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Search of human proteins with 116812624
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116812624 tau tubulin kinase 2 [Homo sapiens]
(1244 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 2498 0.0
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 662 0.0
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 169 2e-41
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 169 2e-41
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 166 1e-40
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 166 1e-40
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 166 1e-40
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 157 6e-38
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 157 8e-38
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 155 3e-37
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 153 1e-36
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 148 4e-35
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 148 4e-35
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 148 4e-35
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 148 4e-35
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 103 8e-22
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 96 2e-19
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 96 2e-19
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 96 2e-19
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 96 2e-19
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 96 2e-19
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 81 5e-15
gi|166295196 checkpoint kinase 1 [Homo sapiens] 74 9e-13
gi|166295194 checkpoint kinase 1 [Homo sapiens] 74 9e-13
gi|166295192 checkpoint kinase 1 [Homo sapiens] 74 9e-13
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 74 1e-12
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 74 1e-12
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 72 4e-12
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 71 6e-12
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 71 7e-12
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 2498 bits (6473), Expect = 0.0
Identities = 1244/1244 (100%), Positives = 1244/1244 (100%)
Query: 1 MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQV 60
MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQV
Sbjct: 1 MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQV 60
Query: 61 LKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
LKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR
Sbjct: 61 LKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPP 180
LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPP
Sbjct: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPP 180
Query: 181 RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKE 240
RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKE
Sbjct: 181 RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKE 240
Query: 241 RYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKT 300
RYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKT
Sbjct: 241 RYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKT 300
Query: 301 GNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIP 360
GNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIP
Sbjct: 301 GNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIP 360
Query: 361 VGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSL 420
VGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSL
Sbjct: 361 VGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSL 420
Query: 421 GSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSA 480
GSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSA
Sbjct: 421 GSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSA 480
Query: 481 GKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNL 540
GKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNL
Sbjct: 481 GKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNL 540
Query: 541 SSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQL 600
SSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQL
Sbjct: 541 SSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQL 600
Query: 601 GPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQA 660
GPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQA
Sbjct: 601 GPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQA 660
Query: 661 EGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGE 720
EGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGE
Sbjct: 661 EGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGE 720
Query: 721 PPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEK 780
PPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEK
Sbjct: 721 PPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEK 780
Query: 781 SILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKN 840
SILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKN
Sbjct: 781 SILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKN 840
Query: 841 NEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFL 900
NEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFL
Sbjct: 841 NEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFL 900
Query: 901 HQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSS 960
HQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSS
Sbjct: 901 HQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSS 960
Query: 961 PVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVL 1020
PVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVL
Sbjct: 961 PVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVL 1020
Query: 1021 TPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPG 1080
TPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPG
Sbjct: 1021 TPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPG 1080
Query: 1081 KPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTP 1140
KPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTP
Sbjct: 1081 KPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTP 1140
Query: 1141 PKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSS 1200
PKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSS
Sbjct: 1141 PKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSS 1200
Query: 1201 RRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR 1244
RRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR
Sbjct: 1201 RRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR 1244
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 662 bits (1709), Expect = 0.0
Identities = 383/716 (53%), Positives = 470/716 (65%), Gaps = 74/716 (10%)
Query: 1 MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQV 60
MSGGGEQ DIL +VK+RWKVL+KIGGGGFGEIY+A+D+LTRENVALKVESAQQPKQV
Sbjct: 14 MSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV 73
Query: 61 LKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
LKMEVAVLKKLQGKDHVCRFIGCGRN++FNYVVMQLQGRNLADLRRSQ RGTFT+STTLR
Sbjct: 74 LKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLR 133
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPP 180
LG+QILESIE+IHSVGFLHRDIKPSNFAMGR PST RKCYMLDFGLARQ+TN+ GDVRPP
Sbjct: 134 LGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPP 193
Query: 181 RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKE 240
R VAGFRGTVRYAS+NAH+NREMGRHDDLWSLFYMLVEF VGQLPWRKIKDKEQVG IKE
Sbjct: 194 RNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 253
Query: 241 RYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKT 300
+Y+HR++LKH+P EF +FLDHI+SLDYFTKPDYQL+ SVF+NS+K G+ E++ FDWEK
Sbjct: 254 KYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKA 313
Query: 301 GNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIP 360
G D +L +T+TST PQ +TR T A G+ N TP+PGDLLRENT++V E LSD EN P
Sbjct: 314 GTD-ALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPP 372
Query: 361 V-------GVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKA-ATEEENSHGQAN 412
+ G+ P P + HP E +VWEE D N+NK+++ I K+ EEE S G
Sbjct: 373 ILPGRPSEGLGPS--PHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCVEEEQSRG--- 427
Query: 413 GLLNAPSLGSPIRVRSEITQPDRDIPLVRKL--RSIHSFELEKRLTLEPKPDTDKFLETC 470
+ PS SP+R PD VR L R ++S E E+ T + + + L
Sbjct: 428 --MGVPS--SPVR-----APPDSPTTPVRSLRYRRVNSPESERLSTADGRVE----LPER 474
Query: 471 LEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGG 530
+M S +++ PA + H D + SA+ ++A
Sbjct: 475 RSRMDLPGSPSRQAC-------SSQPAQMLSVDTGHADRQ--ASGRMDVSASVEQEA--- 522
Query: 531 GSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLE 590
SN F +V L+ +++ DSKEWVI+DKE +L+DF +T +DEEPE L+ L
Sbjct: 523 LSNAFRSVPLAE-EEDFDSKEWVIIDKETELKDFPPG---AEPSTSGTTDEEPEELRPL- 577
Query: 591 ASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAA 650
+E+ +LG AE + S LA E+ L QP
Sbjct: 578 PEEGEERRRLG--AEPTVRPRGRSMQALA-----------EEDLQHLPPQP--------- 615
Query: 651 TPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYS 706
P L +Q +G P P S H G +P +++ P P +++S
Sbjct: 616 LPPQL--SQGDGRSETSQPPTPGSPS----HSPLHSGPRPRRRESDPTGPQRQVFS 665
Score = 73.9 bits (180), Expect = 9e-13
Identities = 82/281 (29%), Positives = 117/281 (41%), Gaps = 24/281 (8%)
Query: 943 SRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKL 1002
SRIPVL E D+ E S +SAKE+ ++ Q DL +L++EKRQ + L S AS
Sbjct: 1054 SRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSS 1113
Query: 1003 LEEK---LATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSW 1059
EE+ T+ EE+ + R+A + +S+IPRP+
Sbjct: 1114 SEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAA-----------ATRSRIPRPIGL 1162
Query: 1060 VNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGS 1119
V + Q R P + +RL+ GS+ + +DL R Q G
Sbjct: 1163 RMPMPV---AAQQPASRSHGAAPALDTAITSRLQLQTPPGSATA-ADL--RPKQPPGRGL 1216
Query: 1120 QKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPH-HDQ 1178
R+ + P +P +P+ P + R+ SASPRS SL R S SPS RP
Sbjct: 1217 GPGRAQAGARPP-APRSPRLPASTSAA--RNASASPRSQSLSRRESPSPSHQARPGVPPP 1273
Query: 1179 RSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGS 1219
R P + PS GS R Q +K G+
Sbjct: 1274 RGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGA 1314
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 169 bits (428), Expect = 2e-41
Identities = 106/288 (36%), Positives = 149/288 (51%), Gaps = 9/288 (3%)
Query: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76
V R+++ RKIG G FG+IY D+ E VA+K+E + L +E + K +QG
Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVG 64
Query: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVG 136
+ CG +N +VM+L G +L DL SR F++ T L L Q++ IE IHS
Sbjct: 65 IPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR-KFSLKTVLLLADQMISRIEYIHSKN 123
Query: 137 FLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVR-PPRAVAGFRGTVRYASI 195
F+HRD+KP NF MG Y++DFGLA+++ ++ P R GT RYASI
Sbjct: 124 FIHRDVKPDNFLMG-LGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182
Query: 196 NAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLMLK 249
N H E R DDL SL Y+L+ F +G LPW+ +K E++ K ++ K
Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCK 242
Query: 250 HLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
P EF+ +L+ SL + KPDY L +F N G FDW
Sbjct: 243 GYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW 290
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 169 bits (428), Expect = 2e-41
Identities = 106/288 (36%), Positives = 149/288 (51%), Gaps = 9/288 (3%)
Query: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76
V R+++ RKIG G FG+IY D+ E VA+K+E + L +E + K +QG
Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVG 64
Query: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVG 136
+ CG +N +VM+L G +L DL SR F++ T L L Q++ IE IHS
Sbjct: 65 IPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR-KFSLKTVLLLADQMISRIEYIHSKN 123
Query: 137 FLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVR-PPRAVAGFRGTVRYASI 195
F+HRD+KP NF MG Y++DFGLA+++ ++ P R GT RYASI
Sbjct: 124 FIHRDVKPDNFLMG-LGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182
Query: 196 NAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLMLK 249
N H E R DDL SL Y+L+ F +G LPW+ +K E++ K ++ K
Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCK 242
Query: 250 HLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
P EF+ +L+ SL + KPDY L +F N G FDW
Sbjct: 243 GYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW 290
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 166 bits (420), Expect = 1e-40
Identities = 105/289 (36%), Positives = 152/289 (52%), Gaps = 9/289 (3%)
Query: 16 LVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD 75
+V ++K++RKIG G FG+IY A+++ E VA+K+ES + L E + K LQG
Sbjct: 12 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71
Query: 76 HVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSV 135
+ G+ +N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHTK 130
Query: 136 GFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQF-TNSCGDVRPPRAVAGFRGTVRYAS 194
F+HRDIKP NF MG C K +++DFGLA+++ N P R GT RYAS
Sbjct: 131 NFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
Query: 195 INAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLML 248
INAH E R DD+ SL Y+L+ F LPW+ +K E++ K ++
Sbjct: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
Query: 249 KHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
K P EF+++L++ L + PDY L +F +T FDW
Sbjct: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 166 bits (420), Expect = 1e-40
Identities = 105/288 (36%), Positives = 149/288 (51%), Gaps = 9/288 (3%)
Query: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76
V ++++ RKIG G FG+IY ++ + E VA+K+E + L +E K +QG
Sbjct: 5 VGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVG 64
Query: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVG 136
+ CG +N +VM+L G +L DL SR F++ T L L Q++ IE IHS
Sbjct: 65 IPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSR-KFSLKTVLLLADQMISRIEYIHSKN 123
Query: 137 FLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVR-PPRAVAGFRGTVRYASI 195
F+HRD+KP NF MG Y++DFGLA+++ ++ P R GT RYASI
Sbjct: 124 FIHRDVKPDNFLMG-LGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182
Query: 196 NAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLMLK 249
N H E R DDL SL Y+L+ F +G LPW+ +K E++ K ++ K
Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCK 242
Query: 250 HLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
P EFS +L+ SL + KPDY L +F N G FDW
Sbjct: 243 GYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW 290
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 166 bits (420), Expect = 1e-40
Identities = 105/288 (36%), Positives = 149/288 (51%), Gaps = 9/288 (3%)
Query: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76
V ++++ RKIG G FG+IY ++ + E VA+K+E + L +E K +QG
Sbjct: 5 VGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVG 64
Query: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVG 136
+ CG +N +VM+L G +L DL SR F++ T L L Q++ IE IHS
Sbjct: 65 IPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSR-KFSLKTVLLLADQMISRIEYIHSKN 123
Query: 137 FLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVR-PPRAVAGFRGTVRYASI 195
F+HRD+KP NF MG Y++DFGLA+++ ++ P R GT RYASI
Sbjct: 124 FIHRDVKPDNFLMG-LGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182
Query: 196 NAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLMLK 249
N H E R DDL SL Y+L+ F +G LPW+ +K E++ K ++ K
Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCK 242
Query: 250 HLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
P EFS +L+ SL + KPDY L +F N G FDW
Sbjct: 243 GYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW 290
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 157 bits (397), Expect = 6e-38
Identities = 99/320 (30%), Positives = 165/320 (51%), Gaps = 13/320 (4%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++V +KIG G FGE+ ++ T E VA+K+E + L +E K+L
Sbjct: 40 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSAT 99
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
+ V + G ++N +V++L G +L DL R TFT+ T L + Q++ +E +H+
Sbjct: 100 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLITRMEYVHT 158
Query: 135 VGFLHRDIKPSNFAMGRFPSTCRK--CYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVR 191
++RD+KP NF +GR P T R+ +++DFGLA+++ + P R GT R
Sbjct: 159 KSLIYRDVKPENFLVGR-PGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 217
Query: 192 YASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHR 245
Y SIN H +E R DDL +L +M + F+ G LPW+ +K +++G K
Sbjct: 218 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 277
Query: 246 LMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGS 305
++ ++ P E + +L ++ LD+F KPDY L +F + G + +DW
Sbjct: 278 VLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTP 337
Query: 306 LTTTTTS--TTPQLHTRLTP 323
+ T T + PQL + P
Sbjct: 338 IGTVHTDLPSQPQLRDKTQP 357
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 157 bits (396), Expect = 8e-38
Identities = 103/290 (35%), Positives = 148/290 (51%), Gaps = 9/290 (3%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++K++RKIG G FG++Y + E VA+K+ES + L E + LQG
Sbjct: 11 LVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQGG 70
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
+ G+ N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 71 VGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHT 129
Query: 135 VGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQF-TNSCGDVRPPRAVAGFRGTVRYA 193
FLHRDIKP NF MG C K +++DFGLA+++ N P R GTVRYA
Sbjct: 130 KNFLHRDIKPDNFLMGT-GRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYA 188
Query: 194 SINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLM 247
SINAH E R DD+ SL Y+ + F LPW+ +K E++ K ++
Sbjct: 189 SINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVL 248
Query: 248 LKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
K P EF+++L++ L + PDY L +F +T FDW
Sbjct: 249 CKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDW 298
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 155 bits (391), Expect = 3e-37
Identities = 106/317 (33%), Positives = 153/317 (48%), Gaps = 37/317 (11%)
Query: 16 LVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD 75
+V ++K++RKIG G FG+IY A+++ E VA+K+ES + L E + K LQG
Sbjct: 12 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71
Query: 76 HVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSV 135
+ G+ +N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHTK 130
Query: 136 GFLHRDIKPSNFAMGRFPSTCRKC----------------------------YMLDFGLA 167
F+HRDIKP NF MG C KC +++DFGLA
Sbjct: 131 NFIHRDIKPDNFLMG-IGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
Query: 168 RQFT-NSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW 226
+++ N P R GT RYASINAH E R DD+ SL Y+L+ F LPW
Sbjct: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
Query: 227 RKIK------DKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVF 280
+ +K E++ K ++ K P EF+++L++ L + PDY L +F
Sbjct: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
Query: 281 DNSIKTFGVIESDPFDW 297
+T FDW
Sbjct: 310 RILFRTLNHQYDYTFDW 326
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 153 bits (386), Expect = 1e-36
Identities = 99/308 (32%), Positives = 159/308 (51%), Gaps = 20/308 (6%)
Query: 2 SGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVL 61
SG +L VG ++V +KIG G FGE+ ++ T E VA+K+E + L
Sbjct: 29 SGSSSSSGVLMVG----PNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQL 84
Query: 62 KMEVAVLKKL----QGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTIST 117
+E K+L +G V F CG+ +N +V++L G +L DL R TFT+ T
Sbjct: 85 HLEYRFYKQLGSAGEGLPQVYYFGPCGK---YNAMVLELLGPSLEDLFDLCDR-TFTLKT 140
Query: 118 TLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKC-YMLDFGLARQFTNSCGD 176
L + Q+L +E +HS ++RD+KP NF +GR + +++DFGLA+++ +
Sbjct: 141 VLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETK 200
Query: 177 VRPP-RAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK--- 232
P R GT RY SIN H +E R DDL +L +M + F+ G LPW+ +K
Sbjct: 201 KHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLK 260
Query: 233 ---EQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGV 289
+++G K + ++ P E + +L ++ LD+F KPDY+ L ++F + + G
Sbjct: 261 ERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGY 320
Query: 290 IESDPFDW 297
+DW
Sbjct: 321 TFDYAYDW 328
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 148 bits (373), Expect = 4e-35
Identities = 91/291 (31%), Positives = 155/291 (53%), Gaps = 10/291 (3%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++V +KIG G FGE+ ++ T E VA+K+E + L +E K+L
Sbjct: 37 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
D + + G ++N +V++L G +L DL R TF++ T L + Q++ +E +HS
Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHS 155
Query: 135 VGFLHRDIKPSNFAMGRFPS-TCRKCYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVRY 192
++RD+KP NF +GR + T + +++DFGLA+++ + P R GT RY
Sbjct: 156 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 215
Query: 193 ASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRL 246
SIN H +E R DDL +L +M + F+ G LPW+ +K +++G K +
Sbjct: 216 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 275
Query: 247 MLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
+ ++ PE + +L ++ LD+F KPDY L +F + G + +DW
Sbjct: 276 LCENF-PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 148 bits (373), Expect = 4e-35
Identities = 91/291 (31%), Positives = 155/291 (53%), Gaps = 10/291 (3%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++V +KIG G FGE+ ++ T E VA+K+E + L +E K+L
Sbjct: 37 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
D + + G ++N +V++L G +L DL R TF++ T L + Q++ +E +HS
Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHS 155
Query: 135 VGFLHRDIKPSNFAMGRFPS-TCRKCYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVRY 192
++RD+KP NF +GR + T + +++DFGLA+++ + P R GT RY
Sbjct: 156 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 215
Query: 193 ASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRL 246
SIN H +E R DDL +L +M + F+ G LPW+ +K +++G K +
Sbjct: 216 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 275
Query: 247 MLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
+ ++ PE + +L ++ LD+F KPDY L +F + G + +DW
Sbjct: 276 LCENF-PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 148 bits (373), Expect = 4e-35
Identities = 91/291 (31%), Positives = 155/291 (53%), Gaps = 10/291 (3%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++V +KIG G FGE+ ++ T E VA+K+E + L +E K+L
Sbjct: 37 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
D + + G ++N +V++L G +L DL R TF++ T L + Q++ +E +HS
Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHS 155
Query: 135 VGFLHRDIKPSNFAMGRFPS-TCRKCYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVRY 192
++RD+KP NF +GR + T + +++DFGLA+++ + P R GT RY
Sbjct: 156 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 215
Query: 193 ASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRL 246
SIN H +E R DDL +L +M + F+ G LPW+ +K +++G K +
Sbjct: 216 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 275
Query: 247 MLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
+ ++ PE + +L ++ LD+F KPDY L +F + G + +DW
Sbjct: 276 LCENF-PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 148 bits (373), Expect = 4e-35
Identities = 91/291 (31%), Positives = 155/291 (53%), Gaps = 10/291 (3%)
Query: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
++V ++V +KIG G FGE+ ++ T E VA+K+E + L +E K+L
Sbjct: 37 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
Query: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
D + + G ++N +V++L G +L DL R TF++ T L + Q++ +E +HS
Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHS 155
Query: 135 VGFLHRDIKPSNFAMGRFPS-TCRKCYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVRY 192
++RD+KP NF +GR + T + +++DFGLA+++ + P R GT RY
Sbjct: 156 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 215
Query: 193 ASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRL 246
SIN H +E R DDL +L +M + F+ G LPW+ +K +++G K +
Sbjct: 216 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 275
Query: 247 MLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
+ ++ PE + +L ++ LD+F KPDY L +F + G + +DW
Sbjct: 276 LCENF-PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 103 bits (258), Expect = 8e-22
Identities = 94/334 (28%), Positives = 150/334 (44%), Gaps = 48/334 (14%)
Query: 16 LVKERWKVLRKIGGGGFGEIYDALDMLTRENVA------LKVES---------------A 54
+ K+ WKV IG GGFG IY A DM + E+V +KVE A
Sbjct: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90
Query: 55 QQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDR----FNYVVMQLQGRNLADLRRSQSR 110
+P+Q+ K K G V ++ G G +D+ + +++M G +L + + ++
Sbjct: 91 AKPEQIQKWIRTRKLKYLG---VPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147
Query: 111 GTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQF 170
F+ T L+L +IL+ +E IH ++H DIK SN + + Y++D+GLA ++
Sbjct: 148 -RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY--KNPDQVYLVDYGLAYRY 204
Query: 171 ----TNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW 226
+ P R GT+ + SI+AH R DL L Y +++++ G LPW
Sbjct: 205 CPEGVHKEYKEDPKRC---HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261
Query: 227 R-KIKDKEQVGSIKERY--------DHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLT 277
+KD + V K RY D K+ P E + +++ + LDY KP Y+ L
Sbjct: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321
Query: 278 SVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTT 311
+ +K G + D N G T T
Sbjct: 322 DILLQGLKAIGSKDDGKLDLSVVENGGLKAKTIT 355
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 95.9 bits (237), Expect = 2e-19
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
Query: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 88 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
Query: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
Query: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 95.9 bits (237), Expect = 2e-19
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 5 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 64
Query: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 65 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 122
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 123 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 180
Query: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 181 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 240
Query: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 241 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 291
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 95.9 bits (237), Expect = 2e-19
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
Query: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 88 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
Query: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
Query: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 95.9 bits (237), Expect = 2e-19
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
Query: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 88 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
Query: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
Query: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 95.9 bits (237), Expect = 2e-19
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
Query: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 88 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
Query: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
Query: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
Query: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 81.3 bits (199), Expect = 5e-15
Identities = 62/200 (31%), Positives = 99/200 (49%), Gaps = 14/200 (7%)
Query: 92 VVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGR 151
+VM+ G +L + S GTF ST L+LG ++L+ +E IH ++H DIK +N +G
Sbjct: 1 MVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
Query: 152 FPSTCRKCYMLDFGLA-RQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLW 210
+ Y+ D+GL+ R N G GT+ + S++AH+ + R D+
Sbjct: 59 --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
Query: 211 SLFYMLVEFVVGQLPW-RKIKDKEQVGSIKERYDHRL---MLKHLPP-----EFSIFLDH 261
L Y ++ ++ G+LPW + +KD V + K L +LK P E + FL
Sbjct: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVC 176
Query: 262 ISSLDYFTKPDYQLLTSVFD 281
SL Y KP+YQ L + +
Sbjct: 177 AHSLAYDEKPNYQALKKILN 196
>gi|166295196 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 73.9 bits (180), Expect = 9e-13
Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 16/221 (7%)
Query: 19 ERWKVLRKIGGGGFGEIYDALDMLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 75
E W +++ +G G +GE+ A++ +T E VA+K+ + A + +K E+ + K+ +
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHE 65
Query: 76 HVCRFIGCGRNDRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
+V +F G R Y+ ++ G L D R + R Q++ + +H
Sbjct: 66 NVVKFYGHRREGNIQYLFLEYCSGGELFD--RIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123
Query: 135 VGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYAS 194
+G HRDIKP N + + + DFGLA F + R + GT+ Y +
Sbjct: 124 IGITHRDIKPENLLLDERDN----LKISDFGLATVFRYN----NRERLLNKMCGTLPYVA 175
Query: 195 INAHRNREMGRHD-DLWSLFYMLVEFVVGQLPWRKIKDKEQ 234
+ RE D+WS +L + G+LPW + D Q
Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ 216
>gi|166295194 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 73.9 bits (180), Expect = 9e-13
Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 16/221 (7%)
Query: 19 ERWKVLRKIGGGGFGEIYDALDMLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 75
E W +++ +G G +GE+ A++ +T E VA+K+ + A + +K E+ + K+ +
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHE 65
Query: 76 HVCRFIGCGRNDRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
+V +F G R Y+ ++ G L D R + R Q++ + +H
Sbjct: 66 NVVKFYGHRREGNIQYLFLEYCSGGELFD--RIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123
Query: 135 VGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYAS 194
+G HRDIKP N + + + DFGLA F + R + GT+ Y +
Sbjct: 124 IGITHRDIKPENLLLDERDN----LKISDFGLATVFRYN----NRERLLNKMCGTLPYVA 175
Query: 195 INAHRNREMGRHD-DLWSLFYMLVEFVVGQLPWRKIKDKEQ 234
+ RE D+WS +L + G+LPW + D Q
Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ 216
>gi|166295192 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 73.9 bits (180), Expect = 9e-13
Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 16/221 (7%)
Query: 19 ERWKVLRKIGGGGFGEIYDALDMLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 75
E W +++ +G G +GE+ A++ +T E VA+K+ + A + +K E+ + K+ +
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHE 65
Query: 76 HVCRFIGCGRNDRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
+V +F G R Y+ ++ G L D R + R Q++ + +H
Sbjct: 66 NVVKFYGHRREGNIQYLFLEYCSGGELFD--RIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123
Query: 135 VGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYAS 194
+G HRDIKP N + + + DFGLA F + R + GT+ Y +
Sbjct: 124 IGITHRDIKPENLLLDERDN----LKISDFGLATVFRYN----NRERLLNKMCGTLPYVA 175
Query: 195 INAHRNREMGRHD-DLWSLFYMLVEFVVGQLPWRKIKDKEQ 234
+ RE D+WS +L + G+LPW + D Q
Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ 216
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/252 (26%), Positives = 116/252 (46%), Gaps = 20/252 (7%)
Query: 21 WKVLRKIGGGGFGEIYDALDMLTRENVALKV-----ESAQQPKQV--LKMEVAVLKKLQG 73
W+ + +G G FG +Y D+ T +A K +S + K+V L+ E+ +LK LQ
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ- 451
Query: 74 KDHVCRFIGCGRN--DRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIE 130
+ + ++ GC R+ ++ + M+ + G ++ D + ++ G T S T + RQILE +
Sbjct: 452 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKD--QLKAYGALTESVTRKYTRQILEGMS 509
Query: 131 SIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTV 190
+HS +HRDIK +N + + DFG +++ C R+V GT
Sbjct: 510 YLHSNMIVHRDIKGANI----LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVT---GTP 562
Query: 191 RYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKH 250
+ S GR D+WSL +VE + + PW + + + I + + + H
Sbjct: 563 YWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH 622
Query: 251 LPPEFSIFLDHI 262
+ FL I
Sbjct: 623 ISEHGRDFLRRI 634
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/252 (26%), Positives = 116/252 (46%), Gaps = 20/252 (7%)
Query: 21 WKVLRKIGGGGFGEIYDALDMLTRENVALKV-----ESAQQPKQV--LKMEVAVLKKLQG 73
W+ + +G G FG +Y D+ T +A K +S + K+V L+ E+ +LK LQ
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ- 420
Query: 74 KDHVCRFIGCGRN--DRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIE 130
+ + ++ GC R+ ++ + M+ + G ++ D + ++ G T S T + RQILE +
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKD--QLKAYGALTESVTRKYTRQILEGMS 478
Query: 131 SIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTV 190
+HS +HRDIK +N + + DFG +++ C R+V GT
Sbjct: 479 YLHSNMIVHRDIKGANI----LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVT---GTP 531
Query: 191 RYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKH 250
+ S GR D+WSL +VE + + PW + + + I + + + H
Sbjct: 532 YWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH 591
Query: 251 LPPEFSIFLDHI 262
+ FL I
Sbjct: 592 ISEHGRDFLRRI 603
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 71.6 bits (174), Expect = 4e-12
Identities = 61/252 (24%), Positives = 115/252 (45%), Gaps = 20/252 (7%)
Query: 21 WKVLRKIGGGGFGEIYDALDMLTRENVALKV-----ESAQQPKQV--LKMEVAVLKKLQG 73
W++ + +G G FG +Y D+ T +A+K +S + K+V L+ E+ +LK L
Sbjct: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL- 414
Query: 74 KDHVCRFIGCGRNDR---FNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIE 130
+ + ++ GC R+ + + + + G ++ D + ++ G T + T + RQILE +
Sbjct: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKD--QLKAYGALTENVTRKYTRQILEGVH 472
Query: 131 SIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTV 190
+HS +HRDIK +N + + DFG +++ C ++V GT
Sbjct: 473 YLHSNMIVHRDIKGANI----LRDSTGNVKLGDFGASKRLQTICLSGTGMKSVT---GTP 525
Query: 191 RYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKH 250
+ S GR D+WS+ +VE + + PW + + + I + + + H
Sbjct: 526 YWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH 585
Query: 251 LPPEFSIFLDHI 262
+ FL I
Sbjct: 586 VSDYTRDFLKRI 597
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 71.2 bits (173), Expect = 6e-12
Identities = 59/212 (27%), Positives = 103/212 (48%), Gaps = 18/212 (8%)
Query: 18 KERWKVLRKIGGGGFGEIYDALDMLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGK 74
+E + L +IG G FGE++ +D T++ VA+K+ E A+ + ++ E+ VL +
Sbjct: 21 EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD-S 79
Query: 75 DHVCRFIGCGRNDRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIH 133
+V ++ G +++M+ L G + DL R+ F I+T L ++IL+ ++ +H
Sbjct: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATML---KEILKGLDYLH 136
Query: 134 SVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYA 193
S +HRDIK +N + S + DFG+A Q T D + R F GT +
Sbjct: 137 SEKKIHRDIKAANVLL----SEQGDVKLADFGVAGQLT----DTQIKRNT--FVGTPFWM 186
Query: 194 SINAHRNREMGRHDDLWSLFYMLVEFVVGQLP 225
+ + D+WSL +E G+ P
Sbjct: 187 APEVIQQSAYDSKADIWSLGITAIELAKGEPP 218
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 70.9 bits (172), Expect = 7e-12
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 18/212 (8%)
Query: 18 KERWKVLRKIGGGGFGEIYDALDMLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGK 74
+E + L KIG G FGE++ +D T++ VA+K+ E A+ + ++ E+ VL +
Sbjct: 21 EELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD-S 79
Query: 75 DHVCRFIGCGRNDRFNYVVMQ-LQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIH 133
+V ++ G D +++M+ L G + DL I+T L R+IL+ ++ +H
Sbjct: 80 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATIL---REILKGLDYLH 136
Query: 134 SVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYA 193
S +HRDIK +N + S + + DFG+A Q T D + R F GT +
Sbjct: 137 SEKKIHRDIKAANVLL----SEHGEVKLADFGVAGQLT----DTQIKRNT--FVGTPFWM 186
Query: 194 SINAHRNREMGRHDDLWSLFYMLVEFVVGQLP 225
+ + D+WSL +E G+ P
Sbjct: 187 APEVIKQSAYDSKADIWSLGITAIELARGEPP 218
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,372,880
Number of Sequences: 37866
Number of extensions: 2859499
Number of successful extensions: 16713
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 1018
Number of HSP's that attempted gapping in prelim test: 12397
Number of HSP's gapped (non-prelim): 4087
length of query: 1244
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1130
effective length of database: 13,930,794
effective search space: 15741797220
effective search space used: 15741797220
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.