGLCFKKLNVTTPIHKIIVN 1512
            G+N ++    + +LV++    +     K S  ++   G        ++ +     ++ + 
Sbjct: 1944 GSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYIDIYDAQVTLQ 2003

Query: 1513 RLARKVEVDSIVVPLPFSSQ--ELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRF 1570
            +   +V ++S  V LP  SQ   +S++ S    ++    G+ +K+     +++I      
Sbjct: 2004 K-GHRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFDG-NHLLEIEIP--- 2058

Query: 1571 NLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESW---EIEKSFEVTM-- 1622
              ++Y   +CG+C   N++ +D+L M +  +  +  +   F+ SW   +I+ S +  +  
Sbjct: 2059 --TTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSE---FVNSWKDKDIDPSCQSLLVD 2113

Query: 1623 ---------RRPVRNCTEHDC----SQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINY 1666
                       P  NC   D      +C   L   ++  C  ++    F   C      +
Sbjct: 2114 EQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCANTLCEF 2173

Query: 1667 TYFWNYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTC--LN 1723
               +   C AL A+ A C    +    WR   +C L CP    Y  C+  C + +C  L+
Sbjct: 2174 GGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSC-SPSCWDLD 2232

Query: 1724 QWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIW------ 1777
                G        E C+C+ G +L      +C+P  +C C D+       G+ W      
Sbjct: 2233 GRCEGAKVPSACAEGCICQPGYVLSED---KCVPRSQCGCKDAHGGSIPLGKSWVSSGCT 2289

Query: 1778 -----NGGIDECTLYKC 1789
                  GG  +C  ++C
Sbjct: 2290 EKCVCTGGAIQCGDFRC 2306



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 93/432 (21%), Positives = 164/432 (37%), Gaps = 80/432 (18%)

Query: 19   SGSCPYECLNGAFCSKTGTCDCQIFQA-LGTRCQIIPNMGNG-----RDGICKTWGQYHF 72
            S  C  +C+    C+  G   C  F+   G+ CQ+  +  N      +   C  +G   +
Sbjct: 2285 SSGCTEKCV----CTG-GAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSEQCSVYGDPRY 2339

Query: 73   ETFDGIYYYFPGNCSYIFAKDCGDL----EPRYTVWVHNSPKCLGSVYSCYRSISLFFSN 128
             TFDG  Y   G  +Y+  K    L    EP      +       S++     I+  +  
Sbjct: 2340 LTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIF-LQEVITTVYGY 2398

Query: 129  QEEIRIYGHEIKKNGISLTLPQTIGQ-IFIEKLADYILVKTTFGFSLAWDGISGIYLKLS 187
            + +++  G E+  N   + +P    + + +      + + T F   +++ G     + L 
Sbjct: 2399 KVQLQA-GLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGRKNAVISLP 2457

Query: 188  EDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFP-- 245
              ++G   GLCGNY+  + +D ++     T+++  F NSW V+T D    +  P   P  
Sbjct: 2458 SMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTED--ALLRFPRAIPAE 2515

Query: 246  ----------------NPCSSGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCV 287
                            + CS    A  +    C++L   Q PF +CH+ + P  +   CV
Sbjct: 2516 EEGQGAELGLRTGLQVSECSPEQLASNST-QACRVLADPQGPFAACHQTVAPEPFQEHCV 2574

Query: 288  NDLCKTDD----DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISC 343
             DLC   D    +E  C+  + +  +   + Y I +  D  P+              I C
Sbjct: 2575 LDLCSAQDPREQEELRCQVLSGHGVS---SRYHISELYDTLPS--------------ILC 2617

Query: 344  CPPTCTFEKQCLGSNLH-----CLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSK 398
             P      +  L   L      CL     P            L +C C  +G+ Y +GS 
Sbjct: 2618 QPGRPRGLRGPLRGRLRQHPRLCLQWHPEP-----------PLADCGCTSNGIYYQLGSS 2666

Query: 399  -IEQECTE-CVC 408
             + ++C++ C C
Sbjct: 2667 FLTEDCSQRCTC 2678



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 38/191 (19%), Positives = 81/191 (42%), Gaps = 16/191 (8%)

Query: 1440 RCSMLSELSIITFDGNNAALYSMASYILVR----IPGEIIVAHIEKCSMNQAPSGRISGL 1495
            +CS+  +   +TFDG +  L    +Y+L++    +P  +    +E  +    P   I   
Sbjct: 2330 QCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSI--- 2386

Query: 1496 CFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-LSIEDSGSMYVITTPAGLIIK 1554
             F +  +TT     +  +   ++ V++  + +P+   E L +   G    + T   L++ 
Sbjct: 2387 -FLQEVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVS 2445

Query: 1555 WSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEI 1614
            +    G  +              GLCG  +++  +D+ + +G +  N+   G    SWE+
Sbjct: 2446 FG---GRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFG---NSWEV 2499

Query: 1615 EKSFEVTMRRP 1625
             K+ +  +R P
Sbjct: 2500 -KTEDALLRFP 2509



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 26/99 (26%), Positives = 33/99 (33%), Gaps = 22/99 (22%)

Query: 1703 CPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNL-REDCVCKVGTILHRPHSAQCIPEKEC 1761
            CP    Y+ C  P   ++          SC  L RE CVC  G +    H   CI    C
Sbjct: 1044 CPPNARYESCACPASCKS-------PRPSCGPLCREGCVCNPGFLFSDNH---CIQASSC 1093

Query: 1762 ACTDSEDQPRTAGE-----------IWNGGIDECTLYKC 1789
             C  + D      E            W G   EC + +C
Sbjct: 1094 NCFYNNDYYEPGAEWFSPNCTEHCRCWPGSRVECQISQC 1132


>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
          Length = 2721

 Score =  324 bits (830), Expect = 7e-88
 Identities = 298/1197 (24%), Positives = 482/1197 (40%), Gaps = 185/1197 (15%)

Query: 15   FFSPSGSCPYECLNGAFCSKTGTCDCQIFQA-LGTRCQIIPNMGNGRDGI--------CK 65
            +FSP+      C     C      +CQI Q    T CQ+     NG+ G         C 
Sbjct: 1108 WFSPN------CTEHCRCWPGSRVECQISQCGTHTVCQL----KNGQYGCHPYAGTATCL 1157

Query: 66   TWGQYHFETFDGIYYYFPGNCSYIFAKDCGD-LEPRYTVWVHNSPKCLGSVYSCYRSISL 124
             +G  H+ TFDG ++ F G C+YI A+ CG+  +P + V   N  +    V SC   + +
Sbjct: 1158 VYGDPHYVTFDGRHFGFMGKCTYILAQPCGNSTDPFFRVTAKNEEQGQEGV-SCLSKVYV 1216

Query: 125  FFSNQEEIRIYGHEIKKNGISLTLPQTIGQ-IFIEKLADYILVKTTFGFSLAWDGISGIY 183
                     + G      G  +TLP    + +F+     ++ ++T FG  + WDG   +Y
Sbjct: 1217 TLPESTVTLLKGRRTLVGGQQVTLPAIPSKGVFLGASGRFVELQTEFGLRVRWDGDQQLY 1276

Query: 184  LKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSD 243
            + +S  + GK CGLCGNY+    +D + L      D     NSW     +D +C      
Sbjct: 1277 VTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQDEDQECQKYQVV 1336

Query: 244  FPNPCSSGMPAFEAIFFKCQILLQF--PFLSCHEYIDPYLYIASCVNDLCKTDD-DETYC 300
                C S + +  +    C  L+    PF +C  ++    +  SC+ D+C         C
Sbjct: 1337 NSPSCDSSLQSSMSGPGFCGRLVDTHGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLC 1396

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLH 360
               +     C  AG+ ++ WR+    C   C  +  +  C   CP TC      +  +  
Sbjct: 1397 THMSTMTTTCQDAGHAVKPWREPH-FCPMACPPNSKYSLCAKPCPDTCHSGFSGMFCSDR 1455

Query: 361  CLDGCYCPDGLVMDNGTCISLENCPCGFH--GLAYSVGSK-IEQECTE-CVCVGG----- 411
            C++ C C  G V+    CI    C C  H  G  + VG +  +  C E CVC        
Sbjct: 1456 CVEACECNPGFVLSGLECIPRSQCGC-LHPAGSYFKVGERWYKPGCKELCVCESNNRIRC 1514

Query: 412  -VWNCTEQD----------CPVQ----CSVVGDSHFTTFDGRHYSFIGMCQYILVK---G 453
              W C  Q+          C  Q    C+  GD H+ TFDG  + F+G C Y+L +    
Sbjct: 1515 QPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPCWS 1574

Query: 454  TGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG----FN 509
              +D + +    A  E   G++ +  I  +    F+  ++L RG +++ + ++     + 
Sbjct: 1575 RSQDSYFVV--SATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALPVWL 1632

Query: 510  LNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIY-IQLTSAWKRRTLGLCGTFNGNIRD 568
              G V I+ LSS  +LL T FGL++ +  DG  +  + + S++  +  GLCG +N N  D
Sbjct: 1633 AQGRVTIR-LSSNLVLLYTNFGLQVRY--DGSHLVEVTVPSSYGGQLCGLCGNYNNNSLD 1689

Query: 569  DFLSPSGMIEGTPQLHANAWRVSST----CFAPVHVPVVDPCNINQQNIGYAAHCDVI-- 622
            D L P   + G       AW++  +    CF     P    C  N     +  +C ++  
Sbjct: 1690 DNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKP--SSCQENSMADAWNKNCAILIN 1747

Query: 623  HQELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDFRTQIS 680
             Q  F+ CH  + P   +  C H  C  K  ++ LC +L  YA LC Q G    +R + +
Sbjct: 1748 PQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQAGQAPAWRNR-T 1806

Query: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSD--DCAEGCNCPEGKFYEDTLNFCVPI 738
            FC + C  G  Y  CSS C  +C S+++P  C     CAE C C +G     T   CVP+
Sbjct: 1807 FCPMRCPPGSSYSPCSSPCPDTCSSINNPRDCPKALPCAESCECQKGHILSGTS--CVPL 1864

Query: 739  FHCRCHYRGSVYQP-GELIPTPSG---LCQCSNGTVKCDELATPSAVHICPEGKEYFDCR 794
              C C      Y P GE   T +    LC CS                            
Sbjct: 1865 GQCGCTDPAGSYHPVGERWYTENTCTRLCTCS---------------------------- 1896

Query: 795  FPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCT 854
                      V+   TC       TC P+  C +           G+  C       VC 
Sbjct: 1897 ----------VHNNITC----FQSTCKPNQICWA---------LDGLLRCRASGV-GVCQ 1932

Query: 855  IYGDRHYYSFDGLEYDYISDCQVFLIKSADDS----DISVIAQNKK-------------- 896
            + G+ HY SFDG  +     C + L+K    +       + A+++K              
Sbjct: 1933 LPGESHYVSFDGSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVY 1992

Query: 897  --CFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPE 954
               +D  +   K   + +   ++ L   P   +  G  +++ S Y +      + V F  
Sbjct: 1993 IDIYDAQVTLQKGHRVLINSKQVTL---PAISQIPGVSVKSSSIYSIVNIKIGVQVKF-- 2047

Query: 955  KDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW-- 1012
                   D    + I++   +  K+ G+CGNF+    +++   ++    +   F +SW  
Sbjct: 2048 -------DGNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKD 2100

Query: 1013 --ALGQCES--PDETIKPCEAHQN--------KFPYAKKEC-SILYSDIFASCRNVIDVT 1059
                  C+S   DE   P E  +N            A+++C + L + ++A C + ID+T
Sbjct: 2101 KDIDPSCQSLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLT 2160

Query: 1060 SFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDCEYYN 1115
             F  +C      C  GG  + LC ++ A+   C  +G+    WR+S+ C L+C  Y+
Sbjct: 2161 PFLVDCANTL--CEFGGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYS 2215



 Score =  272 bits (696), Expect = 2e-72
 Identities = 271/1148 (23%), Positives = 448/1148 (39%), Gaps = 168/1148 (14%)

Query: 64   CKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVY--SCYRS 121
            C   G  H+ TFDG  ++F G C+Y+  + C          V  + +  G +   S  ++
Sbjct: 1542 CTASGDPHYLTFDGALHHFMGTCTYVLTRPCWSRSQDSYFVVSATNENRGGILEVSYIKA 1601

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGI 179
            + +   +     + G ++  NG  + LP  +  G++ I   ++ +L+ T FG  + +DG 
Sbjct: 1602 VHVTVFDLSISLLRGCKVMLNGHRVALPVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGS 1661

Query: 180  SGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVL 239
              + + +   + G+ CGLCGNYN+   DD +        D      +W +    +  C L
Sbjct: 1662 HLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFL 1721

Query: 240  TPSDFPNPCSSGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCVNDLCKTDDDE 297
                 P+ C     A +A    C IL+  Q PF  CH+ + P    ASCV+  C T  D 
Sbjct: 1722 VGGK-PSSCQENSMA-DAWNKNCAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDT 1779

Query: 298  T-YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF---EKQ 353
            T  CR+   YA  C+ AG     WR+    C  +C     +  C S CP TC+     + 
Sbjct: 1780 TALCRSLQAYASLCAQAGQA-PAWRNR-TFCPMRCPPGSSYSPCSSPCPDTCSSINNPRD 1837

Query: 354  CLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYS-VGSK--IEQECTE-CVC- 408
            C  + L C + C C  G ++   +C+ L  C C     +Y  VG +   E  CT  C C 
Sbjct: 1838 CPKA-LPCAESCECQKGHILSGTSCVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCS 1896

Query: 409  VGGVWNCTEQDC-PVQ------------------CSVVGDSHFTTFDGRHYSFIGMCQYI 449
            V     C +  C P Q                  C + G+SH+ +FDG ++S    C  +
Sbjct: 1897 VHNNITCFQSTCKPNQICWALDGLLRCRASGVGVCQLPGESHYVSFDGSNHSIPDACTLV 1956

Query: 450  LVK----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPN 505
            LVK          F I+ +    E       L  + +   D ++ QVTL +G ++L +  
Sbjct: 1957 LVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYI---DIYDAQVTLQKGHRVLINSK 2013

Query: 506  QGFNLNGIVEIQTLS----SLFILLKTTFGLKILFAIDGERIY-IQLTSAWKRRTLGLCG 560
            Q   L  I +I  +S    S++ ++    G+++ F  DG  +  I++ + +  +  G+CG
Sbjct: 2014 Q-VTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKF--DGNHLLEIEIPTTYYGKVCGMCG 2070

Query: 561  TFNGNIRDDFLSPSGMIEGTPQLHANAWR---VSSTCFAPVHVPVVDPCNINQQNIGYAA 617
             FN    D+ + PS  +  +     N+W+   +  +C + +      P    +   G   
Sbjct: 2071 NFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQSLLVDEQQIPAEQQENPSGNCR 2130

Query: 618  HCDV----------IHQELFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYL 665
              D+          +   ++A C   I    +   C +  C+ G     LC AL  +   
Sbjct: 2131 AADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCANTLCEFGGLYQALCQALQAFGAT 2190

Query: 666  CGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLS---SPEQCSDDCAEGCNC 722
            C   G+        SFC + C     Y +C   C  SC  L       +    CAEGC C
Sbjct: 2191 CQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSCSPSCWDLDGRCEGAKVPSACAEGCIC 2250

Query: 723  PEGKFYEDTLNFCVPIFHCRCH--YRGSVYQPGELIPTP-SGLCQCSNGTVKCDELATPS 779
              G  Y  + + CVP   C C   + GS+      + +  +  C C+ G ++C +   PS
Sbjct: 2251 QPG--YVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSGCTEKCVCTGGAIQCGDFRCPS 2308

Query: 780  AVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRR 839
              H                        C+ T  N         +S C+S           
Sbjct: 2309 GSH------------------------CQLTSDN--------SNSNCVS----------- 2325

Query: 840  GMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSAD-----DSDISVIAQN 894
                         C++YGD  Y +FDG  Y         LIK+ D        + V  +N
Sbjct: 2326 --------DKSEQCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRN 2377

Query: 895  KKCFDNDIVCSKSVLISVGDTEIYLND----TPYKQKQSGFFLENKS-TYQLWKAGYYIV 949
            K       +  + V+ +V   ++ L          QK +  +  N+     LW    Y+V
Sbjct: 2378 KMDPPRSSIFLQEVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLV 2437

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
              F   ++ + +  +    I +   ++  +SGLCGN+DK   NDM   +    +N   FG
Sbjct: 2438 TDF---ELVVSFGGRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFG 2494

Query: 1010 DSWALGQCES--------PDE--------------TIKPCEAHQNKFPYAKKECSILY-- 1045
            +SW +   ++        P E               +  C   Q     + + C +L   
Sbjct: 2495 NSWEVKTEDALLRFPRAIPAEEEGQGAELGLRTGLQVSECSPEQ-LASNSTQACRVLADP 2553

Query: 1046 SDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECL-CTSIAAYAYKCCQEGISI-HWRS 1103
               FA+C   +    F ++C  D C+     + E L C  ++ YA  C + G ++  WR 
Sbjct: 2554 QGPFAACHQTVAPEPFQEHCVLDLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRD 2613

Query: 1104 STVCSLDC 1111
             T+C   C
Sbjct: 2614 RTLCESPC 2621



 Score =  209 bits (532), Expect = 2e-53
 Identities = 208/848 (24%), Positives = 327/848 (38%), Gaps = 140/848 (16%)

Query: 328  TDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCG 387
            T++C  +  +  C   CP +C   +   G    C +GC C  G +  +  CI   +C C 
Sbjct: 1041 TERCPPNARYESC--ACPASCKSPRPSCGPL--CREGCVCNPGFLFSDNHCIQASSCNCF 1096

Query: 388  FHGLAYSVGSK-IEQECTE----------------------CVCVGGVWNCTEQDCPVQC 424
            ++   Y  G++     CTE                      C    G + C        C
Sbjct: 1097 YNNDYYEPGAEWFSPNCTEHCRCWPGSRVECQISQCGTHTVCQLKNGQYGCHPYAGTATC 1156

Query: 425  SVVGDSHFTTFDGRHYSFIGMCQYILVK--GTGKDKFTITLQKAPCEQNLGLVCLQSITL 482
             V GD H+ TFDGRH+ F+G C YIL +  G   D F     K   +   G+ CL  + +
Sbjct: 1157 LVYGDPHYVTFDGRHFGFMGKCTYILAQPCGNSTDPFFRVTAKNEEQGQEGVSCLSKVYV 1216

Query: 483  ILEDDFNKQVTL--GR----GGQILT---SPNQGFNLNGIVEIQTLSSLFILLKTTFGLK 533
             L +     VTL  GR    GGQ +T    P++G  L         S  F+ L+T FGL+
Sbjct: 1217 TLPE---STVTLLKGRRTLVGGQQVTLPAIPSKGVFLGA-------SGRFVELQTEFGLR 1266

Query: 534  ILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRV--- 590
            + +  D +++Y+ ++S +  +  GLCG ++GN  +D L   G   G  +   N+W+    
Sbjct: 1267 VRWDGD-QQLYVTVSSTYSGKLCGLCGNYDGNSDNDHLKLDGSPAGDKEELGNSWQTDQD 1325

Query: 591  -SSTC--FAPVHVPVVD-PCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHD 646
                C  +  V+ P  D     +    G+       H   F  C +++    ++  C  D
Sbjct: 1326 EDQECQKYQVVNSPSCDSSLQSSMSGPGFCGRLVDTHGP-FETCLLHVKAASFFDSCMLD 1384

Query: 647  AC--KCGSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCI 704
             C  +     LC  ++     C   G  +    +  FC + C     Y  C+  C  +C 
Sbjct: 1385 MCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPHFCPMACPPNSKYSLCAKPCPDTCH 1444

Query: 705  SLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRC-HYRGSVYQPGE--LIPTPSG 761
            S  S   CSD C E C C  G F    L  C+P   C C H  GS ++ GE    P    
Sbjct: 1445 SGFSGMFCSDRCVEACECNPG-FVLSGLE-CIPRSQCGCLHPAGSYFKVGERWYKPGCKE 1502

Query: 762  LCQC-SNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTC 820
            LC C SN  ++C       A   C +    + C        A G              TC
Sbjct: 1503 LCVCESNNRIRCQPWRC-RAQEFCGQQDGIYGCH-------AQGA------------ATC 1542

Query: 821  TPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLI 880
            T S                                 GD HY +FDG  + ++  C   L 
Sbjct: 1543 TAS---------------------------------GDPHYLTFDGALHHFMGTCTYVLT 1569

Query: 881  K----SADDSDISVIAQNK-KCFDNDIVCSKSVLISVGDTEIYLND------TPYKQKQS 929
            +     + DS   V A N+ +    ++   K+V ++V D  I L          ++    
Sbjct: 1570 RPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALP 1629

Query: 930  GFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKC 989
             +  + + T +L      +V+ +    + + +D    + + V   +  +L GLCGN++  
Sbjct: 1630 VWLAQGRVTIRL---SSNLVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNN 1686

Query: 990  TSNDMTTSNNLEVRNARVFGDSWALGQCESPDETI---KPCEAHQNKFPYA-KKECSILY 1045
            + +D    +     ++   G +W L +   P   +   KP    +N    A  K C+IL 
Sbjct: 1687 SLDDNLRPDRKLAGDSMQLGAAWKLPESSEPGCFLVGGKPSSCQENSMADAWNKNCAILI 1746

Query: 1046 S--DIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRS 1103
            +    F+ C  V+   S   +C    C     GD   LC S+ AYA  C Q G +  WR+
Sbjct: 1747 NPQGPFSQCHQVVPPQSSFASCVHGQCGTK--GDTTALCRSLQAYASLCAQAGQAPAWRN 1804

Query: 1104 STVCSLDC 1111
             T C + C
Sbjct: 1805 RTFCPMRC 1812



 Score =  180 bits (456), Expect = 2e-44
 Identities = 163/706 (23%), Positives = 274/706 (38%), Gaps = 94/706 (13%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCY 119
            G+C+  G+ H+ +FDG  +  P  C+ +  K C      P + +   +  +  G+     
Sbjct: 1929 GVCQLPGESHYVSFDGSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRL 1988

Query: 120  RSISLFFSNQEEIRIYGHEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWD 177
              + +   + +     GH +  N   +TLP    I  + ++  + Y +V    G  + +D
Sbjct: 1989 HEVYIDIYDAQVTLQKGHRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFD 2048

Query: 178  GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQ--TPDDT 235
            G   + +++   + GK CG+CGN+ND + D+ ++  ++     + F NSW  +   P   
Sbjct: 2049 GNHLLEIEIPTTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSEFVNSWKDKDIDPSCQ 2108

Query: 236  KCVLTPSDFP-----NPCSSGMPA-FEAIFFKCQILLQFP-FLSCHEYIDPYLYIASCVN 288
              ++     P     NP  +   A       KC+  L+ P +  C   ID   ++  C N
Sbjct: 2109 SLLVDEQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCAN 2168

Query: 289  DLCKTDD-DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPT 347
             LC+     +  C+A   +   C   G     WR+    C  +C     + +C+  C P+
Sbjct: 2169 TLCEFGGLYQALCQALQAFGATCQSQGLKPPLWRNS-SFCPLECPAYSSYTNCLPSCSPS 2227

Query: 348  C-TFEKQCLGSNL--HCLDGCYCPDGLVMDNGTCISLENCPC-GFHGLAYSVG-SKIEQE 402
            C   + +C G+ +   C +GC C  G V+    C+    C C   HG +  +G S +   
Sbjct: 2228 CWDLDGRCEGAKVPSACAEGCICQPGYVLSEDKCVPRSQCGCKDAHGGSIPLGKSWVSSG 2287

Query: 403  CTE-CVCVGGVWNCTEQDCP---------------------VQCSVVGDSHFTTFDGRHY 440
            CTE CVC GG   C +  CP                      QCSV GD  + TFDG  Y
Sbjct: 2288 CTEKCVCTGGAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSEQCSVYGDPRYLTFDGFSY 2347

Query: 441  SFIGMCQYILVKGT-----GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLG 495
               G   Y+L+K       G +   +  +         +   + IT +    +  +V L 
Sbjct: 2348 RLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIFLQEVITTV----YGYKVQLQ 2403

Query: 496  RGGQILTS---------PNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQ 546
             G +++ +         PN+   +       TL    + L T F L + F    +   I 
Sbjct: 2404 AGLELVVNNQKMAVPYRPNEHLRV-------TLWGQRLYLVTDFELVVSFG-GRKNAVIS 2455

Query: 547  LTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRV---SSTCFAPVHVPV- 602
            L S ++    GLCG ++ N ++D + PSG +        N+W V    +    P  +P  
Sbjct: 2456 LPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTEDALLRFPRAIPAE 2515

Query: 603  ---------------VDPCNINQQNIGYAAHCDVI--HQELFAPCHIYISPGLYYQLCRH 645
                           V  C+  Q        C V+   Q  FA CH  ++P  + + C  
Sbjct: 2516 EEGQGAELGLRTGLQVSECSPEQLASNSTQACRVLADPQGPFAACHQTVAPEPFQEHCVL 2575

Query: 646  DACKC-----GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC 686
            D C            C  L+ YA LC + G  +      + C   C
Sbjct: 2576 DLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRDRTLCESPC 2621



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 98/441 (22%), Positives = 159/441 (36%), Gaps = 58/441 (13%)

Query: 1411 DVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI 1470
            + ++  CG        N    C  +     C +  +   +TFDG +       +YIL + 
Sbjct: 1126 ECQISQCGTHTVCQLKNGQYGCHPYAGTATCLVYGDPHYVTFDGRHFGFMGKCTYILAQP 1185

Query: 1471 PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLP-F 1529
             G          + N+   G+    C  K+ VT P   + + +  R+  V    V LP  
Sbjct: 1186 CGNSTDPFFRVTAKNEE-QGQEGVSCLSKVYVTLPESTVTLLK-GRRTLVGGQQVTLPAI 1243

Query: 1530 SSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDD 1589
             S+ + +  SG    + T  GL ++W    G   ++       S    GLCG  + + D+
Sbjct: 1244 PSKGVFLGASGRFVELQTEFGLRVRWD---GDQQLYVTVSSTYSGKLCGLCGNYDGNSDN 1300

Query: 1590 DLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRR-PVRNCTEHD------------CSQ 1636
            D    +G+   + E++G    SW+ ++  +   ++  V N    D            C +
Sbjct: 1301 DHLKLDGSPAGDKEELG---NSWQTDQDEDQECQKYQVVNSPSCDSSLQSSMSGPGFCGR 1357

Query: 1637 CIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             +D      F  C   V    F +   ++   F   +   C  +S     C      ++ 
Sbjct: 1358 LVD--THGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKP 1415

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHS 1752
            WR P +C ++CP   +Y  C +PC   TC +  F G        E C C  G +L     
Sbjct: 1416 WREPHFCPMACPPNSKYSLCAKPC-PDTC-HSGFSGMFCSDRCVEACECNPGFVL---SG 1470

Query: 1753 AQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCER 1812
             +CIP  +C C          GE W         YK           P C E    VCE 
Sbjct: 1471 LECIPRSQCGCLHPAGSYFKVGERW---------YK-----------PGCKE--LCVCES 1508

Query: 1813 EAEVVMGIIDKWTCCSKEVCG 1833
               +       W C ++E CG
Sbjct: 1509 NNRI---RCQPWRCRAQEFCG 1526



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 86/371 (23%), Positives = 145/371 (39%), Gaps = 47/371 (12%)

Query: 19   SGSCPYECLNGAFCSKTGTCDCQIFQA-LGTRCQIIPNMGNG-----RDGICKTWGQYHF 72
            S  C  +C+    C+  G   C  F+   G+ CQ+  +  N      +   C  +G   +
Sbjct: 2285 SSGCTEKCV----CTG-GAIQCGDFRCPSGSHCQLTSDNSNSNCVSDKSEQCSVYGDPRY 2339

Query: 73   ETFDGIYYYFPGNCSYIFAKDCGDL----EPRYTVWVHNSPKCLGSVYSCYRSISLFFSN 128
             TFDG  Y   G  +Y+  K    L    EP      +       S++     I+  +  
Sbjct: 2340 LTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSIF-LQEVITTVYGY 2398

Query: 129  QEEIRIYGHEIKKNGISLTLPQTIGQ-IFIEKLADYILVKTTFGFSLAWDGISGIYLKLS 187
            + +++  G E+  N   + +P    + + +      + + T F   +++ G     + L 
Sbjct: 2399 KVQLQA-GLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVSFGGRKNAVISLP 2457

Query: 188  EDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFP-- 245
              ++G   GLCGNY+  + +D ++     T+++  F NSW V+T D    +  P   P  
Sbjct: 2458 SMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFGNSWEVKTED--ALLRFPRAIPAE 2515

Query: 246  ----------------NPCSSGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCV 287
                            + CS    A  +    C++L   Q PF +CH+ + P  +   CV
Sbjct: 2516 EEGQGAELGLRTGLQVSECSPEQLASNST-QACRVLADPQGPFAACHQTVAPEPFQEHCV 2574

Query: 288  NDLCKTDD----DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISC 343
             DLC   D    +E  C+  + YA  C  AG  +  WRD    C   C  +    D   C
Sbjct: 2575 LDLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRDR-TLCESPCLQNPCQNDG-QC 2632

Query: 344  CPPTCTFEKQC 354
                 TF  +C
Sbjct: 2633 REQGATFTCEC 2643



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 100/427 (23%), Positives = 162/427 (37%), Gaps = 64/427 (14%)

Query: 1427 NSDICCPEWECPCR-------------------CSMLSELSIITFDGNNAALYSMASYIL 1467
            N+ I C  W C  +                   C+   +   +TFDG         +Y+L
Sbjct: 1509 NNRIRCQPWRCRAQEFCGQQDGIYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVL 1568

Query: 1468 VR-IPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLAR-KVEVDSIVV 1525
             R        ++    + N+   G +     K ++VT     I + R  +  +    + +
Sbjct: 1569 TRPCWSRSQDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVAL 1628

Query: 1526 PLPFSSQELSIEDSGSMYVITTPAGLIIKW--SHLTGIIDIHFGFRFNLSSYTEGLCGIC 1583
            P+  +   ++I  S ++ ++ T  GL +++  SHL  +           SSY   LCG+C
Sbjct: 1629 PVWLAQGRVTIRLSSNLVLLYTNFGLQVRYDGSHLVEVTVP--------SSYGGQLCGLC 1680

Query: 1584 ----NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFE----VTMRRPVRNCTEHDCS 1635
                N   DD+LR        +M+ +G    +W++ +S E    +   +P  +C E+  +
Sbjct: 1681 GNYNNNSLDDNLRPDRKLAGDSMQ-LGA---AWKLPESSEPGCFLVGGKP-SSCQENSMA 1735

Query: 1636 Q-----CIDLLNRR-IFIPCHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVALCNK 1686
                  C  L+N +  F  CH  V P+     C              C +L AY +LC +
Sbjct: 1736 DAWNKNCAILINPQGPFSQCHQVVPPQSSFASCVHGQCGTKGDTTALCRSLQAYASLCAQ 1795

Query: 1687 FDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC---LNLREDCVCKV 1743
                  WR   +C + CP G  Y PC  PC   TC +        C   L   E C C+ 
Sbjct: 1796 AGQAPAWRNRTFCPMRCPPGSSYSPCSSPC-PDTCSS--INNPRDCPKALPCAESCECQK 1852

Query: 1744 GTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCD 1803
            G IL       C+P  +C CTD        GE W        L  C  + +I   +  C 
Sbjct: 1853 GHIL---SGTSCVPLGQCGCTDPAGSYHPVGERWYTENTCTRLCTCSVHNNITCFQSTC- 1908

Query: 1804 EEPTPVC 1810
             +P  +C
Sbjct: 1909 -KPNQIC 1914



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 114/557 (20%), Positives = 203/557 (36%), Gaps = 116/557 (20%)

Query: 1281 YEPCATPCFKTCSD-------PEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCI 1333
            Y PC++PC  TCS        P+AL C      E C   C K  IL   +        C+
Sbjct: 1818 YSPCSSPCPDTCSSINNPRDCPKALPC-----AESC--ECQKGHILSGTS--------CV 1862

Query: 1334 PVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYI 1393
            P+     T   PA    P+   W   T +  T     +    + C      P   C    
Sbjct: 1863 PLGQCGCT--DPAGSYHPVGERW--YTENTCTRLCTCSVHNNITCFQSTCKPNQIC---- 1914

Query: 1394 CLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFD 1453
                      W+L+      +  C   G  V                C +  E   ++FD
Sbjct: 1915 ----------WALD-----GLLRCRASGVGV----------------CQLPGESHYVSFD 1943

Query: 1454 GNNAALYSMASYILVRIPGEIIVAHIEKCSM-NQAPSGRISGLCFKKLNVTTPIHKIIVN 1512
            G+N ++    + +LV++    +     K S  ++   G        ++ +     ++ + 
Sbjct: 1944 GSNHSIPDACTLVLVKVCHPAMALPFFKISAKHEKEEGGTEAFRLHEVYIDIYDAQVTLQ 2003

Query: 1513 RLARKVEVDSIVVPLPFSSQ--ELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRF 1570
            +   +V ++S  V LP  SQ   +S++ S    ++    G+ +K+     +++I      
Sbjct: 2004 K-GHRVLINSKQVTLPAISQIPGVSVKSSSIYSIVNIKIGVQVKFDG-NHLLEIEIP--- 2058

Query: 1571 NLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESW---EIEKSFEVTM-- 1622
              ++Y   +CG+C   N++ +D+L M +  +  +  +   F+ SW   +I+ S +  +  
Sbjct: 2059 --TTYYGKVCGMCGNFNDEEEDELMMPSDEVANSDSE---FVNSWKDKDIDPSCQSLLVD 2113

Query: 1623 ---------RRPVRNCTEHDC----SQCIDLLNRRIFIPCHDKVSPEDF---CEKMWINY 1666
                       P  NC   D      +C   L   ++  C  ++    F   C      +
Sbjct: 2114 EQQIPAEQQENPSGNCRAADLRRAREKCEAALRAPVWAQCASRIDLTPFLVDCANTLCEF 2173

Query: 1667 TYFWNYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTC--LN 1723
               +   C AL A+ A C    +    WR   +C L CP    Y  C+  C + +C  L+
Sbjct: 2174 GGLYQALCQALQAFGATCQSQGLKPPLWRNSSFCPLECPAYSSYTNCLPSC-SPSCWDLD 2232

Query: 1724 QWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIW------ 1777
                G        E C+C+ G +L      +C+P  +C C D+       G+ W      
Sbjct: 2233 GRCEGAKVPSACAEGCICQPGYVLSED---KCVPRSQCGCKDAHGGSIPLGKSWVSSGCT 2289

Query: 1778 -----NGGIDECTLYKC 1789
                  GG  +C  ++C
Sbjct: 2290 EKCVCTGGAIQCGDFRC 2306



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 69/343 (20%), Positives = 127/343 (37%), Gaps = 60/343 (17%)

Query: 1440 RCSMLSELSIITFDGNNAALYSMASYILVR----IPGEIIVAHIEKCSMNQAPSGRISGL 1495
            +CS+  +   +TFDG +  L    +Y+L++    +P  +    +E  +    P   I   
Sbjct: 2330 QCSVYGDPRYLTFDGFSYRLQGRMTYVLIKTVDVLPEGVEPLLVEGRNKMDPPRSSI--- 2386

Query: 1496 CFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-LSIEDSGSMYVITTPAGLIIK 1554
             F +  +TT     +  +   ++ V++  + +P+   E L +   G    + T   L++ 
Sbjct: 2387 -FLQEVITTVYGYKVQLQAGLELVVNNQKMAVPYRPNEHLRVTLWGQRLYLVTDFELVVS 2445

Query: 1555 WSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEI 1614
            +    G  +              GLCG  +++  +D+ + +G +  N+   G    SWE+
Sbjct: 2446 FG---GRKNAVISLPSMYEGLVSGLCGNYDKNRKNDMMLPSGALTQNLNTFG---NSWEV 2499

Query: 1615 EKSFEVTMRRP---------------------VRNCT-----EHDCSQCIDLLN-RRIFI 1647
             K+ +  +R P                     V  C+      +    C  L + +  F 
Sbjct: 2500 -KTEDALLRFPRAIPAEEEGQGAELGLRTGLQVSECSPEQLASNSTQACRVLADPQGPFA 2558

Query: 1648 PCHDKVSPEDFCEKMWINYTYFWN------YECDALSAYVALCNKFDICIQ-WRTPDYCS 1700
             CH  V+PE F E   ++     +        C  LS Y  LC +    +  WR    C 
Sbjct: 2559 ACHQTVAPEPFQEHCVLDLCSAQDPREQEELRCQVLSGYAILCQEAGAALAGWRDRTLCE 2618

Query: 1701 LSCPEGKEYQPCVRPCEAR------TCLNQWFYGHTSCLNLRE 1737
              C +     PC    + R      TC  +  YG   C+  R+
Sbjct: 2619 SPCLQ----NPCQNDGQCREQGATFTCECEVGYGGGLCMEPRD 2657



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 26/99 (26%), Positives = 33/99 (33%), Gaps = 22/99 (22%)

Query: 1703 CPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNL-REDCVCKVGTILHRPHSAQCIPEKEC 1761
            CP    Y+ C  P   ++          SC  L RE CVC  G +    H   CI    C
Sbjct: 1044 CPPNARYESCACPASCKS-------PRPSCGPLCREGCVCNPGFLFSDNH---CIQASSC 1093

Query: 1762 ACTDSEDQPRTAGE-----------IWNGGIDECTLYKC 1789
             C  + D      E            W G   EC + +C
Sbjct: 1094 NCFYNNDYYEPGAEWFSPNCTEHCRCWPGSRVECQISQC 1132


>gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo
            sapiens]
          Length = 3003

 Score =  319 bits (818), Expect = 2e-86
 Identities = 290/1160 (25%), Positives = 472/1160 (40%), Gaps = 170/1160 (14%)

Query: 45   ALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCG--DLEP 99
            A G RCQ++            +C+  G  H+ TFDG  Y   G CSY   + C   D  P
Sbjct: 450  AAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLP 509

Query: 100  RYTVWVHNSPKC--------LGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQT 151
             ++V   N  +         L +V +   S+SL    + E+     + +++ + ++L + 
Sbjct: 510  AFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSL---TRGEVGFVLVDNQRSRLPVSLSE- 565

Query: 152  IGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFII 211
             G++ + +     +V+  FG  + +D    + L L    + + CGLCGNYN   +DDF+ 
Sbjct: 566  -GRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLT 624

Query: 212  LQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFK----CQIL-- 265
                   D   FA+SW +   D     L      N C +  P  +A  ++    C +L  
Sbjct: 625  PDGALAPDAVEFASSWKLDDGD----YLCEDGCQNNCPACTPG-QAQHYEGDRLCGMLTK 679

Query: 266  LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEYARACSHAGYPIQDWRDDF 324
            L  PF  CH+ +DP  ++  CV DLC    +  + CR  + YA+AC   G  + DWR   
Sbjct: 680  LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRS-- 737

Query: 325  PA-CTDKCDDSFVHRDCISCCPPTC---TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCIS 380
            PA C   C  +  +  C   CP +C        C G    C++GC C  G V   G C+ 
Sbjct: 738  PANCPLSCPANSRYELCGPACPTSCNGAAAPSNCSGR--PCVEGCVCLPGFVASGGACVP 795

Query: 381  LENCPCGFHGLAYSVGSKI--EQEC-TECVCVGGVWNCT---EQDCPV--QCSV------ 426
              +C C F GL  + G ++  ++ C   C C G     T   +Q CP   +CSV      
Sbjct: 796  ASSCGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLG 855

Query: 427  -----------VGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLV 475
                        GD H+ +FDGR + F+G C Y+LV   G++      +     ++ G  
Sbjct: 856  CYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQ 915

Query: 476  CLQSITLILEDDFNKQVTLGR--GGQILTS------PNQGFNLNGIVEIQTLSSLFILLK 527
             +     +  +    +V + R   GQ+L        P Q    +G V++        +++
Sbjct: 916  TVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQA--ADGQVQV-FRQGRDAVVR 972

Query: 528  TTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANA 587
            T FGL + +  +  R+  ++ S++     GLCG FNG+  DD     G          N+
Sbjct: 973  TDFGLTVTYDWNA-RVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNS 1031

Query: 588  WRVSST--CFA--PVHVPVVDPCNINQQNIGYAAHCDVIHQEL--FAPCHIYISPGLYYQ 641
            W+  +   C A  P   P +D  ++  Q +     C ++      F  CH  + P    +
Sbjct: 1032 WQEETRPGCGATEPGDCPKLD--SLVAQQLQSKNECGILADPKGPFRECHSKLDPQGAVR 1089

Query: 642  LCRHDACKC--GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFC 699
             C +D C     S  LC+ALA YA  C   G  +        C + C     Y  CS  C
Sbjct: 1090 DCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEACSYGC 1149

Query: 700  LHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELI--- 756
              SC  L  P  C  +C EGC C EG  +  +   C+P+  C C ++G+ + PG+     
Sbjct: 1150 PLSCGDLPVPGGCGSECHEGCVCDEG--FALSGESCLPLASCGCVHQGTYHPPGQTFYPG 1207

Query: 757  PTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAM 816
            P    LC C  G                                  G V+CE+  ++   
Sbjct: 1208 PGCDSLCHCQEG----------------------------------GLVSCES--SSCGP 1231

Query: 817  NFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQ 876
            +  C PS   + GCV                   + C   GD HY +FDG  +D++  C 
Sbjct: 1232 HEACQPSGGSL-GCVAVGS---------------STCQASGDPHYTTFDGRRFDFMGTCV 1275

Query: 877  VFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFF 932
              L ++          +V+ +N    +  +  ++ + + V +  + L    +K   +G  
Sbjct: 1276 YVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVD 1335

Query: 933  LE-----NKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFD 987
            ++          +  + G  +V+   +  + + +D    + + V   +  ++ GLCGN++
Sbjct: 1336 MKLPVVLANGQIRASQHGSDVVIE-TDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYN 1394

Query: 988  KCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCE------AHQNKFP------ 1035
                +D    N  +  NA  FG+SW     +SP     PC          +K P      
Sbjct: 1395 GDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKK 1454

Query: 1036 YAKKE-CSILYSDI--FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKC 1092
            Y K+E C +L S     +SC  ++D     K+C  D C    GG+   LC++I AY   C
Sbjct: 1455 YQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLG--GGNLSILCSNIHAYVSAC 1512

Query: 1093 CQEGISIH-WRSSTVCSLDC 1111
               G  +  WR+ T C ++C
Sbjct: 1513 QAAGGHVEPWRTETFCPMEC 1532



 Score =  305 bits (782), Expect = 3e-82
 Identities = 307/1192 (25%), Positives = 459/1192 (38%), Gaps = 224/1192 (18%)

Query: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 1646 HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 1696

Query: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 1697 YVLATTGCPGVSTQGLTPFTVTTKNQNR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 1754

Query: 142  ----NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSC 195
                NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  C
Sbjct: 1755 RVCVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVC 1814

Query: 196  GLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-------KCVLTPSD----- 243
            GLCGN +   ++D +         I ++  SW     D          C   P D     
Sbjct: 1815 GLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQY 1874

Query: 244  ----FPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ET 298
                F  P +SG                 PF +CH ++ P  +   CV D+C    D + 
Sbjct: 1875 EGPGFCGPLASGTGG--------------PFTTCHAHVPPESFFKGCVLDVCMGGGDRDI 1920

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEK 352
             C+A   Y  AC  AG  I+DWR     C   C ++  +  C   CP +C      T   
Sbjct: 1921 LCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPA 1979

Query: 353  QCLGSNLHCLDGCYCPDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVC 408
             C G    C++GC C  G V+    C+ L N C C  +G  +  GS+   +  C++ C C
Sbjct: 1980 VCEGP---CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRC 2036

Query: 409  V--GGVWNCTEQDC-----------------PV---QCSVVGDSHFTTFDGRHYSFIGMC 446
               GG   CT   C                 PV   +C   GD H+ T DG  + F G C
Sbjct: 2037 GPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTC 2096

Query: 447  QYILVKGT-----GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR----- 496
            +Y+L         G + FT+T+       +  +   +S+TL +   +N  +TL       
Sbjct: 2097 EYLLSAPCHGPPLGAENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRK 2152

Query: 497  ---GGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWK 552
                G  +  P   F L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+ 
Sbjct: 2153 LQVDGVFVALP---FQLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYA 2206

Query: 553  RRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQ 610
                GLCG +N +  DD  +  G   G        W+V     C   V  P   PC   Q
Sbjct: 2207 ASLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQ 2258

Query: 611  Q-NIGYAAHCDVIHQE--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYL 665
            Q + G    C VI       APCH  + P  Y+Q C  DAC+       LC A+A Y   
Sbjct: 2259 QESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAA 2318

Query: 666  CGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEG 725
            C   G  +    +  FC + C     Y  C   C  SC SLS+PE C   C EGC C  G
Sbjct: 2319 CQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG 2378

Query: 726  KFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICP 785
              +  + + CVP+  C C + G  Y  GE+                              
Sbjct: 2379 --FVLSGDTCVPVGQCGCLHDGRYYPLGEVF----------------------------- 2407

Query: 786  EGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RG 840
                     +P PE       CE  C        C P     C  G  C P   CR   G
Sbjct: 2408 ---------YPGPE-------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDG 2444

Query: 841  MFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKK 896
            +  C    C   C   G  HY + DG  YD    C   L +       D D S++ +   
Sbjct: 2445 VQACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNA 2503

Query: 897  CFDND--IVCSKSVLISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIV 949
              D    +V     ++S+   +    D      P    +     E ++           +
Sbjct: 2504 AGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------M 2552

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
            V    K + +L+D    + + +   ++ +L GLCGNF+   S+D    N     +   FG
Sbjct: 2553 VLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFG 2612

Query: 1010 DSW-ALGQCESPDETIKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTS 1060
             +W A G  +   E   P     C A +   PY   E C  L +    FA+C+ V+  + 
Sbjct: 2613 AAWRAPGSSKGCGEGCGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSE 2671

Query: 1061 FAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
            + + C  D C     GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 2672 YFRQCVYDLCAQK--GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 2721



 Score =  302 bits (774), Expect = 2e-81
 Identities = 292/1190 (24%), Positives = 462/1190 (38%), Gaps = 157/1190 (13%)

Query: 22   CPYECL-NGAFCSKTGTCDCQIFQALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDG 77
            C   C  NGA  +   TC  +     G RC +   +      R G C+  G  H+ +FDG
Sbjct: 820  CQRRCTCNGA--THQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGTCQGSGDPHYVSFDG 877

Query: 78   IYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRI- 134
              + F G C+Y+    CG     P + V V N  +  GS    Y       +   ++ + 
Sbjct: 878  RRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHR--GSQTVSYTRAVRVEARGVKVAVR 935

Query: 135  --YGHEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDH 190
              Y  ++  + +   LP     GQ+ + +     +V+T FG ++ +D  + +  K+   +
Sbjct: 936  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDWNARVTAKVPSSY 995

Query: 191  KGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT-PSDFPNPCS 249
                CGLCGN+N   +DD  +       +   F NSW  +T     C  T P D P   S
Sbjct: 996  AEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPG--CGATEPGDCPKLDS 1053

Query: 250  SGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEY 306
                  ++   +C IL   + PF  CH  +DP   +  CV D C         C A   Y
Sbjct: 1054 LVAQQLQS-KNECGILADPKGPFRECHSKLDPQGAVRDCVYDRCLLPGQSGPLCDALATY 1112

Query: 307  ARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCY 366
            A AC  AG  +  WR +   C   C     +  C   CP +C       G    C +GC 
Sbjct: 1113 AAACQAAGATVHPWRSE-ELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCV 1171

Query: 367  CPDGLVMDNGTCISLENCPCGFHGLAYSVGSKI--EQECTE-CVC-VGGVWNCTEQDC-- 420
            C +G  +   +C+ L +C C   G  +  G        C   C C  GG+ +C    C  
Sbjct: 1172 CDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGLVSCESSSCGP 1231

Query: 421  -----------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK--GT--GKDKF 459
                                C   GD H+TTFDGR + F+G C Y+L +  GT  G  +F
Sbjct: 1232 HEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRF 1291

Query: 460  TITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNL---NGIVEI 516
             + LQ+     N G V +  +  +   +F  ++   +    +   +    +   NG +  
Sbjct: 1292 AV-LQENVAWGN-GRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRA 1349

Query: 517  QTLSSLFILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLCGTFNGNIRDDFLSPS 574
                S  ++++T FGL++ + +     Y+++T    + ++  GLCG +NG+ +DDF  P+
Sbjct: 1350 SQHGS-DVVIETDFGLRVAYDL---VYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPN 1405

Query: 575  GMIEGTPQLHANAWR---VSSTCFAPVHVPVVDPCNIN--------QQNIGYAAHCDVIH 623
            G   G      N+W      S C  P   P      I         ++       C ++ 
Sbjct: 1406 GSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLS 1465

Query: 624  QEL--FAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPID-FRTQ 678
                  + CH  + P    + C  D C  G   S LC+ +  Y   C   G  ++ +RT+
Sbjct: 1466 SPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTE 1525

Query: 679  ISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPI 738
             +FC + C     Y  C+  C   C +LS+P QC D CAEGC C  G  Y      CVPI
Sbjct: 1526 -TFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNG--QACVPI 1582

Query: 739  FHCRCHYRGSVYQPGE--LIPTPSGLCQCSNGT-VKCDELATPSAVHICPEGKEYFDCRF 795
              C C++ G  Y+P +  LI      C C  G  + C E       H C  G+    C+ 
Sbjct: 1583 QQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKGMVCQE-------HSCKPGQV---CQ- 1631

Query: 796  PDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAP-GVCR-RGMFNCTYYPCPAVC 853
                 P+GG+             +C    PC  G  C P   C+ +G          A C
Sbjct: 1632 -----PSGGI------------LSCVTKDPC-HGVTCRPQETCKEQGGQGVCLPNYEATC 1673

Query: 854  TIYGDRHYYSFDGLEYDYISDCQVFL-------IKSADDSDISVIAQNKKCFDNDIVCSK 906
             ++GD HY+SFDG ++D+   C   L       + +   +  +V  +N+   +  +   +
Sbjct: 1674 WLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVR 1733

Query: 907  SVLISVGDTEI----------------YLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVV 950
             V ++   T I                 L   P         +   ++  L  A +    
Sbjct: 1734 VVTVAALGTNISIHKDEIGKVRVCVNGVLTALPVSVADGRISVAQGASKALLVADF---- 1789

Query: 951  YFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGD 1010
                  + + +D    + + +   +   + GLCGN D+  +ND    N     +  ++G 
Sbjct: 1790 -----GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGG 1844

Query: 1011 SW--------ALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFA 1062
            SW           +C     T       Q + P      +      F +C   +   SF 
Sbjct: 1845 SWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLASGTGGPFTTCHAHVPPESFF 1904

Query: 1063 KNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
            K C  D C    GGD + LC ++A+Y   C   G+ I  WR+   C + C
Sbjct: 1905 KGCVLDVCMG--GGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 1952



 Score =  254 bits (648), Expect = 9e-67
 Identities = 226/841 (26%), Positives = 342/841 (40%), Gaps = 99/841 (11%)

Query: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 2024 FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 2077

Query: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 2078 GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 2136

Query: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 2137 QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 2196

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 2197 VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 2248

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 2249 PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 2306

Query: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 2307 GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 2364

Query: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 2365 CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 2424

Query: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 2425 VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 2483

Query: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 2484 QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 2533

Query: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 2534 VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 2590

Query: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619
            GN  DDF+ P+G    + +    AWR   SS        P   P  + ++   Y ++  C
Sbjct: 2591 GNWSDDFVLPNGSAASSVETFGAAWRAPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 2650

Query: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 2651 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 2710

Query: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 2711 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 2768

Query: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 2769 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 2827

Query: 793  C 793
            C
Sbjct: 2828 C 2828



 Score =  201 bits (512), Expect = 5e-51
 Identities = 195/769 (25%), Positives = 303/769 (39%), Gaps = 120/769 (15%)

Query: 406  CVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQK 465
            C  VGG   C  +   V C   GD H+TTFDGR Y  +G C Y +V+   +D        
Sbjct: 455  CQVVGGKAGCVAESTAV-CRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSV 513

Query: 466  APCEQNLGLVCLQSITLILEDDFNKQVTLGRG--GQILTSPNQGFNLNGIVEIQTL---- 519
                ++ G   +  + L+    ++  V+L RG  G +L   NQ   L   +    L    
Sbjct: 514  EAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVD-NQRSRLPVSLSEGRLRVYQ 572

Query: 520  SSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG 579
            S    +++  FGL + +  D + + + L + ++ +  GLCG +NG+  DDFL+P G +  
Sbjct: 573  SGPRAVVELVFGLVVTYDWDCQ-LALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 631

Query: 580  TPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNI--GYAAH------CDVIHQ--ELFAP 629
                 A++W++    +        D C  N      G A H      C ++ +    FA 
Sbjct: 632  DAVEFASSWKLDDGDYL-----CEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAV 686

Query: 630  CHIYISPGLYYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVVC 686
            CH  + P  + + C +D C  G     LC  L+ YA  C + G+ + D+R+  + C + C
Sbjct: 687  CHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPAN-CPLSC 745

Query: 687  QKGMLYHHCSSFCLHSCISLSSPEQCSD-DCAEGCNCPEGKFYEDTLNFCVPIFHCRCHY 745
                 Y  C   C  SC   ++P  CS   C EGC C  G  +  +   CVP   C C +
Sbjct: 746  PANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPG--FVASGGACVPASSCGCTF 803

Query: 746  RGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGV 805
            +G    PG+               V  DEL                              
Sbjct: 804  QGLQLAPGQ--------------EVWADELCQRRC------------------------- 824

Query: 806  NCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCP-AVCTIYGDRHYYSF 864
                TC       TC     C +G  C+    + G+  C  YP     C   GD HY SF
Sbjct: 825  ----TCNGATHQVTCRDKQSCPAGERCS---VQNGLLGC--YPDRFGTCQGSGDPHYVSF 875

Query: 865  DGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLN 920
            DG  +D++  C   L+ S   +       V+ +N+      +  +++V +     ++ + 
Sbjct: 876  DGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVR 935

Query: 921  DTPYKQK------QSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQ 974
                 Q       Q   F       Q+++ G   VV   +  +T+ +D    +  KV   
Sbjct: 936  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVR-TDFGLTVTYDWNARVTAKVPSS 994

Query: 975  WKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW-----------ALGQCESPDET 1023
            +   L GLCGNF+   ++D+      +  NA  FG+SW             G C   D  
Sbjct: 995  YAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPGCGATEPGDCPKLDSL 1054

Query: 1024 IKPCEAHQNKFPYAKKECSILY--SDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECL 1081
            +    A Q +   +K EC IL      F  C + +D     ++C  D   C L G    L
Sbjct: 1055 V----AQQLQ---SKNECGILADPKGPFRECHSKLDPQGAVRDCVYD--RCLLPGQSGPL 1105

Query: 1082 CTSIAAYAYKCCQEGISIH-WRSSTVCSLDCEYYNEGLGEGPYMLASYG 1129
            C ++A YA  C   G ++H WRS  +C L C  ++       Y   SYG
Sbjct: 1106 CDALATYAAACQAAGATVHPWRSEELCPLSCPPHSH------YEACSYG 1148



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 97/406 (23%), Positives = 143/406 (35%), Gaps = 47/406 (11%)

Query: 1431 CCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGE--IIVAHIEKCSMNQAP 1488
            C  E    CR     +    TFDG    +    SY +V +  E   + A   +       
Sbjct: 464  CVAESTAVCRAQ--GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRG 521

Query: 1489 SGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVV-------PLPFSSQELSIEDSGS 1541
            S R+S +    + V    H + + R     EV  ++V       P+  S   L +  SG 
Sbjct: 522  SRRVSYVGL--VTVRAYSHSVSLTR----GEVGFVLVDNQRSRLPVSLSEGRLRVYQSGP 575

Query: 1542 MYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITN 1601
              V+    GL++ +        +             GLCG  N DP DD    +G +  +
Sbjct: 576  RAVVELVFGLVVTYDW---DCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAPD 632

Query: 1602 MEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI----------FIPCHD 1651
              +   F  SW+++    +       NC      Q       R+          F  CHD
Sbjct: 633  AVE---FASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAVCHD 689

Query: 1652 KVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGK 1707
             + P  F E+   +           C  LSAY   C +  I +  WR+P  C LSCP   
Sbjct: 690  TLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPANCPLSCPANS 749

Query: 1708 EYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSE 1767
             Y+ C   C   +C       + S     E CVC  G +        C+P   C CT   
Sbjct: 750  RYELCGPACPT-SCNGAAAPSNCSGRPCVEGCVCLPGFV---ASGGACVPASSCGCTFQG 805

Query: 1768 DQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDC-DEEPTPVCER 1812
             Q     E+W    DE    +C  NG+   +   C D++  P  ER
Sbjct: 806  LQLAPGQEVW---ADELCQRRCTCNGATHQV--TCRDKQSCPAGER 846



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 100/440 (22%), Positives = 165/440 (37%), Gaps = 73/440 (16%)

Query: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 2418 ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 2477

Query: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 2478 CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 2527

Query: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 2528 TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 2583

Query: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635
              GLCG  N +  DD  + NG+  +++E  G    +W    S     +     C    C 
Sbjct: 2584 --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRAPGS----SKGCGEGCGPQGCP 2634

Query: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 2635 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 2694

Query: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 2695 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 2752

Query: 1737 EDCVCKVGTILHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 2753 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 2806

Query: 1796 IPIEPDCDEEPTPVCEREAE 1815
                  C   P  VCE +AE
Sbjct: 2807 TCQAAGC--PPGRVCEVKAE 2824



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 95/400 (23%), Positives = 146/400 (36%), Gaps = 56/400 (14%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   ++FDG         +Y+LV   G+       +  +     G  +    + +
Sbjct: 864  CQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAV 923

Query: 1501 NVTTPIHKIIVNR-LARKVEVDSIVVPLPFSSQELSIE--DSGSMYVITTPAGLIIKW-- 1555
             V     K+ V R    +V VD ++  LPF + +  ++    G   V+ T  GL + +  
Sbjct: 924  RVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDW 983

Query: 1556 -SHLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIES 1611
             + +T  +          SSY E LCG+C   N DP DDL ++ G    N    G    S
Sbjct: 984  NARVTAKVP---------SSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFG---NS 1031

Query: 1612 WEIEKSFEVTMRRPVRNCTEH-DCSQCIDLLNRRI---------------FIPCHDKVSP 1655
            W+ E        RP    TE  DC +   L+ +++               F  CH K+ P
Sbjct: 1032 WQEET-------RPGCGATEPGDCPKLDSLVAQQLQSKNECGILADPKGPFRECHSKLDP 1084

Query: 1656 EDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQP 1711
            +        +           CDAL+ Y A C      +  WR+ + C LSCP    Y+ 
Sbjct: 1085 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1144

Query: 1712 CVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPR 1771
            C   C   +C +    G        E CVC  G  L       C+P   C C   +    
Sbjct: 1145 CSYGCPL-SCGDLPVPGGCGS-ECHEGCVCDEGFAL---SGESCLPLASCGCV-HQGTYH 1198

Query: 1772 TAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
              G+ +  G    +L  C E G +      C   P   C+
Sbjct: 1199 PPGQTFYPGPGCDSLCHCQEGGLVSCESSSCG--PHEACQ 1236



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 87/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 2074 CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 2132

Query: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 2133 SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 2192

Query: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 2193 G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 2235

Query: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 2236 VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 2294

Query: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 2295 LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 2354

Query: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
                     G  S    RE CVC  G +L       C+P  +C C
Sbjct: 2355 SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 2394



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 89/390 (22%), Positives = 144/390 (36%), Gaps = 54/390 (13%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI--PG-------EII 1475
            Q    +C P +E  C   +  +    +FDG         +Y+L     PG          
Sbjct: 1659 QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFT 1716

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-- 1533
            V    +   N A S  +  +    L     IHK  + ++  +V V+ ++  LP S  +  
Sbjct: 1717 VTTKNQNRGNPAVS-YVRVVTVAALGTNISIHKDEIGKV--RVCVNGVLTALPVSVADGR 1773

Query: 1534 LSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDP 1587
            +S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P
Sbjct: 1774 ISVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNP 1824

Query: 1588 DDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CI 1638
            ++D    NGT+  +   I ++  SW       +     R     C E    Q      C 
Sbjct: 1825 NNDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCG 1881

Query: 1639 DLLNRR--IFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             L +     F  CH  V PE F +   ++           C AL++YVA C    + I+ 
Sbjct: 1882 PLASGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIED 1941

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPH 1751
            WR    C ++CPE   Y+ C  PC A             C     E C C  G +L    
Sbjct: 1942 WRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---S 1998

Query: 1752 SAQCIP-EKECACTDSEDQPRTAGEIWNGG 1780
            + +C+P    C C  +        E W  G
Sbjct: 1999 ADRCVPLNNGCGCWANGTYHEAGSEFWADG 2028



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 112/530 (21%), Positives = 177/530 (33%), Gaps = 113/530 (21%)

Query: 1279 WRYEP-CATPC-----FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDC 1332
            WR E  C   C     ++ CS    L+C  LP   GC   C +  + DE     +    C
Sbjct: 1126 WRSEELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCVCDEGF--ALSGESC 1183

Query: 1333 IPVIPT----EPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYD 1388
            +P+       + T  PP +   P                       G  C     D +  
Sbjct: 1184 LPLASCGCVHQGTYHPPGQTFYP-----------------------GPGC-----DSLCH 1215

Query: 1389 CSQYICLNMEWQLYNWSLNC-PKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSEL 1447
            C +   ++ E      S +C P +   P  G  G         C       C+ S   + 
Sbjct: 1216 CQEGGLVSCE------SSSCGPHEACQPSGGSLG---------CVAVGSSTCQAS--GDP 1258

Query: 1448 SIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIH 1507
               TFDG          Y+L +  G     H           G       + + V     
Sbjct: 1259 HYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANF 1318

Query: 1508 KIIVNRLARKVEVDSIVVPLP--FSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIH 1565
             + + +   KV V+ + + LP   ++ ++     GS  VI T  GL + +       D+ 
Sbjct: 1319 TLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAY-------DLV 1371

Query: 1566 FGFRFNL-SSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVT 1621
            +  R  +  +Y + +CG+C   N DP DD +  NG+   N  + G    SWE     EV 
Sbjct: 1372 YYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGSQAGNANEFG---NSWE-----EVV 1423

Query: 1622 MRRPVRNCT-----EHDC---SQCIDLLNRRI---------------FIPCHDKVSPEDF 1658
               P    T       DC    +C   L ++                   CH  V P+  
Sbjct: 1424 PDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGP 1483

Query: 1659 CEKMWINYTYFW---NYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVR 1714
             +    +        +  C  + AYV+ C      ++ WRT  +C + CP    Y+ C  
Sbjct: 1484 LKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCAD 1543

Query: 1715 PCE-ARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
             C    + L+        C    E C C  G +    +   C+P ++C C
Sbjct: 1544 TCSLGCSALSAPPQCQDGC---AEGCQCDSGFLY---NGQACVPIQQCGC 1587



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 2793 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 2852

Query: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 2853 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 2905

Query: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 2906 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 2964

Query: 191  KGKSCGLCGNYNDIQSDDFIILQE 214
             GK CG CGN++  Q++D+   QE
Sbjct: 2965 AGKLCGACGNFDGDQTNDWHDSQE 2988


>gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]
          Length = 5405

 Score =  319 bits (818), Expect = 2e-86
 Identities = 290/1160 (25%), Positives = 472/1160 (40%), Gaps = 170/1160 (14%)

Query: 45   ALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCG--DLEP 99
            A G RCQ++            +C+  G  H+ TFDG  Y   G CSY   + C   D  P
Sbjct: 450  AAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLP 509

Query: 100  RYTVWVHNSPKC--------LGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQT 151
             ++V   N  +         L +V +   S+SL    + E+     + +++ + ++L + 
Sbjct: 510  AFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSL---TRGEVGFVLVDNQRSRLPVSLSE- 565

Query: 152  IGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFII 211
             G++ + +     +V+  FG  + +D    + L L    + + CGLCGNYN   +DDF+ 
Sbjct: 566  -GRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLT 624

Query: 212  LQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFK----CQIL-- 265
                   D   FA+SW +   D     L      N C +  P  +A  ++    C +L  
Sbjct: 625  PDGALAPDAVEFASSWKLDDGD----YLCEDGCQNNCPACTPG-QAQHYEGDRLCGMLTK 679

Query: 266  LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEYARACSHAGYPIQDWRDDF 324
            L  PF  CH+ +DP  ++  CV DLC    +  + CR  + YA+AC   G  + DWR   
Sbjct: 680  LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRS-- 737

Query: 325  PA-CTDKCDDSFVHRDCISCCPPTC---TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCIS 380
            PA C   C  +  +  C   CP +C        C G    C++GC C  G V   G C+ 
Sbjct: 738  PANCPLSCPANSRYELCGPACPTSCNGAAAPSNCSGR--PCVEGCVCLPGFVASGGACVP 795

Query: 381  LENCPCGFHGLAYSVGSKI--EQEC-TECVCVGGVWNCT---EQDCPV--QCSV------ 426
              +C C F GL  + G ++  ++ C   C C G     T   +Q CP   +CSV      
Sbjct: 796  ASSCGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLG 855

Query: 427  -----------VGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLV 475
                        GD H+ +FDGR + F+G C Y+LV   G++      +     ++ G  
Sbjct: 856  CYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQ 915

Query: 476  CLQSITLILEDDFNKQVTLGR--GGQILTS------PNQGFNLNGIVEIQTLSSLFILLK 527
             +     +  +    +V + R   GQ+L        P Q    +G V++        +++
Sbjct: 916  TVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQA--ADGQVQV-FRQGRDAVVR 972

Query: 528  TTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANA 587
            T FGL + +  +  R+  ++ S++     GLCG FNG+  DD     G          N+
Sbjct: 973  TDFGLTVTYDWNA-RVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNS 1031

Query: 588  WRVSST--CFA--PVHVPVVDPCNINQQNIGYAAHCDVIHQEL--FAPCHIYISPGLYYQ 641
            W+  +   C A  P   P +D  ++  Q +     C ++      F  CH  + P    +
Sbjct: 1032 WQEETRPGCGATEPGDCPKLD--SLVAQQLQSKNECGILADPKGPFRECHSKLDPQGAVR 1089

Query: 642  LCRHDACKC--GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFC 699
             C +D C     S  LC+ALA YA  C   G  +        C + C     Y  CS  C
Sbjct: 1090 DCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEACSYGC 1149

Query: 700  LHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELI--- 756
              SC  L  P  C  +C EGC C EG  +  +   C+P+  C C ++G+ + PG+     
Sbjct: 1150 PLSCGDLPVPGGCGSECHEGCVCDEG--FALSGESCLPLASCGCVHQGTYHPPGQTFYPG 1207

Query: 757  PTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAM 816
            P    LC C  G                                  G V+CE+  ++   
Sbjct: 1208 PGCDSLCHCQEG----------------------------------GLVSCES--SSCGP 1231

Query: 817  NFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQ 876
            +  C PS   + GCV                   + C   GD HY +FDG  +D++  C 
Sbjct: 1232 HEACQPSGGSL-GCVAVGS---------------STCQASGDPHYTTFDGRRFDFMGTCV 1275

Query: 877  VFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFF 932
              L ++          +V+ +N    +  +  ++ + + V +  + L    +K   +G  
Sbjct: 1276 YVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVD 1335

Query: 933  LE-----NKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFD 987
            ++          +  + G  +V+   +  + + +D    + + V   +  ++ GLCGN++
Sbjct: 1336 MKLPVVLANGQIRASQHGSDVVIE-TDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYN 1394

Query: 988  KCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCE------AHQNKFP------ 1035
                +D    N  +  NA  FG+SW     +SP     PC          +K P      
Sbjct: 1395 GDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKK 1454

Query: 1036 YAKKE-CSILYSDI--FASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKC 1092
            Y K+E C +L S     +SC  ++D     K+C  D C    GG+   LC++I AY   C
Sbjct: 1455 YQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLG--GGNLSILCSNIHAYVSAC 1512

Query: 1093 CQEGISIH-WRSSTVCSLDC 1111
               G  +  WR+ T C ++C
Sbjct: 1513 QAAGGHVEPWRTETFCPMEC 1532



 Score =  315 bits (808), Expect = 2e-85
 Identities = 296/1191 (24%), Positives = 469/1191 (39%), Gaps = 156/1191 (13%)

Query: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 2022 FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 2075

Query: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 2076 GDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 2134

Query: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181
               N        +  +++ +G+ +TLP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 2135 QIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 2194

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240
            + L++   + G  CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 2195 VRLRVPAAYAGSLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 2246

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 2247 PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 2304

Query: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356
              C A   Y  AC  AG  +++WR  DF  C  +C     +  C   CP +C       G
Sbjct: 2305 GLCPAVATYVAACQAAGAQLREWRRPDF--CPFQCPAHSHYELCGDSCPGSCPSLSAPEG 2362

Query: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQE--CTE-CVC-VGGV 412
                C +GC C  G V+   TC+ +  C C      Y +G        C   C C  GG 
Sbjct: 2363 CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGE 2422

Query: 413  WNCTEQDC-------------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK- 452
             +C    C                      C   GD H+TTFDGR + F+G C Y+L + 
Sbjct: 2423 VSCEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGRRFDFMGTCVYVLAQT 2482

Query: 453  -GT--GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFN 509
             GT  G  +F + LQ+     N G V +  +  +   +F  ++   +    +   +    
Sbjct: 2483 CGTRPGLHRFAV-LQENVAWGN-GRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLP 2540

Query: 510  L---NGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLCGTFNG 564
            +   NG +      S  ++++T FGL++ + +     Y+++T    + +   GLCG +NG
Sbjct: 2541 VVLANGQIRASQHGS-DVVIETDFGLRVAYDL---VYYVRVTVPGNYYQLMCGLCGNYNG 2596

Query: 565  NIRDDFLSPSGMIEGTPQLHANAWR---VSSTCFAPVHVPVVDPCNINQQNIGYAAHCDV 621
            + +DDF  P+G   G      N+W      S C  P   P      I  +          
Sbjct: 2597 DPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCPPGSEGCIPSEECPPELEKKY 2656

Query: 622  IHQEL----------FAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQH 669
              +E            + CH  + P    + C  D C  G   S LC+ +  Y   C   
Sbjct: 2657 QKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAA 2716

Query: 670  GVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYE 729
            G  ++     +FC + C +   Y  C+  C   C +LS+P QC D CAEGC C  G  Y 
Sbjct: 2717 GGQVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQCDSGFLYN 2776

Query: 730  DTLNFCVPIFHCRCHYRGSVYQPGE--LIPTPSGLCQCSNG-TVKCDELATPSAVHICPE 786
                 CVPI  C C++ G+ Y+P +  LI      C C  G  V C E       H C  
Sbjct: 2777 G--QACVPIQQCGCYHNGAYYEPEQTVLIDNCRQQCTCHVGKVVVCQE-------HSCKP 2827

Query: 787  GKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAP-GVCR-RGMFNC 844
            G+    C+      P+GG+             +C    PC  G  C P   C+ +G    
Sbjct: 2828 GQV---CQ------PSGGI------------LSCVNKDPC-HGVTCRPQETCKEQGGQGV 2865

Query: 845  TYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFL-------IKSADDSDISVIAQNKKC 897
                  A C ++GD HY+SFDG ++D+   C   L       + +   +  +V  +N+  
Sbjct: 2866 CLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNR 2925

Query: 898  FDNDIVCSKSVLISVGDTEIYLN-DTPYKQKQSGFF-------LENKSTYQLWKAGYYIV 949
             +  +   + V ++   T I ++ D   K + +G          + + +     +   +V
Sbjct: 2926 GNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLV 2985

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
              F    + + +D    + + +   +   + GLCGN D+  +ND    N     +  ++G
Sbjct: 2986 ADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWG 3042

Query: 1010 DSW--------ALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSF 1061
             SW           +C     T       Q + P      +      F +C   +   SF
Sbjct: 3043 GSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESF 3102

Query: 1062 AKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
             K C  D C    GGD + LC ++A+Y   C   G+ I  WR+   C + C
Sbjct: 3103 FKGCVLDVCMG--GGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 3151



 Score =  315 bits (807), Expect = 3e-85
 Identities = 297/1191 (24%), Positives = 470/1191 (39%), Gaps = 156/1191 (13%)

Query: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 3223 FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 3276

Query: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 3277 GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 3335

Query: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181
               N        +  +++ +G+ +TLP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 3336 QIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 3395

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240
            + L++   + G  CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 3396 VRLRVPAAYAGSLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 3447

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 3448 PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 3505

Query: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356
              C A   Y  AC  AG  +++WR  DF  C  +C     +  C   CP +C       G
Sbjct: 3506 GLCPAVATYVAACQAAGAQLREWRRPDF--CPFQCPAHSHYELCGDSCPGSCPSLSAPEG 3563

Query: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQE--CTE-CVC-VGGV 412
                C +GC C  G V+   TC+ +  C C      Y +G        C   C C  GG 
Sbjct: 3564 CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGE 3623

Query: 413  WNCTEQDC-------------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK- 452
             +C    C                      C   GD H+TTFDG  + F+G C Y+L + 
Sbjct: 3624 VSCEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGHRFDFMGTCVYVLAQT 3683

Query: 453  -GT--GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFN 509
             GT  G  +F + LQ+     N G V +  +  +   +F  ++   +    +   +    
Sbjct: 3684 CGTRPGLHRFAV-LQENVAWGN-GRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLP 3741

Query: 510  L---NGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLCGTFNG 564
            +   NG +      S  ++++T FGL++ + +     Y+++T    + +   GLCG +NG
Sbjct: 3742 VVLANGQIRASQHGS-DVVIETDFGLRVAYDL---VYYVRVTVPGNYYQLMCGLCGNYNG 3797

Query: 565  NIRDDFLSPSGMIEGTPQLHANAWR---VSSTCFAPVHVP-------VVDPCNIN-QQNI 613
            + +DDF  P+G   G      N+W      S C  P   P         D C    ++  
Sbjct: 3798 DPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCPPGSAGCIPSDKCPPELEKKY 3857

Query: 614  GYAAHCDVIHQEL--FAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQH 669
                 C ++       + CH  + P    + C  D C  G   S LC+ +  Y   C   
Sbjct: 3858 QKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAA 3917

Query: 670  GVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYE 729
            G  ++     +FC + C +   Y  C+  C   C +LS+P QC D CAEGC C  G  Y 
Sbjct: 3918 GGHVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQCDSGFLYN 3977

Query: 730  DTLNFCVPIFHCRCHYRGSVYQPGE--LIPTPSGLCQCSNG-TVKCDELATPSAVHICPE 786
                 CVPI  C C++ G  Y+P +  LI      C C  G  V C E       H C  
Sbjct: 3978 G--QACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHVGKVVVCQE-------HSCKP 4028

Query: 787  GKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAP-GVCR-RGMFNC 844
            G+    C+      P+GG+             +C    PC  G  C P   C+ +G    
Sbjct: 4029 GQV---CQ------PSGGI------------LSCVTKDPC-HGVTCRPQETCKEQGGQGV 4066

Query: 845  TYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFL-------IKSADDSDISVIAQNKKC 897
                  A C ++GD HY+SFDG ++D+   C   L       + +   +  +V  +N+  
Sbjct: 4067 CLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNR 4126

Query: 898  FDNDIVCSKSVLISVGDTEIYLN-DTPYKQKQSGFF-------LENKSTYQLWKAGYYIV 949
             +  +   + V ++   T I ++ D   K + +G          + + +     +   +V
Sbjct: 4127 GNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLV 4186

Query: 950  VYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFG 1009
              F    + + +D    + + +   +   + GLCGN D+  +ND    N     +  ++G
Sbjct: 4187 ADF---GLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWG 4243

Query: 1010 DSW--------ALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSF 1061
             SW           +C     T       Q + P      S      F +C   +   SF
Sbjct: 4244 GSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLSSGTGGPFTTCHAHVPPESF 4303

Query: 1062 AKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
             K C  D C    GGD + LC ++A+Y   C   G+ I  WR+   C + C
Sbjct: 4304 FKGCVLDVCMG--GGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 4352



 Score =  315 bits (806), Expect = 4e-85
 Identities = 302/1180 (25%), Positives = 469/1180 (39%), Gaps = 188/1180 (15%)

Query: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 1646 HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 1696

Query: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 1697 YVLATTGCPGVSTQGLTPFTVTTKNQNR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 1754

Query: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 1755 RVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 1814

Query: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEA 257
            CGN +   ++D +         I ++  SW     D           P      +  +E 
Sbjct: 1815 CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 1874

Query: 258  IFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHA 313
              F C  L      PF +CH ++ P  +   CV D+C    D +  C+A   Y  AC  A
Sbjct: 1875 PGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAA 1933

Query: 314  GYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQCLGSNLHCLDGCYC 367
            G  I+DWR     C   C ++  +  C S CP +C      T    C G    C++GC C
Sbjct: 1934 GVVIEDWRAQV-GCEITCPENSHYEVCGSPCPASCPSPAPLTTPAVCEGP---CVEGCQC 1989

Query: 368  PDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV--GGVWNCTEQDC- 420
              G V+    C+ L N C C  +G  +  GS+   +  C++ C C   GG   CT   C 
Sbjct: 1990 DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCG 2049

Query: 421  ----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT-----GK 456
                            PV   +C   GD H+ T DG  ++F G C+Y+L         G 
Sbjct: 2050 LGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGA 2109

Query: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR--------GGQILTSPNQGF 508
            + FT+T+       +  +   +S+TL +   +N  +TL           G  +T P   F
Sbjct: 2110 ENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQVDGVFVTLP---F 2162

Query: 509  NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRRTLGLCGTFNGNIR 567
             L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+     GLCG +N +  
Sbjct: 2163 QLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAGSLCGLCGNYNQDPA 2219

Query: 568  DDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ-NIGYAAHCDVIHQ 624
            DD  +  G   G        W+V     C   V  P   PC   QQ + G    C VI  
Sbjct: 2220 DDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISA 2271

Query: 625  E--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPIDFRTQIS 680
                 APCH  + P  Y+Q C  DAC+       LC A+A Y   C   G  +    +  
Sbjct: 2272 TDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPD 2331

Query: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740
            FC   C     Y  C   C  SC SLS+PE C   C EGC C  G  +  + + CVP+  
Sbjct: 2332 FCPFQCPAHSHYELCGDSCPGSCPSLSAPEGCESACREGCVCDAG--FVLSGDTCVPVGQ 2389

Query: 741  CRCHYRGSVYQPGELI---PTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPD 797
            C C +    Y  G+     P    LC+C  G                             
Sbjct: 2390 CGCLHDDRYYPLGQTFYPGPGCDSLCRCREG----------------------------- 2420

Query: 798  PELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYG 857
                 G V+CE   ++   + TC PS   + GCV                     C   G
Sbjct: 2421 -----GEVSCEP--SSCGPHETCRPSGGSL-GCVAVGS---------------TTCQASG 2457

Query: 858  DRHYYSFDGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVG 913
            D HY +FDG  +D++  C   L ++          +V+ +N    +  +  ++ + + V 
Sbjct: 2458 DPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVA 2517

Query: 914  DTEIYLNDTPYKQKQSGFFLE-----NKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIH 968
            +  + L    +K   +G  ++          +  + G  +V+   +  + + +D    + 
Sbjct: 2518 NFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIE-TDFGLRVAYDLVYYVR 2576

Query: 969  IKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCES---PDETIK 1025
            + V   +   + GLCGN++    +D    N  +  NA  FG+SW     +S   P  T  
Sbjct: 2577 VTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCP 2636

Query: 1026 P----------CEAHQNKFPYAKKE-CSILYSDI--FASCRNVIDVTSFAKNCHEDTCNC 1072
            P          C     K  Y K+E C +L S     +SC  ++D     K+C  D C  
Sbjct: 2637 PGSEGCIPSEECPPELEK-KYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLG 2695

Query: 1073 NLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
              GG+   LC++I AY   C   G  +  WR+ T C ++C
Sbjct: 2696 --GGNLSILCSNIHAYVSACQAAGGQVEPWRNETFCPMEC 2733



 Score =  313 bits (803), Expect = 9e-85
 Identities = 307/1194 (25%), Positives = 474/1194 (39%), Gaps = 192/1194 (16%)

Query: 18   PSGSCPYECLN-----GAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHF 72
            PSG     C+N     G  C    TC  Q     G +   +PN     +  C  WG  H+
Sbjct: 2833 PSGGI-LSCVNKDPCHGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHY 2882

Query: 73   ETFDGIYYYFPGNCSYIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFS 127
             +FDG  + F G C+Y+ A   C  +  +    +TV   N  +  G+    Y  +    +
Sbjct: 2883 HSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNR--GNPAVSYVRVVTVAA 2940

Query: 128  NQEEIRIYGHEIKK---NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGI 182
                I I+  EI K   NG+   LP ++  G+I + + A   L+   FG  +++D    +
Sbjct: 2941 LGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRV 3000

Query: 183  YLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPS 242
             + L   + G  CGLCGN +   ++D +         I ++  SW     D         
Sbjct: 3001 DVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRG 3060

Query: 243  DFPNPCSSGMPAFEAIFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ET 298
              P      +  +E   F C  L      PF +CH ++ P  +   CV D+C    D + 
Sbjct: 3061 SCPTCPEDRLEQYEGPGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDI 3119

Query: 299  YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEK 352
             C+A   Y  AC  AG  I+DWR     C   C ++  +  C   CP +C      T   
Sbjct: 3120 LCKALASYVAACQAAGVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPA 3178

Query: 353  QCLGSNLHCLDGCYCPDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVC 408
             C G    C++GC C  G V+    C+ L N C C  +G  +  GS+   +  C++ C C
Sbjct: 3179 VCEGP---CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRC 3235

Query: 409  V--GGVWNCTEQDC-----------------PV---QCSVVGDSHFTTFDGRHYSFIGMC 446
               GG   CT   C                 PV   +C   GD H+ T DG  + F G C
Sbjct: 3236 GPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTC 3295

Query: 447  QYILVKGT-----GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR----- 496
            +Y+L         G + FT+T+       +  +   +S+TL +   +N  +TL       
Sbjct: 3296 EYLLSAPCHGPPLGAENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRK 3351

Query: 497  ---GGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWK 552
                G  +T P   F L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+ 
Sbjct: 3352 LQVDGVFVTLP---FQLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYA 3405

Query: 553  RRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQ 610
                GLCG +N +  DD  +  G   G        W+V     C   V  P   PC   Q
Sbjct: 3406 GSLCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQ 3457

Query: 611  Q-NIGYAAHCDVIHQE--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYL 665
            Q + G    C VI       APCH  + P  Y+Q C  DAC+       LC A+A Y   
Sbjct: 3458 QESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAA 3517

Query: 666  CGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEG 725
            C   G  +    +  FC   C     Y  C   C  SC SLS+PE C   C EGC C  G
Sbjct: 3518 CQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSCPGSCPSLSAPEGCESACREGCVCDAG 3577

Query: 726  KFYEDTLNFCVPIFHCRCHYRGSVYQPGELI---PTPSGLCQCSNGTVKCDELATPSAVH 782
              +  + + CVP+  C C +    Y  G+     P    LC+C  G              
Sbjct: 3578 --FVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREG-------------- 3621

Query: 783  ICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMF 842
                                G V+CE   ++   + TC PS   + GCV           
Sbjct: 3622 --------------------GEVSCEP--SSCGPHETCRPSGGSL-GCVAVGS------- 3651

Query: 843  NCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCF 898
                      C   GD HY +FDG  +D++  C   L ++          +V+ +N    
Sbjct: 3652 --------TTCQASGDPHYTTFDGHRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWG 3703

Query: 899  DNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLE-----NKSTYQLWKAGYYIVVYFP 953
            +  +  ++ + + V +  + L    +K   +G  ++          +  + G  +V+   
Sbjct: 3704 NGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIE-T 3762

Query: 954  EKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWA 1013
            +  + + +D    + + V   +   + GLCGN++    +D    N  +  NA  FG+SW 
Sbjct: 3763 DFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWE 3822

Query: 1014 LGQCES---PDETIKPCEA---HQNKFP------YAKKE-CSILYSDI--FASCRNVIDV 1058
                +S   P  T  P  A     +K P      Y K+E C +L S     +SC  ++D 
Sbjct: 3823 EVVPDSPCLPPPTCPPGSAGCIPSDKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDP 3882

Query: 1059 TSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
                K+C  D C    GG+   LC++I AY   C   G  +  WR+ T C ++C
Sbjct: 3883 QGPLKDCIFDLCLG--GGNLSILCSNIHAYVSACQAAGGHVEPWRNETFCPMEC 3934



 Score =  307 bits (787), Expect = 7e-83
 Identities = 308/1190 (25%), Positives = 459/1190 (38%), Gaps = 222/1190 (18%)

Query: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 4048 HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 4098

Query: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 4099 YVLATTGCPGVSTQGLTPFTVTTKNQNR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 4156

Query: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 4157 RVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 4216

Query: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-------KCVLTPSD------- 243
            CGN +   ++D +         I ++  SW     D          C   P D       
Sbjct: 4217 CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 4276

Query: 244  --FPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYC 300
              F  P SSG                 PF +CH ++ P  +   CV D+C    D +  C
Sbjct: 4277 PGFCGPLSSGTGG--------------PFTTCHAHVPPESFFKGCVLDVCMGGGDRDILC 4322

Query: 301  RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQC 354
            +A   Y  AC  AG  I+DWR     C   C ++  +  C   CP +C      T    C
Sbjct: 4323 KALASYVAACQAAGVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVC 4381

Query: 355  LGSNLHCLDGCYCPDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV- 409
             G    C++GC C  G V+    C+ L N C C  +G  +  GS+   +  C++ C C  
Sbjct: 4382 EGP---CVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGP 4438

Query: 410  -GGVWNCTEQDC-----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQY 448
             GG   CT   C                 PV   +C   GD H+ T DG  + F G C+Y
Sbjct: 4439 GGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEY 4498

Query: 449  ILVKGT-----GKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR------- 496
            +L         G + FT+T+       +  +   +S+TL +   +N  +TL         
Sbjct: 4499 LLSAPCHGPPLGAENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQ 4554

Query: 497  -GGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRR 554
              G  +  P   F L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+   
Sbjct: 4555 VDGVFVALP---FQLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAAS 4608

Query: 555  TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ- 611
              GLCG +N +  DD  +  G   G        W+V     C   V  P   PC   QQ 
Sbjct: 4609 LCGLCGNYNQDPADDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQE 4660

Query: 612  NIGYAAHCDVIHQE--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCG 667
            + G    C VI       APCH  + P  Y+Q C  DAC+       LC A+A Y   C 
Sbjct: 4661 SFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQ 4720

Query: 668  QHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKF 727
              G  +    +  FC + C     Y  C   C  SC SLS+PE C   C EGC C  G  
Sbjct: 4721 AAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG-- 4778

Query: 728  YEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEG 787
            +  + + CVP+  C C + G  Y  GE+                                
Sbjct: 4779 FVLSGDTCVPVGQCGCLHDGRYYPLGEVF------------------------------- 4807

Query: 788  KEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RGMF 842
                   +P PE       CE  C        C P     C  G  C P   CR   G+ 
Sbjct: 4808 -------YPGPE-------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDGVQ 4846

Query: 843  NCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKKCF 898
             C    C   C   G  HY + DG  YD    C   L +       D D S++ +     
Sbjct: 4847 ACHATGC-GRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAG 4905

Query: 899  DND--IVCSKSVLISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIVVY 951
            D    +V     ++S+   +    D      P    +     E ++           +V 
Sbjct: 4906 DLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------MVL 4954

Query: 952  FPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDS 1011
               K + +L+D    + + +   ++ +L GLCGNF+   S+D    N     +   FG +
Sbjct: 4955 QTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAA 5014

Query: 1012 W-ALGQCESPDETIKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTSFA 1062
            W A G  +   E   P     C A +   PY   E C  L +    FA+C+ V+  + + 
Sbjct: 5015 WRAPGSSKGCGEGCGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSEYF 5073

Query: 1063 KNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
            + C  D C     GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 5074 RQCVYDLCAQK--GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 5121



 Score =  306 bits (783), Expect = 2e-82
 Identities = 293/1182 (24%), Positives = 468/1182 (39%), Gaps = 143/1182 (12%)

Query: 22   CPYECL-NGAFCSKTGTCDCQIFQALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDG 77
            C   C  NGA  +   TC  +     G RC +   +      R G C+  G  H+ +FDG
Sbjct: 820  CQRRCTCNGA--THQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGTCQGSGDPHYVSFDG 877

Query: 78   IYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRI- 134
              + F G C+Y+    CG     P + V V N  +  GS    Y       +   ++ + 
Sbjct: 878  RRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHR--GSQTVSYTRAVRVEARGVKVAVR 935

Query: 135  --YGHEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDH 190
              Y  ++  + +   LP     GQ+ + +     +V+T FG ++ +D  + +  K+   +
Sbjct: 936  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDWNARVTAKVPSSY 995

Query: 191  KGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT-PSDFPNPCS 249
                CGLCGN+N   +DD  +       +   F NSW  +T     C  T P D P   S
Sbjct: 996  AEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPG--CGATEPGDCPKLDS 1053

Query: 250  SGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEY 306
                  ++   +C IL   + PF  CH  +DP   +  CV D C         C A   Y
Sbjct: 1054 LVAQQLQS-KNECGILADPKGPFRECHSKLDPQGAVRDCVYDRCLLPGQSGPLCDALATY 1112

Query: 307  ARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCY 366
            A AC  AG  +  WR +   C   C     +  C   CP +C       G    C +GC 
Sbjct: 1113 AAACQAAGATVHPWRSE-ELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCV 1171

Query: 367  CPDGLVMDNGTCISLENCPCGFHGLAYSVGSKI--EQECTE-CVC-VGGVWNCTEQDC-- 420
            C +G  +   +C+ L +C C   G  +  G        C   C C  GG+ +C    C  
Sbjct: 1172 CDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGLVSCESSSCGP 1231

Query: 421  -----------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK--GT--GKDKF 459
                                C   GD H+TTFDGR + F+G C Y+L +  GT  G  +F
Sbjct: 1232 HEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRF 1291

Query: 460  TITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNL---NGIVEI 516
             + LQ+     N G V +  +  +   +F  ++   +    +   +    +   NG +  
Sbjct: 1292 AV-LQENVAWGN-GRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRA 1349

Query: 517  QTLSSLFILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLCGTFNGNIRDDFLSPS 574
                S  ++++T FGL++ + +     Y+++T    + ++  GLCG +NG+ +DDF  P+
Sbjct: 1350 SQHGS-DVVIETDFGLRVAYDL---VYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPN 1405

Query: 575  GMIEGTPQLHANAWR---VSSTCFAPVHVPVVDPCNIN--------QQNIGYAAHCDVIH 623
            G   G      N+W      S C  P   P      I         ++       C ++ 
Sbjct: 1406 GSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLS 1465

Query: 624  QEL--FAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPID-FRTQ 678
                  + CH  + P    + C  D C  G   S LC+ +  Y   C   G  ++ +RT+
Sbjct: 1466 SPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTE 1525

Query: 679  ISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPI 738
             +FC + C     Y  C+  C   C +LS+P QC D CAEGC C  G  Y      CVPI
Sbjct: 1526 -TFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNG--QACVPI 1582

Query: 739  FHCRCHYRGSVYQPGE--LIPTPSGLCQCSNGT-VKCDELATPSAVHICPEGKEYFDCRF 795
              C C++ G  Y+P +  LI      C C  G  + C E       H C  G+    C+ 
Sbjct: 1583 QQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKGMVCQE-------HSCKPGQV---CQ- 1631

Query: 796  PDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAP-GVCR-RGMFNCTYYPCPAVC 853
                 P+GG+             +C    PC  G  C P   C+ +G          A C
Sbjct: 1632 -----PSGGI------------LSCVTKDPC-HGVTCRPQETCKEQGGQGVCLPNYEATC 1673

Query: 854  TIYGDRHYYSFDGLEYDYISDCQVFL-------IKSADDSDISVIAQNKKCFDNDIVCSK 906
             ++GD HY+SFDG ++D+   C   L       + +   +  +V  +N+   +  +   +
Sbjct: 1674 WLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVR 1733

Query: 907  SVLISVGDTEIYLN-DTPYKQKQSGFF-------LENKSTYQLWKAGYYIVVYFPEKDIT 958
             V ++   T I ++ D   K + +G          + + +     +   +V  F    + 
Sbjct: 1734 VVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADF---GLQ 1790

Query: 959  ILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW------ 1012
            + +D    + + +   +   + GLCGN D+  +ND    N     +  ++G SW      
Sbjct: 1791 VSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWD 1850

Query: 1013 --ALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTC 1070
                 +C     T       Q + P      +      F +C   +   SF K C  D C
Sbjct: 1851 PLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVC 1910

Query: 1071 NCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
                GGD + LC ++A+Y   C   G+ I  WR+   C + C
Sbjct: 1911 MG--GGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITC 1950



 Score =  254 bits (648), Expect = 9e-67
 Identities = 226/841 (26%), Positives = 342/841 (40%), Gaps = 99/841 (11%)

Query: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 4424 FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 4477

Query: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 4478 GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 4536

Query: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 4537 QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 4596

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 4597 VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 4648

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 4649 PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 4706

Query: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 4707 GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 4764

Query: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 4765 CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 4824

Query: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 4825 VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 4883

Query: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 4884 QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 4933

Query: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 4934 VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 4990

Query: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619
            GN  DDF+ P+G    + +    AWR   SS        P   P  + ++   Y ++  C
Sbjct: 4991 GNWSDDFVLPNGSAASSVETFGAAWRAPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 5050

Query: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 5051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 5110

Query: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 5111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 5168

Query: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 5169 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 5227

Query: 793  C 793
            C
Sbjct: 5228 C 5228



 Score =  201 bits (512), Expect = 5e-51
 Identities = 195/769 (25%), Positives = 303/769 (39%), Gaps = 120/769 (15%)

Query: 406  CVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQK 465
            C  VGG   C  +   V C   GD H+TTFDGR Y  +G C Y +V+   +D        
Sbjct: 455  CQVVGGKAGCVAESTAV-CRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSV 513

Query: 466  APCEQNLGLVCLQSITLILEDDFNKQVTLGRG--GQILTSPNQGFNLNGIVEIQTL---- 519
                ++ G   +  + L+    ++  V+L RG  G +L   NQ   L   +    L    
Sbjct: 514  EAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVD-NQRSRLPVSLSEGRLRVYQ 572

Query: 520  SSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG 579
            S    +++  FGL + +  D + + + L + ++ +  GLCG +NG+  DDFL+P G +  
Sbjct: 573  SGPRAVVELVFGLVVTYDWDCQ-LALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 631

Query: 580  TPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNI--GYAAH------CDVIHQ--ELFAP 629
                 A++W++    +        D C  N      G A H      C ++ +    FA 
Sbjct: 632  DAVEFASSWKLDDGDYL-----CEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAV 686

Query: 630  CHIYISPGLYYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVVC 686
            CH  + P  + + C +D C  G     LC  L+ YA  C + G+ + D+R+  + C + C
Sbjct: 687  CHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPAN-CPLSC 745

Query: 687  QKGMLYHHCSSFCLHSCISLSSPEQCSD-DCAEGCNCPEGKFYEDTLNFCVPIFHCRCHY 745
                 Y  C   C  SC   ++P  CS   C EGC C  G  +  +   CVP   C C +
Sbjct: 746  PANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPG--FVASGGACVPASSCGCTF 803

Query: 746  RGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGV 805
            +G    PG+               V  DEL                              
Sbjct: 804  QGLQLAPGQ--------------EVWADELCQRRC------------------------- 824

Query: 806  NCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCP-AVCTIYGDRHYYSF 864
                TC       TC     C +G  C+    + G+  C  YP     C   GD HY SF
Sbjct: 825  ----TCNGATHQVTCRDKQSCPAGERCS---VQNGLLGC--YPDRFGTCQGSGDPHYVSF 875

Query: 865  DGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLN 920
            DG  +D++  C   L+ S   +       V+ +N+      +  +++V +     ++ + 
Sbjct: 876  DGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVR 935

Query: 921  DTPYKQK------QSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQ 974
                 Q       Q   F       Q+++ G   VV   +  +T+ +D    +  KV   
Sbjct: 936  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVR-TDFGLTVTYDWNARVTAKVPSS 994

Query: 975  WKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW-----------ALGQCESPDET 1023
            +   L GLCGNF+   ++D+      +  NA  FG+SW             G C   D  
Sbjct: 995  YAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPGCGATEPGDCPKLDSL 1054

Query: 1024 IKPCEAHQNKFPYAKKECSILY--SDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECL 1081
            +    A Q +   +K EC IL      F  C + +D     ++C  D   C L G    L
Sbjct: 1055 V----AQQLQ---SKNECGILADPKGPFRECHSKLDPQGAVRDCVYD--RCLLPGQSGPL 1105

Query: 1082 CTSIAAYAYKCCQEGISIH-WRSSTVCSLDCEYYNEGLGEGPYMLASYG 1129
            C ++A YA  C   G ++H WRS  +C L C  ++       Y   SYG
Sbjct: 1106 CDALATYAAACQAAGATVHPWRSEELCPLSCPPHSH------YEACSYG 1148



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 97/406 (23%), Positives = 143/406 (35%), Gaps = 47/406 (11%)

Query: 1431 CCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGE--IIVAHIEKCSMNQAP 1488
            C  E    CR     +    TFDG    +    SY +V +  E   + A   +       
Sbjct: 464  CVAESTAVCRAQ--GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRG 521

Query: 1489 SGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVV-------PLPFSSQELSIEDSGS 1541
            S R+S +    + V    H + + R     EV  ++V       P+  S   L +  SG 
Sbjct: 522  SRRVSYVGL--VTVRAYSHSVSLTR----GEVGFVLVDNQRSRLPVSLSEGRLRVYQSGP 575

Query: 1542 MYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITN 1601
              V+    GL++ +        +             GLCG  N DP DD    +G +  +
Sbjct: 576  RAVVELVFGLVVTYDW---DCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAPD 632

Query: 1602 MEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI----------FIPCHD 1651
              +   F  SW+++    +       NC      Q       R+          F  CHD
Sbjct: 633  AVE---FASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAVCHD 689

Query: 1652 KVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGK 1707
             + P  F E+   +           C  LSAY   C +  I +  WR+P  C LSCP   
Sbjct: 690  TLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPANCPLSCPANS 749

Query: 1708 EYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSE 1767
             Y+ C   C   +C       + S     E CVC  G +        C+P   C CT   
Sbjct: 750  RYELCGPACPT-SCNGAAAPSNCSGRPCVEGCVCLPGFV---ASGGACVPASSCGCTFQG 805

Query: 1768 DQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDC-DEEPTPVCER 1812
             Q     E+W    DE    +C  NG+   +   C D++  P  ER
Sbjct: 806  LQLAPGQEVW---ADELCQRRCTCNGATHQV--TCRDKQSCPAGER 846



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 95/389 (24%), Positives = 145/389 (37%), Gaps = 47/389 (12%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 2072 CQAWGDPHYVTLDGHRFNFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 2130

Query: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 2131 SVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 2190

Query: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 2191 G-----DSFVRLRVP-AAYAGSLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 2233

Query: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 2234 VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 2292

Query: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718
             ++      +    C A++ YVA C      + +WR PD+C   CP    Y+ C   C  
Sbjct: 2293 LLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSCPG 2352

Query: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWN 1778
                     G  S    RE CVC  G +L       C+P  +C C   +D+    G+ + 
Sbjct: 2353 SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGCL-HDDRYYPLGQTFY 2406

Query: 1779 GGIDECTLYKCLENGSIIPIEPDCDEEPT 1807
             G    +L +C E G +      C    T
Sbjct: 2407 PGPGCDSLCRCREGGEVSCEPSSCGPHET 2435



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 95/389 (24%), Positives = 145/389 (37%), Gaps = 47/389 (12%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 3273 CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 3331

Query: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 3332 SVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 3391

Query: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 3392 G-----DSFVRLRVP-AAYAGSLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 3434

Query: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 3435 VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 3493

Query: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718
             ++      +    C A++ YVA C      + +WR PD+C   CP    Y+ C   C  
Sbjct: 3494 LLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSCPG 3553

Query: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWN 1778
                     G  S    RE CVC  G +L       C+P  +C C   +D+    G+ + 
Sbjct: 3554 SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGCL-HDDRYYPLGQTFY 3607

Query: 1779 GGIDECTLYKCLENGSIIPIEPDCDEEPT 1807
             G    +L +C E G +      C    T
Sbjct: 3608 PGPGCDSLCRCREGGEVSCEPSSCGPHET 3636



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 100/440 (22%), Positives = 165/440 (37%), Gaps = 73/440 (16%)

Query: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 4818 ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 4877

Query: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 4878 CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 4927

Query: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 4928 TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 4983

Query: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635
              GLCG  N +  DD  + NG+  +++E  G    +W    S     +     C    C 
Sbjct: 4984 --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRAPGS----SKGCGEGCGPQGCP 5034

Query: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 5035 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 5094

Query: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 5095 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 5152

Query: 1737 EDCVCKVGTILHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 5153 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 5206

Query: 1796 IPIEPDCDEEPTPVCEREAE 1815
                  C   P  VCE +AE
Sbjct: 5207 TCQAAGC--PPGRVCEVKAE 5224



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 95/400 (23%), Positives = 146/400 (36%), Gaps = 56/400 (14%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   ++FDG         +Y+LV   G+       +  +     G  +    + +
Sbjct: 864  CQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAV 923

Query: 1501 NVTTPIHKIIVNR-LARKVEVDSIVVPLPFSSQELSIE--DSGSMYVITTPAGLIIKW-- 1555
             V     K+ V R    +V VD ++  LPF + +  ++    G   V+ T  GL + +  
Sbjct: 924  RVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDW 983

Query: 1556 -SHLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIES 1611
             + +T  +          SSY E LCG+C   N DP DDL ++ G    N    G    S
Sbjct: 984  NARVTAKVP---------SSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFG---NS 1031

Query: 1612 WEIEKSFEVTMRRPVRNCTEH-DCSQCIDLLNRRI---------------FIPCHDKVSP 1655
            W+ E        RP    TE  DC +   L+ +++               F  CH K+ P
Sbjct: 1032 WQEET-------RPGCGATEPGDCPKLDSLVAQQLQSKNECGILADPKGPFRECHSKLDP 1084

Query: 1656 EDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQP 1711
            +        +           CDAL+ Y A C      +  WR+ + C LSCP    Y+ 
Sbjct: 1085 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1144

Query: 1712 CVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPR 1771
            C   C   +C +    G        E CVC  G  L       C+P   C C   +    
Sbjct: 1145 CSYGCPL-SCGDLPVPGGCGS-ECHEGCVCDEGFAL---SGESCLPLASCGCV-HQGTYH 1198

Query: 1772 TAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
              G+ +  G    +L  C E G +      C   P   C+
Sbjct: 1199 PPGQTFYPGPGCDSLCHCQEGGLVSCESSSCG--PHEACQ 1236



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 87/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 4474 CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 4532

Query: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 4533 SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 4592

Query: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 4593 G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 4635

Query: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 4636 VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 4694

Query: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 4695 LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 4754

Query: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
                     G  S    RE CVC  G +L       C+P  +C C
Sbjct: 4755 SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 4794



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 90/390 (23%), Positives = 141/390 (36%), Gaps = 56/390 (14%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI--PG-------EII 1475
            Q    +C P +E  C   +  +    +FDG         +Y+L     PG          
Sbjct: 1659 QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFT 1716

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-- 1533
            V    +   N A S  +  +    L     IHK  +     KV V+ ++  LP S  +  
Sbjct: 1717 VTTKNQNRGNPAVS-YVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGR 1771

Query: 1534 LSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDP 1587
            +S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P
Sbjct: 1772 ISVTQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNP 1822

Query: 1588 DDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CI 1638
            ++D    NGT+  +   I ++  SW       +     R     C E    Q      C 
Sbjct: 1823 NNDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCG 1879

Query: 1639 DLL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             L       F  CH  V PE F +   ++           C AL++YVA C    + I+ 
Sbjct: 1880 PLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIED 1939

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPH 1751
            WR    C ++CPE   Y+ C  PC A             C     E C C  G +L    
Sbjct: 1940 WRAQVGCEITCPENSHYEVCGSPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---S 1996

Query: 1752 SAQCIP-EKECACTDSEDQPRTAGEIWNGG 1780
            + +C+P    C C  +        E W  G
Sbjct: 1997 ADRCVPLNNGCGCWANGTYHEAGSEFWADG 2026



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 90/390 (23%), Positives = 142/390 (36%), Gaps = 56/390 (14%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI--PG-------EII 1475
            Q    +C P +E  C   +  +    +FDG         +Y+L     PG          
Sbjct: 4061 QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFT 4118

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-- 1533
            V    +   N A S  +  +    L     IHK  +     KV V+ ++  LP S  +  
Sbjct: 4119 VTTKNQNRGNPAVS-YVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGR 4173

Query: 1534 LSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDP 1587
            +S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P
Sbjct: 4174 ISVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNP 4224

Query: 1588 DDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CI 1638
            ++D    NGT+  +   I ++  SW       +     R     C E    Q      C 
Sbjct: 4225 NNDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCG 4281

Query: 1639 DLLNRR--IFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             L +     F  CH  V PE F +   ++           C AL++YVA C    + I+ 
Sbjct: 4282 PLSSGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIED 4341

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPH 1751
            WR    C ++CPE   Y+ C  PC A             C     E C C  G +L    
Sbjct: 4342 WRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---S 4398

Query: 1752 SAQCIP-EKECACTDSEDQPRTAGEIWNGG 1780
            + +C+P    C C  +        E W  G
Sbjct: 4399 ADRCVPLNNGCGCWANGTYHEAGSEFWADG 4428



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 90/390 (23%), Positives = 141/390 (36%), Gaps = 56/390 (14%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI--PG-------EII 1475
            Q    +C P +E  C   +  +    +FDG         +Y+L     PG          
Sbjct: 2860 QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFT 2917

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-- 1533
            V    +   N A S  +  +    L     IHK  +     KV V+ ++  LP S  +  
Sbjct: 2918 VTTKNQNRGNPAVS-YVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGR 2972

Query: 1534 LSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDP 1587
            +S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P
Sbjct: 2973 ISVTQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNP 3023

Query: 1588 DDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CI 1638
            ++D    NGT+  +   I ++  SW       +     R     C E    Q      C 
Sbjct: 3024 NNDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCG 3080

Query: 1639 DLL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ- 1692
             L       F  CH  V PE F +   ++           C AL++YVA C    + I+ 
Sbjct: 3081 PLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIED 3140

Query: 1693 WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPH 1751
            WR    C ++CPE   Y+ C  PC A             C     E C C  G +L    
Sbjct: 3141 WRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---S 3197

Query: 1752 SAQCIP-EKECACTDSEDQPRTAGEIWNGG 1780
            + +C+P    C C  +        E W  G
Sbjct: 3198 ADRCVPLNNGCGCWANGTYHEAGSEFWADG 3227



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 112/530 (21%), Positives = 177/530 (33%), Gaps = 113/530 (21%)

Query: 1279 WRYEP-CATPC-----FKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDC 1332
            WR E  C   C     ++ CS    L+C  LP   GC   C +  + DE     +    C
Sbjct: 1126 WRSEELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCVCDEGF--ALSGESC 1183

Query: 1333 IPVIPT----EPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYD 1388
            +P+       + T  PP +   P                       G  C     D +  
Sbjct: 1184 LPLASCGCVHQGTYHPPGQTFYP-----------------------GPGC-----DSLCH 1215

Query: 1389 CSQYICLNMEWQLYNWSLNC-PKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSEL 1447
            C +   ++ E      S +C P +   P  G  G         C       C+ S   + 
Sbjct: 1216 CQEGGLVSCE------SSSCGPHEACQPSGGSLG---------CVAVGSSTCQAS--GDP 1258

Query: 1448 SIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIH 1507
               TFDG          Y+L +  G     H           G       + + V     
Sbjct: 1259 HYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANF 1318

Query: 1508 KIIVNRLARKVEVDSIVVPLP--FSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIH 1565
             + + +   KV V+ + + LP   ++ ++     GS  VI T  GL + +       D+ 
Sbjct: 1319 TLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAY-------DLV 1371

Query: 1566 FGFRFNL-SSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVT 1621
            +  R  +  +Y + +CG+C   N DP DD +  NG+   N  + G    SWE     EV 
Sbjct: 1372 YYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGSQAGNANEFG---NSWE-----EVV 1423

Query: 1622 MRRPVRNCT-----EHDC---SQCIDLLNRRI---------------FIPCHDKVSPEDF 1658
               P    T       DC    +C   L ++                   CH  V P+  
Sbjct: 1424 PDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGP 1483

Query: 1659 CEKMWINYTYFW---NYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVR 1714
             +    +        +  C  + AYV+ C      ++ WRT  +C + CP    Y+ C  
Sbjct: 1484 LKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCAD 1543

Query: 1715 PCE-ARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
             C    + L+        C    E C C  G +    +   C+P ++C C
Sbjct: 1544 TCSLGCSALSAPPQCQDGC---AEGCQCDSGFLY---NGQACVPIQQCGC 1587



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 84/422 (19%), Positives = 145/422 (34%), Gaps = 58/422 (13%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +    TFDG          Y+L +  G     H           G       + +
Sbjct: 2453 CQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVI 2512

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLP--FSSQELSIEDSGSMYVITTPAGLIIKWSHL 1558
             V      + + +   KV V+ + + LP   ++ ++     GS  VI T  GL + +   
Sbjct: 2513 TVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAY--- 2569

Query: 1559 TGIIDIHFGFRFNL-SSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEI 1614
                D+ +  R  +  +Y + +CG+C   N DP DD +  NG+   N  + G    SWE 
Sbjct: 2570 ----DLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFG---NSWEE 2622

Query: 1615 EKSFEVTMRRPVRNCTEHDC---SQCIDLLNRRI---------------FIPCHDKVSPE 1656
                   +  P        C    +C   L ++                   CH  V P+
Sbjct: 2623 VVPDSPCLPPPTCPPGSEGCIPSEECPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQ 2682

Query: 1657 DFCEKMWINYTYFW---NYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPC 1712
               +    +        +  C  + AYV+ C      ++ WR   +C + CP+   Y+ C
Sbjct: 2683 GPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGQVEPWRNETFCPMECPQNSHYELC 2742

Query: 1713 VRPCE-ARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPR 1771
               C    + L+        C    E C C  G +    +   C+P ++C C  +     
Sbjct: 2743 ADTCSLGCSALSAPLQCPDGC---AEGCQCDSGFLY---NGQACVPIQQCGCYHNGAYYE 2796

Query: 1772 TAGEIWNGGIDECTLYKCLENGSIIPI-EPDCDEEPTPVCEREAEVVMGIIDKWTCCSKE 1830
                +    ID C        G ++   E  C  +P  VC+    ++       +C +K+
Sbjct: 2797 PEQTVL---IDNCRQQCTCHVGKVVVCQEHSC--KPGQVCQPSGGIL-------SCVNKD 2844

Query: 1831 VC 1832
             C
Sbjct: 2845 PC 2846



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 72/352 (20%), Positives = 123/352 (34%), Gaps = 45/352 (12%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +    TFDG+         Y+L +  G     H           G       + +
Sbjct: 3654 CQASGDPHYTTFDGHRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVI 3713

Query: 1501 NVTTPIHKIIVNRLARKVEVDSIVVPLP--FSSQELSIEDSGSMYVITTPAGLIIKWSHL 1558
             V      + + +   KV V+ + + LP   ++ ++     GS  VI T  GL + +   
Sbjct: 3714 TVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAY--- 3770

Query: 1559 TGIIDIHFGFRFNL-SSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEI 1614
                D+ +  R  +  +Y + +CG+C   N DP DD +  NG+   N  + G    SWE 
Sbjct: 3771 ----DLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFG---NSWEE 3823

Query: 1615 EKSFEVTMRRPVRNCTEHDC---SQCIDLLNRRI---------------FIPCHDKVSPE 1656
                   +  P        C    +C   L ++                   CH  V P+
Sbjct: 3824 VVPDSPCLPPPTCPPGSAGCIPSDKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQ 3883

Query: 1657 DFCEKMWINYTYFW---NYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPC 1712
               +    +        +  C  + AYV+ C      ++ WR   +C + CP+   Y+ C
Sbjct: 3884 GPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRNETFCPMECPQNSHYELC 3943

Query: 1713 VRPCE-ARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
               C    + L+        C    E C C  G +    +   C+P ++C C
Sbjct: 3944 ADTCSLGCSALSAPLQCPDGC---AEGCQCDSGFLY---NGQACVPIQQCGC 3989



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 5193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 5252

Query: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 5253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 5305

Query: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 5306 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 5364

Query: 191  KGKSCGLCGNYNDIQSDDFIILQE 214
             GK CG CGN++  Q++D+   QE
Sbjct: 5365 AGKLCGACGNFDGDQTNDWHDSQE 5388


>gi|239757282 PREDICTED: similar to Fc fragment of IgG binding protein
            [Homo sapiens]
          Length = 1403

 Score =  303 bits (777), Expect = 1e-81
 Identities = 304/1177 (25%), Positives = 458/1177 (38%), Gaps = 196/1177 (16%)

Query: 28   NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87
            +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 48   HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 98

Query: 88   YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141
            Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 99   YVLATTGCLGVSTQGLTPFTVTTKNENR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 156

Query: 142  --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197
              NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 157  RVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 216

Query: 198  CGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEA 257
            CGN +   ++D +         I ++  SW     D           P      +  +E 
Sbjct: 217  CGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEG 276

Query: 258  IFFKCQILLQF---PFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHA 313
              F C  L      PF +CH ++ P  +   CV D+C    D +  C+A   Y  AC  A
Sbjct: 277  PGF-CGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAA 335

Query: 314  GYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC------TFEKQCLGSNLHCLDGCYC 367
            G  I+DWR     C   C ++  +  C   CP +C      T    C G    C++GC C
Sbjct: 336  GVVIEDWRAQV-GCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGP---CVEGCQC 391

Query: 368  PDGLVMDNGTCISLEN-CPCGFHGLAYSVGSKI--EQECTE-CVCV--GGVWNCTEQDC- 420
              G V+    C+ L N C C  +G  +  GS+   +  C++ C C   GG   CT   C 
Sbjct: 392  DAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCG 451

Query: 421  ----------------PV---QCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT-----GK 456
                            PV   +C   GD H+ T DG  + F G C+Y+L         G 
Sbjct: 452  LGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGA 511

Query: 457  DKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR--------GGQILTSPNQGF 508
            + FT+T+       +  +   +S+TL +   +N  +TL           G  +  P   F
Sbjct: 512  ENFTVTVANEH-RGSQAVSYTRSVTLQI---YNHSLTLSARWPRKLQVDGVFVALP---F 564

Query: 509  NLNGIVEIQTLSSLFILLKTTFGLKILFAIDGER-IYIQLTSAWKRRTLGLCGTFNGNIR 567
             L+ ++    LS   +++ TT GL + F  DG+  + +++ +A+     GLCG +N +  
Sbjct: 565  QLDSLLHAH-LSGADVVVTTTSGLSLAF--DGDSFVRLRVPAAYAASLCGLCGNYNQDPA 621

Query: 568  DDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQ-NIGYAAHCDVIHQ 624
            DD  +  G   G        W+V     C   V  P   PC   QQ + G    C VI  
Sbjct: 622  DDLKAVGGKPAG--------WQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISA 673

Query: 625  E--LFAPCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPIDFRTQIS 680
                 APCH  + P  Y+Q C  DAC+       LC A+A Y   C   G  +    +  
Sbjct: 674  TDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPD 733

Query: 681  FCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740
            FC + C     Y  C   C  SC SLS+PE C   C EGC C  G  +  + + CVP+  
Sbjct: 734  FCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAG--FVLSGDTCVPVGQ 791

Query: 741  CRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPEL 800
            C C + G  Y  GE+                                       +P PE 
Sbjct: 792  CGCLHDGRYYPLGEVF--------------------------------------YPGPE- 812

Query: 801  PAGGVNCETTCANLAMNFTCTPSS--PCISGCVCAP-GVCR--RGMFNCTYYPCPAVCTI 855
                  CE  C        C P     C  G  C P   CR   G+  C    C   C  
Sbjct: 813  ------CERRC-------ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGC-GRCLA 858

Query: 856  YGDRHYYSFDGLEYDYISDCQVFLIK----SADDSDISVIAQNKKCFDND--IVCSKSVL 909
             G  HY + DG  YD    C   L +       D D S++ +     D    +V     +
Sbjct: 859  NGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQV 918

Query: 910  ISVGDTEIYLND-----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRK 964
            +S+   +    D      P    +     E ++           +V    K + +L+D  
Sbjct: 919  VSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRN-----------MVLQTTKGLRLLFDGD 967

Query: 965  TTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWAL-GQCESPDET 1023
              + + +   ++ +L GLCGNF+   S+D    N     +   FG +W + G  +   E 
Sbjct: 968  AHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEG 1027

Query: 1024 IKP-----CEAHQNKFPYAKKE-CSILYS--DIFASCRNVIDVTSFAKNCHEDTCNCNLG 1075
              P     C A +   PY   E C  L +    FA+C+ V+  + + + C  D C     
Sbjct: 1028 CGPQGCPVCLAEETA-PYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQK-- 1084

Query: 1076 GDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
            GD   LC S+AAY   C   G+++  WR+ + C L C
Sbjct: 1085 GDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHC 1121



 Score =  255 bits (652), Expect = 3e-67
 Identities = 227/841 (26%), Positives = 343/841 (40%), Gaps = 99/841 (11%)

Query: 16   FSPSGSCPYECL----NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGI----CKTW 67
            F   G+C   C      G+      +C       LG  C ++P+  +G   +    C+ W
Sbjct: 424  FWADGTCSQWCRCGPGGGSLVCTPASC------GLGEVCGLLPSGQHGCQPVSTAECQAW 477

Query: 68   GQYHFETFDGIYYYFPGNCSYIFAKDCGDLE---PRYTVWVHNSPKCLGSVYSCYRSISL 124
            G  H+ T DG  + F G C Y+ +  C         +TV V N  +   +V S  RS++L
Sbjct: 478  GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAV-SYTRSVTL 536

Query: 125  FFSNQEEIRI--YGHEIKKNGISLTLPQTIGQIFIEKLADY-ILVKTTFGFSLAWDGISG 181
               N        +  +++ +G+ + LP  +  +    L+   ++V TT G SLA+DG S 
Sbjct: 537  QIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSF 596

Query: 182  IYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDT-KCVLT 240
            + L++   +    CGLCGNYN   +DD         + +      W V       +CV  
Sbjct: 597  VRLRVPAAYAASLCGLCGNYNQDPADDL--------KAVGGKPAGWQVGGAQGCGECVSK 648

Query: 241  PSDFPNPCSSGMPAFEAIFFKCQIL--LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET 298
            P   P+PC+            C ++     P   CH  + P  Y   C+ D C+      
Sbjct: 649  PC--PSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPG 706

Query: 299  -YCRAATEYARACSHAGYPIQDWR-DDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLG 356
              C A   Y  AC  AG  + +WR  DF  C  +C     +  C   CP +C       G
Sbjct: 707  GLCPAVATYVAACQAAGAQLGEWRRPDF--CPLQCPAHSHYELCGDSCPVSCPSLSAPEG 764

Query: 357  SNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGS------KIEQECT------ 404
                C +GC C  G V+   TC+ +  C C   G  Y +G       + E+ C       
Sbjct: 765  CESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGH 824

Query: 405  -------------ECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILV 451
                         EC    GV  C    C  +C   G  H+ T DGR Y   G C Y+L 
Sbjct: 825  VTCQEGAACGPHEECRLEDGVQACHATGCG-RCLANGGIHYITLDGRVYDLHGSCSYVLA 883

Query: 452  K----GTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG 507
            +      G + F+I L+K           LQ + + +     + V+L +G Q+ T   + 
Sbjct: 884  QVCHPKPGDEDFSIVLEKNAAGD------LQRLLVTVA---GQVVSLAQGQQV-TVDGEA 933

Query: 508  FNLN---GIVEIQTLSSLFILLKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFN 563
              L    G V + T     ++L+TT GL++LF  DG+  + + + S ++ R  GLCG FN
Sbjct: 934  VALPVAVGRVRV-TAEGRNMVLQTTKGLRLLF--DGDAHLLMSIPSPFRGRLCGLCGNFN 990

Query: 564  GNIRDDFLSPSGMIEGTPQLHANAWRV--SSTCFAPVHVPVVDPCNINQQNIGYAAH--C 619
            GN  DDF+ P+G    + +    AWRV  SS        P   P  + ++   Y ++  C
Sbjct: 991  GNWSDDFVLPNGSAASSVETFGAAWRVPGSSKGCGEGCGPQGCPVCLAEETAPYESNEAC 1050

Query: 620  DVIH--QELFAPCHIYISPGLYYQLCRHDAC--KCGSSCLCNALAHYAYLCGQHGVPIDF 675
              +   Q  FA C   +SP  Y++ C +D C  K   + LC +LA Y   C   GV +  
Sbjct: 1051 GQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKP 1110

Query: 676  RTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFC 735
                SFC + C     Y  C+  C  SC +LS    C+  C EGC C +          C
Sbjct: 1111 WRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQ--GVC 1168

Query: 736  VPIFHCRCHYRGSVYQPGELIPTP--SGLCQCSNGT-VKCDELATPSAVHICPEGKEYFD 792
            +P+  C C + G        + T   S  C CS+ + + C     P    +C    E  +
Sbjct: 1169 IPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPG-RVCEVKAEARN 1227

Query: 793  C 793
            C
Sbjct: 1228 C 1228



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 100/440 (22%), Positives = 166/440 (37%), Gaps = 73/440 (16%)

Query: 1416 DCGFRGRPVQVNSDICCPEWECPC-------------RCSMLSELSIITFDGNNAALYSM 1462
            +CG  G         C P  EC               RC     +  IT DG    L+  
Sbjct: 818  ECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGS 877

Query: 1463 ASYILVRI----PGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKV 1518
             SY+L ++    PG+   + +    + +  +G +  L      + T   +++     ++V
Sbjct: 878  CSYVLAQVCHPKPGDEDFSIV----LEKNAAGDLQRL------LVTVAGQVVSLAQGQQV 927

Query: 1519 EVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKW---SHLTGIIDIHFGFRFNLSSY 1575
             VD   V LP +   + +   G   V+ T  GL + +   +HL  ++ I   FR  L   
Sbjct: 928  TVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHL--LMSIPSPFRGRLC-- 983

Query: 1576 TEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS 1635
              GLCG  N +  DD  + NG+  +++E  G    +W +  S     +     C    C 
Sbjct: 984  --GLCGNFNGNWSDDFVLPNGSAASSVETFGA---AWRVPGS----SKGCGEGCGPQGCP 1034

Query: 1636 QCI--------------DLLNRR-IFIPCHDKVSPEDFCEKMWINYTYFWN---YECDAL 1677
             C+               L N +  F  C   +SP ++  +   +         + C +L
Sbjct: 1035 VCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSL 1094

Query: 1678 SAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736
            +AY A C    + ++ WRT  +C L CP    Y  C R C+          G T+     
Sbjct: 1095 AAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTT--RCF 1152

Query: 1737 EDCVCKVGTILHRPHSAQCIPEKECACT-DSEDQPRTAGEIWNGGIDECTLYKCLENGSI 1795
            E C C    +L +     CIP ++C CT +    P  +  + +   + C+   C  +  +
Sbjct: 1153 EGCECDDRFLLSQ---GVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCS---CSSSSGL 1206

Query: 1796 IPIEPDCDEEPTPVCEREAE 1815
                  C   P  VCE +AE
Sbjct: 1207 TCQAAGC--PPGRVCEVKAE 1224



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 87/345 (25%), Positives = 130/345 (37%), Gaps = 46/345 (13%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   +T DG+         Y+L   P        E  ++  A   R S       
Sbjct: 474  CQAWGDPHYVTLDGHRFDFQGTCEYLL-SAPCHGPPLGAENFTVTVANEHRGSQAVSYTR 532

Query: 1501 NVTTPI--HKIIVN-RLARKVEVDSIVVPLPFSSQEL-SIEDSGSMYVITTPAGLIIKWS 1556
            +VT  I  H + ++ R  RK++VD + V LPF    L     SG+  V+TT +GL + + 
Sbjct: 533  SVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFD 592

Query: 1557 HLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWE 1613
                  D     R   ++Y   LCG+C   N+DP DDL+   G               W+
Sbjct: 593  G-----DSFVRLRVP-AAYAASLCGLCGNYNQDPADDLKAVGGKPA-----------GWQ 635

Query: 1614 I---EKSFEVTMRRPVRNCTEH--------DCSQCIDLLNRRIFIPCHDKVSPEDFCEKM 1662
            +   +   E   +     CT          D    I   +  +  PCH  V P  + +  
Sbjct: 636  VGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPL-APCHGLVPPAQYFQGC 694

Query: 1663 WINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKEYQPCVRPCEA 1718
             ++      +    C A++ YVA C      + +WR PD+C L CP    Y+ C   C  
Sbjct: 695  LLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPV 754

Query: 1719 RTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
                     G  S    RE CVC  G +L       C+P  +C C
Sbjct: 755  SCPSLSAPEGCESA--CREGCVCDAGFVL---SGDTCVPVGQCGC 794



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 88/389 (22%), Positives = 139/389 (35%), Gaps = 54/389 (13%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYIL-------VRIPGEIIVA 1477
            Q    +C P +E  C   +  +    +FDG         +Y+L       V   G     
Sbjct: 61   QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCLGVSTQGLTPFT 118

Query: 1478 HIEKCSMNQAPS-GRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE--L 1534
               K      P+   +  +    L     IHK  +     KV V+ ++  LP S  +  +
Sbjct: 119  VTTKNENRGNPAVSYVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGRI 174

Query: 1535 SIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDPD 1588
            S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P+
Sbjct: 175  SVAQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNPN 225

Query: 1589 DDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTM---RRPVRNCTEHDCSQ------CID 1639
            +D    NGT+  +   I ++  SW       +     R     C E    Q      C  
Sbjct: 226  NDQVFPNGTLAPS---IPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGP 282

Query: 1640 LL--NRRIFIPCHDKVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-W 1693
            L       F  CH  V PE F +   ++           C AL++YVA C    + I+ W
Sbjct: 283  LAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDHDILCKALASYVAACQAAGVVIEDW 342

Query: 1694 RTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLN-LREDCVCKVGTILHRPHS 1752
            R    C ++CPE   Y+ C  PC A             C     E C C  G +L    +
Sbjct: 343  RAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVL---SA 399

Query: 1753 AQCIP-EKECACTDSEDQPRTAGEIWNGG 1780
             +C+P    C C  +        E W  G
Sbjct: 400  DRCVPLNNGCGCWANGTYHEAGSEFWADG 428



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 50/204 (24%), Positives = 83/204 (40%), Gaps = 22/204 (10%)

Query: 25   ECLNGAFCSKTGTCDCQIFQAL-GTRCQIIPNMGN--GRDGICKTWGQYHFETFDGIYYY 81
            +C     CS +    CQ      G  C++     N     G+C      +  TFDG    
Sbjct: 1193 DCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGA 1252

Query: 82   FPGNCSYIFAKDCGDLE---PRYTVWV-----HNSPKCLGSVYSCYRSISLFFSNQEEIR 133
                  Y  +  C  L+   P Y V       H   + +G V+       +FF +     
Sbjct: 1253 TTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVH-------IFFQDGMVTL 1305

Query: 134  IYGHEIKKNGISLTLP-QTIGQIFIEKLAD-YILVKTTFGFSLAWDGISG-IYLKLSEDH 190
                 +  NG+ + LP + +  + + +  D  +LV+   G  + W G +G + + +S DH
Sbjct: 1306 TPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQV-WLGANGKVAVIVSNDH 1364

Query: 191  KGKSCGLCGNYNDIQSDDFIILQE 214
             GK CG CGN++  Q++D+   QE
Sbjct: 1365 AGKLCGACGNFDGDQTNDWHDSQE 1388


>gi|134268640 tectorin alpha precursor [Homo sapiens]
          Length = 2155

 Score =  300 bits (768), Expect = 1e-80
 Identities = 280/1119 (25%), Positives = 458/1119 (40%), Gaps = 139/1119 (12%)

Query: 64   CKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCYRS 121
            C  +G+ H+ TFDG  ++F G+C+Y+ A+ C      P ++V   N  +  GS  S  + 
Sbjct: 322  CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHR-RGSAVSWVKE 380

Query: 122  ISLFFSNQEEIRIYGH--EIKKNGISLTLPQT--IGQIFIEKLADYILVKTTFGFSLAWD 177
            +S+  +  + +   G    +K N +  +LP T  +G + I +      V+T FG  + +D
Sbjct: 381  LSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLVTFD 440

Query: 178  GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD---D 234
            G     + +   +   +CGLCGNYN    DDF+         +     SW V   D   D
Sbjct: 441  GQHYASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCD 500

Query: 235  TKCVLTPSDFPNPCSSGMPAFEAIFF---KCQIL--LQFPFLSCHEYIDPYLYIASCVND 289
            + CV       + C+    A EA++F    C  L     P   C   +DP  ++ SCV D
Sbjct: 501  SGCV-------DNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYD 553

Query: 290  LCKTDDDET-YCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRD-CISCCPPT 347
            LC   D+ T  C+A   YA  C   G PI DWR      +     SF H   C S CP T
Sbjct: 554  LCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDT 613

Query: 348  CTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKI--EQECT- 404
            C+           C +GC C  G V+    C+ L  C C F G  Y++G        CT 
Sbjct: 614  CSDLTASRNCATPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTV 673

Query: 405  ECVC-VGGVWNCTEQDC-------------------PVQCSVVGDSHFTTFDGRHYSFIG 444
            +C+C  GG   C  + C                      C +  +    TFDG  Y+F  
Sbjct: 674  QCLCEEGGDVYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPS 733

Query: 445  MCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGR-----GGQ 499
               Y L+K   +    + +     + + G   L+ + +++ D   K   +G       GQ
Sbjct: 734  EFSYTLLKTCPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQ 793

Query: 500  ILTSPNQGFNLNGIVEI-QTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGL 558
             +  P   F+ +G +EI +  +S  +  K   G+  +   D   +YI+L++ +   T GL
Sbjct: 794  EVELP--FFHPSGKLEIYRNKNSTTVESK---GVVTVQYSDIGLLYIRLSTTYFNCTGGL 848

Query: 559  CGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGY--- 615
            CG +N N  D+F  P+G       +   +W             ++  CN + + + +   
Sbjct: 849  CGFYNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRS 908

Query: 616  AAHCDVIH---QELFAPCHIYISPGLYYQLCRHDACKCG--SSCLCNALAHYAYLCGQHG 670
             + C +I+      F  CH  ++   YY+ C    C+ G   S LC+++A YA  C    
Sbjct: 909  RSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNAD 968

Query: 671  VPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYED 730
            V +       FC + C +   +  C + C  +C +L+    C D C+EGC C EG  Y  
Sbjct: 969  VEVGPWRTYDFCPLECPENSHFEECIT-CTETCETLTLGPICVDSCSEGCQCDEG--YAL 1025

Query: 731  TLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEY 790
              + CV    C C++ G                          +LAT     +  + + +
Sbjct: 1026 LGSQCVTRSECGCNFEG-------------------------HQLATNETFWVDLDCQIF 1060

Query: 791  FDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCP 850
              C   D       V+CET          C     C+            G++ C      
Sbjct: 1061 CYCSGTD-----NRVHCET--------IPCKDDEYCME---------EGGLYYC-QARTD 1097

Query: 851  AVCTIYGDRHYYSFDGLEYDYISDCQVFLI----KSADDS--DISVIAQNKKCFDNDIVC 904
            A C + G  HY +FDG  +D+ + C + L     + + DS     V A+N+    +  + 
Sbjct: 1098 ASCIVSGYGHYLTFDGFPFDFQTSCPLILCTTGSRPSSDSFPKFVVTAKNEDRDPSLALW 1157

Query: 905  SKSVLISVGDTEIYLNDTPYKQ----KQSGFFLENK---STYQLWKAGYYIVVYFPEKDI 957
             K V ++V    I ++   YK          +L  K       ++  G+++VV   +  +
Sbjct: 1158 VKQVDVTVFGYSIVIH-RAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVE-TDFGL 1215

Query: 958  TILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQ- 1016
             +++D KT + I V    +N   GLCG ++    +D+     L   +   FG SW     
Sbjct: 1216 KVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFGQSWVKRDT 1275

Query: 1017 -CESPDETIKPCEAHQNKFPYAKKECSIL--YSDIFASCRNVIDVTSFAKNCHEDTCNCN 1073
             C+       P  A    F   ++ CS++   +  F+ C + ++ T F KNC  D+C   
Sbjct: 1276 FCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAAFSKCHSKVNPTFFYKNCLFDSCID- 1334

Query: 1074 LGGDCECLCTSIAAYAYKCCQEGISI-HWRSSTVCSLDC 1111
             GG  +  C+ +  YA  C  +GI++  WR+ T C++ C
Sbjct: 1335 -GGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTC 1372



 Score =  249 bits (635), Expect = 3e-65
 Identities = 272/1184 (22%), Positives = 451/1184 (38%), Gaps = 179/1184 (15%)

Query: 15   FFSPSGSCPYECLNGAFCSKTGTCDC-QIFQALGTRCQIIPNMGN---GRDGICKTWGQY 70
            FF  + +C  +CL    C + G   C       G  C +          R+ +C      
Sbjct: 664  FFWATANCTVQCL----CEEGGDVYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQ 719

Query: 71   HFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFFSNQE 130
               TFDG  Y FP   SY   K C +      + ++      G  +   R + +  ++QE
Sbjct: 720  VLHTFDGASYAFPSEFSYTLLKTCPERPEYLEIDINKKKPDAGPAW--LRGLRILVADQE 777

Query: 131  EIRIYG---HEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLK 185
             ++I G    E+K NG  + LP     G++ I +  +   V++    ++ +  I  +Y++
Sbjct: 778  -VKIGGIGASEVKLNGQEVELPFFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIR 836

Query: 186  LSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFP 245
            LS  +   + GLCG YN   SD+F +     T+++A+F  SW   T  +  C     D  
Sbjct: 837  LSTTYFNCTGGLCGFYNANASDEFCLPNGKCTDNLAVFLESW---TTFEEICNGECGDLL 893

Query: 246  NPCS--SGMPAFEAIFFKCQIL---LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDET-Y 299
              C+  S +  F     +C I+       FL CH  ++   Y  +C+  LC++  +E+  
Sbjct: 894  KACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESEL 953

Query: 300  CRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPP--TCTFEKQCLGS 357
            C +   YA AC +A   +  WR  +  C  +C ++    +CI+C     T T    C+ S
Sbjct: 954  CDSVARYASACKNADVEVGPWRT-YDFCPLECPENSHFEECITCTETCETLTLGPICVDS 1012

Query: 358  NLHCLDGCYCPDGLVMDNGTCISLENCPCGFHG-----------------LAYSVGSKIE 400
               C +GC C +G  +    C++   C C F G                   Y  G+   
Sbjct: 1013 ---CSEGCQCDEGYALLGSQCVTRSECGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNR 1069

Query: 401  QECTECVCV--------GGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVK 452
              C    C         GG++ C  +     C V G  H+ TFDG  + F   C  IL  
Sbjct: 1070 VHCETIPCKDDEYCMEEGGLYYCQART-DASCIVSGYGHYLTFDGFPFDFQTSCPLILCT 1128

Query: 453  GTGKD------KFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQ---ILTS 503
               +       KF +T +    + +L L   Q    +    F   + + R  +   ++ S
Sbjct: 1129 TGSRPSSDSFPKFVVTAKNEDRDPSLALWVKQVDVTV----FGYSIVIHRAYKHTVLVNS 1184

Query: 504  PNQGFNLN-GIVEIQTLSSLF-ILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLC 559
                  L  G  +I   S  F ++++T FGLK+++     + ++ +T   + +  T GLC
Sbjct: 1185 ERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVY---DWKTFLSITVPRSMQNSTYGLC 1241

Query: 560  GTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAH- 618
            G +NGN  DD   P G++  +      +W    T      V   D C    +  G++   
Sbjct: 1242 GRYNGNPDDDLEMPMGLLASSVNEFGQSWVKRDTF---CQVGCGDRCPSCAKVEGFSKVQ 1298

Query: 619  --CDVIHQE--LFAPCHIYISPGLYYQLCRHDACKCGSSC--LCNALAHYAYLCGQHGVP 672
              C +I  +   F+ CH  ++P  +Y+ C  D+C  G +    C+ L +YA  C   G+ 
Sbjct: 1299 QLCSLIPNQNAAFSKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIT 1358

Query: 673  IDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTL 732
            +      + C V C     Y  C S C   C ++     CS  C EGC+C  G  Y    
Sbjct: 1359 VTGWRNYTSCTVTCPPNSHYESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDAG--YVLNG 1416

Query: 733  NFCVPIFHCRCHYRGSVYQPGELI--PTPSGLCQC-SNGTVKCDELATPSAVHICPEGKE 789
              C+    C C+  G  Y+P +L      +  C+C     ++CD          C   +E
Sbjct: 1417 KSCILPHSCGCYSDGKYYEPKQLFWNSDCTRRCRCFRRNVIQCDP-------RQCKSDEE 1469

Query: 790  YFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPC 849
                                                    C    GV  RG F+      
Sbjct: 1470 ----------------------------------------CALRNGV--RGCFSTK---- 1483

Query: 850  PAVCTIYGDRHYYSFDGLEYDYISDCQVFL---IKSADDSDISVIAQNKKCFDNDIVCSK 906
             + C   G   + +FDG    + ++C   L    +   D    +I    K    ++    
Sbjct: 1484 TSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSAPNLTIIS 1543

Query: 907  SVLISVGDTEIYLNDTPYKQKQSGF-----FLENKSTYQLWKAGYYIVVYFPEKDITILW 961
             V   + + +I +ND     K +G      F+   +T      G+ ++   P  DI I +
Sbjct: 1544 PVYFYINEEQILINDR-NTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSP--DIQIYY 1600

Query: 962  DRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPD 1021
            +    I I +  + +NK+ GLCGNF+   ++D  T     V ++ V   SW     +   
Sbjct: 1601 NGFNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQK-- 1658

Query: 1022 ETIKPCEAHQNKFPYAKKECSILY----------------SDIFASCRNVIDVTSFAKNC 1065
              + P   ++ +F      C  ++                   F  C  ++D   F ++C
Sbjct: 1659 RPLAP-SCNELQFSQYAAMCDNVHIQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESC 1717

Query: 1066 HEDTCNCNLGGDCECLCTSIAAYAYKCCQEGI-SIHWRSSTVCS 1108
            + D C  +       LC S+AAY   C   GI S  W     CS
Sbjct: 1718 YLDGCYSHKKFQ---LCGSLAAYGEACRSFGILSTEWIEKENCS 1758



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 73/295 (24%), Positives = 118/295 (40%), Gaps = 29/295 (9%)

Query: 64   CKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEP-------RYTVWVHNSPKCLGSVY 116
            C   G   F TFDG +  FP NC+++ +  C  L          +  W   +   +  VY
Sbjct: 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSAPNLTIISPVY 1546

Query: 117  SCYRSISLFFSNQEEIRIYGHE-IKKNGISLTLPQTIGQIF-IEKLADYILVKTTFGFSL 174
                    F+ N+E+I I     +K NG  + +P   G    I     ++++ T+    +
Sbjct: 1547 --------FYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQI 1598

Query: 175  AWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDD 234
             ++G + I + +SE  + K CGLCGN+N   +DD++ L+        + A SW  +T   
Sbjct: 1599 YYNGFNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSW--KTNGM 1656

Query: 235  TKCVLTPSDFPNPCSSGMPAFEAIFFK-------CQILLQFP--FLSCHEYIDPYLYIAS 285
             K  L PS      S      + +  +       C  L      F  C+  +DP  +  S
Sbjct: 1657 QKRPLAPSCNELQFSQYAAMCDNVHIQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYES 1716

Query: 286  CVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDC 340
            C  D C +      C +   Y  AC   G    +W +    C+   +D  V  DC
Sbjct: 1717 CYLDGCYSHKKFQLCGSLAAYGEACRSFGILSTEWIEK-ENCSGVVEDPCVGADC 1770



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 90/369 (24%), Positives = 152/369 (41%), Gaps = 43/369 (11%)

Query: 1431 CCPEWECPCRCSMLSELSII-TFDGNNAALYSMASYILVRI---PGEIIVAHIEKCSMNQ 1486
            C P+ E  C   +LS+  ++ TFDG + A  S  SY L++      E +   I K   + 
Sbjct: 705  CFPKRETVC---LLSQNQVLHTFDGASYAFPSEFSYTLLKTCPERPEYLEIDINKKKPDA 761

Query: 1487 APSGRISGLCFKKLNVTTPIHKIIVNRL-ARKVEVDSIVVPLPF--SSQELSIEDSGSMY 1543
             P+        + L +     ++ +  + A +V+++   V LPF   S +L I  + +  
Sbjct: 762  GPAW------LRGLRILVADQEVKIGGIGASEVKLNGQEVELPFFHPSGKLEIYRNKNST 815

Query: 1544 VITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNME 1603
             + +   + +++S + G++ I     +   + T GLCG  N +  D+  + NG    N+ 
Sbjct: 816  TVESKGVVTVQYSDI-GLLYIRLSTTY--FNCTGGLCGFYNANASDEFCLPNGKCTDNL- 871

Query: 1604 DIGLFIESW----EIEKSFEVTMRRPVRNCTE-----HDCSQC--IDLLNRRIFIPCHDK 1652
               +F+ESW    EI       + +   N +E        S+C  I+  +   F+ CH  
Sbjct: 872  --AVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGV 929

Query: 1653 VSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGKE 1708
            V+   +              E   CD+++ Y + C   D+ +  WRT D+C L CPE   
Sbjct: 930  VNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSH 989

Query: 1709 YQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSED 1768
            ++ C+   E    L        SC    E C C  G  L     +QC+   EC C     
Sbjct: 990  FEECITCTETCETLTLGPICVDSC---SEGCQCDEGYAL---LGSQCVTRSECGCNFEGH 1043

Query: 1769 QPRTAGEIW 1777
            Q  T    W
Sbjct: 1044 QLATNETFW 1052



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 83/329 (25%), Positives = 134/329 (40%), Gaps = 40/329 (12%)

Query: 805  VNCETTCANLAMN--FTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAV----CTIYGD 858
            +NC   C  L  N    C  +S C    VC P    +G F    + C AV    C ++G+
Sbjct: 277  LNCTVKCRCLDFNNEIYCQEAS-CSPYEVCEP----KGKF----FYCSAVETSTCVVFGE 327

Query: 859  RHYYSFDGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGD 914
             HY++FDG  + +   C   L +    +      SV A+N+    + +   K + + V  
Sbjct: 328  PHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNG 387

Query: 915  TEIYLNDTPYKQKQSGFFLE------NKSTYQLWKAGYYIVVYFPEKDITIL--WDRKTT 966
             +I +    Y + +    +       +  T +++++G    V   E D  +L  +D +  
Sbjct: 388  YKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAV---ETDFGLLVTFDGQHY 444

Query: 967  IHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW----ALGQCESP-D 1021
              I V   + N   GLCGN++K   +D    +     +    G+SW    A  +C+S   
Sbjct: 445  ASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCV 504

Query: 1022 ETIKPCEAHQNKFPYAKKECSIL--YSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCE 1079
            +    C+A      +    C  L         C  V+D T+F  +C  D C+    G   
Sbjct: 505  DNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNG--T 562

Query: 1080 CLCTSIAAYAYKCCQEGISI-HWRSSTVC 1107
             LC +I AYA  C   GI I  WR+ T C
Sbjct: 563  LLCQAIQAYALVCQALGIPIGDWRTQTGC 591



 Score = 75.5 bits (184), Expect = 6e-13
 Identities = 72/306 (23%), Positives = 122/306 (39%), Gaps = 30/306 (9%)

Query: 1495 LCFKKLNVTTPIHKIIVNRLARK---VEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGL 1551
            L  K+++VT   + I+++R  +    V  + + +PL     +++I   G   V+ T  GL
Sbjct: 1156 LWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVETDFGL 1215

Query: 1552 IIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIES 1611
             + +   T +         ++ + T GLCG  N +PDDDL M  G + +++ + G   +S
Sbjct: 1216 KVVYDWKTFL---SITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFG---QS 1269

Query: 1612 WEIEKSF-EVTMRRPVRNCTEHDCSQCIDLL------NRRIFIPCHDKVSPEDFCEKMWI 1664
            W    +F +V       +C + +    +  L          F  CH KV+P  F +    
Sbjct: 1270 WVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAAFSKCHSKVNPTFFYKNCLF 1329

Query: 1665 NYTY---FWNYECDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCEART 1720
            +           C  L  Y + C    I +  WR    C+++CP    Y+ CV  C+ R 
Sbjct: 1330 DSCIDGGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTCPPNSHYESCVSVCQPRC 1389

Query: 1721 CLNQWFYGHTSCLN-LREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNG 1779
               +     + C +   E C C  G +L   +   CI    C C             WN 
Sbjct: 1390 AAIRL---KSDCSHYCVEGCHCDAGYVL---NGKSCILPHSCGCYSDGKYYEPKQLFWN- 1442

Query: 1780 GIDECT 1785
               +CT
Sbjct: 1443 --SDCT 1446



 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 99/431 (22%), Positives = 157/431 (36%), Gaps = 62/431 (14%)

Query: 1416 DCGFRGRPVQVNSDICCPEWECP-------------------CRCSMLSELSIITFDGNN 1456
            +C  + R +  N++I C E  C                      C +  E    TFDG  
Sbjct: 278  NCTVKCRCLDFNNEIYCQEASCSPYEVCEPKGKFFYCSAVETSTCVVFGEPHYHTFDGFL 337

Query: 1457 AALYSMASYILVR--IPGEIIVAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRL 1514
                   +Y+L R  +    +     +          +S +  K+L+V    +KI++ + 
Sbjct: 338  FHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSWV--KELSVEVNGYKILIPKG 395

Query: 1515 AR-KVEVDSIVVPLPFSSQ--ELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFN 1571
            +  +V+V+ +V  LP +     + I  SG    + T  GL++ +         H+     
Sbjct: 396  SYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLVTFDGQ------HYASISV 449

Query: 1572 LSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRN 1628
              SY    CG+C   N++P DD    +G    ++ D+G   ESW +  +        V N
Sbjct: 450  PGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLG---ESWRVYHADWKCDSGCVDN 506

Query: 1629 CTEHDC--------SQCIDLLNRRI--FIPCHDKVSPEDF---CEKMWINYTYFWNYECD 1675
            CT+ D         S     LN+       C   V P  F   C     +        C 
Sbjct: 507  CTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQ 566

Query: 1676 ALSAYVALCNKFDICI-QWRTPDYC--SLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSC 1732
            A+ AY  +C    I I  WRT   C  ++ CP    Y  C   C   TC +       +C
Sbjct: 567  AIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPD-TCSD--LTASRNC 623

Query: 1733 LN-LREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLE 1791
                 E C C  G +L    ++QC+P  +C C D +    T GE +    +      C E
Sbjct: 624  ATPCTEGCECNQGFVLS---TSQCVPLHKCGC-DFDGHYYTMGEFFWATANCTVQCLCEE 679

Query: 1792 NGSIIPIEPDC 1802
             G +      C
Sbjct: 680  GGDVYCFNKTC 690


>gi|239757286 PREDICTED: similar to Fc fragment of IgG binding protein
            [Homo sapiens]
          Length = 1472

 Score =  268 bits (684), Expect = 6e-71
 Identities = 239/953 (25%), Positives = 385/953 (40%), Gaps = 146/953 (15%)

Query: 45   ALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCG--DLEP 99
            A G RCQ++            +C+  G  H+ TFDG  Y   G CSY   + C   D  P
Sbjct: 511  AAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLP 570

Query: 100  RYTVWVHNSPKC--------LGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQT 151
             ++V   N  +         L +V +   S+SL    + E+     + +++ + ++L + 
Sbjct: 571  AFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSL---TRGEVGFVLVDNQRSRLPVSLSE- 626

Query: 152  IGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFII 211
             G++ + +     +V+  FG  + +D    + L L    + + CGLCGNYN   +DDF+ 
Sbjct: 627  -GRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLT 685

Query: 212  LQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFK----CQIL-- 265
                   D   FA+SW +   D     L      N C +  P  +A  ++    C +L  
Sbjct: 686  PDGALAPDAVEFASSWKLDDGD----YLCEDGCQNNCPACTPG-QAQHYEGDRLCGMLTK 740

Query: 266  LQFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEYARACSHAGYPIQDWRDDF 324
            L  PF  CH+ +DP  ++  CV DLC    +  + CR  + YA+AC   G  + DWR   
Sbjct: 741  LDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRS-- 798

Query: 325  PA-CTDKCDDSFVHRDCISCCPPTC---TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCIS 380
            PA C   C  +  +  C   CP +C        C G    C++GC C  G V   G C+ 
Sbjct: 799  PANCPLSCPANSRYELCGPACPTSCNGAAAPSNCSGR--PCVEGCVCLPGFVASGGACVP 856

Query: 381  LENCPCGFHGLAYSVGSKI--EQEC-TECVCVGGVWNCT---EQDCPV--QCSV------ 426
              +C C F GL  + G ++  ++ C   C C G     T   +Q CP   +CSV      
Sbjct: 857  ASSCGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLG 916

Query: 427  -----------VGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLV 475
                        GD H+ +FDGR + F+G C Y+LV   G++      +     ++ G  
Sbjct: 917  CYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQ 976

Query: 476  CLQSITLILEDDFNKQVTLGR--GGQILTS------PNQGFNLNGIVEIQTLSSLFILLK 527
             +     +  +    +V + R   GQ+L        P Q    +G V++        +++
Sbjct: 977  TVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQA--ADGQVQV-FRQGRDAVVR 1033

Query: 528  TTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANA 587
            T FGL + +  +  R+  ++ S++     GLCG FNG+  DD     G          N+
Sbjct: 1034 TDFGLTVTYDWNA-RVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNS 1092

Query: 588  WRVSST--CFA--PVHVPVVDPCNINQQNIGYAAHCDVIHQEL--FAPCHIYISPGLYYQ 641
            W+  +   C A  P   P +D  ++  Q +     C ++      F  CH  + P    +
Sbjct: 1093 WQEETRPGCGATEPGDCPKLD--SLVAQQLQSKNECGILADPKGPFRECHSKLDPQGAVR 1150

Query: 642  LCRHDACKC--GSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFC 699
             C +D C     S  LC+ALA YA  C   G  +        C + C     Y  CS  C
Sbjct: 1151 DCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEACSYGC 1210

Query: 700  LHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELI--- 756
              SC  L  P  C  +C EGC C EG  +  +   C+P+  C C ++G+ + PG+     
Sbjct: 1211 PLSCGDLPVPGGCGSECHEGCVCDEG--FALSGESCLPLASCGCVHQGTYHPPGQTFYPG 1268

Query: 757  PTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAM 816
            P    LC C  G                                  G V+CE+  ++   
Sbjct: 1269 PGCDSLCHCQEG----------------------------------GLVSCES--SSCGP 1292

Query: 817  NFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQ 876
            +  C PS   + GCV                   + C   GD HY +FDG  +D++  C 
Sbjct: 1293 HEACQPSGGSL-GCVAVGS---------------STCQASGDPHYTTFDGRRFDFMGTCV 1336

Query: 877  VFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYK 925
              L ++          +V+ +N    +  +  ++ + + V +  + L    +K
Sbjct: 1337 YVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWK 1389



 Score =  201 bits (512), Expect = 5e-51
 Identities = 195/769 (25%), Positives = 303/769 (39%), Gaps = 120/769 (15%)

Query: 406  CVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQK 465
            C  VGG   C  +   V C   GD H+TTFDGR Y  +G C Y +V+   +D        
Sbjct: 516  CQVVGGKAGCVAESTAV-CRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSV 574

Query: 466  APCEQNLGLVCLQSITLILEDDFNKQVTLGRG--GQILTSPNQGFNLNGIVEIQTL---- 519
                ++ G   +  + L+    ++  V+L RG  G +L   NQ   L   +    L    
Sbjct: 575  EAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVD-NQRSRLPVSLSEGRLRVYQ 633

Query: 520  SSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEG 579
            S    +++  FGL + +  D + + + L + ++ +  GLCG +NG+  DDFL+P G +  
Sbjct: 634  SGPRAVVELVFGLVVTYDWDCQ-LALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 692

Query: 580  TPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNI--GYAAH------CDVIHQ--ELFAP 629
                 A++W++    +        D C  N      G A H      C ++ +    FA 
Sbjct: 693  DAVEFASSWKLDDGDYL-----CEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAV 747

Query: 630  CHIYISPGLYYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAVVC 686
            CH  + P  + + C +D C  G     LC  L+ YA  C + G+ + D+R+  + C + C
Sbjct: 748  CHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPAN-CPLSC 806

Query: 687  QKGMLYHHCSSFCLHSCISLSSPEQCSD-DCAEGCNCPEGKFYEDTLNFCVPIFHCRCHY 745
                 Y  C   C  SC   ++P  CS   C EGC C  G  +  +   CVP   C C +
Sbjct: 807  PANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPG--FVASGGACVPASSCGCTF 864

Query: 746  RGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGV 805
            +G    PG+               V  DEL                              
Sbjct: 865  QGLQLAPGQ--------------EVWADELCQRRC------------------------- 885

Query: 806  NCETTCANLAMNFTCTPSSPCISGCVCAPGVCRRGMFNCTYYPCP-AVCTIYGDRHYYSF 864
                TC       TC     C +G  C+    + G+  C  YP     C   GD HY SF
Sbjct: 886  ----TCNGATHQVTCRDKQSCPAGERCS---VQNGLLGC--YPDRFGTCQGSGDPHYVSF 936

Query: 865  DGLEYDYISDCQVFLIKSADDSD----ISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLN 920
            DG  +D++  C   L+ S   +       V+ +N+      +  +++V +     ++ + 
Sbjct: 937  DGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVR 996

Query: 921  DTPYKQK------QSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQ 974
                 Q       Q   F       Q+++ G   VV   +  +T+ +D    +  KV   
Sbjct: 997  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVR-TDFGLTVTYDWNARVTAKVPSS 1055

Query: 975  WKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW-----------ALGQCESPDET 1023
            +   L GLCGNF+   ++D+      +  NA  FG+SW             G C   D  
Sbjct: 1056 YAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPGCGATEPGDCPKLDSL 1115

Query: 1024 IKPCEAHQNKFPYAKKECSILY--SDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECL 1081
            +    A Q +   +K EC IL      F  C + +D     ++C  D   C L G    L
Sbjct: 1116 V----AQQLQ---SKNECGILADPKGPFRECHSKLDPQGAVRDCVYD--RCLLPGQSGPL 1166

Query: 1082 CTSIAAYAYKCCQEGISIH-WRSSTVCSLDCEYYNEGLGEGPYMLASYG 1129
            C ++A YA  C   G ++H WRS  +C L C  ++       Y   SYG
Sbjct: 1167 CDALATYAAACQAAGATVHPWRSEELCPLSCPPHSH------YEACSYG 1209



 Score =  153 bits (386), Expect = 2e-36
 Identities = 126/472 (26%), Positives = 187/472 (39%), Gaps = 46/472 (9%)

Query: 22   CPYECL-NGAFCSKTGTCDCQIFQALGTRCQIIPNMGN---GRDGICKTWGQYHFETFDG 77
            C   C  NGA  +   TC  +     G RC +   +      R G C+  G  H+ +FDG
Sbjct: 881  CQRRCTCNGA--THQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGTCQGSGDPHYVSFDG 938

Query: 78   IYYYFPGNCSYIFAKDCGDLE--PRYTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRI- 134
              + F G C+Y+    CG     P + V V N  +  GS    Y       +   ++ + 
Sbjct: 939  RRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHR--GSQTVSYTRAVRVEARGVKVAVR 996

Query: 135  --YGHEIKKNGISLTLP--QTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDH 190
              Y  ++  + +   LP     GQ+ + +     +V+T FG ++ +D  + +  K+   +
Sbjct: 997  REYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDWNARVTAKVPSSY 1056

Query: 191  KGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLT-PSDFPNPCS 249
                CGLCGN+N   +DD  +       +   F NSW  +T     C  T P D P   S
Sbjct: 1057 AEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPG--CGATEPGDCPKLDS 1114

Query: 250  SGMPAFEAIFFKCQILL--QFPFLSCHEYIDPYLYIASCVNDLCKTDDDE-TYCRAATEY 306
                  ++   +C IL   + PF  CH  +DP   +  CV D C         C A   Y
Sbjct: 1115 LVAQQLQS-KNECGILADPKGPFRECHSKLDPQGAVRDCVYDRCLLPGQSGPLCDALATY 1173

Query: 307  ARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCY 366
            A AC  AG  +  WR +   C   C     +  C   CP +C       G    C +GC 
Sbjct: 1174 AAACQAAGATVHPWRSE-ELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCV 1232

Query: 367  CPDGLVMDNGTCISLENCPCGFHGLAYSVGSKI--EQECTE-CVC-VGGVWNCTEQDC-- 420
            C +G  +   +C+ L +C C   G  +  G        C   C C  GG+ +C    C  
Sbjct: 1233 CDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGLVSCESSSCGP 1292

Query: 421  -----------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTG 455
                                C   GD H+TTFDGR + F+G C Y+L +  G
Sbjct: 1293 HEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCG 1344



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 97/406 (23%), Positives = 143/406 (35%), Gaps = 47/406 (11%)

Query: 1431 CCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGE--IIVAHIEKCSMNQAP 1488
            C  E    CR     +    TFDG    +    SY +V +  E   + A   +       
Sbjct: 525  CVAESTAVCRAQ--GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRG 582

Query: 1489 SGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVV-------PLPFSSQELSIEDSGS 1541
            S R+S +    + V    H + + R     EV  ++V       P+  S   L +  SG 
Sbjct: 583  SRRVSYVGL--VTVRAYSHSVSLTR----GEVGFVLVDNQRSRLPVSLSEGRLRVYQSGP 636

Query: 1542 MYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITN 1601
              V+    GL++ +        +             GLCG  N DP DD    +G +  +
Sbjct: 637  RAVVELVFGLVVTYDW---DCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAPD 693

Query: 1602 MEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI----------FIPCHD 1651
              +   F  SW+++    +       NC      Q       R+          F  CHD
Sbjct: 694  AVE---FASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAVCHD 750

Query: 1652 KVSPEDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICI-QWRTPDYCSLSCPEGK 1707
             + P  F E+   +           C  LSAY   C +  I +  WR+P  C LSCP   
Sbjct: 751  TLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPANCPLSCPANS 810

Query: 1708 EYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSE 1767
             Y+ C   C   +C       + S     E CVC  G +        C+P   C CT   
Sbjct: 811  RYELCGPACPT-SCNGAAAPSNCSGRPCVEGCVCLPGFV---ASGGACVPASSCGCTFQG 866

Query: 1768 DQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDC-DEEPTPVCER 1812
             Q     E+W    DE    +C  NG+   +   C D++  P  ER
Sbjct: 867  LQLAPGQEVW---ADELCQRRCTCNGATHQV--TCRDKQSCPAGER 907



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 95/400 (23%), Positives = 146/400 (36%), Gaps = 56/400 (14%)

Query: 1441 CSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGRISGLCFKKL 1500
            C    +   ++FDG         +Y+LV   G+       +  +     G  +    + +
Sbjct: 925  CQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAV 984

Query: 1501 NVTTPIHKIIVNR-LARKVEVDSIVVPLPFSSQELSIE--DSGSMYVITTPAGLIIKW-- 1555
             V     K+ V R    +V VD ++  LPF + +  ++    G   V+ T  GL + +  
Sbjct: 985  RVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDW 1044

Query: 1556 -SHLTGIIDIHFGFRFNLSSYTEGLCGIC---NEDPDDDLRMQNGTIITNMEDIGLFIES 1611
             + +T  +          SSY E LCG+C   N DP DDL ++ G    N    G    S
Sbjct: 1045 NARVTAKVP---------SSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFG---NS 1092

Query: 1612 WEIEKSFEVTMRRPVRNCTEH-DCSQCIDLLNRRI---------------FIPCHDKVSP 1655
            W+ E        RP    TE  DC +   L+ +++               F  CH K+ P
Sbjct: 1093 WQEET-------RPGCGATEPGDCPKLDSLVAQQLQSKNECGILADPKGPFRECHSKLDP 1145

Query: 1656 EDFCEKMWINYTYFWNYE---CDALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQP 1711
            +        +           CDAL+ Y A C      +  WR+ + C LSCP    Y+ 
Sbjct: 1146 QGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEA 1205

Query: 1712 CVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPR 1771
            C   C   +C +    G        E CVC  G  L       C+P   C C   +    
Sbjct: 1206 CSYGCPL-SCGDLPVPGGCGS-ECHEGCVCDEGFAL---SGESCLPLASCGCV-HQGTYH 1259

Query: 1772 TAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCE 1811
              G+ +  G    +L  C E G +      C   P   C+
Sbjct: 1260 PPGQTFYPGPGCDSLCHCQEGGLVSCESSSCG--PHEACQ 1297


>gi|239755776 PREDICTED: similar to Mucin-19 [Homo sapiens]
          Length = 1950

 Score =  247 bits (630), Expect = 1e-64
 Identities = 157/535 (29%), Positives = 249/535 (46%), Gaps = 35/535 (6%)

Query: 282  YIASCVNDLCKTDDDETYCRAATEYARACSHAGY-PIQDWRDDFPAC--TDKCDDSFVHR 338
            Y   C+++ C+T D  + C   +E +R C+  G    + WR D      T +C +  +++
Sbjct: 688  YKMICIDEYCQTRDKTSTCDTYSELSRLCASDGPGTFESWRSDSDVVCETQRCPEQHIYK 747

Query: 339  DCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDN----GTCISLENCPCGFHGLAYS 394
            +C    P TC+       S   C+ GC CP+G ++D+    G C+    CPC   G  Y 
Sbjct: 748  ECGPSNPATCSNVAPFQDSE--CVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQ 805

Query: 395  VGSKIEQEC-TECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKG 453
             G   E  C ++C C    W+CTE  CP +C V G S  TTFDG  Y+F G C ++ V  
Sbjct: 806  PGEVREGPCGSQCTCQDAKWSCTEALCPGRCKVEGSS-LTTFDGVKYNFPGNCHFLAVHN 864

Query: 454  TGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSP---NQGFNL 510
               + ++I+++  PC       CL S+TL+L         +      +T+    NQG+  
Sbjct: 865  ---EDWSISVELRPCPSGQTGTCLNSVTLLLNSSVPVDKYVFNSDGTVTNDKIRNQGYYY 921

Query: 511  NGIVEIQTLSSLFILLKTTFGLKILFAI-DGERIYIQLTSAWKRRTLGLCGTFNGNIRDD 569
            +  ++I   SS ++ ++T F +K+   I    ++Y+ +       T+GLCG++N    DD
Sbjct: 922  SDKIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDD 981

Query: 570  FLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQEL--F 627
            F+S   ++E T Q  AN+W + S    P   P    C   ++      HC ++       
Sbjct: 982  FMSSQNILEKTSQAFANSWEMMS---CPKGNP--SSCISIEKEKFAERHCGILLDSSGPL 1036

Query: 628  APCHIYISPGLYYQLCRHDACKCGSS--CLCNALAHYAYLCGQHGVPI-DFRTQISFCAV 684
            A CH  ++P  Y++ C+   C C +S  CLC  L +Y   C +    I  +RT    C  
Sbjct: 1037 ASCHPIVNPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRT--GLCEH 1094

Query: 685  VCQKGMLYHHCSSFCLHSCISLSSPEQ---CSDDCAEGCNCPEGKFYEDTLNFCVPIFHC 741
             C  G+++ +    C  SC SLS  ++     D   +GC CP+   Y++    CV    C
Sbjct: 1095 SCPSGLVFKYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDA-MYQNNEGNCVLKSQC 1153

Query: 742  RCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFP 796
             C+    V QPG+LI T    C C +G + C ++     +  C  G EY DC  P
Sbjct: 1154 DCYINDEVMQPGKLIHTDDNKCVCRDGILLC-QIPIDLTLQNCSGGAEYVDCSDP 1207



 Score =  116 bits (290), Expect = 3e-25
 Identities = 109/451 (24%), Positives = 177/451 (39%), Gaps = 50/451 (11%)

Query: 62   GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRS 121
            G CK  G     TFDG+ Y FPGNC ++   +       +++ V   P   G   +C  S
Sbjct: 834  GRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHN-----EDWSISVELRPCPSGQTGTCLNS 887

Query: 122  ISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKL------ADYILVKTTFGFSLA 175
            ++L  ++   +  Y        ++    +  G  + +K+      + Y+ V+T F   L 
Sbjct: 888  VTLLLNSSVPVDKYVFN-SDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQ 946

Query: 176  WD--GISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPD 233
                 +  +Y+ +  +    + GLCG+YN+   DDF+  Q    +    FANSW + +  
Sbjct: 947  IQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMS-- 1004

Query: 234  DTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQF--PFLSCHEYIDPYLYIASCVNDLC 291
                   P   P+ C S +   +     C ILL    P  SCH  ++P  Y   C    C
Sbjct: 1005 ------CPKGNPSSCIS-IEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTC 1057

Query: 292  KTDD-DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTF 350
              ++  +  C     Y +AC+     I  WR     C   C    V +  +  C  +C  
Sbjct: 1058 TCENSQDCLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACNSSCRS 1115

Query: 351  ----EKQCLGSNLHCLDGCYCPDGLVMDN-GTCISLENCPCGFHGLAYSVGSKIEQECTE 405
                ++ C   ++  +DGC CPD +  +N G C+    C C  +      G  I  +  +
Sbjct: 1116 LSERDRSCDVEDVP-VDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPGKLIHTDDNK 1174

Query: 406  CVCVGGVWNC------TEQDCP-----VQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGT 454
            CVC  G+  C      T Q+C      V CS   D        R  S   +  +    G 
Sbjct: 1175 CVCRDGILLCQIPIDLTLQNCSGGAEYVDCS---DPKAQRRTNRTCSTRNIPVFDDYCGH 1231

Query: 455  GKDKFTITLQKAPCEQNLGLVCLQSITLILE 485
                F I  +  PC ++ GL C + I +  +
Sbjct: 1232 ENGTFRILTESVPCCED-GLTCSRKIIVAFQ 1261



 Score =  100 bits (249), Expect = 2e-20
 Identities = 78/245 (31%), Positives = 97/245 (39%), Gaps = 29/245 (11%)

Query: 191  KGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSV-QTPDDTKCVLTPSDFPNPCS 249
            +GK CGLCGN N    DDF             F NSW   Q   DT     P D    C 
Sbjct: 1261 QGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQTFPCDSNPYCK 1320

Query: 250  SGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETY---CRAATEY 306
            +          KC+IL    F  CH  +DP  Y   C+ + C  D +  Y   C A   Y
Sbjct: 1321 AWAVR------KCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMY 1374

Query: 307  ARACSHAGYPIQDWRDDFPACTDKCD-------DSFVHRDCISCCPPTCTFEKQCLGSNL 359
            A ACS  G  +  WR     C   CD         + +  C +    TC  + Q +G   
Sbjct: 1375 AEACSAVGVCV-SWRKP-NLCPVYCDYYNAPGECRWHYEPCGTVTAKTC--KDQLVGQKF 1430

Query: 360  -HCLDGCY--CPDGL-VMDNGT--CISLENCPCGFHGLAYSVGSKIEQEC-TECVCVGGV 412
               L+GCY  CPD    +D  T  C+SL  C C F+      G  IE  C   C C+ G 
Sbjct: 1431 SSLLEGCYAKCPDSAPYLDENTMKCVSLSECSC-FYNDVIPAGGVIEDNCGRTCYCIAGQ 1489

Query: 413  WNCTE 417
              C+E
Sbjct: 1490 LECSE 1494



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 46/147 (31%), Positives = 74/147 (50%), Gaps = 1/147 (0%)

Query: 970  KVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQ-CESPDETIKPCE 1028
            K+   ++ K+ GLCGN +    +D TT  +     A  FG+SW   Q C        PC+
Sbjct: 1255 KIIVAFQGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTVAQTFPCD 1314

Query: 1029 AHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAY 1088
            ++     +A ++C IL    F  C N +D +++   C E+ C C++ G     CT++A Y
Sbjct: 1315 SNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGFCTAVAMY 1374

Query: 1089 AYKCCQEGISIHWRSSTVCSLDCEYYN 1115
            A  C   G+ + WR   +C + C+YYN
Sbjct: 1375 AEACSAVGVCVSWRKPNLCPVYCDYYN 1401



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 21/254 (8%)

Query: 539  DGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPV 598
            DG     ++  A++ +  GLCG  NG+++DDF +    +        N+W+ S  C    
Sbjct: 1248 DGLTCSRKIIVAFQGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDT- 1306

Query: 599  HVPVVDPCNINQQNIGYAAH-CDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSS---- 653
             V    PC+ N     +A   C+++    F  CH  + P  Y+ +C  +AC C       
Sbjct: 1307 -VAQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYL 1365

Query: 654  CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC-------QKGMLYHHCSSFCLHSCISL 706
              C A+A YA  C   GV + +R + + C V C       +    Y  C +    +C   
Sbjct: 1366 GFCTAVAMYAEACSAVGVCVSWR-KPNLCPVYCDYYNAPGECRWHYEPCGTVTAKTCKDQ 1424

Query: 707  SSPEQCSDDCAEGC--NCPEGKFY--EDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGL 762
               ++ S    EGC   CP+   Y  E+T+  CV +  C C Y   +   G +       
Sbjct: 1425 LVGQKFS-SLLEGCYAKCPDSAPYLDENTMK-CVSLSECSCFYNDVIPAGGVIEDNCGRT 1482

Query: 763  CQCSNGTVKCDELA 776
            C C  G ++C E A
Sbjct: 1483 CYCIAGQLECSETA 1496



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 89/381 (23%), Positives = 149/381 (39%), Gaps = 77/381 (20%)

Query: 784  CPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPG-------- 835
            CPE   Y +C    P  PA       TC+N+A        S C+SGC C  G        
Sbjct: 740  CPEQHIYKEC---GPSNPA-------TCSNVAP----FQDSECVSGCTCPEGYLLDDIGE 785

Query: 836  ---------------------------------VCRRGMFNCTYYPCPAVCTIYGDRHYY 862
                                              C+   ++CT   CP  C + G     
Sbjct: 786  KGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQDAKWSCTEALCPGRCKVEGSS-LT 844

Query: 863  SFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDI-VCSKSVLISVG-----DTE 916
            +FDG++Y++  +C  FL    +D  ISV  + + C       C  SV + +      D  
Sbjct: 845  TFDGVKYNFPGNCH-FLAVHNEDWSISV--ELRPCPSGQTGTCLNSVTLLLNSSVPVDKY 901

Query: 917  IYLND---TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGP 973
            ++ +D   T  K +  G++  +K       + Y  V  +    + I       +++ + P
Sbjct: 902  VFNSDGTVTNDKIRNQGYYYSDKIQIFNASSSYLQVETYFHVKLQIQIVPVMQLYVSMPP 961

Query: 974  QWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNK 1033
                   GLCG+++    +D  +S N+  + ++ F +SW +  C  P      C + + K
Sbjct: 962  NQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQAFANSWEMMSC--PKGNPSSCISIE-K 1018

Query: 1034 FPYAKKECSILY--SDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYK 1091
              +A++ C IL   S   ASC  +++   + + C + TC C    D  CLCT +  Y   
Sbjct: 1019 EKFAERHCGILLDSSGPLASCHPIVNPKPYHEECKKYTCTCENSQD--CLCTILGNYVKA 1076

Query: 1092 CCQ-EGISIHWRSSTVCSLDC 1111
            C + E   + WR+  +C   C
Sbjct: 1077 CAEKETYIVGWRTG-LCEHSC 1096



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 146/684 (21%), Positives = 230/684 (33%), Gaps = 155/684 (22%)

Query: 1432 CPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPSGR 1491
            C E  CP RC +    S+ TFDG          ++ V      I   +  C     PSG+
Sbjct: 827  CTEALCPGRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHNEDWSISVELRPC-----PSGQ 880

Query: 1492 ISGLCFKK----LNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITT 1547
             +G C       LN + P+ K + N     V  D I     + S ++ I ++ S Y+   
Sbjct: 881  -TGTCLNSVTLLLNSSVPVDKYVFNSDGT-VTNDKIRNQGYYYSDKIQIFNASSSYLQVE 938

Query: 1548 PAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGL 1607
                +     +  ++ ++     N  + T GLCG  N   +DD  M +  I+        
Sbjct: 939  TYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDF-MSSQNILEKTSQA-- 995

Query: 1608 FIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRI--------------FIPCHDKV 1653
            F  SWE+             +C + + S CI +   +                  CH  V
Sbjct: 996  FANSWEM------------MSCPKGNPSSCISIEKEKFAERHCGILLDSSGPLASCHPIV 1043

Query: 1654 SPEDF---CEKMWINYTYFWNYECDALSAYVALC-NKFDICIQWRTPDYCSLSCPEGKEY 1709
            +P+ +   C+K         +  C  L  YV  C  K    + WRT   C  SCP G  +
Sbjct: 1044 NPKPYHEECKKYTCTCENSQDCLCTILGNYVKACAEKETYIVGWRT-GLCEHSCPSGLVF 1102

Query: 1710 QPCVRPCEAR---------------------TCLNQWFYGHTSCLNLREDCVCKVGTILH 1748
            +  V+ C +                      TC +  +  +     L+  C C +   + 
Sbjct: 1103 KYNVKACNSSCRSLSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVM 1162

Query: 1749 RPHSAQCIPEKECA---------------------------CTDSEDQPRTAGEIWNGGI 1781
            +P       + +C                            C+D + Q RT        I
Sbjct: 1163 QPGKLIHTDDNKCVCRDGILLCQIPIDLTLQNCSGGAEYVDCSDPKAQRRTNRTCSTRNI 1222

Query: 1782 DECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSK-------EVCGC 1834
                 Y   ENG+   +      E  P CE          D  TC  K       +VCG 
Sbjct: 1223 PVFDDYCGHENGTFRIL-----TESVPCCE----------DGLTCSRKIIVAFQGKVCGL 1267

Query: 1835 ----------DTTLCETSIPTCT----NSQKLIVGHSPLSCCPQYKCECDPLKCPSISTP 1880
                      D T   +S+ +      NS K     S  +    + C+ +P  C + +  
Sbjct: 1268 CGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSD-TVAQTFPCDSNPY-CKAWAVR 1325

Query: 1881 EC---REDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYC 1937
            +C   R+  F     + +P  +   C+ E+C   +   + G F T        C     C
Sbjct: 1326 KCEILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLG-FCTAVAMYAEACSAVGVC 1384

Query: 1938 VC--EPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCE---VGE-FTA 1991
            V   +PNLCP         +     N  G+C   WH E  C  +   TC+   VG+ F++
Sbjct: 1385 VSWRKPNLCP---------VYCDYYNAPGEC--RWHYE-PCGTVTAKTCKDQLVGQKFSS 1432

Query: 1992 IDHNFQSDC-GCIQYLCEKDDVCV 2014
            +     + C     YL E    CV
Sbjct: 1433 LLEGCYAKCPDSAPYLDENTMKCV 1456



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 52/209 (24%), Positives = 83/209 (39%), Gaps = 34/209 (16%)

Query: 1578 GLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCS-- 1635
            GLCG  N D  DD   +  ++ +   + G    SW+  +    T+ +     +   C   
Sbjct: 1266 GLCGNNNGDLKDDFTTRYSSVASGALEFG---NSWKTSQECSDTVAQTFPCDSNPYCKAW 1322

Query: 1636 ---QCIDLLNRRIFIPCHDKVSPE---DFCEK------MWINYTYFWNYECDALSAYVAL 1683
               +C ++L    F  CH+KV P    D C +      M   Y  F    C A++ Y   
Sbjct: 1323 AVRKC-EILRDSTFRDCHNKVDPSAYHDVCIEEACACDMEGKYLGF----CTAVAMYAEA 1377

Query: 1684 CNKFDICIQWRTPDYCSLSCPEGK-------EYQPCVRPCEARTCLNQWFYGHTSCLNLR 1736
            C+   +C+ WR P+ C + C            Y+PC     A+TC +Q      S  +L 
Sbjct: 1378 CSAVGVCVSWRKPNLCPVYCDYYNAPGECRWHYEPC-GTVTAKTCKDQLVGQKFS--SLL 1434

Query: 1737 EDCV--CKVGTILHRPHSAQCIPEKECAC 1763
            E C   C         ++ +C+   EC+C
Sbjct: 1435 EGCYAKCPDSAPYLDENTMKCVSLSECSC 1463



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 26/57 (45%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 1277 CEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNM-ILDEVTLKCVYPRDC 1332
            C W YEPC T   KTC D + +  KF   +EGC   CP +   LDE T+KCV   +C
Sbjct: 1406 CRWHYEPCGTVTAKTCKD-QLVGQKFSSLLEGCYAKCPDSAPYLDENTMKCVSLSEC 1461



 Score = 31.6 bits (70), Expect = 9.2
 Identities = 10/33 (30%), Positives = 19/33 (57%)

Query: 62  GICKTWGQYHFETFDGIYYYFPGNCSYIFAKDC 94
           G   TW +  +++F+G  ++F  +C Y F + C
Sbjct: 595 GEISTWSKGAYKSFNGRIFFFESSCPYTFCRHC 627


>gi|37693519 BMP-binding endothelial regulator precursor protein
           [Homo sapiens]
          Length = 685

 Score =  159 bits (403), Expect = 2e-38
 Identities = 98/330 (29%), Positives = 145/330 (43%), Gaps = 10/330 (3%)

Query: 60  RDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCY 119
           + G+C  +G  H+ TFDG  + F G C Y+  KDC      + V V N  +   S +S  
Sbjct: 360 KPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRS-FSWT 418

Query: 120 RSISLFFSNQEEIRIYGH-EIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDG 178
           +S+ L    +  + +  H  ++ NG  + LP       I+     + V T  G  ++WDG
Sbjct: 419 KSVELVLG-ESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKAGLEISWDG 477

Query: 179 ISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCV 238
            S + +  +   KGK CGLCGNYN  + DD I    ++  D+  FA SW V++ +     
Sbjct: 478 DSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCN-- 535

Query: 239 LTPSDFPNP--CSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTD-D 295
             P   P P  C   +        +CQ L  + F +CH  +D   +  SCV D+C+    
Sbjct: 536 -RPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVH 594

Query: 296 DETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCL 355
              YC +   Y RAC   G  +  W         +C    V+  C   C  TC    +  
Sbjct: 595 KNCYCESFLAYTRACQREGIKVH-WEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIG 653

Query: 356 GSNLHCLDGCYCPDGLVMDNGTCISLENCP 385
             N  C+ GC+CP  LV+  G CI    CP
Sbjct: 654 PCNKPCVAGCHCPANLVLHKGRCIKPVLCP 683



 Score =  143 bits (361), Expect = 2e-33
 Identities = 126/475 (26%), Positives = 196/475 (41%), Gaps = 54/475 (11%)

Query: 265 LLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYCRAATEYA-RACSHAGYPIQDWRDD 323
           +   PF SC    D Y   +S + D C        CR +T    R CSH G   Q     
Sbjct: 230 VFDLPFGSCLFRSDVYDNGSSFLYDNCTA----CTCRDSTVVCKRKCSHPGGCDQGQE-- 283

Query: 324 FPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLV-MDNGTCISLE 382
              C ++C       D   C      F+   + S+++C   C C  G     N  CI + 
Sbjct: 284 --GCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTI-CACVKGRTECRNKQCIPIS 340

Query: 383 NCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSF 442
           +CP G          KI      C        CTE+  P  C+V GD H+ TFDGR ++F
Sbjct: 341 SCPQG----------KILNRKGCCPI------CTEK--PGVCTVFGDPHYNTFDGRTFNF 382

Query: 443 IGMCQYILVKGTGKDKFTI-TLQKAPCEQNLGLVCLQSITLILEDD---FNKQVTLGRGG 498
            G CQY+L K           L K    +       +S+ L+L +      + +T+   G
Sbjct: 383 QGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNG 442

Query: 499 QILTSPNQG--FNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSA--WKRR 554
             +  P +   F+++       L    + + T  GL+I +  DG+  ++++ +A   K +
Sbjct: 443 SRIALPCRAPHFHID-------LDGYLLKVTTKAGLEISW--DGDS-FVEVMAAPHLKGK 492

Query: 555 TLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSST--CFAPVHVPVVDPCNINQQN 612
             GLCG +NG+ RDD +   G  +      A +WRV S   C  P   PV + C      
Sbjct: 493 LCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQ-GTVK 551

Query: 613 IGYAAH--CDVIHQELFAPCHIYISPGLYYQLCRHDACKCG--SSCLCNALAHYAYLCGQ 668
           +   AH  C  +    F  CH  +    +Y+ C  D C+C    +C C +   Y   C +
Sbjct: 552 VKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRACQR 611

Query: 669 HGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCP 723
            G+ + +  Q +  A  C+ G +Y  C   C+ +C + +    C+  C  GC+CP
Sbjct: 612 EGIKVHWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNKPCVAGCHCP 666



 Score =  125 bits (313), Expect = 6e-28
 Identities = 102/406 (25%), Positives = 162/406 (39%), Gaps = 58/406 (14%)

Query: 743  CHYRGSVYQPGE-LIPTPSGLCQCSNGTVKCDELAT---------------------PSA 780
            C +R  VY  G   +      C C + TV C    +                     P  
Sbjct: 238  CLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPED 297

Query: 781  VHICPEGKEYFDCRFPDPELPAGGVNCETTCANL-----AMNFTCTPSSPCISGCV---- 831
            + +C  G + F     D E+ +  +NC T CA +       N  C P S C  G +    
Sbjct: 298  IKVCKFGNKIFQ----DGEMWSS-INC-TICACVKGRTECRNKQCIPISSCPQGKILNRK 351

Query: 832  -CAPGVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIK--SADDSDI 888
             C P +C            P VCT++GD HY +FDG  +++   CQ  L K  S+  S  
Sbjct: 352  GCCP-ICTEK---------PGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPF 401

Query: 889  SVIAQNKKCFDNDIVCSKSVLISVGDTEIYLND-TPYKQKQSGFFLENKSTYQLWKAGYY 947
             V+ +N          +KSV + +G++ + L      +   S   L  ++ +       Y
Sbjct: 402  QVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGY 461

Query: 948  IVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARV 1007
            ++    +  + I WD  + + +   P  K KL GLCGN++    +D+   +     +   
Sbjct: 462  LLKVTTKAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDD 521

Query: 1008 FGDSWALGQ---CESPDETIKP--CEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFA 1062
            F +SW +     C  P     P  C+        A +EC  L S  F +C + +D  +F 
Sbjct: 522  FAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFY 581

Query: 1063 KNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCS 1108
            ++C  D C C +  +  C C S  AY   C +EGI +HW     C+
Sbjct: 582  RSCVTDMCECPVHKN--CYCESFLAYTRACQREGIKVHWEPQQNCA 625



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 83/359 (23%), Positives = 130/359 (36%), Gaps = 47/359 (13%)

Query: 1426 VNSDICCPEW-ECPCRCSMLSELSIITFDGNNAALYSMASYILVR------IPGEIIVAH 1478
            +N   CCP   E P  C++  +    TFDG          Y+L +       P +++V +
Sbjct: 348  LNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKN 407

Query: 1479 IEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIED 1538
              + + + + +  +  L   +  V+   H  +    +R        + LP  +    I+ 
Sbjct: 408  DARRTRSFSWTKSVE-LVLGESRVSLQQHLTVRWNGSR--------IALPCRAPHFHIDL 458

Query: 1539 SGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTI 1598
             G +  +TT AGL I W    G   +      +L     GLCG  N    DDL   +G  
Sbjct: 459  DGYLLKVTTKAGLEISWD---GDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNF 515

Query: 1599 ITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDL----------LNRRIFIP 1648
              +++D   F ESW +E +      RP R      C   + +          L    F  
Sbjct: 516  KFDVDD---FAESWRVESN--EFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQT 570

Query: 1649 CHDKVSPEDF---CEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLS-CP 1704
            CH  V    F   C           N  C++  AY   C +  I + W     C+ + C 
Sbjct: 571  CHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQNCAATQCK 630

Query: 1705 EGKEYQPCVRPCEARTCLNQWFYG--HTSCLNLREDCVCKVGTILHRPHSAQCIPEKEC 1761
             G  Y  C   C  +TC N    G  +  C+     C C    +LH+    +CI    C
Sbjct: 631  HGAVYDTCGPGC-IKTCDNWNEIGPCNKPCV---AGCHCPANLVLHK---GRCIKPVLC 682



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 87/392 (22%), Positives = 140/392 (35%), Gaps = 100/392 (25%)

Query: 1825 TCCSKEVCGCD-------TTLCETSIPTCTNSQKLI----VGHSP--LSCCPQYKCECDP 1871
            TCC   +  C        ++    S+  C N  +++    +  +P  +  C   +  C  
Sbjct: 22   TCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTCKR 81

Query: 1872 LKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFC 1931
             KCP +S  +C      + ++Q   CC      C+ CT      ++G       +S  + 
Sbjct: 82   EKCPVLSR-DCA-----LAIKQRGACCEQ----CKGCT------YEGNTYN---SSFKWQ 122

Query: 1932 CPQYYCV---CEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLVMPTCEV-- 1986
             P   CV   C+  +     + C        E++ G CCPT      C   V    +   
Sbjct: 123  SPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHL-GMCCPT------CPGCVFEGVQYQE 175

Query: 1987 GEFTAIDHNFQSDCGCI--QYLCEKDDVCVF----QEVSVLNPGQSMIKYLEEDFCYTI- 2039
            GE    + +  + C C   +  C ++ VC      Q +S + PGQ   K L +   + + 
Sbjct: 176  GEEFQPEGSKCTKCSCTGGRTQCVRE-VCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLP 234

Query: 2040 --ECL---EEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPS-----DYGCCGTC----- 2084
               CL   +  DN + F   N T   C     V +     P        GCC  C     
Sbjct: 235  FGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVP 294

Query: 2085 -KNVS-CKFHMENGTSVVYAVGSTWH-YNCTTYECVKTDEGAIILNYTMVCPPFNETECK 2141
             +++  CKF  +     ++  G  W   NCT   CVK                   TEC+
Sbjct: 295  PEDIKVCKFGNK-----IFQDGEMWSSINCTICACVK-----------------GRTECR 332

Query: 2142 MNEGIV-------KLYN-EGCCKICKREERIC 2165
              + I        K+ N +GCC IC  +  +C
Sbjct: 333  NKQCIPISSCPQGKILNRKGCCPICTEKPGVC 364



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 36/126 (28%), Positives = 54/126 (42%), Gaps = 34/126 (26%)

Query: 329 DKCDDSFVHRDCI-------SCCPPT--CTFEKQCLGSNLHC---LDGCY---CPDGLVM 373
           +KC    + RDC        +CC     CT+E     S+       + C    C +G+V 
Sbjct: 82  EKCP--VLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVT 139

Query: 374 DNGT-CI-----SLEN-------CP-CGFHGLAYSVGSKIEQE---CTECVCVGGVWNCT 416
           ++G  C+      LE+       CP C F G+ Y  G + + E   CT+C C GG   C 
Sbjct: 140 ESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCV 199

Query: 417 EQDCPV 422
            + CP+
Sbjct: 200 REVCPI 205



 Score = 33.5 bits (75), Expect = 2.4
 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 4/52 (7%)

Query: 1281 YEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDC 1332
            Y+ C   C KTC +   +     P V GC  +CP N++L +   +C+ P  C
Sbjct: 635  YDTCGPGCIKTCDNWNEIGPCNKPCVAGC--HCPANLVLHKG--RCIKPVLC 682


>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
          Length = 1503

 Score =  144 bits (364), Expect = 7e-34
 Identities = 126/481 (26%), Positives = 189/481 (39%), Gaps = 99/481 (20%)

Query: 343  CCPPTCTFEKQC----LGSNLHCLDGCY---------------CPDGLV------MDNGT 377
            CCP        C    LGS L   D CY               CP+            G+
Sbjct: 1015 CCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGS 1074

Query: 378  CISLENCP---CGFHGLAYSVGSKIEQE-CTECVCVGGVWNCTEQDC------------- 420
            C  +   P   C   G   + G +   + CT C C+ G   C  Q C             
Sbjct: 1075 CCPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPAL 1134

Query: 421  ------------PVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPC 468
                        P  C   GD H+ TFDGR   F G C Y+L K      F++ +     
Sbjct: 1135 SPGSCCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGDFSVHVTNDDR 1194

Query: 469  EQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQ---GFNLNGIVEIQTLSSLFIL 525
             ++ G+   Q + ++L D     V L + G +    +     F    ++ ++ L    ++
Sbjct: 1195 GRS-GVAWTQEVAVLLGD---MAVRLLQDGAVTVDGHPVALPFLQEPLLYVE-LRGHTVI 1249

Query: 526  LKTTFGLKILFAIDGE-RIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLH 584
            L    GL++L+  DG+ ++ + +  +++ RT GLCG FNG  +DD   P G++  +    
Sbjct: 1250 LHAQPGLQVLW--DGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAF 1307

Query: 585  ANAWRVSS------TCFAPVHVPVVDPCNINQQNIGYA------AHCDVIHQELFAPCHI 632
             N+W+VS        C A      VDPC    +  GY       A C V+    F+ CH 
Sbjct: 1308 GNSWQVSEGLWPGRPCSAGRE---VDPC----RAAGYRARREANARCGVLKSSPFSRCHA 1360

Query: 633  YISPGLYYQLCRHDACKCG-----SSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC- 686
             + P  ++  C +D C CG      +CLC+AL  YA  C Q GV   +R   + C V C 
Sbjct: 1361 VVPPEPFFAACVYDLCACGPGSSADACLCDALEAYASHCRQAGVTPTWRGP-TLCVVGCP 1419

Query: 687  -QKGMLYHHCSSFCLHSCISLSSP-----EQCSDDCAEGCNCPEGKFYEDTLNFCVPIFH 740
             ++G ++  C   C  +C +   P       C   C  GC CP G    +    C+P   
Sbjct: 1420 LERGFVFDECGPPCPRTCFNQHIPLGELAAHCVRPCVPGCQCPAGLVEHEA--HCIPPEA 1477

Query: 741  C 741
            C
Sbjct: 1478 C 1478



 Score =  137 bits (345), Expect = 1e-31
 Identities = 99/341 (29%), Positives = 147/341 (43%), Gaps = 22/341 (6%)

Query: 60   RDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDC--GDLEPRYTVWVHNSPKCLGSVYS 117
            R   C  +G  H+ TFDG   +F G+CSY+ AKDC  GD    ++V V N  +    V +
Sbjct: 1146 RPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGD----FSVHVTNDDRGRSGV-A 1200

Query: 118  CYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQI-FIEKLADYILVKTTFGFSLAW 176
              + +++   +     +    +  +G  + LP     + ++E     +++    G  + W
Sbjct: 1201 WTQEVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELRGHTVILHAQPGLQVLW 1260

Query: 177  DGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTK 236
            DG S + + +   ++G++CGLCGN+N    DD    +       A F NSW V       
Sbjct: 1261 DGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSEGLWPG 1320

Query: 237  CVLTPSDFPNPC-SSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCK--- 292
               +     +PC ++G  A      +C +L   PF  CH  + P  + A+CV DLC    
Sbjct: 1321 RPCSAGREVDPCRAAGYRARREANARCGVLKSSPFSRCHAVVPPEPFFAACVYDLCACGP 1380

Query: 293  -TDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKC--DDSFVHRDCISCCPPTCT 349
             +  D   C A   YA  C  AG     WR     C   C  +  FV  +C   CP TC 
Sbjct: 1381 GSSADACLCDALEAYASHCRQAGV-TPTWRGP-TLCVVGCPLERGFVFDECGPPCPRTCF 1438

Query: 350  FEKQCLGSNL-----HCLDGCYCPDGLVMDNGTCISLENCP 385
             +   LG         C+ GC CP GLV     CI  E CP
Sbjct: 1439 NQHIPLGELAAHCVRPCVPGCQCPAGLVEHEAHCIPPEACP 1479



 Score =  133 bits (335), Expect = 2e-30
 Identities = 116/446 (26%), Positives = 171/446 (38%), Gaps = 62/446 (13%)

Query: 699  CLHSCISLSSPEQCSDDCAEGC-NCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIP 757
            C  S +    P+ C   CAE   NC EG                     GS   P    P
Sbjct: 1002 CPPSQLLPPGPQHCCPTCAEALSNCSEGLL-------------------GSELAP----P 1038

Query: 758  TPSGLCQCSNGT-----VKCDELATPSAVHICPEGKEYFDCRFPDPELPAGG-------- 804
             P   CQC + T       C EL+ P +    P G     CR P       G        
Sbjct: 1039 DPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREVASGER 1098

Query: 805  --VNCETTCANLAMNFTCTPS--SPCISGCVCAPGVCRRGMFNCTYYPCPAVCTIYGDRH 860
              V+  T+C+ +A    C     SP   G   AP +   G       P PA C  +GD H
Sbjct: 1099 WTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSP-GSCCPRCLPRPASCMAFGDPH 1157

Query: 861  YYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLN 920
            Y +FDG    +   C   L K     D SV   N     + +  ++ V + +GD  + L 
Sbjct: 1158 YRTFDGRLLHFQGSCSYVLAKDCHSGDFSVHVTNDDRGRSGVAWTQEVAVLLGDMAVRLL 1217

Query: 921  D----TPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWK 976
                 T      +  FL+    Y   +   + V+   +  + +LWD ++ + + V   ++
Sbjct: 1218 QDGAVTVDGHPVALPFLQEPLLYVELRG--HTVILHAQPGLQVLWDGQSQVEVSVPGSYQ 1275

Query: 977  NKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFP- 1035
             +  GLCGNF+    +D+     L + +   FG+SW + +   P    +PC A +   P 
Sbjct: 1276 GRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSEGLWPG---RPCSAGREVDPC 1332

Query: 1036 ---------YAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCE-CLCTSI 1085
                      A   C +L S  F+ C  V+    F   C  D C C  G   + CLC ++
Sbjct: 1333 RAAGYRARREANARCGVLKSSPFSRCHAVVPPEPFFAACVYDLCACGPGSSADACLCDAL 1392

Query: 1086 AAYAYKCCQEGISIHWRSSTVCSLDC 1111
             AYA  C Q G++  WR  T+C + C
Sbjct: 1393 EAYASHCRQAGVTPTWRGPTLCVVGC 1418



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 91/357 (25%), Positives = 128/357 (35%), Gaps = 43/357 (12%)

Query: 1431 CCPEW-ECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQAPS 1489
            CCP     P  C    +    TFDG         SY+L +        H    S++    
Sbjct: 1139 CCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKD------CHSGDFSVHVTND 1192

Query: 1490 GR-ISGLCFKKLNVTTPIHKIIVNRLAR-KVEVDSIVVPLPFSSQELS-IEDSGSMYVIT 1546
             R  SG+ + +  V   +  + V  L    V VD   V LPF  + L  +E  G   ++ 
Sbjct: 1193 DRGRSGVAWTQ-EVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELRGHTVILH 1251

Query: 1547 TPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIG 1606
               GL + W    G   +      +    T GLCG  N    DDL+   G ++ +    G
Sbjct: 1252 AQPGLQVLWD---GQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFG 1308

Query: 1607 LFIESWEIEKSF----------EVTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPE 1656
                SW++ +            EV   R        + +    +L    F  CH  V PE
Sbjct: 1309 ---NSWQVSEGLWPGRPCSAGREVDPCRAAGYRARREANARCGVLKSSPFSRCHAVVPPE 1365

Query: 1657 DFCEKMWINYTYFWNYE------CDALSAYVALCNKFDICIQWRTPDYCSLSCP--EGKE 1708
             F      +              CDAL AY + C +  +   WR P  C + CP   G  
Sbjct: 1366 PFFAACVYDLCACGPGSSADACLCDALEAYASHCRQAGVTPTWRGPTLCVVGCPLERGFV 1425

Query: 1709 YQPCVRPCEARTCLNQWF-YGHTSCLNLR---EDCVCKVGTILHRPHSAQCIPEKEC 1761
            +  C  PC  RTC NQ    G  +   +R     C C  G + H  H   CIP + C
Sbjct: 1426 FDECGPPC-PRTCFNQHIPLGELAAHCVRPCVPGCQCPAGLVEHEAH---CIPPEAC 1478



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 42/160 (26%), Positives = 55/160 (34%), Gaps = 49/160 (30%)

Query: 743 CHYRGSVYQPGELIPTPSG---LCQCSNGTVKCDELAT-------PSAVHICP--EGKEY 790
           C Y+G  +  GE  P+P+    LC C  G+V C+  A        P+    CP  +G EY
Sbjct: 662 CLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEY 721

Query: 791 F------DCRFPDPELP-------AGGVNC-ETTCANLAMNFTCTPSSPCISGC------ 830
                  +  FPDP  P        G V C    C     +    PS  C   C      
Sbjct: 722 LGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYH 781

Query: 831 ----------------VCAPGVCRRGMFNCTYYPC-PAVC 853
                            C+   C+ G   C   PC PA+C
Sbjct: 782 GVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALC 821



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 63/268 (23%), Positives = 87/268 (32%), Gaps = 62/268 (23%)

Query: 627  FAP-CHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVV 685
            F P CH  +S G  +Q         GS   C   A           P+  + Q++     
Sbjct: 830  FCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSC 889

Query: 686  CQK--GMLYHH---------------CSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFY 728
            C +  G L H                CSS   H  +   +  QC   CA+    P     
Sbjct: 890  CPRCRGCLAHGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHD--- 946

Query: 729  EDTLNFCVPIFHCR-CHYRGSVYQPGELI---PTPSGLCQC-----SNGTVKCDELATPS 779
                  C P   C  C + G  Y+PGE       P  +C C        +++C     PS
Sbjct: 947  ------CCP--QCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPS 998

Query: 780  AVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFT-------CTPSSPCISGCVC 832
             V  CP          P   LP G  +C  TCA    N +         P  PC +   C
Sbjct: 999  LVG-CP----------PSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYT---C 1044

Query: 833  APGVCRRGMFNCTYYPCPAVCTIYGDRH 860
                C+   + C +  CP +     +RH
Sbjct: 1045 Q---CQDLTWLCIHQACPELSCPLSERH 1069



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 72/315 (22%), Positives = 102/315 (32%), Gaps = 91/315 (28%)

Query: 594 CFAPVHVPVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSS 653
           C    H+P    C+ N Q  G        + E F+P                DAC     
Sbjct: 126 CGPQAHLPHCRGCSQNGQTYG--------NGETFSP----------------DACTT-CR 160

Query: 654 CLCNALAHYAYLCGQHGVPIDFRTQISFCAVVC--QKGMLYHHCSSFCLHS-----CISL 706
           CL  A+      C +    ++  T    C  +C  + G  + H   +         C  L
Sbjct: 161 CLTGAVQCQGPSCSELNC-LESCTPPGECCPICCTEGGSHWEHGQEWTTPGDPCRICRCL 219

Query: 707 SSPEQCSD-DCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPT--PSGLC 763
               QC   +CA  C  P           C P+    C   G  ++ GE + +  P   C
Sbjct: 220 EGHIQCRQRECASLCPYPA----RPLPGTCCPVCD-GCFLNGREHRSGEPVGSGDPCSHC 274

Query: 764 QCSNGTVKCDELATPSAV---------HICP--EGKEYFDCRFPDPE------------- 799
           +C+NG+V+C+ L  P              CP  +G EY   ++   E             
Sbjct: 275 RCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRC 334

Query: 800 -LPAGGVNCE------TTCANLAMNFTCTPS------------------SPCISGCVCAP 834
              AG V+CE      T CA  A      P+                   PC + CVC  
Sbjct: 335 SCQAGEVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPC-TACVCQD 393

Query: 835 GVCRRGMFNCTYYPC 849
           GV + G   C   PC
Sbjct: 394 GVPKCGAVLCPPAPC 408



 Score = 38.9 bits (89), Expect = 0.058
 Identities = 39/134 (29%), Positives = 46/134 (34%), Gaps = 16/134 (11%)

Query: 722 CPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSG---LCQCSNGTVKCDELATP 778
           CP           C P     C + G  Y  G   P PS    LC+C +G V+C  LA  
Sbjct: 521 CPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQC--LARR 578

Query: 779 SAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLA--MNFTCTPSSPCISGCVCAPGV 836
                CPE         P    PAG   C    A  A    +   P  PC   C+C    
Sbjct: 579 CVPLPCPEPVLLPGECCPQCPAPAG---CPRPGAAHARHQEYFSPPGDPC-RRCLCLD-- 632

Query: 837 CRRGMFNCTYYPCP 850
              G  +C   PCP
Sbjct: 633 ---GSVSCQRLPCP 643



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 31/136 (22%), Positives = 46/136 (33%), Gaps = 20/136 (14%)

Query: 291 CKTDDDETYC--RAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTC 348
           C   D   +C  +A   + R CS  G   Q + +      D C         + C  P+C
Sbjct: 117 CVCQDGAAHCGPQAHLPHCRGCSQNG---QTYGNGETFSPDACTTCRCLTGAVQCQGPSC 173

Query: 349 TFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVC 408
                   S L+CL+ C  P       G C  +     G H       +     C  C C
Sbjct: 174 --------SELNCLESCTPP-------GECCPICCTEGGSHWEHGQEWTTPGDPCRICRC 218

Query: 409 VGGVWNCTEQDCPVQC 424
           + G   C +++C   C
Sbjct: 219 LEGHIQCRQRECASLC 234



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 73/331 (22%), Positives = 106/331 (32%), Gaps = 77/331 (23%)

Query: 1696 PDYCSLS-CPEG------KEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILH 1748
            PD C+   C +G      + + P  R C        +  G T   +    C C  G +  
Sbjct: 111  PDACTACVCQDGAAHCGPQAHLPHCRGCSQNG--QTYGNGETFSPDACTTCRCLTGAVQC 168

Query: 1749 RPHSAQ-------CIPEKECA--CTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIE 1799
            +  S         C P  EC   C          G+ W    D C + +CLE G I   +
Sbjct: 169  QGPSCSELNCLESCTPPGECCPICCTEGGSHWEHGQEWTTPGDPCRICRCLE-GHIQCRQ 227

Query: 1800 PDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVC-GCDTTLCETSIPTCTNSQKLIVGHSP 1858
             +C      +C   A  + G     TCC   VC GC     E        S + +    P
Sbjct: 228  REC----ASLCPYPARPLPG-----TCCP--VCDGCFLNGREH------RSGEPVGSGDP 270

Query: 1859 LS-C-CPQYKCECDPLKCPSI-----------STPEC-----------REDQFMIQVR-- 1892
             S C C     +C+PL CP +             P C            ++ F +Q R  
Sbjct: 271  CSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGL 330

Query: 1893 -------------QEEPCCFSPFCVCESCTKPVPLCH-DGEFLTVDLNSTHFCCPQYYCV 1938
                         +E+ C  +P  +  S  +  P C  DGE     +       P   CV
Sbjct: 331  CVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACV 390

Query: 1939 CEPNLCPMPLLNCAEDMNLVKENVSGQCCPT 1969
            C+  +     + C            G CCP+
Sbjct: 391  CQDGVPKCGAVLCPPAPCQHPTQPPGACCPS 421



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 34/145 (23%), Positives = 49/145 (33%), Gaps = 21/145 (14%)

Query: 290 LCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFV----HRDCISCCP 345
           +C+  +    CR   E A  C +   P+         C   CD  F+    HR       
Sbjct: 215 ICRCLEGHIQCRQR-ECASLCPYPARPLPG------TCCPVCDGCFLNGREHRSGEPVGS 267

Query: 346 PTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCP----CGFHGLAYSVGSKIEQ 401
                  +C   ++ C +   CP       G  I  + CP    C + G  Y        
Sbjct: 268 GDPCSHCRCANGSVQC-EPLPCPPVPCRHPGK-IPGQCCPVCDGCEYQGHQYQSQETFRL 325

Query: 402 E----CTECVCVGGVWNCTEQDCPV 422
           +    C  C C  G  +C EQ+CPV
Sbjct: 326 QERGLCVRCSCQAGEVSCEEQECPV 350



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 27/106 (25%), Positives = 33/106 (31%), Gaps = 25/106 (23%)

Query: 320 WRDDFPACTD-KCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTC 378
           W  D   CT   C D       + C P  C    Q          G  CP        +C
Sbjct: 379 WEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQP--------PGACCP--------SC 422

Query: 379 ISLENCPCGFHGLAYSVGSKI---EQECTECVCVGGVWNCTEQDCP 421
            S     C +H   Y+ G      +  C  C C  G   C+  DCP
Sbjct: 423 DS-----CTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCP 463



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 54/225 (24%), Positives = 73/225 (32%), Gaps = 40/225 (17%)

Query: 1688 DICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTIL 1747
            D C Q    ++       G+ +QP   PCE   C  Q   G  S    R  C   VG   
Sbjct: 946  DCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQ-PEGPPSLRCHRRQCPSLVGC-- 1002

Query: 1748 HRPHSAQCIPEKECACTDSEDQPRTAGEIWNGG----IDECTLYKCLENGSIIPIEPDCD 1803
              P S    P  +  C    +      E   G      D C   +C ++ + + I   C 
Sbjct: 1003 --PPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQC-QDLTWLCIHQACP 1059

Query: 1804 EEPTPVCEREA---------------------EVVMGIIDKWT--CCSKEVCGCDTTLCE 1840
            E   P+ ER                       EV  G  ++WT   C+   C   T  C+
Sbjct: 1060 ELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREVASG--ERWTVDTCTSCSCMAGTVRCQ 1117

Query: 1841 TS--IPTCTNSQKLIVGHSPLSCCPQYKCECDPLKCPSISTPECR 1883
            +    P      K     SP SCCP  +C   P  C +   P  R
Sbjct: 1118 SQRCSPLSCGPDK-APALSPGSCCP--RCLPRPASCMAFGDPHYR 1159



 Score = 32.0 bits (71), Expect = 7.0
 Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 27/131 (20%)

Query: 308 RACSHAGYPIQDWRDDFPACTDKCD---DSFVHRDCISCCPPTCTFEKQCLGSNLHC--- 361
           +AC+ A  P     D  P C D C+   +S++           C     CLG  + C   
Sbjct: 697 KACAPALCPFPARGDCCPDC-DGCEYLGESYLSNQEFPDPREPCNL-CTCLGGFVTCGRR 754

Query: 362 ---LDGCYCPDGLVMDNGTCISLENCP----CGFHGLAYSVGSKI----EQECTECVCVG 410
                GC  P   ++ +G C     CP    C +HG+  + G  +    +  C+ C C  
Sbjct: 755 PCEPPGCSHP---LIPSGHC-----CPTCQGCRYHGVTTASGETLPDPLDPTCSLCTCQE 806

Query: 411 GVWNCTEQDCP 421
           G   C ++ CP
Sbjct: 807 GSMRCQKKPCP 817


>gi|239757284 PREDICTED: similar to Fc fragment of IgG binding protein
            [Homo sapiens]
          Length = 593

 Score =  142 bits (359), Expect = 3e-33
 Identities = 127/533 (23%), Positives = 215/533 (40%), Gaps = 54/533 (10%)

Query: 524  ILLKTTFGLKILFAIDGERIYIQLT--SAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTP 581
            ++++T FGL++ + +     Y+++T    + ++  GLCG +NG+ +DDF  P+G   G  
Sbjct: 21   VVIETDFGLRVAYDLV---YYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGSQAGNA 77

Query: 582  QLHANAWRV---SSTCFAPVHVPVVDPCNIN--------QQNIGYAAHCDVIHQEL--FA 628
                N+W      S C  P   P      I         ++       C ++       +
Sbjct: 78   NEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPLS 137

Query: 629  PCHIYISPGLYYQLCRHDACKCGS--SCLCNALAHYAYLCGQHGVPID-FRTQISFCAVV 685
             CH  + P    + C  D C  G   S LC+ +  Y   C   G  ++ +RT+ +FC + 
Sbjct: 138  SCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTE-TFCPME 196

Query: 686  CQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHY 745
            C     Y  C+  C   C +LS+P QC D CAEGC C  G  Y      CVPI  C C++
Sbjct: 197  CPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNG--QACVPIQQCGCYH 254

Query: 746  RGSVYQPGE--LIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDC--RFPDPELP 801
             G  Y+P +  LI      C C  G V   +  +     +C        C  +     L 
Sbjct: 255  NGVYYEPEQTVLIDNCRQQCTCHAGKVVVCQEHSCKPGQVCQPSGGILSCVTKVTLRSLA 314

Query: 802  AGGVNCETTC-----ANLAMNFTCTPSSPCISGCVCAP-GVCR-RGMFNCTYYPCPAVCT 854
              GV+ E          L +        PC  G  C P   C+ +G          A C 
Sbjct: 315  QTGVDVEGAAILYNGQPLKVLLPLLSPDPC-HGVTCRPQETCKEQGGQGVCLPNYEATCW 373

Query: 855  IYGDRHYYSFDGLEYDYISDCQVFL-------IKSADDSDISVIAQNKKCFDNDIVCSKS 907
            ++GD HY+SFDG ++D+   C   L       + +   +  +V  +N+   +  +   + 
Sbjct: 374  LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRV 433

Query: 908  VLISVGDTEIYLN-DTPYKQKQSGFF-------LENKSTYQLWKAGYYIVVYFPEKDITI 959
            V ++   T I ++ D   K + +G          + + +     +   +V  F    + +
Sbjct: 434  VTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADF---GLQV 490

Query: 960  LWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSW 1012
             +D    + + +   +   + GLCGN D+  +ND    N     +  ++G SW
Sbjct: 491  SYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSW 543



 Score =  107 bits (267), Expect = 1e-22
 Identities = 76/287 (26%), Positives = 116/287 (40%), Gaps = 26/287 (9%)

Query: 153 GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIIL 212
           GQI   +    ++++T FG  +A+D +  + + +  ++  + CGLCGNYN    DDF   
Sbjct: 10  GQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKP 69

Query: 213 QEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGM----------PAFEAIFFK- 261
                 +   F NSW    PD      +P   P PC  G           P  E  + K 
Sbjct: 70  NGSQAGNANEFGNSWEEVVPD------SPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKE 123

Query: 262 --CQILLQ--FPFLSCHEYIDPYLYIASCVNDLCKTDDD-ETYCRAATEYARACSHAGYP 316
             C +L     P  SCH+ +DP   +  C+ DLC    +    C     Y  AC  AG  
Sbjct: 124 EFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGH 183

Query: 317 IQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNG 376
           ++ WR +   C  +C  +  +  C   C   C+           C +GC C  G + +  
Sbjct: 184 VEPWRTE-TFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNGQ 242

Query: 377 TCISLENCPCGFHGLAYSVGSK--IEQECTECVC-VGGVWNCTEQDC 420
            C+ ++ C C  +G+ Y       I+    +C C  G V  C E  C
Sbjct: 243 ACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKVVVCQEHSC 289



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 50/179 (27%), Positives = 79/179 (44%), Gaps = 18/179 (10%)

Query: 949  VVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVF 1008
            VV   +  + + +D    + + V   +  ++ GLCGN++    +D    N  +  NA  F
Sbjct: 21   VVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGSQAGNANEF 80

Query: 1009 GDSWALGQCESPDETIKPCE------AHQNKFP------YAKKE-CSILYSDI--FASCR 1053
            G+SW     +SP     PC          +K P      Y K+E C +L S     +SC 
Sbjct: 81   GNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCH 140

Query: 1054 NVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIH-WRSSTVCSLDC 1111
             ++D     K+C  D C    GG+   LC++I AY   C   G  +  WR+ T C ++C
Sbjct: 141  KLVDPQGPLKDCIFDLCLG--GGNLSILCSNIHAYVSACQAAGGHVEPWRTETFCPMEC 197



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 54/210 (25%), Positives = 90/210 (42%), Gaps = 21/210 (10%)

Query: 28  NGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCS 87
           +G  C    TC  Q     G +   +PN     +  C  WG  H+ +FDG  + F G C+
Sbjct: 345 HGVTCRPQETCKEQ-----GGQGVCLPNY----EATCWLWGDPHYHSFDGRKFDFQGTCN 395

Query: 88  YIFAKD-CGDLEPR----YTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKK- 141
           Y+ A   C  +  +    +TV   N  +  G+    Y  +    +    I I+  EI K 
Sbjct: 396 YVLATTGCPGVSTQGLTPFTVTTKNQNR--GNPAVSYVRVVTVAALGTNISIHKDEIGKV 453

Query: 142 --NGISLTLPQTI--GQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGL 197
             NG+   LP ++  G+I + + A   L+   FG  +++D    + + L   + G  CGL
Sbjct: 454 RVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGL 513

Query: 198 CGNYNDIQSDDFIILQEDYTEDIAMFANSW 227
           CGN +   ++D +         I ++  SW
Sbjct: 514 CGNMDRNPNNDQVFPNGTLAPSIPIWGGSW 543



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 62/271 (22%), Positives = 101/271 (37%), Gaps = 53/271 (19%)

Query: 1525 VPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL-SSYTEGLCGIC 1583
            +P+  ++ ++     GS  VI T  GL + +       D+ +  R  +  +Y + +CG+C
Sbjct: 3    LPVVLANGQIRASQHGSDVVIETDFGLRVAY-------DLVYYVRVTVPGNYYQQMCGLC 55

Query: 1584 ---NEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCT-----EHDC- 1634
               N DP DD +  NG+   N  + G    SWE     EV    P    T       DC 
Sbjct: 56   GNYNGDPKDDFQKPNGSQAGNANEFG---NSWE-----EVVPDSPCLPPTPCPPGSEDCI 107

Query: 1635 --SQCIDLLNRRI---------------FIPCHDKVSPEDFCEKMWINYTYFW---NYEC 1674
               +C   L ++                   CH  V P+   +    +        +  C
Sbjct: 108  PSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILC 167

Query: 1675 DALSAYVALCNKFDICIQ-WRTPDYCSLSCPEGKEYQPCVRPCE-ARTCLNQWFYGHTSC 1732
              + AYV+ C      ++ WRT  +C + CP    Y+ C   C    + L+        C
Sbjct: 168  SNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGC 227

Query: 1733 LNLREDCVCKVGTILHRPHSAQCIPEKECAC 1763
                E C C  G +    +   C+P ++C C
Sbjct: 228  ---AEGCQCDSGFLY---NGQACVPIQQCGC 252



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 44/180 (24%), Positives = 80/180 (44%), Gaps = 21/180 (11%)

Query: 424 CSVVGDSHFTTFDGRHYSFIGMCQYIL-------VKGTGKDKFTITLQKAPCEQNLGLVC 476
           C + GD H+ +FDGR + F G C Y+L       V   G   FT+T +     QN G   
Sbjct: 372 CWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTK----NQNRGNPA 427

Query: 477 LQSITLILEDDFNKQVTLG-------RGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTT 529
           +  + ++        +++        R   +LT+       +G + + T  +   LL   
Sbjct: 428 VSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSV-ADGRISV-TQGASKALLVAD 485

Query: 530 FGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWR 589
           FGL++ +  +  R+ + L S++     GLCG  + N  +D + P+G +  +  +   +WR
Sbjct: 486 FGLQVSYDWNW-RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWR 544



 Score = 32.0 bits (71), Expect = 7.0
 Identities = 42/191 (21%), Positives = 74/191 (38%), Gaps = 33/191 (17%)

Query: 1425 QVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRI--PG-------EII 1475
            Q    +C P +E  C   +  +    +FDG         +Y+L     PG          
Sbjct: 358  QGGQGVCLPNYEATCW--LWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFT 415

Query: 1476 VAHIEKCSMNQAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQE-- 1533
            V    +   N A S  +  +    L     IHK  +     KV V+ ++  LP S  +  
Sbjct: 416  VTTKNQNRGNPAVS-YVRVVTVAALGTNISIHKDEIG----KVRVNGVLTALPVSVADGR 470

Query: 1534 LSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNL---SSYTEGLCGIC---NEDP 1587
            +S+    S  ++    GL + +          + +R ++   SSY   +CG+C   + +P
Sbjct: 471  ISVTQGASKALLVADFGLQVSYD---------WNWRVDVTLPSSYHGAVCGLCGNMDRNP 521

Query: 1588 DDDLRMQNGTI 1598
            ++D    NGT+
Sbjct: 522  NNDQVFPNGTL 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.472 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,494,802
Number of Sequences: 37866
Number of extensions: 5428814
Number of successful extensions: 14241
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 10220
Number of HSP's gapped (non-prelim): 2163
length of query: 2250
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2132
effective length of database: 13,779,330
effective search space: 29377531560
effective search space used: 29377531560
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.