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Search of human proteins with 116805327
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
precursor [Homo sapiens]
(725 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) pr... 1437 0.0
gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide... 473 e-133
gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide ... 469 e-132
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 236 6e-62
gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo ... 236 6e-62
gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo ... 236 6e-62
gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 236 6e-62
gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo ... 236 6e-62
gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens] 235 9e-62
gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo sa... 62 1e-09
gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precurso... 62 1e-09
gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor... 62 1e-09
gi|18105007 carbamoylphosphate synthetase 2/aspartate transcarba... 55 2e-07
gi|110671329 dihydrolipoamide branched chain transacylase precur... 40 0.006
gi|164663810 ribosomal modification protein rimK-like family mem... 36 0.14
gi|134254462 ribosomal modification protein rimK-like family mem... 35 0.32
gi|203098816 pyruvate dehydrogenase complex, component X isoform... 34 0.55
gi|203098753 pyruvate dehydrogenase complex, component X isoform... 34 0.55
gi|28416899 phosphoribosylglycinamide formyltransferase, phospho... 33 0.93
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 33 0.93
gi|209869995 phosphoribosylglycinamide formyltransferase, phosph... 33 0.93
gi|209869993 phosphoribosylglycinamide formyltransferase, phosph... 33 0.93
gi|110349719 titin isoform N2-A [Homo sapiens] 32 1.6
gi|110349717 titin isoform novex-2 [Homo sapiens] 32 1.6
gi|110349713 titin isoform novex-1 [Homo sapiens] 32 1.6
gi|110349715 titin isoform N2-B [Homo sapiens] 32 1.6
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 31 3.5
>gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
precursor [Homo sapiens]
Length = 725
Score = 1437 bits (3721), Expect = 0.0
Identities = 725/725 (100%), Positives = 725/725 (100%)
Query: 1 MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEI 60
MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEI
Sbjct: 1 MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEI 60
Query: 61 ACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTS 120
ACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTS
Sbjct: 61 ACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTS 120
Query: 121 AAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEG 180
AAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEG
Sbjct: 121 AAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEG 180
Query: 181 YHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
YHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN
Sbjct: 181 YHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK
Sbjct: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL
Sbjct: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
Query: 361 RIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGV 420
RIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGV
Sbjct: 361 RIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGV 420
Query: 421 RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFE 480
RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFE
Sbjct: 421 RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFE 480
Query: 481 AGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSS 540
AGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSS
Sbjct: 481 AGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSS 540
Query: 541 SGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKC 600
SGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKC
Sbjct: 541 SGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKC 600
Query: 601 SVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKV 660
SVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKV
Sbjct: 601 SVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKV 660
Query: 661 FVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESD 720
FVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESD
Sbjct: 661 FVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESD 720
Query: 721 KRESE 725
KRESE
Sbjct: 721 KRESE 725
>gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform b [Homo sapiens]
Length = 702
Score = 473 bits (1217), Expect = e-133
Identities = 285/724 (39%), Positives = 415/724 (57%), Gaps = 50/724 (6%)
Query: 10 LLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEIACRVMRTAK 69
L+ A R RW PP+ Q + T + K+L+ANRGEIACRV+RT K
Sbjct: 11 LVAAGRRGRW--------PPQ-----QLMLSAALRTLKTFDKILVANRGEIACRVIRTCK 57
Query: 70 KLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGC 129
K+G++TVA++S+ D +S+HV MADEA +GPAP+ +SYL+M+ I++ K + AQA+HPG
Sbjct: 58 KMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGY 117
Query: 130 GFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQ 189
GFLSEN EFA E ++FIGP AI+ MG K SK + A V + G+ G + +
Sbjct: 118 GFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAE 177
Query: 190 CLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKF 249
AR IGYPVMIKA GGGGKGMRI ++E ++ + +EA SF DD +LIEKF
Sbjct: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
Query: 250 VDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRA 309
+D PRH+E+QV GD HGNA++L ER+CS+QRR+QK++EEAP+ + +E R+ +GE AV
Sbjct: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
Query: 310 AKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
A+AV Y AGTVEF++DSK NF F+EMNTRLQVEHPVTE ITG DLV+ +R+A G +
Sbjct: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
Query: 370 LSQEEITLQGHAFEARIYAEDPSNNF-MPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV 428
Q +I + G A E R+YAEDP +F +P G L P P R+++G++ G ++S+
Sbjct: 358 HKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISI 417
Query: 429 HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDF 488
+YDPMI+KL+ + +DR AL ++ +L Y I G+ NI L + + F G++ T F
Sbjct: 418 YYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKF 477
Query: 489 I----PQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRR 544
+ P K +L++ + K L A L + F L+A F S +
Sbjct: 478 LSDVYPDGFKGHMLTK--SEKNQLLAIASSLFV-------AFQLRA-QHFQENSRMPVIK 527
Query: 545 LNI-SYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLG--NLYSEGDCTYLKCS 601
+I ++ ++ L D V V N+ +S++++ V NL S L S
Sbjct: 528 PDIANWELSVKLHD---KVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS----PLLSVS 580
Query: 602 VNGVASKAKLIILE----------NTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLA 651
V+G + + E T+Y + + ++ K++ +++T +
Sbjct: 581 VDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAEL--NKFMLEKVTEDTSSVLRS 638
Query: 652 PMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPL 711
PM G + V VK GD V G + V+ AMKM++++ + K GTVK V + G L
Sbjct: 639 PMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLL 698
Query: 712 VEFE 715
VE E
Sbjct: 699 VELE 702
>gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform a precursor [Homo sapiens]
Length = 728
Score = 469 bits (1206), Expect = e-132
Identities = 276/687 (40%), Positives = 403/687 (58%), Gaps = 37/687 (5%)
Query: 47 RNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQS 106
+ K+L+ANRGEIACRV+RT KK+G++TVA++S+ D +S+HV MADEA +GPAP+ +S
Sbjct: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
Query: 107 YLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTS 166
YL+M+ I++ K + AQA+HPG GFLSEN EFA E ++FIGP AI+ MG K S
Sbjct: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
Query: 167 KSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQE 226
K + A V + G+ G + + AR IGYPVMIKA GGGGKGMRI ++E ++
Sbjct: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
Query: 227 QLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII 286
+ +EA SF DD +LIEKF+D PRH+E+QV GD HGNA++L ER+CS+QRR+QK++
Sbjct: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
Query: 287 EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPV 346
EEAP+ + +E R+ +GE AV A+AV Y AGTVEF++DSK NF F+EMNTRLQVEHPV
Sbjct: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
Query: 347 TEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNF-MPVAGPLVHL 405
TE ITG DLV+ +R+A G + Q +I + G A E R+YAEDP +F +P G L
Sbjct: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
Query: 406 STPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHT 465
P P R+++G++ G ++S++YDPMI+KL+ + +DR AL ++ +L Y I G+
Sbjct: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
Query: 466 NIDFLLNLSGHPEFEAGNVHTDFI----PQHHKQLLLSRKAAAKESLCQAALGLILKEKA 521
NI L + + F G++ T F+ P K +L++ + K L A L +
Sbjct: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTK--SEKNQLLAIASSLFV---- 534
Query: 522 MTDTFTLQAHDQFSPFSSSSGRRLNI-SYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIED 580
F L+A F S + +I ++ ++ L D V V N+ +S++++
Sbjct: 535 ---AFQLRA-QHFQENSRMPVIKPDIANWELSVKLHD---KVHTVVASNNGSVFSVEVDG 587
Query: 581 KTFQVLG--NLYSEGDCTYLKCSVNGVASKAKLIILE----------NTIYLFSKEGSIE 628
V NL S L SV+G + + E T+Y + +
Sbjct: 588 SKLNVTSTWNLAS----PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
Query: 629 IDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKS 688
++ K++ +++T +PM G + V VK GD V G + V+ AMKM++++ +
Sbjct: 644 AEL--NKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTA 701
Query: 689 PKDGTVKKVFYREGAQANRHTPLVEFE 715
K GTVK V + G LVE E
Sbjct: 702 GKTGTVKSVHCQAGDTVGEGDLLVELE 728
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (967), Expect = e-104
Identities = 214/540 (39%), Positives = 308/540 (57%), Gaps = 9/540 (1%)
Query: 49 ITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQ-QSY 107
I KV++ANRGEIA RV R +LG++TVA+YSE D MH ADEAY IG + Q+Y
Sbjct: 37 IKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAY 96
Query: 108 LSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSK 167
L + II+VAK + A+HPG GFLSE +FA+ C+ G+ FIGP P +R MG K ++
Sbjct: 97 LHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEAR 156
Query: 168 SIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQ 227
+I AAGVPVV G S E + G+P++ KA GGGG+GMR+V S +E +E
Sbjct: 157 AIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEEN 216
Query: 228 LESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIE 287
A EA +F + A+ +EKF++ PRH+EVQ+ GD +GN ++L+ERDCS+QRRHQK++E
Sbjct: 217 YTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVE 276
Query: 288 EAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVT 347
APA + ++R +L +V+ AK V Y AGTVEF++D F+E+N+RLQVEH VT
Sbjct: 277 IAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVT 336
Query: 348 EMITGTDLVEWQLRIAAGEKIP---LSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVH 404
E IT DLV Q+ +A G +P L QE I + G A + R+ EDP+ +F P G +
Sbjct: 337 EEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEV 396
Query: 405 LSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLH 464
+ QG +S HYD ++ K++ D A TK+ +L ++ + G+
Sbjct: 397 FRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVK 456
Query: 465 TNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTD 524
TNI FL N+ + +F AG V T FI + + +L R A + LG ++ T
Sbjct: 457 TNIAFLQNVLNNQQFLAGTVDTQFIDE-NPELFQLRPAQNRAQKLLHYLGHVMVNGPTTP 515
Query: 525 TFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQ 584
+ P + + R++ L++G A AV NH G + + D TF+
Sbjct: 516 IPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVR-NHPG---LLLMDTTFR 571
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/64 (45%), Positives = 35/64 (54%), Gaps = 5/64 (7%)
Query: 634 PKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGT 693
PK L V Q APM G + + V AG KV G L V+ AMKME + SP +GT
Sbjct: 1102 PKALKDVKGQIG-----APMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGT 1156
Query: 694 VKKV 697
V+KV
Sbjct: 1157 VRKV 1160
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (967), Expect = e-104
Identities = 214/540 (39%), Positives = 308/540 (57%), Gaps = 9/540 (1%)
Query: 49 ITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQ-QSY 107
I KV++ANRGEIA RV R +LG++TVA+YSE D MH ADEAY IG + Q+Y
Sbjct: 37 IKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAY 96
Query: 108 LSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSK 167
L + II+VAK + A+HPG GFLSE +FA+ C+ G+ FIGP P +R MG K ++
Sbjct: 97 LHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEAR 156
Query: 168 SIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQ 227
+I AAGVPVV G S E + G+P++ KA GGGG+GMR+V S +E +E
Sbjct: 157 AIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEEN 216
Query: 228 LESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIE 287
A EA +F + A+ +EKF++ PRH+EVQ+ GD +GN ++L+ERDCS+QRRHQK++E
Sbjct: 217 YTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVE 276
Query: 288 EAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVT 347
APA + ++R +L +V+ AK V Y AGTVEF++D F+E+N+RLQVEH VT
Sbjct: 277 IAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVT 336
Query: 348 EMITGTDLVEWQLRIAAGEKIP---LSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVH 404
E IT DLV Q+ +A G +P L QE I + G A + R+ EDP+ +F P G +
Sbjct: 337 EEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEV 396
Query: 405 LSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLH 464
+ QG +S HYD ++ K++ D A TK+ +L ++ + G+
Sbjct: 397 FRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVK 456
Query: 465 TNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTD 524
TNI FL N+ + +F AG V T FI + + +L R A + LG ++ T
Sbjct: 457 TNIAFLQNVLNNQQFLAGTVDTQFIDE-NPELFQLRPAQNRAQKLLHYLGHVMVNGPTTP 515
Query: 525 TFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQ 584
+ P + + R++ L++G A AV NH G + + D TF+
Sbjct: 516 IPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVR-NHPG---LLLMDTTFR 571
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/64 (45%), Positives = 35/64 (54%), Gaps = 5/64 (7%)
Query: 634 PKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGT 693
PK L V Q APM G + + V AG KV G L V+ AMKME + SP +GT
Sbjct: 1102 PKALKDVKGQIG-----APMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGT 1156
Query: 694 VKKV 697
V+KV
Sbjct: 1157 VRKV 1160
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (967), Expect = e-104
Identities = 214/540 (39%), Positives = 308/540 (57%), Gaps = 9/540 (1%)
Query: 49 ITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQ-QSY 107
I KV++ANRGEIA RV R +LG++TVA+YSE D MH ADEAY IG + Q+Y
Sbjct: 37 IKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAY 96
Query: 108 LSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSK 167
L + II+VAK + A+HPG GFLSE +FA+ C+ G+ FIGP P +R MG K ++
Sbjct: 97 LHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEAR 156
Query: 168 SIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQ 227
+I AAGVPVV G S E + G+P++ KA GGGG+GMR+V S +E +E
Sbjct: 157 AIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEEN 216
Query: 228 LESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIE 287
A EA +F + A+ +EKF++ PRH+EVQ+ GD +GN ++L+ERDCS+QRRHQK++E
Sbjct: 217 YTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVE 276
Query: 288 EAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVT 347
APA + ++R +L +V+ AK V Y AGTVEF++D F+E+N+RLQVEH VT
Sbjct: 277 IAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVT 336
Query: 348 EMITGTDLVEWQLRIAAGEKIP---LSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVH 404
E IT DLV Q+ +A G +P L QE I + G A + R+ EDP+ +F P G +
Sbjct: 337 EEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEV 396
Query: 405 LSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLH 464
+ QG +S HYD ++ K++ D A TK+ +L ++ + G+
Sbjct: 397 FRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVK 456
Query: 465 TNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTD 524
TNI FL N+ + +F AG V T FI + + +L R A + LG ++ T
Sbjct: 457 TNIAFLQNVLNNQQFLAGTVDTQFIDE-NPELFQLRPAQNRAQKLLHYLGHVMVNGPTTP 515
Query: 525 TFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQ 584
+ P + + R++ L++G A AV NH G + + D TF+
Sbjct: 516 IPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVR-NHPG---LLLMDTTFR 571
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/64 (45%), Positives = 35/64 (54%), Gaps = 5/64 (7%)
Query: 634 PKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGT 693
PK L V Q APM G + + V AG KV G L V+ AMKME + SP +GT
Sbjct: 1102 PKALKDVKGQIG-----APMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGT 1156
Query: 694 VKKV 697
V+KV
Sbjct: 1157 VRKV 1160
>gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 236 bits (602), Expect = 6e-62
Identities = 210/759 (27%), Positives = 332/759 (43%), Gaps = 117/759 (15%)
Query: 40 KYTTATGRN--ITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNS 86
++ T G N I KVLIAN G A + MR+ ++ ++ V + + D N+
Sbjct: 107 EFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 166
Query: 87 MHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEG 146
++ MAD + P+ +Y ++E I+ +AK QA+ G G SEN + EL + G
Sbjct: 167 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 226
Query: 147 IIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE--------GYHGEDQSDQCLK------ 192
I F+GPP A+ +G K S + AG+P + + D S + L
Sbjct: 227 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 286
Query: 193 ------------EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
+ A +GYPVMIKA GGGGKG+R V + +F + E S
Sbjct: 287 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS-- 344
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
+ + + RH+EVQ+ D +GNA+ LF RDCSVQRRHQKIIEEAPA V +
Sbjct: 345 --PIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 402
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
+ + AV+ AK V YV AGTVE++ +F F+E+N RLQVEHP TEM+ +L QL
Sbjct: 403 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 462
Query: 361 RIAAGEKIPLSQ-EEITL-----------------------QGHAFEARIYAEDPSNNFM 396
+IA G IPL + ++I + +GH ARI +E+P F
Sbjct: 463 QIAMG--IPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFK 520
Query: 397 PVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLR 456
P +G + L+ R++ + V + D W +R+ A++ + +L+
Sbjct: 521 PSSGTVQELNF-RSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 579
Query: 457 QYNIVG-LHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL 515
+ +I G T +++L+ L F+ + T ++ + L++ K A+ LG+
Sbjct: 580 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDR-----LIAEKVQAERP--DTMLGV 632
Query: 516 ILKEKAMTDTFTLQAHDQFSPFSSSSGRRL---NISYTRNMTLKDGKNNVAIAVTYNHDG 572
+ + D + F S G+ L + T ++ L + VT
Sbjct: 633 VCGALHVADVSLRNSVSNFL-HSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPN 691
Query: 573 SYSMQIEDKTFQVLGNLYSEGD----------CTYLKCSVNGVASKAKLIILENTIYLFS 622
SY + + +V + S+G TY+K V+ I + N +F
Sbjct: 692 SYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYR-----ITIGNKTCVFE 746
Query: 623 KEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM 682
KE P + S P G + + V+ G V AG + MKM
Sbjct: 747 KEND-------PSVMRS------------PSAGKLIQYIVEDGGHVFAGQCYAEIEVMKM 787
Query: 683 EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDK 721
T+ + + G + V R GA + L + + + K
Sbjct: 788 VMTLTAVESGCIHYV-KRPGAALDPGCVLAKMQLDNPSK 825
>gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo
sapiens]
Length = 2268
Score = 236 bits (602), Expect = 6e-62
Identities = 210/759 (27%), Positives = 332/759 (43%), Gaps = 117/759 (15%)
Query: 40 KYTTATGRN--ITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNS 86
++ T G N I KVLIAN G A + MR+ ++ ++ V + + D N+
Sbjct: 29 EFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 88
Query: 87 MHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEG 146
++ MAD + P+ +Y ++E I+ +AK QA+ G G SEN + EL + G
Sbjct: 89 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 148
Query: 147 IIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE--------GYHGEDQSDQCLK------ 192
I F+GPP A+ +G K S + AG+P + + D S + L
Sbjct: 149 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 208
Query: 193 ------------EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
+ A +GYPVMIKA GGGGKG+R V + +F + E S
Sbjct: 209 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS-- 266
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
+ + + RH+EVQ+ D +GNA+ LF RDCSVQRRHQKIIEEAPA V +
Sbjct: 267 --PIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 324
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
+ + AV+ AK V YV AGTVE++ +F F+E+N RLQVEHP TEM+ +L QL
Sbjct: 325 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 384
Query: 361 RIAAGEKIPLSQ-EEITL-----------------------QGHAFEARIYAEDPSNNFM 396
+IA G IPL + ++I + +GH ARI +E+P F
Sbjct: 385 QIAMG--IPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFK 442
Query: 397 PVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLR 456
P +G + L+ R++ + V + D W +R+ A++ + +L+
Sbjct: 443 PSSGTVQELNF-RSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 501
Query: 457 QYNIVG-LHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL 515
+ +I G T +++L+ L F+ + T ++ + L++ K A+ LG+
Sbjct: 502 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDR-----LIAEKVQAERP--DTMLGV 554
Query: 516 ILKEKAMTDTFTLQAHDQFSPFSSSSGRRL---NISYTRNMTLKDGKNNVAIAVTYNHDG 572
+ + D + F S G+ L + T ++ L + VT
Sbjct: 555 VCGALHVADVSLRNSVSNFL-HSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPN 613
Query: 573 SYSMQIEDKTFQVLGNLYSEGD----------CTYLKCSVNGVASKAKLIILENTIYLFS 622
SY + + +V + S+G TY+K V+ I + N +F
Sbjct: 614 SYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYR-----ITIGNKTCVFE 668
Query: 623 KEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM 682
KE P + S P G + + V+ G V AG + MKM
Sbjct: 669 KEND-------PSVMRS------------PSAGKLIQYIVEDGGHVFAGQCYAEIEVMKM 709
Query: 683 EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDK 721
T+ + + G + V R GA + L + + + K
Sbjct: 710 VMTLTAVESGCIHYV-KRPGAALDPGCVLAKMQLDNPSK 747
>gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo
sapiens]
Length = 2288
Score = 236 bits (602), Expect = 6e-62
Identities = 210/759 (27%), Positives = 332/759 (43%), Gaps = 117/759 (15%)
Query: 40 KYTTATGRN--ITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNS 86
++ T G N I KVLIAN G A + MR+ ++ ++ V + + D N+
Sbjct: 49 EFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 108
Query: 87 MHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEG 146
++ MAD + P+ +Y ++E I+ +AK QA+ G G SEN + EL + G
Sbjct: 109 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 168
Query: 147 IIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE--------GYHGEDQSDQCLK------ 192
I F+GPP A+ +G K S + AG+P + + D S + L
Sbjct: 169 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 228
Query: 193 ------------EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
+ A +GYPVMIKA GGGGKG+R V + +F + E S
Sbjct: 229 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS-- 286
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
+ + + RH+EVQ+ D +GNA+ LF RDCSVQRRHQKIIEEAPA V +
Sbjct: 287 --PIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 344
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
+ + AV+ AK V YV AGTVE++ +F F+E+N RLQVEHP TEM+ +L QL
Sbjct: 345 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 404
Query: 361 RIAAGEKIPLSQ-EEITL-----------------------QGHAFEARIYAEDPSNNFM 396
+IA G IPL + ++I + +GH ARI +E+P F
Sbjct: 405 QIAMG--IPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFK 462
Query: 397 PVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLR 456
P +G + L+ R++ + V + D W +R+ A++ + +L+
Sbjct: 463 PSSGTVQELNF-RSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 521
Query: 457 QYNIVG-LHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL 515
+ +I G T +++L+ L F+ + T ++ + L++ K A+ LG+
Sbjct: 522 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDR-----LIAEKVQAERP--DTMLGV 574
Query: 516 ILKEKAMTDTFTLQAHDQFSPFSSSSGRRL---NISYTRNMTLKDGKNNVAIAVTYNHDG 572
+ + D + F S G+ L + T ++ L + VT
Sbjct: 575 VCGALHVADVSLRNSVSNFL-HSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPN 633
Query: 573 SYSMQIEDKTFQVLGNLYSEGD----------CTYLKCSVNGVASKAKLIILENTIYLFS 622
SY + + +V + S+G TY+K V+ I + N +F
Sbjct: 634 SYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYR-----ITIGNKTCVFE 688
Query: 623 KEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM 682
KE P + S P G + + V+ G V AG + MKM
Sbjct: 689 KEND-------PSVMRS------------PSAGKLIQYIVEDGGHVFAGQCYAEIEVMKM 729
Query: 683 EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDK 721
T+ + + G + V R GA + L + + + K
Sbjct: 730 VMTLTAVESGCIHYV-KRPGAALDPGCVLAKMQLDNPSK 767
>gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 236 bits (602), Expect = 6e-62
Identities = 210/759 (27%), Positives = 332/759 (43%), Gaps = 117/759 (15%)
Query: 40 KYTTATGRN--ITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNS 86
++ T G N I KVLIAN G A + MR+ ++ ++ V + + D N+
Sbjct: 107 EFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 166
Query: 87 MHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEG 146
++ MAD + P+ +Y ++E I+ +AK QA+ G G SEN + EL + G
Sbjct: 167 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 226
Query: 147 IIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE--------GYHGEDQSDQCLK------ 192
I F+GPP A+ +G K S + AG+P + + D S + L
Sbjct: 227 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 286
Query: 193 ------------EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
+ A +GYPVMIKA GGGGKG+R V + +F + E S
Sbjct: 287 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS-- 344
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
+ + + RH+EVQ+ D +GNA+ LF RDCSVQRRHQKIIEEAPA V +
Sbjct: 345 --PIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 402
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
+ + AV+ AK V YV AGTVE++ +F F+E+N RLQVEHP TEM+ +L QL
Sbjct: 403 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 462
Query: 361 RIAAGEKIPLSQ-EEITL-----------------------QGHAFEARIYAEDPSNNFM 396
+IA G IPL + ++I + +GH ARI +E+P F
Sbjct: 463 QIAMG--IPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFK 520
Query: 397 PVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLR 456
P +G + L+ R++ + V + D W +R+ A++ + +L+
Sbjct: 521 PSSGTVQELNF-RSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 579
Query: 457 QYNIVG-LHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL 515
+ +I G T +++L+ L F+ + T ++ + L++ K A+ LG+
Sbjct: 580 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDR-----LIAEKVQAERP--DTMLGV 632
Query: 516 ILKEKAMTDTFTLQAHDQFSPFSSSSGRRL---NISYTRNMTLKDGKNNVAIAVTYNHDG 572
+ + D + F S G+ L + T ++ L + VT
Sbjct: 633 VCGALHVADVSLRNSVSNFL-HSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPN 691
Query: 573 SYSMQIEDKTFQVLGNLYSEGD----------CTYLKCSVNGVASKAKLIILENTIYLFS 622
SY + + +V + S+G TY+K V+ I + N +F
Sbjct: 692 SYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYR-----ITIGNKTCVFE 746
Query: 623 KEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM 682
KE P + S P G + + V+ G V AG + MKM
Sbjct: 747 KEND-------PSVMRS------------PSAGKLIQYIVEDGGHVFAGQCYAEIEVMKM 787
Query: 683 EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDK 721
T+ + + G + V R GA + L + + + K
Sbjct: 788 VMTLTAVESGCIHYV-KRPGAALDPGCVLAKMQLDNPSK 825
>gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo
sapiens]
Length = 2383
Score = 236 bits (602), Expect = 6e-62
Identities = 210/759 (27%), Positives = 332/759 (43%), Gaps = 117/759 (15%)
Query: 40 KYTTATGRN--ITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNS 86
++ T G N I KVLIAN G A + MR+ ++ ++ V + + D N+
Sbjct: 144 EFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 203
Query: 87 MHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEG 146
++ MAD + P+ +Y ++E I+ +AK QA+ G G SEN + EL + G
Sbjct: 204 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 263
Query: 147 IIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE--------GYHGEDQSDQCLK------ 192
I F+GPP A+ +G K S + AG+P + + D S + L
Sbjct: 264 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 323
Query: 193 ------------EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFN 240
+ A +GYPVMIKA GGGGKG+R V + +F + E S
Sbjct: 324 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS-- 381
Query: 241 DDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRK 300
+ + + RH+EVQ+ D +GNA+ LF RDCSVQRRHQKIIEEAPA V +
Sbjct: 382 --PIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 439
Query: 301 KLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQL 360
+ + AV+ AK V YV AGTVE++ +F F+E+N RLQVEHP TEM+ +L QL
Sbjct: 440 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 499
Query: 361 RIAAGEKIPLSQ-EEITL-----------------------QGHAFEARIYAEDPSNNFM 396
+IA G IPL + ++I + +GH ARI +E+P F
Sbjct: 500 QIAMG--IPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFK 557
Query: 397 PVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLR 456
P +G + L+ R++ + V + D W +R+ A++ + +L+
Sbjct: 558 PSSGTVQELNF-RSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 616
Query: 457 QYNIVG-LHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL 515
+ +I G T +++L+ L F+ + T ++ + L++ K A+ LG+
Sbjct: 617 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDR-----LIAEKVQAERP--DTMLGV 669
Query: 516 ILKEKAMTDTFTLQAHDQFSPFSSSSGRRL---NISYTRNMTLKDGKNNVAIAVTYNHDG 572
+ + D + F S G+ L + T ++ L + VT
Sbjct: 670 VCGALHVADVSLRNSVSNFL-HSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPN 728
Query: 573 SYSMQIEDKTFQVLGNLYSEGD----------CTYLKCSVNGVASKAKLIILENTIYLFS 622
SY + + +V + S+G TY+K V+ I + N +F
Sbjct: 729 SYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYR-----ITIGNKTCVFE 783
Query: 623 KEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM 682
KE P + S P G + + V+ G V AG + MKM
Sbjct: 784 KEND-------PSVMRS------------PSAGKLIQYIVEDGGHVFAGQCYAEIEVMKM 824
Query: 683 EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDK 721
T+ + + G + V R GA + L + + + K
Sbjct: 825 VMTLTAVESGCIHYV-KRPGAALDPGCVLAKMQLDNPSK 862
>gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens]
Length = 2458
Score = 235 bits (600), Expect = 9e-62
Identities = 211/749 (28%), Positives = 325/749 (43%), Gaps = 112/749 (14%)
Query: 47 RNITKVLIANRGEIACRVMRTAKKLG---------VQTVAVYSEAD--RNSMHVDMADEA 95
R I KVLIAN G A + MR+ ++ ++ V + + D N+ ++ MAD
Sbjct: 258 RVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 317
Query: 96 YSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPS 155
+ P+ +Y ++E I+ +AK QA+ G G SEN + EL + G+ F+GPP
Sbjct: 318 VPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSE 377
Query: 156 AIRDMGIKSTSKSIMAAAGVPVVEGYHG--------------------EDQSDQ-CLK-- 192
A+ +G K S + VP + ED D+ C+K
Sbjct: 378 AMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDV 437
Query: 193 ----EHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK 248
E A RIG+P+MIKA GGGGKG+R S ++F + E S + + K
Sbjct: 438 DEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGS----PIFLMK 493
Query: 249 FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVR 308
RH+EVQ+ D +GNAV LF RDCS+QRRHQKI+EEAPA + + + + A+R
Sbjct: 494 LAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIR 553
Query: 309 AAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKI 368
AK V YV AGTVE++ +F F+E+N RLQVEHP TEMI +L QL+IA G +
Sbjct: 554 LAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL 613
Query: 369 ------------------PLSQEEIT----LQGHAFEARIYAEDPSNNFMPVAGPLVHLS 406
P+S E + +GH ARI +E+P F P +G + L+
Sbjct: 614 HRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELN 673
Query: 407 TPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVG-LHT 465
R+ + V + D W +R+ A++ + +L++ +I G T
Sbjct: 674 F-RSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRT 732
Query: 466 NIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGL--ILKEKAMT 523
+++L+NL F+ ++ T ++ + + + K + AL + + MT
Sbjct: 733 TVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMT 792
Query: 524 DTFTLQAHDQFSPFSSSSGRRLNISYTR------NMTLKDGKNNVAIAVTYNHD-----G 572
D Q P S LN+ LK + ++ + V +
Sbjct: 793 DFLHSLERGQVLPADS----LLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEID 848
Query: 573 SYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIP 632
++ + GN Y+ TY+K V+ I + N +F KE
Sbjct: 849 AHRLNDGGLLLSYNGNSYT----TYMKEEVDSYR-----ITIGNKTCVFEKEND------ 893
Query: 633 VPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDG 692
P L S P G + + V+ G V+AG S M MKM T+ + G
Sbjct: 894 -PTVLRS------------PSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERG 940
Query: 693 TVKKVFYREGAQANRHTPLVEFEEEESDK 721
VK + R GA + E ++ K
Sbjct: 941 RVKYI-KRPGAVLEAGCVVARLELDDPSK 968
>gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo
sapiens]
Length = 1049
Score = 62.4 bits (150), Expect = 1e-09
Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 27/310 (8%)
Query: 65 MRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQA 124
+RT ++LG +TV V + S D D+ Y LS+E+I+ + A
Sbjct: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
Query: 125 IHPGCGFLSENMEFAELCKQEGIIFIGPPPSAI---RDMGIKSTSKSIMAAAGVPVVEGY 181
G N L K G+ +G P I D I S + A P +
Sbjct: 601 CIISVGGQIPNNLAVPLYK-NGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP----W 655
Query: 182 HGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFND 241
+ ++ L E A+ + YP +++ G M +V SE E ++ LE A R ++ +
Sbjct: 656 KAVNTLNEAL-EFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQ----E 710
Query: 242 DAMLIEKFVDTPRHVEVQVFGDHH---GNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEV 298
+++ KFV+ R VE+ G +A+ D V ++ P I
Sbjct: 711 HPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLM--LPTQTISQGA 768
Query: 299 RKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEW 358
+K+ +A + AKA G V+F++ ++ +E N R P G D ++
Sbjct: 769 IEKVKDATRKIAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVDFIDV 827
Query: 359 QLRIAAGEKI 368
++ GE +
Sbjct: 828 ATKVMIGENV 837
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 9/178 (5%)
Query: 195 ARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPR 254
A IGYPVMI++ GG G I + + + K + +L+EK V +
Sbjct: 126 ADTIGYPVMIRSAYALGGLGSGICPNRETLMD------LSTKAFAMTNQILVEKSVTGWK 179
Query: 255 HVEVQVFGDHHGNAVYL--FERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKA 312
+E +V D N V + E ++ + APA + + + L ++ +
Sbjct: 180 EIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRH 239
Query: 313 VNYVGAGTVEFIM-DSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
+ VG ++F + + +C +E+N RL + TG L +IA G +P
Sbjct: 240 LGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLP 297
>gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precursor
[Homo sapiens]
Length = 1506
Score = 62.4 bits (150), Expect = 1e-09
Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 27/310 (8%)
Query: 65 MRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQA 124
+RT ++LG +TV V + S D D+ Y LS+E+I+ + A
Sbjct: 1006 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1057
Query: 125 IHPGCGFLSENMEFAELCKQEGIIFIGPPPSAI---RDMGIKSTSKSIMAAAGVPVVEGY 181
G N L K G+ +G P I D I S + A P +
Sbjct: 1058 CIISVGGQIPNNLAVPLYK-NGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP----W 1112
Query: 182 HGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFND 241
+ ++ L E A+ + YP +++ G M +V SE E ++ LE A R ++ +
Sbjct: 1113 KAVNTLNEAL-EFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQ----E 1167
Query: 242 DAMLIEKFVDTPRHVEVQVFGDHH---GNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEV 298
+++ KFV+ R VE+ G +A+ D V ++ P I
Sbjct: 1168 HPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLM--LPTQTISQGA 1225
Query: 299 RKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEW 358
+K+ +A + AKA G V+F++ ++ +E N R P G D ++
Sbjct: 1226 IEKVKDATRKIAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVDFIDV 1284
Query: 359 QLRIAAGEKI 368
++ GE +
Sbjct: 1285 ATKVMIGENV 1294
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 9/178 (5%)
Query: 195 ARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPR 254
A IGYPVMI++ GG G I + + + K + +L+EK V +
Sbjct: 583 ADTIGYPVMIRSAYALGGLGSGICPNRETLMD------LSTKAFAMTNQILVEKSVTGWK 636
Query: 255 HVEVQVFGDHHGNAVYL--FERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKA 312
+E +V D N V + E ++ + APA + + + L ++ +
Sbjct: 637 EIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRH 696
Query: 313 VNYVGAGTVEFIM-DSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
+ VG ++F + + +C +E+N RL + TG L +IA G +P
Sbjct: 697 LGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLP 754
>gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor
[Homo sapiens]
Length = 1500
Score = 62.4 bits (150), Expect = 1e-09
Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 27/310 (8%)
Query: 65 MRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQA 124
+RT ++LG +TV V + S D D+ Y LS+E+I+ + A
Sbjct: 1000 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1051
Query: 125 IHPGCGFLSENMEFAELCKQEGIIFIGPPPSAI---RDMGIKSTSKSIMAAAGVPVVEGY 181
G N L K G+ +G P I D I S + A P +
Sbjct: 1052 CIISVGGQIPNNLAVPLYK-NGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP----W 1106
Query: 182 HGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFND 241
+ ++ L E A+ + YP +++ G M +V SE E ++ LE A R ++ +
Sbjct: 1107 KAVNTLNEAL-EFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQ----E 1161
Query: 242 DAMLIEKFVDTPRHVEVQVFGDHH---GNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEV 298
+++ KFV+ R VE+ G +A+ D V ++ P I
Sbjct: 1162 HPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLM--LPTQTISQGA 1219
Query: 299 RKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEW 358
+K+ +A + AKA G V+F++ ++ +E N R P G D ++
Sbjct: 1220 IEKVKDATRKIAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVDFIDV 1278
Query: 359 QLRIAAGEKI 368
++ GE +
Sbjct: 1279 ATKVMIGENV 1288
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 9/178 (5%)
Query: 195 ARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPR 254
A IGYPVMI++ GG G I + + + K + +L+EK V +
Sbjct: 577 ADTIGYPVMIRSAYALGGLGSGICPNRETLMD------LSTKAFAMTNQILVEKSVTGWK 630
Query: 255 HVEVQVFGDHHGNAVYL--FERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKA 312
+E +V D N V + E ++ + APA + + + L ++ +
Sbjct: 631 EIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRH 690
Query: 313 VNYVGAGTVEFIM-DSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
+ VG ++F + + +C +E+N RL + TG L +IA G +P
Sbjct: 691 LGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLP 748
>gi|18105007 carbamoylphosphate synthetase 2/aspartate
transcarbamylase/dihydroorotase [Homo sapiens]
Length = 2225
Score = 55.1 bits (131), Expect = 2e-07
Identities = 65/335 (19%), Positives = 134/335 (40%), Gaps = 30/335 (8%)
Query: 63 RVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAA 122
+ ++ K+ +QT+ + +AD+ Y + P + ++I+ +
Sbjct: 418 QAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHY-----VTQVIRNERPDGV 472
Query: 123 QAIHPGCGFLSENMEF--AELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVV-- 178
G L+ +E A + + G+ +G P I + + MA G V
Sbjct: 473 LLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPS 532
Query: 179 EGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKS 238
E + +Q+ A R+GYPV+++A GG G + +E + A +
Sbjct: 533 EAANSLEQAQAA----AERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQ- 587
Query: 239 FNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR------RHQKIIEEAPAP 292
+L++K + + +E +V D +GN V + C+++ + I AP+
Sbjct: 588 -----VLVDKSLKGWKEIEYEVVRDAYGNCVTV----CNMENLDPLGIHTGESIVVAPSQ 638
Query: 293 GIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMD-SKHNFCFMEMNTRLQVEHPVTEMIT 351
+ + L + A++ + + VG V++ ++ + +E+N RL + T
Sbjct: 639 TLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKAT 698
Query: 352 GTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARI 386
G L ++A G +P + +T AFE +
Sbjct: 699 GYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSV 733
Score = 42.7 bits (99), Expect = 0.001
Identities = 53/301 (17%), Positives = 112/301 (37%), Gaps = 17/301 (5%)
Query: 69 KKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPG 128
+K+G +T+ V + S DM D Y +S E ++ + + + +
Sbjct: 963 RKMGYKTIMVNYNPETVSTDYDMCDRLYF--------DEISFEVVMDIYELENPEGVILS 1014
Query: 129 CGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSD 188
G N L +Q+ + +G P AI + ++ G+ + D
Sbjct: 1015 MGGQLPNNMAMALHRQQCRV-LGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDL-- 1071
Query: 189 QCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK 248
+ ++ + +GYP +++ G M + ++ + + L SA +K + ++I K
Sbjct: 1072 ESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSK----EHPVVISK 1127
Query: 249 FVDTPRHVEVQ-VFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAV 307
F+ + ++V V D A+ + E + P I ++ +++
Sbjct: 1128 FIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVH 1187
Query: 308 RAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEK 367
+ + G ++ I +E N R+ P G DLV R+ GE+
Sbjct: 1188 AVGQELQVTGPFNLQLIAKDDQ-LKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEE 1246
Query: 368 I 368
+
Sbjct: 1247 V 1247
>gi|110671329 dihydrolipoamide branched chain transacylase precursor
[Homo sapiens]
Length = 482
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/70 (34%), Positives = 36/70 (51%)
Query: 656 TIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFE 715
T+++ +VK GD V DS+ + + K TI S DG +KK++Y A PLV+ E
Sbjct: 80 TVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIE 139
Query: 716 EEESDKRESE 725
E E +
Sbjct: 140 TEALKDSEED 149
>gi|164663810 ribosomal modification protein rimK-like family member
A [Homo sapiens]
Length = 391
Score = 35.8 bits (81), Expect = 0.14
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 170 MAAAGVPVVE--GYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQ 227
+A GVP+ + Y G + + + E A +GYPV++K+ RG GK + + R + +
Sbjct: 118 LAGHGVPMPDTFSYGGHEDFSKMIDE-AEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDI 176
Query: 228 LESARREAKKSFNDDAMLIEKFVDTPRHVEVQV 260
R +D L +K+V +++V
Sbjct: 177 CHLIR-------HDVPYLFQKYVKESHGKDIRV 202
>gi|134254462 ribosomal modification protein rimK-like family member
B [Homo sapiens]
Length = 386
Score = 34.7 bits (78), Expect = 0.32
Identities = 43/190 (22%), Positives = 79/190 (41%), Gaps = 16/190 (8%)
Query: 154 PSAIRDMGIKSTSKSIMAAAGVPVVEGY-HGEDQSDQCLKEHARRIGYPVMIKAVRGGGG 212
P AI + K + +A GVP+ + + +G ++ + + A + +P+++K RG G
Sbjct: 106 PQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRG 165
Query: 213 KGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTP--RHVEVQVFGDHHGNAVY 270
K + + R + + R EA L +K+V R V V V G G V
Sbjct: 166 KAVFLARDKHHLADLSHLIRHEA-------PYLFQKYVKESHGRDVRVIVVG---GRVVG 215
Query: 271 LFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHN 330
R CS R Q G+ + ++ + A++ + + G ++ +M +
Sbjct: 216 TMLR-CSTDGRMQSNC-SLGGVGMMCSLSEQGKQLAIQVSNILGMDVCG-IDLLMKDDGS 272
Query: 331 FCFMEMNTRL 340
FC E N +
Sbjct: 273 FCVCEANANV 282
>gi|203098816 pyruvate dehydrogenase complex, component X isoform 2
[Homo sapiens]
Length = 486
Score = 33.9 bits (76), Expect = 0.55
Identities = 21/66 (31%), Positives = 32/66 (48%)
Query: 655 GTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEF 714
G I K K G+ V AGD+L + K T+ + DG + K+ EG++ R L+
Sbjct: 56 GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGL 115
Query: 715 EEEESD 720
EE +
Sbjct: 116 IVEEGE 121
>gi|203098753 pyruvate dehydrogenase complex, component X isoform 1
[Homo sapiens]
Length = 501
Score = 33.9 bits (76), Expect = 0.55
Identities = 21/66 (31%), Positives = 32/66 (48%)
Query: 655 GTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEF 714
G I K K G+ V AGD+L + K T+ + DG + K+ EG++ R L+
Sbjct: 71 GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGL 130
Query: 715 EEEESD 720
EE +
Sbjct: 131 IVEEGE 136
>gi|28416899 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 2 [Homo
sapiens]
Length = 433
Score = 33.1 bits (74), Expect = 0.93
Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 117 AKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVP 176
A T+ ++ I +S++ A+ CK++ I F+ P A GI +S P
Sbjct: 37 AGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGP 96
Query: 177 VVEGYHGEDQSDQCLKEHARRIGYP------------------------VMIKAVRGGGG 212
E E S + KE R G P +++KA G
Sbjct: 97 TAEAAQLES-SKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAG 155
Query: 213 KGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVD 251
KG+ + +S++E + ++ +E + ++IE+ +D
Sbjct: 156 KGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLD 194
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 33.1 bits (74), Expect = 0.93
Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 117 AKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVP 176
A T+ ++ I +S++ A+ CK++ I F+ P A GI +S P
Sbjct: 37 AGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGP 96
Query: 177 VVEGYHGEDQSDQCLKEHARRIGYP------------------------VMIKAVRGGGG 212
E E S + KE R G P +++KA G
Sbjct: 97 TAEAAQLES-SKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAG 155
Query: 213 KGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVD 251
KG+ + +S++E + ++ +E + ++IE+ +D
Sbjct: 156 KGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLD 194
>gi|209869995 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 33.1 bits (74), Expect = 0.93
Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 117 AKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVP 176
A T+ ++ I +S++ A+ CK++ I F+ P A GI +S P
Sbjct: 37 AGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGP 96
Query: 177 VVEGYHGEDQSDQCLKEHARRIGYP------------------------VMIKAVRGGGG 212
E E S + KE R G P +++KA G
Sbjct: 97 TAEAAQLES-SKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAG 155
Query: 213 KGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVD 251
KG+ + +S++E + ++ +E + ++IE+ +D
Sbjct: 156 KGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLD 194
>gi|209869993 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 33.1 bits (74), Expect = 0.93
Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 117 AKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVP 176
A T+ ++ I +S++ A+ CK++ I F+ P A GI +S P
Sbjct: 37 AGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGP 96
Query: 177 VVEGYHGEDQSDQCLKEHARRIGYP------------------------VMIKAVRGGGG 212
E E S + KE R G P +++KA G
Sbjct: 97 TAEAAQLES-SKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAG 155
Query: 213 KGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVD 251
KG+ + +S++E + ++ +E + ++IE+ +D
Sbjct: 156 KGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLD 194
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 552 NMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKL 611
N+ +K KN+ + T S SMQ E KT + S D + ++ G++S+AKL
Sbjct: 11956 NIRVKWFKNDQRLHTTR----SVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 12011
Query: 612 IILENTIYLFSK 623
+LE Y K
Sbjct: 12012 TVLEGDPYFTGK 12023
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 552 NMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKL 611
N+ +K KN+ + T S SMQ E KT + S D + ++ G++S+AKL
Sbjct: 5651 NIRVKWFKNDQRLHTTR----SVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5706
Query: 612 IILENTIYLFSK 623
+LE Y K
Sbjct: 5707 TVLEGDPYFTGK 5718
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 552 NMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKL 611
N+ +K KN+ + T S SMQ E KT + S D + ++ G++S+AKL
Sbjct: 5584 NIRVKWFKNDQRLHTTR----SVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5639
Query: 612 IILENTIYLFSK 623
+LE Y K
Sbjct: 5640 TVLEGDPYFTGK 5651
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 552 NMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKL 611
N+ +K KN+ + T S SMQ E KT + S D + ++ G++S+AKL
Sbjct: 5459 NIRVKWFKNDQRLHTTR----SVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5514
Query: 612 IILENTIYLFSK 623
+LE Y K
Sbjct: 5515 TVLEGDPYFTGK 5526
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 31.2 bits (69), Expect = 3.5
Identities = 18/91 (19%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 218 VRSEQEFQEQLESARREAKKSFNDDAM--LIEKFVDTP-----RHVEVQVFGDHHGNAVY 270
V E+ F+E+ + ++E++KSF ++ + L E+ + P + + ++
Sbjct: 718 VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 777
Query: 271 LFERDCSVQRRHQKIIEEAPAPGIKSEVRKK 301
L E++ ++++ + I E P +S++++K
Sbjct: 778 LVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 808
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,519,359
Number of Sequences: 37866
Number of extensions: 1129113
Number of successful extensions: 2877
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2771
Number of HSP's gapped (non-prelim): 68
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.