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Search of human proteins with 117935038
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117935038 cylicin, basic protein of sperm head cytoskeleton
1 [Homo sapiens]
(651 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 1311 0.0
gi|4557509 cylicin 2 [Homo sapiens] 178 1e-44
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 120 5e-27
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 103 5e-22
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 98 2e-20
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 98 2e-20
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 97 5e-20
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 97 5e-20
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 97 5e-20
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 94 4e-19
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 94 4e-19
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 94 4e-19
gi|104526627 triadin [Homo sapiens] 93 7e-19
gi|62244004 modulator of estrogen induced transcription isoform ... 89 1e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 89 1e-17
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 89 2e-17
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 89 2e-17
gi|63176611 modulator of estrogen induced transcription isoform ... 89 2e-17
gi|87299628 biorientation of chromosomes in cell division 1-like... 87 5e-17
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 85 2e-16
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 84 5e-16
gi|20070262 TNF receptor-associated factor 3 interacting protein... 83 9e-16
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 82 2e-15
gi|125656165 THO complex 2 [Homo sapiens] 82 2e-15
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 81 3e-15
gi|213385278 TNF receptor-associated factor 3 interacting protei... 81 3e-15
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 81 3e-15
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 81 3e-15
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ... 80 6e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 79 2e-14
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 1311 bits (3394), Expect = 0.0
Identities = 651/651 (100%), Positives = 651/651 (100%)
Query: 1 MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTR 60
MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTR
Sbjct: 1 MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTR 60
Query: 61 HDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKD 120
HDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKD
Sbjct: 61 HDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKD 120
Query: 121 EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSE 180
EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSE
Sbjct: 121 EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSE 180
Query: 181 TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE 240
TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE
Sbjct: 181 TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE 240
Query: 241 NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES 300
NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES
Sbjct: 241 NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES 300
Query: 301 EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKK 360
EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKK
Sbjct: 301 EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKK 360
Query: 361 KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQK 420
KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQK
Sbjct: 361 KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQK 420
Query: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN
Sbjct: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
Query: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG
Sbjct: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
Query: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV 600
SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV
Sbjct: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV 600
Query: 601 PPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL 651
PPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL
Sbjct: 601 PPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL 651
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 178 bits (452), Expect = 1e-44
Identities = 136/406 (33%), Positives = 200/406 (49%), Gaps = 65/406 (16%)
Query: 1 MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQI---T 57
MSLPR +VN YDN IP+SE S+KSWNQ+HFAL FPKP + GT +S+P SQI T
Sbjct: 1 MSLPRFQRVNFGPYDNYIPVSELSKKSWNQQHFALLFPKPQRPGTKRRSKP--SQIRDNT 58
Query: 58 VTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKK 117
V+ D+ +L G + W+ S +I + P +Y AAR Q P + T + K AE K
Sbjct: 59 VSIIDEEQL-RGDRRQPLWMYRSLMRISERPSVYLAARRQ-PLKPTRTVEVDSKAAEIGK 116
Query: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
++K DS+ + + + + +E+ + + +A K K + E+ K S +
Sbjct: 117 KGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSAT 176
Query: 178 SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEI 237
ES++ K +K ++KDKKDS K + TE K +KD K+ K +
Sbjct: 177 ------ESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSK----- 225
Query: 238 CSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSD 297
+ D +I A K D KK+ D
Sbjct: 226 ---------------KGKDSAIELQA--------------------VKADEKKDEDGKKD 250
Query: 298 A-ESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKK 356
A + ++SKDAKKD+K++KK K DKKK D++S D D +K++KKD K K
Sbjct: 251 ANKGDESKDAKKDAKEIKKG--KKDKKKPSSTDSDSKD-------DVKKESKKDATKDAK 301
Query: 357 DDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK 402
KKDT+K ES D++ K+A+ D++ K + D+KKDAKK
Sbjct: 302 KVAKKDTEK--ESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKK 345
Score = 122 bits (306), Expect = 1e-27
Identities = 100/251 (39%), Positives = 132/251 (52%), Gaps = 42/251 (16%)
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTES--TDAESG---- 338
K + K K ++D+ESE K KKDSKK K K ++K D KKD++ DAE G
Sbjct: 117 KGEDKTTQKDTTDSESE-LKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSA 175
Query: 339 -DSKDERKDTKKDKKKLKKDDKK-KDTKKYPESTDTESGDAKDARNDSRNLKK------- 389
+S+DE+ KKD KK KKD K KD+ ES + G KD++ ++ KK
Sbjct: 176 TESEDEKGGAKKDNKKDKKDSNKGKDSAT--ESEGEKGGTEKDSKKGKKDSKKGKDSAIE 233
Query: 390 --ASKNDDKK-KDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA 446
A K D+KK +D KK D+ ESK+++KD K+ KK K K S + + D
Sbjct: 234 LQAVKADEKKDEDGKK-----DANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDV 288
Query: 447 DSEPKGDSKKGKKDEKKGKKDSKKD--DKKKDAKKNAESTEMESDLELKKDKKHSKEKKG 504
E K D+ K K K KKD++K+ D KKDAKKNA KKD K KK
Sbjct: 289 KKESKKDATKDAK--KVAKKDTEKESADSKKDAKKNA-----------KKDAK-KDAKKN 334
Query: 505 SKKDIKKDARK 515
+KKD KKDA+K
Sbjct: 335 AKKDEKKDAKK 345
Score = 122 bits (305), Expect = 1e-27
Identities = 103/284 (36%), Positives = 136/284 (47%), Gaps = 57/284 (20%)
Query: 306 AKKDSKKVKKNVKKDDKKKDVKKDTE--STDAESGDSKDERKDTKKDKKKLKKDDKKKDT 363
A++ K + V+ D K ++ K E +T ++ DS+ E K KKD KK K +K K+
Sbjct: 94 ARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEE 153
Query: 364 KKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEK 423
K DA+ DS KK K+ +K KD+ +ESE E ++KD K
Sbjct: 154 KL-------------DAKKDS---KKGKKDAEKGKDSA-------TESEDEKGGAKKDNK 190
Query: 424 KDKKDSKTDNKKSVKNDEESTDADSEPKG---DSKKGKKDEKKGKK----------DSKK 470
KDKKDS K + +T+++ E G DSKKGKKD KKGK D KK
Sbjct: 191 KDKKDSN-------KGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKK 243
Query: 471 D-DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529
D D KKDA K ES K KK +KE K KKD KK + D++S D ES K
Sbjct: 244 DEDGKKDANKGDES---------KDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKK 294
Query: 530 TGFKTSTKIKGSDTESEESLYKPGAKK--KIDESDGTSANSKME 571
K + K+ DTE E + K AKK K D N+K +
Sbjct: 295 DATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKD 338
Score = 116 bits (290), Expect = 7e-26
Identities = 86/240 (35%), Positives = 127/240 (52%), Gaps = 31/240 (12%)
Query: 257 ESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN 316
++ + ++ L+ +++ K ++ K K D KK++KK ++E KD+ +S+ K
Sbjct: 126 DTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGK-KDAEKGKDSATESEDEKGG 184
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK------------KKDTK 364
KKD+KK KKD+ + +S+ E+ T+KD KK KKD K K D K
Sbjct: 185 AKKDNKKD--KKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEK 242
Query: 365 KYPE-STDTESGD-AKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE 422
K + D GD +KDA+ D++ +KK K DKKK + STDS+S+ + K
Sbjct: 243 KDEDGKKDANKGDESKDAKKDAKEIKKGKK--DKKKPS-----STDSDSKDDVK------ 289
Query: 423 KKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE 482
K+ KKD+ D KK K D E ADS+ K K KKD KK K + K D+KKDAKK +
Sbjct: 290 KESKKDATKDAKKVAKKDTEKESADSK-KDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK 348
Score = 92.8 bits (229), Expect = 9e-19
Identities = 77/250 (30%), Positives = 122/250 (48%), Gaps = 37/250 (14%)
Query: 383 DSRNLKKASKNDDK--KKDAKKITFSTDSESELESKESQKDEKK---------DKKDSKT 431
DS+ + K +DK +KD +TDSESEL K+ +KD KK +K D+K
Sbjct: 108 DSKAAEIGKKGEDKTTQKD------TTDSESEL--KQGKKDSKKGKDIEKGKEEKLDAKK 159
Query: 432 DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLE 491
D+KK K+ E+ D+ +E + + KKD KK KKDS K KD+ +E + ++ +
Sbjct: 160 DSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKG---KDSATESEGEKGGTEKD 216
Query: 492 LKKDKKHSKEKKGS-------------KKDIKKDARKDTESTDAEFD-ESSKTGFKTSTK 537
KK KK SK+ K S +D KKDA K ES DA+ D + K G K K
Sbjct: 217 SKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKK 276
Query: 538 IKGSDTESEESLYKPGAKKKI-DESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
+D++S++ + K K D +++ E +SK+ + ++KK + + A
Sbjct: 277 PSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAK 336
Query: 597 TGRVPPSREK 606
+++K
Sbjct: 337 KDEKKDAKKK 346
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 117 KSKD-EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKS 175
+SKD +K +KK K K +T+ +SK V++++K+ D + ++S S
Sbjct: 256 ESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADS 315
Query: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKK 208
K ++ N + K KN + +KKD+K K
Sbjct: 316 KKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK 348
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 120 bits (300), Expect = 5e-27
Identities = 99/497 (19%), Positives = 183/497 (36%), Gaps = 18/497 (3%)
Query: 117 KSKDEKGGTPLK--KDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKK 174
+SKD G+ K +D S N +S +++D KS + S
Sbjct: 497 ESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSD 556
Query: 175 SKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP----KKDLKRSKTS 230
S +SS+++ S + + S + S D DS +S ++++ + N+ D S S
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 231 NDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK 290
+D + D +SD N N ++S N S D+
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKD 350
++ S + S DS D+ S + + D D ++S+++ S DS D
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736
Query: 351 KKKLKKDDKKKDTKKYPESTD----TESGDAKDARNDSRNLKKASKNDDKKKDAKKITFS 406
D+ +S+D + S D+ D+ +DS + +S + D + S
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 407 TDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTD----ADSEPKGDSKKGKKDEK 462
S S S S + D DS + N N +S+D +DS DS G +
Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855
Query: 463 KGKKDSKKDDKKKDAKKNAESTEM--ESDLELKKDKKHSKEKKGSKKDIKKDARKDTEST 520
+ DS D+ ++ S++ SD + S + S D+ ++S+
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Query: 521 DAEFDESSKTGFKTSTKIKGSD-TESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGF 579
D+ S +S SD + S +S + D S+ + +++ + +S
Sbjct: 916 DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975
Query: 580 RMSSKKTTFNEKGEKAS 596
S ++ + +S
Sbjct: 976 SSDSSNSSDSSDSSDSS 992
Score = 119 bits (299), Expect = 7e-27
Identities = 97/470 (20%), Positives = 178/470 (37%), Gaps = 24/470 (5%)
Query: 113 AEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQS 172
++ S D DS S ++N + + + +D + KS +S
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES 631
Query: 173 KKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSND 232
S S S+++ NS S N D +S NS ++ + ++ D S S+D
Sbjct: 632 DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 233 PI-SEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKN 291
S SE+S + D D S + D+ N S ++S N S D+ +
Sbjct: 692 SSDSSNSSESSDSSD-----SSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS 746
Query: 292 AKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDT-KKD 350
+ S+ ++S DS D+ S D S + S DS D + D
Sbjct: 747 SDSSNSSDSSDSSDSSNSS----------DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Query: 351 KKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
D+ +S+D++S ++ D+ N S + S N D+ + +DS+
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS--SDSSNSSDSSDSSDSSDGSDSD 854
Query: 411 SELESKESQKDEKKDKKDS--KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS 468
S S S + D DS +D+ S ++E S +DS +S + DS
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 469 KKDDKKKDAKKNAESTE--MESDLELKKDKKHSKEKKGSK-KDIKKDARKDTESTDAEFD 525
D+ +++ S++ SD D S + S D+ ++S+D+
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974
Query: 526 ESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
+SS + + + ++S +S + D SD + +++ + S
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Score = 113 bits (282), Expect = 6e-25
Identities = 93/476 (19%), Positives = 173/476 (36%), Gaps = 13/476 (2%)
Query: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSK 189
DS S ++ S + N +D + SS+ ++ S S SS ++ +S N
Sbjct: 802 DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD--SSNSSDSSDSSDSSDGSDSDSSNRS 859
Query: 190 TVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM 249
S + D DS NS ++ +++ D S S+D S S +S + D
Sbjct: 860 DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 250 LVGQSD-----DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSK 304
S+ D S + D+ N S ++ + S + + N+ SSD+ S DS
Sbjct: 920 SSDSSESSNSSDNSNSSDS--SNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 305 DAKKDSKKVKKNVKKDDK-KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDT 363
D+ S + D D ++S+D+ D+ D +
Sbjct: 978 DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Query: 364 KKYPESTDTESGDAKDARN--DSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKD 421
S ++S D+ D+ N DS + +S + D + S S+S S S
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097
Query: 422 EKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNA 481
+ D DS + S +D + S+ S + DS + D+ ++
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157
Query: 482 ESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGS 541
+S++ + S S D+ ++S+D+ S +S S
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1217
Query: 542 D-TESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
D ++S +S + + D SD + ++ +S S + N++ + S
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQS 1273
Score = 112 bits (280), Expect = 1e-24
Identities = 88/474 (18%), Positives = 175/474 (36%), Gaps = 22/474 (4%)
Query: 112 KAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQ 171
K++ KS+ + + K DS S +++ + + +D + S +
Sbjct: 623 KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD 682
Query: 172 SKKSKSSSETNPESQNSKTV-SKNCSQKDKKDSKNSKKTNTEFLHTKN--------NPKK 222
S S SS+++ S +S++ S + S D DS +S +N+ + N N
Sbjct: 683 SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD 742
Query: 223 DLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTK 282
S +SN S S++S + D SD + + + S ++ + S +
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802
Query: 283 YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKD 342
+ ++ SSD++S +S D+ S D S ++S D D
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSS----------DSSDSSNSSDSSDSSDSSDGSD 852
Query: 343 ERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK 402
+ D D+ +S+D S D+ ++ N S + ++ +D D+
Sbjct: 853 SDSSNRSDSSNSSDSSDSSDSSNSSDSSD--SSDSNESSNSSDSSDSSNSSDSDSSDSSN 910
Query: 403 ITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEK 462
+ S+DS + +S ES +++ S + + S +DS DS
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 463 KGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA 522
DS D+ +++S++ + S S D+ ++S+++
Sbjct: 971 SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030
Query: 523 EFDESSKTGFKTSTKIKGSD-TESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
S +S SD ++S S + D SD + ++ + ES
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Score = 111 bits (278), Expect = 2e-24
Identities = 98/456 (21%), Positives = 174/456 (38%), Gaps = 20/456 (4%)
Query: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSK 189
DS S ++ S + + R + ++ + S ++ S S SS++N S +S
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 190 TV-SKNCSQKDKKDSKNSK----KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLN 244
+ S N S D DS NS +N+ +N + S +SN S S++S +
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 245 VDFLMLVGQSDDESINFDAWLRNYSQNN-SKNYSLKYTKYTKKDTKKNAKKSSDAESEDS 303
D S D S + D+ N S ++ S N S D+ ++ S+ ++S DS
Sbjct: 954 SDS----SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1009
Query: 304 KDAKKDSKKVKKNVKKDDKKKDVKKDT-ESTDAESGDSKDERKDTKKDKKKLKKDDKKKD 362
D+ S + D D+ +S+D+ + D+ D
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069
Query: 363 TKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE 422
+ S ++S ++ D+ +DS N +S + D + S S+S S S +
Sbjct: 1070 SDSSDSSDSSDSSESSDS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 423 KKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE 482
D DS + S +D + S+ S + DS D+ +++
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 483 STEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD 542
S++ SD D S + S D+ ++S+D+ S ++S SD
Sbjct: 1189 SSD-SSDSSDSSDSSDSSDSSDSS-----DSSDSSDSSDSSDSSDSSDSNESSDSSDSSD 1242
Query: 543 TESEESLYKPGAKKKIDESDGTSANSKMEGLESKRG 578
S +S + D SD TS ++ +SK G
Sbjct: 1243 --SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSG 1276
Score = 110 bits (274), Expect = 5e-24
Identities = 92/470 (19%), Positives = 167/470 (35%), Gaps = 20/470 (4%)
Query: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSK 189
DS S ++N + + N +D + S + S S S +N +
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDS 870
Query: 190 TVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM 249
+ S N S N +++ + N+ D S S+D S +S N
Sbjct: 871 SDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSD------SSDSSNSSDSS 924
Query: 250 LVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKD 309
S D S + D+ N S ++ + S + + N+ SSD+ S DS D+
Sbjct: 925 ESSNSSDNSNSSDS--SNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS 982
Query: 310 SKKVKKNVKKDDK-KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPE 368
S + D D ++S+D+ D+ D +
Sbjct: 983 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042
Query: 369 STDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKD 428
S ++S D+ D+ N S + + +D D+ + S+DS +S +S
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSS--DSSDSSDSSDSSESSDSSDSSNSSDSSDSS 1100
Query: 429 SKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMES 488
+D+ S + + S +DS DS + DS D+ ++ES++ S
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSS-----DSSDSSDSSDSSNSSDSSDSSESSD-SS 1154
Query: 489 DLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD-TESEE 547
D D S + S D+ ++S+D+ S +S SD ++S +
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1212
Query: 548 SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAST 597
S + D SD + +N + +S S+ + + ST
Sbjct: 1213 SSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDST 1262
Score = 108 bits (271), Expect = 1e-23
Identities = 96/501 (19%), Positives = 181/501 (36%), Gaps = 23/501 (4%)
Query: 113 AEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQS 172
++ S D + S S +++ + N +D + +S ++ S
Sbjct: 747 SDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806
Query: 173 KKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSND 232
S SS+++ ++ + S N S D DS NS ++ + + RS +SN
Sbjct: 807 SDSSDSSDSSDSDSSNSSDSSNSS--DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNS 864
Query: 233 PISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNA 292
S S++S + D S D + + ++ + S N+S + S + + N+
Sbjct: 865 SDSSDSSDSSNSSDS----SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS 920
Query: 293 KKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKK 352
SS++ + DS + D S + S DS D D
Sbjct: 921 SDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSS 980
Query: 353 KLKKDDKKKDTKKYPESTD-------TESGDAKDARN--DSRNLKKASKNDDKKKDAKKI 403
D+ +S+D ++S D+ D+ N DS N +S + D +
Sbjct: 981 NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSS 1040
Query: 404 TFSTDSESELESKESQKDEKKDKKDS-----KTDNKKSVKNDEESTDADSEPKGDSK-KG 457
S S+S S S + D DS +D+ S + E S +DS DS
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSS 1100
Query: 458 KKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDT 517
+ DS D+ +++S++ + S S+ D+ +
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSS 1160
Query: 518 ESTDAEFDESSKTGFKTSTKIKGSD-TESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
+S+D+ S +S SD ++S +S + D SD + ++ + +S
Sbjct: 1161 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1220
Query: 577 RGFRMSSKKTTFNEKGEKAST 597
SS + NE + + +
Sbjct: 1221 DS-SDSSDSSDSNESSDSSDS 1240
Score = 108 bits (269), Expect = 2e-23
Identities = 90/461 (19%), Positives = 168/461 (36%), Gaps = 14/461 (3%)
Query: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
S D + S S +++ ++ + +D + SS ++ S + S
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724
Query: 178 SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEI 237
S+++ S +S + S + D DS NS ++ + ++ D S S+D +
Sbjct: 725 DSDSSNSSDSSDS-SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 238 CSENSLNVDFLMLVGQSDDESINFDAW-LRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSS 296
S +S N S D S + D+ + S ++S N S D+ ++ S
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843
Query: 297 DAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKK 356
++S D D+ ++ N D ++S+D S DS + +
Sbjct: 844 SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSD--SSDSNESSNSSDSSDSSNSS 901
Query: 357 DDKKKDTKKYPESTD-TESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELES 415
D D+ +S+D + S D+ ++ N S N S + D + S S S S
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDN----SNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 416 KESQKDEKKDKKDSKTDNKKSVKNDEESTD-ADSEPKGDSKKGKKDEKKGKKDSKKDDKK 474
S D DS + + N +S+D +DS DS D
Sbjct: 958 NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017
Query: 475 KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKT 534
N+ + SD D S + S D+ ++S+D+ +SS + +
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSD--SSDSSNSSDSSDS--SDSSDSSDSS 1073
Query: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
+ +ES +S + D SD + ++ + +S
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1114
Score = 107 bits (268), Expect = 3e-23
Identities = 85/421 (20%), Positives = 155/421 (36%), Gaps = 11/421 (2%)
Query: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSK 189
+S S +N S + +++D + +S ++ S S SSE++ S NS
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 190 TV--SKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
+ S + D DS NS ++ + ++ D S +S+ S S++S + D
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
S D S + D+ + ++S N S ++ ++ S ++S DS D+
Sbjct: 995 ----SDSSDSSNSSDS-SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSS 1049
Query: 308 KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYP 367
S N D ++S+D+ E D+ D +
Sbjct: 1050 DSSD--SSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSD 1107
Query: 368 ESTDTESGDAKDARN--DSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKD 425
S ++S D+ D+ N DS + +S + D + S S+S S S + D
Sbjct: 1108 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSD 1167
Query: 426 KKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
DS + S +D + S+ S + DS D+ +++S++
Sbjct: 1168 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1227
Query: 486 MESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTES 545
E S S D+ ++ST DES + GSD++S
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDS 1287
Query: 546 E 546
+
Sbjct: 1288 D 1288
Score = 104 bits (260), Expect = 2e-22
Identities = 89/461 (19%), Positives = 174/461 (37%), Gaps = 25/461 (5%)
Query: 120 DEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSS- 178
D + S S ++N + + N +D + +S +++ S S SS
Sbjct: 854 DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSD 913
Query: 179 ---SETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
S + +S S S N + D +S +S ++ + ++ D S S+D S
Sbjct: 914 SSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNS 973
Query: 236 EICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKS 295
S++S + D S D S + D+ ++S N S D+ ++ S
Sbjct: 974 SDSSDSSNSSDS----SDSSDSSDSSDS-------SDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 296 SDAESEDSKDAKKDSKKVKKNVKKDDK-KKDVKKDTESTDAESGDSKDERKDTKKDKKKL 354
+ ++S +S D+ S + D D ++S+D+ + D+
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 355 KKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELE 414
+ D + S ++S D+ D+ +DS + +S + + + S S+S
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDS-SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141
Query: 415 SKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK 474
S S E D DS + S +D + S+ S + DS
Sbjct: 1142 SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201
Query: 475 KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKT 534
D+ +++S++ SD D S + S + D+ ++S+D+ S +
Sbjct: 1202 SDSSDSSDSSD-SSDSSDSSDSSDSSDSSDSNE--SSDSSDSSDSSDSSNSSDSSDSSDS 1258
Query: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
S S+ ES+ +K ++G+ ++S EG +S
Sbjct: 1259 SDSTSDSNDESDSQ-----SKSGNGNNNGSDSDSDSEGSDS 1294
Score = 104 bits (259), Expect = 3e-22
Identities = 89/462 (19%), Positives = 170/462 (36%), Gaps = 25/462 (5%)
Query: 149 EEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK------- 201
++K+ + ++ + + + +++ S+ +SS S NS N + D K
Sbjct: 456 DDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDS 515
Query: 202 ----DSKNSKKTNTEFLHTKNNPKKDLKRSKT-SNDPISEICSENSLNVDFLMLVGQSDD 256
D+ NS +N K D + K+ S+D S S +S + D +
Sbjct: 516 DSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSN 575
Query: 257 ESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN 316
S + D+ + S ++ + S D+ ++ S ++S DS K DS K + +
Sbjct: 576 SSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS---KSDSSKSESD 632
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGD 376
D K D D+ S+D+ + ++ D + S ++S D
Sbjct: 633 SSDSDSKSD-SSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 377 AKDARNDSRNLKKASKNDDKKKDA--KKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ D+ N S + + +D D+ + S+DS+S S S D DS +
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKK 494
S +D + S+ S + DS D+ ++ S SD
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS----SDSSNSS 807
Query: 495 DKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGA 554
D S + S D+ ++S+D+ +S +S GSD++S +
Sbjct: 808 DSSDSSDSSDSDSSNSSDSSNSSDSSDS---SNSSDSSDSSDSSDGSDSDSSNRSDSSNS 864
Query: 555 KKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
D SD ++++ + +S S + N +S
Sbjct: 865 SDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906
Score = 104 bits (259), Expect = 3e-22
Identities = 79/414 (19%), Positives = 147/414 (35%), Gaps = 12/414 (2%)
Query: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
S D + + + S E N SS ++ S S S
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 178 SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEI 237
S +N ++ + S + + D DS NS ++ + ++ D S S+D
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 238 CSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSD 297
S NS + S D S + D+ ++S + S D+ ++ S
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDS----SDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069
Query: 298 AESEDSKDAKKDSKKV----KKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKK 353
++S DS D+ S+ N D ++S+D+ + ++
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1129
Query: 354 LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESEL 413
D + S +ES D+ D+ +DS + +S + D + S S+S
Sbjct: 1130 SDSSDSSDSSNSSDSSDSSESSDSSDS-SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK 473
S S + D DS + S +D + S+ S + + DS
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSN 1248
Query: 474 KKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDES 527
D+ +++S++ SD D+ S+ K G+ + D+ D+E +D+ S
Sbjct: 1249 SSDSSDSSDSSDSTSD---SNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Score = 103 bits (258), Expect = 4e-22
Identities = 87/475 (18%), Positives = 176/475 (37%), Gaps = 26/475 (5%)
Query: 113 AEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQS 172
++ S D + S+ S +++ +S + +++D + S ++ S
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 173 KKSKSSSETN--------PESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL 224
S SS+++ +S NS S + D DS NS +N + ++ D
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDS---SNSSDSSDS 797
Query: 225 KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYT 284
S S++ S +S + D S D S + D+ + S ++ + S + +
Sbjct: 798 SNSSDSSNSSDSSDSSDSSDSDS----SNSSDSSNSSDS--SDSSNSSDSSDSSDSSDGS 851
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKV-KKNVKKDDKKKDVKKDTESTDAESGDSKD- 342
D+ + S+ ++S DS D+ S + + D + S+D++S DS +
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Query: 343 -ERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAK 401
+ D+ + + ++ S ++S D+ D+ N S S N ++
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS-----DSSNSSDSSNSS 966
Query: 402 KITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDE 461
+ S S+S S S + D DS + S +D + S+ S +
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026
Query: 462 KKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTD 521
DS D+ +++S++ S S D+ +ES+D
Sbjct: 1027 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSD 1086
Query: 522 AEFDESSKTGFKTSTKIKGSD-TESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
+ +S +S SD ++S +S + D SD + ++ + S
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141
Score = 103 bits (257), Expect = 5e-22
Identities = 82/446 (18%), Positives = 170/446 (38%), Gaps = 20/446 (4%)
Query: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSK 189
DS S +++ + + + N +D + S + S S SS+++ +S NS
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSS-DSSNSS 783
Query: 190 TVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM 249
+ + + D DS NS ++ + ++ D S +S+ S S++S + D
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDS-- 841
Query: 250 LVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKD 309
S D S D+ N S +++ + S + N+ SSD S DS ++
Sbjct: 842 --SDSSDSSDGSDSDSSNRSDSSNSSDS------SDSSDSSNSSDSSD--SSDSNESSNS 891
Query: 310 SKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPES 369
S + D D ++S+D+ + E ++ + D + S
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS---NSSDSSNSSDSSDSS 948
Query: 370 TDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDS 429
+ S D+ ++ + S + + N D+ + S+DS +S +S
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 430 KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESD 489
+D+ S + + S +DS DS + DS D+ +++S++
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1066
Query: 490 LELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESL 549
+ S S+ D+ ++S+D+ +SS + + + ++S S
Sbjct: 1067 SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDS--SDSSDSSDSSDSSDSSDSSDSSNSS 1124
Query: 550 YKPGAKKKIDESDGTSANSKMEGLES 575
+ D SD ++++ + ES
Sbjct: 1125 DSSDSSDSSDSSDSSNSSDSSDSSES 1150
Score = 102 bits (254), Expect = 1e-21
Identities = 86/466 (18%), Positives = 178/466 (38%), Gaps = 18/466 (3%)
Query: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
S D + S S +++ + + + +D + +S ++ S S
Sbjct: 734 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSD 793
Query: 178 SSETNPESQNSKTV----SKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDP 233
SS+++ S +S + S + S D +S +S ++ + ++ D S +D
Sbjct: 794 SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS 853
Query: 234 ISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAK 293
S S++S + D S D S + D+ S ++ N S + + ++
Sbjct: 854 DSSNRSDSSNSSD----SSDSSDSSNSSDS-----SDSSDSNESSNSSDSSDSSNSSDSD 904
Query: 294 KSSDAESEDSKDAKKDSKKVKKNVKKDD-KKKDVKKDTESTD-AESGDSKDERKDTKKDK 351
S + S DS D+ S + + D+ D ++S+D ++S +S D +
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 352 KKLKKDDKKKDTKKYPESTD-TESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
D D+ S+D ++S D+ D+ +DS + +S + D + S S
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSNSSDSSN 1023
Query: 411 SELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKK 470
S S S + D DS + S +D ++ S+ S + DS +
Sbjct: 1024 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSE 1083
Query: 471 DDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
D+ +++S++ + S S D+ ++S+D+ +S
Sbjct: 1084 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 1143
Query: 531 GFKTSTKIKGSD-TESEESLYKPGAKKKIDESDGTSANSKMEGLES 575
+S SD ++S +S + D SD ++++ + +S
Sbjct: 1144 SSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189
Score = 102 bits (253), Expect = 1e-21
Identities = 100/523 (19%), Positives = 189/523 (36%), Gaps = 49/523 (9%)
Query: 106 SKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQ-----IVEEKTKRQNEADK 160
S+TH K + KG + ++ K+ G E K + + K Q E
Sbjct: 363 SETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN 422
Query: 161 T--PLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKN 218
P + S + S + S++N + +S Q D +S + N + +
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESD 482
Query: 219 NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSL 278
N + +S S E+ N + G DD+S + + S N N +
Sbjct: 483 N-------NSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN- 534
Query: 279 KYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESG 338
K D+ K SSD++S DS ++ S + D + D++S+D++S
Sbjct: 535 --DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSD----SSDSDSSDSNSSSDSDSSDSDSS 588
Query: 339 DSKD-------------------------ERKDTKKDKKKLKKDDKKKDTKKYPESTDTE 373
DS D + D+K D K + D D+K +S+D+
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS--DSSDSN 646
Query: 374 SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDN 433
S D+ D +DS + +S + D + S+ S+S S S + + +S +
Sbjct: 647 SSDSSD-NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS 705
Query: 434 KKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELK 493
S + +S+D+ + DS + +S D+ +++S++
Sbjct: 706 DSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
Query: 494 KDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPG 553
S S D+ + S+D+ +S +S SD+ +S
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825
Query: 554 AKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
+ D SD ++++ + +S G S + + +S
Sbjct: 826 SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS 868
Score = 100 bits (248), Expect = 5e-21
Identities = 107/514 (20%), Positives = 194/514 (37%), Gaps = 50/514 (9%)
Query: 117 KSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSK 176
KS++ G P S++ + N + VE + +++E + S + K
Sbjct: 324 KSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHA--VGKSQDKGIEIKGP 381
Query: 177 SSSETNPESQNSKTVSKNCSQKDKKDS------KNSKKTNTEFLHT-----KNNPKKDLK 225
SS N +K V K K+ K K + KT E ++ K+ P +
Sbjct: 382 SSGNRNI----TKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVG 437
Query: 226 RSKTSNDPISEICSENSLNVDFLMLVGQ---SDDESINFDAWLRNYSQNNSKNYSLKYTK 282
S T +D S+ +S + D + G S DES D N+S Y
Sbjct: 438 HSNTGSDSNSD--GYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNS 495
Query: 283 YTKKDTKKNAKKSSDAESEDSKDAK----KDSKKVKKNVKKDDKKKDVKKD-TESTDAES 337
KD N S AE +DS DS N D+ K D K ++S+D++S
Sbjct: 496 DESKDNG-NGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDS 554
Query: 338 GDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDA-------------RNDS 384
DS + + + D+ +S+D++S D+ D+ +DS
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDS----DSSDSDSSDSSDSDSSDSSNSSDSSDSSDS 610
Query: 385 RNLKKASKNDDKKKDAKKI-TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEES 443
+ +S + D K D+ K + S+DS+S+ +S +S + D DS + S +D
Sbjct: 611 SDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD 670
Query: 444 TDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK 503
+ S+ S + DS + D+ +++S +S +S +
Sbjct: 671 SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS---DSSNSNSSDSD 727
Query: 504 GSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD-TESEESLYKPGAKKKIDESD 562
S D+ ++S+D+ +S +S SD ++S +S + D +D
Sbjct: 728 SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND 787
Query: 563 GTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
++++ + S S + + +S
Sbjct: 788 SSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSS 821
Score = 96.7 bits (239), Expect = 6e-20
Identities = 109/501 (21%), Positives = 194/501 (38%), Gaps = 50/501 (9%)
Query: 112 KAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQ--NEADKTPLKSSHEN 169
K SK ++G K+D S N +SK+ + + K NE D S EN
Sbjct: 271 KDSSNNSKGQEGQDHGKEDDHDS--SIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEEN 328
Query: 170 EQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKT 229
S E N + T N + + +++ +K++ T + + ++K +
Sbjct: 329 -----SAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSS 383
Query: 230 SNDPIS-EICSENSLNVD---FLMLVGQSD----DESINFDAWLRN--------YSQNNS 273
N I+ E+ N D M++G+ + E +N + + +S S
Sbjct: 384 GNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGS 443
Query: 274 KNYSLKYTKYTKKD---------TKKNAKKSSDAESEDSK------DAKKDSKKVKKNVK 318
+ S Y Y D + + + DA SE DA +S + K N
Sbjct: 444 DSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGN 503
Query: 319 KDDKKKDVKKDTEST-DAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDA 377
D K D++ST D + DS + D K K D+ S + S D+
Sbjct: 504 GSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDS 563
Query: 378 KDAR-NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSK-TDNKK 435
D+ +DS + +S +D D+ + S S+S S S + D DS + + K
Sbjct: 564 SDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSK 623
Query: 436 SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKD 495
S + ES +DS+ K DS + DS ++ +++S++ SD D
Sbjct: 624 SDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSD-SSDSSSSSD 682
Query: 496 KKHSKEKKGSKKDIKKDARKDTESTD-AEFDESSKTGFKTSTKIKGSDTESEESLYKPGA 554
+S + S D+ +ES+D ++ +S + S+ SD++S S +
Sbjct: 683 SSNSSDSSDS-----SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDS 737
Query: 555 KKKIDESDGTSANSKMEGLES 575
D SD + +++ + +S
Sbjct: 738 SNSSDSSDSSDSSNSSDSSDS 758
Score = 79.3 bits (194), Expect = 1e-14
Identities = 92/432 (21%), Positives = 167/432 (38%), Gaps = 40/432 (9%)
Query: 156 NEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLH 215
+ +D +P S + ++ + S + + E+ N K S N ++ +D + K+ + +
Sbjct: 240 DNSDGSP--SGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQD--HGKEDDHDSSI 295
Query: 216 TKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKN 275
+N+ K+ + DP +E+ + + + D+ S + + + SK
Sbjct: 296 GQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIED-TQKLNHRESKR 354
Query: 276 YSLKYTKYTKKDTK-KNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK--------KKDV 326
+ TK ++ K+ K + + S + + K N K+DK K +V
Sbjct: 355 VENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNV 414
Query: 327 KKDTESTDAESGDSKDE------RKDTKKDKKKLKKDDKKKDTKKY----PESTDTESGD 376
K E + E K E +T D D D K P S+D +G+
Sbjct: 415 KTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGN 474
Query: 377 AKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKS 436
DA ++S N N + DA ++++D + + K + D DS +D S
Sbjct: 475 -DDANSESDN------NSSSRGDA---SYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNS 524
Query: 437 VKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDK 496
N + D K DS KGK D DS D+ +++S +S+ D
Sbjct: 525 DSNGNGNNGNDDNDKSDSGKGKSD--SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDS 582
Query: 497 KHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKK 556
S S D + S ++ +SS + + +K S +ES+ S +
Sbjct: 583 SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS----DSDS 638
Query: 557 KIDESDGTSANS 568
K D SD S++S
Sbjct: 639 KSDSSDSNSSDS 650
Score = 75.1 bits (183), Expect = 2e-13
Identities = 66/347 (19%), Positives = 131/347 (37%), Gaps = 33/347 (9%)
Query: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
S D + S S +++ + N +D + S ++ S S
Sbjct: 985 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD 1044
Query: 178 SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEI 237
SS+++ S +S + S + D DS +S ++ ++++ D S S+D
Sbjct: 1045 SSDSSDSSDSSNS-SDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Query: 238 CSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSD 297
S +S S D S + D+ + ++S + S D+ +++ S
Sbjct: 1104 DSSDS---------SDSSDSSDSSDS-SNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153
Query: 298 AESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKD 357
++S DS D+ S D ++S+D+ + + D+
Sbjct: 1154 SDSSDSSDSSDSS--------------DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1199
Query: 358 DKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKE 417
D + S ++S D+ D+ + S S + ++ D+ + S+DS + +S +
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSDSS-----DSSDSNESSDSSDSSDSSDSSNSSDSSD 1254
Query: 418 S--QKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKG-DSKKGKKDE 461
S D D D KS + +D+DS+ +G DS D+
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 60.1 bits (144), Expect = 6e-09
Identities = 72/361 (19%), Positives = 130/361 (36%), Gaps = 50/361 (13%)
Query: 286 KDTKKNAK--KSSDAESEDSKDAK----KDSKKVKKNVKKDDKKKDVKKDTESTDAES-- 337
KD+ N+K + D ED D+ DSK+ K+D +V D S E+
Sbjct: 271 KDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSA 330
Query: 338 GDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG--------DAKDARNDSRNL-K 388
G +D +D +KL + K+ + + ++T + + K + +RN+ K
Sbjct: 331 GIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITK 390
Query: 389 KASKNDDKKKDAK-------KITFSTDSESELESKESQKDEKKDK-------KDSKTDNK 434
+ K ++ K+D K T E QK E +K DS +D
Sbjct: 391 EVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGY 450
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKD-------------EKKGKKDSKKDDKKKDAKKNA 481
S D++S D D G D + D KD+ K A
Sbjct: 451 DSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGA 510
Query: 482 ESTEMESDLELKKDKKHSKEKKGSKKDIKKDARK------DTESTDAEFDESSKTGFKTS 535
E + +S + + G+ + K D+ K D++S+D+ S +
Sbjct: 511 EDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSD 570
Query: 536 TKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKA 595
+ S ++S+ S D SD ++++ + +S S + ++ +
Sbjct: 571 SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSE 630
Query: 596 S 596
S
Sbjct: 631 S 631
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/302 (21%), Positives = 112/302 (37%), Gaps = 26/302 (8%)
Query: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKD 350
N+K++ E+E + +D+ + D E D SGD +DE KD
Sbjct: 218 NSKRNGTKEAEVTPGTGEDA-----GLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKD 272
Query: 351 KKKLKKDDKKKDTKKYPESTDTESGDAKDARN--DSRNLKKASKNDDKKKDAKKITFSTD 408
K + +D K + D+ G D++ D + D K +K S
Sbjct: 273 SSNNSKGQEGQDHGK-EDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAG 331
Query: 409 SESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKD------EK 462
+ S+ + +K + ++SK + K E S+ KG KG ++
Sbjct: 332 IPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKE 391
Query: 463 KGKKDSKKDDKKKD----AKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTE 518
GK + K+DK + K N ++ ++E K K G + D+ D
Sbjct: 392 VGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVG-HSNTGSDSNSDGY 450
Query: 519 STDAEFDESSKTGF--KTSTKIKGSDTESEE----SLYKPGAKKKIDESDGTSANSKMEG 572
+ +FD+ S G +S + G+D + E S + A DES S +G
Sbjct: 451 DS-YDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKG 509
Query: 573 LE 574
E
Sbjct: 510 AE 511
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 103 bits (257), Expect = 5e-22
Identities = 138/596 (23%), Positives = 235/596 (39%), Gaps = 52/596 (8%)
Query: 57 TVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYK 116
+V+ H K K EE K K + + I E+T T + K+A+ +
Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETV--------IVEEQTEETQVTEEVTEEEE-KEAKEE 481
Query: 117 KSKDEKGGTPLK-----KDSKKKGGSYATNPE--SKQIVEEKTKRQNEA---DKTPLKSS 166
+ K+E+GG + +++K A +PE +K V+E+ K EA +K KS
Sbjct: 482 EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSP 541
Query: 167 HENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKR 226
E + +K+KS ++ +S + K + K+ +K + +P + K
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA-EAKS 600
Query: 227 SKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKK 286
+ + P+ E E + V + + + S + S + K +K
Sbjct: 601 PEKAKSPVKE---EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 287 DTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD-VKKDTESTDAESGDSKDERK 345
+ K+ +K+ ++K +K VK K +K K VK++ +S + K+E K
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 346 DTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK------KASKNDDKKKD 399
+K K +K++ K + K P + +S + + ++ L K ++ +
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 400 AKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKK 459
A K S + E K +K + K+D+K K+ K +E + E K K K+
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 460 DEKKGK--------KDSKKDDKKKD--AKKNAESTEMESDLELKKDK-KHSK--EKKGSK 506
KK + K +K D KK+ KK A ++E E +K K SK KK
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 507 KDIKKDARKDTES-TDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTS 565
+D KK + E+ E E +K KT K D + KP KK+ +
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
Query: 566 ANSKMEGLESKRGFRMSSK---KTTFNE----KGEKASTGRVPPSRE-KPPLPACE 613
K + E K +K KT E K EKA ++ KPP A E
Sbjct: 958 KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 101 bits (251), Expect = 2e-21
Identities = 113/488 (23%), Positives = 211/488 (43%), Gaps = 55/488 (11%)
Query: 94 AREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTK 153
A ++P + +K K KS EK +P+K+++K E+K V+E+ K
Sbjct: 576 AEVKSPEKAKSPAKEEAKSPAEAKSP-EKAKSPVKEEAKSPA-------EAKSPVKEEAK 627
Query: 154 RQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSK-----NCSQKDKKDSKNSKK 208
E K+P K+ ++ KS +++ PE + +K+ K K + +K+ K
Sbjct: 628 SPAEV-KSPEKAKSPTKEEAKSPEKAKS-PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685
Query: 209 TNTEFLHTKNNP-KKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRN 267
+ +P K++ K + + P+ E + ++ +++ + ++
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA---KSPVKE 742
Query: 268 YSQNNSKNYSLKYTKYTK-KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD- 325
+++ K S + K K + +A S K +K VK+ VK +K K
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 326 VKKDTESTDAESGDSKDERKDTKKDKK----KLKKDDKKKDTKKYPESTDTESGDAKDAR 381
+K+D ++ + E ++ + K+++K K+K+ KK + +K P + TE + KD++
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE--EKKDSK 860
Query: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
+ K+A K K ++ K+ ES++E+K K+E +DKK T K++ E
Sbjct: 861 KEEAPKKEAPK--PKVEEKKEPAVEKPKESKVEAK---KEEAEDKKKVPTPEKEAPAKVE 915
Query: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501
DA + K + K + D+ K K+ SK +KK+ A + KKD K K
Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE-------------KKDTKEEKA 962
Query: 502 KKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDES 561
KK +K T+A+ E KT K +K K E S + +K +
Sbjct: 963 KKPEEKP----------KTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKAT 1012
Query: 562 DGTSANSK 569
+ +A K
Sbjct: 1013 EDKAAKGK 1020
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 98.2 bits (243), Expect = 2e-20
Identities = 60/269 (22%), Positives = 136/269 (50%), Gaps = 6/269 (2%)
Query: 266 RNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK---KVKKNVKKDDK 322
R+++++ S+ + +K K K+ ++ S+D +KD++ K K+ VK+ D+
Sbjct: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
Query: 323 KKDVKKDTE-STDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381
+K+ +++ E + E G +KD K+ +KD++K K+ D++++ +K E + + + +
Sbjct: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455
Query: 382 NDSRNLKKASKNDDK-KKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKND 440
R ++ + D+K KKD K T + S+ S ++ ++ + S + + ++ K
Sbjct: 456 EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTI 515
Query: 441 EESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSK 500
+ + P+ +KK KK EK+ S++ ++++ S + + +L+K+ K
Sbjct: 516 KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK 575
Query: 501 EKKGSKKDIKKDARKDTESTDAEFDESSK 529
EK+ +K+ K+ + DA E +K
Sbjct: 576 EKEHNKEP-DSSVSKEVDDKDAPRTEENK 603
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/332 (23%), Positives = 152/332 (45%), Gaps = 45/332 (13%)
Query: 266 RNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD 325
R+ S+++SK++S + K++ K S+ +KD ++ K KK K ++
Sbjct: 313 RSKSRSSSKSHSRR---------KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE 363
Query: 326 VKKDTESTDAESGDSKDERKDTK---KDKKKLKKDDKKKDTKKYPE-STDTESGDAKDAR 381
+K + S+D+RKDT+ K+K+++K+ D++K+ ++ E + E G KD
Sbjct: 364 RRKSRSRSH-----SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD-- 416
Query: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
+ + D++KD +K D E E E KE +KD +DK+ K +K+ + +
Sbjct: 417 ------RDKEREKDREKDKEK-----DRERERE-KEHEKD--RDKEKEKEQDKEKEREKD 462
Query: 442 ESTDADSEPKGDSKK----GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKK 497
S + D + K D K + + + S ++ +++ ++ ++ S ++ K +
Sbjct: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
Query: 498 HSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKK 557
S + +KKD K++ +D S E + S TS + +D + +E L K K
Sbjct: 523 PSPRSR-NKKDKKREKERDHISERRERERS------TSMRKSSNDRDGKEKLEKNSTSLK 575
Query: 558 IDESDGTSANSKMEGLESKRGFRMSSKKTTFN 589
E + +S + ++ K R K N
Sbjct: 576 EKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607
Score = 80.9 bits (198), Expect = 3e-15
Identities = 75/351 (21%), Positives = 147/351 (41%), Gaps = 42/351 (11%)
Query: 137 SYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNS-KTVSKNC 195
S A PES + E K R SH +S+ S S SQ+ ++ S N
Sbjct: 290 SAAIEPESGKSNERKGGRSR---------SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR 340
Query: 196 SQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSD 255
S+ +KD + SK H K + ++ ++S++ + S
Sbjct: 341 SRSRQKDRRRSKSP-----HKKRSKSRERRKSRSRS---------------------HSR 374
Query: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
D+ + ++ + K+ + + +++ +K K+ D + E KD +KD +K ++
Sbjct: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 434
Query: 316 NVKKDDKKKDVKKDTEST-DAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
++ + +KD K+ E D E KD K+ + +KK KK + + Y S + S
Sbjct: 435 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK--SRTPPRSYNASRRSRS 492
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ R SR+ +S++ K K+ + + S K+ ++++++D + + +
Sbjct: 493 SSRERRRRRSRS---SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
+S + S D D + K + EK+ K+ K+ K+A TE
Sbjct: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Score = 77.0 bits (188), Expect = 5e-14
Identities = 84/376 (22%), Positives = 159/376 (42%), Gaps = 67/376 (17%)
Query: 148 VEEKTKRQNEADKTPLKS----SHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDS 203
+EE KR EA + S ++ + K +S S T +S++S SK+ S++ + S
Sbjct: 275 LEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS---SKSHSRRKRSQS 331
Query: 204 KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDA 263
K+ +++ + +KD +RSK+ +
Sbjct: 332 KHRSRSHNR----SRSRQKDRRRSKSPHKK------------------------------ 357
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAK-------KSSDAESEDSKDAKKDSKKVKKN 316
R+ S+ K+ S +++ +KDT++ K K + E E K+ +K+ ++ K
Sbjct: 358 --RSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGD 376
+ +++KD +KD E D E K+ KD +DK+K K+ DK+K+ +K S + +
Sbjct: 416 DRDKEREKDREKDKEK-DREREREKEHEKD--RDKEKEKEQDKEKEREK-DRSKEIDEKR 471
Query: 377 AKDARND----SRNLKKASKNDDKKKDAKKITFS-----TDSESELESKESQKDEKKDKK 427
KD ++ S N + S++ +++ ++ S T + +S S ++KK
Sbjct: 472 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 531
Query: 428 DSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEME 487
D K + ++ D S + E +K D +K K K+ + N E
Sbjct: 532 DKKREKER----DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587
Query: 488 SDLELKKDKKHSKEKK 503
S KD ++E K
Sbjct: 588 SKEVDDKDAPRTEENK 603
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 24/320 (7%)
Query: 306 AKKDSKKVKKNVKKDDKKKDVKKDTES---TDAESGDSKDERKDTKKDKKKLKKDDKKKD 362
A K+ ++V K V++ + ES + + G S+ + + K K+
Sbjct: 271 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 330
Query: 363 TKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE 422
+K S + KD R KK SK+ +++K + + S D + K +K+
Sbjct: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-SHSRDKRKDTREKIKEKER 389
Query: 423 KKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE 482
K+K K ++ K E+ + D ++ K EK +KD +++ +K+ K +
Sbjct: 390 VKEKDREKERERE--KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 447
Query: 483 STEMESDLELKKDKKHSKEKKGSKKDIKKD------------ARKDTESTDAEFDESSKT 530
E E D E +++K SKE +K KK +R + SS
Sbjct: 448 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507
Query: 531 GFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKR--GFRMSSKKTTF 588
+TS IK + S P ++ K D+ + E E +R R SS
Sbjct: 508 SPRTSKTIKRKSSRSP----SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 563
Query: 589 NEKGEKASTGRVPPSREKPP 608
EK EK ST K P
Sbjct: 564 KEKLEKNSTSLKEKEHNKEP 583
Score = 62.8 bits (151), Expect = 1e-09
Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 46/333 (13%)
Query: 129 KDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKS-SHENEQSKKSKSSSETNPESQN 187
K +++KGG ++ SK K+ + + ++ +S SH +S++ +P +
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358
Query: 188 SKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
SK+ + S + + S++ +K E + K K+ + + + E E N D
Sbjct: 359 SKSRERRKS-RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD- 416
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
D E ++ ++ K+ + K +KD K +K D E E KD
Sbjct: 417 ------RDKERE------KDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR- 463
Query: 308 KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERK-----------DTKKDKKKLK- 355
SK++ + KKD K + + ++ S++ R+ +K K+K
Sbjct: 464 --SKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 521
Query: 356 --------KDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKN-DDKKKDAKKITFS 406
K DKK++ ++ S E R S +++K+S + D K+K K T
Sbjct: 522 SPSPRSRNKKDKKREKERDHISERRE-------RERSTSMRKSSNDRDGKEKLEKNSTSL 574
Query: 407 TDSESELESKESQKDEKKDKKDSKTDNKKSVKN 439
+ E E S E DK +T+ K N
Sbjct: 575 KEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607
Score = 47.4 bits (111), Expect = 4e-05
Identities = 68/334 (20%), Positives = 127/334 (38%), Gaps = 36/334 (10%)
Query: 12 RTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQK 71
R+ S S S RK KH + + + R D+ R ++ +R+ +
Sbjct: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR-QKDRRRSKSPHKKRSKSRERRKSRSRS 371
Query: 72 PAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDS 131
+ + + KI + + RE+ R K K+ K +D++ +KD
Sbjct: 372 HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE--KERGKNKDRDKEREKDREKDK 429
Query: 132 KKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTV 191
+K K +EK K Q++ + S E ++ +K S T P S N+
Sbjct: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Query: 192 SKNCSQ-----------KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE 240
S++ S+ + + SK K+ ++ ++ KKD KR K D ISE
Sbjct: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK-ERDHISE---- 544
Query: 241 NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES 300
+ + S + +R S + L+ + K+ + N + S
Sbjct: 545 -----------RRERERSTS----MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589
Query: 301 E-DSKDA-KKDSKKVKKNVKKDDKKKDVKKDTES 332
E D KDA + + K++ N ++++ TE+
Sbjct: 590 EVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEA 623
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 98.2 bits (243), Expect = 2e-20
Identities = 60/269 (22%), Positives = 136/269 (50%), Gaps = 6/269 (2%)
Query: 266 RNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK---KVKKNVKKDDK 322
R+++++ S+ + +K K K+ ++ S+D +KD++ K K+ VK+ D+
Sbjct: 220 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 279
Query: 323 KKDVKKDTE-STDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381
+K+ +++ E + E G +KD K+ +KD++K K+ D++++ +K E + + + +
Sbjct: 280 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 339
Query: 382 NDSRNLKKASKNDDK-KKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKND 440
R ++ + D+K KKD K T + S+ S ++ ++ + S + + ++ K
Sbjct: 340 EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTI 399
Query: 441 EESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSK 500
+ + P+ +KK KK EK+ S++ ++++ S + + +L+K+ K
Sbjct: 400 KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK 459
Query: 501 EKKGSKKDIKKDARKDTESTDAEFDESSK 529
EK+ +K+ K+ + DA E +K
Sbjct: 460 EKEHNKEP-DSSVSKEVDDKDAPRTEENK 487
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/332 (23%), Positives = 152/332 (45%), Gaps = 45/332 (13%)
Query: 266 RNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD 325
R+ S+++SK++S + K++ K S+ +KD ++ K KK K ++
Sbjct: 197 RSKSRSSSKSHSRR---------KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE 247
Query: 326 VKKDTESTDAESGDSKDERKDTK---KDKKKLKKDDKKKDTKKYPE-STDTESGDAKDAR 381
+K + S+D+RKDT+ K+K+++K+ D++K+ ++ E + E G KD
Sbjct: 248 RRKSRSRSH-----SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD-- 300
Query: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
+ + D++KD +K D E E E KE +KD +DK+ K +K+ + +
Sbjct: 301 ------RDKEREKDREKDKEK-----DRERERE-KEHEKD--RDKEKEKEQDKEKEREKD 346
Query: 442 ESTDADSEPKGDSKK----GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKK 497
S + D + K D K + + + S ++ +++ ++ ++ S ++ K +
Sbjct: 347 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 406
Query: 498 HSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKK 557
S + +KKD K++ +D S E + S TS + +D + +E L K K
Sbjct: 407 PSPRSR-NKKDKKREKERDHISERRERERS------TSMRKSSNDRDGKEKLEKNSTSLK 459
Query: 558 IDESDGTSANSKMEGLESKRGFRMSSKKTTFN 589
E + +S + ++ K R K N
Sbjct: 460 EKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 491
Score = 80.9 bits (198), Expect = 3e-15
Identities = 75/351 (21%), Positives = 147/351 (41%), Gaps = 42/351 (11%)
Query: 137 SYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNS-KTVSKNC 195
S A PES + E K R SH +S+ S S SQ+ ++ S N
Sbjct: 174 SAAIEPESGKSNERKGGRSR---------SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR 224
Query: 196 SQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSD 255
S+ +KD + SK H K + ++ ++S++ + S
Sbjct: 225 SRSRQKDRRRSKSP-----HKKRSKSRERRKSRSRS---------------------HSR 258
Query: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
D+ + ++ + K+ + + +++ +K K+ D + E KD +KD +K ++
Sbjct: 259 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 318
Query: 316 NVKKDDKKKDVKKDTEST-DAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
++ + +KD K+ E D E KD K+ + +KK KK + + Y S + S
Sbjct: 319 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK--SRTPPRSYNASRRSRS 376
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ R SR+ +S++ K K+ + + S K+ ++++++D + + +
Sbjct: 377 SSRERRRRRSRS---SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 433
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
+S + S D D + K + EK+ K+ K+ K+A TE
Sbjct: 434 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 484
Score = 77.0 bits (188), Expect = 5e-14
Identities = 84/376 (22%), Positives = 159/376 (42%), Gaps = 67/376 (17%)
Query: 148 VEEKTKRQNEADKTPLKS----SHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDS 203
+EE KR EA + S ++ + K +S S T +S++S SK+ S++ + S
Sbjct: 159 LEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS---SKSHSRRKRSQS 215
Query: 204 KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDA 263
K+ +++ + +KD +RSK+ +
Sbjct: 216 KHRSRSHNR----SRSRQKDRRRSKSPHKK------------------------------ 241
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAK-------KSSDAESEDSKDAKKDSKKVKKN 316
R+ S+ K+ S +++ +KDT++ K K + E E K+ +K+ ++ K
Sbjct: 242 --RSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 299
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGD 376
+ +++KD +KD E D E K+ KD +DK+K K+ DK+K+ +K S + +
Sbjct: 300 DRDKEREKDREKDKEK-DREREREKEHEKD--RDKEKEKEQDKEKEREK-DRSKEIDEKR 355
Query: 377 AKDARND----SRNLKKASKNDDKKKDAKKITFS-----TDSESELESKESQKDEKKDKK 427
KD ++ S N + S++ +++ ++ S T + +S S ++KK
Sbjct: 356 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 415
Query: 428 DSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEME 487
D K + ++ D S + E +K D +K K K+ + N E
Sbjct: 416 DKKREKER----DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 471
Query: 488 SDLELKKDKKHSKEKK 503
S KD ++E K
Sbjct: 472 SKEVDDKDAPRTEENK 487
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 24/320 (7%)
Query: 306 AKKDSKKVKKNVKKDDKKKDVKKDTES---TDAESGDSKDERKDTKKDKKKLKKDDKKKD 362
A K+ ++V K V++ + ES + + G S+ + + K K+
Sbjct: 155 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 214
Query: 363 TKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE 422
+K S + KD R KK SK+ +++K + + S D + K +K+
Sbjct: 215 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-SHSRDKRKDTREKIKEKER 273
Query: 423 KKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE 482
K+K K ++ K E+ + D ++ K EK +KD +++ +K+ K +
Sbjct: 274 VKEKDREKERERE--KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 331
Query: 483 STEMESDLELKKDKKHSKEKKGSKKDIKKD------------ARKDTESTDAEFDESSKT 530
E E D E +++K SKE +K KK +R + SS
Sbjct: 332 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 391
Query: 531 GFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKR--GFRMSSKKTTF 588
+TS IK + S P ++ K D+ + E E +R R SS
Sbjct: 392 SPRTSKTIKRKSSRSP----SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 447
Query: 589 NEKGEKASTGRVPPSREKPP 608
EK EK ST K P
Sbjct: 448 KEKLEKNSTSLKEKEHNKEP 467
Score = 62.8 bits (151), Expect = 1e-09
Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 46/333 (13%)
Query: 129 KDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKS-SHENEQSKKSKSSSETNPESQN 187
K +++KGG ++ SK K+ + + ++ +S SH +S++ +P +
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 242
Query: 188 SKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
SK+ + S + + S++ +K E + K K+ + + + E E N D
Sbjct: 243 SKSRERRKS-RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD- 300
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
D E ++ ++ K+ + K +KD K +K D E E KD
Sbjct: 301 ------RDKERE------KDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR- 347
Query: 308 KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERK-----------DTKKDKKKLK- 355
SK++ + KKD K + + ++ S++ R+ +K K+K
Sbjct: 348 --SKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 405
Query: 356 --------KDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKN-DDKKKDAKKITFS 406
K DKK++ ++ S E R S +++K+S + D K+K K T
Sbjct: 406 SPSPRSRNKKDKKREKERDHISERRE-------RERSTSMRKSSNDRDGKEKLEKNSTSL 458
Query: 407 TDSESELESKESQKDEKKDKKDSKTDNKKSVKN 439
+ E E S E DK +T+ K N
Sbjct: 459 KEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 491
Score = 47.4 bits (111), Expect = 4e-05
Identities = 68/334 (20%), Positives = 127/334 (38%), Gaps = 36/334 (10%)
Query: 12 RTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQK 71
R+ S S S RK KH + + + R D+ R ++ +R+ +
Sbjct: 197 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR-QKDRRRSKSPHKKRSKSRERRKSRSRS 255
Query: 72 PAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDS 131
+ + + KI + + RE+ R K K+ K +D++ +KD
Sbjct: 256 HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE--KERGKNKDRDKEREKDREKDK 313
Query: 132 KKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTV 191
+K K +EK K Q++ + S E ++ +K S T P S N+
Sbjct: 314 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Query: 192 SKNCSQ-----------KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSE 240
S++ S+ + + SK K+ ++ ++ KKD KR K D ISE
Sbjct: 374 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK-ERDHISE---- 428
Query: 241 NSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES 300
+ + S + +R S + L+ + K+ + N + S
Sbjct: 429 -----------RRERERSTS----MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 473
Query: 301 E-DSKDA-KKDSKKVKKNVKKDDKKKDVKKDTES 332
E D KDA + + K++ N ++++ TE+
Sbjct: 474 EVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEA 507
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 97.1 bits (240), Expect = 5e-20
Identities = 129/561 (22%), Positives = 213/561 (37%), Gaps = 69/561 (12%)
Query: 107 KTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADK--TPLK 164
+ H KK E + L KD K TN + + E+ R N+A+K + +
Sbjct: 691 RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKE 750
Query: 165 SSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL 224
S + E+ + K + + + SK KN D K+ K SK+ F K KK+
Sbjct: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEKKN----DLKEDKISKEKEKIFKEDKEKLKKE- 805
Query: 225 KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNN-----SKNYSLK 279
+ + E C++N + SDD+ D W + S ++ ++
Sbjct: 806 -KVYREDSAFDEYCNKNQFLENEDTKFSLSDDQR---DRWFSDLSDSSFDFKGEDSWDSP 861
Query: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGD 339
T Y + AK + EDSK+ ++DS+ +K ++ + KKD + D S
Sbjct: 862 VTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFR--KKDRDYLDKNSEK 919
Query: 340 SKDERKDTK--------KDKKKLKKDDKKKDTKKYPEST-DTESGDAKDARNDSRNLKKA 390
K++ + K KDKK+ + + +D K ES + G AK LK+
Sbjct: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKEC 979
Query: 391 SKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK-KSVKNDEESTDADSE 449
+ KD F E +++ EKKD D + K K + E+S+D D
Sbjct: 980 GC-ESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKS 1038
Query: 450 PKGDSKKGKKD--------EKKGKKDSKKDDKKKDAKKNAESTE------------MESD 489
K +K +KD EKK K+ KD KD ++ A + + D
Sbjct: 1039 EKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISED 1098
Query: 490 LELKKDKKHSKEKKGSKKDIKKDARKDT------------ESTD------AEFDESSKTG 531
KKD K KEK DI D +D E++D + E +
Sbjct: 1099 FSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREA 1158
Query: 532 FKTSTKIKGSDTE-SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKT-TFN 589
+ + K SD + E K ++ D + K E + K + + T +
Sbjct: 1159 YASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYK 1218
Query: 590 EKGEKASTGRVPPSREKPPLP 610
++ ++AS + K LP
Sbjct: 1219 DRKDRASVDSTQDKKNKQKLP 1239
Score = 78.6 bits (192), Expect = 2e-14
Identities = 97/467 (20%), Positives = 194/467 (41%), Gaps = 55/467 (11%)
Query: 126 PLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN---EQSKKSKSSSETN 182
P ++ KK G P+ ++ +EKTK + +K+ K E E+ +K K +
Sbjct: 1005 PAREKEKKDG------PDKER--KEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCF 1056
Query: 183 PESQNSKTVSKNCSQKDKK-------DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
E +++K K+ KDK+ + +K + + KKD K+ K + I+
Sbjct: 1057 KEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIA 1116
Query: 236 EICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKS 295
+I ++ S + D +S + + + + L+ K++ ++
Sbjct: 1117 DIFTDES----------EDDRDSCMGSGFKMGEASDLPRTDGLQ----EKEEGREAYASD 1162
Query: 296 SDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDT-----KKD 350
+S D + ++ K ++ +KD D +D + E K +++ T +KD
Sbjct: 1163 RHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKD 1222
Query: 351 KKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
+ + KK+ +K P E + K A D K K+D + +K + S D+E
Sbjct: 1223 RASVDSTQDKKNKQKLP-----EKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAE 1277
Query: 411 SELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEP------KGDSKKGKKDEKKG 464
L K ++ + ++DS ++K S + + TD EP + + D+K
Sbjct: 1278 KSLLEKLEEEALHEYREDS--NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPR 1335
Query: 465 KKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK-DARKDTESTDAE 523
+ + K+ + S+ + + ++ KK EKK +D K+ +RKD+ + +
Sbjct: 1336 ESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKD 1395
Query: 524 FDESSKTGFKTSTKIKGSDTESE-ESLYKPGAKKKIDESDGTSANSK 569
F E+ G + K +D E E + + + +K D++D SK
Sbjct: 1396 FLEADAYGVSYNMK---ADIEDELDKTIELFSTEKKDKNDSEREPSK 1439
Score = 78.6 bits (192), Expect = 2e-14
Identities = 129/585 (22%), Positives = 226/585 (38%), Gaps = 65/585 (11%)
Query: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKR 154
+E+ R Y S H K ++ + + +K P +D +K G+ + K+ V EK K
Sbjct: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEP--RDRRKDRGAADAGRDKKEKVFEKHKE 1207
Query: 155 QNEADKTPL------KSSHENEQSKKSKSSSETNPESQNS---KTVSKNCSQKDKKDSKN 205
+ + + T ++S ++ Q KK+K E +++ K SK+ + DK+ SK
Sbjct: 1208 KKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE 1267
Query: 206 SKKTNT----EFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
K + + + L K + + + SND ISE+ S++ + GQ +
Sbjct: 1268 RKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDR------GQEPGLTAFL 1321
Query: 262 DAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321
+ ++ S + K+ + SS +S D + AKK+ K +K K +D
Sbjct: 1322 EVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKE--KAEKKEKGED 1379
Query: 322 KKKDVKKDTESTDAESGDSKD----ERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDA 377
K E G KD E+ + D + + K + ++ + S +
Sbjct: 1380 YK------------EGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
Query: 378 KDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSV 437
KD + R K + + K + I + + + +E +DEK+ +D D
Sbjct: 1428 KDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRH 1487
Query: 438 KNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKK--DAK---KNAESTEMESDLEL 492
DE E K + + K + KD +D+ + DAK K + E E +
Sbjct: 1488 HRDELLRHHRDEQK-PATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPV 1546
Query: 493 KKDKKHSKEKKGSKKDIKKDAR-KDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYK 551
K + K SK KKDAR ++ D + T F+ K + E +K
Sbjct: 1547 KMSNGNDKVAP-SKDPGKKDARPREKLLGDGDL---MMTSFERMLSQKDLEIEERHKRHK 1602
Query: 552 PGAK--KKIDESDG---TSANSKMEGLESKRGFRMSSKK-----TTFNEKGEKASTGRVP 601
K +K+ G +K K+G + +KK F +K K ST +P
Sbjct: 1603 ERMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKEST-PIP 1661
Query: 602 PSREKPPLPA----CEPSLPSPKVRRLCWCKMPPPPPKPRYAPLP 642
P+ E PA + L P ++ + P +P P P
Sbjct: 1662 PAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTP 1706
Score = 74.3 bits (181), Expect = 3e-13
Identities = 115/530 (21%), Positives = 207/530 (39%), Gaps = 67/530 (12%)
Query: 128 KKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQN 187
+ D +G S + ++ E + + K+P SS E K K
Sbjct: 576 ESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEG--------- 626
Query: 188 SKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
K V K+ ++ K+ + + + ++ L K+ + + SK +D I EN L+ +
Sbjct: 627 -KVVKKHKTKHKHKNKEKGQCSISQELKLKSFTY-EYEDSKQKSD--KAILLENDLSTEN 682
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSK-----NYSLKYTKYTKKDTKKNAKKSSDAESED 302
+ V + D + + L + SLK K T KD ++ ++ D ++
Sbjct: 683 KLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKA 742
Query: 303 SKDA---KKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
K+ +K K+ K + K+++KK KD S + D K+++ K+K+K+ K+DK
Sbjct: 743 EKERSLKEKSPKEEKLRLYKEERKKK-SKDRPSKLEKKNDLKEDK--ISKEKEKIFKEDK 799
Query: 360 KK--DTKKYPESTD----------TESGDAKDARNDSRNLKKASKNDDKKKDAK------ 401
+K K Y E + E+ D K + +D + + S D D K
Sbjct: 800 EKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWD 859
Query: 402 -KIT----FSTDSESELESKESQKDEKKDKKDSKTDNKKSV------KNDEESTDADSEP 450
+T +DS ++L + ++D K+ ++DS+ K+ K D + D +SE
Sbjct: 860 SPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
Query: 451 KGDSKKGKKD-----EKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK-- 503
+ + + K +K KK + + +D K ES + D K ++ H +E K
Sbjct: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKEC 979
Query: 504 ----GSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKID 559
G K D K E + K K + T+ E K K K +
Sbjct: 980 GCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSE 1039
Query: 560 ESDGTSANSKME---GLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
+S E + K+ + K T +K KAS + +EK
Sbjct: 1040 KSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEK 1089
Score = 69.7 bits (169), Expect = 8e-12
Identities = 107/472 (22%), Positives = 184/472 (38%), Gaps = 68/472 (14%)
Query: 111 KKAEYK----KSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSS 166
KKA ++ S +E + K + ++ P SK K+Q E +K
Sbjct: 400 KKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKV----- 454
Query: 167 HENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHT----KNNPK- 221
KK + E + K K CS + + +S S + + + L + K +P
Sbjct: 455 ------KKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLV 508
Query: 222 -------KDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDD-ESINFDAWLRNYSQNNS 273
L S TS+ S +N + D ++D+ ++I+ AW S ++S
Sbjct: 509 LKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDS 568
Query: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDV------- 326
T+ + SS+ S +S + ++ +K +KK
Sbjct: 569 ----------TRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGA 618
Query: 327 --KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARND- 383
K D E + +K + K+ +K + + ++ K K E + +S A ND
Sbjct: 619 VPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDL 678
Query: 384 -SRNLKKASKND-DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
+ N K K+D D K +K+ S+ +LE KE ++K K K NK ++
Sbjct: 679 STENKLKVLKHDRDHFKKEEKL-----SKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFR 733
Query: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501
E D ++ + + +K K+ K K+++KK +K + S LE K D K K
Sbjct: 734 EEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSK------DRPSKLEKKNDLKEDKI 787
Query: 502 KKGSKKDIKKDARK----DTESTDAEFDE-SSKTGF--KTSTKIKGSDTESE 546
K +K K+D K D+ FDE +K F TK SD + +
Sbjct: 788 SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRD 839
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/324 (21%), Positives = 124/324 (38%), Gaps = 32/324 (9%)
Query: 269 SQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK---KKD 325
S + N ++ K K K + + A +D + +D ++ + DDK KKD
Sbjct: 312 SSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQ-DRVPPVDDKHLLKKD 370
Query: 326 VKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKK--KDTKKYPESTDTESGDAKDARND 383
+K+T+S S + + TK + KK + DT E G + R
Sbjct: 371 YRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSD-EEDASVTVGTGEKLRLS 429
Query: 384 SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEES 443
+ + SK + + + + KE K +KK KK++K + K ++
Sbjct: 430 AHTILPGSK-------------TREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKF 476
Query: 444 TDADSEPKGDSKKGKKDEK--------KGKKDSKKDDKKKDAKKNAESTEMESDLELKKD 495
++SE + S+ G+ D KG KD + + ++ S K++
Sbjct: 477 CSSESESE-SSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQN 535
Query: 496 KKHS-KEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGA 554
H+ + K + D K S + +S++T TS S+ S ESL KP
Sbjct: 536 PSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRL-TSESDYSSEGSSVESL-KPVR 593
Query: 555 KKKIDESDGTSANSKMEGLESKRG 578
K++ + + K L S G
Sbjct: 594 KRQEHRKRASLSEKKSPFLSSAEG 617
Score = 39.7 bits (91), Expect = 0.009
Identities = 51/248 (20%), Positives = 86/248 (34%), Gaps = 39/248 (15%)
Query: 361 KDTKKYPESTDTESGDAKDA-----------RNDSRNLKKASKNDDKKKDAKKITFSTDS 409
K T E + TES + +DA N +K K+ K + +K T
Sbjct: 286 KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKD 345
Query: 410 ESELESKESQK------DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
E E + + Q D+ KKD + + K + + S K ++ KK +
Sbjct: 346 EYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHR 405
Query: 464 GKKDSKKDDKKKDAKKNAESTEMESDLEL-----------KKDKKHSKEKKGSKKDIK-- 510
D+ ++ E + + L K+ K+ +K KK KK+ K
Sbjct: 406 ILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGR 465
Query: 511 ---------KDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDES 561
K ++ES +E E + +S +KGS ++ S
Sbjct: 466 EVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSS 525
Query: 562 DGTSANSK 569
G+SA K
Sbjct: 526 HGSSAAQK 533
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 97.1 bits (240), Expect = 5e-20
Identities = 120/547 (21%), Positives = 210/547 (38%), Gaps = 70/547 (12%)
Query: 25 RKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRK- 83
RKS + T K ++ ND + P + I + Q P KW + F
Sbjct: 1246 RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI----------QVPQSKWDKDDFESE 1295
Query: 84 ---ILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT 140
+ PI + + + +++ T +++ K K+S+ P +K K T
Sbjct: 1296 EEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESE------PSEKIQK------FT 1343
Query: 141 NPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK 200
S +I++ HE + SK S SS + + ++ + K +K K
Sbjct: 1344 KDVSHEIIQ-----------------HEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK 1386
Query: 201 KDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESIN 260
++ K++N + L+ + N K + SK + + S N DF + D+ +
Sbjct: 1387 NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFT----PNRDKKTD 1442
Query: 261 FDAWLRNYSQNNSKNYSLKYTKYT-----KKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
+D R YS + ++ + T+ KD+ K E + K DSKK
Sbjct: 1443 YDT--REYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1500
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKL---KKDDKKKDTKKY-----P 367
+ +D K D K T T + ++K K+ KD++K +++K+ K P
Sbjct: 1501 SPSRDRKPHD-HKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNP 1559
Query: 368 ESTDTESGDA-----KDARNDSRNLKKASK-NDDKKKDAKKITFSTD-SESELESKESQK 420
T E K L +S+ + D ++ + F D +ES+ ES S K
Sbjct: 1560 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1619
Query: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
+E+ SK K V+ +ES D + + + + S+ ++
Sbjct: 1620 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRS 1679
Query: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
S+ ++ + K KK KEKK KK K K T+ E ++S K K K
Sbjct: 1680 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1739
Query: 541 SDTESEE 547
D E E+
Sbjct: 1740 KDKEKEK 1746
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/525 (21%), Positives = 207/525 (39%), Gaps = 64/525 (12%)
Query: 112 KAEYKKSKDEKGGTPLKKDSK-----KKGGSYATNPESKQIVE---EKTKRQNEADK--- 160
K E +K K E+ G +S K + P K+ +E EK R E DK
Sbjct: 1109 KGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL 1168
Query: 161 -TPLKSSHENEQSKKSKSSSE----TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTE--- 212
P K N ++ K S+E T S+ ++ S Q+ K K T TE
Sbjct: 1169 SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSS 1228
Query: 213 -----FLHTKNNPKKDLKRSKTSNDP-------ISEICSENSL---NVDFLMLVGQSDDE 257
+ T + +++S+ D + E ++N+ +V ++ V QS +
Sbjct: 1229 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWD 1288
Query: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK--NAKKSSDAESEDSKDAKKDSKKVKK 315
+F++ + + K K + K N K + ESE S+ +K +K V
Sbjct: 1289 KDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH 1348
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG 375
+ + + VK S +E G +KD + + K+ + + K+ E G
Sbjct: 1349 EIIQHE----VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1404
Query: 376 DAKDARNDSRNLKKASKNDDKKKDAKK-ITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ K S+ + + K+D + + K T + D +++ +++E +++D+K+ T K
Sbjct: 1405 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRK 1464
Query: 435 KSVKNDEESTDADS----EPKGDSKKGKKDEKKGKKDSKKDDKKKD------AKKNAEST 484
S +++S E + KKG D KK +D K D K+ E T
Sbjct: 1465 DSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEET 1524
Query: 485 EMESDLELKKDKKHSKEKKGSKKDI---------KKDARKDTESTDAEFDESS---KTGF 532
+ K +KH E + +K+ + + + E + D+S+ K
Sbjct: 1525 KSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQL 1584
Query: 533 KTSTKIKGSDT-ESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
S+++ T E++E+ ++P + ES+ + + G SK
Sbjct: 1585 SHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISK 1629
Score = 72.0 bits (175), Expect = 2e-12
Identities = 126/579 (21%), Positives = 218/579 (37%), Gaps = 80/579 (13%)
Query: 88 PPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEK-GGTPLKKDSKKKGGSYATNPESKQ 146
PPI A+E+TP KT K+ KDEK GTP K SK S + E+K
Sbjct: 1023 PPI-KKAKEETP-------KTDNTKSSSSSQKDEKITGTPRKAHSK----SAKEHQETKP 1070
Query: 147 IVEEKTKRQNEADKTPLKSSHENEQSKKSKSSS---ETNPESQNSKTVSKNCSQKDKKDS 203
+ EEK K+ D K + + E++KK + + E + KT K + + S
Sbjct: 1071 VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSS 1130
Query: 204 -KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISE----ICSENSLNVDFLMLVGQSDDES 258
K SK TE + K +PK+ ++ D E S + + G+ +
Sbjct: 1131 MKISKLEVTEIV--KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGST 1188
Query: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK--NAKKSSDAESEDSKDAKKDSKKVKKN 316
N + S + +K K K +K + SS + + + V+K+
Sbjct: 1189 ENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKS 1248
Query: 317 VKKDDKKKDVKKDTESTDAESG-------------DSKDERKDTKKDKKKLKKDD----- 358
+K D K+ V K E + ++ SK ++ D + +++ +K
Sbjct: 1249 EEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSV 1308
Query: 359 ------------KKKDTKKYPESTDTESGDAKDARNDS-----RNLKKASKNDDKKKDAK 401
K + KYPE S + D ++ K+SKN + K
Sbjct: 1309 GKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK 1368
Query: 402 KITFSTD-SESELESKESQKDEKKDKKDSKTDNKKSVKN----DEESTDADSEPKGDSKK 456
T D S E E+ E +K+ + +K+S D N + S +A + K DS +
Sbjct: 1369 --TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1426
Query: 457 GKKDEKKGKKDSKKDD--------KKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508
++ KK D K+ +KN + +S K K K ++D
Sbjct: 1427 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1486
Query: 509 IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANS 568
+ K D++ +++ K +T E +S+ K K + E A +
Sbjct: 1487 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDR--EKHVLEARN 1544
Query: 569 KMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKP 607
E +K + ++ +T + ++ TG++ S KP
Sbjct: 1545 NKESSGNKLLYILNPPET---QVEKEQITGQIDKSTVKP 1580
Score = 70.9 bits (172), Expect = 4e-12
Identities = 88/359 (24%), Positives = 145/359 (40%), Gaps = 41/359 (11%)
Query: 269 SQNNSKNYSLKYTK---YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK-- 323
S+N NY K + + +KD K+ +K S+ D K K KK +K K ++ +
Sbjct: 857 SRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNK--HKKHRKRRKGEESEGF 914
Query: 324 ------KDVKKDTESTDAESGDSKDERKDTKKDKKKLKKD---DKKKDTKKYPESTDTES 374
+ +K E T E + +D +D D + T K D
Sbjct: 915 LNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRE 974
Query: 375 GDAKDARNDSRNLKK----ASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSK 430
D A+ D K SK ++ K AK D E E + +K ++ K
Sbjct: 975 RDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPK 1034
Query: 431 TDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDL 490
TDN KS + ++ P+ K K+ ++ K K++ KKD K+ +S ++ +
Sbjct: 1035 TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQE-TKPVKEEKVKKDYSKDVKSEKLTTK- 1092
Query: 491 ELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLY 550
E K K + K K K K+ + + + D +F+ SS +K S E E +
Sbjct: 1093 EEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSS---------MKISKLEVTE-IV 1142
Query: 551 KPGAKKKIDESDGTSANSKMEGLESKRGFRMS--SKKTTFN-EKGEK-ASTGRVPPSRE 605
KP K+K++ KM+ K +S +KK N E G+K ST + ++E
Sbjct: 1143 KPSPKRKMEPD-----TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKE 1196
Score = 70.9 bits (172), Expect = 4e-12
Identities = 89/396 (22%), Positives = 150/396 (37%), Gaps = 77/396 (19%)
Query: 92 TAAREQTPFRHLYTSKTHLKKAEYKKSK--DEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
T A F KT EY SK DEK +KDS + A+ ++K E
Sbjct: 1425 TRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREE 1484
Query: 150 EKTKRQNEADKTPLKSSHENEQSKKS-KSSSETNPESQNSKTVSKN-CSQKDKK--DSKN 205
++ D SS ++ K++ +T ++ +K+V KN C ++K +++N
Sbjct: 1485 RDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARN 1544
Query: 206 SKKTN-TEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAW 264
+K+++ + L+ N P+ +++ + + GQ D
Sbjct: 1545 NKESSGNKLLYILNPPETQVEKEQ---------------------ITGQID--------- 1574
Query: 265 LRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKK 324
K T K +++ SSD E + A
Sbjct: 1575 --------------KSTVKPKPQLSHSSRLSSDLTRETDEAA------------------ 1602
Query: 325 DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG-DAKDARND 383
+ D +D+ES S E + + + KD K K +K ES DT + +RN
Sbjct: 1603 -FEPDYNESDSESNVSVKEEESSGN----ISKDLKDKIVEKAKESLDTAAVVQVGISRNQ 1657
Query: 384 SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK-DKKDSKTDNKKSVKNDEE 442
S + S + + + S S ES++S+K +KK +KK K K
Sbjct: 1658 SHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHA 1717
Query: 443 STDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK 478
T+ + E K K KK + K KD +K+ +K D K
Sbjct: 1718 GTEVELE-KSQKHKHKKKKSKKNKDKEKEKEKDDQK 1752
Score = 65.1 bits (157), Expect = 2e-10
Identities = 90/459 (19%), Positives = 182/459 (39%), Gaps = 49/459 (10%)
Query: 102 HLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT---NPE----SKQIVEEKTKR 154
H T K+ E + + + G KK K++ G + NPE S++ E
Sbjct: 874 HNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVE 933
Query: 155 QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVS-KNCSQKDKKDSKNSKKTNTEF 213
+N+ D + S ++ ++ E ++++++ K+ S+KDK++
Sbjct: 934 ENKTDSLFVLPSRDD--------ATPVRDEPMDAESITFKSVSEKDKRE----------- 974
Query: 214 LHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNS 273
++ PK ++K ND + EN ++ + E ++ + R S +
Sbjct: 975 ---RDKPKAKGDKTKRKNDGSAVSKKEN------IVKPAKGPQEKVDGE---RERSPRSE 1022
Query: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVK-----KNVKKDDKKKDVKK 328
+ K D K++ S E K SK K K VK++ KKD K
Sbjct: 1023 PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1082
Query: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
D +S + + K ++ + K K + +K+ T++ D ES K ++ + +
Sbjct: 1083 DVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIV 1142
Query: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448
K S + D +K+ + + + S ++K + + K + +++ N +E ++
Sbjct: 1143 KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSE--- 1199
Query: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508
+ + S K K+++ KGK K + + + T S + S+EK +K+
Sbjct: 1200 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS--TGGSPVRKSEEKTDTKRT 1257
Query: 509 IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547
+ K + A ++ +K D ESEE
Sbjct: 1258 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1296
Score = 54.7 bits (130), Expect = 3e-07
Identities = 69/280 (24%), Positives = 123/280 (43%), Gaps = 46/280 (16%)
Query: 94 AREQTPFRHLYTSKTHLKKAEYKK-----SKDEKGGTPLKKDSKKKGGS---YATNPESK 145
+R++ P H T T E K KD + +++K+ G+ Y NP
Sbjct: 1503 SRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPET 1562
Query: 146 QIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN 205
Q+ EK + + DK+ +K + + S S+ SS+ E+ + + D +S +
Sbjct: 1563 QV--EKEQITGQIDKSTVKP--KPQLSHSSRLSSDLTRETDEA------AFEPDYNESDS 1612
Query: 206 SKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWL 265
+ + + N KDLK D I E E SL+ ++ VG S ++S + +
Sbjct: 1613 ESNVSVKEEESSGNISKDLK------DKIVEKAKE-SLDTAAVVQVGISRNQSHSSPSVS 1665
Query: 266 --RNYSQNNS--KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK------KVKK 315
R++S + S +++S + +D+KK KK + + K KK K +++K
Sbjct: 1666 PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1725
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLK 355
+ K KKK KK +KD+ K+ +KD +K+K
Sbjct: 1726 SQKHKHKKKKSKK-----------NKDKEKEKEKDDQKVK 1754
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 97.1 bits (240), Expect = 5e-20
Identities = 120/547 (21%), Positives = 210/547 (38%), Gaps = 70/547 (12%)
Query: 25 RKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRK- 83
RKS + T K ++ ND + P + I + Q P KW + F
Sbjct: 1280 RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI----------QVPQSKWDKDDFESE 1329
Query: 84 ---ILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT 140
+ PI + + + +++ T +++ K K+S+ P +K K T
Sbjct: 1330 EEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESE------PSEKIQK------FT 1377
Query: 141 NPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK 200
S +I++ HE + SK S SS + + ++ + K +K K
Sbjct: 1378 KDVSHEIIQ-----------------HEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK 1420
Query: 201 KDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESIN 260
++ K++N + L+ + N K + SK + + S N DF + D+ +
Sbjct: 1421 NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFT----PNRDKKTD 1476
Query: 261 FDAWLRNYSQNNSKNYSLKYTKYT-----KKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
+D R YS + ++ + T+ KD+ K E + K DSKK
Sbjct: 1477 YDT--REYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNS 1534
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKL---KKDDKKKDTKKY-----P 367
+ +D K D K T T + ++K K+ KD++K +++K+ K P
Sbjct: 1535 SPSRDRKPHD-HKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNP 1593
Query: 368 ESTDTESGDA-----KDARNDSRNLKKASK-NDDKKKDAKKITFSTD-SESELESKESQK 420
T E K L +S+ + D ++ + F D +ES+ ES S K
Sbjct: 1594 PETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVK 1653
Query: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
+E+ SK K V+ +ES D + + + + S+ ++
Sbjct: 1654 EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRS 1713
Query: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
S+ ++ + K KK KEKK KK K K T+ E ++S K K K
Sbjct: 1714 HSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773
Query: 541 SDTESEE 547
D E E+
Sbjct: 1774 KDKEKEK 1780
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/525 (21%), Positives = 207/525 (39%), Gaps = 64/525 (12%)
Query: 112 KAEYKKSKDEKGGTPLKKDSK-----KKGGSYATNPESKQIVE---EKTKRQNEADK--- 160
K E +K K E+ G +S K + P K+ +E EK R E DK
Sbjct: 1143 KGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL 1202
Query: 161 -TPLKSSHENEQSKKSKSSSE----TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTE--- 212
P K N ++ K S+E T S+ ++ S Q+ K K T TE
Sbjct: 1203 SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSS 1262
Query: 213 -----FLHTKNNPKKDLKRSKTSNDP-------ISEICSENSL---NVDFLMLVGQSDDE 257
+ T + +++S+ D + E ++N+ +V ++ V QS +
Sbjct: 1263 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWD 1322
Query: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK--NAKKSSDAESEDSKDAKKDSKKVKK 315
+F++ + + K K + K N K + ESE S+ +K +K V
Sbjct: 1323 KDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH 1382
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG 375
+ + + VK S +E G +KD + + K+ + + K+ E G
Sbjct: 1383 EIIQHE----VKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1438
Query: 376 DAKDARNDSRNLKKASKNDDKKKDAKK-ITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ K S+ + + K+D + + K T + D +++ +++E +++D+K+ T K
Sbjct: 1439 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRK 1498
Query: 435 KSVKNDEESTDADS----EPKGDSKKGKKDEKKGKKDSKKDDKKKD------AKKNAEST 484
S +++S E + KKG D KK +D K D K+ E T
Sbjct: 1499 DSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEET 1558
Query: 485 EMESDLELKKDKKHSKEKKGSKKDI---------KKDARKDTESTDAEFDESS---KTGF 532
+ K +KH E + +K+ + + + E + D+S+ K
Sbjct: 1559 KSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQL 1618
Query: 533 KTSTKIKGSDT-ESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
S+++ T E++E+ ++P + ES+ + + G SK
Sbjct: 1619 SHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISK 1663
Score = 72.0 bits (175), Expect = 2e-12
Identities = 126/579 (21%), Positives = 218/579 (37%), Gaps = 80/579 (13%)
Query: 88 PPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEK-GGTPLKKDSKKKGGSYATNPESKQ 146
PPI A+E+TP KT K+ KDEK GTP K SK S + E+K
Sbjct: 1057 PPI-KKAKEETP-------KTDNTKSSSSSQKDEKITGTPRKAHSK----SAKEHQETKP 1104
Query: 147 IVEEKTKRQNEADKTPLKSSHENEQSKKSKSSS---ETNPESQNSKTVSKNCSQKDKKDS 203
+ EEK K+ D K + + E++KK + + E + KT K + + S
Sbjct: 1105 VKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSS 1164
Query: 204 -KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISE----ICSENSLNVDFLMLVGQSDDES 258
K SK TE + K +PK+ ++ D E S + + G+ +
Sbjct: 1165 MKISKLEVTEIV--KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGST 1222
Query: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK--NAKKSSDAESEDSKDAKKDSKKVKKN 316
N + S + +K K K +K + SS + + + V+K+
Sbjct: 1223 ENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKS 1282
Query: 317 VKKDDKKKDVKKDTESTDAESG-------------DSKDERKDTKKDKKKLKKDD----- 358
+K D K+ V K E + ++ SK ++ D + +++ +K
Sbjct: 1283 EEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSV 1342
Query: 359 ------------KKKDTKKYPESTDTESGDAKDARNDS-----RNLKKASKNDDKKKDAK 401
K + KYPE S + D ++ K+SKN + K
Sbjct: 1343 GKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK 1402
Query: 402 KITFSTD-SESELESKESQKDEKKDKKDSKTDNKKSVKN----DEESTDADSEPKGDSKK 456
T D S E E+ E +K+ + +K+S D N + S +A + K DS +
Sbjct: 1403 --TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1460
Query: 457 GKKDEKKGKKDSKKDD--------KKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508
++ KK D K+ +KN + +S K K K ++D
Sbjct: 1461 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1520
Query: 509 IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANS 568
+ K D++ +++ K +T E +S+ K K + E A +
Sbjct: 1521 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDR--EKHVLEARN 1578
Query: 569 KMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKP 607
E +K + ++ +T + ++ TG++ S KP
Sbjct: 1579 NKESSGNKLLYILNPPET---QVEKEQITGQIDKSTVKP 1614
Score = 70.9 bits (172), Expect = 4e-12
Identities = 89/396 (22%), Positives = 150/396 (37%), Gaps = 77/396 (19%)
Query: 92 TAAREQTPFRHLYTSKTHLKKAEYKKSK--DEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
T A F KT EY SK DEK +KDS + A+ ++K E
Sbjct: 1459 TRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREE 1518
Query: 150 EKTKRQNEADKTPLKSSHENEQSKKS-KSSSETNPESQNSKTVSKN-CSQKDKK--DSKN 205
++ D SS ++ K++ +T ++ +K+V KN C ++K +++N
Sbjct: 1519 RDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARN 1578
Query: 206 SKKTN-TEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAW 264
+K+++ + L+ N P+ +++ + + GQ D
Sbjct: 1579 NKESSGNKLLYILNPPETQVEKEQ---------------------ITGQID--------- 1608
Query: 265 LRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKK 324
K T K +++ SSD E + A
Sbjct: 1609 --------------KSTVKPKPQLSHSSRLSSDLTRETDEAA------------------ 1636
Query: 325 DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG-DAKDARND 383
+ D +D+ES S E + + + KD K K +K ES DT + +RN
Sbjct: 1637 -FEPDYNESDSESNVSVKEEESSGN----ISKDLKDKIVEKAKESLDTAAVVQVGISRNQ 1691
Query: 384 SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK-DKKDSKTDNKKSVKNDEE 442
S + S + + + S S ES++S+K +KK +KK K K
Sbjct: 1692 SHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHA 1751
Query: 443 STDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK 478
T+ + E K K KK + K KD +K+ +K D K
Sbjct: 1752 GTEVELE-KSQKHKHKKKKSKKNKDKEKEKEKDDQK 1786
Score = 65.1 bits (157), Expect = 2e-10
Identities = 90/459 (19%), Positives = 182/459 (39%), Gaps = 49/459 (10%)
Query: 102 HLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYAT---NPE----SKQIVEEKTKR 154
H T K+ E + + + G KK K++ G + NPE S++ E
Sbjct: 908 HNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVE 967
Query: 155 QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVS-KNCSQKDKKDSKNSKKTNTEF 213
+N+ D + S ++ ++ E ++++++ K+ S+KDK++
Sbjct: 968 ENKTDSLFVLPSRDD--------ATPVRDEPMDAESITFKSVSEKDKRE----------- 1008
Query: 214 LHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNS 273
++ PK ++K ND + EN ++ + E ++ + R S +
Sbjct: 1009 ---RDKPKAKGDKTKRKNDGSAVSKKEN------IVKPAKGPQEKVDGE---RERSPRSE 1056
Query: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVK-----KNVKKDDKKKDVKK 328
+ K D K++ S E K SK K K VK++ KKD K
Sbjct: 1057 PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSK 1116
Query: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
D +S + + K ++ + K K + +K+ T++ D ES K ++ + +
Sbjct: 1117 DVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIV 1176
Query: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448
K S + D +K+ + + + S ++K + + K + +++ N +E ++
Sbjct: 1177 KPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSE--- 1233
Query: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD 508
+ + S K K+++ KGK K + + + T S + S+EK +K+
Sbjct: 1234 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS--TGGSPVRKSEEKTDTKRT 1291
Query: 509 IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547
+ K + A ++ +K D ESEE
Sbjct: 1292 VIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1330
Score = 54.7 bits (130), Expect = 3e-07
Identities = 69/280 (24%), Positives = 123/280 (43%), Gaps = 46/280 (16%)
Query: 94 AREQTPFRHLYTSKTHLKKAEYKK-----SKDEKGGTPLKKDSKKKGGS---YATNPESK 145
+R++ P H T T E K KD + +++K+ G+ Y NP
Sbjct: 1537 SRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPET 1596
Query: 146 QIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN 205
Q+ EK + + DK+ +K + + S S+ SS+ E+ + + D +S +
Sbjct: 1597 QV--EKEQITGQIDKSTVKP--KPQLSHSSRLSSDLTRETDEA------AFEPDYNESDS 1646
Query: 206 SKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWL 265
+ + + N KDLK D I E E SL+ ++ VG S ++S + +
Sbjct: 1647 ESNVSVKEEESSGNISKDLK------DKIVEKAKE-SLDTAAVVQVGISRNQSHSSPSVS 1699
Query: 266 --RNYSQNNS--KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK------KVKK 315
R++S + S +++S + +D+KK KK + + K KK K +++K
Sbjct: 1700 PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEK 1759
Query: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLK 355
+ K KKK KK +KD+ K+ +KD +K+K
Sbjct: 1760 SQKHKHKKKKSKK-----------NKDKEKEKEKDDQKVK 1788
Score = 46.2 bits (108), Expect = 9e-05
Identities = 83/445 (18%), Positives = 171/445 (38%), Gaps = 50/445 (11%)
Query: 193 KNCSQKDKKDSKNSKKTNT---EFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM 249
+ +++KK SK + TN E + K K+ + S P S S
Sbjct: 646 RRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYT---- 701
Query: 250 LVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESED------- 302
+S S ++ R++S+++S++YS + Y ++ K+ S + S
Sbjct: 702 -YSKSRSGSTRSRSYSRSFSRSHSRSYS-RSPPYPRRGRGKSRNYRSRSRSHGYHRSRSR 759
Query: 303 ------------SKDAKKDSKKVKKNVKKDDKKKDVKK---------DTESTDAESGDSK 341
S A + K+NV + + +++ D ++ S D +
Sbjct: 760 SPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFR 819
Query: 342 DE-RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDA 400
D K+ ++ ++ ++ +K K Y ++ + R L +N +
Sbjct: 820 DPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGR 879
Query: 401 KKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKD 460
++ S + S EK +D + ++ES +A + KG+ K +
Sbjct: 880 REDYVGGQSHRS-RNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRK 938
Query: 461 EKKGKKDS--KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDT- 517
+KG++ + + ++K+ E T +E + S++ +D DA T
Sbjct: 939 RRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITF 998
Query: 518 ----ESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKP--GAKKKIDESDGTSANSK-- 569
E E D+ G KT K GS +E++ KP G ++K+D S S+
Sbjct: 999 KSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPP 1058
Query: 570 MEGLESKRGFRMSSKKTTFNEKGEK 594
++ + + ++K ++ ++K EK
Sbjct: 1059 IKKAKEETPKTDNTKSSSSSQKDEK 1083
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 94.0 bits (232), Expect = 4e-19
Identities = 136/599 (22%), Positives = 249/599 (41%), Gaps = 65/599 (10%)
Query: 60 RHDKRKLEEGQKPAHKWIRHSFRKILQ-WPPIYTAAREQTPFRHLYTSKTHLKKAEYKKS 118
RH RK + + H F K + + P +++Q P R LY+S + +
Sbjct: 355 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNK 414
Query: 119 KDEKGGTPLKKDSK---KKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKS 175
K + + + S + Y + E KQ + K K +N+ + EN++ K+
Sbjct: 415 KISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ------NKNKENQELKQE 468
Query: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKK------TNTEFLH--TKNNPKKDLKRS 227
K E + + +CS+K +++ K T+ H T +PK S
Sbjct: 469 KEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLS 528
Query: 228 KTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTK-- 285
+ + P+ + ++ L+ + Q D + +D + +S S K+ + +K
Sbjct: 529 EKQSTPLKQEHTKTCLSPGSSEMSLQPD--LVRYDNTESEFLPESSSVKSCKHKEKSKHQ 586
Query: 286 KD------TKKNAKKSSDAES---EDSKDAKKDSKKVKKNVKKDD-KKKDVKKDTESTDA 335
KD K NAK + S E+S K K K +KK K K+ +K+ +
Sbjct: 587 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 646
Query: 336 ESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDD 395
E K + KD+ K+ ++ + D++ + + +S +TE + ++S L+K SK +
Sbjct: 647 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFL-NMEHESLTLEKKSKLEK 705
Query: 396 KKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEES--TDADSE---- 449
KD K S+ +E K +K+ +K + + K +K + E+ TD DSE
Sbjct: 706 NIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL 765
Query: 450 ---------------PKGDSKKGKKD--EKKGKKDSKKDDKKKDAKKNAESTEMESDLEL 492
+ D +K +K E K K + + K+KD +K T E + ++
Sbjct: 766 GMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT-FEKEKKI 824
Query: 493 KKDKKHSKEKKGSKKDIKKDARKD---TESTDAEFDESSKTGFKTSTKIKGSDT--ESEE 547
K + K K+K + + K KD + T+ E K+ K + IK +D +S E
Sbjct: 825 KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKS--KNTAAIKKTDDREKSRE 882
Query: 548 SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
+ + K+K E + A SK + L K+ + + + + +EKG+ R +EK
Sbjct: 883 KMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 940
Score = 76.6 bits (187), Expect = 6e-14
Identities = 129/600 (21%), Positives = 224/600 (37%), Gaps = 111/600 (18%)
Query: 95 REQTPFRHLYTSKT----HL------KKAEYKKSKDEKGGTPLKKDSKK---KGGSYATN 141
RE+ FR ++ K HL K ++ EK TPLK++ K GS +
Sbjct: 493 REEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMS 552
Query: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK 201
+ + + T+ + + + +KS E+SK K E N+K ++ S +
Sbjct: 553 LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFEN 612
Query: 202 DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
KK + E K + K +R K + E E D + S+ F
Sbjct: 613 SDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS----AKELQRSVEF 668
Query: 262 DA--WLRNYSQN--------NSKNYSLKYTKYTKKDTK-KNAKKSSDAESEDSKDAKKDS 310
D W N+ ++ N ++ SL K +K + K+ K + + ++ K++
Sbjct: 669 DREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEER 728
Query: 311 KKVKKNVKK---DDKKKDVKKDTES--TDAESG--------------------------- 338
K+KK +K ++K KD+K++ E+ TD +S
Sbjct: 729 DKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQ 788
Query: 339 -----DSKD----------------ERKDTKKDKKKLKKDDKKKDTKKYPESTDT----- 372
+SK+ ERK +K+KK + +KD E D
Sbjct: 789 EKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKD 848
Query: 373 -----ESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESE------LESKESQKD 421
+ S+N K DD++K +K+ D E ESKE
Sbjct: 849 KLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLM 908
Query: 422 EKKDKKDSKTDNKKSV--KNDEESTDADSEPKGDSKK-----GKKDEKKGKKDSKKDDKK 474
EKK+K+ ++ KS KN E+ + D + K K+ K ++ KK S D K
Sbjct: 909 EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 968
Query: 475 KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKT 534
+K E D LK K+KK KDI + +D + + K +
Sbjct: 969 AQHEKPLSLKEKTKDEPLKTPDGKEKDKK--DKDIDRYKERDKHKDKIQINSLLKLKSEA 1026
Query: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKM---EGLESKRGFRMSSKKTTFNEK 591
S S+++ +P K+ +++ ++ +M + LE ++ + +K EK
Sbjct: 1027 DKPKPKSSPASKDT--RPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEK 1084
Score = 73.2 bits (178), Expect = 7e-13
Identities = 105/516 (20%), Positives = 206/516 (39%), Gaps = 64/516 (12%)
Query: 103 LYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTP 162
L+ + H KKSK EK KD K + + + + EE+ K + E++K
Sbjct: 686 LFLNMEHESLTLEKKSKLEKN----IKDDKSTKEKHVS--KERNFKEERDKIKKESEK-- 737
Query: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEF----LHTKN 218
S E+ K K E P ++S+ S S ++ + + + H K
Sbjct: 738 ---SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 794
Query: 219 NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSL 278
+ +K KRS+ I ++ + + +S+ + ++ + + +
Sbjct: 795 SKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL---- 850
Query: 279 KYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKD--TESTDAE 336
Y+ +T+K K+ K + A + + D +K +K+ + K DK+K K+ ES +
Sbjct: 851 -YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDR---KHDKEKPEKERHLAESKEKH 906
Query: 337 SGDSKDERKDTKKDKKKLKKDDKKKDTK--KYPESTDTESGDAKDARNDSRNLKKASKND 394
+ K+++ D + K K +K+KD + K +S D ES + ++++ K + +
Sbjct: 907 LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDG 966
Query: 395 DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS------ 448
+K + K ++ ++ E ++ ++KDKKD D K ++ +S
Sbjct: 967 NKAQHEKPLSLKEKTKDE--PLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1024
Query: 449 ---EPKGDSKKGKKDEKKGKKDSKKDD------------------------KKKDAKKNA 481
+PK S KD + +K DD K+K +K
Sbjct: 1025 EADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEK 1084
Query: 482 ESTEMESDLELKKD-KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
E + LELK K+ +K K+ + K +E TDA + + + S + +
Sbjct: 1085 ERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA-YTKEKQPKDAVSNRSQS 1143
Query: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
DT++ +L K + + ++ GL S+
Sbjct: 1144 VDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSR 1179
Score = 64.3 bits (155), Expect = 3e-10
Identities = 118/618 (19%), Positives = 234/618 (37%), Gaps = 96/618 (15%)
Query: 49 SRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKT 108
++P++S+ + + + + G+K K +S ++ + +E++ +
Sbjct: 7 TKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTI 66
Query: 109 HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNP----------ESKQ--IVEEKTKRQN 156
+ E + S EK G P KK +KK+ G+ + P E KQ ++ + T R N
Sbjct: 67 SPSRNEERDSDTEKEG-PEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDN 125
Query: 157 EADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHT 216
D TP S KK+ SSS QKDK + +N + +
Sbjct: 126 SPDSTPNHPSQTTPAQKKTPSSSS---------------RQKDKVNKRNERGETPLHMAA 170
Query: 217 KNNPKKDLKR--SKTSN---------DPISEICSENSLNVDFLMLVGQSD--DESINFDA 263
K +K S +N P+ E C+ +V +++ +D + ++ D
Sbjct: 171 IRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 230
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
L + + + ++ ++ + N + ++++ + +K+ V D
Sbjct: 231 PLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE---LLLKREVPLSDDD 287
Query: 324 KDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYP--------ESTDTESG 375
+ D+E + + S DE D++ +K L + K+ K P E D +
Sbjct: 288 ESY-TDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDE 346
Query: 376 DAKDARNDSRNLKKASKNDD------------------------KKKDAKKITFSTDSES 411
+ +D L+K + ++ KK+ ++ +S+ S
Sbjct: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 406
Query: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKD 471
+ E+ +++K +T N E + + KG K+ K++ K K++++
Sbjct: 407 DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNK-NKENQEL 465
Query: 472 DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTE------STDAEFD 525
++K+ K+N T + + L +K +E K KD DT ST
Sbjct: 466 KQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKD---DTSLHLFHISTGKSPK 522
Query: 526 ESSKTGFKTSTKIKGSDTE-------SEESLYKPGAKKKIDESDGTSANSKMEGLESKRG 578
S K ST +K T+ SE SL + ES+ +S ++ + K
Sbjct: 523 HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKE- 581
Query: 579 FRMSSKKTTFNEKGEKAS 596
+ +K E GEK++
Sbjct: 582 -KSKHQKDFHLEFGEKSN 598
Score = 47.0 bits (110), Expect = 6e-05
Identities = 78/398 (19%), Positives = 153/398 (38%), Gaps = 36/398 (9%)
Query: 48 KSRPLKSQITVTRHDKRKLEEGQKPAHKWIRH---SFRKILQWPPIYTAAREQTPFRHLY 104
K +P K + D K+E K I+H S + L +E+ +
Sbjct: 796 KEKPEKRS-QIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 854
Query: 105 TSKTH-----------LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTK 153
T K H +KK + ++ EK K+ +K A + E K ++E+K K
Sbjct: 855 TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKE-KHLMEKKNK 913
Query: 154 RQNEADKTPLKSSHENEQS----KKSKSSSETNPESQNSKTVS--KNCSQKDKKDSKNSK 207
+ + ++ + + E+ KK KS + + NSK + K S D +++ K
Sbjct: 914 QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 973
Query: 208 ------KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
KT E L T + +KD K+ K + ++ + ++ L+ + D+
Sbjct: 974 PLSLKEKTKDEPLKTPDGKEKD-KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1032
Query: 262 DAWLRNYSQNNSK---NYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN-- 316
+ ++ K N L T + + + K+ + + K +K+ ++++
Sbjct: 1033 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNC 1092
Query: 317 --VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
+K DK+K TES + E SK K+K KD ++
Sbjct: 1093 LELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTL 1152
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESE 412
G + ++S N S+N+ ++ ++ + + SE
Sbjct: 1153 GKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSE 1190
Score = 32.0 bits (71), Expect = 1.8
Identities = 26/102 (25%), Positives = 45/102 (44%), Gaps = 5/102 (4%)
Query: 367 PESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK 426
P+S T+ ++++ +DS ++K K K A ++S + E + EK
Sbjct: 2 PKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIA---SYSKTPKIERSDVSKEMKEKSSM 58
Query: 427 KDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS 468
K +N+E D+D+E +G KK K E KK +
Sbjct: 59 KRKLPFTISPSRNEER--DSDTEKEGPEKKKTKKEAGNKKST 98
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 94.0 bits (232), Expect = 4e-19
Identities = 136/599 (22%), Positives = 249/599 (41%), Gaps = 65/599 (10%)
Query: 60 RHDKRKLEEGQKPAHKWIRHSFRKILQ-WPPIYTAAREQTPFRHLYTSKTHLKKAEYKKS 118
RH RK + + H F K + + P +++Q P R LY+S + +
Sbjct: 378 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNK 437
Query: 119 KDEKGGTPLKKDSK---KKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKS 175
K + + + S + Y + E KQ + K K +N+ + EN++ K+
Sbjct: 438 KISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ------NKNKENQELKQE 491
Query: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKK------TNTEFLH--TKNNPKKDLKRS 227
K E + + +CS+K +++ K T+ H T +PK S
Sbjct: 492 KEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLS 551
Query: 228 KTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTK-- 285
+ + P+ + ++ L+ + Q D + +D + +S S K+ + +K
Sbjct: 552 EKQSTPLKQEHTKTCLSPGSSEMSLQPD--LVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
Query: 286 KD------TKKNAKKSSDAES---EDSKDAKKDSKKVKKNVKKDD-KKKDVKKDTESTDA 335
KD K NAK + S E+S K K K +KK K K+ +K+ +
Sbjct: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
Query: 336 ESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDD 395
E K + KD+ K+ ++ + D++ + + +S +TE + ++S L+K SK +
Sbjct: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFL-NMEHESLTLEKKSKLEK 728
Query: 396 KKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEES--TDADSE---- 449
KD K S+ +E K +K+ +K + + K +K + E+ TD DSE
Sbjct: 729 NIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL 788
Query: 450 ---------------PKGDSKKGKKD--EKKGKKDSKKDDKKKDAKKNAESTEMESDLEL 492
+ D +K +K E K K + + K+KD +K T E + ++
Sbjct: 789 GMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT-FEKEKKI 847
Query: 493 KKDKKHSKEKKGSKKDIKKDARKD---TESTDAEFDESSKTGFKTSTKIKGSDT--ESEE 547
K + K K+K + + K KD + T+ E K+ K + IK +D +S E
Sbjct: 848 KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKS--KNTAAIKKTDDREKSRE 905
Query: 548 SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
+ + K+K E + A SK + L K+ + + + + +EKG+ R +EK
Sbjct: 906 KMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 963
Score = 76.6 bits (187), Expect = 6e-14
Identities = 129/600 (21%), Positives = 224/600 (37%), Gaps = 111/600 (18%)
Query: 95 REQTPFRHLYTSKT----HL------KKAEYKKSKDEKGGTPLKKDSKK---KGGSYATN 141
RE+ FR ++ K HL K ++ EK TPLK++ K GS +
Sbjct: 516 REEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMS 575
Query: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK 201
+ + + T+ + + + +KS E+SK K E N+K ++ S +
Sbjct: 576 LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFEN 635
Query: 202 DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
KK + E K + K +R K + E E D + S+ F
Sbjct: 636 SDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS----AKELQRSVEF 691
Query: 262 DA--WLRNYSQN--------NSKNYSLKYTKYTKKDTK-KNAKKSSDAESEDSKDAKKDS 310
D W N+ ++ N ++ SL K +K + K+ K + + ++ K++
Sbjct: 692 DREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEER 751
Query: 311 KKVKKNVKK---DDKKKDVKKDTES--TDAESG--------------------------- 338
K+KK +K ++K KD+K++ E+ TD +S
Sbjct: 752 DKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQ 811
Query: 339 -----DSKD----------------ERKDTKKDKKKLKKDDKKKDTKKYPESTDT----- 372
+SK+ ERK +K+KK + +KD E D
Sbjct: 812 EKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKD 871
Query: 373 -----ESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESE------LESKESQKD 421
+ S+N K DD++K +K+ D E ESKE
Sbjct: 872 KLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLM 931
Query: 422 EKKDKKDSKTDNKKSV--KNDEESTDADSEPKGDSKK-----GKKDEKKGKKDSKKDDKK 474
EKK+K+ ++ KS KN E+ + D + K K+ K ++ KK S D K
Sbjct: 932 EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 991
Query: 475 KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKT 534
+K E D LK K+KK KDI + +D + + K +
Sbjct: 992 AQHEKPLSLKEKTKDEPLKTPDGKEKDKK--DKDIDRYKERDKHKDKIQINSLLKLKSEA 1049
Query: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKM---EGLESKRGFRMSSKKTTFNEK 591
S S+++ +P K+ +++ ++ +M + LE ++ + +K EK
Sbjct: 1050 DKPKPKSSPASKDT--RPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEK 1107
Score = 73.2 bits (178), Expect = 7e-13
Identities = 105/516 (20%), Positives = 206/516 (39%), Gaps = 64/516 (12%)
Query: 103 LYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTP 162
L+ + H KKSK EK KD K + + + + EE+ K + E++K
Sbjct: 709 LFLNMEHESLTLEKKSKLEKN----IKDDKSTKEKHVS--KERNFKEERDKIKKESEK-- 760
Query: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEF----LHTKN 218
S E+ K K E P ++S+ S S ++ + + + H K
Sbjct: 761 ---SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
Query: 219 NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSL 278
+ +K KRS+ I ++ + + +S+ + ++ + + +
Sbjct: 818 SKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL---- 873
Query: 279 KYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKD--TESTDAE 336
Y+ +T+K K+ K + A + + D +K +K+ + K DK+K K+ ES +
Sbjct: 874 -YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDR---KHDKEKPEKERHLAESKEKH 929
Query: 337 SGDSKDERKDTKKDKKKLKKDDKKKDTK--KYPESTDTESGDAKDARNDSRNLKKASKND 394
+ K+++ D + K K +K+KD + K +S D ES + ++++ K + +
Sbjct: 930 LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDG 989
Query: 395 DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS------ 448
+K + K ++ ++ E ++ ++KDKKD D K ++ +S
Sbjct: 990 NKAQHEKPLSLKEKTKDE--PLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1047
Query: 449 ---EPKGDSKKGKKDEKKGKKDSKKDD------------------------KKKDAKKNA 481
+PK S KD + +K DD K+K +K
Sbjct: 1048 EADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEK 1107
Query: 482 ESTEMESDLELKKD-KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
E + LELK K+ +K K+ + K +E TDA + + + S + +
Sbjct: 1108 ERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA-YTKEKQPKDAVSNRSQS 1166
Query: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
DT++ +L K + + ++ GL S+
Sbjct: 1167 VDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSR 1202
Score = 60.1 bits (144), Expect = 6e-09
Identities = 108/554 (19%), Positives = 209/554 (37%), Gaps = 97/554 (17%)
Query: 113 AEYKKSKDEKGGTPLKKDSKKKGGSYATNP----------ESKQ--IVEEKTKRQNEADK 160
+ Y+ +++G P KK +KK+ G+ + P E KQ ++ + T R N D
Sbjct: 95 SSYRTYSEKEG--PEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDS 152
Query: 161 TPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP 220
TP S KK+ SSS QKDK + +N + +
Sbjct: 153 TPNHPSQTTPAQKKTPSSSS---------------RQKDKVNKRNERGETPLHMAAIRGD 197
Query: 221 KKDLKR--SKTSN---------DPISEICSENSLNVDFLMLVGQSD--DESINFDAWLRN 267
K +K S +N P+ E C+ +V +++ +D + ++ D L +
Sbjct: 198 VKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHD 257
Query: 268 YSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327
+ + ++ ++ + N + ++++ + +K+ V D +
Sbjct: 258 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE---LLLKREVPLSDDDESY- 313
Query: 328 KDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYP--------ESTDTESGDAKD 379
D+E + + S DE D++ +K L + K+ K P E D + +
Sbjct: 314 TDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINK 373
Query: 380 ARNDSRNLKKASKNDD------------------------KKKDAKKITFSTDSESELES 415
+D L+K + ++ KK+ ++ +S+ S+ E+
Sbjct: 374 MIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEA 433
Query: 416 KESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKK 475
+++K +T N E + + KG K+ K++ K K++++ ++K
Sbjct: 434 LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNK-NKENQELKQEK 492
Query: 476 DAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTE------STDAEFDESSK 529
+ K+N T + + L +K +E K KD DT ST S
Sbjct: 493 EGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKD---DTSLHLFHISTGKSPKHSCG 549
Query: 530 TGFKTSTKIKGSDTE-------SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMS 582
K ST +K T+ SE SL + ES+ +S ++ + K +
Sbjct: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKE--KSK 607
Query: 583 SKKTTFNEKGEKAS 596
+K E GEK++
Sbjct: 608 HQKDFHLEFGEKSN 621
Score = 47.0 bits (110), Expect = 6e-05
Identities = 78/398 (19%), Positives = 153/398 (38%), Gaps = 36/398 (9%)
Query: 48 KSRPLKSQITVTRHDKRKLEEGQKPAHKWIRH---SFRKILQWPPIYTAAREQTPFRHLY 104
K +P K + D K+E K I+H S + L +E+ +
Sbjct: 819 KEKPEKRS-QIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 877
Query: 105 TSKTH-----------LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTK 153
T K H +KK + ++ EK K+ +K A + E K ++E+K K
Sbjct: 878 TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKE-KHLMEKKNK 936
Query: 154 RQNEADKTPLKSSHENEQS----KKSKSSSETNPESQNSKTVS--KNCSQKDKKDSKNSK 207
+ + ++ + + E+ KK KS + + NSK + K S D +++ K
Sbjct: 937 QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 996
Query: 208 ------KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
KT E L T + +KD K+ K + ++ + ++ L+ + D+
Sbjct: 997 PLSLKEKTKDEPLKTPDGKEKD-KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
Query: 262 DAWLRNYSQNNSK---NYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN-- 316
+ ++ K N L T + + + K+ + + K +K+ ++++
Sbjct: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNC 1115
Query: 317 --VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
+K DK+K TES + E SK K+K KD ++
Sbjct: 1116 LELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTL 1175
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESE 412
G + ++S N S+N+ ++ ++ + + SE
Sbjct: 1176 GKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSE 1213
Score = 32.7 bits (73), Expect = 1.1
Identities = 44/215 (20%), Positives = 90/215 (41%), Gaps = 20/215 (9%)
Query: 367 PESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK 426
P+S T+ ++++ +DS ++K K K A ++S + E + EK
Sbjct: 2 PKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIA---SYSKTPKIERSDVSKEMKEKSSM 58
Query: 427 KDSKTDNKKSVKNDEESTDADSEPKGDSKK-GKK--------DEKKGKKDSKKDDKKKDA 477
K +N+E +D DS+P S+ G++ EK+G + KK KK+
Sbjct: 59 KRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPE--KKKTKKEAG 116
Query: 478 KKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKD--TESTDAEFDESSKTGFKTS 535
K + + L + K+ + + + +D D+ + +++T A+ ++ + +
Sbjct: 117 NKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQK 175
Query: 536 TKIKGSDTESEESLYKP---GAKKKIDESDGTSAN 567
K+ + E L+ G K++ E AN
Sbjct: 176 DKVNKRNERGETPLHMAAIRGDVKQVKELISLGAN 210
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 94.0 bits (232), Expect = 4e-19
Identities = 119/559 (21%), Positives = 221/559 (39%), Gaps = 98/559 (17%)
Query: 107 KTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNP--ESKQIVEEKTK-RQNEADKTPL 163
K+ +KK E K+ K + DS S +++ +S+ EEK+K R+ + K
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSR 239
Query: 164 KSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKD 223
K E ++ KKSK S+ + E++N + Q + + FL K+ PK D
Sbjct: 240 KHKKEKKKRKKSKKSASSESEAENLEAQP----QSTVRPEEIPPIPENRFLMRKSPPKAD 295
Query: 224 LKRSKTSNDPISEICSE-NSLNVDFL--MLVGQSD--------------DESINFDAWLR 266
K K C+ NS + +LV +S S + D + R
Sbjct: 296 EKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRR 355
Query: 267 NYS--------------QNNSKNYSLKYTKYTKKDTKKNAK--------KSSDAES-EDS 303
+ + + +S +K K + K+N + K +D + +S
Sbjct: 356 SETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSES 415
Query: 304 KDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDT 363
+ K + +K K+ K + K++D+++++E D K K + K K K K++D+
Sbjct: 416 PNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDS 475
Query: 364 KKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEK 423
K + + ++ D N+K+ K D K ++ + S + +LESK ++ D
Sbjct: 476 KH--NRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHS 533
Query: 424 KDKKDSKTDNKKSVKND-------------EESTDADSEPKGDSKKGKKDEKKGKK---- 466
K K+ + +S + D E S D + S+ +D + K+
Sbjct: 534 KSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRY 593
Query: 467 ---------------------DSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGS 505
S+ D+++ ++++ S+E E KDK ++E K S
Sbjct: 594 REQEYRRRGRSRSRERRTPPGRSRSKDRRR-RRRDSRSSEREESQSRNKDKYRNQESKSS 652
Query: 506 KKDIKKDARKDTESTDAEFDESSKTGFKTS-------TKIKGS--DTESEESLYKPGAKK 556
+ ++ K S + + S+ + K + +KIK S D E + S+ K +
Sbjct: 653 HRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDE 712
Query: 557 KIDESDGTSANSKMEGLES 575
KI S N K +G E+
Sbjct: 713 KI-RSSVEKENQKSKGQEN 730
Score = 77.8 bits (190), Expect = 3e-14
Identities = 98/516 (18%), Positives = 203/516 (39%), Gaps = 54/516 (10%)
Query: 140 TNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKD 199
T+ SK E + E E ++ K S SSS ++ +S +S + D
Sbjct: 159 TDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSD 218
Query: 200 KKDSKNSKKTNTEFLHTKNN--PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDE 257
+ + K + H KN+ KK+ K+ K S S +L V +
Sbjct: 219 SESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIP 278
Query: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVK--- 314
I + +L S + K + +++ + N S A + + +K+K
Sbjct: 279 PIPENRFLMRKSPPKADEKERK-NRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRG 337
Query: 315 ---KNVKKDDKKKDVKKDTESTD-------------AESGD-----SKDERKDTKKDKK- 352
+ +D + +E+ SG+ K E + K++++
Sbjct: 338 PRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRS 397
Query: 353 ----KLKKDDKKKDTKKYPESTDTESGDAKDARNDS--RNLKKASKNDDKKKDAKKITFS 406
K +K ++ + P + + KD +++S R++++ S+ DDK K+ K+
Sbjct: 398 PVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKN--KVKKR 455
Query: 407 TDSESELESKESQKDEKKDKKDSKTDNKK-----------SVKNDEESTDADSEPKGDSK 455
S+S +SKE K +++D K ++ + K+ +VK E+ +D+ + + S+
Sbjct: 456 AKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSR 515
Query: 456 KGKKDEKKGKKDSKKD-DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSK-KDIKKDA 513
+K ++ K ++ D K K+ + A+S E D+ K +S+ ++ S+ +D +
Sbjct: 516 SKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRV 575
Query: 514 RKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKID----ESDGTSANSK 569
R T D + + + +G + S E PG + D D S+ +
Sbjct: 576 RSRTHDRDRSRSKEYHRYREQEYRRRGR-SRSRERRTPPGRSRSKDRRRRRRDSRSSERE 634
Query: 570 MEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSRE 605
+K +R K++ ++ ++ SR+
Sbjct: 635 ESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRD 670
Score = 75.1 bits (183), Expect = 2e-13
Identities = 103/543 (18%), Positives = 219/543 (40%), Gaps = 75/543 (13%)
Query: 48 KSRPLKSQITVTRH--DKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYT 105
K R K + +H +K+K ++ +K A S + L+ P T E+ P +
Sbjct: 228 KKRKKKHRKNSRKHKKEKKKRKKSKKSASS---ESEAENLEAQPQSTVRPEEIP--PIPE 282
Query: 106 SKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKS 165
++ ++K+ K + E+ +++ + + ++++ ++ R+ +
Sbjct: 283 NRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYR 342
Query: 166 SHENEQSKKSKSSSETNPE-SQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL 224
+ +S+ SET P Q + + ++ K K E + +P +
Sbjct: 343 TPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVK 402
Query: 225 KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYT 284
+R T + +SE S N N + D +S + + +R S+ + K Y K K
Sbjct: 403 ERKITDHRNVSE--SPNRKNEKEKKV---KDHKSNSKERDIRRNSEKDDK-YKNKVKKRA 456
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVK--------KNVKKDDKKKDVK-KDTESTDA 335
K ++ +K+ S ++ DSK + + K+++ +NVK+ +K+ D K KD E + +
Sbjct: 457 KSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRS 516
Query: 336 ESGDSKDERKDTKKDKKKLKKDDKKK-------DTKKYPESTDTESGDAKDARNDSRNLK 388
+ + E K + D K K+ D++ D K S ++ + + +R+ SR ++
Sbjct: 517 KEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVR 576
Query: 389 KASKNDDKKKDAKKITFSTDS--------------------------------ESELESK 416
+ + D+ + + + SE E
Sbjct: 577 SRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREES 636
Query: 417 ESQKDEKKDKKDSKTDNKKSVKNDEE-----STDADSEPKGDSKKGKKDEK---KGKKDS 468
+S+ +K ++SK+ ++K E+ S D +S KK +D+ K K+ S
Sbjct: 637 QSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSS 696
Query: 469 KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESS 528
+ ++ K KN E ++ S +E K +++ KG + D + K + + +
Sbjct: 697 QDNELKSSMLKNKEDEKIRSSVE-----KENQKSKGQENDHVHEKNKKFDHESSPGTDED 751
Query: 529 KTG 531
K+G
Sbjct: 752 KSG 754
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/467 (17%), Positives = 196/467 (41%), Gaps = 46/467 (9%)
Query: 13 TYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQK- 71
+Y + ++ S RK + P+ + + +SR + H +++++ Q+
Sbjct: 319 SYQRRLLVTRSGRKIKGRG------PRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRM 372
Query: 72 ---PAHKWIRHSFRKIL-----QWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKG 123
+WI+ ++ Q P+ R+ T R++ S + E KK KD K
Sbjct: 373 RVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKE-KKVKDHKS 431
Query: 124 GTPLK--KDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSET 181
+ + + + +K Y + + + ++K + ++ S H + K+ +S S+
Sbjct: 432 NSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKG 491
Query: 182 NPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSEN 241
+ +N K K K K ++ K ++ L +K+N + D +SK + E
Sbjct: 492 R-DHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSN-EHDHSKSKEKDRRAQSRSREC 549
Query: 242 SLNVDFLMLVGQSDDESINFDAW--LRNYSQNNSKNYSLKYTKYTKKDTKKNAK-KSSDA 298
+ ++ + S + D +R+ + + ++ S +Y +Y +++ ++ + +S +
Sbjct: 550 DITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRER 609
Query: 299 ESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKL-KKD 357
+ + KD ++ ++ D+ S++ E S+++ K ++ K +K+
Sbjct: 610 RTPPGRSRSKDRRRRRR-------------DSRSSEREESQSRNKDKYRNQESKSSHRKE 656
Query: 358 DKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKE 417
+ + + + Y +S D N S N ++ + D+ +K S D+E + +
Sbjct: 657 NSESEKRMYSKSRD---------HNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLK 707
Query: 418 SQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKG 464
+++DEK K + K + ++ + + + +S G ++K G
Sbjct: 708 NKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG 754
Score = 47.0 bits (110), Expect = 6e-05
Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 7/105 (6%)
Query: 392 KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT-------DNKKSVKNDEEST 444
K D K ++ + E +SK ++++K+ K S + D+ ++ +S+
Sbjct: 158 KTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSS 217
Query: 445 DADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESD 489
D++S + SKK KK +K + KK+ KK+ K + S+E E++
Sbjct: 218 DSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAE 262
Score = 43.1 bits (100), Expect = 8e-04
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 19/106 (17%)
Query: 440 DEESTDADSEPKGD-----------SKKGKKDEKKGKKDSKK-------DDKKKDAKKNA 481
+ + TDA S+P + K KK+EKK K S D D++ ++
Sbjct: 155 ENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSS 214
Query: 482 ESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDES 527
+S++ ES E K K+ K +K S+K KK+ +K +S + ES
Sbjct: 215 DSSDSESATEEKSKKRKKKHRKNSRKH-KKEKKKRKKSKKSASSES 259
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 93.2 bits (230), Expect = 7e-19
Identities = 126/556 (22%), Positives = 209/556 (37%), Gaps = 60/556 (10%)
Query: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKR 154
+++ P R + T TH +K + K+ EK P KK + K+ PE+K + +E+ K+
Sbjct: 150 KQEKPERKIQTKVTHKEKEKGKEKVREK-EKPEKKATHKEKIEKKEKPETKTLAKEQ-KK 207
Query: 155 QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKD---SKNSKKTNT 211
A+K+ K+ E + K+ K + KT SK ++DK+ SK+ +K
Sbjct: 208 AKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQY 267
Query: 212 EFLHTKNN--PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYS 269
F + DLK ++ P + S + + + E
Sbjct: 268 AFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE------------ 315
Query: 270 QNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSK-----------KVKKNVK 318
K K T TKK K++ KK S+ E+ + K+ K + K
Sbjct: 316 ---KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAK 372
Query: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTK-----KDKKKLKKDDKKKDTKKYPESTDTE 373
KD+KK+D KK + + E K + K K K KK K K E E
Sbjct: 373 KDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432
Query: 374 SG-----DAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES--------ELESKESQK 420
G A + + + K + K+K K + D E KE +
Sbjct: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP 492
Query: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
+ KKD+K SK + K + + +P+ KK K K K D K K
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
Query: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG 540
+ E LK+ K + EK K KK ++ E + D+ T TS +
Sbjct: 553 SHGKPEEK--VLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTES 610
Query: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLE------SKRGFRMSSK-KTTFNEKGE 593
++E S + K + +++ E L+ +++ R+S + K
Sbjct: 611 GKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKA 670
Query: 594 KASTGRVPPSREKPPL 609
K T V P+++K P+
Sbjct: 671 KEGTEDVSPTKQKSPI 686
Score = 80.5 bits (197), Expect = 4e-15
Identities = 123/538 (22%), Positives = 210/538 (39%), Gaps = 100/538 (18%)
Query: 110 LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN 169
L+K E K K EK P +K K ++ + K+ V EK K + K++H+
Sbjct: 138 LRKKEIHKDKTEKQEKPERKIQTKV--THKEKEKGKEKVREKEKPEK-------KATHKE 188
Query: 170 EQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKT 229
+ KK K ++T + Q ++ +K KK+ K K+ K K + KT
Sbjct: 189 KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKV-----KQTAAKVKEVQKT 243
Query: 230 SNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTK 289
+ P + E + S E + A+ R Y + + D K
Sbjct: 244 PSKPKEKEDKEKA---------AVSKHEQKDQYAFCR---------YMIDI--FVHGDLK 283
Query: 290 KNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKK 349
+ + ++ K+ +KKK KK T T
Sbjct: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET---------------- 327
Query: 350 DKKKLKKDDKKKDTKKYP--ESTDTESGDAKDARNDSRNL--KKASKNDDKKKDAKKITF 405
KK +K+D KK ++K + E G A + + + + + A+K D+KK+D+KK
Sbjct: 328 --KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK--- 382
Query: 406 STDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGK------- 458
T +E+E + +K EKK+K + K E S +D + K +++ K
Sbjct: 383 -TKKPAEVEQPKGKKQEKKEKHVEPAKSPKK----EHSVPSDKQVKAKTERAKEEIGAVS 437
Query: 459 -KDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEK-KGSKKDIKKDARKD 516
K GKK+ K + + +S + S L+ K+ K +EK S K+ + + +KD
Sbjct: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
Query: 517 TESTDAEFDESSKTGFKTSTK---IKGSDTESEESLYKPGAKKKIDES-----------D 562
++ SK G + K ++G E E K AK I E +
Sbjct: 498 --------EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPE 549
Query: 563 GTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPK 620
T ++ K E K+ ++ +KT + +KA RE P + +P P+PK
Sbjct: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAE----HREREPPSIKTDKPK-PTPK 602
Score = 63.5 bits (153), Expect = 6e-10
Identities = 94/446 (21%), Positives = 184/446 (41%), Gaps = 59/446 (13%)
Query: 203 SKNSKKTNTEFLHTKN-----NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDE 257
++ + T T + +KN +P K LKR+ T D ++ S + + +++ S
Sbjct: 6 AEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTE-DIVTTFSSPAAWLLVIALIITWSAVA 64
Query: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNV 317
+ FD L +Y KN+S D K + + E++ D + ++
Sbjct: 65 IVMFD--LVDY-----KNFSASSIAKIGSDPLKLVRDAM----EETTDWIYGFFSLLSDI 113
Query: 318 KKDDKKKDVKKDTESTDAESGDSKDERKDTKKDK-KKLKKDDKKKDTKKYPESTDTESGD 376
+ ++D D ++ E + +K+ KDK +K +K ++K TK T E
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKV----THKEKEK 169
Query: 377 AKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKS 436
K+ + +K + + +K + +K T ++ + ++K ++K E+K KK+ K ++
Sbjct: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEK 229
Query: 437 VKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDA-------------KKNAES 483
VK + + K SK +K++K+ SK + K + A K +S
Sbjct: 230 VK--QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQS 287
Query: 484 TEMESDLELKKDKKHS------KEKKGSKKDIKKDARKDT---ESTDAEFDESSKTGFKT 534
+ L ++ + + +EK+G KK +K +T E D + +T
Sbjct: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
Query: 535 STKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEK 594
K G +E+++ K A+ + + K + ++K+ + K EK EK
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDE-----KKEDSKKTKKPAEVEQPKGKKQEKKEK 402
Query: 595 ASTGRVPPSREKPPLPACEPSLPSPK 620
V P++ P E S+PS K
Sbjct: 403 ----HVEPAKS----PKKEHSVPSDK 420
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 89.4 bits (220), Expect = 1e-17
Identities = 112/514 (21%), Positives = 204/514 (39%), Gaps = 90/514 (17%)
Query: 121 EKGGTPLKKDSKKKGGSYATNPESKQIVE-EKTKRQNEADKTPLKSSHENEQSKKSKSSS 179
E+ G KDS++ G + N SK+++ E+ KR +E + E E + + +
Sbjct: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
Query: 180 ETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICS 239
+ E ++ ++ ++++ + + S H + +K ++ N ++ I +
Sbjct: 176 Q---EGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVT-IQA 231
Query: 240 ENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAE 299
E+++ +DF DD L T K T A K D +
Sbjct: 232 EDAITLDF-----DGDD---------------------LLETGKNVKITDSEASKPKDGQ 265
Query: 300 SEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
++ +K+SK + N D KK+ D GD + K+ ++ KK + DK
Sbjct: 266 DAIAQSPEKESKDYEMNANHKDGKKE--------DCVKGDPVE--KEARESSKKAESGDK 315
Query: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ 419
+KDT K S+ SG AK + +S++ K +SK+D + + + +++ S S
Sbjct: 316 EKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSS 375
Query: 420 KDEKKDKKD-----SKTDNKKSVKNDEE-------------STDAD-------------- 447
+ D K+ K + K V N ST+
Sbjct: 376 NTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQ 435
Query: 448 ----SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK 503
+ KGD K E K + D K + KKN ++ +KK+ EK+
Sbjct: 436 LISVEKVKGDPSK---KEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKE-----EKR 487
Query: 504 GSKKDIKKDARKDTESTDAEFDESSKTGF--KTSTKIKGSDTESEESLYKPGAKKKIDES 561
S+K KK++ KDT+ + + DE + G +TS IK S+ + S PG +D++
Sbjct: 488 SSEKSEKKES-KDTKKIEGK-DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQT 545
Query: 562 DGTSANSKMEG-LESKRGFRMSSKKTTFNEKGEK 594
G G E G ++ + ++K +K
Sbjct: 546 KGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
Score = 65.9 bits (159), Expect = 1e-10
Identities = 90/410 (21%), Positives = 156/410 (38%), Gaps = 90/410 (21%)
Query: 109 HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHE 168
++K + + SK + G + + +K+ Y N K +E + + +K +SS +
Sbjct: 250 NVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKK 309
Query: 169 NEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSK 228
E K K + + P S + +K+ S K+ KDSK S K D K S
Sbjct: 310 AESGDKEKDTLKKGPSSTGASGQAKS-SSKESKDSKTSSK--------------DDKGST 354
Query: 229 TSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDT 288
+S S ++N W+ S N
Sbjct: 355 SSTSGSSGSSTKN---------------------IWVSGLSSNT---------------- 377
Query: 289 KKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK----KDVKKDTESTDAESGDSKDER 344
K++D ++ K K S KV N + K + TE + + + E
Sbjct: 378 -----KAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTEL 432
Query: 345 KDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKIT 404
+K+K D KK+ KK ND ++ ++S DKK + + +
Sbjct: 433 HGQLISVEKVKGDPSKKEMKK---------------ENDEKSSSRSS--GDKKNTSDRSS 475
Query: 405 FSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSE--PKGDSKKGKKDEK 462
+ S + E + S+K EKK+ KD+K K KND ++ SE K + KK +
Sbjct: 476 KTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKS 535
Query: 463 KGKK---DSKKDDKKKDAKK------NAESTEME-SDLELKKDKKHSKEK 502
G D K D + +++ + S E E + L+ K+DK + +++
Sbjct: 536 PGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKE 585
Score = 43.1 bits (100), Expect = 8e-04
Identities = 59/258 (22%), Positives = 111/258 (43%), Gaps = 36/258 (13%)
Query: 346 DTKKDKKKLKKDDKKKDT---KKYPESTDTESGDAKDAR----NDSRNLKKASKNDDKKK 398
D K + K+ D T + ++ + E GD + D+ N KK +K KK
Sbjct: 29 DLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPN-KKPTKGKGKKH 87
Query: 399 DAKKITFSTDSESELESK----ESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDS 454
+A +++ E + K E+Q+ ++D D D+++ +N+EE+ + +
Sbjct: 88 EADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEE 147
Query: 455 KKGKKD--EKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKD 512
K + E +G +D +K+D + + A+ E ++ L + ++ EK+GS +
Sbjct: 148 NKRAHELIEAEGIEDIEKEDIESQ-EIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHT 206
Query: 513 ARKDTES----TDAEFDESSKTGFKTSTKIKGSDTES----EESLYKPGAKKKIDES--- 561
A ++ E+ +AE D S T I+ D + + L + G KI +S
Sbjct: 207 AHEEMEAHTTVKEAEDDNISVT-------IQAEDAITLDFDGDDLLETGKNVKITDSEAS 259
Query: 562 ---DGTSANSKMEGLESK 576
DG A ++ ESK
Sbjct: 260 KPKDGQDAIAQSPEKESK 277
Score = 42.0 bits (97), Expect = 0.002
Identities = 77/483 (15%), Positives = 198/483 (40%), Gaps = 66/483 (13%)
Query: 102 HLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKT 161
HL+ ++ H + +K K G P KK+ KK+ +EK+ ++ DK
Sbjct: 426 HLHRTELHGQLISVEKVK----GDPSKKEMKKEN-------------DEKSSSRSSGDK- 467
Query: 162 PLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK--DSKNSKKTNTEFLHTKNN 219
+N + SK+ + E + S S+ KD K + K+ K N T +
Sbjct: 468 ------KNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSES 521
Query: 220 PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESI---NFDAWLRNYSQNNSKNY 276
KK ++ + S+ + + D + E I + + + + K+Y
Sbjct: 522 IKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDY 581
Query: 277 SLKYTKYTKKDTKKNAKK------------SSDAESEDSKDAKKDSKKVKKNVKKDDKKK 324
K +K ++ ++ E ++ +++ +++ + +++ ++++
Sbjct: 582 RRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERI-RIIREREERE 640
Query: 325 DVKKDTESTDAESGDSKDERKDTKK-DKKKLK-KDDKKKDTKKYPESTDTESGDAKDAR- 381
++++ E + E + ER + ++ ++++++ + +++K+ ++ + + R
Sbjct: 641 RLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRY 700
Query: 382 -NDSRNLKKASKNDDKKKD------AKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
+ RN K ++ D ++D KK++ TD+ S S++ + + D + +
Sbjct: 701 EQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHR---E 757
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK--------KDAKKNAESTEM 486
+ + + + S + D G+ + KK + ++++D D+++N E
Sbjct: 758 RGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRN-EPPPP 816
Query: 487 ESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGS-DTES 545
++L + D++ + ++ ++ + R D + TS K +GS T+
Sbjct: 817 RNELR-ESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDK 875
Query: 546 EES 548
E+
Sbjct: 876 RET 878
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 89.4 bits (220), Expect = 1e-17
Identities = 101/497 (20%), Positives = 203/497 (40%), Gaps = 63/497 (12%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHE-- 168
K +KD+ L + + G + P+ + ++K K++ + D+ + E
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL 65
Query: 169 NEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSK 228
+ +++ K+ ET + S+ KK + KK + + ++ KD K K
Sbjct: 66 SLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKK 125
Query: 229 TSNDPISEICSENSLNVDFLMLVGQSDDESIN-FDAWLRNYSQNNSKNYS-LKYTKYTKK 286
T+ + M G DD+ N + +Q ++K + + + K
Sbjct: 126 TAKPKVE-------------MYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
Query: 287 DTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESG-DSKDERK 345
K+ ++ +S ES D D S+K +K +K+ +++ E DA + ++K
Sbjct: 173 KIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
Query: 346 DTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITF 405
KK++++ K+D++K +K E + E+G + D K++ + +++ K+T
Sbjct: 233 AEKKERERKKRDEEKAKLRKLKEKEELETG-----KKDQSKQKESQRKFEEETVKSKVTV 287
Query: 406 STDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKD--EKK 463
T E K E T A+ + +GD KK KD +KK
Sbjct: 288 DTGVIPASEEKA-----------------------ETPTAAEDDNEGDKKK--KDKKKKK 322
Query: 464 GKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAE 523
G+K+ K+ +KKK K E+ +LK++++ K + +++ K E +A+
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE-------EEERIKRLEELEAK 375
Query: 524 FDESSKTGFKTSTKIKGSDTESEESLYKPG---AKKKIDESDGTSANSKM---EGLESKR 577
E + + + K + E +E L K G K + + A K+ +G+E
Sbjct: 376 RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPS 435
Query: 578 GFRMSSKKTTFNEKGEK 594
+ K+ + +K K
Sbjct: 436 KDSLPKKRPIYEDKKRK 452
Score = 86.7 bits (213), Expect = 6e-17
Identities = 101/452 (22%), Positives = 195/452 (43%), Gaps = 57/452 (12%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQN---EADKTPLKSSH 167
K+ E +KSK +K KK+ KK+ + + K++ E + Q + + +K +
Sbjct: 33 KEQEPQKSKGKK-----KKEKKKQ--DFDEDDILKELEELSLEAQGIKADRETVAVKPTE 85
Query: 168 ENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK--KTNTEFLHTKNN------ 219
NE+ SK + + + + + + KDSK+ K K E ++
Sbjct: 86 NNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK 145
Query: 220 -PKKDLKRSKTSNDPI--SEICSENSLNVDFLMLV---GQSDDESINFDAWLRNYSQNNS 273
PKK +++ SN SE +NS + + G+S DES F R + N
Sbjct: 146 LPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF-LQSRKGQKKNQ 204
Query: 274 KNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTEST 333
KN + +D + K + A+ KK KK ++ K+D++K ++K E
Sbjct: 205 KNKPGPNIESGNEDDDASFKIKTVAQ-------KKAEKKERERKKRDEEKAKLRKLKEKE 257
Query: 334 DAESGDSKDERKDTKKDKKKLKKDDKKK---DTKKYPEST----------DTESGDAKDA 380
+ E+G KD+ K + +K ++ K K DT P S D GD K
Sbjct: 258 ELETG-KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK 316
Query: 381 RNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKD--SKTDNKKSVK 438
+ +K K +KKK K T E+ + KE ++ +K+++++ + + ++ +
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376
Query: 439 NDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST---------EMESD 489
+EE + + + K+ ++ E+ K+ +++A+ AE+T E+ S
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436
Query: 490 LELKKDKKHSKEKKGSKKDIKKDARKDTESTD 521
L K + ++KK K + ++++ +ES +
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESME 468
Score = 82.0 bits (201), Expect = 2e-15
Identities = 99/478 (20%), Positives = 206/478 (43%), Gaps = 40/478 (8%)
Query: 116 KKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKT-----KRQNEAD-----KTPLKS 165
K K KG +K +KK GS SK+I E + +E+D + K
Sbjct: 145 KLPKKAKGKA--QKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKK 202
Query: 166 SHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP----- 220
+ +N+ +S +E + S KTV++ ++K +++ K + + K
Sbjct: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETG 262
Query: 221 KKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKY 280
KKD + K S E ++ + VD ++ + +E + ++ + K K
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVI--PASEEKAETPTAAEDDNEGDKKKKDKKK 320
Query: 281 TKYTKKDTKKNAKKS-SDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK-KDTESTDAESG 338
K K++ +K KK S A + ++A K+ ++ K++++++ + ++ E+ E
Sbjct: 321 KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
Query: 339 DSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARN--DSRNLKKASKN--- 393
+ E+++ KK K+K +K+ KK+ K +S A+ ++ ++ SK+
Sbjct: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP 440
Query: 394 ------DDKKKDAKKITFSTDSESELESKE--SQKDEKKDKKDSKTDNKKSVKNDEESTD 445
+DKK+ KKI +S+ ES E + + + K + V+ +EE D
Sbjct: 441 KKRPIYEDKKR--KKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEE-D 497
Query: 446 ADSEPKGDSKKGKKDEKKGKKDSKK---DDKKKDAKKNAESTEMESDLELKKDKKHSKEK 502
+ D + DE+ K + K + K+ ++ E E E D E +++++ E
Sbjct: 498 TEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES 557
Query: 503 KGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDE 560
+GS+ D + + D + + D+ + ++ D ++E AK++I++
Sbjct: 558 EGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615
Score = 76.3 bits (186), Expect = 8e-14
Identities = 73/310 (23%), Positives = 121/310 (39%), Gaps = 21/310 (6%)
Query: 312 KVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTK----KDKKKLKKDDKKKDTKKYP 367
K +KN +D K D+ D + + E + E++ K K K+K K+D + D K
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 368 ESTDTESGDAKDAR-----NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE 422
E E+ K R + N ++ + DKKK +K + + +S++ E
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQK-----GKKQSFDDNDSEELE 117
Query: 423 KKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE 482
KD K KT K D D KGK + K D ++D+ K
Sbjct: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKER 177
Query: 483 STEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD 542
S S + + + +KG KK+ K + ES + + D S K K + +
Sbjct: 178 SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
Query: 543 TESEESLYKPGAKKKIDESD--GTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV 600
E ++ + +K+ E + T + + ES+R F + K+ TG +
Sbjct: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVT-----VDTGVI 292
Query: 601 PPSREKPPLP 610
P S EK P
Sbjct: 293 PASEEKAETP 302
Score = 72.8 bits (177), Expect = 9e-13
Identities = 89/361 (24%), Positives = 140/361 (38%), Gaps = 75/361 (20%)
Query: 289 KKNAKKSSD------------AESEDSKDAKKDSKKVKKNVKKDDKKK------DVKKDT 330
KK KS D AE E + AK+ + K KK +KKK D+ K+
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 331 ESTDAESGDSKDER-----KDTKKDKKKLKKDDKKKDTKKYPEST--DTESGDAKDARND 383
E E+ K +R K T+ ++++ DKKK +K + + D +S + +D +
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
Query: 384 SRNLKKAS----KNDDKKKDAKKITFSTDSESELESKE---SQKDEKKDKK--------- 427
S+ K D D K+ +++ +K+ S++DE KK
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
Query: 428 ------------DSKTDNKKSVKN------DEESTDADSEPKGDSKKGKKDEKKGKKDSK 469
S+ KK+ KN + + D D+ K + KK EKK ++ K
Sbjct: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK 242
Query: 470 KDDKKKDAKKNAESTEMESDLELKKDKKHSKE--KKGSKKDIKKDARKDT---------- 517
+D++K +K E E+E+ KKD+ KE +K ++ +K DT
Sbjct: 243 RDEEKAKLRKLKEKEELETG---KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299
Query: 518 -ESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
T AE D K K KG E E+ K +K + A K E K
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQK 359
Query: 577 R 577
R
Sbjct: 360 R 360
Score = 72.8 bits (177), Expect = 9e-13
Identities = 94/454 (20%), Positives = 191/454 (42%), Gaps = 71/454 (15%)
Query: 90 IYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
I T A+++ + K +KA+ +K K+++ KKD K+ ES++ E
Sbjct: 225 IKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ-------KESQRKFE 277
Query: 150 EKTKRQN------------EADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQ 197
E+T + E +TP + +NE KK K + E + + +
Sbjct: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE------KE 331
Query: 198 KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDE 257
K K SK + K E L K++ +R K + + E + + ++E
Sbjct: 332 KKKGPSKATVKAMQEALAKL---KEEEERQKREEEERIKRLEE--------LEAKRKEEE 380
Query: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDA-----ESEDSKDAKKDSKK 312
+ + R + + LK +++ A+ ++A +++ + KDS
Sbjct: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP 440
Query: 313 VKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDT 372
K+ + +D K+K + + ES + E + + +++ +K+ P +
Sbjct: 441 KKRPIYEDKKRKKIPQQLESKEVS------ESMELCAAVEVMEQGVPEKEETPPPVEPEE 494
Query: 373 ESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTD 432
E D +DA D AS + +K + K+ +E KE+ ++E++++++ + D
Sbjct: 495 EE-DTEDAGLDDWEAM-ASDEETEKVEGNKV--------HIEVKENPEEEEEEEEEEEED 544
Query: 433 NKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLEL 492
E ++ + E +G+S+ + DE+ K +KD K KK S EM SD E
Sbjct: 545 ---------EESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK--PSKEMSSDSEY 593
Query: 493 KKDKKHSKEKKG---SKKDIKKDARKDTESTDAE 523
D +KE++ +K+ I+K + +++ + E
Sbjct: 594 DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTE 627
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 88.6 bits (218), Expect = 2e-17
Identities = 125/596 (20%), Positives = 247/596 (41%), Gaps = 114/596 (19%)
Query: 39 KPLQRGTNDKSRP--LKSQITVTRHDKRKLEEGQK--PAHKWIRHSFRKILQWPPIYTAA 94
K ++GT +K +P K ++ +G + P + I H + I Q T
Sbjct: 945 KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1004
Query: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGT-PLKKDSKKKGGSYATNPESKQIVEEKTK 153
+++ TSK + ++Y + KG + +D K K G+Y + +++ + ++
Sbjct: 1005 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1064
Query: 154 RQ------------------NEADKT----------PLKSSHENEQSKKSKSSSETNPES 185
++ N +DK L S ++ + SSS+ S
Sbjct: 1065 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1124
Query: 186 QNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSN------DPISEICS 239
+++K + S K K KK N+ TK + D+ S +S+ + I E S
Sbjct: 1125 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK-QADITSSSSSDIEDDDQNSIGEGSS 1183
Query: 240 ---------ENSLNVDFLMLVGQSDDESINFDAWLR---NYSQNNSKNYSLKYTKYTKKD 287
EN + S DE+++ + + N+ +N K K ++
Sbjct: 1184 DEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK--KMLLEE 1241
Query: 288 TKKNAKKSSDAESEDSKDA--KKDSKKVKKNVKKDDKKKDVKKDTESTDAES-------- 337
K N D S+D + K+ K+ ++N ++ K V +++S ES
Sbjct: 1242 IKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHR 1301
Query: 338 ----------GDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTD-TESGDAKDA------ 380
G+S +E+K K+ K++K +++K + + E +D ESG +++
Sbjct: 1302 LLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDE 1361
Query: 381 -RNDSRNLKKASKNDD-----KKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
R +R+ KKA ++ +KK ++I DS SE +S +++E+K++++
Sbjct: 1362 QRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEE------ 1415
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKK 494
+ +EE + + + DSK K KK +K KDDK + +NA E E
Sbjct: 1416 ---EEEEEEEEEEEDENDDSKSPGKGRKKIRK-ILKDDKLRTETQNALKEEEE------- 1464
Query: 495 DKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTK-IKGSDTESEESL 549
+ K+ ++++ +++ ++ E +++S T +TK + D E++E L
Sbjct: 1465 -----RRKRIAEREREREKLREV----IEIEDASPTKCPITTKLVLDEDEETKEPL 1511
Score = 85.9 bits (211), Expect = 1e-16
Identities = 114/497 (22%), Positives = 206/497 (41%), Gaps = 59/497 (11%)
Query: 93 AAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNP--ESKQIVEE 150
++ T ++T+ L + + KD+KG K+ S G + T +K +
Sbjct: 709 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR--KRKSSTSGSDFDTKKGKSAKSSIIS 766
Query: 151 KTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTN 210
K KRQ +++ S++++E K+ KS S+ K + +D K+SKK
Sbjct: 767 KKKRQTQSES----SNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM 822
Query: 211 TEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQ 270
H K KTS + S+ F G D ++ + LR+
Sbjct: 823 DNQGH---------KNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME--LRD--- 868
Query: 271 NNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDS-KDAKKDSKKVKKNVKKDDKKKDVKKD 329
+ K+ A S+D + S K+ S +V+K + +K K +K
Sbjct: 869 --------------RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 914
Query: 330 TESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKK 389
T + G S K KKD+ +D KK +KK E S K + +
Sbjct: 915 T-CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYES 973
Query: 390 ASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKND--EEST-DA 446
+S +K + ++I ++++ + ++K K KT KK +D E+ST
Sbjct: 974 SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG 1033
Query: 447 DSEPKGDSKKGK-----KDEKKGKKDSKKDDKKKD-AKKNAESTEME------SDLELKK 494
DS + KK K +++K+ K K K++D + + E M+ SD LK+
Sbjct: 1034 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR 1093
Query: 495 DKKHSKEKKGSKKDIKKDARKDTESTDAE--FDESSKTGFKTSTKIKGSDT-ESEESLYK 551
+ + SK++ K+ + + S+DAE +++ K +TS+K K E + + +
Sbjct: 1094 IELRERRNLSSKRN-TKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1152
Query: 552 PGAKKKIDESDGTSANS 568
K+K ++D TS++S
Sbjct: 1153 TSTKRK--QADITSSSS 1167
Score = 84.0 bits (206), Expect = 4e-16
Identities = 108/495 (21%), Positives = 198/495 (40%), Gaps = 59/495 (11%)
Query: 148 VEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK 207
+ EK +++++D+T S + +QSKK + + P K + + D
Sbjct: 926 IAEKFLKKDQSDET---SEDDKKQSKKG-TEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 208 KTNTEFLH-------TKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESIN 260
E H KN K+SK D S+ E S + G S D S +
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 261 FDAWLRNYSQNNSK-----NYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
+ Y + + S K + DT+K + K S D K K+ + ++
Sbjct: 1042 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRLKRIELRERR 1100
Query: 316 NVKKDDKKKDVKKDTESTDAE--SGDSKDERKDTKKDKKKLKKDDKKKDT------KKYP 367
N+ K+++ + S+DAE S D+K +++ T KK + +KK+++ +K
Sbjct: 1101 NLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1160
Query: 368 ESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK-------ITFSTDSESELESKESQK 420
+ T + S D +D +D ++ + S ++ K K + F S E SK
Sbjct: 1161 DITSSSSSDIED--DDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1218
Query: 421 DEKKDKKDSKTDNK--KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK 478
D D+ +N+ K + +E + S+ G S ++ KK +++ +
Sbjct: 1219 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1278
Query: 479 KNAESTEMESDLELKKDKKH---------------SKEKKGSK----KDIKKDARKDTES 519
KN ++E +SD E K ++ S E+K +K K++K R+ S
Sbjct: 1279 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1338
Query: 520 TDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGF 579
D+E + ++G S++E E+ AKK E + S K + K
Sbjct: 1339 EDSEDSDFQESGVSEEV----SESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1394
Query: 580 RMSSKKTTFNEKGEK 594
SS+ + +E+ E+
Sbjct: 1395 DSSSENKSNSEEEEE 1409
Score = 72.0 bits (175), Expect = 2e-12
Identities = 135/633 (21%), Positives = 234/633 (36%), Gaps = 85/633 (13%)
Query: 47 DKSRPLKSQITVTRHDKRKLEEGQKPA---HKWIRHSFRKILQWPPIYTAAREQTPFRHL 103
+K + K + + K +G+KP K I S K+ +R+Q H+
Sbjct: 386 NKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKL---------SRKQVDSEHM 436
Query: 104 YTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESK---QIVEEKTKRQNEADK 160
+ + E +++ GG K D K++ N IV + + +
Sbjct: 437 HQNVP----TEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFE 492
Query: 161 TPLKSSHENEQSKKSKSSSETNPESQ-NSKTVSKNCSQKDKKDSKNSKKTN--TEFLHTK 217
L+++ E + S + + E + S +V N S KD + SK T T+ L+ K
Sbjct: 493 N-LETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVK 551
Query: 218 NNPKKDLKRSKTSNDPISEI-CSENSLNVDFLMLVG-------------QSDDESINFDA 263
P SN PI C E + D G SD+E + +
Sbjct: 552 LTPVS------LSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENE 605
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
+++ + T ++ T+ N S+ E+ + K+ +K+ V+K DK+
Sbjct: 606 VSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNS--DEECNETVKEKQKLSVPVRKKDKR 663
Query: 324 K--DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381
D D + + E D D ++ K+ + S+DT+ +
Sbjct: 664 NSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNH 723
Query: 382 NDSRNLKKASKNDDKKKDAKKITFS-----------------------TDSESELESKES 418
+LK + DDK K +K + S T SES E
Sbjct: 724 KTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSEL 783
Query: 419 QKDEKKDKK--DSKTDNKK--SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK 474
+K+ K K ++T K+ + K+ + S D KG +G K+ K ++ S D ++
Sbjct: 784 EKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAER 843
Query: 475 KDAKKNAESTEMESD-----LELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529
K ++ S E D +EL+ ++ S + K + K+ T E + ++
Sbjct: 844 KQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE 903
Query: 530 TGFKTSTKIKGSDTESEESLYKPGAKK--KIDESDGTSANSKMEGLESKRGFRMSSKKTT 587
T K S +K + + A+K K D+SD TS + K +SK+G K +
Sbjct: 904 TKEK-SKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK---QSKKGTEEKKKPSD 959
Query: 588 FNEKGEKASTGRVPPSREKPPLPACEPSLPSPK 620
F +K K S LP E PK
Sbjct: 960 FKKKVIKMEQQYESSSDGTEKLPEREEICHFPK 992
Score = 72.0 bits (175), Expect = 2e-12
Identities = 113/542 (20%), Positives = 211/542 (38%), Gaps = 72/542 (13%)
Query: 132 KKKGGSYATNPESKQIVEEKTKRQNEADK---TPLKSSH-ENEQSKKSKSSSETNPESQN 187
KK+ S +T+ K +E++ E K T KS H + + KK + E
Sbjct: 872 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 931
Query: 188 SKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
K S S+ DKK SK + + K K ++ ++S+D ++ + F
Sbjct: 932 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI-CHF 990
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
+ Q + + + + + SK + + Y +K T K S SED K
Sbjct: 991 PKGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSCDS---SEDKKSKN 1046
Query: 308 KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE---------RKDTKKDKKKLKKDD 358
+ KK K K ++D S+D E K++ ++ ++++ L
Sbjct: 1047 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1106
Query: 359 KKKDTKKYPESTDTE--SGDAKDARNDSRNLKKASKNDDKKKDAKK---------ITFST 407
K+ + S+D E S D K + + + KKA +KK+++ + IT S+
Sbjct: 1107 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSS 1166
Query: 408 DSESELESKESQKDEKKDKKDSK--TDN------------------KKSVKNDEESTDAD 447
S+ E + + S + D++ K T+N KSV + D D
Sbjct: 1167 SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDD 1226
Query: 448 SEPKGDSKKG----------KKDEKKGKKDSKKDDKKKDAKKNAEST-EMESDLELKKDK 496
++P+ K DE D ++ KK+ K+N E+ + E+ ++ +
Sbjct: 1227 NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1286
Query: 497 KHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG------SDTESEES-L 549
E+ + + R +D E E KT K ++KG S +SE+S
Sbjct: 1287 DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDF 1346
Query: 550 YKPGAKKKIDESDG-----TSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSR 604
+ G +++ ES+ T + K E E++R ++ K+ + + +S +
Sbjct: 1347 QESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEE 1406
Query: 605 EK 606
E+
Sbjct: 1407 EE 1408
Score = 65.5 bits (158), Expect = 1e-10
Identities = 105/549 (19%), Positives = 223/549 (40%), Gaps = 127/549 (23%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTK--------RQNEADKTP 162
KK K ++++K + KK K Y ++ + + + E+ + +Q + T
Sbjct: 944 KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTD 1003
Query: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNS----KKTNTEFLHTKN 218
+ + + K SK E + ++ S +C + K SKN +K + L +
Sbjct: 1004 GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063
Query: 219 NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSL 278
++D S T + E D + D L+ +N S
Sbjct: 1064 RKRQDCSSSDTEKYSMKE-------------------DGCNSSDKRLKRIELRERRNLS- 1103
Query: 279 KYTKYTKKDTKK--NAKKSSDAE--SEDSKDAKKDSKKVKKNVKKDDKKKDV------KK 328
+K++TK+ + SSDAE SED+K K+ + KK V +KK++ +K
Sbjct: 1104 -----SKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1158
Query: 329 DTESTDAESGDSKDERKDT----KKDKKKLK----------------KDDKKKDTKKYPE 368
+ T + S D +D+ +++ D++K+K + +K P
Sbjct: 1159 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1218
Query: 369 STDTESGDAKDARNDSRNL-----------KKASKNDDKKKDAKKITFS----------- 406
+ D + D ++ + + +DD+ ++ KK T
Sbjct: 1219 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1278
Query: 407 ---TDSESELESKESQKDEKKDK--------KDSKT-DNKKSVKND-------------- 440
+SES+ +S+ES+K + + D ++ + KK+ +
Sbjct: 1279 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1338
Query: 441 EESTDADSEPKGDSKK--GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKD--- 495
E+S D+D + G S++ +DE++ + S K + ++ +++ + + +++++D
Sbjct: 1339 EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS 1398
Query: 496 --KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK--TGFKTSTKIKGSD---TESEES 548
K +S+E++ K++ +++ ++ E + E D+S G K KI D TE++ +
Sbjct: 1399 ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1458
Query: 549 LYKPGAKKK 557
L + ++K
Sbjct: 1459 LKEEEERRK 1467
Score = 39.7 bits (91), Expect = 0.009
Identities = 66/248 (26%), Positives = 98/248 (39%), Gaps = 40/248 (16%)
Query: 348 KKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKN---DDKKKDAKKIT 404
+++KKK+K D +K + K E T S KK S N ++KK D
Sbjct: 254 QQNKKKIKVDSEKSN--KVYEHTSRFSP------------KKTSSNCNGEEKKLDDSCSG 299
Query: 405 FSTDSESEL-ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
T S S L KE K KK + + N VK +++TD + K K
Sbjct: 300 SVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKS 359
Query: 464 GKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH--------SKEKKG------SKKDI 509
D KK + N+E M++ + K K+H +K +KG KKDI
Sbjct: 360 VLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI 419
Query: 510 -KKDARKDTESTDAEF------DESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESD 562
K +A+ + D+E E +T T + K SD EE Y+P + + D
Sbjct: 420 SKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSD-RKEEPQYEPANTSEDLDMD 478
Query: 563 GTSANSKM 570
S S +
Sbjct: 479 IVSVPSSV 486
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 88.6 bits (218), Expect = 2e-17
Identities = 125/596 (20%), Positives = 247/596 (41%), Gaps = 114/596 (19%)
Query: 39 KPLQRGTNDKSRP--LKSQITVTRHDKRKLEEGQK--PAHKWIRHSFRKILQWPPIYTAA 94
K ++GT +K +P K ++ +G + P + I H + I Q T
Sbjct: 983 KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1042
Query: 95 REQTPFRHLYTSKTHLKKAEYKKSKDEKGGT-PLKKDSKKKGGSYATNPESKQIVEEKTK 153
+++ TSK + ++Y + KG + +D K K G+Y + +++ + ++
Sbjct: 1043 EKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR 1102
Query: 154 RQ------------------NEADKT----------PLKSSHENEQSKKSKSSSETNPES 185
++ N +DK L S ++ + SSS+ S
Sbjct: 1103 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1162
Query: 186 QNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSN------DPISEICS 239
+++K + S K K KK N+ TK + D+ S +S+ + I E S
Sbjct: 1163 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK-QADITSSSSSDIEDDDQNSIGEGSS 1221
Query: 240 ---------ENSLNVDFLMLVGQSDDESINFDAWLR---NYSQNNSKNYSLKYTKYTKKD 287
EN + S DE+++ + + N+ +N K K ++
Sbjct: 1222 DEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK--KMLLEE 1279
Query: 288 TKKNAKKSSDAESEDSKDA--KKDSKKVKKNVKKDDKKKDVKKDTESTDAES-------- 337
K N D S+D + K+ K+ ++N ++ K V +++S ES
Sbjct: 1280 IKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHR 1339
Query: 338 ----------GDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTD-TESGDAKDA------ 380
G+S +E+K K+ K++K +++K + + E +D ESG +++
Sbjct: 1340 LLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDE 1399
Query: 381 -RNDSRNLKKASKNDD-----KKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
R +R+ KKA ++ +KK ++I DS SE +S +++E+K++++
Sbjct: 1400 QRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEE------ 1453
Query: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKK 494
+ +EE + + + DSK K KK +K KDDK + +NA E E
Sbjct: 1454 ---EEEEEEEEEEEDENDDSKSPGKGRKKIRK-ILKDDKLRTETQNALKEEEE------- 1502
Query: 495 DKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTK-IKGSDTESEESL 549
+ K+ ++++ +++ ++ E +++S T +TK + D E++E L
Sbjct: 1503 -----RRKRIAEREREREKLREV----IEIEDASPTKCPITTKLVLDEDEETKEPL 1549
Score = 85.9 bits (211), Expect = 1e-16
Identities = 114/497 (22%), Positives = 206/497 (41%), Gaps = 59/497 (11%)
Query: 93 AAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNP--ESKQIVEE 150
++ T ++T+ L + + KD+KG K+ S G + T +K +
Sbjct: 747 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR--KRKSSTSGSDFDTKKGKSAKSSIIS 804
Query: 151 KTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTN 210
K KRQ +++ S++++E K+ KS S+ K + +D K+SKK
Sbjct: 805 KKKRQTQSES----SNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM 860
Query: 211 TEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQ 270
H K KTS + S+ F G D ++ + LR+
Sbjct: 861 DNQGH---------KNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME--LRD--- 906
Query: 271 NNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDS-KDAKKDSKKVKKNVKKDDKKKDVKKD 329
+ K+ A S+D + S K+ S +V+K + +K K +K
Sbjct: 907 --------------RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 952
Query: 330 TESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKK 389
T + G S K KKD+ +D KK +KK E S K + +
Sbjct: 953 T-CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYES 1011
Query: 390 ASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKND--EEST-DA 446
+S +K + ++I ++++ + ++K K KT KK +D E+ST
Sbjct: 1012 SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG 1071
Query: 447 DSEPKGDSKKGK-----KDEKKGKKDSKKDDKKKD-AKKNAESTEME------SDLELKK 494
DS + KK K +++K+ K K K++D + + E M+ SD LK+
Sbjct: 1072 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR 1131
Query: 495 DKKHSKEKKGSKKDIKKDARKDTESTDAE--FDESSKTGFKTSTKIKGSDT-ESEESLYK 551
+ + SK++ K+ + + S+DAE +++ K +TS+K K E + + +
Sbjct: 1132 IELRERRNLSSKRN-TKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1190
Query: 552 PGAKKKIDESDGTSANS 568
K+K ++D TS++S
Sbjct: 1191 TSTKRK--QADITSSSS 1205
Score = 84.0 bits (206), Expect = 4e-16
Identities = 108/495 (21%), Positives = 198/495 (40%), Gaps = 59/495 (11%)
Query: 148 VEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK 207
+ EK +++++D+T S + +QSKK + + P K + + D
Sbjct: 964 IAEKFLKKDQSDET---SEDDKKQSKKG-TEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 208 KTNTEFLH-------TKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESIN 260
E H KN K+SK D S+ E S + G S D S +
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 261 FDAWLRNYSQNNSK-----NYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
+ Y + + S K + DT+K + K S D K K+ + ++
Sbjct: 1080 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRLKRIELRERR 1138
Query: 316 NVKKDDKKKDVKKDTESTDAE--SGDSKDERKDTKKDKKKLKKDDKKKDT------KKYP 367
N+ K+++ + S+DAE S D+K +++ T KK + +KK+++ +K
Sbjct: 1139 NLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1198
Query: 368 ESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK-------ITFSTDSESELESKESQK 420
+ T + S D +D +D ++ + S ++ K K + F S E SK
Sbjct: 1199 DITSSSSSDIED--DDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1256
Query: 421 DEKKDKKDSKTDNK--KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK 478
D D+ +N+ K + +E + S+ G S ++ KK +++ +
Sbjct: 1257 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1316
Query: 479 KNAESTEMESDLELKKDKKH---------------SKEKKGSK----KDIKKDARKDTES 519
KN ++E +SD E K ++ S E+K +K K++K R+ S
Sbjct: 1317 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1376
Query: 520 TDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGF 579
D+E + ++G S++E E+ AKK E + S K + K
Sbjct: 1377 EDSEDSDFQESGVSEEV----SESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1432
Query: 580 RMSSKKTTFNEKGEK 594
SS+ + +E+ E+
Sbjct: 1433 DSSSENKSNSEEEEE 1447
Score = 72.0 bits (175), Expect = 2e-12
Identities = 135/633 (21%), Positives = 234/633 (36%), Gaps = 85/633 (13%)
Query: 47 DKSRPLKSQITVTRHDKRKLEEGQKPA---HKWIRHSFRKILQWPPIYTAAREQTPFRHL 103
+K + K + + K +G+KP K I S K+ +R+Q H+
Sbjct: 424 NKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKL---------SRKQVDSEHM 474
Query: 104 YTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESK---QIVEEKTKRQNEADK 160
+ + E +++ GG K D K++ N IV + + +
Sbjct: 475 HQNVP----TEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFE 530
Query: 161 TPLKSSHENEQSKKSKSSSETNPESQ-NSKTVSKNCSQKDKKDSKNSKKTN--TEFLHTK 217
L+++ E + S + + E + S +V N S KD + SK T T+ L+ K
Sbjct: 531 N-LETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVK 589
Query: 218 NNPKKDLKRSKTSNDPISEI-CSENSLNVDFLMLVG-------------QSDDESINFDA 263
P SN PI C E + D G SD+E + +
Sbjct: 590 LTPVS------LSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENE 643
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
+++ + T ++ T+ N S+ E+ + K+ +K+ V+K DK+
Sbjct: 644 VSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNS--DEECNETVKEKQKLSVPVRKKDKR 701
Query: 324 K--DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381
D D + + E D D ++ K+ + S+DT+ +
Sbjct: 702 NSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNH 761
Query: 382 NDSRNLKKASKNDDKKKDAKKITFS-----------------------TDSESELESKES 418
+LK + DDK K +K + S T SES E
Sbjct: 762 KTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSEL 821
Query: 419 QKDEKKDKK--DSKTDNKK--SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK 474
+K+ K K ++T K+ + K+ + S D KG +G K+ K ++ S D ++
Sbjct: 822 EKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAER 881
Query: 475 KDAKKNAESTEMESD-----LELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529
K ++ S E D +EL+ ++ S + K + K+ T E + ++
Sbjct: 882 KQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE 941
Query: 530 TGFKTSTKIKGSDTESEESLYKPGAKK--KIDESDGTSANSKMEGLESKRGFRMSSKKTT 587
T K S +K + + A+K K D+SD TS + K +SK+G K +
Sbjct: 942 TKEK-SKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK---QSKKGTEEKKKPSD 997
Query: 588 FNEKGEKASTGRVPPSREKPPLPACEPSLPSPK 620
F +K K S LP E PK
Sbjct: 998 FKKKVIKMEQQYESSSDGTEKLPEREEICHFPK 1030
Score = 72.0 bits (175), Expect = 2e-12
Identities = 113/542 (20%), Positives = 211/542 (38%), Gaps = 72/542 (13%)
Query: 132 KKKGGSYATNPESKQIVEEKTKRQNEADK---TPLKSSH-ENEQSKKSKSSSETNPESQN 187
KK+ S +T+ K +E++ E K T KS H + + KK + E
Sbjct: 910 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 969
Query: 188 SKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDF 247
K S S+ DKK SK + + K K ++ ++S+D ++ + F
Sbjct: 970 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI-CHF 1028
Query: 248 LMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
+ Q + + + + + SK + + Y +K T K S SED K
Sbjct: 1029 PKGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSCDS---SEDKKSKN 1084
Query: 308 KDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE---------RKDTKKDKKKLKKDD 358
+ KK K K ++D S+D E K++ ++ ++++ L
Sbjct: 1085 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1144
Query: 359 KKKDTKKYPESTDTE--SGDAKDARNDSRNLKKASKNDDKKKDAKK---------ITFST 407
K+ + S+D E S D K + + + KKA +KK+++ + IT S+
Sbjct: 1145 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSS 1204
Query: 408 DSESELESKESQKDEKKDKKDSK--TDN------------------KKSVKNDEESTDAD 447
S+ E + + S + D++ K T+N KSV + D D
Sbjct: 1205 SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDD 1264
Query: 448 SEPKGDSKKG----------KKDEKKGKKDSKKDDKKKDAKKNAEST-EMESDLELKKDK 496
++P+ K DE D ++ KK+ K+N E+ + E+ ++ +
Sbjct: 1265 NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1324
Query: 497 KHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKG------SDTESEES-L 549
E+ + + R +D E E KT K ++KG S +SE+S
Sbjct: 1325 DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDF 1384
Query: 550 YKPGAKKKIDESDG-----TSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSR 604
+ G +++ ES+ T + K E E++R ++ K+ + + +S +
Sbjct: 1385 QESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEE 1444
Query: 605 EK 606
E+
Sbjct: 1445 EE 1446
Score = 65.5 bits (158), Expect = 1e-10
Identities = 105/549 (19%), Positives = 223/549 (40%), Gaps = 127/549 (23%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTK--------RQNEADKTP 162
KK K ++++K + KK K Y ++ + + + E+ + +Q + T
Sbjct: 982 KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTD 1041
Query: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNS----KKTNTEFLHTKN 218
+ + + K SK E + ++ S +C + K SKN +K + L +
Sbjct: 1042 GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1101
Query: 219 NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSL 278
++D S T + E D + D L+ +N S
Sbjct: 1102 RKRQDCSSSDTEKYSMKE-------------------DGCNSSDKRLKRIELRERRNLS- 1141
Query: 279 KYTKYTKKDTKK--NAKKSSDAE--SEDSKDAKKDSKKVKKNVKKDDKKKDV------KK 328
+K++TK+ + SSDAE SED+K K+ + KK V +KK++ +K
Sbjct: 1142 -----SKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1196
Query: 329 DTESTDAESGDSKDERKDT----KKDKKKLK----------------KDDKKKDTKKYPE 368
+ T + S D +D+ +++ D++K+K + +K P
Sbjct: 1197 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1256
Query: 369 STDTESGDAKDARNDSRNL-----------KKASKNDDKKKDAKKITFS----------- 406
+ D + D ++ + + +DD+ ++ KK T
Sbjct: 1257 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1316
Query: 407 ---TDSESELESKESQKDEKKDK--------KDSKT-DNKKSVKND-------------- 440
+SES+ +S+ES+K + + D ++ + KK+ +
Sbjct: 1317 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1376
Query: 441 EESTDADSEPKGDSKK--GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKD--- 495
E+S D+D + G S++ +DE++ + S K + ++ +++ + + +++++D
Sbjct: 1377 EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS 1436
Query: 496 --KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK--TGFKTSTKIKGSD---TESEES 548
K +S+E++ K++ +++ ++ E + E D+S G K KI D TE++ +
Sbjct: 1437 ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1496
Query: 549 LYKPGAKKK 557
L + ++K
Sbjct: 1497 LKEEEERRK 1505
Score = 39.7 bits (91), Expect = 0.009
Identities = 66/248 (26%), Positives = 98/248 (39%), Gaps = 40/248 (16%)
Query: 348 KKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKN---DDKKKDAKKIT 404
+++KKK+K D +K + K E T S KK S N ++KK D
Sbjct: 292 QQNKKKIKVDSEKSN--KVYEHTSRFSP------------KKTSSNCNGEEKKLDDSCSG 337
Query: 405 FSTDSESEL-ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
T S S L KE K KK + + N VK +++TD + K K
Sbjct: 338 SVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKS 397
Query: 464 GKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH--------SKEKKG------SKKDI 509
D KK + N+E M++ + K K+H +K +KG KKDI
Sbjct: 398 VLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI 457
Query: 510 -KKDARKDTESTDAEF------DESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESD 562
K +A+ + D+E E +T T + K SD EE Y+P + + D
Sbjct: 458 SKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSD-RKEEPQYEPANTSEDLDMD 516
Query: 563 GTSANSKM 570
S S +
Sbjct: 517 IVSVPSSV 524
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/155 (22%), Positives = 64/155 (41%), Gaps = 21/155 (13%)
Query: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAES---GDSKDERKDT 347
++++S + S +++ K+ + D ++ K++ S+ +S G S+ +RK +
Sbjct: 25 SSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPS 84
Query: 348 KKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFST 407
KY ES D + D + D+ N + S+ND + K T
Sbjct: 85 --------------IVTKYVESDDEKPLDDETVNEDASN--ENSENDITMQSLPKGTVIV 128
Query: 408 DSESEL-ESKESQK-DEKKDKKDSKTDNKKSVKND 440
E L E K+ K E + + KT+N K D
Sbjct: 129 QPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGED 163
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 88.6 bits (218), Expect = 2e-17
Identities = 111/514 (21%), Positives = 206/514 (40%), Gaps = 72/514 (14%)
Query: 121 EKGGTPLKKDSKKKGGSYATNPESKQIVE-EKTKRQNEADKTPLKSSHENEQSKKSKSSS 179
E+ G KDS++ G + N SK+++ E+ KR +E +++ + K+ S
Sbjct: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHEL----IEAEGIEDIEKEDIESQ 171
Query: 180 ETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICS 239
E + T + +D ++ +N K + + +++ + S ++E
Sbjct: 172 EIEAQEGEDDTF---LTAQDGEEEENEKD-----IAGSGDGTQEVSKPLPSEGSLAEADH 223
Query: 240 ENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAE 299
++ V +++D++I+ + + L T K T A K D +
Sbjct: 224 TAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQ 283
Query: 300 SEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
++ +K+SK + N D KK+ D GD + K+ ++ KK + DK
Sbjct: 284 DAIAQSPEKESKDYEMNANHKDGKKE--------DCVKGDPVE--KEARESSKKAESGDK 333
Query: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ 419
+KDT K S+ SG AK + +S++ K +SK+D + + + +++ S S
Sbjct: 334 EKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSS 393
Query: 420 KDEKKDKKD-----SKTDNKKSVKNDEE-------------STDAD-------------- 447
+ D K+ K + K V N ST+
Sbjct: 394 NTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQ 453
Query: 448 ----SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK 503
+ KGD K E K + D K + KKN ++ +KK+ EK+
Sbjct: 454 LISVEKVKGDPSK---KEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKE-----EKR 505
Query: 504 GSKKDIKKDARKDTESTDAEFDESSKTGF--KTSTKIKGSDTESEESLYKPGAKKKIDES 561
S+K KK++ KDT+ + + DE + G +TS IK S+ + S PG +D++
Sbjct: 506 SSEKSEKKES-KDTKKIEGK-DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQT 563
Query: 562 DGTSANSKMEG-LESKRGFRMSSKKTTFNEKGEK 594
G G E G ++ + ++K +K
Sbjct: 564 KGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 597
Score = 67.8 bits (164), Expect = 3e-11
Identities = 106/479 (22%), Positives = 183/479 (38%), Gaps = 99/479 (20%)
Query: 44 GTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHS----FRKILQWPPIYTAAREQTP 99
GT + S+PL S+ ++ D EE + AH ++ + +Q T +
Sbjct: 204 GTQEVSKPLPSEGSLAEADHTAHEEME--AHTTVKEAEDDNISVTIQAEDAITLDFDGDD 261
Query: 100 FRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEAD 159
L T K ++K + + SK + G + + +K+ Y N K +E + + +
Sbjct: 262 L--LETGK-NVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE 318
Query: 160 KTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNN 219
K +SS + E K K + + P S + +K+ S K+ KDSK S K
Sbjct: 319 KEARESSKKAESGDKEKDTLKKGPSSTGASGQAKS-SSKESKDSKTSSK----------- 366
Query: 220 PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLK 279
D K S +S S ++N W+ S N
Sbjct: 367 ---DDKGSTSSTSGSSGSSTKN---------------------IWVSGLSSNT------- 395
Query: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK----KDVKKDTESTDA 335
K++D ++ K K S KV N + K + TE +
Sbjct: 396 --------------KAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRC 441
Query: 336 ESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDD 395
+ + E +K+K D KK+ KK ND ++ ++S D
Sbjct: 442 IAHLHRTELHGQLISVEKVKGDPSKKEMKK---------------ENDEKSSSRSS--GD 484
Query: 396 KKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSE--PKGD 453
KK + + + + S + E + S+K EKK+ KD+K K KND ++ SE K +
Sbjct: 485 KKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSE 544
Query: 454 SKKGKKDEKKGKK---DSKKDDKKKDAKK------NAESTEME-SDLELKKDKKHSKEK 502
KK + G D K D + +++ + S E E + L+ K+DK + +++
Sbjct: 545 EKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKE 603
Score = 40.0 bits (92), Expect = 0.007
Identities = 46/218 (21%), Positives = 100/218 (45%), Gaps = 22/218 (10%)
Query: 346 DTKKDKKKLKKDDKKKDT---KKYPESTDTESGDAKDAR----NDSRNLKKASKNDDKKK 398
D K + K+ D T + ++ + E GD + D+ N KK +K KK
Sbjct: 29 DLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPN-KKPTKGKGKKH 87
Query: 399 DAKKITFSTDSESELESK----ESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDS 454
+A +++ E + K E+Q+ ++D D D+++ +N+EE+ + +
Sbjct: 88 EADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEE 147
Query: 455 KKGKKD--EKKGKKDSKKDDKKKDAKKNAESTEMESDLELK----KDKKHSKEKKGSKKD 508
K + E +G +D +K+D + + E+ E E D L +++++ K+ GS
Sbjct: 148 NKRAHELIEAEGIEDIEKEDIE---SQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDG 204
Query: 509 IKKDARK-DTESTDAEFDESSKTGFKTSTKIKGSDTES 545
++ ++ +E + AE D ++ + T +K ++ ++
Sbjct: 205 TQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDN 242
Score = 38.1 bits (87), Expect = 0.026
Identities = 41/145 (28%), Positives = 60/145 (41%), Gaps = 23/145 (15%)
Query: 443 STDADSEP--KGDSKKGKKDEKKGKKDSKKDDKKKDAK-KNAESTEMESDLELK------ 493
STD ++ KG KK + DE G + D KD + +N E+ E + + ELK
Sbjct: 71 STDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFG 130
Query: 494 ---KDKKHSK------EKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
++ HSK E K + + I+ + +D E D E E + T + D E
Sbjct: 131 ENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGE 190
Query: 545 SEESLYKPGAKKKIDESDGTSANSK 569
EE+ K DGT SK
Sbjct: 191 EEEN-----EKDIAGSGDGTQEVSK 210
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 87.0 bits (214), Expect = 5e-17
Identities = 131/572 (22%), Positives = 222/572 (38%), Gaps = 71/572 (12%)
Query: 16 NSIPISESSRKSWNQKHFALTFPKPL-QRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAH 74
+S+ + ESS KS K A + L +R +K L + + D R +EE K
Sbjct: 537 SSVDLEESSTKSLEPK--AARIKEVLKERKVLEKKVALSKK---RKKDSRNVEENSKKKQ 591
Query: 75 KWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEK---GGTPLKKDS 131
++ E+ L TS+ H +K + SK+ K + K +
Sbjct: 592 QY-------------------EEDSKETLKTSE-HCEKEKISSSKELKHVHAKSEPSKPA 631
Query: 132 KKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTV 191
++ S E+K E K +R+++ +T E Q + + E T
Sbjct: 632 RRLSESLHVVDENKN--ESKLEREHKR-RTSTPVIMEGVQEETDTRDVKRQVERSEICTE 688
Query: 192 SKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNV------ 245
+ K+ K+ KK ++E H K+ KK++K SK + + SE+ L+V
Sbjct: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPER-EKTPSEDKLSVKHKYKG 747
Query: 246 DFLMLVGQSDD-ESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSK 304
D + G + S + Q S+ L T++ +K ++ +D K
Sbjct: 748 DCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGK 807
Query: 305 DAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTK 364
+ K +NV+K++ KK+ + E T AE + D+K K L +
Sbjct: 808 PVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRS--SDSKIQKDSLGSKQHGITLQ 865
Query: 365 KYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK 424
+ ES + D D+ N NLK +K+ K + E +L K K + K
Sbjct: 866 RRSESYSEDKCD-MDSTNMDSNLKPEEVVHKEKRRTKSLL-----EEKLVLKSKSKTQGK 919
Query: 425 DKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484
K +T+ + E +T + PK D +K ++ DS+K K K K E T
Sbjct: 920 QVKVVETELQ------EGATKQATTPKPDKEKNTEE-----NDSEKQRKSKVEDKPFEET 968
Query: 485 EMESDLELKKDKKHSKEKKGSKKD----IKKDARKDTESTDAEFDESSKTGFKT-STKIK 539
+E LE HS +K S + K+ + D +ST + G K+ S K
Sbjct: 969 GVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHS 1028
Query: 540 GSDTESEESLYKPGAKKKIDESDGTSANSKME 571
D + ++ + K D+ DG +S E
Sbjct: 1029 SKDIKKKD-------ENKSDDKDGKEVDSSHE 1053
Score = 82.8 bits (203), Expect = 9e-16
Identities = 101/498 (20%), Positives = 201/498 (40%), Gaps = 81/498 (16%)
Query: 144 SKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSE-TNPESQNSKTVSKNCSQKDKKD 202
+K + +E ++++N++ K NE+ ++ K E T + +SK KD+K
Sbjct: 304 NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQ 363
Query: 203 SKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFD 262
+K + + + KN+ K K + + + S I S+ VD L + S + +
Sbjct: 364 AKEKEVESLKLPSEKNSNK--AKTVEGTKEDFSLIDSD----VDGLTDITVSSVHTSDLS 417
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKK---VKK---- 315
++ + + + S++ + T D +KN + + ++ DS + K S + V K
Sbjct: 418 SFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLY 477
Query: 316 ---------NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKY 366
+ + +++ + K+ E ++++ ++ +K K + K K K +
Sbjct: 478 SKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRS 537
Query: 367 P---ESTDTESGDAKDAR----------------------NDSRNLKKASKNDDKKKDAK 401
E + T+S + K AR DSRN+++ SK + ++
Sbjct: 538 SVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDS 597
Query: 402 KITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDE 461
K T T E E S K+ K +K++ K + ES E K +SK ++ +
Sbjct: 598 KETLKTSEHCEKEKISSSKELK--HVHAKSEPSKPARRLSESLHVVDENKNESKLEREHK 655
Query: 462 KKGK-----KDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD-------- 508
++ + +++ +D K+ E +E+ ++ E +K K K +K KKD
Sbjct: 656 RRTSTPVIMEGVQEETDTRDVKRQVERSEICTE-EPQKQKSTLKNEKHLKKDDSETPHLK 714
Query: 509 --IKKDARKDTESTDAEFDESS---------------KTGFKTSTKIKGSDTESEESLYK 551
+KK+ + E + E S KTG +T + EE++ K
Sbjct: 715 SLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQK 774
Query: 552 PGAKKKIDESDGTSANSK 569
+ K+ D T SK
Sbjct: 775 QSQQTKLSSDDKTERKSK 792
Score = 79.3 bits (194), Expect = 1e-14
Identities = 111/539 (20%), Positives = 223/539 (41%), Gaps = 67/539 (12%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENE 170
+K E KK K EK T K D KK + +++++ +EK ++ E + L S +
Sbjct: 330 EKGERKKEKKEK--TEKKFDHSKK------SEDTQKVKDEKQAKEKEVESLKLPSEKNSN 381
Query: 171 QSKKSKSSSE------------TNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKN 218
++K + + E T+ + T + ++D ++ + + E T +
Sbjct: 382 KAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSD 441
Query: 219 NPKKDLK-RSKTSNDPISEICSEN----SLNVDFLMLVGQSD-DESINFDAWLRNYSQNN 272
+ +K+ + ++KT SE +++ ++ +L SD D+ + + ++ ++
Sbjct: 442 DEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK 501
Query: 273 SKNYSLKYTKYTKKDTKKNAK----KSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKK 328
+ + K + K+ K KSS + + + K K + K+V K
Sbjct: 502 EERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLK 561
Query: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
+ + + + SK +KD++ ++ KK + ++ K E+ T K+ + S+ LK
Sbjct: 562 ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK--ETLKTSEHCEKEKISSSKELK 619
Query: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA-- 446
+ K A++++ S E+K K E++ K+ +T ++ +E TD
Sbjct: 620 HVHAKSEPSKPARRLSESLHVVD--ENKNESKLEREHKR--RTSTPVIMEGVQEETDTRD 675
Query: 447 ------DSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLEL-KKDKKHS 499
SE + + +K K +K KKDD + K+ E++S E +++K S
Sbjct: 676 VKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPS 735
Query: 500 KEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKT---------STKIKGSDTESEESLY 550
++K K K D T D SS+ G K TK+ D +S +
Sbjct: 736 EDKLSVKHKYKGDCMHKT--GDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKH 793
Query: 551 KPGAKKKIDESDG---------TSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV 600
+ K + DG T N + E + +R R+S++KT K ++S ++
Sbjct: 794 RNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKER--RLSAEKTKAEHKSRRSSDSKI 850
Score = 73.2 bits (178), Expect = 7e-13
Identities = 112/558 (20%), Positives = 215/558 (38%), Gaps = 66/558 (11%)
Query: 39 KPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQT 98
+ ++R P K + T+ K ++ + P K + K + P RE+T
Sbjct: 678 RQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKP----EREKT 733
Query: 99 PFRHLYTSKTHLK-KAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNE 157
P S+ L K +YK K G + S +KG N + + ++TK ++
Sbjct: 734 P------SEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQS---QQTKLSSD 784
Query: 158 ADKTPLKSSHENEQS-----KKSKSSSE------TNPESQNSKTVSKNCSQKDKKDSKNS 206
DKT KS H NE+ K K SE N +N+K + ++K K + K+
Sbjct: 785 -DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSR 843
Query: 207 KKTNTEFLHTKNNPKKD-LKRSKTSNDPISEICSENSLNVDFLMLVGQSDDES------- 258
+ ++++ K+ + + S + C +S N+D + + +
Sbjct: 844 RSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSL 903
Query: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVK 318
+ L++ S+ K + T+ + TK+ D E ++ DS+K +K+
Sbjct: 904 LEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEEN---DSEKQRKSKV 960
Query: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAK 378
+D ++ + A S ++ + + K L K+ K D + + D
Sbjct: 961 EDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGH 1020
Query: 379 DARN---DSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKK 435
+R+ S+++KK +N KD K++ S + S +K ++ ++ + +
Sbjct: 1021 KSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ 1080
Query: 436 SVKNDEESTDAD--SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELK 493
+ EE A+ S P G S + K +++ + D++ E+ +
Sbjct: 1081 EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENV-------FE 1133
Query: 494 KDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPG 553
K S++DI + K S + DE +T T +D+++ YKPG
Sbjct: 1134 VSKTQDNRNNNSQQDIDSENMKQKTSATVQKDE-----LRTCT----ADSKATAPAYKPG 1184
Query: 554 AKKKIDESDGTSANSKME 571
GT NS E
Sbjct: 1185 R--------GTGVNSNSE 1194
Score = 68.9 bits (167), Expect = 1e-11
Identities = 105/506 (20%), Positives = 198/506 (39%), Gaps = 87/506 (17%)
Query: 169 NEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSK 228
N+++ +++S+ET+ ++ S+ SK + D+ K+ +E + K D
Sbjct: 212 NQEASAARASTETS-NAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEG 270
Query: 229 TSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDT 288
P SE S+ V+ + +NY++ + N + K ++++
Sbjct: 271 LETAPKSEEFSDLPCPVEEI-----------------KNYTKEH--NNLILLNKDVQQES 311
Query: 289 KKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDS-KDERKDT 347
+ KS+D K KK K KK+ K+K KK S +E KDE++
Sbjct: 312 SEQKNKSTD------KGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAK 365
Query: 348 KKDKKKLKKDDKKKDTK-KYPEST-------DTESGDAKDARNDSRNLKKASKNDDKKKD 399
+K+ + LK +K K K E T D++ D S + S ++ ++
Sbjct: 366 EKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEE 425
Query: 400 AKKITFSTDSESELESKESQKDEKKDKK----DSKTDNKKSVKN---------DEESTDA 446
+ +T + E E+ S + +K+++ K DS KSV++ + +D+
Sbjct: 426 -EVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDS 484
Query: 447 DSEPKGDSKK-----------------GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESD 489
D E + ++ +K E+K K+ ++K K + S ++E
Sbjct: 485 DDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEES 544
Query: 490 ------------LELKKDKKHSKEKKGSKKDIKKDARKDTEST--DAEFDESSKTGFKTS 535
E+ K++K ++K K KKD+R E++ +++E SK KTS
Sbjct: 545 STKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTS 604
Query: 536 TKIKGSDTESEESLYKPGAK-------KKIDESDGTSANSKMEGLESKRGFRMSSKKTTF 588
+ S + L AK +++ ES +K E + R +S
Sbjct: 605 EHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIM 664
Query: 589 NEKGEKASTGRVPPSREKPPLPACEP 614
E+ T V E+ + EP
Sbjct: 665 EGVQEETDTRDVKRQVERSEICTEEP 690
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/381 (18%), Positives = 150/381 (39%), Gaps = 34/381 (8%)
Query: 107 KTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQ---IVEEKTKRQNEADKTPL 163
K +LK Y S++EK G L GG + E ++ +V E +N +T
Sbjct: 2667 KANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNE 2726
Query: 164 KSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK-KTNTEFLHTKNNPKK 222
+ E+ + S + N E+ + +V + + ++++ K K +L +++ P
Sbjct: 2727 EIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDD 2786
Query: 223 DLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTK 282
+ + + C E + ++ S + + + S+ NS + K
Sbjct: 2787 NPDVLDSRIETAQRQCPETEPH-------DTKEENSRDLEELPKTSSETNSTTSRVMEEK 2839
Query: 283 YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK-----KDTESTDAES 337
++ +K + + K ++D + K + +K V+ KD TD +
Sbjct: 2840 DEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTD--T 2897
Query: 338 GDSKDERKDTKKDKKKLKKDDKKKDTKKYPE-STDTESGDAKDARNDSRNLKKASKNDDK 396
G E+ + K ++ D+ K+T E S + G+ K + R +K ++
Sbjct: 2898 GIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRS--- 2954
Query: 397 KKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKK 456
+T S D+ES E ++ +K D D K+ ++EE + + EP G + +
Sbjct: 2955 ------LTVSDDAESS----EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTR 3004
Query: 457 G--KKDEKKGKKDSKKDDKKK 475
+ + ++ K K+K
Sbjct: 3005 STTRSEAQRSKTQLSPSIKRK 3025
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 25/214 (11%)
Query: 357 DDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESK 416
DD+K DT + T G + + ND+ ++ + + +++ A + + T S ++ +
Sbjct: 175 DDEKPDTSLITQGVPT-PGPSANVANDAMSILETITSLNQEASAARASTET-SNAKTSER 232
Query: 417 ESQKDEKKDKKDSKTDNKKSVKN--DEESTDADSEPKGDSKKGKKDE--------KKGKK 466
S+K + D+ TD +++ ++ D+E + ADS +G K +E ++ K
Sbjct: 233 ASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKN 292
Query: 467 DSKKDDK----KKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA 522
+K+ + KD ++ ES+E ++ K +KK +KG +K KK E T+
Sbjct: 293 YTKEHNNLILLNKDVQQ--ESSEQKNKSTDKGEKKPDSNEKGERKKEKK------EKTEK 344
Query: 523 EFDESSKTGFKTSTKIKGSDTESE-ESLYKPGAK 555
+FD S K+ K + E E ESL P K
Sbjct: 345 KFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEK 378
Score = 51.2 bits (121), Expect = 3e-06
Identities = 56/298 (18%), Positives = 114/298 (38%), Gaps = 14/298 (4%)
Query: 305 DAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTK 364
D K D+ + + V +V D S E + + ++ +K
Sbjct: 176 DEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASK 235
Query: 365 KYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK 424
K P T++ K+ ++ K+ S D + + T +SE E + ++
Sbjct: 236 KLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLE-----TAPKSE-EFSDLPCPVEE 289
Query: 425 DKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484
K +K N + N + ++ + + KG+K +K +K +KK+ +K + +
Sbjct: 290 IKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHS 349
Query: 485 EMESDLELKKDKKHSKEKK------GSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKI 538
+ D + KD+K +KEK+ S+K+ K + D +S G T
Sbjct: 350 KKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDIT-- 407
Query: 539 KGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKAS 596
S S+ S ++ ++++ SD E K + +T+ + +G+ S
Sbjct: 408 VSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKS 465
Score = 38.1 bits (87), Expect = 0.026
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 15/247 (6%)
Query: 368 ESTDTE-SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK 426
ES + E SG + S + K + +K +A+ I+ E + KE +++E+
Sbjct: 2713 ESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAIS---GHSVEADPKEVEEEERHMP 2769
Query: 427 KDSKTDNKKSVKN--DEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484
K + + S ++ D+ DS + ++ + E K+ D ++ K ++E+
Sbjct: 2770 KRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETN 2829
Query: 485 EMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTG----FKTSTKIKG 540
S + +KD+ S E G K + D ++ D K G + T +K
Sbjct: 2830 STTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKM 2889
Query: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV 600
D ++ +++S +S M+ ES + +++ N+ GE+ V
Sbjct: 2890 KDDSKTDT-----GIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSV 2944
Query: 601 PPSREKP 607
KP
Sbjct: 2945 RRRGRKP 2951
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 84.7 bits (208), Expect = 2e-16
Identities = 118/463 (25%), Positives = 201/463 (43%), Gaps = 61/463 (13%)
Query: 148 VEEKTKRQNEAD-KTPLKSSHENEQSKK-SKSSSETNPESQNSKTVSK--NCSQKDKKDS 203
V ++TK + AD + LK + + SK K S E PE V K K+K
Sbjct: 529 VVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV 588
Query: 204 KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPI-SEICSENSLNVDFLMLVGQSDDESINFD 262
K K TE TK + + SK P+ +E+ + + +V + ++++ +
Sbjct: 589 KKDKPIKTE---TKPSVTEKEVPSKEEPSPVKAEVAEKQATDVK----PKAAKEKTVKKE 641
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK 322
++ + K K + KK+ K KK + E+ K K+VKK +KK++K
Sbjct: 642 TKVKPEDKKEEKEKPKK--EVAKKEDKTPIKKEEKPKKEEVK------KEVKKEIKKEEK 693
Query: 323 K---KDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379
K K+VKK+T + + K+E+K+ KK++K + KK+ KK P KD
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEK-----EPKKEIKKLP----------KD 738
Query: 380 ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDE-KKDKKDSK-TDNKKSV 437
A+ S L +A K K K S +S K +K + K KK+ K + +
Sbjct: 739 AKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAA 798
Query: 438 KNDEESTDADSEPKGDSKKGKKDEKKGKKD--SKKDDKKKDAKK-NAESTEMESD----L 490
+T A G + G E + ++ S +D KD ++ AE ++ D L
Sbjct: 799 VGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQL 858
Query: 491 ELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLY 550
EL +D++ KE + + + + R+ T+ DE T+T+ +G ++ E L
Sbjct: 859 ELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGI-----TTTEGEGECEQTPEEL- 912
Query: 551 KPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGE 593
+P K+ +D+ + K E + GF SS+ + EK E
Sbjct: 913 EPVEKQGVDDIE------KFE--DEGAGFEESSETGDYEEKAE 947
Score = 64.3 bits (155), Expect = 3e-10
Identities = 117/601 (19%), Positives = 239/601 (39%), Gaps = 92/601 (15%)
Query: 49 SRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKT 108
++PL S+ +V + K + E K H ++ PP ++E+ + KT
Sbjct: 549 AKPLPSK-SVRKESKEETPEVTKVNH----------VEKPP-KVESKEKVMVKKDKPIKT 596
Query: 109 HLKKAEYKK---SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKS 165
K + +K SK+E +P+K + +K + +K+ +K + DK K
Sbjct: 597 ETKPSVTEKEVPSKEEP--SPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKE 654
Query: 166 SHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN-------------------S 206
+ E +KK + E + V K ++ KK+ K
Sbjct: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK 714
Query: 207 KKTNTEFLHTKNNPKKDLKR----SKTSNDPISEICSENSLNVDFLMLVGQSDDESINFD 262
K+ E + PKK++K+ +K S+ P+SE +L +ES+ D
Sbjct: 715 KEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKV-----PKKEESVKKD 769
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKK------DSKKVKKN 316
+ + K +K K K + A + + A +K+++
Sbjct: 770 SVAAGKPKEKGK---IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE 826
Query: 317 VKKDDKKKDVKKDTESTDAESGD-SKDERKDTK--KDKKKLKKDD--------KKKDTKK 365
+D+ KD E AE D +KD + + +D++KLK+ + K+++ K
Sbjct: 827 RSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTK 886
Query: 366 YPESTDTE-------SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES-ELESKE 417
P + E G+ + + ++K +D +K + + F SE+ + E K
Sbjct: 887 GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKA 946
Query: 418 SQKDEKKDKKDSK-----TDNKKSVKNDEESTDADSEPKGDSKKGK--KDEKKGKKDSKK 470
++ ++ ++D + + +K S DEES A+++ K+ + + ++D +
Sbjct: 947 ETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDE 1006
Query: 471 DDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
+K +A+++ E + E E +++++ EK ++ + K E+ AE +
Sbjct: 1007 AIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAE----EQY 1062
Query: 531 GFKTS-TKIKGSDTESEE-------SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMS 582
GF T+ TK G+ + E G++ + SD + + E + G+ S
Sbjct: 1063 GFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQS 1122
Query: 583 S 583
+
Sbjct: 1123 T 1123
Score = 55.8 bits (133), Expect = 1e-07
Identities = 61/266 (22%), Positives = 111/266 (41%), Gaps = 22/266 (8%)
Query: 345 KDTKKDKKKLKKDDKKKDTKKYP-ESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
K TK ++ ++ K K P +S ES + +++K K + K+K +
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEK----V 586
Query: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
D + E+K S +++ K+ + K V E D +PK +K K E K
Sbjct: 587 MVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVA---EKQATDVKPKAAKEKTVKKETK 643
Query: 464 GKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH-SKEKKGSKKDIKKDARKD---TES 519
K + KK++K+K K+ A+ K+DK KE+K K+++KK+ +K+ E
Sbjct: 644 VKPEDKKEEKEKPKKEVAK----------KEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK 693
Query: 520 TDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGF 579
+ + + +T K K + + E + KK+I + + S E+K+
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPA 753
Query: 580 RMSSKKTTFNEKGEKASTGRVPPSRE 605
+ K E +K S P +
Sbjct: 754 ALKPKVPKKEESVKKDSVAAGKPKEK 779
Score = 38.1 bits (87), Expect = 0.026
Identities = 42/196 (21%), Positives = 74/196 (37%), Gaps = 32/196 (16%)
Query: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
K LKKD K+K K P + S K + S+ L + K K+ S+D S
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKE-------SSDKVS 2285
Query: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKD 471
+ S + ++ +K K + T K+ + +E+ + + + K K G +
Sbjct: 2286 RVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTT--- 2342
Query: 472 DKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTG 531
K K +A + L+L HS K + D EF + ++
Sbjct: 2343 ---KTTKSSAVPPGLPVYLDLCYIPNHSNSK----------------NVDVEFFKRVRSS 2383
Query: 532 FKTSTKIKGSDTESEE 547
+ + G+D +EE
Sbjct: 2384 YYV---VSGNDPAAEE 2396
Score = 36.2 bits (82), Expect = 0.097
Identities = 80/429 (18%), Positives = 146/429 (34%), Gaps = 30/429 (6%)
Query: 149 EEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKK 208
E ++ Q + T +SS +++ K + N S+ SKT D D K+
Sbjct: 1151 ETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKT--------DATDGKDYNA 1202
Query: 209 TNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNY 268
+ + + + RS + SE+ + +L++ + S+ S + L
Sbjct: 1203 SASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPS 1262
Query: 269 SQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKK 328
+ + L T K S++AE + +DK +V
Sbjct: 1263 PPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVS 1322
Query: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
++S +G + + T + L + +K E DAKD +
Sbjct: 1323 PSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV---PVSFEFSDAKDENERASVSP 1379
Query: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448
D + +K+ S L S E + D+K S + E + S
Sbjct: 1380 MDEPVPDSESPIEKVL------SPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKS 1433
Query: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAK--KNAESTEMESDLELKKDKKHSKEKKGSK 506
K+G D+ + +D + K+ + ++ D +K K E S+
Sbjct: 1434 -----GKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEK-KTDDVEAMSSQ 1487
Query: 507 KDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSA 566
+ D RK + + + D S FK TK+ S+ + P +DE
Sbjct: 1488 PALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATP-----VDEGVAEDT 1542
Query: 567 NSKMEGLES 575
S MEG+ S
Sbjct: 1543 YSHMEGVAS 1551
Score = 32.3 bits (72), Expect = 1.4
Identities = 24/102 (23%), Positives = 45/102 (44%), Gaps = 2/102 (1%)
Query: 110 LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN 169
LKK +K+K +K GT K S K + P + + + +DK +S +
Sbjct: 2235 LKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAAS--PKPAGLKESSDKVSRVASPKK 2292
Query: 170 EQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNT 211
++S + + T PE + ++ K+ K+ ++ SK T
Sbjct: 2293 KESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKT 2334
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 83.6 bits (205), Expect = 5e-16
Identities = 43/211 (20%), Positives = 112/211 (53%), Gaps = 6/211 (2%)
Query: 294 KSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKK 353
+ + E E K+ KK+ + +K +++ +K+ K++ E K+++ + KK++++
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKR--KREREKERKRERGKKEKKGERKKEERE 96
Query: 354 LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESEL 413
KK ++K+ K+ E + + K+ S+ K+ + +++K++ +K + + E
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK---ERERKKEE 153
Query: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK 473
KE ++ E+K ++ + K+ + ++E + + ++ K+ E+K +++ KK+ K
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213
Query: 474 KKDAKKNAESTEMESD-LELKKDKKHSKEKK 503
KK+ +K + +++ E ++ K+ KE+K
Sbjct: 214 KKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 74.3 bits (181), Expect = 3e-13
Identities = 45/225 (20%), Positives = 116/225 (51%), Gaps = 17/225 (7%)
Query: 294 KSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKK 353
+S E E + +K+ KK +++ +K ++++ K+ E +++ + ++ KK+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKRE---------REKERKRERGKKE 85
Query: 354 LKKDDKK--KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
K + KK ++ KK + + G+ K+ R ++ + + K+ +K +
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 412 ELESKESQKDEKKDKKDSKTDNKKSV-KNDEESTDADSEPKGDSKKGKKDEKKGKKDSKK 470
E E K+ ++++++++K+ K +K V + +EE + + + + ++ +K+ KK ++ ++
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKER 205
Query: 471 DDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARK 515
++KK+ KK E + E +KD++ + +K K +K+ +K
Sbjct: 206 RERKKERKKKEERKK-----ERQKDRQTNWREKERGKRERKERKK 245
Score = 74.3 bits (181), Expect = 3e-13
Identities = 51/219 (23%), Positives = 113/219 (51%), Gaps = 18/219 (8%)
Query: 312 KVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPEST- 370
++++ ++ + +K+ KK+ ES + K ER++ +K K++ +K+ K++ KK +
Sbjct: 37 EIREREREIETRKEGKKERES------ERKKERREREKRKREREKERKRERGKKEKKGER 90
Query: 371 DTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSK 430
E + K R + N + K KKK+ K E SKE ++ E+K+++ K
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKK--------ERGRTSKEGKERERKEER--K 140
Query: 431 TDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDL 490
+ +K + +E + + E K K+ +K + +++ K+ ++K+ K+ E + +
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Query: 491 ELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529
E K+ ++ KE+K K++ KK+ +KD ++ E + +
Sbjct: 201 ERKERRERKKERK-KKEERKKERQKDRQTNWREKERGKR 238
Score = 67.0 bits (162), Expect = 5e-11
Identities = 39/183 (21%), Positives = 92/183 (50%), Gaps = 13/183 (7%)
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKD-E 343
K+ ++ KK E + + +K ++ K+N + ++K+K KK+ + S + K+ E
Sbjct: 75 KERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
RK+ +K +++ +++ KK++ +K E + + + K K+ + + KK++ +
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR- 193
Query: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
E + E + ++ E+K ++ K + KK + D ++ + E +GK++ K+
Sbjct: 194 -----KERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKE------RGKRERKE 242
Query: 464 GKK 466
KK
Sbjct: 243 RKK 245
Score = 66.6 bits (161), Expect = 7e-11
Identities = 36/154 (23%), Positives = 78/154 (50%), Gaps = 8/154 (5%)
Query: 282 KYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSK 341
K +++ KK ++ + E E+ + KK KK + K+ K+++ K++ + + + + K
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 342 DERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKAS--------KN 393
E ++ ++++K+ KK ++K+ +K E + E + K + + KK K
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210
Query: 394 DDKKKDAKKITFSTDSESELESKESQKDEKKDKK 427
+ KKK+ +K D ++ KE K E+K++K
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/215 (20%), Positives = 99/215 (46%), Gaps = 12/215 (5%)
Query: 372 TESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT 431
T+ G + R R ++ K K++++++ + E +E ++ ++ KK+ K
Sbjct: 30 TQPGWQSEIREREREIE-TRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKG 88
Query: 432 DNKKSVKNDEESTDADSEPKGDSK-KGKKDEKK--------GKKDSKKDDKKKDAKKNAE 482
+ KK + ++ +G+ K K KK EKK GK+ +K+++K++ +K E
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE 148
Query: 483 STEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD 542
+ E + E +++K K+++ + K++ RK+ E + + E ++ K + K
Sbjct: 149 RKKEEREKE--RERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206
Query: 543 TESEESLYKPGAKKKIDESDGTSANSKMEGLESKR 577
+E K KK+ + T+ K G ++
Sbjct: 207 ERKKERKKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 58.9 bits (141), Expect = 1e-08
Identities = 40/190 (21%), Positives = 89/190 (46%), Gaps = 5/190 (2%)
Query: 410 ESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEK-KGKKDS 468
+SE+ +E + + +K+ K + +K + + E + E + ++GKK++K + KK+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 469 KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGS----KKDIKKDARKDTESTDAEF 524
++ K++ K+N E E E + +K ++ K+G K++ K++ RK+ E E
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 525 DESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSK 584
++ + + + K + EE K ++K E + + E E + + K
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Query: 585 KTTFNEKGEK 594
K ++ +K
Sbjct: 215 KEERKKERQK 224
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/248 (19%), Positives = 96/248 (38%), Gaps = 60/248 (24%)
Query: 112 KAEYKKSKD----------EKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKT 161
+ E KK ++ EK +K+ K++ G E K+ E+ KR+ E +
Sbjct: 48 RKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKEN- 106
Query: 162 PLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPK 221
K E E+ KK + + + K +++++ + KK E K +
Sbjct: 107 --KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE----KERER 160
Query: 222 KDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYT 281
K+ K+ + VG+ ++E
Sbjct: 161 KERKKRERKQ-------------------VGEKEEER----------------------K 179
Query: 282 KYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSK 341
+ +K+ KK + + + E + +++ KK +K KK+++KK+ +KD ++ E K
Sbjct: 180 EKERKERKKRERNRKERKKERERKERRERKKERK--KKEERKKERQKDRQTNWREKERGK 237
Query: 342 DERKDTKK 349
ERK+ KK
Sbjct: 238 RERKERKK 245
Score = 47.8 bits (112), Expect = 3e-05
Identities = 40/260 (15%), Positives = 101/260 (38%), Gaps = 54/260 (20%)
Query: 143 ESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKD 202
E ++ +E + + + E + K E E+ K+ + + K + ++++K
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 203 SKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFD 262
+ K+ K K+ +R +TS +
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKE------------------------------ 129
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK 322
K K + +++ K+ +K + E E + +K ++ + K++++
Sbjct: 130 ----------GKERERKEER-KREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178
Query: 323 KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARN 382
K+ +K+ + + + K ER+ +K++++ KK+ KKK+ +K D ++
Sbjct: 179 KEKERKERKKRERNRKERKKERE--RKERRERKKERKKKEERKKERQKDRQT-------- 228
Query: 383 DSRNLKKASKNDDKKKDAKK 402
N ++ + ++K+ KK
Sbjct: 229 ---NWREKERGKRERKERKK 245
Score = 38.9 bits (89), Expect = 0.015
Identities = 32/169 (18%), Positives = 67/169 (39%), Gaps = 8/169 (4%)
Query: 60 RHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSK 119
R +RK E ++ K R RK +++ + K+ K++K
Sbjct: 55 RESERKKERREREKRKREREKERK-------RERGKKEKKGERKKEERERKKRRREKENK 107
Query: 120 DEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSS 179
+ + KK KK+ G + + ++ EE+ KR+ ++ K E E+ +K +
Sbjct: 108 EGEEKEKRKKKEKKERGRTSKEGKERERKEER-KREERKERERKKEEREKERERKERKKR 166
Query: 180 ETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSK 228
E + + + ++ KK +N K+ E + +K ++ K
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKK 215
Score = 38.9 bits (89), Expect = 0.015
Identities = 27/121 (22%), Positives = 54/121 (44%), Gaps = 19/121 (15%)
Query: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENE 170
K+ + ++ K+E+ K++ +K+ E K+ EK + + E K K E E
Sbjct: 128 KEGKERERKEER-----KREERKE-------RERKKEEREKERERKERKKRERKQVGEKE 175
Query: 171 QSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTS 230
+ +K K E +N K K +K++++ K +K K KK+ ++ + +
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERK-------KKEERKKERQKDRQT 228
Query: 231 N 231
N
Sbjct: 229 N 229
>gi|20070262 TNF receptor-associated factor 3 interacting protein 1
isoform 1 [Homo sapiens]
Length = 691
Score = 82.8 bits (203), Expect = 9e-16
Identities = 85/362 (23%), Positives = 154/362 (42%), Gaps = 32/362 (8%)
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDS-KDE 343
K + K A +S ++ D+K+ +++ +V KN + D ++K+ + S D + + K++
Sbjct: 133 KGEVKGRASLTSRSQELDNKNVREEESRVHKNTE-DRGDAEIKERSTSRDRKQKEELKED 191
Query: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
RK +KDK K K K+ ++ E + E A+ ++ R + ++ D+ + KK
Sbjct: 192 RKPREKDKDKEKA--KENGGNRHREG-ERERAKARARPDNERQKDRGNRERDRDSERKKE 248
Query: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
T + + + +D ++D+ K +++ VKN E S D D E + K +K
Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308
Query: 464 GKKDSKK--DDKKKDAKKNAE---STEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTE 518
+ SKK D KD+K E ST L K K+ SK +K+ +
Sbjct: 309 SGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKE---------D 359
Query: 519 STDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRG 578
+ A+ +S +G +T + E K SD SA+ + E ++
Sbjct: 360 NISAKSLDSIVSGINNE---PNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPT 416
Query: 579 FRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRY 638
+ T+ + +G+ G+ E P P P+ S +RR+ P P R
Sbjct: 417 EKQKGDSTS-DAEGDAGPAGQ--DKSEVPETPEI-PNELSSNIRRI------PRPGSARP 466
Query: 639 AP 640
AP
Sbjct: 467 AP 468
Score = 56.2 bits (134), Expect = 9e-08
Identities = 85/453 (18%), Positives = 178/453 (39%), Gaps = 28/453 (6%)
Query: 83 KILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDS-KKKGGSYATN 141
K+++ PP+ + PFR+L+ T + + K +K D+ K K +
Sbjct: 15 KVIRRPPLTEKLLSKPPFRYLHDIITEVIRMT-GFMKGLYTDAEMKSDNVKDKDAKISFL 73
Query: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSK---SSSETNPESQNSKTVSKNCSQK 198
++ +V + A + + HE E++ + N S + +K
Sbjct: 74 QKAIDVVVMVSGEPLLAKPARIVAGHEPERTNELLQIIGKCCLNKLSSDDAVRRVLAGEK 133
Query: 199 DKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDES 258
+ + S + ++ L KN +++ + K + D E S + D + E
Sbjct: 134 GEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRD------RKQKEE 187
Query: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVK 318
+ D R ++ K K+ N + + E ++ + ++ + +
Sbjct: 188 LKEDRKPREKDKDKEK----------AKENGGNRHREGERERAKARARPDNERQKDRGNR 237
Query: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAK 378
+ D+ + KK+TE +E G K+ +D +D+++ + K +D ++ + D +
Sbjct: 238 ERDRDSERKKETE-RKSEGGKEKERLRD--RDRERDRDKGKDRDRRRVKNGEHSWDLDRE 294
Query: 379 DARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK-DKKDSKTDNKKSV 437
R + KK++ + + K TF DS++E E++ S + K K SK +K SV
Sbjct: 295 KNREHDKPEKKSASSGEMSKKLSDGTFK-DSKAETETEISTRASKSLTTKTSKRRSKNSV 353
Query: 438 KNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKK 497
+ +E D S DS + + ++ + + K+A N+ S ++ L+ +
Sbjct: 354 EGRKE--DNISAKSLDSIVSGINNEPNQETTTSEIGTKEANINSTSISDDNSASLRCENI 411
Query: 498 HSKEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
+ K D DA D + E +T
Sbjct: 412 QPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPET 444
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/227 (21%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 373 ESGDAKD-ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT 431
E G+ K A SR+ + +KN +++ ++ +T+ + E KE + +D+K
Sbjct: 132 EKGEVKGRASLTSRSQELDNKN--VREEESRVHKNTEDRGDAEIKE--RSTSRDRK---- 183
Query: 432 DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLE 491
K+ +K D + + D + + + G ++G+++ K + D ++ + E D +
Sbjct: 184 -QKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRD 242
Query: 492 LKKDKKHSKEKKGSK-------KDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
++ K+ ++ +G K +D ++D K + + K + D
Sbjct: 243 SERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKP 302
Query: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEK 591
++S KK+ SDGT +SK E E++ R S TT K
Sbjct: 303 EKKSASSGEMSKKL--SDGTFKDSKAE-TETEISTRASKSLTTKTSK 346
Score = 37.7 bits (86), Expect = 0.033
Identities = 75/366 (20%), Positives = 149/366 (40%), Gaps = 67/366 (18%)
Query: 153 KRQNEADKTPLKSSHENEQSKK--------SKSSSETNPESQNSKTV--------SKNCS 196
++ E DK KS+ E SKK SK+ +ET ++ SK++ SKN
Sbjct: 294 EKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSV 353
Query: 197 QKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDD 256
+ K+D+ ++K ++ N P ++ T+++ ++ + NS ++ SDD
Sbjct: 354 EGRKEDNISAKSLDSIVSGINNEPNQE----TTTSEIGTKEANINSTSI--------SDD 401
Query: 257 ESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN 316
S + N N ++ K+ +SDAE D+ A +D +V +
Sbjct: 402 NSASLRC--ENIQPNPTE--------------KQKGDSTSDAEG-DAGPAGQDKSEVPET 444
Query: 317 VK-KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG 375
+ ++ ++++ A + +R+D+ + L+ D + + K + TES
Sbjct: 445 PEIPNELSSNIRRIPRPGSARPAPPRVKRQDS---MEALQMD--RSGSGKTVSNVITESH 499
Query: 376 DAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKK 435
++ D D + + +A+ + + + +T ELE +E K ++K D +K
Sbjct: 500 NS-DNEEDDQFVVEAAPQLSEMSEIEMVT-----AVELEEEEKHGGLVKKILETKKDYEK 553
Query: 436 SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKD 495
PK K+ E KK+ K+ + + + T +S L L K
Sbjct: 554 ----------LQQSPKPGEKERSLFESAWKKEKDIVSKEIEKLRTSIQTLCKSALPLGKI 603
Query: 496 KKHSKE 501
+ +E
Sbjct: 604 MDYIQE 609
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/483 (20%), Positives = 213/483 (44%), Gaps = 65/483 (13%)
Query: 148 VEEKTKRQNEADKTPLKSS------------HENEQSKKSKSSSETNP--ESQNSKTVSK 193
++E +RQ E D T +S ENE ++K + S E + ++TV+K
Sbjct: 111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK 170
Query: 194 NCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQ 253
+ + D +D++ +KK + E K + P EN + V +
Sbjct: 171 SYQKNDWRDAEENKKEDKE------------KEEEEEEKPKRGSIGENQVEVMVEEKTTE 218
Query: 254 SDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKV 313
S +E++ L+N Q +S+ + + D + +K + + E ++ + +
Sbjct: 219 SQEETVVMS--LKN-GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE 275
Query: 314 KKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTE 373
++ K ++ K + + +AE + ER+ + ++++ ++++K+ ++ + E
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE 335
Query: 374 SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDN 433
A++ + K+A++ + K+ E + ++E Q+ ++++ +K +
Sbjct: 336 KRAAEERQRIKEEEKRAAEERQRIKE----------EEKRAAEERQRARAEEEEKAKVEE 385
Query: 434 KKSVKNDEESTDADSEPKGDSKKGKKDEKK--GKKDSKK---DDKKKDAKKNAESTEMES 488
+K K EE A E K KG+K E+K GK ++K +DK + A + E +
Sbjct: 386 QKRNKQLEEKKHAMQETK---IKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGT 442
Query: 489 DLELKKDKKHSKEKKGSKKDIKKD-ARKDTE-STDAEFDESSKTGFKTSTKIKGSDTE-- 544
++ K++K + K++IK + +KD E + + K GF T++K + E
Sbjct: 443 KVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGF---TEVKSQNGEFM 499
Query: 545 ------SEESLYKPGAKKKID--ESDG---TSANSKMEGLESKRGFRMSSKKTTFNEKGE 593
+E + +PG + +D E++G A ++E L +RG S + +K +
Sbjct: 500 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 559
Query: 594 KAS 596
+A+
Sbjct: 560 EAA 562
Score = 64.7 bits (156), Expect = 3e-10
Identities = 95/567 (16%), Positives = 231/567 (40%), Gaps = 36/567 (6%)
Query: 65 KLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGG 124
+L ++ K ++ + + ++ P T A P R + + E ++ + +
Sbjct: 99 RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 158
Query: 125 TPLKKDSKKKGGSYATNP-----ESKQIVEEKTKRQNEADKTPLKSSHENE-----QSKK 174
++++ SY N E+K+ E+K K + E +K S EN+ + K
Sbjct: 159 RYEIEETETVTKSYQKNDWRDAEENKK--EDKEKEEEEEEKPKRGSIGENQVEVMVEEKT 216
Query: 175 SKSSSETNPES-QNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDP 233
++S ET S +N + S+ Q+++++ + + ++ E + ++ + + +R++ +
Sbjct: 217 TESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEE 276
Query: 234 ISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAK 293
I +E + ++++++ + R + K ++ K+ K
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEK 336
Query: 294 KSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKK-DKK 352
++++ E + K+ +K + + ++ +K+++K+ ++ + E +E+K K+ ++K
Sbjct: 337 RAAE-ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEK 395
Query: 353 KLKKDDKKKDTKKYPESTDTESGDAKDARNDSRN---LKKASKNDDKKKDAKKITFSTDS 409
K + K +K + + + + K A+ D LKK + K AK+ D
Sbjct: 396 KHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455
Query: 410 -------------ESELESKE---SQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGD 453
+ + E KE S D KK + K+ N + + + + T+ G
Sbjct: 456 PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515
Query: 454 SKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDA 513
E +G + + ++ ++ TE E +LK+ ++ + + K +++
Sbjct: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
Query: 514 RKDTESTD-AEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEG 572
RK E + E + + + + E E + K++ DG S + K
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
Query: 573 LESKRGFRMS-SKKTTFNEKGEKASTG 598
+ +G + ++ F K + S+G
Sbjct: 636 CFTPKGSSLKIEERAEFLNKSVQKSSG 662
Score = 54.7 bits (130), Expect = 3e-07
Identities = 69/337 (20%), Positives = 147/337 (43%), Gaps = 36/337 (10%)
Query: 286 KDTKKNAKKSSDAESED-SKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDER 344
K T N + D E+ + A+++ ++ K+ + +++K+ D TDA
Sbjct: 80 KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF--DPTITDASLSLPSRRM 137
Query: 345 KDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKIT 404
++ + + +K++K + ++ E +TE+ +ND R+ ++ K D +K++ ++
Sbjct: 138 QNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEK 197
Query: 405 FSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKK--GKKDEK 462
S E E +EK + +T S+KN + S++ EPK + ++ G +
Sbjct: 198 PKRGSIGE-NQVEVMVEEKTTESQEETV-VMSLKNGQISSE---EPKQEEEREQGSDEIS 252
Query: 463 KGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA 522
+K ++D ++ +A++ E ++ ++DKK + E+ + + +K A ++ E +A
Sbjct: 253 HHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE-EKAAAQERERREA 311
Query: 523 E----FDESSKTGFKTSTKIKGSDTES--------EESLYKPGAKKKIDESDGTSANSKM 570
E E K + +IK + + EE +++I E + +A +
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371
Query: 571 EGL----------ESKRGFRMSSKKTTFNE---KGEK 594
E KR ++ KK E KGEK
Sbjct: 372 RARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEK 408
Score = 53.1 bits (126), Expect = 8e-07
Identities = 61/318 (19%), Positives = 136/318 (42%), Gaps = 32/318 (10%)
Query: 286 KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKD--E 343
++ ++ A++ + ++ + + + +V+ N + ++ K T +T E D E
Sbjct: 39 RERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE 98
Query: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
R ++++++ + + + K++ D DA + R ++N+ +K
Sbjct: 99 RLARREERRQKRLQEALERQKEF----DPTITDASLSLPSRRMQNDTAENETTEK----- 149
Query: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
E K + E+ + ++++T K KND DA+ K D +K +++E+K
Sbjct: 150 ----------EEKSESRQERYEIEETETVTKSYQKNDWR--DAEENKKEDKEKEEEEEEK 197
Query: 464 GKKDSKKDDKKK--DAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTD 521
K+ S +++ + +K ES E + LK + S+E K++ +++ D S
Sbjct: 198 PKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEE---PKQEEEREQGSDEISHH 254
Query: 522 AEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRM 581
+ +E K + + + E E + KK DE A K E +R R
Sbjct: 255 EKMEEEDKE--RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER--RE 310
Query: 582 SSKKTTFNEKGEKASTGR 599
+ ++ E+ ++A+ R
Sbjct: 311 AEERERMREEEKRAAEER 328
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/350 (22%), Positives = 142/350 (40%), Gaps = 40/350 (11%)
Query: 267 NYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDV 326
N S NS + S K K++ K+ K+ + E + +++ + K+ K+ K++
Sbjct: 1252 NSSNGNSGSNS---NKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERP 1308
Query: 327 KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRN 386
KD ++ + + K +++ K K++ KD+K K T ES T+ + + + R+
Sbjct: 1309 NKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
Query: 387 LKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK----------------KDSK 430
+ K K+ + K +K S +S + + + E++ K KDS
Sbjct: 1369 IAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSL 1428
Query: 431 TDNKKS-----VKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
+ K+S + + E + D K K ++ ++ KKD+K + +K S
Sbjct: 1429 IELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS-- 1486
Query: 486 MESDLELKKD-KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
+D E+ D K KE+ G+ K + ES + K K+S K KGSD+
Sbjct: 1487 -NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSF 1545
Query: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEK 594
E + D S+ K E K K+ + K EK
Sbjct: 1546 KSEKM------------DKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
Score = 76.3 bits (186), Expect = 8e-14
Identities = 99/425 (23%), Positives = 174/425 (40%), Gaps = 70/425 (16%)
Query: 123 GGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETN 182
GG P S GS + + ES E+T + E + +K+ ++ + +SS N
Sbjct: 1205 GGGP----SSSSIGSASKSDESST---EETDKSRERSQCGVKAVNKASSTTPKGNSSNGN 1257
Query: 183 PESQNSKTVSKNCSQKDKKDSKNSKK----TNTEFLHTKNNPKKDLKRSKTSNDPISEIC 238
S ++K V +N +K K+ K K+ T E + K+ K + + D +
Sbjct: 1258 SGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET 1317
Query: 239 SENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDA 298
E + +SD E F K K K+ K T NA+ S
Sbjct: 1318 KERT---------PKSDKEKEKF-----------KKEEKAKDEKF--KTTVPNAESKSTQ 1355
Query: 299 ESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE--RKDTKKDKKKLKK 356
E E K+ ++ +++ K+ K K+ K E T SG K R D + +++ K+
Sbjct: 1356 EREREKEPSRE-----RDIAKEMKSKENVKGGEKTPV-SGSLKSPVPRSDIPEPEREQKR 1409
Query: 357 DDKKKDTKKYPESTDTESGDAKDARNDSRNL------KKASKNDDKKKDAKKITFSTDSE 410
+K DT P + T + + S L SK+ +++ D K + S +
Sbjct: 1410 --RKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS 1467
Query: 411 SELESKESQKDEKKDKKDSKTDNKK------SVKNDEESTDADSEPKGDSK-----KGKK 459
E E K+ +KD K+ K+D ++++ + +E T S+ K +S +K
Sbjct: 1468 REREKKD-EKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEK 1526
Query: 460 DEKKGKKDSKKDDKKKDAKKNAESTEMES--------DLELKKDKKHSKEKKGSKKDIKK 511
D++K K S +K D+ K+ + ++ S D E K +KK ++ G K++ K
Sbjct: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE-KIEKKEKRDSSGGKEEKKH 1585
Query: 512 DARKD 516
D
Sbjct: 1586 HKSSD 1590
Score = 68.2 bits (165), Expect = 2e-11
Identities = 83/335 (24%), Positives = 138/335 (41%), Gaps = 44/335 (13%)
Query: 107 KTHLKKAEYKKSKDEKGGTP--------LKKDSKKKGGSYATNPESK--QIVEEKTKRQN 156
K + K+ +K K++K TP L KD K+K N + K + E K
Sbjct: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326
Query: 157 EADKTPLKSSHENEQSK------KSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTN 210
E +K + ++E+ K +SKS+ E E + S+ K K++ K +KT
Sbjct: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
Query: 211 TEFLHTKNNPKKDL-------KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDA 263
P+ D+ KR K P S +S D L+ + +S +
Sbjct: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSP---SHSSTVKDSLIELKESSAK-----L 1438
Query: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKD---AKKDSKKVKKNVKKD 320
++ + SK+ K + KKD K+ ++S + E +D KD K+D + V D
Sbjct: 1439 YINHTPPPLSKS---KEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPD 1495
Query: 321 -DKKKDVKKDTESTDAESGDSKDE-----RKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
K++ + T +S E KD +K+K K +K D+ K + S
Sbjct: 1496 LTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISS 1555
Query: 375 GDAKDARNDSRNLKKASKNDDK-KKDAKKITFSTD 408
G K++R+D ++K K D K+ KK S+D
Sbjct: 1556 GGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
Score = 65.5 bits (158), Expect = 1e-10
Identities = 81/369 (21%), Positives = 154/369 (41%), Gaps = 76/369 (20%)
Query: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDER-KDTKK 349
+A KS ++ +E++ +++ S+ VK +K S++ SG + ++ K+ K
Sbjct: 1215 SASKSDESSTEETDKSRERSQC---GVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDK 1271
Query: 350 DKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDS 409
+K K K+ +KK+ T D K+ + R K D+K ++ K+ T +D
Sbjct: 1272 EKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK-----DEKARETKERTPKSDK 1326
Query: 410 ESE-------------------LESKESQKDEKKDKKDSKTD------NKKSVKNDEEST 444
E E ESK +Q+ E++ + + D +K++VK E++
Sbjct: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
Query: 445 DADS----EPKGDSKKGKKDEKKGK-------------KDSKKDDKKKDAK--------- 478
+ S P+ D + ++++K+ K KDS + K+ AK
Sbjct: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446
Query: 479 --KNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTST 536
K+ E + DL+ +++ +EKK K +K+ ++D + D E K
Sbjct: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKD--RKERKRDHSNNDREVPPDLTKRRKEEN 1504
Query: 537 KIKG-SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKA 595
G S +SE P +K E + + ++ K +G +S + +EK +K
Sbjct: 1505 GTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFK-----------SEKMDKI 1553
Query: 596 STGRVPPSR 604
S+G SR
Sbjct: 1554 SSGGKKESR 1562
Score = 65.5 bits (158), Expect = 1e-10
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 37/344 (10%)
Query: 116 KKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEE-----KTKRQNEADK-------TPL 163
K++ EKG +K+ +KK + AT PE++ + ++ K +R N+ +K TP
Sbjct: 1267 KENDKEKGK---EKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTP- 1322
Query: 164 KSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKD 223
KS E E+ KK + + + ++ SK+ +++++ + ++ + + +K N K
Sbjct: 1323 KSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGG 1382
Query: 224 LKR----SKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLK 279
K S S P S+I + S S L ++++K Y
Sbjct: 1383 EKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI-- 1440
Query: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK-KKDVKKDTESTDAESG 338
T KS + E D KD K ++ ++ KKD+K +K+ K+D + D E
Sbjct: 1441 ------NHTPPPLSKSKEREM-DKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVP 1493
Query: 339 DSKDERKDTKKDKKKLKKDDKKKDTKK-YPESTDTESGDAKDARNDSRNLKKASKNDDKK 397
+R+ + + K + + YP D E +K + K+ + K
Sbjct: 1494 PDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG------KEKGSDSFKS 1547
Query: 398 KDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
+ KI+ ES + ++ +K EK+D K + K +D+
Sbjct: 1548 EKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/194 (26%), Positives = 93/194 (47%), Gaps = 23/194 (11%)
Query: 332 STDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKAS 391
S+ S DE + DK + + K K S+ T G++ + + S + K
Sbjct: 1210 SSSIGSASKSDESSTEETDKSRERSQCGVKAVNK--ASSTTPKGNSSNGNSGSNSNKAVK 1267
Query: 392 KND-----DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA 446
+ND +K+K+ K+ T +T E+ + K+ K++ K+++ +K + + K
Sbjct: 1268 ENDKEKGKEKEKEKKEKTPATTPEARVLGKDG-KEKPKEERPNKDEKARETK-------- 1318
Query: 447 DSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSK 506
+ PK D +K EK K++ KD+K K NAES +S E +++K+ S+E+ +K
Sbjct: 1319 ERTPKSDKEK----EKFKKEEKAKDEKFKTTVPNAES---KSTQEREREKEPSRERDIAK 1371
Query: 507 KDIKKDARKDTEST 520
+ K+ K E T
Sbjct: 1372 EMKSKENVKGGEKT 1385
Score = 48.1 bits (113), Expect = 2e-05
Identities = 78/345 (22%), Positives = 134/345 (38%), Gaps = 68/345 (19%)
Query: 38 PKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQ 97
PK + ++K+R K + + +K K ++ +K + + + + RE+
Sbjct: 1303 PKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNA-ESKSTQEREREK 1361
Query: 98 TPFRHLYTSKTHLKKAEYKKSKDEKGG--TPLKKDSKKKGGSYATNPESKQIVEEKTKRQ 155
P R +K E K ++ KGG TP+ S K + PE ++ E+ +R+
Sbjct: 1362 EPSRERDIAK------EMKSKENVKGGEKTPVS-GSLKSPVPRSDIPEPER---EQKRRK 1411
Query: 156 NEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQK-DKKDSKNSKKTNTEFL 214
+ +P SS + + K SS + +SK+ ++ DKKD S++ + E
Sbjct: 1412 IDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSRERE 1471
Query: 215 HTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSK 274
+K+ KR ++ND + D R +N +
Sbjct: 1472 KKDEKDRKERKRDHSNND------------------------REVPPDLTKRRKEENGTM 1507
Query: 275 NYSLKYTKY-------TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327
S ++ +KD +KN KSS E K D K K
Sbjct: 1508 GVSKHKSESPCESPYPNEKDKEKNKSKSSGKE------------------KGSDSFKSEK 1549
Query: 328 KDTESTDAESGDSKDERKDTKKDKKKLKKDDK-KKDTKKYPESTD 371
D S SG K+ R D +K +KK K+D K+ KK+ +S+D
Sbjct: 1550 MDKIS----SGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/171 (21%), Positives = 72/171 (42%), Gaps = 7/171 (4%)
Query: 406 STDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGK 465
S+ S +S ES +E ++ K+V +T + G+S K
Sbjct: 1210 SSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKEN 1269
Query: 466 KDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFD 525
K +K+K+ K+ +T E+ + K K+ KE++ +K + ++ ++ T +D E +
Sbjct: 1270 DKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKE 1329
Query: 526 ESSK------TGFKTST-KIKGSDTESEESLYKPGAKKKIDESDGTSANSK 569
+ K FKT+ + T+ E +P ++ I + + N K
Sbjct: 1330 KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 81.3 bits (199), Expect = 3e-15
Identities = 79/323 (24%), Positives = 144/323 (44%), Gaps = 29/323 (8%)
Query: 295 SSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE---RKDTKKDK 351
+ D+ S+++ D + S +K ++K+ V + S+D+E+ DS DE + K K
Sbjct: 55 TEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKK 114
Query: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
K +K +KK KK T + KD+ +S ++ +D D+ + S+DS+S
Sbjct: 115 GKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD---SDSNSSSSSSDSDS 171
Query: 412 ELESKESQKDEKKDKKDSKTDN---KKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS 468
E +E +D + D ++ + + E + K + K + + KK K +
Sbjct: 172 SSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTA 231
Query: 469 KKDDKKKDAKKNAESTEMESDLELKKDK--KHSKEKKGSKKDIKKDARKDT-ESTDAEFD 525
KK +KK+ KK E E + ++++ + H+KE++ SK+D K D + E AE +
Sbjct: 232 KKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERR-SKRDEKLDKKSQAMEELKAERE 290
Query: 526 E---------SSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
+ + K KTS ++ D E EE K ++SD +S S + E K
Sbjct: 291 KRKNRTAELLAKKQPLKTS-EVYSDDEEEEED------DKSSEKSDRSSRTSSSDEEEEK 343
Query: 577 RGFRMSSKKTTFNEKGEKASTGR 599
S+ + E+ + R
Sbjct: 344 EEIPPKSQPVSLPEELNRVRLSR 366
Score = 68.6 bits (166), Expect = 2e-11
Identities = 71/337 (21%), Positives = 142/337 (42%), Gaps = 25/337 (7%)
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGD 376
VKK +K V D+++ D+ S ++ D+ + +K+ ++K+ + S+D+E+ D
Sbjct: 42 VKK--RKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSD 99
Query: 377 AKD----ARNDSRNLKKASKNDDK---KKDAKKITFS--TDSESELESKESQKDEKKD-- 425
+ D N ++ KA K + K KK A K S +D +S ES ++ E D
Sbjct: 100 SDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSD 159
Query: 426 -KKDSKTDNKKSVKNDEESTDADSEP-KGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAES 483
S + + S DEE D E GD + + E+ +K+ +++ + K+
Sbjct: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
Query: 484 TEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDT 543
E +LK KK K++K K++ +++ +K T+ +++ +K + +
Sbjct: 220 RRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKS 279
Query: 544 ESEESLYKPGAKKKIDESDGTSANSKM----------EGLESKRGFRMSSKKTTFNEKGE 593
++ E L K+K ++ + + E E + S + + + E
Sbjct: 280 QAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDE 339
Query: 594 KASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMP 630
+ +PP + LP + + + WC MP
Sbjct: 340 EEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMP 376
Score = 63.5 bits (153), Expect = 6e-10
Identities = 68/298 (22%), Positives = 120/298 (40%), Gaps = 23/298 (7%)
Query: 269 SQNNSKNYSLKYTKYTKKDTK-KNAKKSSDAESEDSKDAKKDSKKV---KKNVKKD---- 320
S N L K + D++ K S A S DS+ + D + KN KK
Sbjct: 60 SDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARK 119
Query: 321 -DKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379
+KK +KK T + KD ++ ++ D D+ S+D++S +
Sbjct: 120 IEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD---SDSNSSSSSSDSDSSSEDE 176
Query: 380 ARNDSRNLKKASKNDDKKKDAKKITFSTDSE--SELESKESQKDEKKDKKDSKTDNKKSV 437
+D +D+ + + + E + +E +E K + KK KT KK
Sbjct: 177 EFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEK 236
Query: 438 KNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKK 497
K ++ + + E K K + E + +K+ K+D K + +S ME ELK +++
Sbjct: 237 KEKKKKQEEEQEKK---KLTQIQESQVTSHNKERRSKRDEKLDKKSQAME---ELKAERE 290
Query: 498 HSKEKKG---SKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKP 552
K + +KK K + ++ + E D+ S S++ SD E E+ P
Sbjct: 291 KRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPP 348
Score = 52.4 bits (124), Expect = 1e-06
Identities = 58/287 (20%), Positives = 122/287 (42%), Gaps = 26/287 (9%)
Query: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK 201
P S+ ++ + D+ S+ ++ K K + + Q +KT S S KD
Sbjct: 85 PVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKD-S 143
Query: 202 DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261
+++S E + +N S +S+D S E + L+G +D +
Sbjct: 144 SAESSAPEEGEVSDSDSN------SSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA--- 194
Query: 262 DAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321
R + + + K++ K + + K AKK KK KK KK +
Sbjct: 195 ----RLEQMTEKEREQELFNRIEKREVLKRRFEI----KKKLKTAKKKEKKEKK--KKQE 244
Query: 322 KKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381
++++ KK T+ +++ ER+ +K+D+K KK ++ K E + + +
Sbjct: 245 EEQEKKKLTQIQESQVTSHNKERR-SKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKK 303
Query: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKD 428
+ + S ++++++D K + +S+ S+ S DE+++K++
Sbjct: 304 QPLKTSEVYSDDEEEEEDDK-----SSEKSDRSSRTSSSDEEEEKEE 345
Score = 36.2 bits (82), Expect = 0.097
Identities = 29/148 (19%), Positives = 69/148 (46%), Gaps = 3/148 (2%)
Query: 90 IYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
++ ++ + + K LK A+ KK K EK ++ KKK + + E
Sbjct: 208 LFNRIEKREVLKRRFEIKKKLKTAK-KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE 266
Query: 150 EKTKRQNEAD-KTPLKSSHENEQSKKSKSSSETNPESQNSKTVS-KNCSQKDKKDSKNSK 207
++KR + D K+ + E+ K+ ++E + Q KT + +++++D K+S+
Sbjct: 267 RRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
Query: 208 KTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
K++ + ++ +++ + + P+S
Sbjct: 327 KSDRSSRTSSSDEEEEKEEIPPKSQPVS 354
Score = 29.6 bits (65), Expect = 9.1
Identities = 55/285 (19%), Positives = 111/285 (38%), Gaps = 31/285 (10%)
Query: 96 EQTPFRHLYTSKTHLKKAEYKKSKDE--KGGTPL--------KKDSKKKGGSYATNPESK 145
+Q FR + S ++E+ K K+ G L K+ S K+ +Y N +
Sbjct: 433 DQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQD- 491
Query: 146 QIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQ-KDKKDSK 204
+EE K + K P + + Q K K+ +E + +K + ++ +++ ++
Sbjct: 492 --IEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEAL 549
Query: 205 NSKKT-NTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFL-------MLVGQSDD 256
+ ++T N + N ++ ++ ++E + + +D +V S D
Sbjct: 550 DRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRD 609
Query: 257 ESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN 316
++ +Q N+K Y K+ K K D S+ + D +D K
Sbjct: 610 PAVQ----AAILAQLNAK-YGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFK---- 660
Query: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKK 361
V D K D++ + + A + SK ++ L +D KK
Sbjct: 661 VHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKK 705
>gi|213385278 TNF receptor-associated factor 3 interacting protein 1
isoform 2 [Homo sapiens]
Length = 625
Score = 80.9 bits (198), Expect = 3e-15
Identities = 72/308 (23%), Positives = 136/308 (44%), Gaps = 16/308 (5%)
Query: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDS-KDE 343
K + K A +S ++ D+K+ +++ +V KN + D ++K+ + S D + + K++
Sbjct: 133 KGEVKGRASLTSRSQELDNKNVREEESRVHKNTE-DRGDAEIKERSTSRDRKQKEELKED 191
Query: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
RK +KDK K K K+ ++ E + E A+ ++ R + ++ D+ + KK
Sbjct: 192 RKPREKDKDKEKA--KENGGNRHREG-ERERAKARARPDNERQKDRGNRERDRDSERKKE 248
Query: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
T + + + +D ++D+ K +++ VKN E S D D E + K +K
Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308
Query: 464 GKKDSKK--DDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTD 521
+ SKK D KD+K TE E K K+ SK ++ D+ D E D
Sbjct: 309 SGEMSKKLSDGTFKDSK---AETETEISTRASKSLTTKTSKRRSKNSVEGDSTSDAEG-D 364
Query: 522 AEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRM 581
A K+ + +I + + + +PG+ + + + +E+ + R
Sbjct: 365 AGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSAR-----PAPPRVKRQDSMEALQMDRS 419
Query: 582 SSKKTTFN 589
S KT N
Sbjct: 420 GSGKTVSN 427
Score = 55.1 bits (131), Expect = 2e-07
Identities = 74/379 (19%), Positives = 153/379 (40%), Gaps = 27/379 (7%)
Query: 83 KILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDS-KKKGGSYATN 141
K+++ PP+ + PFR+L+ T + + K +K D+ K K +
Sbjct: 15 KVIRRPPLTEKLLSKPPFRYLHDIITEVIRMT-GFMKGLYTDAEMKSDNVKDKDAKISFL 73
Query: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSK---SSSETNPESQNSKTVSKNCSQK 198
++ +V + A + + HE E++ + N S + +K
Sbjct: 74 QKAIDVVVMVSGEPLLAKPARIVAGHEPERTNELLQIIGKCCLNKLSSDDAVRRVLAGEK 133
Query: 199 DKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDES 258
+ + S + ++ L KN +++ + K + D E S + D + E
Sbjct: 134 GEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRD------RKQKEE 187
Query: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVK 318
+ D R ++ K K+ N + + E ++ + ++ + +
Sbjct: 188 LKEDRKPREKDKDKEK----------AKENGGNRHREGERERAKARARPDNERQKDRGNR 237
Query: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAK 378
+ D+ + KK+TE +E G K+ +D +D+++ + K +D ++ + D +
Sbjct: 238 ERDRDSERKKETE-RKSEGGKEKERLRD--RDRERDRDKGKDRDRRRVKNGEHSWDLDRE 294
Query: 379 DARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK-DKKDSKTDNKKSV 437
R + KK++ + + K TF DS++E E++ S + K K SK +K SV
Sbjct: 295 KNREHDKPEKKSASSGEMSKKLSDGTFK-DSKAETETEISTRASKSLTTKTSKRRSKNSV 353
Query: 438 KNDEES-TDADSEPKGDSK 455
+ D S + D+ P G K
Sbjct: 354 EGDSTSDAEGDAGPAGQDK 372
Score = 53.1 bits (126), Expect = 8e-07
Identities = 83/433 (19%), Positives = 165/433 (38%), Gaps = 76/433 (17%)
Query: 150 EKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKT 209
EK + + A T +N+ ++ +S N E + + + + +D+K + K+
Sbjct: 132 EKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKED 191
Query: 210 NTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYS 269
R D E EN N + + E A N
Sbjct: 192 ----------------RKPREKDKDKEKAKENGGNRH-----REGERERAKARARPDNER 230
Query: 270 QNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKD 329
Q + N KK+T++ ++ + E +D ++D K KD ++ VK
Sbjct: 231 QKDRGNRERDRDSERKKETERKSEGGKEKERLRDRDRERDRDK-----GKDRDRRRVKNG 285
Query: 330 TESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKK 389
S D D K+ + DK + K + +KK + T +S + +R K
Sbjct: 286 EHSWDL------DREKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKS 339
Query: 390 ASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSE 449
+ K++ + + S++E ++ + +D+ + + + N+ S +
Sbjct: 340 LTTKTSKRRSKNSVEGDSTSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSAR 399
Query: 450 P------KGDSKKGKKDEKKG-------------KKDSKKDDK--KKDAKKNAESTEME- 487
P + DS + + ++ G D+++DD+ + A + +E +E+E
Sbjct: 400 PAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMSEIEM 459
Query: 488 -SDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESE 546
+ +EL++++KH G K I + +KD E + +S K G E E
Sbjct: 460 VTAVELEEEEKHG----GLVKKI-LETKKDYE----KLQQSPKPG------------EKE 498
Query: 547 ESLYKPGAKKKID 559
SL++ KK+ D
Sbjct: 499 RSLFESAWKKEKD 511
Score = 50.1 bits (118), Expect = 7e-06
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 41/290 (14%)
Query: 373 ESGDAKD-ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT 431
E G+ K A SR+ + +KN +++ ++ +T+ + E KE + +D+K
Sbjct: 132 EKGEVKGRASLTSRSQELDNKN--VREEESRVHKNTEDRGDAEIKE--RSTSRDRK---- 183
Query: 432 DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLE 491
K+ +K D + + D + + + G ++G+++ K + D ++ + E D +
Sbjct: 184 -QKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRD 242
Query: 492 LKKDKKHSKEKKGSK-------KDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
++ K+ ++ +G K +D ++D K + + K + D
Sbjct: 243 SERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKP 302
Query: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEK--------GEKAS 596
++S KK+ SDGT +SK E E++ R S TT K G+ S
Sbjct: 303 EKKSASSGEMSKKL--SDGTFKDSKAE-TETEISTRASKSLTTKTSKRRSKNSVEGDSTS 359
Query: 597 TGR---VPPSREKPPLPACEPSLP---SPKVRRLCWCKMPPPPPKPRYAP 640
P ++K +P P +P S +RR+ P P R AP
Sbjct: 360 DAEGDAGPAGQDKSEVPE-TPEIPNELSSNIRRI------PRPGSARPAP 402
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 80.9 bits (198), Expect = 3e-15
Identities = 78/387 (20%), Positives = 161/387 (41%), Gaps = 28/387 (7%)
Query: 109 HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYA---TNPESKQIVEEKTKRQNEADKT--PL 163
H K+ E +K + E+ + + K+ S + +V EK + NE P
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
Query: 164 KSSHENEQSKKSKS-SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKK 222
K E E+ +S+S SS + S NS+T S + + S +S + T ++++ K
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTS---SRSSSPK 553
Query: 223 DLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTK 282
KR S P + S + + + ES +R+ ++N +
Sbjct: 554 RKKRHSRSRSPTIKARRSRSRSYSRRIKI-----ESNRARVKIRDRRRSNRNSI------ 602
Query: 283 YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKD 342
+++ ++N S + S+ + + + ++ +D +K D ++ S ++ +
Sbjct: 603 --ERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660
Query: 343 ERKDTKKDKKK-LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAK 401
+ ++ KK++ + + KD KKKD ++ + E K+ + K S DD+ K +
Sbjct: 661 KEQERKKERSRSIDKDRKKKDKER-----EREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715
Query: 402 KITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDE 461
+ + + K + D ++D K S T + K + S + SE G SK+ K +
Sbjct: 716 ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKK 775
Query: 462 KKGKKDSKKDDKKKDAKKNAESTEMES 488
K + + ++ KK + + +S
Sbjct: 776 PKHSRSRSVEKSQRSGKKASRKHKSKS 802
Score = 72.4 bits (176), Expect = 1e-12
Identities = 84/418 (20%), Positives = 171/418 (40%), Gaps = 61/418 (14%)
Query: 168 ENEQSKKSKSSSETNPESQNSKTVSKNCS----------------QKDKKDSKNSKKTNT 211
E+E+S + SS+T+ E + K + +++K+ ++ K
Sbjct: 397 EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
Query: 212 EFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQN 271
EF+H + N L+ + D ++E + + N +L + + + R+ S +
Sbjct: 457 EFIHKEQNSLSLLEAREADGDVVNE--KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSS 514
Query: 272 NSKNYSLKYTKYT--------------------KKDTKKNAKKSSDAESEDSKDAKKDSK 311
+ + S T T + + K K+ S + S K + S+
Sbjct: 515 SGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSR 574
Query: 312 KVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKD--TKKYPES 369
+ +K + + VK + ++ R++ +++ + + +D T + S
Sbjct: 575 SYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRS 634
Query: 370 TDTESGDAKDARND----SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKD 425
+ D R + S K +K ++KK+ + + D + + + +E ++D++K+
Sbjct: 635 RSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSR-SIDKDRKKKDKEREREQDKRKE 693
Query: 426 K-KDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK---KDAKKNA 481
K K + D K S ++D +SE + S+ G K + DS++D KK KD+KK++
Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESE-RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS 752
Query: 482 ESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIK 539
S + S E GS K+ K A+K S ++S ++G K S K K
Sbjct: 753 GS---------DSSGRSSSESPGSSKE--KKAKKPKHSRSRSVEKSQRSGKKASRKHK 799
Score = 43.1 bits (100), Expect = 8e-04
Identities = 74/389 (19%), Positives = 147/389 (37%), Gaps = 51/389 (13%)
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKD-----TKKNAKKSSDAESEDSKDAKKDSKKVKKNV 317
AW+R + + K K + +KK K + DAE D + SK
Sbjct: 234 AWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEE 293
Query: 318 KKDDKKKDVKKDTESTDAESGDSKDERKD---TKKDKK---------------------- 352
++D + + + T + S ++E D T+++K+
Sbjct: 294 EEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEE 353
Query: 353 --KLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
+ KD +K TK + S A + ++D++ D + TD E
Sbjct: 354 IYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE 413
Query: 411 SELESKESQKDEK--KDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS 468
EL + QK E + +K+ + + K ++ +++ T+ ++ + +++ +
Sbjct: 414 -ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAR 472
Query: 469 KKDDKKKDAKK---NAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFD 525
+ D + KK N ++ +E E K+ +K + + GS + T ST +
Sbjct: 473 EADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS 532
Query: 526 ESSKT----GFKTSTKIKGSDTESEESLYK-PGAKKKIDESDGTSANSKMEGLESK---R 577
SS + +TS++ + S + P K + S S K+E ++ R
Sbjct: 533 SSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR 592
Query: 578 GFRMSSKKTTFNEKGEKASTGRVPPSREK 606
R S++ + E+ S PSRE+
Sbjct: 593 DRRRSNRNSIERERRRNRS-----PSRER 616
Score = 37.4 bits (85), Expect = 0.044
Identities = 72/328 (21%), Positives = 130/328 (39%), Gaps = 49/328 (14%)
Query: 317 VKKDDKKKD-VKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPEST-DTES 374
VK++ + D VK+ T G K ER+ KK +K+ + + + +KK ++T D E
Sbjct: 217 VKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG 276
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAK---KITFS---------TDSESELESKESQ--- 419
GD S+ + D + +A K+T S +D E E KE Q
Sbjct: 277 GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMML 336
Query: 420 -------------KDEK-----KD--KKDSKTDNKKSVKNDEEST-----DADSEPKGDS 454
DE+ KD +K +K K+ ++ ++ GDS
Sbjct: 337 LTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDS 396
Query: 455 KKGKKDEKKGKKDSKKDDKK---KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
+ + D +G + S DD++ + +K E + +L DK+ +EK+ +++ K+
Sbjct: 397 EDERSD--RGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKE 454
Query: 512 -DARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKM 570
+ E E+ + + K + E+ S+ +P + K E G S +
Sbjct: 455 MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNET-TSVLEPKKEHKEKEKQGRSRSGSS 513
Query: 571 EGLESKRGFRMSSKKTTFNEKGEKASTG 598
S R SS +T + +S+G
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSG 541
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 80.9 bits (198), Expect = 3e-15
Identities = 78/387 (20%), Positives = 161/387 (41%), Gaps = 28/387 (7%)
Query: 109 HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYA---TNPESKQIVEEKTKRQNEADKT--PL 163
H K+ E +K + E+ + + K+ S + +V EK + NE P
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
Query: 164 KSSHENEQSKKSKS-SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKK 222
K E E+ +S+S SS + S NS+T S + + S +S + T ++++ K
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTS---SRSSSPK 553
Query: 223 DLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTK 282
KR S P + S + + + ES +R+ ++N +
Sbjct: 554 RKKRHSRSRSPTIKARRSRSRSYSRRIKI-----ESNRARVKIRDRRRSNRNSI------ 602
Query: 283 YTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKD 342
+++ ++N S + S+ + + + ++ +D +K D ++ S ++ +
Sbjct: 603 --ERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660
Query: 343 ERKDTKKDKKK-LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAK 401
+ ++ KK++ + + KD KKKD ++ + E K+ + K S DD+ K +
Sbjct: 661 KEQERKKERSRSIDKDRKKKDKER-----EREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715
Query: 402 KITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDE 461
+ + + K + D ++D K S T + K + S + SE G SK+ K +
Sbjct: 716 ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKK 775
Query: 462 KKGKKDSKKDDKKKDAKKNAESTEMES 488
K + + ++ KK + + +S
Sbjct: 776 PKHSRSRSVEKSQRSGKKASRKHKSKS 802
Score = 72.4 bits (176), Expect = 1e-12
Identities = 84/418 (20%), Positives = 171/418 (40%), Gaps = 61/418 (14%)
Query: 168 ENEQSKKSKSSSETNPESQNSKTVSKNCS----------------QKDKKDSKNSKKTNT 211
E+E+S + SS+T+ E + K + +++K+ ++ K
Sbjct: 397 EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
Query: 212 EFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQN 271
EF+H + N L+ + D ++E + + N +L + + + R+ S +
Sbjct: 457 EFIHKEQNSLSLLEAREADGDVVNE--KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSS 514
Query: 272 NSKNYSLKYTKYT--------------------KKDTKKNAKKSSDAESEDSKDAKKDSK 311
+ + S T T + + K K+ S + S K + S+
Sbjct: 515 SGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSR 574
Query: 312 KVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKD--TKKYPES 369
+ +K + + VK + ++ R++ +++ + + +D T + S
Sbjct: 575 SYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRS 634
Query: 370 TDTESGDAKDARND----SRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKD 425
+ D R + S K +K ++KK+ + + D + + + +E ++D++K+
Sbjct: 635 RSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSR-SIDKDRKKKDKEREREQDKRKE 693
Query: 426 K-KDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK---KDAKKNA 481
K K + D K S ++D +SE + S+ G K + DS++D KK KD+KK++
Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESE-RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS 752
Query: 482 ESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIK 539
S + S E GS K+ K A+K S ++S ++G K S K K
Sbjct: 753 GS---------DSSGRSSSESPGSSKE--KKAKKPKHSRSRSVEKSQRSGKKASRKHK 799
Score = 43.1 bits (100), Expect = 8e-04
Identities = 74/389 (19%), Positives = 147/389 (37%), Gaps = 51/389 (13%)
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKD-----TKKNAKKSSDAESEDSKDAKKDSKKVKKNV 317
AW+R + + K K + +KK K + DAE D + SK
Sbjct: 234 AWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEE 293
Query: 318 KKDDKKKDVKKDTESTDAESGDSKDERKD---TKKDKK---------------------- 352
++D + + + T + S ++E D T+++K+
Sbjct: 294 EEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEE 353
Query: 353 --KLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSE 410
+ KD +K TK + S A + ++D++ D + TD E
Sbjct: 354 IYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE 413
Query: 411 SELESKESQKDEK--KDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS 468
EL + QK E + +K+ + + K ++ +++ T+ ++ + +++ +
Sbjct: 414 -ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAR 472
Query: 469 KKDDKKKDAKK---NAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFD 525
+ D + KK N ++ +E E K+ +K + + GS + T ST +
Sbjct: 473 EADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS 532
Query: 526 ESSKT----GFKTSTKIKGSDTESEESLYK-PGAKKKIDESDGTSANSKMEGLESK---R 577
SS + +TS++ + S + P K + S S K+E ++ R
Sbjct: 533 SSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR 592
Query: 578 GFRMSSKKTTFNEKGEKASTGRVPPSREK 606
R S++ + E+ S PSRE+
Sbjct: 593 DRRRSNRNSIERERRRNRS-----PSRER 616
Score = 37.4 bits (85), Expect = 0.044
Identities = 72/328 (21%), Positives = 130/328 (39%), Gaps = 49/328 (14%)
Query: 317 VKKDDKKKD-VKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPEST-DTES 374
VK++ + D VK+ T G K ER+ KK +K+ + + + +KK ++T D E
Sbjct: 217 VKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG 276
Query: 375 GDAKDARNDSRNLKKASKNDDKKKDAK---KITFS---------TDSESELESKESQ--- 419
GD S+ + D + +A K+T S +D E E KE Q
Sbjct: 277 GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMML 336
Query: 420 -------------KDEK-----KD--KKDSKTDNKKSVKNDEEST-----DADSEPKGDS 454
DE+ KD +K +K K+ ++ ++ GDS
Sbjct: 337 LTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDS 396
Query: 455 KKGKKDEKKGKKDSKKDDKK---KDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
+ + D +G + S DD++ + +K E + +L DK+ +EK+ +++ K+
Sbjct: 397 EDERSD--RGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKE 454
Query: 512 -DARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKM 570
+ E E+ + + K + E+ S+ +P + K E G S +
Sbjct: 455 MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNET-TSVLEPKKEHKEKEKQGRSRSGSS 513
Query: 571 EGLESKRGFRMSSKKTTFNEKGEKASTG 598
S R SS +T + +S+G
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSG 541
>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
sapiens]
Length = 1150
Score = 80.1 bits (196), Expect = 6e-15
Identities = 70/289 (24%), Positives = 138/289 (47%), Gaps = 40/289 (13%)
Query: 281 TKYTKKDTK----KNAKKSSDAESEDSKDAKKD-----SKKVKKNVKKDDKK---KDVKK 328
T ++K D K + +K ++ + SK K +K++K +K+++K K K+
Sbjct: 629 THWSKLDPKTMKVNDLRKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKE 688
Query: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK 388
+ E D +S D K+E + ++++ + ++ +++ P + AK + D +
Sbjct: 689 EDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNWAAKSGKFDCSIMS 748
Query: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKD-------------EKKDKKDSKTDNKK 435
+ D + +D K+ +F +EL ++ Q+D EK+DKK+ +KK
Sbjct: 749 LSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKK 808
Query: 436 SVKND--EESTDADSEPKGDSKKG--KKDEKKGKKDSKKDDKKKDAKKNAESTE------ 485
+ D EE D EPK +K KD+K+ + + KK+DK+KD K+ + TE
Sbjct: 809 DERKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQD 868
Query: 486 ----MESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
ME++ E + ++ E++ +K+D K+D + + ++ E KT
Sbjct: 869 EYDPMEAE-EAEDEEDDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKT 916
Score = 61.6 bits (148), Expect = 2e-09
Identities = 62/297 (20%), Positives = 125/297 (42%), Gaps = 27/297 (9%)
Query: 143 ESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKD 202
ES+ + + K Q A T E ++ +K SE + + + + ++++K
Sbjct: 649 ESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKR 708
Query: 203 SKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFD 262
+ ++ E + + + + CS SL+V + + + S
Sbjct: 709 QEEIERQRRERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVS 768
Query: 263 AWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK 322
+ +++ +++ ++ K +K KK D K +KKD +K KK ++DD+
Sbjct: 769 LFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKD------KKSKKDERKDKKE-ERDDE 821
Query: 323 KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDA-- 380
+ K +SGD KD+++D + KK+ K+ D KD + E + + D +A
Sbjct: 822 TDEPKPKRR----KSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEE 877
Query: 381 ---RNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
D R+ ++ +K DDK+ D + + S KD++K+K T N+
Sbjct: 878 AEDEEDDRDEEEMTKRDDKR----------DINRYCKERPS-KDKEKEKTQMITINR 923
Score = 56.6 bits (135), Expect = 7e-08
Identities = 82/371 (22%), Positives = 147/371 (39%), Gaps = 54/371 (14%)
Query: 103 LYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTP 162
+Y S L + E KK KD+K +KD K++ P+ K + K ++ DK
Sbjct: 786 IYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEPKPK-----RRKSGDDKDKKE 840
Query: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKK 222
+ + E +K S + E N++ ++ +D ++ + E TK + K+
Sbjct: 841 DRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDDR---DEEEMTKRDDKR 897
Query: 223 DLKR---SKTSNDPISEICSENSLNVDFLM-----------LVGQSDDESINFDAWLRNY 268
D+ R + S D E ++N D LM + + D E I + L
Sbjct: 898 DINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLS 957
Query: 269 SQNNSK-------NYSLKYTKYTKKDTKKNAKKSSDAES--ED---------SKDAKKDS 310
K S Y K T DT K+ + ++ES ED + K++S
Sbjct: 958 RAQVKKLLNKVVLRESCFYRKLT--DTSKDEENHEESESLQEDMLGNRLLLPTPTVKQES 1015
Query: 311 KKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKL--KKDDKKKDTKKYPE 368
K V++NV D S + S+ R + ++ + L K D+ +K
Sbjct: 1016 KDVEENVGL-IVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDEKTILNLEN 1074
Query: 369 STDTESGDAKDARNDSRNLK---KASKN------DDKKKDAKKITFSTDSESELESKESQ 419
S + SG+ ++ + D L+ K S+N + K + ++ D + K++
Sbjct: 1075 SNKSLSGELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNV 1134
Query: 420 KDEKKDKKDSK 430
K+E KD+K +
Sbjct: 1135 KNEDKDQKSKE 1145
Score = 55.5 bits (132), Expect = 2e-07
Identities = 38/144 (26%), Positives = 67/144 (46%), Gaps = 26/144 (18%)
Query: 348 KKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFST 407
K+DKK+ K KK + K E D E+ + K R +K+ + DKK+D
Sbjct: 796 KEDKKEKDKKSKKDERKDKKEERDDETDEPKPKR------RKSGDDKDKKED-------- 841
Query: 408 DSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKD 467
E + ++ +KD+ KD +++ DN N +E ++E D + + +E+ K+D
Sbjct: 842 --RDERKKEDKRKDDSKDDDETEEDN-----NQDEYDPMEAEEAEDEEDDRDEEEMTKRD 894
Query: 468 SKKD-----DKKKDAKKNAESTEM 486
K+D ++ K E T+M
Sbjct: 895 DKRDINRYCKERPSKDKEKEKTQM 918
Score = 48.5 bits (114), Expect = 2e-05
Identities = 61/275 (22%), Positives = 115/275 (41%), Gaps = 47/275 (17%)
Query: 318 KKDDKKKDVKKDTESTDAESGDSKDERKDT---KKDKKKLKKDDKKKDTKKYPESTD--- 371
K ++K+ + + + + G++K+ T K D K +K +D +K+ + S+
Sbjct: 600 KLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLRKELESRALSSKGLK 659
Query: 372 -------TESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKK 424
T+ ++ + + + L+K+ K +D+ D K S D + E E K ++ E++
Sbjct: 660 SQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRK----SEDDKEEEERKRQEEIERQ 715
Query: 425 DKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484
++ ++ + DE + P +K GK D D + +D K+++
Sbjct: 716 RRE------RRYILPDEPAIIV--HPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEV 767
Query: 485 EMESDL---ELKKD-----------KKHSKEKKGSKKDIKKDARKD-TESTDAEFDESSK 529
+ ++L L++D ++KK K KKD RKD E D E DE
Sbjct: 768 SLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEP-- 825
Query: 530 TGFKTSTKIKGSDTESEESL--YKPGAKKKIDESD 562
K + G D + +E K K+K D D
Sbjct: 826 ---KPKRRKSGDDKDKKEDRDERKKEDKRKDDSKD 857
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/331 (18%), Positives = 133/331 (40%), Gaps = 25/331 (7%)
Query: 289 KKNAKKSSDAESEDSKDAKKDSKKV--KKNVKKDDKKKDVKKDTESTDAESGDSKDERKD 346
+K A D E +D +AK+ S K K K D++K+ ES S K +
Sbjct: 605 RKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLRKELESRALSSKGLKSQL-- 662
Query: 347 TKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFS 406
+ K+LK +++K++ K+ +S E D D + ++ + ++ ++ ++ +
Sbjct: 663 IARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYI 722
Query: 407 TDSESELE-----SKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKD- 460
E + + +S K + S + + N E S + + ++ ++D
Sbjct: 723 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDF 782
Query: 461 -----EKKGKKDSKKDDKKKDAK-KNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDAR 514
+ K+D K+KD K K E + + + + + D+ K +K KK+ R
Sbjct: 783 GVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKEDR 842
Query: 515 KDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLE 574
+ + D D+S ++ ++ + Y P ++ ++ + +M +
Sbjct: 843 DERKKEDKRKDDSKDD--------DETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRD 894
Query: 575 SKRGFRMSSKKTTFNEKGEKASTGRVPPSRE 605
KR K+ +K EK T + +R+
Sbjct: 895 DKRDINRYCKERPSKDK-EKEKTQMITINRD 924
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/223 (23%), Positives = 109/223 (48%), Gaps = 17/223 (7%)
Query: 314 KKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTE 373
K +++ ++K +++ E E + + +R+ KK+KKK KK ++ K+ ++ + + +
Sbjct: 27 KPCTQRESERKKERREREKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 374 SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDN 433
+ ++ + R KK K ++K+ ++ E E + Q+ E+K KK K
Sbjct: 86 RKERRE--KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 434 KKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELK 493
+K K ++E +G ++ +K KK +++ K++ +K+ KK E E E K
Sbjct: 144 RKERKREKE--------RGKRERKRKKRKKEEREKKRERNRKERKKERERKERR---ERK 192
Query: 494 KDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTST 536
K++K + K KK+ KKD + D ++ F ++ F T
Sbjct: 193 KERKKERRK---KKERKKDRKTDRQTDSQVFRPLRESAFNRVT 232
Score = 76.6 bits (187), Expect = 6e-14
Identities = 51/247 (20%), Positives = 116/247 (46%), Gaps = 42/247 (17%)
Query: 272 NSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTE 331
N++ + + +K T++ +++ + + + +++ ++ ++ KK+ KK+ ++ +
Sbjct: 14 NTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGK 73
Query: 332 STDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKAS 391
+ + + + +RK+ ++ +++ +K +KKK R K+
Sbjct: 74 ERERKRKEREKQRKERREKERRKRKKEKKK-----------------------RERKQRG 110
Query: 392 KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPK 451
+ + KKK +K E E + Q+ E+K KK K +K K ++E +
Sbjct: 111 RRERKKKKERK---------ERERENKQRRERKRKKRRKKKRRKERKREKE--------R 153
Query: 452 GDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
G ++ +K KK +++ K++ +K+ KK E E K+ KK ++KK KKD K
Sbjct: 154 GKRERKRKKRKKEEREKKRERNRKERKKERERKERRE--RKKERKKERRKKKERKKDRKT 211
Query: 512 DARKDTE 518
D + D++
Sbjct: 212 DRQTDSQ 218
Score = 59.3 bits (142), Expect = 1e-08
Identities = 34/177 (19%), Positives = 83/177 (46%), Gaps = 8/177 (4%)
Query: 266 RNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD 325
R + + K + ++ K+ +K + E + + +K+ +K KK KK ++K+
Sbjct: 50 REKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQR 109
Query: 326 VKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSR 385
+++ + ++ ++ ++ +KK +K ++K+ K+ + E G + R +
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR-----EKERGKRERKRKKRK 164
Query: 386 NLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEE 442
++ K + +K+ KK + + E K+ +K E++ KK+ K D K + D +
Sbjct: 165 KEEREKKRERNRKERKK---ERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/221 (21%), Positives = 105/221 (47%), Gaps = 29/221 (13%)
Query: 333 TDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASK 392
T ES + K ER++ +K K++ +K+ K++ KK + K + R ++ K
Sbjct: 30 TQRES-ERKKERREREKRKREREKERKRERGKK----------EKKKRKKRERGKERERK 78
Query: 393 NDDKKKDAKKITFSTDSESELESKESQKDEK-KDKKDSKTDNKKSVKNDEESTDADSEPK 451
+++K K E KE +K +K K K++ K ++ K +E + + E K
Sbjct: 79 RKEREKQRK----------ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128
Query: 452 GDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
++ E+K KK KK ++K+ K+ E + E + +K ++ K+++ ++K+ KK
Sbjct: 129 ------QRRERKRKKRRKK-KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKK 181
Query: 512 DARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKP 552
+ + + + + K K + +D +++ +++P
Sbjct: 182 ERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRP 222
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/198 (18%), Positives = 88/198 (44%), Gaps = 1/198 (0%)
Query: 392 KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPK 451
+++ KK+ ++ + E E + + +K++KK KK + ++ + + E + K
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 452 GDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
K+ K+ +K+ +K + ++KK ++ E + E K+ K+ K+++ +K K+
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 512 DARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKME 571
+++ + + +E K + + K E K KK+ + + K +
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Query: 572 GLESKRGFRMSSKKTTFN 589
+ FR +++ FN
Sbjct: 213 RQTDSQVFR-PLRESAFN 229
Score = 50.4 bits (119), Expect = 5e-06
Identities = 43/200 (21%), Positives = 83/200 (41%), Gaps = 16/200 (8%)
Query: 388 KKASKNDDKKKDAKKITFSTDSESELESK-ESQKDEKKDKKDSKTDNKKSVKNDEESTDA 446
K ++ + ++K ++ E E E K E K EKK +K + ++ K E
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 447 DSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSK 506
+ + +K KK++KK + +K +++ KK E E E + K ++ K KK K
Sbjct: 87 KERREKERRKRKKEKKKRE---RKQRGRRERKKKKERKERERE---NKQRRERKRKKRRK 140
Query: 507 KDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSA 566
K +K+ +++ E E + K K + E + + KK+ + +
Sbjct: 141 KKRRKERKREKERGKRE---------RKRKKRKKEEREKKRERNRKERKKERERKERRER 191
Query: 567 NSKMEGLESKRGFRMSSKKT 586
+ + K+ R +KT
Sbjct: 192 KKERKKERRKKKERKKDRKT 211
Score = 50.1 bits (118), Expect = 7e-06
Identities = 45/220 (20%), Positives = 85/220 (38%), Gaps = 46/220 (20%)
Query: 150 EKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKT 209
EK KR+ E ++ + E ++ KK + E + + + K +K+++ K KK
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Query: 210 NTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYS 269
+ KK +R + +
Sbjct: 104 RERKQRGRRERKKKKERKERERE------------------------------------- 126
Query: 270 QNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKD 329
N + K K KK +K K+ + + K +K KK ++ K++ +K+ KK+
Sbjct: 127 --NKQRRERKRKKRRKKKRRKERKREKERGKRERK--RKKRKKEEREKKRERNRKERKKE 182
Query: 330 TESTDAESGDSKDERKDT---KKDKKKLKKDDKKKDTKKY 366
E E + K ERK KK++KK +K D++ D++ +
Sbjct: 183 RERK--ERRERKKERKKERRKKKERKKDRKTDRQTDSQVF 220
Score = 46.2 bits (108), Expect = 9e-05
Identities = 39/172 (22%), Positives = 73/172 (42%), Gaps = 8/172 (4%)
Query: 430 KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKK-----DSKKDDKKKDAKKNAEST 484
+ +K + + E + E + ++GKK++KK +K ++ +K+ K+ E
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKK-RKKRERGKERERKRKEREKQRKERR 90
Query: 485 EMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
E E K+ KK ++++G ++ KK RK+ E + + E + + + K E
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150
Query: 545 SEESL--YKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEK 594
E K +KK + N K E +R R KK E+ +K
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK 202
Score = 44.3 bits (103), Expect = 4e-04
Identities = 42/189 (22%), Positives = 75/189 (39%), Gaps = 13/189 (6%)
Query: 60 RHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSK 119
R +RK E G+K K + K + +E+ R K K+ + KK +
Sbjct: 50 REKERKRERGKKEKKKRKKRERGKERE-----RKRKEREKQRKERREKERRKRKKEKKKR 104
Query: 120 DEKGG----TPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKS 175
+ K KK+ K++ E K+ K KR+ E + + E ++ K+
Sbjct: 105 ERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRK 164
Query: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
K E E +N K K +K++++ K +K K KKD K + ++ +
Sbjct: 165 KEEREKKRE-RNRKERKKERERKERRERKKERKKER---RKKKERKKDRKTDRQTDSQVF 220
Query: 236 EICSENSLN 244
E++ N
Sbjct: 221 RPLRESAFN 229
Score = 33.1 bits (74), Expect = 0.82
Identities = 30/160 (18%), Positives = 65/160 (40%), Gaps = 7/160 (4%)
Query: 454 SKKGKKDEKKGKKDSKKDDKKK---DAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIK 510
SK + E + KK+ ++ +K+K + ++ E + E K+++ +E+K +++ +
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 511 KDARKDTE----STDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSA 566
+ R++ E + + E + G + K K E+ + K+K
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK 145
Query: 567 NSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
K E KR + +K EK + + RE+
Sbjct: 146 ERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.299 0.119 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,025,732
Number of Sequences: 37866
Number of extensions: 1484594
Number of successful extensions: 39032
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 769
Number of HSP's successfully gapped in prelim test: 1423
Number of HSP's that attempted gapping in prelim test: 10426
Number of HSP's gapped (non-prelim): 12190
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.